## Fri Nov 15 22:11:05 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/bin_4635/bin/bin20/PYH_1_bin.58.fa -m mmseqs --itype genome -o PYH_1_bin.58 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/4635/PYH_1_bin.58 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
PYH1_k127_1001627_0	1202532.FF52_19935	1.104e-07	61.0	COG0477@1|root,COG2814@2|Bacteria,4NFM7@976|Bacteroidetes,1HYPP@117743|Flavobacteriia,2NV9Q@237|Flavobacterium	976|Bacteroidetes	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
PYH1_k127_1002557_2	314285.KT71_03027	0.0001282	46.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1MWGR@1224|Proteobacteria,1RR88@1236|Gammaproteobacteria,1J5WK@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	EU	COG1506 Dipeptidyl aminopeptidases acylaminoacyl-peptidases	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
PYH1_k127_1002557_0	1365176.N186_05795	6.618e-194	614.0	COG1350@1|root,arCOG01432@2157|Archaea,2XQ0U@28889|Crenarchaeota	28889|Crenarchaeota	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
PYH1_k127_1002557_1	272844.PAB2084	2.787e-32	130.0	COG1142@1|root,arCOG01502@2157|Archaea,2XZWR@28890|Euryarchaeota,242V3@183968|Thermococci	183968|Thermococci	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_11,Fer4_4,Fer4_6,Fer4_9
PYH1_k127_1027470_0	1047013.AQSP01000126_gene2740	3.499e-250	797.0	COG2866@1|root,COG2866@2|Bacteria,2NQNH@2323|unclassified Bacteria	2|Bacteria	E	Zinc carboxypeptidase	-	-	-	ko:K14054	-	-	-	-	ko00000	-	-	-	AstE_AspA,Peptidase_M14
PYH1_k127_1027470_2	673860.AciM339_0044	5.877e-100	337.0	COG0162@1|root,arCOG01886@2157|Archaea,2XTA0@28890|Euryarchaeota,3F2HA@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0004832,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	tRNA-synt_1b
PYH1_k127_1027470_1	868864.Dester_1109	1.072e-122	402.0	COG0057@1|root,COG0057@2|Bacteria,2G3TK@200783|Aquificae	200783|Aquificae	C	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	gap	GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
PYH1_k127_1027470_3	693661.Arcve_0273	3.793e-80	276.0	COG0358@1|root,arCOG04281@2157|Archaea,2XTHB@28890|Euryarchaeota,245WB@183980|Archaeoglobi	183980|Archaeoglobi	L	DNA primase	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	Toprim_4
PYH1_k127_1031865_0	760568.Desku_3292	5.388e-154	502.0	COG0696@1|root,COG0696@2|Bacteria,1TPM4@1239|Firmicutes,247JG@186801|Clostridia,2602C@186807|Peptococcaceae	186801|Clostridia	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmI	-	5.4.2.12	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,Phosphodiest,iPGM_N
PYH1_k127_1044469_0	1047013.AQSP01000101_gene607	7.379e-245	768.0	COG1882@1|root,COG1882@2|Bacteria,2NQDK@2323|unclassified Bacteria	2|Bacteria	C	Pyruvate formate lyase-like	pflD	-	2.3.1.54	ko:K00656	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	-	R00212,R06987	RC00004,RC01181,RC02742,RC02833	ko00000,ko00001,ko01000	-	-	-	Gly_radical,PFL-like
PYH1_k127_1044469_2	768710.DesyoDRAFT_3843	1.104e-94	319.0	COG1180@1|root,COG1180@2|Bacteria,1TPK2@1239|Firmicutes,24871@186801|Clostridia,261PP@186807|Peptococcaceae	186801|Clostridia	C	TIGRFAM glycyl-radical enzyme activating protein family	csdA	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4,Fer4_12,Radical_SAM
PYH1_k127_1044469_1	926550.CLDAP_09850	2.82e-136	447.0	COG0477@1|root,COG2814@2|Bacteria,2G5ZW@200795|Chloroflexi	200795|Chloroflexi	EGP	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
PYH1_k127_1044469_3	529709.PYCH_14010	2.413e-15	80.0	COG1028@1|root,arCOG01259@2157|Archaea,2XTYG@28890|Euryarchaeota,245DU@183968|Thermococci	183968|Thermococci	I	KR domain	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
PYH1_k127_1076181_0	309801.trd_1557	6.624e-67	234.0	COG0174@1|root,COG0174@2|Bacteria,2G5U2@200795|Chloroflexi,27XSZ@189775|Thermomicrobia	189775|Thermomicrobia	E	glutamine synthetase	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
PYH1_k127_1076181_3	565033.GACE_1172	3.555e-13	75.0	COG3355@1|root,arCOG02242@2157|Archaea,2XY1Y@28890|Euryarchaeota,246F2@183980|Archaeoglobi	183980|Archaeoglobi	K	Sugar-specific transcriptional regulator TrmB	-	-	-	-	-	-	-	-	-	-	-	-	TrmB
PYH1_k127_1076181_1	273057.SSO2232	9.528e-31	124.0	COG0526@1|root,arCOG01972@2157|Archaea,2XQQ2@28889|Crenarchaeota	28889|Crenarchaeota	O	TIGRFAM thioredoxin	-	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
PYH1_k127_1076181_2	391623.TERMP_02150	2.765e-26	116.0	COG1906@1|root,arCOG04354@2157|Archaea,2XX2X@28890|Euryarchaeota,243P4@183968|Thermococci	183968|Thermococci	S	Protein of unknown function (DUF401)	-	-	-	ko:K09133	-	-	-	-	ko00000	-	-	-	DUF401
PYH1_k127_1077190_1	1267535.KB906767_gene3310	7.504e-07	55.0	COG2234@1|root,COG2234@2|Bacteria,3Y6K6@57723|Acidobacteria	57723|Acidobacteria	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
PYH1_k127_1077190_0	399550.Smar_1281	5.621e-89	308.0	COG1163@1|root,arCOG00358@2157|Archaea,2XPR5@28889|Crenarchaeota	28889|Crenarchaeota	S	TGS domain	-	-	-	ko:K06944	-	-	-	-	ko00000	-	-	-	MMR_HSR1,MMR_HSR1_Xtn,TGS
PYH1_k127_1077190_2	163908.KB235896_gene3079	2.346e-06	54.0	COG0346@1|root,COG0346@2|Bacteria,1G5QD@1117|Cyanobacteria,1HNHQ@1161|Nostocales	1117|Cyanobacteria	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	ko:K08234	-	-	-	-	ko00000	-	-	-	Glyoxalase
PYH1_k127_107934_2	573063.Metin_0656	1.904e-63	226.0	COG0169@1|root,arCOG01033@2157|Archaea,2XV7K@28890|Euryarchaeota,23QN8@183939|Methanococci	183939|Methanococci	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	GO:0003674,GO:0003824,GO:0004764,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0032787,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0055114,GO:0071704,GO:1901576,GO:1901615	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_DH,Shikimate_dh_N
PYH1_k127_107934_3	647113.Metok_1587	2.375e-20	99.0	COG0169@1|root,arCOG02097@2157|Archaea,2XWH4@28890|Euryarchaeota,23QHB@183939|Methanococci	183939|Methanococci	E	Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate	aroD	-	4.2.1.10	ko:K03785	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_I
PYH1_k127_107934_1	643648.Slip_0400	5.556e-89	305.0	COG0337@1|root,COG0337@2|Bacteria,1TPKZ@1239|Firmicutes,248H4@186801|Clostridia,42JQW@68298|Syntrophomonadaceae	186801|Clostridia	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	2.7.1.71,4.2.3.4	ko:K01735,ko:K13829	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412,R03083	RC00002,RC00078,RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase
PYH1_k127_107934_0	273068.TTE1013	4.229e-110	362.0	COG2876@1|root,COG2876@2|Bacteria,1TP61@1239|Firmicutes,24812@186801|Clostridia,42F9V@68295|Thermoanaerobacterales	186801|Clostridia	E	PFAM DAHP synthetase I KDSA	aroF1	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
PYH1_k127_1116127_0	453591.Igni_0637	4.186e-80	277.0	COG0519@1|root,arCOG00085@2157|Archaea,2XPVC@28889|Crenarchaeota	28889|Crenarchaeota	F	GMP synthase, glutamine-hydrolyzing	guaA	GO:0000162,GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005950,GO:0006082,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0032991,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042401,GO:0042430,GO:0042435,GO:0042451,GO:0042455,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046129,GO:0046219,GO:0046390,GO:0046394,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901657,GO:1901659,GO:1902494	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
PYH1_k127_1116127_1	1121930.AQXG01000003_gene2716	7.97e-54	197.0	COG0029@1|root,COG0029@2|Bacteria,4NGUE@976|Bacteroidetes,1IQPX@117747|Sphingobacteriia	976|Bacteroidetes	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	nadB	-	1.4.3.16	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481	RC00006,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
PYH1_k127_1117165_0	868131.MSWAN_1425	1.589e-87	299.0	COG1304@1|root,arCOG00613@2157|Archaea,2XT6H@28890|Euryarchaeota,23NQE@183925|Methanobacteria	183925|Methanobacteria	H	Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)	fni	-	5.3.3.2	ko:K01823	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00095,M00096,M00364,M00365,M00366,M00367	R01123	RC00455	ko00000,ko00001,ko00002,ko01000	-	-	-	FMN_dh
PYH1_k127_1117165_2	224719.Abm4_1229	6.569e-53	196.0	COG1608@1|root,arCOG00860@2157|Archaea,2XSUI@28890|Euryarchaeota,23NXS@183925|Methanobacteria	183925|Methanobacteria	I	Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids	-	-	2.7.4.26	ko:K06981	ko00900,ko01110,ko01130,map00900,map01110,map01130	-	R10093	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
PYH1_k127_1117165_1	1151117.AJLF01000001_gene811	2.861e-65	235.0	COG1577@1|root,arCOG01028@2157|Archaea,2XSUB@28890|Euryarchaeota,2437V@183968|Thermococci	183968|Thermococci	F	Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids	mvk	GO:0003674,GO:0003824,GO:0004496,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006084,GO:0006139,GO:0006163,GO:0006629,GO:0006637,GO:0006644,GO:0006720,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008202,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009117,GO:0009150,GO:0009240,GO:0009259,GO:0009987,GO:0016125,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019287,GO:0019637,GO:0019693,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046490,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901135,GO:1901360,GO:1901564,GO:1901576,GO:1901615	2.7.1.36	ko:K00869	ko00900,ko01100,ko01110,ko01130,ko04146,map00900,map01100,map01110,map01130,map04146	M00095	R02245	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
PYH1_k127_1117165_3	243232.MJ_0403	0.0001393	44.0	COG1355@1|root,arCOG01728@2157|Archaea,2XVYU@28890|Euryarchaeota,23QPS@183939|Methanococci	183939|Methanococci	S	Belongs to the MEMO1 family	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0032886,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0065007	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
PYH1_k127_112354_1	693661.Arcve_2092	2.474e-37	147.0	COG1418@1|root,arCOG01860@2157|Archaea,2XT54@28890|Euryarchaeota,2471D@183980|Archaeoglobi	183980|Archaeoglobi	S	PFAM Metal-dependent phosphohydrolase, HD	-	-	-	ko:K06950	-	-	-	-	ko00000	-	-	-	HD
PYH1_k127_112354_3	28583.AMAG_13600T0	2.432e-11	68.0	COG1958@1|root,KOG1783@2759|Eukaryota,3A5NM@33154|Opisthokonta,3P6ZD@4751|Fungi	4751|Fungi	A	Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway. Component of the nuclear LSM2-LSM8 complex, which is involved in splicing of nuclear mRNAs. LSM2-LSM8 associates with multiple snRNP complexes containing the U6 snRNA (U4 U6 di-snRNP, spliceosomal U4 U6.U5 tri-snRNP, and free U6 snRNP). It binds directly to the 3'-terminal U-tract of U6 snRNA and plays a role in the biogenesis and stability of the U6 snRNP and U4 U6 snRNP complexes. LSM2-LSM8 probably also is involved degradation of nuclear pre-mRNA by targeting them for decapping, and in processing of pre-tRNAs, pre-rRNAs and U3 snoRNA (By similarity)	LSM6	GO:0000375,GO:0000377,GO:0000398,GO:0000932,GO:0003674,GO:0003676,GO:0003723,GO:0003727,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005688,GO:0005730,GO:0005732,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008187,GO:0008266,GO:0008380,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016072,GO:0022613,GO:0030490,GO:0030532,GO:0031974,GO:0031981,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0035770,GO:0036464,GO:0042254,GO:0042274,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044085,GO:0044237,GO:0044238,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0045292,GO:0046483,GO:0046540,GO:0070013,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097525,GO:0097526,GO:0120114,GO:0120115,GO:1901360,GO:1901363,GO:1990726,GO:1990904	-	ko:K12625	ko03018,ko03040,map03018,map03040	M00354,M00396,M00397	-	-	ko00000,ko00001,ko00002,ko03019,ko03041	-	-	-	LSM
PYH1_k127_112354_2	1056495.Calag_0219	9.683e-15	81.0	COG0500@1|root,arCOG03773@2157|Archaea,2XR9G@28889|Crenarchaeota	28889|Crenarchaeota	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
PYH1_k127_112354_0	192952.MM_0259	1.224e-190	609.0	COG0129@1|root,arCOG04045@2157|Archaea,2XSW2@28890|Euryarchaeota,2N992@224756|Methanomicrobia	224756|Methanomicrobia	E	Belongs to the IlvD Edd family	ilvD	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A2069	ILVD_EDD
PYH1_k127_1136005_0	388413.ALPR1_15949	2.155e-31	132.0	COG1215@1|root,COG1215@2|Bacteria,4NEK9@976|Bacteroidetes,47MJK@768503|Cytophagia	976|Bacteroidetes	M	glycosyl transferase family 2	-	-	-	ko:K00786	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_tranf_2_3
PYH1_k127_115751_0	756883.Halar_3645	6.559e-71	244.0	COG1506@1|root,arCOG01646@2157|Archaea	2157|Archaea	E	Peptidase S9 prolyl oligopeptidase active site	pop	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9,Peptidase_S9_N
PYH1_k127_115751_1	221288.JH992901_gene4794	1.389e-52	194.0	COG0500@1|root,COG0500@2|Bacteria,1G237@1117|Cyanobacteria,1JKTR@1189|Stigonemataceae	1117|Cyanobacteria	Q	Ribosomal RNA adenine dimethylase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
PYH1_k127_115751_2	388051.AUFE01000004_gene792	2.178e-52	199.0	COG2355@1|root,COG2355@2|Bacteria,1MWEW@1224|Proteobacteria,2VP9R@28216|Betaproteobacteria,1KFNK@119060|Burkholderiaceae	28216|Betaproteobacteria	E	PFAM peptidase M19 renal dipeptidase	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
PYH1_k127_118594_1	525904.Tter_0984	3.386e-14	77.0	COG3118@1|root,COG3118@2|Bacteria,2NPNZ@2323|unclassified Bacteria	2|Bacteria	O	Belongs to the thioredoxin family	trxA	-	-	ko:K03671,ko:K05838	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	iIT341.HP0824	TPR_16,TPR_19,Thioredoxin
