## Fri Nov 15 13:34:02 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/bin_4635/bin/bin17/MMS_3_bin.19.fa -m mmseqs --itype genome -o MMS_3_bin.19 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/4635/MMS_3_bin.19 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
MMS3_k127_1005825_5	1079986.JH164846_gene1937	6.876e-21	105.0	2C1EG@1|root,2Z7MZ@2|Bacteria,2GK4W@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_1005825_6	1380370.JIBA01000012_gene3905	4.646e-16	92.0	COG4409@1|root,COG4409@2|Bacteria,2IDDY@201174|Actinobacteria,4FH84@85021|Intrasporangiaceae	201174|Actinobacteria	G	exo-alpha-(2->6)-sialidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_1005825_8	42256.RradSPS_2946	1.622e-08	67.0	COG0589@1|root,COG0589@2|Bacteria,2GSJK@201174|Actinobacteria,4CQXK@84995|Rubrobacteria	84995|Rubrobacteria	T	COG COG0589 Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms	-	-	-	-	-	-	-	-	-	-	-	-	Usp
MMS3_k127_1005825_7	1131730.BAVI_13324	2.902e-11	73.0	COG0842@1|root,COG0842@2|Bacteria,1TT5K@1239|Firmicutes,4HGJI@91061|Bacilli,1ZF2I@1386|Bacillus	91061|Bacilli	V	ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
MMS3_k127_1005825_4	1536769.P40081_13815	4.518e-26	122.0	COG0842@1|root,COG0842@2|Bacteria,1V0J8@1239|Firmicutes,4HEBH@91061|Bacilli,26U1I@186822|Paenibacillaceae	91061|Bacilli	V	ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
MMS3_k127_1005825_2	1121946.AUAX01000031_gene985	3.206e-92	313.0	COG1131@1|root,COG1131@2|Bacteria,2GTNE@201174|Actinobacteria,4DAIB@85008|Micromonosporales	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
MMS3_k127_1005825_1	448385.sce1571	6.364e-102	344.0	COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,42NW8@68525|delta/epsilon subdivisions,2WJY1@28221|Deltaproteobacteria,2YV62@29|Myxococcales	28221|Deltaproteobacteria	C	Dehydrogenase E1 component	bkdA	-	1.2.4.1,1.2.4.4	ko:K00161,ko:K00166	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
MMS3_k127_1005825_0	290397.Adeh_1826	4.565e-127	434.0	COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,42N06@68525|delta/epsilon subdivisions,2WK5N@28221|Deltaproteobacteria,2YTX4@29|Myxococcales	28221|Deltaproteobacteria	C	Transketolase, pyrimidine binding domain	bkdB	-	1.2.4.1,1.2.4.4	ko:K00162,ko:K00167	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
MMS3_k127_1005825_3	1242864.D187_009911	2.637e-32	131.0	COG0508@1|root,COG0508@2|Bacteria,1MU7K@1224|Proteobacteria,42MYB@68525|delta/epsilon subdivisions,2WIUY@28221|Deltaproteobacteria,2YU5E@29|Myxococcales	28221|Deltaproteobacteria	C	acetyltransferase component of pyruvate dehydrogenase complex	pdhC	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
MMS3_k127_1017018_4	224325.AF_1728	1.556e-24	114.0	COG0438@1|root,arCOG01403@2157|Archaea,2XVAJ@28890|Euryarchaeota,245P8@183980|Archaeoglobi	183980|Archaeoglobi	M	Glycosyltransferase Family 4	-	-	2.4.1.87	ko:K00743	ko00601,map00601	-	R05978,R06169	-	ko00000,ko00001,ko01000,ko01003	-	GT6	-	Glyco_transf_4,Glycos_transf_1
MMS3_k127_1017018_0	1234679.BN424_2278	2.039e-113	379.0	COG0214@1|root,COG0214@2|Bacteria,1TPSZ@1239|Firmicutes,4H9RA@91061|Bacilli,27FKQ@186828|Carnobacteriaceae	91061|Bacilli	H	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively	pdxS	GO:0003674,GO:0005488,GO:0005515,GO:0042802	4.3.3.6	ko:K06215	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SOR_SNZ
MMS3_k127_1017018_2	186497.PF1518	2.598e-37	155.0	COG4143@1|root,arCOG00226@2157|Archaea,2XT44@28890|Euryarchaeota,24311@183968|Thermococci	183968|Thermococci	H	ABC-type thiamine transport system, periplasmic component	-	-	-	ko:K02064	ko02010,map02010	M00191	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.19	-	-	SBP_bac_6,SBP_bac_8
MMS3_k127_1017018_3	1043205.AFYF01000051_gene3025	3.571e-33	149.0	COG1178@1|root,COG1178@2|Bacteria,2GKDH@201174|Actinobacteria,4FHPR@85021|Intrasporangiaceae	201174|Actinobacteria	P	Binding-protein-dependent transport system inner membrane component	thiP	-	-	ko:K02011,ko:K02063	ko02010,map02010	M00190,M00191	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10,3.A.1.19	-	-	BPD_transp_1
MMS3_k127_1017018_1	926569.ANT_23590	2.983e-64	231.0	COG3842@1|root,COG3842@2|Bacteria,2G62Z@200795|Chloroflexi	200795|Chloroflexi	P	TOBE domain	-	-	3.6.3.31	ko:K02062,ko:K11072	ko02010,map02010	M00191,M00299	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.11.1,3.A.1.19	-	-	ABC_tran,TOBE_2
MMS3_k127_1018315_0	273116.14325124	1.383e-57	221.0	COG2244@1|root,arCOG02209@2157|Archaea,2Y7AT@28890|Euryarchaeota,24273@183967|Thermoplasmata	183967|Thermoplasmata	S	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt_3,Polysacc_synt_C
MMS3_k127_1018427_9	1054217.TALC_01281	2.542e-12	77.0	COG1938@1|root,arCOG00347@2157|Archaea,2XT93@28890|Euryarchaeota,242F5@183967|Thermoplasmata	183967|Thermoplasmata	S	PAC2 family	-	-	-	ko:K06869	-	-	-	-	ko00000	-	-	-	PAC2
MMS3_k127_1018427_3	1121472.AQWN01000008_gene1917	2.796e-101	339.0	COG0247@1|root,COG0247@2|Bacteria,1TPG1@1239|Firmicutes,24B1K@186801|Clostridia,260UJ@186807|Peptococcaceae	186801|Clostridia	C	Fe-S oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	CCG
MMS3_k127_1018427_6	767817.Desgi_0795	4.013e-33	135.0	COG1150@1|root,COG1150@2|Bacteria,1W0FB@1239|Firmicutes,252WX@186801|Clostridia	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03390	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_17
MMS3_k127_1018427_1	1121422.AUMW01000009_gene3349	3.572e-210	685.0	COG1148@1|root,COG1148@2|Bacteria,1V5YJ@1239|Firmicutes,248CC@186801|Clostridia,260ZH@186807|Peptococcaceae	186801|Clostridia	C	binding domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Pyr_redox_2
MMS3_k127_1018427_0	1121422.AUMW01000009_gene3350	9.269e-317	993.0	COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,26166@186807|Peptococcaceae	186801|Clostridia	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_20,Pyr_redox_2
MMS3_k127_1018427_5	1121472.AQWN01000008_gene1912	2.635e-43	170.0	COG1908@1|root,COG1908@2|Bacteria,1V80C@1239|Firmicutes,24MB7@186801|Clostridia,264Z4@186807|Peptococcaceae	186801|Clostridia	C	Methyl-viologen-reducing hydrogenase, delta subunit	-	-	1.8.98.5,1.8.98.6	ko:K14127	ko00680,map00680	-	R00019,R11943,R11944	RC00011	ko00000,ko00001,ko01000	-	-	-	FlpD
MMS3_k127_1018427_8	747365.Thena_0467	1.662e-27	127.0	COG0425@1|root,COG0425@2|Bacteria,1VJRT@1239|Firmicutes,24V06@186801|Clostridia	186801|Clostridia	O	Sulfurtransferase TusA	-	-	-	-	-	-	-	-	-	-	-	-	TusA
MMS3_k127_1018427_4	693746.OBV_01210	1.716e-51	190.0	COG0425@1|root,COG0446@1|root,COG0607@1|root,COG2210@1|root,COG0425@2|Bacteria,COG0446@2|Bacteria,COG0607@2|Bacteria,COG2210@2|Bacteria,1TPWW@1239|Firmicutes,2484C@186801|Clostridia,2N6UE@216572|Oscillospiraceae	186801|Clostridia	P	Rhodanese Homology Domain	cdr	-	-	-	-	-	-	-	-	-	-	-	DrsE_2,Pyr_redox_2,Pyr_redox_dim,Rhodanese,TusA
MMS3_k127_1018427_15	586413.CCDL010000004_gene3416	0.0003659	50.0	COG2318@1|root,COG2318@2|Bacteria,1V6ZG@1239|Firmicutes,4HJ60@91061|Bacilli,23KRT@182709|Oceanobacillus	91061|Bacilli	S	DinB family	yizA	-	-	-	-	-	-	-	-	-	-	-	DinB
MMS3_k127_1018427_7	196162.Noca_4384	1.959e-31	125.0	COG2114@1|root,COG2114@2|Bacteria,2IQEQ@201174|Actinobacteria,4DV53@85009|Propionibacteriales	201174|Actinobacteria	T	Protein of unknown function (DUF4242)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4242
MMS3_k127_1018427_14	240015.ACP_2213	0.0001073	54.0	COG0793@1|root,COG0793@2|Bacteria,3Y8YS@57723|Acidobacteria,2JNXX@204432|Acidobacteriia	204432|Acidobacteriia	M	Belongs to the peptidase S41A family	-	-	-	-	-	-	-	-	-	-	-	-	Asp_protease_2
MMS3_k127_1018427_12	1206732.BAGD01000104_gene4601	2.636e-07	62.0	COG5516@1|root,COG5516@2|Bacteria,2I9ZA@201174|Actinobacteria,4G1M2@85025|Nocardiaceae	201174|Actinobacteria	S	Putative stress-induced transcription regulator	-	-	-	-	-	-	-	-	-	-	-	-	ABATE,zf-CGNR
MMS3_k127_1018427_11	288000.BBta_p0056	1.718e-08	57.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2TR80@28211|Alphaproteobacteria,3JQNW@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hydrolase,YHS
MMS3_k127_1018427_2	1187851.A33M_4031	1.186e-143	482.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2TR80@28211|Alphaproteobacteria,3FCW2@34008|Rhodovulum	28211|Alphaproteobacteria	P	haloacid dehalogenase-like hydrolase	MA20_24480	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hydrolase,YHS
MMS3_k127_1018427_13	68219.JNXI01000001_gene5902	7.086e-07	54.0	COG0500@1|root,COG0500@2|Bacteria,2GX4K@201174|Actinobacteria	201174|Actinobacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
MMS3_k127_1022519_4	1236689.MMALV_02330	6.525e-44	168.0	COG1985@1|root,arCOG01484@2157|Archaea,2XU47@28890|Euryarchaeota,3F2MK@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	RibD C-terminal domain	ribG	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006139,GO:0006725,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009451,GO:0009987,GO:0016070,GO:0016491,GO:0016614,GO:0016616,GO:0017144,GO:0018130,GO:0034641,GO:0036094,GO:0042364,GO:0042726,GO:0042727,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0046983,GO:0048037,GO:0050661,GO:0050662,GO:0051287,GO:0055114,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	1.1.1.302	ko:K14654	ko00740,ko01100,map00740,map01100	-	R09375,R09376	RC00933	ko00000,ko00001,ko01000	-	-	-	RibD_C
MMS3_k127_1022519_2	273057.SSO2773	6.31e-53	208.0	COG0179@1|root,arCOG00235@2157|Archaea,2XQQH@28889|Crenarchaeota	28889|Crenarchaeota	Q	PFAM fumarylacetoacetate (FAA) hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
MMS3_k127_1022519_1	351160.LRC299	2.994e-59	221.0	COG1467@1|root,arCOG04110@2157|Archaea,2XUZF@28890|Euryarchaeota,2N95F@224756|Methanomicrobia	224756|Methanomicrobia	L	Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair	priS	-	-	ko:K02683	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_primase_S
MMS3_k127_1022519_5	70601.3257995	3.155e-38	160.0	COG1094@1|root,arCOG04150@2157|Archaea,2XUHX@28890|Euryarchaeota,24319@183968|Thermococci	183968|Thermococci	J	Pfam:KH_3	-	-	-	ko:K06961	-	-	-	-	ko00000,ko03009	-	-	-	KH_1
MMS3_k127_1022519_3	351160.LRC287	4.725e-45	174.0	COG1718@1|root,arCOG01180@2157|Archaea,2XU2H@28890|Euryarchaeota,2N9ET@224756|Methanomicrobia	224756|Methanomicrobia	T	serine threonine protein kinase	-	-	2.7.11.1	ko:K07178	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko01001,ko03009	-	-	-	RIO1
MMS3_k127_1022519_7	273075.Ta0728	1.971e-29	125.0	arCOG07179@1|root,arCOG07179@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_1022519_8	673860.AciM339_0539	8.789e-21	98.0	COG1585@1|root,arCOG01912@2157|Archaea,2Y07X@28890|Euryarchaeota,3F2T3@33867|unclassified Euryarchaeota	28890|Euryarchaeota	O	NfeD-like C-terminal, partner-binding	-	-	-	-	-	-	-	-	-	-	-	-	NfeD
MMS3_k127_1022519_0	304371.MCP_1835	5.64e-122	404.0	COG0330@1|root,arCOG01915@2157|Archaea,2XTA2@28890|Euryarchaeota,2N9RK@224756|Methanomicrobia	224756|Methanomicrobia	O	PFAM band 7 protein	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
MMS3_k127_1022519_6	985053.VMUT_0977	6.031e-36	151.0	COG0438@1|root,arCOG01419@2157|Archaea,2XRYK@28889|Crenarchaeota	28889|Crenarchaeota	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
MMS3_k127_1048646_0	1042877.GQS_01315	5.673e-127	415.0	COG1372@1|root,COG1690@1|root,arCOG03158@2157|Archaea,arCOG04246@2157|Archaea,2XTIC@28890|Euryarchaeota,24310@183968|Thermococci	183968|Thermococci	J	tRNA-splicing ligase that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs	rtcB	GO:0000166,GO:0000394,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003972,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008380,GO:0008452,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016886,GO:0017076,GO:0019001,GO:0019002,GO:0030145,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901363	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Intein_splicing,LAGLIDADG_3,RtcB
MMS3_k127_1048646_3	1047013.AQSP01000122_gene2223	1.427e-21	112.0	COG3291@1|root,COG3291@2|Bacteria,2NQ6Y@2323|unclassified Bacteria	2|Bacteria	M	PKD domain	-	-	3.2.1.91	ko:K19668	ko00500,ko01100,ko02020,map00500,map01100,map02020	-	R02886,R11308	RC00799	ko00000,ko00001,ko01000	-	GH6	-	CBM_2,CHU_C,FlgD_ig,Glyco_hydro_6,PKD,VCBS
MMS3_k127_1048646_4	323259.Mhun_0426	1.222e-06	63.0	COG3291@1|root,arCOG03606@1|root,arCOG02510@2157|Archaea,arCOG03606@2157|Archaea,2Y7RP@28890|Euryarchaeota,2NBKZ@224756|Methanomicrobia	224756|Methanomicrobia	S	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	PKD
MMS3_k127_1048646_2	263820.PTO0187	1.827e-46	194.0	COG4934@1|root,arCOG03665@2157|Archaea,2Y1PU@28890|Euryarchaeota,241Z3@183967|Thermoplasmata	183967|Thermoplasmata	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
MMS3_k127_1048646_1	673860.AciM339_0749	3.009e-60	226.0	COG0517@1|root,COG0750@1|root,arCOG00607@2157|Archaea,arCOG04064@2157|Archaea,2XSZP@28890|Euryarchaeota,3F2KK@33867|unclassified Euryarchaeota	28890|Euryarchaeota	M	Peptidase family M50	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Peptidase_M50
MMS3_k127_1048646_5	410358.Mlab_1252	1.043e-05	59.0	COG2219@1|root,arCOG03013@2157|Archaea,2XTDT@28890|Euryarchaeota,2N9HY@224756|Methanomicrobia	224756|Methanomicrobia	L	Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair	priL	-	-	ko:K18882	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_primase_lrg
MMS3_k127_1052239_2	565033.GACE_1085	4.109e-26	112.0	COG3255@1|root,arCOG01842@2157|Archaea,2XXJM@28890|Euryarchaeota,2468P@183980|Archaeoglobi	183980|Archaeoglobi	I	SCP-2 sterol transfer family	-	-	-	-	-	-	-	-	-	-	-	-	SCP2
MMS3_k127_1052239_4	335659.S23_14310	5.299e-05	55.0	COG0412@1|root,COG0412@2|Bacteria,1MW7S@1224|Proteobacteria,2TTPH@28211|Alphaproteobacteria,3JTSR@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Dienelactone hydrolase family	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
MMS3_k127_1052239_5	1236689.MMALV_01120	7.461e-05	51.0	COG1412@1|root,arCOG04312@2157|Archaea,2Y0D4@28890|Euryarchaeota,3F2SM@33867|unclassified Euryarchaeota	28890|Euryarchaeota	V	Fcf1	-	-	-	ko:K07158	-	-	-	-	ko00000	-	-	-	PIN
MMS3_k127_1052239_1	1499967.BAYZ01000098_gene4388	3.101e-110	376.0	COG0318@1|root,COG0318@2|Bacteria,2NPH9@2323|unclassified Bacteria	2|Bacteria	IQ	COGs COG0318 Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
MMS3_k127_1052239_3	1206731.BAGB01000054_gene3673	3.985e-14	79.0	COG0406@1|root,COG0494@1|root,COG0406@2|Bacteria,COG0494@2|Bacteria,2GNRV@201174|Actinobacteria,4FVR6@85025|Nocardiaceae	201174|Actinobacteria	GL	Belongs to the Nudix hydrolase family	mutT	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	His_Phos_1,NUDIX
MMS3_k127_1052239_0	273075.Ta0239m	5.157e-205	647.0	COG2987@1|root,arCOG04670@2157|Archaea,2XT9Q@28890|Euryarchaeota,24215@183967|Thermoplasmata	183967|Thermoplasmata	E	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate	hutU	-	4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000	-	-	-	Urocanase,Urocanase_C,Urocanase_N
MMS3_k127_1054708_0	913865.DOT_5765	2.939e-13	82.0	COG4658@1|root,COG4658@2|Bacteria,1V4CY@1239|Firmicutes	1239|Firmicutes	C	Belongs to the NqrB RnfD family	-	-	-	-	-	-	-	-	-	-	-	-	NQR2_RnfD_RnfE
MMS3_k127_1066674_3	1056495.Calag_0964	1.219e-19	106.0	COG0747@1|root,arCOG01533@2157|Archaea	2157|Archaea	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	PKD,SBP_bac_5
MMS3_k127_1066674_1	399549.Msed_1207	9.147e-45	176.0	arCOG06267@1|root,arCOG06267@2157|Archaea	2157|Archaea	V	antibiotic catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_1066674_0	273057.SSO0992	3.65e-51	197.0	COG0477@1|root,arCOG00130@2157|Archaea,2XRP4@28889|Crenarchaeota	28889|Crenarchaeota	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS3_k127_1066674_4	1236689.MMALV_16070	5.009e-14	83.0	arCOG10616@1|root,arCOG10616@2157|Archaea,2Y2PB@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_1066674_2	1236689.MMALV_16080	1.127e-25	123.0	arCOG03776@1|root,arCOG03776@2157|Archaea,2Y2C3@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_1131462_28	523791.Kkor_1812	7.113e-12	79.0	COG3291@1|root,COG4412@1|root,COG3291@2|Bacteria,COG4412@2|Bacteria,1PFDE@1224|Proteobacteria,1RWU9@1236|Gammaproteobacteria,1XNU8@135619|Oceanospirillales	135619|Oceanospirillales	M	PKD domain	-	-	3.2.1.91	ko:K09607,ko:K19668	ko00500,ko01100,ko02020,map00500,map01100,map02020	-	R02886,R11308	RC00799	ko00000,ko00001,ko01000,ko01002	-	GH6	-	PKD
MMS3_k127_1131462_27	588932.JHOF01000023_gene1920	1.03e-12	82.0	COG3391@1|root,COG3391@2|Bacteria,1P862@1224|Proteobacteria,2V9VC@28211|Alphaproteobacteria,2KJJ6@204458|Caulobacterales	204458|Caulobacterales	S	TIGRFAM 40-residue YVTN family beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
MMS3_k127_1131462_21	321327.CYA_1203	4.851e-23	108.0	COG1011@1|root,COG1011@2|Bacteria,1G51I@1117|Cyanobacteria,1H0H2@1129|Synechococcus	1117|Cyanobacteria	S	Haloacid dehalogenase-like hydrolase	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2,Hydrolase
MMS3_k127_1131462_3	1121440.AUMA01000009_gene653	6.154e-80	278.0	COG0702@1|root,COG0702@2|Bacteria,1PDTN@1224|Proteobacteria,42M8X@68525|delta/epsilon subdivisions,2WJ5J@28221|Deltaproteobacteria,2M7RB@213115|Desulfovibrionales	28221|Deltaproteobacteria	GM	NAD-dependent epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	DUF2867,NAD_binding_10
MMS3_k127_1131462_26	1380370.JIBA01000012_gene3412	1.657e-14	88.0	COG4101@1|root,COG4101@2|Bacteria,2II42@201174|Actinobacteria,4FGN5@85021|Intrasporangiaceae	201174|Actinobacteria	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
MMS3_k127_1131462_14	273075.Ta1085	7.45e-47	184.0	COG0477@1|root,arCOG00132@2157|Archaea,2Y6B6@28890|Euryarchaeota,241YZ@183967|Thermoplasmata	183967|Thermoplasmata	G	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
MMS3_k127_1131462_30	1121945.ATXS01000009_gene1708	2.365e-08	59.0	COG1599@1|root,arCOG01510@2157|Archaea,2XTJP@28890|Euryarchaeota,23U8X@183963|Halobacteria	183963|Halobacteria	L	COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins	rpa2	-	-	ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko03000,ko03032,ko03400	-	-	-	REPA_OB_2,tRNA_anti-codon
MMS3_k127_1131462_19	273075.Ta1097	8.863e-30	126.0	COG3374@1|root,arCOG04349@2157|Archaea	2157|Archaea	S	Protein of unknown function (DUF981)	-	-	-	ko:K08980	-	-	-	-	ko00000	-	-	-	DUF981
MMS3_k127_1131462_2	945713.IALB_2363	1.234e-82	282.0	COG0656@1|root,COG0656@2|Bacteria	2|Bacteria	S	aldo-keto reductase (NADP) activity	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
MMS3_k127_1131462_23	1041930.Mtc_2092	3.308e-20	105.0	COG3368@1|root,arCOG02444@2157|Archaea	2157|Archaea	S	Membrane protein of 12 TMs	-	-	-	ko:K01992,ko:K07087	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	12TM_1
MMS3_k127_1131462_6	1041930.Mtc_2093	3.48e-76	271.0	COG1131@1|root,arCOG00194@2157|Archaea,2XT7Q@28890|Euryarchaeota	28890|Euryarchaeota	E	ABC-type multidrug transport system, ATPase component	trp2	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
MMS3_k127_1131462_31	3641.EOY26344	0.0001031	56.0	KOG0379@1|root,KOG0379@2759|Eukaryota,37SDU@33090|Viridiplantae,3G8Y8@35493|Streptophyta	35493|Streptophyta	S	F-box kelch-repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	F-box,F-box-like,Kelch_3,Kelch_4,Kelch_5
MMS3_k127_1131462_18	1047013.AQSP01000122_gene2224	2.045e-30	140.0	COG3291@1|root,COG5434@1|root,COG3291@2|Bacteria,COG5434@2|Bacteria,2NQ6Y@2323|unclassified Bacteria	2|Bacteria	M	PKD domain	-	-	3.2.1.157,3.2.1.91	ko:K19668,ko:K20850	ko00500,ko01100,ko02020,map00500,map01100,map02020	-	R02886,R11308	RC00799	ko00000,ko00001,ko01000	-	GH6,GH82	-	Beta_helix,CHU_C,Cadherin-like,FlgD_ig,PKD,Pectate_lyase_3
MMS3_k127_1131462_7	266117.Rxyl_2864	1.881e-73	255.0	COG0225@1|root,COG0225@2|Bacteria,2GJ1S@201174|Actinobacteria,4CQJ5@84995|Rubrobacteria	84995|Rubrobacteria	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
MMS3_k127_1131462_16	1379698.RBG1_1C00001G1376	6.748e-35	140.0	COG5424@1|root,COG5424@2|Bacteria	2|Bacteria	H	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ	CP_1111	GO:0005575,GO:0005576	1.3.3.11	ko:K06137	-	-	-	-	ko00000,ko01000	-	-	-	Haem_oxygenas_2,TENA_THI-4
MMS3_k127_1131462_22	266117.Rxyl_2932	1.759e-20	98.0	COG2062@1|root,COG2062@2|Bacteria	2|Bacteria	T	phosphohistidine phosphatase, SixA	sixA	-	-	ko:K08296	-	-	-	-	ko00000,ko01000	-	-	-	His_Phos_1
MMS3_k127_1131462_9	632292.Calhy_2414	2.31e-68	240.0	COG0125@1|root,COG0125@2|Bacteria,1V0EA@1239|Firmicutes,24AIX@186801|Clostridia,42I1F@68295|Thermoanaerobacterales	186801|Clostridia	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	-	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
MMS3_k127_1131462_8	1459636.NTE_00051	5.942e-71	252.0	COG0125@1|root,arCOG01891@2157|Archaea	2157|Archaea	F	thymidylate kinase	-	GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
MMS3_k127_1131462_4	670487.Ocepr_1830	1.226e-77	282.0	COG0248@1|root,COG0248@2|Bacteria,1WIS5@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	FP	Exopolyphosphatase	-	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	HD,Ppx-GppA
MMS3_k127_1131462_17	1449126.JQKL01000036_gene1934	1.144e-33	141.0	COG0704@1|root,COG0704@2|Bacteria,1URN3@1239|Firmicutes,24FTM@186801|Clostridia,268P9@186813|unclassified Clostridiales	186801|Clostridia	P	Plays a role in the regulation of phosphate uptake	phoU	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
MMS3_k127_1131462_5	1280954.HPO_12688	4.966e-77	279.0	COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,2TQX9@28211|Alphaproteobacteria,43WF1@69657|Hyphomonadaceae	28211|Alphaproteobacteria	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
MMS3_k127_1131462_13	1382304.JNIL01000001_gene3013	4.892e-52	197.0	COG0581@1|root,COG0581@2|Bacteria,1TP74@1239|Firmicutes,4HAKF@91061|Bacilli,279AY@186823|Alicyclobacillaceae	91061|Bacilli	P	TIGRFAM phosphate ABC transporter, inner membrane subunit PstA	pstA	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
MMS3_k127_1131462_15	266117.Rxyl_0819	8.402e-39	158.0	COG0573@1|root,COG0573@2|Bacteria,2GJDA@201174|Actinobacteria,4CPSR@84995|Rubrobacteria	84995|Rubrobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
MMS3_k127_1131462_11	419947.MRA_0942	2.537e-60	234.0	COG0226@1|root,COG0226@2|Bacteria,2IDU5@201174|Actinobacteria,23CM7@1762|Mycobacteriaceae	201174|Actinobacteria	P	Part of the ABC transporter complex PstSACB involved in phosphate import	pstS1	GO:0003674,GO:0005488,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0015698,GO:0016020,GO:0016036,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042301,GO:0042594,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0071496,GO:0071944	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
MMS3_k127_1131462_25	679926.Mpet_1253	3.032e-16	91.0	COG0704@1|root,arCOG00318@2157|Archaea,2XUA4@28890|Euryarchaeota,2N9P3@224756|Methanomicrobia	224756|Methanomicrobia	K	Phosphate uptake regulator, PhoU	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin,PhoU
MMS3_k127_1131462_1	1259795.ARJK01000003_gene1170	4.75e-105	359.0	COG0477@1|root,COG2814@2|Bacteria,1TPRN@1239|Firmicutes,249RZ@186801|Clostridia,42F2C@68295|Thermoanaerobacterales	186801|Clostridia	P	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
MMS3_k127_1131462_20	263820.PTO0540	9.404e-24	106.0	COG0517@1|root,arCOG00606@2157|Archaea,2Y0BC@28890|Euryarchaeota,242A4@183967|Thermoplasmata	183967|Thermoplasmata	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
MMS3_k127_1131462_29	1121351.AUAP01000001_gene574	5.217e-09	64.0	COG1403@1|root,COG1403@2|Bacteria,1PUQ3@1224|Proteobacteria,2VU38@28216|Betaproteobacteria,2KRNU@206351|Neisseriales	206351|Neisseriales	L	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH
MMS3_k127_1131462_12	1459636.NTE_02968	7.092e-59	222.0	COG1055@1|root,arCOG00238@2157|Archaea	2157|Archaea	P	Citrate transporter	arsB	-	-	-	-	-	-	-	-	-	-	-	CitMHS
MMS3_k127_1131462_24	1056495.Calag_0145	6.397e-20	106.0	COG0436@1|root,arCOG04334@2157|Archaea,2XSCB@28889|Crenarchaeota	28889|Crenarchaeota	E	PFAM Aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
MMS3_k127_1131462_0	273075.Ta0068	8.883e-132	440.0	COG0160@1|root,arCOG00915@2157|Archaea,2Y83J@28890|Euryarchaeota,2421R@183967|Thermoplasmata	183967|Thermoplasmata	E	Aminotransferase class-III	-	-	2.6.1.19	ko:K00823	ko00250,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
MMS3_k127_1131462_10	1459636.NTE_02181	1.019e-64	241.0	COG1063@1|root,arCOG01459@2157|Archaea,41S98@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Glucose dehydrogenase C-terminus	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
MMS3_k127_1131462_32	156978.CIMIT_02785	0.0002378	45.0	COG1208@1|root,COG1208@2|Bacteria,2GKTE@201174|Actinobacteria,22KFH@1653|Corynebacteriaceae	201174|Actinobacteria	JM	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B gamma epsilon subunits	manC	-	2.7.7.13	ko:K00966	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
MMS3_k127_1141119_3	1094980.Mpsy_2342	0.0007624	50.0	COG0467@1|root,arCOG01178@2157|Archaea,2Y0GM@28890|Euryarchaeota	28890|Euryarchaeota	T	PFAM GvpD gas vesicle	gvpD	-	-	-	-	-	-	-	-	-	-	-	GvpD
MMS3_k127_1141119_1	263820.PTO0117	1.42e-79	287.0	arCOG03664@1|root,arCOG03664@2157|Archaea,2Y0U7@28890|Euryarchaeota,242CQ@183967|Thermoplasmata	183967|Thermoplasmata	G	Glycosyl transferase family group 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_2_3
MMS3_k127_1141119_0	266117.Rxyl_0618	1.834e-303	962.0	COG1048@1|root,COG1048@2|Bacteria,2GJD5@201174|Actinobacteria,4CPJQ@84995|Rubrobacteria	84995|Rubrobacteria	C	Aconitase C-terminal domain	-	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
MMS3_k127_1141119_2	247490.KSU1_C0970	5.798e-65	242.0	COG0863@1|root,COG0863@2|Bacteria,2J4GH@203682|Planctomycetes	203682|Planctomycetes	L	Belongs to the N(4) N(6)-methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_1179473_1	1236689.MMALV_10170	7.915e-18	85.0	COG0112@1|root,arCOG00070@2157|Archaea,2XU0H@28890|Euryarchaeota,3F2G1@33867|unclassified Euryarchaeota	28890|Euryarchaeota	E	Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
MMS3_k127_1179473_3	340.xcc-b100_4421	2.119e-06	62.0	COG4625@1|root,COG4625@2|Bacteria,1QU2X@1224|Proteobacteria,1SG73@1236|Gammaproteobacteria,1X5NU@135614|Xanthomonadales	135614|Xanthomonadales	M	Autotransporter beta-domain	-	-	-	-	-	-	-	-	-	-	-	-	Autotransporter,Calx-beta,He_PIG
MMS3_k127_1179473_0	1120973.AQXL01000134_gene1691	1.509e-22	115.0	COG0122@1|root,COG0122@2|Bacteria,1TQAF@1239|Firmicutes,4HBYM@91061|Bacilli,278IH@186823|Alicyclobacillaceae	91061|Bacilli	L	endonuclease III	-	-	3.2.2.21	ko:K01247	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
MMS3_k127_1179473_2	1307759.JOMJ01000003_gene1460	2.014e-11	68.0	COG1514@1|root,COG1514@2|Bacteria,1RDB2@1224|Proteobacteria,42TMM@68525|delta/epsilon subdivisions,2WQ6S@28221|Deltaproteobacteria,2MCME@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	-	-	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
MMS3_k127_1198356_2	673860.AciM339_0319	1.127e-49	181.0	COG0054@1|root,arCOG01323@2157|Archaea,2XXXC@28890|Euryarchaeota,3F2P5@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
MMS3_k127_1198356_3	935866.JAER01000001_gene2692	4.079e-25	115.0	COG0340@1|root,COG0340@2|Bacteria,2GN8Q@201174|Actinobacteria,4DQT5@85009|Propionibacteriales	201174|Actinobacteria	H	Biotin/lipoate A/B protein ligase family	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB
MMS3_k127_1198356_0	357808.RoseRS_3291	2.058e-202	643.0	COG4799@1|root,COG4799@2|Bacteria,2G5IX@200795|Chloroflexi,3750V@32061|Chloroflexia	32061|Chloroflexia	I	PFAM carboxyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Carboxyl_trans
MMS3_k127_1198356_1	273068.TTE1336	2.69e-147	505.0	COG5016@1|root,COG5016@2|Bacteria,1VT8P@1239|Firmicutes,247NZ@186801|Clostridia,42EY5@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM Conserved carboxylase region	pycB	-	4.1.1.3,6.4.1.1	ko:K01571,ko:K01960	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173,M00620	R00217,R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000,ko02000	3.B.1.1.1	-	-	Biotin_lipoyl,HMGL-like,PYC_OADA
MMS3_k127_1205198_1	1056495.Calag_1003	4.354e-55	223.0	COG3391@1|root,arCOG06052@1|root,arCOG02560@2157|Archaea,arCOG06052@2157|Archaea,2XRYP@28889|Crenarchaeota	28889|Crenarchaeota	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_1205198_4	1254432.SCE1572_16320	1.179e-31	137.0	COG0640@1|root,COG0640@2|Bacteria,1N3ZI@1224|Proteobacteria	1224|Proteobacteria	K	TRANSCRIPTIONal	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
MMS3_k127_1205198_2	1254432.SCE1572_16325	9.223e-52	196.0	COG3832@1|root,COG3832@2|Bacteria,1RDTP@1224|Proteobacteria	1224|Proteobacteria	S	activator of Hsp90 ATPase 1 family protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
MMS3_k127_1205198_5	994573.T472_0213900	1.38e-20	100.0	COG0454@1|root,COG0456@2|Bacteria,1V562@1239|Firmicutes,24G6G@186801|Clostridia,36HZD@31979|Clostridiaceae	186801|Clostridia	K	Acetyltransferase (GNAT) domain	-	GO:0003674,GO:0003824,GO:0016740,GO:0016746,GO:0016747	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
MMS3_k127_1205198_7	273075.Ta1236	1.03e-09	71.0	arCOG07408@1|root,arCOG07408@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_1205198_3	713586.KB900536_gene3012	7.115e-44	166.0	COG0346@1|root,COG0346@2|Bacteria,1N116@1224|Proteobacteria,1S4X5@1236|Gammaproteobacteria,1X14C@135613|Chromatiales	135613|Chromatiales	E	Glyoxalase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
MMS3_k127_1205198_6	1121898.Q766_05980	8.395e-14	86.0	COG3209@1|root,COG3209@2|Bacteria,4PKBQ@976|Bacteroidetes,1IJ6N@117743|Flavobacteriia,2NSCF@237|Flavobacterium	976|Bacteroidetes	M	SprB repeat	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,Laminin_G_3,SprB
MMS3_k127_1205198_8	1348663.KCH_42750	0.0001312	55.0	COG0367@1|root,COG0367@2|Bacteria,2GMIY@201174|Actinobacteria,2M2JS@2063|Kitasatospora	201174|Actinobacteria	E	Asparagine synthase	-	-	-	-	-	-	-	-	-	-	-	-	Asn_synthase
MMS3_k127_1205198_0	28042.GU90_06605	1.949e-59	216.0	COG1960@1|root,COG1960@2|Bacteria,2I8DF@201174|Actinobacteria,4E0UR@85010|Pseudonocardiales	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	ko:K04117	ko00362,ko01120,map00362,map01120	M00540	R05619	RC02035	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
MMS3_k127_1217752_3	439481.Aboo_0185	9.769e-84	286.0	COG0638@1|root,arCOG00971@2157|Archaea,2XUKA@28890|Euryarchaeota,3F2G0@33867|unclassified Euryarchaeota	28890|Euryarchaeota	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	psmA	GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0019538,GO:0019773,GO:0030163,GO:0032991,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03432	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome,Proteasome_A_N
MMS3_k127_1217752_5	673860.AciM339_0866	2.836e-68	248.0	COG1500@1|root,arCOG04187@2157|Archaea,2XTNH@28890|Euryarchaeota,3F2JN@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Shwachman-Bodian-Diamond syndrome (SBDS) protein	-	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363	-	ko:K14574	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	SBDS,SBDS_C
MMS3_k127_1217752_7	439481.Aboo_0183	5.232e-57	209.0	COG1097@1|root,arCOG00678@2157|Archaea,2XWEN@28890|Euryarchaeota,3F2JY@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome	rrp4	GO:0000178,GO:0000288,GO:0000291,GO:0000459,GO:0000460,GO:0000466,GO:0000467,GO:0000469,GO:0000956,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006364,GO:0006396,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016072,GO:0016073,GO:0016074,GO:0016180,GO:0019222,GO:0019439,GO:0022613,GO:0031123,GO:0031125,GO:0031126,GO:0032991,GO:0034470,GO:0034472,GO:0034475,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0042254,GO:0043144,GO:0043170,GO:0043628,GO:0043928,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071034,GO:0071043,GO:0071051,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1902494,GO:1905354	-	ko:K03679	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	ECR1_N,KH_1,KH_6,S1
MMS3_k127_1217752_2	391623.TERMP_00163	1.1e-88	299.0	COG0689@1|root,arCOG01575@2157|Archaea,2XVHI@28890|Euryarchaeota,242PZ@183968|Thermococci	183968|Thermococci	J	Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'- 5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails	rrp41	GO:0000177,GO:0000178,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575,GO:1902494,GO:1905354	-	ko:K11600	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	RNase_PH,RNase_PH_C
MMS3_k127_1217752_4	342949.PNA2_0135	3.436e-74	267.0	COG2123@1|root,arCOG01574@2157|Archaea,2XWTK@28890|Euryarchaeota,2433E@183968|Thermococci	183968|Thermococci	J	Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site	rrp42	GO:0000177,GO:0000178,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0017091,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1902494,GO:1905354	-	ko:K12589	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	RNase_PH,RNase_PH_C
MMS3_k127_1217752_12	604354.TSIB_1345	8.718e-12	71.0	COG1997@1|root,arCOG04208@2157|Archaea,2XYWD@28890|Euryarchaeota,244K8@183968|Thermococci	183968|Thermococci	J	binds to the 23S rRNA	rpl37ae	-	-	ko:K02921	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L37ae
MMS3_k127_1217752_13	1054217.TALC_00324	4.152e-09	58.0	COG1996@1|root,arCOG04341@2157|Archaea,2Y5VN@28890|Euryarchaeota	28890|Euryarchaeota	K	DNA directed RNA polymerase, 7 kDa subunit	-	-	2.7.7.6	ko:K03059	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	DNA_RNApol_7kD
MMS3_k127_1217752_9	368407.Memar_2159	5.631e-46	174.0	COG0468@1|root,arCOG00417@2157|Archaea,2XTI2@28890|Euryarchaeota,2N9KC@224756|Methanomicrobia	224756|Methanomicrobia	L	Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange	radB	-	-	ko:K04484	-	-	-	-	ko00000,ko03400	-	-	-	Rad51
MMS3_k127_1217752_10	1304275.C41B8_17828	1.471e-34	139.0	COG0350@1|root,COG0350@2|Bacteria,1N2YQ@1224|Proteobacteria,1S68H@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated	ogt	GO:0003674,GO:0003824,GO:0003908,GO:0006139,GO:0006259,GO:0006281,GO:0006304,GO:0006307,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0009987,GO:0016740,GO:0016741,GO:0032259,GO:0033554,GO:0034641,GO:0035510,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1,Methyltransf_1N
MMS3_k127_1217752_0	439481.Aboo_0072	1.636e-302	948.0	COG0480@1|root,arCOG01559@2157|Archaea,2XUMQ@28890|Euryarchaeota,3F2GN@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K03234	ko04152,ko04921,map04152,map04921	-	-	-	ko00000,ko00001,ko03012,ko04147	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
MMS3_k127_1217752_8	1236689.MMALV_03250	3.601e-54	198.0	COG0049@1|root,arCOG04254@2157|Archaea,2XTDC@28890|Euryarchaeota,3F2JI@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center	rps7	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
MMS3_k127_1217752_6	439481.Aboo_0070	4.314e-68	235.0	COG0048@1|root,arCOG04255@2157|Archaea,2XX4A@28890|Euryarchaeota,3F2K0@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits	rps12	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
MMS3_k127_1217752_11	1254432.SCE1572_44135	1.069e-31	133.0	COG1573@1|root,COG1573@2|Bacteria,1MWX1@1224|Proteobacteria,42QXV@68525|delta/epsilon subdivisions,2WS71@28221|Deltaproteobacteria,2Z31Q@29|Myxococcales	28221|Deltaproteobacteria	L	Uracil DNA glycosylase superfamily	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
MMS3_k127_1217752_1	673860.AciM339_1269	3.077e-226	735.0	COG0417@1|root,arCOG00328@2157|Archaea,2XU1K@28890|Euryarchaeota,3F2F0@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	DNA polymerase type-B family	polB1	-	2.7.7.7	ko:K02319	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_pol_B,DNA_pol_B_exo1,Intein_splicing
MMS3_k127_1254327_9	742738.HMPREF9460_03626	3.962e-21	96.0	COG1884@1|root,COG1884@2|Bacteria,1TQAD@1239|Firmicutes,24BDK@186801|Clostridia,268AK@186813|unclassified Clostridiales	186801|Clostridia	I	Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01847,ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
MMS3_k127_1254327_5	1304874.JAFY01000002_gene729	2.543e-54	205.0	COG0579@1|root,COG0579@2|Bacteria,3TAKI@508458|Synergistetes	508458|Synergistetes	C	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO,Fer2_BFD
MMS3_k127_1254327_8	266117.Rxyl_2678	1.192e-23	116.0	COG4122@1|root,COG4122@2|Bacteria,2IR7F@201174|Actinobacteria	201174|Actinobacteria	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_24
MMS3_k127_1254327_7	593750.Metfor_2416	4.545e-34	139.0	COG2102@1|root,arCOG00035@2157|Archaea,2XTNJ@28890|Euryarchaeota,2NAV9@224756|Methanomicrobia	224756|Methanomicrobia	S	Diphthamide synthase	-	-	6.3.1.14	ko:K06927	-	-	R03613	RC00358	ko00000,ko01000,ko03012	-	-	-	Diphthami_syn_2
MMS3_k127_1254327_2	224325.AF_1940	4.902e-191	626.0	COG0046@1|root,arCOG00641@2157|Archaea,2XU49@28890|Euryarchaeota,245S4@183980|Archaeoglobi	183980|Archaeoglobi	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
MMS3_k127_1254327_16	679926.Mpet_0716	0.0005285	46.0	COG1828@1|root,arCOG04462@2157|Archaea,2XYPB@28890|Euryarchaeota,2NA2T@224756|Methanomicrobia	224756|Methanomicrobia	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purS	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	PurS
MMS3_k127_1254327_4	525904.Tter_2104	2.164e-60	224.0	COG0500@1|root,COG2226@2|Bacteria,2NQ3S@2323|unclassified Bacteria	2|Bacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25,Methyltransf_31
MMS3_k127_1254327_15	673860.AciM339_0164	2.405e-07	54.0	arCOG05368@1|root,arCOG05368@2157|Archaea,2Y1EG@28890|Euryarchaeota,3F2W6@33867|unclassified Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_1254327_10	439481.Aboo_0646	2.979e-20	94.0	COG1522@1|root,arCOG01580@2157|Archaea,2Y746@28890|Euryarchaeota,3F3D8@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	Lrp/AsnC ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
MMS3_k127_1254327_12	439481.Aboo_0645	1.861e-16	88.0	COG1698@1|root,arCOG04308@2157|Archaea,2XZVX@28890|Euryarchaeota,3F2TA@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Uncharacterised protein family (UPF0147)	-	-	-	ko:K09721	-	-	-	-	ko00000	-	-	-	UPF0147
MMS3_k127_1254327_14	1094980.Mpsy_1005	2.071e-07	58.0	COG2012@1|root,arCOG04258@2157|Archaea,2Y0EY@28890|Euryarchaeota,2NA20@224756|Methanomicrobia	224756|Methanomicrobia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoH	-	2.7.7.6	ko:K03053	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb5_C
MMS3_k127_1254327_0	439481.Aboo_1091	0.0	1536.0	COG0085@1|root,arCOG01762@2157|Archaea,2XU1X@28890|Euryarchaeota,3F2FW@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB1	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03044,ko:K13798	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_4,RNA_pol_Rpb2_5,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
MMS3_k127_1254327_1	439481.Aboo_1090	0.0	1172.0	COG0086@1|root,arCOG04257@2157|Archaea,2XTBZ@28890|Euryarchaeota,3F2IK@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA1	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03041	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
MMS3_k127_1254327_3	673860.AciM339_1400	2.205e-100	369.0	COG0086@1|root,arCOG04256@2157|Archaea,2XTJ6@28890|Euryarchaeota,3F2IB@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA2	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03042	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	Intein_splicing,LAGLIDADG_3,RNA_pol_Rpb1_5
MMS3_k127_1254327_11	604354.TSIB_0391	5.763e-19	89.0	COG1911@1|root,arCOG01752@2157|Archaea,2Y0CU@28890|Euryarchaeota,244AG@183968|Thermococci	183968|Thermococci	J	structural constituent of ribosome	rpl30e	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02908	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L7Ae
MMS3_k127_1254327_6	1236689.MMALV_16400	9.213e-35	141.0	COG0195@1|root,arCOG01760@2157|Archaea,2Y6CH@28890|Euryarchaeota,3F2TQ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	Participates in transcription termination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_5
MMS3_k127_1254327_13	390989.JOEG01000011_gene258	4.062e-08	66.0	COG1011@1|root,COG1011@2|Bacteria,2GMZT@201174|Actinobacteria,4DAP1@85008|Micromonosporales	201174|Actinobacteria	S	Had-superfamily hydrolase, subfamily ia, variant 1	-	-	3.1.3.5	ko:K07025,ko:K08723	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2,Hydrolase_like
MMS3_k127_1365246_2	351160.RCIX823	6.053e-42	179.0	COG2409@1|root,arCOG02175@2157|Archaea,2XVKJ@28890|Euryarchaeota	28890|Euryarchaeota	S	MMPL family	-	-	-	ko:K06994	-	-	-	-	ko00000	-	-	-	MMPL
MMS3_k127_1365246_7	1459636.NTE_02837	7.773e-17	94.0	COG4742@1|root,arCOG04362@2157|Archaea,41SGE@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
MMS3_k127_1365246_3	1123248.KB893315_gene3016	1.292e-31	128.0	COG2764@1|root,COG2764@2|Bacteria,4NSNJ@976|Bacteroidetes,1ITJD@117747|Sphingobacteriia	976|Bacteroidetes	S	3-demethylubiquinone-9 3-methyltransferase	-	-	-	ko:K04750	-	-	-	-	ko00000	-	-	-	3-dmu-9_3-mt,Glyoxalase
MMS3_k127_1365246_5	1101195.Meth11DRAFT_0268	4.438e-22	109.0	COG5646@1|root,COG5646@2|Bacteria	2|Bacteria	S	Domain of unknown function (DU1801)	-	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DUF1801
MMS3_k127_1365246_1	1237500.ANBA01000009_gene1044	4.274e-64	246.0	COG3214@1|root,COG3214@2|Bacteria,2GJM7@201174|Actinobacteria,4EGXC@85012|Streptosporangiales	201174|Actinobacteria	S	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_42
MMS3_k127_1365246_8	1215092.PA6_020_01090	3.548e-16	86.0	COG3695@1|root,COG3695@2|Bacteria,1N7J2@1224|Proteobacteria,1SCIZ@1236|Gammaproteobacteria,1YGFX@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	L	6-O-methylguanine DNA methyltransferase, DNA binding domain	ybaZ	GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0005488,GO:0005515,GO:0019899,GO:0097159,GO:1901363	-	ko:K07443	-	-	-	-	ko00000	-	-	-	DNA_binding_1
MMS3_k127_1365246_4	368407.Memar_0227	1.654e-25	112.0	COG0526@1|root,arCOG01972@2157|Archaea,2XXRJ@28890|Euryarchaeota,2N9YG@224756|Methanomicrobia	224756|Methanomicrobia	O	Thioredoxin	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
MMS3_k127_1365246_9	273116.14324451	1.607e-06	55.0	arCOG05360@1|root,arCOG05360@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_1365246_6	797302.Halru_2885	4.636e-18	96.0	arCOG02274@1|root,arCOG02274@2157|Archaea,2XVHG@28890|Euryarchaeota,23SZN@183963|Halobacteria	183963|Halobacteria	K	DNA binding protein	-	-	-	ko:K06930	-	-	-	-	ko00000	-	-	-	HTH_10
MMS3_k127_1365246_0	446470.Snas_3349	2.969e-103	363.0	COG3420@1|root,COG3420@2|Bacteria,2I9HA@201174|Actinobacteria	201174|Actinobacteria	P	Right handed beta helix region	wcoB	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,DUF1565,NosD
MMS3_k127_1379457_1	523850.TON_0889	2.893e-30	138.0	COG0467@1|root,arCOG01171@2157|Archaea,2Y7MI@28890|Euryarchaeota,243IW@183968|Thermococci	183968|Thermococci	T	KaiC	-	-	-	-	-	-	-	-	-	-	-	-	ATPase
MMS3_k127_1379457_0	518766.Rmar_1238	3.508e-39	162.0	COG2222@1|root,COG2222@2|Bacteria,4NIX0@976|Bacteroidetes	976|Bacteroidetes	M	Bifunctional phosphoglucose phosphomannose isomerase	-	-	5.3.1.8,5.3.1.9	ko:K15916	ko00010,ko00030,ko00051,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R01819,R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	SIS,bact-PGI_C
MMS3_k127_1379457_2	448385.sce0435	2.225e-09	72.0	COG2128@1|root,COG2128@2|Bacteria,1RD1K@1224|Proteobacteria,42ZTP@68525|delta/epsilon subdivisions,2WV97@28221|Deltaproteobacteria,2YWVF@29|Myxococcales	28221|Deltaproteobacteria	O	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
MMS3_k127_1387319_2	1089553.Tph_c19560	2.486e-29	129.0	COG0095@1|root,COG0095@2|Bacteria,1V5KD@1239|Firmicutes,24PRV@186801|Clostridia	186801|Clostridia	H	Lipoate-protein ligase	-	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	-
MMS3_k127_1387319_7	748658.KB907319_gene787	2.695e-09	68.0	COG0509@1|root,COG0509@2|Bacteria,1NWR6@1224|Proteobacteria,1SPFA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	-	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
MMS3_k127_1387319_9	1457250.BBMO01000003_gene3193	0.0001119	53.0	COG2427@1|root,arCOG02113@2157|Archaea,2XWX9@28890|Euryarchaeota,23VYM@183963|Halobacteria	183963|Halobacteria	S	Protein of unknown function (DUF1641)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1641
MMS3_k127_1387319_0	1006006.Mcup_1723	3.145e-123	411.0	COG0446@1|root,arCOG01064@2157|Archaea,2XQ94@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
MMS3_k127_1387319_5	589924.Ferp_2460	1.341e-21	97.0	COG0425@1|root,arCOG02062@2157|Archaea,2XZUG@28890|Euryarchaeota,246G4@183980|Archaeoglobi	183980|Archaeoglobi	O	Sulfurtransferase TusA	-	-	-	-	-	-	-	-	-	-	-	-	TusA
MMS3_k127_1387319_3	399549.Msed_1549	1.985e-27	119.0	COG2210@1|root,arCOG02064@2157|Archaea,2XQYQ@28889|Crenarchaeota	28889|Crenarchaeota	S	DsrE/DsrF/DrsH-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE_2
MMS3_k127_1387319_4	926550.CLDAP_11590	1.279e-22	105.0	COG2210@1|root,COG2210@2|Bacteria,2G77F@200795|Chloroflexi	200795|Chloroflexi	S	DsrE/DsrF/DrsH-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE_2
MMS3_k127_1387319_6	546266.NEIMUCOT_04373	2.809e-18	87.0	COG0425@1|root,COG0425@2|Bacteria,1MZA5@1224|Proteobacteria,2VVW5@28216|Betaproteobacteria,2KRVZ@206351|Neisseriales	206351|Neisseriales	O	Belongs to the sulfur carrier protein TusA family	-	-	-	-	-	-	-	-	-	-	-	-	TusA
MMS3_k127_1387319_8	264732.Moth_0433	3.997e-08	59.0	COG1553@1|root,COG1553@2|Bacteria,1VG50@1239|Firmicutes,24R7R@186801|Clostridia,42H7U@68295|Thermoanaerobacterales	186801|Clostridia	P	DsrE/DsrF-like family	-	-	-	ko:K07235	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DrsE
MMS3_k127_1387319_1	1382306.JNIM01000001_gene721	2.283e-64	232.0	COG0489@1|root,COG0489@2|Bacteria,2G60P@200795|Chloroflexi	200795|Chloroflexi	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	-	-	-	ko:K03605	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DUF1858,ParA
MMS3_k127_1399287_4	1054217.TALC_00034	3.194e-71	245.0	COG0519@1|root,arCOG00085@2157|Archaea,2XT82@28890|Euryarchaeota,241KI@183967|Thermoplasmata	183967|Thermoplasmata	F	Catalyzes the synthesis of GMP from XMP	guaAB	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GMP_synt_C,NAD_synthase
MMS3_k127_1399287_9	439481.Aboo_0230	7.952e-09	59.0	arCOG02836@1|root,arCOG02836@2157|Archaea,2XYP5@28890|Euryarchaeota	28890|Euryarchaeota	K	transcriptional regulators containing the CopG Arc MetJ DNA-binding domain and a metal-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1
MMS3_k127_1399287_3	330214.NIDE2527	2.522e-83	301.0	COG2048@1|root,COG2048@2|Bacteria,3J175@40117|Nitrospirae	40117|Nitrospirae	C	Cysteine-rich domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K00241,ko:K03389	ko00020,ko00190,ko00650,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00356,M00357,M00374,M00376,M00563,M00567	R02164,R04540,R11928,R11931,R11943,R11944	RC00011,RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
MMS3_k127_1399287_6	330214.NIDE2517	3.451e-59	233.0	COG0479@1|root,COG0479@2|Bacteria,3J14K@40117|Nitrospirae	40117|Nitrospirae	C	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family	-	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_10
MMS3_k127_1399287_1	370438.PTH_1491	1.252e-177	574.0	COG1053@1|root,COG1053@2|Bacteria,1TPAR@1239|Firmicutes,247SY@186801|Clostridia,26024@186807|Peptococcaceae	186801|Clostridia	C	TIGRFAM succinate dehydrogenase or fumarate reductase, flavoprotein subunit	sdhA	-	1.3.5.1,1.3.5.4	ko:K00239,ko:K00244	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,ko05134,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020,map05134	M00009,M00011,M00149,M00150,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
MMS3_k127_1399287_5	386456.JQKN01000019_gene1317	9.456e-71	245.0	COG0638@1|root,arCOG00970@2157|Archaea,2XUIZ@28890|Euryarchaeota,23NYV@183925|Methanobacteria	183925|Methanobacteria	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	psmB	-	3.4.25.1	ko:K03433	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
MMS3_k127_1399287_0	1236689.MMALV_09200	5.511e-234	741.0	COG1782@1|root,arCOG00543@2157|Archaea,2XTIM@28890|Euryarchaeota,3F2GJ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	KH domain	epf2	-	-	ko:K07041	-	-	-	-	ko00000	-	-	-	Beta-Casp,KH_2,KH_7,Lactamase_B,Lactamase_B_6,RMMBL
MMS3_k127_1399287_7	1210908.HSB1_33340	1.751e-47	190.0	COG3379@1|root,arCOG01377@2157|Archaea,2XUWW@28890|Euryarchaeota,23RZ5@183963|Halobacteria	183963|Halobacteria	S	type I phosphodiesterase nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
MMS3_k127_1399287_8	929712.KI912613_gene3943	9.573e-20	102.0	COG0297@1|root,COG0297@2|Bacteria,2I2EE@201174|Actinobacteria,4CQI2@84995|Rubrobacteria	84995|Rubrobacteria	G	Starch synthase catalytic domain	-	-	2.4.1.11	ko:K16150	ko00500,ko01100,map00500,map01100	-	R00292	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT4	-	Glyco_transf_4,Glycos_transf_1
MMS3_k127_1399287_11	1530186.JQEY01000009_gene2943	0.000579	49.0	COG5482@1|root,COG5482@2|Bacteria,1MWIN@1224|Proteobacteria,2TS4R@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Putative PD-(D/E)XK phosphodiesterase (DUF2161)	MA20_28540	-	-	-	-	-	-	-	-	-	-	-	DUF2161
MMS3_k127_1399287_2	1211114.ALIP01000158_gene773	3.736e-102	357.0	COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,1RM89@1236|Gammaproteobacteria,1X4XY@135614|Xanthomonadales	135614|Xanthomonadales	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
MMS3_k127_1399287_10	593750.Metfor_1467	4.269e-05	48.0	COG0249@1|root,arCOG02897@2157|Archaea,2XT0M@28890|Euryarchaeota,2N9EU@224756|Methanomicrobia	224756|Methanomicrobia	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
MMS3_k127_1408303_2	1033806.HTIA_2724	1.081e-17	93.0	COG1733@1|root,arCOG01057@2157|Archaea,2XY55@28890|Euryarchaeota,23W7W@183963|Halobacteria	183963|Halobacteria	K	Transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
MMS3_k127_1408303_4	1227457.C451_16123	1.337e-06	61.0	COG2379@1|root,arCOG04170@2157|Archaea,2XSTZ@28890|Euryarchaeota,23SY7@183963|Halobacteria	183963|Halobacteria	G	Hydroxypyruvate reductase	-	-	2.7.1.165	ko:K11529	ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200	M00346	R08572	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4147,MOFRL
MMS3_k127_1408303_0	290397.Adeh_2479	4.371e-92	320.0	COG0665@1|root,COG2906@1|root,COG0665@2|Bacteria,COG2906@2|Bacteria,1MVM6@1224|Proteobacteria,42NTX@68525|delta/epsilon subdivisions,2WMFG@28221|Deltaproteobacteria,2YUM5@29|Myxococcales	28221|Deltaproteobacteria	E	Sarcosine oxidase	soxB	-	1.5.3.1	ko:K00303	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO,Fer2_BFD
MMS3_k127_1408303_3	404589.Anae109_1388	2.285e-12	80.0	COG0665@1|root,COG2906@1|root,COG0665@2|Bacteria,COG2906@2|Bacteria,1MVM6@1224|Proteobacteria,42NTX@68525|delta/epsilon subdivisions,2WMFG@28221|Deltaproteobacteria,2YUM5@29|Myxococcales	28221|Deltaproteobacteria	E	Sarcosine oxidase	soxB	-	1.5.3.1	ko:K00303	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO,Fer2_BFD
MMS3_k127_1408303_1	215803.DB30_2501	3.086e-35	153.0	COG0446@1|root,COG0446@2|Bacteria,1MVEK@1224|Proteobacteria,42XU1@68525|delta/epsilon subdivisions,2WSV4@28221|Deltaproteobacteria,2YUYW@29|Myxococcales	28221|Deltaproteobacteria	C	2Fe-2S iron-sulfur cluster binding domain	-	-	1.5.3.1	ko:K00302	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	Fer2_4,NAD_binding_8,Pyr_redox_2
MMS3_k127_1422305_2	926690.KE386573_gene2384	9.598e-25	109.0	COG1656@1|root,arCOG04290@2157|Archaea,2XXTT@28890|Euryarchaeota,23W3X@183963|Halobacteria	183963|Halobacteria	S	Mut7-C RNAse domain	-	-	-	ko:K09122	-	-	-	-	ko00000	-	-	-	Mut7-C
MMS3_k127_1422305_0	439481.Aboo_1538	4.092e-116	402.0	COG1109@1|root,arCOG00767@2157|Archaea,2XT1X@28890|Euryarchaeota,3F2G6@33867|unclassified Euryarchaeota	28890|Euryarchaeota	G	phosphoglucomutase phosphomannomutase alpha beta alpha domain I	pmm4	-	5.4.2.2,5.4.2.8	ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A2225	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
MMS3_k127_1422305_3	1297742.A176_02720	2.768e-19	101.0	COG1721@1|root,COG1721@2|Bacteria,1MXDI@1224|Proteobacteria	1224|Proteobacteria	S	conserved protein (some members contain a von Willebrand factor type A (vWA) domain)	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
MMS3_k127_1422305_1	562970.Btus_0260	2.5e-81	292.0	COG0714@1|root,COG0714@2|Bacteria,1TPKR@1239|Firmicutes,4HA0T@91061|Bacilli,27829@186823|Alicyclobacillaceae	91061|Bacilli	S	PFAM ATPase associated with various cellular activities AAA_3	yeaC	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
MMS3_k127_1455759_16	1054217.TALC_00633	7.287e-32	135.0	arCOG01806@1|root,arCOG01806@2157|Archaea,2Y0PI@28890|Euryarchaeota,242EI@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_1455759_7	1054217.TALC_00629	1.959e-77	271.0	COG0002@1|root,arCOG00495@2157|Archaea,2XTC1@28890|Euryarchaeota,2425Z@183967|Thermoplasmata	183967|Thermoplasmata	E	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily	-	-	1.2.1.38	ko:K00145,ko:K05829	ko00220,ko00300,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01130,map01210,map01230	M00028,M00031,M00763,M00845	R03443,R09777,R10931	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
MMS3_k127_1455759_5	429009.Adeg_1832	1.773e-90	323.0	COG1364@1|root,COG1364@2|Bacteria,1TPBP@1239|Firmicutes,2497Q@186801|Clostridia,42F14@68295|Thermoanaerobacterales	186801|Clostridia	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	argJ	-	2.3.1.1,2.3.1.35	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgJ
