## Sat Nov 16 06:57:08 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/bin_4635/bin/bin17/MMS_3_bin.9.fa -m mmseqs --itype genome -o MMS_3_bin.9 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/4635/MMS_3_bin.9 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
MMS3_k127_1103651_22	1056495.Calag_1003	4.79e-12	80.0	COG3391@1|root,arCOG06052@1|root,arCOG02560@2157|Archaea,arCOG06052@2157|Archaea,2XRYP@28889|Crenarchaeota	28889|Crenarchaeota	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_1103651_0	273116.14325462	0.0	1026.0	COG2366@1|root,arCOG04082@2157|Archaea,2XT02@28890|Euryarchaeota,241ZQ@183967|Thermoplasmata	183967|Thermoplasmata	S	Penicillin amidase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
MMS3_k127_1103651_23	697303.Thewi_1848	2.824e-05	51.0	COG1433@1|root,COG1433@2|Bacteria,1VFDZ@1239|Firmicutes,24R8N@186801|Clostridia,42GPN@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM Dinitrogenase iron-molybdenum cofactor biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	Nitro_FeMo-Co
MMS3_k127_1103651_19	997346.HMPREF9374_1780	1.984e-25	117.0	COG3173@1|root,COG3173@2|Bacteria,1TPYB@1239|Firmicutes,4HBYQ@91061|Bacilli,27CG9@186824|Thermoactinomycetaceae	91061|Bacilli	S	Phosphotransferase enzyme family	ycbJ	-	-	ko:K06979	-	M00760	-	-	br01600,ko00000,ko00002,ko01504	-	-	-	APH
MMS3_k127_1103651_4	273075.Ta1069	3.492e-86	299.0	COG0477@1|root,arCOG00132@2157|Archaea,2Y66G@28890|Euryarchaeota,2423W@183967|Thermoplasmata	183967|Thermoplasmata	G	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS3_k127_1103651_13	367336.OM2255_07120	6.141e-51	195.0	COG0620@1|root,COG0620@2|Bacteria,1MUI9@1224|Proteobacteria,2TTWK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Methionine synthase	-	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
MMS3_k127_1103651_17	273063.STK_26070	3.833e-29	118.0	arCOG06030@1|root,arCOG06030@2157|Archaea,2XS4E@28889|Crenarchaeota	28889|Crenarchaeota	S	Ta0938	-	-	-	-	-	-	-	-	-	-	-	-	Ta0938
MMS3_k127_1103651_6	330779.Saci_2243	3.162e-80	277.0	COG5424@1|root,arCOG06031@2157|Archaea,2XRWB@28889|Crenarchaeota	28889|Crenarchaeota	H	Iron-containing redox enzyme	-	-	1.3.3.11	ko:K06137	-	-	-	-	ko00000,ko01000	-	-	-	TENA_THI-4,zf-C2H2_9
MMS3_k127_1103651_11	1304872.JAGC01000003_gene2533	5.504e-58	209.0	COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,1MUDN@1224|Proteobacteria,42N3H@68525|delta/epsilon subdivisions,2WJSC@28221|Deltaproteobacteria,2MA27@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Rhodanese domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B,Rhodanese
MMS3_k127_1103651_8	273116.14324798	4.205e-65	239.0	COG0515@1|root,arCOG07377@2157|Archaea	2157|Archaea	KLT	Protein kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_1103651_21	56110.Oscil6304_3815	9.724e-17	90.0	COG0631@1|root,COG0631@2|Bacteria	2|Bacteria	T	protein serine/threonine phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	PP2C_2
MMS3_k127_1103651_5	273116.14324796	9.347e-85	288.0	arCOG07379@1|root,arCOG07379@2157|Archaea	2157|Archaea	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_1103651_12	263820.PTO1116	3.06e-57	209.0	COG1052@1|root,arCOG01755@2157|Archaea,2XZQ9@28890|Euryarchaeota,24272@183967|Thermoplasmata	183967|Thermoplasmata	C	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	-	-	1.1.1.29	ko:K00018	ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200	M00346	R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko00002,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
MMS3_k127_1103651_2	1041930.Mtc_0248	1.959e-144	472.0	COG0441@1|root,arCOG00401@2157|Archaea,2XTFI@28890|Euryarchaeota,2N9FW@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-Thr_ED,tRNA-synt_2b,tRNA_SAD
MMS3_k127_1103651_18	263820.PTO0890	9.424e-27	117.0	COG0500@1|root,arCOG02702@2157|Archaea	2157|Archaea	Q	Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_31
MMS3_k127_1103651_1	273116.14324614	3.708e-177	568.0	COG1012@1|root,arCOG01252@2157|Archaea,2XT1Y@28890|Euryarchaeota	28890|Euryarchaeota	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.16,1.2.1.20,1.2.1.3,1.2.1.79,1.2.1.8	ko:K00128,ko:K00130,ko:K00135	ko00010,ko00053,ko00071,ko00250,ko00260,ko00280,ko00310,ko00330,ko00340,ko00350,ko00380,ko00410,ko00561,ko00620,ko00625,ko00650,ko00760,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00250,map00260,map00280,map00310,map00330,map00340,map00350,map00380,map00410,map00561,map00620,map00625,map00650,map00760,map00903,map00981,map01100,map01110,map01120,map01130	M00027,M00135,M00555	R00264,R00631,R00710,R00713,R00714,R00904,R01752,R01986,R02401,R02549,R02565,R02566,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
MMS3_k127_1103651_3	273116.14324613	1.517e-108	363.0	COG1454@1|root,arCOG00984@2157|Archaea,2XU9N@28890|Euryarchaeota	28890|Euryarchaeota	C	alcohol dehydrogenase	-	-	1.1.1.1	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
MMS3_k127_1103651_14	273116.14324612	2.027e-49	179.0	COG3255@1|root,arCOG01842@2157|Archaea,2XXJM@28890|Euryarchaeota	28890|Euryarchaeota	I	sterol carrier protein	-	-	-	-	-	-	-	-	-	-	-	-	SCP2
MMS3_k127_1103651_16	263820.PTO0059	6.963e-33	133.0	COG0500@1|root,arCOG05319@2157|Archaea	2157|Archaea	H	PFAM Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
MMS3_k127_1103651_15	273075.Ta1460	2.233e-37	152.0	COG1597@1|root,arCOG08932@2157|Archaea	2157|Archaea	I	COG1597 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
MMS3_k127_1103651_10	1487956.DR71_437	1.713e-58	222.0	COG0277@1|root,COG0277@2|Bacteria,2GIS6@201174|Actinobacteria,22M0N@1653|Corynebacteriaceae	201174|Actinobacteria	C	FAD linked oxidases, C-terminal domain	eapA	-	2.5.1.26	ko:K00803	ko00565,ko01100,ko04146,map00565,map01100,map04146	-	R04311	RC00020,RC02886	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
MMS3_k127_1103651_7	273057.SSO2087	3.357e-72	252.0	COG0412@1|root,arCOG01659@2157|Archaea,2XRM2@28889|Crenarchaeota	28889|Crenarchaeota	Q	dienelactone hydrolase	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
MMS3_k127_1103651_9	397948.Cmaq_1209	1.22e-61	221.0	COG1058@1|root,arCOG00215@2157|Archaea,2XQA2@28889|Crenarchaeota	28889|Crenarchaeota	S	molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	MoCF_biosynth
MMS3_k127_1103651_20	390989.JOEG01000003_gene4702	3.103e-24	109.0	COG0842@1|root,COG0842@2|Bacteria,2GJ2G@201174|Actinobacteria,4DDT9@85008|Micromonosporales	201174|Actinobacteria	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane,ABC2_membrane_3
MMS3_k127_112209_2	273063.STK_12180	6.282e-84	286.0	COG0111@1|root,arCOG01754@2157|Archaea,2XPRE@28889|Crenarchaeota	28889|Crenarchaeota	C	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
MMS3_k127_112209_3	933801.Ahos_1338	2.622e-76	268.0	COG0075@1|root,arCOG00082@2157|Archaea,2XQJ2@28889|Crenarchaeota	28889|Crenarchaeota	E	PFAM aminotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
MMS3_k127_112209_0	273116.14325304	2.276e-161	522.0	COG0016@1|root,arCOG00410@2157|Archaea,2XSTK@28890|Euryarchaeota,241IU@183967|Thermoplasmata	183967|Thermoplasmata	J	phenylalanine-tRNA ligase activity	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2d
MMS3_k127_112209_1	1356854.N007_16090	2.999e-110	366.0	COG0604@1|root,COG0604@2|Bacteria,1TRNC@1239|Firmicutes,4HATC@91061|Bacilli,279DK@186823|Alicyclobacillaceae	91061|Bacilli	C	Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily	qor	-	1.1.1.1,1.6.5.5	ko:K00001,ko:K00344	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
MMS3_k127_112209_6	273116.14324453	1.122e-07	65.0	arCOG03675@1|root,arCOG06052@1|root,arCOG03675@2157|Archaea,arCOG06052@2157|Archaea	2157|Archaea	S	Thermopsin	-	-	3.4.23.42	ko:K01385	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	CARDB,Thermopsin
MMS3_k127_112209_4	273063.STK_10340	1.696e-71	250.0	COG1131@1|root,arCOG00194@2157|Archaea	2157|Archaea	V	ABC-type multidrug transport system ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
MMS3_k127_1182995_25	572478.Vdis_0373	0.0001034	52.0	COG1547@1|root,arCOG03705@2157|Archaea,2XSJA@28889|Crenarchaeota	28889|Crenarchaeota	S	Domain of unknown function (DUF309)	-	-	-	-	-	-	-	-	-	-	-	-	DUF309
MMS3_k127_1182995_4	263820.PTO1412	2.347e-209	657.0	COG0017@1|root,arCOG00407@2157|Archaea,2XTZJ@28890|Euryarchaeota,241ZH@183967|Thermoplasmata	183967|Thermoplasmata	J	asparaginyl-tRNA aminoacylation	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.1.1.22	ko:K01893	ko00970,map00970	M00359,M00360	R03648	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
MMS3_k127_1182995_11	263820.PTO1413	5.043e-86	295.0	COG0407@1|root,arCOG03323@2157|Archaea,2XV21@28890|Euryarchaeota,2424C@183967|Thermoplasmata	183967|Thermoplasmata	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	hemE	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
MMS3_k127_1182995_17	273075.Ta0311	1.463e-56	208.0	COG0276@1|root,arCOG05373@2157|Archaea,2XTYB@28890|Euryarchaeota,24260@183967|Thermoplasmata	183967|Thermoplasmata	H	Catalyzes the ferrous insertion into protoporphyrin IX	hemH	-	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	Ferrochelatase
MMS3_k127_1182995_15	273116.14324578	6.778e-59	216.0	COG3276@1|root,arCOG01564@2157|Archaea,2XWBV@28890|Euryarchaeota,241RR@183967|Thermoplasmata	183967|Thermoplasmata	J	PFAM elongation factor Tu, domain 2 protein	-	-	-	-	-	-	-	-	-	-	-	-	GTP_EFTU_D2
MMS3_k127_1182995_16	768679.TTX_0182	8.106e-59	211.0	COG2220@1|root,arCOG00497@2157|Archaea,2XPSC@28889|Crenarchaeota	28889|Crenarchaeota	S	Belongs to the UPF0173 family	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2,Lactamase_B_3
MMS3_k127_1182995_5	273116.14324840	1.688e-129	428.0	COG0151@1|root,arCOG04415@2157|Archaea,2XTRV@28890|Euryarchaeota,241JT@183967|Thermoplasmata	183967|Thermoplasmata	F	Phosphoribosylglycinamide synthetase, C domain	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
MMS3_k127_1182995_21	263820.PTO0951	1.926e-27	117.0	COG1386@1|root,arCOG02613@2157|Archaea	2157|Archaea	K	Segregation and condensation protein	scpB	-	2.8.1.1,2.8.1.2	ko:K01011,ko:K06024	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000,ko03036	-	-	-	SMC_ScpB
MMS3_k127_1182995_23	263820.PTO0333	2.31e-11	79.0	COG3391@1|root,arCOG06052@1|root,arCOG02560@2157|Archaea,arCOG06052@2157|Archaea,2Y65W@28890|Euryarchaeota,242AM@183967|Thermoplasmata	183967|Thermoplasmata	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_1182995_7	263820.PTO0131	6.074e-97	332.0	COG1457@1|root,arCOG03447@2157|Archaea,2Y0SR@28890|Euryarchaeota,24241@183967|Thermoplasmata	183967|Thermoplasmata	F	Permease for cytosine/purines, uracil, thiamine, allantoin	-	-	-	ko:K03457	-	-	-	-	ko00000	2.A.39	-	-	Transp_cyt_pur
MMS3_k127_1182995_19	273075.Ta0598m	2.1e-41	157.0	COG0717@1|root,arCOG04048@2157|Archaea,2Y6CE@28890|Euryarchaeota,241VF@183967|Thermoplasmata	183967|Thermoplasmata	F	dUTPase	-	-	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	dUTPase
MMS3_k127_1182995_6	273075.Ta1155	4.191e-122	398.0	COG1234@1|root,arCOG00501@2157|Archaea,2XTJ9@28890|Euryarchaeota,241Q1@183967|Thermoplasmata	183967|Thermoplasmata	J	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA	rnz	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
MMS3_k127_1182995_20	273116.14325497	1.321e-28	120.0	COG1658@1|root,arCOG01486@2157|Archaea	2157|Archaea	L	Belongs to the UPF0292 family	-	-	-	-	-	-	-	-	-	-	-	-	Toprim,Toprim_4
MMS3_k127_1182995_1	273075.Ta0838	0.0	1052.0	COG1201@1|root,arCOG00557@2157|Archaea,2XSTH@28890|Euryarchaeota,241ID@183967|Thermoplasmata	183967|Thermoplasmata	L	helicase superfamily c-terminal domain	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
MMS3_k127_1182995_3	273116.14324736	9.046e-237	754.0	COG0046@1|root,arCOG00641@2157|Archaea,2XU49@28890|Euryarchaeota,241M2@183967|Thermoplasmata	183967|Thermoplasmata	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
MMS3_k127_1182995_22	263820.PTO1204	1.156e-12	71.0	COG1828@1|root,arCOG04462@2157|Archaea,2Y79Q@28890|Euryarchaeota,241WD@183967|Thermoplasmata	183967|Thermoplasmata	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purS	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	PurS
MMS3_k127_1182995_10	263820.PTO0183	1.732e-86	292.0	COG1646@1|root,arCOG01085@2157|Archaea,2XTEC@28890|Euryarchaeota,241NR@183967|Thermoplasmata	183967|Thermoplasmata	H	Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids	-	-	2.5.1.41	ko:K17104	ko00564,map00564	-	R04158	RC01091	ko00000,ko00001,ko01000	-	-	-	PcrB
MMS3_k127_1182995_14	273075.Ta0996m	3.839e-68	241.0	COG0382@1|root,arCOG00476@2157|Archaea,2XUHS@28890|Euryarchaeota,241QE@183967|Thermoplasmata	183967|Thermoplasmata	H	UbiA prenyltransferase family	-	-	2.5.1.42	ko:K17105	ko00564,map00564	-	R04520	RC01171	ko00000,ko00001,ko01000	-	-	-	UbiA
MMS3_k127_1182995_8	263820.PTO0220	5.022e-92	314.0	COG1867@1|root,arCOG01219@2157|Archaea,2XTUF@28890|Euryarchaeota,241SG@183967|Thermoplasmata	183967|Thermoplasmata	J	Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups	trm1	-	2.1.1.215,2.1.1.216	ko:K00555	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TRM
MMS3_k127_1182995_12	273116.14324964	1.032e-78	267.0	COG1618@1|root,arCOG01034@2157|Archaea,2XX6U@28890|Euryarchaeota,241QZ@183967|Thermoplasmata	183967|Thermoplasmata	F	Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency	-	-	3.6.1.15	ko:K06928	ko00230,ko00730,ko01100,map00230,map00730,map01100	-	R00086,R00615	RC00002	ko00000,ko00001,ko01000	-	-	-	NTPase_1
MMS3_k127_1182995_18	273116.14324965	7.796e-48	174.0	COG2098@1|root,arCOG04705@2157|Archaea,2XY43@28890|Euryarchaeota,241TA@183967|Thermoplasmata	183967|Thermoplasmata	S	Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD)	mptD	-	4.1.2.25	ko:K09739	ko00790,map00790	-	R03504	RC00721,RC00943	ko00000,ko00001,ko01000	-	-	-	DHNA
MMS3_k127_1182995_26	160799.PBOR_11920	0.0001357	55.0	COG2931@1|root,COG3391@1|root,COG2931@2|Bacteria,COG3391@2|Bacteria,1V255@1239|Firmicutes,4HFUF@91061|Bacilli,26VZT@186822|Paenibacillaceae	91061|Bacilli	M	40-residue YVTN family beta-propeller repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	Collagen,Cytochrom_D1,Lactonase,PD40,Phosphoesterase
MMS3_k127_1182995_0	273116.14325177	0.0	1063.0	COG1964@1|root,arCOG00933@2157|Archaea,2XTMK@28890|Euryarchaeota,241JK@183967|Thermoplasmata	183967|Thermoplasmata	S	4Fe-4S single cluster domain	-	-	-	ko:K06937	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_14,Radical_SAM
MMS3_k127_1182995_24	273116.14325178	1.982e-09	64.0	COG1371@1|root,arCOG04055@2157|Archaea,2Y6BE@28890|Euryarchaeota,242CD@183967|Thermoplasmata	183967|Thermoplasmata	J	Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently (By similarity)	-	-	-	-	-	-	-	-	-	-	-	-	Archease
MMS3_k127_1182995_13	273075.Ta0778	5.681e-77	261.0	COG1945@1|root,arCOG04490@2157|Archaea,2XY3V@28890|Euryarchaeota,24249@183967|Thermoplasmata	183967|Thermoplasmata	E	arginine decarboxylase activity	pdaD	-	4.1.1.19	ko:K02626	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PvlArgDC
MMS3_k127_1182995_2	263820.PTO1191	1.472e-291	920.0	COG0495@1|root,arCOG00809@2157|Archaea,2XU7M@28890|Euryarchaeota,241JC@183967|Thermoplasmata	183967|Thermoplasmata	J	leucyl-tRNA aminoacylation	leuS	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1
MMS3_k127_1182995_9	1047013.AQSP01000037_gene1326	1.872e-89	300.0	COG1830@1|root,COG1830@2|Bacteria,2NPYC@2323|unclassified Bacteria	2|Bacteria	G	DeoC/LacD family aldolase	lsrF	GO:0003674,GO:0003824,GO:0016740,GO:0016746,GO:0016747	2.3.1.245,4.1.2.13	ko:K08321,ko:K11645	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko02024,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map02024	M00001,M00003	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	DeoC
MMS3_k127_1198153_0	273063.STK_00640	1.167e-103	354.0	COG1012@1|root,arCOG01252@2157|Archaea,2XRNH@28889|Crenarchaeota	28889|Crenarchaeota	C	PFAM Aldehyde dehydrogenase	-	-	1.2.1.76	ko:K15038	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00374,M00375	R09280	RC00004,RC00184	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
MMS3_k127_1198153_5	1304877.KI519399_gene3489	1.382e-87	297.0	COG0596@1|root,COG0596@2|Bacteria,1NUT9@1224|Proteobacteria,2TVMS@28211|Alphaproteobacteria,3JT3H@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
MMS3_k127_1198153_22	1123024.AUII01000009_gene2041	5.435e-17	86.0	COG3255@1|root,COG3255@2|Bacteria,2IIU6@201174|Actinobacteria	201174|Actinobacteria	I	Sterol carrier protein	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_1198153_12	562970.Btus_0899	6.352e-55	209.0	COG2271@1|root,COG2271@2|Bacteria,1VXZM@1239|Firmicutes,4HXI8@91061|Bacilli,27A6K@186823|Alicyclobacillaceae	91061|Bacilli	G	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS3_k127_1198153_13	696369.KI912183_gene43	2.213e-53	203.0	COG1454@1|root,COG1454@2|Bacteria,1TPB4@1239|Firmicutes,247IQ@186801|Clostridia	1239|Firmicutes	C	alcohol dehydrogenase	-	-	1.1.1.1	ko:K13954	ko00010,ko00071,ko00350,ko00625,ko00626,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R04880,R05233,R05234,R06917,R06927	RC00050,RC00088,RC00099,RC00116,RC00649	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
MMS3_k127_1198153_9	273116.14325624	3.661e-65	237.0	COG1473@1|root,arCOG01108@2157|Archaea,2XUUS@28890|Euryarchaeota,2423B@183967|Thermoplasmata	183967|Thermoplasmata	S	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer
MMS3_k127_1198153_19	263820.PTO0396	5.303e-24	117.0	COG1468@1|root,arCOG00790@2157|Archaea	2157|Archaea	L	CRISPR-associated protein Cas4	-	GO:0000014,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004527,GO:0004529,GO:0004536,GO:0005488,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008297,GO:0008409,GO:0009987,GO:0016043,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0032392,GO:0032508,GO:0034641,GO:0035312,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0045145,GO:0046483,GO:0048037,GO:0051276,GO:0051536,GO:0051537,GO:0051540,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0140097,GO:1901360	3.1.12.1	ko:K07464	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	Cas_Cas4,PDDEXK_1
MMS3_k127_1198153_11	273075.Ta0056	4.476e-60	213.0	COG0461@1|root,arCOG00029@2157|Archaea,2XVNG@28890|Euryarchaeota,241R4@183967|Thermoplasmata	183967|Thermoplasmata	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
MMS3_k127_1198153_16	1459636.NTE_00049	8.238e-43	163.0	COG2062@1|root,arCOG01992@2157|Archaea	2157|Archaea	T	TIGRFAM phosphohistidine phosphatase SixA	sixA	-	-	ko:K08296	-	-	-	-	ko00000,ko01000	-	-	-	His_Phos_1
MMS3_k127_1198153_1	1459636.NTE_00050	7.855e-100	344.0	COG0248@1|root,arCOG05138@2157|Archaea	2157|Archaea	FP	PFAM Ppx GppA phosphatase	ppx	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	HD,Ppx-GppA
MMS3_k127_1198153_3	1459636.NTE_00051	2.502e-91	305.0	COG0125@1|root,arCOG01891@2157|Archaea	2157|Archaea	F	thymidylate kinase	-	GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
MMS3_k127_1198153_6	1459636.NTE_00052	2.744e-81	276.0	COG0125@1|root,arCOG01891@2157|Archaea	1459636.NTE_00052|-	F	thymidylate kinase	-	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	-
MMS3_k127_1198153_17	67332.FM21_16340	1.057e-30	128.0	COG0500@1|root,COG2226@2|Bacteria,2GKPQ@201174|Actinobacteria	201174|Actinobacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
MMS3_k127_1198153_8	33876.JNXY01000045_gene1934	2.758e-66	236.0	COG0596@1|root,COG0596@2|Bacteria,2IFCI@201174|Actinobacteria,4DC31@85008|Micromonosporales	201174|Actinobacteria	S	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
MMS3_k127_1198153_21	1205910.B005_5413	3.78e-20	94.0	COG2343@1|root,COG2343@2|Bacteria,2IKUM@201174|Actinobacteria	201174|Actinobacteria	IQ	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_9
MMS3_k127_1198153_18	591019.Shell_0393	3.867e-24	110.0	COG2013@1|root,arCOG01907@2157|Archaea,2XQ76@28889|Crenarchaeota	28889|Crenarchaeota	S	Mitochondrial biogenesis AIM24	-	-	-	-	-	-	-	-	-	-	-	-	AIM24
MMS3_k127_1198153_20	1122221.JHVI01000020_gene1120	8.344e-24	106.0	COG3427@1|root,COG3427@2|Bacteria	2|Bacteria	E	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	ko:K09386	-	-	-	-	ko00000	-	-	-	COXG
MMS3_k127_1198153_10	1229909.NSED_01010	2.627e-63	226.0	COG1801@1|root,arCOG04291@2157|Archaea,41T6J@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
MMS3_k127_1198153_25	397948.Cmaq_0355	7.34e-06	56.0	COG0454@1|root,arCOG00845@2157|Archaea	2157|Archaea	K	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases	-	-	2.3.1.82	ko:K18816	-	-	-	-	br01600,ko00000,ko01000,ko01504	-	-	-	Acetyltransf_1
MMS3_k127_1198153_23	926560.KE387027_gene822	3.674e-13	77.0	COG0454@1|root,COG0456@2|Bacteria,1WMTD@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_9
MMS3_k127_1198153_15	714961.BFZC1_13453	2.861e-44	168.0	COG1670@1|root,COG1670@2|Bacteria,1V5BA@1239|Firmicutes,4HHR5@91061|Bacilli,3IXHY@400634|Lysinibacillus	91061|Bacilli	J	GNAT family acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
MMS3_k127_1198153_14	266117.Rxyl_1661	2.423e-53	192.0	COG1247@1|root,COG1247@2|Bacteria,2H1MI@201174|Actinobacteria,4CQH6@84995|Rubrobacteria	84995|Rubrobacteria	M	Acetyltransferase (GNAT) domain	-	-	2.3.1.183	ko:K03823	ko00440,ko01130,map00440,map01130	-	R08871,R08938	RC00004,RC00064	ko00000,ko00001,ko01000	-	-	-	Acetyltransf_4
MMS3_k127_1198153_4	263820.PTO0184	2.392e-88	301.0	COG1878@1|root,arCOG02462@2157|Archaea,2XX0R@28890|Euryarchaeota	28890|Euryarchaeota	E	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
MMS3_k127_1198153_2	273075.Ta0861	2.829e-93	315.0	COG0281@1|root,arCOG01331@2157|Archaea,2XTRZ@28890|Euryarchaeota,242D0@183967|Thermoplasmata	183967|Thermoplasmata	O	Peptidase family M48	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
MMS3_k127_1198153_7	1382304.JNIL01000001_gene2947	6.055e-69	241.0	COG0584@1|root,COG0584@2|Bacteria,1V3W4@1239|Firmicutes	1239|Firmicutes	C	glycerophosphoryl diester phosphodiesterase	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	Big_2,GDPD,GPDPase_memb
MMS3_k127_1198153_26	390989.JOEG01000007_gene712	1.183e-05	49.0	COG0477@1|root,COG2814@2|Bacteria,2GJF6@201174|Actinobacteria,4DA3F@85008|Micromonosporales	201174|Actinobacteria	EGP	Sugar (and other) transporter	ydjE	-	-	ko:K08368	-	-	-	-	ko00000,ko02000	2.A.1	-	-	Sugar_tr
MMS3_k127_1200873_0	273075.Ta0481	2.398e-239	756.0	COG1028@1|root,arCOG01259@2157|Archaea	2157|Archaea	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
MMS3_k127_1200873_6	263820.PTO1193	4.173e-81	280.0	COG0644@1|root,arCOG00570@2157|Archaea,2XUCU@28890|Euryarchaeota,2421U@183967|Thermoplasmata	183967|Thermoplasmata	C	Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_1200873_9	263820.PTO0780	1.022e-50	189.0	COG0101@1|root,arCOG04449@2157|Archaea,2XTH5@28890|Euryarchaeota,241WS@183967|Thermoplasmata	183967|Thermoplasmata	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	-	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
MMS3_k127_1200873_1	273116.14325499	3.366e-216	685.0	COG1793@1|root,arCOG01347@2157|Archaea,2XTCK@28890|Euryarchaeota,241JJ@183967|Thermoplasmata	183967|Thermoplasmata	L	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair	lig	-	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N
MMS3_k127_1200873_8	273075.Ta1149	1.913e-51	187.0	COG1599@1|root,arCOG01510@2157|Archaea,2Y7BB@28890|Euryarchaeota,242B4@183967|Thermoplasmata	183967|Thermoplasmata	L	COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins	-	-	-	ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko03000,ko03032,ko03400	-	-	-	-
MMS3_k127_1200873_13	1006006.Mcup_1637	1.99e-13	74.0	COG3370@1|root,arCOG01668@2157|Archaea,2XS6U@28889|Crenarchaeota	28889|Crenarchaeota	S	DsrE/DsrF-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE
MMS3_k127_1200873_5	263820.PTO0127	2.137e-82	288.0	COG0477@1|root,arCOG00130@2157|Archaea,2Y7A7@28890|Euryarchaeota,241ZW@183967|Thermoplasmata	183967|Thermoplasmata	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS3_k127_1200873_14	247156.PNF1_610	2.733e-09	67.0	COG0428@1|root,COG0428@2|Bacteria,2ICIQ@201174|Actinobacteria,4FY5S@85025|Nocardiaceae	201174|Actinobacteria	P	Mediates zinc uptake. May also transport other divalent cations	zupT	-	-	-	-	-	-	-	-	-	-	-	Zip
MMS3_k127_1200873_4	1056495.Calag_0283	7.586e-94	316.0	COG1741@1|root,arCOG02935@2157|Archaea,2XRMP@28889|Crenarchaeota	28889|Crenarchaeota	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
MMS3_k127_1200873_10	933801.Ahos_0164	1.707e-41	178.0	COG3391@1|root,arCOG06052@1|root,arCOG02560@2157|Archaea,arCOG06052@2157|Archaea,2XRYP@28889|Crenarchaeota	28889|Crenarchaeota	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_1200873_12	263820.PTO0774	1.743e-22	115.0	arCOG06052@1|root,arCOG06052@2157|Archaea	2157|Archaea	-	-	-	-	3.4.23.42	ko:K01385	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	CARDB
MMS3_k127_1200873_2	273116.14325459	7.039e-168	541.0	COG0028@1|root,arCOG03656@2157|Archaea,2XSZ0@28890|Euryarchaeota,242I3@183967|Thermoplasmata	183967|Thermoplasmata	E	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain	-	-	4.1.1.7	ko:K01576	ko00627,ko01120,map00627,map01120	-	R01764,R02672	RC00595	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
MMS3_k127_1200873_3	273116.14325460	3.634e-116	382.0	COG0111@1|root,arCOG01754@2157|Archaea,2XU9V@28890|Euryarchaeota,242A2@183967|Thermoplasmata	183967|Thermoplasmata	H	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
MMS3_k127_1200873_7	1172562.HCN_1558	6.038e-66	238.0	COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,42N31@68525|delta/epsilon subdivisions,2YN6V@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	C	also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity	prpC	-	2.3.3.5	ko:K01659	ko00640,map00640	-	R00931	RC00004,RC00406,RC02827	ko00000,ko00001,ko01000	-	-	-	Citrate_synt
MMS3_k127_1200873_11	1121087.AUCK01000025_gene1815	6.383e-29	118.0	COG0163@1|root,COG0163@2|Bacteria,1V3JV@1239|Firmicutes,4HFZX@91061|Bacilli,1ZFID@1386|Bacillus	91061|Bacilli	H	Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN	ubiX	GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0044237,GO:0044249,GO:0051186,GO:0051188	2.5.1.129	ko:K03186	ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220	M00117	R01238,R02952,R03367,R04985,R04986,R11225	RC00391,RC00814,RC03392	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavoprotein
MMS3_k127_1691335_0	935837.JAEK01000039_gene3897	3.01e-124	406.0	COG0667@1|root,COG0667@2|Bacteria,1TQJC@1239|Firmicutes,4HC0W@91061|Bacilli,1ZD59@1386|Bacillus	91061|Bacilli	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
MMS3_k127_1691335_1	1444309.JAQG01000181_gene3491	4.215e-27	117.0	COG3797@1|root,COG3797@2|Bacteria,1V4KG@1239|Firmicutes,4HIGT@91061|Bacilli,26WVR@186822|Paenibacillaceae	91061|Bacilli	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF1697
MMS3_k127_1702345_11	264198.Reut_C6210	1.486e-44	172.0	COG1073@1|root,COG1073@2|Bacteria,1MXJ3@1224|Proteobacteria,2VX9A@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Prolyl oligopeptidase family	-	-	-	-	-	-	-	-	-	-	-	-	DUF1100,Peptidase_S9
MMS3_k127_1702345_6	756499.Desde_0810	6.662e-79	284.0	COG0028@1|root,COG0028@2|Bacteria,1TSBQ@1239|Firmicutes,24YTB@186801|Clostridia,264KR@186807|Peptococcaceae	186801|Clostridia	EH	Belongs to the TPP enzyme family	-	-	2.3.3.15	ko:K03852	ko00430,map00430	-	R05651	RC02903,RC02909	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
MMS3_k127_1702345_1	1041147.AUFB01000020_gene5427	2.196e-124	414.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,4B7AV@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	belongs to the aldehyde dehydrogenase family	-	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
MMS3_k127_1702345_10	1345697.M493_10740	2.707e-59	219.0	COG1149@1|root,COG1149@2|Bacteria,1VSNV@1239|Firmicutes	1239|Firmicutes	C	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_1702345_0	1380358.JADJ01000018_gene2586	1.812e-144	471.0	COG1053@1|root,COG1053@2|Bacteria,1MURY@1224|Proteobacteria,1RNYN@1236|Gammaproteobacteria,1XMVG@135619|Oceanospirillales	135619|Oceanospirillales	C	3-oxosteroid 1-dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_2
MMS3_k127_1702345_9	273075.Ta0854	5.676e-62	218.0	COG0279@1|root,arCOG05355@2157|Archaea,2XUSN@28890|Euryarchaeota,241VQ@183967|Thermoplasmata	183967|Thermoplasmata	G	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate	gmhA	-	5.3.1.28	ko:K03271	ko00540,ko01100,map00540,map01100	M00064	R05645,R09768,R09769	RC00434	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	SIS_2
MMS3_k127_1702345_2	273116.14325123	2.431e-110	366.0	COG2605@1|root,arCOG01030@2157|Archaea,2Y7BC@28890|Euryarchaeota,242B5@183967|Thermoplasmata	183967|Thermoplasmata	S	GHMP kinases C terminal	-	-	2.7.1.168	ko:K07031	ko00540,map00540	-	R09770	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
MMS3_k127_1702345_3	273075.Ta0343	4.568e-107	355.0	COG0451@1|root,arCOG01369@2157|Archaea,2XTTP@28890|Euryarchaeota	28890|Euryarchaeota	M	NAD-dependent epimerase dehydratase	-	-	5.1.3.2,5.1.3.20	ko:K01784,ko:K03274	ko00052,ko00520,ko00540,ko01100,map00052,map00520,map00540,map01100	M00064,M00361,M00362,M00632	R00291,R02984,R05176	RC00289,RC01291	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	iAF692.Mbar_A0021	Epimerase,GDP_Man_Dehyd
MMS3_k127_1702345_8	273116.14325121	1.993e-65	246.0	COG3463@1|root,arCOG03812@2157|Archaea	2157|Archaea	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF2079
MMS3_k127_1702345_4	273116.14325209	6.358e-106	373.0	COG5650@1|root,arCOG03702@2157|Archaea,2Y3AP@28890|Euryarchaeota,2423M@183967|Thermoplasmata	183967|Thermoplasmata	S	pathogenesis	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_1702345_7	186497.PF0058	1.996e-78	274.0	COG0463@1|root,arCOG00894@2157|Archaea,2XWXA@28890|Euryarchaeota,242RY@183968|Thermococci	183968|Thermococci	M	GtrA-like protein	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2,GtrA
MMS3_k127_1702345_12	273116.14325208	3.63e-06	55.0	COG2246@1|root,arCOG02228@2157|Archaea,2Y1ZX@28890|Euryarchaeota,242GP@183967|Thermoplasmata	183967|Thermoplasmata	S	GtrA-like protein	-	-	-	ko:K00786	-	-	-	-	ko00000,ko01000	-	-	-	GtrA
MMS3_k127_1702345_5	263820.PTO0312	2.125e-87	295.0	COG0451@1|root,arCOG04627@2157|Archaea,2Y34E@28890|Euryarchaeota,24206@183967|Thermoplasmata	183967|Thermoplasmata	M	GDP-mannose 4,6 dehydratase	-	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
MMS3_k127_1702435_7	264198.Reut_C6210	3.971e-43	168.0	COG1073@1|root,COG1073@2|Bacteria,1MXJ3@1224|Proteobacteria,2VX9A@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Prolyl oligopeptidase family	-	-	-	-	-	-	-	-	-	-	-	-	DUF1100,Peptidase_S9
MMS3_k127_1702435_3	1408224.SAMCCGM7_c1878	9.584e-54	200.0	COG3246@1|root,COG3246@2|Bacteria,1MZTP@1224|Proteobacteria	1224|Proteobacteria	K	3-keto-5-aminohexanoate cleavage protein	-	-	2.3.1.247	ko:K18013	ko00310,map00310	-	R10564	RC02728,RC03199	ko00000,ko00001,ko01000	-	-	-	BKACE
MMS3_k127_1702435_0	985053.VMUT_1229	7.416e-95	319.0	arCOG06505@1|root,arCOG06505@2157|Archaea,2XRQB@28889|Crenarchaeota	28889|Crenarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_1702435_9	1027292.HMPREF9372_2073	2.963e-23	113.0	COG2271@1|root,COG2271@2|Bacteria,1V0VC@1239|Firmicutes,4HCQG@91061|Bacilli	91061|Bacilli	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
MMS3_k127_1702435_1	399549.Msed_1059	2.278e-93	316.0	COG0111@1|root,arCOG01754@2157|Archaea,2XSQK@28889|Crenarchaeota	28889|Crenarchaeota	C	D-isomer specific 2-hydroxyacid dehydrogenase catalytic	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
MMS3_k127_1702435_5	671065.MetMK1DRAFT_00001030	4.911e-48	189.0	COG0477@1|root,arCOG02682@2157|Archaea	2157|Archaea	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Sugar_tr
MMS3_k127_1702435_8	757424.Hsero_0959	2.758e-27	123.0	COG2084@1|root,COG2084@2|Bacteria,1MWR4@1224|Proteobacteria,2VKS5@28216|Betaproteobacteria	28216|Betaproteobacteria	I	3-Hydroxyisobutyrate dehydrogenase	-	-	1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
MMS3_k127_1702435_4	931627.MycrhDRAFT_1660	1.151e-53	200.0	COG1878@1|root,COG1878@2|Bacteria,2GJ59@201174|Actinobacteria	201174|Actinobacteria	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
MMS3_k127_1702435_6	1331060.RLDS_06070	2.978e-44	173.0	COG0179@1|root,COG0179@2|Bacteria,1MUPF@1224|Proteobacteria	1224|Proteobacteria	Q	COG0179 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)	-	-	4.1.1.68	ko:K05921	ko00350,ko01120,ko01220,map00350,map01120,map01220	M00533	R04134,R04380	RC01085,RC02669	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF2437,FAA_hydrolase
MMS3_k127_1702435_2	760011.Spico_1043	5.657e-55	202.0	COG3246@1|root,COG3246@2|Bacteria	2|Bacteria	K	L-lysine catabolic process to acetate	-	-	2.3.1.247	ko:K18013	ko00310,map00310	-	R10564	RC02728,RC03199	ko00000,ko00001,ko01000	-	-	-	BKACE
MMS3_k127_1772557_6	673860.AciM339_0322	6.606e-199	637.0	COG1389@1|root,arCOG01165@2157|Archaea,2XTZQ@28890|Euryarchaeota,3F2EU@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Relaxes both positive and negative superturns and exhibits a strong decatenase activity	top6B	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	5.99.1.3	ko:K03167	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	HATPase_c,Topo-VIb_trans
MMS3_k127_1772557_11	673860.AciM339_0321	7.788e-162	516.0	COG1697@1|root,arCOG04143@2157|Archaea,2XTNQ@28890|Euryarchaeota,3F2HT@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Relaxes both positive and negative superturns and exhibits a strong decatenase activity	top6A	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003918,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0016889,GO:0016894,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0061505,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363	5.99.1.3	ko:K03166	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	TP6A_N
MMS3_k127_1772557_57	273075.Ta1208	3.106e-58	211.0	COG0388@1|root,arCOG00062@2157|Archaea,2XT6R@28890|Euryarchaeota,241X5@183967|Thermoplasmata	183967|Thermoplasmata	S	Carbon-nitrogen hydrolase	-	-	3.5.1.100	ko:K18540	-	-	-	-	ko00000,ko01000	-	-	-	CN_hydrolase
MMS3_k127_1772557_62	273116.14325517	1.571e-52	194.0	COG1877@1|root,arCOG01216@2157|Archaea,2Y7BA@28890|Euryarchaeota,242AK@183967|Thermoplasmata	183967|Thermoplasmata	G	Removes the phosphate from trehalose 6-phosphate	-	GO:0000287,GO:0003674,GO:0003824,GO:0004805,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872	3.1.3.12	ko:K01087	ko00500,ko01100,map00500,map01100	-	R02778	RC00017	ko00000,ko00001,ko01000	-	-	-	Trehalose_PPase
MMS3_k127_1772557_12	273075.Ta1210	4.358e-161	518.0	COG0380@1|root,arCOG02831@2157|Archaea,2XSTE@28890|Euryarchaeota,241YH@183967|Thermoplasmata	183967|Thermoplasmata	G	Glycosyltransferase family 20	-	-	2.4.1.15,2.4.1.347	ko:K00697	ko00500,ko01100,map00500,map01100	-	R02737	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT20	-	Glyco_transf_20
MMS3_k127_1772557_78	269797.Mbar_A2985	1.272e-29	133.0	COG0668@1|root,arCOG01568@2157|Archaea,2XSU5@28890|Euryarchaeota	28890|Euryarchaeota	M	COG0668 Small-conductance mechanosensitive channel	mscS1	-	-	ko:K16052	-	-	-	-	ko00000,ko02000	1.A.23.4	-	-	MS_channel
MMS3_k127_1772557_39	273063.STK_11490	4.452e-80	274.0	COG3342@1|root,arCOG04204@2157|Archaea,2XQSJ@28889|Crenarchaeota	28889|Crenarchaeota	S	Family of unknown function (DUF1028)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1028,PG_binding_2
MMS3_k127_1772557_14	273075.Ta0952	2.747e-150	481.0	COG0039@1|root,arCOG00246@2157|Archaea,2XTQ0@28890|Euryarchaeota,2421M@183967|Thermoplasmata	183967|Thermoplasmata	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	-	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
MMS3_k127_1772557_32	263820.PTO1308	1.208e-92	310.0	COG0603@1|root,arCOG00039@2157|Archaea,2XTS7@28890|Euryarchaeota,241MS@183967|Thermoplasmata	183967|Thermoplasmata	H	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))	queC	-	6.3.4.20	ko:K06920	ko00790,ko01100,map00790,map01100	-	R09978	RC00959	ko00000,ko00001,ko01000,ko03016	-	-	-	QueC
MMS3_k127_1772557_71	273116.14325357	4.619e-37	145.0	COG0720@1|root,arCOG02172@2157|Archaea,2XXFY@28890|Euryarchaeota,241WN@183967|Thermoplasmata	183967|Thermoplasmata	H	6-pyruvoyl tetrahydropterin synthase	-	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
MMS3_k127_1772557_51	263820.PTO0145	1.161e-61	225.0	COG1226@1|root,arCOG01958@2157|Archaea,2Y66E@28890|Euryarchaeota,2429Q@183967|Thermoplasmata	183967|Thermoplasmata	P	Ion channel	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans_2,TrkA_N
MMS3_k127_1772557_35	273116.14325326	6.524e-88	296.0	COG0592@1|root,arCOG00488@2157|Archaea,2XT8B@28890|Euryarchaeota,241SN@183967|Thermoplasmata	183967|Thermoplasmata	L	Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication	pcn	-	-	ko:K04802	ko03030,ko03410,ko03420,ko03430,ko04110,ko04530,ko05161,ko05166,map03030,map03410,map03420,map03430,map04110,map04530,map05161,map05166	M00295	-	-	ko00000,ko00001,ko00002,ko03032,ko03400	-	-	-	PCNA_C,PCNA_N
MMS3_k127_1772557_0	273116.14325315	0.0	1180.0	COG0480@1|root,arCOG01559@2157|Archaea,2XUMQ@28890|Euryarchaeota,241J6@183967|Thermoplasmata	183967|Thermoplasmata	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K03234	ko04152,ko04921,map04152,map04921	-	-	-	ko00000,ko00001,ko03012,ko04147	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
MMS3_k127_1772557_58	273116.14325316	6.963e-57	198.0	COG0051@1|root,arCOG01758@2157|Archaea,2XXV8@28890|Euryarchaeota,241R0@183967|Thermoplasmata	183967|Thermoplasmata	J	Involved in the binding of tRNA to the ribosomes	rps10	-	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
MMS3_k127_1772557_3	273075.Ta0444	2.772e-232	723.0	COG5256@1|root,arCOG01561@2157|Archaea,2XTNM@28890|Euryarchaeota,241IH@183967|Thermoplasmata	183967|Thermoplasmata	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03231	ko03013,ko05134,map03013,map05134	-	-	-	ko00000,ko00001,ko03012,ko03016,ko03019,ko04131,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
MMS3_k127_1772557_52	263820.PTO0414	2.576e-61	220.0	COG3885@1|root,arCOG01729@2157|Archaea,2XYMU@28890|Euryarchaeota,2428X@183967|Thermoplasmata	183967|Thermoplasmata	Q	Catalytic LigB subunit of aromatic ring-opening dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	LigB
MMS3_k127_1772557_41	263820.PTO1226	3.912e-75	263.0	COG0166@1|root,arCOG00052@2157|Archaea,2XYUK@28890|Euryarchaeota,241R6@183967|Thermoplasmata	183967|Thermoplasmata	G	Catalyzes the isomerization of both glucose 6-phosphate and epimeric mannose 6-phosphate at a	-	-	5.3.1.8,5.3.1.9	ko:K15916	ko00010,ko00030,ko00051,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R01819,R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	SIS,bact-PGI_C
MMS3_k127_1772557_8	263820.PTO1225	1.2e-183	592.0	COG1293@1|root,arCOG01695@2157|Archaea,2XTMF@28890|Euryarchaeota,241KK@183967|Thermoplasmata	183967|Thermoplasmata	K	Fibronectin-binding protein A N-terminus (FbpA)	-	-	-	-	-	-	-	-	-	-	-	-	DUF814,FbpA
MMS3_k127_1772557_95	263820.PTO1224	0.0009819	49.0	arCOG07416@1|root,arCOG07416@2157|Archaea	2157|Archaea	S	hydrolases or acyltransferases (alpha beta hydrolase superfamily)	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4
MMS3_k127_1772557_87	797209.ZOD2009_05132	3.162e-17	86.0	COG0824@1|root,arCOG01137@2157|Archaea,2XZ99@28890|Euryarchaeota,23WUB@183963|Halobacteria	183963|Halobacteria	S	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
MMS3_k127_1772557_75	263820.PTO1298	7.735e-33	144.0	arCOG06974@1|root,arCOG06974@2157|Archaea,2Y4TI@28890|Euryarchaeota,242C1@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_1772557_36	263820.PTO1307	3.942e-87	296.0	COG0109@1|root,arCOG00479@2157|Archaea,2XUEM@28890|Euryarchaeota	28890|Euryarchaeota	H	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	ctaB	-	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	COX15-CtaA,UbiA
MMS3_k127_1772557_45	1120971.AUCA01000005_gene2247	4.477e-70	259.0	COG0843@1|root,COG0843@2|Bacteria,1TP2U@1239|Firmicutes,4HA4X@91061|Bacilli,2782I@186823|Alicyclobacillaceae	91061|Bacilli	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	ctaD	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009486,GO:0009987,GO:0015002,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0016491,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0034220,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
MMS3_k127_1772557_90	999630.TUZN_1073	1.097e-14	79.0	COG1622@1|root,arCOG01235@2157|Archaea,2XR96@28889|Crenarchaeota	28889|Crenarchaeota	C	Cytochrome C oxidase subunit II	soxH	-	1.10.3.12,1.9.3.1	ko:K02275,ko:K02826	ko00190,ko01100,map00190,map01100	M00155,M00416	R00081,R09492	RC00016,RC00819	ko00000,ko00001,ko00002,ko01000	3.D.4.1,3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2
MMS3_k127_1772557_13	273116.14324581	2.628e-157	519.0	COG0348@1|root,arCOG03697@2157|Archaea	2157|Archaea	C	4 iron, 4 sulfur cluster binding	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_1772557_7	263820.PTO0807	2.129e-193	608.0	COG1980@1|root,arCOG04180@2157|Archaea,2XTI0@28890|Euryarchaeota,241M4@183967|Thermoplasmata	183967|Thermoplasmata	G	Catalyzes two subsequent steps in gluconeogenesis the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P)	fbp	-	3.1.3.11,4.1.2.13	ko:K01622	ko00010,ko00030,ko00051,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00003	R00762,R01068,R01070,R02568,R04780	RC00017,RC00438,RC00439	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_3
MMS3_k127_1772557_19	263820.PTO0806	1.624e-133	443.0	COG0750@1|root,arCOG04064@2157|Archaea,2XSZP@28890|Euryarchaeota,241RB@183967|Thermoplasmata	183967|Thermoplasmata	M	Peptidase family M50	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
MMS3_k127_1772557_89	273075.Ta1317a	2.966e-16	78.0	COG1552@1|root,arCOG04049@2157|Archaea	2157|Archaea	J	Belongs to the eukaryotic ribosomal protein eL40 family	rpl40e	-	-	ko:K02927	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L40e
MMS3_k127_1772557_38	273075.Ta1318m	3.738e-83	284.0	COG0047@1|root,arCOG00102@2157|Archaea,2XTPA@28890|Euryarchaeota,241Q4@183967|Thermoplasmata	183967|Thermoplasmata	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purQ	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
MMS3_k127_1772557_55	273116.14324493	5.327e-60	213.0	COG0237@1|root,arCOG01045@2157|Archaea,2XWNJ@28890|Euryarchaeota,241SP@183967|Thermoplasmata	183967|Thermoplasmata	H	adenyl ribonucleotide binding	-	-	-	-	-	-	-	-	-	-	-	-	AAA_17
MMS3_k127_1772557_1	263820.PTO1000	3.102e-254	798.0	COG0674@1|root,arCOG01606@2157|Archaea,2XSUJ@28890|Euryarchaeota,2422K@183967|Thermoplasmata	183967|Thermoplasmata	C	Pyruvate:ferredoxin oxidoreductase core domain II	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
MMS3_k127_1772557_24	415426.Hbut_0983	5.168e-115	377.0	COG1013@1|root,arCOG01599@2157|Archaea,2XPQG@28889|Crenarchaeota	28889|Crenarchaeota	C	TIGRFAM pyruvate ferredoxin flavodoxin oxidoreductase, beta subunit	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFO_beta_C,TPP_enzyme_C
MMS3_k127_1772557_81	273075.Ta0875	1.875e-26	115.0	COG1280@1|root,arCOG01947@2157|Archaea,2XURC@28890|Euryarchaeota,24285@183967|Thermoplasmata	183967|Thermoplasmata	E	LysE type translocator	-	-	-	-	-	-	-	-	-	-	-	-	LysE
MMS3_k127_1772557_18	273116.14324985	4.599e-141	460.0	COG1474@1|root,arCOG00467@2157|Archaea,2XU73@28890|Euryarchaeota,241NW@183967|Thermoplasmata	183967|Thermoplasmata	L	Involved in regulation of DNA replication	cdc6	-	-	ko:K10725	-	-	-	-	ko00000,ko03032	-	-	-	AAA_22,Cdc6_C