PYH1_k127_118594_0	391623.TERMP_00735	6.011e-25	113.0	COG2512@1|root,arCOG00374@2157|Archaea,2Y30F@28890|Euryarchaeota,243E6@183968|Thermococci	183968|Thermococci	K	Sugar-specific transcriptional regulator TrmB	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24,TrmB
PYH1_k127_1224758_1	580327.Tthe_1040	6.636e-17	87.0	COG1247@1|root,COG1247@2|Bacteria,1UHYR@1239|Firmicutes,24H0A@186801|Clostridia,42G6C@68295|Thermoanaerobacterales	186801|Clostridia	M	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
PYH1_k127_1224758_0	1449126.JQKL01000063_gene2295	6.631e-54	204.0	COG4948@1|root,COG4948@2|Bacteria,1TS0S@1239|Firmicutes,24AE7@186801|Clostridia	186801|Clostridia	M	Mandelate racemase muconate lactonizing enzyme	-	-	4.2.1.5	ko:K01683	-	-	-	-	ko00000,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
PYH1_k127_1232945_3	1094508.Tsac_1090	1.558e-10	63.0	COG1011@1|root,COG1011@2|Bacteria	2|Bacteria	S	phosphatase activity	-	-	3.1.3.5	ko:K07025,ko:K08723	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
PYH1_k127_1232945_2	1042877.GQS_04200	2.137e-41	165.0	arCOG11292@1|root,arCOG11292@2157|Archaea,2Y3FT@28890|Euryarchaeota,2443S@183968|Thermococci	183968|Thermococci	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_1232945_0	1347392.CCEZ01000075_gene3081	2.399e-98	340.0	COG1574@1|root,COG1574@2|Bacteria,1TQ6G@1239|Firmicutes,24A5F@186801|Clostridia,36DJ1@31979|Clostridiaceae	186801|Clostridia	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
PYH1_k127_1232945_4	565655.ECBG_00077	0.0001088	45.0	COG0546@1|root,COG0546@2|Bacteria,1TPPZ@1239|Firmicutes,4HE7X@91061|Bacilli	91061|Bacilli	S	Hydrolyzes pyrophosphate formed during P-Ser-HPr dephosphorylation by HPrK P. Might play a role in controlling the intracellular pyrophosphate pool	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
PYH1_k127_1233712_0	1134413.ANNK01000092_gene176	3.575e-59	207.0	COG0388@1|root,COG0388@2|Bacteria,1TQR9@1239|Firmicutes,4HDUI@91061|Bacilli,1ZBD0@1386|Bacillus	91061|Bacilli	S	Carbon-nitrogen hydrolase	-	-	3.5.5.1	ko:K01501	ko00380,ko00460,ko00627,ko00643,ko00910,ko01120,map00380,map00460,map00627,map00643,map00910,map01120	-	R00540,R01887,R03093,R03542,R05591,R07855	RC00315,RC00325,RC00617,RC00959,RC02811	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase
PYH1_k127_1233712_1	529709.PYCH_01970	1.946e-29	123.0	arCOG04797@1|root,arCOG04797@2157|Archaea,2XZMY@28890|Euryarchaeota,24531@183968|Thermococci	183968|Thermococci	S	retrograde transport, endosome to Golgi	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_1233712_2	742735.HMPREF9467_04809	1.311e-06	56.0	COG1657@1|root,COG1657@2|Bacteria,1TPY3@1239|Firmicutes,247MQ@186801|Clostridia,21ZP1@1506553|Lachnoclostridium	186801|Clostridia	I	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_127422_0	694429.Pyrfu_0975	2.692e-182	578.0	COG0365@1|root,arCOG01529@2157|Archaea,2XPY4@28889|Crenarchaeota	28889|Crenarchaeota	I	synthetase	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
PYH1_k127_127422_2	386456.JQKN01000002_gene2682	1.04e-157	512.0	COG0119@1|root,arCOG02092@2157|Archaea,2XSZJ@28890|Euryarchaeota,23NNQ@183925|Methanobacteria	183925|Methanobacteria	E	Catalyzes the condensation of pyruvate and acetyl- coenzyme A to form (R)-citramalate	cimA	-	2.3.1.182	ko:K09011	ko00290,ko00660,ko01100,ko01210,ko01230,map00290,map00660,map01100,map01210,map01230	M00535	R07399	RC00004,RC01205	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
PYH1_k127_127422_1	868131.MSWAN_2314	5.104e-160	514.0	COG0065@1|root,arCOG01698@2157|Archaea,2XTWH@28890|Euryarchaeota,23PD9@183925|Methanobacteria	183925|Methanobacteria	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
PYH1_k127_127422_4	1158345.JNLL01000001_gene1438	4.689e-57	203.0	COG0066@1|root,COG0066@2|Bacteria,2G405@200783|Aquificae	200783|Aquificae	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
PYH1_k127_127422_3	386456.JQKN01000010_gene710	3.493e-106	353.0	COG0473@1|root,arCOG01163@2157|Archaea,2XT99@28890|Euryarchaeota,23NNW@183925|Methanobacteria	183925|Methanobacteria	C	Isocitrate isopropylmalate dehydrogenase	leuB	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
PYH1_k127_1284034_1	386456.JQKN01000001_gene2369	1.535e-59	209.0	COG1839@1|root,arCOG04298@2157|Archaea,2XY40@28890|Euryarchaeota	28890|Euryarchaeota	L	PFAM Adenosine specific kinase	-	-	-	ko:K09129	-	-	-	-	ko00000	-	-	-	Adenosine_kin
PYH1_k127_1284034_2	933801.Ahos_1184	1.47e-44	169.0	COG0500@1|root,arCOG01631@2157|Archaea,2XQ7P@28889|Crenarchaeota	28889|Crenarchaeota	Q	RNA methylase	-	GO:0003674,GO:0003824,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016278,GO:0016279,GO:0016740,GO:0016741,GO:0018022,GO:0018193,GO:0018205,GO:0019538,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:0140096,GO:1901564	-	-	-	-	-	-	-	-	-	-	CMAS,DOT1,Methyltransf_25,Methyltransf_31,PrmA
PYH1_k127_1284034_0	1343739.PAP_09660	8.799e-102	339.0	COG0540@1|root,arCOG00911@2157|Archaea,2XSZ7@28890|Euryarchaeota,242WA@183968|Thermococci	183968|Thermococci	F	Aspartate carbamoyltransferase	pyrB	GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
PYH1_k127_1284034_3	56780.SYN_01018	1.436e-31	128.0	COG1051@1|root,COG1051@2|Bacteria,1MWNH@1224|Proteobacteria,42T59@68525|delta/epsilon subdivisions,2WPMV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Belongs to the Nudix hydrolase family	-	-	3.6.1.13,3.6.1.55	ko:K01515,ko:K03574	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000,ko03400	-	-	-	NUDIX
PYH1_k127_1284034_4	693661.Arcve_1505	5.646e-11	70.0	COG0433@1|root,arCOG00280@2157|Archaea,2Y7MA@28890|Euryarchaeota,246V1@183980|Archaeoglobi	183980|Archaeoglobi	L	AAA-like domain	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF87,HAS-barrel
PYH1_k127_1292333_0	698757.Pogu_0392	1.709e-72	260.0	COG1746@1|root,arCOG04249@2157|Archaea,2XQ3X@28889|Crenarchaeota	28889|Crenarchaeota	J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate	cca	-	2.7.7.72	ko:K07558	-	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko01000,ko03016	-	-	-	NTP_transf_2,tRNA_NucTransf2
PYH1_k127_1292333_1	1229909.NSED_09550	1.434e-53	197.0	COG2112@1|root,arCOG01182@2157|Archaea,41SJV@651137|Thaumarchaeota	651137|Thaumarchaeota	T	Ser thr protein kinase	-	-	-	ko:K07176	-	-	-	-	ko00000	-	-	-	RIO1
PYH1_k127_1293715_5	1229909.NSED_09580	9.088e-09	59.0	COG1711@1|root,arCOG00551@2157|Archaea,41SVQ@651137|Thaumarchaeota	651137|Thaumarchaeota	L	protein conserved in archaea	-	-	-	ko:K09723	-	-	-	-	ko00000,ko03032	-	-	-	-
PYH1_k127_1293715_1	768672.Desfe_0899	1.57e-26	111.0	COG1631@1|root,arCOG04109@2157|Archaea,2XQU0@28889|Crenarchaeota	28889|Crenarchaeota	J	binds to the 23S rRNA	rpl44e	-	-	ko:K02929	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L44
PYH1_k127_1293715_3	768679.TTX_0576	1.395e-15	78.0	COG2051@1|root,arCOG04108@2157|Archaea,2XR0Y@28889|Crenarchaeota	28889|Crenarchaeota	J	PFAM ribosomal protein	rps27e	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02978	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S27e
PYH1_k127_1293715_0	1042877.GQS_04040	2.349e-54	200.0	COG1093@1|root,arCOG04107@2157|Archaea,2XTV0@28890|Euryarchaeota,243FV@183968|Thermococci	183968|Thermococci	J	eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA	eif2a	GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K03237	ko03013,ko04138,ko04140,ko04141,ko04210,ko04932,ko05160,ko05162,ko05164,ko05168,map03013,map04138,map04140,map04141,map04210,map04932,map05160,map05162,map05164,map05168	-	-	-	ko00000,ko00001,ko03012	-	-	-	EIF_2_alpha,S1
PYH1_k127_1293715_4	178306.PAE3031	1.114e-14	75.0	COG2260@1|root,arCOG00906@2157|Archaea,2XR3J@28889|Crenarchaeota	28889|Crenarchaeota	J	more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA	nop10	-	-	ko:K11130	ko03008,map03008	M00425	-	-	ko00000,ko00001,ko00002,ko03009,ko03032	-	-	-	Nop10p
PYH1_k127_1293715_2	373903.Hore_22490	2.477e-22	96.0	COG1773@1|root,COG1773@2|Bacteria,1VEQC@1239|Firmicutes,24QUV@186801|Clostridia,3WC7H@53433|Halanaerobiales	186801|Clostridia	C	PFAM Rubredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Rubredoxin
PYH1_k127_131375_1	411902.CLOBOL_06444	6.029e-14	77.0	COG1168@1|root,COG1168@2|Bacteria,1TP5G@1239|Firmicutes,24YUP@186801|Clostridia,21Y0J@1506553|Lachnoclostridium	186801|Clostridia	E	Aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
PYH1_k127_131375_0	1009370.ALO_02171	2.127e-111	375.0	COG1473@1|root,COG1473@2|Bacteria,1TQ7B@1239|Firmicutes,4H2ZX@909932|Negativicutes	909932|Negativicutes	S	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
PYH1_k127_134779_0	926569.ANT_19770	1.385e-45	171.0	COG1073@1|root,COG1073@2|Bacteria,2G690@200795|Chloroflexi	200795|Chloroflexi	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_5
PYH1_k127_134779_1	1042877.GQS_05375	1.131e-24	114.0	COG0382@1|root,arCOG00476@2157|Archaea,2XUHS@28890|Euryarchaeota,242VX@183968|Thermococci	183968|Thermococci	H	Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids	ubiA	-	2.5.1.42	ko:K17105	ko00564,map00564	-	R04520	RC01171	ko00000,ko00001,ko01000	-	-	-	UbiA
PYH1_k127_1412229_2	1235800.C819_04061	3.603e-09	64.0	COG0500@1|root,COG2226@2|Bacteria,1TSBS@1239|Firmicutes,253MR@186801|Clostridia	186801|Clostridia	Q	Mycolic acid cyclopropane synthetase	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_1412229_0	1502851.FG93_04466	8.333e-36	139.0	COG0346@1|root,COG0346@2|Bacteria,1RIW7@1224|Proteobacteria,2U9Y8@28211|Alphaproteobacteria,3K4A7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
PYH1_k127_1412229_1	1156935.QWE_15301	3.328e-23	103.0	COG0346@1|root,COG0346@2|Bacteria,1RIW7@1224|Proteobacteria,2U9Y8@28211|Alphaproteobacteria,4BEFM@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
PYH1_k127_150295_1	1365176.N186_03050	2.106e-93	318.0	COG0043@1|root,arCOG01671@2157|Archaea,2XPU8@28889|Crenarchaeota	28889|Crenarchaeota	H	TIGRFAM UbiD family	-	-	-	-	-	-	-	-	-	-	-	-	UbiD
PYH1_k127_150295_0	573063.Metin_0709	3.374e-119	394.0	COG1679@1|root,arCOG04278@2157|Archaea,2XTY6@28890|Euryarchaeota,23QFZ@183939|Methanococci	183939|Methanococci	S	Protein of unknown function (DUF521)	-	-	-	ko:K09123	-	-	-	-	ko00000	-	-	-	DUF521
PYH1_k127_150295_2	868131.MSWAN_0095	6.413e-42	158.0	COG1786@1|root,arCOG04279@2157|Archaea,2XYXJ@28890|Euryarchaeota,23P5Y@183925|Methanobacteria	183925|Methanobacteria	C	Belongs to the UPF0107 family	-	-	-	ko:K09128	-	-	-	-	ko00000	-	-	-	DUF126
PYH1_k127_1540509_1	279010.BL02514	5.704e-53	193.0	COG2039@1|root,COG2039@2|Bacteria,1TRRX@1239|Firmicutes,4HCIJ@91061|Bacilli,1ZEI9@1386|Bacillus	91061|Bacilli	O	Removes 5-oxoproline from various penultimate amino acid residues except L-proline	pcp	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0071704,GO:1901564	3.4.19.3	ko:K01304	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_C15
PYH1_k127_1540509_2	386456.JQKN01000001_gene2010	1.134e-33	135.0	COG1986@1|root,arCOG01223@2157|Archaea,2XWGY@28890|Euryarchaeota,23P4J@183925|Methanobacteria	183925|Methanobacteria	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	-	2.7.7.3	ko:K02201	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
PYH1_k127_1540509_0	1365176.N186_07630	2.525e-91	314.0	COG1055@1|root,arCOG00238@2157|Archaea,2XQX1@28889|Crenarchaeota	28889|Crenarchaeota	P	Sodium:sulfate symporter transmembrane region	-	-	-	ko:K11106,ko:K14445	-	-	-	-	ko00000,ko02000	2.A.47.1,2.A.47.3.3	-	-	Na_sulph_symp
PYH1_k127_1545795_0	1459636.NTE_01473	4.09e-107	355.0	COG1405@1|root,arCOG01981@2157|Archaea,41SXZ@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	-	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
PYH1_k127_1545795_2	1459636.NTE_00649	1.209e-50	194.0	COG2237@1|root,arCOG04151@2157|Archaea,41SA3@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Domain of unknown function (DUF373)	-	-	-	ko:K08975	-	-	-	-	ko00000	-	-	-	DUF373
PYH1_k127_1545795_1	573064.Mefer_0013	6.123e-89	300.0	COG0020@1|root,arCOG01532@2157|Archaea,2XSW1@28890|Euryarchaeota,23Q8C@183939|Methanococci	183939|Methanococci	H	Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids	uppS	GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617	2.5.1.89	ko:K15888	ko00900,map00900	-	R09730	RC00279,RC02839	ko00000,ko00001,ko01000	-	-	-	Prenyltransf
PYH1_k127_1549742_0	386456.JQKN01000001_gene1782	2.722e-67	246.0	COG1032@1|root,arCOG01356@2157|Archaea,2XU04@28890|Euryarchaeota	28890|Euryarchaeota	C	SMART Elongator protein 3 MiaB NifB	-	-	1.21.98.3	ko:K04034	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R06268,R06269,R06270	RC00741,RC01491,RC01492	ko00000,ko00001,ko01000	-	-	-	B12-binding,Radical_SAM
PYH1_k127_1549742_1	350688.Clos_0876	1.259e-66	242.0	COG1804@1|root,COG1804@2|Bacteria,1TP54@1239|Firmicutes,24AFB@186801|Clostridia,36FMV@31979|Clostridiaceae	186801|Clostridia	C	PFAM L-carnitine dehydratase bile acid-inducible protein F	-	-	2.8.3.16,2.8.3.19	ko:K07749,ko:K18702	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
PYH1_k127_1563799_1	237368.SCABRO_03312	3.352e-52	195.0	COG2379@1|root,COG2379@2|Bacteria,2IXJ2@203682|Planctomycetes	203682|Planctomycetes	G	MOFRL family	-	-	2.7.1.165	ko:K11529	ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200	M00346	R08572	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4147,MOFRL
PYH1_k127_1563799_0	399550.Smar_0866	9.153e-266	837.0	COG0480@1|root,arCOG01559@2157|Archaea,2XPV5@28889|Crenarchaeota	28889|Crenarchaeota	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03234	ko04152,ko04921,map04152,map04921	-	-	-	ko00000,ko00001,ko03012,ko04147	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
PYH1_k127_1563799_2	1227487.C474_21261	1.833e-42	169.0	COG0704@1|root,arCOG00318@2157|Archaea,2XT7D@28890|Euryarchaeota,23SX0@183963|Halobacteria	183963|Halobacteria	K	Phosphate uptake regulator	phoU5	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin,PhoU