MMS3_k127_1455759_19	290317.Cpha266_1322	2.096e-24	120.0	COG0548@1|root,COG0548@2|Bacteria,1FDEU@1090|Chlorobi	1090|Chlorobi	F	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	-	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
MMS3_k127_1455759_1	644966.Tmar_0539	5.019e-138	450.0	COG0137@1|root,COG0137@2|Bacteria,1TP3X@1239|Firmicutes,247MF@186801|Clostridia,3WCR7@538999|Clostridiales incertae sedis	186801|Clostridia	H	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	-	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
MMS3_k127_1455759_6	1408418.JNJH01000010_gene3454	3.601e-80	288.0	COG0165@1|root,COG0165@2|Bacteria,1MUTU@1224|Proteobacteria,2TR4H@28211|Alphaproteobacteria,2JPHA@204441|Rhodospirillales	204441|Rhodospirillales	E	argininosuccinate lyase	argH	-	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
MMS3_k127_1455759_15	1236689.MMALV_06180	2.139e-34	144.0	arCOG01806@1|root,arCOG01806@2157|Archaea,2Y0PI@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	ACT_7
MMS3_k127_1455759_11	399549.Msed_2203	4.862e-66	256.0	COG0747@1|root,arCOG01533@2157|Archaea	2157|Archaea	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	PKD,SBP_bac_5
MMS3_k127_1455759_4	368408.Tpen_0950	1.09e-90	317.0	COG0016@1|root,arCOG00410@2157|Archaea,2XPR2@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily	pheS	GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HTH_DeoR,TrmB,tRNA-synt_2d
MMS3_k127_1455759_14	1198449.ACAM_1444	1.309e-39	168.0	COG0072@1|root,arCOG00412@2157|Archaea,2XPRQ@28889|Crenarchaeota	28889|Crenarchaeota	J	Phenylalanyl-tRNA synthetase, beta subunit	pheT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,tRNA-synt_2d
MMS3_k127_1455759_0	562970.Btus_1313	6.245e-177	588.0	COG1884@1|root,COG1884@2|Bacteria,1TQAD@1239|Firmicutes,4H9QB@91061|Bacilli,277YF@186823|Alicyclobacillaceae	91061|Bacilli	I	Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
MMS3_k127_1455759_17	203275.BFO_0966	1.976e-26	127.0	COG0346@1|root,COG0346@2|Bacteria,4NNGG@976|Bacteroidetes,2FRZS@200643|Bacteroidia,22XX8@171551|Porphyromonadaceae	976|Bacteroidetes	E	methylmalonyl-CoA epimerase	mce	-	5.1.99.1	ko:K05606	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R02765,R09979	RC00780,RC02739	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase_4
MMS3_k127_1455759_3	439481.Aboo_1303	5.669e-93	329.0	COG0148@1|root,arCOG01169@2157|Archaea,2XSXT@28890|Euryarchaeota,3F2J7@33867|unclassified Euryarchaeota	28890|Euryarchaeota	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
MMS3_k127_1455759_8	1054217.TALC_00169	1.039e-76	263.0	COG0052@1|root,arCOG04245@2157|Archaea,2XTHM@28890|Euryarchaeota,241MQ@183967|Thermoplasmata	183967|Thermoplasmata	J	Belongs to the universal ribosomal protein uS2 family	rps2	-	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
MMS3_k127_1455759_20	1459636.NTE_02339	7.667e-17	93.0	COG1378@1|root,arCOG02037@2157|Archaea	2157|Archaea	K	Transcriptional regulator, TrmB	-	-	-	-	-	-	-	-	-	-	-	-	TrmB
MMS3_k127_1455759_9	1236689.MMALV_00330	8.831e-69	248.0	COG1405@1|root,arCOG01981@2157|Archaea,2XT0Z@28890|Euryarchaeota,3F2FH@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	tfb	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
MMS3_k127_1455759_18	1184607.AUCHE_05_00490	1.848e-24	117.0	COG2887@1|root,COG2887@2|Bacteria,2GJC5@201174|Actinobacteria,4F7JM@85018|Dermatophilaceae	201174|Actinobacteria	L	Protein of unknown function (DUF2800)	recB	-	-	ko:K07465	-	-	-	-	ko00000	-	-	-	PDDEXK_1
MMS3_k127_1455759_2	1094980.Mpsy_1916	2.215e-129	422.0	COG1759@1|root,arCOG04346@2157|Archaea,2XUFR@28890|Euryarchaeota,2N9G6@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'- monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1- beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates	purP	-	6.3.4.23	ko:K06863	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R06975	RC00263,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1246,DUF1297
MMS3_k127_1455759_10	1459636.NTE_02001	1.308e-67	241.0	COG1131@1|root,arCOG00194@2157|Archaea	2157|Archaea	V	ABC-type multidrug transport system ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
MMS3_k127_1455759_13	273075.Ta0642	2.196e-48	193.0	COG0842@1|root,arCOG01469@2157|Archaea,2Y1TJ@28890|Euryarchaeota	28890|Euryarchaeota	V	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
MMS3_k127_1455759_21	525904.Tter_2363	4.552e-15	83.0	COG1956@1|root,COG1956@2|Bacteria,2NPKF@2323|unclassified Bacteria	2|Bacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	yebR	-	1.8.4.14	ko:K08968	ko00270,map00270	-	R02025	RC00639	ko00000,ko00001,ko01000	-	-	-	GAF,GAF_2
MMS3_k127_1455759_12	456442.Mboo_1665	1.37e-53	200.0	COG1701@1|root,arCOG04262@2157|Archaea,2XTAP@28890|Euryarchaeota,2N9DE@224756|Methanomicrobia	224756|Methanomicrobia	S	Pfam:DUF137	-	-	6.3.2.36	ko:K09722	ko00410,ko00770,ko01100,map00410,map00770,map01100	-	R09379	RC00096,RC00141	ko00000,ko00001,ko01000	-	-	-	PPS_PS
MMS3_k127_1464134_6	1379698.RBG1_1C00001G1221	1e-13	79.0	COG0620@1|root,COG0620@2|Bacteria	2|Bacteria	E	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation	-	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_1,Meth_synt_2
MMS3_k127_1464134_0	266117.Rxyl_0841	3.33e-91	322.0	COG0620@1|root,COG0620@2|Bacteria,2GIXA@201174|Actinobacteria,4CQIC@84995|Rubrobacteria	84995|Rubrobacteria	H	Cobalamin-independent synthase, Catalytic domain	-	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
MMS3_k127_1464134_1	273057.SSO2047	3.077e-74	276.0	arCOG00144@1|root,arCOG00144@2157|Archaea,2XQYU@28889|Crenarchaeota	28889|Crenarchaeota	G	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
MMS3_k127_1464134_3	673860.AciM339_0309	3.644e-59	215.0	COG0024@1|root,arCOG01001@2157|Archaea,2XT8G@28890|Euryarchaeota,3F2K9@33867|unclassified Euryarchaeota	28890|Euryarchaeota	E	Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val)	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
MMS3_k127_1464134_5	415426.Hbut_0770	7.985e-32	138.0	COG0009@1|root,arCOG01952@2157|Archaea,2XPW0@28889|Crenarchaeota	28889|Crenarchaeota	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine	sua5	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	SUA5,Sua5_yciO_yrdC
MMS3_k127_1464134_4	351160.LRC143	6.092e-52	189.0	COG0105@1|root,arCOG04313@2157|Archaea,2XWSK@28890|Euryarchaeota,2N9MF@224756|Methanomicrobia	224756|Methanomicrobia	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	-	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	iAF692.Mbar_A3385	NDK
MMS3_k127_1464134_2	1254432.SCE1572_34735	5.94e-65	233.0	COG0500@1|root,COG2226@2|Bacteria,1REKQ@1224|Proteobacteria,43DEY@68525|delta/epsilon subdivisions,2X8KX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
MMS3_k127_1480513_6	1047013.AQSP01000122_gene2223	2.596e-21	106.0	COG3291@1|root,COG3291@2|Bacteria,2NQ6Y@2323|unclassified Bacteria	2|Bacteria	M	PKD domain	-	-	3.2.1.91	ko:K19668	ko00500,ko01100,ko02020,map00500,map01100,map02020	-	R02886,R11308	RC00799	ko00000,ko00001,ko01000	-	GH6	-	CBM_2,CHU_C,FlgD_ig,Glyco_hydro_6,PKD,VCBS
MMS3_k127_1480513_1	439481.Aboo_0430	4.184e-129	422.0	COG0468@1|root,arCOG00415@2157|Archaea,2XT80@28890|Euryarchaeota,3F2HE@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules	radA	GO:0000150,GO:0000217,GO:0000400,GO:0000724,GO:0000725,GO:0000730,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003697,GO:0003824,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006312,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022607,GO:0033554,GO:0034622,GO:0034641,GO:0042148,GO:0042623,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0045003,GO:0046483,GO:0050896,GO:0051716,GO:0065003,GO:0065004,GO:0071704,GO:0071824,GO:0071840,GO:0090304,GO:0090735,GO:0097159,GO:0140097,GO:1901360,GO:1901363	-	ko:K04483	-	-	-	-	ko00000,ko03400	-	-	-	HHH_5,Intein_splicing,Rad51
MMS3_k127_1480513_2	1236689.MMALV_05760	9.882e-97	325.0	COG0152@1|root,arCOG04421@2157|Archaea,2XTW4@28890|Euryarchaeota,3F2G7@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	SAICAR synthetase	purC	-	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
MMS3_k127_1480513_4	572478.Vdis_0835	2.853e-34	152.0	COG0454@1|root,arCOG00826@2157|Archaea,2XR3W@28889|Crenarchaeota	28889|Crenarchaeota	K	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
MMS3_k127_1480513_0	397948.Cmaq_0373	1.727e-150	502.0	COG0281@1|root,arCOG00853@2157|Archaea,2XPUQ@28889|Crenarchaeota	28889|Crenarchaeota	C	malic enzyme	-	-	1.1.1.38,1.1.1.40	ko:K00027,ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,ko02020,map00620,map00710,map01100,map01120,map01200,map02020	M00169,M00172	R00214,R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	Malic_M,malic
MMS3_k127_1480513_7	1128421.JAGA01000003_gene2937	5.745e-16	91.0	COG0476@1|root,COG0476@2|Bacteria,2NPX3@2323|unclassified Bacteria	2|Bacteria	H	ThiF family	moeB	-	2.7.7.73,2.7.7.80,2.8.1.11	ko:K03148,ko:K21029,ko:K21147	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07459,R07461	RC00043	ko00000,ko00001,ko01000	-	-	-	Rhodanese,ThiF
MMS3_k127_1480513_3	1382356.JQMP01000001_gene880	2.2e-38	160.0	COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,2G84K@200795|Chloroflexi,27XSV@189775|Thermomicrobia	189775|Thermomicrobia	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B,Rhodanese
MMS3_k127_1480513_5	266117.Rxyl_0842	6.199e-22	99.0	COG0620@1|root,COG0620@2|Bacteria	2|Bacteria	E	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation	-	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_1,Meth_synt_2
MMS3_k127_151240_0	1236689.MMALV_12140	1.906e-124	407.0	COG0574@1|root,arCOG01111@2157|Archaea,2XU2T@28890|Euryarchaeota,3F2MC@33867|unclassified Euryarchaeota	28890|Euryarchaeota	G	PEP-utilising enzyme, mobile domain	-	-	2.7.9.1,2.7.9.2	ko:K01006,ko:K01007	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173,M00374	R00199,R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
MMS3_k127_151240_1	439481.Aboo_0010	1.628e-18	102.0	COG1361@1|root,COG1572@1|root,arCOG01917@1|root,arCOG01917@2157|Archaea,arCOG02079@2157|Archaea,arCOG02532@2157|Archaea,2Y1TH@28890|Euryarchaeota,3F2UJ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	M	Double zinc ribbon	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,DZR,zinc_ribbon_2
MMS3_k127_1533440_4	304371.MCP_1884	2.372e-54	205.0	COG0704@1|root,arCOG00318@2157|Archaea,2XUA4@28890|Euryarchaeota,2N9P3@224756|Methanomicrobia	224756|Methanomicrobia	K	Phosphate uptake regulator, PhoU	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin,PhoU
MMS3_k127_1533440_0	263820.PTO0093	1.416e-113	392.0	COG0477@1|root,arCOG02682@2157|Archaea,2XWP6@28890|Euryarchaeota,24240@183967|Thermoplasmata	28890|Euryarchaeota	G	Sugar (and other) transporter	-	-	-	ko:K08176,ko:K08368,ko:K08369	-	-	-	-	ko00000,ko02000	2.A.1,2.A.1.9	-	-	MFS_1,Sugar_tr
MMS3_k127_1533440_3	926569.ANT_14660	8.603e-63	230.0	COG1454@1|root,COG1454@2|Bacteria,2G6IU@200795|Chloroflexi	200795|Chloroflexi	C	PFAM iron-containing alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Fe-ADH
MMS3_k127_1533440_9	1123388.AQWU01000053_gene1553	0.0006068	47.0	COG0735@1|root,COG0735@2|Bacteria,1WJXU@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	Belongs to the Fur family	-	-	-	ko:K03711,ko:K09825	-	-	-	-	ko00000,ko03000	-	-	-	FUR
MMS3_k127_1533440_7	1408424.JHYI01000011_gene1367	1.296e-30	140.0	COG0454@1|root,COG0456@2|Bacteria,1V4GU@1239|Firmicutes,4HKA1@91061|Bacilli	91061|Bacilli	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
MMS3_k127_1533440_8	1131266.ARWQ01000001_gene1344	7.118e-23	113.0	COG3263@1|root,arCOG01962@2157|Archaea,41SV3@651137|Thaumarchaeota	651137|Thaumarchaeota	P	Sodium hydrogen exchanger	-	-	-	ko:K11105	-	-	-	-	ko00000,ko02000	2.A.36.6	-	-	Na_H_Exchanger
MMS3_k127_1533440_6	192952.MM_2637	7.966e-31	137.0	COG0668@1|root,arCOG01568@2157|Archaea,2XSU5@28890|Euryarchaeota	28890|Euryarchaeota	M	COG0668 Small-conductance mechanosensitive channel	mscS1	-	-	ko:K16052	-	-	-	-	ko00000,ko02000	1.A.23.4	-	-	MS_channel
MMS3_k127_1533440_1	1382306.JNIM01000001_gene2270	1.241e-104	364.0	COG0038@1|root,COG0038@2|Bacteria,2G7G9@200795|Chloroflexi	200795|Chloroflexi	P	Voltage gated chloride channel	-	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	-	CBS,TrkA_C,Voltage_CLC
MMS3_k127_1533440_5	591159.ACEZ01000206_gene7046	1.075e-41	162.0	COG1247@1|root,COG1247@2|Bacteria,2II0A@201174|Actinobacteria	201174|Actinobacteria	M	-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_1533440_2	479434.Sthe_1089	2.235e-76	274.0	COG3280@1|root,COG3280@2|Bacteria,2G7QP@200795|Chloroflexi,27YWA@189775|Thermomicrobia	189775|Thermomicrobia	G	Alpha amylase, catalytic domain	-	-	5.4.99.15	ko:K06044	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R01824,R09995	-	ko00000,ko00001,ko00002,ko01000	-	GH13	-	Alpha-amylase
MMS3_k127_1534853_2	1459636.NTE_03333	6.865e-11	72.0	COG1733@1|root,arCOG01057@2157|Archaea	2157|Archaea	K	Transcriptional regulator	-	-	-	ko:K07332	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	-
MMS3_k127_1534853_0	673860.AciM339_0537	7.111e-47	189.0	COG0470@1|root,arCOG00470@2157|Archaea,2XT81@28890|Euryarchaeota,3F2FB@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA	rfcL	-	-	ko:K04800	ko03030,map03030	-	-	-	ko00000,ko00001,ko03032	-	-	-	AAA,Rad17
MMS3_k127_1534853_3	42256.RradSPS_2139	1.28e-05	58.0	COG0667@1|root,COG0667@2|Bacteria,2GJBG@201174|Actinobacteria,4CPGS@84995|Rubrobacteria	84995|Rubrobacteria	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
MMS3_k127_1534853_1	397948.Cmaq_0228	4.675e-36	143.0	COG1225@1|root,arCOG00310@2157|Archaea,2XQNS@28889|Crenarchaeota	28889|Crenarchaeota	O	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
MMS3_k127_1557638_0	429009.Adeg_1102	5.136e-124	409.0	COG0473@1|root,COG0473@2|Bacteria,1TPEM@1239|Firmicutes,24A63@186801|Clostridia,42EVK@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM isocitrate isopropylmalate dehydrogenase	icd	-	1.1.1.41	ko:K00030	ko00020,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010	R00709	RC00114	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
MMS3_k127_1557638_1	246197.MXAN_2547	7.116e-59	210.0	COG0432@1|root,COG0432@2|Bacteria,1RA5G@1224|Proteobacteria,42QZ8@68525|delta/epsilon subdivisions,2WMV9@28221|Deltaproteobacteria,2YUYA@29|Myxococcales	28221|Deltaproteobacteria	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
MMS3_k127_1561254_2	42256.RradSPS_2508	1.304e-36	150.0	COG0586@1|root,COG0586@2|Bacteria,2GN43@201174|Actinobacteria,4CSZP@84995|Rubrobacteria	84995|Rubrobacteria	S	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
MMS3_k127_1561254_0	1054217.TALC_01269	7.311e-71	260.0	COG0044@1|root,arCOG00689@2157|Archaea,2XTQU@28890|Euryarchaeota,241MY@183967|Thermoplasmata	183967|Thermoplasmata	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	pyrC	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
MMS3_k127_1561254_1	693661.Arcve_1000	8.102e-63	231.0	COG0150@1|root,arCOG00639@2157|Archaea,2XTBA@28890|Euryarchaeota,245YB@183980|Archaeoglobi	183980|Archaeoglobi	F	Phosphoribosylformylglycinamidine cyclo-ligase	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
MMS3_k127_1561254_3	675635.Psed_4602	2.402e-05	57.0	COG0697@1|root,COG0697@2|Bacteria,2GVE1@201174|Actinobacteria,4E3UP@85010|Pseudonocardiales	201174|Actinobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
MMS3_k127_1564464_7	456442.Mboo_1987	1.214e-56	219.0	COG0301@1|root,arCOG00038@2157|Archaea,2XYMB@28890|Euryarchaeota,2NBHY@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	-	-	2.8.1.4	ko:K03151	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07461	-	ko00000,ko00001,ko01000,ko03016	-	-	-	ThiI
MMS3_k127_1564464_11	640510.BC1001_0207	3.577e-36	147.0	COG2021@1|root,COG2021@2|Bacteria,1QU84@1224|Proteobacteria,2VRYJ@28216|Betaproteobacteria,1K0JE@119060|Burkholderiaceae	28216|Betaproteobacteria	E	PFAM alpha beta hydrolase fold	-	-	3.1.1.24	ko:K01055	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00568	R02991	RC00825	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1
MMS3_k127_1564464_5	562970.Btus_2106	7.684e-73	259.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1U2YN@1239|Firmicutes,4HX7V@91061|Bacilli,27A4T@186823|Alicyclobacillaceae	91061|Bacilli	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3
MMS3_k127_1564464_14	1056820.KB900696_gene4002	7.055e-17	88.0	COG0494@1|root,COG0494@2|Bacteria,1RD2C@1224|Proteobacteria,1SA4Q@1236|Gammaproteobacteria,2PNVT@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	L	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
MMS3_k127_1564464_10	386456.JQKN01000017_gene841	6.413e-37	154.0	arCOG12322@1|root,arCOG12322@2157|Archaea,2Y5I1@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_1564464_12	469383.Cwoe_4461	3.461e-30	134.0	COG3173@1|root,COG3173@2|Bacteria	2|Bacteria	S	very-long-chain-acyl-CoA dehydrogenase activity	-	-	2.7.1.190	ko:K17910	-	-	R11229	RC00002,RC00078	ko00000,ko01000,ko01504	-	-	-	APH
MMS3_k127_1564464_4	1236689.MMALV_07170	2.957e-73	250.0	COG2101@1|root,arCOG01764@2157|Archaea,2XTTR@28890|Euryarchaeota,3F2KX@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation	tbp	-	-	ko:K03120	ko03022,ko05016,ko05165,ko05166,ko05168,ko05169,ko05203,map03022,map05016,map05165,map05166,map05168,map05169,map05203	-	-	-	ko00000,ko00001,ko03000,ko03021	-	-	-	TBP
MMS3_k127_1564464_9	439481.Aboo_0370	1.374e-39	158.0	COG1831@1|root,arCOG00893@2157|Archaea,2XTX7@28890|Euryarchaeota,3F2KE@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	TatD related DNase	tatD	-	-	ko:K07049	-	-	-	-	ko00000	-	-	-	TatD_DNase
MMS3_k127_1564464_15	360094.PXO_02846	1.33e-12	81.0	COG0125@1|root,COG0125@2|Bacteria,1MV9C@1224|Proteobacteria,1SWJN@1236|Gammaproteobacteria,1X61K@135614|Xanthomonadales	135614|Xanthomonadales	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
MMS3_k127_1564464_13	1184251.TCELL_0086	1.54e-22	113.0	COG1474@1|root,arCOG00467@2157|Archaea,2XPZB@28889|Crenarchaeota	28889|Crenarchaeota	L	Involved in regulation of DNA replication	cdc6-2	-	-	ko:K10725	-	-	-	-	ko00000,ko03032	-	-	-	AAA_22,Cdc6_C
MMS3_k127_1564464_3	349124.Hhal_0116	2.387e-96	324.0	COG0320@1|root,COG0320@2|Bacteria,1MVRD@1224|Proteobacteria,1RMAT@1236|Gammaproteobacteria,1WXEN@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	-	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
MMS3_k127_1564464_6	931277.C448_02513	1.992e-68	261.0	COG1746@1|root,arCOG04249@2157|Archaea,2XT5J@28890|Euryarchaeota,23SC2@183963|Halobacteria	183963|Halobacteria	J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate	cca	-	2.7.7.72	ko:K07558	-	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko01000,ko03016	-	-	-	NTP_transf_2,tRNA_NucTransf2
MMS3_k127_1564464_2	572478.Vdis_1794	2.886e-114	403.0	COG1180@1|root,arCOG00946@2157|Archaea,2XPTQ@28889|Crenarchaeota	28889|Crenarchaeota	C	PFAM Radical SAM domain protein	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Radical_SAM
MMS3_k127_1564464_0	1500897.JQNA01000002_gene1522	9.193e-259	839.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2VNZQ@28216|Betaproteobacteria,1KGKU@119060|Burkholderiaceae	28216|Betaproteobacteria	P	E1-E2 ATPase	-	-	3.6.3.6	ko:K01535	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.3.3	-	-	Cation_ATPase_N,E1-E2_ATPase,Hydrolase
MMS3_k127_1564464_8	525904.Tter_2354	1.194e-51	188.0	COG2080@1|root,COG2080@2|Bacteria,2NPPX@2323|unclassified Bacteria	2|Bacteria	C	PFAM 2Fe-2S -binding	iorA	-	1.2.5.3,1.3.99.16	ko:K00256,ko:K03518,ko:K07302,ko:K07303,ko:K13483	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103,R11168	RC00143,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2,Fer2_2
MMS3_k127_1564464_1	1340493.JNIF01000003_gene2232	2.25e-164	550.0	COG1529@1|root,COG1529@2|Bacteria,3Y3J7@57723|Acidobacteria	57723|Acidobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.3.99.16	ko:K00256	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
MMS3_k127_1566622_10	439481.Aboo_0090	1.672e-19	91.0	COG1873@1|root,arCOG02155@2157|Archaea,2Y75P@28890|Euryarchaeota,3F3FQ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	PRC-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	PRC
MMS3_k127_1566622_0	439481.Aboo_0814	1.966e-166	546.0	COG1793@1|root,arCOG01347@2157|Archaea,2XTCK@28890|Euryarchaeota,3F2GX@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair	lig	-	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N
MMS3_k127_1566622_5	1347369.CCAD010000041_gene766	5.82e-54	198.0	COG0036@1|root,COG0036@2|Bacteria,1TQK8@1239|Firmicutes,4H9RW@91061|Bacilli,1ZCUF@1386|Bacillus	91061|Bacilli	G	Belongs to the ribulose-phosphate 3-epimerase family	rpe	GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046496,GO:0046872,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
MMS3_k127_1566622_8	1056495.Calag_0348	1.245e-38	168.0	COG0747@1|root,arCOG01533@2157|Archaea,2XSNM@28889|Crenarchaeota	28889|Crenarchaeota	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	PKD,SBP_bac_5
MMS3_k127_1566622_2	1051632.TPY_0985	1.479e-116	387.0	COG4608@1|root,COG4608@2|Bacteria,1V36J@1239|Firmicutes,24C3R@186801|Clostridia,3WCUJ@538999|Clostridiales incertae sedis	186801|Clostridia	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
MMS3_k127_1566622_3	292459.STH2824	1.138e-82	295.0	COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,247NN@186801|Clostridia	186801|Clostridia	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031,ko:K02032,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
MMS3_k127_1566622_7	1116369.KB890026_gene5450	1.209e-41	168.0	COG1173@1|root,COG1173@2|Bacteria,1MW3R@1224|Proteobacteria,2TUCW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EP	ABC-type dipeptide oligopeptide nickel transport systems, permease components	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1,OppC_N
MMS3_k127_1566622_6	1028801.RG1141_CH28700	3.179e-46	183.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TQKK@28211|Alphaproteobacteria,4BB7F@82115|Rhizobiaceae	28211|Alphaproteobacteria	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
MMS3_k127_1566622_9	69014.TK2300	6.791e-25	113.0	COG1990@1|root,arCOG04228@2157|Archaea,2XYRE@28890|Euryarchaeota,24457@183968|Thermococci	183968|Thermococci	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	-	3.1.1.29	ko:K04794	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	PTH2
MMS3_k127_1566622_1	673860.AciM339_0085	4.946e-146	475.0	COG0541@1|root,arCOG01228@2157|Archaea,2XTWX@28890|Euryarchaeota,3F2HD@33867|unclassified Euryarchaeota	28890|Euryarchaeota	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	srp54	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
MMS3_k127_1566622_4	498761.HM1_0290	1.994e-81	289.0	COG0493@1|root,COG0493@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia	186801|Clostridia	C	'glutamate synthase	gltA	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
MMS3_k127_1566622_11	1051632.TPY_2558	5.55e-07	61.0	COG4934@1|root,COG4934@2|Bacteria,1UYFY@1239|Firmicutes	1239|Firmicutes	O	Peptidase S53 propeptide	-	-	-	ko:K08677	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_S8,Pro-kuma_activ
MMS3_k127_1590965_4	671065.MetMK1DRAFT_00005900	2.441e-11	73.0	arCOG03768@1|root,arCOG03768@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF973
MMS3_k127_1590965_2	383372.Rcas_3678	2.177e-56	210.0	COG1028@1|root,COG1028@2|Bacteria,2G660@200795|Chloroflexi,376R3@32061|Chloroflexia	32061|Chloroflexia	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
MMS3_k127_1590965_0	644966.Tmar_1718	1.369e-76	269.0	COG1028@1|root,COG1028@2|Bacteria,1TR53@1239|Firmicutes,247XS@186801|Clostridia	186801|Clostridia	IQ	Dehydrogenase	ydaD	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
MMS3_k127_1590965_1	1457250.BBMO01000002_gene2982	1.777e-63	235.0	COG1506@1|root,arCOG01646@2157|Archaea,2XU9I@28890|Euryarchaeota,23RYH@183963|Halobacteria	183963|Halobacteria	E	COG1506 Dipeptidyl aminopeptidases acylaminoacyl-peptidases	pop	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9,Peptidase_S9_N
MMS3_k127_1590965_3	42256.RradSPS_0187	1.057e-41	172.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,2GJW4@201174|Actinobacteria,4CQV5@84995|Rubrobacteria	84995|Rubrobacteria	EU	Peptidase S9, prolyl oligopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
MMS3_k127_1626455_3	1047013.AQSP01000122_gene2223	1.091e-13	79.0	COG3291@1|root,COG3291@2|Bacteria,2NQ6Y@2323|unclassified Bacteria	2|Bacteria	M	PKD domain	-	-	3.2.1.91	ko:K19668	ko00500,ko01100,ko02020,map00500,map01100,map02020	-	R02886,R11308	RC00799	ko00000,ko00001,ko01000	-	GH6	-	CBM_2,CHU_C,FlgD_ig,Glyco_hydro_6,PKD,VCBS
MMS3_k127_1626455_0	1307759.JOMJ01000003_gene1973	8.279e-72	256.0	COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,42MTX@68525|delta/epsilon subdivisions,2WITE@28221|Deltaproteobacteria,2M8SG@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	Belongs to the DegT DnrJ EryC1 family	pseC	-	2.6.1.102	ko:K13010	ko00520,map00520	-	R10460	RC00006,RC00781	ko00000,ko00001,ko01000,ko01005,ko01007	-	-	-	DegT_DnrJ_EryC1
MMS3_k127_1626455_2	1121957.ATVL01000006_gene3205	7.171e-41	161.0	COG1011@1|root,COG1011@2|Bacteria	2|Bacteria	S	phosphatase activity	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
MMS3_k127_1626455_1	186497.PF0160	2.873e-55	215.0	COG1530@1|root,arCOG00321@2157|Archaea,2XU9U@28890|Euryarchaeota,24370@183968|Thermococci	183968|Thermococci	L	Putative modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
MMS3_k127_1631302_6	1128398.Curi_c18280	2.011e-40	156.0	COG0443@1|root,COG0443@2|Bacteria,1TP1J@1239|Firmicutes,248QV@186801|Clostridia,267XS@186813|unclassified Clostridiales	186801|Clostridia	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
MMS3_k127_1631302_1	1120973.AQXL01000087_gene3222	1.001e-88	312.0	COG0372@1|root,COG0372@2|Bacteria,1TPPS@1239|Firmicutes,4HDG0@91061|Bacilli,277YE@186823|Alicyclobacillaceae	91061|Bacilli	C	Citrate synthase, C-terminal domain	citA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
MMS3_k127_1631302_7	368407.Memar_0230	6.215e-10	63.0	COG1958@1|root,arCOG00998@2157|Archaea,2XZTF@28890|Euryarchaeota,2NA2C@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM Like-Sm ribonucleoprotein, core	-	-	-	ko:K04796	-	-	-	-	ko00000	-	-	-	LSM
MMS3_k127_1631302_5	268739.Nmlp_1367	2.861e-45	177.0	COG1339@1|root,arCOG01904@2157|Archaea,2XTFW@28890|Euryarchaeota,23SYJ@183963|Halobacteria	183963|Halobacteria	H	Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN)	ribK	-	2.7.1.161	ko:K07732	ko00740,ko01100,map00740,map01100	-	R08574	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	CTP-dep_RFKase,HTH_20
MMS3_k127_1631302_2	673860.AciM339_0248	1.283e-76	269.0	COG1244@1|root,arCOG01360@2157|Archaea,2XT5Q@28890|Euryarchaeota,3F2I0@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Elongator protein 3, MiaB family, Radical SAM	-	-	-	ko:K06936	-	-	-	-	ko00000	-	-	-	Radical_SAM
MMS3_k127_1631302_4	397948.Cmaq_1108	5.799e-55	214.0	COG0171@1|root,arCOG00069@2157|Archaea,2XQ3J@28889|Crenarchaeota	28889|Crenarchaeota	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source	nadE	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.1.5	ko:K01916	ko00760,ko01100,map00760,map01100	M00115	R00189	RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	NAD_synthase
MMS3_k127_1631302_3	1236689.MMALV_14300	6.873e-57	209.0	arCOG04990@1|root,arCOG04990@2157|Archaea,2XYVI@28890|Euryarchaeota	28890|Euryarchaeota	S	Protein of unknown function TPD sequence-motif	-	-	-	-	-	-	-	-	-	-	-	-	TPD
MMS3_k127_1631302_0	1041930.Mtc_2357	3.076e-89	309.0	COG0124@1|root,arCOG00404@2157|Archaea,2XSYX@28890|Euryarchaeota,2N9BW@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the class-II aminoacyl-tRNA synthetase family	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
MMS3_k127_1638530_6	673860.AciM339_0113	4.493e-77	268.0	COG0281@1|root,arCOG01331@2157|Archaea,2XTRZ@28890|Euryarchaeota,3F36G@33867|unclassified Euryarchaeota	28890|Euryarchaeota	O	Peptidase family M48	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
MMS3_k127_1638530_7	673860.AciM339_0076	1.886e-70	260.0	COG1571@1|root,arCOG01115@2157|Archaea,2XTGD@28890|Euryarchaeota,3F2IS@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA	tiaS	GO:0002097,GO:0002101,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016879,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360	6.3.4.22	ko:K06932	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1743,tRNA_anti-codon
MMS3_k127_1638530_8	698757.Pogu_0973	1.701e-57	228.0	COG1013@1|root,arCOG01599@2157|Archaea,2XPQG@28889|Crenarchaeota	28889|Crenarchaeota	C	TIGRFAM pyruvate ferredoxin flavodoxin oxidoreductase, beta subunit	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFO_beta_C,TPP_enzyme_C
MMS3_k127_1638530_2	644966.Tmar_1368	1.18e-115	394.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1TSSC@1239|Firmicutes,248I6@186801|Clostridia,3WDC4@538999|Clostridiales incertae sedis	186801|Clostridia	C	TIGRFAM 2-oxoacid acceptor oxidoreductase, alpha subunit	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
MMS3_k127_1638530_5	410359.Pcal_1604	9.483e-91	316.0	COG0119@1|root,arCOG02092@2157|Archaea,2XPY3@28889|Crenarchaeota	28889|Crenarchaeota	E	Belongs to the alpha-IPM synthase homocitrate synthase family	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
MMS3_k127_1638530_1	868131.MSWAN_2314	3.901e-121	407.0	COG0065@1|root,arCOG01698@2157|Archaea,2XTWH@28890|Euryarchaeota,23PD9@183925|Methanobacteria	183925|Methanobacteria	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
MMS3_k127_1638530_9	1158345.JNLL01000001_gene1438	1.964e-40	169.0	COG0066@1|root,COG0066@2|Bacteria,2G405@200783|Aquificae	200783|Aquificae	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
MMS3_k127_1638530_4	502025.Hoch_6339	4.375e-113	392.0	COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,42M8G@68525|delta/epsilon subdivisions,2WIYB@28221|Deltaproteobacteria,2YZ2Q@29|Myxococcales	28221|Deltaproteobacteria	C	Dehydrogenase	-	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
MMS3_k127_1638530_3	797299.HALLA_04740	8.105e-115	400.0	COG0183@1|root,arCOG01278@2157|Archaea,2XVUA@28890|Euryarchaeota,23TVK@183963|Halobacteria	183963|Halobacteria	I	COG0183 Acetyl-CoA acetyltransferase	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
MMS3_k127_1638530_10	751944.HALDL1_10370	9.491e-33	147.0	COG1545@1|root,arCOG01285@2157|Archaea,2XXD4@28890|Euryarchaeota,23VSD@183963|Halobacteria	183963|Halobacteria	V	nucleic-acid-binding protein containing a Zn-ribbon	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
MMS3_k127_1638530_0	673860.AciM339_0753	1.582e-170	602.0	COG1287@1|root,arCOG02044@2157|Archaea,arCOG05365@2157|Archaea,2Y7QJ@28890|Euryarchaeota,3F2NE@33867|unclassified Euryarchaeota	28890|Euryarchaeota	I	Carboxypeptidase regulatory-like domain	-	-	2.4.99.18	ko:K07151	ko00510,ko00513,ko01100,ko04141,map00510,map00513,map01100,map04141	M00072	R04216,R05976	RC00005,RC00482	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT66	-	CarboxypepD_reg,PMT_2,STT3
MMS3_k127_1638530_13	273116.14325472	1.414e-07	62.0	arCOG05366@1|root,arCOG05366@2157|Archaea,2Y11W@28890|Euryarchaeota,241WB@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	CARDB
MMS3_k127_1638530_12	1132509.C447_08533	4.556e-13	71.0	COG2888@1|root,arCOG01989@2157|Archaea	2157|Archaea	J	Zn-ribbon RNA-binding protein with a function in translation	-	-	-	ko:K07580	-	-	-	-	ko00000	-	-	-	DUF1610
MMS3_k127_1638530_11	1041930.Mtc_2492	2.27e-16	81.0	COG2092@1|root,arCOG01988@2157|Archaea,2XYNW@28890|Euryarchaeota,2NA09@224756|Methanomicrobia	224756|Methanomicrobia	J	Promotes the exchange of GDP for GTP in EF-1-alpha GDP, thus allowing the regeneration of EF-1-alpha GTP that could then be used to form the ternary complex EF-1-alpha GTP AAtRNA	ef1b	-	-	ko:K03232	-	-	-	-	ko00000,ko03012	-	-	-	EF1_GNE
MMS3_k127_1638530_14	1345697.M493_02695	1.085e-05	57.0	COG1988@1|root,COG1988@2|Bacteria,1TQFC@1239|Firmicutes,4H9PU@91061|Bacilli,1WED8@129337|Geobacillus	91061|Bacilli	S	LexA-binding, inner membrane-associated putative hydrolase	yfhP	-	-	ko:K07038	-	-	-	-	ko00000	-	-	-	YdjM
MMS3_k127_1651698_4	273116.14324853	6.149e-06	59.0	arCOG15086@1|root,arCOG15086@2157|Archaea,2Y5IR@28890|Euryarchaeota,242F8@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_1651698_2	886379.AEWI01000013_gene2213	9.988e-08	65.0	COG2373@1|root,COG4386@1|root,COG2373@2|Bacteria,COG4386@2|Bacteria,4PP8A@976|Bacteroidetes	976|Bacteroidetes	S	Immunoglobulin	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_1651698_0	272557.APE_2196	4.725e-42	166.0	COG0513@1|root,arCOG00078@2157|Archaea,2XPRR@28889|Crenarchaeota	28889|Crenarchaeota	J	Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA	flpA	GO:0000154,GO:0000494,GO:0001510,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0006139,GO:0006325,GO:0006364,GO:0006396,GO:0006464,GO:0006479,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008213,GO:0008276,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0016074,GO:0016569,GO:0016570,GO:0016571,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0022613,GO:0031123,GO:0031126,GO:0031167,GO:0032259,GO:0033967,GO:0034470,GO:0034641,GO:0034660,GO:0034963,GO:0036009,GO:0036211,GO:0042054,GO:0042254,GO:0043144,GO:0043170,GO:0043412,GO:0043414,GO:0043628,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046483,GO:0051276,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140096,GO:0140098,GO:0140102,GO:1901360,GO:1901363,GO:1901564,GO:1990258,GO:1990259	-	ko:K04795	-	-	-	-	ko00000,ko03009	-	-	-	Fibrillarin
MMS3_k127_1651698_1	754252.PFREUD_19430	6.907e-27	119.0	COG0251@1|root,COG0251@2|Bacteria,2IHNE@201174|Actinobacteria,4DQIS@85009|Propionibacteriales	201174|Actinobacteria	J	YjgF/chorismate_mutase-like, putative endoribonuclease	yabJ	-	-	-	-	-	-	-	-	-	-	-	YjgF_endoribonc
MMS3_k127_1661833_0	1047013.AQSP01000122_gene2224	1.484e-61	241.0	COG3291@1|root,COG5434@1|root,COG3291@2|Bacteria,COG5434@2|Bacteria,2NQ6Y@2323|unclassified Bacteria	2|Bacteria	M	PKD domain	-	-	3.2.1.157,3.2.1.91	ko:K19668,ko:K20850	ko00500,ko01100,ko02020,map00500,map01100,map02020	-	R02886,R11308	RC00799	ko00000,ko00001,ko01000	-	GH6,GH82	-	Beta_helix,CHU_C,Cadherin-like,FlgD_ig,PKD,Pectate_lyase_3
MMS3_k127_1666356_3	1068980.ARVW01000001_gene3025	1.749e-09	66.0	COG2119@1|root,COG2119@2|Bacteria,2GNR0@201174|Actinobacteria,4E2WC@85010|Pseudonocardiales	201174|Actinobacteria	S	Uncharacterized protein family UPF0016	-	-	-	-	-	-	-	-	-	-	-	-	UPF0016
MMS3_k127_1666356_1	1054217.TALC_01158	4.299e-47	173.0	COG1781@1|root,arCOG04229@2157|Archaea,2XWP4@28890|Euryarchaeota,241SX@183967|Thermoplasmata	183967|Thermoplasmata	F	Involved in allosteric regulation of aspartate carbamoyltransferase	pyrI	-	-	ko:K00610	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002	-	-	-	PyrI,PyrI_C
MMS3_k127_1666356_0	439481.Aboo_1121	2.003e-108	361.0	COG0540@1|root,arCOG00911@2157|Archaea,2XSZ7@28890|Euryarchaeota,3F2F5@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	PFAM aspartate ornithine carbamoyltransferase carbamoyl-P binding domain	pyrB	GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A1168	OTCace,OTCace_N
MMS3_k127_1666356_2	977880.RALTA_A0036	2.94e-23	111.0	COG0697@1|root,COG0697@2|Bacteria,1MY0D@1224|Proteobacteria,2VKMI@28216|Betaproteobacteria	28216|Betaproteobacteria	EG	permeases of the drug metabolite transporter (Dmt) superfamily	-	-	-	ko:K15269	-	-	-	-	ko00000,ko02000	2.A.7.3.3	-	-	EamA
MMS3_k127_1671963_0	439481.Aboo_1131	2.788e-230	725.0	COG0459@1|root,arCOG01257@2157|Archaea,2XUDQ@28890|Euryarchaeota,3F2FS@33867|unclassified Euryarchaeota	28890|Euryarchaeota	O	TCP-1/cpn60 chaperonin family	thsA	GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0044183,GO:0051082,GO:0061077	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
MMS3_k127_1671963_3	1408813.AYMG01000014_gene1651	6.324e-28	132.0	COG1361@1|root,COG3291@1|root,COG4625@1|root,COG1361@2|Bacteria,COG3291@2|Bacteria,COG4625@2|Bacteria,4NDZC@976|Bacteroidetes,1IRJP@117747|Sphingobacteriia	976|Bacteroidetes	M	C-terminal domain of CHU protein family	-	-	-	ko:K21449	-	-	-	-	ko00000,ko02000	1.B.40.2	-	-	CHU_C,DUF11,He_PIG,fn3
MMS3_k127_1671963_1	186497.PF0249	1.6e-37	151.0	COG0127@1|root,arCOG04184@2157|Archaea,2XTS4@28890|Euryarchaeota,243RS@183968|Thermococci	183968|Thermococci	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	-	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
MMS3_k127_1671963_2	865861.AZSU01000001_gene485	2.014e-32	132.0	COG0778@1|root,COG0778@2|Bacteria,1UZUV@1239|Firmicutes,24F6B@186801|Clostridia,36IIV@31979|Clostridiaceae	186801|Clostridia	C	PFAM Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase,TM1586_NiRdase
MMS3_k127_1674044_8	279238.Saro_0200	3.354e-22	97.0	COG2151@1|root,COG2151@2|Bacteria,1MZ9Y@1224|Proteobacteria,2U72U@28211|Alphaproteobacteria,2K4IC@204457|Sphingomonadales	204457|Sphingomonadales	S	FeS assembly SUF system protein	-	-	-	-	-	-	-	-	-	-	-	-	FeS_assembly_P
MMS3_k127_1674044_9	673862.BABL1_707	4.414e-18	100.0	COG1520@1|root,COG2706@1|root,COG1520@2|Bacteria,COG2706@2|Bacteria,1QV8R@1224|Proteobacteria	1224|Proteobacteria	G	6-phosphogluconolactonase activity	-	-	-	ko:K20952	ko05111,map05111	-	-	-	ko00000,ko00001	-	-	-	Beta-prism_lec,DUF4347,HYR,VCBS
MMS3_k127_1674044_10	930945.SiRe_2604	0.0006009	53.0	arCOG03671@1|root,arCOG03671@2157|Archaea	2157|Archaea	S	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	Thermopsin
MMS3_k127_1674044_4	673860.AciM339_1463	1.446e-60	218.0	COG0013@1|root,arCOG01254@2157|Archaea,2XTZC@28890|Euryarchaeota,3F36Z@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Threonyl and Alanyl tRNA synthetase second additional domain	alaXM	GO:0002161,GO:0003674,GO:0003824,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360	6.1.1.7	ko:K01872,ko:K07050	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF692.Mbar_A2092	DHHA1,tRNA-synt_2c,tRNA_SAD
MMS3_k127_1674044_2	985053.VMUT_1160	2.919e-70	263.0	COG2421@1|root,arCOG01004@2157|Archaea,2XQIP@28889|Crenarchaeota	28889|Crenarchaeota	C	Acetamidase/Formamidase family	-	-	3.5.1.4,3.5.1.49	ko:K01426,ko:K01455	ko00330,ko00360,ko00380,ko00460,ko00627,ko00630,ko00643,ko00910,ko01120,ko01200,map00330,map00360,map00380,map00460,map00627,map00630,map00643,map00910,map01120,map01200	-	R00524,R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025,RC02432,RC02810	ko00000,ko00001,ko01000	-	-	-	FmdA_AmdA
MMS3_k127_1674044_6	358396.C445_05123	4.01e-38	151.0	COG3358@1|root,arCOG04570@2157|Archaea,2XX3J@28890|Euryarchaeota,23VM5@183963|Halobacteria	183963|Halobacteria	S	Protein of unknown function (DUF1684)	-	-	-	ko:K09164	-	-	-	-	ko00000	-	-	-	DUF1684
MMS3_k127_1674044_7	1254432.SCE1572_04905	4.152e-36	145.0	COG2095@1|root,COG2095@2|Bacteria,1MX5T@1224|Proteobacteria,42TIP@68525|delta/epsilon subdivisions,2WQA8@28221|Deltaproteobacteria,2YZB0@29|Myxococcales	28221|Deltaproteobacteria	U	UPF0056 inner membrane protein	marC	-	-	ko:K05595	-	-	-	-	ko00000,ko02000	2.A.95.1	-	-	MarC
MMS3_k127_1674044_0	869210.Marky_1642	8.567e-170	546.0	COG3033@1|root,COG3033@2|Bacteria,1WM62@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	PFAM aromatic amino acid beta-eliminating lyase threonine aldolase	tnaA	-	4.1.99.1	ko:K01667	ko00380,map00380	-	R00673	RC00209,RC00355	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
MMS3_k127_1674044_5	266117.Rxyl_0142	3.815e-39	150.0	COG1764@1|root,COG1764@2|Bacteria,2IFFB@201174|Actinobacteria,4CQIW@84995|Rubrobacteria	84995|Rubrobacteria	O	OsmC-like protein	-	-	-	ko:K04063	-	-	-	-	ko00000	-	-	-	OsmC
MMS3_k127_1674044_1	1121920.AUAU01000012_gene2703	1.565e-79	273.0	COG2102@1|root,COG2102@2|Bacteria,3Y46Z@57723|Acidobacteria	57723|Acidobacteria	S	Diphthamide synthase	-	-	-	-	-	-	-	-	-	-	-	-	Diphthami_syn_2
MMS3_k127_1674044_3	304371.MCP_1660	2.855e-61	224.0	COG0265@1|root,arCOG02833@2157|Archaea,2XT7Y@28890|Euryarchaeota,2NAWS@224756|Methanomicrobia	224756|Methanomicrobia	O	Trypsin	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
MMS3_k127_1684081_2	296591.Bpro_2831	2.109e-21	96.0	COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,2VHAC@28216|Betaproteobacteria,4ACX8@80864|Comamonadaceae	28216|Betaproteobacteria	E	Cys/Met metabolism PLP-dependent enzyme	-	-	2.5.1.48,4.4.1.1,4.4.1.11,4.4.1.8	ko:K01739,ko:K01758,ko:K01760,ko:K01761	ko00260,ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00260,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017,M00338	R00654,R00782,R00999,R01001,R01286,R01288,R02408,R02508,R03217,R03260,R04770,R04930,R04941,R04944,R04945,R04946,R09366	RC00020,RC00056,RC00069,RC00196,RC00348,RC00382,RC00420,RC00488,RC00710,RC01209,RC01210,RC01245,RC02303,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Cys_Met_Meta_PP
MMS3_k127_1684081_0	1128421.JAGA01000004_gene2611	1.637e-122	408.0	COG0031@1|root,COG0031@2|Bacteria,2NP1M@2323|unclassified Bacteria	2|Bacteria	E	Pyridoxal-phosphate dependent enzyme	cysK	-	2.5.1.47,4.2.1.22	ko:K01697,ko:K01738	ko00260,ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021,M00035,M00338	R00891,R00897,R01290,R03601,R04859,R04942	RC00020,RC00056,RC00069,RC00256,RC00489,RC01246,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	CBS,PALP
MMS3_k127_1684081_4	589924.Ferp_2084	7.344e-06	53.0	COG2461@1|root,COG3682@1|root,arCOG01472@2157|Archaea,arCOG05764@2157|Archaea	2157|Archaea	K	Transcriptional regulator	-	-	-	ko:K09155	-	-	-	-	ko00000	-	-	-	DUF438,Hemerythrin,PAS_10,Penicillinase_R
MMS3_k127_1684081_3	694430.Natoc_0703	9.633e-07	60.0	COG0281@1|root,arCOG01331@2157|Archaea,2XVAC@28890|Euryarchaeota,23UW4@183963|Halobacteria	183963|Halobacteria	O	Zn-dependent protease with chaperone function	-	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
MMS3_k127_1684081_5	439481.Aboo_1072	0.0002654	51.0	COG1361@1|root,arCOG02079@2157|Archaea,2Y6ZQ@28890|Euryarchaeota,3F30V@33867|unclassified Euryarchaeota	28890|Euryarchaeota	M	COG1361 S-layer domain	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_1684081_1	1041930.Mtc_1643	6.672e-45	174.0	COG0644@1|root,arCOG00570@2157|Archaea,2XUI9@28890|Euryarchaeota,2N9DD@224756|Methanomicrobia	224756|Methanomicrobia	C	TIGRFAM geranylgeranyl reductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3,HI0933_like,Lycopene_cycl
MMS3_k127_1730587_4	1408452.JAGZ01000020_gene58	1.722e-11	76.0	COG0500@1|root,COG2226@2|Bacteria,2IHXS@201174|Actinobacteria,239GN@1762|Mycobacteriaceae	201174|Actinobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
MMS3_k127_1730587_0	42099.EPrPV00000017260	5.835e-129	421.0	COG1052@1|root,KOG0069@2759|Eukaryota	2759|Eukaryota	CH	hydroxypyruvate reductase activity	FDH1	GO:0003674,GO:0003824,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005829,GO:0006082,GO:0006083,GO:0008150,GO:0008152,GO:0008863,GO:0009056,GO:0009507,GO:0009536,GO:0009579,GO:0009987,GO:0010035,GO:0010038,GO:0015942,GO:0016054,GO:0016491,GO:0016620,GO:0016903,GO:0016999,GO:0017001,GO:0017144,GO:0019752,GO:0032787,GO:0042183,GO:0042221,GO:0042737,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0046686,GO:0050896,GO:0055114,GO:0071704,GO:0072329,GO:1901575	1.17.1.9	ko:K00122	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	iMM904.YOR388C,iND750.YOR388C	2-Hacid_dh,2-Hacid_dh_C
MMS3_k127_1730587_5	673860.AciM339_0922	2.064e-09	64.0	COG1321@1|root,arCOG02100@2157|Archaea,2Y75S@28890|Euryarchaeota,3F3FT@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	PFAM iron dependent repressor	-	-	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,Fe_dep_repress
MMS3_k127_1730587_1	572478.Vdis_1512	5.476e-95	324.0	arCOG06008@1|root,arCOG06008@2157|Archaea,2XRQ9@28889|Crenarchaeota	28889|Crenarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_1730587_2	717606.PaecuDRAFT_4483	3.874e-70	250.0	COG1089@1|root,COG1089@2|Bacteria,1UJFF@1239|Firmicutes,4HF5Y@91061|Bacilli,275YJ@186822|Paenibacillaceae	91061|Bacilli	M	Polysaccharide biosynthesis protein	-	-	1.1.1.281	ko:K15856	ko00051,ko00520,map00051,map00520	-	R03397,R03399	RC00182	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
MMS3_k127_1730587_3	1047013.AQSP01000122_gene2224	7.188e-21	109.0	COG3291@1|root,COG5434@1|root,COG3291@2|Bacteria,COG5434@2|Bacteria,2NQ6Y@2323|unclassified Bacteria	2|Bacteria	M	PKD domain	-	-	3.2.1.157,3.2.1.91	ko:K19668,ko:K20850	ko00500,ko01100,ko02020,map00500,map01100,map02020	-	R02886,R11308	RC00799	ko00000,ko00001,ko01000	-	GH6,GH82	-	Beta_helix,CHU_C,Cadherin-like,FlgD_ig,PKD,Pectate_lyase_3
MMS3_k127_1730587_7	529818.AMSG_09085T0	0.0001095	56.0	KOG0379@1|root,KOG0379@2759|Eukaryota	2759|Eukaryota	P	nitrile biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	Kelch_3,Kelch_4,Kelch_6
MMS3_k127_1730587_6	374847.Kcr_0584	0.0001	52.0	COG1522@1|root,arCOG01580@2157|Archaea	2157|Archaea	K	COG1522 Transcriptional regulators	lrpA	-	-	ko:K03718	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
MMS3_k127_1731598_1	1158318.ATXC01000001_gene1138	1.527e-58	218.0	COG0215@1|root,COG0215@2|Bacteria,2G3JG@200783|Aquificae	200783|Aquificae	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e,tRNA-synt_1g
MMS3_k127_1731598_10	469371.Tbis_2790	2.708e-06	60.0	COG1522@1|root,COG1522@2|Bacteria,2IQ4Z@201174|Actinobacteria,4E5C4@85010|Pseudonocardiales	201174|Actinobacteria	K	AsnC family	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
MMS3_k127_1731598_5	502025.Hoch_1884	5.79e-35	138.0	COG1225@1|root,COG1225@2|Bacteria,1RD4R@1224|Proteobacteria,43APU@68525|delta/epsilon subdivisions,2X63M@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
MMS3_k127_1731598_3	1041930.Mtc_0311	1.086e-53	217.0	COG2409@1|root,arCOG02175@2157|Archaea,2XVKJ@28890|Euryarchaeota	28890|Euryarchaeota	S	MMPL family	-	-	-	ko:K06994	-	-	-	-	ko00000	-	-	-	MMPL
MMS3_k127_1731598_2	397948.Cmaq_0155	3.524e-57	218.0	COG0130@1|root,arCOG00987@2157|Archaea,2XPWX@28889|Crenarchaeota	28889|Crenarchaeota	J	Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs	truB	GO:0000154,GO:0000495,GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016072,GO:0016073,GO:0016074,GO:0016556,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0031120,GO:0031123,GO:0031126,GO:0033979,GO:0034470,GO:0034641,GO:0034660,GO:0034964,GO:0040031,GO:0042254,GO:0043144,GO:0043170,GO:0043412,GO:0043628,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360,GO:1990481	5.4.99.25	ko:K03177,ko:K11131	ko03008,map03008	M00425	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03016,ko03032	-	-	-	DKCLD,PUA,TruB_C_2,TruB_N
MMS3_k127_1731598_8	1236689.MMALV_14010	5.137e-22	113.0	COG0130@1|root,COG1102@1|root,arCOG00987@2157|Archaea,arCOG01037@2157|Archaea,2XTUE@28890|Euryarchaeota,3F354@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs	truB	GO:0000154,GO:0000495,GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016072,GO:0016073,GO:0016074,GO:0016556,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0031120,GO:0031123,GO:0031126,GO:0033979,GO:0034470,GO:0034641,GO:0034660,GO:0034964,GO:0040031,GO:0042254,GO:0043144,GO:0043170,GO:0043412,GO:0043628,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360,GO:1990481	5.4.99.25	ko:K03177,ko:K11131	ko03008,map03008	M00425	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03016,ko03032	-	-	-	DKCLD,PUA,TruB_C_2,TruB_N
MMS3_k127_1731598_9	673860.AciM339_1123	2.575e-12	76.0	COG1422@1|root,arCOG02673@2157|Archaea,2XZDK@28890|Euryarchaeota,3F2U5@33867|unclassified Euryarchaeota	28890|Euryarchaeota	U	Integral membrane protein DUF106	-	-	-	-	-	-	-	-	-	-	-	-	DUF106
MMS3_k127_1731598_0	673860.AciM339_1121	9.611e-219	693.0	COG5253@1|root,arCOG04169@2157|Archaea,2XT9A@28890|Euryarchaeota,3F2F6@33867|unclassified Euryarchaeota	28890|Euryarchaeota	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	Plug_translocon,SecY
MMS3_k127_1731598_7	1054217.TALC_01312	9.359e-25	110.0	COG0200@1|root,arCOG00779@2157|Archaea,2Y6A4@28890|Euryarchaeota,241UA@183967|Thermoplasmata	183967|Thermoplasmata	J	Binds to the 23S rRNA	rpl15	-	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
MMS3_k127_1731598_6	439481.Aboo_1500	6.773e-27	123.0	COG1841@1|root,arCOG04086@2157|Archaea,2XWGP@28890|Euryarchaeota,3F2NM@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Ribosomal protein L30p/L7e	rpl30	GO:0000463,GO:0000470,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
MMS3_k127_1731598_4	1236689.MMALV_14060	4.737e-53	193.0	COG0098@1|root,arCOG04087@2157|Archaea,2XUQU@28890|Euryarchaeota,3F2HF@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	With S4 and S12 plays an important role in translational accuracy	rps5	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
MMS3_k127_1742747_5	1144307.PMI04_01584	2.155e-20	104.0	COG0475@1|root,COG0475@2|Bacteria,1MVGV@1224|Proteobacteria,2TUCH@28211|Alphaproteobacteria,2K24B@204457|Sphingomonadales	204457|Sphingomonadales	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
MMS3_k127_1742747_8	1232436.CAPF01000005_gene1842	5.738e-11	73.0	COG0560@1|root,COG0560@2|Bacteria,2HVFQ@201174|Actinobacteria,4CWSR@84998|Coriobacteriia	84998|Coriobacteriia	E	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD
MMS3_k127_1742747_3	1054217.TALC_00178	5.865e-32	139.0	arCOG03678@1|root,arCOG03678@2157|Archaea,2XZ63@28890|Euryarchaeota,241VC@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_1742747_4	1236689.MMALV_07840	1.172e-29	126.0	COG1901@1|root,arCOG01239@2157|Archaea,2XTSB@28890|Euryarchaeota,3F2S0@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs	trmY	GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.257	ko:K16317	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltrn_RNA_2
MMS3_k127_1742747_1	1210908.HSB1_11980	4.338e-44	176.0	COG0206@1|root,arCOG02201@2157|Archaea,2XTMW@28890|Euryarchaeota,23SH5@183963|Halobacteria	183963|Halobacteria	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ1	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
MMS3_k127_1742747_6	673860.AciM339_0078	4.291e-14	76.0	COG3609@1|root,arCOG06966@2157|Archaea,2Y5GZ@28890|Euryarchaeota,3F3D2@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	Ribbon-helix-helix protein, copG family	-	-	-	ko:K07722	-	-	-	-	ko00000,ko03000	-	-	-	RHH_1
MMS3_k127_1742747_0	261292.Nit79A3_2506	6.171e-85	293.0	COG1940@1|root,COG1940@2|Bacteria,1NSQA@1224|Proteobacteria,2WC2A@28216|Betaproteobacteria,37479@32003|Nitrosomonadales	28216|Betaproteobacteria	GK	ROK family	-	-	2.7.1.63	ko:K00886	ko00010,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R02187,R02189	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
MMS3_k127_1742747_7	1031288.AXAA01000022_gene1581	2.257e-13	83.0	COG0477@1|root,COG2814@2|Bacteria,1UZPE@1239|Firmicutes,2490R@186801|Clostridia,36EGS@31979|Clostridiaceae	186801|Clostridia	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_2,MFS_3
MMS3_k127_1742747_2	1236689.MMALV_05030	2.725e-33	139.0	COG1537@1|root,arCOG01741@2157|Archaea,2XTQ4@28890|Euryarchaeota,3F2P2@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity	pelA	GO:0000956,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006402,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016043,GO:0016070,GO:0016071,GO:0016072,GO:0016075,GO:0019222,GO:0019439,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0034655,GO:0034660,GO:0034661,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044267,GO:0044270,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0070651,GO:0070966,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360,GO:1901361,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1903008	-	ko:K06965	ko03015,map03015	-	-	-	ko00000,ko00001	-	-	-	eRF1_1,eRF1_2,eRF1_3
MMS3_k127_1750988_18	1454007.JAUG01000025_gene976	6.842e-10	73.0	COG1361@1|root,COG3291@1|root,COG3420@1|root,COG4625@1|root,COG1361@2|Bacteria,COG3291@2|Bacteria,COG3420@2|Bacteria,COG4625@2|Bacteria,4NDZC@976|Bacteroidetes,1IRJP@117747|Sphingobacteriia	976|Bacteroidetes	M	C-terminal domain of CHU protein family	-	-	-	ko:K21449	-	-	-	-	ko00000,ko02000	1.B.40.2	-	-	CHU_C,DUF11,He_PIG,fn3
MMS3_k127_1750988_20	1144672.F966_02334	6.875e-05	55.0	COG0625@1|root,COG0625@2|Bacteria,1N4MK@1224|Proteobacteria,1SH5B@1236|Gammaproteobacteria,3NM84@468|Moraxellaceae	1236|Gammaproteobacteria	O	Glutathione S-transferase N-terminal domain	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C_3,GST_N_3
MMS3_k127_1750988_11	1470591.BW41_02375	5.227e-27	119.0	COG2151@1|root,COG2151@2|Bacteria,1MZ9Y@1224|Proteobacteria,2U72U@28211|Alphaproteobacteria,2K4IC@204457|Sphingomonadales	204457|Sphingomonadales	S	FeS assembly SUF system protein	-	-	-	-	-	-	-	-	-	-	-	-	FeS_assembly_P
MMS3_k127_1750988_4	1125863.JAFN01000001_gene1621	1.374e-92	315.0	COG1741@1|root,COG1741@2|Bacteria,1MWIP@1224|Proteobacteria,42N8V@68525|delta/epsilon subdivisions,2WJWB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
MMS3_k127_1750988_17	1121946.AUAX01000002_gene136	1.097e-10	74.0	arCOG11292@1|root,30GCQ@2|Bacteria,2IDTR@201174|Actinobacteria,4DDSP@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_1750988_13	399549.Msed_1003	9.24e-19	101.0	arCOG02703@1|root,arCOG02703@2157|Archaea,2XS5Q@28889|Crenarchaeota	28889|Crenarchaeota	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
MMS3_k127_1750988_8	1123405.AUMM01000004_gene643	1.594e-53	204.0	COG2084@1|root,COG2084@2|Bacteria,1UKMF@1239|Firmicutes,4HENU@91061|Bacilli,26P7X@186821|Sporolactobacillaceae	91061|Bacilli	I	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	-	-	1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