MMS3_k127_1772557_22	263820.PTO1256	2.516e-129	426.0	COG0294@1|root,arCOG02817@2157|Archaea,2XTGI@28890|Euryarchaeota,241P1@183967|Thermoplasmata	183967|Thermoplasmata	H	Mur ligase family, glutamate ligase domain	-	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M
MMS3_k127_1772557_40	263820.PTO0778	1.069e-79	273.0	COG0013@1|root,arCOG01254@2157|Archaea,2Y3DT@28890|Euryarchaeota,2426U@183967|Thermoplasmata	183967|Thermoplasmata	J	Related to alanyl-tRNA synthetase HxxxH domain	-	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	-
MMS3_k127_1772557_92	273116.14324981	8.46e-11	74.0	arCOG05363@1|root,arCOG05363@2157|Archaea,2Y4TQ@28890|Euryarchaeota,242DI@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_1772557_93	273116.14324597	1.795e-08	57.0	arCOG07405@1|root,arCOG07405@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_1772557_37	263820.PTO0715	5.127e-85	284.0	COG0197@1|root,arCOG04113@2157|Archaea,2XTHT@28890|Euryarchaeota,241RH@183967|Thermoplasmata	183967|Thermoplasmata	J	structural constituent of ribosome	rpl10e	-	-	ko:K02866	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
MMS3_k127_1772557_28	273116.14324753	2.619e-104	346.0	COG0010@1|root,arCOG01700@2157|Archaea,2XTEP@28890|Euryarchaeota,241N8@183967|Thermoplasmata	183967|Thermoplasmata	E	Arginase family	-	-	3.5.3.1,3.5.3.11	ko:K01476,ko:K01480	ko00220,ko00330,ko01100,ko01110,ko01130,ko01230,ko05146,map00220,map00330,map01100,map01110,map01130,map01230,map05146	M00029,M00133,M00134	R00551,R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
MMS3_k127_1772557_76	351160.LRC52	2.568e-32	129.0	COG0231@1|root,arCOG04277@2157|Archaea,2XX3E@28890|Euryarchaeota,2N9R5@224756|Methanomicrobia	224756|Methanomicrobia	J	Functions by promoting the formation of the first peptide bond	eif5a	-	-	ko:K03263	-	-	-	-	ko00000,ko03012	-	-	-	EFP_N,eIF-5a
MMS3_k127_1772557_63	273116.14325594	5.952e-52	197.0	COG0601@1|root,arCOG00751@2157|Archaea,2XTRU@28890|Euryarchaeota	28890|Euryarchaeota	P	ABC-type dipeptide oligopeptide nickel transport systems, permease components	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
MMS3_k127_1772557_25	714943.Mucpa_0861	9.207e-109	362.0	COG0863@1|root,COG0863@2|Bacteria,4NZ6D@976|Bacteroidetes	976|Bacteroidetes	L	Belongs to the N(4) N(6)-methyltransferase family	-	-	2.1.1.72	ko:K00571	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
MMS3_k127_1772557_44	273116.14324585	8.763e-71	247.0	COG0723@1|root,arCOG01720@2157|Archaea	2157|Archaea	C	PFAM Rieske 2Fe-2S domain	soxL	-	-	-	-	-	-	-	-	-	-	-	Rieske
MMS3_k127_1772557_21	273075.Ta1228	1.2e-130	436.0	COG1290@1|root,arCOG01721@2157|Archaea,2XVE0@28890|Euryarchaeota	28890|Euryarchaeota	C	COG1290 Cytochrome b subunit of the bc complex	petB2	-	-	ko:K15879	-	-	-	-	ko00000	-	-	-	Cytochrom_B_C,Cytochrom_B_N_2
MMS3_k127_1772557_91	999630.TUZN_2081	2.166e-14	82.0	COG1024@1|root,arCOG00239@2157|Archaea	2157|Archaea	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
MMS3_k127_1772557_56	263820.PTO0280	7.536e-59	212.0	COG1836@1|root,arCOG02245@2157|Archaea,2XTBR@28890|Euryarchaeota,241UU@183967|Thermoplasmata	183967|Thermoplasmata	S	Integral membrane protein DUF92	-	-	-	-	-	-	-	-	-	-	-	-	DUF92
MMS3_k127_1772557_16	273116.14325265	1.355e-142	459.0	COG0214@1|root,arCOG04075@2157|Archaea,2XSYK@28890|Euryarchaeota,241JV@183967|Thermoplasmata	183967|Thermoplasmata	H	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively	pdxS	-	4.3.3.6	ko:K06215	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SOR_SNZ,ThiG
MMS3_k127_1772557_26	273116.14325418	7.391e-108	359.0	COG0730@1|root,arCOG02050@2157|Archaea,2XYUE@28890|Euryarchaeota,241RV@183967|Thermoplasmata	183967|Thermoplasmata	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
MMS3_k127_1772557_88	263820.PTO1247	4.523e-17	85.0	COG4272@1|root,arCOG05396@2157|Archaea,2Y4XV@28890|Euryarchaeota,242DN@183967|Thermoplasmata	183967|Thermoplasmata	S	Protein of unknown function (DUF1634)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1634
MMS3_k127_1772557_29	743719.PaelaDRAFT_1328	4.41e-104	344.0	COG1028@1|root,COG1028@2|Bacteria,1VREU@1239|Firmicutes,4HUY2@91061|Bacilli,26WDM@186822|Paenibacillaceae	91061|Bacilli	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
MMS3_k127_1772557_23	263820.PTO0477	5.644e-124	407.0	COG0626@1|root,arCOG00060@2157|Archaea,2XWWT@28890|Euryarchaeota,241ZJ@183967|Thermoplasmata	183967|Thermoplasmata	E	Cys/Met metabolism PLP-dependent enzyme	-	-	2.5.1.48	ko:K01739	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00999,R01288,R02508,R03217,R03260,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00420,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
MMS3_k127_1772557_54	671065.MetMK1DRAFT_00011870	3.351e-60	219.0	COG0083@1|root,arCOG01027@2157|Archaea,2XQN1@28889|Crenarchaeota	28889|Crenarchaeota	E	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate	thrB	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004413,GO:0006082,GO:0006520,GO:0006555,GO:0006566,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009088,GO:0009092,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019202,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.1.39	ko:K00872	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
MMS3_k127_1772557_72	1500281.JQKZ01000021_gene2675	1.451e-36	154.0	COG0460@1|root,COG0527@1|root,COG0460@2|Bacteria,COG0527@2|Bacteria,4NFGR@976|Bacteroidetes,1HX7S@117743|Flavobacteriia,3ZR0E@59732|Chryseobacterium	976|Bacteroidetes	E	Homoserine dehydrogenase	thrA	-	1.1.1.3,2.7.2.4	ko:K12524	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00017,M00018,M00526,M00527	R00480,R01773,R01775	RC00002,RC00043,RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7,Homoserine_dh,NAD_binding_3
MMS3_k127_1772557_34	589924.Ferp_1128	7.319e-89	304.0	COG0136@1|root,arCOG00494@2157|Archaea,2XTKH@28890|Euryarchaeota,245UR@183980|Archaeoglobi	183980|Archaeoglobi	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
MMS3_k127_1772557_84	671143.DAMO_2493	9.296e-23	100.0	COG2329@1|root,COG2329@2|Bacteria,2NS2V@2323|unclassified Bacteria	2|Bacteria	S	Evidence 4 Homologs of previously reported genes of	isdG	-	1.14.99.48,1.14.99.57	ko:K07145,ko:K21481	ko00860,ko01110,map00860,map01110	-	R10468,R10510	RC03185	ko00000,ko00001,ko01000	-	-	-	ABM
MMS3_k127_1772557_67	439481.Aboo_1462	8.733e-45	186.0	COG1572@1|root,COG4934@1|root,arCOG02532@2157|Archaea,arCOG03669@2157|Archaea,2Y7X2@28890|Euryarchaeota,3F35Y@33867|unclassified Euryarchaeota	28890|Euryarchaeota	O	Pro-kumamolisin, activation domain	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,CarboxypepD_reg,Pro-kuma_activ
MMS3_k127_1772557_60	273116.14324434	1.119e-54	207.0	COG0477@1|root,arCOG00132@2157|Archaea,2XW9U@28890|Euryarchaeota	28890|Euryarchaeota	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like,MFS_3
MMS3_k127_1772557_82	273116.14325399	2.591e-25	107.0	COG1644@1|root,arCOG04244@2157|Archaea,2Y03I@28890|Euryarchaeota,241XF@183967|Thermoplasmata	183967|Thermoplasmata	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoN	-	2.7.7.6	ko:K03058	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_N
MMS3_k127_1772557_65	273116.14325398	5.954e-49	177.0	COG0088@1|root,arCOG04243@2157|Archaea,2XWK0@28890|Euryarchaeota,241SC@183967|Thermoplasmata	183967|Thermoplasmata	J	Belongs to the universal ribosomal protein uS9 family	rps9	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
MMS3_k127_1772557_66	263820.PTO0323	5.932e-46	169.0	COG0102@1|root,arCOG04242@2157|Archaea,2XWN6@28890|Euryarchaeota,241TR@183967|Thermoplasmata	183967|Thermoplasmata	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rpl13	-	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
MMS3_k127_1772557_74	273116.14325396	1.145e-34	136.0	COG1727@1|root,arCOG00780@2157|Archaea,2XZ6R@28890|Euryarchaeota,241WH@183967|Thermoplasmata	183967|Thermoplasmata	J	Belongs to the eukaryotic ribosomal protein eL18 family	rpl18e	-	-	ko:K02883	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18
MMS3_k127_1772557_50	273116.14324793	1.073e-62	225.0	COG0565@1|root,arCOG01018@2157|Archaea,2XUIY@28890|Euryarchaeota,241SK@183967|Thermoplasmata	183967|Thermoplasmata	J	SpoU rRNA Methylase family	-	-	-	-	-	-	-	-	-	-	-	-	SpoU_methylase
MMS3_k127_1772557_46	273116.14324792	5.11e-67	238.0	COG1047@1|root,arCOG00980@2157|Archaea,2XTB7@28890|Euryarchaeota,241ST@183967|Thermoplasmata	183967|Thermoplasmata	O	Peptidyl-prolyl cis-trans	-	-	5.2.1.8	ko:K01802,ko:K03775	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C
MMS3_k127_1772557_5	263820.PTO0332	4.417e-221	694.0	COG1012@1|root,arCOG01252@2157|Archaea,2XT1Y@28890|Euryarchaeota,24237@183967|Thermoplasmata	183967|Thermoplasmata	C	NADP-dependent dehydrogenase of the nED (non- phosphorylated Entner-Doudoroff) pathway with highest activity towards glyceraldehydes (e.g. D,L-glyceraldehyde and D- glyceraldehyde), to a lesser extent towards D,L-glyceraldehyde-3- phosphate and glycolaldehyde, but no activity towards aliphatic or aromatic aldehydes	-	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005975,GO:0006081,GO:0006082,GO:0006090,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009056,GO:0009255,GO:0009987,GO:0016043,GO:0016052,GO:0016491,GO:0016620,GO:0016903,GO:0019637,GO:0019682,GO:0019752,GO:0022607,GO:0032787,GO:0042802,GO:0042803,GO:0043436,GO:0043796,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0046983,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0061678,GO:0065003,GO:0071704,GO:0071840,GO:1901135,GO:1901575	1.2.1.89	ko:K18128	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R10615	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
MMS3_k127_1772557_15	263820.PTO0336	1.641e-144	476.0	COG0469@1|root,arCOG04120@2157|Archaea,2XU34@28890|Euryarchaeota,24224@183967|Thermoplasmata	183967|Thermoplasmata	F	Pyruvate kinase, barrel domain	-	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
MMS3_k127_1772557_33	263820.PTO0339	5.677e-90	305.0	COG2876@1|root,arCOG01049@2157|Archaea,2XWR8@28890|Euryarchaeota,2426P@183967|Thermoplasmata	183967|Thermoplasmata	E	DAHP synthetase I family	-	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
MMS3_k127_1772557_64	263820.PTO0340	2.496e-49	184.0	COG0134@1|root,arCOG01088@2157|Archaea,2XTWK@28890|Euryarchaeota,241XE@183967|Thermoplasmata	183967|Thermoplasmata	E	indole-3-glycerol-phosphate synthase activity	trpC	-	4.1.1.48	ko:K01609	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508	RC00944	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS
MMS3_k127_1772557_73	1118235.CAJH01000043_gene2759	7.34e-35	139.0	COG0512@1|root,COG0512@2|Bacteria,1MV5Y@1224|Proteobacteria,1RMQW@1236|Gammaproteobacteria,1X41Q@135614|Xanthomonadales	135614|Xanthomonadales	EH	with TrpE catalyzes the formation of anthranilate and glutamate from chorismate and glutamine	trpG	-	4.1.3.27	ko:K01658	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
MMS3_k127_1772557_43	263820.PTO0342	2.599e-72	258.0	COG0147@1|root,arCOG02014@2157|Archaea,2XU5J@28890|Euryarchaeota,241T2@183967|Thermoplasmata	183967|Thermoplasmata	E	chorismate binding enzyme	-	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_bind
MMS3_k127_1772557_83	263820.PTO0343	1.029e-23	108.0	COG0135@1|root,arCOG01983@2157|Archaea,2Y7BT@28890|Euryarchaeota,242BQ@183967|Thermoplasmata	183967|Thermoplasmata	E	N-(5'phosphoribosyl)anthranilate (PRA) isomerase	trpF	-	5.3.1.24	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03509	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	PRAI
MMS3_k127_1772557_42	263820.PTO0344	3.475e-74	261.0	COG0547@1|root,arCOG02012@2157|Archaea,2XT3C@28890|Euryarchaeota,241QR@183967|Thermoplasmata	183967|Thermoplasmata	E	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	-	2.4.2.18	ko:K00766	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R01073	RC00440	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
MMS3_k127_1772557_53	263820.PTO0345	8.575e-61	218.0	COG0159@1|root,arCOG01086@2157|Archaea,2Y7BP@28890|Euryarchaeota,242D7@183967|Thermoplasmata	183967|Thermoplasmata	E	Tryptophan synthase alpha chain	-	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
MMS3_k127_1772557_9	263820.PTO0346	5.115e-183	580.0	COG1350@1|root,arCOG01432@2157|Archaea,2Y845@28890|Euryarchaeota,241KU@183967|Thermoplasmata	183967|Thermoplasmata	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	-	-	4.2.1.20	ko:K01696,ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
MMS3_k127_1772557_49	273116.14325297	1.208e-63	225.0	COG2226@1|root,arCOG04348@2157|Archaea,2Y6PI@28890|Euryarchaeota,242CN@183967|Thermoplasmata	183967|Thermoplasmata	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)	menG	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
MMS3_k127_1772557_79	273116.14325298	2.713e-28	117.0	COG2412@1|root,arCOG04051@2157|Archaea,2XYQK@28890|Euryarchaeota,241X0@183967|Thermoplasmata	183967|Thermoplasmata	S	Protein of unknown function (DUF424)	-	-	-	ko:K09148	-	-	-	-	ko00000	-	-	-	DUF424
MMS3_k127_1772557_2	273116.14325299	5.148e-241	763.0	COG1241@1|root,arCOG00439@2157|Archaea,2XT5D@28890|Euryarchaeota,241KG@183967|Thermoplasmata	183967|Thermoplasmata	L	MCM OB domain	-	-	-	ko:K10726	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	MCM,MCM_OB
MMS3_k127_1772557_20	273075.Ta0413	1.088e-131	432.0	COG3635@1|root,arCOG01696@2157|Archaea,2XTE8@28890|Euryarchaeota	28890|Euryarchaeota	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	apgM	-	5.4.2.12	ko:K15635	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,PhosphMutase
MMS3_k127_1772557_80	273116.14325422	2.739e-28	122.0	arCOG03853@1|root,arCOG03853@2157|Archaea,2Y52X@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_1772557_10	273075.Ta0468	1.52e-179	572.0	COG0172@1|root,arCOG00403@2157|Archaea,2XTGA@28890|Euryarchaeota,241N0@183967|Thermoplasmata	183967|Thermoplasmata	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
MMS3_k127_1772557_4	273075.Ta0414	7.526e-224	702.0	COG0493@1|root,arCOG01292@2157|Archaea,2XVPT@28890|Euryarchaeota	28890|Euryarchaeota	C	glutamate synthase	gltD	-	1.4.1.13,1.4.1.14,1.8.1.19	ko:K00266,ko:K20202	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
MMS3_k127_1772557_94	273116.14324579	6.633e-07	59.0	arCOG07408@1|root,arCOG07408@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_1772557_85	273075.Ta0305	1.22e-22	100.0	arCOG06958@1|root,arCOG06958@2157|Archaea,2Y0YB@28890|Euryarchaeota,242CP@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_1772557_77	263820.PTO0450	1.178e-30	123.0	COG1849@1|root,arCOG01224@2157|Archaea,2XYS0@28890|Euryarchaeota,241T6@183967|Thermoplasmata	183967|Thermoplasmata	S	Protein of unknown function (DUF357)	-	-	-	ko:K09728	-	-	-	-	ko00000	-	-	-	DUF357
MMS3_k127_1772557_59	273116.14324776	3.411e-56	200.0	COG0099@1|root,arCOG01722@2157|Archaea,2XWHE@28890|Euryarchaeota,241SD@183967|Thermoplasmata	183967|Thermoplasmata	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rps13	-	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
MMS3_k127_1772557_48	263820.PTO1220	1.7e-65	229.0	COG0522@1|root,arCOG04239@2157|Archaea,2XXYX@28890|Euryarchaeota,241PV@183967|Thermoplasmata	183967|Thermoplasmata	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rps4	-	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
MMS3_k127_1772557_47	263820.PTO1221	6.308e-67	229.0	COG0100@1|root,arCOG04240@2157|Archaea,2XX1S@28890|Euryarchaeota,241PM@183967|Thermoplasmata	183967|Thermoplasmata	J	Located on the platform of the 30S subunit	rps11	-	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
MMS3_k127_1772557_27	273075.Ta1030	4.715e-106	350.0	COG0202@1|root,arCOG04241@2157|Archaea,2XTQB@28890|Euryarchaeota,241P6@183967|Thermoplasmata	183967|Thermoplasmata	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoD	-	2.7.7.6	ko:K03047	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_A_bac,RNA_pol_L
MMS3_k127_1772557_70	439481.Aboo_0079	1.17e-38	154.0	COG0483@1|root,arCOG01349@2157|Archaea,2Y87S@28890|Euryarchaeota,3F2MR@33867|unclassified Euryarchaeota	28890|Euryarchaeota	G	Inositol monophosphatase family	-	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
MMS3_k127_1772557_31	273075.Ta0622	2.531e-98	328.0	COG0061@1|root,arCOG01348@2157|Archaea,2XTP6@28890|Euryarchaeota,241Q7@183967|Thermoplasmata	183967|Thermoplasmata	F	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
MMS3_k127_1772557_68	263820.PTO0192	6.674e-44	162.0	COG1310@1|root,arCOG01139@2157|Archaea,2XWKU@28890|Euryarchaeota,241V3@183967|Thermoplasmata	183967|Thermoplasmata	S	metal-dependent protease of the PAD1 JAB1 superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Prok-JAB
MMS3_k127_1772557_30	273116.14324587	2.988e-99	332.0	COG2513@1|root,arCOG00581@2157|Archaea,2Y86J@28890|Euryarchaeota,241XC@183967|Thermoplasmata	183967|Thermoplasmata	G	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate	-	-	4.1.3.30,5.4.2.9	ko:K01841,ko:K03417	ko00440,ko00640,ko01100,ko01120,ko01130,map00440,map00640,map01100,map01120,map01130	-	R00409,R00661	RC00286,RC00287,RC02792	ko00000,ko00001,ko01000	-	-	-	PEP_mutase
MMS3_k127_1772557_17	273116.14324588	3.307e-142	465.0	COG2079@1|root,arCOG04285@2157|Archaea,2XTMT@28890|Euryarchaeota,2426I@183967|Thermoplasmata	183967|Thermoplasmata	S	MmgE/PrpD family	-	-	4.2.1.79	ko:K01720	ko00640,map00640	-	R04424	RC01152	ko00000,ko00001,ko01000	-	-	-	MmgE_PrpD
MMS3_k127_1772557_86	1173027.Mic7113_1234	4.704e-20	102.0	COG1808@1|root,COG1808@2|Bacteria,1GCGN@1117|Cyanobacteria	1117|Cyanobacteria	S	Domain of unknown function (DUF389)	-	-	-	-	-	-	-	-	-	-	-	-	DUF389
MMS3_k127_1772557_69	386456.JQKN01000002_gene2764	3.923e-42	160.0	COG3476@1|root,arCOG04434@2157|Archaea,2XYQD@28890|Euryarchaeota	28890|Euryarchaeota	T	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)	tspO	GO:0003674,GO:0005488,GO:0005575,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016021,GO:0031224,GO:0033013,GO:0044237,GO:0044425,GO:0046483,GO:0046906,GO:0071704,GO:0097159,GO:1901360,GO:1901363,GO:1901564	-	ko:K05770	ko04080,ko04214,ko04979,ko05166,map04080,map04214,map04979,map05166	-	-	-	ko00000,ko00001,ko02000	9.A.24	-	-	TspO_MBR
MMS3_k127_1774954_9	273063.STK_12180	6.283e-21	96.0	COG0111@1|root,arCOG01754@2157|Archaea,2XPRE@28889|Crenarchaeota	28889|Crenarchaeota	C	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
MMS3_k127_1774954_4	273116.14325205	2.121e-69	245.0	COG1131@1|root,arCOG00194@2157|Archaea,2XUG5@28890|Euryarchaeota,241YW@183967|Thermoplasmata	183967|Thermoplasmata	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
MMS3_k127_1774954_6	263820.PTO1498	9.11e-64	228.0	COG1277@1|root,arCOG03690@2157|Archaea,2Y1XM@28890|Euryarchaeota,2427A@183967|Thermoplasmata	183967|Thermoplasmata	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
MMS3_k127_1774954_10	273075.Ta0855	3.378e-10	70.0	arCOG06977@1|root,arCOG06977@2157|Archaea,2Y5JA@28890|Euryarchaeota,242FY@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_1774954_8	263820.PTO1264	3.649e-38	155.0	COG0463@1|root,arCOG05398@2157|Archaea,2Y50K@28890|Euryarchaeota,242DT@183967|Thermoplasmata	183967|Thermoplasmata	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_1774954_12	273116.14324453	6.833e-06	60.0	arCOG03675@1|root,arCOG06052@1|root,arCOG03675@2157|Archaea,arCOG06052@2157|Archaea	2157|Archaea	S	Thermopsin	-	-	3.4.23.42	ko:K01385	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	CARDB,Thermopsin
MMS3_k127_1774954_7	273075.Ta0544	1.267e-50	184.0	COG0241@1|root,arCOG07384@2157|Archaea,2Y0DK@28890|Euryarchaeota,242CA@183967|Thermoplasmata	183967|Thermoplasmata	E	Converts the D-glycero-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-D-manno-heptose 1-phosphate by removing the phosphate group at the C-7 position	gmhB	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0034200,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914	3.1.3.82,3.1.3.83	ko:K03273	ko00540,ko01100,map00540,map01100	M00064	R05647,R09771	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	PNK3P
MMS3_k127_1774954_1	273075.Ta0143	5.84e-112	370.0	COG3839@1|root,arCOG00175@2157|Archaea,2Y7MB@28890|Euryarchaeota,24216@183967|Thermoplasmata	183967|Thermoplasmata	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K17314	ko02010,map02010	M00604	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.15	-	-	ABC_tran
MMS3_k127_1774954_2	273075.Ta0147	1.555e-107	362.0	COG3408@1|root,arCOG03287@2157|Archaea,2XU8W@28890|Euryarchaeota	28890|Euryarchaeota	G	N-terminal domain of (some) glycogen debranching enzymes	-	-	-	-	-	-	-	-	-	-	-	-	GDE_C,GDE_N_bis
MMS3_k127_1774954_5	273075.Ta0146	1.61e-65	233.0	COG0395@1|root,arCOG00159@2157|Archaea,2Y3NJ@28890|Euryarchaeota,2428H@183967|Thermoplasmata	183967|Thermoplasmata	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K17313	ko02010,map02010	M00604	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.15	-	-	BPD_transp_1
MMS3_k127_1774954_11	351160.RCIX612	1.369e-09	70.0	COG1293@1|root,arCOG01695@2157|Archaea,2XTMF@28890|Euryarchaeota,2N97T@224756|Methanomicrobia	224756|Methanomicrobia	K	Domain of unknown function (DUF814)	-	-	-	-	-	-	-	-	-	-	-	-	DUF814,FbpA
MMS3_k127_1774954_3	273075.Ta0145	1.664e-73	265.0	COG1175@1|root,arCOG00157@2157|Archaea,2XU7E@28890|Euryarchaeota,2427U@183967|Thermoplasmata	183967|Thermoplasmata	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K17312	ko02010,map02010	M00604	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.15	-	-	BPD_transp_1
MMS3_k127_1774954_0	273075.Ta0144	1.685e-162	526.0	COG1653@1|root,arCOG00153@2157|Archaea,2Y3M5@28890|Euryarchaeota,24281@183967|Thermoplasmata	183967|Thermoplasmata	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K17311	ko02010,map02010	M00604	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.15	-	-	SBP_bac_1
MMS3_k127_1801236_18	1417296.U879_03690	8.705e-106	355.0	COG1145@1|root,COG1456@1|root,COG1145@2|Bacteria,COG1456@2|Bacteria,1R6BH@1224|Proteobacteria,2USUR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	CO dehydrogenase/acetyl-CoA synthase delta subunit	-	-	-	-	-	-	-	-	-	-	-	-	CdhD,Fer4
MMS3_k127_1801236_27	1417296.U879_03685	1.624e-61	219.0	COG0500@1|root,COG2226@2|Bacteria,1R41W@1224|Proteobacteria,2UJDA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Mycolic acid cyclopropane synthetase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
MMS3_k127_1801236_16	351160.RCIX1093	8.57e-116	381.0	COG1073@1|root,arCOG01661@2157|Archaea,2XVIC@28890|Euryarchaeota,2NANZ@224756|Methanomicrobia	224756|Methanomicrobia	S	Alpha/beta hydrolase family	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Peptidase_S9
MMS3_k127_1801236_26	263820.PTO0094	1.202e-68	238.0	COG3371@1|root,arCOG02008@2157|Archaea,2Y10K@28890|Euryarchaeota,2428W@183967|Thermoplasmata	183967|Thermoplasmata	S	Protein of unknown function (DUF998)	-	-	-	-	-	-	-	-	-	-	-	-	DUF998
MMS3_k127_1801236_51	673860.AciM339_1043	2.359e-08	65.0	arCOG11292@1|root,arCOG11292@2157|Archaea,2Y3FT@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_1801236_14	273063.STK_19010	9.927e-127	417.0	COG1914@1|root,arCOG04531@2157|Archaea,2XRNF@28889|Crenarchaeota	28889|Crenarchaeota	P	Natural resistance-associated macrophage protein	-	-	-	-	-	-	-	-	-	-	-	-	Nramp
MMS3_k127_1801236_34	263820.PTO1076	9.304e-44	169.0	COG0338@1|root,arCOG03416@2157|Archaea,2XWJX@28890|Euryarchaeota	28890|Euryarchaeota	L	D12 class N6 adenine-specific DNA methyltransferase	-	-	2.1.1.72	ko:K06223	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko02048,ko03032,ko03400	-	-	-	MethyltransfD12
MMS3_k127_1801236_37	485913.Krac_1995	2.693e-39	150.0	COG5649@1|root,COG5649@2|Bacteria	2|Bacteria	E	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
MMS3_k127_1801236_33	525904.Tter_2394	6.505e-47	172.0	COG5646@1|root,COG5646@2|Bacteria,2NQX2@2323|unclassified Bacteria	2|Bacteria	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
MMS3_k127_1801236_24	1174528.JH992898_gene3564	3.557e-74	258.0	COG0350@1|root,COG2169@1|root,COG0350@2|Bacteria,COG2169@2|Bacteria,1G0MX@1117|Cyanobacteria,1JIE9@1189|Stigonemataceae	1117|Cyanobacteria	FL	Metal binding domain of Ada	-	-	2.1.1.63	ko:K00567,ko:K10778	-	-	-	-	ko00000,ko01000,ko03000,ko03400	-	-	-	Ada_Zn_binding,DNA_binding_1,HTH_18,Methyltransf_1N
MMS3_k127_1801236_45	933801.Ahos_0164	2.66e-18	100.0	COG3391@1|root,arCOG06052@1|root,arCOG02560@2157|Archaea,arCOG06052@2157|Archaea,2XRYP@28889|Crenarchaeota	28889|Crenarchaeota	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_1801236_48	88036.EFJ35899	3.275e-13	80.0	KOG0088@1|root,KOG0088@2759|Eukaryota,37P4T@33090|Viridiplantae,3GFRE@35493|Streptophyta	35493|Streptophyta	U	Ras family	-	-	-	ko:K07890	-	-	-	-	ko00000,ko04031,ko04131,ko04147	-	-	-	Ras
MMS3_k127_1801236_7	273063.STK_17010	1.13e-178	582.0	COG0348@1|root,arCOG03696@2157|Archaea	2157|Archaea	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
MMS3_k127_1801236_44	263820.PTO1299	2.619e-27	122.0	COG0348@1|root,arCOG03696@2157|Archaea	2157|Archaea	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
MMS3_k127_1801236_40	479432.Sros_4058	3.242e-37	149.0	COG0596@1|root,COG0596@2|Bacteria,2HEMJ@201174|Actinobacteria,4EJ11@85012|Streptosporangiales	201174|Actinobacteria	Q	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
MMS3_k127_1801236_41	1041930.Mtc_1209	1.224e-32	131.0	COG0393@1|root,arCOG02287@2157|Archaea,2XYRF@28890|Euryarchaeota,2NAUZ@224756|Methanomicrobia	224756|Methanomicrobia	S	Putative heavy-metal-binding	-	-	-	-	-	-	-	-	-	-	-	-	YbjQ_1
MMS3_k127_1801236_9	933801.Ahos_0953	3.709e-157	511.0	COG0591@1|root,arCOG01316@2157|Archaea,2XR75@28889|Crenarchaeota	28889|Crenarchaeota	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
MMS3_k127_1801236_49	1056495.Calag_1111	4.347e-10	63.0	arCOG03694@1|root,arCOG03694@2157|Archaea,2XRJF@28889|Crenarchaeota	28889|Crenarchaeota	S	Protein of unknown function (DUF3311)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3311
MMS3_k127_1801236_11	263820.PTO0815	2.465e-147	481.0	arCOG00144@1|root,arCOG00144@2157|Archaea,2Y6AX@28890|Euryarchaeota,242CM@183967|Thermoplasmata	183967|Thermoplasmata	G	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS3_k127_1801236_4	273116.14324302	1.001e-222	703.0	COG2759@1|root,arCOG04541@2157|Archaea,2XUXB@28890|Euryarchaeota,241K6@183967|Thermoplasmata	183967|Thermoplasmata	F	formate-tetrahydrofolate ligase activity	fhs	-	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
MMS3_k127_1801236_36	877455.Metbo_0667	1.573e-40	159.0	COG1014@1|root,arCOG01602@2157|Archaea,2XXK2@28890|Euryarchaeota,23PCK@183925|Methanobacteria	183925|Methanobacteria	C	indolepyruvate ferredoxin oxidoreductase, beta subunit	iorB	-	1.2.7.8	ko:K00180	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR
MMS3_k127_1801236_6	673860.AciM339_0762	1.947e-187	604.0	COG4231@1|root,arCOG01609@2157|Archaea,2XUNR@28890|Euryarchaeota,3F2HQ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	iorA	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,Fer4_7,POR_N,TPP_enzyme_C
MMS3_k127_1801236_35	673860.AciM339_0745	4.874e-42	162.0	COG1042@1|root,arCOG01338@2157|Archaea,2Y39C@28890|Euryarchaeota,3F35C@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	ATP-grasp domain	-	-	6.2.1.13	ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5
MMS3_k127_1801236_15	439481.Aboo_0319	4.831e-118	394.0	COG1042@1|root,arCOG01340@2157|Archaea,2XT9G@28890|Euryarchaeota,3F326@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	CoA binding domain	acdA	-	6.2.1.13	ko:K01905	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	CoA_binding_2,Succ_CoA_lig
MMS3_k127_1801236_50	273075.Ta0012	5.99e-09	60.0	arCOG07353@1|root,arCOG07353@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_1801236_19	263820.PTO0620	1.25e-98	328.0	COG1100@1|root,arCOG01225@2157|Archaea,2XWN4@28890|Euryarchaeota,241NA@183967|Thermoplasmata	183967|Thermoplasmata	S	Conserved hypothetical ATP binding protein	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	ATP_bind_1
MMS3_k127_1801236_0	273075.Ta0036m	0.0	1326.0	COG1933@1|root,arCOG04447@2157|Archaea,2XU5S@28890|Euryarchaeota,241KH@183967|Thermoplasmata	183967|Thermoplasmata	L	Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase	polC	-	2.7.7.7	ko:K02322	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	M00264	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	PolC_DP2
MMS3_k127_1801236_43	273116.14324248	6.116e-28	115.0	COG3255@1|root,arCOG01843@2157|Archaea,2Y0F9@28890|Euryarchaeota,241WX@183967|Thermoplasmata	183967|Thermoplasmata	I	SCP-2 sterol transfer family	-	-	-	-	-	-	-	-	-	-	-	-	SCP2
MMS3_k127_1801236_5	673860.AciM339_0284	2.542e-206	655.0	COG0504@1|root,arCOG00063@2157|Archaea,2XTR2@28890|Euryarchaeota,3F2HU@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
MMS3_k127_1801236_32	273116.14324289	1.244e-47	176.0	COG2042@1|root,arCOG04733@2157|Archaea,2XVBD@28890|Euryarchaeota,241V7@183967|Thermoplasmata	183967|Thermoplasmata	J	pre-rRNA processing protein involved in ribosome biogenesis	-	-	-	ko:K09140	-	-	-	-	ko00000,ko03009	-	-	-	RLI,Ribo_biogen_C
MMS3_k127_1801236_12	273116.14324286	3.669e-144	471.0	arCOG05346@1|root,arCOG05346@2157|Archaea,2XWG1@28890|Euryarchaeota,241ZP@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_1801236_13	263820.PTO0563	4.046e-130	424.0	COG3367@1|root,arCOG02828@2157|Archaea,2XTPS@28890|Euryarchaeota,24244@183967|Thermoplasmata	183967|Thermoplasmata	S	Domain of unknown function (DUF1611_N) Rossmann-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF1611,DUF1611_N
MMS3_k127_1801236_20	263820.PTO0564	2.16e-92	314.0	COG0498@1|root,arCOG01434@2157|Archaea,2XT84@28890|Euryarchaeota,2424F@183967|Thermoplasmata	183967|Thermoplasmata	E	Pyridoxal-phosphate dependent enzyme	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
MMS3_k127_1801236_25	273075.Ta0022	3.388e-69	245.0	COG1650@1|root,arCOG01616@2157|Archaea,2XUM0@28890|Euryarchaeota,241QQ@183967|Thermoplasmata	183967|Thermoplasmata	J	D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo	dtdA	-	3.1.1.96	ko:K09716	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_deacylase
MMS3_k127_1801236_2	273075.Ta0040	5.179e-254	805.0	COG0525@1|root,arCOG00808@2157|Archaea,2XSXQ@28890|Euryarchaeota,241KT@183967|Thermoplasmata	183967|Thermoplasmata	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
MMS3_k127_1801236_3	273116.14325577	8.525e-234	738.0	COG3387@1|root,arCOG03286@2157|Archaea,2XUKJ@28890|Euryarchaeota,2421E@183967|Thermoplasmata	183967|Thermoplasmata	G	Glycosyl hydrolases family 15	-	-	3.2.1.3	ko:K01178	ko00500,ko01100,map00500,map01100	-	R01790,R01791,R06199	-	ko00000,ko00001,ko01000	-	GH15	-	Glyco_hydro_15
MMS3_k127_1801236_28	273075.Ta0285	4.847e-60	221.0	COG0337@1|root,arCOG00983@2157|Archaea,2XY3B@28890|Euryarchaeota,2427G@183967|Thermoplasmata	183967|Thermoplasmata	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	4.2.3.4	ko:K01735	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03083	RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase
MMS3_k127_1801236_42	572546.Arcpr_0877	5.721e-29	126.0	COG0169@1|root,arCOG01033@2157|Archaea,2XV7K@28890|Euryarchaeota,2464B@183980|Archaeoglobi	183980|Archaeoglobi	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	-	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_DH,Shikimate_dh_N
MMS3_k127_1801236_30	263820.PTO0601	5.321e-53	196.0	COG1685@1|root,arCOG01025@2157|Archaea,2XUI2@28890|Euryarchaeota,241WG@183967|Thermoplasmata	183967|Thermoplasmata	E	GHMP kinases N terminal domain	aroK	-	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_N
MMS3_k127_1801236_23	263820.PTO0602	9.162e-76	269.0	COG0128@1|root,arCOG04134@2157|Archaea,2XTC3@28890|Euryarchaeota,241VD@183967|Thermoplasmata	183967|Thermoplasmata	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
MMS3_k127_1801236_10	263820.PTO0603	2.625e-152	499.0	COG0018@1|root,arCOG00487@2157|Archaea,2XTWP@28890|Euryarchaeota,241MK@183967|Thermoplasmata	183967|Thermoplasmata	J	DALR anticodon binding domain	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	DALR_1,tRNA-synt_1d
MMS3_k127_1801236_39	273116.14324887	1.568e-37	143.0	COG0393@1|root,arCOG02287@2157|Archaea,2XYRF@28890|Euryarchaeota,2429W@183967|Thermoplasmata	183967|Thermoplasmata	S	Putative heavy-metal-binding	-	-	-	-	-	-	-	-	-	-	-	-	YbjQ_1
MMS3_k127_1801236_8	273116.14325006	4.947e-178	572.0	COG0661@1|root,arCOG01189@2157|Archaea,2XT2I@28890|Euryarchaeota,24200@183967|Thermoplasmata	183967|Thermoplasmata	S	ABC1 family	-	-	-	-	-	-	-	-	-	-	-	-	ABC1
MMS3_k127_1801236_38	263820.PTO0739	3.561e-39	149.0	COG0071@1|root,arCOG01832@2157|Archaea,2Y7BQ@28890|Euryarchaeota,242D8@183967|Thermoplasmata	183967|Thermoplasmata	O	Hsp20/alpha crystallin family	-	-	-	-	-	-	-	-	-	-	-	-	HSP20
MMS3_k127_1801236_22	273116.14325004	1.666e-87	301.0	COG1703@1|root,arCOG01226@2157|Archaea,2XUHG@28890|Euryarchaeota,2421X@183967|Thermoplasmata	183967|Thermoplasmata	E	ArgK protein	-	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK
MMS3_k127_1801236_31	1459636.NTE_01111	1.345e-48	177.0	COG2185@1|root,arCOG01710@2157|Archaea,41SJN@651137|Thaumarchaeota	651137|Thaumarchaeota	I	B12 binding domain	-	-	5.4.99.2	ko:K01849	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding
MMS3_k127_1801236_1	273116.14325002	3.242e-290	899.0	COG1884@1|root,arCOG04232@2157|Archaea,2XU3F@28890|Euryarchaeota,24230@183967|Thermoplasmata	183967|Thermoplasmata	I	Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
MMS3_k127_1801236_21	673860.AciM339_0524	3.877e-91	307.0	COG0463@1|root,arCOG01385@2157|Archaea,2XUEP@28890|Euryarchaeota,3F30S@33867|unclassified Euryarchaeota	28890|Euryarchaeota	M	PFAM Glycosyl transferase family 2	aglI	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
MMS3_k127_1801236_46	273075.Ta1047a	3.031e-17	85.0	arCOG05330@1|root,arCOG05330@2157|Archaea,2Y24Y@28890|Euryarchaeota,242GS@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_1801236_47	263820.PTO0266	3.368e-17	89.0	COG1711@1|root,arCOG00551@2157|Archaea,2Y7CG@28890|Euryarchaeota,242DH@183967|Thermoplasmata	183967|Thermoplasmata	L	protein conserved in archaea	-	-	-	ko:K09723	-	-	-	-	ko00000,ko03032	-	-	-	-
MMS3_k127_1801236_29	263820.PTO0265	4.817e-59	216.0	COG1831@1|root,arCOG00893@2157|Archaea,2XTX7@28890|Euryarchaeota,241VE@183967|Thermoplasmata	183967|Thermoplasmata	S	TatD related DNase	-	-	-	ko:K07049	-	-	-	-	ko00000	-	-	-	TatD_DNase
MMS3_k127_1801236_17	273116.14324522	6.422e-112	364.0	COG0638@1|root,arCOG00971@2157|Archaea,2XUKA@28890|Euryarchaeota,241MX@183967|Thermoplasmata	183967|Thermoplasmata	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	psmA	GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0019538,GO:0019773,GO:0030163,GO:0032991,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03432	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome,Proteasome_A_N
MMS3_k127_1828597_64	644968.DFW101_2954	7.863e-13	71.0	COG3464@1|root,COG3464@2|Bacteria,1MV5J@1224|Proteobacteria,42M93@68525|delta/epsilon subdivisions,2WK5I@28221|Deltaproteobacteria,2M9GS@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	PFAM Transposase, IS204 IS1001 IS1096 IS1165	-	-	-	ko:K07485	-	-	-	-	ko00000	-	-	-	DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3
MMS3_k127_1828597_63	673860.AciM339_1207	2.328e-13	72.0	COG1873@1|root,arCOG02155@2157|Archaea,2Y75G@28890|Euryarchaeota,3F3FD@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	PRC-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	PRC
MMS3_k127_1828597_5	273116.14324803	1.117e-179	571.0	COG1503@1|root,arCOG01742@2157|Archaea,2XSV5@28890|Euryarchaeota,241JX@183967|Thermoplasmata	183967|Thermoplasmata	J	Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA	prf1	-	-	ko:K03265	ko03015,map03015	-	-	-	ko00000,ko00001,ko03012,ko03019	-	-	-	eRF1_1,eRF1_2,eRF1_3
MMS3_k127_1828597_33	263820.PTO1444	3.958e-65	229.0	COG0528@1|root,arCOG00858@2157|Archaea,2XT3U@28890|Euryarchaeota,241S5@183967|Thermoplasmata	183967|Thermoplasmata	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
MMS3_k127_1828597_0	273116.14325060	0.0	1140.0	COG0060@1|root,arCOG00807@2157|Archaea,2XTIX@28890|Euryarchaeota,241IC@183967|Thermoplasmata	183967|Thermoplasmata	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
MMS3_k127_1828597_26	273075.Ta0526	6.412e-86	295.0	COG0611@1|root,arCOG00638@2157|Archaea,2XSUK@28890|Euryarchaeota,241UZ@183967|Thermoplasmata	183967|Thermoplasmata	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
MMS3_k127_1828597_15	273116.14325271	4.687e-121	398.0	COG1244@1|root,arCOG01360@2157|Archaea,2XT5Q@28890|Euryarchaeota,241Q2@183967|Thermoplasmata	183967|Thermoplasmata	S	Elongator protein 3, MiaB family, Radical SAM	-	-	-	ko:K06936	-	-	-	-	ko00000	-	-	-	Radical_SAM
MMS3_k127_1828597_12	273075.Ta0529m	1.403e-133	436.0	COG0436@1|root,arCOG01130@2157|Archaea,2XSVT@28890|Euryarchaeota,241M6@183967|Thermoplasmata	183967|Thermoplasmata	E	Aminotransferase class I and II	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
MMS3_k127_1828597_20	273075.Ta0537m	1.156e-109	360.0	COG1407@1|root,arCOG01150@2157|Archaea,2XU3W@28890|Euryarchaeota,241SF@183967|Thermoplasmata	183967|Thermoplasmata	S	Calcineurin-like phosphoesterase	-	-	-	ko:K06953	-	-	-	-	ko00000	-	-	-	Metallophos
MMS3_k127_1828597_41	263820.PTO0918	1.859e-51	199.0	COG0373@1|root,arCOG01036@2157|Archaea,2XTTG@28890|Euryarchaeota,241SI@183967|Thermoplasmata	183967|Thermoplasmata	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	-	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
MMS3_k127_1828597_55	930945.SiRe_2083	1.057e-20	97.0	COG0494@1|root,arCOG01072@2157|Archaea,2XRJY@28889|Crenarchaeota	28889|Crenarchaeota	L	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
MMS3_k127_1828597_50	263820.PTO0755	1.555e-27	116.0	COG1661@1|root,arCOG04212@2157|Archaea,2Y7CU@28890|Euryarchaeota,242DU@183967|Thermoplasmata	183967|Thermoplasmata	S	Domain of unknown function (DUF296)	-	-	-	ko:K06934	-	-	-	-	ko00000	-	-	-	DUF296
MMS3_k127_1828597_13	263820.PTO1371	5.837e-131	428.0	COG3508@1|root,arCOG06976@2157|Archaea	2157|Archaea	C	homogentisate 1,2-dioxygenase	-	-	1.13.11.5	ko:K00451	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R02519	RC00737	ko00000,ko00001,ko00002,ko01000	-	-	-	HgmA
MMS3_k127_1828597_31	218284.CCDN010000002_gene2113	1.808e-68	243.0	COG0179@1|root,COG0179@2|Bacteria,1UY98@1239|Firmicutes,4HC89@91061|Bacilli,1ZCD1@1386|Bacillus	91061|Bacilli	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	3.7.1.2	ko:K16171	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R01364	RC00326,RC00446	ko00000,ko00001,ko00002,ko01000	-	-	-	FAA_hydrolase
MMS3_k127_1828597_16	1341151.ASZU01000004_gene347	6.852e-119	392.0	COG3185@1|root,COG3185@2|Bacteria,1UZP2@1239|Firmicutes,4HDQI@91061|Bacilli,27B5H@186824|Thermoactinomycetaceae	91061|Bacilli	E	Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal	hppD	-	1.13.11.27	ko:K00457	ko00130,ko00350,ko00360,ko01100,map00130,map00350,map00360,map01100	M00044	R01372,R02521	RC00505,RC00738	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Glyoxalase,Glyoxalase_5
MMS3_k127_1828597_37	263820.PTO0818	2.958e-55	201.0	COG3253@1|root,arCOG03031@2157|Archaea,2Y3V1@28890|Euryarchaeota,2427W@183967|Thermoplasmata	183967|Thermoplasmata	S	Chlorite dismutase	-	-	-	-	-	-	-	-	-	-	-	-	Chlor_dismutase
MMS3_k127_1828597_17	273075.Ta0506m	1.885e-117	393.0	COG0301@1|root,COG0607@1|root,arCOG00038@2157|Archaea,arCOG02021@2157|Archaea,2XUHM@28890|Euryarchaeota,241US@183967|Thermoplasmata	183967|Thermoplasmata	HP	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	thiI	-	2.8.1.4	ko:K03151	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07461	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Rhodanese,THUMP,ThiI
MMS3_k127_1828597_54	263820.PTO0688	1.425e-22	113.0	arCOG03691@1|root,arCOG03691@2157|Archaea,2Y1YV@28890|Euryarchaeota,242AJ@183967|Thermoplasmata	183967|Thermoplasmata	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_1828597_43	263820.PTO1506	8.303e-49	179.0	COG1611@1|root,arCOG02431@2157|Archaea,2XXTK@28890|Euryarchaeota,24289@183967|Thermoplasmata	183967|Thermoplasmata	S	Rossmann fold nucleotide-binding protein	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	-
MMS3_k127_1828597_36	1218108.KB908294_gene2118	1.092e-55	199.0	COG1443@1|root,COG1443@2|Bacteria,4NFJV@976|Bacteroidetes,1HXIQ@117743|Flavobacteriia	976|Bacteroidetes	I	Isopentenyl-diphosphate delta-isomerase	idi	-	5.3.3.2	ko:K01823	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00095,M00096,M00364,M00365,M00366,M00367	R01123	RC00455	ko00000,ko00001,ko00002,ko01000	-	-	-	NUDIX
MMS3_k127_1828597_58	1198232.CYCME_2222	5.351e-20	94.0	COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,1MURA@1224|Proteobacteria,1RN27@1236|Gammaproteobacteria,460KK@72273|Thiotrichales	72273|Thiotrichales	P	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
MMS3_k127_1828597_25	263820.PTO1442	1.676e-87	304.0	COG2379@1|root,arCOG04170@2157|Archaea,2XSTZ@28890|Euryarchaeota,2420W@183967|Thermoplasmata	183967|Thermoplasmata	G	MOFRL family	-	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016491,GO:0016661,GO:0016662,GO:0016740,GO:0016772,GO:0043798,GO:0044237,GO:0055114	2.7.1.165	ko:K11529	ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200	M00346	R08572	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4147,MOFRL
MMS3_k127_1828597_45	263820.PTO1341	9.727e-46	175.0	COG2519@1|root,arCOG00978@2157|Archaea,2XTV7@28890|Euryarchaeota,241UX@183967|Thermoplasmata	183967|Thermoplasmata	J	tRNA methyltransferase complex GCD14 subunit	-	-	2.1.1.219,2.1.1.220	ko:K07442	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	GCD14
MMS3_k127_1828597_30	263820.PTO0779	1.042e-73	262.0	COG0477@1|root,arCOG00130@2157|Archaea,2Y7AR@28890|Euryarchaeota,2426M@183967|Thermoplasmata	183967|Thermoplasmata	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS3_k127_1828597_22	273075.Ta0541	7.327e-104	351.0	COG0247@1|root,arCOG00333@2157|Archaea,2Y695@28890|Euryarchaeota,241ZB@183967|Thermoplasmata	183967|Thermoplasmata	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
MMS3_k127_1828597_8	263820.PTO1045	6.012e-156	504.0	COG0277@1|root,arCOG00337@2157|Archaea,2XT5C@28890|Euryarchaeota,241N2@183967|Thermoplasmata	183967|Thermoplasmata	C	FAD binding domain	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
MMS3_k127_1828597_2	263820.PTO1428	1.481e-208	685.0	COG2409@1|root,arCOG02175@2157|Archaea,2XVKJ@28890|Euryarchaeota,241Q8@183967|Thermoplasmata	183967|Thermoplasmata	S	MMPL family	-	-	-	ko:K06994	-	-	-	-	ko00000	-	-	-	MMPL
MMS3_k127_1828597_52	263820.PTO0200	1.375e-24	106.0	COG1522@1|root,arCOG01580@2157|Archaea	2157|Archaea	K	COG1522 Transcriptional regulators	asnC1	-	-	ko:K03718	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
MMS3_k127_1828597_48	273116.14324841	2.061e-33	132.0	COG1698@1|root,arCOG04308@2157|Archaea,2XZVX@28890|Euryarchaeota,241U7@183967|Thermoplasmata	183967|Thermoplasmata	S	Uncharacterised protein family (UPF0147)	-	-	-	ko:K09721	-	-	-	-	ko00000	-	-	-	UPF0147
MMS3_k127_1828597_38	263820.PTO0198	5.375e-54	191.0	COG4738@1|root,arCOG04377@2157|Archaea,2XZEC@28890|Euryarchaeota,2428A@183967|Thermoplasmata	183967|Thermoplasmata	K	Transcriptional regulator, TrmB	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_1828597_40	1408813.AYMG01000023_gene1994	5.844e-53	194.0	COG0120@1|root,COG0120@2|Bacteria,4NMB9@976|Bacteroidetes,1ISPR@117747|Sphingobacteriia	976|Bacteroidetes	G	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate	rpiA	-	5.3.1.6	ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167,M00580	R01056	RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	Rib_5-P_isom_A