PYH1_k127_1586691_0	1365176.N186_05120	2.503e-89	304.0	COG1793@1|root,arCOG01347@2157|Archaea,2XPV8@28889|Crenarchaeota	28889|Crenarchaeota	L	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair	lig	GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016874,GO:0016886,GO:0022616,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360,GO:1901576	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N
PYH1_k127_159460_0	1365176.N186_09630	5.609e-68	239.0	COG0683@1|root,arCOG01021@2157|Archaea,2XQA8@28889|Crenarchaeota	28889|Crenarchaeota	E	PFAM Extracellular ligand-binding receptor	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
PYH1_k127_1597253_1	1123376.AUIU01000012_gene1404	1.855e-73	260.0	COG1902@1|root,COG1902@2|Bacteria,3J14N@40117|Nitrospirae	40117|Nitrospirae	C	NADH:flavin oxidoreductase / NADH oxidase family	-	-	-	ko:K10680	ko00633,ko01120,map00633,map01120	-	R08014,R08017,R08042	RC00250	ko00000,ko00001,ko01000	-	-	-	Oxidored_FMN
PYH1_k127_1597253_0	1209989.TepiRe1_0729	1.518e-165	538.0	COG0441@1|root,COG0441@2|Bacteria,1TP78@1239|Firmicutes,248CH@186801|Clostridia,42EQA@68295|Thermoanaerobacterales	186801|Clostridia	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
PYH1_k127_1597253_3	1292035.H476_1048	6.149e-56	206.0	2BYY4@1|root,2Z80Y@2|Bacteria,1TSXF@1239|Firmicutes,24B6G@186801|Clostridia,25T1J@186804|Peptostreptococcaceae	186801|Clostridia	S	Domain of unknown function (DUF4438)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4438
PYH1_k127_1597253_2	373903.Hore_08360	1.172e-65	234.0	2BYY4@1|root,2Z80Y@2|Bacteria,1TSXF@1239|Firmicutes,24B6G@186801|Clostridia	186801|Clostridia	S	Domain of unknown function (DUF4438)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4438
PYH1_k127_1597253_5	650150.ERH_0536	2.551e-10	67.0	COG0317@1|root,COG0317@2|Bacteria,1TNYZ@1239|Firmicutes,3VNQ1@526524|Erysipelotrichia	526524|Erysipelotrichia	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	-	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
PYH1_k127_1597253_4	697281.Mahau_0930	2.709e-19	92.0	COG0317@1|root,COG0317@2|Bacteria,1TNYZ@1239|Firmicutes,2489A@186801|Clostridia,42F3U@68295|Thermoanaerobacterales	186801|Clostridia	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS16615	ACT_4,HD_4,RelA_SpoT,TGS
PYH1_k127_1604003_2	351627.Csac_2240	5.766e-13	71.0	COG0703@1|root,COG0703@2|Bacteria,1VA6Z@1239|Firmicutes,24MQY@186801|Clostridia,42GWP@68295|Thermoanaerobacterales	186801|Clostridia	F	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	aroK	-	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CM_2,SKI
PYH1_k127_1604003_1	552811.Dehly_0220	1.068e-93	322.0	COG0128@1|root,COG0128@2|Bacteria,2G6S6@200795|Chloroflexi,34CNP@301297|Dehalococcoidia	301297|Dehalococcoidia	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
PYH1_k127_1604003_0	1459636.NTE_01951	2.161e-131	428.0	COG0082@1|root,arCOG04133@2157|Archaea,41SC3@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	-	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
PYH1_k127_1609502_1	91464.S7335_589	3.844e-34	141.0	COG0596@1|root,COG0596@2|Bacteria,1GFX0@1117|Cyanobacteria	1117|Cyanobacteria	S	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
PYH1_k127_1609502_0	861299.J421_1115	6.833e-45	174.0	COG0457@1|root,COG0457@2|Bacteria,1ZTCW@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_1610356_0	395493.BegalDRAFT_1071	5.442e-66	244.0	COG2989@1|root,COG2989@2|Bacteria,1MV14@1224|Proteobacteria,1RQR7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	protein conserved in bacteria	ycbB	-	-	ko:K21470	-	-	-	-	ko00000,ko01002,ko01011	-	-	-	PG_binding_1,YkuD
PYH1_k127_1610356_1	1191523.MROS_0520	1.853e-14	73.0	COG2911@1|root,COG2911@2|Bacteria	2|Bacteria	S	protein secretion	-	-	-	ko:K15125	ko05133,map05133	-	-	-	ko00000,ko00001,ko00536	-	-	-	Porin_2
PYH1_k127_1615058_0	70601.3256702	7.435e-202	645.0	COG1274@1|root,arCOG05865@2157|Archaea,2XUU1@28890|Euryarchaeota,24380@183968|Thermococci	183968|Thermococci	C	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle	pckG	-	4.1.1.32	ko:K01596	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964	M00003	R00431,R00726	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_C,PEPCK_N
PYH1_k127_1618138_0	573413.Spirs_2850	1.269e-197	637.0	COG0243@1|root,COG0243@2|Bacteria,2J9ZG@203691|Spirochaetes	203691|Spirochaetes	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.8.5.3	ko:K07306	ko00920,map00920	-	R09501	RC02555	ko00000,ko00001,ko01000,ko02000	5.A.3.3	-	-	Molybdopterin,Molydop_binding,Nitrate_red_del
PYH1_k127_1634259_0	871963.Desdi_0385	3.586e-52	189.0	COG0778@1|root,COG0778@2|Bacteria,1V80D@1239|Firmicutes,24I9R@186801|Clostridia,262GW@186807|Peptococcaceae	186801|Clostridia	C	PFAM Nitroreductase family	noxC	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase,TM1586_NiRdase
PYH1_k127_1634259_1	553973.CLOHYLEM_07216	1.947e-37	151.0	COG1402@1|root,COG1402@2|Bacteria,1V0N8@1239|Firmicutes,24R48@186801|Clostridia,22448@1506553|Lachnoclostridium	186801|Clostridia	S	Creatinine amidohydrolase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
PYH1_k127_1634259_2	272557.APE_1044	1.156e-16	88.0	COG0778@1|root,arCOG00288@2157|Archaea,2XQJA@28889|Crenarchaeota	28889|Crenarchaeota	C	PFAM Nitroreductase	-	-	1.13.11.79	ko:K04719	ko00740,ko01100,map00740,map01100	-	R09083	RC00435,RC02413	ko00000,ko00001,ko01000	-	-	-	Nitroreductase
PYH1_k127_1641954_0	35841.BT1A1_0424	5.325e-123	402.0	COG0137@1|root,COG0137@2|Bacteria,1TP3X@1239|Firmicutes,4HA1E@91061|Bacilli,1ZC1P@1386|Bacillus	91061|Bacilli	E	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iSB619.SA_RS04675	Arginosuc_synth
PYH1_k127_1641954_1	1391646.AVSU01000057_gene1260	7.378e-36	141.0	COG0285@1|root,COG0285@2|Bacteria,1TPX5@1239|Firmicutes,247PC@186801|Clostridia,25QCF@186804|Peptostreptococcaceae	186801|Clostridia	H	Folylpolyglutamate synthase	folC	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M
PYH1_k127_1647117_5	373903.Hore_03410	5.474e-28	118.0	COG3285@1|root,COG3285@2|Bacteria,1TSAC@1239|Firmicutes,24BRE@186801|Clostridia	186801|Clostridia	L	DNA polymerase LigD, polymerase domain	ligD1	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
PYH1_k127_1647117_3	1268635.Loa_02542	5.093e-46	176.0	COG1273@1|root,COG1273@2|Bacteria,1N4UX@1224|Proteobacteria,1RNJ7@1236|Gammaproteobacteria,1JE57@118969|Legionellales	118969|Legionellales	L	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD	ku	-	-	ko:K10979	ko03450,map03450	-	-	-	ko00000,ko00001,ko03400	-	-	-	Ku
PYH1_k127_1647117_2	1232429.CBLL010000135_gene1197	9.946e-49	192.0	COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria,2GJPX@201174|Actinobacteria,1W81P@1268|Micrococcaceae	201174|Actinobacteria	L	DNA polymerase Ligase (LigD)	ligD	GO:0000166,GO:0000287,GO:0000726,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0003896,GO:0003899,GO:0003909,GO:0003910,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0004652,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006269,GO:0006281,GO:0006302,GO:0006303,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0008296,GO:0008297,GO:0008310,GO:0008408,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016874,GO:0016886,GO:0016895,GO:0017076,GO:0018130,GO:0019438,GO:0030145,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0033554,GO:0034061,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0070566,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0097159,GO:0097367,GO:0097747,GO:0140097,GO:0140098,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576	6.5.1.1,6.5.1.6,6.5.1.7	ko:K01971,ko:K10747	ko03030,ko03410,ko03420,ko03430,ko03450,map03030,map03410,map03420,map03430,map03450	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
PYH1_k127_1647117_4	685727.REQ_10780	1.105e-42	174.0	COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria,2GJPX@201174|Actinobacteria,4FVM6@85025|Nocardiaceae	201174|Actinobacteria	L	DNA polymerase Ligase (LigD)	ligD	GO:0000166,GO:0000287,GO:0000726,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0003896,GO:0003899,GO:0003909,GO:0003910,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0004652,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006269,GO:0006281,GO:0006302,GO:0006303,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0008296,GO:0008297,GO:0008310,GO:0008408,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016874,GO:0016886,GO:0016895,GO:0017076,GO:0018130,GO:0019438,GO:0030145,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0033554,GO:0034061,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0070566,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0097159,GO:0097367,GO:0097747,GO:0140097,GO:0140098,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576	6.5.1.1,6.5.1.6,6.5.1.7	ko:K01971,ko:K10747	ko03030,ko03410,ko03420,ko03430,ko03450,map03030,map03410,map03420,map03430,map03450	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
PYH1_k127_1647117_1	323259.Mhun_1562	6.054e-95	316.0	COG4912@1|root,arCOG05122@2157|Archaea,2XWYV@28890|Euryarchaeota,2N9IE@224756|Methanomicrobia	224756|Methanomicrobia	L	PFAM DNA alkylation repair enzyme	-	-	-	-	-	-	-	-	-	-	-	-	DNA_alkylation
PYH1_k127_1647117_0	479434.Sthe_1925	7.481e-140	462.0	COG1574@1|root,COG1574@2|Bacteria,2G5YJ@200795|Chloroflexi,27YWM@189775|Thermomicrobia	189775|Thermomicrobia	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
PYH1_k127_1647117_6	871963.Desdi_1495	1.261e-15	79.0	COG1053@1|root,COG1053@2|Bacteria,1TRE8@1239|Firmicutes,247TH@186801|Clostridia,261C3@186807|Peptococcaceae	186801|Clostridia	C	Succinate dehydrogenase fumarate reductase flavoprotein	-	-	1.8.99.2	ko:K00394	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00596	R00860,R04927,R08553	RC00007,RC01239,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
PYH1_k127_1660933_5	1379698.RBG1_1C00001G0115	7.231e-24	111.0	28MEN@1|root,2ZASA@2|Bacteria,2NQD3@2323|unclassified Bacteria	2|Bacteria	S	Evidence 5 No homology to any previously reported sequences	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_1660933_0	247490.KSU1_B0657	4.896e-198	634.0	COG1070@1|root,COG1070@2|Bacteria,2IY9E@203682|Planctomycetes	203682|Planctomycetes	G	MutL protein	-	-	-	-	-	-	-	-	-	-	-	-	MutL
PYH1_k127_1660933_1	1379698.RBG1_1C00001G0120	4.363e-100	338.0	28II6@1|root,2Z8JB@2|Bacteria,2NNT1@2323|unclassified Bacteria	2|Bacteria	S	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_1660933_4	304371.MCP_2611	2.884e-47	180.0	COG1014@1|root,arCOG01603@2157|Archaea,2XVFR@28890|Euryarchaeota,2N9J1@224756|Methanomicrobia	224756|Methanomicrobia	C	TIGRFAM pyruvate ketoisovalerate oxidoreductase, gamma subunit	porC-1	-	1.2.7.1	ko:K00172	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
PYH1_k127_1660933_6	384616.Pisl_0498	2.701e-16	89.0	COG1144@1|root,arCOG01605@2157|Archaea,2XQW3@28889|Crenarchaeota	28889|Crenarchaeota	C	TIGRFAM pyruvate ferredoxin flavodoxin oxidoreductase, delta subunit	-	-	1.2.7.1	ko:K00171	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4
PYH1_k127_1660933_2	1121468.AUBR01000064_gene940	1.255e-70	253.0	COG0674@1|root,COG0674@2|Bacteria,1VS48@1239|Firmicutes,25E5U@186801|Clostridia,42EUF@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein	porA	-	1.2.7.1	ko:K00169	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
PYH1_k127_1660933_3	439481.Aboo_0301	1.543e-65	234.0	COG1013@1|root,arCOG01601@2157|Archaea,2XT3E@28890|Euryarchaeota,3F2JH@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	vorB	-	1.2.7.1,1.2.7.7	ko:K00170,ko:K00187	ko00010,ko00020,ko00280,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00280,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R07160,R08034,R08566,R08567	RC00004,RC00250,RC02742,RC02833,RC02856	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
PYH1_k127_1663206_3	1131266.ARWQ01000005_gene840	2.207e-21	96.0	COG0541@1|root,arCOG01228@2157|Archaea,41SDP@651137|Thaumarchaeota	651137|Thaumarchaeota	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	srp54	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
PYH1_k127_1663206_4	1041930.Mtc_2248	7.484e-21	94.0	COG2139@1|root,arCOG04129@2157|Archaea,2XXZB@28890|Euryarchaeota,2N9X1@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the eukaryotic ribosomal protein eL21 family	rpl21e	-	-	ko:K02889	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21e
PYH1_k127_1663206_6	1365176.N186_02780	1.26e-05	52.0	COG1460@1|root,arCOG01016@2157|Archaea,2XRD2@28889|Crenarchaeota	28889|Crenarchaeota	K	PFAM RNA polymerase Rpb4	rpoF	-	2.7.7.6	ko:K03051	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb4
PYH1_k127_1663206_1	70601.3258258	3.422e-51	187.0	COG1491@1|root,arCOG04130@2157|Archaea,2XXAI@28890|Euryarchaeota,242KI@183968|Thermococci	183968|Thermococci	J	Protein of unknown function (DUF655)	-	-	-	ko:K07572	-	-	-	-	ko00000	-	-	-	DUF655
PYH1_k127_1663206_2	243232.MJ_0543	1.545e-39	153.0	COG0197@1|root,arCOG04113@2157|Archaea,2XTHT@28890|Euryarchaeota,23QNQ@183939|Methanococci	183939|Methanococci	J	Belongs to the universal ribosomal protein uL16 family	rpl10e	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02866	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
PYH1_k127_1663206_0	1220534.B655_2059	1.751e-66	239.0	COG1736@1|root,arCOG04112@2157|Archaea,2XSY5@28890|Euryarchaeota,23NUP@183925|Methanobacteria	183925|Methanobacteria	J	Diphthamide	-	-	2.5.1.108	ko:K07561	-	-	R10455	RC00021,RC03180	ko00000,ko01000,ko03012	-	-	-	Diphthamide_syn
PYH1_k127_1663206_5	246969.TAM4_606	3.696e-18	91.0	COG1096@1|root,arCOG00676@2157|Archaea,2XYYA@28890|Euryarchaeota,243T0@183968|Thermococci	183968|Thermococci	J	Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs	csl4	-	-	ko:K07573	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	ECR1_N,EXOSC1