MMS3_k127_1750988_6	1242864.D187_001408	2.58e-70	255.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
MMS3_k127_1750988_1	937777.Deipe_2643	1.564e-123	410.0	COG0513@1|root,COG0513@2|Bacteria,1WKZ3@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	L	helicase superfamily c-terminal domain	-	-	3.6.4.13	ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DEAD,Helicase_C
MMS3_k127_1750988_14	1459636.NTE_00882	3.004e-17	89.0	COG0426@1|root,arCOG00509@2157|Archaea	2157|Archaea	C	flavodoxin nitric oxide synthase	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_1
MMS3_k127_1750988_3	525909.Afer_1537	1.554e-99	335.0	COG0115@1|root,COG0115@2|Bacteria,2GKJ1@201174|Actinobacteria,4CMVG@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
MMS3_k127_1750988_12	925775.XVE_4058	1.125e-24	111.0	COG2020@1|root,COG2020@2|Bacteria,1N936@1224|Proteobacteria,1SCXB@1236|Gammaproteobacteria,1X823@135614|Xanthomonadales	135614|Xanthomonadales	O	Methyltransferase	-	-	2.1.1.100	ko:K00587	ko00900,ko01130,map00900,map01130	-	R04496	RC00003,RC00460	ko00000,ko00001,ko01000	-	-	-	PEMT
MMS3_k127_1750988_7	309807.SRU_2382	9.767e-60	216.0	COG0384@1|root,COG0384@2|Bacteria,4NEWM@976|Bacteroidetes,1FJA8@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	Phenazine biosynthesis-like protein	-	-	-	-	-	-	-	-	-	-	-	-	PhzC-PhzF
MMS3_k127_1750988_10	399549.Msed_1238	4.891e-35	143.0	COG3374@1|root,arCOG04349@2157|Archaea	2157|Archaea	S	Protein of unknown function (DUF981)	-	-	-	ko:K08980	-	-	-	-	ko00000	-	-	-	DUF981
MMS3_k127_1750988_21	525904.Tter_2561	0.0001375	50.0	COG3462@1|root,COG3462@2|Bacteria	2|Bacteria	S	membrane protein (DUF2078)	-	-	-	ko:K08982	-	-	-	-	ko00000	-	-	-	SHOCT
MMS3_k127_1750988_16	349124.Hhal_2426	6.085e-13	81.0	COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,1RMVN@1236|Gammaproteobacteria,1WW41@135613|Chromatiales	135613|Chromatiales	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
MMS3_k127_1750988_0	292459.STH1872	2.376e-131	430.0	COG0156@1|root,COG0156@2|Bacteria,1TPUX@1239|Firmicutes,2491D@186801|Clostridia	186801|Clostridia	H	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide	kbl	GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008710,GO:0008890,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.3.1.29	ko:K00639	ko00260,map00260	-	R00371	RC00004,RC00394	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
MMS3_k127_1750988_2	1128421.JAGA01000002_gene163	8.482e-109	362.0	COG1063@1|root,COG1063@2|Bacteria,2NPK3@2323|unclassified Bacteria	2|Bacteria	E	Zinc-binding dehydrogenase	tdh	-	1.1.1.103	ko:K00060	ko00260,map00260	-	R01465	RC00525	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
MMS3_k127_1750988_5	697281.Mahau_2246	2.341e-72	264.0	COG0493@1|root,COG0493@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,42EUY@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	gltA	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	DHODB_Fe-S_bind,Fer4_20,Pyr_redox_2
MMS3_k127_1750988_9	1246474.ANBE01000038_gene4301	2.712e-36	156.0	COG1479@1|root,COG3472@1|root,COG1479@2|Bacteria,COG3472@2|Bacteria,2IF65@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function DUF262	-	-	-	-	-	-	-	-	-	-	-	-	DUF262
MMS3_k127_1750988_19	272943.RSP_3263	3.496e-06	57.0	COG4454@1|root,COG4454@2|Bacteria,1R91G@1224|Proteobacteria,2U6DH@28211|Alphaproteobacteria,1FCU8@1060|Rhodobacter	28211|Alphaproteobacteria	P	Copper binding proteins, plastocyanin/azurin family	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,CusF_Ec
MMS3_k127_1750988_15	1340493.JNIF01000003_gene4150	4.102e-14	88.0	COG1470@1|root,COG4625@1|root,COG1470@2|Bacteria,COG4625@2|Bacteria,3Y354@57723|Acidobacteria	57723|Acidobacteria	M	PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	He_PIG
MMS3_k127_1786724_14	694430.Natoc_1555	4.404e-09	60.0	COG0013@1|root,arCOG01254@2157|Archaea,2XTZC@28890|Euryarchaeota,23UTP@183963|Halobacteria	183963|Halobacteria	J	metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain	-	-	-	ko:K07050	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA-synt_2c,tRNA_SAD
MMS3_k127_1786724_10	103733.JNYO01000002_gene588	1.416e-18	94.0	COG1670@1|root,COG1670@2|Bacteria,2IIWF@201174|Actinobacteria,4E41X@85010|Pseudonocardiales	201174|Actinobacteria	J	Acetyltransferase (GNAT) domain	-	-	2.3.1.128	ko:K03790	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1,Acetyltransf_3
MMS3_k127_1786724_12	273075.Ta0177	5.711e-14	74.0	arCOG05238@1|root,arCOG05238@2157|Archaea,2Y0YG@28890|Euryarchaeota,242C6@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_1786724_1	1041930.Mtc_1753	3.393e-92	314.0	COG0451@1|root,arCOG01369@2157|Archaea,2XTRS@28890|Euryarchaeota,2N966@224756|Methanomicrobia	224756|Methanomicrobia	M	PFAM NAD-dependent epimerase dehydratase	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
MMS3_k127_1786724_11	1463855.JOHV01000041_gene4699	1.343e-15	88.0	COG1216@1|root,COG1216@2|Bacteria,2GKTW@201174|Actinobacteria	201174|Actinobacteria	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glyco_trans_2_3,Glycos_transf_2
MMS3_k127_1786724_8	877455.Metbo_0375	3.587e-21	104.0	COG1047@1|root,arCOG00980@2157|Archaea,2XTB7@28890|Euryarchaeota,23NZB@183925|Methanobacteria	183925|Methanobacteria	O	Peptidyl-prolyl cis-trans isomerase	-	-	5.2.1.8	ko:K01802,ko:K03775	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C
MMS3_k127_1786724_7	404589.Anae109_1609	6.502e-27	119.0	COG0116@1|root,COG0116@2|Bacteria	2|Bacteria	L	23S rRNA (guanine(2445)-N(2))-methyltransferase activity	-	-	2.1.1.209	ko:K21515	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_31,UPF0020
MMS3_k127_1786724_2	1121472.AQWN01000003_gene1518	3.34e-78	281.0	COG1703@1|root,COG1703@2|Bacteria,1TQT4@1239|Firmicutes,24944@186801|Clostridia,26211@186807|Peptococcaceae	186801|Clostridia	E	ArgK protein	-	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK
MMS3_k127_1786724_4	484019.THA_1415	1.479e-49	180.0	COG2185@1|root,COG2185@2|Bacteria,2GD2V@200918|Thermotogae	200918|Thermotogae	I	PFAM cobalamin B12-binding domain protein	-	-	5.4.99.2	ko:K01849	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding
MMS3_k127_1786724_15	572546.Arcpr_0277	4.568e-09	68.0	COG1989@1|root,arCOG02298@2157|Archaea,2XUQP@28890|Euryarchaeota,24693@183980|Archaeoglobi	183980|Archaeoglobi	N	Peptidase A24B, FlaK domain protein	-	-	3.4.23.52	ko:K07991	-	-	-	-	ko00000,ko01000,ko01002,ko02035,ko02044	-	-	-	Arc_PepC_II,Peptidase_A24
MMS3_k127_1786724_6	386456.JQKN01000001_gene1812	1.433e-28	120.0	COG2125@1|root,arCOG01946@2157|Archaea,2XXZJ@28890|Euryarchaeota,23P5A@183925|Methanobacteria	183925|Methanobacteria	J	Belongs to the eukaryotic ribosomal protein eS6 family	rps6e	-	-	ko:K02991	ko01521,ko03010,ko04066,ko04150,ko04151,ko04371,ko04714,ko04910,ko05205,map01521,map03010,map04066,map04150,map04151,map04371,map04714,map04910,map05205	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S6e
MMS3_k127_1786724_0	1054217.TALC_00119	6.128e-154	503.0	COG3276@1|root,arCOG01563@2157|Archaea,2XUKU@28890|Euryarchaeota,241M1@183967|Thermoplasmata	183967|Thermoplasmata	J	eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA	eif2g	-	-	ko:K03242	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	GTP_EFTU,eIF2_C
MMS3_k127_1786724_9	1041930.Mtc_2324	1.348e-19	89.0	COG2835@1|root,arCOG04124@2157|Archaea,2XZRS@28890|Euryarchaeota,2NA4S@224756|Methanomicrobia	224756|Methanomicrobia	S	Trm112p-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Trm112p
MMS3_k127_1786724_13	266835.14024904	1.865e-10	73.0	COG4280@1|root,COG4280@2|Bacteria,1R6ER@1224|Proteobacteria,2U4XX@28211|Alphaproteobacteria,43NH3@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Uncharacterized protein family UPF0016	-	-	-	-	-	-	-	-	-	-	-	-	OFeT_1,UPF0016
MMS3_k127_1786724_5	439481.Aboo_0002	1.564e-29	136.0	COG0681@1|root,arCOG01739@2157|Archaea,2Y6XH@28890|Euryarchaeota,3F2QN@33867|unclassified Euryarchaeota	28890|Euryarchaeota	U	Signal peptidase	-	-	3.4.21.89	ko:K13280	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	-
MMS3_k127_1786724_16	797114.C475_14443	0.0006055	49.0	arCOG02416@1|root,arCOG02416@2157|Archaea,2Y01H@28890|Euryarchaeota,23XTV@183963|Halobacteria	183963|Halobacteria	N	protein conserved in archaea	pilA2	-	-	-	-	-	-	-	-	-	-	-	Pilin_N
MMS3_k127_1786724_3	666510.ASAC_0901	9.228e-74	261.0	arCOG00144@1|root,arCOG00144@2157|Archaea,2XQ4R@28889|Crenarchaeota	28889|Crenarchaeota	G	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS3_k127_1850352_0	1149133.ppKF707_6085	1.123e-69	245.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RMMJ@1236|Gammaproteobacteria,1YFI4@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
MMS3_k127_1850352_1	1227487.C474_01507	4.608e-61	238.0	COG1293@1|root,arCOG01695@2157|Archaea,2XTMF@28890|Euryarchaeota,23S1R@183963|Halobacteria	183963|Halobacteria	K	RNA-binding protein homologous to eukaryotic snRNP	-	-	-	-	-	-	-	-	-	-	-	-	DUF814,FbpA
MMS3_k127_1862954_6	1163617.SCD_n00469	6.125e-06	58.0	COG0025@1|root,COG0569@1|root,COG0025@2|Bacteria,COG0569@2|Bacteria,1QTUE@1224|Proteobacteria,2WHHS@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger,TrkA_N
MMS3_k127_1862954_3	269797.Mbar_A0608	5.957e-29	130.0	COG0535@1|root,arCOG00938@2157|Archaea,2XZ9M@28890|Euryarchaeota,2NANF@224756|Methanomicrobia	224756|Methanomicrobia	S	Radical SAM superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DUF3463,Radical_SAM
MMS3_k127_1862954_1	391623.TERMP_00885	1.568e-46	179.0	COG0463@1|root,arCOG00895@2157|Archaea,2Y66T@28890|Euryarchaeota,2454F@183968|Thermococci	183968|Thermococci	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
MMS3_k127_1862954_0	592015.HMPREF1705_00545	5.725e-108	360.0	COG2605@1|root,COG2605@2|Bacteria,3TC8T@508458|Synergistetes	508458|Synergistetes	S	GHMP kinases C terminal	-	-	2.7.1.168	ko:K07031	ko00540,map00540	-	R09770	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
MMS3_k127_1862954_2	673860.AciM339_1397	1.966e-31	129.0	COG1051@1|root,COG2005@1|root,arCOG00223@2157|Archaea,arCOG01075@2157|Archaea,2XXS4@28890|Euryarchaeota,3F39U@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
MMS3_k127_1862954_4	178306.PAE2889	2.459e-21	102.0	COG3371@1|root,arCOG02008@2157|Archaea	2157|Archaea	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF998
MMS3_k127_1862954_5	446471.Xcel_1604	3.138e-07	62.0	COG0500@1|root,COG2226@2|Bacteria,2IA9Q@201174|Actinobacteria	201174|Actinobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
MMS3_k127_1868771_2	523850.TON_0673	9.746e-05	55.0	COG2520@1|root,arCOG00033@2157|Archaea,2XTSI@28890|Euryarchaeota,242WN@183968|Thermococci	183968|Thermococci	J	Met-10+ like-protein	-	GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.228	ko:K15429	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	Met_10
MMS3_k127_1868771_0	368408.Tpen_1046	1.312e-86	302.0	COG3635@1|root,arCOG01696@2157|Archaea,2XPTU@28889|Crenarchaeota	28889|Crenarchaeota	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	apgM	-	5.4.2.12	ko:K15635	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,PhosphMutase
MMS3_k127_1868771_3	673860.AciM339_0995	0.0001116	55.0	COG1572@1|root,COG2304@1|root,arCOG02420@1|root,arCOG07560@1|root,arCOG02420@2157|Archaea,arCOG02532@2157|Archaea,arCOG02900@2157|Archaea,arCOG07560@2157|Archaea	2157|Archaea	Q	Archaeal Type IV pilin, N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_5,CARDB,CarboxypepD_reg,DUF3344,PKD,Pilin_N,VWA_2
MMS3_k127_1868771_1	1077974.GOEFS_081_00200	1.515e-10	71.0	COG0206@1|root,COG0206@2|Bacteria,2GJWC@201174|Actinobacteria,4GCBJ@85026|Gordoniaceae	201174|Actinobacteria	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	GO:0000166,GO:0000287,GO:0000910,GO:0000921,GO:0000935,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006996,GO:0007010,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0022402,GO:0022607,GO:0030428,GO:0031106,GO:0032153,GO:0032155,GO:0032185,GO:0032506,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034622,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043933,GO:0044085,GO:0044424,GO:0044464,GO:0045787,GO:0046872,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051258,GO:0051301,GO:0051726,GO:0065003,GO:0065007,GO:0070925,GO:0071840,GO:0071944,GO:0090529,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
MMS3_k127_1869220_0	871968.DESME_06265	1e-132	435.0	COG0499@1|root,COG0499@2|Bacteria,1TQY0@1239|Firmicutes,248S3@186801|Clostridia,2604M@186807|Peptococcaceae	186801|Clostridia	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
MMS3_k127_1869220_2	498848.TaqDRAFT_4455	2.592e-39	150.0	COG0509@1|root,COG0509@2|Bacteria,1WJYK@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
MMS3_k127_1869220_1	399549.Msed_2001	3.263e-59	218.0	COG1250@1|root,arCOG00249@2157|Archaea,2XPQ7@28889|Crenarchaeota	28889|Crenarchaeota	I	3-hydroxyacyl-CoA dehydrogenase	-	GO:0003674,GO:0003824,GO:0016829,GO:0016835,GO:0016836,GO:0043956	1.1.1.157,1.1.1.35,4.2.1.116,4.2.1.17	ko:K00074,ko:K15016,ko:K15019	ko00360,ko00362,ko00650,ko00720,ko01100,ko01120,ko01200,map00360,map00362,map00650,map00720,map01100,map01120,map01200	M00374,M00375	R01975,R01976,R03026,R03045,R05576,R06941	RC00029,RC00117,RC00831,RC00834	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
MMS3_k127_1871653_19	309801.trd_0889	5.258e-05	49.0	COG0665@1|root,COG0665@2|Bacteria,2G6HT@200795|Chloroflexi,27YWR@189775|Thermomicrobia	189775|Thermomicrobia	E	NAD(P)-binding Rossmann-like domain	-	-	1.5.3.1	ko:K00303	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO
MMS3_k127_1871653_6	673860.AciM339_0375	5.083e-72	253.0	COG0582@1|root,arCOG01241@2157|Archaea,2XV3E@28890|Euryarchaeota,3F2X0@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules	xerA	-	-	ko:K03733,ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_int_SAM_4,Phage_integrase
MMS3_k127_1871653_7	273075.Ta1119	1.575e-67	241.0	COG0037@1|root,arCOG00042@2157|Archaea,2XTEZ@28890|Euryarchaeota,241N6@183967|Thermoplasmata	183967|Thermoplasmata	D	PP-loop family	-	-	-	-	-	-	-	-	-	-	-	-	ATP_bind_3
MMS3_k127_1871653_5	159450.NH14_21165	1.002e-72	265.0	COG1250@1|root,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2VGZU@28216|Betaproteobacteria,1K0VY@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Dehydrogenase	paaH1	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
MMS3_k127_1871653_11	439481.Aboo_0448	4.194e-38	154.0	COG2339@1|root,arCOG02985@2157|Archaea	2157|Archaea	S	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	PrsW-protease
MMS3_k127_1871653_14	439481.Aboo_0398	3.629e-22	100.0	arCOG03678@1|root,arCOG03678@2157|Archaea,2XZ63@28890|Euryarchaeota,3F2RS@33867|unclassified Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_1871653_4	593750.Metfor_1111	9.273e-85	297.0	COG1258@1|root,arCOG01015@2157|Archaea,2XTTX@28890|Euryarchaeota,2N98Y@224756|Methanomicrobia	224756|Methanomicrobia	J	Responsible for synthesis of pseudouridine from uracil- 54 and uracil-55 in the psi GC loop of transfer RNAs	pus10	-	5.4.99.25	ko:K07583	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	THUMP
MMS3_k127_1871653_13	1343739.PAP_03525	3.598e-23	102.0	COG2139@1|root,arCOG04129@2157|Archaea,2XXZB@28890|Euryarchaeota,244BJ@183968|Thermococci	183968|Thermococci	J	Belongs to the eukaryotic ribosomal protein eL21 family	rpl21e	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02889	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21e
MMS3_k127_1871653_15	673860.AciM339_0302	8.261e-21	96.0	COG1460@1|root,arCOG01016@2157|Archaea,2Y6FQ@28890|Euryarchaeota,3F2SK@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	RNA polymerase	-	-	2.7.7.6	ko:K03051	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb4
MMS3_k127_1871653_9	273075.Ta1299	4.377e-48	180.0	COG1491@1|root,arCOG04130@2157|Archaea,2XXAI@28890|Euryarchaeota,241Q5@183967|Thermoplasmata	183967|Thermoplasmata	J	Protein of unknown function (DUF655)	-	-	-	ko:K07572	-	-	-	-	ko00000	-	-	-	DUF655
MMS3_k127_1871653_12	644966.Tmar_0085	2.829e-36	149.0	COG0030@1|root,COG0030@2|Bacteria,1TP9W@1239|Firmicutes,248RY@186801|Clostridia,3WCJ0@538999|Clostridiales incertae sedis	186801|Clostridia	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
MMS3_k127_1871653_2	1304872.JAGC01000003_gene3445	1.814e-109	374.0	COG0798@1|root,COG0798@2|Bacteria,1MUXY@1224|Proteobacteria,42M0Z@68525|delta/epsilon subdivisions,2WK36@28221|Deltaproteobacteria,2M8NG@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	PFAM Bile acid sodium symporter	arsB	-	-	ko:K03325	-	-	-	-	ko00000,ko02000	2.A.59	-	-	SBF
MMS3_k127_1871653_16	552811.Dehly_1324	3.958e-18	96.0	COG0394@1|root,COG0394@2|Bacteria,2G6TY@200795|Chloroflexi,34DCS@301297|Dehalococcoidia	301297|Dehalococcoidia	T	Low molecular weight phosphatase family	arsC	-	1.20.4.1	ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
MMS3_k127_1871653_17	996637.SGM_4099	1.871e-14	77.0	COG1733@1|root,COG1733@2|Bacteria,2IQNN@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
MMS3_k127_1871653_0	673860.AciM339_1242	5.264e-205	650.0	COG0459@1|root,arCOG01257@2157|Archaea,2XUDQ@28890|Euryarchaeota,3F2WH@33867|unclassified Euryarchaeota	28890|Euryarchaeota	O	TCP-1/cpn60 chaperonin family	thsA	GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0044183,GO:0051082,GO:0061077	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
MMS3_k127_1871653_10	671065.MetMK1DRAFT_00026550	1.407e-38	151.0	COG0454@1|root,arCOG00831@2157|Archaea,2XSA6@28889|Crenarchaeota	28889|Crenarchaeota	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_1871653_1	869210.Marky_1108	1.569e-120	404.0	COG1190@1|root,COG1190@2|Bacteria,1WI4Z@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
MMS3_k127_1871653_18	439481.Aboo_0583	5.311e-12	74.0	COG3398@1|root,arCOG02611@2157|Archaea,2XWAQ@28890|Euryarchaeota,3F3BI@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_24,HTH_5
MMS3_k127_1871653_8	1042877.GQS_09445	1.209e-61	222.0	COG1131@1|root,arCOG00194@2157|Archaea,2XT7Q@28890|Euryarchaeota,243M3@183968|Thermococci	183968|Thermococci	E	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
MMS3_k127_1871653_3	667632.KB890164_gene2043	1.004e-92	316.0	COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,2VH5Z@28216|Betaproteobacteria,1K21B@119060|Burkholderiaceae	28216|Betaproteobacteria	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
MMS3_k127_1933916_3	694429.Pyrfu_0791	1.314e-37	162.0	COG0513@1|root,arCOG00078@2157|Archaea,2XPRR@28889|Crenarchaeota	28889|Crenarchaeota	J	Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA	flpA	GO:0000154,GO:0000494,GO:0001510,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0006139,GO:0006325,GO:0006364,GO:0006396,GO:0006464,GO:0006479,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008213,GO:0008276,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0016074,GO:0016569,GO:0016570,GO:0016571,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0022613,GO:0031123,GO:0031126,GO:0031167,GO:0032259,GO:0033967,GO:0034470,GO:0034641,GO:0034660,GO:0034963,GO:0036009,GO:0036211,GO:0042054,GO:0042254,GO:0043144,GO:0043170,GO:0043412,GO:0043414,GO:0043628,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046483,GO:0051276,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140096,GO:0140098,GO:0140102,GO:1901360,GO:1901363,GO:1901564,GO:1990258,GO:1990259	-	ko:K04795	-	-	-	-	ko00000,ko03009	-	-	-	Fibrillarin
MMS3_k127_1933916_5	72658.Bostr.7867s1295.1.p	1.173e-05	56.0	COG1498@1|root,KOG2427@1|root,KOG2427@2759|Eukaryota,KOG2572@2759|Eukaryota,37JT9@33090|Viridiplantae,3GGZ8@35493|Streptophyta,3HYJE@3699|Brassicales	35493|Streptophyta	AJ	Nucleolar protein	-	-	-	ko:K14565	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	NOP5NT,Nop
MMS3_k127_1933916_0	565033.GACE_1347	5.604e-141	462.0	COG0034@1|root,arCOG00093@2157|Archaea,2XSWJ@28890|Euryarchaeota,245VK@183980|Archaeoglobi	183980|Archaeoglobi	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_7,Pribosyltran
MMS3_k127_1933916_4	529709.PYCH_18210	2.272e-25	108.0	COG2058@1|root,arCOG04287@2157|Archaea,2XYQ9@28890|Euryarchaeota,244BE@183968|Thermococci	183968|Thermococci	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rpl12	-	-	ko:K02869	ko03010,map03010	M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_60s
MMS3_k127_1933916_2	1236689.MMALV_00500	9.128e-54	199.0	COG0244@1|root,arCOG04288@2157|Archaea,2XU7C@28890|Euryarchaeota,3F2JW@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rpl10	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_60s,Ribosomal_L10
MMS3_k127_1933916_1	439481.Aboo_0862	7.136e-65	227.0	COG0081@1|root,arCOG04289@2157|Archaea,2XTJF@28890|Euryarchaeota,3F2IX@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Binds directly to 23S rRNA. Probably involved in E site tRNA release	rpl1	GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
MMS3_k127_1971655_0	429009.Adeg_0440	7.18e-72	255.0	COG0469@1|root,COG0469@2|Bacteria,1TPGG@1239|Firmicutes,2489V@186801|Clostridia,42F1S@68295|Thermoanaerobacterales	186801|Clostridia	G	Belongs to the pyruvate kinase family	pyk	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PEP-utilizers,PK,PK_C
MMS3_k127_1971655_6	471881.PROPEN_03501	2.851e-10	72.0	COG2271@1|root,COG2271@2|Bacteria,1MVPS@1224|Proteobacteria,1RNMV@1236|Gammaproteobacteria,3Z3CZ@583|Proteus	1236|Gammaproteobacteria	G	Organic Anion Transporter Polypeptide (OATP) family	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS3_k127_1971655_1	266117.Rxyl_2947	2.763e-62	225.0	COG0491@1|root,COG0491@2|Bacteria,2I9GW@201174|Actinobacteria,4CPW8@84995|Rubrobacteria	84995|Rubrobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
MMS3_k127_1971655_4	673860.AciM339_0571	5.312e-26	119.0	COG1994@1|root,arCOG00614@2157|Archaea,2XX7B@28890|Euryarchaeota,3F2QP@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Peptidase family M50	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_1971655_2	266117.Rxyl_3164	2.31e-59	216.0	COG0614@1|root,COG0614@2|Bacteria,2GM6R@201174|Actinobacteria,4CQ1N@84995|Rubrobacteria	84995|Rubrobacteria	P	Periplasmic binding protein	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
MMS3_k127_1971655_7	159087.Daro_1943	6.634e-07	61.0	COG0457@1|root,COG0457@2|Bacteria,1MXMD@1224|Proteobacteria,2VPB3@28216|Betaproteobacteria,2KVVY@206389|Rhodocyclales	206389|Rhodocyclales	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_4,TPR_8
MMS3_k127_1971655_3	673860.AciM339_1453	3.989e-51	195.0	COG0142@1|root,arCOG01726@2157|Archaea,2XTAC@28890|Euryarchaeota,3F2QZ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	Polyprenyl synthetase	idsA	GO:0003674,GO:0003824,GO:0004659,GO:0016740,GO:0016765	2.5.1.1,2.5.1.10,2.5.1.29,2.5.1.90	ko:K02523,ko:K13787	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365	R01658,R02003,R02061,R09248	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
MMS3_k127_1971655_5	439481.Aboo_1123	2.066e-16	87.0	COG1382@1|root,arCOG01342@2157|Archaea,2XX88@28890|Euryarchaeota,3F2W4@33867|unclassified Euryarchaeota	28890|Euryarchaeota	O	Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding	pfdB	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006457,GO:0006996,GO:0007010,GO:0008150,GO:0009987,GO:0016043,GO:0016272,GO:0022607,GO:0032991,GO:0034622,GO:0043933,GO:0044085,GO:0044424,GO:0044464,GO:0051087,GO:0051131,GO:0065003,GO:0071840	-	ko:K04798	-	-	-	-	ko00000,ko03110	-	-	-	Prefoldin_2
MMS3_k127_2034011_1	1042877.GQS_01745	1.519e-33	140.0	COG1867@1|root,arCOG01219@2157|Archaea,2XTUF@28890|Euryarchaeota,243GQ@183968|Thermococci	183968|Thermococci	J	Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups	trm1	GO:0001510,GO:0002940,GO:0003674,GO:0003824,GO:0004809,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.215,2.1.1.216	ko:K00555	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TRM
MMS3_k127_2034011_0	1054217.TALC_01538	6.973e-169	565.0	COG1201@1|root,arCOG00557@2157|Archaea,2XSTH@28890|Euryarchaeota,241ID@183967|Thermoplasmata	183967|Thermoplasmata	L	helicase superfamily c-terminal domain	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
MMS3_k127_2034011_2	511051.CSE_12130	2.309e-11	72.0	COG1661@1|root,COG1661@2|Bacteria	2|Bacteria	O	DNA-binding protein with PD1-like DNA-binding motif	-	-	-	ko:K06934	-	-	-	-	ko00000	-	-	-	DUF296
MMS3_k127_2067583_1	1463856.JOHY01000001_gene428	5.387e-34	140.0	COG2025@1|root,COG2086@1|root,COG2025@2|Bacteria,COG2086@2|Bacteria,2IIH6@201174|Actinobacteria	201174|Actinobacteria	C	Electron transfer flavoprotein FAD-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	ETF,ETF_alpha
MMS3_k127_2067583_0	644966.Tmar_0614	6.554e-87	301.0	COG3342@1|root,COG3342@2|Bacteria,1TS8U@1239|Firmicutes,24DS0@186801|Clostridia	186801|Clostridia	S	Peptidoglycan binding	-	-	-	-	-	-	-	-	-	-	-	-	DUF1028,PG_binding_2
MMS3_k127_208451_0	1054217.TALC_00966	2.679e-170	567.0	COG0495@1|root,arCOG00809@2157|Archaea,2XU7M@28890|Euryarchaeota,241JC@183967|Thermoplasmata	183967|Thermoplasmata	J	leucyl-tRNA aminoacylation	leuS	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1
MMS3_k127_208451_2	1123073.KB899241_gene3426	1.129e-54	198.0	COG0602@1|root,COG0602@2|Bacteria,1MUJ2@1224|Proteobacteria,1RNQZ@1236|Gammaproteobacteria,1X4FR@135614|Xanthomonadales	135614|Xanthomonadales	H	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds	queE	-	4.3.99.3	ko:K10026	ko00790,ko01100,map00790,map01100	-	R10002	RC02989	ko00000,ko00001,ko01000,ko03016	-	-	-	Fer4_14,Radical_SAM
MMS3_k127_208451_1	439481.Aboo_0536	1.499e-110	372.0	COG0371@1|root,arCOG00982@2157|Archaea,2XT0F@28890|Euryarchaeota,3F2IT@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea	egsA	-	1.1.1.261	ko:K00096	ko00564,map00564	-	R05679,R05680	RC00029	ko00000,ko00001,ko01000	-	-	-	Fe-ADH_2
MMS3_k127_208451_3	1033806.HTIA_0326	2.877e-18	88.0	COG1860@1|root,arCOG04477@2157|Archaea,2XX8X@28890|Euryarchaeota,23VKU@183963|Halobacteria	183963|Halobacteria	S	Belongs to the UPF0179 family	-	-	-	ko:K09730	-	-	-	-	ko00000	-	-	-	UPF0179
MMS3_k127_2086205_3	1382356.JQMP01000003_gene1420	3.621e-23	103.0	COG0276@1|root,COG0276@2|Bacteria,2G6A2@200795|Chloroflexi,27XJN@189775|Thermomicrobia	189775|Thermomicrobia	H	Catalyzes the ferrous insertion into protoporphyrin IX	hemH	-	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	Ferrochelatase
MMS3_k127_2086205_8	649638.Trad_0185	0.0002625	53.0	COG4099@1|root,COG4099@2|Bacteria,1WMQ4@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Phospholipase/Carboxylesterase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_2,Esterase_phd
MMS3_k127_2086205_5	439481.Aboo_1307	1.869e-16	85.0	arCOG05357@1|root,arCOG05357@2157|Archaea,2Y1B1@28890|Euryarchaeota,3F2VN@33867|unclassified Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_2086205_0	439481.Aboo_0003	7.124e-47	172.0	COG0231@1|root,arCOG04277@2157|Archaea,2XX3E@28890|Euryarchaeota,3F2PU@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Functions by promoting the formation of the first peptide bond	eif5a	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03263	-	-	-	-	ko00000,ko03012	-	-	-	EFP_N,eIF-5a
MMS3_k127_2086205_6	416591.Tlet_0382	2.76e-15	92.0	COG0060@1|root,COG0060@2|Bacteria,2GC5I@200918|Thermotogae	200918|Thermotogae	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
MMS3_k127_2086205_1	251221.35213025	2.451e-40	173.0	COG3055@1|root,COG3055@2|Bacteria	2|Bacteria	G	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,Kelch_1,Kelch_6
MMS3_k127_2086205_7	886379.AEWI01000013_gene2213	6.833e-11	76.0	COG2373@1|root,COG4386@1|root,COG2373@2|Bacteria,COG4386@2|Bacteria,4PP8A@976|Bacteroidetes	976|Bacteroidetes	S	Immunoglobulin	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_2086205_2	1321778.HMPREF1982_02329	1.557e-28	126.0	COG0500@1|root,COG2226@2|Bacteria,1TSBS@1239|Firmicutes,253MR@186801|Clostridia	186801|Clostridia	Q	Mycolic acid cyclopropane synthetase	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_2086205_4	1464048.JNZS01000010_gene5292	1.24e-18	96.0	COG2230@1|root,COG2230@2|Bacteria,2I82K@201174|Actinobacteria,4DE98@85008|Micromonosporales	201174|Actinobacteria	M	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_12,Methyltransf_25,Methyltransf_31
MMS3_k127_2105008_1	224325.AF_2058	4.826e-49	184.0	COG2237@1|root,arCOG04151@2157|Archaea,2XTV5@28890|Euryarchaeota,2463A@183980|Archaeoglobi	183980|Archaeoglobi	S	Domain of unknown function (DUF373)	-	-	-	ko:K08975	-	-	-	-	ko00000	-	-	-	DUF373
MMS3_k127_2105008_0	1054217.TALC_00148	2.573e-135	445.0	COG0008@1|root,arCOG00402@2157|Archaea,2XSUM@28890|Euryarchaeota,241KP@183967|Thermoplasmata	183967|Thermoplasmata	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro)	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,ProRS-C_1,tRNA-synt_2b
MMS3_k127_2105008_3	420324.KI912086_gene7293	3.894e-11	76.0	COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,1JR57@119045|Methylobacteriaceae	28211|Alphaproteobacteria	T	Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,DZR,Guanylate_cyc,SAM_1
MMS3_k127_2105008_2	926550.CLDAP_09410	7.921e-37	160.0	COG2909@1|root,COG3899@1|root,COG2909@2|Bacteria,COG3899@2|Bacteria,2G80F@200795|Chloroflexi	200795|Chloroflexi	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
MMS3_k127_2106835_1	671065.MetMK1DRAFT_00025790	3.735e-53	201.0	COG0095@1|root,arCOG01939@2157|Archaea	2157|Archaea	H	PFAM Biotin lipoate A B protein ligase	lpl	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
MMS3_k127_2106835_4	273057.SSO1125	2.174e-28	121.0	COG2044@1|root,arCOG02066@2157|Archaea	2157|Archaea	O	PFAM DsrE family protein	-	GO:0008150,GO:0009987,GO:0019725,GO:0042592,GO:0048878,GO:0055082,GO:0065007,GO:0065008	-	ko:K07092	-	-	-	-	ko00000	-	-	-	DrsE,DrsE_2,TusA
MMS3_k127_2106835_3	930945.SiRe_1032	3.797e-40	167.0	COG0509@1|root,arCOG01303@2157|Archaea	2157|Archaea	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH2	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
MMS3_k127_2106835_0	330779.Saci_0325	1.821e-79	285.0	COG2048@1|root,arCOG00338@2157|Archaea	2157|Archaea	C	Heterodisulfide reductase, subunit B	hdrB1	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K00241,ko:K03389	ko00020,ko00190,ko00650,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00356,M00357,M00374,M00376,M00563,M00567	R02164,R04540,R11928,R11931,R11943,R11944	RC00011,RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
MMS3_k127_2106835_2	224324.aq_398	3.755e-41	160.0	COG1150@1|root,COG1150@2|Bacteria	2|Bacteria	C	4Fe-4S dicluster domain	hdrC	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389,ko:K03390,ko:K16887,ko:K18930,ko:K22482	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_3424	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_17,Fer4_7,Fer4_8,Fer4_9
MMS3_k127_2106835_5	273057.SSO1133	1.221e-05	55.0	arCOG05916@1|root,arCOG05916@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_2134714_5	479434.Sthe_1089	1.846e-72	261.0	COG3280@1|root,COG3280@2|Bacteria,2G7QP@200795|Chloroflexi,27YWA@189775|Thermomicrobia	189775|Thermomicrobia	G	Alpha amylase, catalytic domain	-	-	5.4.99.15	ko:K06044	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R01824,R09995	-	ko00000,ko00001,ko00002,ko01000	-	GH13	-	Alpha-amylase
MMS3_k127_2134714_2	1121468.AUBR01000021_gene2825	8.781e-262	833.0	COG1449@1|root,COG1449@2|Bacteria,1UVAN@1239|Firmicutes,24B0Y@186801|Clostridia,42HS1@68295|Thermoanaerobacterales	186801|Clostridia	G	Domain of unknown function (DUF3536)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3536,Glyco_hydro_57
MMS3_k127_2134714_3	1121468.AUBR01000021_gene2826	2.308e-189	609.0	COG0296@1|root,COG0296@2|Bacteria,1TP4M@1239|Firmicutes,247WH@186801|Clostridia,42FTG@68295|Thermoanaerobacterales	186801|Clostridia	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18,3.2.1.141	ko:K00700,ko:K01236	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110,R09995,R11256	RC00049	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48,DUF3459
MMS3_k127_2134714_1	309801.trd_1933	8.186e-297	922.0	COG0296@1|root,COG0296@2|Bacteria,2G5IR@200795|Chloroflexi,27XZS@189775|Thermomicrobia	189775|Thermomicrobia	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
MMS3_k127_2134714_4	370438.PTH_1585	9.288e-108	377.0	COG1640@1|root,COG1640@2|Bacteria,1W5VQ@1239|Firmicutes,25E46@186801|Clostridia,2610T@186807|Peptococcaceae	186801|Clostridia	G	PFAM glycoside hydrolase family 77	malQ	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
MMS3_k127_2134714_0	1382356.JQMP01000004_gene486	0.0	1115.0	COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,2G86T@200795|Chloroflexi,27XQK@189775|Thermomicrobia	189775|Thermomicrobia	G	Alpha-amylase domain	-	-	3.2.1.1,5.4.99.16	ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R02108,R02112,R11262	RC01816	ko00000,ko00001,ko01000	-	GH13	-	APH,Alpha-amylase,Malt_amylase_C
MMS3_k127_2147009_2	648996.Theam_1600	1.473e-102	349.0	COG0001@1|root,COG0001@2|Bacteria,2G3VU@200783|Aquificae	200783|Aquificae	H	PFAM Aminotransferase class-III	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
MMS3_k127_2147009_5	1121428.DESHY_60298___1	9.336e-63	229.0	COG0601@1|root,COG0601@2|Bacteria,1TP1S@1239|Firmicutes,247IP@186801|Clostridia,260KR@186807|Peptococcaceae	186801|Clostridia	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
MMS3_k127_2147009_6	1144310.PMI07_004779	6.168e-62	225.0	COG1173@1|root,COG1173@2|Bacteria,1MW3R@1224|Proteobacteria,2TUCW@28211|Alphaproteobacteria,4BNAM@82115|Rhizobiaceae	28211|Alphaproteobacteria	EP	N-terminal TM domain of oligopeptide transport permease C	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1,OppC_N
MMS3_k127_2147009_4	867903.ThesuDRAFT_01537	1.416e-78	296.0	COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,247NN@186801|Clostridia	186801|Clostridia	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
MMS3_k127_2147009_3	1380394.JADL01000004_gene5946	7e-91	329.0	COG4608@1|root,COG4608@2|Bacteria,1NU4K@1224|Proteobacteria,2TQTV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Belongs to the ABC transporter superfamily	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,oligo_HPY
MMS3_k127_2147009_7	930945.SiRe_2281	5.217e-52	206.0	COG0747@1|root,arCOG01534@2157|Archaea,2XPZY@28889|Crenarchaeota	28889|Crenarchaeota	E	PFAM extracellular solute-binding protein, family 5	dppA	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
MMS3_k127_2147009_0	395961.Cyan7425_2741	3.318e-149	487.0	COG1012@1|root,COG1012@2|Bacteria,1G1BD@1117|Cyanobacteria,3KGCF@43988|Cyanothece	1117|Cyanobacteria	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.16,1.2.1.20,1.2.1.3,1.2.1.39,1.2.1.79,1.2.1.8	ko:K00128,ko:K00130,ko:K00135,ko:K00138,ko:K00146	ko00010,ko00053,ko00071,ko00250,ko00260,ko00280,ko00310,ko00330,ko00340,ko00350,ko00360,ko00380,ko00410,ko00561,ko00620,ko00625,ko00643,ko00650,ko00760,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00250,map00260,map00280,map00310,map00330,map00340,map00350,map00360,map00380,map00410,map00561,map00620,map00625,map00643,map00650,map00760,map00903,map00981,map01100,map01110,map01120,map01130	M00027,M00135,M00555	R00264,R00631,R00710,R00711,R00713,R00714,R00904,R01752,R01986,R02401,R02536,R02549,R02565,R02566,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
MMS3_k127_2147009_1	399549.Msed_1774	4.917e-118	397.0	COG1012@1|root,arCOG01252@2157|Archaea,2XRNH@28889|Crenarchaeota	28889|Crenarchaeota	C	PFAM Aldehyde dehydrogenase	-	-	1.2.1.76	ko:K15038	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00374,M00375	R09280	RC00004,RC00184	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
MMS3_k127_2147009_8	1089547.KB913013_gene4193	0.0005062	51.0	COG2374@1|root,COG5276@1|root,COG2374@2|Bacteria,COG5276@2|Bacteria	2|Bacteria	-	-	nucH	-	3.1.3.5	ko:K01081,ko:K07004	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	5_nucleotid_C,Calx-beta,Exo_endo_phos,He_PIG,LTD,Metallophos
MMS3_k127_2152485_0	224325.AF_0710	2.524e-84	295.0	COG0574@1|root,arCOG01111@2157|Archaea,2XU2T@28890|Euryarchaeota,245QA@183980|Archaeoglobi	183980|Archaeoglobi	G	PFAM Pyruvate phosphate dikinase, PEP	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
MMS3_k127_2152485_1	273075.Ta0836	8.108e-28	121.0	COG2520@1|root,arCOG00033@2157|Archaea,2XTSI@28890|Euryarchaeota,241R8@183967|Thermoplasmata	183967|Thermoplasmata	J	Met-10+ like-protein	-	-	2.1.1.228	ko:K15429	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	Met_10
MMS3_k127_2264556_8	593750.Metfor_2004	1.805e-18	93.0	COG0301@1|root,arCOG00038@2157|Archaea,2XUHM@28890|Euryarchaeota,2N98H@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	thiI	-	2.8.1.4	ko:K03151	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07461	-	ko00000,ko00001,ko01000,ko03016	-	-	-	THUMP,ThiI
MMS3_k127_2264556_1	1041930.Mtc_0138	4.647e-107	372.0	COG0018@1|root,arCOG00487@2157|Archaea,2XTWP@28890|Euryarchaeota,2N9C5@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
MMS3_k127_2264556_5	642492.Clole_2702	7.552e-31	126.0	COG1970@1|root,COG1970@2|Bacteria,1VA14@1239|Firmicutes,24JAB@186801|Clostridia	186801|Clostridia	M	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell	mscL	-	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
MMS3_k127_2264556_3	404589.Anae109_3919	1.486e-61	230.0	COG0603@1|root,COG0603@2|Bacteria,1MU5V@1224|Proteobacteria,42MKZ@68525|delta/epsilon subdivisions,2WING@28221|Deltaproteobacteria,2Z04D@29|Myxococcales	28221|Deltaproteobacteria	F	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))	queC	-	6.3.4.20	ko:K06920	ko00790,ko01100,map00790,map01100	-	R09978	RC00959	ko00000,ko00001,ko01000,ko03016	-	-	iAF987.Gmet_3075	QueC
MMS3_k127_2264556_6	273075.Ta0520	1.037e-20	107.0	COG1836@1|root,arCOG02245@2157|Archaea,2XTBR@28890|Euryarchaeota,241UU@183967|Thermoplasmata	183967|Thermoplasmata	S	Integral membrane protein DUF92	-	-	-	-	-	-	-	-	-	-	-	-	DUF92
MMS3_k127_2264556_4	742735.HMPREF9467_01698	1.519e-34	153.0	COG0241@1|root,COG0241@2|Bacteria,1V6XD@1239|Firmicutes,24IZ4@186801|Clostridia,21Z1E@1506553|Lachnoclostridium	186801|Clostridia	E	Polynucleotide kinase 3 phosphatase	gmhB	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0034200,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914	3.1.3.82,3.1.3.83	ko:K03273	ko00540,ko01100,map00540,map01100	M00064	R05647,R09771	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hydrolase_6,Hydrolase_like,PNK3P
MMS3_k127_2264556_7	439481.Aboo_0733	1.278e-20	101.0	COG0367@1|root,arCOG00071@2157|Archaea,2XSYP@28890|Euryarchaeota,3F3FU@33867|unclassified Euryarchaeota	28890|Euryarchaeota	E	Asparagine synthase	asnB	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_6,GATase_7
MMS3_k127_2264556_2	367299.JOEE01000007_gene55	6.035e-71	257.0	COG0549@1|root,COG0549@2|Bacteria,2HWQ6@201174|Actinobacteria,4FFY6@85021|Intrasporangiaceae	201174|Actinobacteria	E	Belongs to the carbamate kinase family	arcC	-	2.7.2.2	ko:K00926	ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200	-	R00150,R01395	RC00002,RC00043,RC02803,RC02804	ko00000,ko00001,ko01000	-	-	-	AA_kinase
MMS3_k127_2264556_0	1236689.MMALV_07730	6.233e-109	375.0	COG0015@1|root,arCOG01747@2157|Archaea,2XUQ5@28890|Euryarchaeota,3F2GT@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	purB	GO:0003674,GO:0003824,GO:0004018,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016840,GO:0016842,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046033,GO:0046390,GO:0046483,GO:0055086,GO:0070626,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
MMS3_k127_2282009_5	1506583.JQJY01000010_gene1158	2.009e-06	62.0	COG2911@1|root,COG3209@1|root,COG2911@2|Bacteria,COG3209@2|Bacteria,4PKBQ@976|Bacteroidetes,1IJ6N@117743|Flavobacteriia,2NSCF@237|Flavobacterium	976|Bacteroidetes	M	SprB repeat	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,Laminin_G_3,SprB
MMS3_k127_2282009_3	1120949.KB903294_gene4173	4.911e-53	194.0	COG0346@1|root,COG0346@2|Bacteria,2IFMD@201174|Actinobacteria,4DM35@85008|Micromonosporales	201174|Actinobacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_2282009_0	666510.ASAC_0901	1.344e-153	503.0	arCOG00144@1|root,arCOG00144@2157|Archaea,2XQ4R@28889|Crenarchaeota	28889|Crenarchaeota	G	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS3_k127_2282009_2	273116.14324380	2.768e-68	254.0	COG1131@1|root,arCOG00194@2157|Archaea,2XT0T@28890|Euryarchaeota,241QI@183967|Thermoplasmata	183967|Thermoplasmata	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
MMS3_k127_2282009_4	273116.14324381	2.357e-30	131.0	COG1277@1|root,arCOG03689@2157|Archaea,2Y0MI@28890|Euryarchaeota,2425Y@183967|Thermoplasmata	183967|Thermoplasmata	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
MMS3_k127_2282009_7	1089547.KB913013_gene4133	0.0004133	54.0	COG1874@1|root,COG2133@1|root,COG2374@1|root,COG1874@2|Bacteria,COG2133@2|Bacteria,COG2374@2|Bacteria	2|Bacteria	G	pyrroloquinoline quinone binding	nucH	-	3.1.3.5,3.2.1.97	ko:K01081,ko:K07004,ko:K17624	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	GH101	-	Calx-beta,Exo_endo_phos,F5_F8_type_C,GSDH,Glyco_hyd_101C,Glyco_hydro_101,He_PIG,LTD,NPCBM,NPCBM_assoc
MMS3_k127_2282009_1	479432.Sros_4642	1.565e-106	352.0	COG0454@1|root,COG0456@2|Bacteria,2I8Y1@201174|Actinobacteria	201174|Actinobacteria	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
MMS3_k127_2282009_6	269798.CHU_3788	0.000154	49.0	COG3631@1|root,COG3631@2|Bacteria,4NYK0@976|Bacteroidetes,47WD5@768503|Cytophagia	976|Bacteroidetes	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
MMS3_k127_233329_1	1094980.Mpsy_0403	3.965e-40	156.0	COG3808@1|root,arCOG04949@2157|Archaea,2XTDB@28890|Euryarchaeota,2N98C@224756|Methanomicrobia	224756|Methanomicrobia	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
MMS3_k127_233329_0	644966.Tmar_0825	4.005e-181	589.0	COG0441@1|root,COG0441@2|Bacteria,1TP78@1239|Firmicutes,248CH@186801|Clostridia,3WCD0@538999|Clostridiales incertae sedis	186801|Clostridia	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
MMS3_k127_233329_2	1047013.AQSP01000122_gene2224	2.432e-15	89.0	COG3291@1|root,COG5434@1|root,COG3291@2|Bacteria,COG5434@2|Bacteria,2NQ6Y@2323|unclassified Bacteria	2|Bacteria	M	PKD domain	-	-	3.2.1.157,3.2.1.91	ko:K19668,ko:K20850	ko00500,ko01100,ko02020,map00500,map01100,map02020	-	R02886,R11308	RC00799	ko00000,ko00001,ko01000	-	GH6,GH82	-	Beta_helix,CHU_C,Cadherin-like,FlgD_ig,PKD,Pectate_lyase_3
MMS3_k127_2365108_2	1111135.HMPREF1248_1150	0.0001086	45.0	COG1243@1|root,COG1243@2|Bacteria	2|Bacteria	BK	radical SAM domain protein	-	-	2.3.1.48	ko:K07739	-	-	-	-	ko00000,ko01000,ko03016,ko03036	-	-	-	Acetyltransf_1,Fer4_14,Radical_SAM,Radical_SAM_C
MMS3_k127_2365108_0	439481.Aboo_1293	1.612e-147	478.0	COG1812@1|root,arCOG01678@2157|Archaea,2XT7J@28890|Euryarchaeota,3F2G8@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	Catalyzes the formation of S-adenosylmethionine from methionine and ATP	mat	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	AdoMet_Synthase
MMS3_k127_2365108_1	521011.Mpal_2762	2.991e-71	258.0	COG0621@1|root,arCOG01358@2157|Archaea,2XSVB@28890|Euryarchaeota,2N9GQ@224756|Methanomicrobia	224756|Methanomicrobia	J	SMART Elongator protein 3 MiaB NifB	miaB	-	2.8.4.5	ko:K15865	-	-	R10649	RC00003,RC03221	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
MMS3_k127_2488127_3	673860.AciM339_0396	3.074e-43	166.0	COG0794@1|root,arCOG00068@2157|Archaea,2XX86@28890|Euryarchaeota,3F2MP@33867|unclassified Euryarchaeota	28890|Euryarchaeota	M	SIS domain	-	-	5.3.1.27	ko:K08094	ko00030,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00680,map01100,map01120,map01200,map01230	M00345,M00580	R05339,R09780	RC00377	ko00000,ko00001,ko00002,ko01000	-	-	-	SIS
MMS3_k127_2488127_1	1236689.MMALV_13720	6.094e-48	178.0	COG1945@1|root,arCOG04490@2157|Archaea	2157|Archaea	S	Pyruvoyl-dependent arginine decarboxylase	pdaD	-	4.1.1.19	ko:K02626	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A2039	PvlArgDC
MMS3_k127_2488127_0	1121920.AUAU01000004_gene898	2.893e-78	273.0	COG1131@1|root,COG1131@2|Bacteria,3Y4CW@57723|Acidobacteria	57723|Acidobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
MMS3_k127_2488127_2	443143.GM18_2743	4.265e-45	182.0	COG0842@1|root,COG0842@2|Bacteria,1Q99P@1224|Proteobacteria,42M53@68525|delta/epsilon subdivisions,2WMEY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane,ABC2_membrane_3
MMS3_k127_2488127_6	439481.Aboo_1200	5.19e-09	68.0	COG3255@1|root,arCOG01843@2157|Archaea,2Y75B@28890|Euryarchaeota,3F3F7@33867|unclassified Euryarchaeota	28890|Euryarchaeota	I	SCP-2 sterol transfer family	-	-	-	-	-	-	-	-	-	-	-	-	SCP2
MMS3_k127_2488127_4	1151117.AJLF01000001_gene1719	9.864e-39	157.0	COG0164@1|root,arCOG04121@2157|Archaea,2XWYC@28890|Euryarchaeota,242VW@183968|Thermococci	183968|Thermococci	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
MMS3_k127_2488127_5	673860.AciM339_1543	6.116e-33	136.0	COG2007@1|root,arCOG04154@2157|Archaea,2XYXX@28890|Euryarchaeota,3F2SE@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Ribosomal protein S8e	rps8e	GO:0000462,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044085,GO:0044237,GO:0044238,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360,GO:1990904	-	ko:K02995	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8e
MMS3_k127_2503085_0	1267533.KB906740_gene331	2.19e-68	237.0	COG0022@1|root,COG0022@2|Bacteria,3Y34Y@57723|Acidobacteria,2JHQ9@204432|Acidobacteriia	2|Bacteria	C	Dehydrogenase E1 component	bfmBA	-	1.2.4.4	ko:K00167,ko:K11381,ko:K21417	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,Transket_pyr,Transketolase_C
MMS3_k127_2503085_6	1397278.AYMV01000007_gene196	2.548e-27	127.0	COG0508@1|root,COG0508@2|Bacteria,2GMUV@201174|Actinobacteria,4FK9I@85023|Microbacteriaceae	201174|Actinobacteria	C	e3 binding domain	sucB	-	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
MMS3_k127_2503085_7	1408813.AYMG01000014_gene1651	3.494e-21	110.0	COG1361@1|root,COG3291@1|root,COG4625@1|root,COG1361@2|Bacteria,COG3291@2|Bacteria,COG4625@2|Bacteria,4NDZC@976|Bacteroidetes,1IRJP@117747|Sphingobacteriia	976|Bacteroidetes	M	C-terminal domain of CHU protein family	-	-	-	ko:K21449	-	-	-	-	ko00000,ko02000	1.B.40.2	-	-	CHU_C,DUF11,He_PIG,fn3
MMS3_k127_2503085_3	485913.Krac_1995	5.656e-45	166.0	COG5649@1|root,COG5649@2|Bacteria	2|Bacteria	E	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
MMS3_k127_2503085_4	1128421.JAGA01000002_gene1136	1.159e-44	175.0	COG5646@1|root,COG5646@2|Bacteria,2NQX2@2323|unclassified Bacteria	2|Bacteria	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
MMS3_k127_2503085_1	661478.OP10G_3971	3.142e-62	229.0	COG1247@1|root,COG1247@2|Bacteria	2|Bacteria	M	phosphinothricin N-acetyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
MMS3_k127_2503085_9	218851.Aquca_074_00035.1	1.504e-05	59.0	COG1520@1|root,2QVST@2759|Eukaryota,388T0@33090|Viridiplantae,3GXGE@35493|Streptophyta	35493|Streptophyta	S	PQQ enzyme repeat	-	-	-	-	-	-	-	-	-	-	-	-	PQQ,PQQ_2
MMS3_k127_2503085_10	153721.MYP_757	7.825e-05	57.0	COG2133@1|root,COG3291@1|root,COG2133@2|Bacteria,COG3291@2|Bacteria,4NIJA@976|Bacteroidetes,47NB2@768503|Cytophagia	976|Bacteroidetes	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1,GSDH,I-set,Ig_3
MMS3_k127_2503085_5	1382306.JNIM01000001_gene1210	9.483e-42	166.0	COG2267@1|root,COG2267@2|Bacteria,2GBHH@200795|Chloroflexi	200795|Chloroflexi	I	Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC)	menH	-	4.2.99.20	ko:K08680	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R08166	RC02148,RC02475	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1,Abhydrolase_6
MMS3_k127_2503085_2	1056495.Calag_1003	9.297e-54	216.0	COG3391@1|root,arCOG06052@1|root,arCOG02560@2157|Archaea,arCOG06052@2157|Archaea,2XRYP@28889|Crenarchaeota	28889|Crenarchaeota	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_2503085_8	671065.MetMK1DRAFT_00015180	1.343e-10	75.0	arCOG06052@1|root,arCOG06052@2157|Archaea,2XSHA@28889|Crenarchaeota	28889|Crenarchaeota	S	parallel beta-helix repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_2508885_10	1122138.AQUZ01000013_gene5691	7.878e-07	62.0	COG0627@1|root,COG1520@1|root,COG0627@2|Bacteria,COG1520@2|Bacteria,2GJX4@201174|Actinobacteria,4DQ66@85009|Propionibacteriales	201174|Actinobacteria	S	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
MMS3_k127_2508885_8	953739.SVEN_1003	3.77e-43	173.0	COG0438@1|root,COG0438@2|Bacteria,2GIZG@201174|Actinobacteria	201174|Actinobacteria	M	PFAM Glycosyl transferase, group 1	mgtA	GO:0000030,GO:0003674,GO:0003824,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016740,GO:0016757,GO:0016758,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0070085,GO:0071704,GO:0097502,GO:1901135,GO:1901137,GO:1901576,GO:1903509	-	ko:K12583	-	-	-	-	ko00000,ko01000,ko01003	-	GT4	-	Glyco_transf_4,Glycos_transf_1
MMS3_k127_2508885_7	673860.AciM339_0716	9.928e-44	169.0	COG1545@1|root,arCOG01285@2157|Archaea,2XXGF@28890|Euryarchaeota,3F2RZ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	V	DUF35 OB-fold domain, acyl-CoA-associated	acaC	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
MMS3_k127_2508885_2	456442.Mboo_0156	1.415e-124	409.0	COG0183@1|root,arCOG01278@2157|Archaea,2XT38@28890|Euryarchaeota,2N94P@224756|Methanomicrobia	224756|Methanomicrobia	I	PFAM Thiolase	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iAF692.Mbar_A0550	Thiolase_C,Thiolase_N
MMS3_k127_2508885_1	1236689.MMALV_05610	2.545e-148	476.0	COG3425@1|root,arCOG01767@2157|Archaea,2XTWE@28890|Euryarchaeota,3F2GW@33867|unclassified Euryarchaeota	28890|Euryarchaeota	I	3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal	hmgB	-	2.3.3.10	ko:K01641	ko00072,ko00280,ko00650,ko00900,ko01100,ko01110,ko01130,map00072,map00280,map00650,map00900,map01100,map01110,map01130	M00088,M00095	R01978	RC00004,RC00503	ko00000,ko00001,ko00002,ko01000	-	-	-	ACP_syn_III,ACP_syn_III_C,HMG_CoA_synt_C,HMG_CoA_synt_N
MMS3_k127_2508885_6	439481.Aboo_0718	2.288e-61	221.0	COG1709@1|root,arCOG04060@2157|Archaea,2XT58@28890|Euryarchaeota,3F2M5@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	Helix-turn-helix XRE-family like proteins	-	-	-	ko:K07731	-	-	-	-	ko00000,ko03000	-	-	-	HTH_19,HTH_3,HTH_31
MMS3_k127_2508885_9	263820.PTO0525	3.288e-08	61.0	arCOG05345@1|root,arCOG05345@2157|Archaea,2Y117@28890|Euryarchaeota,242B3@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_2508885_5	673860.AciM339_0285	4.014e-62	229.0	COG1938@1|root,arCOG00347@2157|Archaea,2XT93@28890|Euryarchaeota,3F2T7@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	PAC2 family	-	-	-	ko:K06869	-	-	-	-	ko00000	-	-	-	PAC2
MMS3_k127_2508885_3	1236689.MMALV_07230	2.418e-94	338.0	COG0520@1|root,arCOG00065@2157|Archaea,2XSYI@28890|Euryarchaeota	2157|Archaea	E	Cysteine desulfurase	-	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
MMS3_k127_2508885_4	401526.TcarDRAFT_0169	7.056e-90	311.0	COG1473@1|root,COG1473@2|Bacteria,1TPD7@1239|Firmicutes,4H23X@909932|Negativicutes	909932|Negativicutes	E	amidohydrolase	-	-	-	ko:K01436	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
MMS3_k127_2508885_0	247490.KSU1_C1370	5.587e-232	727.0	COG0443@1|root,COG0443@2|Bacteria,2IWWS@203682|Planctomycetes	203682|Planctomycetes	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
MMS3_k127_2524378_4	644966.Tmar_1290	8.509e-41	160.0	COG1489@1|root,COG1489@2|Bacteria,1V1GZ@1239|Firmicutes,24A0M@186801|Clostridia,3WDHN@538999|Clostridiales incertae sedis	186801|Clostridia	S	Sugar fermentation stimulation protein	sfsA	-	-	ko:K06206	-	-	-	-	ko00000	-	-	-	SfsA
MMS3_k127_2524378_1	935840.JAEQ01000004_gene462	1.942e-119	404.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TREJ@28211|Alphaproteobacteria,43HRR@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	I	Catalyzes the formation of 3-methylbut-2-enoyl CoA from 3-methylbutanoyl CoA	ivd	-	1.3.8.4	ko:K00253	ko00280,ko01100,map00280,map01100	M00036	R04095	RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
MMS3_k127_2524378_0	316274.Haur_2309	8.009e-136	449.0	COG0029@1|root,COG0029@2|Bacteria,2G5JM@200795|Chloroflexi,375AE@32061|Chloroflexia	32061|Chloroflexia	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	-	-	1.4.3.16	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481	RC00006,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
MMS3_k127_2524378_5	1123229.AUBC01000001_gene1765	1.792e-05	57.0	COG0454@1|root,COG0456@2|Bacteria,1RIE6@1224|Proteobacteria,2UF5C@28211|Alphaproteobacteria,3JX20@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	FR47-like protein	rimI	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1,Acetyltransf_10
MMS3_k127_2524378_2	673860.AciM339_0842	5.13e-59	218.0	COG0462@1|root,arCOG00067@2157|Archaea,2XTA8@28890|Euryarchaeota,3F2FN@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran,Pribosyltran_N
MMS3_k127_2524378_3	666510.ASAC_0901	6.938e-50	188.0	arCOG00144@1|root,arCOG00144@2157|Archaea,2XQ4R@28889|Crenarchaeota	28889|Crenarchaeota	G	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS3_k127_2524391_0	234267.Acid_4844	1.11e-222	713.0	COG1164@1|root,COG1164@2|Bacteria,3Y2SB@57723|Acidobacteria	57723|Acidobacteria	E	Angiotensin-converting enzyme	-	-	3.4.15.1	ko:K01283	ko04614,ko04924,ko05142,ko05410,map04614,map04924,map05142,map05410	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	Peptidase_M2
MMS3_k127_2524391_5	330779.Saci_1640	9.147e-19	94.0	COG0589@1|root,arCOG02053@2157|Archaea,2XQTK@28889|Crenarchaeota	28889|Crenarchaeota	T	PFAM UspA domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