MMS3_k127_1828597_42	273075.Ta0599	3.043e-51	186.0	COG1607@1|root,arCOG00773@2157|Archaea,2XXDM@28890|Euryarchaeota,24296@183967|Thermoplasmata	183967|Thermoplasmata	I	Thioesterase superfamily	-	-	3.1.2.20	ko:K01073	-	-	-	-	ko00000,ko01000	-	-	-	4HBT
MMS3_k127_1828597_57	273116.14324853	3.45e-20	94.0	arCOG15086@1|root,arCOG15086@2157|Archaea,2Y5IR@28890|Euryarchaeota,242F8@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_1828597_56	263820.PTO0903	1.398e-20	103.0	arCOG05369@1|root,arCOG05369@2157|Archaea,2Y5KQ@28890|Euryarchaeota,242GV@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_1828597_51	273075.Ta0591	2.184e-26	126.0	COG0433@1|root,arCOG04034@2157|Archaea,2Y7QK@28890|Euryarchaeota,242BW@183967|Thermoplasmata	183967|Thermoplasmata	L	AAA-like domain	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF87
MMS3_k127_1828597_65	263820.PTO0458	3.387e-10	64.0	arCOG05340@1|root,arCOG05340@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_1828597_24	273116.14325181	6.037e-88	297.0	COG0842@1|root,arCOG01467@2157|Archaea,2XU41@28890|Euryarchaeota,24227@183967|Thermoplasmata	183967|Thermoplasmata	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
MMS3_k127_1828597_14	273075.Ta0869	4.671e-122	399.0	COG1131@1|root,arCOG00194@2157|Archaea,2XUK9@28890|Euryarchaeota,241QH@183967|Thermoplasmata	183967|Thermoplasmata	V	Domain of unknown function (DUF4162)	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
MMS3_k127_1828597_27	263820.PTO0129	7.112e-80	269.0	COG1056@1|root,arCOG00972@2157|Archaea,2XUF7@28890|Euryarchaeota,241PW@183967|Thermoplasmata	183967|Thermoplasmata	F	nicotinamide-nucleotide adenylyltransferase activity	-	-	2.7.7.1	ko:K00952	ko00760,ko01100,map00760,map01100	-	R00137,R03005	RC00002	ko00000,ko00001,ko01000	-	-	-	CTP_transf_like
MMS3_k127_1828597_10	273116.14325342	6.853e-144	467.0	COG0624@1|root,arCOG01107@2157|Archaea,2XU86@28890|Euryarchaeota,241MR@183967|Thermoplasmata	183967|Thermoplasmata	E	Peptidase family M20/M25/M40	-	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
MMS3_k127_1828597_9	515635.Dtur_0830	2.599e-144	472.0	COG0441@1|root,COG0441@2|Bacteria	2|Bacteria	J	threonyl-tRNA aminoacylation	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,ProRS-C_1,tRNA-synt_2b
MMS3_k127_1828597_44	263820.PTO1365	6.553e-47	177.0	COG0560@1|root,arCOG01158@2157|Archaea,2Y79H@28890|Euryarchaeota,241UM@183967|Thermoplasmata	183967|Thermoplasmata	E	haloacid dehalogenase-like hydrolase	-	-	3.1.3.3	ko:K01079	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R00582	RC00017	ko00000,ko00001,ko00002,ko01000,ko01009	-	-	-	HAD
MMS3_k127_1828597_29	263820.PTO0229	1.55e-75	260.0	COG0468@1|root,arCOG00417@2157|Archaea,2XTI2@28890|Euryarchaeota,241QP@183967|Thermoplasmata	183967|Thermoplasmata	L	Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange (By similarity)	radB	-	-	ko:K04484	-	-	-	-	ko00000,ko03400	-	-	-	Rad51
MMS3_k127_1828597_18	263820.PTO0228	6.75e-113	373.0	COG0258@1|root,arCOG04050@2157|Archaea,2XTJD@28890|Euryarchaeota,241MU@183967|Thermoplasmata	183967|Thermoplasmata	L	Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into	fen	-	-	ko:K04799	ko03030,ko03410,ko03450,map03030,map03410,map03450	-	-	-	ko00000,ko00001,ko01000,ko03032,ko03400,ko04147	-	-	-	XPG_I,XPG_N
MMS3_k127_1828597_19	263820.PTO0226	1.532e-111	370.0	COG0162@1|root,arCOG01886@2157|Archaea,2XTA0@28890|Euryarchaeota,241NP@183967|Thermoplasmata	183967|Thermoplasmata	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	tRNA-synt_1b
MMS3_k127_1828597_66	697303.Thewi_2014	7.655e-09	64.0	COG1468@1|root,COG1468@2|Bacteria,1V1U1@1239|Firmicutes,24H50@186801|Clostridia,42G0A@68295|Thermoanaerobacterales	186801|Clostridia	L	TIGRFAM CRISPR-associated protein Cas4	-	-	3.1.12.1	ko:K07464	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	Cas_Cas4
MMS3_k127_1828597_59	273116.14325038	7.508e-20	99.0	COG1354@1|root,arCOG02610@2157|Archaea,2Y6XG@28890|Euryarchaeota,241WP@183967|Thermoplasmata	183967|Thermoplasmata	L	chromosome segregation and condensation protein ScpA	-	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	-
MMS3_k127_1828597_4	263820.PTO0856	1.827e-196	655.0	COG1196@1|root,arCOG00371@2157|Archaea,2XSVK@28890|Euryarchaeota,241K1@183967|Thermoplasmata	183967|Thermoplasmata	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
MMS3_k127_1828597_39	547144.HydHO_0231	7.595e-54	203.0	COG0031@1|root,COG0031@2|Bacteria,2G3Z0@200783|Aquificae	200783|Aquificae	E	Belongs to the cysteine synthase cystathionine beta- synthase family	cysM	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004124,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0019344,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0080146,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.5.1.47	ko:K01738,ko:K12339	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03132,R03601,R04859	RC00020,RC02814,RC02821,RC02876	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
MMS3_k127_1828597_35	273075.Ta0061	3.62e-58	210.0	COG1024@1|root,arCOG00239@2157|Archaea,2XTF0@28890|Euryarchaeota,2428Q@183967|Thermoplasmata	183967|Thermoplasmata	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
MMS3_k127_1828597_7	273075.Ta0582	1.18e-158	509.0	COG0183@1|root,arCOG01282@2157|Archaea,2XT8C@28890|Euryarchaeota,241KE@183967|Thermoplasmata	183967|Thermoplasmata	I	Thiolase, N-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
MMS3_k127_1828597_62	263820.PTO0820	3.576e-15	77.0	COG1383@1|root,arCOG01885@2157|Archaea,2Y7C3@28890|Euryarchaeota,242FZ@183967|Thermoplasmata	183967|Thermoplasmata	J	structural constituent of ribosome	rps17e	-	-	ko:K02962	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17e
MMS3_k127_1828597_46	263820.PTO0821	3.766e-36	142.0	COG0589@1|root,arCOG02053@2157|Archaea,2Y1KW@28890|Euryarchaeota,242E4@183967|Thermoplasmata	183967|Thermoplasmata	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
MMS3_k127_1828597_61	671065.MetMK1DRAFT_00005900	1.368e-16	90.0	arCOG03768@1|root,arCOG03768@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF973
MMS3_k127_1828597_11	273116.14324701	1.529e-137	446.0	COG0484@1|root,arCOG02846@2157|Archaea,2XV5D@28890|Euryarchaeota,241ME@183967|Thermoplasmata	183967|Thermoplasmata	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
MMS3_k127_1828597_1	263820.PTO0840	2.576e-275	861.0	COG0443@1|root,arCOG03060@2157|Archaea,2XT86@28890|Euryarchaeota,241JG@183967|Thermoplasmata	183967|Thermoplasmata	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
MMS3_k127_1828597_49	263820.PTO0839	2.756e-29	124.0	COG0576@1|root,arCOG04772@2157|Archaea,2Y6XU@28890|Euryarchaeota,241XI@183967|Thermoplasmata	183967|Thermoplasmata	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
MMS3_k127_1828597_32	263820.PTO0412	1.883e-66	239.0	COG1041@1|root,arCOG00047@2157|Archaea,2XTD6@28890|Euryarchaeota,241RT@183967|Thermoplasmata	183967|Thermoplasmata	L	Putative RNA methylase family UPF0020	-	-	2.1.1.213	ko:K07446	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	UPF0020
MMS3_k127_1828597_47	273075.Ta1416	4.367e-35	138.0	COG1761@1|root,arCOG04111@2157|Archaea,2XZVZ@28890|Euryarchaeota,241XD@183967|Thermoplasmata	183967|Thermoplasmata	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoL	-	2.7.7.6	ko:K03056	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_L_2
MMS3_k127_1828597_23	273116.14325698	1.641e-100	340.0	COG0446@1|root,arCOG01064@2157|Archaea,2XUFE@28890|Euryarchaeota,24203@183967|Thermoplasmata	183967|Thermoplasmata	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
MMS3_k127_1828597_60	273116.14325697	6.006e-18	89.0	COG2427@1|root,arCOG02113@2157|Archaea,2Y5ZD@28890|Euryarchaeota,242HP@183967|Thermoplasmata	183967|Thermoplasmata	S	Protein of unknown function (DUF1641)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1641
MMS3_k127_1828597_21	273075.Ta0495	5.757e-106	353.0	COG0498@1|root,arCOG01434@2157|Archaea,2XVBI@28890|Euryarchaeota,2423Z@183967|Thermoplasmata	183967|Thermoplasmata	E	Pyridoxal-phosphate dependent enzyme	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
MMS3_k127_1828597_28	263820.PTO0989	5.957e-78	267.0	COG1573@1|root,arCOG00905@2157|Archaea,2Y786@28890|Euryarchaeota,241YB@183967|Thermoplasmata	183967|Thermoplasmata	L	UreE urease accessory protein, C-terminal domain	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
MMS3_k127_1828597_34	1157490.EL26_03640	1.092e-60	220.0	COG0451@1|root,COG0451@2|Bacteria,1TR3K@1239|Firmicutes,4HD3P@91061|Bacilli	91061|Bacilli	GM	Dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
MMS3_k127_1828597_53	263820.PTO0135	4.4e-24	106.0	COG0515@1|root,arCOG03682@2157|Archaea,2XWZP@28890|Euryarchaeota	28890|Euryarchaeota	T	serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	NosD,Pkinase
MMS3_k127_1828597_3	273116.14324987	1.105e-202	639.0	COG0334@1|root,arCOG01352@2157|Archaea,2XU0F@28890|Euryarchaeota,241PE@183967|Thermoplasmata	183967|Thermoplasmata	E	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase	-	-	1.4.1.3,1.4.1.4	ko:K00261,ko:K00262	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
MMS3_k127_1828597_67	263820.PTO1339	2.164e-05	49.0	COG3277@1|root,arCOG02466@2157|Archaea	2157|Archaea	J	RNA-binding protein involved in rRNA processing	gar1	-	-	ko:K07569	-	-	-	-	ko00000,ko03009	-	-	-	Gar1
MMS3_k127_1828597_6	263820.PTO1338	4.371e-173	547.0	COG1405@1|root,arCOG01981@2157|Archaea,2XT0Z@28890|Euryarchaeota,241JU@183967|Thermoplasmata	183967|Thermoplasmata	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	tfbA	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
MMS3_k127_2089394_2	160799.PBOR_11920	4.679e-18	100.0	COG2931@1|root,COG3391@1|root,COG2931@2|Bacteria,COG3391@2|Bacteria,1V255@1239|Firmicutes,4HFUF@91061|Bacilli,26VZT@186822|Paenibacillaceae	91061|Bacilli	M	40-residue YVTN family beta-propeller repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	Collagen,Cytochrom_D1,Lactonase,PD40,Phosphoesterase
MMS3_k127_2089394_3	1056495.Calag_1003	8.612e-18	98.0	COG3391@1|root,arCOG06052@1|root,arCOG02560@2157|Archaea,arCOG06052@2157|Archaea,2XRYP@28889|Crenarchaeota	28889|Crenarchaeota	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_2089394_0	263820.PTO1292	2.637e-71	256.0	COG0303@1|root,arCOG00217@2157|Archaea,2XT2V@28890|Euryarchaeota,2427B@183967|Thermoplasmata	183967|Thermoplasmata	H	MoeA C-terminal region (domain IV)	-	-	2.10.1.1	ko:K03750,ko:K07219	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N,PBP_like
MMS3_k127_2089394_1	273116.14325532	1.334e-33	136.0	COG0746@1|root,arCOG01872@2157|Archaea,2Y4WY@28890|Euryarchaeota,242C0@183967|Thermoplasmata	183967|Thermoplasmata	H	MobA-like NTP transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_3
MMS3_k127_2089394_4	1121377.KB906411_gene501	1.043e-09	59.0	COG1526@1|root,COG1526@2|Bacteria,1WJAY@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH	fdhD	-	-	ko:K02379	-	-	-	-	ko00000	-	-	-	FdhD-NarQ
MMS3_k127_2094595_2	485913.Krac_8237	7.473e-08	62.0	COG0477@1|root,COG2814@2|Bacteria,2G6DM@200795|Chloroflexi	200795|Chloroflexi	EGP	PFAM major facilitator superfamily MFS_1	-	-	-	ko:K08151	-	M00668	-	-	ko00000,ko00002,ko01504,ko02000	2.A.1.2.38,2.A.1.2.39,2.A.1.2.4,2.A.1.2.41,2.A.1.2.68,2.A.1.2.75	-	-	MFS_1,MFS_1_like,Sugar_tr
MMS3_k127_2094595_1	479432.Sros_5104	4.728e-09	70.0	COG3391@1|root,COG3391@2|Bacteria,2GK45@201174|Actinobacteria,4EPVC@85012|Streptosporangiales	201174|Actinobacteria	M	Lactonase, 7-bladed beta-propeller	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_5,Cytochrom_D1,Lactonase
MMS3_k127_2094595_0	656519.Halsa_1260	7.226e-81	287.0	COG0038@1|root,COG5002@1|root,COG0038@2|Bacteria,COG5002@2|Bacteria,1TPX0@1239|Firmicutes,247R4@186801|Clostridia	186801|Clostridia	P	Chloride transporter, ClC family	-	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	-	CBS,Voltage_CLC
MMS3_k127_2172226_18	273075.Ta0084	6.134e-21	104.0	COG0467@1|root,arCOG01693@2157|Archaea	2157|Archaea	T	V4R	-	-	-	ko:K07013	-	-	-	-	ko00000	-	-	-	ATPase,V4R
MMS3_k127_2172226_4	273075.Ta0085m	2.08e-183	582.0	COG4948@1|root,arCOG01168@2157|Archaea,2XTSG@28890|Euryarchaeota,24211@183967|Thermoplasmata	183967|Thermoplasmata	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	GO:0003674,GO:0003824,GO:0008869,GO:0016829,GO:0016835,GO:0016836,GO:0047929	4.2.1.140	ko:K05308	ko00030,ko00052,ko01100,ko01120,ko01200,map00030,map00052,map01100,map01120,map01200	M00308,M00309,M00633	R01538,R03033	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
MMS3_k127_2172226_0	273116.14324403	0.0	1062.0	COG1048@1|root,arCOG01697@2157|Archaea,2XTIZ@28890|Euryarchaeota,241JD@183967|Thermoplasmata	183967|Thermoplasmata	C	Aconitase family (aconitate hydratase)	-	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
MMS3_k127_2172226_14	273116.14324604	1.31e-60	222.0	COG0460@1|root,arCOG01351@2157|Archaea,2XSWF@28890|Euryarchaeota,241RN@183967|Thermoplasmata	183967|Thermoplasmata	E	Homoserine dehydrogenase	-	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	Homoserine_dh,NAD_binding_3
MMS3_k127_2172226_1	273116.14325758	3.06e-218	683.0	COG0174@1|root,arCOG01909@2157|Archaea,2XSYS@28890|Euryarchaeota,241WU@183967|Thermoplasmata	183967|Thermoplasmata	E	Glutamine synthetase, catalytic domain	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
MMS3_k127_2172226_20	273075.Ta1160	4e-17	84.0	COG1758@1|root,arCOG01268@2157|Archaea,2XZSW@28890|Euryarchaeota,241WT@183967|Thermoplasmata	183967|Thermoplasmata	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoK	-	2.7.7.6	ko:K03055	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb6
MMS3_k127_2172226_2	673860.AciM339_0956	6.598e-209	670.0	COG0143@1|root,arCOG00810@2157|Archaea,2XTG5@28890|Euryarchaeota,3F2F7@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF692.Mbar_A0543	Anticodon_1,tRNA-synt_1g,tRNA_bind
MMS3_k127_2172226_17	263820.PTO1272	1.509e-24	107.0	arCOG05400@1|root,arCOG05400@2157|Archaea,2Y4Y7@28890|Euryarchaeota,242CG@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_2172226_16	263820.PTO0419	1.964e-29	122.0	COG1765@1|root,arCOG03685@2157|Archaea,2Y05H@28890|Euryarchaeota,242AT@183967|Thermoplasmata	183967|Thermoplasmata	O	OsmC-like protein	-	-	-	ko:K07397	-	-	-	-	ko00000	-	-	-	OsmC
MMS3_k127_2172226_3	263820.PTO0466	8.541e-186	593.0	COG1384@1|root,arCOG00485@2157|Archaea,2XTR5@28890|Euryarchaeota,241IT@183967|Thermoplasmata	183967|Thermoplasmata	J	lysyl-tRNA aminoacylation	lysS	-	6.1.1.6	ko:K04566	ko00970,map00970	M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1f
MMS3_k127_2172226_9	273116.14325480	1.055e-90	301.0	COG0856@1|root,arCOG00028@2157|Archaea,2XU2R@28890|Euryarchaeota,2421I@183967|Thermoplasmata	183967|Thermoplasmata	F	nucleoside metabolic process	-	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
MMS3_k127_2172226_15	273116.14325479	2.447e-42	160.0	COG0537@1|root,arCOG00419@2157|Archaea,2XWGT@28890|Euryarchaeota,242AC@183967|Thermoplasmata	183967|Thermoplasmata	F	HIT domain	-	-	3.6.1.17	ko:K01518,ko:K02503	ko00230,ko00240,map00230,map00240	-	R00184,R00969,R01232,R02805	RC00002	ko00000,ko00001,ko01000,ko04147	-	-	-	HIT
MMS3_k127_2172226_6	273075.Ta1479m	7.491e-124	402.0	COG0489@1|root,arCOG00585@2157|Archaea,2XTU2@28890|Euryarchaeota,241MZ@183967|Thermoplasmata	183967|Thermoplasmata	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	-	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	ParA
MMS3_k127_2172226_19	523845.AQXV01000050_gene969	3.599e-19	89.0	arCOG05874@1|root,arCOG05874@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_2172226_24	4558.Sb05g016477.1	0.0006291	42.0	2CZVF@1|root,2SBUI@2759|Eukaryota	2759|Eukaryota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_2172226_13	273075.Ta0399	1.693e-62	219.0	COG0221@1|root,arCOG01711@2157|Archaea,2XTSU@28890|Euryarchaeota,241QU@183967|Thermoplasmata	183967|Thermoplasmata	C	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions	ppa	-	3.6.1.1	ko:K01507	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyrophosphatase
MMS3_k127_2172226_10	263820.PTO0906	8.846e-80	274.0	COG0462@1|root,arCOG00067@2157|Archaea,2XTA8@28890|Euryarchaeota,241PU@183967|Thermoplasmata	183967|Thermoplasmata	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	-	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran,Pribosyltran_N
MMS3_k127_2172226_11	273075.Ta0118m	1.968e-73	254.0	COG1859@1|root,arCOG04063@2157|Archaea,2XWPC@28890|Euryarchaeota,2427Y@183967|Thermoplasmata	183967|Thermoplasmata	J	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase	kptA	-	-	ko:K07559	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PTS_2-RNA
MMS3_k127_2172226_5	263820.PTO0611	6.445e-182	578.0	COG0112@1|root,arCOG00070@2157|Archaea,2XU0H@28890|Euryarchaeota,241JA@183967|Thermoplasmata	183967|Thermoplasmata	E	Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
MMS3_k127_2172226_22	1201288.M900_0395	7.214e-16	83.0	COG1051@1|root,COG1051@2|Bacteria	2|Bacteria	F	GDP-mannose mannosyl hydrolase activity	-	-	3.6.1.13,3.6.1.55,3.6.1.67	ko:K01515,ko:K03574,ko:K08310,ko:K19965	ko00230,ko00790,map00230,map00790	M00126	R01054,R04638	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	NUDIX
MMS3_k127_2172226_8	273075.Ta1314	1.549e-91	308.0	COG0582@1|root,arCOG01241@2157|Archaea,2XV3E@28890|Euryarchaeota,2422T@183967|Thermoplasmata	183967|Thermoplasmata	L	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules	xerA	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_4,Phage_integrase
MMS3_k127_2172226_7	273116.14324478	1.065e-99	336.0	COG0142@1|root,arCOG01726@2157|Archaea,2XTAC@28890|Euryarchaeota,241XW@183967|Thermoplasmata	183967|Thermoplasmata	H	Polyprenyl synthetase	-	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13787	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
MMS3_k127_2172226_12	273116.14324237	1.863e-70	248.0	COG1814@1|root,arCOG01096@2157|Archaea,2XWEX@28890|Euryarchaeota,2423V@183967|Thermoplasmata	183967|Thermoplasmata	S	Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin,VIT1
MMS3_k127_2181236_0	273075.Ta0365	3.441e-192	606.0	COG0582@1|root,arCOG01241@2157|Archaea,2XWM9@28890|Euryarchaeota	28890|Euryarchaeota	L	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_2181236_12	273075.Ta0186	7.737e-33	142.0	COG0477@1|root,arCOG00135@2157|Archaea,2Y79X@28890|Euryarchaeota,241YA@183967|Thermoplasmata	183967|Thermoplasmata	G	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS3_k127_2181236_13	595460.RRSWK_00448	7.112e-31	133.0	COG0667@1|root,COG0667@2|Bacteria,2IYJW@203682|Planctomycetes	203682|Planctomycetes	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
MMS3_k127_2181236_9	1382230.ASAP_2635	3.264e-46	181.0	COG0535@1|root,COG0535@2|Bacteria,1MUQP@1224|Proteobacteria,2TTS5@28211|Alphaproteobacteria,2JRCB@204441|Rhodospirillales	204441|Rhodospirillales	S	Elongator protein 3, MiaB family, Radical SAM	pqqE	-	-	ko:K06139	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SPASM
MMS3_k127_2181236_11	273075.Ta0615	1.989e-33	148.0	arCOG03691@1|root,arCOG03691@2157|Archaea,2Y1YV@28890|Euryarchaeota,242AJ@183967|Thermoplasmata	183967|Thermoplasmata	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_2181236_6	1168034.FH5T_16805	9.615e-67	232.0	COG0225@1|root,COG0225@2|Bacteria,4NMAJ@976|Bacteroidetes,2FNTE@200643|Bacteroidia	976|Bacteroidetes	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11,1.8.4.12	ko:K07304,ko:K12267	-	-	-	-	ko00000,ko01000	-	-	-	PMSR,SelR
MMS3_k127_2181236_8	575590.HMPREF0156_00092	3.751e-53	189.0	COG0225@1|root,COG0229@1|root,COG0225@2|Bacteria,COG0229@2|Bacteria,4NMAJ@976|Bacteroidetes	976|Bacteroidetes	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11,1.8.4.12	ko:K07304,ko:K12267	-	-	-	-	ko00000,ko01000	-	-	-	PMSR,SelR
MMS3_k127_2181236_7	1415775.U729_681	1.012e-63	230.0	COG3842@1|root,COG3842@2|Bacteria,1TP2M@1239|Firmicutes,247JR@186801|Clostridia,36EAA@31979|Clostridiaceae	186801|Clostridia	P	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	-	-	3.6.3.30	ko:K02010	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10	-	-	ABC_tran,TOBE_2
MMS3_k127_2181236_15	1463845.JOIG01000012_gene257	4.735e-23	115.0	COG1178@1|root,COG1178@2|Bacteria,2GKDH@201174|Actinobacteria	201174|Actinobacteria	P	ABC-type Fe3 transport system permease component	thiP	-	-	ko:K02011,ko:K02063	ko02010,map02010	M00190,M00191	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10,3.A.1.19	-	-	BPD_transp_1
MMS3_k127_2181236_14	1042877.GQS_10685	1.722e-29	132.0	COG4143@1|root,arCOG00226@2157|Archaea,2XT44@28890|Euryarchaeota,24311@183968|Thermococci	183968|Thermococci	H	ABC-type thiamine transport system, periplasmic component	-	-	-	ko:K02064	ko02010,map02010	M00191	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.19	-	-	SBP_bac_6,SBP_bac_8
MMS3_k127_2181236_5	1006006.Mcup_0026	1.937e-68	238.0	COG0035@1|root,arCOG04128@2157|Archaea,2XQ50@28889|Crenarchaeota	28889|Crenarchaeota	F	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate	upp	GO:0003674,GO:0003824,GO:0004849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043097,GO:0043174,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.2.9	ko:K00761	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000	-	-	-	UPRTase
MMS3_k127_2181236_4	273075.Ta0812	8.945e-86	297.0	COG0517@1|root,arCOG00601@2157|Archaea,2XT75@28890|Euryarchaeota,241TW@183967|Thermoplasmata	183967|Thermoplasmata	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
MMS3_k127_2181236_3	263820.PTO0728	2.594e-95	320.0	COG0656@1|root,arCOG01619@2157|Archaea,2XTR0@28890|Euryarchaeota	28890|Euryarchaeota	S	COG0656 Aldo keto reductases, related to diketogulonate reductase	yafB	-	1.1.1.346	ko:K06222	-	-	-	-	ko00000,ko01000	-	-	-	Aldo_ket_red
MMS3_k127_2181236_16	797210.Halxa_2989	1.861e-12	72.0	COG1487@1|root,arCOG02219@2157|Archaea,2XX7I@28890|Euryarchaeota,23VMN@183963|Halobacteria	183963|Halobacteria	V	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	PIN
MMS3_k127_2181236_10	273075.Ta0728	3.432e-36	144.0	arCOG07179@1|root,arCOG07179@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_2181236_2	273116.14324353	1.184e-106	358.0	COG0477@1|root,arCOG00130@2157|Archaea,2Y7A2@28890|Euryarchaeota,241Z4@183967|Thermoplasmata	183967|Thermoplasmata	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS3_k127_2181236_1	263820.PTO0195	7.104e-155	507.0	COG0531@1|root,arCOG00009@2157|Archaea,2Y2K9@28890|Euryarchaeota,24257@183967|Thermoplasmata	183967|Thermoplasmata	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
MMS3_k127_2416140_11	309798.COPRO5265_0041	4.27e-25	117.0	COG4974@1|root,COG4974@2|Bacteria,1V2D0@1239|Firmicutes,25C3U@186801|Clostridia,42GCT@68295|Thermoanaerobacterales	186801|Clostridia	L	Belongs to the 'phage' integrase family	-	-	-	ko:K03733	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_int_SAM_4,Phage_integrase
MMS3_k127_2416140_3	273116.14324677	4.772e-78	273.0	COG1537@1|root,arCOG01741@2157|Archaea,2XTQ4@28890|Euryarchaeota,241SZ@183967|Thermoplasmata	183967|Thermoplasmata	J	May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity	pelA	-	-	ko:K06965	ko03015,map03015	-	-	-	ko00000,ko00001	-	-	-	eRF1_1,eRF1_3
MMS3_k127_2416140_10	439481.Aboo_0341	7.103e-29	121.0	COG1656@1|root,arCOG04290@2157|Archaea,2XXTT@28890|Euryarchaeota,3F3CD@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Mut7-C RNAse domain	-	-	-	ko:K09122	-	-	-	-	ko00000	-	-	-	Mut7-C
MMS3_k127_2416140_6	273116.14324674	1.225e-55	201.0	arCOG05327@1|root,arCOG05327@2157|Archaea,2Y236@28890|Euryarchaeota,2429B@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_2416140_5	263820.PTO1250	7.928e-56	225.0	arCOG05397@1|root,arCOG05397@2157|Archaea,2Y4YZ@28890|Euryarchaeota,242E9@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_2416140_1	273116.14324672	3.753e-136	442.0	COG0057@1|root,arCOG00493@2157|Archaea,2XT16@28890|Euryarchaeota,241JM@183967|Thermoplasmata	183967|Thermoplasmata	G	4-hydroxy-tetrahydrodipicolinate reductase	gap	-	1.2.1.59	ko:K00150	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166	R01061,R01063	RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_N,Gp_dh_C
MMS3_k127_2416140_0	273075.Ta1104	6.318e-169	535.0	COG0468@1|root,arCOG00415@2157|Archaea,2XT80@28890|Euryarchaeota,241KB@183967|Thermoplasmata	183967|Thermoplasmata	L	Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules	radA	-	-	ko:K04483	-	-	-	-	ko00000,ko03400	-	-	-	HHH_5,Rad51
MMS3_k127_2416140_7	263820.PTO0908	1.859e-46	174.0	COG2150@1|root,arCOG02316@2157|Archaea,2XWH9@28890|Euryarchaeota,241VB@183967|Thermoplasmata	183967|Thermoplasmata	S	regulator of amino acid metabolism, contains ACT domain	-	-	-	ko:K07103	-	-	-	-	ko00000	-	-	-	ACT
MMS3_k127_2416140_2	1128421.JAGA01000003_gene3653	2.189e-102	354.0	COG3975@1|root,COG3975@2|Bacteria,2NQU3@2323|unclassified Bacteria	2|Bacteria	S	M61 glycyl aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Peptidase_M61
MMS3_k127_2416140_8	273116.14324393	1.483e-39	153.0	COG1779@1|root,arCOG04265@2157|Archaea,2XWNA@28890|Euryarchaeota,2429R@183967|Thermoplasmata	183967|Thermoplasmata	S	ZPR1 zinc-finger domain	-	-	-	ko:K06874	-	-	-	-	ko00000	-	-	-	zf-ZPR1
MMS3_k127_2416140_4	273116.14324395	6.113e-72	250.0	COG1608@1|root,arCOG00860@2157|Archaea,2XSUI@28890|Euryarchaeota,241QT@183967|Thermoplasmata	183967|Thermoplasmata	F	Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids	-	-	2.7.4.26	ko:K06981	ko00900,ko01110,ko01130,map00900,map01110,map01130	-	R10093	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
MMS3_k127_2416140_9	1095726.HMPREF1116_0487	6.203e-33	134.0	COG1670@1|root,COG1670@2|Bacteria,1V7MA@1239|Firmicutes,4IQBQ@91061|Bacilli	91061|Bacilli	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_3
MMS3_k127_2735458_69	679926.Mpet_2168	1.604e-31	125.0	COG3727@1|root,arCOG06555@2157|Archaea,2Y4XN@28890|Euryarchaeota,2NB57@224756|Methanomicrobia	224756|Methanomicrobia	L	Protein of unknown function (DUF559)	-	-	-	ko:K07458	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DUF559,Vsr
MMS3_k127_2735458_44	1123405.AUMM01000007_gene926	4.014e-75	268.0	COG4934@1|root,COG4934@2|Bacteria,1UYFY@1239|Firmicutes,4HFAH@91061|Bacilli,26PHT@186821|Sporolactobacillaceae	91061|Bacilli	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8,Pro-kuma_activ
MMS3_k127_2735458_23	216594.MMAR_0119	3.859e-126	414.0	COG0778@1|root,COG0778@2|Bacteria,2H3K6@201174|Actinobacteria	201174|Actinobacteria	C	Putative TM nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
MMS3_k127_2735458_57	1381123.AYOD01000060_gene1649	2.797e-55	207.0	COG4447@1|root,COG4447@2|Bacteria,1ND1J@1224|Proteobacteria,2U0UY@28211|Alphaproteobacteria,43IAS@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	protein related to plant photosystem II stability assembly factor	-	-	-	-	-	-	-	-	-	-	-	-	BNR,Sortilin-Vps10
MMS3_k127_2735458_73	273075.Ta0916	5.979e-29	117.0	arCOG05390@1|root,arCOG05390@2157|Archaea,2Y4YT@28890|Euryarchaeota,242E1@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_2735458_68	263820.PTO1201	6.364e-35	137.0	COG1522@1|root,arCOG01580@2157|Archaea,2XX5M@28890|Euryarchaeota,241X8@183967|Thermoplasmata	183967|Thermoplasmata	K	helix_turn_helix ASNC type	-	-	-	ko:K06154	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24
MMS3_k127_2735458_67	273075.Ta0912	9.164e-37	142.0	COG1581@1|root,arCOG01753@2157|Archaea,2XZH4@28890|Euryarchaeota,242BE@183967|Thermoplasmata	183967|Thermoplasmata	J	Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes	albA	-	-	ko:K03622	-	-	-	-	ko00000	-	-	-	Alba
MMS3_k127_2735458_26	263820.PTO1199	6.751e-119	390.0	COG0142@1|root,arCOG01726@2157|Archaea,2XT85@28890|Euryarchaeota,241QG@183967|Thermoplasmata	183967|Thermoplasmata	H	Polyprenyl synthetase	-	-	2.5.1.1,2.5.1.10,2.5.1.29,2.5.1.90	ko:K02523,ko:K13787	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365	R01658,R02003,R02061,R09248	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
MMS3_k127_2735458_5	263820.PTO0225	4.32e-205	650.0	COG1012@1|root,arCOG01252@2157|Archaea,2XUKB@28890|Euryarchaeota,2421F@183967|Thermoplasmata	183967|Thermoplasmata	C	Aldehyde dehydrogenase family	-	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
MMS3_k127_2735458_18	263820.PTO0187	1.713e-145	503.0	COG4934@1|root,arCOG03665@2157|Archaea,2Y1PU@28890|Euryarchaeota,241Z3@183967|Thermoplasmata	183967|Thermoplasmata	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
MMS3_k127_2735458_35	263820.PTO0802	2.901e-97	331.0	COG1467@1|root,arCOG04110@2157|Archaea,2XUZF@28890|Euryarchaeota,241NB@183967|Thermoplasmata	183967|Thermoplasmata	L	Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair	priS	-	-	ko:K02683	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_primase_S
MMS3_k127_2735458_51	1162668.LFE_0447	1.791e-64	224.0	COG1592@1|root,COG1592@2|Bacteria,3J0RY@40117|Nitrospirae	40117|Nitrospirae	C	Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
MMS3_k127_2735458_80	638303.Thal_0939	1.346e-22	105.0	COG0247@1|root,COG0247@2|Bacteria	2|Bacteria	C	lactate metabolic process	-	-	-	-	-	-	-	-	-	-	-	-	DUF3501
MMS3_k127_2735458_90	234267.Acid_1793	5.062e-07	57.0	2DB97@1|root,33TRP@2|Bacteria,3Y7NY@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_2735458_12	273075.Ta0974	2.569e-174	553.0	COG1960@1|root,arCOG01707@2157|Archaea,2XT5S@28890|Euryarchaeota,2425E@183967|Thermoplasmata	183967|Thermoplasmata	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
MMS3_k127_2735458_59	273116.14325381	3.35e-52	194.0	COG1801@1|root,arCOG04291@2157|Archaea,2XY6C@28890|Euryarchaeota	28890|Euryarchaeota	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
MMS3_k127_2735458_37	273116.14325380	3.38e-92	318.0	COG0252@1|root,arCOG01924@2157|Archaea,2XTN1@28890|Euryarchaeota,241SW@183967|Thermoplasmata	183967|Thermoplasmata	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate	gatD	-	6.3.5.7	ko:K09482	ko00970,ko01100,map00970,map01100	-	R03905	RC00010	ko00000,ko00001,ko01000	-	-	-	Asparaginase
MMS3_k127_2735458_14	273116.14325379	1.505e-158	519.0	COG2511@1|root,arCOG01719@2157|Archaea,2XT73@28890|Euryarchaeota,241KN@183967|Thermoplasmata	183967|Thermoplasmata	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate	gatE	-	6.3.5.7	ko:K03330	ko00970,ko01100,map00970,map01100	-	R03905	RC00010	ko00000,ko00001,ko01000	-	-	-	GatB_N
MMS3_k127_2735458_63	263820.PTO1400	9.739e-46	169.0	COG0838@1|root,arCOG01557@2157|Archaea,2Y7BF@28890|Euryarchaeota,242B8@183967|Thermoplasmata	183967|Thermoplasmata	C	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3	-	-	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
MMS3_k127_2735458_41	273075.Ta0969m	1.789e-82	276.0	COG0377@1|root,arCOG01554@2157|Archaea,2XTP1@28890|Euryarchaeota,241SV@183967|Thermoplasmata	183967|Thermoplasmata	C	NADH ubiquinone oxidoreductase, 20 Kd subunit	-	-	1.5.98.3,1.6.5.3	ko:K00331,ko:K22159	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1,3.D.9.1	-	-	Oxidored_q6
MMS3_k127_2735458_70	1033743.CAES01000105_gene3584	6.377e-31	127.0	COG0852@1|root,COG0852@2|Bacteria,1UFNI@1239|Firmicutes,4HDV1@91061|Bacilli,26RPJ@186822|Paenibacillaceae	91061|Bacilli	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
MMS3_k127_2735458_9	273116.14325375	8.587e-183	577.0	COG0649@1|root,arCOG01548@2157|Archaea,2XTWF@28890|Euryarchaeota,241MP@183967|Thermoplasmata	183967|Thermoplasmata	C	Respiratory-chain NADH dehydrogenase, 49 Kd subunit	-	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
MMS3_k127_2735458_21	273116.14325374	2.966e-133	433.0	COG1005@1|root,arCOG01546@2157|Archaea,2XT7N@28890|Euryarchaeota,241R1@183967|Thermoplasmata	183967|Thermoplasmata	C	NADH dehydrogenase	-	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
MMS3_k127_2735458_55	273116.14325373	4.742e-60	212.0	COG1143@1|root,arCOG01543@2157|Archaea,2Y79M@28890|Euryarchaeota,241VP@183967|Thermoplasmata	183967|Thermoplasmata	C	4Fe-4S dicluster domain	-	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4_7
MMS3_k127_2735458_84	273075.Ta0964	1.18e-18	87.0	COG0839@1|root,arCOG04654@2157|Archaea,2Y7C8@28890|Euryarchaeota,242GG@183967|Thermoplasmata	183967|Thermoplasmata	C	NADH-ubiquinone/plastoquinone oxidoreductase chain 6	-	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
MMS3_k127_2735458_77	273075.Ta0962	4.479e-25	107.0	COG0713@1|root,arCOG03073@2157|Archaea,2Y70N@28890|Euryarchaeota,242BP@183967|Thermoplasmata	183967|Thermoplasmata	C	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L	-	-	1.6.5.3	ko:K00340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
MMS3_k127_2735458_4	273075.Ta0961	6.641e-228	721.0	COG1009@1|root,arCOG01539@2157|Archaea,2XT4R@28890|Euryarchaeota,241J9@183967|Thermoplasmata	183967|Thermoplasmata	C	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus	-	-	1.5.98.3,1.6.5.3	ko:K00341,ko:K22167	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1,3.D.9.1	-	-	Proton_antipo_M,Proton_antipo_N
MMS3_k127_2735458_19	273116.14325367	1.553e-136	450.0	COG1008@1|root,arCOG01538@2157|Archaea,2XTP0@28890|Euryarchaeota,241NU@183967|Thermoplasmata	183967|Thermoplasmata	C	Proton-conducting membrane transporter	-	-	1.5.98.3,1.6.5.3	ko:K00342,ko:K22168	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1,3.D.9.1	-	-	Proton_antipo_M
MMS3_k127_2735458_20	273075.Ta0959	1.021e-134	445.0	COG1007@1|root,arCOG01540@2157|Archaea,2XSY7@28890|Euryarchaeota,241P2@183967|Thermoplasmata	183967|Thermoplasmata	C	Proton-conducting membrane transporter	-	-	1.5.98.3,1.6.5.3	ko:K00343,ko:K22169	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1,3.D.9.1	-	-	Proton_antipo_M
MMS3_k127_2735458_86	273075.Ta0958	1.467e-11	69.0	arCOG05378@1|root,arCOG05378@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_2735458_81	263820.PTO1410	1.496e-22	98.0	arCOG05405@1|root,arCOG05405@2157|Archaea,2Y539@28890|Euryarchaeota,242FK@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_2735458_85	616991.JPOO01000001_gene3189	1.52e-15	86.0	COG1024@1|root,COG1024@2|Bacteria,4NFEM@976|Bacteroidetes,1HWQA@117743|Flavobacteriia,23GN9@178469|Arenibacter	976|Bacteroidetes	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	-	ECH_1
MMS3_k127_2735458_49	273116.14324589	2.836e-70	246.0	COG0805@1|root,arCOG01919@2157|Archaea,2Y7D8@28890|Euryarchaeota,2423Y@183967|Thermoplasmata	183967|Thermoplasmata	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
MMS3_k127_2735458_76	273075.Ta1223a	4.278e-25	107.0	COG1826@1|root,arCOG02694@2157|Archaea,2Y23W@28890|Euryarchaeota,242BR@183967|Thermoplasmata	183967|Thermoplasmata	U	mttA/Hcf106 family	-	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
MMS3_k127_2735458_75	273075.Ta0956	4.281e-26	113.0	arCOG05406@1|root,arCOG05406@2157|Archaea,2Y4Q6@28890|Euryarchaeota,242E0@183967|Thermoplasmata	183967|Thermoplasmata	S	Thermoplasma acidophilum protein TA0956	-	-	-	-	-	-	-	-	-	-	-	-	TA0956
MMS3_k127_2735458_33	273116.14325361	7.577e-104	340.0	COG0450@1|root,arCOG00312@2157|Archaea,2XTKD@28890|Euryarchaeota,2420M@183967|Thermoplasmata	183967|Thermoplasmata	O	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides	-	-	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	1-cysPrx_C,AhpC-TSA
MMS3_k127_2735458_24	273075.Ta0955	5.418e-125	408.0	COG0113@1|root,arCOG04300@2157|Archaea,2XSZ8@28890|Euryarchaeota,241IJ@183967|Thermoplasmata	183967|Thermoplasmata	H	Delta-aminolevulinic acid dehydratase	-	-	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
MMS3_k127_2735458_31	273116.14325360	5.055e-107	363.0	COG0467@1|root,arCOG01178@2157|Archaea,2Y0GM@28890|Euryarchaeota	28890|Euryarchaeota	T	PFAM GvpD gas vesicle	-	-	-	-	-	-	-	-	-	-	-	-	GvpD
MMS3_k127_2735458_17	1131266.ARWQ01000001_gene1124	7.861e-149	480.0	COG0180@1|root,arCOG01887@2157|Archaea,41SDK@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the class-I aminoacyl-tRNA synthetase family	-	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
MMS3_k127_2735458_13	273075.Ta1212	8.935e-167	529.0	COG0182@1|root,arCOG01123@2157|Archaea,2Y86P@28890|Euryarchaeota,241IN@183967|Thermoplasmata	183967|Thermoplasmata	J	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	-	-	5.3.1.23	ko:K03239,ko:K08963	ko00270,ko01100,ko03013,map00270,map01100,map03013	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000,ko03012	-	-	-	IF-2B
MMS3_k127_2735458_78	273116.14325447	7.279e-25	106.0	COG2012@1|root,arCOG04258@2157|Archaea,2Y6HJ@28890|Euryarchaeota,241W1@183967|Thermoplasmata	183967|Thermoplasmata	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoH	-	2.7.7.6	ko:K03053	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb5_C
MMS3_k127_2735458_0	273075.Ta0390	0.0	1924.0	COG0085@1|root,arCOG01762@2157|Archaea,2XU1X@28890|Euryarchaeota,241IZ@183967|Thermoplasmata	183967|Thermoplasmata	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	-	-	2.7.7.6	ko:K13798	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_4,RNA_pol_Rpb2_5,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
MMS3_k127_2735458_1	273075.Ta0391	0.0	1429.0	COG0086@1|root,arCOG04257@2157|Archaea,2XTBZ@28890|Euryarchaeota,241IQ@183967|Thermoplasmata	183967|Thermoplasmata	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	-	-	2.7.7.6	ko:K03041	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
MMS3_k127_2735458_10	273116.14325444	1.446e-180	578.0	COG0086@1|root,arCOG04256@2157|Archaea,2XTJ6@28890|Euryarchaeota,241KY@183967|Thermoplasmata	183967|Thermoplasmata	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA2	-	2.7.7.6	ko:K03042	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb1_5
MMS3_k127_2735458_58	273116.14325443	1.148e-54	195.0	COG0195@1|root,arCOG01760@2157|Archaea,2Y6CG@28890|Euryarchaeota,241TM@183967|Thermoplasmata	183967|Thermoplasmata	K	Participates in transcription termination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	-
MMS3_k127_2735458_62	273075.Ta0394a	8.322e-48	173.0	COG0361@1|root,arCOG01179@2157|Archaea,2XXX0@28890|Euryarchaeota,241TY@183967|Thermoplasmata	183967|Thermoplasmata	J	Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits	eif1a	-	-	ko:K03236	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	eIF-1a
MMS3_k127_2735458_47	263820.PTO0252	4.283e-72	251.0	COG1718@1|root,arCOG01180@2157|Archaea,2XU2H@28890|Euryarchaeota,241T5@183967|Thermoplasmata	183967|Thermoplasmata	T	RIO-like kinase	-	-	2.7.11.1	ko:K07178	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko01001,ko03009	-	-	-	RIO1
MMS3_k127_2735458_52	273075.Ta0397	1.182e-62	220.0	COG1094@1|root,arCOG04150@2157|Archaea,2XUHX@28890|Euryarchaeota,241QS@183967|Thermoplasmata	183967|Thermoplasmata	J	K homology RNA-binding domain	-	-	-	ko:K06961	-	-	-	-	ko00000,ko03009	-	-	-	KH_1
MMS3_k127_2735458_89	1041930.Mtc_0319	1.745e-08	64.0	COG1587@1|root,arCOG02048@2157|Archaea,2XTA1@28890|Euryarchaeota	28890|Euryarchaeota	H	Uroporphyrinogen-III synthase	hemD	-	4.2.1.75	ko:K01719	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165	RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4
MMS3_k127_2735458_46	273075.Ta0572	5.438e-73	256.0	COG0181@1|root,arCOG04299@2157|Archaea,2XTBP@28890|Euryarchaeota,241PT@183967|Thermoplasmata	183967|Thermoplasmata	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	-	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	-	Porphobil_deam,Porphobil_deamC
MMS3_k127_2735458_27	634498.mru_0999	2.88e-118	393.0	COG0001@1|root,arCOG00918@2157|Archaea,2XTRI@28890|Euryarchaeota,23NIZ@183925|Methanobacteria	183925|Methanobacteria	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
MMS3_k127_2735458_54	273075.Ta0926	4.557e-60	220.0	COG2520@1|root,arCOG10124@2157|Archaea,2XTPV@28890|Euryarchaeota,241TB@183967|Thermoplasmata	183967|Thermoplasmata	J	Met-10+ like-protein	-	-	2.5.1.114	ko:K07055	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Met_10
MMS3_k127_2735458_29	273116.14324820	1.858e-112	382.0	COG0072@1|root,arCOG00412@2157|Archaea,2XTD5@28890|Euryarchaeota,241N1@183967|Thermoplasmata	183967|Thermoplasmata	J	phenylalanine-tRNA ligase activity	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5
MMS3_k127_2735458_91	273075.Ta0550m	8.955e-05	49.0	COG3609@1|root,arCOG06966@2157|Archaea	2157|Archaea	K	PFAM CopG domain protein DNA-binding domain protein	-	-	-	ko:K07722	-	-	-	-	ko00000,ko03000	-	-	-	RHH_1
MMS3_k127_2735458_61	273116.14324821	4.024e-48	179.0	COG0663@1|root,arCOG01849@2157|Archaea,2XXXX@28890|Euryarchaeota,2428B@183967|Thermoplasmata	183967|Thermoplasmata	S	Bacterial transferase hexapeptide (six repeats)	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
MMS3_k127_2735458_39	273075.Ta0561	1.178e-86	324.0	COG0457@1|root,arCOG05326@2157|Archaea,2Y4PM@28890|Euryarchaeota,242DR@183967|Thermoplasmata	183967|Thermoplasmata	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
MMS3_k127_2735458_65	273075.Ta0562	5.289e-42	161.0	COG1994@1|root,arCOG00614@2157|Archaea,2XX7B@28890|Euryarchaeota,241UR@183967|Thermoplasmata	183967|Thermoplasmata	S	Peptidase family M50	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_2735458_82	263820.PTO1163	1.377e-21	96.0	COG2888@1|root,arCOG01989@2157|Archaea,2Y77Z@28890|Euryarchaeota,242HV@183967|Thermoplasmata	183967|Thermoplasmata	J	Domain of unknown function (DUF1610)	-	-	-	ko:K07580	-	-	-	-	ko00000	-	-	-	DUF1610
MMS3_k127_2735458_79	273116.14324834	1.094e-23	102.0	COG2092@1|root,arCOG01988@2157|Archaea,2Y7BM@28890|Euryarchaeota,242D1@183967|Thermoplasmata	183967|Thermoplasmata	J	Promotes the exchange of GDP for GTP in EF-1-alpha GDP, thus allowing the regeneration of EF-1-alpha GTP that could then be used to form the ternary complex EF-1-alpha GTP AAtRNA	ef1b	-	-	ko:K03232	-	-	-	-	ko00000,ko03012	-	-	-	EF1_GNE
MMS3_k127_2735458_38	263820.PTO1165	2.277e-88	303.0	COG1215@1|root,arCOG01389@2157|Archaea,2Y7AD@28890|Euryarchaeota,24212@183967|Thermoplasmata	183967|Thermoplasmata	M	Glycosyl transferase family 21	-	-	-	ko:K00786	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_transf_21
MMS3_k127_2735458_15	263820.PTO1166	2.296e-157	508.0	COG1109@1|root,arCOG00767@2157|Archaea,2XT1X@28890|Euryarchaeota,241IG@183967|Thermoplasmata	183967|Thermoplasmata	G	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III	-	-	5.4.2.2,5.4.2.8	ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
MMS3_k127_2735458_53	263820.PTO1167	1.291e-61	218.0	COG0558@1|root,arCOG00670@2157|Archaea,2XWJ0@28890|Euryarchaeota,241RQ@183967|Thermoplasmata	183967|Thermoplasmata	I	CDP-alcohol phosphatidyltransferase	-	-	2.7.8.39	ko:K17884	-	-	R10464	RC00002,RC00078	ko00000,ko01000	-	-	-	CDP-OH_P_transf
MMS3_k127_2735458_72	273075.Ta0570	1.327e-30	126.0	COG1936@1|root,arCOG01038@2157|Archaea,2Y662@28890|Euryarchaeota,242EY@183967|Thermoplasmata	183967|Thermoplasmata	F	Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates	-	-	2.7.4.3	ko:K18532	ko00230,ko01100,ko01110,ko01130,ko03008,map00230,map01100,map01110,map01130,map03008	M00049	R00127,R01547	RC00002	ko00000,ko00001,ko00002,ko01000,ko03009	-	-	-	AAA_18
MMS3_k127_2735458_32	273116.14324814	1.953e-105	357.0	COG1571@1|root,arCOG01115@2157|Archaea,2XTGD@28890|Euryarchaeota,241M9@183967|Thermoplasmata	183967|Thermoplasmata	J	ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA	tiaS	-	6.3.4.22	ko:K06932	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1743
MMS3_k127_2735458_30	263820.PTO1378	1.333e-110	362.0	COG0020@1|root,arCOG01532@2157|Archaea,2XSW1@28890|Euryarchaeota,241N5@183967|Thermoplasmata	183967|Thermoplasmata	H	Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids	uppS	-	2.5.1.89	ko:K15888	ko00900,map00900	-	R09730	RC00279,RC02839	ko00000,ko00001,ko01000	-	-	-	Prenyltransf