PYH1_k127_1679355_0	694429.Pyrfu_0043	1.511e-43	165.0	COG0237@1|root,arCOG01045@2157|Archaea,2XQTJ@28889|Crenarchaeota	28889|Crenarchaeota	F	Belongs to the UPF0200 family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_17,AAA_18
PYH1_k127_1679355_2	698757.Pogu_0137	5.706e-10	65.0	COG1931@1|root,arCOG01043@2157|Archaea,2XQU6@28889|Crenarchaeota	28889|Crenarchaeota	S	Belongs to the UPF0201 family	-	-	-	ko:K09736	-	-	-	-	ko00000	-	-	-	RNA_binding
PYH1_k127_1679355_1	439481.Aboo_0959	2.569e-36	143.0	COG0446@1|root,arCOG01069@2157|Archaea,2XT0A@28890|Euryarchaeota,3F2PD@33867|unclassified Euryarchaeota	28890|Euryarchaeota	P	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	ndh	-	1.6.3.3,1.6.99.3	ko:K03885,ko:K17870	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
PYH1_k127_1681918_1	591019.Shell_0007	4.539e-31	129.0	COG1936@1|root,arCOG01038@2157|Archaea,2XQII@28889|Crenarchaeota	28889|Crenarchaeota	F	Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates	-	-	2.7.4.3	ko:K18532	ko00230,ko01100,ko01110,ko01130,ko03008,map00230,map01100,map01110,map01130,map03008	M00049	R00127,R01547	RC00002	ko00000,ko00001,ko00002,ko01000,ko03009	-	-	-	AAA_18
PYH1_k127_1681918_3	572478.Vdis_2267	0.0001659	47.0	arCOG05509@1|root,arCOG05509@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF1922
PYH1_k127_1681918_2	1459636.NTE_03306	1.604e-24	108.0	COG1958@1|root,arCOG00999@2157|Archaea	2157|Archaea	K	PFAM Like-Sm ribonucleoprotein, core	-	-	-	-	-	-	-	-	-	-	-	-	LSM,Lsm_C,SM-ATX
PYH1_k127_1681918_0	985053.VMUT_0301	3.879e-35	137.0	COG0343@1|root,arCOG00989@2157|Archaea,2XPSY@28889|Crenarchaeota	28889|Crenarchaeota	J	Exchanges the guanine residue with 7-cyano-7- deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D- loop) of archaeal tRNAs	tgtA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046116,GO:0046483,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.2.48	ko:K18779	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TGT
PYH1_k127_169517_0	563040.Saut_2076	2.213e-15	81.0	COG2199@1|root,COG3287@1|root,COG2199@2|Bacteria,COG3287@2|Bacteria,1RGCV@1224|Proteobacteria	1224|Proteobacteria	T	Diguanylate cyclase	yeaI	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0032879,GO:0040012,GO:0040013,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051270,GO:0051271,GO:0065007,GO:0071944,GO:1902021,GO:1902201,GO:2000145,GO:2000146	2.7.7.65,3.1.4.52	ko:K20959,ko:K20964	ko05111,map05111	-	-	-	ko00000,ko00001,ko01000	-	-	iAPECO1_1312.APECO1_853	CHASE,EAL,GGDEF,MASE4,NMT1,PAS_3,PAS_9
PYH1_k127_169517_1	944547.ABLL_1211	1.04e-11	70.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,42UQ6@68525|delta/epsilon subdivisions,2YTE3@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	T	PAS domain	-	-	-	ko:K03776	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	PAS_3
PYH1_k127_1707818_0	368408.Tpen_0622	2.438e-62	230.0	COG1467@1|root,arCOG04110@2157|Archaea,2XQI5@28889|Crenarchaeota	28889|Crenarchaeota	L	Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair	priS	GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0003896,GO:0003899,GO:0005488,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006269,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901363,GO:1901576	-	ko:K02683	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_primase_S
PYH1_k127_1709866_0	694440.JOMF01000005_gene288	3.872e-13	81.0	COG0477@1|root,arCOG00130@2157|Archaea	2157|Archaea	EGP	Major facilitator superfamily	-	-	-	ko:K08223	-	-	-	-	ko00000,ko02000	2.A.1.35	-	-	MFS_1
PYH1_k127_1709866_1	1169144.KB910934_gene4350	3.052e-06	51.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_23,Methyltransf_25,Methyltransf_31
PYH1_k127_1710909_0	1120971.AUCA01000010_gene2698	4.504e-12	79.0	COG1615@1|root,COG1615@2|Bacteria,1TQHM@1239|Firmicutes,4HCN4@91061|Bacilli	91061|Bacilli	S	Uncharacterised protein family (UPF0182)	-	-	-	ko:K09118	-	-	-	-	ko00000	-	-	-	UPF0182
PYH1_k127_1712079_1	1122212.AULO01000014_gene1201	1.811e-19	97.0	2BN8J@1|root,32GW0@2|Bacteria,1RH74@1224|Proteobacteria,1S7A4@1236|Gammaproteobacteria,1XM4F@135619|Oceanospirillales	135619|Oceanospirillales	S	LPP20 lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	LPP20
PYH1_k127_1714294_1	575590.HMPREF0156_00430	5.868e-25	111.0	2DPHF@1|root,33237@2|Bacteria,4P0MC@976|Bacteroidetes	976|Bacteroidetes	S	L-2-amino-thiazoline-4-carboxylic acid hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	ATC_hydrolase
PYH1_k127_1714294_2	504472.Slin_0852	2.171e-22	105.0	arCOG09454@1|root,30G4A@2|Bacteria,4NPSB@976|Bacteroidetes,47Q9D@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_1714294_0	1184251.TCELL_0808	3.674e-68	238.0	COG0410@1|root,arCOG00924@2157|Archaea,2XQDQ@28889|Crenarchaeota	28889|Crenarchaeota	E	ABC transporter	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
PYH1_k127_1714294_3	374847.Kcr_0799	2.073e-16	80.0	COG0411@1|root,arCOG00925@2157|Archaea	2157|Archaea	E	COG0411 ABC-type branched-chain amino acid transport systems ATPase component	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
PYH1_k127_1723139_0	340099.Teth39_2014	2.672e-77	265.0	COG1136@1|root,COG1136@2|Bacteria,1TPBJ@1239|Firmicutes,248EZ@186801|Clostridia,42FTY@68295|Thermoanaerobacterales	186801|Clostridia	V	Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides	macB	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
PYH1_k127_1723139_1	859657.RPSI07_mp0224	1.114e-07	60.0	COG1695@1|root,COG1695@2|Bacteria,1RHSE@1224|Proteobacteria,2VQCC@28216|Betaproteobacteria,1KH98@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	PadR
PYH1_k127_1723808_6	391623.TERMP_02143	2.496e-05	49.0	COG2104@1|root,arCOG00535@2157|Archaea,2Y5IW@28890|Euryarchaeota,244P9@183968|Thermococci	183968|Thermococci	H	ThiS family	-	-	-	-	-	-	-	-	-	-	-	-	ThiS
PYH1_k127_1723808_2	368408.Tpen_1412	8.036e-58	205.0	COG1142@1|root,arCOG01502@2157|Archaea,2XR9N@28889|Crenarchaeota	28889|Crenarchaeota	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_3,Fer4_4,Fer4_6,Fer4_9
PYH1_k127_1723808_0	1343739.PAP_00980	4.094e-215	685.0	COG2414@1|root,arCOG00709@2157|Archaea,2Y2PK@28890|Euryarchaeota,242X9@183968|Thermococci	183968|Thermococci	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
PYH1_k127_1723808_4	1131266.ARWQ01000005_gene854	6.905e-39	155.0	COG0722@1|root,arCOG00245@2157|Archaea,41SM0@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Prephenate dehydrogenase	-	-	1.3.1.12	ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025	R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	PDH
PYH1_k127_1723808_3	1408473.JHXO01000001_gene2348	2.594e-48	179.0	COG0652@1|root,COG0652@2|Bacteria,4NRWP@976|Bacteroidetes,2FY2X@200643|Bacteroidia	976|Bacteroidetes	M	Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD	-	-	5.2.1.8	ko:K03767	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Pro_isomerase
PYH1_k127_1723808_1	330779.Saci_0351	2.109e-63	231.0	COG0095@1|root,arCOG01939@2157|Archaea	2157|Archaea	H	PFAM Biotin lipoate A B protein ligase	lpl	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
PYH1_k127_1723808_5	1089553.Tph_c19600	6.339e-36	142.0	COG0509@1|root,COG0509@2|Bacteria,1V9VC@1239|Firmicutes,24QN1@186801|Clostridia,42IJ8@68295|Thermoanaerobacterales	186801|Clostridia	E	Glycine cleavage H-protein	-	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
PYH1_k127_1728163_0	456442.Mboo_2313	7.912e-16	82.0	COG5485@1|root,arCOG06513@2157|Archaea,2Y3E5@28890|Euryarchaeota	28890|Euryarchaeota	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL
PYH1_k127_1735267_0	926564.KI911693_gene1073	5.735e-63	226.0	COG1088@1|root,COG1088@2|Bacteria,2GNDU@201174|Actinobacteria,4F44B@85017|Promicromonosporaceae	201174|Actinobacteria	M	Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily	-	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
PYH1_k127_1735267_1	946077.W5A_13245	4.395e-05	54.0	COG0451@1|root,COG0451@2|Bacteria,4NI2U@976|Bacteroidetes,1I01P@117743|Flavobacteriia	976|Bacteroidetes	GM	dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
PYH1_k127_1745622_0	304371.MCP_2185	8.784e-38	147.0	COG0716@1|root,arCOG00519@2157|Archaea,2XZ4A@28890|Euryarchaeota	28890|Euryarchaeota	K	Flavodoxin	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red,Flavodoxin_4,HTH_5
PYH1_k127_1745622_1	1365176.N186_05250	1.671e-37	157.0	COG0477@1|root,arCOG00130@2157|Archaea,2XQ63@28889|Crenarchaeota	28889|Crenarchaeota	G	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
PYH1_k127_1761135_0	192952.MM_0718	1.669e-77	271.0	COG0644@1|root,arCOG00570@2157|Archaea,2XWXQ@28890|Euryarchaeota,2N9RD@224756|Methanomicrobia	224756|Methanomicrobia	C	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
PYH1_k127_1761135_1	186497.PF1102	5.831e-34	143.0	COG0142@1|root,arCOG01726@2157|Archaea,2XTAC@28890|Euryarchaeota,2435A@183968|Thermococci	183968|Thermococci	H	Belongs to the FPP GGPP synthase family	idsA	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13787	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
PYH1_k127_1832293_0	1151117.AJLF01000001_gene762	1.199e-284	893.0	COG0085@1|root,arCOG01762@2157|Archaea,2XU1X@28890|Euryarchaeota,24327@183968|Thermococci	183968|Thermococci	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K13798	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_4,RNA_pol_Rpb2_5,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
PYH1_k127_1832293_1	1343739.PAP_02715	1.233e-55	199.0	COG0086@1|root,arCOG04257@2157|Archaea,2XTBZ@28890|Euryarchaeota,242YY@183968|Thermococci	183968|Thermococci	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA1	-	2.7.7.6	ko:K03041	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
PYH1_k127_1837744_0	453591.Igni_0086	9.441e-78	269.0	COG0045@1|root,arCOG01337@2157|Archaea,2XPUW@28889|Crenarchaeota	28889|Crenarchaeota	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
PYH1_k127_1837744_1	304371.MCP_1481	9.433e-39	157.0	28M2T@1|root,2N55N@2157|Archaea,2Y31V@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_1837744_2	304371.MCP_1482	3.779e-38	147.0	COG0574@1|root,arCOG01114@2157|Archaea,2XVSY@28890|Euryarchaeota	28890|Euryarchaeota	G	pyruvate phosphate dikinase	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
PYH1_k127_1839558_0	1441930.Z042_19095	0.0004861	48.0	COG2223@1|root,COG2223@2|Bacteria,1MXAA@1224|Proteobacteria,1RMZZ@1236|Gammaproteobacteria,400HA@613|Serratia	1236|Gammaproteobacteria	P	Fosmidomycin resistance protein	fsr	GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016020,GO:0033554,GO:0042221,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0071944	-	ko:K08223	-	-	-	-	ko00000,ko02000	2.A.1.35	-	-	MFS_1
PYH1_k127_1845687_3	1158607.UAU_01629	2.722e-30	124.0	arCOG12597@1|root,2ZBJR@2|Bacteria,1V1R9@1239|Firmicutes,4I174@91061|Bacilli,4B2QI@81852|Enterococcaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_1845687_2	1347392.CCEZ01000013_gene2612	5.273e-38	148.0	COG1853@1|root,COG1853@2|Bacteria,1V4IU@1239|Firmicutes,25B2Z@186801|Clostridia,36JGZ@31979|Clostridiaceae	186801|Clostridia	S	Flavin reductase like domain	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
PYH1_k127_1845687_1	457570.Nther_0880	2.412e-39	151.0	COG0716@1|root,COG0716@2|Bacteria	2|Bacteria	C	FMN binding	-	-	1.6.5.2	ko:K03809	ko00130,ko01110,map00130,map01110	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	FMN_red,Flavodoxin_1,Flavodoxin_5
PYH1_k127_1845687_0	439481.Aboo_1401	3.007e-44	167.0	COG0535@1|root,arCOG00938@2157|Archaea,2XUDB@28890|Euryarchaeota,3F2ZN@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	4Fe-4S single cluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM
PYH1_k127_1856844_0	1121472.AQWN01000006_gene1827	1.198e-215	686.0	COG1148@1|root,COG1249@1|root,COG1148@2|Bacteria,COG1249@2|Bacteria,1V5YJ@1239|Firmicutes,248CC@186801|Clostridia,2641A@186807|Peptococcaceae	186801|Clostridia	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Pyr_redox_2
PYH1_k127_1914076_1	1123248.KB893333_gene2799	3.421e-102	350.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,4NHS5@976|Bacteroidetes	976|Bacteroidetes	EU	Peptidase, S9A B C family, catalytic domain protein	-	-	3.4.19.1	ko:K01303	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,Peptidase_S9
PYH1_k127_1914076_0	10228.TriadP62141	4.73e-177	566.0	COG0405@1|root,KOG2410@2759|Eukaryota,38ENY@33154|Opisthokonta,3BN8F@33208|Metazoa	33208|Metazoa	E	Gamma-glutamyltranspeptidase 2-like	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
PYH1_k127_1942203_2	391623.TERMP_00340	1.879e-30	123.0	COG1594@1|root,arCOG00579@2157|Archaea,2XXU7@28890|Euryarchaeota,2444S@183968|Thermococci	183968|Thermococci	K	Belongs to the archaeal rpoM eukaryotic RPA12 RPB9 RPC11 RNA polymerase family	-	-	-	ko:K03057	ko01100,map01100	-	-	-	br01611,ko00000,ko03021	-	-	-	RNA_POL_M_15KD,TFIIS_C
PYH1_k127_1942203_3	1198449.ACAM_0319	2.025e-26	118.0	COG0592@1|root,arCOG00488@2157|Archaea,2XQCF@28889|Crenarchaeota	28889|Crenarchaeota	L	Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication	pcn	GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006272,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0022616,GO:0030234,GO:0030337,GO:0032991,GO:0034641,GO:0034645,GO:0043170,GO:0043626,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0044796,GO:0046483,GO:0050790,GO:0065007,GO:0065009,GO:0071704,GO:0090304,GO:0098772,GO:1901360,GO:1901576	-	ko:K04802	ko03030,ko03410,ko03420,ko03430,ko04110,ko04530,ko05161,ko05166,map03030,map03410,map03420,map03430,map04110,map04530,map05161,map05166	M00295	-	-	ko00000,ko00001,ko00002,ko03032,ko03400	-	-	-	PCNA_C,PCNA_N
PYH1_k127_1942203_0	1459636.NTE_03195	2.503e-117	386.0	COG0040@1|root,arCOG02208@2157|Archaea,41SCJ@651137|Thaumarchaeota	651137|Thaumarchaeota	E	ATP phosphoribosyltransferase	-	-	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG,HisG_C