MMS3_k127_2524391_4	13333.ERN11365	8.451e-23	110.0	COG1814@1|root,KOG4473@2759|Eukaryota,37J7N@33090|Viridiplantae,3G7NJ@35493|Streptophyta	35493|Streptophyta	S	vacuolar iron transporter	-	GO:0000041,GO:0003674,GO:0005215,GO:0005381,GO:0005384,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005773,GO:0005774,GO:0006810,GO:0006811,GO:0006812,GO:0006826,GO:0006828,GO:0006873,GO:0006875,GO:0006879,GO:0006880,GO:0008150,GO:0008324,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0015075,GO:0015318,GO:0016020,GO:0019725,GO:0022857,GO:0022890,GO:0030001,GO:0030003,GO:0030026,GO:0031090,GO:0034220,GO:0034755,GO:0042221,GO:0042592,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0046873,GO:0046915,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0051179,GO:0051234,GO:0051235,GO:0051238,GO:0051641,GO:0051651,GO:0051716,GO:0055065,GO:0055071,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0070887,GO:0071241,GO:0071248,GO:0071281,GO:0071421,GO:0097577,GO:0098588,GO:0098655,GO:0098660,GO:0098662,GO:0098771,GO:0098805	-	-	-	-	-	-	-	-	-	-	VIT1
MMS3_k127_2524391_3	273075.Ta1117	4.787e-31	135.0	COG3384@1|root,arCOG01730@2157|Archaea,2Y0BA@28890|Euryarchaeota	28890|Euryarchaeota	E	PFAM Extradiol ring-cleavage dioxygenase, class III	-	-	-	ko:K15777	ko00965,map00965	-	R08836	RC00387	ko00000,ko00001,ko01000	-	-	-	LigB
MMS3_k127_2524391_2	345219.Bcoa_2233	1.497e-53	210.0	COG4934@1|root,COG4934@2|Bacteria,1UYFY@1239|Firmicutes,4HFAH@91061|Bacilli	91061|Bacilli	O	Peptidase S53	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8,Pro-kuma_activ
MMS3_k127_2524391_1	290397.Adeh_0508	5.558e-78	273.0	COG0807@1|root,COG0807@2|Bacteria,1MWZR@1224|Proteobacteria,42N2Q@68525|delta/epsilon subdivisions,2X9TY@28221|Deltaproteobacteria,2YV7W@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate	ribA	-	3.5.4.25	ko:K01497	ko00740,ko00790,ko01100,ko01110,ko02024,map00740,map00790,map01100,map01110,map02024	M00125	R00425	RC00293,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydro2
MMS3_k127_2534901_1	1449976.KALB_3654	1.096e-10	69.0	COG0071@1|root,COG0071@2|Bacteria,2IRG0@201174|Actinobacteria,4E6ZT@85010|Pseudonocardiales	201174|Actinobacteria	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
MMS3_k127_2534901_0	1270193.JARP01000002_gene697	1.686e-95	333.0	COG4805@1|root,COG4805@2|Bacteria,4NFAK@976|Bacteroidetes,1HXAT@117743|Flavobacteriia,2NV5I@237|Flavobacterium	976|Bacteroidetes	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
MMS3_k127_2534970_3	439481.Aboo_0139	1.182e-12	81.0	COG4906@1|root,arCOG00568@2157|Archaea	2157|Archaea	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF2206
MMS3_k127_2534970_2	1094980.Mpsy_0258	1.388e-32	146.0	COG1634@1|root,arCOG04303@2157|Archaea,2XT8R@28890|Euryarchaeota,2N9JZ@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6- hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP)	mptE	-	2.7.6.3	ko:K07142	ko00790,map00790	-	R03503	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	MAF_flag10
MMS3_k127_2534970_0	673860.AciM339_0142	1.428e-129	457.0	COG0206@1|root,arCOG02201@2157|Archaea,2XTMW@28890|Euryarchaeota,3F32D@33867|unclassified Euryarchaeota	28890|Euryarchaeota	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ1	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
MMS3_k127_2534970_1	273075.Ta1403	6.621e-108	381.0	arCOG03675@1|root,arCOG03675@2157|Archaea,2Y2KX@28890|Euryarchaeota,2421C@183967|Thermoplasmata	183967|Thermoplasmata	E	Thermopsin	-	-	3.4.23.42	ko:K01385	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Thermopsin
MMS3_k127_2555110_5	397948.Cmaq_0872	0.0004293	46.0	COG2157@1|root,arCOG04175@2157|Archaea	2157|Archaea	J	PFAM Ribosomal LX protein	rplX	-	-	ko:K02944	ko03010,map03010	M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18A
MMS3_k127_2555110_4	351160.RCIX1040	5.312e-09	65.0	COG1730@1|root,arCOG01341@2157|Archaea,2Y0EU@28890|Euryarchaeota,2NBIM@224756|Methanomicrobia	224756|Methanomicrobia	O	Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding	pfdA	-	-	ko:K04797	-	-	-	-	ko00000,ko03110	-	-	-	Prefoldin
MMS3_k127_2555110_0	1042877.GQS_02100	2.508e-96	325.0	COG0552@1|root,arCOG01227@2157|Archaea,2XUBI@28890|Euryarchaeota,242QW@183968|Thermococci	183968|Thermococci	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
MMS3_k127_2555110_2	1054217.TALC_00047	4.12e-32	143.0	COG0565@1|root,arCOG01018@2157|Archaea,2XUIY@28890|Euryarchaeota,241SK@183967|Thermoplasmata	183967|Thermoplasmata	J	SpoU rRNA Methylase family	-	-	-	-	-	-	-	-	-	-	-	-	SpoU_methylase
MMS3_k127_2555110_1	877455.Metbo_2192	1.273e-56	205.0	COG1632@1|root,arCOG04209@2157|Archaea,2XTJJ@28890|Euryarchaeota,23NJV@183925|Methanobacteria	183925|Methanobacteria	J	Belongs to the eukaryotic ribosomal protein eL15 family	rpl15e	-	-	ko:K02877	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L15e
MMS3_k127_2555110_3	673860.AciM339_1080	8.534e-13	76.0	COG1658@1|root,arCOG01486@2157|Archaea,2Y18J@28890|Euryarchaeota,3F2UV@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	TOPRIM	-	-	-	-	-	-	-	-	-	-	-	-	Toprim
MMS3_k127_2555617_0	1236689.MMALV_16300	6.338e-135	465.0	COG2511@1|root,arCOG01719@2157|Archaea,2XT73@28890|Euryarchaeota,3F2IW@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate	gatE	GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.3.5.7	ko:K03330	ko00970,ko01100,map00970,map01100	-	R03905	RC00010	ko00000,ko00001,ko01000	-	-	-	GAD,GatB_N,GatB_Yqey
MMS3_k127_2555617_1	666510.ASAC_1311	3.225e-94	326.0	COG0252@1|root,arCOG01924@2157|Archaea,2XPTP@28889|Crenarchaeota	28889|Crenarchaeota	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate	gatD	-	6.3.5.7	ko:K09482	ko00970,ko01100,map00970,map01100	-	R03905	RC00010	ko00000,ko00001,ko01000	-	-	-	Asparaginase
MMS3_k127_2555617_3	926690.KE386573_gene301	3.109e-09	68.0	COG3413@1|root,arCOG02272@2157|Archaea,2XUBY@28890|Euryarchaeota,23UBQ@183963|Halobacteria	183963|Halobacteria	K	DNA binding protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_10
MMS3_k127_2555617_4	1261545.MBE-HAL_0225	0.0001999	50.0	COG1605@1|root,arCOG02098@2157|Archaea,2XYXR@28890|Euryarchaeota,23W2B@183963|Halobacteria	183963|Halobacteria	E	chorismate mutase	aroQ	-	5.4.99.5	ko:K04093	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R01715	RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	CM_2
MMS3_k127_2555617_2	671065.MetMK1DRAFT_00014570	2.518e-79	280.0	COG0826@1|root,arCOG03202@2157|Archaea	2157|Archaea	O	PFAM peptidase U32	-	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_U32
MMS3_k127_261628_1	309801.trd_A0767	3.229e-28	125.0	COG1268@1|root,COG1268@2|Bacteria,2GBUZ@200795|Chloroflexi,27YWE@189775|Thermomicrobia	189775|Thermomicrobia	S	BioY family	-	-	-	ko:K03523	ko02010,map02010	M00581,M00582	-	-	ko00000,ko00001,ko00002,ko02000	2.A.88.1,2.A.88.2	-	-	BioY
MMS3_k127_261628_0	671065.MetMK1DRAFT_00018100	1.712e-95	329.0	COG1914@1|root,arCOG04531@2157|Archaea	2157|Archaea	P	COG1914 Mn2 and Fe2 transporters of the NRAMP family	-	-	-	-	-	-	-	-	-	-	-	-	Nramp
MMS3_k127_2638867_4	1333523.L593_09495	2.714e-08	59.0	COG1303@1|root,arCOG01857@2157|Archaea,2XV35@28890|Euryarchaeota,23TU8@183963|Halobacteria	183963|Halobacteria	J	Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs	trm56	-	2.1.1.206	ko:K07254	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Trm56
MMS3_k127_2638867_1	1054217.TALC_01532	9.579e-49	179.0	COG4860@1|root,arCOG04366@2157|Archaea,2XYAX@28890|Euryarchaeota,241R5@183967|Thermoplasmata	183967|Thermoplasmata	K	ArsR transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	ArsR
MMS3_k127_2638867_5	269797.Mbar_A1566	4.586e-06	58.0	COG2260@1|root,arCOG00906@2157|Archaea,2Y1HX@28890|Euryarchaeota,2NA3J@224756|Methanomicrobia	224756|Methanomicrobia	J	more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA	nop10	-	-	ko:K11130	ko03008,map03008	M00425	-	-	ko00000,ko00001,ko00002,ko03009,ko03032	-	-	-	Nop10p
MMS3_k127_2638867_0	439481.Aboo_1152	1.791e-77	268.0	COG1093@1|root,arCOG04107@2157|Archaea,2XTV0@28890|Euryarchaeota,3F2GS@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA	eif2a	GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K03237	ko03013,ko04138,ko04140,ko04141,ko04210,ko04932,ko05160,ko05162,ko05164,ko05168,map03013,map04138,map04140,map04141,map04210,map04932,map05160,map05162,map05164,map05168	-	-	-	ko00000,ko00001,ko03012	-	-	-	EIF_2_alpha,S1
MMS3_k127_2638867_3	323259.Mhun_1129	9.776e-12	71.0	COG2051@1|root,arCOG04108@2157|Archaea,2XZW2@28890|Euryarchaeota,2NA0J@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM Ribosomal protein S27E	rps27e	-	-	ko:K02978	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S27e
MMS3_k127_2638867_2	1054217.TALC_00297	8.331e-30	121.0	COG1631@1|root,arCOG04109@2157|Archaea,2XXV3@28890|Euryarchaeota,241RG@183967|Thermoplasmata	183967|Thermoplasmata	J	Binds to the 23S rRNA	rpl44e	-	-	ko:K02929	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L44
MMS3_k127_2649980_0	6500.XP_005110462.1	1.74e-10	73.0	COG0681@1|root,KOG3342@2759|Eukaryota,38Y2A@33154|Opisthokonta,3BF7K@33208|Metazoa,3CR9T@33213|Bilateria	33208|Metazoa	U	signal peptidase complex catalytic subunit	SEC11A	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005787,GO:0005789,GO:0006465,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0010467,GO:0012505,GO:0016020,GO:0016485,GO:0016787,GO:0019538,GO:0031090,GO:0031984,GO:0032991,GO:0034641,GO:0042175,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043603,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0051604,GO:0071704,GO:0098796,GO:0098827,GO:0140096,GO:1901564,GO:1902494,GO:1905368	3.4.21.89	ko:K13280	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
MMS3_k127_2733492_6	479434.Sthe_0823	1.244e-54	203.0	COG1024@1|root,COG1024@2|Bacteria,2G5JW@200795|Chloroflexi,27XKS@189775|Thermomicrobia	189775|Thermomicrobia	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	-	ECH_1
MMS3_k127_2733492_10	383372.Rcas_2488	3.538e-46	176.0	COG1028@1|root,COG1028@2|Bacteria,2G5KB@200795|Chloroflexi,375B5@32061|Chloroflexia	32061|Chloroflexia	IQ	short-chain dehydrogenase reductase SDR	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
MMS3_k127_2733492_15	1448860.BBJO01000026_gene105	2.083e-31	141.0	COG1498@1|root,arCOG01923@2157|Archaea,2XUEA@28890|Euryarchaeota,23SHK@183963|Halobacteria	183963|Halobacteria	J	COG1498 Protein implicated in ribosomal biogenesis, Nop56p homolog	nop5	-	-	ko:K14564	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	Nop
MMS3_k127_2733492_8	1191523.MROS_0441	4.534e-49	181.0	COG1225@1|root,COG1225@2|Bacteria	2|Bacteria	O	peroxiredoxin activity	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
MMS3_k127_2733492_24	1397693.KK211187_gene2240	0.0001391	53.0	COG0095@1|root,COG0095@2|Bacteria,1TQ5U@1239|Firmicutes,4HABG@91061|Bacilli	91061|Bacilli	H	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation	lipM	GO:0003674,GO:0003824,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016415,GO:0016740,GO:0016746,GO:0016747,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
MMS3_k127_2733492_3	1236689.MMALV_02630	2.824e-117	391.0	COG0402@1|root,arCOG00695@2157|Archaea,2XTJS@28890|Euryarchaeota,3F2GI@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	Amidohydrolase family	dadD	-	3.5.4.28,3.5.4.31	ko:K12960	ko00270,ko01100,map00270,map01100	-	R09660	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
MMS3_k127_2733492_0	1449126.JQKL01000061_gene1910	3.13e-249	784.0	COG0187@1|root,COG0187@2|Bacteria,1TQ0R@1239|Firmicutes,248AV@186801|Clostridia,2682S@186813|unclassified Clostridiales	186801|Clostridia	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
MMS3_k127_2733492_18	717606.PaecuDRAFT_0243	8.089e-21	99.0	COG0576@1|root,COG0576@2|Bacteria,1V6G2@1239|Firmicutes,4HIRK@91061|Bacilli,26X19@186822|Paenibacillaceae	91061|Bacilli	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	GO:0000166,GO:0000774,GO:0001871,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0008150,GO:0009986,GO:0017076,GO:0030234,GO:0030246,GO:0030247,GO:0030554,GO:0036094,GO:0044464,GO:0050790,GO:0051082,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0097159,GO:0098772,GO:1901265,GO:1901363,GO:2001065	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
MMS3_k127_2733492_1	387631.Asulf_02087	4.474e-155	500.0	COG1257@1|root,arCOG04260@2157|Archaea,2XTV9@28890|Euryarchaeota,245ZK@183980|Archaeoglobi	183980|Archaeoglobi	I	Hydroxymethylglutaryl-CoA reductase, degradative	-	-	1.1.1.88	ko:K00054	ko00900,ko01110,ko01130,map00900,map01110,map01130	-	R02081	RC00004,RC00644	ko00000,ko00001,ko01000	-	-	-	HMG-CoA_red
MMS3_k127_2733492_9	1200792.AKYF01000003_gene193	1.966e-46	192.0	COG0311@1|root,COG0311@2|Bacteria,1V3I6@1239|Firmicutes,4HFSZ@91061|Bacilli,26SNW@186822|Paenibacillaceae	91061|Bacilli	H	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS	pdxT	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0032991,GO:0034641,GO:0042364,GO:0042802,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1902494,GO:1903600	4.3.3.6	ko:K08681	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SNO
MMS3_k127_2733492_7	192952.MM_1877	4.217e-50	193.0	COG1736@1|root,arCOG04112@2157|Archaea,2XSY5@28890|Euryarchaeota,2N9AT@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM Diphthamide synthesis DPH2 protein	dph2	-	2.5.1.108	ko:K07561	-	-	R10455	RC00021,RC03180	ko00000,ko01000,ko03012	-	-	-	Diphthamide_syn
MMS3_k127_2733492_22	1144275.COCOR_03729	5.186e-12	75.0	COG0321@1|root,COG0494@1|root,COG0321@2|Bacteria,COG0494@2|Bacteria,1MU6A@1224|Proteobacteria,42RIC@68525|delta/epsilon subdivisions,2WPRF@28221|Deltaproteobacteria,2YVCE@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate	lipB	-	2.3.1.181	ko:K03801	ko00785,ko01100,map00785,map01100	-	R07766,R07769	RC00039,RC00992,RC02867	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB,NUDIX
MMS3_k127_2733492_21	195522.BD01_1936	4.075e-13	82.0	COG1308@1|root,arCOG04061@2157|Archaea,2XXYV@28890|Euryarchaeota,244FN@183968|Thermococci	183968|Thermococci	J	Contacts the emerging nascent chain on the ribosome	nac	-	-	ko:K03626	-	-	-	-	ko00000	-	-	-	NAC
MMS3_k127_2733492_23	867845.KI911784_gene368	1.072e-10	74.0	COG0517@1|root,COG1993@1|root,COG3448@1|root,COG0517@2|Bacteria,COG1993@2|Bacteria,COG3448@2|Bacteria,2G69Z@200795|Chloroflexi,376P4@32061|Chloroflexia	32061|Chloroflexia	T	PFAM CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS,DUF190
MMS3_k127_2733492_19	224325.AF_0739	1.223e-16	86.0	COG0456@1|root,arCOG00833@2157|Archaea,2Y0G0@28890|Euryarchaeota,2469J@183980|Archaeoglobi	183980|Archaeoglobi	K	Ribosomal-protein-alanine acetyltransferase	-	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
MMS3_k127_2733492_16	439481.Aboo_0790	5.998e-31	133.0	COG1938@1|root,arCOG00347@2157|Archaea,2XT93@28890|Euryarchaeota,3F2T7@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	PAC2 family	-	-	-	ko:K06869	-	-	-	-	ko00000	-	-	-	PAC2
MMS3_k127_2733492_2	273116.14324743	1.649e-144	469.0	COG0451@1|root,arCOG04762@2157|Archaea,2XU8F@28890|Euryarchaeota,241XT@183967|Thermoplasmata	183967|Thermoplasmata	M	GDP-mannose 4,6 dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
MMS3_k127_2733492_13	368408.Tpen_1720	3.957e-35	152.0	COG1210@1|root,arCOG00665@2157|Archaea	2157|Archaea	M	PFAM Nucleotidyl transferase	galU	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
MMS3_k127_2733492_12	1122611.KB903979_gene3311	2.062e-38	164.0	COG0624@1|root,COG0624@2|Bacteria,2I8IJ@201174|Actinobacteria,4EMI3@85012|Streptosporangiales	201174|Actinobacteria	E	Peptidase family M28	argE	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
MMS3_k127_2733492_11	1961.JOAK01000009_gene6386	1.436e-38	160.0	COG0438@1|root,COG0438@2|Bacteria,2IBWR@201174|Actinobacteria	201174|Actinobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
MMS3_k127_2733492_14	471852.Tcur_0080	1.455e-33	145.0	COG0438@1|root,COG0438@2|Bacteria,2GJ57@201174|Actinobacteria,4EHVT@85012|Streptosporangiales	201174|Actinobacteria	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
MMS3_k127_2733492_4	1236689.MMALV_03620	5.53e-105	353.0	COG0436@1|root,arCOG01130@2157|Archaea,2XSVT@28890|Euryarchaeota,3F2HI@33867|unclassified Euryarchaeota	28890|Euryarchaeota	E	PFAM Aminotransferase class I and II	aspC2	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
MMS3_k127_2733492_5	518766.Rmar_1452	2.038e-100	360.0	COG0104@1|root,COG0104@2|Bacteria,4NGRZ@976|Bacteroidetes,1FJ5A@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
MMS3_k127_2733492_20	374847.Kcr_0550	1.814e-13	82.0	COG2431@1|root,arCOG01615@2157|Archaea	2157|Archaea	S	PFAM Membrane protein of	-	-	-	-	-	-	-	-	-	-	-	-	Lys_export
MMS3_k127_2733492_17	439481.Aboo_0391	1.189e-24	109.0	COG1518@1|root,arCOG01452@2157|Archaea,2XSVS@28890|Euryarchaeota	28890|Euryarchaeota	V	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette	-	-	-	ko:K15342	-	-	-	-	ko00000,ko02048,ko03400	-	-	-	Cas_Cas1
MMS3_k127_274391_3	224325.AF_0751	1.425e-25	109.0	COG1303@1|root,arCOG01857@2157|Archaea,2XV35@28890|Euryarchaeota,246QP@183980|Archaeoglobi	183980|Archaeoglobi	J	Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs	-	-	2.1.1.206	ko:K07254	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Trm56
MMS3_k127_274391_2	439481.Aboo_1323	3.459e-41	168.0	COG1577@1|root,arCOG01028@2157|Archaea,2XSUB@28890|Euryarchaeota,3F2JQ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	I	Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids	mvk	GO:0003674,GO:0003824,GO:0004496,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006084,GO:0006139,GO:0006163,GO:0006629,GO:0006637,GO:0006644,GO:0006720,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008202,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009117,GO:0009150,GO:0009240,GO:0009259,GO:0009987,GO:0016125,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019287,GO:0019637,GO:0019693,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046490,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901135,GO:1901360,GO:1901564,GO:1901576,GO:1901615	2.7.1.36	ko:K00869	ko00900,ko01100,ko01110,ko01130,ko04146,map00900,map01100,map01110,map01130,map04146	M00095	R02245	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg
MMS3_k127_274391_0	673860.AciM339_0508	3.656e-113	378.0	COG0012@1|root,arCOG00357@2157|Archaea,2XTZG@28890|Euryarchaeota,3F2GD@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	GTPase of unknown function C-terminal	ychF	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0044424,GO:0044464	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,MMR_HSR1_C,TGS
MMS3_k127_274391_1	357808.RoseRS_1980	9.05e-43	164.0	COG2096@1|root,COG2096@2|Bacteria,2G6TB@200795|Chloroflexi,3777D@32061|Chloroflexia	32061|Chloroflexia	S	PFAM cobalamin adenosyltransferase	-	-	2.5.1.17	ko:K00798	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	Cob_adeno_trans
MMS3_k127_274391_4	208444.JNYY01000001_gene4968	1.161e-20	96.0	COG2230@1|root,COG2230@2|Bacteria,2I82K@201174|Actinobacteria,4E4YH@85010|Pseudonocardiales	201174|Actinobacteria	M	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_12,Methyltransf_25,Methyltransf_31
MMS3_k127_2765541_0	1163730.FFONT_0906	2.266e-114	383.0	COG2235@1|root,arCOG03108@2157|Archaea,2XQ4B@28889|Crenarchaeota	28889|Crenarchaeota	E	Amidinotransferase	-	-	3.5.3.6	ko:K01478	ko00220,ko01100,ko01110,ko01130,map00220,map01100,map01110,map01130	-	R00552	RC00177	ko00000,ko00001,ko01000	-	-	-	Amidinotransf
MMS3_k127_2765541_10	1250278.JQNQ01000001_gene3320	3.942e-07	63.0	COG4867@1|root,COG4867@2|Bacteria,4NFMA@976|Bacteroidetes,1HWJG@117743|Flavobacteriia	976|Bacteroidetes	S	protein with a von Willebrand factor type A (vWA) domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA_2
MMS3_k127_2765541_8	1246448.ANAZ01000009_gene2697	8.699e-15	88.0	COG1239@1|root,COG1239@2|Bacteria,2GMRS@201174|Actinobacteria,4EGIC@85012|Streptosporangiales	201174|Actinobacteria	H	Sigma-54 interaction domain	chlI	-	6.6.1.1	ko:K03405	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03877	RC01012	ko00000,ko00001,ko01000	-	-	iNJ661.Rv0958	Mg_chelatase,Sigma54_activat
MMS3_k127_2765541_4	673860.AciM339_0403	1.428e-40	159.0	COG1890@1|root,arCOG04186@2157|Archaea,2XSX9@28890|Euryarchaeota,3F2MY@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Belongs to the eukaryotic ribosomal protein eS1 family	rps3ae	GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576	-	ko:K02984	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S3Ae
MMS3_k127_2765541_5	926560.KE387023_gene2224	3.183e-40	158.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	eryCVI	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0009058,GO:0009987,GO:0016740,GO:0016741,GO:0016999,GO:0017000,GO:0017144,GO:0032259,GO:0042802,GO:0042803,GO:0044237,GO:0044249,GO:0046983	2.1.1.234	ko:K13311,ko:K13326,ko:K21335	ko00523,ko01130,map00523,map01130	M00797,M00800	R06427,R11045,R11476	RC00003,RC01515,RC02262	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_25
MMS3_k127_2765541_13	396014.BF93_14960	0.0002194	53.0	COG4639@1|root,COG4639@2|Bacteria,2I64Y@201174|Actinobacteria,4FD9C@85020|Dermabacteraceae	201174|Actinobacteria	S	Zeta toxin	-	-	-	-	-	-	-	-	-	-	-	-	AAA_33
MMS3_k127_2765541_6	7668.SPU_021281.a-tr	4.274e-39	155.0	2CN6T@1|root,2QU8Z@2759|Eukaryota,3AJW4@33154|Opisthokonta,3BZXF@33208|Metazoa,3DG7J@33213|Bilateria	33208|Metazoa	S	YHYH protein	-	-	-	-	-	-	-	-	-	-	-	-	YHYH
MMS3_k127_2765541_7	399549.Msed_2031	2.276e-35	156.0	arCOG05891@1|root,arCOG05891@2157|Archaea	2157|Archaea	-	-	doxC	-	-	ko:K16934	-	-	-	-	ko00000	3.D.4.9	-	-	-
MMS3_k127_2765541_1	933801.Ahos_0034	1.871e-107	381.0	COG0843@1|root,arCOG01238@2157|Archaea,2XRQR@28889|Crenarchaeota	28889|Crenarchaeota	C	PFAM cytochrome c oxidase, subunit I	-	-	1.9.3.1	ko:K02274,ko:K16933	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
MMS3_k127_2765541_3	1210884.HG799462_gene8049	8.31e-79	277.0	COG1131@1|root,COG1131@2|Bacteria,2IZ5V@203682|Planctomycetes	203682|Planctomycetes	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
MMS3_k127_2765541_12	1047013.AQSP01000128_gene415	8.791e-07	62.0	COG1277@1|root,COG1277@2|Bacteria	2|Bacteria	-	-	nosY	-	-	ko:K01992,ko:K19341	ko02010,map02010	M00254,M00762	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.132.2	-	-	ABC2_membrane_2
MMS3_k127_2765541_2	575540.Isop_2113	1.199e-79	287.0	COG1131@1|root,COG1131@2|Bacteria,2IZF2@203682|Planctomycetes	203682|Planctomycetes	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
MMS3_k127_2765541_11	665577.JH993790_gene2234	8.171e-07	61.0	COG1277@1|root,COG1277@2|Bacteria,2GK3E@201174|Actinobacteria	201174|Actinobacteria	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_4
MMS3_k127_2765541_9	234267.Acid_4414	9.35e-08	64.0	COG1872@1|root,COG1872@2|Bacteria,3Y5S4@57723|Acidobacteria	57723|Acidobacteria	S	Belongs to the UPF0235 family	-	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
MMS3_k127_2774304_4	671143.DAMO_3151	3.346e-19	90.0	COG0177@1|root,COG0177@2|Bacteria,2NP8N@2323|unclassified Bacteria	2|Bacteria	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	GO:0000702,GO:0000703,GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006289,GO:0006296,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0033683,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360	3.1.11.2,4.2.99.18	ko:K01142,ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
MMS3_k127_2774304_0	521011.Mpal_1287	2.353e-186	612.0	COG0013@1|root,arCOG01255@2157|Archaea,2XSXB@28890|Euryarchaeota,2N92P@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
MMS3_k127_2774304_2	1094980.Mpsy_2342	6.246e-43	176.0	COG0467@1|root,arCOG01178@2157|Archaea,2Y0GM@28890|Euryarchaeota	28890|Euryarchaeota	T	PFAM GvpD gas vesicle	gvpD	-	-	-	-	-	-	-	-	-	-	-	GvpD
MMS3_k127_2774304_5	634497.HAH_3098	0.0001634	54.0	arCOG01881@1|root,arCOG01881@2157|Archaea,2XVW7@28890|Euryarchaeota,23TXZ@183963|Halobacteria	183963|Halobacteria	I	COG0170 Dolichol kinase	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_2774304_3	195522.BD01_1751	2.981e-40	157.0	COG0041@1|root,arCOG02464@2157|Archaea,2XU0P@28890|Euryarchaeota,24415@183968|Thermococci	183968|Thermococci	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
MMS3_k127_2774304_1	273075.Ta1361	1.815e-43	171.0	COG0519@1|root,arCOG00085@2157|Archaea,2XT82@28890|Euryarchaeota,241KI@183967|Thermoplasmata	183967|Thermoplasmata	F	Catalyzes the synthesis of GMP from XMP	guaAB	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GMP_synt_C,NAD_synthase
MMS3_k127_2842606_0	1173263.Syn7502_03148	2.289e-26	117.0	COG2013@1|root,COG2013@2|Bacteria	2|Bacteria	S	Mitochondrial biogenesis AIM24	-	-	-	-	-	-	-	-	-	-	-	-	AIM24
MMS3_k127_2842606_1	1158294.JOMI01000002_gene3142	2.407e-06	57.0	COG2013@1|root,COG2013@2|Bacteria,4NGXB@976|Bacteroidetes,2FX8K@200643|Bacteroidia	976|Bacteroidetes	S	Mitochondrial biogenesis AIM24	-	-	-	-	-	-	-	-	-	-	-	-	AIM24
MMS3_k127_2842606_2	634498.mru_0806	1.8e-05	56.0	COG2013@1|root,arCOG01907@2157|Archaea,2XW0I@28890|Euryarchaeota	28890|Euryarchaeota	S	Mitochondrial biogenesis AIM24	-	-	-	-	-	-	-	-	-	-	-	-	AIM24
MMS3_k127_2853665_3	673860.AciM339_0142	3.104e-23	102.0	COG0206@1|root,arCOG02201@2157|Archaea,2XTMW@28890|Euryarchaeota,3F32D@33867|unclassified Euryarchaeota	28890|Euryarchaeota	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ1	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
MMS3_k127_2853665_2	1125971.ASJB01000099_gene2288	2.981e-43	183.0	COG1131@1|root,COG1131@2|Bacteria,2IBJD@201174|Actinobacteria,4E1YQ@85010|Pseudonocardiales	201174|Actinobacteria	V	ABC-type multidrug transport system, ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
MMS3_k127_2853665_0	263820.PTO1253	2.587e-109	381.0	COG0348@1|root,arCOG03696@2157|Archaea	2157|Archaea	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_10
MMS3_k127_2853665_1	439481.Aboo_1172	3.873e-52	195.0	COG1933@1|root,arCOG04447@2157|Archaea,2XU5S@28890|Euryarchaeota,3F2HV@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase	polC	GO:0003674,GO:0005488,GO:0005515,GO:0042802	2.7.7.7	ko:K02322	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	M00264	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	Intein_splicing,LAGLIDADG_3,PolC_DP2
MMS3_k127_2866338_23	1041930.Mtc_0560	6.544e-07	61.0	arCOG02274@1|root,arCOG02274@2157|Archaea,2XWNK@28890|Euryarchaeota	28890|Euryarchaeota	K	DNA binding protein	-	-	-	ko:K06930	-	-	-	-	ko00000	-	-	-	HTH_10
MMS3_k127_2866338_5	1379698.RBG1_1C00001G0892	4.87e-100	341.0	COG1062@1|root,COG1062@2|Bacteria	2|Bacteria	C	S-(hydroxymethyl)glutathione dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N
MMS3_k127_2866338_10	1187851.A33M_3196	9.758e-75	267.0	COG1775@1|root,COG1775@2|Bacteria,1NNW9@1224|Proteobacteria,2U2IH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	benzoyl-CoA reductase	-	-	1.3.7.8	ko:K04112	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R02451	RC00002,RC01839	ko00000,ko00001,ko00002,ko01000	-	-	-	HGD-D
MMS3_k127_2866338_15	398767.Glov_2399	6.778e-51	201.0	COG1924@1|root,COG1924@2|Bacteria,1R6HU@1224|Proteobacteria,42RWX@68525|delta/epsilon subdivisions,2WNC9@28221|Deltaproteobacteria,43V8M@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	BadF/BadG/BcrA/BcrD ATPase family	yjiL	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG
MMS3_k127_2866338_11	477974.Daud_0885	3.871e-71	255.0	COG1924@1|root,COG1924@2|Bacteria,1TQSD@1239|Firmicutes,2481W@186801|Clostridia,261IU@186807|Peptococcaceae	186801|Clostridia	I	PFAM BadF BadG BcrA BcrD ATPase family	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG
MMS3_k127_2866338_8	258594.RPA0658	1.426e-92	319.0	COG1775@1|root,COG1775@2|Bacteria,1NKED@1224|Proteobacteria,2U31W@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	benzoyl-CoA reductase	-	-	1.3.7.8	ko:K04113	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R02451	RC00002,RC01839	ko00000,ko00001,ko00002,ko01000	-	-	-	HGD-D
MMS3_k127_2866338_4	1379698.RBG1_1C00001G0907	2.73e-105	365.0	COG1024@1|root,COG1024@2|Bacteria	2|Bacteria	I	Enoyl-CoA hydratase	bamA	GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009150,GO:0009154,GO:0009166,GO:0009259,GO:0009261,GO:0009987,GO:0016787,GO:0016822,GO:0016823,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0033865,GO:0033869,GO:0033875,GO:0034031,GO:0034032,GO:0034034,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035383,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044273,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901787,GO:1901788	3.7.1.21	ko:K07539,ko:K18570	ko00332,ko00362,ko01100,ko01120,ko01130,ko01220,map00332,map00362,map01100,map01120,map01130,map01220	M00541	R05593,R05594,R10696,R10750	RC01430,RC01431,RC03237,RC03270	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
MMS3_k127_2866338_13	675635.Psed_2676	1.474e-58	212.0	COG1024@1|root,COG1024@2|Bacteria,2GKJ6@201174|Actinobacteria,4E4WF@85010|Pseudonocardiales	201174|Actinobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	-	ko:K07546	ko00623,ko01100,ko01120,ko01220,map00623,map01100,map01120,map01220	M00418	R05599	RC01435	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
MMS3_k127_2866338_14	1380390.JIAT01000015_gene5734	2.264e-57	213.0	COG3511@1|root,COG3511@2|Bacteria	2|Bacteria	M	phospholipase C	-	-	3.1.4.3	ko:K01114	ko00562,ko00564,ko00565,ko01100,ko01110,ko02024,ko04919,map00562,map00564,map00565,map01100,map01110,map02024,map04919	-	R01312,R02027,R02052,R03332,R07381	RC00017,RC00425	ko00000,ko00001,ko01000,ko02042	-	-	-	Laminin_G_3,Phosphoesterase
MMS3_k127_2866338_22	296591.Bpro_2643	4.952e-10	65.0	COG3631@1|root,COG3631@2|Bacteria	2|Bacteria	S	light absorption	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
MMS3_k127_2866338_21	384765.SIAM614_08843	7.797e-11	72.0	COG2318@1|root,COG2318@2|Bacteria,1RI94@1224|Proteobacteria,2UANW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB
MMS3_k127_2866338_24	1173020.Cha6605_3528	1.304e-06	58.0	COG2318@1|root,COG2318@2|Bacteria,1G5EJ@1117|Cyanobacteria	1117|Cyanobacteria	S	PFAM DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB
MMS3_k127_2866338_18	644281.MFS40622_0311	5.159e-40	158.0	COG1056@1|root,arCOG00972@2157|Archaea,2XUF7@28890|Euryarchaeota,23QUJ@183939|Methanococci	183939|Methanococci	F	Nicotinamide-nucleotide adenylyltransferase	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.7.7.1	ko:K00952	ko00760,ko01100,map00760,map01100	-	R00137,R03005	RC00002	ko00000,ko00001,ko01000	-	-	-	CTP_transf_like
MMS3_k127_2866338_1	439481.Aboo_1408	7.781e-247	779.0	COG0466@1|root,arCOG02160@2157|Archaea,2XTT0@28890|Euryarchaeota,3F2HW@33867|unclassified Euryarchaeota	28890|Euryarchaeota	O	Belongs to the peptidase S16 family	lon	-	3.4.21.53	ko:K04076	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AAA_32,Lon_C,Mg_chelatase
MMS3_k127_2866338_16	1210045.ALNP01000008_gene4583	3.535e-50	191.0	COG0190@1|root,COG0190@2|Bacteria,2GJZS@201174|Actinobacteria	201174|Actinobacteria	H	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	-	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
MMS3_k127_2866338_9	673860.AciM339_0294	2.757e-77	273.0	COG2108@1|root,arCOG00932@2157|Archaea,2XU78@28890|Euryarchaeota,3F2FA@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	4Fe-4S single cluster domain	-	-	-	ko:K07129	-	-	-	-	ko00000	-	-	-	Fer4_14,Radical_SAM
MMS3_k127_2866338_17	1227487.C474_18705	1.956e-44	171.0	COG0638@1|root,arCOG00971@2157|Archaea,2XUKA@28890|Euryarchaeota,23T29@183963|Halobacteria	183963|Halobacteria	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	psmA	GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0019538,GO:0019773,GO:0030163,GO:0032991,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03432	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome,Proteasome_A_N
MMS3_k127_2866338_7	1121428.DESHY_110522___1	2.511e-94	339.0	COG0322@1|root,COG0322@2|Bacteria,1TP4B@1239|Firmicutes,247TQ@186801|Clostridia,260I5@186807|Peptococcaceae	186801|Clostridia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
MMS3_k127_2866338_0	292459.STH167	0.0	1061.0	COG0178@1|root,COG0178@2|Bacteria,1TPIJ@1239|Firmicutes,2485F@186801|Clostridia	186801|Clostridia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
MMS3_k127_2866338_19	673860.AciM339_0885	1.34e-38	153.0	COG1402@1|root,arCOG04536@2157|Archaea,2XTQE@28890|Euryarchaeota,3F335@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	Creatinine amidohydrolase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
MMS3_k127_2866338_3	439481.Aboo_0335	9.491e-180	596.0	COG0550@1|root,arCOG01305@1|root,arCOG01305@2157|Archaea,arCOG01527@2157|Archaea,2XU6T@28890|Euryarchaeota,3F2GF@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	HHH_5,Intein_splicing,Topoisom_bac,Toprim,zf-C4_Topoisom
MMS3_k127_2866338_20	1193181.BN10_1090009	1.396e-11	73.0	COG1695@1|root,COG1695@2|Bacteria,2IFDN@201174|Actinobacteria,4FH9N@85021|Intrasporangiaceae	201174|Actinobacteria	K	Transcriptional regulator PadR-like family	yqjI	-	-	-	-	-	-	-	-	-	-	-	PadR
MMS3_k127_2866338_6	999630.TUZN_0073	2.55e-96	334.0	COG1131@1|root,arCOG00194@2157|Archaea,2XPVP@28889|Crenarchaeota	28889|Crenarchaeota	V	TIGRFAM daunorubicin resistance ABC transporter ATPase subunit	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
MMS3_k127_2866338_12	399549.Msed_0251	6.383e-69	257.0	COG0842@1|root,arCOG01467@2157|Archaea,2XRP9@28889|Crenarchaeota	28889|Crenarchaeota	P	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
MMS3_k127_2866338_2	694429.Pyrfu_0975	6.324e-180	572.0	COG0365@1|root,arCOG01529@2157|Archaea,2XPY4@28889|Crenarchaeota	28889|Crenarchaeota	I	synthetase	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
MMS3_k127_2866613_3	84531.JMTZ01000009_gene3330	1.276e-53	197.0	COG0500@1|root,COG2226@2|Bacteria,1MW7J@1224|Proteobacteria,1T2EV@1236|Gammaproteobacteria,1XD5B@135614|Xanthomonadales	135614|Xanthomonadales	Q	O-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_2
MMS3_k127_2866613_12	63402.XP_003170030.1	0.0004093	49.0	KOG3178@1|root,KOG3178@2759|Eukaryota,39S0T@33154|Opisthokonta,3P1NK@4751|Fungi,3QR1T@4890|Ascomycota,20FAT@147545|Eurotiomycetes,3B5C9@33183|Onygenales,3FXS5@34384|Arthrodermataceae	4751|Fungi	S	O-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_2
MMS3_k127_2866613_8	1121378.KB899699_gene1790	1.173e-06	61.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
MMS3_k127_2866613_2	1459636.NTE_03247	1.65e-58	226.0	COG3608@1|root,arCOG02889@2157|Archaea	2157|Archaea	S	Succinylglutamate desuccinylase aspartoacylase	-	-	-	ko:K06987	-	-	-	-	ko00000	-	-	-	AstE_AspA,Peptidase_M14
MMS3_k127_2866613_0	1459636.NTE_03246	1.574e-147	488.0	COG1132@1|root,arCOG02841@2157|Archaea	2157|Archaea	V	COG1132 ABC-type multidrug transport system, ATPase and permease components	trp1	-	-	ko:K02068,ko:K06147,ko:K06148,ko:K11085	ko02010,map02010	M00211	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
MMS3_k127_2866613_1	1459636.NTE_03245	2.648e-104	355.0	arCOG14727@1|root,arCOG14727@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_2866613_6	673860.AciM339_0463	3.836e-12	74.0	COG3398@1|root,arCOG02611@2157|Archaea,2XWAQ@28890|Euryarchaeota,3F3BI@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_24,HTH_5
MMS3_k127_2866613_4	519442.Huta_2022	1.843e-36	151.0	COG0697@1|root,arCOG00271@2157|Archaea,2XTD0@28890|Euryarchaeota,23TNI@183963|Halobacteria	183963|Halobacteria	G	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
MMS3_k127_2866613_5	1116369.KB890026_gene5588	3.628e-33	133.0	COG3865@1|root,COG3865@2|Bacteria,1MZHY@1224|Proteobacteria,2UCHV@28211|Alphaproteobacteria,43M0E@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	3-demethylubiquinone-9 3-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	3-dmu-9_3-mt
MMS3_k127_2866613_7	935863.AWZR01000002_gene1031	2.686e-09	68.0	COG4973@1|root,COG4973@2|Bacteria,1MUJJ@1224|Proteobacteria,1RMJG@1236|Gammaproteobacteria,1X31C@135614|Xanthomonadales	135614|Xanthomonadales	L	Belongs to the 'phage' integrase family. XerC subfamily	xerC	-	-	ko:K03733	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
MMS3_k127_2866613_11	234267.Acid_0571	5.348e-05	53.0	COG0346@1|root,COG0346@2|Bacteria,3Y85T@57723|Acidobacteria	57723|Acidobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
MMS3_k127_2866613_9	572478.Vdis_0010	3.43e-06	59.0	COG3432@1|root,arCOG01055@2157|Archaea	2157|Archaea	K	Transcriptional regulator	-	-	-	ko:K11924	-	-	-	-	ko00000,ko03000	-	-	-	HTH_45
MMS3_k127_2927092_6	1284352.AOIG01000032_gene286	6.917e-24	119.0	COG0457@1|root,COG3210@1|root,COG5492@1|root,COG0457@2|Bacteria,COG3210@2|Bacteria,COG5492@2|Bacteria,1TR9M@1239|Firmicutes,4HEPP@91061|Bacilli,26T62@186822|Paenibacillaceae	91061|Bacilli	U	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,Cadherin-like,Cohesin,Invasin_D3,SLH
MMS3_k127_2927092_1	1047013.AQSP01000122_gene2224	1.99e-61	242.0	COG3291@1|root,COG5434@1|root,COG3291@2|Bacteria,COG5434@2|Bacteria,2NQ6Y@2323|unclassified Bacteria	2|Bacteria	M	PKD domain	-	-	3.2.1.157,3.2.1.91	ko:K19668,ko:K20850	ko00500,ko01100,ko02020,map00500,map01100,map02020	-	R02886,R11308	RC00799	ko00000,ko00001,ko01000	-	GH6,GH82	-	Beta_helix,CHU_C,Cadherin-like,FlgD_ig,PKD,Pectate_lyase_3
MMS3_k127_2927092_0	572546.Arcpr_0357	4.688e-104	346.0	COG1899@1|root,arCOG04142@2157|Archaea,2XSTD@28890|Euryarchaeota,2461M@183980|Archaeoglobi	183980|Archaeoglobi	H	Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue	dys	-	2.5.1.46	ko:K00809	-	-	-	-	ko00000,ko01000	-	-	-	DS
MMS3_k127_2927092_3	1227457.C451_14750	8.134e-50	190.0	COG3389@1|root,arCOG04463@2157|Archaea,2XSZT@28890|Euryarchaeota,23U5C@183963|Halobacteria	183963|Halobacteria	S	protein conserved in archaea	-	-	-	-	-	-	-	-	-	-	-	-	SPP
MMS3_k127_2927092_2	1054217.TALC_00385	4.85e-51	188.0	COG1601@1|root,COG3269@1|root,arCOG01640@2157|Archaea,arCOG01641@2157|Archaea,2XTVZ@28890|Euryarchaeota,241R9@183967|Thermoplasmata	183967|Thermoplasmata	J	eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA	eif2b	-	-	ko:K03238	ko03013,map03013	-	-	-	ko00000,ko00001,ko01009,ko03012	-	-	-	TRAM,eIF-5_eIF-2B
MMS3_k127_2927092_5	529709.PYCH_13920	4.989e-29	132.0	COG0560@1|root,arCOG01158@2157|Archaea,2XT0C@28890|Euryarchaeota,242US@183968|Thermococci	183968|Thermococci	E	phosphoserine phosphatase	-	-	3.1.3.3	ko:K01079	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R00582	RC00017	ko00000,ko00001,ko00002,ko01000,ko01009	-	-	-	HAD
MMS3_k127_2927092_4	368408.Tpen_1670	8.253e-43	167.0	COG0656@1|root,arCOG01618@2157|Archaea,2XPSJ@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
MMS3_k127_2933118_5	767817.Desgi_2448	2.159e-38	150.0	COG1832@1|root,COG1832@2|Bacteria,1V7C7@1239|Firmicutes,24N7A@186801|Clostridia,262C9@186807|Peptococcaceae	186801|Clostridia	S	PFAM CoA-binding domain protein	-	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
MMS3_k127_2933118_8	1356854.N007_10350	4.44e-09	68.0	COG1664@1|root,COG1664@2|Bacteria,1V6E6@1239|Firmicutes,4HHZU@91061|Bacilli	91061|Bacilli	M	COG1664 Integral membrane protein CcmA involved in cell shape determination	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
MMS3_k127_2933118_0	673860.AciM339_0894	9.29e-235	760.0	COG0060@1|root,arCOG00807@2157|Archaea,2XTIX@28890|Euryarchaeota,3F2FG@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
MMS3_k127_2933118_4	1343739.PAP_06535	1.442e-45	173.0	COG2078@1|root,arCOG01336@2157|Archaea,2XUAP@28890|Euryarchaeota,242T1@183968|Thermococci	183968|Thermococci	S	AMMECR1	-	-	-	ko:K09141	-	-	-	-	ko00000	-	-	-	AMMECR1
MMS3_k127_2933118_6	572546.Arcpr_0963	2.581e-12	72.0	COG1552@1|root,arCOG04049@2157|Archaea,2Y177@28890|Euryarchaeota	28890|Euryarchaeota	J	Belongs to the eukaryotic ribosomal protein eL40 family	rpl40e	-	-	ko:K02927	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L40e
MMS3_k127_2933118_3	673860.AciM339_0523	4.487e-62	241.0	COG0463@1|root,arCOG00894@2157|Archaea,2XUJ6@28890|Euryarchaeota,3F38U@33867|unclassified Euryarchaeota	28890|Euryarchaeota	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
MMS3_k127_2933118_7	1123508.JH636445_gene6786	8.475e-11	74.0	COG1371@1|root,COG1371@2|Bacteria,2J0RY@203682|Planctomycetes	203682|Planctomycetes	S	Archease protein family (MTH1598/TM1083)	-	-	-	-	-	-	-	-	-	-	-	-	Archease
MMS3_k127_2933118_1	565033.GACE_0640	1.738e-76	277.0	COG0075@1|root,arCOG00082@2157|Archaea,2XTWU@28890|Euryarchaeota,245V2@183980|Archaeoglobi	183980|Archaeoglobi	E	PFAM aminotransferase class V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
MMS3_k127_2933118_2	867903.ThesuDRAFT_02043	7.812e-76	265.0	COG1052@1|root,COG1052@2|Bacteria,1TPCX@1239|Firmicutes,25F0C@186801|Clostridia,3WD52@538999|Clostridiales incertae sedis	186801|Clostridia	CH	PFAM D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain	-	-	1.1.1.26,1.1.1.310,1.1.1.399,1.1.1.95	ko:K00015,ko:K00058,ko:K16843	ko00260,ko00270,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00020	R00717,R01388,R01513,R05693	RC00031,RC00042	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
MMS3_k127_2984352_3	1054217.TALC_00548	1.944e-19	90.0	COG0136@1|root,arCOG00494@2157|Archaea,2XTKH@28890|Euryarchaeota,241PK@183967|Thermoplasmata	183967|Thermoplasmata	E	Semialdehyde dehydrogenase, NAD binding domain	-	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
MMS3_k127_2984352_2	266117.Rxyl_1090	1.233e-34	151.0	COG0527@1|root,COG0527@2|Bacteria,2GN0G@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the aspartokinase family	-	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
MMS3_k127_2984352_4	78245.Xaut_1692	1.29e-14	88.0	COG0135@1|root,COG0135@2|Bacteria,1RA87@1224|Proteobacteria,2U7CH@28211|Alphaproteobacteria,3EZC9@335928|Xanthobacteraceae	28211|Alphaproteobacteria	E	N-(5'phosphoribosyl)anthranilate (PRA) isomerase	trpF	-	5.3.1.24	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03509	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	PRAI
MMS3_k127_2984352_0	1089544.KB912942_gene1185	2.302e-49	190.0	COG0428@1|root,COG0428@2|Bacteria,2IBHZ@201174|Actinobacteria,4E2MD@85010|Pseudonocardiales	201174|Actinobacteria	P	ZIP Zinc transporter	-	-	-	ko:K07238	-	-	-	-	ko00000,ko02000	2.A.5.5	-	-	Zip
MMS3_k127_2984352_1	1094980.Mpsy_0954	1.034e-47	182.0	COG1676@1|root,arCOG01701@2157|Archaea,2XTKB@28890|Euryarchaeota,2N92W@224756|Methanomicrobia	224756|Methanomicrobia	J	sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp	endA	-	4.6.1.16	ko:K01170	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_int_endo,tRNA_int_endo_N
MMS3_k127_2985934_0	1267533.KB906737_gene1564	8.122e-131	443.0	COG1331@1|root,COG1331@2|Bacteria,3Y3AA@57723|Acidobacteria,2JISJ@204432|Acidobacteriia	204432|Acidobacteriia	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	GlcNAc_2-epim,Thioredox_DsbH
MMS3_k127_2985934_9	1033806.HTIA_2646	4.264e-27	121.0	COG1407@1|root,arCOG01150@2157|Archaea,2XU3W@28890|Euryarchaeota,23SAT@183963|Halobacteria	183963|Halobacteria	S	ICC-like phosphoesterases	rpe	-	-	ko:K06953	-	-	-	-	ko00000	-	-	-	Metallophos,Metallophos_2
MMS3_k127_2985934_5	413816.BBJP01000005_gene262	2.332e-53	203.0	COG1395@1|root,arCOG04152@2157|Archaea,2XTMG@28890|Euryarchaeota,23SJQ@183963|Halobacteria	183963|Halobacteria	K	HTH-type transcriptional regulatory protein	-	-	-	ko:K07728	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3
MMS3_k127_2985934_11	263820.PTO0556	2e-07	64.0	arCOG07412@1|root,arCOG07412@2157|Archaea,2Y0S5@28890|Euryarchaeota,241XA@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_2985934_7	439481.Aboo_0937	6.23e-36	151.0	COG0237@1|root,arCOG01045@2157|Archaea,2XWNJ@28890|Euryarchaeota,3F2R1@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	AAA domain	coaE	-	-	-	-	-	-	-	-	-	-	iAF692.Mbar_A0975	AAA_17,RNA_binding
MMS3_k127_2985934_1	195522.BD01_0748	6.058e-83	313.0	COG0423@1|root,arCOG00405@2157|Archaea,2XSZK@28890|Euryarchaeota,242X6@183968|Thermococci	183968|Thermococci	J	Catalyzes the attachment of glycine to tRNA(Gly)	glyS	GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046983,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.14	ko:K01880	ko00970,map00970	M00359,M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	HGTP_anticodon,tRNA-synt_2b
MMS3_k127_2985934_6	351160.RCIX1426	1.407e-44	176.0	COG0402@1|root,arCOG00692@2157|Archaea,2XSYB@28890|Euryarchaeota,2N9II@224756|Methanomicrobia	224756|Methanomicrobia	F	PFAM amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	A_deaminase,Amidohydro_1
MMS3_k127_2985934_8	323259.Mhun_0077	2.755e-29	129.0	COG0524@1|root,arCOG00014@2157|Archaea,2XU7Z@28890|Euryarchaeota,2N9AW@224756|Methanomicrobia	224756|Methanomicrobia	G	Belongs to the carbohydrate kinase PfkB family	-	-	2.7.1.15,2.7.1.213,2.7.1.73	ko:K00852,ko:K22026	ko00030,ko00230,ko00240,map00030,map00230,map00240	-	R00513,R01051,R01131,R01228,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	iAF692.Mbar_A2903	PfkB
MMS3_k127_2985934_4	439481.Aboo_0289	3.101e-65	255.0	COG0303@1|root,arCOG00217@2157|Archaea,2XT2V@28890|Euryarchaeota,3F2ZG@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	TIGRFAM molybdenum cofactor synthesis domain	moeA2	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006464,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0018315,GO:0019538,GO:0019637,GO:0019693,GO:0019720,GO:0032324,GO:0034641,GO:0036211,GO:0042040,GO:0042278,GO:0043170,GO:0043412,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0061598,GO:0061599,GO:0070566,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657	2.10.1.1	ko:K03750,ko:K07219	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N,PBP_like
MMS3_k127_2985934_2	69014.TK2225	5.184e-68	259.0	COG2896@1|root,arCOG00930@2157|Archaea,2XT7P@28890|Euryarchaeota,242JX@183968|Thermococci	183968|Thermococci	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Mob_synth_C,Radical_SAM
MMS3_k127_2985934_3	1054217.TALC_00152	1.151e-67	243.0	COG0047@1|root,arCOG00102@2157|Archaea,2XTPA@28890|Euryarchaeota,241Q4@183967|Thermoplasmata	183967|Thermoplasmata	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purQ	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
MMS3_k127_2985934_10	590998.Celf_0876	2.906e-09	61.0	COG2890@1|root,COG2890@2|Bacteria,2GNC1@201174|Actinobacteria,4F21R@85016|Cellulomonadaceae	201174|Actinobacteria	J	Ribosomal protein L11 methyltransferase (PrmA)	-	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS
MMS3_k127_3005942_5	195522.BD01_0234	8.954e-70	244.0	COG0017@1|root,arCOG00406@2157|Archaea,2XTRE@28890|Euryarchaeota,242Q1@183968|Thermococci	183968|Thermococci	J	Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp)	aspS	-	6.1.1.12	ko:K22503	ko00970,map00970	M00359	R05577	RC00055,RC00523	ko00000,ko00001,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
MMS3_k127_3005942_1	673860.AciM339_1505	5.479e-172	563.0	COG1241@1|root,arCOG00439@2157|Archaea,2XT5D@28890|Euryarchaeota,3F2HN@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	MCM OB domain	mcm	-	-	ko:K10726	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	HTH_3,Intein_splicing,LAGLIDADG_3,MCM,MCM_N,MCM_OB
MMS3_k127_3005942_21	410358.Mlab_0925	8.338e-08	58.0	COG2412@1|root,arCOG04051@2157|Archaea,2XYQK@28890|Euryarchaeota,2N9YQ@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF424)	-	-	-	ko:K09148	-	-	-	-	ko00000	-	-	-	DUF424
MMS3_k127_3005942_16	572546.Arcpr_0696	2.275e-21	106.0	COG1499@1|root,arCOG04149@2157|Archaea,2XUAI@28890|Euryarchaeota,2464I@183980|Archaeoglobi	183980|Archaeoglobi	J	PFAM NMD3 family	-	-	-	ko:K07562	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko03009	-	-	-	NMD3
MMS3_k127_3005942_13	673860.AciM339_0306	4.338e-22	109.0	COG2450@1|root,arCOG02263@2157|Archaea,2XXYF@28890|Euryarchaeota,3F3BW@33867|unclassified Euryarchaeota	28890|Euryarchaeota	D	Pfam:DUF552	sepF	-	-	ko:K09152	-	-	-	-	ko00000	-	-	-	SepF
MMS3_k127_3005942_3	481448.Minf_2118	1.256e-92	327.0	COG0260@1|root,COG0260@2|Bacteria,46UWM@74201|Verrucomicrobia,37GDP@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepB	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
MMS3_k127_3005942_2	673860.AciM339_1197	1.584e-154	501.0	COG0433@1|root,arCOG00280@2157|Archaea,2Y7MA@28890|Euryarchaeota,3F30Q@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	AAA-like domain	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF87,HAS-barrel
MMS3_k127_3005942_9	673860.AciM339_1295	7.823e-41	163.0	COG1340@1|root,arCOG01159@2157|Archaea,2XU21@28890|Euryarchaeota,3F2P7@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	archaeal coiled-coil protein	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_3005942_22	246969.TAM4_588	1.333e-05	56.0	COG1011@1|root,arCOG02291@2157|Archaea,2XUJR@28890|Euryarchaeota,2431M@183968|Thermococci	183968|Thermococci	S	haloacid dehalogenase-like hydrolase	-	-	3.8.1.2	ko:K01560,ko:K07025	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05287	RC00697	ko00000,ko00001,ko01000	-	-	-	HAD_2
MMS3_k127_3005942_14	439481.Aboo_0215	5.019e-22	104.0	COG1719@1|root,arCOG01688@2157|Archaea	2157|Archaea	K	PFAM 4-vinyl reductase, 4VR	-	-	-	ko:K07013	-	-	-	-	ko00000	-	-	-	DUF2507,V4R
MMS3_k127_3005942_15	693661.Arcve_1632	1.048e-21	98.0	COG2018@1|root,arCOG02603@2157|Archaea,2XY6Z@28890|Euryarchaeota	28890|Euryarchaeota	S	Roadblock LC7 family protein	-	-	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
MMS3_k127_3005942_4	439481.Aboo_0519	6.965e-75	261.0	COG0463@1|root,arCOG01385@2157|Archaea,2XUEP@28890|Euryarchaeota,3F30S@33867|unclassified Euryarchaeota	28890|Euryarchaeota	M	PFAM Glycosyl transferase family 2	aglI	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
MMS3_k127_3005942_12	673860.AciM339_1207	6.944e-25	106.0	COG1873@1|root,arCOG02155@2157|Archaea,2Y75G@28890|Euryarchaeota,3F3FD@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	PRC-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	PRC
MMS3_k127_3005942_17	565033.GACE_1607	2.283e-21	98.0	COG1727@1|root,arCOG00780@2157|Archaea,2XZ6R@28890|Euryarchaeota,246C1@183980|Archaeoglobi	183980|Archaeoglobi	J	Belongs to the eukaryotic ribosomal protein eL18 family	rpl18e	-	-	ko:K02883	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18,Ribosomal_L27A
MMS3_k127_3005942_11	673860.AciM339_1029	1.193e-31	134.0	COG0102@1|root,arCOG04242@2157|Archaea,2XWN6@28890|Euryarchaeota,3F2SC@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rpl13	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
MMS3_k127_3005942_10	589924.Ferp_1963	4.379e-37	153.0	COG0088@1|root,arCOG04243@2157|Archaea,2XWK0@28890|Euryarchaeota,2471N@183980|Archaeoglobi	183980|Archaeoglobi	J	Belongs to the universal ribosomal protein uS9 family	rps9	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
MMS3_k127_3005942_18	1227457.C451_16925	3.285e-20	96.0	COG1644@1|root,arCOG04244@2157|Archaea,2Y03I@28890|Euryarchaeota,23WQQ@183963|Halobacteria	183963|Halobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoN	-	2.7.7.6	ko:K03058	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_N
MMS3_k127_3005942_23	1121011.AUCB01000008_gene1240	0.0002277	55.0	COG3055@1|root,COG3291@1|root,COG3055@2|Bacteria,COG3291@2|Bacteria,4NHHD@976|Bacteroidetes,1HZ82@117743|Flavobacteriia	976|Bacteroidetes	G	Kelch	-	-	-	-	-	-	-	-	-	-	-	-	He_PIG,Kelch_1,Kelch_3,Kelch_4,Kelch_6,Malectin,PKD
MMS3_k127_3005942_0	439481.Aboo_1075	1.221e-238	747.0	COG0464@1|root,arCOG01308@2157|Archaea,2XSYR@28890|Euryarchaeota,3F2FM@33867|unclassified Euryarchaeota	28890|Euryarchaeota	O	Cell division protein 48 (CDC48), domain 2	cdc48a	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N
MMS3_k127_3005942_7	673860.AciM339_1208	3.041e-53	194.0	COG0464@1|root,arCOG01308@2157|Archaea,2XSYR@28890|Euryarchaeota,3F2FM@33867|unclassified Euryarchaeota	28890|Euryarchaeota	O	Cell division protein 48 (CDC48), domain 2	cdc48a	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N
MMS3_k127_3005942_8	42256.RradSPS_1156	4.685e-45	179.0	COG1801@1|root,COG1801@2|Bacteria,2GMSP@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
MMS3_k127_3005942_19	439481.Aboo_0014	1.347e-14	86.0	arCOG02780@1|root,arCOG02780@2157|Archaea,2Y714@28890|Euryarchaeota,3F34G@33867|unclassified Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_3005942_6	1459636.NTE_01556	4.181e-58	212.0	arCOG00517@1|root,arCOG00517@2157|Archaea,41SHJ@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
MMS3_k127_3005942_20	1197130.BAFM01000009_gene1750	3.286e-09	67.0	COG1617@1|root,arCOG02197@2157|Archaea,2XXRY@28890|Euryarchaeota,23W8H@183963|Halobacteria	183963|Halobacteria	S	KEOPS complex Cgi121-like subunit	cgi121	-	-	ko:K09119	-	-	-	-	ko00000,ko03016	-	-	-	CGI-121
MMS3_k127_3029838_11	386456.JQKN01000008_gene1391	2.918e-25	121.0	COG0419@1|root,arCOG00368@2157|Archaea,2XTC7@28890|Euryarchaeota	28890|Euryarchaeota	L	Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50 Mre11 complex	rad50	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K03546	-	-	-	-	ko00000,ko03400	-	-	-	AAA_15,AAA_21,AAA_23,Rad50_zn_hook,SMC_N
MMS3_k127_3029838_4	436308.Nmar_0937	3.854e-84	291.0	COG0667@1|root,arCOG01623@2157|Archaea,41SA6@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
MMS3_k127_3029838_6	861299.J421_0848	8.211e-79	286.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	1.21.98.3	ko:K04034	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R06268,R06269,R06270	RC00741,RC01491,RC01492	ko00000,ko00001,ko01000	-	-	-	B12-binding,Radical_SAM
MMS3_k127_3029838_15	1173020.Cha6605_3693	2.409e-10	63.0	COG1135@1|root,COG1145@1|root,COG1135@2|Bacteria,COG1145@2|Bacteria,1G5Q2@1117|Cyanobacteria	1117|Cyanobacteria	C	NIL domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,NIL