MMS3_k127_2735458_48	263820.PTO1379	1.34e-71	253.0	COG2520@1|root,arCOG00033@2157|Archaea,2XTSI@28890|Euryarchaeota,241R8@183967|Thermoplasmata	183967|Thermoplasmata	J	Met-10+ like-protein	-	-	2.1.1.228	ko:K15429	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	Met_10
MMS3_k127_2735458_7	273116.14325044	3.432e-194	627.0	COG1204@1|root,arCOG00553@2157|Archaea,2XSV4@28890|Euryarchaeota,241JB@183967|Thermoplasmata	183967|Thermoplasmata	L	DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks	hel308	-	-	ko:K03726	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HHH_5,Helicase_C
MMS3_k127_2735458_8	273116.14325254	2.119e-184	584.0	COG0499@1|root,arCOG04137@2157|Archaea,2XT4S@28890|Euryarchaeota,241J8@183967|Thermoplasmata	183967|Thermoplasmata	F	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
MMS3_k127_2735458_87	1123303.AQVD01000001_gene864	1.203e-09	66.0	COG0454@1|root,COG0456@2|Bacteria,1V4RP@1239|Firmicutes,4HHSD@91061|Bacilli	91061|Bacilli	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
MMS3_k127_2735458_22	273116.14324955	1.707e-131	425.0	COG1940@1|root,arCOG04280@2157|Archaea,2XUQY@28890|Euryarchaeota,24259@183967|Thermoplasmata	183967|Thermoplasmata	G	ROK family	-	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
MMS3_k127_2735458_34	273075.Ta1083	1.99e-102	348.0	COG1030@1|root,arCOG01910@2157|Archaea,2XW1R@28890|Euryarchaeota,2421P@183967|Thermoplasmata	183967|Thermoplasmata	O	NfeD-like C-terminal, partner-binding	-	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	CLP_protease,NfeD
MMS3_k127_2735458_11	273075.Ta0946	4.761e-177	563.0	COG0017@1|root,arCOG00406@2157|Archaea,2XTRE@28890|Euryarchaeota,241JY@183967|Thermoplasmata	183967|Thermoplasmata	J	Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp)	aspS	-	6.1.1.23	ko:K09759	ko00970,map00970	M00360	R03647,R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
MMS3_k127_2735458_64	479433.Caci_5199	4.963e-42	167.0	COG0809@1|root,COG0809@2|Bacteria,2GN51@201174|Actinobacteria	201174|Actinobacteria	J	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	queA	-	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
MMS3_k127_2735458_74	1211777.BN77_p11184	9.101e-28	121.0	COG0300@1|root,COG0300@2|Bacteria,1R27W@1224|Proteobacteria,2TZD9@28211|Alphaproteobacteria,4BCEC@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
MMS3_k127_2735458_36	273075.Ta0947	5.69e-96	324.0	COG1250@1|root,arCOG00250@2157|Archaea,2XTMV@28890|Euryarchaeota	28890|Euryarchaeota	I	3-hydroxyacyl-CoA dehydrogenase	hbd	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
MMS3_k127_2735458_83	273075.Ta0947a	6.276e-20	92.0	arCOG05393@1|root,arCOG05393@2157|Archaea,2Y5IJ@28890|Euryarchaeota,242HG@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_2735458_71	439481.Aboo_1419	7.066e-31	126.0	COG1813@1|root,arCOG01863@2157|Archaea,2XXND@28890|Euryarchaeota,3F2TJ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	Helix-turn-helix XRE-family like proteins	-	-	-	ko:K03627	-	-	-	-	ko00000	-	-	-	HTH_3
MMS3_k127_2735458_56	273116.14325356	3.099e-58	209.0	COG0513@1|root,arCOG00078@2157|Archaea,2XTFM@28890|Euryarchaeota,241RY@183967|Thermoplasmata	183967|Thermoplasmata	J	Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA	flpA	-	-	ko:K04795	-	-	-	-	ko00000,ko03009	-	-	-	Fibrillarin
MMS3_k127_2735458_3	273075.Ta0849	3.189e-248	795.0	COG0013@1|root,arCOG01255@2157|Archaea,2XSXB@28890|Euryarchaeota,241UG@183967|Thermoplasmata	183967|Thermoplasmata	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2c,tRNA_SAD
MMS3_k127_2735458_43	273075.Ta0839	2.806e-78	283.0	COG0750@1|root,arCOG00609@2157|Archaea,2Y3DV@28890|Euryarchaeota,2425X@183967|Thermoplasmata	183967|Thermoplasmata	M	membrane-associated Zn-dependent proteases 1	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_2735458_42	263820.PTO1093	9.433e-79	275.0	COG3199@1|root,arCOG01350@2157|Archaea,2XUIQ@28890|Euryarchaeota,241ZX@183967|Thermoplasmata	183967|Thermoplasmata	S	ATP-NAD kinase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_kinase
MMS3_k127_2735458_28	273116.14324767	3.777e-114	389.0	COG3356@1|root,arCOG04351@2157|Archaea,2XVEY@28890|Euryarchaeota,2421B@183967|Thermoplasmata	183967|Thermoplasmata	S	Predicted membrane protein (DUF2070)	-	-	-	ko:K08979	-	-	-	-	ko00000	-	-	-	DUF2070
MMS3_k127_2735458_25	273075.Ta0824	5.761e-123	404.0	COG0082@1|root,arCOG04133@2157|Archaea,2XT26@28890|Euryarchaeota,241MM@183967|Thermoplasmata	183967|Thermoplasmata	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	-	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
MMS3_k127_2735458_2	273075.Ta1081	1.391e-307	953.0	COG0466@1|root,arCOG02160@2157|Archaea,2XTT0@28890|Euryarchaeota,241JF@183967|Thermoplasmata	183967|Thermoplasmata	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Degrades polypeptides processively	-	-	3.4.21.53	ko:K04076	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AAA_32,Lon_C,Mg_chelatase
MMS3_k127_2735458_92	273075.Ta1609	0.0002776	49.0	COG1617@1|root,arCOG02197@2157|Archaea,2Y61S@28890|Euryarchaeota,242G0@183967|Thermoplasmata	183967|Thermoplasmata	S	KEOPS complex Cgi121-like subunit	-	-	-	ko:K09119	-	-	-	-	ko00000,ko03016	-	-	-	-
MMS3_k127_2735458_50	263820.PTO1237	3.498e-70	247.0	COG0524@1|root,arCOG00014@2157|Archaea,2Y65P@28890|Euryarchaeota,241U0@183967|Thermoplasmata	183967|Thermoplasmata	F	pfkB family carbohydrate kinase	-	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0004001,GO:0005488,GO:0005524,GO:0005525,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006213,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008617,GO:0008906,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009129,GO:0009130,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009224,GO:0009259,GO:0009260,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0034404,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042278,GO:0042455,GO:0043167,GO:0043168,GO:0043771,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046033,GO:0046035,GO:0046085,GO:0046087,GO:0046102,GO:0046128,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901068,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659,GO:1905108	2.7.1.213,2.7.1.73	ko:K22026	ko00230,ko00240,map00230,map00240	-	R00513,R01131,R01228	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
MMS3_k127_2735458_45	273116.14325248	4.632e-75	257.0	COG0663@1|root,arCOG01849@2157|Archaea,2XWNM@28890|Euryarchaeota	28890|Euryarchaeota	S	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep,Hexapep_2
MMS3_k127_2735458_16	273116.14325249	4.974e-151	488.0	COG0148@1|root,arCOG01169@2157|Archaea,2XSXT@28890|Euryarchaeota,241N7@183967|Thermoplasmata	183967|Thermoplasmata	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
MMS3_k127_2735458_60	273075.Ta0883	2.553e-49	185.0	COG1798@1|root,arCOG04161@2157|Archaea,2XV63@28890|Euryarchaeota,241UB@183967|Thermoplasmata	183967|Thermoplasmata	J	S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF- 2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis	dphB	-	2.1.1.98	ko:K20215	-	-	R04481,R08468,R08469,R10306	RC00003,RC00190,RC01155,RC02136,RC02308	ko00000,ko01000	-	-	-	TP_methylase
MMS3_k127_2735458_6	1051632.TPY_3362	5.128e-196	627.0	COG1053@1|root,COG1053@2|Bacteria,1TPAR@1239|Firmicutes,247SY@186801|Clostridia,3WD2K@538999|Clostridiales incertae sedis	186801|Clostridia	C	succinate dehydrogenase or fumarate reductase, flavoprotein subunitGram-negative mitochondrial subgroup	-	-	1.3.5.1,1.3.5.4	ko:K00239,ko:K00244	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,ko05134,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020,map05134	M00009,M00011,M00149,M00150,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
MMS3_k127_2735458_40	1379698.RBG1_1C00001G0452	7.024e-86	290.0	COG0479@1|root,COG0479@2|Bacteria,2NPY8@2323|unclassified Bacteria	2|Bacteria	C	TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein	sdhB1	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv0247c	Fer2_3,Fer4_8
MMS3_k127_2735458_66	266117.Rxyl_0010	7.217e-37	149.0	2CEY7@1|root,2Z8CG@2|Bacteria,2GKI0@201174|Actinobacteria	201174|Actinobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_2735458_88	443143.GM18_3996	1.584e-09	62.0	COG3464@1|root,COG3464@2|Bacteria,1MV5J@1224|Proteobacteria,42M93@68525|delta/epsilon subdivisions,2WK5I@28221|Deltaproteobacteria,43TTE@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	PFAM transposase IS204 IS1001 IS1096 IS1165 family protein	-	-	-	ko:K07485	-	-	-	-	ko00000	-	-	-	DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3
MMS3_k127_2850714_0	880073.Calab_1107	3.864e-116	401.0	COG1529@1|root,COG1529@2|Bacteria,2NPHP@2323|unclassified Bacteria	2|Bacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	1.17.1.4	ko:K11177	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2,Fer2_2
MMS3_k127_2850714_2	66377.JOBH01000008_gene6599	1.368e-44	166.0	COG2080@1|root,COG2080@2|Bacteria,2GMYH@201174|Actinobacteria	201174|Actinobacteria	C	Aerobic-type carbon monoxide dehydrogenase small subunit CoxS	coxS_1	-	-	ko:K13483	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002	-	-	-	Fer2,Fer2_2
MMS3_k127_2850714_1	644966.Tmar_1492	9.61e-47	180.0	COG1319@1|root,COG1319@2|Bacteria,1TQA5@1239|Firmicutes,248WI@186801|Clostridia	186801|Clostridia	C	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM	-	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
MMS3_k127_2850714_3	1138822.PL11_05875	0.0001057	53.0	COG4934@1|root,COG4934@2|Bacteria,1V06T@1239|Firmicutes,4HFKG@91061|Bacilli,3F47I@33958|Lactobacillaceae	91061|Bacilli	O	Pro-kumamolisin, activation domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8,Pro-kuma_activ
MMS3_k127_2861938_16	1172185.KB911509_gene514	1.81e-11	74.0	COG3214@1|root,COG3214@2|Bacteria,2GK0T@201174|Actinobacteria,4FVI4@85025|Nocardiaceae	201174|Actinobacteria	S	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_42
MMS3_k127_2861938_4	1408473.JHXO01000005_gene1726	1.263e-74	254.0	COG2818@1|root,COG2818@2|Bacteria,4NGRC@976|Bacteroidetes,2FN7E@200643|Bacteroidia	976|Bacteroidetes	L	DNA-3-methyladenine glycosylase	tag	-	3.2.2.20	ko:K01246	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Adenine_glyco
MMS3_k127_2861938_2	272844.PAB0762	8.709e-106	365.0	COG1505@1|root,arCOG01647@2157|Archaea,2XTRD@28890|Euryarchaeota,243RD@183968|Thermococci	183968|Thermococci	E	Prolyl oligopeptidase, N-terminal beta-propeller domain	-	-	3.4.21.26	ko:K01322	ko04614,map04614	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
MMS3_k127_2861938_11	273075.Ta1118	1.022e-35	141.0	arCOG06011@1|root,arCOG06011@2157|Archaea	2157|Archaea	S	Domain of unknown function (DUF4382)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4382
MMS3_k127_2861938_3	273116.14324523	3.996e-88	296.0	COG1500@1|root,arCOG04187@2157|Archaea,2XTNH@28890|Euryarchaeota,241NS@183967|Thermoplasmata	183967|Thermoplasmata	J	Shwachman-Bodian-Diamond syndrome (SBDS) protein	-	-	-	ko:K14574	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	SBDS,SBDS_C
MMS3_k127_2861938_8	273075.Ta0277	8.878e-68	234.0	COG0454@1|root,arCOG00826@2157|Archaea,2Y888@28890|Euryarchaeota,2426C@183967|Thermoplasmata	183967|Thermoplasmata	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
MMS3_k127_2861938_12	273075.Ta0278	3.996e-27	114.0	COG3388@1|root,arCOG01345@2157|Archaea,2XXVY@28890|Euryarchaeota,241VN@183967|Thermoplasmata	183967|Thermoplasmata	K	protein conserved in archaea	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_2861938_17	263820.PTO0699	4.807e-06	51.0	arCOG10671@1|root,arCOG10671@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_2861938_0	439481.Aboo_0966	1.386e-158	516.0	COG1690@1|root,arCOG04246@2157|Archaea,2XTIC@28890|Euryarchaeota,3F2GK@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	tRNA-splicing ligase RtcB	rtcB	GO:0000166,GO:0000394,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003972,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008380,GO:0008452,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016886,GO:0017076,GO:0019001,GO:0019002,GO:0030145,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901363	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Intein_splicing,LAGLIDADG_3,RtcB
MMS3_k127_2861938_1	273116.14325583	6.93e-128	445.0	arCOG07368@1|root,arCOG07368@2157|Archaea,2XZV6@28890|Euryarchaeota,242AS@183967|Thermoplasmata	183967|Thermoplasmata	S	CARDB	-	-	-	-	-	-	-	-	-	-	-	-	CARDB
MMS3_k127_2861938_14	273075.Ta1355	2.654e-14	79.0	arCOG07410@1|root,arCOG07410@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_2861938_5	263820.PTO0845	4.948e-73	252.0	COG0036@1|root,arCOG05046@2157|Archaea,2XVS8@28890|Euryarchaeota,241QM@183967|Thermoplasmata	183967|Thermoplasmata	G	Ribulose-phosphate 3 epimerase family	-	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
MMS3_k127_2861938_7	517418.Ctha_0729	1.808e-68	243.0	COG1090@1|root,COG1090@2|Bacteria,1FDN7@1090|Chlorobi	1090|Chlorobi	S	PFAM NAD-dependent epimerase dehydratase	-	-	-	ko:K07071	-	-	-	-	ko00000	-	-	-	DUF1731,Epimerase
MMS3_k127_2861938_10	1237149.C900_04763	7.517e-38	146.0	COG0346@1|root,COG0346@2|Bacteria,4NN6H@976|Bacteroidetes,47SAE@768503|Cytophagia	976|Bacteroidetes	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	ko:K07032	-	-	-	-	ko00000	-	-	-	Glyoxalase
MMS3_k127_2861938_15	1229520.ADIAL_0341	4.484e-12	74.0	COG1136@1|root,COG1136@2|Bacteria,1TQP5@1239|Firmicutes,4HBXK@91061|Bacilli,27G0W@186828|Carnobacteriaceae	91061|Bacilli	V	ATPases associated with a variety of cellular activities	lolD	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
MMS3_k127_2861938_9	399549.Msed_1781	1.209e-61	222.0	COG0555@1|root,arCOG00164@2157|Archaea,2XQTS@28889|Crenarchaeota	28889|Crenarchaeota	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K15496	ko02010,map02010	M00423	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.5	-	-	BPD_transp_1
MMS3_k127_2861938_6	671065.MetMK1DRAFT_00023960	9.813e-72	254.0	COG0725@1|root,arCOG00219@2157|Archaea,2XR4G@28889|Crenarchaeota	28889|Crenarchaeota	P	ABC-type molybdate transport system periplasmic	-	-	-	ko:K15495	ko02010,map02010	M00423	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.5	-	-	SBP_bac_11
MMS3_k127_2861938_13	579137.Metvu_1665	8.424e-17	86.0	COG1356@1|root,arCOG04554@2157|Archaea,2XXGH@28890|Euryarchaeota,23QZC@183939|Methanococci	183939|Methanococci	K	transcriptional regulatory protein	-	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141	-	ko:K09714	-	-	-	-	ko00000	-	-	-	Sigma70_r4,TFX_C
MMS3_k127_2935783_22	273063.STK_18005	1.673e-07	55.0	arCOG02218@1|root,arCOG02218@2157|Archaea,2XRHK@28889|Crenarchaeota	28889|Crenarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	CcdA
MMS3_k127_2935783_19	490899.DKAM_1281	1.974e-17	86.0	COG4113@1|root,arCOG00729@2157|Archaea,2XQZE@28889|Crenarchaeota	28889|Crenarchaeota	V	nucleic acid-binding protein contains PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
MMS3_k127_2935783_21	416348.Hlac_1082	1.47e-11	70.0	COG2402@1|root,arCOG04502@2157|Archaea,2XXE8@28890|Euryarchaeota,23VKJ@183963|Halobacteria	183963|Halobacteria	V	nucleic acid-binding protein, contains PIN domain	-	-	-	ko:K07065	-	-	-	-	ko00000	-	-	-	PIN
MMS3_k127_2935783_8	273075.Ta0989	1.365e-69	243.0	COG0639@1|root,arCOG01143@2157|Archaea,2XUDG@28890|Euryarchaeota	28890|Euryarchaeota	T	COG0639 Diadenosine tetraphosphatase and related serine threonine protein phosphatases	-	-	3.1.3.16	ko:K01090	-	-	-	-	ko00000,ko01000	-	-	-	Metallophos_2
MMS3_k127_2935783_14	273075.Ta0472	3.604e-38	150.0	COG1777@1|root,arCOG01684@2157|Archaea,2Y680@28890|Euryarchaeota,241VW@183967|Thermoplasmata	183967|Thermoplasmata	K	transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
MMS3_k127_2935783_13	273075.Ta0471	9.273e-49	180.0	COG0071@1|root,arCOG01832@2157|Archaea,2Y89K@28890|Euryarchaeota,242IE@183967|Thermoplasmata	183967|Thermoplasmata	O	Hsp20/alpha crystallin family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
MMS3_k127_2935783_10	263820.PTO1146	1.436e-66	233.0	COG0586@1|root,arCOG03117@2157|Archaea,2XY9U@28890|Euryarchaeota,242EE@183967|Thermoplasmata	183967|Thermoplasmata	S	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
MMS3_k127_2935783_4	273075.Ta0312	5.829e-84	281.0	COG2131@1|root,arCOG01487@2157|Archaea,2XXBC@28890|Euryarchaeota,241PS@183967|Thermoplasmata	183967|Thermoplasmata	F	MafB19-like deaminase	-	-	3.5.4.12	ko:K01493	ko00240,ko01100,map00240,map01100	M00429	R01663	RC00074	ko00000,ko00001,ko00002,ko01000,ko02044	-	-	-	dCMP_cyt_deam_1
MMS3_k127_2935783_17	351160.RCIX195	4.337e-29	130.0	COG0438@1|root,arCOG01403@2157|Archaea,2XUUY@28890|Euryarchaeota,2N99V@224756|Methanomicrobia	224756|Methanomicrobia	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
MMS3_k127_2935783_2	273116.14324742	1.324e-97	327.0	COG1131@1|root,arCOG00194@2157|Archaea,2Y39V@28890|Euryarchaeota,2422I@183967|Thermoplasmata	183967|Thermoplasmata	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
MMS3_k127_2935783_11	933801.Ahos_0106	4.605e-54	198.0	COG0842@1|root,arCOG01469@2157|Archaea,2XRBH@28889|Crenarchaeota	28889|Crenarchaeota	P	ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
MMS3_k127_2935783_23	765177.Desmu_0521	0.0003039	53.0	COG1277@1|root,arCOG02441@2157|Archaea,2XQE4@28889|Crenarchaeota	28889|Crenarchaeota	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
MMS3_k127_2935783_6	591019.Shell_0704	2.033e-78	272.0	COG1131@1|root,arCOG00194@2157|Archaea,2XPNB@28889|Crenarchaeota	28889|Crenarchaeota	V	PFAM ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
MMS3_k127_2935783_0	273075.Ta1287	4.142e-141	461.0	COG0477@1|root,arCOG02683@2157|Archaea	2157|Archaea	EGP	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	Sugar_tr
MMS3_k127_2935783_7	397948.Cmaq_0187	1.37e-71	248.0	COG1584@1|root,arCOG03176@2157|Archaea	2157|Archaea	S	GPR1 FUN34 yaaH family	-	-	-	ko:K07034	-	-	-	-	ko00000	-	-	-	Grp1_Fun34_YaaH
MMS3_k127_2935783_15	747365.Thena_1368	5.823e-36	139.0	COG2920@1|root,COG2920@2|Bacteria,1V6WF@1239|Firmicutes,24JRH@186801|Clostridia,42GKQ@68295|Thermoanaerobacterales	186801|Clostridia	P	TIGRFAM sulfur relay protein, TusE DsrC DsvC family	-	-	-	ko:K11179	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DsrC
MMS3_k127_2935783_9	397948.Cmaq_0853	3.24e-68	247.0	COG2221@1|root,arCOG02057@2157|Archaea	2157|Archaea	C	PFAM nitrite and sulphite reductase 4Fe-4S	-	GO:0005575,GO:0016020	1.8.99.5	ko:K11180	ko00633,ko00920,ko01100,ko01120,map00633,map00920,map01100,map01120	M00596	R00295,R00861,R08035	RC00065,RC01760	ko00000,ko00001,ko00002,ko01000	-	-	-	NIR_SIR,NIR_SIR_ferr
MMS3_k127_2935783_5	572478.Vdis_2099	7.561e-83	287.0	COG2221@1|root,arCOG02059@2157|Archaea	2157|Archaea	C	Nitrite sulfite reductase, hemoprotein beta-component, ferrodoxin domain protein	-	GO:0003674,GO:0003824,GO:0005575,GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0016002,GO:0016020,GO:0016491,GO:0016667,GO:0016673,GO:0019419,GO:0044237,GO:0050311,GO:0055114	1.8.99.5	ko:K11181	ko00633,ko00920,ko01100,ko01120,map00633,map00920,map01100,map01120	M00596	R00295,R00861,R08035	RC00065,RC01760	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,NIR_SIR,NIR_SIR_ferr
MMS3_k127_2935783_20	138119.DSY0312	4.392e-15	84.0	COG2181@1|root,COG2181@2|Bacteria,1UYRK@1239|Firmicutes,24FM8@186801|Clostridia,266ZT@186807|Peptococcaceae	186801|Clostridia	C	PFAM Nitrate reductase gamma subunit	hmeC	-	-	-	-	-	-	-	-	-	-	-	Nitrate_red_gam
MMS3_k127_2935783_1	397948.Cmaq_0851	2.126e-130	431.0	COG0247@1|root,arCOG00333@2157|Archaea,2XPX6@28889|Crenarchaeota	28889|Crenarchaeota	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
MMS3_k127_2935783_16	273063.STK_06160	9.084e-30	122.0	COG2210@1|root,arCOG02065@2157|Archaea	2157|Archaea	S	DsrE/DsrF-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE
MMS3_k127_2935783_12	621372.ACIH01000144_gene162	8.466e-51	189.0	COG0007@1|root,COG1587@1|root,COG0007@2|Bacteria,COG1587@2|Bacteria,1TQNH@1239|Firmicutes,4HBB7@91061|Bacilli,26R9W@186822|Paenibacillaceae	91061|Bacilli	H	Belongs to the precorrin methyltransferase family	hemX	-	2.1.1.107,4.2.1.75	ko:K02303,ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165,R03194	RC00003,RC00871,RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4,TP_methylase
MMS3_k127_2935783_18	269797.Mbar_A1461	1.285e-18	93.0	COG1648@1|root,arCOG01044@2157|Archaea,2XWMY@28890|Euryarchaeota,2N9U9@224756|Methanomicrobia	224756|Methanomicrobia	H	TIGRFAM siroheme synthase	cysG	GO:0003674,GO:0003824,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0016628,GO:0018130,GO:0019354,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043115,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	1.3.1.76,4.99.1.4	ko:K02304	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03947	RC01012,RC01034	ko00000,ko00001,ko00002,ko01000	-	-	-	NAD_binding_7,Sirohm_synth_M
MMS3_k127_2935783_3	273075.Ta0365	1.329e-85	299.0	COG0582@1|root,arCOG01241@2157|Archaea,2XWM9@28890|Euryarchaeota	28890|Euryarchaeota	L	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_2945540_7	397948.Cmaq_1232	1.809e-21	97.0	COG2377@1|root,2N56F@2157|Archaea	2157|Archaea	O	Anhydro-N-acetylmuramic acid kinase	-	-	2.7.1.170	ko:K09001	-	-	-	-	ko00000,ko01000	-	-	-	AnmK
MMS3_k127_2945540_8	28444.JODQ01000007_gene5149	2.229e-17	96.0	COG0747@1|root,COG0747@2|Bacteria,2IA6M@201174|Actinobacteria,4EKPC@85012|Streptosporangiales	201174|Actinobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
MMS3_k127_2945540_3	525909.Afer_0172	6.43e-75	263.0	COG0601@1|root,COG0601@2|Bacteria,2GM72@201174|Actinobacteria,4CNNT@84992|Acidimicrobiia	84992|Acidimicrobiia	U	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
MMS3_k127_2945540_4	324057.Pjdr2_4154	4.43e-65	233.0	COG1173@1|root,COG1173@2|Bacteria,1TP4R@1239|Firmicutes,4HA7I@91061|Bacilli,26QGW@186822|Paenibacillaceae	91061|Bacilli	P	Peptide ABC transporter permease	oppC1	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
MMS3_k127_2945540_1	479432.Sros_7459	4.664e-77	269.0	COG0444@1|root,COG0444@2|Bacteria,2GIXV@201174|Actinobacteria,4EFUM@85012|Streptosporangiales	201174|Actinobacteria	EP	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
MMS3_k127_2945540_2	1042877.GQS_09880	3.671e-76	267.0	COG4608@1|root,arCOG00184@2157|Archaea,2Y5BH@28890|Euryarchaeota,243RX@183968|Thermococci	183968|Thermococci	E	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
MMS3_k127_2945540_9	263820.PTO0023	8.56e-11	69.0	arCOG08351@1|root,arCOG08351@2157|Archaea,2XZR4@28890|Euryarchaeota	28890|Euryarchaeota	S	DUF218 domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF218
MMS3_k127_2945540_6	572547.Amico_1651	5.55e-36	147.0	COG2362@1|root,COG2362@2|Bacteria,3TAU4@508458|Synergistetes	508458|Synergistetes	E	PFAM peptidase M55 D-aminopeptidase	-	-	-	ko:K16203	-	-	-	-	ko00000,ko01000,ko01002	3.A.1.5.2	-	-	Peptidase_M55
MMS3_k127_2945540_5	263820.PTO0015	1.297e-37	156.0	COG2027@1|root,arCOG06756@2157|Archaea	2157|Archaea	M	D-alanyl-D-alanine carboxypeptidase	-	-	3.4.16.4	ko:K07259	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	Peptidase_S13
MMS3_k127_2945540_0	263820.PTO0016	2.934e-99	338.0	COG0019@1|root,arCOG02268@2157|Archaea,2XSY8@28890|Euryarchaeota,241ND@183967|Thermoplasmata	183967|Thermoplasmata	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
MMS3_k127_29549_31	485913.Krac_1566	8.756e-35	144.0	COG3177@1|root,COG3177@2|Bacteria,2G7KD@200795|Chloroflexi	200795|Chloroflexi	S	Fic/DOC family	-	-	-	-	-	-	-	-	-	-	-	-	Fic
MMS3_k127_29549_12	1343739.PAP_01865	2.157e-122	407.0	COG1249@1|root,arCOG01068@2157|Archaea,2XTXN@28890|Euryarchaeota	28890|Euryarchaeota	C	COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes	pdhD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	1.8.1.4,1.8.1.7	ko:K00382,ko:K00383	ko00010,ko00020,ko00260,ko00280,ko00480,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04918,map00010,map00020,map00260,map00280,map00480,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200,map04918	M00009,M00011,M00036,M00307,M00532	R00094,R00115,R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00011,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iAF692.Mbar_A3561	Pyr_redox_2,Pyr_redox_dim
MMS3_k127_29549_30	263820.PTO0905	9.531e-36	142.0	COG1628@1|root,arCOG00928@2157|Archaea,2Y65C@28890|Euryarchaeota,242EF@183967|Thermoplasmata	183967|Thermoplasmata	L	Protein of unknown function DUF99	-	-	-	ko:K09120	-	-	-	-	ko00000	-	-	-	DUF99
MMS3_k127_29549_29	263820.PTO0526	4.048e-37	142.0	arCOG02738@1|root,arCOG02738@2157|Archaea,2Y4Q5@28890|Euryarchaeota,242E8@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_29549_6	273116.14324379	1.261e-144	465.0	COG0150@1|root,arCOG00639@2157|Archaea,2XTBA@28890|Euryarchaeota,241K3@183967|Thermoplasmata	183967|Thermoplasmata	F	phosphoribosylformylglycinamidine cyclo-ligase activity	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
MMS3_k127_29549_24	273116.14324334	3.711e-70	239.0	COG1146@1|root,arCOG04548@2157|Archaea,2XXXG@28890|Euryarchaeota,2426K@183967|Thermoplasmata	183967|Thermoplasmata	C	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
MMS3_k127_29549_37	273116.14325603	8.305e-07	59.0	arCOG07367@1|root,arCOG07367@2157|Archaea	2157|Archaea	-	-	-	-	3.4.23.52	ko:K07991	-	-	-	-	ko00000,ko01000,ko01002,ko02035,ko02044	-	-	-	-
MMS3_k127_29549_21	263820.PTO0105	2.061e-82	288.0	COG1228@1|root,arCOG00696@2157|Archaea,2XUHH@28890|Euryarchaeota,241YC@183967|Thermoplasmata	183967|Thermoplasmata	F	imidazolonepropionase activity	hutI	-	3.5.2.7	ko:K01468	ko00340,ko01100,map00340,map01100	M00045	R02288	RC00683	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
MMS3_k127_29549_13	263820.PTO0430	1.527e-111	369.0	COG1736@1|root,arCOG04112@2157|Archaea,2XSY5@28890|Euryarchaeota,241PJ@183967|Thermoplasmata	183967|Thermoplasmata	J	Putative diphthamide synthesis protein	-	-	2.5.1.108	ko:K07561	-	-	R10455	RC00021,RC03180	ko00000,ko01000,ko03012	-	-	-	Diphthamide_syn
MMS3_k127_29549_10	263820.PTO0429	5.701e-136	444.0	COG0621@1|root,arCOG01358@2157|Archaea,2XSVB@28890|Euryarchaeota,241MG@183967|Thermoplasmata	183967|Thermoplasmata	J	Uncharacterized protein family UPF0004	-	-	2.8.4.5	ko:K15865	-	-	R10649	RC00003,RC03221	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,UPF0004
MMS3_k127_29549_1	273075.Ta0258	1.395e-199	630.0	COG1027@1|root,arCOG01750@2157|Archaea,2Y84P@28890|Euryarchaeota,2422A@183967|Thermoplasmata	183967|Thermoplasmata	E	Fumarase C C-terminus	-	-	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
MMS3_k127_29549_0	273116.14325598	5.019e-253	792.0	COG0674@1|root,arCOG01606@2157|Archaea,2XSUJ@28890|Euryarchaeota,241S7@183967|Thermoplasmata	183967|Thermoplasmata	C	Pyruvate:ferredoxin oxidoreductase core domain II	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
MMS3_k127_29549_11	263820.PTO1361	2.43e-124	404.0	COG1013@1|root,arCOG01599@2157|Archaea,2XTW2@28890|Euryarchaeota,241Y9@183967|Thermoplasmata	183967|Thermoplasmata	C	Pyruvate ferredoxin oxidoreductase beta subunit C terminal	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFO_beta_C,TPP_enzyme_C
MMS3_k127_29549_15	273116.14325594	2.46e-108	361.0	COG0601@1|root,arCOG00751@2157|Archaea,2XTRU@28890|Euryarchaeota	28890|Euryarchaeota	P	ABC-type dipeptide oligopeptide nickel transport systems, permease components	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
MMS3_k127_29549_20	273116.14325593	5.19e-92	313.0	COG1173@1|root,arCOG00748@2157|Archaea,2XUIX@28890|Euryarchaeota	28890|Euryarchaeota	P	ABC-type dipeptide oligopeptide nickel transport systems, permease components	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
MMS3_k127_29549_3	273116.14325592	1.551e-158	515.0	COG0444@1|root,arCOG00181@2157|Archaea,2XSTM@28890|Euryarchaeota	28890|Euryarchaeota	E	COG0444 ABC-type dipeptide oligopeptide nickel transport system ATPase component	oppD2	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
MMS3_k127_29549_2	273116.14325591	1.22e-160	520.0	COG4608@1|root,arCOG00184@2157|Archaea,2Y5BH@28890|Euryarchaeota	28890|Euryarchaeota	E	COG4608 ABC-type oligopeptide transport system, ATPase component	-	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
MMS3_k127_29549_18	263820.PTO0517	4.165e-102	334.0	COG0052@1|root,arCOG04245@2157|Archaea,2XTHM@28890|Euryarchaeota,241MQ@183967|Thermoplasmata	183967|Thermoplasmata	J	Belongs to the universal ribosomal protein uS2 family	rps2	-	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
MMS3_k127_29549_33	263820.PTO0518	1.01e-25	118.0	COG1676@1|root,arCOG01701@2157|Archaea,2Y6AD@28890|Euryarchaeota,241VY@183967|Thermoplasmata	183967|Thermoplasmata	J	Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp (By similarity)	endA	-	4.6.1.16	ko:K01170	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_int_endo
MMS3_k127_29549_39	5722.XP_001319879.1	9.79e-05	51.0	KOG0094@1|root,KOG0094@2759|Eukaryota	5722.XP_001319879.1|-	S	retrograde vesicle-mediated transport, Golgi to ER	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_29549_4	273116.14324619	5.664e-148	479.0	COG1167@1|root,arCOG00492@2157|Archaea,2XVD6@28890|Euryarchaeota,241ZA@183967|Thermoplasmata	183967|Thermoplasmata	E	Aminotransferase class I and II	-	-	-	ko:K05825	ko00300,ko01100,ko01130,ko01210,map00300,map01100,map01130,map01210	-	R01939	RC00006	ko00000,ko00001,ko01000	-	-	-	Aminotran_1_2
MMS3_k127_29549_22	273116.14324620	7.444e-72	254.0	COG1986@1|root,arCOG01221@2157|Archaea,2Y898@28890|Euryarchaeota,241PH@183967|Thermoplasmata	183967|Thermoplasmata	F	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	GO:0003674,GO:0003824,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111	2.7.7.3	ko:K02201	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like,NTPase_I-T
MMS3_k127_29549_26	263820.PTO0507	6.769e-51	181.0	COG2151@1|root,arCOG01845@2157|Archaea,2Y0P6@28890|Euryarchaeota,242AR@183967|Thermoplasmata	183967|Thermoplasmata	S	Pfam:DUF59	-	-	-	-	-	-	-	-	-	-	-	-	FeS_assembly_P
MMS3_k127_29549_19	273116.14325659	1.374e-101	332.0	COG2101@1|root,arCOG01764@2157|Archaea,2XTTR@28890|Euryarchaeota,241NQ@183967|Thermoplasmata	183967|Thermoplasmata	K	General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation	tbp	-	-	ko:K03120	ko03022,ko05016,ko05165,ko05166,ko05168,ko05169,ko05203,map03022,map05016,map05165,map05166,map05168,map05169,map05203	-	-	-	ko00000,ko00001,ko03000,ko03021	-	-	-	TBP
MMS3_k127_29549_14	263820.PTO0505	7.642e-109	365.0	COG0585@1|root,arCOG04252@2157|Archaea,2XUTK@28890|Euryarchaeota,241NZ@183967|Thermoplasmata	183967|Thermoplasmata	J	Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs	truD	-	5.4.99.27	ko:K06176	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruD
MMS3_k127_29549_16	1229909.NSED_02810	1.251e-106	357.0	COG1060@1|root,arCOG00656@2157|Archaea,41SCN@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnC	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
MMS3_k127_29549_7	273075.Ta0217	7.753e-142	459.0	COG1060@1|root,arCOG00656@2157|Archaea,2XW63@28890|Euryarchaeota	28890|Euryarchaeota	H	Radical SAM domain protein	-	-	2.5.1.120	ko:K18285	ko00130,ko01110,map00130,map01110	-	R10667	RC00021,RC03234	ko00000,ko00001,ko01000	-	-	-	Radical_SAM
MMS3_k127_29549_8	263820.PTO1245	3.526e-141	482.0	COG0210@1|root,arCOG00798@2157|Archaea,2Y7QM@28890|Euryarchaeota,2420G@183967|Thermoplasmata	183967|Thermoplasmata	L	UvrD/REP helicase N-terminal domain	-	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
MMS3_k127_29549_35	273116.14324513	1.012e-19	90.0	COG1522@1|root,arCOG01117@2157|Archaea,2Y6GC@28890|Euryarchaeota,242F4@183967|Thermoplasmata	183967|Thermoplasmata	K	Lrp/AsnC ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
MMS3_k127_29549_27	224719.Abm4_0488	7.34e-44	167.0	COG2078@1|root,arCOG01336@2157|Archaea,2XUAP@28890|Euryarchaeota,23PJV@183925|Methanobacteria	183925|Methanobacteria	S	AMMECR1	-	-	-	ko:K09141	-	-	-	-	ko00000	-	-	-	AMMECR1
MMS3_k127_29549_25	263820.PTO0958	1.21e-62	225.0	COG1355@1|root,arCOG01728@2157|Archaea,2XVYU@28890|Euryarchaeota,241T1@183967|Thermoplasmata	183967|Thermoplasmata	S	Memo-like protein	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
MMS3_k127_29549_5	273116.14325615	5.475e-147	471.0	COG1180@1|root,arCOG00946@2157|Archaea,2XUB7@28890|Euryarchaeota,241PG@183967|Thermoplasmata	183967|Thermoplasmata	C	Elongator protein 3, MiaB family, Radical SAM	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Radical_SAM
MMS3_k127_29549_23	1041930.Mtc_1660	1.069e-70	250.0	COG0265@1|root,arCOG02833@2157|Archaea,2XT7Y@28890|Euryarchaeota,2NAWS@224756|Methanomicrobia	224756|Methanomicrobia	O	Trypsin	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
MMS3_k127_29549_36	485913.Krac_0590	2.671e-14	77.0	COG1733@1|root,COG1733@2|Bacteria	2|Bacteria	K	regulation of RNA biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
MMS3_k127_29549_34	268407.PWYN_17460	6.196e-25	114.0	COG0842@1|root,COG0842@2|Bacteria,1V13R@1239|Firmicutes,4HD1H@91061|Bacilli,26U7M@186822|Paenibacillaceae	91061|Bacilli	V	ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
MMS3_k127_29549_32	1476876.JOJO01000012_gene4156	4.625e-28	123.0	COG0842@1|root,COG0842@2|Bacteria,2HDDD@201174|Actinobacteria	201174|Actinobacteria	V	ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
MMS3_k127_29549_17	1157632.AQWQ01000003_gene2066	1.313e-102	343.0	COG1131@1|root,COG1131@2|Bacteria,2GTNE@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
MMS3_k127_29549_28	1172180.KB911777_gene1804	2.405e-41	160.0	COG1247@1|root,COG1247@2|Bacteria,2II0A@201174|Actinobacteria	201174|Actinobacteria	M	-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_29549_9	1121472.AQWN01000004_gene802	1.524e-137	448.0	COG0004@1|root,COG0004@2|Bacteria,1TQYG@1239|Firmicutes,247W1@186801|Clostridia,2603A@186807|Peptococcaceae	186801|Clostridia	U	TIGRFAM Ammonium transporter	nrgA	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
MMS3_k127_29549_38	398720.MED217_11084	2.243e-06	56.0	COG0454@1|root,COG0456@2|Bacteria,4PE0E@976|Bacteroidetes,1IEEA@117743|Flavobacteriia,2XK0J@283735|Leeuwenhoekiella	976|Bacteroidetes	K	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
MMS3_k127_33093_25	634956.Geoth_2534	4.787e-85	297.0	COG0477@1|root,COG2814@2|Bacteria,1TQM0@1239|Firmicutes,4HATA@91061|Bacilli,1WHZ9@129337|Geobacillus	91061|Bacilli	P	Sugar (and other) transporter	-	-	-	ko:K08368,ko:K08369	-	-	-	-	ko00000,ko02000	2.A.1	-	-	MFS_1,Sugar_tr
MMS3_k127_33093_58	273075.Ta0887	1.91e-25	115.0	COG0596@1|root,arCOG01648@2157|Archaea,2Y72P@28890|Euryarchaeota,2428V@183967|Thermoplasmata	183967|Thermoplasmata	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
MMS3_k127_33093_31	397948.Cmaq_0187	6.993e-72	248.0	COG1584@1|root,arCOG03176@2157|Archaea	2157|Archaea	S	GPR1 FUN34 yaaH family	-	-	-	ko:K07034	-	-	-	-	ko00000	-	-	-	Grp1_Fun34_YaaH
MMS3_k127_33093_44	1459636.NTE_03133	1.569e-44	174.0	COG0640@1|root,COG1809@1|root,arCOG00394@2157|Archaea,arCOG04896@2157|Archaea	2157|Archaea	K	PFAM (2R)-phospho-3-sulfolactate synthase ComA	comA	GO:0003674,GO:0003824,GO:0016829,GO:0016830,GO:0016831,GO:0050545	4.4.1.19	ko:K08097	ko00680,ko01120,map00680,map01120	M00358	R07476	RC01799	ko00000,ko00001,ko00002,ko01000	-	-	-	ComA
MMS3_k127_33093_40	273075.Ta0674	2.484e-48	183.0	COG2017@1|root,arCOG05361@2157|Archaea	2157|Archaea	G	PFAM Aldose 1-epimerase	-	-	5.1.3.3	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	M00632	R01602,R10619	RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldose_epim
MMS3_k127_33093_21	273063.STK_22710	6.776e-96	324.0	COG2876@1|root,arCOG01049@2157|Archaea,2XQ1G@28889|Crenarchaeota	28889|Crenarchaeota	E	PFAM DAHP synthetase I	aroG	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
MMS3_k127_33093_51	263820.PTO0836	2.726e-30	128.0	COG0287@1|root,arCOG00256@2157|Archaea,2Y4RC@28890|Euryarchaeota,242D4@183967|Thermoplasmata	183967|Thermoplasmata	C	prephenate dehydrogenase (NADP+) activity	-	-	1.3.1.12	ko:K00210	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025	R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	-
MMS3_k127_33093_66	273075.Ta0245m	2.748e-11	72.0	COG1605@1|root,arCOG07365@2157|Archaea,2Y5S5@28890|Euryarchaeota,242F1@183967|Thermoplasmata	183967|Thermoplasmata	E	Chorismate mutase type II	-	-	-	-	-	-	-	-	-	-	-	-	CM_2
MMS3_k127_33093_16	1132509.C447_12120	1.468e-115	385.0	COG0141@1|root,arCOG04352@2157|Archaea,2XT6M@28890|Euryarchaeota,23UQF@183963|Halobacteria	183963|Halobacteria	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	-	-	1.1.1.308	ko:K15509	-	-	-	-	ko00000,ko01000	-	-	-	Histidinol_dh
MMS3_k127_33093_46	1056495.Calag_0179	1.707e-41	171.0	COG0531@1|root,arCOG03649@2157|Archaea,2XRR3@28889|Crenarchaeota	28889|Crenarchaeota	E	amino acid	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease
MMS3_k127_33093_72	1120956.JHZK01000003_gene401	4.491e-06	55.0	COG1522@1|root,COG1522@2|Bacteria,1RHP2@1224|Proteobacteria,2U6ES@28211|Alphaproteobacteria,1JNZR@119043|Rhodobiaceae	28211|Alphaproteobacteria	K	helix_turn_helix ASNC type	-	-	-	ko:K05800	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24
MMS3_k127_33093_60	330779.Saci_2136	1.511e-24	109.0	COG1522@1|root,arCOG01580@2157|Archaea	2157|Archaea	K	COG1522 Transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_24,HTH_IclR,TrmB
MMS3_k127_33093_19	985053.VMUT_1168	1.203e-109	369.0	COG0160@1|root,arCOG00915@2157|Archaea,2XPTE@28889|Crenarchaeota	28889|Crenarchaeota	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.19,2.6.1.76	ko:K00823,ko:K00836	ko00250,ko00260,ko00410,ko00640,ko00650,ko01100,ko01120,ko01210,ko01230,map00250,map00260,map00410,map00640,map00650,map01100,map01120,map01210,map01230	M00027,M00033	R00908,R01648,R06977	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
MMS3_k127_33093_62	387631.Asulf_01626	4.178e-21	105.0	COG0644@1|root,arCOG00570@2157|Archaea,2XU3J@28890|Euryarchaeota,245QU@183980|Archaeoglobi	183980|Archaeoglobi	C	Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains	-	-	1.3.1.101,1.3.7.11	ko:K17830	ko00564,map00564	-	R10325,R10326,R10331	RC03134	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3
MMS3_k127_33093_9	273116.14325545	4.764e-166	534.0	COG1012@1|root,arCOG01252@2157|Archaea,2XT1Y@28890|Euryarchaeota	28890|Euryarchaeota	C	Belongs to the aldehyde dehydrogenase family	gabD	-	1.2.1.16,1.2.1.20,1.2.1.79	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	M00027	R00713,R00714,R02401	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A2542	Aldedh
MMS3_k127_33093_49	316274.Haur_4401	3.02e-38	154.0	COG0596@1|root,COG0596@2|Bacteria,2G6VQ@200795|Chloroflexi	200795|Chloroflexi	S	PFAM alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
MMS3_k127_33093_24	273063.STK_18520	3.161e-85	296.0	arCOG03660@1|root,arCOG03660@2157|Archaea,2XRM5@28889|Crenarchaeota	28889|Crenarchaeota	G	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS3_k127_33093_57	397948.Cmaq_1581	2.966e-26	111.0	COG3370@1|root,arCOG01668@2157|Archaea,2XS6U@28889|Crenarchaeota	28889|Crenarchaeota	S	DsrE/DsrF-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE
MMS3_k127_33093_14	224325.AF_1191	6.12e-118	386.0	COG0447@1|root,arCOG00240@2157|Archaea,2XT32@28890|Euryarchaeota,247I7@183980|Archaeoglobi	183980|Archaeoglobi	H	Belongs to the enoyl-CoA hydratase isomerase family. MenB subfamily	menB	-	4.1.3.36	ko:K01661	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R07263	RC01923	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
MMS3_k127_33093_15	387631.Asulf_01198	9.523e-117	382.0	COG1250@1|root,arCOG00250@2157|Archaea,2XTMV@28890|Euryarchaeota	28890|Euryarchaeota	I	3-hydroxyacyl-CoA dehydrogenase	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
MMS3_k127_33093_70	273057.SSO3177	2.903e-07	60.0	arCOG06029@1|root,arCOG06029@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_33093_73	1443665.JACA01000005_gene524	1.169e-05	57.0	COG0457@1|root,COG4585@1|root,COG0457@2|Bacteria,COG4585@2|Bacteria,4NFNN@976|Bacteroidetes,1IINK@117743|Flavobacteriia,2YI2M@290174|Aquimarina	976|Bacteroidetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3,TPR_12,TPR_8
MMS3_k127_33093_8	632335.Calkr_0337	2.172e-188	606.0	COG1274@1|root,COG1274@2|Bacteria,1TQED@1239|Firmicutes,249NP@186801|Clostridia,42FYF@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle	pckG	-	4.1.1.32	ko:K01596	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964	M00003	R00431,R00726	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_C,PEPCK_N
MMS3_k127_33093_28	273116.14325593	5.939e-74	261.0	COG1173@1|root,arCOG00748@2157|Archaea,2XUIX@28890|Euryarchaeota	28890|Euryarchaeota	P	ABC-type dipeptide oligopeptide nickel transport systems, permease components	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
MMS3_k127_33093_41	273116.14325594	3.155e-48	187.0	COG0601@1|root,arCOG00751@2157|Archaea,2XTRU@28890|Euryarchaeota	28890|Euryarchaeota	P	ABC-type dipeptide oligopeptide nickel transport systems, permease components	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
MMS3_k127_33093_59	263820.PTO0975	8.212e-25	109.0	COG1694@1|root,arCOG01084@2157|Archaea,2XZ89@28890|Euryarchaeota,242EW@183967|Thermoplasmata	183967|Thermoplasmata	S	MazG-like family	-	-	-	-	-	-	-	-	-	-	-	-	MazG-like
MMS3_k127_33093_56	263820.PTO0494	2.057e-26	110.0	COG0636@1|root,arCOG02455@2157|Archaea,2Y1B9@28890|Euryarchaeota,242DV@183967|Thermoplasmata	183967|Thermoplasmata	C	ATP synthase subunit C	-	-	-	ko:K02124	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_C
MMS3_k127_33093_71	263820.PTO0493	2.783e-06	56.0	COG1390@1|root,arCOG00869@2157|Archaea,2Y7CD@28890|Euryarchaeota,242HT@183967|Thermoplasmata	183967|Thermoplasmata	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpE	-	-	ko:K02121	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	-
MMS3_k127_33093_22	273116.14324263	9.542e-90	307.0	COG1527@1|root,arCOG02459@2157|Archaea,2Y67I@28890|Euryarchaeota,24275@183967|Thermoplasmata	183967|Thermoplasmata	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	-	-	ko:K02119	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_AC39
MMS3_k127_33093_54	273116.14324264	6.128e-27	113.0	COG1436@1|root,arCOG04102@2157|Archaea,2Y5Y7@28890|Euryarchaeota,242ET@183967|Thermoplasmata	183967|Thermoplasmata	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpF	-	-	ko:K02122	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_F
MMS3_k127_33093_0	697281.Mahau_0630	0.0	1061.0	COG1155@1|root,COG1372@1|root,COG1155@2|Bacteria,COG1372@2|Bacteria,1TPGS@1239|Firmicutes,24882@186801|Clostridia,42ETB@68295|Thermoanaerobacterales	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit	atpA	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
MMS3_k127_33093_4	273116.14324266	1.485e-232	726.0	COG1156@1|root,arCOG00865@2157|Archaea,2XSYQ@28890|Euryarchaeota,241K0@183967|Thermoplasmata	183967|Thermoplasmata	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit	atpB	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
MMS3_k127_33093_34	273116.14324267	7.543e-66	231.0	COG1394@1|root,arCOG04101@2157|Archaea,2XTQ5@28890|Euryarchaeota,241TN@183967|Thermoplasmata	183967|Thermoplasmata	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpD	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
MMS3_k127_33093_10	273116.14324269	1.665e-161	530.0	COG1269@1|root,arCOG04138@2157|Archaea,2XTQP@28890|Euryarchaeota,241UP@183967|Thermoplasmata	183967|Thermoplasmata	C	V-type ATPase 116kDa subunit family	-	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