PYH1_k127_1942203_1	1229909.NSED_00715	3.162e-105	356.0	COG0141@1|root,arCOG04352@2157|Archaea,41S6J@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	-	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
PYH1_k127_1942203_4	1196322.A370_00152	0.0002299	47.0	COG0079@1|root,COG0079@2|Bacteria,1TPUV@1239|Firmicutes,24837@186801|Clostridia,36DDS@31979|Clostridiaceae	186801|Clostridia	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
PYH1_k127_2001823_0	574375.BAGA_21160	2.527e-82	283.0	COG0500@1|root,COG2226@2|Bacteria,1W0RA@1239|Firmicutes,4IS82@91061|Bacilli,1ZFRX@1386|Bacillus	91061|Bacilli	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
PYH1_k127_2001823_3	700508.D174_17910	3.649e-15	79.0	COG0438@1|root,COG0438@2|Bacteria,2GM6D@201174|Actinobacteria,2336Q@1762|Mycobacteriaceae	201174|Actinobacteria	M	GDP-mannose-dependent alpha-(1-6)-phosphatidylinositol monomannoside mannosyltransferase	pimB	GO:0000009,GO:0000030,GO:0003674,GO:0003824,GO:0004376,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0033164,GO:0040007,GO:0043750,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0070085,GO:0071704,GO:0071944,GO:0097502,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.4.1.346	ko:K13668	-	-	R11703,R11704	-	ko00000,ko01000,ko01003	-	GT4	-	Glyco_transf_4,Glycos_transf_1
PYH1_k127_2001823_2	1267534.KB906757_gene913	3.592e-57	211.0	COG1216@1|root,COG1216@2|Bacteria,3Y58N@57723|Acidobacteria,2JMPV@204432|Acidobacteriia	204432|Acidobacteriia	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
PYH1_k127_2001823_1	269799.Gmet_2010	1.961e-57	209.0	COG1216@1|root,COG1216@2|Bacteria,1MZSD@1224|Proteobacteria,42Q1D@68525|delta/epsilon subdivisions,2WJYJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	Glycos_transf_2
PYH1_k127_2042423_0	573413.Spirs_1723	2.271e-47	182.0	COG1829@1|root,COG1829@2|Bacteria	2|Bacteria	S	kinase activity	-	-	2.7.1.169	ko:K06982	ko00770,ko01100,map00770,map01100	-	R09378	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	GHMP_kinases_N
PYH1_k127_2042423_1	1122221.JHVI01000012_gene812	7.175e-42	167.0	COG1168@1|root,COG1168@2|Bacteria,1WI5E@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities	-	-	4.4.1.8	ko:K14155	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	-	R00782,R01286,R02408,R04941	RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
PYH1_k127_2054865_4	1347369.CCAD010000021_gene1578	0.000776	48.0	COG1073@1|root,COG1073@2|Bacteria,1UQS2@1239|Firmicutes,4HAMM@91061|Bacilli,1ZF40@1386|Bacillus	91061|Bacilli	S	X-Pro dipeptidyl-peptidase (S15 family)	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4,Peptidase_S15
PYH1_k127_2054865_2	264732.Moth_0272	2.668e-50	184.0	COG2316@1|root,COG2316@2|Bacteria,1TSF7@1239|Firmicutes,24A1B@186801|Clostridia,42G0N@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM metal-dependent phosphohydrolase, HD sub domain	-	-	-	ko:K06951	-	-	-	-	ko00000	-	-	-	HD
PYH1_k127_2054865_1	673860.AciM339_0063	6.314e-52	187.0	COG2872@1|root,arCOG01256@2157|Archaea,2Y3D7@28890|Euryarchaeota,3F3BD@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Alanyl-tRNA synthetase	-	GO:0002161,GO:0003674,GO:0003824,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA_SAD
PYH1_k127_2054865_3	673860.AciM339_1384	1.223e-10	71.0	COG1777@1|root,arCOG01684@2157|Archaea,2Y0DG@28890|Euryarchaeota,3F2TC@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	ko:K07721	-	-	-	-	ko00000,ko03000	-	-	-	HTH_20
PYH1_k127_2054865_0	1459636.NTE_01192	3.674e-194	617.0	COG0459@1|root,arCOG01257@2157|Archaea,41SDG@651137|Thaumarchaeota	651137|Thaumarchaeota	O	PFAM TCP-1 cpn60 chaperonin family	-	-	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
PYH1_k127_2055638_3	1050201.KB913034_gene1527	3.937e-10	61.0	COG0519@1|root,COG0519@2|Bacteria,1TPG8@1239|Firmicutes,3VNS1@526524|Erysipelotrichia	526524|Erysipelotrichia	F	Catalyzes the synthesis of GMP from XMP	guaA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase,tRNA_Me_trans
PYH1_k127_2055638_2	694440.JOMF01000005_gene28	1.495e-19	93.0	COG0517@1|root,arCOG00606@2157|Archaea,2XX11@28890|Euryarchaeota,2N9VZ@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS
PYH1_k127_2055638_1	1365176.N186_02605	5.639e-64	235.0	COG2234@1|root,arCOG02959@2157|Archaea	2157|Archaea	S	Peptidase M28	ywaD2	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
PYH1_k127_2055638_4	944479.JQLX01000011_gene820	4.419e-09	62.0	COG2314@1|root,COG2314@2|Bacteria	2|Bacteria	J	TM2 domain	-	-	-	-	-	-	-	-	-	-	-	-	TM2
PYH1_k127_2055638_0	273075.Ta1123	1.881e-114	380.0	COG0579@1|root,arCOG00754@2157|Archaea,2Y8CD@28890|Euryarchaeota	28890|Euryarchaeota	C	Dehydrogenase	-	-	1.1.5.3	ko:K00111,ko:K15736	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	BON,DAO,Fer2_BFD
PYH1_k127_2062521_1	1121396.KB893080_gene892	1.581e-89	304.0	COG1600@1|root,COG1600@2|Bacteria,1RAYI@1224|Proteobacteria,42R4W@68525|delta/epsilon subdivisions,2WK0B@28221|Deltaproteobacteria,2MJVT@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_2062521_0	479434.Sthe_0784	1.581e-144	469.0	COG0498@1|root,COG0498@2|Bacteria,2G5RK@200795|Chloroflexi,27Y4R@189775|Thermomicrobia	189775|Thermomicrobia	E	Threonine synthase	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
PYH1_k127_2062521_2	1094508.Tsac_1090	9.195e-41	154.0	COG1011@1|root,COG1011@2|Bacteria	2|Bacteria	S	phosphatase activity	-	-	3.1.3.5	ko:K07025,ko:K08723	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
PYH1_k127_2083583_0	1173024.KI912154_gene1186	1.248e-55	203.0	COG0596@1|root,COG0596@2|Bacteria,1GFX0@1117|Cyanobacteria,1JKES@1189|Stigonemataceae	1117|Cyanobacteria	S	Thioesterase domain	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
PYH1_k127_2087254_0	572546.Arcpr_0391	1.268e-24	106.0	COG1581@1|root,arCOG01753@2157|Archaea,2XZH4@28890|Euryarchaeota,246D0@183980|Archaeoglobi	183980|Archaeoglobi	K	Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes	-	-	-	ko:K03622	-	-	-	-	ko00000	-	-	-	Alba
PYH1_k127_2095803_0	342949.PNA2_0799	5.238e-32	134.0	COG0467@1|root,arCOG01171@2157|Archaea,2XTU3@28890|Euryarchaeota,242JC@183968|Thermococci	183968|Thermococci	T	Belongs to the UPF0273 family	-	-	-	-	-	-	-	-	-	-	-	-	ATPase
PYH1_k127_2095803_1	573064.Mefer_0036	1.187e-28	119.0	COG2125@1|root,arCOG01946@2157|Archaea,2XXZJ@28890|Euryarchaeota,23R2F@183939|Methanococci	183939|Methanococci	J	Belongs to the eukaryotic ribosomal protein eS6 family	rps6e	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0022613,GO:0022626,GO:0022627,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044085,GO:0044237,GO:0044238,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360,GO:1990904	-	ko:K02991	ko01521,ko03010,ko04066,ko04150,ko04151,ko04371,ko04714,ko04910,ko05205,map01521,map03010,map04066,map04150,map04151,map04371,map04714,map04910,map05205	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S6e
PYH1_k127_2124416_0	1157490.EL26_11975	4.689e-124	417.0	COG2234@1|root,COG2234@2|Bacteria	2|Bacteria	DZ	aminopeptidase activity	-	-	-	ko:K07004	-	-	-	-	ko00000	-	-	-	PKD,PPC,Peptidase_M10,Peptidase_M28,SLH
PYH1_k127_2131465_2	697303.Thewi_1735	1.094e-24	110.0	COG0546@1|root,COG0546@2|Bacteria,1V3YI@1239|Firmicutes,25KRT@186801|Clostridia,42H6U@68295|Thermoanaerobacterales	186801|Clostridia	S	TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 1	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
PYH1_k127_2131465_0	891968.Anamo_1805	1.77e-46	183.0	COG0477@1|root,COG2814@2|Bacteria,3TAXB@508458|Synergistetes	508458|Synergistetes	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like,Sugar_tr
PYH1_k127_2131465_3	410358.Mlab_0190	1.877e-20	91.0	arCOG03272@1|root,arCOG03272@2157|Archaea,2Y1VM@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	2.7.7.6	ko:K00960	-	-	-	-	ko00000,ko01000	-	-	-	-
PYH1_k127_2131465_1	368408.Tpen_1400	4.523e-42	162.0	COG1131@1|root,arCOG00194@2157|Archaea,2XPS7@28889|Crenarchaeota	28889|Crenarchaeota	V	PFAM ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
PYH1_k127_2131674_1	246194.CHY_1799	7.679e-15	76.0	2DBZQ@1|root,2ZC2Y@2|Bacteria,1V2KN@1239|Firmicutes,24G8V@186801|Clostridia,42I8U@68295|Thermoanaerobacterales	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_2131674_2	368408.Tpen_1442	4.11e-13	79.0	COG0640@1|root,arCOG01448@2157|Archaea	2157|Archaea	K	DNA-binding transcription factor activity	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_2131674_3	456442.Mboo_1708	0.0001212	48.0	COG0695@1|root,arCOG02607@2157|Archaea	2157|Archaea	O	COG3634 Alkyl hydroperoxide reductase, large subunit	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Glutaredoxin,Pyr_redox_2
PYH1_k127_2131674_0	323259.Mhun_2811	5.769e-201	641.0	COG1328@1|root,arCOG04889@2157|Archaea,2XT2S@28890|Euryarchaeota,2N92H@224756|Methanomicrobia	224756|Methanomicrobia	F	TIGRFAM anaerobic ribonucleoside-triphosphate reductase	nrdD	-	1.1.98.6	ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R11633,R11634,R11635,R11636	RC00613	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-cone,NRDD
PYH1_k127_2151204_2	1408439.JHXW01000002_gene731	6.437e-06	49.0	COG3653@1|root,COG3653@2|Bacteria,378ER@32066|Fusobacteria	32066|Fusobacteria	Q	Amidohydrolase family	-	-	3.5.1.81	ko:K06015	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Amidohydro_3
PYH1_k127_2151204_0	696281.Desru_0737	7.181e-59	212.0	COG2071@1|root,COG2071@2|Bacteria,1V1KC@1239|Firmicutes,24JCU@186801|Clostridia,261S6@186807|Peptococcaceae	186801|Clostridia	S	PFAM Peptidase C26	-	-	-	ko:K07010	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_C26
PYH1_k127_2151204_1	1296415.JACC01000023_gene4310	1.6e-11	73.0	COG0842@1|root,COG0842@2|Bacteria	2|Bacteria	V	Transport permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
PYH1_k127_2156528_0	521045.Kole_0510	3.754e-101	344.0	COG0285@1|root,COG0285@2|Bacteria,2GC0X@200918|Thermotogae	200918|Thermotogae	H	Belongs to the folylpolyglutamate synthase family	-	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M
PYH1_k127_2156528_1	1115512.EH105704_07_00390	2.011e-42	164.0	COG0524@1|root,COG0524@2|Bacteria,1R6C2@1224|Proteobacteria,1RWC9@1236|Gammaproteobacteria,3XQAZ@561|Escherichia	1236|Gammaproteobacteria	F	Catalyzes the ATP-dependent phosphorylation of fructoselysine to fructoselysine 6-phosphate. Functions in a fructoselysine degradation pathway that allows E.coli to grow on fructoselysine or psicoselysine. To a much lesser extenst, is also able to phosphorylate psicoselysine	frlD	GO:0003674,GO:0003824,GO:0005975,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0019200,GO:0044237,GO:0044238,GO:0044262,GO:0046835,GO:0071704	2.7.1.218	ko:K10710	-	-	R08124	RC00002,RC00017	ko00000,ko01000	-	-	iECs_1301.ECs4224,iETEC_1333.ETEC_3624	PfkB
PYH1_k127_2162102_2	273057.SSO0451	3.297e-12	74.0	COG5491@1|root,arCOG00452@2157|Archaea,2XQBW@28889|Crenarchaeota	28889|Crenarchaeota	D	Conserved protein implicated in secretion	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_2162102_1	930945.SiRe_1200	5.372e-36	144.0	COG5491@1|root,arCOG00452@2157|Archaea,2XQBW@28889|Crenarchaeota	28889|Crenarchaeota	D	Conserved protein implicated in secretion	-	-	-	-	-	-	-	-	-	-	-	-	Snf7
PYH1_k127_2162102_0	469616.FMAG_00494	4.598e-72	260.0	2BYY4@1|root,2Z80Y@2|Bacteria,379DX@32066|Fusobacteria	32066|Fusobacteria	S	Domain of unknown function (DUF4438)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4438
PYH1_k127_2172647_1	765177.Desmu_0398	1.112e-16	85.0	arCOG03871@1|root,arCOG03871@2157|Archaea,2XQZI@28889|Crenarchaeota	28889|Crenarchaeota	N	TIGRFAM archaeal flagellin N-terminal-like domain	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_2172647_0	1121333.JMLH01000083_gene2246	7.11e-26	111.0	COG0036@1|root,COG0036@2|Bacteria,1TQK8@1239|Firmicutes,3VQE1@526524|Erysipelotrichia	526524|Erysipelotrichia	G	Psort location Cytoplasmic, score	rpe	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
PYH1_k127_2175128_1	555088.DealDRAFT_2003	1.191e-52	201.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia,42KZ3@68298|Syntrophomonadaceae	186801|Clostridia	P	PFAM ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
PYH1_k127_2175128_3	1502852.FG94_00948	5.604e-05	53.0	COG0640@1|root,COG0640@2|Bacteria,1PGV0@1224|Proteobacteria,2WCK6@28216|Betaproteobacteria,477TZ@75682|Oxalobacteraceae	28216|Betaproteobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
PYH1_k127_2175128_0	580340.Tlie_1836	3.902e-139	452.0	COG1804@1|root,COG1804@2|Bacteria,3T9W8@508458|Synergistetes	508458|Synergistetes	C	PFAM L-carnitine dehydratase bile acid-inducible protein F	-	-	2.8.3.16,2.8.3.19	ko:K07749,ko:K18702	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
PYH1_k127_2175128_2	69014.TK2143	9.121e-52	189.0	COG1573@1|root,arCOG00905@2157|Archaea,2XUVI@28890|Euryarchaeota,243FM@183968|Thermococci	183968|Thermococci	L	Uracil DNA glycosylase superfamily	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
PYH1_k127_2186460_3	1236689.MMALV_07510	3.443e-27	115.0	COG1602@1|root,arCOG04269@2157|Archaea,2XTEQ@28890|Euryarchaeota,3F34R@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Archaeal Nre, N-terminal	nreA	-	-	-	-	-	-	-	-	-	-	-	Nre_C,Nre_N
PYH1_k127_2186460_1	293826.Amet_1088	1.504e-60	216.0	COG2364@1|root,COG2364@2|Bacteria,1V47R@1239|Firmicutes,24AXT@186801|Clostridia,36IJ3@31979|Clostridiaceae	186801|Clostridia	S	membrane	-	-	-	ko:K07149	-	-	-	-	ko00000	-	-	-	YitT_membrane
PYH1_k127_2186460_2	410359.Pcal_0725	7.206e-35	137.0	COG1832@1|root,arCOG04227@2157|Archaea,2XQW5@28889|Crenarchaeota	28889|Crenarchaeota	S	CoA binding domain	-	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
PYH1_k127_2186460_0	580340.Tlie_1718	9.404e-116	382.0	COG0028@1|root,COG0028@2|Bacteria,3TBY7@508458|Synergistetes	508458|Synergistetes	EH	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