MMS3_k127_3029838_10	525904.Tter_1695	2.202e-32	135.0	COG0822@1|root,COG0822@2|Bacteria,2NPXN@2323|unclassified Bacteria	2|Bacteria	C	NifU-like N terminal domain	nifU	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
MMS3_k127_3029838_9	1131266.ARWQ01000005_gene810	1.565e-44	180.0	COG0719@1|root,arCOG01715@2157|Archaea,41S7W@651137|Thaumarchaeota	651137|Thaumarchaeota	O	FeS assembly protein SufD	-	-	-	ko:K09014,ko:K09015	-	-	-	-	ko00000	-	-	-	UPF0051
MMS3_k127_3029838_0	1459636.NTE_02649	4.825e-206	651.0	COG0719@1|root,arCOG01715@2157|Archaea,41S5W@651137|Thaumarchaeota	651137|Thaumarchaeota	O	FeS assembly protein SufB	-	-	-	ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
MMS3_k127_3029838_2	324602.Caur_3483	3.744e-134	452.0	COG0520@1|root,COG0520@2|Bacteria,2G5T3@200795|Chloroflexi,3766K@32061|Chloroflexia	32061|Chloroflexia	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	-	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
MMS3_k127_3029838_5	935839.JAGJ01000003_gene1361	6.903e-81	277.0	COG0396@1|root,COG0396@2|Bacteria,2GKB7@201174|Actinobacteria,4F410@85017|Promicromonosporaceae	201174|Actinobacteria	O	ATPases associated with a variety of cellular activities	sufC	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
MMS3_k127_3029838_14	985665.HPL003_16805	1.611e-13	84.0	COG2345@1|root,COG2345@2|Bacteria,1V3GF@1239|Firmicutes,4HG9G@91061|Bacilli,275GJ@186822|Paenibacillaceae	91061|Bacilli	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_11,HTH_20
MMS3_k127_3029838_12	608538.HTH_0588	2.747e-20	98.0	COG1310@1|root,COG1310@2|Bacteria,2G540@200783|Aquificae	200783|Aquificae	S	Mov34 MPN PAD-1 family protein	-	-	-	-	-	-	-	-	-	-	-	-	Prok-JAB
MMS3_k127_3029838_3	1303518.CCALI_00532	4.023e-130	444.0	COG0476@1|root,COG0607@1|root,COG1977@1|root,COG0476@2|Bacteria,COG0607@2|Bacteria,COG1977@2|Bacteria	2|Bacteria	H	Mo-molybdopterin cofactor metabolic process	moeB	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006732,GO:0006777,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008146,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009108,GO:0009605,GO:0009607,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0016782,GO:0018130,GO:0019344,GO:0019538,GO:0019637,GO:0019720,GO:0019752,GO:0020012,GO:0030312,GO:0030682,GO:0042783,GO:0043170,GO:0043207,GO:0043436,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0051189,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051810,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0061605,GO:0070566,GO:0071704,GO:0071944,GO:0075136,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.7.73,2.7.7.80,2.8.1.11	ko:K03148,ko:K03636,ko:K21029,ko:K21147	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07459,R07461	RC00043	ko00000,ko00001,ko01000	-	-	-	Rhodanese,ThiF,ThiS
MMS3_k127_3029838_1	673860.AciM339_0648	1.232e-173	565.0	COG1245@1|root,arCOG00187@2157|Archaea,2XSZE@28890|Euryarchaeota,3F2G2@33867|unclassified Euryarchaeota	28890|Euryarchaeota	E	metal-binding domain in RNase L inhibitor, RLI	rli	GO:0000166,GO:0003674,GO:0005488,GO:0005506,GO:0005524,GO:0006412,GO:0006413,GO:0006415,GO:0006518,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0017076,GO:0019538,GO:0022411,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032984,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0043021,GO:0043024,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044877,GO:0046872,GO:0046914,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K06174	-	-	-	-	ko00000,ko03009	-	-	-	ABC_tran,Fer4,RLI
MMS3_k127_3029838_8	997346.HMPREF9374_1550	1.721e-55	217.0	COG1136@1|root,COG1136@2|Bacteria,1TPBJ@1239|Firmicutes,4HBMF@91061|Bacilli,27CS7@186824|Thermoactinomycetaceae	91061|Bacilli	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
MMS3_k127_3029838_16	662479.C440_04363	2.03e-08	68.0	COG0577@1|root,arCOG02312@2157|Archaea,2XSXF@28890|Euryarchaeota,23SHH@183963|Halobacteria	183963|Halobacteria	V	ABC-type antimicrobial peptide transport system, permease component	lolE	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
MMS3_k127_3029838_13	662479.C440_04363	8.816e-19	102.0	COG0577@1|root,arCOG02312@2157|Archaea,2XSXF@28890|Euryarchaeota,23SHH@183963|Halobacteria	183963|Halobacteria	V	ABC-type antimicrobial peptide transport system, permease component	lolE	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
MMS3_k127_3029838_7	439481.Aboo_0781	4.685e-61	222.0	COG1469@1|root,arCOG04301@2157|Archaea,2XT11@28890|Euryarchaeota,3F2JX@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin	mptA	GO:0003674,GO:0003824,GO:0003933,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044682	3.5.4.39	ko:K17488	ko00790,map00790	-	R10348	RC02504,RC03131	ko00000,ko00001,ko01000	-	-	-	GCHY-1
MMS3_k127_3029838_17	1449076.JOOE01000003_gene3207	1.741e-06	53.0	COG2151@1|root,COG2151@2|Bacteria,1MZ9Y@1224|Proteobacteria,2U72U@28211|Alphaproteobacteria,2K4IC@204457|Sphingomonadales	204457|Sphingomonadales	S	FeS assembly SUF system protein	-	-	-	-	-	-	-	-	-	-	-	-	FeS_assembly_P
MMS3_k127_3031551_3	1340434.AXVA01000010_gene5473	6.267e-06	57.0	COG2318@1|root,COG2318@2|Bacteria,1V38X@1239|Firmicutes,4HGQ4@91061|Bacilli,1ZHN6@1386|Bacillus	91061|Bacilli	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB
MMS3_k127_3031551_4	1894.JOER01000025_gene6961	0.0001312	55.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
MMS3_k127_3031551_1	1448860.BBJO01000014_gene1427	2.85e-09	70.0	arCOG02274@1|root,arCOG02274@2157|Archaea,2XVHG@28890|Euryarchaeota,23SZN@183963|Halobacteria	183963|Halobacteria	K	DNA binding protein	-	-	-	ko:K06930	-	-	-	-	ko00000	-	-	-	HTH_10
MMS3_k127_3031551_0	42256.RradSPS_2321	1.401e-16	91.0	COG4122@1|root,COG4122@2|Bacteria,2IR7F@201174|Actinobacteria	201174|Actinobacteria	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_24
MMS3_k127_3031551_2	9031.ENSGALP00000011462	9.166e-07	57.0	COG2453@1|root,KOG1716@2759|Eukaryota,38DF8@33154|Opisthokonta,3BE7W@33208|Metazoa,3CSN0@33213|Bilateria,4825F@7711|Chordata,493DQ@7742|Vertebrata,4GQNB@8782|Aves	33208|Metazoa	V	dual specificity	DUSP12	GO:0001932,GO:0001933,GO:0003674,GO:0003824,GO:0004721,GO:0004725,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0006109,GO:0006464,GO:0006469,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008138,GO:0008150,GO:0008152,GO:0008270,GO:0009892,GO:0009893,GO:0009966,GO:0009968,GO:0009987,GO:0010562,GO:0010563,GO:0010605,GO:0010646,GO:0010648,GO:0010675,GO:0010676,GO:0010906,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019220,GO:0019222,GO:0019538,GO:0019899,GO:0019900,GO:0023051,GO:0023057,GO:0031323,GO:0031324,GO:0031325,GO:0031399,GO:0031400,GO:0032268,GO:0032269,GO:0032872,GO:0032873,GO:0033131,GO:0033133,GO:0033673,GO:0033674,GO:0035335,GO:0036211,GO:0042325,GO:0042326,GO:0042327,GO:0042578,GO:0043085,GO:0043086,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043405,GO:0043407,GO:0043408,GO:0043409,GO:0043412,GO:0043506,GO:0043508,GO:0043549,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0045859,GO:0045913,GO:0045936,GO:0045937,GO:0046328,GO:0046329,GO:0046872,GO:0046914,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048585,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051174,GO:0051246,GO:0051248,GO:0051338,GO:0051347,GO:0051348,GO:0060255,GO:0062012,GO:0065007,GO:0065009,GO:0070302,GO:0070303,GO:0071704,GO:0071900,GO:0071901,GO:0080090,GO:0080134,GO:0080135,GO:0140096,GO:1901564,GO:1902531,GO:1902532,GO:1903299,GO:1903301	3.1.3.16,3.1.3.48	ko:K14819	-	-	-	-	ko00000,ko01000,ko01009,ko03009	-	-	-	DSPc
MMS3_k127_3053330_3	264462.Bd3432	8.779e-05	49.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2MSND@213481|Bdellovibrionales,2WIT0@28221|Deltaproteobacteria	213481|Bdellovibrionales	T	two component, sigma54 specific, transcriptional regulator, Fis family	fgrM	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
MMS3_k127_3053330_2	1163409.UUA_01809	3.991e-86	301.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,1RQX2@1236|Gammaproteobacteria,1X3SQ@135614|Xanthomonadales	135614|Xanthomonadales	C	FAD FMN-containing dehydrogenases	dld	-	1.1.2.4,1.1.5.12	ko:K00102,ko:K03777	ko00620,ko01120,map00620,map01120	-	R00197,R00704,R11591	RC00044	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
MMS3_k127_3053330_1	518766.Rmar_1923	1.834e-87	302.0	COG0494@1|root,COG1194@1|root,COG0494@2|Bacteria,COG1194@2|Bacteria,4NDZY@976|Bacteroidetes,1FISB@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	L	NUDIX domain	mutY	-	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD,NUDIX_4
MMS3_k127_3053330_0	479434.Sthe_1572	9.011e-116	391.0	COG0138@1|root,COG0138@2|Bacteria,2G5JG@200795|Chloroflexi,27XK9@189775|Thermomicrobia	189775|Thermomicrobia	F	AICARFT/IMPCHase bienzyme	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
MMS3_k127_311902_3	273063.STK_15180	2.925e-23	105.0	COG0109@1|root,arCOG00479@2157|Archaea,2XQH8@28889|Crenarchaeota	28889|Crenarchaeota	H	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	ctaB	GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
MMS3_k127_311902_1	1120919.AUBI01000008_gene347	3.932e-50	188.0	COG0293@1|root,COG0293@2|Bacteria,1MW1C@1224|Proteobacteria,2TSBW@28211|Alphaproteobacteria,2JPI0@204441|Rhodospirillales	204441|Rhodospirillales	J	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit	ftsJ	-	2.1.1.166	ko:K02427	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ
MMS3_k127_311902_2	634497.HAH_2726	9.54e-38	158.0	COG2518@1|root,arCOG00976@2157|Archaea,2XTRM@28890|Euryarchaeota,23TBT@183963|Halobacteria	183963|Halobacteria	O	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
MMS3_k127_311902_0	673860.AciM339_0397	2.589e-69	256.0	COG0648@1|root,arCOG01894@2157|Archaea,2XU62@28890|Euryarchaeota,3F2J1@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Xylose isomerase-like TIM barrel	-	-	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
MMS3_k127_3139832_2	1051632.TPY_3048	3.392e-15	87.0	arCOG07408@1|root,2ZWPP@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_3139832_0	1227484.C471_00190	1.614e-153	505.0	COG2759@1|root,arCOG04541@2157|Archaea,2XUXB@28890|Euryarchaeota,23RXR@183963|Halobacteria	183963|Halobacteria	F	Belongs to the formate--tetrahydrofolate ligase family	fhs	-	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
MMS3_k127_3139832_3	370438.PTH_0934	1.664e-12	72.0	COG1236@1|root,COG1236@2|Bacteria,1UPPD@1239|Firmicutes,25HKE@186801|Clostridia,263Z3@186807|Peptococcaceae	186801|Clostridia	L	Metallo-beta-lactamase superfamily	-	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	-
MMS3_k127_3145653_0	1054217.TALC_00697	4.249e-114	378.0	COG0112@1|root,arCOG00070@2157|Archaea,2XU0H@28890|Euryarchaeota,241JA@183967|Thermoplasmata	183967|Thermoplasmata	E	Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
MMS3_k127_3145653_7	1111479.AXAR01000001_gene377	2.129e-11	70.0	COG0824@1|root,COG0824@2|Bacteria,1V6GS@1239|Firmicutes,4HJ05@91061|Bacilli,278KI@186823|Alicyclobacillaceae	91061|Bacilli	S	Thioesterase-like superfamily	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT_2
MMS3_k127_3145653_8	439481.Aboo_0034	4.991e-08	64.0	arCOG00828@1|root,arCOG00828@2157|Archaea,2Y6YR@28890|Euryarchaeota,3F2XN@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_3145653_2	439481.Aboo_0654	1.506e-77	287.0	arCOG00373@1|root,arCOG02452@1|root,arCOG00373@2157|Archaea,arCOG02452@2157|Archaea,2Y71H@28890|Euryarchaeota,3F35U@33867|unclassified Euryarchaeota	28890|Euryarchaeota	T	Pfam:KaiC	-	-	-	-	-	-	-	-	-	-	-	-	ATPase
MMS3_k127_3145653_1	1054217.TALC_00320	7.161e-96	325.0	COG0162@1|root,arCOG01886@2157|Archaea,2XTA0@28890|Euryarchaeota,241NP@183967|Thermoplasmata	183967|Thermoplasmata	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	tRNA-synt_1b
MMS3_k127_3145653_4	186497.PF1367	2.372e-40	152.0	COG1358@1|root,arCOG01751@2157|Archaea,2XX4C@28890|Euryarchaeota,2444W@183968|Thermococci	183968|Thermococci	J	Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H ACA, box C D and box C' D' sRNAs	rpl7ae	GO:0000470,GO:0000966,GO:0001682,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034471,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02936	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03009,ko03011	-	-	-	Ribosomal_L7Ae
MMS3_k127_3145653_5	263820.PTO1281	7.093e-23	106.0	COG2053@1|root,arCOG04314@2157|Archaea,2XYMV@28890|Euryarchaeota,241VA@183967|Thermoplasmata	183967|Thermoplasmata	J	Belongs to the eukaryotic ribosomal protein eS28 family	rps28e	-	-	ko:K02979	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S28e
MMS3_k127_3145653_6	273075.Ta1114	1.042e-14	80.0	COG2075@1|root,arCOG01950@2157|Archaea,2Y00Q@28890|Euryarchaeota,241X3@183967|Thermoplasmata	183967|Thermoplasmata	J	Binds to the 23S rRNA	rpl24e	-	-	ko:K02896	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L24e
MMS3_k127_3145653_3	416348.Hlac_3616	1.381e-71	260.0	COG5659@1|root,arCOG07789@2157|Archaea,2Y4ED@28890|Euryarchaeota	28890|Euryarchaeota	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
MMS3_k127_3145690_0	1536772.R70723_08390	2.328e-40	164.0	COG0491@1|root,COG0491@2|Bacteria,1V8JE@1239|Firmicutes,4HIYW@91061|Bacilli,26VD8@186822|Paenibacillaceae	91061|Bacilli	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
MMS3_k127_3145690_2	1452535.JARD01000018_gene2667	4.306e-06	55.0	COG0346@1|root,COG0346@2|Bacteria,2IKTR@201174|Actinobacteria,4FPV1@85023|Microbacteriaceae	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
MMS3_k127_3145690_1	926560.KE387025_gene4044	1.397e-39	160.0	2C1EG@1|root,2Z7MZ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_3145690_3	1297617.JPJD01000006_gene261	4.144e-05	52.0	COG0346@1|root,COG0346@2|Bacteria,1V6K3@1239|Firmicutes,24J94@186801|Clostridia,2694E@186813|unclassified Clostridiales	186801|Clostridia	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	gloA	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
MMS3_k127_3145772_2	1261545.MBE-HAL_1452	1.718e-22	109.0	COG3425@1|root,arCOG01767@2157|Archaea,2XTWE@28890|Euryarchaeota,23TJ1@183963|Halobacteria	183963|Halobacteria	I	COG3425 3-hydroxy-3-methylglutaryl CoA synthase	acaA	-	2.3.3.10	ko:K01641,ko:K07068	ko00072,ko00280,ko00650,ko00900,ko01100,ko01110,ko01130,map00072,map00280,map00650,map00900,map01100,map01110,map01130	M00088,M00095	R01978	RC00004,RC00503	ko00000,ko00001,ko00002,ko01000	-	-	-	ACP_syn_III_C,DUF35_N,OB_aCoA_assoc
MMS3_k127_3145772_1	383372.Rcas_3184	3.828e-124	419.0	COG3975@1|root,COG3975@2|Bacteria,2GAB7@200795|Chloroflexi,374W2@32061|Chloroflexia	32061|Chloroflexia	S	SMART PDZ DHR GLGF domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Peptidase_M61
MMS3_k127_3145772_0	439481.Aboo_0580	1.114e-141	469.0	COG1964@1|root,arCOG00933@2157|Archaea,2XTMK@28890|Euryarchaeota,3F2FE@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	4Fe-4S single cluster domain	-	-	-	ko:K06937	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Fer4_14,Intein_splicing,LAGLIDADG_3,Radical_SAM
MMS3_k127_315449_1	273063.STK_10340	8.688e-63	227.0	COG1131@1|root,arCOG00194@2157|Archaea	2157|Archaea	V	ABC-type multidrug transport system ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
MMS3_k127_315449_2	1304872.JAGC01000009_gene249	1.558e-20	98.0	COG3448@1|root,COG3448@2|Bacteria,1Q1A8@1224|Proteobacteria,42SIQ@68525|delta/epsilon subdivisions,2WPF0@28221|Deltaproteobacteria,2MBHS@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
MMS3_k127_315449_0	452637.Oter_1810	1.622e-202	653.0	COG3590@1|root,COG3590@2|Bacteria,46UUX@74201|Verrucomicrobia	2|Bacteria	O	Peptidase family M13	-	-	-	ko:K07386	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M13,Peptidase_M13_N
MMS3_k127_315449_3	105420.BBPO01000001_gene122	1.172e-07	58.0	COG0454@1|root,COG0456@2|Bacteria,2GQGN@201174|Actinobacteria,2NIBI@228398|Streptacidiphilus	201174|Actinobacteria	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
MMS3_k127_3197091_2	1198114.AciX9_2489	4.606e-22	112.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	wcoG	-	-	-	-	-	-	-	-	-	-	-	DUF5122,Laminin_G_3,PKD
MMS3_k127_3197091_0	33898.JRHJ01000098_gene6216	1.561e-41	169.0	COG0500@1|root,COG0500@2|Bacteria	2|Bacteria	Q	methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31
MMS3_k127_3197091_1	1187851.A33M_3786	3.538e-22	104.0	COG0517@1|root,COG0517@2|Bacteria,1NY5H@1224|Proteobacteria,2U1GG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	CBS domain	MA20_38110	-	-	-	-	-	-	-	-	-	-	-	BON,CBS
MMS3_k127_3197091_3	405948.SACE_3751	2.371e-07	57.0	COG3797@1|root,COG3797@2|Bacteria,2GPDB@201174|Actinobacteria,4E66I@85010|Pseudonocardiales	201174|Actinobacteria	S	Protein of unknown function (DUF1697)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1697
MMS3_k127_3216740_1	700598.Niako_1679	1.344e-26	120.0	2CJRS@1|root,347EE@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_3216740_0	644966.Tmar_0462	6.177e-85	299.0	COG0038@1|root,COG0517@1|root,COG0038@2|Bacteria,COG0517@2|Bacteria,1TPX0@1239|Firmicutes,247R4@186801|Clostridia,3WDH0@538999|Clostridiales incertae sedis	186801|Clostridia	P	Voltage gated chloride channel	-	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	-	CBS,Voltage_CLC
MMS3_k127_3216740_4	1137799.GZ78_23640	0.0007058	50.0	COG0346@1|root,COG0346@2|Bacteria,1RJZZ@1224|Proteobacteria,1S792@1236|Gammaproteobacteria,1XJZ0@135619|Oceanospirillales	135619|Oceanospirillales	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
MMS3_k127_3216740_2	323259.Mhun_2493	1.387e-18	100.0	COG0526@1|root,arCOG01972@2157|Archaea,2XXRJ@28890|Euryarchaeota,2N9YG@224756|Methanomicrobia	224756|Methanomicrobia	O	Thioredoxin	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
MMS3_k127_3216740_3	1293047.CBMA010000047_gene2864	0.0005985	51.0	COG3413@1|root,arCOG02271@2157|Archaea,2XX04@28890|Euryarchaeota,23VCD@183963|Halobacteria	183963|Halobacteria	K	Bacterio-opsin activator HTH domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_10
MMS3_k127_3220776_3	673860.AciM339_0947	0.0005888	47.0	COG1041@1|root,arCOG00047@2157|Archaea,2XTD6@28890|Euryarchaeota,3F2QX@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Pfam:Methyltransf_26	trmG10	GO:0000049,GO:0001510,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004809,GO:0005488,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0140098,GO:0140101,GO:1901360,GO:1901363	2.1.1.213	ko:K07446	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	THUMP,UPF0020
MMS3_k127_3220776_0	673860.AciM339_1060	2.123e-90	318.0	COG0750@1|root,arCOG00609@2157|Archaea,2XT29@28890|Euryarchaeota,3F2WK@33867|unclassified Euryarchaeota	28890|Euryarchaeota	M	Peptidase family M50	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
MMS3_k127_3220776_2	589924.Ferp_0985	1.554e-14	79.0	COG4004@1|root,arCOG04412@2157|Archaea,2Y1TD@28890|Euryarchaeota,246DU@183980|Archaeoglobi	183980|Archaeoglobi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_3220776_1	673860.AciM339_0628	1.997e-15	82.0	arCOG05238@1|root,arCOG05238@2157|Archaea,2Y0YG@28890|Euryarchaeota,3F3EA@33867|unclassified Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_3229872_11	1236689.MMALV_14190	5.268e-12	69.0	COG0255@1|root,arCOG00785@2157|Archaea,2Y1DQ@28890|Euryarchaeota,3F2VT@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Ribosomal L29 protein	rpl29	-	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
MMS3_k127_3229872_7	439481.Aboo_1512	3.027e-32	133.0	COG0186@1|root,arCOG04096@2157|Archaea,2XYPE@28890|Euryarchaeota,3F2Q9@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rps17	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
MMS3_k127_3229872_0	673860.AciM339_1108	2.872e-48	184.0	COG0093@1|root,arCOG04095@2157|Archaea,2XWM6@28890|Euryarchaeota,3F2NF@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rpl14	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0097159,GO:1901363,GO:1990904	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
MMS3_k127_3229872_10	1198449.ACAM_0266	4.938e-18	97.0	COG0198@1|root,arCOG04094@2157|Archaea,2XQQB@28889|Crenarchaeota	28889|Crenarchaeota	J	Located at the polypeptide exit tunnel on the outside of the subunit	rpl24	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,Ribosomal_L26
MMS3_k127_3229872_1	243232.MJ_0468	3.854e-45	182.0	COG1471@1|root,arCOG04093@2157|Archaea,2XT03@28890|Euryarchaeota,23Q1P@183939|Methanococci	183939|Methanococci	J	Belongs to the eukaryotic ribosomal protein eS4 family	rps4e	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02987	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	RS4NT,Ribosomal_S4e,S4
MMS3_k127_3229872_2	1054217.TALC_01321	9.222e-44	168.0	COG0094@1|root,arCOG04092@2157|Archaea,2XTRN@28890|Euryarchaeota,241QF@183967|Thermoplasmata	183967|Thermoplasmata	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rpl5	-	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
MMS3_k127_3229872_9	1236689.MMALV_14120	4.059e-18	85.0	COG0199@1|root,arCOG00782@2157|Archaea,2Y68V@28890|Euryarchaeota,3F2V3@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	ribosomal protein S14	rps14	-	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
MMS3_k127_3229872_3	1236689.MMALV_14110	1.208e-40	153.0	COG0096@1|root,arCOG04091@2157|Archaea,2XWMU@28890|Euryarchaeota,3F2NR@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rps8	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
MMS3_k127_3229872_4	272844.PAB2132	5.497e-39	152.0	COG0097@1|root,arCOG04090@2157|Archaea,2XTIS@28890|Euryarchaeota,243D5@183968|Thermococci	183968|Thermococci	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rpl6	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
MMS3_k127_3229872_8	673860.AciM339_1115	8.488e-27	123.0	COG1717@1|root,arCOG00781@2157|Archaea,2XSZ4@28890|Euryarchaeota,3F2PV@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Belongs to the eukaryotic ribosomal protein eL32 family	rpl32e	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02912	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	HHH_5,Ribosomal_L32e
MMS3_k127_3229872_5	439481.Aboo_1503	4.817e-37	145.0	COG2147@1|root,arCOG04089@2157|Archaea,2XWU1@28890|Euryarchaeota,3F2Q2@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	binds to the 23S rRNA	rpl19e	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02885	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19e
MMS3_k127_3229872_6	368407.Memar_0583	9.421e-36	141.0	COG0256@1|root,arCOG04088@2157|Archaea,2XTWT@28890|Euryarchaeota,2N9SW@224756|Methanomicrobia	224756|Methanomicrobia	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rpl18	-	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5e
MMS3_k127_3268267_4	518766.Rmar_1336	2.21e-14	74.0	COG0314@1|root,COG0314@2|Bacteria,4NP1X@976|Bacteroidetes	976|Bacteroidetes	H	Molybdopterin converting factor	moaE	-	2.8.1.12	ko:K03635	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoaE
MMS3_k127_3268267_0	156889.Mmc1_1098	2.366e-183	604.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,2TR24@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	COG1042 Acyl-CoA synthetase (NDP forming)	-	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
MMS3_k127_3268267_1	1121430.JMLG01000003_gene526	4.387e-77	270.0	COG0489@1|root,COG0489@2|Bacteria,1TQ34@1239|Firmicutes,24817@186801|Clostridia,260JH@186807|Peptococcaceae	186801|Clostridia	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	mrp	-	-	-	-	-	-	-	-	-	-	-	ParA
MMS3_k127_3268267_5	456320.Mvol_1339	2.141e-08	66.0	COG1916@1|root,arCOG02142@2157|Archaea,2XTNE@28890|Euryarchaeota,23QQB@183939|Methanococci	183939|Methanococci	S	PFAM TraB determinant protein	-	-	-	-	-	-	-	-	-	-	-	-	TraB
MMS3_k127_3268267_6	673860.AciM339_0088	1.45e-06	60.0	arCOG06692@1|root,arCOG06692@2157|Archaea,2Y53M@28890|Euryarchaeota,3F3HV@33867|unclassified Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_3268267_2	439481.Aboo_1171	2.873e-65	231.0	COG1100@1|root,arCOG01225@2157|Archaea,2XWN4@28890|Euryarchaeota,3F2J6@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Conserved hypothetical ATP binding protein	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	ATP_bind_1
MMS3_k127_3268267_7	523841.HFX_1116	1.522e-06	55.0	COG1400@1|root,arCOG01217@2157|Archaea,2XYV0@28890|Euryarchaeota,23WWX@183963|Halobacteria	183963|Halobacteria	J	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP	srp19	-	-	ko:K03105	ko03060,map03060	-	-	-	ko00000,ko00001,ko02044	3.A.5.7,3.A.5.9	-	-	SRP19
MMS3_k127_3268267_3	673860.AciM339_1543	1.203e-27	115.0	COG2007@1|root,arCOG04154@2157|Archaea,2XYXX@28890|Euryarchaeota,3F2SE@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Ribosomal protein S8e	rps8e	GO:0000462,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044085,GO:0044237,GO:0044238,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360,GO:1990904	-	ko:K02995	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8e
MMS3_k127_3324506_9	994479.GL877879_gene5183	1.761e-24	121.0	COG0433@1|root,COG0433@2|Bacteria,2H4H2@201174|Actinobacteria,4DYZ5@85010|Pseudonocardiales	201174|Actinobacteria	T	Type IV secretion-system coupling protein DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF87,TraG-D_C,TrwB_AAD_bind
MMS3_k127_3324506_5	273116.14325755	5.325e-54	207.0	COG0582@1|root,arCOG01241@2157|Archaea,2XWM9@28890|Euryarchaeota	28890|Euryarchaeota	L	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_3324506_1	1047013.AQSP01000037_gene1326	8.969e-106	350.0	COG1830@1|root,COG1830@2|Bacteria,2NPYC@2323|unclassified Bacteria	2|Bacteria	G	DeoC/LacD family aldolase	lsrF	GO:0003674,GO:0003824,GO:0016740,GO:0016746,GO:0016747	2.3.1.245,4.1.2.13	ko:K08321,ko:K11645	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko02024,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map02024	M00001,M00003	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	DeoC
MMS3_k127_3324506_6	391623.TERMP_00265	1.705e-32	132.0	COG1522@1|root,arCOG01580@2157|Archaea,2XWJA@28890|Euryarchaeota,243ZM@183968|Thermococci	183968|Thermococci	K	transcription regulator activity	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_24
MMS3_k127_3324506_0	330779.Saci_1483	8.476e-151	492.0	COG0174@1|root,arCOG01909@2157|Archaea,2XPM9@28889|Crenarchaeota	28889|Crenarchaeota	E	PFAM Glutamine synthetase, catalytic	glnA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
MMS3_k127_3324506_4	1365176.N186_05410	1.383e-69	255.0	COG1574@1|root,arCOG00691@2157|Archaea,2XPRG@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM Amidohydrolase 3	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
MMS3_k127_3324506_8	69014.TK0927	7.875e-27	123.0	COG0101@1|root,arCOG04449@2157|Archaea,2XTH5@28890|Euryarchaeota,242SP@183968|Thermococci	183968|Thermococci	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
MMS3_k127_3324506_10	1255043.TVNIR_2084	6.155e-19	100.0	COG0317@1|root,COG0317@2|Bacteria,1RGUA@1224|Proteobacteria,1S3WT@1236|Gammaproteobacteria,1WY7Z@135613|Chromatiales	135613|Chromatiales	KT	HD domain	-	-	2.7.6.5,3.1.7.2	ko:K01139	ko00230,map00230	-	R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009	-	-	-	HD_4
MMS3_k127_3324506_11	1220534.B655_1216	1.259e-18	95.0	COG0864@1|root,arCOG01008@2157|Archaea	2157|Archaea	K	Transcriptional regulator	-	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141	-	ko:K07722	-	-	-	-	ko00000,ko03000	-	-	-	NikR_C,RHH_1
MMS3_k127_3324506_2	456442.Mboo_0975	1.017e-100	340.0	COG3376@1|root,arCOG06023@2157|Archaea,2Y3CP@28890|Euryarchaeota	28890|Euryarchaeota	P	Belongs to the NiCoT transporter (TC 2.A.52) family	-	-	-	ko:K07241	-	-	-	-	ko00000,ko02000	2.A.52.1	-	-	NicO
MMS3_k127_3324506_13	273057.SSO0821	1.364e-12	78.0	COG0500@1|root,arCOG01400@2157|Archaea,2XRAC@28889|Crenarchaeota	28889|Crenarchaeota	Q	Methyltransferase FkbM domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_21
MMS3_k127_3324506_3	1047013.AQSP01000122_gene2224	3.184e-71	276.0	COG3291@1|root,COG5434@1|root,COG3291@2|Bacteria,COG5434@2|Bacteria,2NQ6Y@2323|unclassified Bacteria	2|Bacteria	M	PKD domain	-	-	3.2.1.157,3.2.1.91	ko:K19668,ko:K20850	ko00500,ko01100,ko02020,map00500,map01100,map02020	-	R02886,R11308	RC00799	ko00000,ko00001,ko01000	-	GH6,GH82	-	Beta_helix,CHU_C,Cadherin-like,FlgD_ig,PKD,Pectate_lyase_3
MMS3_k127_3324506_14	219305.MCAG_01472	1.419e-10	76.0	COG2133@1|root,COG3291@1|root,COG2133@2|Bacteria,COG3291@2|Bacteria,2GJFY@201174|Actinobacteria,4DBK6@85008|Micromonosporales	201174|Actinobacteria	G	Cellulose Binding Domain Type IV	-	-	-	-	-	-	-	-	-	-	-	-	CBM_6,DUF1080,GSDH,PKD,RicinB_lectin_2,Ricin_B_lectin,ThuA
MMS3_k127_3324506_12	673862.BABL1_1004	4.279e-16	93.0	COG3209@1|root,COG3209@2|Bacteria,1QW4H@1224|Proteobacteria,42ZEZ@68525|delta/epsilon subdivisions,2WT5G@28221|Deltaproteobacteria	1224|Proteobacteria	M	Immunoglobulin-like repeats containing protein domain	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Autotransporter,Big_3_5,DUF4347,He_PIG,RHS_repeat
MMS3_k127_3324506_7	1056495.Calag_1003	1.916e-29	138.0	COG3391@1|root,arCOG06052@1|root,arCOG02560@2157|Archaea,arCOG06052@2157|Archaea,2XRYP@28889|Crenarchaeota	28889|Crenarchaeota	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_3335068_7	1007103.AFHW01000017_gene5859	1.593e-17	83.0	COG2320@1|root,COG2320@2|Bacteria,1V3IB@1239|Firmicutes,4HKXN@91061|Bacilli,26X07@186822|Paenibacillaceae	91061|Bacilli	S	GrpB protein	-	-	-	-	-	-	-	-	-	-	-	-	GrpB
MMS3_k127_3335068_3	926560.KE387023_gene1738	3.507e-75	274.0	COG4122@1|root,COG4122@2|Bacteria,1WKHV@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	O-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_3
MMS3_k127_3335068_9	446471.Xcel_2757	0.0001137	53.0	COG0454@1|root,COG0456@2|Bacteria,2IGM1@201174|Actinobacteria	201174|Actinobacteria	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
MMS3_k127_3335068_6	861299.J421_4277	3.853e-55	208.0	COG0276@1|root,COG0276@2|Bacteria,1ZTW1@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Catalyzes the ferrous insertion into protoporphyrin IX	hemH	-	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	Ferrochelatase
MMS3_k127_3335068_2	47763.JNZA01000022_gene2730	2.736e-84	313.0	COG0407@1|root,COG0407@2|Bacteria,2GMY6@201174|Actinobacteria	201174|Actinobacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	hemE	GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
MMS3_k127_3335068_0	1242864.D187_004448	5.807e-129	437.0	COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,42MBF@68525|delta/epsilon subdivisions,2WJQ2@28221|Deltaproteobacteria,2YU3Q@29|Myxococcales	28221|Deltaproteobacteria	H	Aminotransferase	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
MMS3_k127_3335068_4	278963.ATWD01000002_gene955	1.888e-58	222.0	COG3253@1|root,COG3253@2|Bacteria,3Y39D@57723|Acidobacteria,2JK6X@204432|Acidobacteriia	204432|Acidobacteriia	S	PFAM Chlorite dismutase	-	-	-	-	-	-	-	-	-	-	-	-	Chlor_dismutase
MMS3_k127_3335068_1	1382306.JNIM01000001_gene2464	2.954e-106	353.0	COG0113@1|root,COG0113@2|Bacteria,2G5QT@200795|Chloroflexi	200795|Chloroflexi	H	Belongs to the ALAD family	hemB	-	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
MMS3_k127_3335068_10	1123065.ATWL01000011_gene57	0.0004028	53.0	COG1587@1|root,COG1587@2|Bacteria,2GMJZ@201174|Actinobacteria	201174|Actinobacteria	H	Uroporphyrinogen-III synthase	hemD	-	2.1.1.107,4.2.1.75	ko:K01719,ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165,R03194	RC00003,RC00871,RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4,TP_methylase
MMS3_k127_3335068_5	309801.trd_1125	1.108e-55	215.0	COG0181@1|root,COG1587@1|root,COG0181@2|Bacteria,COG1587@2|Bacteria,2G6JU@200795|Chloroflexi,27Y7G@189775|Thermomicrobia	189775|Thermomicrobia	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	-	-	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	-	Porphobil_deam,Porphobil_deamC
MMS3_k127_3335068_8	1172185.KB911516_gene2374	9.39e-16	86.0	COG0373@1|root,COG0373@2|Bacteria,2GJRA@201174|Actinobacteria,4FUGW@85025|Nocardiaceae	201174|Actinobacteria	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	GO:0008150,GO:0040007	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
MMS3_k127_3346401_3	345341.KUTG_05601	1.466e-21	109.0	COG0433@1|root,COG0433@2|Bacteria,2H4H2@201174|Actinobacteria,4E9H4@85010|Pseudonocardiales	201174|Actinobacteria	S	COG0433 Predicted ATPase	-	-	-	-	-	-	-	-	-	-	-	-	TraG-D_C,TrwB_AAD_bind
MMS3_k127_3346401_0	439481.Aboo_0716	6.966e-89	300.0	COG0467@1|root,arCOG01171@2157|Archaea,2XTU3@28890|Euryarchaeota,3F31P@33867|unclassified Euryarchaeota	28890|Euryarchaeota	T	Rad51	-	-	-	-	-	-	-	-	-	-	-	-	ATPase
MMS3_k127_3346401_2	439481.Aboo_0715	4.886e-28	120.0	arCOG02452@1|root,arCOG02452@2157|Archaea,2Y71S@28890|Euryarchaeota,3F36K@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	COG0467 RecA-superfamily ATPases implicated in signal transduction	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_3346401_1	439481.Aboo_0714	1.975e-38	158.0	COG0467@1|root,arCOG01171@2157|Archaea,2Y69G@28890|Euryarchaeota,3F39I@33867|unclassified Euryarchaeota	28890|Euryarchaeota	T	Pfam:KaiC	-	-	-	-	-	-	-	-	-	-	-	-	ATPase
MMS3_k127_3347852_5	485913.Krac_0030	7.133e-42	162.0	COG2320@1|root,COG2320@2|Bacteria,2G94B@200795|Chloroflexi	2|Bacteria	S	GrpB protein	-	-	-	-	-	-	-	-	-	-	-	-	GrpB
MMS3_k127_3347852_12	644281.MFS40622_1211	1.703e-08	65.0	COG2023@1|root,arCOG04345@2157|Archaea,2XYX0@28890|Euryarchaeota,23R50@183939|Methanococci	183939|Methanococci	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp4	GO:0000966,GO:0001682,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0032991,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1902555,GO:1905348,GO:1990904	3.1.26.5	ko:K03540	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Rpr2
MMS3_k127_3347852_8	1041930.Mtc_0663	1.007e-25	117.0	arCOG03142@1|root,arCOG03142@2157|Archaea,2XTSE@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_3347852_2	272844.PAB0323	2.144e-100	348.0	COG0008@1|root,arCOG04302@2157|Archaea,2XSYV@28890|Euryarchaeota,242MB@183968|Thermococci	183968|Thermococci	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
MMS3_k127_3347852_9	1198232.CYCME_1092	1.395e-20	100.0	COG0346@1|root,COG0346@2|Bacteria,1RCYX@1224|Proteobacteria,1S1Z9@1236|Gammaproteobacteria,460J9@72273|Thiotrichales	72273|Thiotrichales	E	Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione	gloA	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
MMS3_k127_3347852_11	768679.TTX_0026	8.853e-16	91.0	COG0477@1|root,arCOG00130@2157|Archaea	2157|Archaea	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
MMS3_k127_3347852_4	933262.AXAM01000100_gene3386	8.42e-47	180.0	COG0053@1|root,COG0053@2|Bacteria,1MVH8@1224|Proteobacteria,42R5A@68525|delta/epsilon subdivisions,2WN5N@28221|Deltaproteobacteria,2MN9Y@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Cation efflux family	catA	-	-	ko:K14696	-	-	-	-	ko00000,ko02000	2.A.4.6	-	-	Cation_efflux,ZT_dimer
MMS3_k127_3347852_1	1051632.TPY_1071	4.957e-104	359.0	COG1830@1|root,COG1830@2|Bacteria,1TR4S@1239|Firmicutes,24CYU@186801|Clostridia	186801|Clostridia	G	DeoC/LacD family aldolase	-	-	4.1.2.13	ko:K11645	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	DeoC
MMS3_k127_3347852_7	8496.XP_006268523.1	1.633e-26	119.0	COG2042@1|root,KOG3154@2759|Eukaryota,38FB5@33154|Opisthokonta,3BIFK@33208|Metazoa,3CTKF@33213|Bilateria,483VP@7711|Chordata,48ZRN@7742|Vertebrata	33208|Metazoa	S	maturation of SSU-rRNA	TSR3	GO:0000154,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0022613,GO:0030490,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	-	ko:K09140	-	-	-	-	ko00000,ko03009	-	-	-	RLI,Ribo_biogen_C
MMS3_k127_3347852_6	1123376.AUIU01000015_gene443	1.901e-36	151.0	COG0639@1|root,COG0639@2|Bacteria	2|Bacteria	T	phosphoprotein phosphatase activity	-	-	3.1.3.16	ko:K07313	-	-	-	-	ko00000,ko01000	-	-	-	Metallophos
MMS3_k127_3347852_0	264732.Moth_0405	1.387e-115	396.0	COG4986@1|root,COG4986@2|Bacteria,1TRRR@1239|Firmicutes,248X4@186801|Clostridia,42HSS@68295|Thermoanaerobacterales	186801|Clostridia	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
MMS3_k127_3347852_3	264732.Moth_0406	5.359e-88	301.0	COG1116@1|root,COG1116@2|Bacteria,1TRM6@1239|Firmicutes,248CG@186801|Clostridia,42G07@68295|Thermoanaerobacterales	186801|Clostridia	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	AAA_assoc_C,ABC_tran
MMS3_k127_3347852_10	1051632.TPY_0028	8.273e-19	94.0	COG1116@1|root,COG4754@1|root,COG1116@2|Bacteria,COG4754@2|Bacteria,1TRM6@1239|Firmicutes,248CG@186801|Clostridia	186801|Clostridia	P	ABC-type nitrate sulfonate bicarbonate transport system ATPase component	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	AAA_assoc_C,ABC_tran
MMS3_k127_3350636_4	582515.KR51_00000990	1.602e-21	95.0	COG0603@1|root,COG0603@2|Bacteria,1G24C@1117|Cyanobacteria	1117|Cyanobacteria	F	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))	queC	-	6.3.4.20	ko:K06920	ko00790,ko01100,map00790,map01100	-	R09978	RC00959	ko00000,ko00001,ko01000,ko03016	-	-	-	QueC
MMS3_k127_3350636_3	469383.Cwoe_1383	6.125e-28	118.0	COG1970@1|root,COG1970@2|Bacteria,2IQDN@201174|Actinobacteria	201174|Actinobacteria	M	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell	-	-	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
MMS3_k127_3350636_1	304371.MCP_2679	1.56e-103	359.0	COG0018@1|root,arCOG00487@2157|Archaea,2XTWP@28890|Euryarchaeota,2N9C5@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
MMS3_k127_3350636_2	224719.Abm4_0262	4.73e-33	140.0	COG0301@1|root,arCOG00038@2157|Archaea,2XUHM@28890|Euryarchaeota,23NP8@183925|Methanobacteria	183925|Methanobacteria	H	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	thiI	-	2.8.1.4	ko:K03151	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07461	-	ko00000,ko00001,ko01000,ko03016	-	-	-	THUMP,ThiI
MMS3_k127_3350636_0	1382306.JNIM01000001_gene3777	1.057e-133	450.0	COG2303@1|root,COG2303@2|Bacteria,2G7EB@200795|Chloroflexi	200795|Chloroflexi	E	GMC oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N
MMS3_k127_3370327_0	562970.Btus_0008	2.581e-106	361.0	COG0188@1|root,COG0188@2|Bacteria,1TP2Z@1239|Firmicutes,4HAHY@91061|Bacilli,2783E@186823|Alicyclobacillaceae	91061|Bacilli	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
MMS3_k127_3370327_2	593750.Metfor_2096	5.907e-05	49.0	arCOG06113@1|root,arCOG06113@2157|Archaea	2157|Archaea	-	-	-	-	-	ko:K06193	ko01120,map01120	-	-	-	ko00000	-	-	-	TF_Zn_Ribbon
MMS3_k127_3370327_1	1125863.JAFN01000001_gene2162	1.424e-57	208.0	COG0294@1|root,COG0294@2|Bacteria,1MUIR@1224|Proteobacteria,42MMY@68525|delta/epsilon subdivisions,2WIXA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	folP	-	2.5.1.15,2.7.6.3	ko:K00796,ko:K13941	ko00790,ko01100,map00790,map01100	M00126,M00840,M00841	R03066,R03067,R03503	RC00002,RC00017,RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
MMS3_k127_3376196_17	1449353.JQMQ01000004_gene6490	3.76e-06	54.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase,Glyoxalase_2
MMS3_k127_3376196_19	1410638.JHXJ01000036_gene886	4.861e-05	51.0	COG0500@1|root,COG0500@2|Bacteria,1TSZK@1239|Firmicutes,24DAN@186801|Clostridia	186801|Clostridia	Q	Thiopurine S-methyltransferase (TPMT)	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,TehB
MMS3_k127_3376196_9	1132509.C447_07438	9.099e-21	98.0	arCOG03570@1|root,arCOG03570@2157|Archaea,2XXIA@28890|Euryarchaeota,23VKN@183963|Halobacteria	183963|Halobacteria	Q	COG0500 SAM-dependent methyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	TehB
MMS3_k127_3376196_1	479431.Namu_0021	7.721e-78	274.0	COG4447@1|root,COG4447@2|Bacteria,2GM8J@201174|Actinobacteria,4ESAS@85013|Frankiales	201174|Actinobacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR
MMS3_k127_3376196_16	671065.MetMK1DRAFT_00005900	2.552e-10	72.0	arCOG03768@1|root,arCOG03768@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF973
MMS3_k127_3376196_3	661478.OP10G_1462	1.012e-48	179.0	COG2764@1|root,COG2764@2|Bacteria	2|Bacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	ko:K04750	-	-	-	-	ko00000	-	-	-	Glyoxalase
MMS3_k127_3376196_18	1123321.KB905813_gene1338	3.243e-05	50.0	COG1846@1|root,COG1846@2|Bacteria,2IHP0@201174|Actinobacteria	201174|Actinobacteria	K	marr family	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
MMS3_k127_3376196_2	1356854.N007_14445	1.064e-74	269.0	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
MMS3_k127_3376196_12	1408813.AYMG01000014_gene1651	5.872e-17	96.0	COG1361@1|root,COG3291@1|root,COG4625@1|root,COG1361@2|Bacteria,COG3291@2|Bacteria,COG4625@2|Bacteria,4NDZC@976|Bacteroidetes,1IRJP@117747|Sphingobacteriia	976|Bacteroidetes	M	C-terminal domain of CHU protein family	-	-	-	ko:K21449	-	-	-	-	ko00000,ko02000	1.B.40.2	-	-	CHU_C,DUF11,He_PIG,fn3
MMS3_k127_3376196_6	867845.KI911784_gene2277	3.916e-25	123.0	COG0457@1|root,COG1404@1|root,COG3055@1|root,COG0457@2|Bacteria,COG1404@2|Bacteria,COG3055@2|Bacteria,2G8UU@200795|Chloroflexi,3759F@32061|Chloroflexia	32061|Chloroflexia	O	PFAM peptidase S8 and S53, subtilisin, kexin, sedolisin	-	-	-	-	-	-	-	-	-	-	-	-	Kelch_4,Kelch_5,Peptidase_S8
MMS3_k127_3376196_15	1137269.AZWL01000014_gene845	6.234e-15	85.0	COG0262@1|root,COG0262@2|Bacteria,2IFTI@201174|Actinobacteria	201174|Actinobacteria	H	RibD C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
MMS3_k127_3376196_13	643648.Slip_0651	1.22e-15	87.0	COG1011@1|root,COG1011@2|Bacteria	2|Bacteria	S	phosphatase activity	-	-	3.1.3.102,3.1.3.104,3.1.3.5	ko:K07025,ko:K08723,ko:K20862	ko00230,ko00240,ko00740,ko00760,ko01100,ko01110,map00230,map00240,map00740,map00760,map01100,map01110	M00125	R00183,R00511,R00548,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346,R07280	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HAD_2,Hydrolase_like
MMS3_k127_3376196_11	698761.RTCIAT899_CH04575	6.039e-20	99.0	COG0346@1|root,COG0346@2|Bacteria,1PW4X@1224|Proteobacteria,2V7BJ@28211|Alphaproteobacteria,4BHUY@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_3376196_4	1121028.ARQE01000002_gene2223	2.385e-40	162.0	COG1225@1|root,COG1225@2|Bacteria,1MWJP@1224|Proteobacteria,2TSSW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Redoxin domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Redoxin
MMS3_k127_3376196_10	1206720.BAFQ01000102_gene2559	5.389e-20	106.0	COG1520@1|root,COG1520@2|Bacteria,2IAZ2@201174|Actinobacteria,4FZ09@85025|Nocardiaceae	201174|Actinobacteria	S	PQQ enzyme repeat	-	-	1.1.2.6,2.7.11.1	ko:K05889,ko:K12132	-	-	R03136	-	ko00000,ko01000,ko01001	-	-	-	PQQ,PQQ_2,PQQ_3,Pkinase
MMS3_k127_3376196_7	463191.SSEG_07468	1.713e-23	113.0	COG1028@1|root,COG1028@2|Bacteria,2GP7P@201174|Actinobacteria	201174|Actinobacteria	IQ	Short-chain dehydrogenase reductase sdr	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
MMS3_k127_3376196_0	1121472.AQWN01000004_gene802	4.147e-135	445.0	COG0004@1|root,COG0004@2|Bacteria,1TQYG@1239|Firmicutes,247W1@186801|Clostridia,2603A@186807|Peptococcaceae	186801|Clostridia	U	TIGRFAM Ammonium transporter	nrgA	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
MMS3_k127_3376196_5	1111069.TCCBUS3UF1_20360	8.176e-29	133.0	COG0500@1|root,COG2226@2|Bacteria,1WJAK@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
MMS3_k127_3376196_14	1449353.JQMQ01000004_gene6175	5.121e-15	85.0	COG0517@1|root,COG0517@2|Bacteria,2GKSH@201174|Actinobacteria,2NJHB@228398|Streptacidiphilus	201174|Actinobacteria	S	BON domain	-	-	-	-	-	-	-	-	-	-	-	-	BON,CBS
MMS3_k127_3376196_8	1300345.LF41_1458	6.027e-21	107.0	COG2309@1|root,COG2309@2|Bacteria	2|Bacteria	E	aminopeptidase activity	-	-	-	ko:K19689	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	HTH_20,Peptidase_M29
MMS3_k127_3383704_1	246969.TAM4_1370	2.024e-79	268.0	COG1156@1|root,arCOG00865@2157|Archaea,2XSYQ@28890|Euryarchaeota,2433N@183968|Thermococci	183968|Thermococci	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit	atpB	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
MMS3_k127_3383704_3	273116.14324267	1.953e-42	165.0	COG1394@1|root,arCOG04101@2157|Archaea,2XTQ5@28890|Euryarchaeota,241TN@183967|Thermoplasmata	183967|Thermoplasmata	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpD	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
MMS3_k127_3383704_0	273075.Ta0008	1.078e-117	407.0	COG1269@1|root,arCOG04138@2157|Archaea,2XTQP@28890|Euryarchaeota,241UP@183967|Thermoplasmata	183967|Thermoplasmata	C	V-type ATPase 116kDa subunit family	-	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
MMS3_k127_3383704_2	273075.Ta0002	1.329e-57	216.0	COG1527@1|root,arCOG02459@2157|Archaea,2Y67I@28890|Euryarchaeota,24275@183967|Thermoplasmata	183967|Thermoplasmata	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	-	-	ko:K02119	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_AC39
MMS3_k127_3383704_7	572546.Arcpr_1643	1.21e-06	59.0	COG1390@1|root,arCOG00869@2157|Archaea,2XWGX@28890|Euryarchaeota,24687@183980|Archaeoglobi	183980|Archaeoglobi	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpE	-	-	ko:K02121	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_E
MMS3_k127_3383704_5	263820.PTO0494	9.477e-25	107.0	COG0636@1|root,arCOG02455@2157|Archaea,2Y1B9@28890|Euryarchaeota,242DV@183967|Thermoplasmata	183967|Thermoplasmata	C	ATP synthase subunit C	-	-	-	ko:K02124	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_C
MMS3_k127_3383704_4	103733.JNYO01000025_gene8925	3.261e-33	139.0	COG2043@1|root,COG2043@2|Bacteria,2ISFS@201174|Actinobacteria,4EB4E@85010|Pseudonocardiales	201174|Actinobacteria	S	Uncharacterised ArCR, COG2043	-	-	-	-	-	-	-	-	-	-	-	-	DUF169
MMS3_k127_3383704_6	399549.Msed_2203	1.61e-18	102.0	COG0747@1|root,arCOG01533@2157|Archaea	2157|Archaea	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	PKD,SBP_bac_5
MMS3_k127_3454394_1	1236689.MMALV_00330	4.598e-164	523.0	COG1405@1|root,arCOG01981@2157|Archaea,2XT0Z@28890|Euryarchaeota,3F2FH@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	tfb	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
MMS3_k127_3454394_3	518766.Rmar_1872	1.379e-53	196.0	COG0299@1|root,COG0299@2|Bacteria,4NNZP@976|Bacteroidetes,1FITI@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	purN	-	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	Formyl_trans_N
MMS3_k127_3454394_9	1198449.ACAM_0517	3.949e-19	101.0	COG1475@1|root,arCOG01875@2157|Archaea,2XSRF@28889|Crenarchaeota	28889|Crenarchaeota	K	ParB-like nuclease domain	-	-	-	-	-	-	-	-	-	-	-	-	ParBc
MMS3_k127_3454394_2	76114.ebA3602	7.888e-57	228.0	COG1319@1|root,COG1319@2|Bacteria,1MVJS@1224|Proteobacteria,2VI0S@28216|Betaproteobacteria,2KVVU@206389|Rhodocyclales	206389|Rhodocyclales	C	CO dehydrogenase flavoprotein C-terminal domain	hcrB	-	1.3.7.9	ko:K04109	ko00362,ko00627,ko01100,ko01120,ko01220,map00362,map00627,map01100,map01120,map01220	-	R05316	RC00490	ko00000,ko00001,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
MMS3_k127_3454394_0	1382306.JNIM01000001_gene1023	7.46e-203	663.0	COG1529@1|root,COG1529@2|Bacteria	2|Bacteria	C	xanthine dehydrogenase activity	hcrA	-	1.3.7.9	ko:K04108	ko00362,ko00627,ko01100,ko01120,ko01220,map00362,map00627,map01100,map01120,map01220	-	R05316	RC00490	ko00000,ko00001,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
MMS3_k127_3454394_5	196367.JNFG01000011_gene6225	1.553e-46	175.0	COG2080@1|root,COG2080@2|Bacteria,1MWA6@1224|Proteobacteria,2WEMC@28216|Betaproteobacteria	28216|Betaproteobacteria	C	[2Fe-2S] binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer2,Fer2_2
MMS3_k127_3454394_6	1187851.A33M_4182	5.599e-37	157.0	COG1975@1|root,COG1975@2|Bacteria,1MWFN@1224|Proteobacteria,2TS6Z@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	COG1975 Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family	coxF	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI
MMS3_k127_3454394_11	584708.Apau_1917	2.71e-13	81.0	COG2068@1|root,COG2068@2|Bacteria,3TAXV@508458|Synergistetes	508458|Synergistetes	H	PFAM metal-dependent phosphohydrolase HD sub domain	-	-	-	-	-	-	-	-	-	-	-	-	HD,NTP_transf_3
MMS3_k127_3454394_7	192952.MM_0802	2.444e-34	150.0	COG2238@1|root,arCOG01344@2157|Archaea,2XXA6@28890|Euryarchaeota,2N9QY@224756|Methanomicrobia	224756|Methanomicrobia	J	May be involved in maturation of the 30S ribosomal subunit	rps19e	-	-	ko:K02966	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19e
MMS3_k127_3454394_8	1041930.Mtc_0435	9.725e-22	99.0	COG2118@1|root,arCOG04179@2157|Archaea,2XZUR@28890|Euryarchaeota,2N9ZR@224756|Methanomicrobia	224756|Methanomicrobia	S	Belongs to the PDCD5 family	-	-	-	ko:K06875	-	-	-	-	ko00000	-	-	-	dsDNA_bind
MMS3_k127_3454394_13	439481.Aboo_0026	5.87e-09	60.0	COG2167@1|root,arCOG04177@2157|Archaea,2Y6Y7@28890|Euryarchaeota,3F2VP@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Belongs to the eukaryotic ribosomal protein eL39 family	rpl39e	-	-	ko:K02924	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L39
MMS3_k127_3454394_10	634498.mru_0400	1.024e-15	82.0	COG2097@1|root,arCOG04473@2157|Archaea,2XYWX@28890|Euryarchaeota,23P8C@183925|Methanobacteria	183925|Methanobacteria	J	Belongs to the ribosomal protein L31e family	rpl31e	-	-	ko:K02910	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31e
MMS3_k127_3454394_4	797209.ZOD2009_01645	1.492e-49	184.0	COG1976@1|root,arCOG04176@2157|Archaea,2XU7N@28890|Euryarchaeota,23SZE@183963|Halobacteria	183963|Halobacteria	J	Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex	eif6	-	-	ko:K03264	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009,ko03012	-	-	-	eIF-6
MMS3_k127_3454394_12	523850.TON_1230	2.916e-12	71.0	COG1383@1|root,arCOG01885@2157|Archaea,2Y07I@28890|Euryarchaeota,244GA@183968|Thermococci	183968|Thermococci	J	Belongs to the eukaryotic ribosomal protein eS17 family	rps17e	GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02962	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17e
MMS3_k127_3454394_14	29850.GGTG_02075T0	0.0002395	53.0	COG2304@1|root,2REND@2759|Eukaryota,38TNH@33154|Opisthokonta,3P1BG@4751|Fungi,3QSME@4890|Ascomycota,214D3@147550|Sordariomycetes,41PB9@639021|Magnaporthales	4751|Fungi	S	Hint-domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA,VWA_2,VWA_3,Vint,Vwaint
MMS3_k127_3499414_3	439481.Aboo_1056	1.909e-44	180.0	COG3451@1|root,arCOG04035@2157|Archaea,arCOG07496@2157|Archaea,2XTGE@28890|Euryarchaeota	28890|Euryarchaeota	U	COG3451 Type IV secretory pathway, VirB4 components	-	-	-	-	-	-	-	-	-	-	-	-	AAA_10,DUF87
MMS3_k127_3499414_2	243232.MJ_0985	6.884e-82	283.0	COG0863@1|root,arCOG00115@2157|Archaea,2XT30@28890|Euryarchaeota,23RNE@183939|Methanococci	183939|Methanococci	L	DNA methylase	-	-	2.1.1.113	ko:K00590	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
MMS3_k127_3499414_0	673860.AciM339_0590	7.593e-149	482.0	COG0269@1|root,arCOG00053@2157|Archaea,2XV47@28890|Euryarchaeota,3F2IP@33867|unclassified Euryarchaeota	28890|Euryarchaeota	G	Aldolase/RraA	-	-	4.1.2.43,5.3.1.27	ko:K13831	ko00030,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00680,map01100,map01120,map01200,map01230	M00345,M00580	R05338,R05339,R09780	RC00377,RC00421,RC00422	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase,RraA-like
MMS3_k127_3499414_1	387631.Asulf_01416	2.292e-108	366.0	COG0582@1|root,arCOG01245@2157|Archaea,2Y83V@28890|Euryarchaeota,246UP@183980|Archaeoglobi	183980|Archaeoglobi	L	integrase family	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_352129_1	1179773.BN6_04890	6.684e-29	132.0	COG1319@1|root,COG1319@2|Bacteria,2GT14@201174|Actinobacteria,4DXHU@85010|Pseudonocardiales	201174|Actinobacteria	C	carbon monoxide dehydrogenase	cutM	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
MMS3_k127_352129_2	1236689.MMALV_16490	1.117e-26	125.0	COG0640@1|root,arCOG05349@2157|Archaea,2XYUG@28890|Euryarchaeota,3F2RP@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	DNA-binding transcription factor activity	-	-	-	-	-	-	-	-	-	-	-	-	HTH_11,HTH_5
MMS3_k127_352129_3	673860.AciM339_1279	9.579e-08	63.0	arCOG05352@1|root,arCOG05352@2157|Archaea,2Y75N@28890|Euryarchaeota,3F3FP@33867|unclassified Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_352129_0	1041930.Mtc_0469	6.806e-272	866.0	COG1933@1|root,arCOG04447@2157|Archaea,2XU5S@28890|Euryarchaeota,2N91E@224756|Methanomicrobia	224756|Methanomicrobia	L	Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase	polC	-	2.7.7.7	ko:K02322	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	M00264	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	PolC_DP2
MMS3_k127_3543316_0	456442.Mboo_1317	6.462e-191	605.0	COG1282@1|root,arCOG09400@2157|Archaea,2XV3Y@28890|Euryarchaeota	28890|Euryarchaeota	C	PFAM NAD(P) transhydrogenase, beta subunit	-	-	1.6.1.2	ko:K00325	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB
MMS3_k127_3543316_4	593750.Metfor_1673	2.66e-36	154.0	COG3288@1|root,arCOG09401@2157|Archaea,2XZE6@28890|Euryarchaeota	28890|Euryarchaeota	C	4TM region of pyridine nucleotide transhydrogenase, mitoch	-	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB_4TM
MMS3_k127_3543316_1	456442.Mboo_1315	9.627e-157	503.0	COG0686@1|root,arCOG06678@2157|Archaea,2XV0Z@28890|Euryarchaeota	28890|Euryarchaeota	E	Alanine dehydrogenase/PNT, C-terminal domain	-	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
MMS3_k127_3543316_2	292459.STH2525	5.378e-58	213.0	COG0863@1|root,COG2189@1|root,COG0863@2|Bacteria,COG2189@2|Bacteria,1TR56@1239|Firmicutes,248NR@186801|Clostridia	186801|Clostridia	L	Belongs to the N(4) N(6)-methyltransferase family	-	-	2.1.1.113	ko:K00590	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