MMS3_k127_33093_69	263820.PTO1507	1.021e-07	57.0	COG1030@1|root,arCOG01910@2157|Archaea	2157|Archaea	O	Membrane-bound serine protease (ClpP class)	-	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	NfeD
MMS3_k127_33093_48	273075.Ta1078	1.569e-40	163.0	COG0436@1|root,arCOG04334@2157|Archaea,2Y7JJ@28890|Euryarchaeota,242DD@183967|Thermoplasmata	183967|Thermoplasmata	E	Aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
MMS3_k127_33093_23	760142.Hipma_0406	1.54e-88	304.0	COG0863@1|root,COG0863@2|Bacteria,1PCSY@1224|Proteobacteria,43A4T@68525|delta/epsilon subdivisions,2WYRP@28221|Deltaproteobacteria,2M7NX@213113|Desulfurellales	28221|Deltaproteobacteria	L	DNA methylase	-	-	-	-	-	-	-	-	-	-	-	-	N6_N4_Mtase
MMS3_k127_33093_65	273116.14324599	4.773e-15	83.0	arCOG07404@1|root,arCOG07404@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_33093_52	1294265.JCM21738_1205	5.107e-28	116.0	COG0640@1|root,COG0640@2|Bacteria,1VA4S@1239|Firmicutes,4HKBK@91061|Bacilli,1ZHGM@1386|Bacillus	91061|Bacilli	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
MMS3_k127_33093_42	1111479.AXAR01000002_gene1898	1.227e-47	174.0	COG3832@1|root,COG3832@2|Bacteria,1V4V8@1239|Firmicutes,4HH3Z@91061|Bacilli,27A2Y@186823|Alicyclobacillaceae	91061|Bacilli	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
MMS3_k127_33093_75	543526.Htur_2776	3.299e-05	53.0	arCOG04567@1|root,arCOG04567@2157|Archaea,2XWK3@28890|Euryarchaeota,23VF6@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_33093_61	290399.Arth_1860	1.596e-24	115.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	afr	-	1.1.1.292	ko:K19181	-	-	-	-	ko00000,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
MMS3_k127_33093_7	273116.14324338	1.751e-194	618.0	COG0477@1|root,arCOG02682@2157|Archaea,2XWP6@28890|Euryarchaeota,24240@183967|Thermoplasmata	183967|Thermoplasmata	G	Sugar (and other) transporter	-	-	-	ko:K08176	-	-	-	-	ko00000,ko02000	2.A.1.9	-	-	Sugar_tr
MMS3_k127_33093_12	273075.Ta0113	4.704e-138	451.0	COG1171@1|root,arCOG01431@2157|Archaea,2XT4W@28890|Euryarchaeota,2420P@183967|Thermoplasmata	183967|Thermoplasmata	E	Pyridoxal-phosphate dependent enzyme	-	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT_4,PALP
MMS3_k127_33093_63	273116.14324234	4.369e-20	92.0	COG1254@1|root,arCOG01674@2157|Archaea,2Y7C5@28890|Euryarchaeota,242G3@183967|Thermoplasmata	183967|Thermoplasmata	C	acylphosphatase activity	acyP	-	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	-	R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000	-	-	-	Acylphosphatase
MMS3_k127_33093_5	263820.PTO0744	1.026e-197	622.0	COG1812@1|root,arCOG01678@2157|Archaea,2XT7J@28890|Euryarchaeota,241JZ@183967|Thermoplasmata	183967|Thermoplasmata	H	Catalyzes the formation of S-adenosylmethionine from methionine and ATP	mat	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	AdoMet_Synthase
MMS3_k127_33093_11	273116.14324230	5.555e-144	472.0	COG0138@1|root,arCOG02824@2157|Archaea,2XT5P@28890|Euryarchaeota,241IY@183967|Thermoplasmata	183967|Thermoplasmata	F	AICARFT/IMPCHase bienzyme	-	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
MMS3_k127_33093_32	273116.14324232	1.207e-70	250.0	COG3389@1|root,arCOG04463@2157|Archaea,2XSZT@28890|Euryarchaeota,2427H@183967|Thermoplasmata	183967|Thermoplasmata	S	Presenilin, signal peptide peptidase, family	-	-	-	-	-	-	-	-	-	-	-	-	SPP
MMS3_k127_33093_2	273116.14324233	5.727e-279	876.0	COG0550@1|root,arCOG01527@2157|Archaea,2XU6T@28890|Euryarchaeota,241KQ@183967|Thermoplasmata	183967|Thermoplasmata	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,zf-C4_Topoisom
MMS3_k127_33093_17	1006006.Mcup_2000	1.435e-113	380.0	COG1055@1|root,arCOG00238@2157|Archaea	2157|Archaea	P	Citrate transporter	-	-	-	ko:K03893	-	-	-	-	ko00000,ko02000	2.A.45.1,3.A.4.1	-	-	ArsB
MMS3_k127_33093_26	273116.14325124	7.268e-79	284.0	COG2244@1|root,arCOG02209@2157|Archaea,2Y7AT@28890|Euryarchaeota,24273@183967|Thermoplasmata	183967|Thermoplasmata	S	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt_3,Polysacc_synt_C
MMS3_k127_33093_43	273075.Ta0336	5.651e-45	166.0	arCOG03678@1|root,arCOG03677@2157|Archaea,2Y0K5@28890|Euryarchaeota,242AH@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_33093_18	273116.14324650	1.028e-112	371.0	COG1208@1|root,arCOG00663@2157|Archaea,2XUID@28890|Euryarchaeota,24252@183967|Thermoplasmata	183967|Thermoplasmata	M	Nucleotidyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transferase
MMS3_k127_33093_68	933801.Ahos_1732	4.216e-09	69.0	COG1277@1|root,arCOG02441@2157|Archaea,2XQE4@28889|Crenarchaeota	28889|Crenarchaeota	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
MMS3_k127_33093_30	930945.SiRe_0588	3.405e-73	257.0	COG1131@1|root,arCOG00194@2157|Archaea,2XPNB@28889|Crenarchaeota	28889|Crenarchaeota	V	PFAM ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
MMS3_k127_33093_3	273075.Ta0291	2.42e-234	743.0	COG1250@1|root,arCOG00249@2157|Archaea,2XT6B@28890|Euryarchaeota,24225@183967|Thermoplasmata	183967|Thermoplasmata	I	Enoyl-CoA hydratase/isomerase	-	-	1.1.1.35,4.2.1.17	ko:K15016	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00374,M00375	R01975,R03026	RC00117,RC00831	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
MMS3_k127_33093_67	1121472.AQWN01000009_gene291	1.089e-10	66.0	COG3255@1|root,COG3255@2|Bacteria,1VFEY@1239|Firmicutes,24QXQ@186801|Clostridia,263BY@186807|Peptococcaceae	186801|Clostridia	I	sterol carrier protein	-	-	-	-	-	-	-	-	-	-	-	-	SCP2
MMS3_k127_33093_20	273075.Ta0125	6.12e-96	318.0	COG0526@1|root,arCOG01218@2157|Archaea,2XY63@28890|Euryarchaeota,2423H@183967|Thermoplasmata	183967|Thermoplasmata	O	Glutaredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_3
MMS3_k127_33093_29	273075.Ta0124m	2.635e-73	254.0	COG0013@1|root,arCOG01254@2157|Archaea,2XTZC@28890|Euryarchaeota,241V1@183967|Thermoplasmata	183967|Thermoplasmata	J	Threonyl and Alanyl tRNA synthetase second additional domain	-	-	-	ko:K07050	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA-synt_2c,tRNA_SAD
MMS3_k127_33093_50	1050201.KB913034_gene908	3.02e-36	145.0	COG0491@1|root,COG0491@2|Bacteria,1V6FA@1239|Firmicutes,3VQY8@526524|Erysipelotrichia	526524|Erysipelotrichia	S	Metallo-beta-lactamase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
MMS3_k127_33093_47	263820.PTO0235	1.354e-40	156.0	COG2890@1|root,arCOG00109@2157|Archaea,2XWJZ@28890|Euryarchaeota,241U1@183967|Thermoplasmata	183967|Thermoplasmata	Q	Methyltransferase domain	-	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS
MMS3_k127_33093_13	273075.Ta1489	8.801e-134	436.0	COG1163@1|root,arCOG00358@2157|Archaea,2XTYK@28890|Euryarchaeota,241J7@183967|Thermoplasmata	183967|Thermoplasmata	S	C-terminal region of MMR_HSR1 domain	-	-	-	ko:K06944	-	-	-	-	ko00000	-	-	-	MMR_HSR1,MMR_HSR1_Xtn,TGS
MMS3_k127_33093_37	273116.14324228	2.407e-49	180.0	COG0456@1|root,arCOG00833@2157|Archaea,2Y0G0@28890|Euryarchaeota,241VK@183967|Thermoplasmata	183967|Thermoplasmata	K	Acetyltransferase (GNAT) domain	-	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
MMS3_k127_33093_6	273075.Ta0057m	6.899e-195	625.0	COG1199@1|root,arCOG00770@2157|Archaea,2XTH2@28890|Euryarchaeota,241VX@183967|Thermoplasmata	183967|Thermoplasmata	L	HELICc2	-	-	3.6.4.12	ko:K10844	ko03022,ko03420,map03022,map03420	M00290	-	-	ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	DEAD_2,HBB,Helicase_C_2
MMS3_k127_33093_45	263820.PTO0619	1.641e-41	159.0	COG2150@1|root,arCOG02317@2157|Archaea,2XYHC@28890|Euryarchaeota,242BH@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	ko:K07103	-	-	-	-	ko00000	-	-	-	-
MMS3_k127_33093_27	263820.PTO0557	3.522e-78	272.0	COG1395@1|root,arCOG04152@2157|Archaea,2XTMG@28890|Euryarchaeota,241RI@183967|Thermoplasmata	183967|Thermoplasmata	K	DNA-binding transcription factor activity	-	-	-	ko:K07728	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3
MMS3_k127_33093_36	273116.14324508	2.286e-50	187.0	arCOG07412@1|root,arCOG07412@2157|Archaea,2Y0S5@28890|Euryarchaeota,241XA@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_33093_39	263820.PTO0625	1.118e-48	180.0	COG0293@1|root,arCOG00079@2157|Archaea,2XT12@28890|Euryarchaeota,241TF@183967|Thermoplasmata	183967|Thermoplasmata	J	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit	rlmE	-	2.1.1.166	ko:K02427	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ
MMS3_k127_33093_38	263820.PTO0624	4.113e-49	177.0	COG0509@1|root,arCOG01303@2157|Archaea,2XY1B@28890|Euryarchaeota,242A6@183967|Thermoplasmata	183967|Thermoplasmata	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
MMS3_k127_33093_76	1096546.WYO_4312	7.543e-05	51.0	COG1514@1|root,COG1514@2|Bacteria,1RDB2@1224|Proteobacteria,2U7FV@28211|Alphaproteobacteria,1JUVF@119045|Methylobacteriaceae	28211|Alphaproteobacteria	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	ligT	-	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
MMS3_k127_33093_55	273116.14324255	1.583e-26	111.0	arCOG05352@1|root,arCOG05352@2157|Archaea,2Y4MS@28890|Euryarchaeota,242C9@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_33093_35	273075.Ta0115	8.535e-61	213.0	COG0640@1|root,arCOG05349@2157|Archaea,2XYUG@28890|Euryarchaeota,241TE@183967|Thermoplasmata	183967|Thermoplasmata	K	DNA-binding transcription factor activity	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_33093_64	263820.PTO0596	2.042e-19	96.0	COG0169@1|root,arCOG02097@2157|Archaea,2Y5JG@28890|Euryarchaeota,242HC@183967|Thermoplasmata	183967|Thermoplasmata	E	Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate	aroD	-	4.2.1.10	ko:K03785	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_I
MMS3_k127_33093_33	263820.PTO0597	4.767e-69	240.0	COG2095@1|root,arCOG01997@2157|Archaea,2XZEI@28890|Euryarchaeota,2426E@183967|Thermoplasmata	183967|Thermoplasmata	U	MarC family integral membrane protein	-	-	-	ko:K05595	-	-	-	-	ko00000,ko02000	2.A.95.1	-	-	MarC
MMS3_k127_33093_53	273526.SMDB11_3949	1.859e-27	117.0	COG0537@1|root,COG0537@2|Bacteria,1R7GK@1224|Proteobacteria,1S0R0@1236|Gammaproteobacteria,402YV@613|Serratia	1236|Gammaproteobacteria	FG	HIT domain	hit	-	-	-	-	-	-	-	-	-	-	-	HIT
MMS3_k127_33093_1	273075.Ta0421	1.319e-302	938.0	COG0365@1|root,arCOG04201@2157|Archaea,2Y84I@28890|Euryarchaeota,2424Z@183967|Thermoplasmata	183967|Thermoplasmata	I	Acetyl-coenzyme A synthetase N-terminus	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
MMS3_k127_3578887_33	269797.Mbar_A0608	1.188e-29	132.0	COG0535@1|root,arCOG00938@2157|Archaea,2XZ9M@28890|Euryarchaeota,2NANF@224756|Methanomicrobia	224756|Methanomicrobia	S	Radical SAM superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DUF3463,Radical_SAM
MMS3_k127_3578887_27	235909.GK1714	2.703e-45	171.0	COG2808@1|root,COG2808@2|Bacteria,1UYCC@1239|Firmicutes,4HDZ7@91061|Bacilli,1WHVS@129337|Geobacillus	91061|Bacilli	K	Putative FMN-binding domain	-	-	-	ko:K07734	-	-	-	-	ko00000,ko03000	-	-	-	FMN_bind_2
MMS3_k127_3578887_15	263820.PTO1483	9.344e-101	344.0	COG0531@1|root,arCOG00009@2157|Archaea,2XTX6@28890|Euryarchaeota	28890|Euryarchaeota	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2,AA_permease_C
MMS3_k127_3578887_23	768679.TTX_0809	1.841e-58	216.0	COG1748@1|root,arCOG00243@2157|Archaea,2XQJJ@28889|Crenarchaeota	28889|Crenarchaeota	C	Saccharopine dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP,Semialdhyde_dh,UDPG_MGDP_dh_N
MMS3_k127_3578887_32	933801.Ahos_0430	6.644e-31	128.0	COG1522@1|root,arCOG01580@2157|Archaea,2XQS8@28889|Crenarchaeota	28889|Crenarchaeota	K	ASNC family	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_24
MMS3_k127_3578887_11	273063.STK_11200	3.095e-136	441.0	COG0167@1|root,arCOG00603@2157|Archaea,2XQ06@28889|Crenarchaeota	28889|Crenarchaeota	C	TIGRFAM dihydroorotate dehydrogenase family protein	-	-	1.3.1.1	ko:K17723	ko00240,ko00410,ko00770,ko01100,map00240,map00410,map00770,map01100	M00046	R00977,R01414,R11026	RC00072,RC00123	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh,Fer4,Fer4_21
MMS3_k127_3578887_13	273063.STK_11210	1.189e-119	390.0	COG0388@1|root,arCOG00062@2157|Archaea,2XPK5@28889|Crenarchaeota	2157|Archaea	S	PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	3.5.1.6,3.5.3.12	ko:K01431,ko:K10536	ko00240,ko00330,ko00410,ko00770,ko00983,ko01100,map00240,map00330,map00410,map00770,map00983,map01100	M00046	R00905,R01416,R04666,R08228	RC00096,RC00177	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,PAD_porph
MMS3_k127_3578887_21	1006006.Mcup_0700	2.06e-69	250.0	COG0477@1|root,arCOG00135@2157|Archaea	2157|Archaea	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS3_k127_3578887_35	273116.14325673	1.764e-19	97.0	COG0640@1|root,arCOG01687@2157|Archaea	2157|Archaea	K	transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
MMS3_k127_3578887_2	273063.STK_11180	2.499e-200	633.0	COG0044@1|root,arCOG00689@2157|Archaea,2XQ3G@28889|Crenarchaeota	28889|Crenarchaeota	F	PFAM amidohydrolase	-	-	3.5.2.2,3.5.2.5	ko:K01464,ko:K01466	ko00230,ko00240,ko00410,ko00770,ko00983,ko01100,ko01120,map00230,map00240,map00410,map00770,map00983,map01100,map01120	M00046,M00546	R02269,R02425,R03055,R08227	RC00632,RC00680	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Amidohydro_1
MMS3_k127_3578887_8	572478.Vdis_0752	2.308e-165	537.0	COG1953@1|root,arCOG03448@2157|Archaea,2XPQH@28889|Crenarchaeota	28889|Crenarchaeota	F	Permease for cytosine/purines, uracil, thiamine, allantoin	-	-	-	ko:K03457	-	-	-	-	ko00000	2.A.39	-	-	Transp_cyt_pur
MMS3_k127_3578887_6	1056495.Calag_0186	9.059e-190	608.0	COG1012@1|root,arCOG01252@2157|Archaea,2XRV5@28889|Crenarchaeota	28889|Crenarchaeota	C	Aldehyde dehydrogenase family	-	-	1.2.1.18,1.2.1.27	ko:K00140	ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200	M00013	R00705,R00706,R00922,R00935	RC00004,RC02723,RC02817	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
MMS3_k127_3578887_4	1056495.Calag_0187	1.188e-193	613.0	COG0160@1|root,arCOG00916@2157|Archaea,2XPMV@28889|Crenarchaeota	28889|Crenarchaeota	E	Aminotransferase class-III	-	-	2.6.1.55	ko:K15372	ko00410,ko00430,ko01100,map00410,map00430,map01100	-	R00908,R01684	RC00006,RC00062	ko00000,ko00001,ko01000	-	-	-	Aminotran_3
MMS3_k127_3578887_22	273057.SSO2071	1.416e-61	216.0	COG1225@1|root,arCOG00310@2157|Archaea,2XRWS@28889|Crenarchaeota	28889|Crenarchaeota	O	AhpC/TSA family	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
MMS3_k127_3578887_16	263820.PTO0172	1.23e-92	313.0	COG2421@1|root,arCOG01004@2157|Archaea,2XU60@28890|Euryarchaeota	28890|Euryarchaeota	C	acetamidase formamidase	-	-	-	-	-	-	-	-	-	-	-	-	FmdA_AmdA
MMS3_k127_3578887_10	273075.Ta1380	5.012e-139	453.0	COG1602@1|root,arCOG04269@2157|Archaea,2XTEQ@28890|Euryarchaeota,2423F@183967|Thermoplasmata	183967|Thermoplasmata	S	Archaeal Nre, N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Nre_C,Nre_N
MMS3_k127_3578887_20	263820.PTO1500	7.152e-73	255.0	COG1533@1|root,arCOG01290@2157|Archaea,2XY2A@28890|Euryarchaeota,241RK@183967|Thermoplasmata	183967|Thermoplasmata	L	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
MMS3_k127_3578887_24	273075.Ta0668	2.165e-58	214.0	COG0491@1|root,arCOG00498@2157|Archaea,2XTW0@28890|Euryarchaeota,241WV@183967|Thermoplasmata	183967|Thermoplasmata	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
MMS3_k127_3578887_1	263820.PTO1415	1.231e-272	860.0	COG0188@1|root,arCOG04367@2157|Archaea,2XTZV@28890|Euryarchaeota,241JQ@183967|Thermoplasmata	183967|Thermoplasmata	L	DNA Topoisomerase IV	-	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
MMS3_k127_3578887_0	273075.Ta1055	7.345e-280	872.0	COG0187@1|root,arCOG04371@2157|Archaea,2XSVX@28890|Euryarchaeota,241Z0@183967|Thermoplasmata	183967|Thermoplasmata	L	TopoisomeraseII	-	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
MMS3_k127_3578887_34	273075.Ta1056	3.685e-25	106.0	arCOG04007@1|root,arCOG04007@2157|Archaea,2Y580@28890|Euryarchaeota,242FA@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_3578887_38	273116.14324982	3.321e-10	64.0	COG5466@1|root,arCOG05278@2157|Archaea	2157|Archaea	S	small metal-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF1059
MMS3_k127_3578887_17	263820.PTO0879	1.427e-90	308.0	COG1084@1|root,arCOG00352@2157|Archaea,2XU5R@28890|Euryarchaeota,241NE@183967|Thermoplasmata	183967|Thermoplasmata	S	Nucleolar GTP-binding protein 1 (NOG1)	-	-	-	ko:K06943	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	MMR_HSR1,NOG1
MMS3_k127_3578887_3	273116.14325348	4.592e-200	637.0	COG0008@1|root,arCOG04302@2157|Archaea,2XSYV@28890|Euryarchaeota,241JP@183967|Thermoplasmata	183967|Thermoplasmata	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
MMS3_k127_3578887_37	273075.Ta0943	1.73e-16	81.0	COG1873@1|root,arCOG02155@2157|Archaea	2157|Archaea	S	PRC-barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PRC
MMS3_k127_3578887_19	273075.Ta0944m	5.847e-75	256.0	COG0518@1|root,arCOG00087@2157|Archaea,2XT3G@28890|Euryarchaeota,241QC@183967|Thermoplasmata	183967|Thermoplasmata	F	Catalyzes the synthesis of GMP from XMP	guaAA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase
MMS3_k127_3578887_7	273116.14325351	2.257e-172	543.0	COG1405@1|root,arCOG01981@2157|Archaea,2XU76@28890|Euryarchaeota,2422B@183967|Thermoplasmata	183967|Thermoplasmata	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	tfbB	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
MMS3_k127_3578887_12	263820.PTO0772	6.622e-132	431.0	COG1473@1|root,arCOG01108@2157|Archaea,2XV81@28890|Euryarchaeota,241Y2@183967|Thermoplasmata	183967|Thermoplasmata	E	Peptidase family M20/M25/M40	-	-	-	ko:K01436	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
MMS3_k127_3578887_28	273116.14324396	7.588e-41	157.0	COG1670@1|root,arCOG00842@2157|Archaea,2Y7BJ@28890|Euryarchaeota,242C2@183967|Thermoplasmata	183967|Thermoplasmata	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
MMS3_k127_3578887_30	273075.Ta1415	9.731e-38	146.0	COG2210@1|root,arCOG02064@2157|Archaea,2XYJZ@28890|Euryarchaeota	28890|Euryarchaeota	S	DsrE/DsrF/DrsH-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE_2
MMS3_k127_3578887_31	273075.Ta1414	1.541e-33	130.0	COG0425@1|root,arCOG02062@2157|Archaea,2XZUG@28890|Euryarchaeota	28890|Euryarchaeota	O	redox protein, regulator of disulfide bond formation	-	-	-	-	-	-	-	-	-	-	-	-	TusA
MMS3_k127_3578887_5	273116.14325643	2.184e-192	616.0	COG1032@1|root,arCOG01364@2157|Archaea,2XVND@28890|Euryarchaeota,2423G@183967|Thermoplasmata	183967|Thermoplasmata	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
MMS3_k127_3578887_9	273116.14325698	1.184e-147	476.0	COG0446@1|root,arCOG01064@2157|Archaea,2XUFE@28890|Euryarchaeota,24203@183967|Thermoplasmata	183967|Thermoplasmata	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
MMS3_k127_3578887_39	1307436.PBF_11452	0.0009972	48.0	COG2427@1|root,COG2427@2|Bacteria,1VDZ4@1239|Firmicutes,4HP7W@91061|Bacilli,1ZDHJ@1386|Bacillus	91061|Bacilli	S	Protein of unknown function (DUF1641)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1641
MMS3_k127_3578887_14	525904.Tter_1226	4.85e-107	355.0	COG0492@1|root,COG0492@2|Bacteria,2NNS7@2323|unclassified Bacteria	2|Bacteria	O	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	trxB	GO:0000166,GO:0001666,GO:0003674,GO:0003824,GO:0004791,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0008152,GO:0009628,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019725,GO:0036094,GO:0036293,GO:0040007,GO:0042221,GO:0042592,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070402,GO:0070482,GO:0070887,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748	1.8.1.9	ko:K00384,ko:K03671	ko00450,ko04621,ko05418,map00450,map04621,map05418	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000,ko03110	-	-	iNJ661.Rv3913	Pyr_redox_2
MMS3_k127_3578887_26	1042877.GQS_01435	1.47e-48	179.0	COG1670@1|root,arCOG00842@2157|Archaea,2XVC6@28890|Euryarchaeota,243ZK@183968|Thermococci	183968|Thermococci	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
MMS3_k127_3578887_36	273075.Ta1110	1.065e-18	90.0	COG0640@1|root,arCOG01681@2157|Archaea	2157|Archaea	K	regulatory protein, arsR	-	-	-	ko:K21903	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
MMS3_k127_3578887_25	1379698.RBG1_1C00001G0821	1.288e-48	188.0	COG0798@1|root,COG0798@2|Bacteria,2NNWJ@2323|unclassified Bacteria	2|Bacteria	P	Sodium Bile acid symporter family	arsB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015104,GO:0015105,GO:0015291,GO:0015297,GO:0015318,GO:0015698,GO:0015699,GO:0015700,GO:0016020,GO:0022804,GO:0022857,GO:0034220,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656	1.20.4.1	ko:K03325,ko:K03741	-	-	-	-	ko00000,ko01000,ko02000	2.A.59	-	iYO844.BSU25790	SBF
MMS3_k127_3578887_18	1056495.Calag_1003	4.839e-76	286.0	COG3391@1|root,arCOG06052@1|root,arCOG02560@2157|Archaea,arCOG06052@2157|Archaea,2XRYP@28889|Crenarchaeota	28889|Crenarchaeota	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_3578887_29	405948.SACE_4410	4.483e-38	147.0	COG0346@1|root,COG0346@2|Bacteria,2IKNC@201174|Actinobacteria,4E563@85010|Pseudonocardiales	201174|Actinobacteria	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
MMS3_k127_3810158_28	273075.Ta0892	6.628e-74	263.0	COG4198@1|root,arCOG03573@2157|Archaea,2XZJQ@28890|Euryarchaeota,241UW@183967|Thermoplasmata	183967|Thermoplasmata	S	Protein of unknown function (DUF1015)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1015
MMS3_k127_3810158_27	324602.Caur_1056	5.01e-76	264.0	COG0648@1|root,COG0648@2|Bacteria,2G5XZ@200795|Chloroflexi,374VN@32061|Chloroflexia	32061|Chloroflexia	L	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin	nfo	GO:0003674,GO:0003824,GO:0003906,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008081,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
MMS3_k127_3810158_18	263820.PTO1067	7.912e-107	350.0	COG1378@1|root,arCOG02037@2157|Archaea,2XX7F@28890|Euryarchaeota,24255@183967|Thermoplasmata	183967|Thermoplasmata	K	Sugar-specific transcriptional regulator TrmB	-	-	-	-	-	-	-	-	-	-	-	-	Regulator_TrmB,TrmB
MMS3_k127_3810158_30	876269.ARWA01000001_gene2010	2.649e-70	244.0	COG4122@1|root,COG4122@2|Bacteria,1R4VI@1224|Proteobacteria,2U6AD@28211|Alphaproteobacteria,3NAPF@45404|Beijerinckiaceae	28211|Alphaproteobacteria	S	O-methyltransferase	mdmC	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_3
MMS3_k127_3810158_47	273075.Ta1231	2.004e-28	122.0	COG3413@1|root,arCOG02271@2157|Archaea,2Y7BN@28890|Euryarchaeota,242D2@183967|Thermoplasmata	183967|Thermoplasmata	K	HTH DNA binding domain	-	-	-	ko:K06930	-	-	-	-	ko00000	-	-	-	HTH_10
MMS3_k127_3810158_0	263820.PTO1241	2.706e-320	996.0	COG0209@1|root,arCOG03713@1|root,arCOG03713@2157|Archaea,arCOG04276@2157|Archaea,2XUBW@28890|Euryarchaeota,241MT@183967|Thermoplasmata	183967|Thermoplasmata	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN
MMS3_k127_3810158_11	273116.14324469	1.534e-125	411.0	COG0750@1|root,arCOG00609@2157|Archaea,2XT29@28890|Euryarchaeota,241Y5@183967|Thermoplasmata	183967|Thermoplasmata	M	Peptidase family M50	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_3810158_32	273116.14324445	5.58e-65	236.0	COG1630@1|root,arCOG00367@2157|Archaea,2Y3KS@28890|Euryarchaeota,2427K@183967|Thermoplasmata	183967|Thermoplasmata	L	NurA	-	-	-	-	-	-	-	-	-	-	-	-	NurA
MMS3_k127_3810158_6	273075.Ta0159	8.411e-161	522.0	COG0433@1|root,arCOG00280@2157|Archaea,2XT33@28890|Euryarchaeota,241YU@183967|Thermoplasmata	183967|Thermoplasmata	L	Type IV secretory system Conjugative DNA transfer	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF87,HAS-barrel
MMS3_k127_3810158_20	273075.Ta0158	4.058e-94	321.0	COG0420@1|root,arCOG00397@2157|Archaea,2XT7A@28890|Euryarchaeota,241W3@183967|Thermoplasmata	183967|Thermoplasmata	L	Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single- stranded endonuclease activity	mre11	-	-	ko:K03547	-	-	-	-	ko00000,ko03400	-	-	-	Metallophos
MMS3_k127_3810158_22	273075.Ta0157	1.915e-89	327.0	COG0419@1|root,arCOG00368@2157|Archaea,2XTC7@28890|Euryarchaeota,241ZK@183967|Thermoplasmata	183967|Thermoplasmata	L	Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50 Mre11 complex	rad50	-	-	ko:K03546	-	-	-	-	ko00000,ko03400	-	-	-	Rad50_zn_hook,SMC_N
MMS3_k127_3810158_19	273075.Ta0153	9.24e-97	321.0	COG0463@1|root,arCOG00895@2157|Archaea,2Y7QN@28890|Euryarchaeota,2424V@183967|Thermoplasmata	183967|Thermoplasmata	M	Glycosyltransferase like family 2	-	-	-	ko:K00786	-	-	-	-	ko00000,ko01000	-	-	-	Glycos_transf_2
MMS3_k127_3810158_50	673860.AciM339_0306	6.36e-24	108.0	COG2450@1|root,arCOG02263@2157|Archaea,2XXYF@28890|Euryarchaeota,3F3BW@33867|unclassified Euryarchaeota	28890|Euryarchaeota	D	Pfam:DUF552	sepF	-	-	ko:K09152	-	-	-	-	ko00000	-	-	-	SepF
MMS3_k127_3810158_17	273116.14324441	8.506e-110	369.0	COG0477@1|root,arCOG00130@2157|Archaea,2Y8EG@28890|Euryarchaeota,2424M@183967|Thermoplasmata	183967|Thermoplasmata	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS3_k127_3810158_56	273116.14325504	6.295e-18	84.0	COG5466@1|root,arCOG05278@2157|Archaea,2Y5U3@28890|Euryarchaeota,242H8@183967|Thermoplasmata	183967|Thermoplasmata	S	Protein of unknown function (DUF1059)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1059
MMS3_k127_3810158_45	315750.BPUM_3683	4.117e-38	147.0	COG0454@1|root,COG0456@2|Bacteria,1VAU8@1239|Firmicutes,4HMA6@91061|Bacilli,1ZFP4@1386|Bacillus	91061|Bacilli	K	Acetyltransferase	yycN	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
MMS3_k127_3810158_46	403833.Pmob_1031	1.808e-32	134.0	COG3404@1|root,COG3404@2|Bacteria,2GD2A@200918|Thermotogae	200918|Thermotogae	E	PFAM Formiminotransferase-cyclodeaminase	-	-	-	-	-	-	-	-	-	-	-	-	FTCD_C
MMS3_k127_3810158_12	273116.14324304	1.064e-123	402.0	COG3404@1|root,arCOG05394@2157|Archaea,2XX41@28890|Euryarchaeota,2420F@183967|Thermoplasmata	183967|Thermoplasmata	E	Catalyzes the transfer of the formyl group from N- formylglutamate to tetrahydrofolate (THF) to yield 5- formyltetrahydrofolate (5-CHO-THF) and glutamate (Glu). The triglutamate form of 5-CHO-THF (5-CHO-THF-Glu3) can also be used as substrate. It can also catalyzes the transfer of the formimino group from N-formiminoglutamate to tetrahydrofolate (THF) to yield 5-formiminotetrahydrofolate (5-NH CH-THF) and glutamate (Glu). It can replace YgfA to catalyzes the irreversible ATP-dependent transformation of 5-CHO-THF to form 5,10-methenyltetrahydrofolate (5,10-CH THF)	-	-	2.1.2.5	ko:K00603	ko00340,ko00670,ko01100,map00340,map00670,map01100	-	R02287,R03189	RC00165,RC00221,RC00223,RC00870	ko00000,ko00001,ko01000	-	-	-	FTCD,FTCD_N
MMS3_k127_3810158_41	1048834.TC41_1494	3.875e-44	173.0	COG0208@1|root,COG0208@2|Bacteria,1TQTH@1239|Firmicutes,4H9WX@91061|Bacilli	91061|Bacilli	F	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides	nrdB	-	1.17.4.1	ko:K00526	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_sm
MMS3_k127_3810158_1	1501230.ET33_14890	2.947e-261	825.0	COG0209@1|root,COG0209@2|Bacteria,1TPFH@1239|Firmicutes,4H9X0@91061|Bacilli,26U46@186822|Paenibacillaceae	91061|Bacilli	F	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides	nrdA	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN
MMS3_k127_3810158_13	1120972.AUMH01000002_gene2669	1.359e-120	396.0	COG0208@1|root,COG0208@2|Bacteria,1TQTH@1239|Firmicutes,4H9WX@91061|Bacilli	91061|Bacilli	F	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides	nrdB	-	1.17.4.1	ko:K00526	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_sm
MMS3_k127_3810158_55	633148.Tagg_1063	2.16e-19	91.0	COG1324@1|root,arCOG04231@2157|Archaea,2XQQS@28889|Crenarchaeota	28889|Crenarchaeota	P	PFAM CutA1 divalent ion tolerance protein	-	-	-	ko:K03926	-	-	-	-	ko00000	-	-	-	CutA1
MMS3_k127_3810158_43	666510.ASAC_0625	1.895e-41	161.0	COG4280@1|root,arCOG06010@2157|Archaea,2XQZ4@28889|Crenarchaeota	28889|Crenarchaeota	S	Ferrous iron uptake permease, iron-lead transporter	-	-	-	-	-	-	-	-	-	-	-	-	OFeT_1
MMS3_k127_3810158_37	32057.KB217478_gene2758	4.057e-49	180.0	COG0783@1|root,COG0783@2|Bacteria,1G54E@1117|Cyanobacteria,1HMZ3@1161|Nostocales	1117|Cyanobacteria	P	Belongs to the Dps family	dps	-	-	ko:K04047	-	-	-	-	ko00000,ko03036	-	-	-	Ferritin
MMS3_k127_3810158_52	273075.Ta0337	1.98e-22	100.0	arCOG03681@1|root,arCOG03681@2157|Archaea,2Y5YK@28890|Euryarchaeota,242HF@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_3810158_31	572478.Vdis_1929	4.269e-65	243.0	COG4986@1|root,arCOG00174@2157|Archaea,2XPPU@28889|Crenarchaeota	28889|Crenarchaeota	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
MMS3_k127_3810158_60	263820.PTO0330	3.413e-12	70.0	COG2383@1|root,arCOG04811@2157|Archaea,2Y5ZI@28890|Euryarchaeota,242G1@183967|Thermoplasmata	183967|Thermoplasmata	S	FUN14 family	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_3810158_38	273075.Ta0294	3.191e-48	186.0	COG1960@1|root,arCOG01707@2157|Archaea,2Y3XS@28890|Euryarchaeota,242BF@183967|Thermoplasmata	183967|Thermoplasmata	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_N
MMS3_k127_3810158_9	273075.Ta0295m	3.889e-140	454.0	COG1960@1|root,arCOG01708@2157|Archaea,2Y7GC@28890|Euryarchaeota,24217@183967|Thermoplasmata	183967|Thermoplasmata	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
MMS3_k127_3810158_4	273116.14325566	9.164e-181	572.0	COG0183@1|root,arCOG01282@2157|Archaea,2XT8C@28890|Euryarchaeota,2423Q@183967|Thermoplasmata	183967|Thermoplasmata	I	Beta-ketoacyl synthase, N-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
MMS3_k127_3810158_42	273116.14325133	1.196e-42	166.0	arCOG03534@1|root,arCOG03534@2157|Archaea	2157|Archaea	S	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
MMS3_k127_3810158_8	945713.IALB_1465	1.525e-148	493.0	COG0247@1|root,COG0247@2|Bacteria	2|Bacteria	C	lactate metabolic process	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
MMS3_k127_3810158_25	273116.14325648	7.068e-78	267.0	COG2086@1|root,arCOG00446@2157|Archaea,2XZ39@28890|Euryarchaeota,24263@183967|Thermoplasmata	183967|Thermoplasmata	C	Electron transfer flavoprotein domain	-	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
MMS3_k127_3810158_21	273075.Ta0212	8.619e-93	313.0	COG2025@1|root,arCOG00447@2157|Archaea,2XT06@28890|Euryarchaeota,24204@183967|Thermoplasmata	183967|Thermoplasmata	C	Electron transfer flavoprotein FAD-binding domain	-	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
MMS3_k127_3810158_2	273116.14325561	1.493e-203	660.0	COG0308@1|root,arCOG02969@2157|Archaea,2XVY4@28890|Euryarchaeota,24243@183967|Thermoplasmata	183967|Thermoplasmata	E	Proteases F1, F2 and F3 degrade oligopeptides produced by Tricorn (themselves probably produced by the proteasome), yielding free amino acids	trf2	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K13722	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	ERAP1_C,Peptidase_M1
MMS3_k127_3810158_14	263820.PTO0550	6.554e-119	388.0	COG0320@1|root,arCOG00660@2157|Archaea,2XUQB@28890|Euryarchaeota	28890|Euryarchaeota	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	-	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
MMS3_k127_3810158_10	273116.14324315	4.32e-132	428.0	COG1071@1|root,arCOG01054@2157|Archaea,2XUGH@28890|Euryarchaeota,24218@183967|Thermoplasmata	183967|Thermoplasmata	C	Dehydrogenase E1 component	-	-	1.2.4.1	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
MMS3_k127_3810158_7	273116.14324314	2.672e-152	486.0	COG0022@1|root,arCOG01052@2157|Archaea,2XT3K@28890|Euryarchaeota,2420C@183967|Thermoplasmata	183967|Thermoplasmata	C	Transketolase, pyrimidine binding domain	-	-	1.2.4.1	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
MMS3_k127_3810158_15	273116.14324313	7.195e-115	382.0	COG0508@1|root,arCOG01706@2157|Archaea,2XTSS@28890|Euryarchaeota,2421N@183967|Thermoplasmata	183967|Thermoplasmata	C	Biotin-lipoyl like	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
MMS3_k127_3810158_5	273075.Ta1435	1.07e-170	546.0	COG1249@1|root,arCOG01068@2157|Archaea,2XTXN@28890|Euryarchaeota,2423A@183967|Thermoplasmata	183967|Thermoplasmata	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
MMS3_k127_3810158_48	404380.Gbem_0707	1.809e-27	120.0	COG0321@1|root,COG0321@2|Bacteria,1MU6A@1224|Proteobacteria,42RIC@68525|delta/epsilon subdivisions	1224|Proteobacteria	H	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate	lipB	GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564	2.3.1.181	ko:K03801	ko00785,ko01100,map00785,map01100	-	R07766,R07769	RC00039,RC00992,RC02867	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
MMS3_k127_3810158_36	263820.PTO0544	1.403e-53	194.0	COG2096@1|root,arCOG00489@2157|Archaea,2XTKK@28890|Euryarchaeota,2425V@183967|Thermoplasmata	183967|Thermoplasmata	H	Cobalamin adenosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Cob_adeno_trans
MMS3_k127_3810158_39	263820.PTO1148	1.854e-44	168.0	COG1321@1|root,arCOG02099@2157|Archaea,2Y7CA@28890|Euryarchaeota,242GR@183967|Thermoplasmata	183967|Thermoplasmata	K	Helix-turn-helix diphteria tox regulatory element	-	-	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,FeoA
MMS3_k127_3810158_53	416591.Tlet_0840	1.696e-20	97.0	COG1853@1|root,COG1853@2|Bacteria,2GE3B@200918|Thermotogae	200918|Thermotogae	S	PFAM flavin reductase domain protein FMN-binding	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
MMS3_k127_3810158_23	273075.Ta0378	6.586e-79	272.0	COG0681@1|root,arCOG01739@2157|Archaea,2Y79C@28890|Euryarchaeota,241T8@183967|Thermoplasmata	183967|Thermoplasmata	U	Signal peptidase	-	-	3.4.21.89	ko:K13280	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	-
MMS3_k127_3810158_67	263820.PTO0921	0.000233	51.0	COG3432@1|root,arCOG01063@2157|Archaea	2157|Archaea	K	Winged helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HTH_45
MMS3_k127_3810158_26	431943.CKL_1351	1.444e-77	266.0	COG1117@1|root,COG1117@2|Bacteria,1TP1M@1239|Firmicutes,247RD@186801|Clostridia,36DJ4@31979|Clostridiaceae	186801|Clostridia	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
MMS3_k127_3810158_40	1382304.JNIL01000001_gene3013	1.98e-44	173.0	COG0581@1|root,COG0581@2|Bacteria,1TP74@1239|Firmicutes,4HAKF@91061|Bacilli,279AY@186823|Alicyclobacillaceae	91061|Bacilli	P	TIGRFAM phosphate ABC transporter, inner membrane subunit PstA	pstA	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
MMS3_k127_3810158_33	1408418.JNJH01000006_gene1253	5.22e-58	214.0	COG0573@1|root,COG0573@2|Bacteria,1MVKP@1224|Proteobacteria,2TQU1@28211|Alphaproteobacteria,2JQK1@204441|Rhodospirillales	204441|Rhodospirillales	P	probably responsible for the translocation of the substrate across the membrane	pstC	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1,DUF3708
MMS3_k127_3810158_29	637389.Acaty_c1146	1.843e-72	257.0	COG0226@1|root,COG0226@2|Bacteria,1R9S4@1224|Proteobacteria,1SJT9@1236|Gammaproteobacteria,2NCGA@225057|Acidithiobacillales	225057|Acidithiobacillales	P	Part of the ABC transporter complex PstSACB involved in phosphate import	-	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
MMS3_k127_3810158_24	273116.14324306	3.953e-78	269.0	COG1576@1|root,arCOG00502@2157|Archaea,2XZ8Z@28890|Euryarchaeota,241TX@183967|Thermoplasmata	183967|Thermoplasmata	J	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
MMS3_k127_3810158_65	604354.TSIB_1586	5.332e-05	45.0	COG1011@1|root,arCOG02291@2157|Archaea,2Y2J0@28890|Euryarchaeota,2430U@183968|Thermococci	183968|Thermococci	S	HAD-hyrolase-like	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
MMS3_k127_3810158_63	273116.14324330	6.716e-07	54.0	COG2104@1|root,arCOG00535@2157|Archaea,2Y5Q5@28890|Euryarchaeota,242FE@183967|Thermoplasmata	183967|Thermoplasmata	H	ThiS family	-	-	-	-	-	-	-	-	-	-	-	-	ThiS
MMS3_k127_3810158_16	273116.14324331	1.303e-110	371.0	COG1746@1|root,arCOG04249@2157|Archaea,2XT5J@28890|Euryarchaeota,241NH@183967|Thermoplasmata	183967|Thermoplasmata	J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate	cca	-	2.7.7.72	ko:K07558	-	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko01000,ko03016	-	-	-	NTP_transf_2,tRNA_NucTransf2
MMS3_k127_3810158_44	273116.14324332	2.97e-40	152.0	COG1308@1|root,arCOG04061@2157|Archaea,2XXYV@28890|Euryarchaeota,241VM@183967|Thermoplasmata	183967|Thermoplasmata	J	Contacts the emerging nascent chain on the ribosome	nac	-	-	ko:K03626	-	-	-	-	ko00000	-	-	-	NAC
MMS3_k127_3810158_34	273075.Ta1186	7.492e-58	207.0	COG2345@1|root,arCOG01692@2157|Archaea	2157|Archaea	K	HTH domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
MMS3_k127_3810158_54	380394.Lferr_2097	1.755e-19	93.0	2E48M@1|root,32Z4G@2|Bacteria,1N6NZ@1224|Proteobacteria,1T8S2@1236|Gammaproteobacteria,2NDBV@225057|Acidithiobacillales	225057|Acidithiobacillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_3810158_64	161156.JQKW01000007_gene812	8.475e-07	53.0	COG1872@1|root,COG1872@2|Bacteria,2GI49@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	Uncharacterised ACR, YggU family COG1872	-	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
MMS3_k127_3810158_3	1313301.AUGC01000008_gene468	9.68e-183	592.0	COG3590@1|root,COG3590@2|Bacteria,4NEYB@976|Bacteroidetes	976|Bacteroidetes	O	peptidase family M13	pepO	-	-	ko:K07386	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M13,Peptidase_M13_N
MMS3_k127_3810158_35	1200792.AKYF01000027_gene330	2.71e-55	199.0	COG1670@1|root,COG1670@2|Bacteria,1V74P@1239|Firmicutes,4HJ7B@91061|Bacilli,272QN@186822|Paenibacillaceae	91061|Bacilli	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
MMS3_k127_3810158_66	272569.rrnAC0325	0.0001136	52.0	arCOG04567@1|root,arCOG04567@2157|Archaea,2XWK3@28890|Euryarchaeota,23VF6@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_3810158_49	1122182.KB903839_gene957	1.508e-26	113.0	COG3324@1|root,COG3324@2|Bacteria,2IRXF@201174|Actinobacteria,4DEWK@85008|Micromonosporales	201174|Actinobacteria	S	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	Glyoxalase
MMS3_k127_3810158_51	1343739.PAP_08680	8.544e-23	110.0	arCOG11292@1|root,arCOG11292@2157|Archaea,2Y3FT@28890|Euryarchaeota,2443S@183968|Thermococci	183968|Thermococci	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_3810158_59	1121899.Q764_12255	2.267e-12	73.0	COG3631@1|root,COG3631@2|Bacteria,4NTMZ@976|Bacteroidetes,1I61G@117743|Flavobacteriia,2NWYB@237|Flavobacterium	976|Bacteroidetes	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
MMS3_k127_3853280_15	273075.Ta0403	1.87e-41	157.0	COG0543@1|root,arCOG02199@2157|Archaea,2XSY9@28890|Euryarchaeota,241P3@183967|Thermoplasmata	183967|Thermoplasmata	F	Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(	pyrK	-	-	ko:K02823	ko00240,ko01100,map00240,map01100	-	-	-	ko00000,ko00001	-	-	-	DHODB_Fe-S_bind
MMS3_k127_3853280_7	273075.Ta0404	2.334e-118	388.0	COG0167@1|root,arCOG00603@2157|Archaea,2XTMB@28890|Euryarchaeota,241MJ@183967|Thermoplasmata	183967|Thermoplasmata	F	Catalyzes the conversion of dihydroorotate to orotate	pyrD	-	1.3.1.14	ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
MMS3_k127_3853280_24	273116.14324718	1.148e-19	95.0	arCOG05325@1|root,arCOG05325@2157|Archaea,2Y5Z7@28890|Euryarchaeota,242GD@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_3853280_1	263820.PTO1346	5.615e-221	695.0	COG1243@1|root,arCOG01361@2157|Archaea,2XT9Z@28890|Euryarchaeota,241K5@183967|Thermoplasmata	183967|Thermoplasmata	K	Radical_SAM C-terminal domain	-	-	2.3.1.48	ko:K07739	-	-	-	-	ko00000,ko01000,ko03016,ko03036	-	-	-	Acetyltransf_1,Radical_SAM,Radical_SAM_C
MMS3_k127_3853280_2	273075.Ta0456m	2.57e-192	608.0	COG0281@1|root,arCOG00853@2157|Archaea,2XSTN@28890|Euryarchaeota,241JH@183967|Thermoplasmata	183967|Thermoplasmata	C	Malic enzyme, NAD binding domain	-	-	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	-	R00214	RC00105	ko00000,ko00001,ko01000	-	-	-	Malic_M,malic
MMS3_k127_3853280_18	572478.Vdis_0835	2.077e-37	145.0	COG0454@1|root,arCOG00826@2157|Archaea,2XR3W@28889|Crenarchaeota	28889|Crenarchaeota	K	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
MMS3_k127_3853280_22	273075.Ta0457	1.538e-26	121.0	COG0454@1|root,arCOG00846@2157|Archaea,2Y7B4@28890|Euryarchaeota,2429P@183967|Thermoplasmata	183967|Thermoplasmata	K	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
MMS3_k127_3853280_21	273116.14325556	7.921e-28	124.0	COG0170@1|root,arCOG01880@2157|Archaea,2Y7B2@28890|Euryarchaeota,2429J@183967|Thermoplasmata	183967|Thermoplasmata	I	PFAM phosphatidate cytidylyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_3853280_29	263820.PTO1276	2.788e-08	62.0	arCOG05402@1|root,arCOG05402@2157|Archaea,2Y4HZ@28890|Euryarchaeota,242E2@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_3853280_16	263820.PTO0984	6.119e-39	148.0	COG2007@1|root,arCOG04154@2157|Archaea,2XYXX@28890|Euryarchaeota,241T7@183967|Thermoplasmata	183967|Thermoplasmata	J	structural constituent of ribosome	rps8e	-	-	ko:K02995	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8e
MMS3_k127_3853280_23	273075.Ta1039	2.269e-20	95.0	COG1400@1|root,arCOG01217@2157|Archaea,2Y5W9@28890|Euryarchaeota,242GT@183967|Thermoplasmata	183967|Thermoplasmata	U	SRP19 protein	-	-	-	ko:K03105	ko03060,map03060	-	-	-	ko00000,ko00001,ko02044	3.A.5.7,3.A.5.9	-	-	SRP19
MMS3_k127_3853280_13	273116.14324771	9.039e-54	201.0	COG2219@1|root,arCOG03013@2157|Archaea,2XTDT@28890|Euryarchaeota,241UK@183967|Thermoplasmata	183967|Thermoplasmata	L	Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair	priL	-	-	ko:K18882	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_primase_lrg
MMS3_k127_3853280_4	263820.PTO0981	2.675e-141	456.0	COG0006@1|root,arCOG01000@2157|Archaea,2XTI9@28890|Euryarchaeota,241MH@183967|Thermoplasmata	183967|Thermoplasmata	E	Metallopeptidase family M24	-	-	3.4.13.9	ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
MMS3_k127_3853280_12	273075.Ta1359	1.957e-58	209.0	COG0602@1|root,arCOG02173@2157|Archaea,2XUSP@28890|Euryarchaeota,241VU@183967|Thermoplasmata	183967|Thermoplasmata	H	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds	queE	-	4.3.99.3	ko:K10026	ko00790,ko01100,map00790,map01100	-	R10002	RC02989	ko00000,ko00001,ko01000,ko03016	-	-	-	Fer4_14,Radical_SAM
MMS3_k127_3853280_6	273075.Ta1319	1.192e-126	418.0	COG0044@1|root,arCOG00689@2157|Archaea,2XTQU@28890|Euryarchaeota,241MY@183967|Thermoplasmata	183967|Thermoplasmata	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	pyrC	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
MMS3_k127_3853280_28	273116.14324496	2.745e-14	76.0	COG2023@1|root,arCOG04345@2157|Archaea,2Y7CC@28890|Euryarchaeota,242HS@183967|Thermoplasmata	183967|Thermoplasmata	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp4	-	3.1.26.5	ko:K03540	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	-
MMS3_k127_3853280_19	273075.Ta0177	4.897e-34	131.0	arCOG05238@1|root,arCOG05238@2157|Archaea,2Y0YG@28890|Euryarchaeota,242C6@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_3853280_9	263820.PTO1429	3.039e-77	269.0	COG0350@1|root,COG1515@1|root,arCOG00929@2157|Archaea,arCOG02724@2157|Archaea,2XURE@28890|Euryarchaeota,24279@183967|Thermoplasmata	183967|Thermoplasmata	L	DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA (By similarity)	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	3.1.21.7	ko:K05982	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1,Endonuclease_5
MMS3_k127_3853280_26	263820.PTO0863	1.645e-15	78.0	arCOG05368@1|root,arCOG05368@2157|Archaea,2Y1EG@28890|Euryarchaeota,241W5@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_3853280_27	673860.AciM339_0463	1.601e-14	81.0	COG3398@1|root,arCOG02611@2157|Archaea,2XWAQ@28890|Euryarchaeota,3F3BI@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_24,HTH_5
MMS3_k127_3853280_0	273075.Ta0587	0.0	1594.0	COG1201@1|root,arCOG00557@2157|Archaea,2XSTH@28890|Euryarchaeota,241JN@183967|Thermoplasmata	183967|Thermoplasmata	K	DEAD/H associated	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