PYH1_k127_2191767_0	1237149.C900_02054	2.093e-234	744.0	COG5549@1|root,COG5549@2|Bacteria,4NEA0@976|Bacteroidetes,47YDB@768503|Cytophagia	976|Bacteroidetes	O	Domain of unknown function (DUF5117)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4953,DUF5117,DUF5118
PYH1_k127_2191767_1	264732.Moth_0153	4.243e-25	106.0	COG1142@1|root,COG1142@2|Bacteria,1VH83@1239|Firmicutes,24TVN@186801|Clostridia,42JCX@68295|Thermoanaerobacterales	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_4,Fer4_7
PYH1_k127_2191767_2	368408.Tpen_0321	2.99e-08	60.0	COG2451@1|root,arCOG04304@2157|Archaea	2157|Archaea	J	Belongs to the eukaryotic ribosomal protein eL33 family	rpl35ae	-	-	ko:K02917	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35Ae
PYH1_k127_220060_1	926569.ANT_09340	6.471e-49	181.0	COG0265@1|root,COG0265@2|Bacteria,2G6KG@200795|Chloroflexi	200795|Chloroflexi	O	PFAM peptidase S1 and S6, chymotrypsin Hap	-	-	1.3.1.74,3.4.21.107	ko:K04771,ko:K08070	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
PYH1_k127_220060_2	658086.HMPREF0994_00356	1.447e-16	85.0	COG4728@1|root,COG4728@2|Bacteria,1UQC9@1239|Firmicutes,25833@186801|Clostridia,27PH4@186928|unclassified Lachnospiraceae	186801|Clostridia	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_220060_0	596315.HMPREF0634_1386	3.695e-108	359.0	COG2025@1|root,COG2025@2|Bacteria,1TPC8@1239|Firmicutes,247NF@186801|Clostridia,25QKB@186804|Peptostreptococcaceae	186801|Clostridia	C	electron transfer flavoprotein	etfA1	-	1.3.1.108	ko:K03522,ko:K22432	-	-	-	-	ko00000,ko01000,ko04147	-	-	-	ETF,ETF_alpha,Fer4
PYH1_k127_2204444_1	1041930.Mtc_0355	5.14e-130	424.0	COG1900@1|root,arCOG00620@2157|Archaea,2XVEU@28890|Euryarchaeota,2N93A@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,HcyBio
PYH1_k127_2204444_0	694429.Pyrfu_1762	2.738e-189	606.0	COG1245@1|root,arCOG00187@2157|Archaea,2XPQF@28889|Crenarchaeota	28889|Crenarchaeota	E	in RNase L inhibitor, RLI	-	-	-	ko:K06174	-	-	-	-	ko00000,ko03009	-	-	-	ABC_tran,Fer4,Fer4_6,RLI
PYH1_k127_2211997_1	797209.ZOD2009_14191	2.878e-52	196.0	COG1921@1|root,arCOG07389@2157|Archaea,2XU18@28890|Euryarchaeota,23SCH@183963|Halobacteria	183963|Halobacteria	E	COG1921 Selenocysteine synthase seryl-tRNASer selenium transferase	-	-	2.9.1.1	ko:K01042	ko00450,ko00970,map00450,map00970	-	R08219	RC01246	ko00000,ko00001,ko01000	-	-	-	Aminotran_5,SelA
PYH1_k127_2211997_0	575540.Isop_2641	2.299e-77	266.0	COG0365@1|root,COG0365@2|Bacteria,2IX5P@203682|Planctomycetes	203682|Planctomycetes	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
PYH1_k127_2214055_0	643648.Slip_2185	7.225e-37	143.0	COG1764@1|root,COG1764@2|Bacteria,1VYMJ@1239|Firmicutes,2538T@186801|Clostridia	186801|Clostridia	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
PYH1_k127_2214055_4	931626.Awo_c22540	5.552e-26	111.0	COG4273@1|root,COG4273@2|Bacteria,1UPTR@1239|Firmicutes,25HNZ@186801|Clostridia	186801|Clostridia	S	DGC domain	-	-	-	-	-	-	-	-	-	-	-	-	DGC
PYH1_k127_2214055_1	264732.Moth_2217	6.646e-29	120.0	COG4273@1|root,COG4273@2|Bacteria,1VPFX@1239|Firmicutes,24UUR@186801|Clostridia,42HFB@68295|Thermoanaerobacterales	186801|Clostridia	S	DGC domain	-	-	-	-	-	-	-	-	-	-	-	-	DGC
PYH1_k127_2214055_2	1118054.CAGW01000013_gene4049	1.787e-27	117.0	COG0509@1|root,COG0509@2|Bacteria,1V6WV@1239|Firmicutes,4HIMA@91061|Bacilli,26YGE@186822|Paenibacillaceae	91061|Bacilli	E	Is also involved in protein lipoylation via its role as an octanoyl lipoyl carrier protein intermediate	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
PYH1_k127_2214055_3	344747.PM8797T_22563	3.996e-27	114.0	COG0798@1|root,COG0798@2|Bacteria,2IY8H@203682|Planctomycetes	203682|Planctomycetes	P	COG0798 Arsenite efflux pump ACR3 and related	-	-	-	ko:K03325	-	-	-	-	ko00000,ko02000	2.A.59	-	-	SBF
PYH1_k127_231736_0	756883.Halar_2215	7.24e-17	90.0	arCOG03256@1|root,arCOG07560@1|root,arCOG03256@2157|Archaea,arCOG07560@2157|Archaea	2157|Archaea	Q	Archaeal Type IV pilin, N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,CarboxypepD_reg,PKD,Peptidase_S8,S-layer
PYH1_k127_2430190_3	1487923.DP73_03350	2.792e-54	193.0	COG2080@1|root,COG2080@2|Bacteria,1V6HE@1239|Firmicutes,24J9B@186801|Clostridia	186801|Clostridia	C	aerobic-type carbon monoxide dehydrogenase, small subunit CoxS	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
PYH1_k127_2430190_7	1347392.CCEZ01000049_gene1442	7.623e-24	108.0	COG2068@1|root,COG2068@2|Bacteria,1VCCX@1239|Firmicutes,25CVA@186801|Clostridia,36X1A@31979|Clostridiaceae	186801|Clostridia	S	Guanylyl transferase CofC like	-	-	2.7.7.76	ko:K07141	ko00790,map00790	-	R11582	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
PYH1_k127_2430190_8	1408428.JNJP01000122_gene1696	7.569e-18	83.0	COG1846@1|root,COG1846@2|Bacteria,1NMRK@1224|Proteobacteria,42XVG@68525|delta/epsilon subdivisions,2WSMR@28221|Deltaproteobacteria,2MDHC@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_2430190_6	926569.ANT_14480	5.945e-38	152.0	COG1975@1|root,COG1975@2|Bacteria,2G6H0@200795|Chloroflexi	200795|Chloroflexi	O	XdhC Rossmann domain	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI
PYH1_k127_2430190_4	246194.CHY_0691	3.021e-49	180.0	COG2080@1|root,COG2080@2|Bacteria,1V6HE@1239|Firmicutes,24J9B@186801|Clostridia,42I67@68295|Thermoanaerobacterales	186801|Clostridia	C	[2Fe-2S] binding domain	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
PYH1_k127_2430190_2	768706.Desor_0443	8.6e-57	209.0	COG1319@1|root,COG1319@2|Bacteria,1TQA5@1239|Firmicutes,248WI@186801|Clostridia,264MQ@186807|Peptococcaceae	186801|Clostridia	C	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM CutM-like protein	-	-	-	-	-	-	-	-	-	-	-	iHN637.CLJU_RS14760	CO_deh_flav_C,FAD_binding_5
PYH1_k127_2430190_0	1184251.TCELL_1088	1.008e-199	647.0	COG1529@1|root,arCOG01167@2157|Archaea,2XPS6@28889|Crenarchaeota	28889|Crenarchaeota	C	aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0016903,GO:0043546,GO:0044424,GO:0044464,GO:0048037,GO:0050662,GO:0055114,GO:0097159,GO:1901363	1.2.5.3,1.2.99.8	ko:K03520,ko:K18020	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R10324,R11168	RC00242,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
PYH1_k127_2430190_1	1121422.AUMW01000001_gene2319	6.113e-124	412.0	COG0469@1|root,COG0469@2|Bacteria,1TPGG@1239|Firmicutes,2489V@186801|Clostridia,260WY@186807|Peptococcaceae	186801|Clostridia	G	Belongs to the pyruvate kinase family	pyk	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PEP-utilizers,PK,PK_C
PYH1_k127_2430190_5	273068.TTE1794	3.901e-43	163.0	COG0501@1|root,COG0501@2|Bacteria,1TP23@1239|Firmicutes,24ACH@186801|Clostridia,42GEA@68295|Thermoanaerobacterales	186801|Clostridia	O	Belongs to the peptidase M48B family	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
PYH1_k127_2432934_0	1459636.NTE_00682	1.1e-177	570.0	COG0417@1|root,arCOG15272@2157|Archaea,41S91@651137|Thaumarchaeota	651137|Thaumarchaeota	L	DNA polymerase	-	-	2.7.7.7	ko:K02319	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_pol_B,DNA_pol_B_exo1
PYH1_k127_2432934_1	858215.Thexy_1254	5.909e-77	268.0	COG0017@1|root,COG0017@2|Bacteria,1TP38@1239|Firmicutes,2484D@186801|Clostridia,42HQY@68295|Thermoanaerobacterales	186801|Clostridia	J	nucleic acid binding OB-fold tRNA helicase-type	asnS	-	6.1.1.22	ko:K01893	ko00970,map00970	M00359,M00360	R03648	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
PYH1_k127_2447662_1	1379698.RBG1_1C00001G0857	6.44e-50	187.0	COG5557@1|root,COG5557@2|Bacteria,2NNNQ@2323|unclassified Bacteria	1379698.RBG1_1C00001G0857|-	C	Polysulphide reductase, NrfD	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_2447662_0	1121920.AUAU01000009_gene1859	5.367e-66	235.0	COG0437@1|root,COG0437@2|Bacteria,3Y2Z0@57723|Acidobacteria	57723|Acidobacteria	C	4Fe-4S dicluster domain	-	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	-
PYH1_k127_2447662_2	404380.Gbem_1125	4.65e-16	89.0	COG3043@1|root,COG3043@2|Bacteria,1RG8Q@1224|Proteobacteria,42S2W@68525|delta/epsilon subdivisions,2WNP8@28221|Deltaproteobacteria,43V2D@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Doubled CXXCH motif (Paired_CXXCH_1)	pccJ	-	-	-	-	-	-	-	-	-	-	-	Paired_CXXCH_1
PYH1_k127_2453741_2	529709.PYCH_06660	4.715e-41	158.0	COG1014@1|root,arCOG01603@2157|Archaea,2XVFR@28890|Euryarchaeota,243DZ@183968|Thermococci	183968|Thermococci	C	pyruvate synthase activity	porG	-	1.2.7.1,1.2.7.7	ko:K00172,ko:K00189	ko00010,ko00020,ko00280,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00280,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R07160,R08034,R08566,R08567	RC00004,RC00250,RC02742,RC02833,RC02856	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
PYH1_k127_2453741_3	930945.SiRe_2381	1.768e-20	93.0	COG1144@1|root,arCOG01605@2157|Archaea,2XQKJ@28889|Crenarchaeota	28889|Crenarchaeota	C	TIGRFAM pyruvate ferredoxin flavodoxin oxidoreductase, delta subunit	-	-	1.2.7.1	ko:K00171	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_21,Fer4_4
PYH1_k127_2453741_0	1121468.AUBR01000064_gene940	1.093e-93	333.0	COG0674@1|root,COG0674@2|Bacteria,1VS48@1239|Firmicutes,25E5U@186801|Clostridia,42EUF@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein	porA	-	1.2.7.1	ko:K00169	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
PYH1_k127_2453741_1	267377.MMP1504	4.501e-83	301.0	COG1013@1|root,arCOG01601@2157|Archaea,2XT3E@28890|Euryarchaeota,23Q2N@183939|Methanococci	183939|Methanococci	C	PFAM thiamine pyrophosphate protein domain protein TPP-binding	porB	-	1.2.7.1	ko:K00170	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
PYH1_k127_2495382_1	237368.SCABRO_03013	3.92e-08	63.0	28MYQ@1|root,2ZB5K@2|Bacteria,2IZUC@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_2495382_2	1379698.RBG1_1C00001G0118	1.942e-05	54.0	29ZH8@1|root,30MGZ@2|Bacteria,2NQ83@2323|unclassified Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_2495382_0	1379698.RBG1_1C00001G0115	2.396e-24	109.0	28MEN@1|root,2ZASA@2|Bacteria,2NQD3@2323|unclassified Bacteria	2|Bacteria	S	Evidence 5 No homology to any previously reported sequences	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_2502809_2	1321781.HMPREF1985_00311	2.731e-24	102.0	COG0426@1|root,COG0426@2|Bacteria,1TQE9@1239|Firmicutes,4H2BT@909932|Negativicutes	909932|Negativicutes	C	nitric oxide	roo	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_1,Lactamase_B
PYH1_k127_2502809_0	269797.Mbar_A1789	1.362e-79	276.0	COG1234@1|root,arCOG00501@2157|Archaea,2XTJ9@28890|Euryarchaeota,2N96S@224756|Methanomicrobia	224756|Methanomicrobia	J	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA	rnz	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
PYH1_k127_2502809_1	880073.Calab_1650	7.215e-57	204.0	COG0492@1|root,COG0492@2|Bacteria,2NNS7@2323|unclassified Bacteria	2|Bacteria	O	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	trxB	GO:0000166,GO:0001666,GO:0003674,GO:0003824,GO:0004791,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0008152,GO:0009628,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019725,GO:0036094,GO:0036293,GO:0040007,GO:0042221,GO:0042592,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070402,GO:0070482,GO:0070887,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748	1.8.1.9	ko:K00384,ko:K03671	ko00450,ko04621,ko05418,map00450,map04621,map05418	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000,ko03110	-	-	iNJ661.Rv3913	Pyr_redox_2,Thioredoxin
PYH1_k127_2508873_1	926550.CLDAP_01850	7.122e-21	96.0	COG1668@1|root,COG1668@2|Bacteria,2G76A@200795|Chloroflexi	200795|Chloroflexi	CP	ABC-2 family transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_2
PYH1_k127_2508873_0	485913.Krac_1772	7.162e-73	256.0	COG1131@1|root,COG1131@2|Bacteria,2G6HA@200795|Chloroflexi	200795|Chloroflexi	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
PYH1_k127_2508873_3	649761.HMPREF0973_01377	7.921e-14	83.0	COG0477@1|root,COG2814@2|Bacteria,4NE1N@976|Bacteroidetes,2FW79@200643|Bacteroidia	976|Bacteroidetes	EGP	Transporter, major facilitator family protein	fsr	-	-	ko:K08223	-	-	-	-	ko00000,ko02000	2.A.1.35	-	-	MFS_1
PYH1_k127_2508873_2	748449.Halha_1373	9.593e-15	76.0	COG1363@1|root,COG1363@2|Bacteria,1TNZT@1239|Firmicutes,248D0@186801|Clostridia,3WBWU@53433|Halanaerobiales	186801|Clostridia	G	M42 glutamyl aminopeptidase	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	Peptidase_M42
PYH1_k127_2521939_0	192952.MM_2307	1.772e-94	326.0	COG0165@1|root,arCOG01748@2157|Archaea,2XUWS@28890|Euryarchaeota,2N9AC@224756|Methanomicrobia	224756|Methanomicrobia	E	TIGRFAM argininosuccinate lyase	argH	-	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
PYH1_k127_2521939_1	591019.Shell_0930	2.27e-79	275.0	COG1940@1|root,arCOG04280@2157|Archaea,2XPSQ@28889|Crenarchaeota	28889|Crenarchaeota	G	PFAM ROK family protein	-	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
PYH1_k127_2521939_2	1075090.GOAMR_20_00780	1.758e-14	76.0	COG0179@1|root,COG0179@2|Bacteria,2GN2G@201174|Actinobacteria,4GATT@85026|Gordoniaceae	201174|Actinobacteria	Q	Domain of unknown function (DUF2437)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2437,FAA_hydrolase
PYH1_k127_2528519_2	679926.Mpet_2608	3.63e-06	55.0	COG0517@1|root,arCOG00600@2157|Archaea,2Y88V@28890|Euryarchaeota,2NBP3@224756|Methanomicrobia	224756|Methanomicrobia	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
PYH1_k127_2528519_0	565033.GACE_0099	1.896e-56	207.0	arCOG06549@1|root,arCOG06549@2157|Archaea,2Y31C@28890|Euryarchaeota,246R3@183980|Archaeoglobi	183980|Archaeoglobi	C	NapC/NirT cytochrome c family, N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_NNT
PYH1_k127_2528519_3	237368.SCABRO_03298	0.0003146	50.0	COG1633@1|root,COG1633@2|Bacteria	2|Bacteria	S	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