MMS3_k127_3543316_3	880072.Desac_2397	8.243e-56	206.0	COG3359@1|root,COG3359@2|Bacteria,1R6A2@1224|Proteobacteria,42MVN@68525|delta/epsilon subdivisions,2WK0C@28221|Deltaproteobacteria,2MR5S@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	RNase_H superfamily	-	-	-	ko:K07502	-	-	-	-	ko00000	-	-	-	RNase_H_2
MMS3_k127_3543316_8	9668.ENSMPUP00000013562	0.0002529	55.0	COG5599@1|root,KOG4228@2759|Eukaryota,38C1K@33154|Opisthokonta,3BA83@33208|Metazoa,3CXCZ@33213|Bilateria,480P3@7711|Chordata,48W4U@7742|Vertebrata,3J64X@40674|Mammalia,3EFBX@33554|Carnivora	33208|Metazoa	T	Protein tyrosine phosphatase, receptor type F	PTPRF	GO:0000003,GO:0000902,GO:0000904,GO:0001558,GO:0001654,GO:0001667,GO:0001745,GO:0001751,GO:0001754,GO:0001959,GO:0001960,GO:0002064,GO:0002065,GO:0002066,GO:0003006,GO:0003674,GO:0003824,GO:0004721,GO:0004725,GO:0004888,GO:0005001,GO:0005102,GO:0005158,GO:0005488,GO:0005515,GO:0005539,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005768,GO:0005886,GO:0005887,GO:0005912,GO:0005924,GO:0005925,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0006928,GO:0006935,GO:0006950,GO:0007154,GO:0007155,GO:0007156,GO:0007162,GO:0007165,GO:0007166,GO:0007167,GO:0007185,GO:0007275,GO:0007276,GO:0007281,GO:0007283,GO:0007292,GO:0007297,GO:0007399,GO:0007409,GO:0007411,GO:0007412,GO:0007416,GO:0007423,GO:0007528,GO:0008045,GO:0008150,GO:0008152,GO:0008285,GO:0008361,GO:0008594,GO:0009605,GO:0009653,GO:0009887,GO:0009888,GO:0009925,GO:0009966,GO:0009968,GO:0009987,GO:0010631,GO:0010646,GO:0010648,GO:0010720,GO:0010769,GO:0010770,GO:0010941,GO:0010942,GO:0010975,GO:0010976,GO:0012505,GO:0016020,GO:0016021,GO:0016043,GO:0016049,GO:0016311,GO:0016323,GO:0016477,GO:0016787,GO:0016788,GO:0016791,GO:0019198,GO:0019538,GO:0019899,GO:0019900,GO:0019901,GO:0019904,GO:0019953,GO:0022008,GO:0022407,GO:0022408,GO:0022412,GO:0022414,GO:0022603,GO:0022604,GO:0022607,GO:0022610,GO:0023051,GO:0023052,GO:0023057,GO:0030030,GO:0030054,GO:0030055,GO:0030154,GO:0030155,GO:0030182,GO:0030424,GO:0030426,GO:0030427,GO:0030516,GO:0030707,GO:0030855,GO:0030971,GO:0031099,GO:0031102,GO:0031175,GO:0031224,GO:0031226,GO:0031252,GO:0031290,GO:0031344,GO:0031345,GO:0031346,GO:0031410,GO:0031982,GO:0032091,GO:0032093,GO:0032101,GO:0032501,GO:0032502,GO:0032504,GO:0032535,GO:0032879,GO:0032989,GO:0032990,GO:0033267,GO:0033554,GO:0035335,GO:0035373,GO:0036211,GO:0036477,GO:0038023,GO:0040007,GO:0040008,GO:0040011,GO:0040012,GO:0042051,GO:0042058,GO:0042059,GO:0042127,GO:0042221,GO:0042301,GO:0042330,GO:0042461,GO:0042462,GO:0042578,GO:0042981,GO:0042995,GO:0043005,GO:0043025,GO:0043065,GO:0043067,GO:0043068,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043393,GO:0043394,GO:0043412,GO:0043523,GO:0043525,GO:0044085,GO:0044087,GO:0044089,GO:0044092,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044297,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044463,GO:0044464,GO:0044703,GO:0044877,GO:0045178,GO:0045202,GO:0045466,GO:0045467,GO:0045595,GO:0045597,GO:0045664,GO:0045666,GO:0046530,GO:0046626,GO:0046627,GO:0048232,GO:0048468,GO:0048477,GO:0048513,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048585,GO:0048588,GO:0048589,GO:0048592,GO:0048609,GO:0048638,GO:0048666,GO:0048667,GO:0048675,GO:0048679,GO:0048699,GO:0048731,GO:0048749,GO:0048812,GO:0048814,GO:0048841,GO:0048856,GO:0048858,GO:0048869,GO:0048870,GO:0050767,GO:0050769,GO:0050770,GO:0050773,GO:0050775,GO:0050789,GO:0050793,GO:0050794,GO:0050803,GO:0050808,GO:0050839,GO:0050896,GO:0050920,GO:0051094,GO:0051098,GO:0051100,GO:0051124,GO:0051128,GO:0051129,GO:0051130,GO:0051179,GO:0051239,GO:0051240,GO:0051270,GO:0051386,GO:0051387,GO:0051489,GO:0051491,GO:0051674,GO:0051704,GO:0051716,GO:0051960,GO:0051962,GO:0060076,GO:0060089,GO:0060269,GO:0060284,GO:0060429,GO:0060491,GO:0060560,GO:0060759,GO:0060761,GO:0061387,GO:0061564,GO:0065007,GO:0065008,GO:0065009,GO:0070161,GO:0070570,GO:0071704,GO:0071840,GO:0071944,GO:0080134,GO:0080135,GO:0090066,GO:0090130,GO:0090132,GO:0090287,GO:0090288,GO:0090596,GO:0097367,GO:0097374,GO:0097458,GO:0097485,GO:0097708,GO:0098590,GO:0098609,GO:0098742,GO:0120025,GO:0120032,GO:0120034,GO:0120035,GO:0120036,GO:0120038,GO:0120039,GO:0140096,GO:0150034,GO:1900006,GO:1900076,GO:1900077,GO:1900120,GO:1900121,GO:1901184,GO:1901185,GO:1901214,GO:1901216,GO:1901564,GO:1901681,GO:1902667,GO:1903034,GO:1903385,GO:1903386,GO:1990138,GO:1990782,GO:2000026	3.1.3.48	ko:K05695,ko:K06777	ko04514,ko04520,ko04910,ko04931,map04514,map04520,map04910,map04931	-	-	-	ko00000,ko00001,ko01000,ko01009,ko04516	-	-	-	I-set,Ig_3,Y_phosphatase,fn3
MMS3_k127_3543316_6	523845.AQXV01000050_gene969	9.552e-17	84.0	arCOG05874@1|root,arCOG05874@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_3586181_6	646529.Desaci_4368	8.145e-06	59.0	COG2247@1|root,COG4733@1|root,COG2247@2|Bacteria,COG4733@2|Bacteria,1UZS5@1239|Firmicutes,24FE6@186801|Clostridia,2600Z@186807|Peptococcaceae	186801|Clostridia	M	cell wall binding repeat 2	-	-	-	-	-	-	-	-	-	-	-	-	CW_binding_2,Endopep_inhib,fn3
MMS3_k127_3586181_7	768706.Desor_5449	1.228e-05	57.0	COG2247@1|root,COG3391@1|root,COG2247@2|Bacteria,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	CW_binding_2,Flg_new,VCBS
MMS3_k127_3586181_5	903814.ELI_4332	1.406e-06	61.0	COG0526@1|root,COG0785@1|root,COG0526@2|Bacteria,COG0785@2|Bacteria,1TQH1@1239|Firmicutes,249IS@186801|Clostridia,25XCF@186806|Eubacteriaceae	186801|Clostridia	O	Cytochrome C biogenesis protein transmembrane region	-	-	-	ko:K06196	-	-	-	-	ko00000,ko02000	5.A.1.2	-	-	AhpC-TSA,DsbD,Redoxin
MMS3_k127_3586181_4	797114.C475_11094	1.493e-12	80.0	arCOG04522@1|root,arCOG04522@2157|Archaea,2XTU5@28890|Euryarchaeota,23U1D@183963|Halobacteria	183963|Halobacteria	O	cytochrome c biogenesis protein	dsbD	-	-	ko:K06196	-	-	-	-	ko00000,ko02000	5.A.1.2	-	-	DsbD
MMS3_k127_3586181_3	1448860.BBJO01000034_gene528	2.456e-31	140.0	COG0613@1|root,arCOG00302@2157|Archaea,2XT0R@28890|Euryarchaeota,23SGT@183963|Halobacteria	183963|Halobacteria	S	metal-dependent phosphoesterases (PHP family)	-	-	-	-	-	-	-	-	-	-	-	-	PHP,PHP_C
MMS3_k127_3586181_0	439481.Aboo_0094	8.391e-162	538.0	COG0143@1|root,arCOG00810@2157|Archaea,2XTG5@28890|Euryarchaeota,3F2F7@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF692.Mbar_A0543	Anticodon_1,tRNA-synt_1g,tRNA_bind
MMS3_k127_3586181_1	1089551.KE386572_gene1878	1.174e-85	293.0	COG1351@1|root,COG1351@2|Bacteria,1MWY8@1224|Proteobacteria,2TTER@28211|Alphaproteobacteria,4BRKK@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant	thyX	-	2.1.1.148	ko:K03465	ko00240,ko00670,ko01100,map00240,map00670,map01100	-	R06613	RC00022,RC00332	ko00000,ko00001,ko01000	-	-	-	Thy1
MMS3_k127_3586181_2	797114.C475_20423	1.321e-37	155.0	COG0665@1|root,arCOG00755@2157|Archaea,2XT53@28890|Euryarchaeota,23TQC@183963|Halobacteria	183963|Halobacteria	E	COG0665 Glycine D-amino acid oxidases (deaminating)	soxB	-	1.5.3.1	ko:K00303	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO
MMS3_k127_3624609_12	1236689.MMALV_07510	1.394e-14	76.0	COG1602@1|root,arCOG04269@2157|Archaea,2XTEQ@28890|Euryarchaeota,3F34R@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Archaeal Nre, N-terminal	nreA	-	-	-	-	-	-	-	-	-	-	-	Nre_C,Nre_N
MMS3_k127_3624609_1	1267534.KB906756_gene433	2.851e-156	515.0	COG0160@1|root,COG0160@2|Bacteria,3Y4EV@57723|Acidobacteria,2JKID@204432|Acidobacteriia	204432|Acidobacteriia	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.55	ko:K15372	ko00410,ko00430,ko01100,map00410,map00430,map01100	-	R00908,R01684	RC00006,RC00062	ko00000,ko00001,ko01000	-	-	-	Aminotran_3
MMS3_k127_3624609_7	66897.DJ64_17710	1.156e-25	115.0	COG0491@1|root,COG0491@2|Bacteria,2H8JM@201174|Actinobacteria	201174|Actinobacteria	S	COG0491 Zn-dependent hydrolases, including glyoxylases	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
MMS3_k127_3624609_14	1136417.AZWE01000008_gene2196	1.845e-09	69.0	COG0346@1|root,COG0346@2|Bacteria,2IHYP@201174|Actinobacteria,4DFEH@85008|Micromonosporales	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
MMS3_k127_3624609_4	1235457.C404_19775	6.667e-60	224.0	COG2141@1|root,COG2141@2|Bacteria,1NXIH@1224|Proteobacteria,2VMHG@28216|Betaproteobacteria,1KGJA@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
MMS3_k127_3624609_6	472759.Nhal_2212	5.292e-31	132.0	COG1051@1|root,COG1051@2|Bacteria	2|Bacteria	F	GDP-mannose mannosyl hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
MMS3_k127_3624609_13	43989.cce_0616	4.308e-11	73.0	COG2227@1|root,COG2227@2|Bacteria,1GB2S@1117|Cyanobacteria,3KJPY@43988|Cyanothece	1117|Cyanobacteria	H	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23
MMS3_k127_3624609_8	358681.BBR47_09460	1.77e-20	96.0	COG3832@1|root,COG3832@2|Bacteria,1V8GQ@1239|Firmicutes,4HINK@91061|Bacilli,26Y9D@186822|Paenibacillaceae	91061|Bacilli	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
MMS3_k127_3624609_9	224324.aq_402	4.809e-19	97.0	COG0509@1|root,COG0509@2|Bacteria	2|Bacteria	E	glycine decarboxylation via glycine cleavage system	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
MMS3_k127_3624609_2	1459636.NTE_01352	1.258e-116	381.0	COG2897@1|root,arCOG02019@2157|Archaea,41SZQ@651137|Thaumarchaeota	651137|Thaumarchaeota	P	Rhodanese Homology Domain	-	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
MMS3_k127_3624609_11	1293047.CBMA010000023_gene1241	6.051e-15	78.0	COG0023@1|root,arCOG04223@2157|Archaea,2XY7H@28890|Euryarchaeota,23XRP@183963|Halobacteria	183963|Halobacteria	J	COG0023 Translation initiation factor 1 (eIF-1 SUI1) and related proteins	tif1b	-	-	ko:K03113	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	SUI1
MMS3_k127_3624609_17	985053.VMUT_1906	3.192e-05	56.0	COG0842@1|root,arCOG01468@2157|Archaea,2XRFD@28889|Crenarchaeota	28889|Crenarchaeota	V	ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
MMS3_k127_3624609_15	330779.Saci_2303	4.658e-08	63.0	COG0842@1|root,arCOG01469@2157|Archaea,2XRBH@28889|Crenarchaeota	28889|Crenarchaeota	P	ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
MMS3_k127_3624609_3	1459636.NTE_02001	9.799e-67	238.0	COG1131@1|root,arCOG00194@2157|Archaea	2157|Archaea	V	ABC-type multidrug transport system ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
MMS3_k127_3624609_16	1457393.AZ09_09920	3.31e-06	54.0	COG0346@1|root,COG0346@2|Bacteria,1RI06@1224|Proteobacteria,2U77N@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Lactoylglutathione lyase	lguL	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
MMS3_k127_3624609_0	1379698.RBG1_1C00001G0054	2.168e-171	545.0	COG2502@1|root,COG2502@2|Bacteria,2NNKP@2323|unclassified Bacteria	2|Bacteria	E	Aspartate-ammonia ligase	asnA	GO:0003674,GO:0003824,GO:0004071,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006528,GO:0006529,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009987,GO:0016053,GO:0016211,GO:0016874,GO:0016879,GO:0016880,GO:0019752,GO:0032787,GO:0033554,GO:0034641,GO:0042802,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0050896,GO:0051716,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.1.1	ko:K01914	ko00250,ko00460,ko01100,ko01110,ko01230,map00250,map00460,map01100,map01110,map01230	-	R00483	RC00010	ko00000,ko00001,ko01000	-	-	iAPECO1_1312.APECO1_2719,iECOK1_1307.ECOK1_4193,iECS88_1305.ECS88_4166,iUMN146_1321.UM146_18910,iUTI89_1310.UTI89_C4299	AsnA
MMS3_k127_3624609_5	273116.14325461	2.286e-41	163.0	COG4275@1|root,arCOG10427@2157|Archaea,2XXPQ@28890|Euryarchaeota	28890|Euryarchaeota	S	Chromate resistance	-	-	-	-	-	-	-	-	-	-	-	-	Chrome_Resist
MMS3_k127_3624609_10	1445613.JALM01000035_gene421	1.886e-17	96.0	COG1718@1|root,COG1718@2|Bacteria,2GM3J@201174|Actinobacteria,4DZAA@85010|Pseudonocardiales	201174|Actinobacteria	DT	RIO1 family	-	-	2.7.11.1	ko:K07178	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko01001,ko03009	-	-	-	RIO1
MMS3_k127_3642342_4	670487.Ocepr_2189	4.784e-20	92.0	COG0182@1|root,COG0182@2|Bacteria,1WI3U@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	mtnA	-	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	-	IF-2B
MMS3_k127_3642342_1	511051.CSE_07990	1.478e-108	364.0	COG0205@1|root,COG0205@2|Bacteria	2|Bacteria	G	6-phosphofructokinase activity	pfkA	-	2.7.1.11,2.7.1.90	ko:K00850,ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R00764,R02073,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	iJN678.pfkA	PFK
MMS3_k127_3642342_3	673860.AciM339_0595	5.223e-79	280.0	COG0006@1|root,arCOG01000@2157|Archaea,2XTI9@28890|Euryarchaeota,3F2JJ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	E	Belongs to the peptidase M24B family	pepQ1	-	3.4.13.9	ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
MMS3_k127_3642342_0	1151117.AJLF01000001_gene1051	1.916e-152	512.0	COG1003@1|root,arCOG00076@2157|Archaea,2XT3V@28890|Euryarchaeota,242MV@183968|Thermococci	183968|Thermococci	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPB	-	1.4.4.2	ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
MMS3_k127_3642342_2	673860.AciM339_0362	3.559e-98	337.0	COG0403@1|root,arCOG00077@2157|Archaea,2XT39@28890|Euryarchaeota,3F362@33867|unclassified Euryarchaeota	28890|Euryarchaeota	E	Glycine cleavage system P-protein	gcvPA	-	1.4.4.2	ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
MMS3_k127_3684029_4	1089550.ATTH01000001_gene162	2.411e-155	504.0	COG0364@1|root,COG0364@2|Bacteria,4NE59@976|Bacteroidetes,1FIS5@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	zwf	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
MMS3_k127_3684029_5	1205753.A989_00665	6.147e-128	415.0	COG1023@1|root,COG1023@2|Bacteria,1QU14@1224|Proteobacteria,1T1KM@1236|Gammaproteobacteria,1X4EG@135614|Xanthomonadales	135614|Xanthomonadales	G	6-phosphogluconate dehydrogenase	gnd	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
MMS3_k127_3684029_10	319795.Dgeo_1667	4.71e-52	192.0	COG1011@1|root,COG1011@2|Bacteria	2|Bacteria	S	phosphatase activity	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
MMS3_k127_3684029_0	309807.SRU_0080	7.934e-277	904.0	COG0166@1|root,COG0176@1|root,COG0166@2|Bacteria,COG0176@2|Bacteria,4NDWV@976|Bacteroidetes,1FJJA@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	G	Phosphoglucose isomerase	tal	-	2.2.1.2,5.3.1.9	ko:K00616,ko:K13810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00004,M00007,M00114	R01827,R02739,R02740,R03321	RC00376,RC00439,RC00563,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	PGI,TAL_FSA
MMS3_k127_3684029_1	666685.R2APBS1_3911	4.282e-249	795.0	COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,1SJQ1@1236|Gammaproteobacteria,1X5IA@135614|Xanthomonadales	135614|Xanthomonadales	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
MMS3_k127_3684029_7	1121918.ARWE01000001_gene3112	2.928e-65	244.0	COG1940@1|root,COG1940@2|Bacteria,1MU94@1224|Proteobacteria,42RF4@68525|delta/epsilon subdivisions,2WPIV@28221|Deltaproteobacteria,43TWB@69541|Desulfuromonadales	28221|Deltaproteobacteria	GK	PFAM ROK family protein	glkA	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
MMS3_k127_3684029_9	1120985.AUMI01000018_gene3018	1.616e-58	213.0	COG0652@1|root,COG0652@2|Bacteria,1TRHW@1239|Firmicutes,4H408@909932|Negativicutes	909932|Negativicutes	M	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	-	-	5.2.1.8	ko:K03767	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Pro_isomerase
MMS3_k127_3684029_13	1104324.P186_0110	2.716e-24	118.0	COG0328@1|root,arCOG02942@2157|Archaea,2XR72@28889|Crenarchaeota	28889|Crenarchaeota	L	Reverse transcriptase-like	rnhA	-	3.1.26.4	ko:K03469	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RVT_3
MMS3_k127_3684029_2	56780.SYN_02218	1.465e-210	684.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2WIU0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
MMS3_k127_3684029_15	1121127.JAFA01000010_gene3932	1.688e-19	100.0	COG0517@1|root,COG0517@2|Bacteria,1RE9W@1224|Proteobacteria,2VRIH@28216|Betaproteobacteria,1K4C0@119060|Burkholderiaceae	28216|Betaproteobacteria	S	PFAM CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	BON,CBS
MMS3_k127_3684029_17	266835.14026270	7.998e-16	85.0	COG0517@1|root,COG2823@1|root,COG0517@2|Bacteria,COG2823@2|Bacteria,1NY5H@1224|Proteobacteria,2U1GG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	BON,CBS
MMS3_k127_3684029_14	443144.GM21_0684	2.385e-21	108.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42P5K@68525|delta/epsilon subdivisions,2WMEF@28221|Deltaproteobacteria,43TIX@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
MMS3_k127_3684029_11	1209072.ALBT01000026_gene3692	7.393e-48	194.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,1T30G@1236|Gammaproteobacteria,1FFSS@10|Cellvibrio	1236|Gammaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS
MMS3_k127_3684029_3	186497.PF0547	1.969e-164	528.0	COG2403@1|root,arCOG01229@2157|Archaea,2XVYH@28890|Euryarchaeota,24343@183968|Thermococci	183968|Thermococci	S	CobW/HypB/UreG, nucleotide-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cobW
MMS3_k127_3684029_8	387631.Asulf_01959	1.538e-60	224.0	COG0025@1|root,arCOG01961@2157|Archaea,2XVSR@28890|Euryarchaeota,246UN@183980|Archaeoglobi	183980|Archaeoglobi	P	NhaP-type Na H and K H	-	-	-	ko:K03316	-	-	-	-	ko00000	2.A.36	-	-	Na_H_Exchanger
MMS3_k127_3684029_16	1300345.LF41_1458	3.46e-18	98.0	COG2309@1|root,COG2309@2|Bacteria	2|Bacteria	E	aminopeptidase activity	-	-	-	ko:K19689	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	HTH_20,Peptidase_M29
MMS3_k127_3684029_6	273063.STK_10340	1.128e-65	234.0	COG1131@1|root,arCOG00194@2157|Archaea	2157|Archaea	V	ABC-type multidrug transport system ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
MMS3_k127_3684029_12	386456.JQKN01000017_gene841	1.329e-39	162.0	arCOG12322@1|root,arCOG12322@2157|Archaea,2Y5I1@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_3689316_1	1121377.KB906402_gene3252	9.675e-27	115.0	COG2987@1|root,COG2987@2|Bacteria,1WJ22@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate	hutU	-	4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000	-	-	-	Urocanase,Urocanase_C,Urocanase_N
MMS3_k127_3689316_0	1121920.AUAU01000002_gene2088	3.095e-33	145.0	COG1252@1|root,COG1252@2|Bacteria,3Y308@57723|Acidobacteria	57723|Acidobacteria	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
MMS3_k127_3689316_2	290397.Adeh_1894	1.635e-11	70.0	COG3360@1|root,COG3360@2|Bacteria,1N6UT@1224|Proteobacteria,42XUW@68525|delta/epsilon subdivisions,2WSV8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Dodecin	-	-	-	ko:K09165	-	-	-	-	ko00000	-	-	-	Dodecin
MMS3_k127_3699108_11	644968.DFW101_2097	5.984e-20	95.0	COG0438@1|root,COG0438@2|Bacteria,1RH5W@1224|Proteobacteria,42UY3@68525|delta/epsilon subdivisions,2WQ9B@28221|Deltaproteobacteria,2MA2D@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
MMS3_k127_3699108_5	1382306.JNIM01000001_gene1564	1.779e-47	191.0	COG0284@1|root,COG0284@2|Bacteria,2G692@200795|Chloroflexi	200795|Chloroflexi	F	Belongs to the OMP decarboxylase family. Type 2 subfamily	pyrF	GO:0003674,GO:0003824,GO:0004590,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.4.2.10,4.1.1.23	ko:K01591,ko:K13421	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00051	R00965,R01870,R08231	RC00063,RC00409,RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
MMS3_k127_3699108_3	1227484.C471_12981	1.316e-48	192.0	COG1599@1|root,arCOG01510@2157|Archaea,2XTGJ@28890|Euryarchaeota,23RXQ@183963|Halobacteria	183963|Halobacteria	L	COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins	rpa1	-	-	ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko03000,ko03032,ko03400	-	-	-	-
MMS3_k127_3699108_10	1041930.Mtc_0017	5.212e-21	107.0	COG3390@1|root,arCOG02257@2157|Archaea,2XTM4@28890|Euryarchaeota,2N9JC@224756|Methanomicrobia	224756|Methanomicrobia	S	protein conserved in archaea	-	-	-	ko:K09746	-	-	-	-	ko00000	-	-	-	-
MMS3_k127_3699108_9	673860.AciM339_1566	2.568e-24	114.0	COG1047@1|root,arCOG00981@2157|Archaea,2Y6YB@28890|Euryarchaeota,3F2VV@33867|unclassified Euryarchaeota	28890|Euryarchaeota	O	FKBP-type peptidyl-prolyl cis-trans isomerase	-	-	-	-	-	-	-	-	-	-	-	-	FKBP_C
MMS3_k127_3699108_12	1206739.BAGJ01000136_gene6377	4.138e-08	66.0	COG0500@1|root,COG2226@2|Bacteria,2I2JW@201174|Actinobacteria,4G9F0@85025|Nocardiaceae	201174|Actinobacteria	Q	Thiopurine S-methyltransferase (TPMT)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
MMS3_k127_3699108_6	679926.Mpet_2372	6.484e-40	171.0	COG1691@1|root,arCOG02465@2157|Archaea,2XTIH@28890|Euryarchaeota,2N9MD@224756|Methanomicrobia	224756|Methanomicrobia	S	AIR carboxylase	-	-	-	ko:K06898	-	-	-	-	ko00000	-	-	-	AIRC
MMS3_k127_3699108_0	1242864.D187_000415	3.236e-132	445.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42MK5@68525|delta/epsilon subdivisions,2WJ3Z@28221|Deltaproteobacteria,2YUET@29|Myxococcales	28221|Deltaproteobacteria	C	Acyl-CoA dehydrogenase, N-terminal domain	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
MMS3_k127_3699108_7	706587.Desti_4022	1.674e-37	151.0	COG2086@1|root,COG2086@2|Bacteria,1MVH6@1224|Proteobacteria,42RCI@68525|delta/epsilon subdivisions,2WMYC@28221|Deltaproteobacteria,2MQGX@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Electron transfer flavoprotein domain	etfB	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
MMS3_k127_3699108_4	1125863.JAFN01000001_gene1228	1.495e-48	196.0	COG2025@1|root,COG2025@2|Bacteria,1MUFI@1224|Proteobacteria,42M3T@68525|delta/epsilon subdivisions,2WIV8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	electron transfer flavoprotein, alpha subunit	-	-	-	-	-	-	-	-	-	-	-	-	ETF,ETF_alpha
MMS3_k127_3699108_13	1283283.ATXA01000007_gene3792	5.37e-08	63.0	COG3428@1|root,COG3428@2|Bacteria,2GK6Y@201174|Actinobacteria,4EVYI@85013|Frankiales	201174|Actinobacteria	S	Bacterial PH domain	-	-	-	-	-	-	-	-	-	-	-	-	bPH_2
MMS3_k127_3699108_1	861299.J421_5582	2.213e-73	257.0	COG2159@1|root,COG2159@2|Bacteria	2|Bacteria	E	amidohydrolase	bamU	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
MMS3_k127_3699108_8	673860.AciM339_1234	8e-34	135.0	COG0361@1|root,arCOG01179@2157|Archaea,2XXX0@28890|Euryarchaeota,3F2RM@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits	eif1a	-	-	ko:K03236	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	eIF-1a
MMS3_k127_3699108_2	1054217.TALC_00337	7.466e-65	239.0	COG0063@1|root,arCOG00018@2157|Archaea,2XU4W@28890|Euryarchaeota,241NJ@183967|Thermoplasmata	183967|Thermoplasmata	G	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
MMS3_k127_3757290_6	1380763.BG53_12310	3.734e-08	62.0	COG0346@1|root,COG0346@2|Bacteria,1V4S3@1239|Firmicutes,4HIIR@91061|Bacilli,275F7@186822|Paenibacillaceae	91061|Bacilli	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	yetH	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
MMS3_k127_3757290_5	797210.Halxa_2157	1.827e-11	72.0	COG3815@1|root,arCOG03949@2157|Archaea,2XZ2C@28890|Euryarchaeota,23X0I@183963|Halobacteria	183963|Halobacteria	S	Predicted membrane protein (DUF2085)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2085
MMS3_k127_3757290_4	765420.OSCT_0910	8.792e-12	79.0	COG0457@1|root,COG1716@1|root,COG4447@1|root,COG0457@2|Bacteria,COG1716@2|Bacteria,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	CarboxypepD_reg,FHA,Kelch_4,NHL,PA14,Peptidase_C11
MMS3_k127_3757290_1	323259.Mhun_2840	2.006e-20	108.0	COG3291@1|root,arCOG02516@1|root,arCOG03264@1|root,arCOG03606@1|root,arCOG02510@2157|Archaea,arCOG02516@2157|Archaea,arCOG03264@2157|Archaea,arCOG03606@2157|Archaea,2Y7RP@28890|Euryarchaeota,2NBKZ@224756|Methanomicrobia	224756|Methanomicrobia	S	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,DUF3344,PKD
MMS3_k127_3757290_0	933801.Ahos_0164	4.393e-21	109.0	COG3391@1|root,arCOG06052@1|root,arCOG02560@2157|Archaea,arCOG06052@2157|Archaea,2XRYP@28889|Crenarchaeota	28889|Crenarchaeota	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_3757290_3	1198114.AciX9_2489	1.185e-14	88.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	wcoG	-	-	-	-	-	-	-	-	-	-	-	DUF5122,Laminin_G_3,PKD
MMS3_k127_3757290_2	1192034.CAP_0215	3.968e-18	100.0	COG1376@1|root,COG1376@2|Bacteria	2|Bacteria	D	ErfK ybiS ycfS ynhG family protein	enhA_1	-	-	-	-	-	-	-	-	-	-	-	PG_binding_4,YkuD
MMS3_k127_3778992_4	1125863.JAFN01000001_gene747	4.044e-32	132.0	COG0500@1|root,COG2226@2|Bacteria,1MX8I@1224|Proteobacteria,42P2Z@68525|delta/epsilon subdivisions,2WNJ6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)	ubiE	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
MMS3_k127_3778992_1	868131.MSWAN_1773	7.595e-87	308.0	COG0436@1|root,arCOG04897@2157|Archaea,2XURI@28890|Euryarchaeota,23NXC@183925|Methanobacteria	183925|Methanobacteria	E	PFAM Aminotransferase, class I	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
MMS3_k127_3778992_3	593117.TGAM_0679	1.465e-43	179.0	COG2520@1|root,arCOG10124@2157|Archaea,2XTPV@28890|Euryarchaeota,243G1@183968|Thermococci	183968|Thermococci	J	S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe)	taw2	GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360	2.5.1.114	ko:K07055	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Met_10
MMS3_k127_3778992_2	439481.Aboo_1535	4.184e-53	212.0	COG1378@1|root,arCOG02038@2157|Archaea,2Y7FZ@28890|Euryarchaeota,3F2ZR@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	Archaeal transcriptional regulator TrmB	-	-	-	-	-	-	-	-	-	-	-	-	Regulator_TrmB,TrmB
MMS3_k127_3778992_0	386456.JQKN01000011_gene732	9.276e-136	446.0	COG1027@1|root,arCOG01750@2157|Archaea,2Y84P@28890|Euryarchaeota	28890|Euryarchaeota	E	Fumarase C C-terminus	-	-	4.2.1.2,4.3.1.1	ko:K01679,ko:K01744	ko00020,ko00250,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00250,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R00490,R01082	RC00316,RC00443,RC02799	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
MMS3_k127_3778992_5	694440.JOMF01000004_gene1270	4.446e-05	56.0	COG4089@1|root,arCOG02159@2157|Archaea,2XY93@28890|Euryarchaeota,2N9R2@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF1614)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1614
MMS3_k127_3802490_8	408672.NBCG_04146	0.000607	47.0	COG0389@1|root,COG0389@2|Bacteria,2GKBI@201174|Actinobacteria,4DN0X@85009|Propionibacteriales	201174|Actinobacteria	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	HHH_5,IMS,IMS_C,IMS_HHH
MMS3_k127_3802490_4	309801.trd_A0745	1.172e-36	157.0	COG1524@1|root,COG1524@2|Bacteria,2G5RJ@200795|Chloroflexi,27Y31@189775|Thermomicrobia	189775|Thermomicrobia	S	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
MMS3_k127_3802490_0	439481.Aboo_0942	5.248e-150	496.0	COG0532@1|root,arCOG01560@2157|Archaea,2XU09@28890|Euryarchaeota,3F2FJ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2	infB	-	-	ko:K03243	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D4,IF-2,Intein_splicing,LAGLIDADG_3
MMS3_k127_3802490_5	69014.TK1280	1.006e-34	145.0	COG1405@1|root,arCOG01981@2157|Archaea,2XT0Z@28890|Euryarchaeota,242MH@183968|Thermococci	183968|Thermococci	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	tfb	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
MMS3_k127_3802490_2	525904.Tter_0750	7.563e-65	238.0	COG0123@1|root,COG0123@2|Bacteria,2NP8V@2323|unclassified Bacteria	2|Bacteria	BQ	Histone deacetylase domain	-	-	-	ko:K04768	-	-	-	-	ko00000	-	-	-	Hist_deacetyl
MMS3_k127_3802490_7	1042877.GQS_09785	5.832e-16	90.0	COG2309@1|root,arCOG01890@2157|Archaea,2XU28@28890|Euryarchaeota,243WP@183968|Thermococci	183968|Thermococci	E	Thermophilic metalloprotease (M29)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M29
MMS3_k127_3802490_6	1114856.C496_18313	1.534e-21	104.0	arCOG02274@1|root,arCOG02274@2157|Archaea,2XVHG@28890|Euryarchaeota,23SZN@183963|Halobacteria	183963|Halobacteria	K	DNA binding protein	-	-	-	ko:K06930	-	-	-	-	ko00000	-	-	-	HTH_10
MMS3_k127_3802490_1	1408418.JNJH01000006_gene1284	4.845e-77	271.0	COG0306@1|root,COG0306@2|Bacteria	2|Bacteria	P	phosphate transporter	cysP	GO:0003674,GO:0005215,GO:0005315,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0015291,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0035435,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661	-	ko:K03306,ko:K16331	-	-	-	-	ko00000,ko02000	2.A.20,2.A.20.4	-	-	PHO4
MMS3_k127_3802490_3	395961.Cyan7425_1835	3.536e-47	185.0	COG1748@1|root,COG1748@2|Bacteria,1G37A@1117|Cyanobacteria	1117|Cyanobacteria	E	Saccharopine dehydrogenase C-terminal domain	-	-	1.5.1.7	ko:K00290	ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230	M00030,M00032	R00715	RC00217,RC01532	ko00000,ko00001,ko00002,ko01000	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP
MMS3_k127_3806081_0	861299.J421_3546	2.513e-126	428.0	COG2986@1|root,COG2986@2|Bacteria,1ZTEG@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Aromatic amino acid lyase	hutH	-	4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
MMS3_k127_3806081_1	926569.ANT_02490	6.002e-37	151.0	293MU@1|root,2ZR3M@2|Bacteria	2|Bacteria	S	Nickel-containing superoxide dismutase	sodN	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	1.15.1.1	ko:K00518	-	-	-	-	ko00000,ko01000	-	-	-	Sod_Ni
MMS3_k127_3806081_5	935863.AWZR01000013_gene1451	8.82e-12	72.0	COG0681@1|root,COG0681@2|Bacteria,1R7Z4@1224|Proteobacteria,1RX6N@1236|Gammaproteobacteria,1XD4B@135614|Xanthomonadales	135614|Xanthomonadales	U	Signal peptidase, peptidase S26	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S24
MMS3_k127_3806081_4	429009.Adeg_0640	1.049e-18	98.0	COG0725@1|root,COG0725@2|Bacteria,1V2FD@1239|Firmicutes,24CFB@186801|Clostridia,42I7Z@68295|Thermoanaerobacterales	186801|Clostridia	P	extracellular solute-binding protein, family 1	-	-	-	ko:K15495	ko02010,map02010	M00423	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.5	-	-	SBP_bac_11
MMS3_k127_3806081_2	429009.Adeg_0641	3.735e-32	142.0	COG0555@1|root,COG0555@2|Bacteria,1TQHR@1239|Firmicutes,24ACM@186801|Clostridia,42J4B@68295|Thermoanaerobacterales	186801|Clostridia	P	PFAM binding-protein-dependent transport systems inner membrane component	cysT	-	-	ko:K02046,ko:K15496	ko00920,ko02010,map00920,map02010	M00185,M00423	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.1,3.A.1.6.3,3.A.1.6.5	-	-	BPD_transp_1
MMS3_k127_3806081_3	1429046.RR21198_4363	2.539e-27	128.0	COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria,4FV1V@85025|Nocardiaceae	201174|Actinobacteria	P	Part of the ABC transporter complex FbpABC involved in Fe(3 ) ions import. Responsible for energy coupling to the transport system	fbpC	-	3.6.3.30	ko:K02010	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10	-	-	ABC_tran,TOBE_2
MMS3_k127_3808652_1	439481.Aboo_0716	3.258e-57	203.0	COG0467@1|root,arCOG01171@2157|Archaea,2XTU3@28890|Euryarchaeota,3F31P@33867|unclassified Euryarchaeota	28890|Euryarchaeota	T	Rad51	-	-	-	-	-	-	-	-	-	-	-	-	ATPase
MMS3_k127_3808652_4	439481.Aboo_0715	2.337e-27	118.0	arCOG02452@1|root,arCOG02452@2157|Archaea,2Y71S@28890|Euryarchaeota,3F36K@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	COG0467 RecA-superfamily ATPases implicated in signal transduction	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_3808652_3	439481.Aboo_0714	2.576e-37	160.0	COG0467@1|root,arCOG01171@2157|Archaea,2Y69G@28890|Euryarchaeota,3F39I@33867|unclassified Euryarchaeota	28890|Euryarchaeota	T	Pfam:KaiC	-	-	-	-	-	-	-	-	-	-	-	-	ATPase
MMS3_k127_3808652_0	673860.AciM339_1477	2.613e-73	255.0	COG2047@1|root,arCOG00348@2157|Archaea,2XSX4@28890|Euryarchaeota,3F2K5@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	PAC2 family	-	-	-	ko:K07159	-	-	-	-	ko00000	-	-	-	PAC2
MMS3_k127_3808652_2	478741.JAFS01000001_gene1269	2.619e-41	176.0	COG1565@1|root,COG1565@2|Bacteria,46T7F@74201|Verrucomicrobia,37GK5@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	S	Putative S-adenosyl-L-methionine-dependent methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_28
MMS3_k127_3826259_6	1068978.AMETH_3897	2.2e-77	272.0	COG4948@1|root,COG4948@2|Bacteria,2GJJR@201174|Actinobacteria,4E02U@85010|Pseudonocardiales	201174|Actinobacteria	H	Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB)	menC	-	4.2.1.113,5.5.1.1	ko:K01856,ko:K02549	ko00130,ko00361,ko00362,ko00364,ko00623,ko01100,ko01110,ko01120,ko01220,map00130,map00361,map00362,map00364,map00623,map01100,map01110,map01120,map01220	M00116,M00568	R04031,R05300,R05390,R06989,R08116,R09229	RC00903,RC01038,RC01053,RC01108,RC01321,RC01356	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
MMS3_k127_3826259_15	368408.Tpen_1785	3.391e-52	195.0	COG3375@1|root,arCOG04215@2157|Archaea,2XQCZ@28889|Crenarchaeota	28889|Crenarchaeota	M	carboxylic acid catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
MMS3_k127_3826259_17	584708.Apau_1586	2.353e-45	175.0	COG2519@1|root,COG2519@2|Bacteria,3TA8U@508458|Synergistetes	508458|Synergistetes	J	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA	-	-	2.1.1.219,2.1.1.220	ko:K07442	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	GCD14
MMS3_k127_3826259_26	679926.Mpet_1097	3.384e-13	76.0	COG1733@1|root,arCOG01057@2157|Archaea	2157|Archaea	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
MMS3_k127_3826259_9	981369.JQMJ01000004_gene2294	1.325e-72	268.0	COG0477@1|root,COG1846@1|root,COG0477@2|Bacteria,COG1846@2|Bacteria,2GJ09@201174|Actinobacteria,2NHDQ@228398|Streptacidiphilus	201174|Actinobacteria	EGKP	Fungal trichothecene efflux pump (TRI12)	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS3_k127_3826259_8	671065.MetMK1DRAFT_00026040	6.927e-76	270.0	COG0475@1|root,arCOG01953@2157|Archaea,2XQYM@28889|Crenarchaeota	28889|Crenarchaeota	P	PFAM sodium hydrogen exchanger	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
MMS3_k127_3826259_20	1124780.ANNU01000048_gene2139	3.194e-35	149.0	COG1226@1|root,COG1226@2|Bacteria,4NMSS@976|Bacteroidetes	976|Bacteroidetes	P	TrkA-N domain	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2,TrkA_N
MMS3_k127_3826259_25	439481.Aboo_0929	6.756e-14	78.0	COG1758@1|root,arCOG01268@2157|Archaea,2XZSW@28890|Euryarchaeota,3F2TZ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoK	-	2.7.7.6	ko:K03055	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb6
MMS3_k127_3826259_3	673860.AciM339_0357	9.355e-85	295.0	COG0005@1|root,arCOG01327@2157|Archaea,2XUJX@28890|Euryarchaeota,3F2GH@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	Purine nucleoside phosphorylase involved in purine salvage	mtnP	-	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
MMS3_k127_3826259_21	673860.AciM339_0975	1.19e-22	106.0	COG2178@1|root,arCOG04318@2157|Archaea,2XYD0@28890|Euryarchaeota,3F2TB@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	RNA-binding protein of the translin family	-	-	-	ko:K07477	-	-	-	-	ko00000	-	-	-	Translin
MMS3_k127_3826259_23	573063.Metin_0008	1.326e-15	88.0	COG1849@1|root,arCOG01224@2157|Archaea,2XYS0@28890|Euryarchaeota,23R2G@183939|Methanococci	183939|Methanococci	S	Protein of unknown function (DUF357)	-	-	-	ko:K09728	-	-	-	-	ko00000	-	-	-	DUF357
MMS3_k127_3826259_4	378806.STAUR_6590	3.88e-83	281.0	COG0176@1|root,COG0176@2|Bacteria,1MWQ8@1224|Proteobacteria,42M39@68525|delta/epsilon subdivisions,2WJEZ@28221|Deltaproteobacteria,2YTW3@29|Myxococcales	28221|Deltaproteobacteria	F	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
MMS3_k127_3826259_19	335541.Swol_0244	4.835e-42	168.0	COG3958@1|root,COG3958@2|Bacteria,1V0K5@1239|Firmicutes,24914@186801|Clostridia,42KDR@68298|Syntrophomonadaceae	186801|Clostridia	G	Transketolase, pyrimidine binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
MMS3_k127_3826259_10	479434.Sthe_1657	2.569e-69	247.0	COG0648@1|root,COG0648@2|Bacteria,2G5XZ@200795|Chloroflexi,27XEG@189775|Thermomicrobia	189775|Thermomicrobia	L	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin	nfo	-	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
MMS3_k127_3826259_27	1007103.AFHW01000088_gene2646	8.784e-09	67.0	COG2050@1|root,COG2050@2|Bacteria,1V8GT@1239|Firmicutes,4HJ7K@91061|Bacilli,276KY@186822|Paenibacillaceae	91061|Bacilli	Q	Domain of unknown function (DUF4442)	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
MMS3_k127_3826259_14	666685.R2APBS1_3945	8.929e-58	217.0	COG3407@1|root,COG3407@2|Bacteria,1N5EZ@1224|Proteobacteria,1S19T@1236|Gammaproteobacteria,1X9HF@135614|Xanthomonadales	135614|Xanthomonadales	I	GHMP kinases N terminal domain	-	-	4.1.1.33	ko:K01597	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00095	R01121	RC00453	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_N
MMS3_k127_3826259_7	330779.Saci_1771	8.573e-77	270.0	COG3396@1|root,arCOG04786@2157|Archaea	2157|Archaea	S	Phenylacetate-CoA oxygenase	paaA	-	1.14.13.149	ko:K02609	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001,ko01000	-	-	-	PaaA_PaaC
MMS3_k127_3826259_5	1379698.RBG1_1C00001G0806	6.228e-78	275.0	COG1024@1|root,COG1024@2|Bacteria,2NPAC@2323|unclassified Bacteria	2|Bacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	-	ECH_1
MMS3_k127_3826259_18	324602.Caur_3198	2.812e-44	177.0	COG0120@1|root,COG0120@2|Bacteria,2G6NN@200795|Chloroflexi,377B7@32061|Chloroflexia	32061|Chloroflexia	F	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate	rpiA	-	5.3.1.6	ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167,M00580	R01056	RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	Rib_5-P_isom_A
MMS3_k127_3826259_16	1054217.TALC_01301	1.739e-45	182.0	COG0528@1|root,arCOG00858@2157|Archaea,2XT3U@28890|Euryarchaeota,241S5@183967|Thermoplasmata	183967|Thermoplasmata	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
MMS3_k127_3826259_12	644966.Tmar_2275	4.267e-62	220.0	COG0563@1|root,COG0563@2|Bacteria,1TP27@1239|Firmicutes,247YN@186801|Clostridia,3WCG7@538999|Clostridiales incertae sedis	186801|Clostridia	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iHN637.CLJU_RS20110	ADK,ADK_lid
MMS3_k127_3826259_29	391596.PBAL39_04338	1.884e-05	56.0	COG1361@1|root,COG3420@1|root,COG3534@1|root,COG1361@2|Bacteria,COG3420@2|Bacteria,COG3534@2|Bacteria,4NMB8@976|Bacteroidetes,1J0GS@117747|Sphingobacteriia	976|Bacteroidetes	M	Conserved repeat domain	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,DUF11,Laminin_G_3,MAM,SdrD_B
MMS3_k127_3826259_24	477974.Daud_1575	4.513e-15	81.0	COG4747@1|root,COG4747@2|Bacteria,1V7U2@1239|Firmicutes,24JE5@186801|Clostridia,2629K@186807|Peptococcaceae	186801|Clostridia	S	PFAM Amino acid-binding ACT	-	-	-	-	-	-	-	-	-	-	-	-	ACT
MMS3_k127_3826259_22	439481.Aboo_0005	2.513e-17	93.0	arCOG02911@1|root,arCOG02911@2157|Archaea,2Y701@28890|Euryarchaeota,3F31J@33867|unclassified Euryarchaeota	28890|Euryarchaeota	M	toxin activity	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_3826259_0	439481.Aboo_0006	1.176e-207	661.0	COG4962@1|root,arCOG01817@2157|Archaea,2XT4E@28890|Euryarchaeota,3F381@33867|unclassified Euryarchaeota	28890|Euryarchaeota	N	Type II/IV secretion system protein	-	-	-	ko:K07332	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
MMS3_k127_3826259_13	439481.Aboo_0007	3.9e-61	223.0	COG2064@1|root,arCOG01808@2157|Archaea,2XT4Q@28890|Euryarchaeota,3F36C@33867|unclassified Euryarchaeota	28890|Euryarchaeota	N	Type II secretion system	-	-	-	ko:K07333	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSF
MMS3_k127_3826259_11	439481.Aboo_0008	5.953e-69	245.0	COG2064@1|root,arCOG01808@2157|Archaea,2XT4Q@28890|Euryarchaeota,3F37F@33867|unclassified Euryarchaeota	28890|Euryarchaeota	N	Type II secretion system	-	-	-	ko:K07333	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSF
MMS3_k127_3826259_1	439481.Aboo_0009	1.386e-206	673.0	COG4962@1|root,arCOG01817@2157|Archaea,2XT4E@28890|Euryarchaeota,3F2TI@33867|unclassified Euryarchaeota	28890|Euryarchaeota	N	Type II/IV secretion system protein	-	-	-	ko:K07332	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
MMS3_k127_3826259_2	1459636.NTE_03263	5.656e-87	317.0	COG0863@1|root,arCOG00115@2157|Archaea	2157|Archaea	H	methylase	-	-	2.1.1.72	ko:K00571	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
MMS3_k127_3851940_4	592015.HMPREF1705_01410	4.074e-14	87.0	COG0624@1|root,COG0624@2|Bacteria,3TAG2@508458|Synergistetes	508458|Synergistetes	E	TIGRFAM acetylornithine deacetylase or	-	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
MMS3_k127_3851940_2	1197130.BAFM01000011_gene2065	2.083e-43	179.0	COG3356@1|root,arCOG04351@2157|Archaea,2XVEY@28890|Euryarchaeota,23S9F@183963|Halobacteria	183963|Halobacteria	S	membrane	-	-	-	ko:K08979	-	-	-	-	ko00000	-	-	-	DUF2070
MMS3_k127_3851940_1	555088.DealDRAFT_0223	1.315e-54	214.0	COG1646@1|root,COG1646@2|Bacteria	2|Bacteria	I	Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids	pcrB	GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:1901576	-	ko:K07094	-	-	-	-	ko00000,ko01000	-	-	-	PcrB
MMS3_k127_3851940_3	273116.14324962	2.243e-33	143.0	COG0382@1|root,arCOG00476@2157|Archaea,2XUHS@28890|Euryarchaeota,241QE@183967|Thermoplasmata	183967|Thermoplasmata	H	UbiA prenyltransferase family	-	-	2.5.1.42	ko:K17105	ko00564,map00564	-	R04520	RC01171	ko00000,ko00001,ko01000	-	-	-	UbiA
MMS3_k127_3851940_0	1382356.JQMP01000001_gene1193	1.167e-87	303.0	COG0612@1|root,COG0612@2|Bacteria,2G5N3@200795|Chloroflexi,27XVK@189775|Thermomicrobia	189775|Thermomicrobia	S	Insulinase (Peptidase family M16)	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
MMS3_k127_387483_5	263820.PTO0896	3.372e-34	135.0	COG0644@1|root,arCOG00570@2157|Archaea,2XU3J@28890|Euryarchaeota,241M8@183967|Thermoplasmata	183967|Thermoplasmata	C	Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains	-	-	1.3.1.101,1.3.7.11	ko:K17830	ko00564,map00564	-	R10325,R10326,R10331	RC03134	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3
MMS3_k127_387483_9	673860.AciM339_0467	3.879e-15	77.0	COG2768@1|root,arCOG02448@2157|Archaea,2Y7JX@28890|Euryarchaeota,3F2W9@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
MMS3_k127_387483_0	290318.Cvib_1011	1.52e-105	360.0	COG0492@1|root,COG0492@2|Bacteria,1FDM4@1090|Chlorobi	1090|Chlorobi	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
MMS3_k127_387483_7	1179773.BN6_55610	6.048e-22	103.0	COG1853@1|root,COG1853@2|Bacteria,2INYP@201174|Actinobacteria,4EEX2@85010|Pseudonocardiales	201174|Actinobacteria	S	Flavin reductase like domain	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
MMS3_k127_387483_4	443143.GM18_2743	1.14e-39	168.0	COG0842@1|root,COG0842@2|Bacteria,1Q99P@1224|Proteobacteria,42M53@68525|delta/epsilon subdivisions,2WMEY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane,ABC2_membrane_3
MMS3_k127_387483_1	386456.JQKN01000001_gene2139	1.365e-69	250.0	COG1131@1|root,arCOG00194@2157|Archaea,2XT1I@28890|Euryarchaeota	28890|Euryarchaeota	E	ABC-type multidrug transport system, ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
MMS3_k127_387483_8	272569.rrnAC2386	9.216e-19	100.0	arCOG01449@1|root,arCOG01449@2157|Archaea,2XSVU@28890|Euryarchaeota,23T0K@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Cas_Cas02710
MMS3_k127_387483_6	1335757.SPICUR_08815	1.93e-30	132.0	COG0685@1|root,COG0685@2|Bacteria,1QGEE@1224|Proteobacteria,1RSEG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	COG0685 5,10-methylenetetrahydrofolate reductase	-	-	-	-	-	-	-	-	-	-	-	-	MTHFR
MMS3_k127_387483_3	1411123.JQNH01000001_gene2033	8.411e-42	166.0	COG0500@1|root,COG2226@2|Bacteria,1REVA@1224|Proteobacteria,2U929@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
MMS3_k127_387483_2	339860.Msp_1186	2.285e-46	175.0	COG1387@1|root,arCOG00304@2157|Archaea,2XVZY@28890|Euryarchaeota,23NXR@183925|Methanobacteria	183925|Methanobacteria	E	DNA polymerase alpha chain like domain	-	-	-	ko:K04477	-	-	-	-	ko00000	-	-	-	PHP
MMS3_k127_387483_10	673862.BABL1_1004	2.257e-06	61.0	COG3209@1|root,COG3209@2|Bacteria,1QW4H@1224|Proteobacteria,42ZEZ@68525|delta/epsilon subdivisions,2WT5G@28221|Deltaproteobacteria	1224|Proteobacteria	M	Immunoglobulin-like repeats containing protein domain	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Autotransporter,Big_3_5,DUF4347,He_PIG,RHS_repeat
MMS3_k127_3877393_1	273116.14324266	4.822e-131	436.0	COG1156@1|root,arCOG00865@2157|Archaea,2XSYQ@28890|Euryarchaeota,241K0@183967|Thermoplasmata	183967|Thermoplasmata	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit	atpB	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
MMS3_k127_3877393_0	1230342.CTM_21718	1.541e-228	721.0	COG1155@1|root,COG1155@2|Bacteria,1TPGS@1239|Firmicutes,24882@186801|Clostridia,36DW7@31979|Clostridiaceae	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit	atpA	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
MMS3_k127_3877393_11	263820.PTO0491	2.698e-10	65.0	COG1436@1|root,arCOG04102@2157|Archaea,2Y5Y7@28890|Euryarchaeota,242ET@183967|Thermoplasmata	183967|Thermoplasmata	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpF	-	-	ko:K02122	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_F
MMS3_k127_3877393_12	177437.HRM2_26720	1.613e-08	60.0	COG4231@1|root,COG4231@2|Bacteria,1N6WI@1224|Proteobacteria,42V3I@68525|delta/epsilon subdivisions,2WRKA@28221|Deltaproteobacteria,2MKZT@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
MMS3_k127_3877393_3	1459636.NTE_00871	2.824e-63	226.0	COG1801@1|root,arCOG04291@2157|Archaea,41T6J@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
MMS3_k127_3877393_6	304371.MCP_2179	1.797e-30	129.0	COG0500@1|root,arCOG02702@2157|Archaea,2XWS9@28890|Euryarchaeota,2NAVE@224756|Methanomicrobia	224756|Methanomicrobia	Q	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
MMS3_k127_3877393_14	1114856.C496_05937	0.0005457	52.0	arCOG08101@1|root,arCOG08101@2157|Archaea,2XX0M@28890|Euryarchaeota,23VDA@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_3877393_2	1459636.NTE_00007	5.73e-113	393.0	COG0417@1|root,arCOG00329@2157|Archaea	2157|Archaea	L	DNA polymerase elongation subunit (Family B)	polB2	-	2.7.7.7	ko:K02319	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_pol_B
MMS3_k127_3877393_4	867845.KI911784_gene2774	1.851e-43	180.0	COG1413@1|root,COG1674@1|root,COG5635@1|root,COG1413@2|Bacteria,COG1674@2|Bacteria,COG5635@2|Bacteria,2G8R0@200795|Chloroflexi,3766B@32061|Chloroflexia	32061|Chloroflexia	CDT	Armadillo/beta-catenin-like repeats	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
MMS3_k127_3877393_13	28444.JODQ01000002_gene4367	0.0001521	55.0	COG0454@1|root,COG0456@2|Bacteria,2IM9R@201174|Actinobacteria,4EJP4@85012|Streptosporangiales	201174|Actinobacteria	K	This enzyme acetylates the N-terminal alanine of ribosomal protein S18	rimI	GO:0003674,GO:0003824,GO:0004596,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0031365,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
MMS3_k127_3877393_10	1121468.AUBR01000014_gene2195	5.752e-12	77.0	COG2309@1|root,COG2309@2|Bacteria,1UMYG@1239|Firmicutes,24BYI@186801|Clostridia,42GN7@68295|Thermoanaerobacterales	186801|Clostridia	E	Thermophilic metalloprotease (M29)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M29
MMS3_k127_3877393_7	1437824.BN940_13236	7.614e-30	131.0	COG2094@1|root,COG2094@2|Bacteria,1RE0A@1224|Proteobacteria,2W3S9@28216|Betaproteobacteria,3T93X@506|Alcaligenaceae	28216|Betaproteobacteria	L	Methylpurine-DNA glycosylase (MPG)	-	-	3.2.2.21	ko:K03652	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Pur_DNA_glyco
MMS3_k127_3877393_9	348780.NP_4310A	7.114e-13	70.0	COG2126@1|root,arCOG04126@2157|Archaea,2XZUV@28890|Euryarchaeota,23XE9@183963|Halobacteria	183963|Halobacteria	J	binds to the 23S rRNA	rpl37e	-	-	ko:K02922	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L37e
MMS3_k127_3877393_8	868131.MSWAN_0506	6.258e-18	85.0	COG1958@1|root,arCOG00998@2157|Archaea,2XZTF@28890|Euryarchaeota,23P7B@183925|Methanobacteria	183925|Methanobacteria	K	Belongs to the snRNP Sm proteins family	-	-	-	ko:K04796	-	-	-	-	ko00000	-	-	-	LSM
MMS3_k127_3877393_5	1120973.AQXL01000119_gene527	2.264e-40	162.0	COG0294@1|root,COG0294@2|Bacteria,1TPKT@1239|Firmicutes,4H9SY@91061|Bacilli,277X0@186823|Alicyclobacillaceae	91061|Bacilli	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	folP	GO:0003674,GO:0003824,GO:0004156,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
MMS3_k127_3921998_0	439481.Aboo_1381	1.475e-193	653.0	COG1196@1|root,arCOG00371@2157|Archaea,2XSVK@28890|Euryarchaeota,3F2HY@33867|unclassified Euryarchaeota	28890|Euryarchaeota	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
MMS3_k127_3921998_3	673860.AciM339_1194	7.68e-39	158.0	COG1354@1|root,arCOG02610@2157|Archaea,2XZHK@28890|Euryarchaeota,3F2QG@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	chromosome segregation and condensation protein ScpA	-	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
MMS3_k127_3921998_4	439481.Aboo_1099	5.022e-26	123.0	COG1386@1|root,arCOG02613@2157|Archaea,2XZ7Q@28890|Euryarchaeota,3F2S6@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	TIGRFAM segregation and condensation protein B	scpB	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
MMS3_k127_3921998_6	1500894.JQNN01000001_gene907	1.004e-20	108.0	COG4934@1|root,COG4934@2|Bacteria,1R55X@1224|Proteobacteria,2VR5H@28216|Betaproteobacteria,475XI@75682|Oxalobacteraceae	28216|Betaproteobacteria	O	Pro-kumamolisin, activation domain	kscp	-	-	ko:K08677	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_S8,Pro-kuma_activ
MMS3_k127_3921998_5	579137.Metvu_0286	1.388e-21	106.0	COG0537@1|root,arCOG00419@2157|Archaea,2XXWC@28890|Euryarchaeota,23QZT@183939|Methanococci	183939|Methanococci	F	PFAM Histidine triad (HIT) protein	-	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
MMS3_k127_3921998_2	673860.AciM339_1253	4.981e-54	219.0	COG1355@1|root,arCOG01728@2157|Archaea,2XVYU@28890|Euryarchaeota,3F2NT@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Belongs to the MEMO1 family	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0032886,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0065007	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
MMS3_k127_3921998_1	1121957.ATVL01000007_gene2350	7.952e-73	250.0	COG0717@1|root,COG0717@2|Bacteria,4NFRS@976|Bacteroidetes,47M70@768503|Cytophagia	976|Bacteroidetes	F	Deoxycytidine triphosphate deaminase	dcd	-	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	-
MMS3_k127_3926929_1	247490.KSU1_D0178	5.403e-34	136.0	COG2410@1|root,COG2410@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF429)	-	-	-	ko:K09147	-	-	-	-	ko00000	-	-	-	DUF429
MMS3_k127_3926929_3	456442.Mboo_1440	6.866e-06	58.0	COG3291@1|root,arCOG02527@1|root,arCOG02510@2157|Archaea,arCOG02527@2157|Archaea	2157|Archaea	O	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBM_6,NosD,PKD
MMS3_k127_3926929_0	1047013.AQSP01000122_gene2224	5.093e-41	173.0	COG3291@1|root,COG5434@1|root,COG3291@2|Bacteria,COG5434@2|Bacteria,2NQ6Y@2323|unclassified Bacteria	2|Bacteria	M	PKD domain	-	-	3.2.1.157,3.2.1.91	ko:K19668,ko:K20850	ko00500,ko01100,ko02020,map00500,map01100,map02020	-	R02886,R11308	RC00799	ko00000,ko00001,ko01000	-	GH6,GH82	-	Beta_helix,CHU_C,Cadherin-like,FlgD_ig,PKD,Pectate_lyase_3
MMS3_k127_3926929_2	59894.ENSFALP00000014370	4.169e-07	63.0	2AB8N@1|root,2RYNR@2759|Eukaryota,39TQ5@33154|Opisthokonta,3BN5V@33208|Metazoa,3D0PR@33213|Bilateria,485YH@7711|Chordata,4929C@7742|Vertebrata,4GK84@8782|Aves	33208|Metazoa	S	Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle	ELN	GO:0001101,GO:0001568,GO:0001666,GO:0001944,GO:0001974,GO:0003007,GO:0003008,GO:0003013,GO:0003151,GO:0003170,GO:0003176,GO:0003179,GO:0003180,GO:0003674,GO:0005198,GO:0005201,GO:0005488,GO:0005575,GO:0005576,GO:0005615,GO:0006950,GO:0006996,GO:0007010,GO:0007015,GO:0007154,GO:0007275,GO:0007507,GO:0007517,GO:0007519,GO:0007568,GO:0007584,GO:0007585,GO:0008015,GO:0008064,GO:0008150,GO:0008283,GO:0009410,GO:0009605,GO:0009628,GO:0009653,GO:0009719,GO:0009725,GO:0009743,GO:0009887,GO:0009888,GO:0009987,GO:0009991,GO:0010033,GO:0010035,GO:0010038,GO:0014070,GO:0014706,GO:0016043,GO:0022607,GO:0030023,GO:0030029,GO:0030036,GO:0030038,GO:0030198,GO:0030832,GO:0030833,GO:0031012,GO:0031032,GO:0031667,GO:0031668,GO:0031669,GO:0031670,GO:0031960,GO:0032271,GO:0032501,GO:0032502,GO:0032526,GO:0032535,GO:0032870,GO:0032956,GO:0032970,GO:0033043,GO:0033273,GO:0033554,GO:0033591,GO:0033993,GO:0034284,GO:0035690,GO:0035904,GO:0036293,GO:0036294,GO:0036296,GO:0042221,GO:0042493,GO:0043062,GO:0043149,GO:0043254,GO:0044085,GO:0044087,GO:0044344,GO:0044420,GO:0044421,GO:0046688,GO:0048251,GO:0048513,GO:0048545,GO:0048731,GO:0048771,GO:0048856,GO:0050789,GO:0050794,GO:0050840,GO:0050896,GO:0051017,GO:0051128,GO:0051384,GO:0051493,GO:0051716,GO:0055093,GO:0060537,GO:0060538,GO:0060840,GO:0061061,GO:0061572,GO:0065007,GO:0065008,GO:0070482,GO:0070848,GO:0070887,GO:0071229,GO:0071241,GO:0071248,GO:0071280,GO:0071295,GO:0071298,GO:0071300,GO:0071310,GO:0071322,GO:0071326,GO:0071363,GO:0071383,GO:0071384,GO:0071385,GO:0071396,GO:0071407,GO:0071453,GO:0071456,GO:0071466,GO:0071495,GO:0071496,GO:0071548,GO:0071549,GO:0071559,GO:0071560,GO:0071774,GO:0071840,GO:0071953,GO:0072358,GO:0072359,GO:0085029,GO:0090066,GO:0097327,GO:0097435,GO:0097493,GO:0110053,GO:1901654,GO:1901655,GO:1901700,GO:1901701,GO:1902903,GO:1905314	-	ko:K14211	ko04974,map04974	-	-	-	ko00000,ko00001	-	-	-	-
MMS3_k127_3954671_27	1380386.JIAW01000018_gene2930	0.0005777	48.0	COG1545@1|root,COG1545@2|Bacteria,2GMU9@201174|Actinobacteria,2360B@1762|Mycobacteriaceae	201174|Actinobacteria	S	Nucleic-acid-binding protein containing a Zn-ribbon	-	-	-	-	-	-	-	-	-	-	-	-	OB_aCoA_assoc
MMS3_k127_3954671_6	406552.NJ7G_2315	8.799e-114	394.0	COG0183@1|root,arCOG01278@2157|Archaea,2XT38@28890|Euryarchaeota,23SC3@183963|Halobacteria	183963|Halobacteria	I	COG0183 Acetyl-CoA acetyltransferase	acaB2	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