MMS3_k127_3853280_8	273116.14324694	1.629e-108	362.0	COG1415@1|root,arCOG04253@2157|Archaea,2XU0W@28890|Euryarchaeota,241YK@183967|Thermoplasmata	183967|Thermoplasmata	S	Protein of unknown function (DUF763)	-	-	-	ko:K09003	-	-	-	-	ko00000	-	-	-	DUF763
MMS3_k127_3853280_25	263820.PTO0870	8.89e-19	87.0	COG1998@1|root,arCOG04183@2157|Archaea,2XZZ0@28890|Euryarchaeota,241WR@183967|Thermoplasmata	183967|Thermoplasmata	J	Belongs to the eukaryotic ribosomal protein eS31 family	rps27ae	-	-	ko:K02977	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko04147	-	-	-	Ribosomal_S27
MMS3_k127_3853280_20	273116.14324697	6.342e-29	118.0	COG2004@1|root,arCOG04182@2157|Archaea,2Y7BU@28890|Euryarchaeota,242EA@183967|Thermoplasmata	183967|Thermoplasmata	J	structural constituent of ribosome	rps24e	-	-	ko:K02974	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S24e
MMS3_k127_3853280_17	273116.14324698	7.592e-38	148.0	COG1909@1|root,arCOG04076@2157|Archaea,2XXSG@28890|Euryarchaeota,241XB@183967|Thermoplasmata	183967|Thermoplasmata	S	Protein of unknown function (DUF359)	-	-	-	ko:K09735	-	-	-	-	ko00000	-	-	-	DUF359
MMS3_k127_3853280_10	273116.14324700	3.333e-72	248.0	COG1095@1|root,arCOG00675@2157|Archaea,2XT6U@28890|Euryarchaeota,241RJ@183967|Thermoplasmata	183967|Thermoplasmata	K	SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397	-	-	2.7.7.6	ko:K03049	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	S1,SHS2_Rpb7-N
MMS3_k127_3853280_3	273116.14325531	3.428e-148	478.0	COG1960@1|root,arCOG01707@2157|Archaea,2XSVA@28890|Euryarchaeota,2421G@183967|Thermoplasmata	183967|Thermoplasmata	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.4	ko:K00253	ko00280,ko01100,map00280,map01100	M00036	R04095	RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
MMS3_k127_3853280_14	263820.PTO1421	4.05e-45	176.0	COG1499@1|root,arCOG04149@2157|Archaea,2XUAI@28890|Euryarchaeota,241U8@183967|Thermoplasmata	183967|Thermoplasmata	J	NMD3 family	-	-	-	ko:K07562	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko03009	-	-	-	NMD3
MMS3_k127_3853280_5	273116.14324691	1.132e-136	447.0	COG2235@1|root,arCOG03108@2157|Archaea,2XX08@28890|Euryarchaeota,241XU@183967|Thermoplasmata	183967|Thermoplasmata	E	Amidinotransferase	-	-	3.5.3.6	ko:K01478	ko00220,ko01100,ko01110,ko01130,map00220,map01100,map01110,map01130	-	R00552	RC00177	ko00000,ko00001,ko01000	-	-	-	Amidinotransf
MMS3_k127_3853280_11	263820.PTO1524	1.242e-67	235.0	COG1890@1|root,arCOG04186@2157|Archaea,2XSX9@28890|Euryarchaeota,241QV@183967|Thermoplasmata	183967|Thermoplasmata	J	structural constituent of ribosome	rps3ae	-	-	ko:K02984	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S3Ae
MMS3_k127_3887313_0	1385513.N780_05520	8.112e-40	153.0	2DNQ8@1|root,32YJ3@2|Bacteria,1VXNK@1239|Firmicutes,4HXD0@91061|Bacilli,2YAZG@289201|Pontibacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_3897096_1	273075.Ta1156	9.373e-119	389.0	arCOG06008@1|root,arCOG06008@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_3897096_8	273075.Ta0842	4.61e-35	138.0	COG1321@1|root,arCOG02100@2157|Archaea,2Y7B9@28890|Euryarchaeota,242AG@183967|Thermoplasmata	183967|Thermoplasmata	K	Iron dependent repressor, metal binding and dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	Fe_dep_repr_C,Fe_dep_repress
MMS3_k127_3897096_4	263820.PTO0637	1.669e-69	238.0	COG0652@1|root,arCOG04767@2157|Archaea,2XTHC@28890|Euryarchaeota,242AD@183967|Thermoplasmata	183967|Thermoplasmata	O	Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD	-	-	5.2.1.8	ko:K01802	-	-	-	-	ko00000,ko01000	-	-	-	Pro_isomerase
MMS3_k127_3897096_2	397948.Cmaq_0176	1.383e-107	371.0	COG0038@1|root,arCOG02569@2157|Archaea,2XQ0P@28889|Crenarchaeota	28889|Crenarchaeota	P	PFAM CBS domain	-	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	-	CBS,Voltage_CLC
MMS3_k127_3897096_5	273075.Ta1353m	9.166e-66	228.0	COG1839@1|root,arCOG04298@2157|Archaea,2XY40@28890|Euryarchaeota,2426Q@183967|Thermoplasmata	183967|Thermoplasmata	L	Adenosine specific kinase	-	-	-	ko:K09129	-	-	-	-	ko00000	-	-	-	Adenosine_kin
MMS3_k127_3897096_10	1304866.K413DRAFT_3581	3.204e-11	71.0	COG0454@1|root,COG0456@2|Bacteria,1V2CK@1239|Firmicutes,24KFX@186801|Clostridia,36MGM@31979|Clostridiaceae	186801|Clostridia	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
MMS3_k127_3897096_0	439481.Aboo_1300	4.397e-144	470.0	COG1363@1|root,arCOG01518@2157|Archaea,2XW74@28890|Euryarchaeota,3F2FY@33867|unclassified Euryarchaeota	28890|Euryarchaeota	G	Aminopeptidase I zinc metalloprotease (M18)	-	-	3.4.11.21	ko:K01267	-	-	-	-	ko00000,ko01000,ko01002,ko04131	-	-	-	Peptidase_M18
MMS3_k127_3897096_7	66692.ABC0288	1.314e-45	171.0	COG0563@1|root,COG0563@2|Bacteria,1V7AW@1239|Firmicutes,4HH8A@91061|Bacilli,1ZHDW@1386|Bacillus	91061|Bacilli	F	topology modulation protein	flaR	-	-	-	-	-	-	-	-	-	-	-	AAA_18,ABC_tran
MMS3_k127_3897096_3	439481.Aboo_0868	9.122e-85	288.0	COG1028@1|root,arCOG01259@2157|Archaea,2XTYG@28890|Euryarchaeota	28890|Euryarchaeota	I	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
MMS3_k127_3897096_12	1246995.AFR_16395	7.002e-05	48.0	28Z5Z@1|root,2ZKY9@2|Bacteria,2H8K9@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_3897096_9	224325.AF_2012	7.509e-25	108.0	COG1848@1|root,arCOG00713@2157|Archaea,2Y6EB@28890|Euryarchaeota,24753@183980|Archaeoglobi	183980|Archaeoglobi	V	Large family of predicted nucleotide-binding domains	-	-	-	ko:K07064	-	-	-	-	ko00000	-	-	-	PIN
MMS3_k127_3897096_11	589924.Ferp_1797	1.681e-05	50.0	arCOG00818@1|root,arCOG00818@2157|Archaea	2157|Archaea	S	AbrB family	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin
MMS3_k127_3897096_6	1464048.JNZS01000010_gene5292	5.42e-46	174.0	COG2230@1|root,COG2230@2|Bacteria,2I82K@201174|Actinobacteria,4DE98@85008|Micromonosporales	201174|Actinobacteria	M	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_12,Methyltransf_25,Methyltransf_31
MMS3_k127_3921495_6	263820.PTO1091	6.533e-124	402.0	COG0024@1|root,arCOG01001@2157|Archaea,2XT8G@28890|Euryarchaeota,241PI@183967|Thermoplasmata	183967|Thermoplasmata	E	Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val)	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
MMS3_k127_3921495_16	436308.Nmar_1567	2.032e-51	192.0	COG0077@1|root,arCOG00255@2157|Archaea,41SA8@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Prephenate dehydratase	-	-	4.2.1.51	ko:K04518	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024	R00691,R01373	RC00360	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,PDT
MMS3_k127_3921495_24	935836.JAEL01000053_gene4879	3.268e-24	110.0	COG1443@1|root,COG1443@2|Bacteria,1V6SB@1239|Firmicutes,4HJ2T@91061|Bacilli,1ZFNY@1386|Bacillus	91061|Bacilli	I	COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes	M1-740	-	-	-	-	-	-	-	-	-	-	-	NUDIX
MMS3_k127_3921495_11	273116.14325151	6.688e-87	297.0	COG0596@1|root,arCOG01648@2157|Archaea,2XY7B@28890|Euryarchaeota,242EV@183967|Thermoplasmata	183967|Thermoplasmata	E	Cleaves H-Pro-AMC as well as a wide spectrum of amino acid substrates and several peptide substrates without a proline at the N-terminus	pip	-	3.4.11.5	ko:K01259	ko00330,map00330	-	R00135	-	ko00000,ko00001,ko01000,ko01002	-	-	-	-
MMS3_k127_3921495_25	273116.14325611	2.807e-23	103.0	COG0599@1|root,arCOG02148@2157|Archaea,2Y01N@28890|Euryarchaeota,242D9@183967|Thermoplasmata	183967|Thermoplasmata	S	Carboxymuconolactone decarboxylase family	-	-	-	-	-	-	-	-	-	-	-	-	CMD
MMS3_k127_3921495_22	273116.14325275	6.33e-29	121.0	COG3439@1|root,arCOG02761@2157|Archaea,2Y7BY@28890|Euryarchaeota,242F7@183967|Thermoplasmata	183967|Thermoplasmata	S	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	DUF302
MMS3_k127_3921495_9	263820.PTO0627	1.488e-95	318.0	COG0708@1|root,arCOG02207@2157|Archaea,2XVJ5@28890|Euryarchaeota,241XM@183967|Thermoplasmata	183967|Thermoplasmata	L	Endonuclease/Exonuclease/phosphatase family	-	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
MMS3_k127_3921495_27	1121090.KB894685_gene3412	4.086e-18	97.0	COG2271@1|root,COG2271@2|Bacteria,1V0VC@1239|Firmicutes,4HC5B@91061|Bacilli,1ZD8A@1386|Bacillus	91061|Bacilli	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS3_k127_3921495_23	263820.PTO0871	1.655e-26	111.0	COG4847@1|root,arCOG00317@2157|Archaea,2Y4P1@28890|Euryarchaeota,242CH@183967|Thermoplasmata	183967|Thermoplasmata	S	Uncharacterized protein conserved in archaea (DUF2175)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2175
MMS3_k127_3921495_14	273075.Ta0226	2.462e-61	220.0	COG0842@1|root,arCOG01467@2157|Archaea,2XT3B@28890|Euryarchaeota,2429G@183967|Thermoplasmata	183967|Thermoplasmata	V	ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
MMS3_k127_3921495_8	273116.14325631	3.065e-96	324.0	COG1131@1|root,arCOG00194@2157|Archaea,2XT0T@28890|Euryarchaeota,24233@183967|Thermoplasmata	183967|Thermoplasmata	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
MMS3_k127_3921495_32	671065.MetMK1DRAFT_00015180	2.656e-05	59.0	arCOG06052@1|root,arCOG06052@2157|Archaea,2XSHA@28889|Crenarchaeota	28889|Crenarchaeota	S	parallel beta-helix repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_3921495_7	273116.14325760	1.714e-114	415.0	COG4934@1|root,arCOG03665@2157|Archaea	2157|Archaea	O	tripeptidyl-peptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	CHB_HEX_C_1
MMS3_k127_3921495_0	273116.14325530	2.059e-229	726.0	COG0365@1|root,arCOG01529@2157|Archaea,2XTEH@28890|Euryarchaeota	28890|Euryarchaeota	I	COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases	acs1	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
MMS3_k127_3921495_17	273116.14324397	1.13e-47	181.0	COG0491@1|root,arCOG00511@2157|Archaea,2Y3Q7@28890|Euryarchaeota,2428Y@183967|Thermoplasmata	183967|Thermoplasmata	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
MMS3_k127_3921495_10	273075.Ta0110	9.08e-92	311.0	COG0704@1|root,arCOG00318@2157|Archaea,2XUA4@28890|Euryarchaeota,2423S@183967|Thermoplasmata	183967|Thermoplasmata	K	SpoVT / AbrB like domain	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin,PhoU
MMS3_k127_3921495_29	263820.PTO0567	6.329e-15	84.0	arCOG07356@1|root,arCOG07356@2157|Archaea,2Y629@28890|Euryarchaeota,242F0@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_3921495_12	263820.PTO1105	1.663e-75	258.0	COG3620@1|root,arCOG00608@2157|Archaea,2XTDG@28890|Euryarchaeota,241RM@183967|Thermoplasmata	183967|Thermoplasmata	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,HTH_3
MMS3_k127_3921495_15	273116.14324401	5.819e-53	192.0	COG0575@1|root,arCOG04106@2157|Archaea,2XWNR@28890|Euryarchaeota,241V9@183967|Thermoplasmata	183967|Thermoplasmata	I	Catalyzes the formation of CDP-2,3-bis-(O- geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O- geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids	carS	-	2.7.7.67	ko:K19664	ko00564,map00564	-	R08966	RC00002	ko00000,ko00001,ko01000	-	-	-	CarS-like
MMS3_k127_3921495_21	263820.PTO1103	1.208e-31	129.0	COG1990@1|root,arCOG04228@2157|Archaea,2XYRE@28890|Euryarchaeota,241UF@183967|Thermoplasmata	183967|Thermoplasmata	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	-	3.1.1.29	ko:K04794	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	PTH2
MMS3_k127_3921495_3	263820.PTO0247	1.755e-135	437.0	COG1619@1|root,arCOG04676@2157|Archaea,2Y78V@28890|Euryarchaeota,2420J@183967|Thermoplasmata	183967|Thermoplasmata	V	LD-carboxypeptidase	-	-	3.4.17.13	ko:K01297	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_S66
MMS3_k127_3921495_5	263820.PTO0246	1.377e-132	433.0	COG1473@1|root,arCOG01108@2157|Archaea,2XUUS@28890|Euryarchaeota,2423B@183967|Thermoplasmata	183967|Thermoplasmata	S	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer
MMS3_k127_3921495_4	273075.Ta0080	7.989e-133	434.0	COG0626@1|root,arCOG00060@2157|Archaea,2XT98@28890|Euryarchaeota,241P8@183967|Thermoplasmata	183967|Thermoplasmata	E	Cys/Met metabolism PLP-dependent enzyme	-	-	2.5.1.48,4.4.1.1	ko:K01739,ko:K01758	ko00260,ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00260,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017,M00338	R00782,R00999,R01001,R01288,R02408,R02508,R03217,R03260,R04770,R04930,R04944,R04945,R04946,R09366	RC00020,RC00056,RC00069,RC00348,RC00382,RC00420,RC00710,RC01209,RC01210,RC01245,RC02303,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Cys_Met_Meta_PP
MMS3_k127_3921495_20	273075.Ta0081	7.17e-32	133.0	COG0125@1|root,arCOG01891@2157|Archaea,2XTAM@28890|Euryarchaeota,241UQ@183967|Thermoplasmata	183967|Thermoplasmata	F	dTDP metabolic process	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
MMS3_k127_3921495_13	273116.14324329	1.275e-71	249.0	COG1938@1|root,arCOG00347@2157|Archaea,2XT93@28890|Euryarchaeota,242F5@183967|Thermoplasmata	183967|Thermoplasmata	S	PAC2 family	-	-	-	ko:K06869	-	-	-	-	ko00000	-	-	-	PAC2
MMS3_k127_3921495_19	485918.Cpin_5720	1.452e-38	145.0	2C82G@1|root,32RK9@2|Bacteria,4NSXV@976|Bacteroidetes,1IYD5@117747|Sphingobacteriia	976|Bacteroidetes	S	Protein of unknown function (DUF4242)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4242
MMS3_k127_3921495_2	386456.JQKN01000002_gene2473	3.115e-180	574.0	COG0076@1|root,arCOG00027@2157|Archaea,2XWF7@28890|Euryarchaeota	28890|Euryarchaeota	E	TIGRFAM Glutamate decarboxylase	-	-	4.1.1.15	ko:K01580	ko00250,ko00410,ko00430,ko00650,ko01100,ko01110,ko01120,ko02024,ko04727,ko04940,map00250,map00410,map00430,map00650,map01100,map01110,map01120,map02024,map04727,map04940	M00027	R00261,R00489,R01682,R02466	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Pyridoxal_deC
MMS3_k127_3921495_30	273116.14325437	2.195e-14	77.0	arCOG05383@1|root,arCOG05383@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_3921495_1	263820.PTO0164	3.453e-189	614.0	COG2217@1|root,arCOG01576@2157|Archaea,2XT3T@28890|Euryarchaeota,241II@183967|Thermoplasmata	183967|Thermoplasmata	P	YHS domain	-	-	3.6.3.4	ko:K01533	-	-	R00086	RC00002	ko00000,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hydrolase,YHS
MMS3_k127_3921495_31	529709.PYCH_08970	1.788e-10	62.0	COG3350@1|root,arCOG04507@2157|Archaea,2Y1MF@28890|Euryarchaeota,244R8@183968|Thermococci	183968|Thermococci	S	YHS domain	-	-	-	-	-	-	-	-	-	-	-	-	YHS
MMS3_k127_3921495_26	273075.Ta1218	4.049e-20	96.0	COG1522@1|root,arCOG01585@2157|Archaea,2XYZV@28890|Euryarchaeota,242G8@183967|Thermoplasmata	183967|Thermoplasmata	K	Archaeal TRASH domain	-	-	-	-	-	-	-	-	-	-	-	-	Arc_trans_TRASH,HTH_24
MMS3_k127_3921495_18	273075.Ta1236	8.246e-39	153.0	arCOG07408@1|root,arCOG07408@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_3921495_28	387631.Asulf_00955	6.992e-18	91.0	arCOG07100@1|root,arCOG07100@2157|Archaea,2XZZK@28890|Euryarchaeota,2470E@183980|Archaeoglobi	183980|Archaeoglobi	S	Protein of unknown function (DUF3800)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3800
MMS3_k127_40124_9	273116.14324413	1.073e-34	146.0	COG2971@1|root,arCOG03659@2157|Archaea,2Y02S@28890|Euryarchaeota,2428D@183967|Thermoplasmata	183967|Thermoplasmata	G	BadF/BadG/BcrA/BcrD ATPase family	-	-	2.7.1.59	ko:K00884	ko00520,ko01100,map00520,map01100	-	R01201	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	BcrAD_BadFG
MMS3_k127_40124_6	1196028.ALEF01000016_gene2657	1.781e-65	237.0	COG3876@1|root,COG3876@2|Bacteria,1VRMG@1239|Firmicutes,4HA8F@91061|Bacilli,4C6EN@84406|Virgibacillus	91061|Bacilli	S	Protein of unknown function (DUF1343)	ybbC	-	-	-	-	-	-	-	-	-	-	-	DUF1343
MMS3_k127_40124_1	263820.PTO0021	5.079e-103	346.0	COG4948@1|root,arCOG01168@2157|Archaea,2XUAK@28890|Euryarchaeota	28890|Euryarchaeota	M	COG4948 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily	ykfB2	-	5.1.1.20	ko:K19802	-	-	R10938	RC03309	ko00000,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
MMS3_k127_40124_11	673860.AciM339_0035	2.63e-09	67.0	arCOG00828@1|root,arCOG00828@2157|Archaea,2Y6YR@28890|Euryarchaeota,3F2XN@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_40124_3	263820.PTO0020	9.283e-94	324.0	COG1472@1|root,arCOG04634@2157|Archaea,2XTGV@28890|Euryarchaeota	28890|Euryarchaeota	G	COG1472 Beta-glucosidase-related glycosidases	-	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3,Glyco_hydro_3_C
MMS3_k127_40124_0	1118054.CAGW01000082_gene3042	4.171e-177	571.0	COG2936@1|root,COG2936@2|Bacteria,1TT0H@1239|Firmicutes,4HC37@91061|Bacilli,26TMF@186822|Paenibacillaceae	91061|Bacilli	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
MMS3_k127_40124_4	263820.PTO0019	2.135e-75	266.0	COG1680@1|root,arCOG00771@2157|Archaea	2157|Archaea	V	COG1680 Beta-lactamase class C and other penicillin binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
MMS3_k127_40124_8	1304284.L21TH_1855	5.803e-58	211.0	COG2103@1|root,COG2103@2|Bacteria,1TPSF@1239|Firmicutes,247KZ@186801|Clostridia,36FJV@31979|Clostridiaceae	186801|Clostridia	G	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate	murQ	-	4.2.1.126	ko:K07106	ko00520,ko01100,map00520,map01100	-	R08555	RC00397,RC00746	ko00000,ko00001,ko01000	-	-	-	SIS,SIS_2
MMS3_k127_40124_5	591019.Shell_0921	1.812e-73	261.0	COG1820@1|root,arCOG00699@2157|Archaea,2XPM6@28889|Crenarchaeota	28889|Crenarchaeota	G	N-acetylglucosamine-6-phosphate deacetylase	nagA	-	3.5.1.25	ko:K01443	ko00520,ko01130,map00520,map01130	-	R02059	RC00166,RC00300	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
MMS3_k127_40124_10	747365.Thena_0791	3.817e-24	114.0	COG0449@1|root,COG0449@2|Bacteria,1TPGU@1239|Firmicutes,248F8@186801|Clostridia,42EKN@68295|Thermoanaerobacterales	186801|Clostridia	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
MMS3_k127_40124_7	263820.PTO0017	1.976e-60	216.0	COG0791@1|root,2N59G@2157|Archaea,2XWZY@28890|Euryarchaeota	28890|Euryarchaeota	M	NlpC/P60 family	-	-	-	-	-	-	-	-	-	-	-	-	NLPC_P60,SH3_3
MMS3_k127_40124_2	397948.Cmaq_1232	4.297e-94	317.0	COG2377@1|root,2N56F@2157|Archaea	2157|Archaea	O	Anhydro-N-acetylmuramic acid kinase	-	-	2.7.1.170	ko:K09001	-	-	-	-	ko00000,ko01000	-	-	-	AnmK
MMS3_k127_4062374_83	1305836.AXVE01000016_gene1999	7.403e-48	177.0	COG0406@1|root,COG0406@2|Bacteria,1V7F8@1239|Firmicutes,4HIR1@91061|Bacilli,26FAU@186818|Planococcaceae	91061|Bacilli	G	Phosphoglycerate mutase family	gpmA1	-	5.4.2.11	ko:K01834	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	His_Phos_1
MMS3_k127_4062374_119	189426.PODO_21640	1.571e-21	102.0	COG0262@1|root,COG0262@2|Bacteria,1V4F8@1239|Firmicutes,4HGWK@91061|Bacilli,26WNW@186822|Paenibacillaceae	91061|Bacilli	H	RibD C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
MMS3_k127_4062374_116	523841.HFX_1420	2.68e-26	113.0	arCOG02998@1|root,arCOG02998@2157|Archaea,2Y60T@28890|Euryarchaeota,240R7@183963|Halobacteria	183963|Halobacteria	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
MMS3_k127_4062374_73	1007103.AFHW01000036_gene1823	2.874e-58	206.0	COG0454@1|root,COG0456@2|Bacteria,1V50M@1239|Firmicutes,4HH63@91061|Bacilli,26XZ2@186822|Paenibacillaceae	91061|Bacilli	K	Acetyltransferase (GNAT) family	yqjY	GO:0003674,GO:0003824,GO:0006464,GO:0006473,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564	-	ko:K06977	-	-	-	-	ko00000	-	-	-	Acetyltransf_1
MMS3_k127_4062374_1	273116.14325620	2.683e-298	922.0	COG2987@1|root,arCOG04670@2157|Archaea,2XT9Q@28890|Euryarchaeota,24215@183967|Thermoplasmata	183967|Thermoplasmata	E	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate	hutU	-	4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000	-	-	-	Urocanase,Urocanase_C,Urocanase_N
MMS3_k127_4062374_123	1459636.NTE_00024	2.083e-14	78.0	COG5485@1|root,arCOG06513@2157|Archaea	2157|Archaea	S	ester cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL,SnoaL_2
MMS3_k127_4062374_87	649747.HMPREF0083_02280	6.171e-47	181.0	COG0500@1|root,COG0500@2|Bacteria	2|Bacteria	Q	methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_12,Methyltransf_25
MMS3_k127_4062374_126	1380390.JIAT01000011_gene2642	1.565e-11	73.0	2AV0E@1|root,31KQ8@2|Bacteria,2HPHG@201174|Actinobacteria,4CQVP@84995|Rubrobacteria	84995|Rubrobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_4062374_97	391596.PBAL39_16896	1.071e-38	151.0	COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria,4NESR@976|Bacteroidetes,1IQI9@117747|Sphingobacteriia	976|Bacteroidetes	L	DNA ligase	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
MMS3_k127_4062374_125	1343739.PAP_07285	1.01e-13	84.0	arCOG04615@1|root,arCOG04615@2157|Archaea,2Y2IE@28890|Euryarchaeota,244Z1@183968|Thermococci	183968|Thermococci	S	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
MMS3_k127_4062374_103	671065.MetMK1DRAFT_00013170	5.689e-34	135.0	COG4911@1|root,arCOG05495@2157|Archaea,2XSGC@28889|Crenarchaeota	28889|Crenarchaeota	S	Uncharacterized conserved protein (DUF2203)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2203
MMS3_k127_4062374_32	1209989.TepiRe1_0900	5.022e-121	401.0	COG0863@1|root,COG0863@2|Bacteria	2|Bacteria	L	N-4 methylation of cytosine	-	-	2.1.1.113	ko:K00590	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
MMS3_k127_4062374_59	351627.Csac_0634	1.091e-72	254.0	COG0338@1|root,COG0338@2|Bacteria,1TRDX@1239|Firmicutes,25E75@186801|Clostridia,42G63@68295|Thermoanaerobacterales	186801|Clostridia	H	PFAM D12 class N6 adenine-specific DNA methyltransferase	dam	-	2.1.1.72	ko:K06223	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko02048,ko03032,ko03400	-	-	-	MethyltransfD12
MMS3_k127_4062374_84	985053.VMUT_1872	8.217e-48	177.0	COG3371@1|root,arCOG02008@2157|Archaea,2XRYZ@28889|Crenarchaeota	28889|Crenarchaeota	S	Protein of unknown function (DUF998)	-	-	-	-	-	-	-	-	-	-	-	-	DUF998
MMS3_k127_4062374_78	572478.Vdis_1942	1.431e-52	202.0	COG1721@1|root,arCOG02742@2157|Archaea	2157|Archaea	S	protein (some members contain a von Willebrand factor type A (vWA) domain)	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
MMS3_k127_4062374_31	397948.Cmaq_0910	8.489e-126	409.0	COG0714@1|root,arCOG00434@2157|Archaea,2XPMH@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM ATPase associated with various cellular activities, AAA_3	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
MMS3_k127_4062374_127	397948.Cmaq_0908	2.282e-11	76.0	arCOG07425@1|root,arCOG07425@2157|Archaea	2157|Archaea	KLT	Periplasmic copper-binding protein (NosD)	-	-	-	-	-	-	-	-	-	-	-	-	NosD,Pkinase,Transglut_core
MMS3_k127_4062374_69	273116.14325549	6.844e-60	215.0	COG0149@1|root,arCOG01087@2157|Archaea,2XTY3@28890|Euryarchaeota,241RE@183967|Thermoplasmata	183967|Thermoplasmata	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	-	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM,ThiG
MMS3_k127_4062374_96	273116.14325548	4.729e-39	156.0	arCOG02206@1|root,arCOG02206@2157|Archaea,2Y10D@28890|Euryarchaeota,242AI@183967|Thermoplasmata	183967|Thermoplasmata	S	ribosomal small subunit binding	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_4062374_23	273116.14325616	1.49e-152	497.0	COG2986@1|root,arCOG04671@2157|Archaea,2XUUM@28890|Euryarchaeota,241ZU@183967|Thermoplasmata	183967|Thermoplasmata	E	histidine ammonia-lyase activity	hutH	-	4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
MMS3_k127_4062374_3	263820.PTO0594	1.085e-244	773.0	COG0441@1|root,arCOG00401@2157|Archaea,2XTFI@28890|Euryarchaeota,241KD@183967|Thermoplasmata	183967|Thermoplasmata	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_SAD
MMS3_k127_4062374_36	273116.14325543	4.004e-113	374.0	COG2025@1|root,arCOG00447@2157|Archaea,2XT06@28890|Euryarchaeota	28890|Euryarchaeota	C	Electron transfer flavoprotein alpha subunit	-	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
MMS3_k127_4062374_49	273116.14325542	3.993e-93	312.0	COG2086@1|root,arCOG00446@2157|Archaea,2XTB8@28890|Euryarchaeota	28890|Euryarchaeota	C	Electron transfer flavoprotein, beta subunit	-	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
MMS3_k127_4062374_88	273116.14325541	5.685e-46	166.0	COG2440@1|root,arCOG01984@2157|Archaea,2XYN9@28890|Euryarchaeota,242HR@183967|Thermoplasmata	183967|Thermoplasmata	C	Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S	-	-	-	-	-	-	-	-	-	-	-	-	ETF_QO
MMS3_k127_4062374_25	273116.14325540	1.337e-146	476.0	COG0644@1|root,arCOG00570@2157|Archaea,2XV3Q@28890|Euryarchaeota,242AZ@183967|Thermoplasmata	183967|Thermoplasmata	C	FAD dependent oxidoreductase	-	-	-	ko:K00313	-	-	-	-	ko00000,ko01000	-	-	-	DAO
MMS3_k127_4062374_80	263820.PTO0593	2.008e-50	188.0	COG2231@1|root,arCOG00461@2157|Archaea,2Y86S@28890|Euryarchaeota,2428J@183967|Thermoplasmata	183967|Thermoplasmata	L	endonuclease III	-	-	-	ko:K07457	-	-	-	-	ko00000	-	-	-	HhH-GPD
MMS3_k127_4062374_10	263820.PTO0592	1.24e-193	610.0	COG3276@1|root,arCOG01563@2157|Archaea,2XUKU@28890|Euryarchaeota,241M1@183967|Thermoplasmata	183967|Thermoplasmata	J	eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA	eif2g	-	-	ko:K03242	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	GTP_EFTU,eIF2_C
MMS3_k127_4062374_82	273075.Ta0323m	5.686e-49	177.0	COG2125@1|root,arCOG01946@2157|Archaea,2XXZJ@28890|Euryarchaeota,241VJ@183967|Thermoplasmata	183967|Thermoplasmata	J	Belongs to the eukaryotic ribosomal protein eS6 family	rps6e	-	-	ko:K02991	ko01521,ko03010,ko04066,ko04150,ko04151,ko04371,ko04714,ko04910,ko05205,map01521,map03010,map04066,map04150,map04151,map04371,map04714,map04910,map05205	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S6e
MMS3_k127_4062374_14	263820.PTO0374	4.959e-182	584.0	COG0533@1|root,arCOG01183@2157|Archaea,arCOG01185@2157|Archaea,2XT07@28890|Euryarchaeota,241KF@183967|Thermoplasmata	183967|Thermoplasmata	LT	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function	-	-	2.3.1.234,2.7.11.1	ko:K15904	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko01001,ko03016	-	-	-	Kdo,Peptidase_M22
MMS3_k127_4062374_74	273116.14325539	2.524e-55	199.0	COG0127@1|root,arCOG04184@2157|Archaea,2XTS4@28890|Euryarchaeota,241VI@183967|Thermoplasmata	183967|Thermoplasmata	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	-	-	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
MMS3_k127_4062374_122	273075.Ta0354	2.768e-16	83.0	arCOG05351@1|root,arCOG05351@2157|Archaea,2Y1XZ@28890|Euryarchaeota,242GE@183967|Thermoplasmata	183967|Thermoplasmata	S	Protein of unknown function (DUF3198)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3198
MMS3_k127_4062374_30	273116.14324633	2.708e-126	408.0	COG0421@1|root,arCOG00050@2157|Archaea,2XV5K@28890|Euryarchaeota,2422Q@183967|Thermoplasmata	183967|Thermoplasmata	E	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	speE	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synt_N,Spermine_synth
MMS3_k127_4062374_99	273075.Ta0093	3.538e-37	141.0	COG0776@1|root,arCOG05336@2157|Archaea,2XZF7@28890|Euryarchaeota,242BD@183967|Thermoplasmata	183967|Thermoplasmata	L	bacterial (prokaryotic) histone like domain	-	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
MMS3_k127_4062374_26	273075.Ta1358	1.573e-145	473.0	COG0403@1|root,arCOG00077@2157|Archaea,2XT39@28890|Euryarchaeota,24213@183967|Thermoplasmata	183967|Thermoplasmata	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPA	-	1.4.4.2	ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
MMS3_k127_4062374_8	273116.14324516	7.317e-205	647.0	COG1003@1|root,arCOG00076@2157|Archaea,2XT3V@28890|Euryarchaeota,241YN@183967|Thermoplasmata	183967|Thermoplasmata	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPB	-	1.4.4.2	ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
MMS3_k127_4062374_71	263820.PTO1418	9.942e-59	213.0	COG3390@1|root,arCOG02258@2157|Archaea,2Y7QP@28890|Euryarchaeota,241WM@183967|Thermoplasmata	183967|Thermoplasmata	S	protein conserved in archaea	-	-	-	ko:K09746	-	-	-	-	ko00000	-	-	-	-
MMS3_k127_4062374_58	273075.Ta0387	6.014e-73	258.0	COG1599@1|root,arCOG01510@2157|Archaea,2XTGJ@28890|Euryarchaeota,241TQ@183967|Thermoplasmata	183967|Thermoplasmata	L	COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins	-	-	-	ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko03000,ko03032,ko03400	-	-	-	-
MMS3_k127_4062374_91	263820.PTO1420	1.812e-43	166.0	arCOG05407@1|root,arCOG05407@2157|Archaea,2Y3B8@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_4062374_17	273075.Ta0333	6.978e-173	550.0	COG1236@1|root,arCOG00541@2157|Archaea,2XTIU@28890|Euryarchaeota,241IR@183967|Thermoplasmata	183967|Thermoplasmata	J	Beta-Casp domain	-	-	-	ko:K07577	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,RMMBL
MMS3_k127_4062374_35	263820.PTO0942	2.381e-115	376.0	COG0005@1|root,arCOG01327@2157|Archaea,2XUJX@28890|Euryarchaeota,241MI@183967|Thermoplasmata	183967|Thermoplasmata	F	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates	mtnP	-	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
MMS3_k127_4062374_77	263820.PTO1047	5.596e-54	198.0	COG0367@1|root,arCOG00071@2157|Archaea,2XSYP@28890|Euryarchaeota,241TS@183967|Thermoplasmata	183967|Thermoplasmata	E	Asparagine synthase	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase
MMS3_k127_4062374_4	263820.PTO1161	1.366e-244	768.0	COG1855@1|root,arCOG04116@2157|Archaea,2XSZY@28890|Euryarchaeota,2420R@183967|Thermoplasmata	183967|Thermoplasmata	V	Pfam:KH_3	-	-	-	ko:K06865	-	-	-	-	ko00000	-	-	-	KH_1,T2SSE
MMS3_k127_4062374_39	273116.14324659	7.779e-106	351.0	COG0037@1|root,arCOG00042@2157|Archaea,2XTEZ@28890|Euryarchaeota,241N6@183967|Thermoplasmata	183967|Thermoplasmata	D	PP-loop family	-	-	-	-	-	-	-	-	-	-	-	-	ATP_bind_3
MMS3_k127_4062374_110	1042877.GQS_04200	1.468e-29	130.0	arCOG11292@1|root,arCOG11292@2157|Archaea,2Y3FT@28890|Euryarchaeota,2443S@183968|Thermococci	183968|Thermococci	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_4062374_28	273116.14325130	1.624e-133	443.0	COG0405@1|root,arCOG04053@2157|Archaea,2XUEX@28890|Euryarchaeota,2422W@183967|Thermoplasmata	183967|Thermoplasmata	E	Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
MMS3_k127_4062374_24	263820.PTO0683	1.139e-150	501.0	COG1123@1|root,arCOG00185@2157|Archaea,2Y7KQ@28890|Euryarchaeota,24242@183967|Thermoplasmata	183967|Thermoplasmata	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K00400,ko:K02031,ko:K02032	ko00680,ko01100,ko01120,ko02024,map00680,map01100,map01120,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
MMS3_k127_4062374_70	44251.PDUR_01435	6.465e-59	215.0	COG1173@1|root,COG1173@2|Bacteria,1TP4R@1239|Firmicutes,4HBB9@91061|Bacilli,26Q9W@186822|Paenibacillaceae	91061|Bacilli	EP	ABC transporter permease	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
MMS3_k127_4062374_52	1501230.ET33_06925	5.869e-87	298.0	COG0601@1|root,COG0601@2|Bacteria,1TP1S@1239|Firmicutes,4HBED@91061|Bacilli,26RTC@186822|Paenibacillaceae	91061|Bacilli	P	ABC transporter permease	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
MMS3_k127_4062374_81	439481.Aboo_1255	8.275e-50	198.0	COG0747@1|root,arCOG01534@2157|Archaea,2XTPJ@28890|Euryarchaeota,3F353@33867|unclassified Euryarchaeota	28890|Euryarchaeota	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
MMS3_k127_4062374_42	273116.14324434	7.783e-97	331.0	COG0477@1|root,arCOG00132@2157|Archaea,2XW9U@28890|Euryarchaeota	28890|Euryarchaeota	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like,MFS_3
MMS3_k127_4062374_33	1316927.ATKI01000046_gene678	9.103e-121	409.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1S04I@1236|Gammaproteobacteria,1YPFG@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	P	Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	E1-E2_ATPase,Hemerythrin,Hydrolase
MMS3_k127_4062374_104	797209.ZOD2009_19388	8.697e-34	139.0	COG2820@1|root,arCOG01324@2157|Archaea,2Y06F@28890|Euryarchaeota,23W2X@183963|Halobacteria	183963|Halobacteria	F	Uridine phosphorylase	-	-	2.4.2.3	ko:K00757	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01876,R02484,R08229	RC00063	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
MMS3_k127_4062374_89	273116.14324970	9.265e-44	163.0	COG1832@1|root,arCOG04227@2157|Archaea,2XXS6@28890|Euryarchaeota,242BJ@183967|Thermoplasmata	183967|Thermoplasmata	S	CoA binding domain	-	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
MMS3_k127_4062374_92	263820.PTO0894	5.151e-43	158.0	COG1594@1|root,arCOG00579@2157|Archaea,2XXU7@28890|Euryarchaeota,241WZ@183967|Thermoplasmata	183967|Thermoplasmata	K	C2C2 Zinc finger	-	-	-	ko:K03057	ko01100,map01100	-	-	-	br01611,ko00000,ko03021	-	-	-	RNA_POL_M_15KD,TFIIS_C
MMS3_k127_4062374_11	273075.Ta0515	6.624e-189	599.0	COG0541@1|root,arCOG01228@2157|Archaea,2XTWX@28890|Euryarchaeota,241J3@183967|Thermoplasmata	183967|Thermoplasmata	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	srp54	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
MMS3_k127_4062374_6	263820.PTO0896	3.915e-216	675.0	COG0644@1|root,arCOG00570@2157|Archaea,2XU3J@28890|Euryarchaeota,241M8@183967|Thermoplasmata	183967|Thermoplasmata	C	Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains	-	-	1.3.1.101,1.3.7.11	ko:K17830	ko00564,map00564	-	R10325,R10326,R10331	RC03134	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3
MMS3_k127_4062374_118	439481.Aboo_0579	5.89e-22	96.0	COG2768@1|root,arCOG02448@2157|Archaea,2Y7JX@28890|Euryarchaeota,3F2W9@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
MMS3_k127_4062374_60	263820.PTO0898	1.609e-68	239.0	COG0177@1|root,arCOG00459@2157|Archaea,2XTY1@28890|Euryarchaeota,241RZ@183967|Thermoplasmata	183967|Thermoplasmata	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
MMS3_k127_4062374_38	263820.PTO0798	1.795e-109	373.0	COG1361@1|root,arCOG02089@2157|Archaea,2Y2K3@28890|Euryarchaeota,2422R@183967|Thermoplasmata	183967|Thermoplasmata	M	extracellular matrix structural constituent	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_4062374_16	273116.14324732	3.46e-178	570.0	arCOG00144@1|root,arCOG00144@2157|Archaea,2XUGF@28890|Euryarchaeota,24238@183967|Thermoplasmata	183967|Thermoplasmata	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS3_k127_4062374_65	273057.SSO2571	1.377e-61	219.0	COG1489@1|root,arCOG04115@2157|Archaea,2XQDZ@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM Sugar fermentation stimulation protein	sfsA	-	-	ko:K06206	-	-	-	-	ko00000	-	-	-	SfsA
MMS3_k127_4062374_13	273075.Ta1189	1.913e-182	578.0	COG0156@1|root,arCOG00113@2157|Archaea,2XUFG@28890|Euryarchaeota	28890|Euryarchaeota	E	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide	bioF	-	2.3.1.29,2.3.1.47	ko:K00639,ko:K00652	ko00260,ko00780,ko01100,map00260,map00780,map01100	M00123,M00573,M00577	R00371,R03210,R10124	RC00004,RC00039,RC00394,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
MMS3_k127_4062374_47	673860.AciM339_0333	9.252e-94	317.0	COG0451@1|root,arCOG04468@2157|Archaea,2XT9R@28890|Euryarchaeota,3F346@33867|unclassified Euryarchaeota	28890|Euryarchaeota	M	3-beta hydroxysteroid dehydrogenase/isomerase family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
MMS3_k127_4062374_79	273116.14325641	1.369e-50	188.0	COG1427@1|root,arCOG00655@2157|Archaea,2Y266@28890|Euryarchaeota	28890|Euryarchaeota	S	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnA	-	4.2.1.151	ko:K11782	ko00130,ko01110,map00130,map01110	-	R10666	RC03232	ko00000,ko00001,ko01000	-	-	-	VitK2_biosynth
MMS3_k127_4062374_12	673860.AciM339_0729	4.203e-185	591.0	COG0516@1|root,arCOG00612@2157|Archaea,2XU40@28890|Euryarchaeota,3F380@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	GO:0003674,GO:0003824,GO:0003938,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
MMS3_k127_4062374_100	694431.DESACE_00410	4.104e-37	147.0	COG1573@1|root,COG1573@2|Bacteria,1MWX1@1224|Proteobacteria,42QXV@68525|delta/epsilon subdivisions,2WMXB@28221|Deltaproteobacteria,2M72R@213113|Desulfurellales	28221|Deltaproteobacteria	L	Uracil DNA glycosylase superfamily	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
MMS3_k127_4062374_64	273116.14325638	5.765e-62	223.0	COG0697@1|root,arCOG00271@2157|Archaea	2157|Archaea	EG	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
MMS3_k127_4062374_9	263820.PTO0469	9.326e-198	626.0	COG1311@1|root,arCOG04455@2157|Archaea,2XSUG@28890|Euryarchaeota,241K4@183967|Thermoplasmata	183967|Thermoplasmata	L	Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase	polB	-	2.7.7.7	ko:K02323	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	M00264	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	DNA_pol_E_B
MMS3_k127_4062374_101	263820.PTO0525	5.076e-36	139.0	arCOG05345@1|root,arCOG05345@2157|Archaea,2Y117@28890|Euryarchaeota,242B3@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_4062374_108	886293.Sinac_1029	6.91e-33	138.0	COG0631@1|root,COG0631@2|Bacteria,2IZVG@203682|Planctomycetes	203682|Planctomycetes	T	Serine/threonine phosphatases, family 2C, catalytic domain	-	-	3.1.3.16	ko:K01090,ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C_2
MMS3_k127_4062374_120	1337936.IJ00_20800	5.114e-19	103.0	COG0515@1|root,COG0515@2|Bacteria,1G1J3@1117|Cyanobacteria,1HMEK@1161|Nostocales	1117|Cyanobacteria	KLT	Serine Threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,Pkinase
MMS3_k127_4062374_134	658086.HMPREF0994_02264	0.0005955	49.0	2BC97@1|root,325U8@2|Bacteria,1URUH@1239|Firmicutes,24XUY@186801|Clostridia	186801|Clostridia	S	Double zinc ribbon	-	-	-	-	-	-	-	-	-	-	-	-	zinc_ribbon_2
MMS3_k127_4062374_56	1259795.ARJK01000002_gene154	9.36e-77	264.0	COG1116@1|root,COG1116@2|Bacteria,1TRM6@1239|Firmicutes,248CG@186801|Clostridia,42G07@68295|Thermoanaerobacterales	186801|Clostridia	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	AAA_assoc_C,ABC_tran
MMS3_k127_4062374_68	273075.Ta1070	1.931e-60	214.0	COG2095@1|root,arCOG01997@2157|Archaea,2Y3FF@28890|Euryarchaeota,2426A@183967|Thermoplasmata	183967|Thermoplasmata	U	MarC family integral membrane protein	-	-	-	ko:K05595	-	-	-	-	ko00000,ko02000	2.A.95.1	-	-	MarC
MMS3_k127_4062374_15	273116.14324743	2.407e-178	566.0	COG0451@1|root,arCOG04762@2157|Archaea,2XU8F@28890|Euryarchaeota,241XT@183967|Thermoplasmata	183967|Thermoplasmata	M	GDP-mannose 4,6 dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
MMS3_k127_4062374_76	273116.14324744	4.045e-55	202.0	COG1208@1|root,arCOG00664@2157|Archaea,2Y46V@28890|Euryarchaeota,242A9@183967|Thermoplasmata	183967|Thermoplasmata	M	Nucleotidyl transferase	-	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
MMS3_k127_4062374_21	273075.Ta1075	2.729e-162	520.0	COG0126@1|root,arCOG00496@2157|Archaea,2XSXX@28890|Euryarchaeota,241MF@183967|Thermoplasmata	183967|Thermoplasmata	F	phosphoglycerate kinase activity	pgk	-	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
MMS3_k127_4062374_121	273116.14324746	1.524e-16	85.0	COG1730@1|root,arCOG01341@2157|Archaea,2Y535@28890|Euryarchaeota,242FG@183967|Thermoplasmata	183967|Thermoplasmata	O	Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding	pfdA	-	-	ko:K04797	-	-	-	-	ko00000,ko03110	-	-	-	Prefoldin
MMS3_k127_4062374_48	263820.PTO1516	1.09e-93	317.0	COG0552@1|root,arCOG01227@2157|Archaea,2XUBI@28890|Euryarchaeota,241MV@183967|Thermoplasmata	183967|Thermoplasmata	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
MMS3_k127_4062374_98	368407.Memar_0787	1.127e-37	154.0	COG0598@1|root,arCOG02265@2157|Archaea,2XTRP@28890|Euryarchaeota,2N9K8@224756|Methanomicrobia	224756|Methanomicrobia	P	Mediates influx of magnesium ions	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
MMS3_k127_4062374_43	273116.14324729	4.659e-96	319.0	COG1709@1|root,arCOG04060@2157|Archaea,2XT58@28890|Euryarchaeota,241N9@183967|Thermoplasmata	183967|Thermoplasmata	K	Helix-turn-helix XRE-family like proteins	-	-	-	ko:K07731	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3
MMS3_k127_4062374_37	273116.14325565	4.049e-110	370.0	COG0513@1|root,arCOG00558@2157|Archaea,2XUS4@28890|Euryarchaeota,241NG@183967|Thermoplasmata	183967|Thermoplasmata	L	helicase superfamily c-terminal domain	-	-	3.6.4.13	ko:K05592	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,DbpA,Helicase_C
MMS3_k127_4062374_124	311424.DhcVS_130	2.278e-14	76.0	COG2972@1|root,COG2972@2|Bacteria,2GAV9@200795|Chloroflexi,34DF0@301297|Dehalococcoidia	301297|Dehalococcoidia	T	2TM domain	-	-	-	-	-	-	-	-	-	-	-	-	2TM
MMS3_k127_4062374_95	1343739.PAP_07760	3.273e-39	152.0	COG1670@1|root,arCOG00842@2157|Archaea,2XVC6@28890|Euryarchaeota,243ZK@183968|Thermococci	183968|Thermococci	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
MMS3_k127_4062374_50	273116.14324750	4.549e-92	306.0	COG1632@1|root,arCOG04209@2157|Archaea,2XTJJ@28890|Euryarchaeota,241PP@183967|Thermoplasmata	183967|Thermoplasmata	J	structural constituent of ribosome	rpl15e	-	-	ko:K02877	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L15e
MMS3_k127_4062374_130	273075.Ta0867	9.573e-08	56.0	COG1369@1|root,arCOG01365@2157|Archaea	2157|Archaea	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp2	GO:0000966,GO:0001682,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006464,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0030677,GO:0032991,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0046483,GO:0051604,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1902494,GO:1902555,GO:1905348,GO:1990904	3.1.26.5	ko:K03537	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03016,ko03029	-	-	-	RNase_P_Rpp14
MMS3_k127_4062374_44	263820.PTO0873	1.143e-95	328.0	COG0470@1|root,arCOG00470@2157|Archaea,2XT81@28890|Euryarchaeota,241QY@183967|Thermoplasmata	183967|Thermoplasmata	L	Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA	rfcL	-	-	ko:K04800	ko03030,map03030	-	-	-	ko00000,ko00001,ko03032	-	-	-	AAA
MMS3_k127_4062374_34	263820.PTO0985	1.424e-117	395.0	COG2244@1|root,arCOG02209@2157|Archaea,2XZR0@28890|Euryarchaeota,2422Z@183967|Thermoplasmata	183967|Thermoplasmata	S	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt
MMS3_k127_4062374_29	1051632.TPY_2966	1.616e-126	417.0	COG0427@1|root,COG0427@2|Bacteria,1TPHC@1239|Firmicutes,247V0@186801|Clostridia,3WCUB@538999|Clostridiales incertae sedis	186801|Clostridia	C	Acetyl-CoA hydrolase/transferase C-terminal domain	cat	-	-	ko:K18122	ko00650,ko01100,ko01200,map00650,map01100,map01200	-	R05336	RC00012,RC00014	ko00000,ko00001,ko01000	-	-	-	AcetylCoA_hyd_C,AcetylCoA_hydro
MMS3_k127_4062374_18	273116.14325439	1.251e-168	538.0	COG1960@1|root,arCOG04310@2157|Archaea,2XXBZ@28890|Euryarchaeota,2426V@183967|Thermoplasmata	183967|Thermoplasmata	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
MMS3_k127_4062374_51	1547437.LL06_13730	6.132e-90	313.0	COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,2TT6G@28211|Alphaproteobacteria,43GV8@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
MMS3_k127_4062374_63	395961.Cyan7425_1835	3.293e-62	228.0	COG1748@1|root,COG1748@2|Bacteria,1G37A@1117|Cyanobacteria	1117|Cyanobacteria	E	Saccharopine dehydrogenase C-terminal domain	-	-	1.5.1.7	ko:K00290	ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230	M00030,M00032	R00715	RC00217,RC01532	ko00000,ko00001,ko00002,ko01000	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP
MMS3_k127_4062374_53	273063.STK_25420	8.109e-86	295.0	COG0444@1|root,arCOG00181@2157|Archaea,2XPN5@28889|Crenarchaeota	28889|Crenarchaeota	E	TIGRFAM oligopeptide dipeptide ABC transporter, ATPase subunit	dppD	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
MMS3_k127_4062374_57	768672.Desfe_0661	1.923e-75	264.0	COG4608@1|root,arCOG00184@2157|Archaea,2XPUA@28889|Crenarchaeota	28889|Crenarchaeota	E	TIGRFAM oligopeptide dipeptide ABC transporter, ATPase subunit	-	-	-	ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
MMS3_k127_4062374_62	985053.VMUT_2190	2.394e-65	246.0	COG0747@1|root,arCOG01534@2157|Archaea,2XPZY@28889|Crenarchaeota	28889|Crenarchaeota	E	PFAM extracellular solute-binding protein, family 5	dppA	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