PYH1_k127_2528519_1	1089544.KB912942_gene4091	9.229e-11	64.0	COG0665@1|root,COG0665@2|Bacteria,2GMR7@201174|Actinobacteria	201174|Actinobacteria	E	D-amino acid	-	-	1.4.5.1	ko:K00285	ko00360,map00360	-	R01374,R09493	RC00006,RC00025	ko00000,ko00001,ko01000	-	-	-	DAO
PYH1_k127_2546264_2	192875.XP_004347933.1	1.863e-18	87.0	COG1171@1|root,KOG1251@2759|Eukaryota,3AN59@33154|Opisthokonta	33154|Opisthokonta	ET	ammonia-lyase activity	Srr	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0003941,GO:0005488,GO:0005509,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006090,GO:0006520,GO:0006563,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009056,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016020,GO:0016043,GO:0016053,GO:0016594,GO:0016597,GO:0016829,GO:0016840,GO:0016841,GO:0016853,GO:0016854,GO:0016855,GO:0017076,GO:0017144,GO:0018114,GO:0019752,GO:0019842,GO:0019904,GO:0022607,GO:0030165,GO:0030170,GO:0030378,GO:0030554,GO:0030848,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0035639,GO:0036094,GO:0036361,GO:0036477,GO:0042165,GO:0042219,GO:0042802,GO:0042803,GO:0042866,GO:0043025,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044297,GO:0044424,GO:0044464,GO:0045177,GO:0046394,GO:0046416,GO:0046437,GO:0046872,GO:0046983,GO:0047661,GO:0048037,GO:0050662,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0070178,GO:0070179,GO:0070279,GO:0071704,GO:0071840,GO:0071944,GO:0072330,GO:0097159,GO:0097367,GO:0097458,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901607	5.1.1.18	ko:K12235	ko00260,ko01100,map00260,map01100	-	R00589	RC00302	ko00000,ko00001,ko01000	-	-	-	PALP
PYH1_k127_2546264_1	177437.HRM2_41530	1.985e-27	119.0	COG4591@1|root,COG4591@2|Bacteria,1QWP2@1224|Proteobacteria,43BU0@68525|delta/epsilon subdivisions,2X74Z@28221|Deltaproteobacteria,2MPK3@213118|Desulfobacterales	28221|Deltaproteobacteria	M	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX
PYH1_k127_2546264_0	591019.Shell_1043	6.942e-95	316.0	COG1136@1|root,arCOG00922@2157|Archaea,2XQG8@28889|Crenarchaeota	28889|Crenarchaeota	V	PFAM ABC transporter related	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
PYH1_k127_2546264_3	1303518.CCALI_00750	8.332e-13	80.0	COG0577@1|root,COG2234@1|root,COG0577@2|Bacteria,COG2234@2|Bacteria	2|Bacteria	DZ	aminopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
PYH1_k127_2550428_0	436308.Nmar_1261	3.035e-106	359.0	COG0621@1|root,arCOG01358@2157|Archaea,41SB9@651137|Thaumarchaeota	651137|Thaumarchaeota	J	MiaB-like tRNA modifying enzyme	-	-	2.8.4.5	ko:K15865	-	-	R10649	RC00003,RC03221	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,UPF0004
PYH1_k127_2550428_1	585531.HMPREF0063_11180	1.485e-06	52.0	COG2267@1|root,COG2267@2|Bacteria,2GJ78@201174|Actinobacteria,4DNQD@85009|Propionibacteriales	201174|Actinobacteria	I	Serine aminopeptidase, S33	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
PYH1_k127_2550951_0	756272.Plabr_3379	1.341e-85	295.0	COG1070@1|root,COG1070@2|Bacteria,2IY9E@203682|Planctomycetes	203682|Planctomycetes	G	MutL protein	-	-	-	-	-	-	-	-	-	-	-	-	MutL
PYH1_k127_2550951_1	593117.TGAM_0219	9.081e-12	72.0	COG0640@1|root,arCOG01687@2157|Archaea,2Y1FZ@28890|Euryarchaeota,243EZ@183968|Thermococci	183968|Thermococci	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
PYH1_k127_2569167_5	374847.Kcr_1561	5.047e-23	103.0	COG0198@1|root,arCOG04094@2157|Archaea	2157|Archaea	J	Located at the polypeptide exit tunnel on the outside of the subunit	rpl24	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,Ribosomal_L26
PYH1_k127_2569167_0	1220534.B655_1499	4.727e-55	201.0	COG1471@1|root,arCOG04093@2157|Archaea,2XT03@28890|Euryarchaeota,23NT9@183925|Methanobacteria	183925|Methanobacteria	J	Belongs to the eukaryotic ribosomal protein eS4 family	rps4e	-	-	ko:K02987	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	RS4NT,Ribosomal_S4e,S4
PYH1_k127_2569167_2	453591.Igni_1411	5.497e-48	177.0	COG0094@1|root,arCOG04092@2157|Archaea,2XQDJ@28889|Crenarchaeota	28889|Crenarchaeota	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rpl5	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
PYH1_k127_2569167_6	368408.Tpen_0241	3.607e-13	70.0	COG0199@1|root,arCOG00782@2157|Archaea,2XR7G@28889|Crenarchaeota	28889|Crenarchaeota	J	Binds 16S rRNA, required for the assembly of 30S particles	rps14	GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008270,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043167,GO:0043169,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:1990904	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
PYH1_k127_2569167_3	604354.TSIB_0304	2.719e-40	152.0	COG0096@1|root,arCOG04091@2157|Archaea,2XWMU@28890|Euryarchaeota,2440K@183968|Thermococci	183968|Thermococci	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rps8	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
PYH1_k127_2569167_1	694429.Pyrfu_1675	4.187e-48	177.0	COG0097@1|root,arCOG04090@2157|Archaea,2XQ9A@28889|Crenarchaeota	28889|Crenarchaeota	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rpl6	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
PYH1_k127_2569167_4	246969.TAM4_280	3.857e-30	124.0	COG1717@1|root,arCOG00781@2157|Archaea,2XSZ4@28890|Euryarchaeota,2447U@183968|Thermococci	183968|Thermococci	J	Belongs to the eukaryotic ribosomal protein eL32 family	rpl32e	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02912	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L32e
PYH1_k127_2570861_0	374847.Kcr_0648	4.617e-60	218.0	COG1260@1|root,arCOG04213@2157|Archaea	2157|Archaea	I	myo-inositol-1-phosphate synthase	ino1	-	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth,NAD_binding_5
PYH1_k127_2570861_1	572478.Vdis_1780	1.598e-54	200.0	COG1100@1|root,arCOG01225@2157|Archaea,2XQ2Q@28889|Crenarchaeota	28889|Crenarchaeota	S	ATP binding protein	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	ATP_bind_1
PYH1_k127_2570861_2	1094980.Mpsy_2850	7.789e-40	153.0	COG2423@1|root,arCOG01035@2157|Archaea,2XTTC@28890|Euryarchaeota,2N94J@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the NAD( )-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate	ala	-	1.4.1.1	ko:K19244	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	OCD_Mu_crystall
PYH1_k127_257254_0	386456.JQKN01000012_gene1040	3.993e-174	568.0	COG0068@1|root,arCOG01187@2157|Archaea,2XTHZ@28890|Euryarchaeota,23NPD@183925|Methanobacteria	183925|Methanobacteria	O	Belongs to the carbamoyltransferase HypF family	hypF	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
PYH1_k127_257254_3	1229909.NSED_09625	1.205e-05	55.0	arCOG08041@1|root,arCOG08041@2157|Archaea,41SRT@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	HTH_27
PYH1_k127_257254_2	452637.Oter_2041	6.068e-16	82.0	COG1917@1|root,COG1917@2|Bacteria,46WJU@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PFAM Cupin 2 conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
PYH1_k127_257254_1	1041930.Mtc_0452	2.978e-82	290.0	COG1311@1|root,arCOG04455@2157|Archaea,2XSUG@28890|Euryarchaeota,2N96N@224756|Methanomicrobia	224756|Methanomicrobia	L	Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase	polB	-	2.7.7.7	ko:K02323	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	M00264	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	DNA_pol_E_B,Metallophos,tRNA_anti-codon
PYH1_k127_2598821_0	1123257.AUFV01000008_gene517	7.843e-63	229.0	COG2843@1|root,COG2843@2|Bacteria,1P1MG@1224|Proteobacteria	1224|Proteobacteria	M	Capsule synthesis protein	-	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
PYH1_k127_2604409_0	760568.Desku_2114	2.735e-167	542.0	COG0446@1|root,COG0607@1|root,COG0446@2|Bacteria,COG0607@2|Bacteria,1TPWW@1239|Firmicutes,2484C@186801|Clostridia,2606T@186807|Peptococcaceae	186801|Clostridia	P	pyridine nucleotide-disulphide oxidoreductase dimerisation	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim,Rhodanese
PYH1_k127_2604409_1	1455608.JDTH01000001_gene2896	8.497e-34	134.0	COG0537@1|root,arCOG00419@2157|Archaea,2XXWC@28890|Euryarchaeota,23V8Q@183963|Halobacteria	183963|Halobacteria	F	COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases	hit2	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
PYH1_k127_2605554_1	1430331.EP10_00165	4.722e-33	128.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1TR2N@1239|Firmicutes,4H9RR@91061|Bacilli,1WEQC@129337|Geobacillus	91061|Bacilli	EU	Acetyl xylan esterase (AXE1)	yuxL	-	3.4.19.1	ko:K01303	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,Peptidase_S9
PYH1_k127_2605554_0	1408439.JHXW01000002_gene485	1.051e-65	232.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,378MC@32066|Fusobacteria	32066|Fusobacteria	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribBA	-	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2
PYH1_k127_2639170_0	351160.RCIX1676	1.819e-142	469.0	COG3299@1|root,arCOG10307@2157|Archaea	2157|Archaea	S	Baseplate J family protein	-	-	-	-	-	-	-	-	-	-	-	-	Baseplate_J
PYH1_k127_2639170_4	351160.RCIX1675	2.225e-35	139.0	COG3628@1|root,arCOG11183@2157|Archaea	2157|Archaea	S	Phage baseplate assembly protein W	-	-	-	ko:K06903	-	-	-	-	ko00000	-	-	-	GPW_gp25
PYH1_k127_2639170_2	489825.LYNGBM3L_03960	2.888e-48	175.0	COG4104@1|root,COG4104@2|Bacteria	2|Bacteria	T	PAAR repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	PAAR_motif
PYH1_k127_2639170_1	351160.RCIX1671	5.068e-49	184.0	COG3501@1|root,arCOG10240@2157|Archaea	2157|Archaea	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_2639170_3	351160.RCIX1667	2.318e-45	171.0	arCOG00372@1|root,arCOG00372@2157|Archaea	2157|Archaea	P	cobalamin transport	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_2718076_1	1122221.JHVI01000042_gene1557	1.912e-50	185.0	COG1704@1|root,COG1704@2|Bacteria,1WK85@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	PFAM LemA family protein	-	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
PYH1_k127_2718076_2	592015.HMPREF1705_02170	3.939e-45	179.0	COG0477@1|root,COG2814@2|Bacteria,3TAXB@508458|Synergistetes	508458|Synergistetes	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like,Sugar_tr
PYH1_k127_2718076_0	891968.Anamo_1805	1.347e-54	208.0	COG0477@1|root,COG2814@2|Bacteria,3TAXB@508458|Synergistetes	508458|Synergistetes	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like,Sugar_tr
PYH1_k127_2718076_3	1035308.AQYY01000002_gene199	1.116e-35	145.0	2ANM6@1|root,31DKG@2|Bacteria,1TUK2@1239|Firmicutes,25I50@186801|Clostridia,2668F@186807|Peptococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_2741064_3	985053.VMUT_1824	6.176e-07	57.0	COG1630@1|root,arCOG00367@2157|Archaea,2XSDH@28889|Crenarchaeota	28889|Crenarchaeota	L	NurA	-	-	-	-	-	-	-	-	-	-	-	-	NurA
PYH1_k127_2741064_1	368408.Tpen_0864	9.36e-24	111.0	COG0750@1|root,arCOG04064@2157|Archaea,2XQGN@28889|Crenarchaeota	28889|Crenarchaeota	M	PFAM peptidase M50	-	-	-	-	-	-	-	-	-	-	-	-	PDZ,PDZ_2,Peptidase_M50
PYH1_k127_2741064_0	415426.Hbut_0892	6.472e-58	209.0	COG2413@1|root,arCOG04066@2157|Archaea,2XQ4I@28889|Crenarchaeota	28889|Crenarchaeota	S	DNA polymerase beta domain protein region	-	-	-	ko:K07073	-	-	-	-	ko00000	-	-	-	NTP_transf_2
PYH1_k127_2741064_2	572546.Arcpr_1825	1.19e-23	105.0	COG0358@1|root,arCOG04281@2157|Archaea,2XTHB@28890|Euryarchaeota,245WB@183980|Archaeoglobi	183980|Archaeoglobi	L	DNA primase	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	Toprim_4
PYH1_k127_2742852_1	555088.DealDRAFT_1029	4.574e-23	108.0	COG0651@1|root,COG0651@2|Bacteria,1UIA7@1239|Firmicutes,25EF6@186801|Clostridia,42KZ1@68298|Syntrophomonadaceae	186801|Clostridia	C	PFAM NADH Ubiquinone plastoquinone (complex I)	-	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M,Proton_antipo_N
PYH1_k127_2742852_3	1538644.KO02_19635	1.134e-13	74.0	COG0713@1|root,COG0713@2|Bacteria,4NSR8@976|Bacteroidetes,1ITB0@117747|Sphingobacteriia	976|Bacteroidetes	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK	-	1.6.5.3	ko:K00340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
PYH1_k127_2742852_4	1434325.AZQN01000003_gene2184	5.305e-05	49.0	COG0839@1|root,COG0839@2|Bacteria,4NQM8@976|Bacteroidetes	976|Bacteroidetes	C	PFAM NADH-ubiquinone plastoquinone oxidoreductase chain 6	-	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
PYH1_k127_2742852_0	313612.L8106_10151	3.807e-23	105.0	COG1143@1|root,COG1143@2|Bacteria,1G0WD@1117|Cyanobacteria,1H8PK@1150|Oscillatoriales	1117|Cyanobacteria	C	electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient	ndhI	-	1.6.5.3	ko:K05580	ko00190,ko01100,map00190,map01100	M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_7
PYH1_k127_2742852_2	1535422.ND16A_0091	2.614e-22	100.0	COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,1RQE9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0031224,GO:0031226,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
PYH1_k127_2838258_0	945713.IALB_0243	1.913e-171	542.0	COG0612@1|root,COG0612@2|Bacteria	2|Bacteria	L	Peptidase, M16	pqqL	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
PYH1_k127_2838258_1	1239962.C943_04497	2.018e-41	158.0	COG3832@1|root,COG3832@2|Bacteria,4NPHR@976|Bacteroidetes,47T5V@768503|Cytophagia	976|Bacteroidetes	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
PYH1_k127_2838258_3	945713.IALB_3108	2.416e-26	109.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	cccE	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
PYH1_k127_2845458_5	373903.Hore_11180	3.796e-14	75.0	COG0778@1|root,COG0778@2|Bacteria,1V2ST@1239|Firmicutes,25M95@186801|Clostridia,3WC0K@53433|Halanaerobiales	186801|Clostridia	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
PYH1_k127_2845458_3	994573.T472_0207930	1.63e-42	163.0	COG4430@1|root,COG4430@2|Bacteria,1V1VF@1239|Firmicutes,249ZH@186801|Clostridia,36I7W@31979|Clostridiaceae	186801|Clostridia	S	Bacteriocin-protection, YdeI or OmpD-Associated	-	-	-	-	-	-	-	-	-	-	-	-	OmdA