MMS3_k127_3954671_12	498848.TaqDRAFT_4674	2.794e-44	182.0	COG0163@1|root,COG0163@2|Bacteria,1WIWQ@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	H	Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN	ubiX	GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0044237,GO:0044249,GO:0051186,GO:0051188	2.5.1.129	ko:K03186	ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220	M00117	R01238,R02952,R03367,R04985,R04986,R11225	RC00391,RC00814,RC03392	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavoprotein
MMS3_k127_3954671_11	1236689.MMALV_00390	1.018e-52	198.0	COG0518@1|root,arCOG00087@2157|Archaea,2XT3G@28890|Euryarchaeota,3F2M8@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	Catalyzes the synthesis of GMP from XMP	guaAA	GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase
MMS3_k127_3954671_17	1054217.TALC_00198	5.873e-17	94.0	arCOG05338@1|root,arCOG05338@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_3954671_19	176299.Atu4047	8.623e-07	56.0	COG0784@1|root,COG2461@1|root,COG4191@1|root,COG0784@2|Bacteria,COG2461@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria,4B880@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_4,PAS_9,Response_reg
MMS3_k127_3954671_13	673860.AciM339_0455	1.507e-33	147.0	COG1798@1|root,arCOG04161@2157|Archaea,2XV63@28890|Euryarchaeota,3F2J0@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF- 2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis	dphB	GO:0003674,GO:0003824,GO:0004164,GO:0006417,GO:0006448,GO:0006464,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0009056,GO:0009058,GO:0009109,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0010608,GO:0016740,GO:0016741,GO:0017144,GO:0017182,GO:0017183,GO:0018193,GO:0018202,GO:0019222,GO:0019538,GO:0031323,GO:0031326,GO:0032259,GO:0032268,GO:0034248,GO:0036211,GO:0042737,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044267,GO:0044273,GO:0046500,GO:0050789,GO:0050794,GO:0050843,GO:0051171,GO:0051186,GO:0051187,GO:0051246,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:1900247,GO:1901564,GO:1901575,GO:2000112,GO:2000765	2.1.1.98	ko:K20215	-	-	R04481,R08468,R08469,R10306	RC00003,RC00190,RC01155,RC02136,RC02308	ko00000,ko01000	-	-	iAF692.Mbar_A2900	TP_methylase
MMS3_k127_3954671_24	1230460.C495_04807	2.759e-05	57.0	COG0589@1|root,arCOG00449@2157|Archaea,2XU1E@28890|Euryarchaeota,23TYX@183963|Halobacteria	183963|Halobacteria	T	COG0589 Universal stress protein UspA and related nucleotide-binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Usp
MMS3_k127_3954671_15	1536770.R50345_02635	1.577e-25	121.0	COG2156@1|root,COG2156@2|Bacteria,1V4GE@1239|Firmicutes,4HHHD@91061|Bacilli,26UQ3@186822|Paenibacillaceae	91061|Bacilli	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex	kdpC	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044425,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132	3.6.3.12	ko:K01548	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	-	KdpC
MMS3_k127_3954671_0	98439.AJLL01000090_gene141	8.855e-206	661.0	COG2216@1|root,COG2216@2|Bacteria,1G4PH@1117|Cyanobacteria,1JHM9@1189|Stigonemataceae	1117|Cyanobacteria	P	haloacid dehalogenase-like hydrolase	kdpB	-	3.6.3.12	ko:K01547	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	-	E1-E2_ATPase,Hydrolase
MMS3_k127_3954671_3	755731.Clo1100_3924	3.901e-130	435.0	COG2060@1|root,COG2060@2|Bacteria,1TPDF@1239|Firmicutes,24868@186801|Clostridia,36DPN@31979|Clostridiaceae	186801|Clostridia	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane	kdpA	-	3.6.3.12	ko:K01546	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	-	KdpA
MMS3_k127_3954671_9	572546.Arcpr_0223	1.739e-88	328.0	COG1111@1|root,arCOG00872@2157|Archaea,2XTBV@28890|Euryarchaeota,245TM@183980|Archaeoglobi	183980|Archaeoglobi	L	DEAD DEAH box helicase domain protein	-	-	-	ko:K10896	ko03460,map03460	M00413	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	DEAD,ERCC4,HHH_2,HHH_5,Helicase_C
MMS3_k127_3954671_4	1094980.Mpsy_2683	4.882e-126	422.0	COG0172@1|root,arCOG00403@2157|Archaea,2XUK2@28890|Euryarchaeota,2N9B1@224756|Methanomicrobia	224756|Methanomicrobia	J	able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	-	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF692.Mbar_A2126	-
MMS3_k127_3954671_1	867903.ThesuDRAFT_00160	7.635e-168	548.0	COG1012@1|root,COG1012@2|Bacteria,1TP4S@1239|Firmicutes,247W7@186801|Clostridia	186801|Clostridia	C	Belongs to the aldehyde dehydrogenase family	-	-	-	ko:K22187	ko00040,map00040	-	R11768	RC00080	ko00000,ko00001,ko01000	-	-	-	Aldedh
MMS3_k127_3954671_7	439481.Aboo_0001	1.403e-100	353.0	COG1474@1|root,arCOG00467@2157|Archaea,2XU73@28890|Euryarchaeota,3F2IJ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Involved in regulation of DNA replication	cdc6	-	-	ko:K10725	-	-	-	-	ko00000,ko03032	-	-	-	AAA,AAA_16,AAA_22,Cdc6_C
MMS3_k127_3954671_10	235985.BBPN01000048_gene8222	3.48e-87	319.0	COG3405@1|root,COG4409@1|root,COG3405@2|Bacteria,COG4409@2|Bacteria,2ID1A@201174|Actinobacteria,2NGZY@228398|Streptacidiphilus	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase 8 (cellulase D) family	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_3954671_16	1047013.AQSP01000122_gene2224	1.299e-19	106.0	COG3291@1|root,COG5434@1|root,COG3291@2|Bacteria,COG5434@2|Bacteria,2NQ6Y@2323|unclassified Bacteria	2|Bacteria	M	PKD domain	-	-	3.2.1.157,3.2.1.91	ko:K19668,ko:K20850	ko00500,ko01100,ko02020,map00500,map01100,map02020	-	R02886,R11308	RC00799	ko00000,ko00001,ko01000	-	GH6,GH82	-	Beta_helix,CHU_C,Cadherin-like,FlgD_ig,PKD,Pectate_lyase_3
MMS3_k127_3954671_18	1385510.N781_09540	1.217e-08	69.0	COG2373@1|root,COG4932@1|root,COG2373@2|Bacteria,COG4932@2|Bacteria,1UXD9@1239|Firmicutes,4I2J1@91061|Bacilli,2YBSI@289201|Pontibacillus	91061|Bacilli	M	SdrD B-like domain	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_3954671_26	1236976.JCM16418_3603	0.0004242	54.0	COG4409@1|root,COG4409@2|Bacteria,1VTIQ@1239|Firmicutes,4HUHA@91061|Bacilli,26TV7@186822|Paenibacillaceae	91061|Bacilli	G	exo-alpha-(2->6)-sialidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_3954671_22	468059.AUHA01000002_gene896	7.191e-06	60.0	COG3420@1|root,COG5184@1|root,COG5492@1|root,COG3420@2|Bacteria,COG5184@2|Bacteria,COG5492@2|Bacteria,4NMRB@976|Bacteroidetes,1ITFX@117747|Sphingobacteriia	976|Bacteroidetes	P	Protein of unknown function (DUF3494)	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,DUF3494,Flg_new
MMS3_k127_3954671_2	273057.SSO2420	1.239e-138	484.0	COG0464@1|root,arCOG01308@2157|Archaea,2XRPM@28889|Crenarchaeota	28889|Crenarchaeota	O	ATPase family	-	-	-	-	-	-	-	-	-	-	-	-	AAA,Vps4_C
MMS3_k127_3954671_20	1144275.COCOR_01280	1.83e-06	63.0	COG4932@1|root,COG5184@1|root,COG4932@2|Bacteria,COG5184@2|Bacteria,1R5S8@1224|Proteobacteria	1224|Proteobacteria	M	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
MMS3_k127_3954671_21	1396141.BATP01000022_gene342	2.303e-06	62.0	COG1262@1|root,COG1345@1|root,COG1409@1|root,COG1262@2|Bacteria,COG1345@2|Bacteria,COG1409@2|Bacteria,46WEI@74201|Verrucomicrobia,2IVF7@203494|Verrucomicrobiae	2|Bacteria	N	Sulfatase-modifying factor enzyme 1	-	-	3.1.4.53	ko:K02396,ko:K03651	ko00230,ko02025,ko02040,map00230,map02025,map02040	-	R00191	RC00296	ko00000,ko00001,ko01000,ko02035	-	-	-	FGE-sulfatase,Flg_bbr_C,Metallophos,TMP_2,VCBS
MMS3_k127_3954671_23	1198449.ACAM_1183	2.075e-05	59.0	arCOG00372@1|root,arCOG00372@2157|Archaea	2157|Archaea	P	cobalamin transport	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_3954671_25	479433.Caci_6979	3.53e-05	58.0	COG4409@1|root,COG4409@2|Bacteria,2GN94@201174|Actinobacteria	201174|Actinobacteria	G	M6 family metalloprotease domain protein	-	-	-	-	-	-	-	-	-	-	-	-	BNR_2
MMS3_k127_3954671_14	1220534.B655_1466	8.409e-28	123.0	COG1608@1|root,arCOG00860@2157|Archaea,2XSUI@28890|Euryarchaeota,23NXS@183925|Methanobacteria	183925|Methanobacteria	I	Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids	-	-	2.7.4.26	ko:K06981	ko00900,ko01110,ko01130,map00900,map01110,map01130	-	R10093	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
MMS3_k127_3954671_8	1236689.MMALV_14500	1.8e-93	319.0	COG1304@1|root,arCOG00613@2157|Archaea,2XT6H@28890|Euryarchaeota,3F2I8@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)	fni	-	5.3.3.2	ko:K01823	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00095,M00096,M00364,M00365,M00366,M00367	R01123	RC00455	ko00000,ko00001,ko00002,ko01000	-	-	-	FMN_dh
MMS3_k127_3954671_5	673860.AciM339_1396	3.73e-119	413.0	COG1243@1|root,arCOG01361@2157|Archaea,2XT9Z@28890|Euryarchaeota,3F2HC@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	Radical_SAM C-terminal domain	elp3	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.3.1.48	ko:K07739	-	-	-	-	ko00000,ko01000,ko03016,ko03036	-	-	-	Acetyltransf_1,Radical_SAM,Radical_SAM_C
MMS3_k127_4026348_0	439481.Aboo_0417	1.152e-55	198.0	COG0020@1|root,arCOG01532@2157|Archaea,2XSW1@28890|Euryarchaeota,3F2F2@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids	uppS	GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617	2.5.1.89	ko:K15888	ko00900,map00900	-	R09730	RC00279,RC02839	ko00000,ko00001,ko01000	-	-	-	Prenyltransf
MMS3_k127_4026348_2	215803.DB30_5402	5.811e-10	73.0	COG3055@1|root,COG3055@2|Bacteria,1QA4H@1224|Proteobacteria,434UC@68525|delta/epsilon subdivisions,2WZ59@28221|Deltaproteobacteria,2Z1D3@29|Myxococcales	28221|Deltaproteobacteria	S	Galactose oxidase, central domain	-	-	-	-	-	-	-	-	-	-	-	-	Kelch_6
MMS3_k127_4026348_3	1463825.JNXC01000007_gene1042	3.957e-06	61.0	COG2133@1|root,COG3291@1|root,COG3506@1|root,COG3828@1|root,COG2133@2|Bacteria,COG3291@2|Bacteria,COG3506@2|Bacteria,COG3828@2|Bacteria,2GJFY@201174|Actinobacteria,4E915@85010|Pseudonocardiales	201174|Actinobacteria	G	Carbohydrate binding module (family 6)	-	-	-	-	-	-	-	-	-	-	-	-	CBM_6,DUF1349,GSDH,PKD,RicinB_lectin_2,ThuA
MMS3_k127_4026348_1	105422.BBPM01000001_gene4678	1.342e-12	82.0	COG3291@1|root,COG3291@2|Bacteria,2HHTF@201174|Actinobacteria,2NHQJ@228398|Streptacidiphilus	201174|Actinobacteria	S	PKD domain	-	-	-	-	-	-	-	-	-	-	-	-	PKD,Phosphoesterase,fn3
MMS3_k127_406384_0	673860.AciM339_1206	9.675e-122	402.0	COG1503@1|root,arCOG01742@2157|Archaea,2XSV5@28890|Euryarchaeota,3F2IF@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA	prf1	-	-	ko:K03265	ko03015,map03015	-	-	-	ko00000,ko00001,ko03012,ko03019	-	-	-	eRF1_1,eRF1_2,eRF1_3
MMS3_k127_406384_11	679897.HMU09770	5.321e-24	119.0	COG3118@1|root,COG3118@2|Bacteria,1MZBB@1224|Proteobacteria,42TPU@68525|delta/epsilon subdivisions,2YPES@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	O	Belongs to the thioredoxin family	trx	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	iIT341.HP0824	Thioredoxin
MMS3_k127_406384_14	390989.JOEG01000014_gene2987	2.292e-06	58.0	COG4122@1|root,COG4122@2|Bacteria,2GP7A@201174|Actinobacteria,4DG6V@85008|Micromonosporales	201174|Actinobacteria	S	O-methyltransferase	-	-	-	ko:K21189	ko01059,map01059	M00828	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_3
MMS3_k127_406384_9	330214.NIDE2773	1.472e-30	133.0	COG0521@1|root,COG0521@2|Bacteria	2|Bacteria	H	Mo-molybdopterin cofactor metabolic process	moaB	-	2.7.7.75	ko:K03638	ko00790,ko01100,map00790,map01100	-	R09726	RC00002	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth
MMS3_k127_406384_7	593117.TGAM_1031	4.485e-33	145.0	COG0315@1|root,arCOG01530@2157|Archaea,2XWHQ@28890|Euryarchaeota,243UY@183968|Thermococci	183968|Thermococci	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
MMS3_k127_406384_4	673860.AciM339_0861	2.508e-102	342.0	COG0470@1|root,arCOG00469@2157|Archaea,2XTC8@28890|Euryarchaeota,3F2I9@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA	rfcS	GO:0005575,GO:0005622,GO:0005623,GO:0005657,GO:0005663,GO:0005694,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360,GO:1901576	-	ko:K04801	ko03030,map03030	-	-	-	ko00000,ko00001,ko03032	-	-	-	AAA,DNA_pol3_delta2,HTH_3,Intein_splicing,LAGLIDADG_3,Rad17,Rep_fac_C,RuvB_N
MMS3_k127_406384_8	641491.DND132_2537	7.661e-33	143.0	COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,42MNA@68525|delta/epsilon subdivisions,2WK7Z@28221|Deltaproteobacteria,2M961@213115|Desulfovibrionales	28221|Deltaproteobacteria	OU	signal peptide peptidase SppA, 36K type	sppA	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
MMS3_k127_406384_15	273075.Ta1302a	1.147e-05	49.0	COG4023@1|root,arCOG02957@2157|Archaea,2Y1AH@28890|Euryarchaeota,242FI@183967|Thermoplasmata	183967|Thermoplasmata	U	but it may be involved in stabilization of the trimeric complex	secG	-	-	-	-	-	-	-	-	-	-	-	Sec61_beta
MMS3_k127_406384_2	673860.AciM339_0566	5.257e-113	374.0	COG0731@1|root,arCOG04174@2157|Archaea,2XSTF@28890|Euryarchaeota,3F2ET@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe)	taw1	-	4.1.3.44	ko:K15449	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,Wyosine_form
MMS3_k127_406384_10	1283300.ATXB01000002_gene3086	6.697e-28	115.0	COG0607@1|root,COG0607@2|Bacteria,1MZPW@1224|Proteobacteria,1THRV@1236|Gammaproteobacteria,1XFHD@135618|Methylococcales	135618|Methylococcales	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
MMS3_k127_406384_6	1459636.NTE_00973	5.387e-61	226.0	arCOG04555@1|root,arCOG04555@2157|Archaea	2157|Archaea	S	Integral membrane protein CcmA involved in cell shape determination	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
MMS3_k127_406384_5	215803.DB30_7410	7.301e-74	258.0	COG1573@1|root,COG1573@2|Bacteria,1MW91@1224|Proteobacteria,42SMW@68525|delta/epsilon subdivisions,2WPP1@28221|Deltaproteobacteria,2YUYP@29|Myxococcales	28221|Deltaproteobacteria	L	uracil-DNA glycosylase	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
MMS3_k127_406384_1	673860.AciM339_0479	3.644e-115	394.0	COG0343@1|root,COG1370@1|root,arCOG00989@2157|Archaea,arCOG00991@2157|Archaea,2XTFH@28890|Euryarchaeota,3F2F8@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Exchanges the guanine residue with 7-cyano-7- deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D- loop) of archaeal tRNAs	tgtA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046116,GO:0046483,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.2.48	ko:K18779	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PUA,TGT,TGT_C1,TGT_C2
MMS3_k127_406384_13	673860.AciM339_0628	2.013e-14	76.0	arCOG05238@1|root,arCOG05238@2157|Archaea,2Y0YG@28890|Euryarchaeota,3F3EA@33867|unclassified Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_406384_3	1236689.MMALV_15600	4.64e-112	371.0	COG0533@1|root,arCOG01183@2157|Archaea,2Y86G@28890|Euryarchaeota	28890|Euryarchaeota	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity	kae1	GO:0000049,GO:0000408,GO:0002949,GO:0003674,GO:0003676,GO:0003723,GO:0003727,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
MMS3_k127_4107161_1	439481.Aboo_0743	1.148e-151	488.0	COG1697@1|root,arCOG04143@2157|Archaea,2XTNQ@28890|Euryarchaeota,3F2HT@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Relaxes both positive and negative superturns and exhibits a strong decatenase activity	top6A	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003918,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0016889,GO:0016894,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0061505,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363	5.99.1.3	ko:K03166	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	TP6A_N
MMS3_k127_4107161_0	673860.AciM339_0322	7.958e-197	634.0	COG1389@1|root,arCOG01165@2157|Archaea,2XTZQ@28890|Euryarchaeota,3F2EU@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Relaxes both positive and negative superturns and exhibits a strong decatenase activity	top6B	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	5.99.1.3	ko:K03167	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	HATPase_c,Topo-VIb_trans
MMS3_k127_4111106_5	273075.Ta1426m	2.173e-11	66.0	COG2443@1|root,arCOG02204@2157|Archaea,2Y6IT@28890|Euryarchaeota,241W4@183967|Thermoplasmata	183967|Thermoplasmata	U	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation	-	-	-	ko:K07342	ko03060,ko04141,ko04145,ko05110,map03060,map04141,map04145,map05110	M00401	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.7,3.A.5.8,3.A.5.9	-	-	-
MMS3_k127_4111106_0	1236689.MMALV_00440	1.467e-43	171.0	COG0250@1|root,arCOG01920@2157|Archaea,2XWGQ@28890|Euryarchaeota,3F2RK@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	Transcription elongation factor Spt5	spt5	GO:0003674,GO:0003676,GO:0003677,GO:0003723,GO:0003729,GO:0005488,GO:0006139,GO:0006351,GO:0006354,GO:0006355,GO:0006357,GO:0006366,GO:0006368,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016071,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:2000112,GO:2001141	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,Spt5-NGN
MMS3_k127_4111106_1	673860.AciM339_0145	8.654e-40	154.0	COG0080@1|root,arCOG04372@2157|Archaea,2XTJN@28890|Euryarchaeota,3F2N7@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rpl11	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
MMS3_k127_4111106_3	273075.Ta0916	4.861e-14	81.0	arCOG05390@1|root,arCOG05390@2157|Archaea,2Y4YT@28890|Euryarchaeota,242E1@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_4111106_4	1509405.GV67_03875	1.519e-13	77.0	COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,2UFRX@28211|Alphaproteobacteria,4BEM4@82115|Rhizobiaceae	28211|Alphaproteobacteria	O	Belongs to the small heat shock protein (HSP20) family	hspC2	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
MMS3_k127_4111106_2	410358.Mlab_0638	8.819e-32	133.0	COG0561@1|root,arCOG01213@2157|Archaea,2XX94@28890|Euryarchaeota,2N9JY@224756|Methanomicrobia	224756|Methanomicrobia	G	Catalyzes the dephosphorylation of 2-phosphoglycolate	-	-	3.1.3.18	ko:K22223	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	Hydrolase_3
MMS3_k127_4136744_19	1054217.TALC_01291	1.547e-16	89.0	COG0239@1|root,arCOG04701@2157|Archaea	2157|Archaea	U	Important for reducing fluoride concentration in the cell, thus reducing its toxicity	crcB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425	-	ko:K06199	-	-	-	-	ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3	-	-	CRCB
MMS3_k127_4136744_15	670487.Ocepr_1535	9.764e-28	117.0	COG1993@1|root,COG1993@2|Bacteria,1WKB2@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Uncharacterized ACR, COG1993	-	-	-	ko:K09137	-	-	-	-	ko00000	-	-	-	DUF190
MMS3_k127_4136744_24	416348.Hlac_3545	1.876e-08	67.0	COG0517@1|root,arCOG00601@2157|Archaea,2XVRW@28890|Euryarchaeota,23S35@183963|Halobacteria	183963|Halobacteria	S	COG0517 FOG CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
MMS3_k127_4136744_0	439481.Aboo_1394	9.895e-173	558.0	COG0466@1|root,arCOG02162@2157|Archaea,2XVMC@28890|Euryarchaeota,3F2HJ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	O	AAA domain	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA_32,Mg_chelatase,Sigma54_activat
MMS3_k127_4136744_2	673860.AciM339_1561	5.815e-125	414.0	COG0358@1|root,arCOG04281@2157|Archaea,2XTHB@28890|Euryarchaeota,3F2FZ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Toprim domain	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	Toprim_4
MMS3_k127_4136744_14	673860.AciM339_0490	1.34e-30	131.0	arCOG13525@1|root,arCOG13525@2157|Archaea,2Y72N@28890|Euryarchaeota,3F3A7@33867|unclassified Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_4136744_7	304371.MCP_2998	8.893e-88	309.0	COG1311@1|root,arCOG04455@2157|Archaea,2XSUG@28890|Euryarchaeota,2N96N@224756|Methanomicrobia	224756|Methanomicrobia	L	Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase	polB	-	2.7.7.7	ko:K02323	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	M00264	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	DNA_pol_E_B,Metallophos,tRNA_anti-codon
MMS3_k127_4136744_21	410359.Pcal_1667	3.477e-13	83.0	COG1324@1|root,arCOG04231@2157|Archaea,2XR6Y@28889|Crenarchaeota	28889|Crenarchaeota	P	PFAM CutA1 divalent ion tolerance protein	-	-	-	ko:K03926	-	-	-	-	ko00000	-	-	-	CutA1
MMS3_k127_4136744_4	429009.Adeg_1616	6.109e-107	359.0	COG0126@1|root,COG0126@2|Bacteria,1TP3H@1239|Firmicutes,248VS@186801|Clostridia,42F8F@68295|Thermoanaerobacterales	186801|Clostridia	F	Belongs to the phosphoglycerate kinase family	pgk	-	2.7.2.3,5.3.1.1	ko:K00927,ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01015,R01512	RC00002,RC00043,RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
MMS3_k127_4136744_12	1125863.JAFN01000001_gene2588	7.598e-36	150.0	COG1893@1|root,COG1893@2|Bacteria,1P0AW@1224|Proteobacteria,42QZK@68525|delta/epsilon subdivisions,2WPP6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
MMS3_k127_4136744_5	861299.J421_3301	1.621e-99	334.0	COG0039@1|root,COG0039@2|Bacteria,1ZSV3@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	-	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
MMS3_k127_4136744_3	1236689.MMALV_01670	1.851e-108	378.0	COG1199@1|root,arCOG00770@2157|Archaea,2XTH2@28890|Euryarchaeota,3F2IN@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	HELICc2	rad3b	-	3.6.4.12	ko:K03722,ko:K10844	ko03022,ko03420,map03022,map03420	M00290	-	-	ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	DEAD_2,HBB,Helicase_C_2,ResIII
MMS3_k127_4136744_6	326427.Cagg_0788	3.621e-92	316.0	COG2605@1|root,COG2605@2|Bacteria,2G5TF@200795|Chloroflexi,37752@32061|Chloroflexia	32061|Chloroflexia	S	PFAM GHMP kinase	-	-	2.7.1.168	ko:K07031	ko00540,map00540	-	R09770	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
MMS3_k127_4136744_11	596151.DesfrDRAFT_2590	1.141e-42	164.0	COG0279@1|root,COG2605@1|root,COG0279@2|Bacteria,COG2605@2|Bacteria,1QWU7@1224|Proteobacteria,42QI3@68525|delta/epsilon subdivisions,2X8DE@28221|Deltaproteobacteria,2MGSC@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	GHMP kinases C terminal	-	-	2.7.1.168	ko:K07031	ko00540,map00540	-	R09770	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N,SIS_2
MMS3_k127_4136744_9	1457250.BBMO01000001_gene1113	1.655e-58	222.0	COG1475@1|root,arCOG00622@2157|Archaea,2XTYJ@28890|Euryarchaeota,23S7H@183963|Halobacteria	183963|Halobacteria	K	COG0517 FOG CBS domain	cbs10	-	-	-	-	-	-	-	-	-	-	-	CBS,ParBc
MMS3_k127_4136744_26	316274.Haur_0759	0.0004867	52.0	COG3794@1|root,COG4454@1|root,COG3794@2|Bacteria,COG4454@2|Bacteria,2GA6H@200795|Chloroflexi	200795|Chloroflexi	P	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cupredoxin_1
MMS3_k127_4136744_17	1200792.AKYF01000026_gene163	1.393e-22	116.0	COG4932@1|root,COG4932@2|Bacteria,1UJQY@1239|Firmicutes,4ITDJ@91061|Bacilli,270X3@186822|Paenibacillaceae	91061|Bacilli	M	CarboxypepD_reg-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
MMS3_k127_4136744_18	1111479.AXAR01000001_gene169	3.367e-21	99.0	COG1622@1|root,COG1622@2|Bacteria,1TRC3@1239|Firmicutes,4HADQ@91061|Bacilli	91061|Bacilli	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	-	-	-	-	-	-	-	-	-	-	-	-	COX2,COX2_TM,Cytochrom_C
MMS3_k127_4136744_23	397948.Cmaq_0447	1.094e-09	70.0	COG0704@1|root,arCOG00318@2157|Archaea,2XQIE@28889|Crenarchaeota	28889|Crenarchaeota	K	Phosphate uptake regulator, PhoU	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin,PhoU
MMS3_k127_4136744_20	1056495.Calag_1346	9.133e-14	72.0	COG1826@1|root,arCOG02694@2157|Archaea,2XSHK@28889|Crenarchaeota	28889|Crenarchaeota	U	mttA/Hcf106 family	-	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
MMS3_k127_4136744_10	1131266.ARWQ01000002_gene594	4.125e-43	168.0	COG0805@1|root,arCOG01919@2157|Archaea,41S69@651137|Thaumarchaeota	651137|Thaumarchaeota	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
MMS3_k127_4136744_13	397948.Cmaq_1911	1.023e-32	139.0	COG0723@1|root,arCOG01720@2157|Archaea,2XQYD@28889|Crenarchaeota	28889|Crenarchaeota	P	PFAM Rieske 2Fe-2S domain	soxL	-	-	-	-	-	-	-	-	-	-	-	Rieske
MMS3_k127_4136744_8	1056495.Calag_1350	9.485e-70	253.0	COG1290@1|root,arCOG01721@2157|Archaea,2XQAS@28889|Crenarchaeota	28889|Crenarchaeota	C	Cytochrome b	soxC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Cytochrom_B_C,Cytochrom_B_N_2
MMS3_k127_4136744_1	1283299.AUKG01000001_gene3228	3.181e-145	478.0	COG0843@1|root,COG0843@2|Bacteria,2GJHX@201174|Actinobacteria,4CP91@84995|Rubrobacteria	84995|Rubrobacteria	C	Cytochrome C and Quinol oxidase polypeptide I	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
MMS3_k127_4136744_22	479434.Sthe_3102	1.072e-12	77.0	COG1612@1|root,COG1612@2|Bacteria,2G75U@200795|Chloroflexi,27Y6J@189775|Thermomicrobia	189775|Thermomicrobia	O	Cytochrome oxidase assembly protein	-	-	-	ko:K02259	ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714	M00154	R07412	RC00769	ko00000,ko00001,ko00002,ko03029	3.D.4.4	-	-	COX15-CtaA
MMS3_k127_4136744_16	479434.Sthe_3168	1.709e-27	119.0	COG0109@1|root,COG1612@1|root,COG0109@2|Bacteria,COG1612@2|Bacteria,2G5UC@200795|Chloroflexi,27XHZ@189775|Thermomicrobia	189775|Thermomicrobia	O	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	ctaB	-	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	COX15-CtaA,UbiA
MMS3_k127_4158927_7	263820.PTO1344	4.852e-26	123.0	COG0477@1|root,arCOG00130@2157|Archaea,2Y8EG@28890|Euryarchaeota,2424M@183967|Thermoplasmata	183967|Thermoplasmata	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS3_k127_4158927_5	631454.N177_4188	1.403e-38	160.0	COG3191@1|root,COG3191@2|Bacteria,1MWDP@1224|Proteobacteria,2TRDC@28211|Alphaproteobacteria,1JN0U@119043|Rhodobiaceae	28211|Alphaproteobacteria	EQ	Peptidase family S58	dmpA	-	3.4.11.19	ko:K01266	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S58
MMS3_k127_4158927_8	351160.RCIX1743	1.473e-17	98.0	COG3620@1|root,arCOG00608@2157|Archaea,2XTDG@28890|Euryarchaeota,2N9J9@224756|Methanomicrobia	224756|Methanomicrobia	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	iAF692.Mbar_A2079	CBS,HTH_3
MMS3_k127_4158927_0	439481.Aboo_1133	1.619e-159	519.0	COG1032@1|root,arCOG01357@2157|Archaea,2XUCZ@28890|Euryarchaeota	28890|Euryarchaeota	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
MMS3_k127_4158927_6	1094980.Mpsy_0362	6.318e-27	119.0	COG1310@1|root,arCOG01139@2157|Archaea,2XWKU@28890|Euryarchaeota,2N9TM@224756|Methanomicrobia	224756|Methanomicrobia	S	Prokaryotic homologs of the JAB domain	-	-	-	-	-	-	-	-	-	-	-	-	Prok-JAB
MMS3_k127_4158927_3	673860.AciM339_0973	2.335e-46	188.0	COG0061@1|root,arCOG01348@2157|Archaea,2XTP6@28890|Euryarchaeota,3F32I@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	GO:0000166,GO:0003674,GO:0003824,GO:0003951,GO:0005488,GO:0005524,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006741,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009987,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016787,GO:0016788,GO:0016791,GO:0017076,GO:0018130,GO:0019178,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042578,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	Inositol_P,NAD_kinase
MMS3_k127_4158927_2	1054217.TALC_01451	1.89e-50	190.0	COG0061@1|root,COG0483@1|root,arCOG01348@2157|Archaea,arCOG01349@2157|Archaea,2XTP6@28890|Euryarchaeota,241Q7@183967|Thermoplasmata	183967|Thermoplasmata	F	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
MMS3_k127_4158927_1	673860.AciM339_0074	6.913e-119	405.0	COG1236@1|root,arCOG00541@2157|Archaea,2XTIU@28890|Euryarchaeota,3F2F9@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Beta-Casp domain	epf1	-	-	ko:K07577	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,Lactamase_B_2,Lactamase_B_6,RMMBL
MMS3_k127_4158927_9	368407.Memar_2068	1.167e-08	64.0	COG3398@1|root,arCOG02611@2157|Archaea	368407.Memar_2068|-	K	protein conserved in archaea	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_4158927_4	439481.Aboo_0093	1.624e-40	164.0	COG1084@1|root,arCOG00352@2157|Archaea,2XU5R@28890|Euryarchaeota,3F2J9@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Nucleolar GTP-binding protein 1 (NOG1)	gbp4	-	-	ko:K06943	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	MMR_HSR1,NOG1
MMS3_k127_4192971_5	1051632.TPY_3236	4.325e-96	326.0	COG1249@1|root,COG1249@2|Bacteria,1TP1W@1239|Firmicutes,249R3@186801|Clostridia,3WCDU@538999|Clostridiales incertae sedis	186801|Clostridia	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	lpdA	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
MMS3_k127_4192971_12	243231.GSU2434	1.248e-50	196.0	COG0321@1|root,COG0321@2|Bacteria,1MU6A@1224|Proteobacteria,42RIC@68525|delta/epsilon subdivisions,2WNRX@28221|Deltaproteobacteria,43TUS@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate	lipB	GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564	2.3.1.181	ko:K03801	ko00785,ko01100,map00785,map01100	-	R07766,R07769	RC00039,RC00992,RC02867	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
MMS3_k127_4192971_17	1382306.JNIM01000001_gene787	6.672e-23	112.0	COG0702@1|root,COG0702@2|Bacteria	2|Bacteria	GM	epimerase	-	-	1.6.5.3,1.6.99.3	ko:K00329,ko:K00356	ko00190,map00190	-	R11945	RC00061	ko00000,ko00001,ko01000	-	-	-	NAD_binding_10
MMS3_k127_4192971_21	933262.AXAM01000005_gene2447	6.763e-09	68.0	COG2810@1|root,COG2810@2|Bacteria	2|Bacteria	V	amidase activity	-	-	-	ko:K07504	-	-	-	-	ko00000	-	-	-	DUF4357,HSDR_N_2,TerD
MMS3_k127_4192971_16	1122917.KB899660_gene1683	6.9e-27	127.0	COG4359@1|root,COG4359@2|Bacteria,1TSZ9@1239|Firmicutes,4H9ZE@91061|Bacilli,26S8J@186822|Paenibacillaceae	91061|Bacilli	E	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)	mtnX	-	3.1.3.87	ko:K08966	ko00270,ko01100,map00270,map01100	M00034	R07394	RC02074	ko00000,ko00001,ko00002,ko01000	-	-	iYO844.BSU13600	HAD
MMS3_k127_4192971_2	1041930.Mtc_0628	1.3e-125	413.0	COG1089@1|root,arCOG01373@2157|Archaea,2XUVY@28890|Euryarchaeota,2N9AM@224756|Methanomicrobia	224756|Methanomicrobia	M	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose	gmd	-	4.2.1.47	ko:K01711	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R00888	RC00402	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
MMS3_k127_4192971_4	867903.ThesuDRAFT_00527	1.141e-101	344.0	COG2046@1|root,COG2046@2|Bacteria,1TR4C@1239|Firmicutes,249ZJ@186801|Clostridia,3WDAR@538999|Clostridiales incertae sedis	186801|Clostridia	H	Belongs to the sulfate adenylyltransferase family	sat	-	2.7.7.4	ko:K00958	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-sulfurylase,PUA_2
MMS3_k127_4192971_20	324602.Caur_1384	1.828e-11	75.0	COG1184@1|root,COG1184@2|Bacteria,2G9CC@200795|Chloroflexi,3762Q@32061|Chloroflexia	32061|Chloroflexia	J	Belongs to the eIF-2B alpha beta delta subunits family	-	-	-	ko:K03680	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	IF-2B
MMS3_k127_4192971_13	273075.Ta1385	2.44e-48	199.0	arCOG05967@1|root,arCOG05967@2157|Archaea,2Y4T4@28890|Euryarchaeota,242CC@183967|Thermoplasmata	183967|Thermoplasmata	S	Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A	-	-	-	-	-	-	-	-	-	-	-	-	PNGaseA
MMS3_k127_4192971_10	1230476.C207_01401	4.02e-53	200.0	COG0730@1|root,COG0730@2|Bacteria,1PK9F@1224|Proteobacteria,2TRK3@28211|Alphaproteobacteria,3JVTD@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Sulfite exporter TauE/SafE	-	-	-	-	-	-	-	-	-	-	-	-	TauE
MMS3_k127_4192971_11	1380386.JIAW01000007_gene3788	3.768e-51	198.0	COG0500@1|root,COG2226@2|Bacteria,2GJSF@201174|Actinobacteria,23B1Y@1762|Mycobacteriaceae	201174|Actinobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
MMS3_k127_4192971_8	1382306.JNIM01000001_gene2725	1.758e-63	228.0	COG0730@1|root,COG4272@1|root,COG0730@2|Bacteria,COG4272@2|Bacteria,2G6ZH@200795|Chloroflexi	200795|Chloroflexi	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	DUF1634,TauE
MMS3_k127_4192971_14	572478.Vdis_1970	1.663e-46	177.0	COG2086@1|root,arCOG00446@2157|Archaea,2XS2H@28889|Crenarchaeota	28889|Crenarchaeota	C	Electron transfer flavoprotein domain	-	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
MMS3_k127_4192971_9	666510.ASAC_1290	3.474e-56	214.0	COG2025@1|root,arCOG00447@2157|Archaea,2XQJK@28889|Crenarchaeota	28889|Crenarchaeota	C	electron transfer flavoprotein, alpha subunit	etfA	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
MMS3_k127_4192971_3	579405.Dd703_1397	3.008e-102	352.0	COG0644@1|root,COG0644@2|Bacteria,1MVU6@1224|Proteobacteria,1RNY5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Electron transfer flavoprotein-ubiquinone oxidoreductase	ydiS	-	-	ko:K00313	-	-	-	-	ko00000,ko01000	-	-	-	DAO,FAD_binding_2,FAD_binding_3,Thi4
MMS3_k127_4192971_18	1382304.JNIL01000001_gene2982	5.088e-22	102.0	COG2440@1|root,COG2440@2|Bacteria,1V6DH@1239|Firmicutes,4HII2@91061|Bacilli,27A5Q@186823|Alicyclobacillaceae	91061|Bacilli	C	Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S	-	-	-	ko:K03855	-	-	-	-	ko00000	-	-	-	ETF_QO
MMS3_k127_4192971_15	768671.ThimaDRAFT_4551	6.464e-44	166.0	COG1146@1|root,COG1146@2|Bacteria,1R4GP@1224|Proteobacteria,1RXXW@1236|Gammaproteobacteria,1WVWW@135613|Chromatiales	135613|Chromatiales	C	reductase beta subunit	-	-	1.8.99.2	ko:K00395	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00596	R00860,R04927,R08553	RC00007,RC01239,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	APS-reductase_C,Fer4,Fer4_9
MMS3_k127_4192971_0	466038.KI421440_gene832	2.007e-242	767.0	COG1053@1|root,COG1053@2|Bacteria,1NZBR@1224|Proteobacteria,2TSN4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	succinate dehydrogenase fumarate reductase, flavoprotein subunit	MA20_14860	-	1.8.99.2	ko:K00394	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00596	R00860,R04927,R08553	RC00007,RC01239,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
MMS3_k127_4192971_19	655981.L8FSK9	1.587e-17	97.0	COG0639@1|root,KOG0374@2759|Eukaryota,38BGF@33154|Opisthokonta,3NUEW@4751|Fungi,3QMXQ@4890|Ascomycota,20VP1@147548|Leotiomycetes	4751|Fungi	T	serine threonine-protein phosphatase	pzh1	GO:0000322,GO:0000323,GO:0000324,GO:0003674,GO:0003824,GO:0004721,GO:0004722,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005773,GO:0005886,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0006873,GO:0006875,GO:0006883,GO:0007154,GO:0007165,GO:0008104,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019538,GO:0019725,GO:0019897,GO:0019898,GO:0023052,GO:0030003,GO:0030004,GO:0033036,GO:0034613,GO:0036211,GO:0042578,GO:0042592,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0048878,GO:0050789,GO:0050794,GO:0050801,GO:0050896,GO:0051179,GO:0051641,GO:0051716,GO:0055065,GO:0055067,GO:0055078,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0070727,GO:0071704,GO:0071944,GO:0098771,GO:0140096,GO:1901564	3.1.3.16	ko:K06269	ko03015,ko04022,ko04024,ko04113,ko04114,ko04218,ko04261,ko04270,ko04390,ko04510,ko04611,ko04720,ko04728,ko04750,ko04810,ko04910,ko04921,ko04931,ko05031,ko05034,ko05168,ko05205,map03015,map04022,map04024,map04113,map04114,map04218,map04261,map04270,map04390,map04510,map04611,map04720,map04728,map04750,map04810,map04910,map04921,map04931,map05031,map05034,map05168,map05205	-	-	-	ko00000,ko00001,ko01000,ko01009,ko03019,ko03021,ko03041	-	-	-	Metallophos,STPPase_N
MMS3_k127_4192971_7	273057.SSO1127	1.208e-70	248.0	COG2048@1|root,arCOG00965@2157|Archaea	2157|Archaea	C	heterodisulfide reductase, subunit	hdrC-1	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03390,ko:K22482	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_17,Fer4_8
MMS3_k127_4192971_1	273057.SSO1129	2.154e-146	501.0	COG2048@1|root,arCOG00342@2157|Archaea	2157|Archaea	C	PFAM Cysteine-rich domain	hdrB-1	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389,ko:K22481	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A1954	CCG
MMS3_k127_4192971_6	932678.THERU_00175	4.256e-78	291.0	COG1148@1|root,COG1148@2|Bacteria,2G5GN@200783|Aquificae	200783|Aquificae	C	Pyridine nucleotide-disulphide oxidoreductase	hdrA	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Pyr_redox_2
MMS3_k127_4227811_5	273063.STK_15620	4.756e-06	56.0	COG3432@1|root,arCOG01055@2157|Archaea	2157|Archaea	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_45
MMS3_k127_4227811_4	935557.ATYB01000014_gene1964	1.889e-09	65.0	COG1846@1|root,COG1846@2|Bacteria,1RH1F@1224|Proteobacteria,2U9GN@28211|Alphaproteobacteria,4BDZ9@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	transcriptional regulator	ohrR	GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044212,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141	-	-	-	-	-	-	-	-	-	-	MarR
MMS3_k127_4227811_1	1054217.TALC_00024	1.916e-67	244.0	COG1131@1|root,arCOG00196@2157|Archaea,2Y7KH@28890|Euryarchaeota,242I8@183967|Thermoplasmata	28890|Euryarchaeota	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
MMS3_k127_4227811_2	673860.AciM339_0255	4.384e-39	157.0	COG1277@1|root,arCOG03689@2157|Archaea,2Y0MI@28890|Euryarchaeota,3F2VX@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
MMS3_k127_4227811_0	263820.PTO0162	1.703e-146	481.0	arCOG00144@1|root,arCOG00144@2157|Archaea,2XUGF@28890|Euryarchaeota,24238@183967|Thermoplasmata	28890|Euryarchaeota	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS3_k127_4227811_3	1236689.MMALV_16080	5.21e-21	103.0	arCOG03776@1|root,arCOG03776@2157|Archaea,2Y2C3@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_4229391_3	1048339.KB913029_gene734	1.659e-05	58.0	COG0515@1|root,COG0642@1|root,COG3899@1|root,COG0515@2|Bacteria,COG0642@2|Bacteria,COG2205@2|Bacteria,COG3899@2|Bacteria,2HFBH@201174|Actinobacteria,4EUB9@85013|Frankiales	201174|Actinobacteria	T	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,HATPase_c,Pkinase
MMS3_k127_4229391_0	1379698.RBG1_1C00001G0709	5.856e-67	254.0	COG1899@1|root,COG1899@2|Bacteria,2NR8I@2323|unclassified Bacteria	2|Bacteria	O	Deoxyhypusine synthase	-	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008612,GO:0009058,GO:0009987,GO:0010467,GO:0016740,GO:0016765,GO:0018193,GO:0018205,GO:0019538,GO:0034038,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051604,GO:0071704,GO:1901564	2.5.1.46	ko:K00809	-	-	-	-	ko00000,ko01000	-	-	-	DS
MMS3_k127_4229391_1	644966.Tmar_1357	2.004e-62	221.0	COG2041@1|root,COG2041@2|Bacteria,1UMMR@1239|Firmicutes,24QVC@186801|Clostridia	186801|Clostridia	S	PFAM Oxidoreductase, molybdopterin binding	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_molyb
MMS3_k127_4229391_2	1380390.JIAT01000013_gene125	1.133e-06	61.0	COG2909@1|root,COG2909@2|Bacteria,2GJXF@201174|Actinobacteria,4CQYN@84995|Rubrobacteria	84995|Rubrobacteria	K	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
MMS3_k127_425426_11	1125863.JAFN01000001_gene2836	1.409e-44	169.0	COG1014@1|root,COG1014@2|Bacteria,1N12F@1224|Proteobacteria,42NN1@68525|delta/epsilon subdivisions,2WNNF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	-	-	1.2.7.1	ko:K00172	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
MMS3_k127_425426_16	593117.TGAM_0266	8.591e-21	105.0	COG1144@1|root,arCOG01605@2157|Archaea,2Y02N@28890|Euryarchaeota,244AY@183968|Thermococci	183968|Thermococci	C	4Fe-4S dicluster domain	vorD	-	1.2.7.7	ko:K00188	ko00280,ko01100,map00280,map01100	-	R07160,R08566,R08567	RC00004,RC02833,RC02856	br01601,ko00000,ko00001,ko01000	-	-	-	Fer4
MMS3_k127_425426_1	391623.TERMP_01558	6.992e-112	379.0	COG0674@1|root,arCOG01608@2157|Archaea,2XTB0@28890|Euryarchaeota,242N1@183968|Thermococci	183968|Thermococci	C	3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) activity	vorA	-	1.2.7.7	ko:K00186	ko00280,ko01100,map00280,map01100	-	R07160,R08566,R08567	RC00004,RC02833,RC02856	br01601,ko00000,ko00001,ko01000	-	-	-	PFOR_II,POR_N
MMS3_k127_425426_3	439481.Aboo_0301	4.494e-104	346.0	COG1013@1|root,arCOG01601@2157|Archaea,2XT3E@28890|Euryarchaeota,3F2JH@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	vorB	-	1.2.7.1,1.2.7.7	ko:K00170,ko:K00187	ko00010,ko00020,ko00280,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00280,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R07160,R08034,R08566,R08567	RC00004,RC00250,RC02742,RC02833,RC02856	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
MMS3_k127_425426_9	1417296.U879_03685	1.517e-57	215.0	COG0500@1|root,COG2226@2|Bacteria,1R41W@1224|Proteobacteria,2UJDA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Mycolic acid cyclopropane synthetase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
MMS3_k127_425426_4	1417296.U879_03690	8.92e-102	363.0	COG1145@1|root,COG1456@1|root,COG1145@2|Bacteria,COG1456@2|Bacteria,1R6BH@1224|Proteobacteria,2USUR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	CO dehydrogenase/acetyl-CoA synthase delta subunit	-	-	-	-	-	-	-	-	-	-	-	-	CdhD,Fer4
MMS3_k127_425426_14	234267.Acid_4185	1.492e-26	114.0	COG4106@1|root,COG4106@2|Bacteria	2|Bacteria	FG	trans-aconitate 2-methyltransferase activity	tam	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0030798,GO:0032259,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0051704	2.1.1.144,2.1.1.197	ko:K00598,ko:K02169	ko00780,ko01100,map00780,map01100	M00572	R09543	RC00003,RC00460	ko00000,ko00001,ko00002,ko01000	-	-	iECABU_c1320.ECABU_c17460,iSDY_1059.SDY_1625,ic_1306.c1942	Methyltransf_23,Methyltransf_25,Methyltransf_31
MMS3_k127_425426_21	666510.ASAC_0649	2.139e-08	68.0	arCOG02545@1|root,arCOG06052@1|root,arCOG02545@2157|Archaea,arCOG06052@2157|Archaea,2XSHA@28889|Crenarchaeota	28889|Crenarchaeota	S	parallel beta-helix repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_425426_6	1519464.HY22_11920	1.458e-75	288.0	COG3391@1|root,COG4412@1|root,COG3391@2|Bacteria,COG4412@2|Bacteria	2|Bacteria	S	peptidase activity, acting on L-amino acid peptides	-	-	-	ko:K20276,ko:K21449	ko02024,map02024	-	-	-	ko00000,ko00001,ko02000	1.B.40.2	-	-	CARDB,FTP,He_PIG,NHL,PA,Peptidase_M30,Peptidase_M36,Peptidase_M6
MMS3_k127_425426_20	326424.FRAAL6628	1.47e-11	79.0	COG1361@1|root,COG3468@1|root,COG4719@1|root,COG1361@2|Bacteria,COG3468@2|Bacteria,COG4719@2|Bacteria,2I8F1@201174|Actinobacteria	201174|Actinobacteria	M	cellulase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,He_PIG,fn3
MMS3_k127_425426_19	589924.Ferp_2229	1.409e-12	69.0	COG1998@1|root,arCOG04183@2157|Archaea,2Y11U@28890|Euryarchaeota,246I6@183980|Archaeoglobi	183980|Archaeoglobi	J	Belongs to the eukaryotic ribosomal protein eS31 family	rps27ae	-	-	ko:K02977	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko04147	-	-	-	Ribosomal_S27
MMS3_k127_425426_17	439481.Aboo_0565	3.806e-19	91.0	COG2004@1|root,arCOG04182@2157|Archaea,2Y6EY@28890|Euryarchaeota,3F2VW@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Belongs to the eukaryotic ribosomal protein eS24 family	rps24e	-	-	ko:K02974	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S24e
MMS3_k127_425426_15	1227484.C471_06023	1.761e-21	101.0	COG1909@1|root,arCOG04076@2157|Archaea,2XXSG@28890|Euryarchaeota,23W2W@183963|Halobacteria	183963|Halobacteria	S	Belongs to the UPF0218 family	-	-	-	ko:K09735	-	-	-	-	ko00000	-	-	-	DUF359
MMS3_k127_425426_18	1236689.MMALV_04380	3.93e-17	87.0	COG2093@1|root,arCOG04077@2157|Archaea,2Y6YF@28890|Euryarchaeota,3F2W7@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	Transcription elongation factor Spt4	spt4	-	2.7.7.6	ko:K03050	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	Spt4
MMS3_k127_425426_8	1236689.MMALV_04370	1.435e-61	219.0	COG1095@1|root,arCOG00675@2157|Archaea,2XT6U@28890|Euryarchaeota,3F2MN@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397	rpoE1	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03049	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	S1,SHS2_Rpb7-N
MMS3_k127_425426_5	694429.Pyrfu_1285	2.293e-94	342.0	COG0057@1|root,arCOG00493@2157|Archaea,2XPUB@28889|Crenarchaeota	28889|Crenarchaeota	G	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	gap	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	1.2.1.59	ko:K00150	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166	R01061,R01063	RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_N,Gp_dh_C
MMS3_k127_425426_2	671065.MetMK1DRAFT_00019200	5.299e-110	368.0	COG1960@1|root,arCOG04310@2157|Archaea,2XPUV@28889|Crenarchaeota	28889|Crenarchaeota	I	PFAM acyl-CoA dehydrogenase domain protein	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
MMS3_k127_425426_12	113395.AXAI01000004_gene4425	1.697e-34	146.0	COG0611@1|root,COG0611@2|Bacteria,1MU9X@1224|Proteobacteria,2TTI6@28211|Alphaproteobacteria,3JQYI@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
MMS3_k127_425426_7	1459636.NTE_02001	7.899e-62	236.0	COG1131@1|root,arCOG00194@2157|Archaea	2157|Archaea	V	ABC-type multidrug transport system ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
MMS3_k127_425426_13	985053.VMUT_1693	4.207e-30	138.0	COG0842@1|root,arCOG01469@2157|Archaea,2XRBH@28889|Crenarchaeota	28889|Crenarchaeota	P	ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
MMS3_k127_425426_0	525904.Tter_0805	9.972e-172	548.0	COG0334@1|root,COG0334@2|Bacteria,2NNRJ@2323|unclassified Bacteria	2|Bacteria	E	Belongs to the Glu Leu Phe Val dehydrogenases family	gdhA	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
MMS3_k127_425426_10	593117.TGAM_1646	3.077e-49	186.0	COG2236@1|root,arCOG00040@2157|Archaea,2XU0E@28890|Euryarchaeota,24312@183968|Thermococci	183968|Thermococci	F	Phosphoribosyl transferase domain	-	-	-	ko:K07101	-	-	-	-	ko00000	-	-	-	Pribosyltran
MMS3_k127_425426_22	439481.Aboo_1186	6.585e-05	52.0	COG2237@1|root,arCOG04151@2157|Archaea,2XTV5@28890|Euryarchaeota,3F2NQ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Domain of unknown function (DUF373)	-	-	-	ko:K08975	-	-	-	-	ko00000	-	-	-	DUF373
MMS3_k127_4285800_1	1045855.DSC_11205	6.724e-55	207.0	COG0111@1|root,COG0111@2|Bacteria,1NU4B@1224|Proteobacteria,1T1T1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	EH	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	-	-	1.1.1.310,1.1.1.399,1.1.1.95	ko:K00058,ko:K16843	ko00260,ko00270,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513,R05693	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
MMS3_k127_4285800_2	1122921.KB898191_gene2007	7.53e-33	141.0	COG0457@1|root,COG3210@1|root,COG5492@1|root,COG0457@2|Bacteria,COG3210@2|Bacteria,COG5492@2|Bacteria,1UI3P@1239|Firmicutes,4HJMZ@91061|Bacilli,27713@186822|Paenibacillaceae	2|Bacteria	GN	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Big_2,Cadherin-like,CarboxypepD_reg,Flg_new,Laminin_G_3,PATR,SLH,fn3
MMS3_k127_4285800_0	880526.KE386488_gene68	4.246e-78	278.0	COG0493@1|root,COG0493@2|Bacteria,4NG9R@976|Bacteroidetes,2FMJF@200643|Bacteroidia,22UAN@171550|Rikenellaceae	976|Bacteroidetes	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	gltA	-	1.3.1.1,1.4.1.13,1.4.1.14	ko:K00266,ko:K17722	ko00240,ko00250,ko00410,ko00770,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00240,map00250,map00410,map00770,map00910,map01100,map01110,map01120,map01130,map01230	M00046	R00093,R00114,R00248,R00977,R01414,R11026	RC00006,RC00010,RC00072,RC00123,RC02799	ko00000,ko00001,ko00002,ko01000	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,Fer4_20,NAD_binding_1,Pyr_redox_2
MMS3_k127_49234_7	439481.Aboo_1516	1.867e-16	83.0	COG0091@1|root,arCOG04098@2157|Archaea,2XWGN@28890|Euryarchaeota,3F2TW@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rpl22	-	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
MMS3_k127_49234_4	673860.AciM339_1102	1.897e-41	156.0	COG0185@1|root,arCOG04099@2157|Archaea,2XWI9@28890|Euryarchaeota,3F2NY@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rps19p	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
MMS3_k127_49234_3	439481.Aboo_1518	1.836e-54	203.0	COG0090@1|root,arCOG04067@2157|Archaea,2XTCS@28890|Euryarchaeota,3F2KT@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Ribosomal Proteins L2, C-terminal domain	rpl2	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
MMS3_k127_49234_9	679926.Mpet_2190	3.9e-05	55.0	COG0089@1|root,arCOG04072@2157|Archaea,2XYPG@28890|Euryarchaeota,2N9ZC@224756|Methanomicrobia	224756|Methanomicrobia	J	Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome	rpl23	-	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
MMS3_k127_49234_2	1236689.MMALV_14250	1.641e-58	219.0	COG0469@1|root,arCOG04071@2157|Archaea,2XTXX@28890|Euryarchaeota,3F2K6@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Forms part of the polypeptide exit tunnel	rpl4	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02930	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
MMS3_k127_49234_0	673860.AciM339_1098	1.192e-110	366.0	COG0087@1|root,arCOG04070@2157|Archaea,2XT9B@28890|Euryarchaeota,3F2H1@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rpl3	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
MMS3_k127_49234_6	1123389.ATXJ01000008_gene2144	1.261e-18	92.0	COG4911@1|root,COG4911@2|Bacteria,1WJWB@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Uncharacterized conserved protein (DUF2203)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2203
MMS3_k127_49234_5	439481.Aboo_1283	2.197e-23	115.0	COG1628@1|root,arCOG00928@2157|Archaea,2XXBV@28890|Euryarchaeota,3F36M@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Belongs to the UPF0215 family	-	-	-	ko:K09120	-	-	-	-	ko00000	-	-	-	DUF99
MMS3_k127_49234_8	408672.NBCG_03625	5.603e-13	81.0	COG1721@1|root,COG1721@2|Bacteria,2GK9A@201174|Actinobacteria,4DPK5@85009|Propionibacteriales	201174|Actinobacteria	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,DUF58
MMS3_k127_49234_1	562970.Btus_0260	1.233e-80	287.0	COG0714@1|root,COG0714@2|Bacteria,1TPKR@1239|Firmicutes,4HA0T@91061|Bacilli,27829@186823|Alicyclobacillaceae	91061|Bacilli	S	PFAM ATPase associated with various cellular activities AAA_3	yeaC	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
MMS3_k127_523735_3	1121405.dsmv_3828	6.478e-61	220.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,42M6J@68525|delta/epsilon subdivisions,2WJZQ@28221|Deltaproteobacteria,2MJ1A@213118|Desulfobacterales	28221|Deltaproteobacteria	I	PFAM 3-hydroxyacyl-CoA dehydrogenase	-	-	1.1.1.157,1.1.1.35,4.2.1.17	ko:K00074,ko:K15016	ko00360,ko00362,ko00650,ko00720,ko01100,ko01120,ko01200,map00360,map00362,map00650,map00720,map01100,map01120,map01200	M00374,M00375	R01975,R01976,R03026,R05576,R06941	RC00029,RC00117,RC00831	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N
MMS3_k127_523735_2	1128421.JAGA01000003_gene3228	2.055e-85	319.0	COG0604@1|root,COG0604@2|Bacteria,2NP5I@2323|unclassified Bacteria	2|Bacteria	C	PFAM Alcohol dehydrogenase, zinc-binding	-	-	1.1.1.1	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
MMS3_k127_523735_0	1123288.SOV_2c09600	7.11e-116	389.0	COG0215@1|root,COG0215@2|Bacteria,1TP9D@1239|Firmicutes,4H25E@909932|Negativicutes	909932|Negativicutes	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e,tRNA-synt_1g
MMS3_k127_523735_1	1211114.ALIP01000105_gene1718	1.846e-95	320.0	COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,1RMCV@1236|Gammaproteobacteria,1X4AH@135614|Xanthomonadales	135614|Xanthomonadales	E	cystathionine	-	-	4.4.1.1	ko:K01758	ko00260,ko00270,ko00450,ko01100,ko01130,ko01230,map00260,map00270,map00450,map01100,map01130,map01230	M00338	R00782,R01001,R02408,R04770,R04930,R09366	RC00056,RC00069,RC00348,RC00382,RC00710,RC01209,RC01210,RC01245,RC02303	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Cys_Met_Meta_PP
MMS3_k127_526462_1	1380393.JHVP01000003_gene1166	9.53e-109	359.0	COG0379@1|root,COG0379@2|Bacteria,2GM59@201174|Actinobacteria,4ESYU@85013|Frankiales	201174|Actinobacteria	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0030312,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	-	NadA
MMS3_k127_526462_4	368407.Memar_0821	2.78e-47	183.0	COG0157@1|root,arCOG01482@2157|Archaea,2XTTY@28890|Euryarchaeota,2N950@224756|Methanomicrobia	224756|Methanomicrobia	H	Involved in the catabolism of quinolinic acid (QA)	nadC	-	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A1867	QRPTase_C,QRPTase_N
MMS3_k127_526462_6	28444.JODQ01000001_gene2611	1.158e-28	134.0	COG3629@1|root,COG3899@1|root,COG3629@2|Bacteria,COG3899@2|Bacteria,2I2U4@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD,GerE,Trans_reg_C
MMS3_k127_526462_3	221360.RS9917_06175	3.043e-72	273.0	COG0404@1|root,COG0404@2|Bacteria,1G0GR@1117|Cyanobacteria,1GYU4@1129|Synechococcus	1117|Cyanobacteria	E	The glycine cleavage system catalyzes the degradation of glycine	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
MMS3_k127_526462_0	269797.Mbar_A0288	1.506e-125	412.0	COG1759@1|root,arCOG04346@2157|Archaea,2XUFR@28890|Euryarchaeota,2N9HE@224756|Methanomicrobia	224756|Methanomicrobia	F	Protein of unknown function (DUF1246)	-	-	6.3.4.23	ko:K06863	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R06975	RC00263,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1246,DUF1297
MMS3_k127_526462_2	1382356.JQMP01000001_gene704	1.436e-108	383.0	COG1529@1|root,COG1529@2|Bacteria,2G65D@200795|Chloroflexi,27Y2Q@189775|Thermomicrobia	189775|Thermomicrobia	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
MMS3_k127_526462_5	338966.Ppro_1513	2.129e-38	148.0	COG2080@1|root,COG2080@2|Bacteria,1MWA6@1224|Proteobacteria,42RRP@68525|delta/epsilon subdivisions,2WP0I@28221|Deltaproteobacteria,43W3D@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	2Fe-2S -binding domain protein	-	-	1.2.5.3	ko:K03518,ko:K13483	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103,R11168	RC00143,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2,Fer2_2
MMS3_k127_540607_1	985053.VMUT_1168	5.002e-143	470.0	COG0160@1|root,arCOG00915@2157|Archaea,2XPTE@28889|Crenarchaeota	28889|Crenarchaeota	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.19,2.6.1.76	ko:K00823,ko:K00836	ko00250,ko00260,ko00410,ko00640,ko00650,ko01100,ko01120,ko01210,ko01230,map00250,map00260,map00410,map00640,map00650,map01100,map01120,map01210,map01230	M00027,M00033	R00908,R01648,R06977	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