MMS3_k127_4062374_54	572478.Vdis_1380	1.936e-84	291.0	COG0601@1|root,arCOG00751@2157|Archaea,2XQ40@28889|Crenarchaeota	28889|Crenarchaeota	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
MMS3_k127_4062374_75	342949.PNA2_0482	3.836e-55	204.0	COG1173@1|root,arCOG00748@2157|Archaea,2XUIX@28890|Euryarchaeota,243RI@183968|Thermococci	183968|Thermococci	P	N-terminal TM domain of oligopeptide transport permease C	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
MMS3_k127_4062374_27	1123320.KB889675_gene4054	6.745e-144	471.0	COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria	201174|Actinobacteria	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.8	ko:K00130	ko00260,ko01100,map00260,map01100	M00555	R02565,R02566	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
MMS3_k127_4062374_20	263820.PTO1196	3.508e-163	518.0	COG0731@1|root,arCOG04174@2157|Archaea,2XSTF@28890|Euryarchaeota,241MW@183967|Thermoplasmata	183967|Thermoplasmata	C	Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe)	taw1	-	4.1.3.44	ko:K15449	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,Wyosine_form
MMS3_k127_4062374_2	263820.PTO1195	7.273e-251	784.0	COG0459@1|root,arCOG01257@2157|Archaea,2XUDQ@28890|Euryarchaeota,241IM@183967|Thermoplasmata	183967|Thermoplasmata	O	TCP-1/cpn60 chaperonin family	-	-	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
MMS3_k127_4062374_114	273116.14324631	8.408e-27	112.0	COG3377@1|root,arCOG04424@2157|Archaea,2Y0SF@28890|Euryarchaeota,242ES@183967|Thermoplasmata	183967|Thermoplasmata	S	Domain of unknown function (DUF1805)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1805
MMS3_k127_4062374_7	1094980.Mpsy_0403	2.112e-215	689.0	COG3808@1|root,arCOG04949@2157|Archaea,2XTDB@28890|Euryarchaeota,2N98C@224756|Methanomicrobia	224756|Methanomicrobia	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
MMS3_k127_4062374_45	263820.PTO1352	3.898e-95	321.0	COG2605@1|root,arCOG01030@2157|Archaea,2Y7A1@28890|Euryarchaeota,241YY@183967|Thermoplasmata	183967|Thermoplasmata	S	GHMP kinases C terminal	-	-	2.7.1.168	ko:K07031	ko00540,map00540	-	R09770	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
MMS3_k127_4062374_46	273116.14324471	1.445e-94	325.0	COG0477@1|root,arCOG00132@2157|Archaea,2XW9U@28890|Euryarchaeota	28890|Euryarchaeota	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like,MFS_3
MMS3_k127_4062374_40	273075.Ta1198	7.729e-98	327.0	COG0382@1|root,arCOG00477@2157|Archaea,2XW9S@28890|Euryarchaeota,24265@183967|Thermoplasmata	183967|Thermoplasmata	H	UbiA prenyltransferase family	-	-	2.5.1.39	ko:K03179	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R05000,R05615	RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
MMS3_k127_4062374_5	273075.Ta1199	1.096e-229	719.0	COG0043@1|root,arCOG01671@2157|Archaea,2XUDW@28890|Euryarchaeota,241S4@183967|Thermoplasmata	183967|Thermoplasmata	H	3-octaprenyl-4-hydroxybenzoate carboxy-lyase	-	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
MMS3_k127_4062374_0	273116.14325244	0.0	1197.0	COG0574@1|root,arCOG01111@2157|Archaea,2XU2T@28890|Euryarchaeota,241RC@183967|Thermoplasmata	183967|Thermoplasmata	G	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	-	-	2.7.9.1,2.7.9.2	ko:K01006,ko:K01007	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173,M00374	R00199,R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
MMS3_k127_4062374_66	273116.14325222	1.092e-60	218.0	COG0596@1|root,arCOG01648@2157|Archaea,2Y72P@28890|Euryarchaeota,2428V@183967|Thermoplasmata	183967|Thermoplasmata	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
MMS3_k127_4062374_94	273116.14325221	9.014e-40	157.0	COG0388@1|root,arCOG00062@2157|Archaea,2Y3PB@28890|Euryarchaeota,24280@183967|Thermoplasmata	183967|Thermoplasmata	S	Carbon-nitrogen hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
MMS3_k127_4062374_41	273116.14325220	8.268e-98	332.0	COG0452@1|root,arCOG01704@2157|Archaea,2XTZK@28890|Euryarchaeota,241PQ@183967|Thermoplasmata	183967|Thermoplasmata	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	-	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
MMS3_k127_4062374_115	1051632.TPY_0769	1.731e-26	120.0	COG3837@1|root,COG3837@2|Bacteria,1V9M6@1239|Firmicutes,24HEN@186801|Clostridia	186801|Clostridia	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
MMS3_k127_4062374_19	273075.Ta0646	1.645e-163	531.0	COG1960@1|root,arCOG04100@2157|Archaea,2XTBC@28890|Euryarchaeota,2422U@183967|Thermoplasmata	183967|Thermoplasmata	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M
MMS3_k127_4062374_72	273075.Ta0166	1.346e-58	211.0	arCOG02274@1|root,arCOG02274@2157|Archaea,2XVHG@28890|Euryarchaeota	28890|Euryarchaeota	K	DNA binding protein	-	-	-	ko:K06930	-	-	-	-	ko00000	-	-	-	HTH_10
MMS3_k127_4062374_117	273116.14324451	1.575e-23	102.0	arCOG05360@1|root,arCOG05360@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_4062374_85	273075.Ta1097	1.122e-47	179.0	COG3374@1|root,arCOG04349@2157|Archaea	2157|Archaea	S	Protein of unknown function (DUF981)	-	-	-	ko:K08980	-	-	-	-	ko00000	-	-	-	DUF981
MMS3_k127_4062374_106	1094980.Mpsy_1303	3.267e-33	133.0	COG0526@1|root,arCOG01972@2157|Archaea,2XXRJ@28890|Euryarchaeota,2N9YG@224756|Methanomicrobia	224756|Methanomicrobia	O	Thioredoxin	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
MMS3_k127_4062374_86	443143.GM18_2743	2.732e-47	184.0	COG0842@1|root,COG0842@2|Bacteria,1Q99P@1224|Proteobacteria,42M53@68525|delta/epsilon subdivisions,2WMEY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane,ABC2_membrane_3
MMS3_k127_4062374_61	386456.JQKN01000001_gene2139	1.006e-67	241.0	COG1131@1|root,arCOG00194@2157|Archaea,2XT1I@28890|Euryarchaeota	28890|Euryarchaeota	E	ABC-type multidrug transport system, ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
MMS3_k127_4062374_90	273075.Ta0194m	1.431e-43	166.0	COG0596@1|root,arCOG01648@2157|Archaea,2Y4RP@28890|Euryarchaeota,242DY@183967|Thermoplasmata	183967|Thermoplasmata	S	Phospholipase/Carboxylesterase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
MMS3_k127_4062374_112	525904.Tter_1476	3.091e-27	120.0	COG1011@1|root,COG1011@2|Bacteria	2|Bacteria	S	phosphatase activity	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
MMS3_k127_4062374_131	1429046.RR21198_5160	6.756e-06	54.0	COG1846@1|root,COG1846@2|Bacteria,2IBDP@201174|Actinobacteria,4G14N@85025|Nocardiaceae	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
MMS3_k127_4062374_22	263820.PTO0162	7.483e-160	517.0	arCOG00144@1|root,arCOG00144@2157|Archaea,2XUGF@28890|Euryarchaeota,24238@183967|Thermoplasmata	28890|Euryarchaeota	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS3_k127_4062374_55	263820.PTO1014	2.157e-80	281.0	COG0535@1|root,arCOG00938@2157|Archaea,2Y8D0@28890|Euryarchaeota,2422F@183967|Thermoplasmata	183967|Thermoplasmata	S	Iron-sulfur cluster-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM,SPASM
MMS3_k127_4062374_111	1380390.JIAT01000012_gene3101	2.112e-29	127.0	2AWU5@1|root,31NRA@2|Bacteria,2HR9Y@201174|Actinobacteria,4CT6Q@84995|Rubrobacteria	84995|Rubrobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_4062374_102	1206101.AZXC01000006_gene4116	1.189e-35	141.0	COG1670@1|root,COG1670@2|Bacteria,2IE9P@201174|Actinobacteria	201174|Actinobacteria	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
MMS3_k127_4062374_107	985053.VMUT_1872	5.254e-33	136.0	COG3371@1|root,arCOG02008@2157|Archaea,2XRYZ@28889|Crenarchaeota	28889|Crenarchaeota	S	Protein of unknown function (DUF998)	-	-	-	-	-	-	-	-	-	-	-	-	DUF998
MMS3_k127_4062374_67	264462.Bd3186	1.898e-60	217.0	COG0500@1|root,COG0500@2|Bacteria,1QY2M@1224|Proteobacteria	1224|Proteobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
MMS3_k127_4062374_113	1459636.NTE_02270	5.344e-27	113.0	COG0640@1|root,arCOG01681@2157|Archaea	2157|Archaea	K	regulatory protein, arsR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
MMS3_k127_4062374_132	903814.ELI_1208	3.641e-05	51.0	COG0477@1|root,COG0477@2|Bacteria,1UHRM@1239|Firmicutes,24AEF@186801|Clostridia,25UZR@186806|Eubacteriaceae	186801|Clostridia	EGP	Transmembrane secretion effector	-	-	-	ko:K08217	-	-	-	-	br01600,ko00000,ko01504,ko02000	2.A.1.21.1,2.A.1.21.22	-	-	MFS_1,MFS_3
MMS3_k127_4062374_133	1353528.DT23_17705	0.0005288	51.0	COG1522@1|root,COG1522@2|Bacteria,1MX7R@1224|Proteobacteria,2U7B2@28211|Alphaproteobacteria,2XNCE@285107|Thioclava	28211|Alphaproteobacteria	K	transcriptional	putR	-	-	ko:K03719	-	-	-	-	ko00000,ko03000,ko03036	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
MMS3_k127_4062374_93	589865.DaAHT2_1404	2.378e-40	161.0	COG3177@1|root,COG3177@2|Bacteria,1MX0V@1224|Proteobacteria,42RKK@68525|delta/epsilon subdivisions,2WNV3@28221|Deltaproteobacteria,2MK5P@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Fic/DOC family	-	-	-	-	-	-	-	-	-	-	-	-	Fic
MMS3_k127_546553_91	263820.PTO1158	7.193e-18	83.0	arCOG05387@1|root,arCOG05387@2157|Archaea,2Y1EF@28890|Euryarchaeota,242GU@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_546553_100	273116.14324482	6.183e-07	58.0	arCOG05382@1|root,arCOG05382@2157|Archaea,2Y5Z0@28890|Euryarchaeota,242HQ@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_546553_7	386456.JQKN01000002_gene2482	3.338e-182	592.0	COG1331@1|root,arCOG02007@2157|Archaea,2XU5Q@28890|Euryarchaeota	28890|Euryarchaeota	O	COG1331 Highly conserved protein containing a thioredoxin domain	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	GlcNAc_2-epim,Thioredox_DsbH
MMS3_k127_546553_68	273075.Ta0823	2.667e-40	156.0	COG0406@1|root,arCOG01991@2157|Archaea,2Y23H@28890|Euryarchaeota,2428S@183967|Thermoplasmata	183967|Thermoplasmata	G	Phosphoglycerate mutase family	-	-	5.4.2.12	ko:K15634	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
MMS3_k127_546553_71	273116.14325051	5.229e-39	150.0	COG1956@1|root,arCOG05374@2157|Archaea,2Y497@28890|Euryarchaeota,242AW@183967|Thermoplasmata	183967|Thermoplasmata	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	1.8.4.14	ko:K08968	ko00270,map00270	-	R02025	RC00639	ko00000,ko00001,ko01000	-	-	-	GAF_2
MMS3_k127_546553_85	273075.Ta0505	2.787e-21	106.0	arCOG03290@1|root,arCOG03290@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_546553_102	273075.Ta0503a	1.386e-05	53.0	arCOG07381@1|root,arCOG07381@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_546553_28	273075.Ta0503	3.969e-105	363.0	COG0531@1|root,arCOG00009@2157|Archaea	2157|Archaea	E	amino acid	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease,AA_permease_2
MMS3_k127_546553_10	273075.Ta1147	8.494e-143	466.0	COG0215@1|root,arCOG00486@2157|Archaea,2XTRY@28890|Euryarchaeota,241IS@183967|Thermoplasmata	183967|Thermoplasmata	J	cysteine-tRNA ligase activity	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1e
MMS3_k127_546553_76	309799.DICTH_1851	2.235e-33	135.0	COG1335@1|root,COG1335@2|Bacteria	2|Bacteria	Q	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	-	-	3.5.1.19	ko:K08281	ko00760,ko01100,map00760,map01100	-	R01268	RC00100	ko00000,ko00001,ko01000	-	-	-	Isochorismatase,MerR_1
MMS3_k127_546553_11	273116.14325505	4.88e-140	454.0	COG1488@1|root,arCOG01481@2157|Archaea,2XU8Y@28890|Euryarchaeota,241KX@183967|Thermoplasmata	183967|Thermoplasmata	H	Quinolinate phosphoribosyl transferase, C-terminal domain	-	-	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	-	QRPTase_C
MMS3_k127_546553_60	273116.14325187	2.014e-47	177.0	COG0637@1|root,arCOG02293@2157|Archaea,2Y6Y6@28890|Euryarchaeota,241WQ@183967|Thermoplasmata	183967|Thermoplasmata	S	HAD-hyrolase-like	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
MMS3_k127_546553_21	273116.14325189	5.946e-113	373.0	COG1064@1|root,arCOG01455@2157|Archaea,2XT0X@28890|Euryarchaeota,241ZZ@183967|Thermoplasmata	183967|Thermoplasmata	C	Zinc-binding dehydrogenase	-	-	1.3.1.84	ko:K15020	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00375	R00919	RC00095	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
MMS3_k127_546553_70	273075.Ta1007	2.99e-39	155.0	arCOG01916@1|root,arCOG01916@2157|Archaea,2Y4Q0@28890|Euryarchaeota,242BX@183967|Thermoplasmata	183967|Thermoplasmata	S	zinc-ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	zinc_ribbon_2
MMS3_k127_546553_39	273116.14324884	5.772e-75	261.0	COG0329@1|root,arCOG04172@2157|Archaea,2Y2YX@28890|Euryarchaeota,2425H@183967|Thermoplasmata	183967|Thermoplasmata	E	Dihydrodipicolinate synthetase family	-	-	4.1.2.55	ko:K11395	ko00030,ko00052,ko01100,ko01120,ko01200,map00030,map00052,map01100,map01120,map01200	M00309,M00633	R01064,R05605,R08570,R10616	RC00307,RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
MMS3_k127_546553_46	936375.HMPREF1152_0766	4.586e-61	230.0	COG2189@1|root,COG2189@2|Bacteria,1TR8A@1239|Firmicutes,249A1@186801|Clostridia,3WDFF@538999|Clostridiales incertae sedis	186801|Clostridia	L	DNA methylase	-	-	2.1.1.72	ko:K00571,ko:K07316	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
MMS3_k127_546553_24	273075.Ta0662m	3.933e-109	369.0	COG1574@1|root,arCOG00691@2157|Archaea,2XUUZ@28890|Euryarchaeota	28890|Euryarchaeota	S	metal-dependent hydrolase with the TIM-barrel fold	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
MMS3_k127_546553_6	330779.Saci_2208	7.372e-183	591.0	COG1250@1|root,arCOG00249@2157|Archaea,2XPQ7@28889|Crenarchaeota	28889|Crenarchaeota	I	3-hydroxyacyl-CoA dehydrogenase	-	-	1.1.1.35,4.2.1.17	ko:K15016	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00374,M00375	R01975,R03026	RC00117,RC00831	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
MMS3_k127_546553_57	1460634.JCM19037_1835	1.739e-50	195.0	COG1960@1|root,COG1960@2|Bacteria,1TP57@1239|Firmicutes,4HA2A@91061|Bacilli	91061|Bacilli	I	acyl-CoA dehydrogenase	mmgC	-	-	ko:K18244	-	-	-	-	ko00000,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
MMS3_k127_546553_93	273075.Ta0362	1.344e-16	91.0	arCOG07369@1|root,arCOG07369@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_546553_29	1229909.NSED_00010	2.974e-101	347.0	COG0423@1|root,arCOG00405@2157|Archaea,41S8S@651137|Thaumarchaeota	651137|Thaumarchaeota	J	synthetase (class II)	-	-	6.1.1.14	ko:K01880	ko00970,map00970	M00359,M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	HGTP_anticodon,tRNA-synt_2b
MMS3_k127_546553_17	673860.AciM339_0102	1.436e-131	430.0	COG1228@1|root,arCOG00696@2157|Archaea,2XVAU@28890|Euryarchaeota,3F2Z2@33867|unclassified Euryarchaeota	28890|Euryarchaeota	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
MMS3_k127_546553_49	1121875.KB907547_gene3294	3.204e-58	220.0	COG0578@1|root,COG0578@2|Bacteria,4PKIZ@976|Bacteroidetes	976|Bacteroidetes	C	Glycerol-3-phosphate dehydrogenase	glpD	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,DAO_C
MMS3_k127_546553_105	273116.14324449	0.0006313	48.0	arCOG03769@1|root,arCOG03769@2157|Archaea	2157|Archaea	M	glucosylceramidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_546553_34	263820.PTO1372	1.655e-85	289.0	COG0819@1|root,arCOG01128@2157|Archaea	2157|Archaea	K	transcription activator	-	-	1.3.3.11	ko:K06137,ko:K20896	ko00730,ko01100,map00730,map01100	-	R09993,R11313	RC00197,RC02832	ko00000,ko00001,ko01000	-	-	-	Haem_oxygenas_2,TENA_THI-4
MMS3_k127_546553_26	273063.STK_05870	1.517e-108	363.0	COG0372@1|root,arCOG04237@2157|Archaea,2XPMK@28889|Crenarchaeota	28889|Crenarchaeota	C	TIGRFAM 2-methylcitrate synthase citrate synthase II	gltA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
MMS3_k127_546553_40	273057.SSO2979	6.759e-75	262.0	arCOG05356@1|root,arCOG05356@2157|Archaea	2157|Archaea	S	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
MMS3_k127_546553_84	263820.PTO1015	1.064e-24	109.0	COG1814@1|root,arCOG01091@2157|Archaea,2Y4VZ@28890|Euryarchaeota,242DZ@183967|Thermoplasmata	183967|Thermoplasmata	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_546553_86	273116.14324607	3.029e-21	96.0	COG1888@1|root,arCOG04140@2157|Archaea,2Y6FP@28890|Euryarchaeota,242EC@183967|Thermoplasmata	183967|Thermoplasmata	S	Uncharacterized ArCR, COG1888	-	-	-	ko:K09732	-	-	-	-	ko00000	-	-	-	DUF211
MMS3_k127_546553_59	397948.Cmaq_0589	2.728e-49	187.0	COG5424@1|root,arCOG06031@2157|Archaea,2XRWB@28889|Crenarchaeota	28889|Crenarchaeota	H	Iron-containing redox enzyme	-	-	1.3.3.11	ko:K06137	-	-	-	-	ko00000,ko01000	-	-	-	TENA_THI-4,zf-C2H2_9
MMS3_k127_546553_97	273116.14324735	2.096e-11	68.0	arCOG05391@1|root,arCOG05391@2157|Archaea,2Y53B@28890|Euryarchaeota,242H4@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_546553_41	273075.Ta1064	1.167e-73	254.0	COG1339@1|root,arCOG01904@2157|Archaea,2XTFW@28890|Euryarchaeota,241PC@183967|Thermoplasmata	183967|Thermoplasmata	F	Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN)	ribK	-	2.7.1.161	ko:K07732	ko00740,ko01100,map00740,map01100	-	R08574	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	CTP-dep_RFKase,HTH_Crp_2
MMS3_k127_546553_94	263820.PTO0970	1.506e-15	81.0	COG1412@1|root,arCOG04312@2157|Archaea,2Y0D4@28890|Euryarchaeota,242GQ@183967|Thermoplasmata	183967|Thermoplasmata	V	Large family of predicted nucleotide-binding domains	-	-	-	ko:K07158	-	-	-	-	ko00000	-	-	-	-
MMS3_k127_546553_42	273116.14324870	4.192e-67	234.0	COG1601@1|root,arCOG01640@2157|Archaea,2XTVZ@28890|Euryarchaeota,241R9@183967|Thermoplasmata	183967|Thermoplasmata	J	eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA	eif2b	-	-	ko:K03238	ko03013,map03013	-	-	-	ko00000,ko00001,ko01009,ko03012	-	-	-	TRAM,eIF-5_eIF-2B
MMS3_k127_546553_96	263820.PTO0972	1.051e-14	79.0	arCOG06971@1|root,arCOG06971@2157|Archaea,2Y24Q@28890|Euryarchaeota,242H0@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_546553_99	273116.14324872	1.928e-08	64.0	COG0206@1|root,arCOG02201@2157|Archaea	2157|Archaea	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	-	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	Tubulin
MMS3_k127_546553_50	273116.14324847	8.865e-58	204.0	COG1781@1|root,arCOG04229@2157|Archaea,2XWP4@28890|Euryarchaeota,241SX@183967|Thermoplasmata	183967|Thermoplasmata	F	Involved in allosteric regulation of aspartate carbamoyltransferase	pyrI	-	-	ko:K00610	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002	-	-	-	PyrI,PyrI_C
MMS3_k127_546553_19	273116.14324846	6.006e-118	388.0	COG0540@1|root,arCOG00911@2157|Archaea,2XSZ7@28890|Euryarchaeota,241J0@183967|Thermoplasmata	183967|Thermoplasmata	F	aspartate carbamoyltransferase activity	pyrB	-	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
MMS3_k127_546553_8	273075.Ta0406m	3.518e-160	515.0	COG1257@1|root,arCOG04260@2157|Archaea,2XTV9@28890|Euryarchaeota,241X1@183967|Thermoplasmata	183967|Thermoplasmata	I	Hydroxymethylglutaryl-coenzyme A reductase	-	-	1.1.1.34,1.1.1.88	ko:K00021,ko:K00054	ko00900,ko01100,ko01110,ko01130,ko04152,ko04976,map00900,map01100,map01110,map01130,map04152,map04976	M00095	R02081,R02082	RC00004,RC00644	ko00000,ko00001,ko00002,ko01000	-	-	-	HMG-CoA_red
MMS3_k127_546553_75	263820.PTO1142	1.306e-34	141.0	COG0457@1|root,arCOG03045@2157|Archaea,2Y3R1@28890|Euryarchaeota,2429D@183967|Thermoplasmata	183967|Thermoplasmata	S	tetratricopeptide	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_546553_74	273075.Ta0459	8.806e-35	138.0	COG3612@1|root,arCOG04418@2157|Archaea,2Y7B7@28890|Euryarchaeota,242A8@183967|Thermoplasmata	183967|Thermoplasmata	S	Uncharacterized protein conserved in archaea (DUF2240)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2240
MMS3_k127_546553_27	273116.14325318	1.612e-105	351.0	COG2896@1|root,arCOG00930@2157|Archaea,2XT7P@28890|Euryarchaeota,24220@183967|Thermoplasmata	183967|Thermoplasmata	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Mob_synth_C,Radical_SAM
MMS3_k127_546553_53	273116.14325188	8.39e-53	194.0	COG0476@1|root,arCOG01676@2157|Archaea,2XTYV@28890|Euryarchaeota,24282@183967|Thermoplasmata	183967|Thermoplasmata	H	ThiF family	-	-	2.7.7.80	ko:K21029,ko:K22132	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000,ko03016	-	-	-	ThiF
MMS3_k127_546553_73	263820.PTO1060	2.466e-36	143.0	COG0521@1|root,arCOG00214@2157|Archaea,2XWJF@28890|Euryarchaeota,242AQ@183967|Thermoplasmata	183967|Thermoplasmata	H	Probable molybdopterin binding domain	-	-	2.7.7.75	ko:K03638	ko00790,ko01100,map00790,map01100	-	R09726	RC00002	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth
MMS3_k127_546553_65	273116.14324976	1.969e-42	160.0	COG0315@1|root,arCOG01530@2157|Archaea,2XWHQ@28890|Euryarchaeota,242AU@183967|Thermoplasmata	183967|Thermoplasmata	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
MMS3_k127_546553_80	744980.TRICHSKD4_1457	3.768e-29	124.0	COG2068@1|root,COG2068@2|Bacteria,1MW0X@1224|Proteobacteria,2TR5D@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Molybdopterin	MA20_09420	-	2.7.7.76	ko:K07141	ko00790,map00790	-	R11582	-	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,NTP_transf_3
MMS3_k127_546553_77	263820.PTO1508	3.529e-31	133.0	COG1975@1|root,arCOG01929@2157|Archaea	2157|Archaea	O	COG1975 Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI,YHS
MMS3_k127_546553_55	479434.Sthe_2778	1.933e-51	194.0	COG1319@1|root,COG1319@2|Bacteria,2G84Z@200795|Chloroflexi,27Z3G@189775|Thermomicrobia	189775|Thermomicrobia	C	CO dehydrogenase flavoprotein C-terminal domain	-	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
MMS3_k127_546553_52	867903.ThesuDRAFT_01357	3.245e-55	197.0	COG2080@1|root,COG2080@2|Bacteria,1V6HE@1239|Firmicutes,24J9B@186801|Clostridia	186801|Clostridia	C	aerobic-type carbon monoxide dehydrogenase, small subunit CoxS	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
MMS3_k127_546553_5	263820.PTO1121	1.488e-196	633.0	COG1529@1|root,arCOG01167@2157|Archaea,2XSZN@28890|Euryarchaeota	28890|Euryarchaeota	C	COG1529 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL CutL homologs	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
MMS3_k127_546553_82	224324.aq_2181	6.38e-28	118.0	COG0314@1|root,COG0314@2|Bacteria,2G551@200783|Aquificae	200783|Aquificae	H	molybdopterin	moaE	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016740,GO:0016782,GO:0016783,GO:0018130,GO:0019538,GO:0019637,GO:0019693,GO:0030366,GO:0032324,GO:0034641,GO:0042278,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657	2.8.1.12	ko:K03635	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoaE
MMS3_k127_546553_45	273075.Ta1368m	1.619e-62	218.0	COG1225@1|root,arCOG00310@2157|Archaea,2XXB2@28890|Euryarchaeota,2427J@183967|Thermoplasmata	183967|Thermoplasmata	O	AhpC/TSA family	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
MMS3_k127_546553_48	273116.14325268	3.346e-59	212.0	COG2102@1|root,arCOG00035@2157|Archaea,2XTNJ@28890|Euryarchaeota,241U3@183967|Thermoplasmata	183967|Thermoplasmata	S	Diphthamide synthase	-	-	6.3.1.14	ko:K06927	-	-	R03613	RC00358	ko00000,ko01000,ko03012	-	-	-	Diphthami_syn_2
MMS3_k127_546553_22	673860.AciM339_0294	3.182e-111	369.0	COG2108@1|root,arCOG00932@2157|Archaea,2XU78@28890|Euryarchaeota,3F2FA@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	4Fe-4S single cluster domain	-	-	-	ko:K07129	-	-	-	-	ko00000	-	-	-	Fer4_14,Radical_SAM
MMS3_k127_546553_69	263820.PTO0817	1.336e-39	154.0	arCOG03379@1|root,arCOG03379@2157|Archaea,2XZH1@28890|Euryarchaeota,241W9@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_546553_13	273116.14325266	5.678e-138	452.0	COG0015@1|root,arCOG01747@2157|Archaea,2XUQ5@28890|Euryarchaeota,241KV@183967|Thermoplasmata	183967|Thermoplasmata	F	Adenylosuccinate lyase C-terminus	-	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
MMS3_k127_546553_95	273075.Ta0167	7.353e-15	90.0	arCOG03675@1|root,arCOG03675@2157|Archaea	2157|Archaea	S	Thermopsin	-	-	3.4.23.42	ko:K01385	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Thermopsin
MMS3_k127_546553_32	273116.14325200	9.659e-93	319.0	COG1215@1|root,arCOG01389@2157|Archaea,2Y7A9@28890|Euryarchaeota,2420I@183967|Thermoplasmata	183967|Thermoplasmata	M	Glycosyl transferase family 21	-	-	-	ko:K00786	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_tranf_2_3
MMS3_k127_546553_30	273075.Ta0508m	9.317e-101	339.0	COG0206@1|root,arCOG02201@2157|Archaea,2XTMW@28890|Euryarchaeota	28890|Euryarchaeota	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ1	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
MMS3_k127_546553_23	273075.Ta0618	1.656e-110	363.0	COG3959@1|root,arCOG01053@2157|Archaea,2XT88@28890|Euryarchaeota,241MN@183967|Thermoplasmata	183967|Thermoplasmata	G	1-deoxy-D-xylulose-5-phosphate synthase	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
MMS3_k127_546553_14	273075.Ta0617	1.661e-134	435.0	COG3958@1|root,arCOG01051@2157|Archaea,2Y86K@28890|Euryarchaeota,241IF@183967|Thermoplasmata	183967|Thermoplasmata	G	Transketolase, pyrimidine binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
MMS3_k127_546553_47	1304875.JAFZ01000001_gene1332	4.984e-60	214.0	COG0176@1|root,COG0176@2|Bacteria,3TA7M@508458|Synergistetes	508458|Synergistetes	H	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
MMS3_k127_546553_1	263820.PTO0687	2.004e-315	975.0	COG1782@1|root,arCOG00543@2157|Archaea,2XTIM@28890|Euryarchaeota,241KZ@183967|Thermoplasmata	183967|Thermoplasmata	S	KH domain	-	-	-	ko:K07041	-	-	-	-	ko00000	-	-	-	Beta-Casp,KH_7,Lactamase_B,Lactamase_B_6,RMMBL
MMS3_k127_546553_35	273116.14324878	5.916e-84	283.0	COG0638@1|root,arCOG00970@2157|Archaea,2XUIZ@28890|Euryarchaeota,241Q3@183967|Thermoplasmata	183967|Thermoplasmata	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	psmB	GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0019538,GO:0019774,GO:0030163,GO:0032991,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0070003,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03433	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
MMS3_k127_546553_67	273075.Ta0611	2.37e-40	153.0	COG0517@1|root,arCOG00606@2157|Archaea,2Y0BC@28890|Euryarchaeota,242A4@183967|Thermoplasmata	183967|Thermoplasmata	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
MMS3_k127_546553_78	273116.14324875	9.417e-31	130.0	COG0417@1|root,arCOG00328@2157|Archaea	273116.14324875|-	L	DNA polymerase	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_546553_79	263820.PTO1275	2.956e-30	126.0	arCOG05401@1|root,arCOG05401@2157|Archaea,2Y42P@28890|Euryarchaeota,242AN@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_546553_64	273075.Ta0548m	7.72e-43	160.0	arCOG05362@1|root,arCOG05362@2157|Archaea,2Y5IA@28890|Euryarchaeota,242EZ@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_546553_25	273075.Ta0309	4.598e-109	361.0	COG0152@1|root,arCOG04421@2157|Archaea,2XTW4@28890|Euryarchaeota,241JR@183967|Thermoplasmata	183967|Thermoplasmata	F	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity	purC	-	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
MMS3_k127_546553_51	263820.PTO1068	1.118e-57	216.0	COG0500@1|root,arCOG05015@2157|Archaea,2XX0Y@28890|Euryarchaeota,2427E@183967|Thermoplasmata	183967|Thermoplasmata	Q	RNA cap guanine-N2 methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_546553_37	273116.14324789	7.096e-77	262.0	COG0807@1|root,arCOG01321@2157|Archaea,2XVGI@28890|Euryarchaeota,24234@183967|Thermoplasmata	183967|Thermoplasmata	H	Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate	ribA	-	3.5.4.25	ko:K01497	ko00740,ko00790,ko01100,ko01110,ko02024,map00740,map00790,map01100,map01110,map02024	M00125	R00425	RC00293,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydro2
MMS3_k127_546553_12	263820.PTO1070	2.186e-139	451.0	COG1063@1|root,arCOG01459@2157|Archaea,2XT9P@28890|Euryarchaeota,24209@183967|Thermoplasmata	183967|Thermoplasmata	E	Catalyzes the NAD(P)( )-dependent oxidation of D-glucose to D-gluconate via gluconolactone. Can utilize both NAD( ) and NADP( ) as electron acceptor. Is involved in the degradation of glucose through a non-phosphorylative variant of the Entner- Doudoroff pathway	gdh	GO:0000166,GO:0003674,GO:0003824,GO:0004344,GO:0005488,GO:0005534,GO:0005536,GO:0005975,GO:0005996,GO:0006006,GO:0006007,GO:0006012,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016043,GO:0016052,GO:0016491,GO:0016614,GO:0016616,GO:0019318,GO:0019320,GO:0019388,GO:0019595,GO:0022607,GO:0030246,GO:0033498,GO:0036094,GO:0043167,GO:0043168,GO:0043933,GO:0044085,GO:0044238,GO:0044281,GO:0044282,GO:0046365,GO:0046430,GO:0047910,GO:0047936,GO:0048029,GO:0048037,GO:0050661,GO:0050662,GO:0051259,GO:0051262,GO:0051287,GO:0055114,GO:0065003,GO:0070401,GO:0070403,GO:0071704,GO:0071840,GO:0097159,GO:1901265,GO:1901363,GO:1901575	1.1.1.360	ko:K18124	ko00030,ko00052,ko01100,ko01110,ko01130,ko01200,map00030,map00052,map01100,map01110,map01130,map01200	-	R01096,R07147	RC00066	ko00000,ko00001,ko01000	-	-	-	ADH_N,Glu_dehyd_C
MMS3_k127_546553_36	273075.Ta0898	1.916e-82	282.0	COG2759@1|root,arCOG04538@2157|Archaea,2XTE0@28890|Euryarchaeota,241PA@183967|Thermoplasmata	183967|Thermoplasmata	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	-	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
MMS3_k127_546553_44	273075.Ta0899	8.507e-67	235.0	COG0171@1|root,arCOG00069@2157|Archaea,2XT7M@28890|Euryarchaeota,241S8@183967|Thermoplasmata	183967|Thermoplasmata	F	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source	nadE	-	6.3.1.5	ko:K01916	ko00760,ko01100,map00760,map01100	M00115	R00189	RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	NAD_synthase
MMS3_k127_546553_16	263820.PTO0987	5.203e-133	436.0	COG0025@1|root,arCOG01961@2157|Archaea,2XT52@28890|Euryarchaeota,24223@183967|Thermoplasmata	183967|Thermoplasmata	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
MMS3_k127_546553_15	673860.AciM339_0009	2.12e-134	445.0	COG4962@1|root,arCOG01817@2157|Archaea,2XT4E@28890|Euryarchaeota,3F2TI@33867|unclassified Euryarchaeota	28890|Euryarchaeota	N	Type II/IV secretion system protein	-	-	-	ko:K07332	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
MMS3_k127_546553_72	439481.Aboo_0008	1.042e-38	155.0	COG2064@1|root,arCOG01808@2157|Archaea,2XT4Q@28890|Euryarchaeota,3F37F@33867|unclassified Euryarchaeota	28890|Euryarchaeota	N	Type II secretion system	-	-	-	ko:K07333	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSF
MMS3_k127_546553_61	439481.Aboo_0007	1.825e-46	190.0	COG2064@1|root,arCOG01808@2157|Archaea,2XT4Q@28890|Euryarchaeota,3F36C@33867|unclassified Euryarchaeota	28890|Euryarchaeota	N	Type II secretion system	-	-	-	ko:K07333	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSF
MMS3_k127_546553_9	439481.Aboo_0006	4.994e-143	469.0	COG4962@1|root,arCOG01817@2157|Archaea,2XT4E@28890|Euryarchaeota,3F381@33867|unclassified Euryarchaeota	28890|Euryarchaeota	N	Type II/IV secretion system protein	-	-	-	ko:K07332	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
MMS3_k127_546553_90	565033.GACE_0502	4.202e-18	95.0	COG1216@1|root,arCOG01383@2157|Archaea,2Y668@28890|Euryarchaeota,247A7@183980|Archaeoglobi	183980|Archaeoglobi	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
MMS3_k127_546553_104	929506.CbC4_0593	5.921e-05	54.0	COG4106@1|root,COG4106@2|Bacteria,1V21K@1239|Firmicutes,24G2Z@186801|Clostridia,36Q3T@31979|Clostridiaceae	186801|Clostridia	H	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway	bioC	-	2.1.1.197	ko:K02169	ko00780,ko01100,map00780,map01100	M00572	R09543	RC00003,RC00460	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_31
MMS3_k127_546553_103	1307436.PBF_17404	2.017e-05	56.0	COG0500@1|root,COG2226@2|Bacteria,1U9IT@1239|Firmicutes,4HDV5@91061|Bacilli,1ZC30@1386|Bacillus	91061|Bacilli	Q	Methionine biosynthesis protein MetW	rebM	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
MMS3_k127_546553_98	485918.Cpin_3705	3.686e-11	74.0	COG1215@1|root,COG1215@2|Bacteria,4NEG0@976|Bacteroidetes,1INP1@117747|Sphingobacteriia	976|Bacteroidetes	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glycos_transf_2
MMS3_k127_546553_101	1382356.JQMP01000003_gene1338	1.109e-05	58.0	COG5650@1|root,COG5650@2|Bacteria,2GB8F@200795|Chloroflexi,27Y1V@189775|Thermomicrobia	189775|Thermomicrobia	S	phosphatidylinositol metabolic process	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_546553_92	273063.STK_26120	1.93e-17	93.0	COG0454@1|root,arCOG00826@2157|Archaea	2157|Archaea	K	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases	-	-	-	ko:K06976	-	-	-	-	ko00000	-	-	-	Acetyltransf_1,Acetyltransf_9
MMS3_k127_546553_4	263820.PTO1261	2.59e-206	653.0	COG1012@1|root,arCOG01252@2157|Archaea,2XVV5@28890|Euryarchaeota,241TP@183967|Thermoplasmata	183967|Thermoplasmata	C	Aldehyde dehydrogenase family	-	-	1.2.1.88	ko:K00294	ko00250,ko00330,ko01100,map00250,map00330,map01100	-	R00245,R00707,R00708,R04444,R04445,R05051	RC00080,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000	-	-	-	Aldedh
MMS3_k127_546553_58	263820.PTO1260	4.617e-50	186.0	COG0321@1|root,arCOG01942@2157|Archaea	2157|Archaea	H	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate	lipB	GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0016740,GO:0016746,GO:0016747,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0033819,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564	2.3.1.181	ko:K03801	ko00785,ko01100,map00785,map01100	-	R07766,R07769	RC00039,RC00992,RC02867	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
MMS3_k127_546553_66	263820.PTO1287	1.329e-40	159.0	COG1497@1|root,arCOG04399@2157|Archaea,2XU16@28890|Euryarchaeota,24299@183967|Thermoplasmata	183967|Thermoplasmata	K	Regulatory protein Crp	-	-	-	ko:K07730	-	-	-	-	ko00000,ko03000	-	-	-	-
MMS3_k127_546553_62	263820.PTO1286	1.905e-43	162.0	COG1586@1|root,arCOG00279@2157|Archaea,2XXWH@28890|Euryarchaeota,242A3@183967|Thermoplasmata	183967|Thermoplasmata	F	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine	speH	-	4.1.1.50	ko:K01611	ko00270,ko00330,ko01100,map00270,map00330,map01100	M00034,M00133	R00178	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	AdoMet_dc
MMS3_k127_546553_83	263820.PTO1285	8.572e-28	125.0	COG0530@1|root,arCOG02881@2157|Archaea,2Y7DS@28890|Euryarchaeota,242GN@183967|Thermoplasmata	183967|Thermoplasmata	P	Sodium/calcium exchanger protein	-	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
MMS3_k127_546553_3	263820.PTO1284	3.742e-212	674.0	COG0532@1|root,arCOG01560@2157|Archaea,2XU09@28890|Euryarchaeota,241KA@183967|Thermoplasmata	183967|Thermoplasmata	J	Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2	infB	-	-	ko:K03243	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D4,IF-2
MMS3_k127_546553_54	273116.14324665	3.015e-52	189.0	COG0105@1|root,arCOG04313@2157|Archaea,2XWSK@28890|Euryarchaeota,241SJ@183967|Thermoplasmata	183967|Thermoplasmata	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	-	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
MMS3_k127_546553_87	263820.PTO1282	1.155e-20	92.0	COG2075@1|root,arCOG01950@2157|Archaea,2Y00Q@28890|Euryarchaeota,241X3@183967|Thermoplasmata	183967|Thermoplasmata	J	Binds to the 23S rRNA	rpl24e	-	-	ko:K02896	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L24e
MMS3_k127_546553_81	263820.PTO1281	1.307e-28	115.0	COG2053@1|root,arCOG04314@2157|Archaea,2XYMV@28890|Euryarchaeota,241VA@183967|Thermoplasmata	183967|Thermoplasmata	J	Belongs to the eukaryotic ribosomal protein eS28 family	rps28e	-	-	ko:K02979	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S28e
MMS3_k127_546553_56	273075.Ta1116	2.389e-51	184.0	COG1358@1|root,arCOG01751@2157|Archaea,2XX4C@28890|Euryarchaeota,241TC@183967|Thermoplasmata	183967|Thermoplasmata	J	Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H ACA, box C D and box C' D' sRNAs	rpl7ae	-	-	ko:K02936	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03009,ko03011	-	-	-	Ribosomal_L7Ae
MMS3_k127_546553_31	273116.14325490	2.607e-94	317.0	COG0329@1|root,arCOG04172@2157|Archaea,2XSZX@28890|Euryarchaeota,241UJ@183967|Thermoplasmata	183967|Thermoplasmata	E	lyase activity	-	GO:0003674,GO:0003824,GO:0005975,GO:0005996,GO:0006006,GO:0006007,GO:0008150,GO:0008152,GO:0008674,GO:0008675,GO:0009056,GO:0016052,GO:0016829,GO:0016830,GO:0016832,GO:0019318,GO:0019320,GO:0044238,GO:0044281,GO:0044282,GO:0046365,GO:0071704,GO:1901575	4.1.2.51,4.3.3.7	ko:K01714,ko:K18127	ko00030,ko00052,ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00052,map00261,map00300,map01100,map01110,map01120,map01130,map01200,map01230	M00016,M00309,M00525,M00526,M00527	R08570,R10147,R10616	RC00307,RC00435,RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
MMS3_k127_546553_63	273116.14325496	2.565e-43	165.0	arCOG06972@1|root,arCOG06972@2157|Archaea,2Y4W6@28890|Euryarchaeota,242C4@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_546553_33	930945.SiRe_0569	1.043e-92	319.0	COG0477@1|root,arCOG02691@2157|Archaea,2XRK4@28889|Crenarchaeota	28889|Crenarchaeota	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
MMS3_k127_546553_20	1382304.JNIL01000001_gene1410	2.127e-115	381.0	COG1072@1|root,COG1072@2|Bacteria,1TPHJ@1239|Firmicutes,4HA4K@91061|Bacilli	91061|Bacilli	F	Pantothenic acid kinase	coaA	GO:0003674,GO:0003824,GO:0004594,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.1.33	ko:K00867	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PRK
MMS3_k127_546553_38	273063.STK_00730	1.336e-76	261.0	arCOG07343@1|root,arCOG07343@2157|Archaea,2XS2D@28889|Crenarchaeota	28889|Crenarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_546553_2	1128398.Curi_c29370	3.014e-226	730.0	COG3383@1|root,COG3383@2|Bacteria,1UI1F@1239|Firmicutes,25EAG@186801|Clostridia,26AM4@186813|unclassified Clostridiales	186801|Clostridia	C	Molybdopterin oxidoreductase Fe4S4 domain	fdhA2	-	1.17.1.10,1.17.1.11,1.17.1.9	ko:K00123,ko:K05299,ko:K22341	ko00630,ko00680,ko00720,ko01100,ko01120,ko01200,map00630,map00680,map00720,map01100,map01120,map01200	M00377	R00134,R00519	RC02796	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_4,Fer4,Fer4_6,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
MMS3_k127_546553_18	768679.TTX_1270	3.696e-122	409.0	COG1894@1|root,COG1905@1|root,arCOG04537@2157|Archaea,arCOG04890@2157|Archaea,2XRQD@28889|Crenarchaeota	28889|Crenarchaeota	C	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region	-	-	1.17.1.9,1.6.5.3	ko:K00122,ko:K00335	ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200	M00144	R00519,R11945	RC00061,RC02796	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S
MMS3_k127_546553_0	273116.14324457	0.0	1411.0	COG0243@1|root,arCOG01492@2157|Archaea,2Y8AB@28890|Euryarchaeota,2425G@183967|Thermoplasmata	183967|Thermoplasmata	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Fer4,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
MMS3_k127_546553_88	273116.14324458	6.842e-19	92.0	COG2427@1|root,arCOG07741@2157|Archaea	2157|Archaea	S	Protein of unknown function (DUF1641)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1641
MMS3_k127_546553_43	263820.PTO1037	7.875e-67	237.0	COG1526@1|root,arCOG04358@2157|Archaea,2XYNI@28890|Euryarchaeota,2427S@183967|Thermoplasmata	183967|Thermoplasmata	H	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH	fdhD	-	-	ko:K02379	-	-	-	-	ko00000	-	-	-	FdhD-NarQ
MMS3_k127_6013_17	273075.Ta1317	2.305e-17	89.0	arCOG05382@1|root,arCOG05382@2157|Archaea,2Y5Z0@28890|Euryarchaeota,242HQ@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_6013_16	263820.PTO1150	2.832e-29	120.0	COG1733@1|root,arCOG01057@2157|Archaea,2XY55@28890|Euryarchaeota,242DE@183967|Thermoplasmata	183967|Thermoplasmata	K	HxlR-like helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
MMS3_k127_6013_12	386043.lwe0754	9.241e-46	171.0	COG2353@1|root,COG2353@2|Bacteria,1V1NX@1239|Firmicutes,4HFXF@91061|Bacilli,26JPA@186820|Listeriaceae	91061|Bacilli	S	Belongs to the UPF0312 family	-	-	-	-	-	-	-	-	-	-	-	-	YceI
MMS3_k127_6013_3	273075.Ta0664	2.886e-131	440.0	COG1506@1|root,arCOG01646@2157|Archaea,2XU9I@28890|Euryarchaeota,2422H@183967|Thermoplasmata	183967|Thermoplasmata	E	Prolyl oligopeptidase family	-	-	3.4.21.26	ko:K01322	ko04614,map04614	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9
MMS3_k127_6013_18	368407.Memar_0788	3.262e-16	81.0	arCOG07473@1|root,arCOG07473@2157|Archaea,2Y1CW@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_6013_10	273075.Ta1410	1.545e-47	181.0	COG1120@1|root,arCOG00198@2157|Archaea,2XT76@28890|Euryarchaeota,242HX@183967|Thermoplasmata	183967|Thermoplasmata	E	ATPases associated with a variety of cellular activities	-	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
MMS3_k127_6013_6	273075.Ta0172	1.551e-92	316.0	COG0609@1|root,arCOG01007@2157|Archaea,2XT1A@28890|Euryarchaeota,241QA@183967|Thermoplasmata	183967|Thermoplasmata	P	FecCD transport family	-	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
MMS3_k127_6013_8	263820.PTO1318	1.903e-68	244.0	COG0614@1|root,arCOG04233@2157|Archaea,2Y67J@28890|Euryarchaeota,2427C@183967|Thermoplasmata	183967|Thermoplasmata	P	Periplasmic binding protein	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
MMS3_k127_6013_7	273116.14325668	1.292e-87	302.0	COG1078@1|root,arCOG04430@2157|Archaea,2XUT7@28890|Euryarchaeota,241PB@183967|Thermoplasmata	183967|Thermoplasmata	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K06885	-	-	-	-	ko00000	-	-	-	HD
MMS3_k127_6013_15	273116.14325478	1.664e-33	134.0	COG0456@1|root,arCOG00833@2157|Archaea,2Y7BR@28890|Euryarchaeota,242DG@183967|Thermoplasmata	183967|Thermoplasmata	K	FR47-like protein	-	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
MMS3_k127_6013_9	273116.14325477	1.179e-49	181.0	COG0615@1|root,arCOG01222@2157|Archaea,2XX70@28890|Euryarchaeota,241VG@183967|Thermoplasmata	183967|Thermoplasmata	F	Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme	ribL	-	2.7.7.2	ko:K14656	ko00740,ko01100,ko01110,map00740,map01100,map01110	-	R00161	RC00002	ko00000,ko00001,ko01000	-	-	-	CTP_transf_like
MMS3_k127_6013_11	273116.14324382	5.221e-46	173.0	COG0491@1|root,arCOG00504@2157|Archaea,2Y7BK@28890|Euryarchaeota,242CU@183967|Thermoplasmata	183967|Thermoplasmata	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
MMS3_k127_6013_19	439481.Aboo_0781	2.963e-12	76.0	COG1469@1|root,arCOG04301@2157|Archaea,2XT11@28890|Euryarchaeota,3F2JX@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin	mptA	GO:0003674,GO:0003824,GO:0003933,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044682	3.5.4.39	ko:K17488	ko00790,map00790	-	R10348	RC02504,RC03131	ko00000,ko00001,ko01000	-	-	-	GCHY-1
MMS3_k127_6013_14	273116.14325475	9.572e-34	133.0	COG1382@1|root,arCOG01342@2157|Archaea,2Y79P@28890|Euryarchaeota,241WC@183967|Thermoplasmata	183967|Thermoplasmata	O	Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding	pfdB	-	-	ko:K04798	-	-	-	-	ko00000,ko03110	-	-	-	Prefoldin_2
MMS3_k127_6013_2	1056495.Calag_0085	1.289e-137	448.0	COG1804@1|root,arCOG02304@2157|Archaea,2XPYW@28889|Crenarchaeota	28889|Crenarchaeota	C	PFAM L-carnitine dehydratase bile acid-inducible protein F	-	-	2.8.3.16,2.8.3.19	ko:K07749,ko:K18702	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
MMS3_k127_6013_20	330779.Saci_1729	6.005e-10	64.0	COG1545@1|root,arCOG01285@2157|Archaea	2157|Archaea	I	nucleic-acid-binding protein containing a Zn-ribbon	-	-	1.1.1.157	ko:K00074,ko:K07068	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	OB_aCoA_assoc
MMS3_k127_6013_4	930945.SiRe_2502	2.093e-119	395.0	COG0183@1|root,arCOG01278@2157|Archaea,2XPQD@28889|Crenarchaeota	28889|Crenarchaeota	I	PFAM Thiolase	-	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
MMS3_k127_6013_1	273116.14324447	5.56e-183	587.0	COG1902@1|root,arCOG00615@2157|Archaea,2XT27@28890|Euryarchaeota,241Z1@183967|Thermoplasmata	183967|Thermoplasmata	C	NADH:flavin oxidoreductase / NADH oxidase family	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_8,Oxidored_FMN
MMS3_k127_6013_0	1304284.L21TH_2367	1.516e-266	856.0	COG0458@1|root,COG0458@2|Bacteria,1TPID@1239|Firmicutes,2498I@186801|Clostridia,36DIP@31979|Clostridiaceae	186801|Clostridia	F	Carbamoyl-phosphate synthetase ammonia chain	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