MMS3_k127_540607_2	374847.Kcr_0329	1.696e-137	455.0	COG0001@1|root,arCOG00918@2157|Archaea	2157|Archaea	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
MMS3_k127_540607_3	880073.Calab_0088	1.665e-13	77.0	COG1012@1|root,COG1012@2|Bacteria,2NNVP@2323|unclassified Bacteria	2|Bacteria	C	Aldehyde dehydrogenase family	pruA	-	1.2.1.88	ko:K00294	ko00250,ko00330,ko01100,map00250,map00330,map01100	-	R00245,R00707,R00708,R04444,R04445,R05051	RC00080,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000	-	-	-	Aldedh
MMS3_k127_540607_0	1304874.JAFY01000002_gene457	3.293e-174	557.0	COG1012@1|root,COG1012@2|Bacteria,3TARH@508458|Synergistetes	508458|Synergistetes	C	1-pyrroline-5-carboxylate dehydrogenase	-	-	1.2.1.88	ko:K00294	ko00250,ko00330,ko01100,map00250,map00330,map01100	-	R00245,R00707,R00708,R04444,R04445,R05051	RC00080,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000	-	-	-	Aldedh
MMS3_k127_592681_3	331869.BAL199_22044	7.576e-13	81.0	COG0546@1|root,COG0546@2|Bacteria,1RDA7@1224|Proteobacteria,2U703@28211|Alphaproteobacteria,4BQR3@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	HAD-hyrolase-like	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
MMS3_k127_592681_2	1236689.MMALV_01380	5.521e-81	298.0	COG0452@1|root,arCOG01704@2157|Archaea,2XTZK@28890|Euryarchaeota,3F2J3@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	dfp	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
MMS3_k127_592681_1	760568.Desku_1360	3.876e-100	338.0	COG0045@1|root,COG0045@2|Bacteria,1TQG4@1239|Firmicutes,249ED@186801|Clostridia,260DW@186807|Peptococcaceae	186801|Clostridia	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
MMS3_k127_592681_0	1382356.JQMP01000003_gene1858	7.988e-109	371.0	COG0074@1|root,COG0074@2|Bacteria,2G5R4@200795|Chloroflexi,27XS4@189775|Thermomicrobia	189775|Thermomicrobia	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA
MMS3_k127_59853_3	797303.Natpe_3350	1.853e-22	103.0	arCOG03850@1|root,arCOG03850@2157|Archaea,2XZTT@28890|Euryarchaeota,23Y39@183963|Halobacteria	183963|Halobacteria	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_24
MMS3_k127_59853_0	1054217.TALC_01148	9.381e-67	247.0	COG0585@1|root,arCOG04252@2157|Archaea,2XUTK@28890|Euryarchaeota,241NZ@183967|Thermoplasmata	183967|Thermoplasmata	J	Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs	truD	-	5.4.99.27	ko:K06176	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruD
MMS3_k127_59853_2	1227487.C474_05900	2.8e-35	153.0	arCOG01172@1|root,arCOG01172@2157|Archaea,2XTWD@28890|Euryarchaeota,23U9K@183963|Halobacteria	183963|Halobacteria	S	COG0467 RecA-superfamily ATPases implicated in signal transduction	htlC	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_59853_1	673860.AciM339_0493	7.29e-55	200.0	COG0467@1|root,arCOG01173@2157|Archaea,2XTF1@28890|Euryarchaeota	28890|Euryarchaeota	T	COG0467 RecA-superfamily ATPases implicated in signal transduction	-	-	-	-	-	-	-	-	-	-	-	-	ATPase
MMS3_k127_609198_14	589924.Ferp_1728	1.946e-17	89.0	COG1581@1|root,arCOG01753@2157|Archaea,2XZH4@28890|Euryarchaeota,246D0@183980|Archaeoglobi	183980|Archaeoglobi	K	Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes	-	-	-	ko:K03622	-	-	-	-	ko00000	-	-	-	Alba
MMS3_k127_609198_18	10160.XP_004634224.1	0.0002935	50.0	COG0456@1|root,KOG3139@2759|Eukaryota,39YBU@33154|Opisthokonta,3BNE3@33208|Metazoa,3D64F@33213|Bilateria,480IP@7711|Chordata,4921S@7742|Vertebrata,3JBJJ@40674|Mammalia,35FJI@314146|Euarchontoglires,4Q4GM@9989|Rodentia	33208|Metazoa	S	N-acetyltransferase	NAT8B	GO:0001702,GO:0003674,GO:0003824,GO:0004468,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005789,GO:0005793,GO:0005794,GO:0006464,GO:0006473,GO:0006475,GO:0006518,GO:0006575,GO:0006749,GO:0006790,GO:0006807,GO:0007162,GO:0007275,GO:0007368,GO:0007369,GO:0007389,GO:0007507,GO:0008080,GO:0008150,GO:0008152,GO:0009653,GO:0009790,GO:0009799,GO:0009855,GO:0009893,GO:0009987,GO:0010468,GO:0010604,GO:0010628,GO:0010941,GO:0012505,GO:0016020,GO:0016021,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0018003,GO:0018193,GO:0018205,GO:0018393,GO:0018394,GO:0019222,GO:0019538,GO:0030155,GO:0031090,GO:0031224,GO:0031984,GO:0032501,GO:0032502,GO:0033116,GO:0034641,GO:0036211,GO:0042175,GO:0042981,GO:0043066,GO:0043067,GO:0043069,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0043543,GO:0043603,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0047198,GO:0048513,GO:0048518,GO:0048519,GO:0048523,GO:0048598,GO:0048731,GO:0048856,GO:0050435,GO:0050789,GO:0050794,GO:0051186,GO:0060255,GO:0060548,GO:0065007,GO:0071704,GO:0072359,GO:0098588,GO:0098827,GO:1901564	2.3.1.80	ko:K20838	ko00480,map00480	-	R04950	RC00004,RC00064	ko00000,ko00001,ko01000	-	-	-	Acetyltransf_1
MMS3_k127_609198_2	1042877.GQS_10700	2.801e-112	381.0	COG0017@1|root,arCOG00407@2157|Archaea,2XTZJ@28890|Euryarchaeota,242NW@183968|Thermococci	183968|Thermococci	J	Belongs to the class-II aminoacyl-tRNA synthetase family	asnS	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.1.1.22	ko:K01893	ko00970,map00970	M00359,M00360	R03648	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
MMS3_k127_609198_13	647113.Metok_0144	3.116e-25	108.0	COG1594@1|root,arCOG00579@2157|Archaea,2XY3E@28890|Euryarchaeota,23R2W@183939|Methanococci	183939|Methanococci	K	Belongs to the archaeal rpoM eukaryotic RPA12 RPB9 RPC11 RNA polymerase family	-	GO:0000428,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006355,GO:0008150,GO:0008270,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0030880,GO:0031323,GO:0031326,GO:0032991,GO:0043167,GO:0043169,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0061695,GO:0065007,GO:0080090,GO:1902494,GO:1903506,GO:1990234,GO:2000112,GO:2001141	-	ko:K03057	ko01100,map01100	-	-	-	br01611,ko00000,ko03021	-	-	-	RNA_POL_M_15KD,TFIIS_C
MMS3_k127_609198_4	1183377.Py04_0507	1.36e-101	348.0	COG0151@1|root,arCOG04415@2157|Archaea,2XTRV@28890|Euryarchaeota,2439T@183968|Thermococci	183968|Thermococci	F	Glycinamide ribonucleotide synthetase	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
MMS3_k127_609198_16	273116.14325701	3.097e-11	67.0	COG1761@1|root,arCOG04111@2157|Archaea,2XZVZ@28890|Euryarchaeota,241XD@183967|Thermoplasmata	183967|Thermoplasmata	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoL	-	2.7.7.6	ko:K03056	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_L_2
MMS3_k127_609198_5	439481.Aboo_0908	5.845e-62	220.0	COG1859@1|root,arCOG04063@2157|Archaea,2XWPC@28890|Euryarchaeota,3F2KG@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase	kptA	-	-	ko:K07559	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PTS_2-RNA
MMS3_k127_609198_7	290397.Adeh_3709	2.217e-58	219.0	COG0477@1|root,COG2814@2|Bacteria,1NE49@1224|Proteobacteria,42PR8@68525|delta/epsilon subdivisions,2WK8J@28221|Deltaproteobacteria	28221|Deltaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS3_k127_609198_1	1071085.KK033114_gene1653	2.814e-124	432.0	COG1012@1|root,arCOG01252@2157|Archaea,2XT1Y@28890|Euryarchaeota,23SU2@183963|Halobacteria	183963|Halobacteria	C	COG1012 NAD-dependent aldehyde dehydrogenases	aldY5	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
MMS3_k127_609198_6	326427.Cagg_0674	5.939e-61	225.0	COG1215@1|root,COG1215@2|Bacteria,2G6RJ@200795|Chloroflexi,375GG@32061|Chloroflexia	32061|Chloroflexia	M	PFAM glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
MMS3_k127_609198_3	593117.TGAM_1167	3.491e-111	381.0	COG1111@1|root,arCOG00872@2157|Archaea,2XTBV@28890|Euryarchaeota,243CX@183968|Thermococci	183968|Thermococci	L	ERCC4 domain	-	-	-	ko:K10896	ko03460,map03460	M00413	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	DEAD,ERCC4,HHH_2,Helicase_C
MMS3_k127_609198_11	1247963.JPHU01000002_gene2611	5.351e-29	121.0	COG0756@1|root,COG0756@2|Bacteria,1RA7P@1224|Proteobacteria,2U7B5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	F	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA	dut	GO:0000287,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576	3.6.1.23	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00053	R02100,R11896	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	dUTPase
MMS3_k127_609198_17	1293048.CBMB010000004_gene2046	0.0001959	55.0	COG3413@1|root,arCOG02276@2157|Archaea,2XX9P@28890|Euryarchaeota,23VUD@183963|Halobacteria	183963|Halobacteria	K	Bacterio-opsin activator	-	-	-	-	-	-	-	-	-	-	-	-	BAT,HTH_10
MMS3_k127_609198_0	643648.Slip_1440	6.879e-161	520.0	COG0043@1|root,COG0043@2|Bacteria,1TQ6V@1239|Firmicutes,248WY@186801|Clostridia,42KET@68298|Syntrophomonadaceae	186801|Clostridia	H	Belongs to the UbiD family	-	-	4.1.1.61,4.1.1.98	ko:K03182,ko:K16239	ko00130,ko00627,ko01100,ko01110,ko01120,map00130,map00627,map01100,map01110,map01120	M00117	R01238,R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
MMS3_k127_609198_10	880072.Desac_1405	3.038e-29	136.0	COG0382@1|root,COG0382@2|Bacteria,1MV4Q@1224|Proteobacteria,42MXH@68525|delta/epsilon subdivisions,2WK8E@28221|Deltaproteobacteria,2MQDP@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	PFAM UbiA prenyltransferase	ubiA	-	2.5.1.39	ko:K03179	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R05000,R05615	RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
MMS3_k127_609198_8	1236689.MMALV_12000	4.488e-58	224.0	COG1549@1|root,arCOG00990@2157|Archaea,2XT9W@28890|Euryarchaeota,3F2KU@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Patch-forming domain C2 of tRNA-guanine transglycosylase	arcS	GO:0002927,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360	2.6.1.97	ko:K07557	-	-	-	-	ko00000,ko01000	-	-	-	PUA,TGT,TGT_C2
MMS3_k127_609198_9	273116.14325755	1.248e-48	192.0	COG0582@1|root,arCOG01241@2157|Archaea,2XWM9@28890|Euryarchaeota	28890|Euryarchaeota	L	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_609198_15	290512.Paes_0780	5.309e-17	93.0	COG3654@1|root,COG3654@2|Bacteria,1FF2G@1090|Chlorobi	1090|Chlorobi	S	TIGRFAM death-on-curing family protein	-	-	-	ko:K07341	-	-	-	-	ko00000,ko02048	-	-	-	Fic
MMS3_k127_609198_12	529709.PYCH_07210	5.844e-28	115.0	COG0863@1|root,arCOG00115@2157|Archaea,2Y6KV@28890|Euryarchaeota,244UT@183968|Thermococci	183968|Thermococci	L	DNA methylase	-	-	2.1.1.113,2.1.1.72	ko:K00571,ko:K00590	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
MMS3_k127_633276_1	70601.3258019	3.275e-30	124.0	COG0020@1|root,arCOG01532@2157|Archaea,2XSW1@28890|Euryarchaeota,242JD@183968|Thermococci	183968|Thermococci	H	Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids	uppS	GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617	2.5.1.89	ko:K15888	ko00900,map00900	-	R09730	RC00279,RC02839	ko00000,ko00001,ko01000	-	-	-	Prenyltransf
MMS3_k127_633276_0	756883.Halar_1615	3.946e-39	159.0	COG0451@1|root,arCOG01376@2157|Archaea	2157|Archaea	M	NAD-dependent epimerase dehydratase	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
MMS3_k127_633276_2	1510531.JQJJ01000015_gene3085	3.838e-29	132.0	COG0438@1|root,COG0438@2|Bacteria,1NB81@1224|Proteobacteria,2U3N3@28211|Alphaproteobacteria,3K615@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
MMS3_k127_63555_10	1342299.Z947_2711	4.963e-07	58.0	COG0546@1|root,COG0546@2|Bacteria,1RDDY@1224|Proteobacteria,2U79T@28211|Alphaproteobacteria,3ZXJW@60136|Sulfitobacter	28211|Alphaproteobacteria	S	haloacid dehalogenase-like hydrolase	gph	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
MMS3_k127_63555_8	1114856.C496_12102	1.235e-23	114.0	COG0492@1|root,arCOG01296@2157|Archaea,2XU1T@28890|Euryarchaeota,23SNC@183963|Halobacteria	183963|Halobacteria	O	COG0492 Thioredoxin reductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_3
MMS3_k127_63555_4	1463881.KL591004_gene3979	4.279e-86	293.0	COG3153@1|root,COG3153@2|Bacteria,2I4HV@201174|Actinobacteria	201174|Actinobacteria	S	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
MMS3_k127_63555_3	694429.Pyrfu_0754	1.566e-101	343.0	COG0505@1|root,arCOG00064@2157|Archaea,2XPZR@28889|Crenarchaeota	28889|Crenarchaeota	F	Belongs to the CarA family	carA	GO:0000050,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005951,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0019627,GO:0019752,GO:0032991,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
MMS3_k127_63555_0	436308.Nmar_1085	0.0	1101.0	COG0458@1|root,arCOG01594@2157|Archaea,41SBF@651137|Thaumarchaeota	651137|Thaumarchaeota	E	MGS-like domain	-	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
MMS3_k127_63555_7	439481.Aboo_0797	7.377e-37	145.0	COG1599@1|root,arCOG01510@2157|Archaea,2Y72Y@28890|Euryarchaeota,3F3AT@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins	-	-	-	ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko03000,ko03032,ko03400	-	-	-	-
MMS3_k127_63555_9	1128421.JAGA01000002_gene667	4.679e-07	61.0	COG0457@1|root,COG5635@1|root,COG0457@2|Bacteria,COG5635@2|Bacteria	2|Bacteria	T	Nacht domain	-	-	-	-	-	-	-	-	-	-	-	-	NACHT,TPR_16,TPR_19,TPR_2,TPR_8,Trypsin_2
MMS3_k127_63555_2	410359.Pcal_1822	1.067e-112	375.0	COG0180@1|root,arCOG01887@2157|Archaea,2XPK1@28889|Crenarchaeota	28889|Crenarchaeota	J	PFAM aminoacyl-tRNA synthetase class Ib	trpS	GO:0003674,GO:0003824,GO:0004812,GO:0004830,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006436,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
MMS3_k127_63555_6	391623.TERMP_00896	9.504e-43	161.0	COG0184@1|root,arCOG04185@2157|Archaea,2XWKV@28890|Euryarchaeota,243T7@183968|Thermococci	183968|Thermococci	J	structural constituent of ribosome	rps15	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13_N,Ribosomal_S15
MMS3_k127_63555_5	1054217.TALC_01455	6.472e-70	263.0	COG0608@1|root,arCOG00427@2157|Archaea,2XW5A@28890|Euryarchaeota,241PR@183967|Thermoplasmata	183967|Thermoplasmata	L	DHHA1 domain	-	-	-	ko:K07463	-	-	-	-	ko00000	-	-	-	DHH,DHHA1
MMS3_k127_63555_1	304371.MCP_0711	3.149e-154	521.0	COG0188@1|root,arCOG04367@2157|Archaea,2XTZV@28890|Euryarchaeota,2N95T@224756|Methanomicrobia	224756|Methanomicrobia	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
MMS3_k127_652939_5	192952.MM_0602	1.541e-29	127.0	COG0533@1|root,arCOG01183@2157|Archaea,arCOG01185@2157|Archaea,2XT07@28890|Euryarchaeota,2N9B7@224756|Methanomicrobia	224756|Methanomicrobia	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function	-	-	2.3.1.234,2.7.11.1	ko:K15904	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko01001,ko03016	-	-	-	Kdo,Peptidase_M22,RIO1
MMS3_k127_652939_3	673860.AciM339_0004	2.362e-74	259.0	COG0010@1|root,arCOG01700@2157|Archaea,2XTEP@28890|Euryarchaeota,3F2M6@33867|unclassified Euryarchaeota	28890|Euryarchaeota	E	Arginase family	speB	GO:0003674,GO:0003824,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0008783,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0016787,GO:0016810,GO:0016813,GO:0034641,GO:0042401,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576	3.5.3.1,3.5.3.11	ko:K01476,ko:K01480	ko00220,ko00330,ko01100,ko01110,ko01130,ko01230,ko05146,map00220,map00330,map01100,map01110,map01130,map01230,map05146	M00029,M00133,M00134	R00551,R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
MMS3_k127_652939_6	985665.HPL003_02075	1.466e-09	70.0	COG0477@1|root,COG2814@2|Bacteria,1TS6K@1239|Firmicutes,4HB1V@91061|Bacilli,26RFG@186822|Paenibacillaceae	91061|Bacilli	EGP	Permeases of the major facilitator superfamily	blt9	-	-	ko:K08153	-	M00717	-	-	ko00000,ko00002,ko02000	2.A.1.2.8	-	-	MFS_1,MFS_1_like,MFS_2,Sugar_tr
MMS3_k127_652939_4	278963.ATWD01000001_gene1850	2.451e-56	207.0	COG1024@1|root,COG1024@2|Bacteria,3Y47B@57723|Acidobacteria,2JIRS@204432|Acidobacteriia	204432|Acidobacteriia	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	-	ECH_1
MMS3_k127_652939_2	1385514.N782_08915	5.149e-98	344.0	COG1960@1|root,COG1960@2|Bacteria,1TP57@1239|Firmicutes,4HA2A@91061|Bacilli,2Y8Z1@289201|Pontibacillus	91061|Bacilli	I	Acyl-CoA dehydrogenase	mmgC	-	-	ko:K18244	-	-	-	-	ko00000,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
MMS3_k127_652939_0	1121430.JMLG01000007_gene2533	7.854e-164	535.0	COG0318@1|root,COG0318@2|Bacteria,1TPSX@1239|Firmicutes,248JC@186801|Clostridia,260H6@186807|Peptococcaceae	186801|Clostridia	IQ	Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
MMS3_k127_652939_7	751944.HALDL1_07550	2.286e-06	60.0	COG1545@1|root,arCOG01286@2157|Archaea,2XZ8D@28890|Euryarchaeota,23WPC@183963|Halobacteria	183963|Halobacteria	S	nucleic-acid-binding protein containing a Zn-ribbon	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
MMS3_k127_652939_1	436308.Nmar_1631	8.608e-108	363.0	COG0183@1|root,arCOG01278@2157|Archaea,41SCI@651137|Thaumarchaeota	651137|Thaumarchaeota	I	Thiolase, N-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
MMS3_k127_658514_1	1183438.GKIL_4247	3.015e-100	332.0	COG3387@1|root,COG3387@2|Bacteria,1G3RH@1117|Cyanobacteria	1117|Cyanobacteria	G	Glucodextranase, domain N	-	-	3.2.1.3	ko:K01178	ko00500,ko01100,map00500,map01100	-	R01790,R01791,R06199	-	ko00000,ko00001,ko01000	-	GH15	-	Glucodextran_N,Glyco_hydro_15
MMS3_k127_658514_3	1459636.NTE_01035	8.533e-70	248.0	COG0640@1|root,COG1809@1|root,arCOG00394@2157|Archaea,arCOG04896@2157|Archaea	2157|Archaea	K	PFAM (2R)-phospho-3-sulfolactate synthase ComA	comA	GO:0003674,GO:0003824,GO:0016829,GO:0016830,GO:0016831,GO:0050545	4.4.1.19	ko:K08097	ko00680,ko01120,map00680,map01120	M00358	R07476	RC01799	ko00000,ko00001,ko00002,ko01000	-	-	-	ComA
MMS3_k127_658514_0	589924.Ferp_2430	1.385e-129	428.0	COG3379@1|root,arCOG01377@2157|Archaea,2XU9G@28890|Euryarchaeota,245NN@183980|Archaeoglobi	183980|Archaeoglobi	S	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
MMS3_k127_658514_8	1229172.JQFA01000004_gene702	2.653e-29	126.0	COG1670@1|root,COG1670@2|Bacteria,1GA76@1117|Cyanobacteria,1HGA7@1150|Oscillatoriales	1117|Cyanobacteria	J	Acetyltransferase (GNAT) domain	-	-	2.3.1.128	ko:K03790	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_3
MMS3_k127_658514_2	1366050.N234_02770	1.194e-89	306.0	COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,2VHR7@28216|Betaproteobacteria,1JZZF@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
MMS3_k127_658514_16	521098.Aaci_1428	0.0004847	50.0	COG0346@1|root,COG0346@2|Bacteria,1V7GY@1239|Firmicutes,4HIYA@91061|Bacilli,27A0T@186823|Alicyclobacillaceae	91061|Bacilli	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	ywbC	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase,Glyoxalase_4
MMS3_k127_658514_4	1128427.KB904821_gene256	7.228e-52	192.0	COG0529@1|root,COG0529@2|Bacteria,1G21C@1117|Cyanobacteria,1H93G@1150|Oscillatoriales	1117|Cyanobacteria	F	Catalyzes the synthesis of activated sulfate	cysC	-	2.7.1.25	ko:K00860	ko00230,ko00920,ko01100,ko01120,map00230,map00920,map01100,map01120	M00176	R00509,R04928	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase
MMS3_k127_658514_9	1047013.AQSP01000122_gene2224	4.765e-25	119.0	COG3291@1|root,COG5434@1|root,COG3291@2|Bacteria,COG5434@2|Bacteria,2NQ6Y@2323|unclassified Bacteria	2|Bacteria	M	PKD domain	-	-	3.2.1.157,3.2.1.91	ko:K19668,ko:K20850	ko00500,ko01100,ko02020,map00500,map01100,map02020	-	R02886,R11308	RC00799	ko00000,ko00001,ko01000	-	GH6,GH82	-	Beta_helix,CHU_C,Cadherin-like,FlgD_ig,PKD,Pectate_lyase_3
MMS3_k127_658514_7	1184251.TCELL_1397	7.268e-32	141.0	COG0463@1|root,arCOG00894@2157|Archaea,2XPZS@28889|Crenarchaeota	28889|Crenarchaeota	M	PFAM Glycosyl transferase family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
MMS3_k127_658514_12	1122917.KB899679_gene482	2.684e-12	79.0	COG2244@1|root,COG2244@2|Bacteria,1TNYX@1239|Firmicutes,4HACG@91061|Bacilli,26QTK@186822|Paenibacillaceae	91061|Bacilli	S	Membrane protein involved in the export of O-antigen and teichoic acid	yabM	-	-	ko:K03328,ko:K06409	-	-	-	-	ko00000,ko02000	2.A.66.2,2.A.66.2.14	-	-	Polysacc_synt,Polysacc_synt_C
MMS3_k127_658514_10	411473.RUMCAL_01785	7.615e-22	108.0	COG0438@1|root,COG0438@2|Bacteria,1V2NV@1239|Firmicutes,25ERN@186801|Clostridia,3WHXX@541000|Ruminococcaceae	186801|Clostridia	M	Glycosyl transferase 4-like domain	-	-	2.4.1.348	ko:K06338,ko:K12995	-	-	-	-	ko00000,ko01000,ko01003,ko01005	-	GT4	-	Glyco_transf_4,Glycos_transf_1
MMS3_k127_658514_15	1283300.ATXB01000001_gene163	0.0001349	53.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,1RPXX@1236|Gammaproteobacteria,1XDMM@135618|Methylococcales	135618|Methylococcales	C	CoA binding domain	-	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_1,CoA_binding_2,Succ_CoA_lig
MMS3_k127_658514_5	1041930.Mtc_0627	1.959e-46	183.0	COG0451@1|root,arCOG01372@2157|Archaea,2Y3R7@28890|Euryarchaeota,2NAUM@224756|Methanomicrobia	224756|Methanomicrobia	M	NAD(P)H-binding	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
MMS3_k127_658514_11	797210.Halxa_3575	4.811e-18	100.0	COG3119@1|root,arCOG02785@2157|Archaea,2Y8G5@28890|Euryarchaeota,241AK@183963|Halobacteria	183963|Halobacteria	P	COG3119 Arylsulfatase A and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
MMS3_k127_658514_6	1132509.C447_02567	6.093e-46	186.0	COG3119@1|root,arCOG02785@2157|Archaea,2Y8G5@28890|Euryarchaeota,241AK@183963|Halobacteria	183963|Halobacteria	P	COG3119 Arylsulfatase A and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
MMS3_k127_658514_14	1122605.KB893626_gene2451	3.434e-05	55.0	COG4099@1|root,COG4099@2|Bacteria,4NFSH@976|Bacteroidetes,1IR5D@117747|Sphingobacteriia	976|Bacteroidetes	S	Phospholipase/Carboxylesterase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_2,Esterase,Peptidase_S9
MMS3_k127_658514_13	1089544.KB912942_gene555	4.788e-06	57.0	COG0454@1|root,COG1042@1|root,COG0456@2|Bacteria,COG1042@2|Bacteria,2GKN1@201174|Actinobacteria,4DYY0@85010|Pseudonocardiales	201174|Actinobacteria	CK	Acyl-CoA synthetase (NDP forming)	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
MMS3_k127_73999_7	479434.Sthe_1776	1.482e-48	194.0	COG0577@1|root,COG3127@1|root,COG0577@2|Bacteria,COG3127@2|Bacteria,2G6CK@200795|Chloroflexi,27Z42@189775|Thermomicrobia	189775|Thermomicrobia	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
MMS3_k127_73999_4	479434.Sthe_1775	1.779e-78	270.0	COG1136@1|root,COG1136@2|Bacteria,2G6B5@200795|Chloroflexi,27YCE@189775|Thermomicrobia	189775|Thermomicrobia	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
MMS3_k127_73999_10	1463825.JNXC01000031_gene1610	3.734e-32	142.0	COG0477@1|root,COG2814@2|Bacteria,2GM0Q@201174|Actinobacteria,4E98P@85010|Pseudonocardiales	201174|Actinobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
MMS3_k127_73999_6	460265.Mnod_2730	3.837e-52	193.0	COG4106@1|root,COG4106@2|Bacteria,1QWJU@1224|Proteobacteria,2TWZZ@28211|Alphaproteobacteria,1JX8V@119045|Methylobacteriaceae	28211|Alphaproteobacteria	H	Thiopurine S-methyltransferase (TPMT)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
MMS3_k127_73999_11	273063.STK_17710	2.431e-27	126.0	COG0842@1|root,arCOG01467@2157|Archaea,2XQF4@28889|Crenarchaeota	28889|Crenarchaeota	V	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
MMS3_k127_73999_1	985053.VMUT_1291	9.975e-94	319.0	COG1131@1|root,arCOG00194@2157|Archaea,2XPVP@28889|Crenarchaeota	28889|Crenarchaeota	V	TIGRFAM daunorubicin resistance ABC transporter ATPase subunit	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
MMS3_k127_73999_15	192952.MM_2470	7.351e-12	79.0	COG1520@1|root,COG3291@1|root,COG3391@1|root,arCOG02516@1|root,arCOG02550@1|root,arCOG02482@2157|Archaea,arCOG02508@2157|Archaea,arCOG02516@2157|Archaea,arCOG02550@2157|Archaea,arCOG02562@2157|Archaea	2157|Archaea	Q	40-residue YVTN family beta-propeller	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase,NosD,PKD,PQQ_2,PQQ_3,Pkinase
MMS3_k127_73999_3	469371.Tbis_2726	2.035e-81	278.0	COG0412@1|root,COG0412@2|Bacteria,2I151@201174|Actinobacteria,4E3BE@85010|Pseudonocardiales	201174|Actinobacteria	Q	Dienelactone hydrolase family	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
MMS3_k127_73999_5	649831.L083_4644	1.018e-59	221.0	COG0596@1|root,COG0596@2|Bacteria,2IFCI@201174|Actinobacteria,4DC31@85008|Micromonosporales	201174|Actinobacteria	S	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
MMS3_k127_73999_0	251221.35213411	3.224e-122	400.0	COG0667@1|root,COG0667@2|Bacteria,1G2QT@1117|Cyanobacteria	1117|Cyanobacteria	C	aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
MMS3_k127_73999_12	868131.MSWAN_0985	2.133e-16	87.0	COG2329@1|root,arCOG05403@2157|Archaea,2Y22C@28890|Euryarchaeota	28890|Euryarchaeota	S	Chlorite dismutase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
MMS3_k127_73999_9	1284352.AOIG01000013_gene3550	3.989e-36	159.0	COG0457@1|root,COG3210@1|root,COG5492@1|root,COG0457@2|Bacteria,COG3210@2|Bacteria,COG5492@2|Bacteria,1TR9M@1239|Firmicutes,4HEPP@91061|Bacilli,26T62@186822|Paenibacillaceae	91061|Bacilli	U	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,Cadherin-like,Cohesin,Invasin_D3,SLH
MMS3_k127_73999_8	1047013.AQSP01000122_gene2223	1.032e-47	196.0	COG3291@1|root,COG3291@2|Bacteria,2NQ6Y@2323|unclassified Bacteria	2|Bacteria	M	PKD domain	-	-	3.2.1.91	ko:K19668	ko00500,ko01100,ko02020,map00500,map01100,map02020	-	R02886,R11308	RC00799	ko00000,ko00001,ko01000	-	GH6	-	CBM_2,CHU_C,FlgD_ig,Glyco_hydro_6,PKD,VCBS
MMS3_k127_73999_16	268739.Nmlp_2650	2.54e-08	68.0	COG1361@1|root,COG1470@1|root,COG3291@1|root,arCOG03612@1|root,arCOG04500@1|root,arCOG07554@1|root,arCOG02081@2157|Archaea,arCOG02089@2157|Archaea,arCOG02510@2157|Archaea,arCOG03612@2157|Archaea,arCOG04500@2157|Archaea,arCOG07554@2157|Archaea,2XWGB@28890|Euryarchaeota,23UX2@183963|Halobacteria	183963|Halobacteria	M	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_73999_13	374847.Kcr_0680	2.413e-13	85.0	arCOG02499@1|root,arCOG02499@2157|Archaea	2157|Archaea	S	Periplasmic copper-binding protein (NosD)	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,CHB_HEX_C_1,NosD
MMS3_k127_73999_14	1056495.Calag_1003	4.182e-13	84.0	COG3391@1|root,arCOG06052@1|root,arCOG02560@2157|Archaea,arCOG06052@2157|Archaea,2XRYP@28889|Crenarchaeota	28889|Crenarchaeota	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_73999_2	1057002.KB905370_gene1489	7.395e-92	327.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,4B9BA@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Adenylate cyclase	cyaF	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,TPR_16,TPR_19,TPR_2,TPR_8
MMS3_k127_743604_5	1267535.KB906767_gene4758	8.321e-59	220.0	COG0365@1|root,COG0365@2|Bacteria,3Y39K@57723|Acidobacteria,2JI3Z@204432|Acidobacteriia	204432|Acidobacteriia	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
MMS3_k127_743604_7	443143.GM18_2087	3.473e-49	187.0	COG1545@1|root,COG1545@2|Bacteria,1NPAR@1224|Proteobacteria,42WW8@68525|delta/epsilon subdivisions,2WSYD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Rubredoxin-like zinc ribbon domain (DUF35_N)	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
MMS3_k127_743604_1	443143.GM18_2086	1.482e-180	576.0	COG0183@1|root,COG0183@2|Bacteria,1MU8C@1224|Proteobacteria,42N6X@68525|delta/epsilon subdivisions,2WJIE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
MMS3_k127_743604_3	439481.Aboo_0158	1.282e-98	353.0	COG0448@1|root,arCOG00912@2157|Archaea,2XTI4@28890|Euryarchaeota,3F2GM@33867|unclassified Euryarchaeota	28890|Euryarchaeota	E	aspartate ornithine carbamoyltransferase carbamoyl-P binding domain	argF	GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
MMS3_k127_743604_15	1220534.B655_2136	6.123e-19	94.0	COG1813@1|root,arCOG01863@2157|Archaea,2XXND@28890|Euryarchaeota,23PPT@183925|Methanobacteria	183925|Methanobacteria	K	Helix-turn-helix XRE-family like proteins	-	-	-	ko:K03627	-	-	-	-	ko00000	-	-	-	HTH_3
MMS3_k127_743604_12	1379270.AUXF01000001_gene2675	6.604e-34	136.0	COG1607@1|root,COG1607@2|Bacteria,1ZTQ1@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
MMS3_k127_743604_0	368407.Memar_0730	1.177e-193	614.0	COG5256@1|root,arCOG01561@2157|Archaea,2XTNM@28890|Euryarchaeota,2N9FZ@224756|Methanomicrobia	224756|Methanomicrobia	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03231	ko03013,ko05134,map03013,map05134	-	-	-	ko00000,ko00001,ko03012,ko03016,ko03019,ko04131,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
MMS3_k127_743604_11	1054217.TALC_00390	3.288e-38	160.0	COG0051@1|root,arCOG01758@2157|Archaea,2XXV8@28890|Euryarchaeota,241R0@183967|Thermoplasmata	183967|Thermoplasmata	J	Involved in the binding of tRNA to the ribosomes	rps10	-	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
MMS3_k127_743604_13	469382.Hbor_00020	4.447e-31	130.0	COG0688@1|root,arCOG04470@2157|Archaea,2XX5J@28890|Euryarchaeota,23TM1@183963|Halobacteria	183963|Halobacteria	I	phosphatidylserine decarboxylase	psd	-	4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PS_Dcarbxylase
MMS3_k127_743604_19	1246995.AFR_05000	2.647e-07	61.0	COG1183@1|root,COG1183@2|Bacteria,2I3MV@201174|Actinobacteria,4DA88@85008|Micromonosporales	201174|Actinobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pssA	GO:0003674,GO:0003824,GO:0003882,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0071944,GO:0090407,GO:1901576	2.7.8.8	ko:K17103	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	M00093	R01800	RC00002,RC00017,RC02795	ko00000,ko00001,ko00002,ko01000	-	-	-	CDP-OH_P_tran_2,CDP-OH_P_transf
MMS3_k127_743604_16	368407.Memar_1241	2.256e-14	87.0	COG2098@1|root,arCOG04705@2157|Archaea,2XY43@28890|Euryarchaeota	28890|Euryarchaeota	S	Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD)	mptD	-	4.1.2.25	ko:K09739	ko00790,map00790	-	R03504	RC00721,RC00943	ko00000,ko00001,ko01000	-	-	-	DHNA
MMS3_k127_743604_2	1051632.TPY_1127	5.541e-114	399.0	COG0372@1|root,COG0372@2|Bacteria,1TPPS@1239|Firmicutes,24865@186801|Clostridia,3WD3X@538999|Clostridiales incertae sedis	186801|Clostridia	C	Citrate synthase, C-terminal domain	gltA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
MMS3_k127_743604_18	1042877.GQS_04300	6.423e-08	65.0	COG0477@1|root,arCOG00131@2157|Archaea,2XUXU@28890|Euryarchaeota,242UP@183968|Thermococci	183968|Thermococci	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS3_k127_743604_14	673860.AciM339_0553	5.867e-31	123.0	COG1522@1|root,arCOG01117@2157|Archaea,2XZY2@28890|Euryarchaeota,3F3G3@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	Lrp/AsnC ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
MMS3_k127_743604_17	263820.PTO0515	1.294e-08	60.0	arCOG07411@1|root,arCOG07411@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_743604_8	215803.DB30_5543	2.252e-46	178.0	COG1912@1|root,COG1912@2|Bacteria,1MV99@1224|Proteobacteria,42SHG@68525|delta/epsilon subdivisions,2WP1D@28221|Deltaproteobacteria,2YWS7@29|Myxococcales	28221|Deltaproteobacteria	S	S-adenosyl-l-methionine hydroxide adenosyltransferase	-	-	-	ko:K22205	-	-	-	-	ko00000,ko01000	-	-	-	SAM_adeno_trans
MMS3_k127_743604_4	457570.Nther_1184	4.427e-96	332.0	COG0484@1|root,COG0484@2|Bacteria,1TP00@1239|Firmicutes,248EM@186801|Clostridia	186801|Clostridia	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686,ko:K05516	-	-	-	-	ko00000,ko03029,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
MMS3_k127_743604_9	1042877.GQS_04725	1.394e-44	170.0	COG2126@1|root,arCOG00110@2157|Archaea,2XUYG@28890|Euryarchaeota,243FR@183968|Thermococci	183968|Thermococci	Q	tRNA (Uracil-5-)-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	MTS
MMS3_k127_743604_10	351160.RCIX2580	1.569e-39	156.0	COG0099@1|root,arCOG01722@2157|Archaea,2XWHE@28890|Euryarchaeota,2N9RA@224756|Methanomicrobia	224756|Methanomicrobia	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rps13	-	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
MMS3_k127_743604_6	673860.AciM339_1559	2.029e-57	208.0	COG0522@1|root,arCOG04239@2157|Archaea,2XXYX@28890|Euryarchaeota,3F2KM@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rps4	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
MMS3_k127_793503_9	1121017.AUFG01000017_gene2498	1.292e-09	65.0	COG4243@1|root,COG4243@2|Bacteria,2HGRN@201174|Actinobacteria,4FGUP@85021|Intrasporangiaceae	201174|Actinobacteria	S	VKc	-	-	-	-	-	-	-	-	-	-	-	-	VKOR
MMS3_k127_793503_8	671065.MetMK1DRAFT_00008720	2.351e-17	94.0	arCOG03842@1|root,arCOG03842@2157|Archaea	2157|Archaea	S	Domain of unknown function (DUF929)	-	-	-	-	-	-	-	-	-	-	-	-	DUF929
MMS3_k127_793503_4	673860.AciM339_1083	3.287e-77	269.0	COG1234@1|root,arCOG00501@2157|Archaea,2XTJ9@28890|Euryarchaeota,3F2KC@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA	rnz	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0031123,GO:0034414,GO:0034470,GO:0034641,GO:0034660,GO:0042779,GO:0042780,GO:0042781,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1905267	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
MMS3_k127_793503_1	1121468.AUBR01000045_gene1802	8.311e-95	331.0	COG1228@1|root,COG1228@2|Bacteria,1TP2J@1239|Firmicutes,24AGR@186801|Clostridia,42EXG@68295|Thermoanaerobacterales	186801|Clostridia	F	Belongs to the metallo-dependent hydrolases superfamily. HutI family	hutI	-	3.5.2.7	ko:K01468	ko00340,ko01100,map00340,map01100	M00045	R02288	RC00683	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
MMS3_k127_793503_6	593750.Metfor_2881	1.038e-25	108.0	arCOG12677@1|root,arCOG12677@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_793503_0	404589.Anae109_2198	8.891e-296	934.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,42N8M@68525|delta/epsilon subdivisions,2WJRT@28221|Deltaproteobacteria,2YUBZ@29|Myxococcales	28221|Deltaproteobacteria	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdA1	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_2_N,Ribonuc_red_lgC
MMS3_k127_793503_3	273063.STK_09740	1.369e-81	289.0	COG0438@1|root,arCOG01408@2157|Archaea	2157|Archaea	M	Glycosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glycos_transf_1
MMS3_k127_793503_10	1184251.TCELL_1282	0.0003204	54.0	COG1011@1|root,arCOG02291@2157|Archaea,2XQJE@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM Haloacid dehalogenase domain protein hydrolase	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
MMS3_k127_793503_5	290397.Adeh_2557	6.024e-37	159.0	COG0177@1|root,COG0177@2|Bacteria,1RAK3@1224|Proteobacteria,42M4V@68525|delta/epsilon subdivisions,2WPRX@28221|Deltaproteobacteria,2YW8E@29|Myxococcales	28221|Deltaproteobacteria	L	Protein of unknown function (DUF2400)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2400
MMS3_k127_793503_7	397948.Cmaq_1948	9.794e-19	96.0	arCOG00828@1|root,arCOG00828@2157|Archaea,2XS6C@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	FR47
MMS3_k127_793503_2	670487.Ocepr_1681	1.775e-89	328.0	COG1387@1|root,COG1796@1|root,COG1387@2|Bacteria,COG1796@2|Bacteria,1WII0@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	L	PFAM PHP domain	-	-	-	ko:K02347	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_thumb,HHH_5,HHH_8,PHP
MMS3_k127_800873_2	525909.Afer_1461	1.23e-34	152.0	COG0177@1|root,COG0177@2|Bacteria,2GJ01@201174|Actinobacteria,4CN7C@84992|Acidimicrobiia	84992|Acidimicrobiia	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
MMS3_k127_800873_1	240015.ACP_2169	4.833e-70	255.0	COG0285@1|root,COG0285@2|Bacteria,3Y3ZA@57723|Acidobacteria,2JI7I@204432|Acidobacteriia	204432|Acidobacteriia	H	PFAM Mur ligase	-	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M
MMS3_k127_800873_0	357808.RoseRS_0214	1.223e-134	437.0	COG1884@1|root,COG1884@2|Bacteria,2G62T@200795|Chloroflexi,374XE@32061|Chloroflexia	32061|Chloroflexia	I	TIGRFAM methylmalonyl-CoA mutase, large subunit	-	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
MMS3_k127_808863_0	880072.Desac_0647	6.066e-52	198.0	COG0128@1|root,COG0128@2|Bacteria,1MWMK@1224|Proteobacteria,42N01@68525|delta/epsilon subdivisions,2WKJQ@28221|Deltaproteobacteria,2MQGI@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
MMS3_k127_808863_5	362976.HQ_2762A	1.637e-20	108.0	COG1685@1|root,arCOG01025@2157|Archaea,2XUI2@28890|Euryarchaeota,23RZX@183963|Halobacteria	183963|Halobacteria	E	Shikimate kinase	aroK	-	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_N
MMS3_k127_808863_4	1122180.Lokhon_00693	3.508e-27	130.0	COG0169@1|root,COG0169@2|Bacteria,1MVH4@1224|Proteobacteria,2TS99@28211|Alphaproteobacteria,2P7XJ@245186|Loktanella	28211|Alphaproteobacteria	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	-	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_DH,Shikimate_dh_N
MMS3_k127_808863_3	1041930.Mtc_1382	2.46e-40	169.0	COG1465@1|root,arCOG04353@2157|Archaea,2XSXD@28890|Euryarchaeota,2N9AV@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis	aroB'	-	1.4.1.24	ko:K11646	ko00400,ko01110,ko01130,map00400,map01110,map01130	-	R08569	RC02302	ko00000,ko00001,ko01000	-	-	-	DHQS
MMS3_k127_808863_1	55952.BU52_00915	2.333e-48	183.0	COG1830@1|root,COG1830@2|Bacteria,2IB09@201174|Actinobacteria	201174|Actinobacteria	G	Aldolase	griI	-	2.3.1.245,4.1.2.13,4.1.2.56	ko:K08321,ko:K11645,ko:K18287	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko02024,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map02024	M00001,M00003	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	DeoC
MMS3_k127_808863_6	1303518.CCALI_01929	4.185e-17	91.0	COG5424@1|root,COG5424@2|Bacteria	2|Bacteria	H	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ	CP_1111	GO:0005575,GO:0005576	1.3.3.11	ko:K06137	-	-	-	-	ko00000,ko01000	-	-	-	Haem_oxygenas_2,TENA_THI-4
MMS3_k127_808863_2	138119.DSY3799	2.909e-46	175.0	COG1804@1|root,COG1804@2|Bacteria,1TP54@1239|Firmicutes,24AFN@186801|Clostridia,264EW@186807|Peptococcaceae	2|Bacteria	C	acyl-CoA transferase	-	-	2.8.3.21	ko:K08298	-	-	R10643,R10644	RC00014,RC00131	ko00000,ko01000	-	-	-	CoA_transf_3
MMS3_k127_865704_1	937777.Deipe_2927	1.02e-12	75.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
MMS3_k127_865704_0	1265490.JHVY01000010_gene2858	8.621e-13	80.0	COG0477@1|root,COG2814@2|Bacteria,1MVQQ@1224|Proteobacteria,1RNR4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	EGP	Major facilitator superfamily	-	-	-	ko:K08195	-	-	-	-	ko00000,ko02000	2.A.1.15	-	-	MFS_1,Sugar_tr
MMS3_k127_866091_0	760568.Desku_1330	6.569e-180	591.0	COG0249@1|root,COG0249@2|Bacteria,1TPRJ@1239|Firmicutes,248GI@186801|Clostridia,260PA@186807|Peptococcaceae	186801|Clostridia	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
MMS3_k127_900190_3	1380394.JADL01000007_gene4621	0.0006281	49.0	COG2227@1|root,COG2227@2|Bacteria,1NKIZ@1224|Proteobacteria,2UKY6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
MMS3_k127_900190_1	663321.REG_1813	5.988e-19	99.0	COG0438@1|root,COG0438@2|Bacteria,1N9EV@1224|Proteobacteria,1RYRV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	glycosyl transferase group 1	wbpY	-	2.4.1.349	ko:K12994	-	-	-	-	ko00000,ko01000,ko01003,ko01005	-	GT4	-	Glyco_transf_4,Glycos_transf_1
MMS3_k127_900190_0	330779.Saci_1920	2.55e-27	128.0	COG3463@1|root,arCOG03812@2157|Archaea	2157|Archaea	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF2079
MMS3_k127_900190_2	671065.MetMK1DRAFT_00033810	1.058e-15	87.0	COG0463@1|root,arCOG01397@2157|Archaea,2XQXI@28889|Crenarchaeota	28889|Crenarchaeota	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
MMS3_k127_903657_1	1121866.AUGK01000014_gene2122	3.853e-05	52.0	2DPVJ@1|root,333JK@2|Bacteria,2HCIW@201174|Actinobacteria,4CW3S@84998|Coriobacteriia	84998|Coriobacteriia	S	Double zinc ribbon	-	-	-	-	-	-	-	-	-	-	-	-	DZR,zinc_ribbon_2
MMS3_k127_903657_0	1041930.Mtc_1305	1.777e-116	389.0	COG1602@1|root,arCOG04269@2157|Archaea,2XTEQ@28890|Euryarchaeota,2NADJ@224756|Methanomicrobia	224756|Methanomicrobia	S	Pfam:DUF650	-	-	-	-	-	-	-	-	-	-	-	-	Nre_C,Nre_N
MMS3_k127_912292_6	479434.Sthe_2326	2.056e-29	124.0	COG0276@1|root,COG0276@2|Bacteria,2G6A2@200795|Chloroflexi,27XJN@189775|Thermomicrobia	189775|Thermomicrobia	H	Catalyzes the ferrous insertion into protoporphyrin IX	hemH	-	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	Ferrochelatase
MMS3_k127_912292_3	273116.14324374	2.144e-33	135.0	COG5615@1|root,arCOG05392@2157|Archaea,2Y453@28890|Euryarchaeota,2429S@183967|Thermoplasmata	183967|Thermoplasmata	S	protein, homolog of Cu resistance protein CopC	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_912292_1	196162.Noca_1430	6.909e-109	381.0	COG0535@1|root,COG0535@2|Bacteria,2GNSY@201174|Actinobacteria,4DNSX@85009|Propionibacteriales	201174|Actinobacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM,SPASM
MMS3_k127_912292_5	397948.Cmaq_1265	6.429e-30	136.0	arCOG06964@1|root,arCOG06964@2157|Archaea,2XRZS@28889|Crenarchaeota	28889|Crenarchaeota	E	Peptidase A4 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_A4
MMS3_k127_912292_0	1006006.Mcup_1452	5.348e-136	465.0	COG0308@1|root,arCOG02969@2157|Archaea,2XRK6@28889|Crenarchaeota	28889|Crenarchaeota	E	peptide catabolic process	ape2	-	-	ko:K13722	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	ERAP1_C,Peptidase_M1
MMS3_k127_912292_4	1236689.MMALV_13930	8.478e-33	138.0	COG1650@1|root,arCOG01616@2157|Archaea,2XUM0@28890|Euryarchaeota,3F2M2@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo	dtdA	-	3.1.1.96	ko:K09716	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_deacylase
MMS3_k127_912292_2	1382356.JQMP01000001_gene1193	8.996e-58	218.0	COG0612@1|root,COG0612@2|Bacteria,2G5N3@200795|Chloroflexi,27XVK@189775|Thermomicrobia	189775|Thermomicrobia	S	Insulinase (Peptidase family M16)	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
MMS3_k127_912315_0	399549.Msed_0575	4.531e-137	474.0	COG0308@1|root,arCOG02969@2157|Archaea,2XRK6@28889|Crenarchaeota	28889|Crenarchaeota	E	peptide catabolic process	ape2	-	-	ko:K13722	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	ERAP1_C,Peptidase_M1
MMS3_k127_912315_4	1071085.KK033114_gene839	3.182e-06	61.0	COG0589@1|root,arCOG02053@2157|Archaea,2XY1H@28890|Euryarchaeota,23W7S@183963|Halobacteria	183963|Halobacteria	T	COG0589 Universal stress protein UspA and related nucleotide-binding proteins	usp26	-	-	-	-	-	-	-	-	-	-	-	Usp
MMS3_k127_912315_1	1229909.NSED_09015	1.338e-37	160.0	COG1269@1|root,arCOG04138@2157|Archaea,41SRH@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Belongs to the V-ATPase 116 kDa subunit family	-	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
MMS3_k127_912315_2	926569.ANT_10990	1.162e-16	90.0	COG0664@1|root,COG0664@2|Bacteria,2G92E@200795|Chloroflexi	200795|Chloroflexi	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
MMS3_k127_912315_3	251221.35211040	3.413e-12	77.0	COG2114@1|root,COG2114@2|Bacteria	2|Bacteria	T	Pfam Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc
MMS3_k127_925150_8	760117.JN27_05450	7.119e-05	53.0	COG0467@1|root,COG0467@2|Bacteria,1NEWW@1224|Proteobacteria,2VIKV@28216|Betaproteobacteria,474P3@75682|Oxalobacteraceae	28216|Betaproteobacteria	T	KaiC	-	-	-	ko:K08482	-	-	-	-	ko00000	-	-	-	ATPase
MMS3_k127_925150_1	1177154.Y5S_02709	3.997e-121	405.0	COG0027@1|root,COG0027@2|Bacteria,1N3KA@1224|Proteobacteria,1RNTW@1236|Gammaproteobacteria,1XHPS@135619|Oceanospirillales	135619|Oceanospirillales	F	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate	purT	-	2.1.2.2	ko:K08289	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp,Epimerase
MMS3_k127_925150_7	439481.Aboo_0321	1.255e-08	62.0	arCOG13506@1|root,arCOG13506@2157|Archaea,2Y76D@28890|Euryarchaeota,3F3GT@33867|unclassified Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_925150_5	529709.PYCH_13930	6.156e-50	189.0	COG0149@1|root,arCOG01087@2157|Archaea,2XTY3@28890|Euryarchaeota,24332@183968|Thermococci	183968|Thermococci	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM,ThiG
MMS3_k127_925150_4	56780.SYN_00881	1.524e-61	230.0	COG0297@1|root,COG0297@2|Bacteria,1R6U0@1224|Proteobacteria,42Q1W@68525|delta/epsilon subdivisions,2WJXW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Starch synthase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glyco_transf_5,Glycos_transf_1
MMS3_k127_925150_3	1237149.C900_03394	1.648e-96	347.0	COG1449@1|root,COG1449@2|Bacteria,4NFXW@976|Bacteroidetes,47P2J@768503|Cytophagia	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 57 family	amyA	-	3.2.1.1	ko:K07405	ko00500,ko01100,map00500,map01100	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH57	-	Glyco_hydro_57
MMS3_k127_925150_6	358396.C445_20202	9.415e-10	69.0	arCOG02274@1|root,arCOG02274@2157|Archaea,2XX6V@28890|Euryarchaeota,23VXE@183963|Halobacteria	183963|Halobacteria	K	Bacterio-opsin activator HTH domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_10
MMS3_k127_925150_2	304371.MCP_0007	1.979e-114	393.0	COG3387@1|root,arCOG03285@2157|Archaea,2XUZ8@28890|Euryarchaeota,2NAP9@224756|Methanomicrobia	224756|Methanomicrobia	G	COG3387 Glucoamylase and related glycosyl hydrolases	-	-	-	-	-	-	-	-	-	-	-	iAF692.Mbar_A1916	Glyco_hydro_15
MMS3_k127_925150_0	1173023.KE650771_gene1915	4.876e-201	639.0	COG3387@1|root,COG3387@2|Bacteria,1G3RH@1117|Cyanobacteria,1JKJ5@1189|Stigonemataceae	1117|Cyanobacteria	G	Glucodextranase, domain N	-	-	3.2.1.3	ko:K01178	ko00500,ko01100,map00500,map01100	-	R01790,R01791,R06199	-	ko00000,ko00001,ko01000	-	GH15	-	Glucodextran_N,Glyco_hydro_15
MMS3_k127_930091_9	266117.Rxyl_3070	3.706e-15	81.0	COG0589@1|root,COG0589@2|Bacteria,2GSJK@201174|Actinobacteria,4CQXK@84995|Rubrobacteria	201174|Actinobacteria	T	COG COG0589 Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms	uspA2	-	-	-	-	-	-	-	-	-	-	-	Usp
MMS3_k127_930091_5	589924.Ferp_0918	1.398e-49	186.0	COG0197@1|root,arCOG04113@2157|Archaea,2XTHT@28890|Euryarchaeota,246TI@183980|Archaeoglobi	183980|Archaeoglobi	J	Belongs to the universal ribosomal protein uL16 family	rpl10e	-	-	ko:K02866	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
MMS3_k127_930091_8	1054217.TALC_00145	6.718e-29	128.0	COG1829@1|root,arCOG04263@2157|Archaea,2XST6@28890|Euryarchaeota	28890|Euryarchaeota	S	kinase, sugar kinase superfamily	coaA	-	2.7.1.169	ko:K06982	ko00770,ko01100,map00770,map01100	-	R09378	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	iAF692.Mbar_A3255	GHMP_kinases_N
MMS3_k127_930091_2	673860.AciM339_1196	4.478e-156	507.0	COG1222@1|root,arCOG01306@2157|Archaea,2XTB6@28890|Euryarchaeota,3F2I3@33867|unclassified Euryarchaeota	28890|Euryarchaeota	O	ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C- terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates	pan	GO:0000502,GO:0003674,GO:0003824,GO:0003924,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0022623,GO:0022624,GO:0030163,GO:0032991,GO:0043170,GO:0043273,GO:0043335,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369	-	ko:K03420	ko03050,map03050	M00343	-	-	ko00000,ko00001,ko00002,ko03051	-	-	-	AAA,Prot_ATP_ID_OB
MMS3_k127_930091_6	1054217.TALC_00985	1.56e-41	166.0	COG3276@1|root,arCOG01564@2157|Archaea,2XWBV@28890|Euryarchaeota,241RR@183967|Thermoplasmata	183967|Thermoplasmata	J	PFAM elongation factor Tu, domain 2 protein	-	-	-	-	-	-	-	-	-	-	-	-	GTP_EFTU_D2
MMS3_k127_930091_0	671143.DAMO_1073	8.632e-306	960.0	COG0542@1|root,COG0542@2|Bacteria,2NNNE@2323|unclassified Bacteria	2|Bacteria	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K03694,ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
MMS3_k127_930091_3	644281.MFS40622_1530	1.562e-74	265.0	COG0167@1|root,arCOG00603@2157|Archaea,2XTMB@28890|Euryarchaeota,23QC5@183939|Methanococci	183939|Methanococci	F	Catalyzes the conversion of dihydroorotate to orotate	pyrD	GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	1.3.1.14	ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
MMS3_k127_930091_4	673860.AciM339_0239	4.171e-56	218.0	COG0543@1|root,arCOG02199@2157|Archaea,2XSY9@28890|Euryarchaeota,3F2KR@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B	pyrK	-	-	ko:K02823	ko00240,ko01100,map00240,map01100	-	-	-	ko00000,ko00001	-	-	-	DHODB_Fe-S_bind,NAD_binding_1
MMS3_k127_930091_1	439481.Aboo_0791	3.219e-205	655.0	COG0504@1|root,arCOG00063@2157|Archaea,2XTR2@28890|Euryarchaeota,3F2HU@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
MMS3_k127_930091_7	673860.AciM339_0578	2.363e-39	164.0	COG0017@1|root,arCOG00406@2157|Archaea,2XTRE@28890|Euryarchaeota,3F2GB@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp)	aspS	-	6.1.1.12,6.1.1.23	ko:K09759,ko:K22503	ko00970,map00970	M00359,M00360	R03647,R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
MMS3_k127_937034_12	1120972.AUMH01000010_gene260	1.629e-15	81.0	COG2963@1|root,COG2963@2|Bacteria,1VPYW@1239|Firmicutes,4HZBX@91061|Bacilli	91061|Bacilli	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_1
MMS3_k127_937034_4	387631.Asulf_01416	5.989e-84	294.0	COG0582@1|root,arCOG01245@2157|Archaea,2Y83V@28890|Euryarchaeota,246UP@183980|Archaeoglobi	183980|Archaeoglobi	L	integrase family	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_937034_10	1054217.TALC_01534	1.672e-16	89.0	COG3388@1|root,arCOG01345@2157|Archaea,2XXVY@28890|Euryarchaeota,241VN@183967|Thermoplasmata	183967|Thermoplasmata	K	protein conserved in archaea	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_937034_14	439481.Aboo_0147	1.176e-06	56.0	COG0640@1|root,arCOG03067@2157|Archaea,2Y747@28890|Euryarchaeota,3F3DB@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
MMS3_k127_937034_15	1448860.BBJO01000014_gene1109	0.0005282	50.0	arCOG03915@1|root,arCOG03915@2157|Archaea,2XZRQ@28890|Euryarchaeota,23XHM@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_937034_5	69014.TK1909	2.594e-51	196.0	COG0463@1|root,arCOG00894@2157|Archaea,2XWXA@28890|Euryarchaeota,242RY@183968|Thermococci	183968|Thermococci	M	GtrA-like protein	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2,GtrA
MMS3_k127_937034_8	479434.Sthe_2499	2.492e-27	120.0	29JD5@1|root,306AN@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_937034_6	1304865.JAGF01000001_gene2445	1.839e-32	139.0	COG0697@1|root,COG0697@2|Bacteria,2IH82@201174|Actinobacteria	201174|Actinobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
MMS3_k127_937034_13	1380386.JIAW01000025_gene6802	4.324e-15	80.0	COG0298@1|root,COG0298@2|Bacteria,2IMSQ@201174|Actinobacteria,239ZW@1762|Mycobacteriaceae	201174|Actinobacteria	O	Hydrogenase assembly chaperone hypC hupF	hypC	-	-	ko:K04653	-	-	-	-	ko00000	-	-	-	HupF_HypC
MMS3_k127_937034_9	469371.Tbis_1857	4.094e-24	119.0	COG0680@1|root,COG0680@2|Bacteria,2IJ3P@201174|Actinobacteria,4E5EF@85010|Pseudonocardiales	201174|Actinobacteria	C	Hydrogenase maturation protease	-	-	-	ko:K03605	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	HycI
MMS3_k127_937034_0	159450.NH14_30350	7.405e-169	553.0	COG3259@1|root,COG3259@2|Bacteria,1QUQ7@1224|Proteobacteria,2VJT0@28216|Betaproteobacteria,1K6S4@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Nickel-dependent hydrogenase	hoxH	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	1.12.1.2	ko:K00436	-	-	R00700	-	ko00000,ko01000	-	-	-	NiFeSe_Hases
MMS3_k127_937034_2	518766.Rmar_2589	4.855e-120	390.0	COG1941@1|root,COG1941@2|Bacteria	2|Bacteria	C	coenzyme F420 hydrogenase activity	hoxY	-	-	-	-	-	-	-	-	-	-	-	Oxidored_q6
MMS3_k127_937034_3	518766.Rmar_2588	1.685e-99	335.0	COG0543@1|root,COG0543@2|Bacteria	2|Bacteria	C	2 iron, 2 sulfur cluster binding	asrB	-	-	ko:K02823	ko00240,ko01100,map00240,map01100	-	-	-	ko00000,ko00001	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
MMS3_k127_937034_7	322710.Avin_04370	1.211e-28	132.0	COG0664@1|root,COG0664@2|Bacteria,1RII7@1224|Proteobacteria,1S7IH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
MMS3_k127_937034_1	518766.Rmar_2586	6.41e-141	457.0	COG0479@1|root,COG0479@2|Bacteria	2|Bacteria	C	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family	asrA	-	-	ko:K16950	ko00920,ko01120,map00920,map01120	-	R00858,R10146	RC00065	ko00000,ko00001	-	-	-	Fer4_22
MMS3_k127_994041_4	273075.Ta1038	4.659e-31	126.0	COG2219@1|root,arCOG03013@2157|Archaea,2XTDT@28890|Euryarchaeota,241UK@183967|Thermoplasmata	183967|Thermoplasmata	L	Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair	priL	-	-	ko:K18882	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_primase_lrg
MMS3_k127_994041_5	673860.AciM339_1340	3.861e-28	128.0	COG0558@1|root,arCOG00670@2157|Archaea,2XWJ0@28890|Euryarchaeota,3F2ME@33867|unclassified Euryarchaeota	28890|Euryarchaeota	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA	-	2.7.8.39,2.7.8.5	ko:K00995,ko:K17884	ko00564,ko01100,map00564,map01100	-	R01801,R10464	RC00002,RC00017,RC00078,RC02795	ko00000,ko00001,ko01000	-	-	iAF692.Mbar_A1250	CDP-OH_P_transf
MMS3_k127_994041_6	351160.RCIX2459	1.277e-17	95.0	COG1936@1|root,arCOG01038@2157|Archaea,2XX2A@28890|Euryarchaeota,2N9V1@224756|Methanomicrobia	224756|Methanomicrobia	F	Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates	-	-	2.7.4.3	ko:K18532	ko00230,ko01100,ko01110,ko01130,ko03008,map00230,map01100,map01110,map01130,map03008	M00049	R00127,R01547	RC00002	ko00000,ko00001,ko00002,ko01000,ko03009	-	-	-	AAA_18
MMS3_k127_994041_0	273116.14325760	7.775e-98	364.0	COG4934@1|root,arCOG03665@2157|Archaea	2157|Archaea	O	tripeptidyl-peptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	CHB_HEX_C_1
MMS3_k127_994041_1	439481.Aboo_0635	5.368e-75	271.0	COG0112@1|root,arCOG00070@2157|Archaea,2XX80@28890|Euryarchaeota,3F334@33867|unclassified Euryarchaeota	28890|Euryarchaeota	E	Serine hydroxymethyltransferase	-	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
MMS3_k127_994041_2	604354.TSIB_0492	5.895e-32	140.0	COG1096@1|root,arCOG00676@2157|Archaea,2XYYA@28890|Euryarchaeota,243T0@183968|Thermococci	183968|Thermococci	J	Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs	csl4	-	-	ko:K07573	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	ECR1_N,EXOSC1
MMS3_k127_994041_3	246969.TAM4_456	8.518e-32	132.0	COG2263@1|root,arCOG00910@2157|Archaea,2XU4P@28890|Euryarchaeota,24393@183968|Thermococci	183968|Thermococci	J	Conserved hypothetical protein 95	-	-	-	ko:K07579	-	-	-	-	ko00000	-	-	-	MTS,PrmA
## 1474 queries scanned
## Total time (seconds): 98.25768399238586
## Rate: 15.00 q/s