MMS3_k127_6013_5	263820.PTO0900	7.163e-99	333.0	COG0505@1|root,arCOG00064@2157|Archaea,2XT0H@28890|Euryarchaeota,241SQ@183967|Thermoplasmata	183967|Thermoplasmata	F	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
MMS3_k127_6013_13	224324.aq_1250	3.601e-39	151.0	COG1881@1|root,COG1881@2|Bacteria,2G443@200783|Aquificae	200783|Aquificae	S	PFAM PEBP family protein	-	-	-	ko:K06910	-	-	-	-	ko00000	-	-	-	PBP
MMS3_k127_6013_21	40215.BBOS01000001_gene740	0.0009325	46.0	2EFG7@1|root,3398W@2|Bacteria	2|Bacteria	L	Recombination endonuclease VII	-	-	-	-	-	-	-	-	-	-	-	-	Endonuclease_7
MMS3_k127_60991_13	273116.14325335	4.241e-117	387.0	COG1303@1|root,arCOG01857@2157|Archaea,2XV35@28890|Euryarchaeota,241PF@183967|Thermoplasmata	183967|Thermoplasmata	J	Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs	-	-	2.1.1.206	ko:K07254	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	HD,Trm56
MMS3_k127_60991_22	273075.Ta0930	2.597e-76	258.0	COG4860@1|root,arCOG04366@2157|Archaea,2XYAX@28890|Euryarchaeota,241R5@183967|Thermoplasmata	183967|Thermoplasmata	K	ArsR transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	ArsR
MMS3_k127_60991_29	273075.Ta1302	6.105e-41	155.0	arCOG05357@1|root,arCOG05357@2157|Archaea,2Y1B1@28890|Euryarchaeota,242C7@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_60991_33	273116.14324577	1.394e-27	118.0	arCOG05359@1|root,arCOG05359@2157|Archaea,2Y4J3@28890|Euryarchaeota,242CB@183967|Thermoplasmata	183967|Thermoplasmata	S	Domain of unknown function (DUF1940)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1940
MMS3_k127_60991_24	263820.PTO0737	2.322e-58	213.0	COG0451@1|root,arCOG03016@2157|Archaea,2Y6ZK@28890|Euryarchaeota,2428Z@183967|Thermoplasmata	183967|Thermoplasmata	M	NAD(P)H-binding	-	-	1.6.5.3,1.6.99.3	ko:K00329,ko:K00356	ko00190,map00190	-	R11945	RC00061	ko00000,ko00001,ko01000	-	-	-	NAD_binding_10
MMS3_k127_60991_1	273075.Ta0351	3.881e-240	746.0	COG0183@1|root,arCOG01280@2157|Archaea,2Y85P@28890|Euryarchaeota,241YR@183967|Thermoplasmata	183967|Thermoplasmata	I	Thiolase, N-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
MMS3_k127_60991_20	273116.14325521	2.349e-80	272.0	COG1545@1|root,arCOG01287@2157|Archaea,2Y7AV@28890|Euryarchaeota,2427M@183967|Thermoplasmata	183967|Thermoplasmata	S	DUF35 OB-fold domain, acyl-CoA-associated	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
MMS3_k127_60991_6	263820.PTO0736	2.128e-142	468.0	COG1351@1|root,arCOG01884@2157|Archaea,2Y7AA@28890|Euryarchaeota,2420S@183967|Thermoplasmata	183967|Thermoplasmata	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant	-	-	-	-	-	-	-	-	-	-	-	-	Thy1
MMS3_k127_60991_0	273075.Ta0980	3.97e-265	824.0	COG0459@1|root,arCOG01257@2157|Archaea,2XUDQ@28890|Euryarchaeota,241IK@183967|Thermoplasmata	183967|Thermoplasmata	O	TCP-1/cpn60 chaperonin family	-	-	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
MMS3_k127_60991_8	572478.Vdis_1443	7.234e-137	448.0	COG2223@1|root,arCOG00148@2157|Archaea,2XRTQ@28889|Crenarchaeota	28889|Crenarchaeota	G	PFAM Major Facilitator Superfamily	-	-	-	ko:K02575	ko00910,map00910	M00615	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.8	-	-	MFS_1
MMS3_k127_60991_3	273116.14324489	2.677e-174	553.0	COG0045@1|root,arCOG01337@2157|Archaea,2XTSC@28890|Euryarchaeota,24256@183967|Thermoplasmata	183967|Thermoplasmata	C	ATP-grasp domain	-	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
MMS3_k127_60991_9	273116.14324488	2.654e-135	435.0	COG0074@1|root,arCOG01339@2157|Archaea,2XTI3@28890|Euryarchaeota,24232@183967|Thermoplasmata	183967|Thermoplasmata	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA
MMS3_k127_60991_12	273075.Ta1330	9.449e-122	397.0	COG0448@1|root,arCOG00912@2157|Archaea,2XTI4@28890|Euryarchaeota,241JI@183967|Thermoplasmata	183967|Thermoplasmata	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	arcB	-	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
MMS3_k127_60991_31	263820.PTO0719	2.36e-32	128.0	arCOG05358@1|root,arCOG05358@2157|Archaea,2Y1IF@28890|Euryarchaeota,242CT@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_60991_28	263820.PTO0718	3.846e-42	161.0	COG2263@1|root,arCOG00910@2157|Archaea,2XU4P@28890|Euryarchaeota,241V0@183967|Thermoplasmata	183967|Thermoplasmata	Q	Methyltransferase domain	-	-	-	ko:K07579	-	-	-	-	ko00000	-	-	-	MTS,PrmA
MMS3_k127_60991_35	273116.14325338	1.79e-25	106.0	COG1958@1|root,arCOG00998@2157|Archaea,2Y0B2@28890|Euryarchaeota,242CV@183967|Thermoplasmata	183967|Thermoplasmata	K	snRNP Sm proteins	-	-	-	ko:K04796	-	-	-	-	ko00000	-	-	-	LSM
MMS3_k127_60991_40	273116.14325339	1.979e-10	62.0	arCOG06962@1|root,arCOG06962@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_60991_30	273075.Ta0929	4.382e-35	142.0	COG1096@1|root,arCOG00676@2157|Archaea,2XYYA@28890|Euryarchaeota,241TD@183967|Thermoplasmata	183967|Thermoplasmata	J	Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs	csl4	-	-	ko:K07573	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	ECR1_N
MMS3_k127_60991_5	273116.14325333	1.183e-142	469.0	COG1549@1|root,arCOG00990@2157|Archaea,2XT9W@28890|Euryarchaeota,241NM@183967|Thermoplasmata	183967|Thermoplasmata	J	PUA domain	-	-	2.6.1.97	ko:K07557	-	-	-	-	ko00000,ko01000	-	-	-	PUA
MMS3_k127_60991_26	273116.14325332	7.411e-46	191.0	arCOG07398@1|root,arCOG07398@2157|Archaea	2157|Archaea	O	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Peptidase_S8
MMS3_k127_60991_34	273075.Ta0922	6.323e-26	114.0	arCOG07397@1|root,arCOG07397@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_60991_41	273116.14325330	2.796e-09	64.0	arCOG07743@1|root,arCOG07743@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_60991_11	273116.14325329	3.394e-124	405.0	COG0714@1|root,arCOG00434@2157|Archaea,2XSZU@28890|Euryarchaeota	28890|Euryarchaeota	S	ATPase associated with various cellular activities	moxR4	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
MMS3_k127_60991_17	273116.14325328	5.892e-87	303.0	COG1721@1|root,arCOG02742@2157|Archaea	2157|Archaea	S	protein (some members contain a von Willebrand factor type A (vWA) domain)	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
MMS3_k127_60991_39	273075.Ta0918	1.254e-16	90.0	arCOG07396@1|root,arCOG07396@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_60991_4	273075.Ta1060m	6.602e-154	496.0	COG0402@1|root,arCOG00695@2157|Archaea,2XTJS@28890|Euryarchaeota,241JE@183967|Thermoplasmata	183967|Thermoplasmata	F	Amidohydrolase family	-	-	3.5.4.28,3.5.4.31	ko:K12960	ko00270,ko01100,map00270,map01100	-	R09660	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
MMS3_k127_60991_14	263820.PTO0541	2.391e-112	370.0	COG0451@1|root,arCOG01369@2157|Archaea,2XTRS@28890|Euryarchaeota,2424I@183967|Thermoplasmata	183967|Thermoplasmata	M	Male sterility protein	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
MMS3_k127_60991_16	273075.Ta1377	1.599e-93	319.0	COG0477@1|root,arCOG00132@2157|Archaea	2157|Archaea	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
MMS3_k127_60991_36	273116.14325508	1.239e-23	106.0	COG1846@1|root,arCOG03181@2157|Archaea	2157|Archaea	K	Transcriptional regulator MarR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_27,MarR,MarR_2
MMS3_k127_60991_2	273075.Ta0410	8.946e-210	668.0	arCOG00144@1|root,arCOG00144@2157|Archaea,2XVRP@28890|Euryarchaeota,2420N@183967|Thermoplasmata	183967|Thermoplasmata	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS3_k127_60991_27	221027.JO40_12795	1.022e-43	174.0	COG0438@1|root,COG0438@2|Bacteria,2J7E2@203691|Spirochaetes	203691|Spirochaetes	M	PFAM Glycosyl transferases group 1	-	-	2.4.1.337	ko:K19002	ko00561,ko01100,map00561,map01100	-	R10850	RC00005,RC00059	ko00000,ko00001,ko01000,ko01003	-	GT4	-	Glyco_transf_4,Glycos_transf_1
MMS3_k127_60991_18	273075.Ta0480	2.34e-83	286.0	COG2423@1|root,arCOG01035@2157|Archaea,2XT4P@28890|Euryarchaeota,24266@183967|Thermoplasmata	183967|Thermoplasmata	E	Ornithine cyclodeaminase/mu-crystallin family	-	-	1.4.1.1	ko:K19244	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	OCD_Mu_crystall
MMS3_k127_60991_37	273075.Ta1422	2.118e-20	93.0	arCOG05376@1|root,arCOG05376@2157|Archaea,2Y4VU@28890|Euryarchaeota,242E3@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_60991_7	273116.14324634	3.987e-141	454.0	COG1899@1|root,arCOG04142@2157|Archaea,2XSTD@28890|Euryarchaeota,241J4@183967|Thermoplasmata	183967|Thermoplasmata	J	Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue	dys	-	2.5.1.46	ko:K00809	-	-	-	-	ko00000,ko01000	-	-	-	DS
MMS3_k127_60991_32	263820.PTO1208	8.669e-29	121.0	COG5615@1|root,arCOG05392@2157|Archaea,2Y453@28890|Euryarchaeota,2429S@183967|Thermoplasmata	183967|Thermoplasmata	S	protein, homolog of Cu resistance protein CopC	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_60991_19	273116.14324377	3.687e-81	275.0	COG0049@1|root,arCOG04254@2157|Archaea,2XTDC@28890|Euryarchaeota,241NY@183967|Thermoplasmata	183967|Thermoplasmata	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center	rps7	-	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
MMS3_k127_60991_23	263820.PTO0853	1.633e-72	248.0	COG0048@1|root,arCOG04255@2157|Archaea,2XX4A@28890|Euryarchaeota,241NK@183967|Thermoplasmata	183967|Thermoplasmata	J	With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits	rps12	-	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
MMS3_k127_60991_15	263820.PTO0852	6.295e-108	364.0	COG0012@1|root,arCOG00357@2157|Archaea,2XTZG@28890|Euryarchaeota,241MD@183967|Thermoplasmata	183967|Thermoplasmata	J	GTPase of unknown function C-terminal	-	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,MMR_HSR1_C,TGS
MMS3_k127_60991_25	273116.14325488	6.602e-52	186.0	COG1860@1|root,arCOG04477@2157|Archaea,2XX8X@28890|Euryarchaeota,241W0@183967|Thermoplasmata	183967|Thermoplasmata	S	Uncharacterised protein family (UPF0179)	-	-	-	ko:K09730	-	-	-	-	ko00000	-	-	-	UPF0179
MMS3_k127_60991_10	263820.PTO0850	3.615e-131	427.0	COG0371@1|root,arCOG00982@2157|Archaea,2XT0F@28890|Euryarchaeota,241M3@183967|Thermoplasmata	183967|Thermoplasmata	C	Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea	egsA	-	1.1.1.261	ko:K00096	ko00564,map00564	-	R05679,R05680	RC00029	ko00000,ko00001,ko01000	-	-	-	Fe-ADH_2
MMS3_k127_60991_21	439481.Aboo_0974	5.468e-78	269.0	COG1446@1|root,arCOG04779@2157|Archaea,2XTTT@28890|Euryarchaeota,3F316@33867|unclassified Euryarchaeota	28890|Euryarchaeota	E	Asparaginase	ansA	-	3.4.19.5,3.5.1.1	ko:K01424,ko:K13051	ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110	-	R00485	RC00010,RC02798	ko00000,ko00001,ko01000,ko01002	-	-	-	Asparaginase_2
MMS3_k127_654340_31	1033806.HTIA_p3068	2.079e-16	90.0	arCOG04518@1|root,arCOG04518@2157|Archaea,2XUD7@28890|Euryarchaeota,23SZS@183963|Halobacteria	183963|Halobacteria	K	Transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,MarR_2,TrmB
MMS3_k127_654340_27	192952.MM_2974	1.358e-22	106.0	arCOG04041@1|root,arCOG04041@2157|Archaea,arCOG07592@2157|Archaea,2XV04@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_654340_7	1157640.AQWO01000022_gene1732	2.262e-123	402.0	COG1028@1|root,COG1028@2|Bacteria,2GKI2@201174|Actinobacteria	201174|Actinobacteria	IQ	short-chain dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
MMS3_k127_654340_21	928724.SacglDRAFT_03354	8.295e-47	176.0	COG0451@1|root,COG0451@2|Bacteria,2I2SW@201174|Actinobacteria,4E2YP@85010|Pseudonocardiales	201174|Actinobacteria	GM	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase,NAD_binding_10
MMS3_k127_654340_11	273116.14324585	1.031e-78	271.0	COG0723@1|root,arCOG01720@2157|Archaea	2157|Archaea	C	PFAM Rieske 2Fe-2S domain	soxL	-	-	-	-	-	-	-	-	-	-	-	Rieske
MMS3_k127_654340_4	273116.14324586	9.502e-163	528.0	COG1290@1|root,arCOG01721@2157|Archaea,2XVE0@28890|Euryarchaeota	28890|Euryarchaeota	C	COG1290 Cytochrome b subunit of the bc complex	petB2	-	-	ko:K15879	-	-	-	-	ko00000	-	-	-	Cytochrom_B_C,Cytochrom_B_N_2
MMS3_k127_654340_19	273116.14324580	9.572e-56	213.0	arCOG06974@1|root,arCOG06974@2157|Archaea,2Y4TI@28890|Euryarchaeota,242C1@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_654340_17	1237500.ANBA01000009_gene1044	1.384e-61	228.0	COG3214@1|root,COG3214@2|Bacteria,2GJM7@201174|Actinobacteria,4EGXC@85012|Streptosporangiales	201174|Actinobacteria	S	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_42
MMS3_k127_654340_18	273116.14324927	8.016e-61	218.0	COG1028@1|root,arCOG01259@2157|Archaea,2XTZX@28890|Euryarchaeota	28890|Euryarchaeota	I	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	ywfD2	-	1.1.1.100,1.1.1.47	ko:K00034,ko:K00059	ko00030,ko00061,ko00333,ko00780,ko01040,ko01100,ko01120,ko01130,ko01200,ko01212,map00030,map00061,map00333,map00780,map01040,map01100,map01120,map01130,map01200,map01212	M00083,M00572	R01520,R01521,R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00066,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
MMS3_k127_654340_14	273116.14325455	3.466e-72	250.0	COG1756@1|root,arCOG04122@2157|Archaea,2XX9G@28890|Euryarchaeota,24276@183967|Thermoplasmata	183967|Thermoplasmata	J	Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA	nep1	-	2.1.1.260	ko:K14568	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko03009	-	-	-	EMG1
MMS3_k127_654340_24	263820.PTO0244	1.045e-39	151.0	COG0184@1|root,arCOG04185@2157|Archaea,2XWKV@28890|Euryarchaeota,241UD@183967|Thermoplasmata	183967|Thermoplasmata	J	structural constituent of ribosome	rps15	-	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13_N,Ribosomal_S15
MMS3_k127_654340_5	273116.14325470	2.893e-146	475.0	COG0608@1|root,arCOG00427@2157|Archaea,2XW5A@28890|Euryarchaeota,241PR@183967|Thermoplasmata	183967|Thermoplasmata	L	DHHA1 domain	-	-	-	ko:K07463	-	-	-	-	ko00000	-	-	-	DHH,DHHA1
MMS3_k127_654340_20	263820.PTO0788	1.889e-51	189.0	arCOG03142@1|root,arCOG03142@2157|Archaea,2XTSE@28890|Euryarchaeota,24268@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_654340_23	273075.Ta1135	1.607e-43	168.0	arCOG05366@1|root,arCOG05366@2157|Archaea,2Y11W@28890|Euryarchaeota,241WB@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	CARDB
MMS3_k127_654340_0	273116.14325473	0.0	1446.0	COG1287@1|root,arCOG05365@2157|Archaea,2Y7QJ@28890|Euryarchaeota,241Y6@183967|Thermoplasmata	183967|Thermoplasmata	I	oligosaccharyl transferase activity	-	-	2.4.99.18	ko:K07151	ko00510,ko00513,ko01100,ko04141,map00510,map00513,map01100,map04141	M00072	R04216,R05976	RC00005,RC00482	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT66	-	PMT_2
MMS3_k127_654340_29	536227.CcarbDRAFT_1860	5.496e-20	96.0	COG1116@1|root,COG1116@2|Bacteria,1TRM6@1239|Firmicutes,248CG@186801|Clostridia,36GMS@31979|Clostridiaceae	186801|Clostridia	P	ABC-type nitrate sulfonate bicarbonate transport system ATPase component	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	AAA_assoc_C,ABC_tran
MMS3_k127_654340_22	263820.PTO0783	6.64e-44	173.0	COG3888@1|root,arCOG01804@2157|Archaea,2XXE6@28890|Euryarchaeota,2428P@183967|Thermoplasmata	183967|Thermoplasmata	K	COGs COG3888 transcriptional regulator protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR
MMS3_k127_654340_32	273116.14325610	1.497e-15	80.0	COG0640@1|root,arCOG00394@2157|Archaea,2Y5A1@28890|Euryarchaeota,242H3@183967|Thermoplasmata	183967|Thermoplasmata	K	transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_654340_10	263820.PTO1115	5.505e-87	296.0	COG0517@1|root,arCOG00600@2157|Archaea,2XU4J@28890|Euryarchaeota,241RP@183967|Thermoplasmata	183967|Thermoplasmata	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
MMS3_k127_654340_25	479434.Sthe_1526	1.97e-30	123.0	COG0822@1|root,COG0822@2|Bacteria,2G71H@200795|Chloroflexi,27YGN@189775|Thermomicrobia	189775|Thermomicrobia	C	SUF system FeS assembly protein, NifU family	-	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
MMS3_k127_654340_8	1121936.AUHI01000011_gene1057	4.387e-115	384.0	COG0520@1|root,COG0520@2|Bacteria,1TQ1W@1239|Firmicutes,4HA6Z@91061|Bacilli	91061|Bacilli	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	sufS	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
MMS3_k127_654340_12	273075.Ta0204	3.339e-78	276.0	COG0719@1|root,arCOG01715@2157|Archaea,2Y3DN@28890|Euryarchaeota,2426Z@183967|Thermoplasmata	183967|Thermoplasmata	O	Uncharacterized protein family (UPF0051)	-	-	-	ko:K07033	-	-	-	-	ko00000	-	-	-	UPF0051
MMS3_k127_654340_1	273116.14325655	8.495e-250	777.0	COG0719@1|root,arCOG01715@2157|Archaea,2XTY9@28890|Euryarchaeota,241R3@183967|Thermoplasmata	183967|Thermoplasmata	O	Uncharacterized protein family (UPF0051)	-	-	-	ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
MMS3_k127_654340_9	263820.PTO1111	1.7e-106	350.0	COG0396@1|root,arCOG04236@2157|Archaea,2XT6T@28890|Euryarchaeota,241QJ@183967|Thermoplasmata	183967|Thermoplasmata	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
MMS3_k127_654340_16	273116.14325657	5.824e-62	220.0	COG2345@1|root,arCOG01691@2157|Archaea,2Y7BG@28890|Euryarchaeota,242BG@183967|Thermoplasmata	183967|Thermoplasmata	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5
MMS3_k127_654340_26	273116.14325688	6.38e-27	118.0	COG2345@1|root,arCOG01692@2157|Archaea	2157|Archaea	K	HTH domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
MMS3_k127_654340_2	273075.Ta0098	1.708e-229	719.0	COG0466@1|root,arCOG02162@2157|Archaea,2XVMC@28890|Euryarchaeota,241M7@183967|Thermoplasmata	183967|Thermoplasmata	O	ATP-dependent peptidase activity	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA_32,Mg_chelatase,Sigma54_activat
MMS3_k127_654340_3	273075.Ta0097m	3.423e-173	553.0	COG0358@1|root,arCOG04281@2157|Archaea,2XTHB@28890|Euryarchaeota,241KR@183967|Thermoplasmata	183967|Thermoplasmata	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	Toprim_4
MMS3_k127_654340_6	263820.PTO0616	1.596e-136	447.0	COG0648@1|root,arCOG01894@2157|Archaea,2XU62@28890|Euryarchaeota,241P4@183967|Thermoplasmata	183967|Thermoplasmata	L	Xylose isomerase-like TIM barrel	-	-	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
MMS3_k127_654340_30	263820.PTO0615	4.508e-17	94.0	COG4004@1|root,arCOG04412@2157|Archaea,2Y1TD@28890|Euryarchaeota,242GF@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_654340_13	263820.PTO1356	8.063e-76	266.0	COG3407@1|root,arCOG02937@2157|Archaea,2Y6X7@28890|Euryarchaeota,241XR@183967|Thermoplasmata	183967|Thermoplasmata	F	Catalyzes the phosphorylation of mevalonate (MVA) to yield mevalonate-3-phosphate. Functions in an alternative	-	GO:0003674,GO:0003824,GO:0006084,GO:0006139,GO:0006163,GO:0006629,GO:0006637,GO:0006644,GO:0006720,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009117,GO:0009150,GO:0009240,GO:0009259,GO:0009987,GO:0016740,GO:0016772,GO:0016773,GO:0019287,GO:0019637,GO:0019693,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046483,GO:0046490,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901135,GO:1901360,GO:1901564,GO:1901576	2.7.1.185	ko:K18689	ko00900,ko01110,ko01130,map00900,map01110,map01130	-	R10779	RC00002,RC01439	ko00000,ko00001,ko01000	-	-	-	-
MMS3_k127_654340_15	273075.Ta0378	6.38e-68	240.0	COG0681@1|root,arCOG01739@2157|Archaea,2Y79C@28890|Euryarchaeota,241T8@183967|Thermoplasmata	183967|Thermoplasmata	U	Signal peptidase	-	-	3.4.21.89	ko:K13280	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	-
MMS3_k127_654340_28	273116.14324537	4.767e-20	91.0	COG4023@1|root,arCOG02957@2157|Archaea,2Y1AH@28890|Euryarchaeota,242FI@183967|Thermoplasmata	183967|Thermoplasmata	U	but it may be involved in stabilization of the trimeric complex	secG	-	-	-	-	-	-	-	-	-	-	-	Sec61_beta
MMS3_k127_656301_10	273075.Ta0428	4.419e-32	127.0	COG2146@1|root,arCOG02852@2157|Archaea,2Y7BW@28890|Euryarchaeota,242EM@183967|Thermoplasmata	183967|Thermoplasmata	P	Rieske-like [2Fe-2S] domain	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
MMS3_k127_656301_0	273075.Ta0429	1.722e-150	494.0	COG2025@1|root,arCOG00448@2157|Archaea,2Y2B4@28890|Euryarchaeota,2424H@183967|Thermoplasmata	183967|Thermoplasmata	C	Electron transfer flavoprotein domain	-	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
MMS3_k127_656301_7	632335.Calkr_2020	3.347e-46	173.0	COG1878@1|root,COG1878@2|Bacteria,1UFUJ@1239|Firmicutes,24HGD@186801|Clostridia,42GJQ@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM cyclase family protein	-	-	3.5.1.9	ko:K07130	ko00380,ko00630,ko01100,map00380,map00630,map01100	M00038	R00988,R01959,R04911	RC00263,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Cyclase
MMS3_k127_656301_11	196162.Noca_4890	4.009e-15	80.0	COG0425@1|root,COG0425@2|Bacteria,2GSNH@201174|Actinobacteria	201174|Actinobacteria	O	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
MMS3_k127_656301_9	273116.14324335	1.942e-35	140.0	COG1439@1|root,arCOG00721@2157|Archaea,2XWH2@28890|Euryarchaeota,241TG@183967|Thermoplasmata	183967|Thermoplasmata	V	PIN domain of ribonuclease	-	-	-	ko:K07060	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PIN_6
MMS3_k127_656301_2	273116.14324343	1.028e-113	382.0	COG0063@1|root,arCOG00018@2157|Archaea,2XU4W@28890|Euryarchaeota,241NJ@183967|Thermoplasmata	183967|Thermoplasmata	G	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
MMS3_k127_656301_6	273116.14324274	4.915e-54	196.0	COG1059@1|root,arCOG04357@2157|Archaea,2XWSZ@28890|Euryarchaeota,24286@183967|Thermoplasmata	183967|Thermoplasmata	L	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites)	ogg	-	4.2.99.18	ko:K03653	-	-	-	-	ko00000,ko01000	-	-	-	-
MMS3_k127_656301_3	273116.14324273	7.204e-89	301.0	COG0605@1|root,arCOG04147@2157|Archaea,2XUDD@28890|Euryarchaeota,24210@183967|Thermoplasmata	183967|Thermoplasmata	P	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	-	-	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
MMS3_k127_656301_8	797210.Halxa_0138	9.379e-36	145.0	arCOG02274@1|root,arCOG02274@2157|Archaea,2XVHG@28890|Euryarchaeota,23SZN@183963|Halobacteria	183963|Halobacteria	K	DNA binding protein	-	-	-	ko:K06930	-	-	-	-	ko00000	-	-	-	HTH_10
MMS3_k127_656301_1	273116.14324271	1.153e-139	456.0	COG0404@1|root,arCOG00756@2157|Archaea,2XU1F@28890|Euryarchaeota,241ZF@183967|Thermoplasmata	183967|Thermoplasmata	H	Aminomethyltransferase folate-binding domain	-	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
MMS3_k127_656301_4	273116.14324270	8.742e-61	216.0	COG0311@1|root,arCOG00034@2157|Archaea,2XTZS@28890|Euryarchaeota,241RU@183967|Thermoplasmata	183967|Thermoplasmata	H	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS	pdxT	-	4.3.3.6	ko:K08681	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SNO
MMS3_k127_656301_12	272562.CA_C0925	5.169e-10	70.0	COG0457@1|root,COG0457@2|Bacteria	272562.CA_C0925|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_656301_5	269797.Mbar_A3302	2.114e-55	200.0	COG1335@1|root,arCOG01943@2157|Archaea,2Y0WZ@28890|Euryarchaeota,2NA9S@224756|Methanomicrobia	224756|Methanomicrobia	Q	PFAM Isochorismatase	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
MMS3_k127_656301_13	267377.MMP0574	0.0006651	42.0	arCOG06624@1|root,arCOG06624@2157|Archaea	2157|Archaea	-	-	rpl41e	-	-	ko:K02928	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	-
MMS3_k127_72131_21	1211817.CCAT010000065_gene512	5.859e-07	51.0	COG1670@1|root,COG1670@2|Bacteria,1UHG9@1239|Firmicutes,24I22@186801|Clostridia,36IX3@31979|Clostridiaceae	186801|Clostridia	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
MMS3_k127_72131_2	273116.14325756	1.726e-138	456.0	COG1111@1|root,arCOG00872@2157|Archaea,2XTBV@28890|Euryarchaeota,24250@183967|Thermoplasmata	183967|Thermoplasmata	L	helicase superfamily c-terminal domain	-	-	-	ko:K10896	ko03460,map03460	M00413	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	Helicase_C,ResIII
MMS3_k127_72131_3	273116.14325757	1.65e-123	404.0	COG0470@1|root,arCOG00469@2157|Archaea,2XTC8@28890|Euryarchaeota,241K8@183967|Thermoplasmata	183967|Thermoplasmata	L	Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA	rfcS	-	-	ko:K04801	ko03030,map03030	-	-	-	ko00000,ko00001,ko03032	-	-	-	AAA,Rep_fac_C
MMS3_k127_72131_12	263820.PTO0379	1.406e-52	192.0	COG0299@1|root,arCOG02825@2157|Archaea,2Y838@28890|Euryarchaeota,2427V@183967|Thermoplasmata	183967|Thermoplasmata	F	Formyl transferase	-	-	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	Formyl_trans_N
MMS3_k127_72131_20	436308.Nmar_0623	6.376e-08	64.0	arCOG08741@1|root,arCOG08741@2157|Archaea,41SWQ@651137|Thaumarchaeota	651137|Thaumarchaeota	E	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
MMS3_k127_72131_10	273116.14324348	2.716e-64	222.0	COG1545@1|root,arCOG01285@2157|Archaea,2XXGF@28890|Euryarchaeota,241SY@183967|Thermoplasmata	183967|Thermoplasmata	V	DUF35 OB-fold domain, acyl-CoA-associated	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
MMS3_k127_72131_4	572546.Arcpr_0145	4.467e-90	310.0	COG0183@1|root,arCOG01278@2157|Archaea,2XT38@28890|Euryarchaeota,245TY@183980|Archaeoglobi	183980|Archaeoglobi	I	Thiolase, C-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
MMS3_k127_72131_0	273075.Ta1455	1.24e-188	595.0	COG3425@1|root,arCOG01767@2157|Archaea,2XTWE@28890|Euryarchaeota,241IW@183967|Thermoplasmata	183967|Thermoplasmata	I	transferase activity, transferring acyl groups	-	-	2.3.3.10	ko:K01641	ko00072,ko00280,ko00650,ko00900,ko01100,ko01110,ko01130,map00072,map00280,map00650,map00900,map01100,map01110,map01130	M00088,M00095	R01978	RC00004,RC00503	ko00000,ko00001,ko00002,ko01000	-	-	-	ACP_syn_III_C
MMS3_k127_72131_1	273075.Ta1430	6.073e-141	456.0	COG2237@1|root,arCOG04151@2157|Archaea,2XTV5@28890|Euryarchaeota,241T0@183967|Thermoplasmata	183967|Thermoplasmata	S	Domain of unknown function (DUF373)	-	-	-	ko:K08975	-	-	-	-	ko00000	-	-	-	DUF373
MMS3_k127_72131_14	273075.Ta1431	9.212e-40	156.0	COG1634@1|root,arCOG04303@2157|Archaea,2XT8R@28890|Euryarchaeota,241R2@183967|Thermoplasmata	183967|Thermoplasmata	H	Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6- hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP)	mptE	-	2.7.6.3	ko:K07142	ko00790,map00790	-	R03503	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	MAF_flag10
MMS3_k127_72131_13	263820.PTO0436	6.971e-41	159.0	COG2045@1|root,arCOG04871@2157|Archaea,2Y673@28890|Euryarchaeota,2429Z@183967|Thermoplasmata	183967|Thermoplasmata	H	2-phosphosulfolactate phosphatase activity	comB	-	3.1.3.71	ko:K05979	ko00680,ko01120,map00680,map01120	M00358	R05789	RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	2-ph_phosp
MMS3_k127_72131_9	273116.14324639	2.352e-66	229.0	COG0080@1|root,arCOG04372@2157|Archaea,2XTJN@28890|Euryarchaeota,241RW@183967|Thermoplasmata	183967|Thermoplasmata	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rpl11	-	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
MMS3_k127_72131_7	273075.Ta0360	2.59e-78	267.0	COG0081@1|root,arCOG04289@2157|Archaea,2XTJF@28890|Euryarchaeota,241NX@183967|Thermoplasmata	183967|Thermoplasmata	J	Binds directly to 23S rRNA. Probably involved in E site tRNA release	rpl1	-	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
MMS3_k127_72131_6	263820.PTO0439	2.875e-86	295.0	COG0244@1|root,arCOG04288@2157|Archaea,2XU7C@28890|Euryarchaeota,241SB@183967|Thermoplasmata	183967|Thermoplasmata	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rpl10	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
MMS3_k127_72131_16	272844.PAB1168	5.865e-26	110.0	COG2058@1|root,arCOG04287@2157|Archaea,2XYQ9@28890|Euryarchaeota,244BE@183968|Thermococci	183968|Thermococci	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rpl12	-	-	ko:K02869	ko03010,map03010	M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_60s
MMS3_k127_72131_11	273075.Ta0357	5.453e-61	213.0	COG1225@1|root,arCOG00310@2157|Archaea,2XX5A@28890|Euryarchaeota,241TT@183967|Thermoplasmata	183967|Thermoplasmata	O	Redoxin	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
MMS3_k127_72131_15	273116.14325705	4.382e-32	130.0	COG2016@1|root,arCOG00985@2157|Archaea,2XX1R@28890|Euryarchaeota,241XH@183967|Thermoplasmata	183967|Thermoplasmata	J	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase	-	-	-	ko:K07575	-	-	-	-	ko00000	-	-	-	DUF1947,PUA
MMS3_k127_72131_8	273116.14325706	5.195e-78	278.0	arCOG05338@1|root,arCOG05338@2157|Archaea,2Y1WT@28890|Euryarchaeota,24288@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_72131_5	273075.Ta1425	1.076e-86	295.0	COG0250@1|root,arCOG01920@2157|Archaea,2XWGQ@28890|Euryarchaeota,241QW@183967|Thermoplasmata	183967|Thermoplasmata	K	Transcription elongation factor Spt5	spt5	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,Spt5-NGN
MMS3_k127_72131_17	273075.Ta1426m	1.695e-22	98.0	COG2443@1|root,arCOG02204@2157|Archaea,2Y6IT@28890|Euryarchaeota,241W4@183967|Thermoplasmata	183967|Thermoplasmata	U	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation	-	-	-	ko:K07342	ko03060,ko04141,ko04145,ko05110,map03060,map04141,map04145,map05110	M00401	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.7,3.A.5.8,3.A.5.9	-	-	-
MMS3_k127_829808_1	1051632.TPY_2077	9.674e-31	132.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS3_k127_829808_2	273063.STK_11730	2.054e-11	70.0	COG5592@1|root,arCOG05367@2157|Archaea	2157|Archaea	S	Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
MMS3_k127_829808_3	673860.AciM339_0872	3.515e-11	69.0	COG1733@1|root,arCOG01057@2157|Archaea,2Y74W@28890|Euryarchaeota,3F3EI@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_829808_4	1382304.JNIL01000001_gene1732	1.331e-06	59.0	COG1664@1|root,COG1664@2|Bacteria	2|Bacteria	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
MMS3_k127_829808_0	273116.14324939	1.254e-45	181.0	COG0477@1|root,arCOG00135@2157|Archaea	2157|Archaea	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS3_k127_971280_25	460265.Mnod_2431	3.535e-52	207.0	COG0457@1|root,COG4249@1|root,COG0457@2|Bacteria,COG4249@2|Bacteria,1RKBA@1224|Proteobacteria,2TRAV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14,TPR_1,TPR_11,TPR_16,TPR_2,TPR_8
MMS3_k127_971280_2	246194.CHY_2411	4.915e-158	517.0	COG0318@1|root,COG0318@2|Bacteria,1TPSX@1239|Firmicutes,248JC@186801|Clostridia,42FN9@68295|Thermoanaerobacterales	186801|Clostridia	IQ	PFAM AMP-dependent synthetase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
MMS3_k127_971280_45	224325.AF_0483	8.588e-07	53.0	arCOG06113@1|root,arCOG06113@2157|Archaea,2Y130@28890|Euryarchaeota,246GP@183980|Archaeoglobi	183980|Archaeoglobi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_971280_34	42256.RradSPS_2260	1.506e-38	152.0	COG1926@1|root,COG1926@2|Bacteria,2GJUU@201174|Actinobacteria,4CQ98@84995|Rubrobacteria	84995|Rubrobacteria	S	Phosphoribosyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
MMS3_k127_971280_4	330779.Saci_1769	2.675e-142	467.0	COG3511@1|root,arCOG05966@2157|Archaea,2XRK9@28889|Crenarchaeota	2157|Archaea	M	Phosphoesterase family	-	-	-	-	-	-	-	-	-	-	-	-	Phosphoesterase
MMS3_k127_971280_6	263820.PTO0976	1.474e-122	413.0	COG1132@1|root,arCOG02841@2157|Archaea,2XSW0@28890|Euryarchaeota,2426N@183967|Thermoplasmata	183967|Thermoplasmata	P	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
MMS3_k127_971280_12	656519.Halsa_0250	6.998e-85	303.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia,3WB1I@53433|Halanaerobiales	186801|Clostridia	P	ABC transporter, transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
MMS3_k127_971280_31	399549.Msed_1207	3.237e-46	172.0	arCOG06267@1|root,arCOG06267@2157|Archaea	2157|Archaea	V	antibiotic catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS3_k127_971280_5	263820.PTO0640	4.378e-129	420.0	COG0087@1|root,arCOG04070@2157|Archaea,2XT9B@28890|Euryarchaeota,241MA@183967|Thermoplasmata	183967|Thermoplasmata	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rpl3	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
MMS3_k127_971280_11	273116.14324544	4.161e-87	295.0	COG0469@1|root,arCOG04071@2157|Archaea,2XTXX@28890|Euryarchaeota,241PY@183967|Thermoplasmata	183967|Thermoplasmata	J	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome	rpl4	-	-	ko:K02930	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
MMS3_k127_971280_39	273116.14324545	3.87e-24	105.0	COG0089@1|root,arCOG04072@2157|Archaea,2XYPG@28890|Euryarchaeota,241X4@183967|Thermoplasmata	183967|Thermoplasmata	J	Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome	rpl23	-	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
MMS3_k127_971280_10	263820.PTO0643	9.798e-99	326.0	COG0090@1|root,arCOG04067@2157|Archaea,2XTCS@28890|Euryarchaeota,241PZ@183967|Thermoplasmata	183967|Thermoplasmata	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rpl2	-	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2_C
MMS3_k127_971280_18	263820.PTO0644	2.967e-67	231.0	COG0185@1|root,arCOG04099@2157|Archaea,2XWI9@28890|Euryarchaeota,241QN@183967|Thermoplasmata	183967|Thermoplasmata	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rps19p	-	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
MMS3_k127_971280_24	273075.Ta1266	4.657e-55	196.0	COG0091@1|root,arCOG04098@2157|Archaea,2XWGN@28890|Euryarchaeota,241UI@183967|Thermoplasmata	183967|Thermoplasmata	J	This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome	rpl22	-	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
MMS3_k127_971280_14	273116.14324549	2.4e-82	287.0	COG0092@1|root,arCOG04097@2157|Archaea,2XTHR@28890|Euryarchaeota,241P0@183967|Thermoplasmata	183967|Thermoplasmata	J	Binds the lower part of the 30S subunit head	rps3	-	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
MMS3_k127_971280_43	263820.PTO0647	1.359e-15	78.0	COG0255@1|root,arCOG00785@2157|Archaea,2Y6IK@28890|Euryarchaeota,241WF@183967|Thermoplasmata	183967|Thermoplasmata	J	Belongs to the universal ribosomal protein uL29 family	rpl29	-	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
MMS3_k127_971280_32	263820.PTO0648	7.684e-45	167.0	COG0023@1|root,arCOG04223@2157|Archaea,2XXW5@28890|Euryarchaeota,241TJ@183967|Thermoplasmata	183967|Thermoplasmata	J	posttranscriptional regulation of gene expression	-	-	-	ko:K03113	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	SUI1
MMS3_k127_971280_46	589924.Ferp_1144	3.554e-05	49.0	COG1588@1|root,arCOG00784@2157|Archaea,2Y0G7@28890|Euryarchaeota,246HT@183980|Archaeoglobi	183980|Archaeoglobi	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp1	-	3.1.26.5	ko:K03538	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03016,ko03029	-	-	-	UPF0086
MMS3_k127_971280_35	273075.Ta1262	4.615e-37	142.0	COG0186@1|root,arCOG04096@2157|Archaea,2XYPE@28890|Euryarchaeota,241UC@183967|Thermoplasmata	183967|Thermoplasmata	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rps17	-	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
MMS3_k127_971280_20	263820.PTO0650	1.299e-65	226.0	COG0093@1|root,arCOG04095@2157|Archaea,2XWM6@28890|Euryarchaeota,241QD@183967|Thermoplasmata	183967|Thermoplasmata	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rpl14	-	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
MMS3_k127_971280_38	273116.14324555	3.986e-25	111.0	COG0198@1|root,arCOG04094@2157|Archaea,2XXV4@28890|Euryarchaeota,241WI@183967|Thermoplasmata	183967|Thermoplasmata	J	One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rpl24	-	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L26
MMS3_k127_971280_16	273116.14324556	1.573e-71	248.0	COG1471@1|root,arCOG04093@2157|Archaea,2XT03@28890|Euryarchaeota,241SU@183967|Thermoplasmata	183967|Thermoplasmata	J	rRNA binding	rps4e	-	-	ko:K02987	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	RS4NT,Ribosomal_S4e,S4
MMS3_k127_971280_15	263820.PTO0653	5.27e-72	247.0	COG0094@1|root,arCOG04092@2157|Archaea,2XTRN@28890|Euryarchaeota,241QF@183967|Thermoplasmata	183967|Thermoplasmata	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rpl5	-	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
MMS3_k127_971280_41	673860.AciM339_1112	4.186e-20	90.0	COG0199@1|root,arCOG00782@2157|Archaea,2Y68V@28890|Euryarchaeota,3F2V3@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	ribosomal protein S14	rps14	-	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
MMS3_k127_971280_21	263820.PTO0655	5.76e-61	212.0	COG0096@1|root,arCOG04091@2157|Archaea,2XWMU@28890|Euryarchaeota,241Q9@183967|Thermoplasmata	183967|Thermoplasmata	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rps8	-	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
MMS3_k127_971280_22	263820.PTO0656	3.436e-59	209.0	COG0097@1|root,arCOG04090@2157|Archaea,2XTIS@28890|Euryarchaeota,241S0@183967|Thermoplasmata	183967|Thermoplasmata	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rpl6	-	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
MMS3_k127_971280_26	439481.Aboo_1504	1.617e-50	182.0	COG1717@1|root,arCOG00781@2157|Archaea,2XSZ4@28890|Euryarchaeota,3F2PV@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Belongs to the eukaryotic ribosomal protein eL32 family	rpl32e	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02912	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	HHH_5,Ribosomal_L32e
MMS3_k127_971280_29	263820.PTO0658	7.444e-48	175.0	COG2147@1|root,arCOG04089@2157|Archaea,2XWU1@28890|Euryarchaeota,241SR@183967|Thermoplasmata	183967|Thermoplasmata	J	binds to the 23S rRNA	rpl19e	-	-	ko:K02885	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19e
MMS3_k127_971280_28	273075.Ta1252m	1.399e-48	178.0	COG0256@1|root,arCOG04088@2157|Archaea,2XTWT@28890|Euryarchaeota,241TI@183967|Thermoplasmata	183967|Thermoplasmata	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rpl18	-	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5e
MMS3_k127_971280_8	263820.PTO0660	2.703e-109	357.0	COG0098@1|root,arCOG04087@2157|Archaea,2XUQU@28890|Euryarchaeota,241N3@183967|Thermoplasmata	183967|Thermoplasmata	J	With S4 and S12 plays an important role in translational accuracy	rps5	-	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
MMS3_k127_971280_40	1163730.FFONT_0499	3.277e-23	105.0	COG1841@1|root,arCOG04086@2157|Archaea,2XQFR@28889|Crenarchaeota	28889|Crenarchaeota	J	PFAM ribosomal protein L30	rpl30	GO:0000463,GO:0000470,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
MMS3_k127_971280_30	273116.14324566	8.919e-47	172.0	COG0200@1|root,arCOG00779@2157|Archaea,2Y6A4@28890|Euryarchaeota,241UA@183967|Thermoplasmata	183967|Thermoplasmata	J	Binds to the 23S rRNA	rpl15	-	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
MMS3_k127_971280_0	263820.PTO0663	8.45e-279	866.0	COG5253@1|root,arCOG04169@2157|Archaea,2XT9A@28890|Euryarchaeota,241IV@183967|Thermoplasmata	183967|Thermoplasmata	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	Plug_translocon,SecY
MMS3_k127_971280_17	263820.PTO0664	1.98e-68	237.0	COG2019@1|root,arCOG01039@2157|Archaea,2XVK7@28890|Euryarchaeota,2426T@183967|Thermoplasmata	183967|Thermoplasmata	F	adenylate kinase activity	adkA	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AAA_17
MMS3_k127_971280_23	273116.14324569	1.578e-57	207.0	COG1422@1|root,arCOG02673@2157|Archaea,2XZDK@28890|Euryarchaeota,241UY@183967|Thermoplasmata	183967|Thermoplasmata	U	Integral membrane protein DUF106	-	-	-	-	-	-	-	-	-	-	-	-	DUF106
MMS3_k127_971280_27	673860.AciM339_1124	1.09e-48	179.0	COG1102@1|root,arCOG01037@2157|Archaea,2XWPB@28890|Euryarchaeota,3F3AN@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	Belongs to the cytidylate kinase family. Type 2 subfamily	cmk	-	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin2
MMS3_k127_971280_7	263820.PTO0667	5.154e-112	371.0	COG0130@1|root,arCOG00987@2157|Archaea,2XTUE@28890|Euryarchaeota,241NC@183967|Thermoplasmata	183967|Thermoplasmata	J	Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs	truB	-	5.4.99.25	ko:K03177,ko:K11131	ko03008,map03008	M00425	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03016,ko03032	-	-	-	PUA,TruB_C_2,TruB_N
MMS3_k127_971280_36	273075.Ta1243m	5.765e-36	147.0	COG1498@1|root,arCOG01923@2157|Archaea,2XUEA@28890|Euryarchaeota,241U5@183967|Thermoplasmata	183967|Thermoplasmata	J	snoRNA binding domain, fibrillarin	-	-	-	ko:K14564	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	Nop
MMS3_k127_971280_1	273116.14324573	1.363e-186	594.0	COG0034@1|root,arCOG00093@2157|Archaea,2XSWJ@28890|Euryarchaeota,241K9@183967|Thermoplasmata	183967|Thermoplasmata	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
MMS3_k127_971280_37	273116.14324575	9.454e-29	117.0	COG1958@1|root,arCOG00998@2157|Archaea,2Y6AG@28890|Euryarchaeota,242DM@183967|Thermoplasmata	183967|Thermoplasmata	J	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	-	-	-	ko:K04796	-	-	-	-	ko00000	-	-	-	LSM
MMS3_k127_971280_3	521098.Aaci_1457	1.892e-151	488.0	COG0183@1|root,COG0183@2|Bacteria,1TP07@1239|Firmicutes,4HASW@91061|Bacilli	91061|Bacilli	I	Belongs to the thiolase family	-	-	2.3.1.16	ko:K00632	ko00071,ko00280,ko00281,ko00362,ko00592,ko00642,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00362,map00592,map00642,map01100,map01110,map01120,map01130,map01212	M00087,M00113	R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000	-	-	-	Thiolase_C,Thiolase_N
MMS3_k127_971280_19	1288484.APCS01000050_gene197	6.463e-67	237.0	COG2897@1|root,COG2897@2|Bacteria,1WKXR@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	Sulfurtransferase	-	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
MMS3_k127_971280_33	263820.PTO0407	3.338e-43	158.0	COG1631@1|root,arCOG04109@2157|Archaea,2XXV3@28890|Euryarchaeota,241RG@183967|Thermoplasmata	183967|Thermoplasmata	J	Binds to the 23S rRNA	rpl44e	-	-	ko:K02929	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L44
MMS3_k127_971280_42	273075.Ta1204	1.926e-16	80.0	COG2051@1|root,arCOG04108@2157|Archaea,2Y6HD@28890|Euryarchaeota,241W8@183967|Thermoplasmata	183967|Thermoplasmata	J	structural constituent of ribosome	rps27e	-	-	ko:K02978	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S27e
MMS3_k127_971280_13	263820.PTO0405	1.618e-84	286.0	COG1093@1|root,arCOG04107@2157|Archaea,2XTV0@28890|Euryarchaeota,241MC@183967|Thermoplasmata	183967|Thermoplasmata	J	translation initiation factor 2 subunit alpha	eif2a	-	-	ko:K03237	ko03013,ko04138,ko04140,ko04141,ko04210,ko04932,ko05160,ko05162,ko05164,ko05168,map03013,map04138,map04140,map04141,map04210,map04932,map05160,map05162,map05164,map05168	-	-	-	ko00000,ko00001,ko03012	-	-	-	EIF_2_alpha,S1
MMS3_k127_971280_44	273075.Ta1202	2.01e-13	70.0	COG2260@1|root,arCOG00906@2157|Archaea	2157|Archaea	J	more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA	nop10	-	-	ko:K11130	ko03008,map03008	M00425	-	-	ko00000,ko00001,ko00002,ko03009,ko03032	-	-	-	Nop10p
MMS3_k127_971280_9	273116.14324627	7.453e-107	352.0	COG2047@1|root,arCOG00348@2157|Archaea,2XSX4@28890|Euryarchaeota,241Q6@183967|Thermoplasmata	183967|Thermoplasmata	S	PAC2 family	-	-	-	ko:K07159	-	-	-	-	ko00000	-	-	-	PAC2
MMS3_k127_971280_47	1449346.JQMO01000003_gene2635	0.0001785	54.0	2AARV@1|root,31047@2|Bacteria,2ICQH@201174|Actinobacteria,2M4NZ@2063|Kitasatospora	201174|Actinobacteria	S	Peptidase A4 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_A4
MMS3_k127_995906_1	105559.Nwat_1070	1.979e-86	297.0	COG4301@1|root,COG4301@2|Bacteria,1MUCG@1224|Proteobacteria,1RR44@1236|Gammaproteobacteria,1WVVH@135613|Chromatiales	135613|Chromatiales	S	Methyltransferase	-	-	2.1.1.44	ko:K18911	ko00340,map00340	-	R01169	RC00003,RC02308	ko00000,ko00001,ko01000	-	-	-	Methyltransf_33
MMS3_k127_995906_0	933115.GPDM_02615	1.65e-144	469.0	COG1262@1|root,COG1262@2|Bacteria,1TT4R@1239|Firmicutes,4HA8D@91061|Bacilli,26GER@186818|Planococcaceae	91061|Bacilli	S	Sulfatase-modifying factor enzyme 1	pkn1	-	-	-	-	-	-	-	-	-	-	-	DinB_2,FGE-sulfatase
## 1313 queries scanned
## Total time (seconds): 59.69958186149597
## Rate: 21.99 q/s