PYH1_k127_2845458_2	563192.HMPREF0179_00127	3.816e-45	170.0	COG0655@1|root,COG0655@2|Bacteria	2|Bacteria	S	NAD(P)H dehydrogenase (quinone) activity	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
PYH1_k127_2845458_6	862967.SIR_0837	1.064e-05	57.0	COG0477@1|root,COG2814@2|Bacteria,1UZKT@1239|Firmicutes,4HDHS@91061|Bacilli,42CYM@671232|Streptococcus anginosus group	91061|Bacilli	EGP	Major Facilitator Superfamily	pmrB	-	-	-	-	-	-	-	-	-	-	-	MFS_1
PYH1_k127_2845458_1	566466.NOR53_1077	5.127e-90	314.0	COG5476@1|root,COG5476@2|Bacteria,1MX4P@1224|Proteobacteria,1S1GU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Involved in peptidolytic degradation of cyclic heptapeptide hepatotoxin microcystin (MC)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1485,MlrC_C
PYH1_k127_2845458_7	158190.SpiGrapes_1557	3.329e-05	51.0	COG0662@1|root,COG0662@2|Bacteria,2J7PT@203691|Spirochaetes	203691|Spirochaetes	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
PYH1_k127_2845458_4	1265505.ATUG01000002_gene2379	1.12e-34	141.0	COG1148@1|root,COG1148@2|Bacteria,1R0SK@1224|Proteobacteria,43EFN@68525|delta/epsilon subdivisions,2X89E@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
PYH1_k127_2845458_0	679926.Mpet_1648	4.62e-98	346.0	COG4907@1|root,arCOG03432@2157|Archaea,2XVA0@28890|Euryarchaeota,2NA0A@224756|Methanomicrobia	224756|Methanomicrobia	S	Predicted membrane protein (DUF2207)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2207
PYH1_k127_296022_0	70601.3258282	9.41e-75	265.0	COG0438@1|root,arCOG01403@2157|Archaea,2XTRH@28890|Euryarchaeota,242SB@183968|Thermococci	183968|Thermococci	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
PYH1_k127_296022_1	553220.CAMGR0001_1049	1.828e-10	65.0	COG0586@1|root,COG0586@2|Bacteria,1MX4M@1224|Proteobacteria,42RMJ@68525|delta/epsilon subdivisions,2YMZV@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	PFAM SNARE associated Golgi protein	dedA	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
PYH1_k127_300313_0	5833.MAL13P1.231	2.494e-74	258.0	COG0201@1|root,KOG1373@2759|Eukaryota,3Y9GN@5794|Apicomplexa,3KBK8@422676|Aconoidasida,3YYHJ@5819|Haemosporida	422676|Aconoidasida	U	Plug domain of Sec61p	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K10956	ko03060,ko04141,ko04145,ko05110,map03060,map04141,map04145,map05110	M00401	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.4,3.A.5.8,3.A.5.9	-	-	Plug_translocon,SecY
PYH1_k127_300313_3	1459636.NTE_02795	4.65e-29	121.0	COG0200@1|root,arCOG00779@2157|Archaea,41SQY@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Binds to the 23S rRNA	rpl15	-	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
PYH1_k127_300313_2	224719.Abm4_1255	3.485e-40	153.0	COG1841@1|root,arCOG04086@2157|Archaea,2XWGP@28890|Euryarchaeota,23P1Y@183925|Methanobacteria	183925|Methanobacteria	J	ribosomal protein	rpl30	-	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
PYH1_k127_300313_1	1163730.FFONT_0500	8.136e-59	207.0	COG0098@1|root,arCOG04087@2157|Archaea,2XPK9@28889|Crenarchaeota	28889|Crenarchaeota	J	With S4 and S12 plays an important role in translational accuracy	rps5	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
PYH1_k127_3091713_3	572546.Arcpr_1399	1.752e-37	145.0	COG1900@1|root,arCOG00620@2157|Archaea,2XVEU@28890|Euryarchaeota,2463B@183980|Archaeoglobi	183980|Archaeoglobi	S	Pfam:DUF39	-	-	-	-	-	-	-	-	-	-	-	-	CBS,HcyBio
PYH1_k127_3091713_4	693661.Arcve_1084	8.242e-28	116.0	COG1145@1|root,arCOG02460@2157|Archaea,2Y0N6@28890|Euryarchaeota,246EW@183980|Archaeoglobi	183980|Archaeoglobi	C	4Fe-4S ferredoxin iron-sulfur binding	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,NIL
PYH1_k127_3091713_2	573063.Metin_1053	1.906e-44	170.0	COG2122@1|root,arCOG04376@2157|Archaea,2XV48@28890|Euryarchaeota,23QEX@183939|Methanococci	183939|Methanococci	S	Belongs to the UPF0280 family	-	-	-	ko:K09740	-	-	-	-	ko00000	-	-	-	-
PYH1_k127_3091713_0	374847.Kcr_0131	6.828e-70	251.0	COG0527@1|root,arCOG00861@2157|Archaea	2157|Archaea	E	Belongs to the aspartokinase family	lysC	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT_7
PYH1_k127_3091713_1	1220534.B655_0106	1.779e-61	229.0	COG0034@1|root,arCOG00093@2157|Archaea,2XSWJ@28890|Euryarchaeota,23NJB@183925|Methanobacteria	183925|Methanobacteria	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
PYH1_k127_3091713_5	1343739.PAP_08310	1.045e-24	110.0	COG1763@1|root,arCOG00532@2157|Archaea,2XVAX@28890|Euryarchaeota,24387@183968|Thermococci	183968|Thermococci	H	molybdopterin-guanine dinucleotide biosynthesis protein	-	-	-	ko:K03753	-	-	-	-	ko00000	-	-	-	FeS,MobB
PYH1_k127_310945_2	521045.Kole_0476	4.447e-17	82.0	COG2516@1|root,COG2516@2|Bacteria,2GCTT@200918|Thermotogae	200918|Thermotogae	S	PFAM Radical SAM domain protein	-	-	2.8.1.6	ko:K01012	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
PYH1_k127_310945_0	592015.HMPREF1705_00648	4.206e-78	268.0	COG0095@1|root,COG0095@2|Bacteria,3TBDG@508458|Synergistetes	508458|Synergistetes	H	PFAM Biotin lipoate A B protein ligase family	-	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
PYH1_k127_310945_3	1122130.AUHN01000010_gene421	1.25e-11	68.0	COG0095@1|root,COG0095@2|Bacteria,2GJV5@201174|Actinobacteria	201174|Actinobacteria	H	biotin lipoate A B protein ligase	lplA	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
PYH1_k127_310945_1	439481.Aboo_0647	1.101e-34	140.0	COG1856@1|root,arCOG05825@2157|Archaea,2XY8U@28890|Euryarchaeota,3F2XV@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Elongator protein 3, MiaB family, Radical SAM	-	-	-	ko:K09711	-	-	-	-	ko00000	-	-	-	Radical_SAM
PYH1_k127_3144080_2	926560.KE387025_gene4033	1.361e-20	96.0	COG0607@1|root,COG0607@2|Bacteria,1WJ03@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
PYH1_k127_3144080_1	304371.MCP_0914	1.147e-25	114.0	COG4635@1|root,arCOG00524@2157|Archaea	2157|Archaea	CH	flavodoxin	hemG	-	1.3.5.3	ko:K00230	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R09489	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavodoxin_5
PYH1_k127_3144080_0	1459636.NTE_03146	7.371e-43	163.0	COG0071@1|root,arCOG01833@2157|Archaea	2157|Archaea	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
PYH1_k127_3216019_0	857293.CAAU_0008	0.0007079	51.0	2BDKE@1|root,3279U@2|Bacteria,1UT5Z@1239|Firmicutes,251HG@186801|Clostridia,36SAF@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_3221087_2	665956.HMPREF1032_02369	2.604e-45	166.0	COG3808@1|root,COG3808@2|Bacteria,1TNZI@1239|Firmicutes,248KS@186801|Clostridia,3WHVU@541000|Ruminococcaceae	186801|Clostridia	C	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
PYH1_k127_3221087_1	339860.Msp_1243	6.917e-52	187.0	COG1632@1|root,arCOG04209@2157|Archaea,2XTJJ@28890|Euryarchaeota,23NJV@183925|Methanobacteria	183925|Methanobacteria	J	Belongs to the eukaryotic ribosomal protein eL15 family	rpl15e	-	-	ko:K02877	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L15e
PYH1_k127_3221087_4	374847.Kcr_1366	5.003e-23	108.0	COG0463@1|root,arCOG01386@2157|Archaea	2157|Archaea	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
PYH1_k127_3221087_0	1459636.NTE_00750	2.976e-88	300.0	COG0111@1|root,arCOG01754@2157|Archaea,41S8U@651137|Thaumarchaeota	651137|Thaumarchaeota	H	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
PYH1_k127_3221087_3	415426.Hbut_0550	1.38e-42	158.0	COG0012@1|root,arCOG00357@2157|Archaea,2XPTY@28889|Crenarchaeota	28889|Crenarchaeota	J	GTPase of	-	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,MMR_HSR1_C,TGS
PYH1_k127_3229861_1	1220534.B655_1160	1.531e-30	128.0	COG4635@1|root,arCOG00524@2157|Archaea,2Y1YN@28890|Euryarchaeota	28890|Euryarchaeota	C	Flavodoxin domain	-	-	1.3.5.3	ko:K00230	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R09489	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavodoxin_5
PYH1_k127_3229861_0	403833.Pmob_1874	4.09e-107	355.0	COG2217@1|root,COG2217@2|Bacteria,2GDR0@200918|Thermotogae	200918|Thermotogae	P	E1-E2 ATPase	-	-	3.6.3.4	ko:K01533	-	-	R00086	RC00002	ko00000,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hydrolase
PYH1_k127_3252163_2	1094980.Mpsy_1026	2.267e-25	115.0	COG0644@1|root,arCOG00570@2157|Archaea,2XUI9@28890|Euryarchaeota,2N9DD@224756|Methanomicrobia	224756|Methanomicrobia	C	TIGRFAM geranylgeranyl reductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3,HI0933_like,Lycopene_cycl
PYH1_k127_3252163_3	415426.Hbut_1353	5.159e-18	84.0	COG2888@1|root,arCOG01989@2157|Archaea,2XRFA@28889|Crenarchaeota	28889|Crenarchaeota	J	Domain of unknown function (DUF1610)	-	-	-	ko:K07580	-	-	-	-	ko00000	-	-	-	DUF1610
PYH1_k127_3252163_1	673860.AciM339_1239	5.756e-28	117.0	COG1990@1|root,arCOG04228@2157|Archaea,2XYRE@28890|Euryarchaeota,3F2T0@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Peptidyl-tRNA hydrolase PTH2	pth	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	3.1.1.29	ko:K04794	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	PTH2
PYH1_k127_3252163_0	572546.Arcpr_0998	6.161e-127	419.0	COG0017@1|root,arCOG00406@2157|Archaea,2XTRE@28890|Euryarchaeota,2460D@183980|Archaeoglobi	183980|Archaeoglobi	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.23	ko:K09759	ko00970,map00970	M00360	R03647,R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
PYH1_k127_3256372_0	593117.TGAM_0040	2.826e-87	306.0	COG0651@1|root,arCOG01537@2157|Archaea,2XU88@28890|Euryarchaeota,242ND@183968|Thermococci	183968|Thermococci	C	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus	-	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M,Proton_antipo_N
PYH1_k127_3256372_2	517417.Cpar_1301	5.564e-07	55.0	COG0713@1|root,COG0713@2|Bacteria,1FE6D@1090|Chlorobi	1090|Chlorobi	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK	-	1.6.5.3	ko:K00340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
PYH1_k127_3256372_3	13035.Dacsa_2519	2.119e-05	49.0	COG0839@1|root,COG0839@2|Bacteria,1G2WH@1117|Cyanobacteria	1117|Cyanobacteria	C	Belongs to the complex I subunit 6 family	ndhG	-	1.6.5.3	ko:K05578	ko00190,ko01100,map00190,map01100	M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	-	-	-	Oxidored_q3
PYH1_k127_3256372_1	273068.TTE1699	6.82e-20	94.0	COG1143@1|root,COG1143@2|Bacteria,1UCGF@1239|Firmicutes,24HKT@186801|Clostridia,42GPS@68295|Thermoanaerobacterales	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	-	ko:K12143	-	-	-	-	ko00000	-	-	-	Fer4,Fer4_7
PYH1_k127_3272481_0	224325.AF_0273	4.691e-152	496.0	COG0446@1|root,arCOG01294@2157|Archaea,2XUFI@28890|Euryarchaeota,246RK@183980|Archaeoglobi	183980|Archaeoglobi	C	2Fe-2S iron-sulfur cluster binding domain	-	-	1.5.3.1	ko:K00302	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Pyr_redox_2
PYH1_k127_3272481_1	589924.Ferp_2558	4.554e-20	92.0	COG0446@1|root,arCOG05745@2157|Archaea,2XZPN@28890|Euryarchaeota,246DF@183980|Archaeoglobi	183980|Archaeoglobi	C	BFD-like [2Fe-2S] binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer2_BFD
PYH1_k127_3282338_0	398767.Glov_3666	3.944e-164	528.0	COG3039@1|root,COG3039@2|Bacteria,1MVTU@1224|Proteobacteria,42Q03@68525|delta/epsilon subdivisions,2WMFQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Transposase domain (DUF772)	-	-	-	ko:K07481	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
PYH1_k127_3294580_0	1365176.N186_00730	2.273e-66	232.0	COG1249@1|root,arCOG01068@2157|Archaea,2XPKZ@28889|Crenarchaeota	28889|Crenarchaeota	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
PYH1_k127_3294580_2	648996.Theam_0591	8.693e-55	196.0	COG1225@1|root,COG1225@2|Bacteria,2G42T@200783|Aquificae	200783|Aquificae	O	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
PYH1_k127_3294580_1	511051.CSE_02560	3.635e-63	222.0	COG0778@1|root,COG0778@2|Bacteria	2|Bacteria	C	coenzyme F420-1:gamma-L-glutamate ligase activity	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Nitroreductase
PYH1_k127_3308901_2	688269.Theth_0530	6.485e-27	120.0	COG0527@1|root,COG0527@2|Bacteria,2GD4P@200918|Thermotogae	200918|Thermotogae	E	Belongs to the aspartokinase family	-	-	1.1.1.3,2.7.2.4	ko:K00928,ko:K12524	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480,R01773,R01775	RC00002,RC00043,RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT_7
PYH1_k127_3308901_0	479434.Sthe_1459	1.782e-131	432.0	COG0498@1|root,COG0498@2|Bacteria,2G66Y@200795|Chloroflexi,27XPE@189775|Thermomicrobia	189775|Thermomicrobia	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
PYH1_k127_3308901_1	1166018.FAES_3672	1.443e-62	226.0	COG0083@1|root,COG0083@2|Bacteria,4NE2M@976|Bacteroidetes,47KGY@768503|Cytophagia	976|Bacteroidetes	E	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate	thrB	-	2.7.1.39	ko:K00872	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
PYH1_k127_3321022_0	471853.Bcav_0201	3.268e-64	242.0	COG1680@1|root,COG1680@2|Bacteria,2GNNF@201174|Actinobacteria	201174|Actinobacteria	V	Beta-lactamase	ampC2	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
PYH1_k127_3321022_1	269797.Mbar_A0124	2.271e-22	101.0	arCOG02703@1|root,arCOG02703@2157|Archaea	2157|Archaea	S	Methyltransferase type 11	aknG	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11,Methyltransf_25,Methyltransf_31
PYH1_k127_3367826_0	192952.MM_2931	2.813e-143	467.0	COG0607@1|root,arCOG00517@1|root,arCOG00517@2157|Archaea,arCOG02021@2157|Archaea,2XSV0@28890|Euryarchaeota,2N97K@224756|Methanomicrobia	224756|Methanomicrobia	P	Rhodanese-like domain	-	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	Lactamase_B,Rhodanese
PYH1_k127_3436887_0	1379698.RBG1_1C00001G0115	1.558e-55	204.0	28MEN@1|root,2ZASA@2|Bacteria,2NQD3@2323|unclassified Bacteria	2|Bacteria	S	Evidence 5 No homology to any previously reported sequences	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_3436887_1	1379698.RBG1_1C00001G0118	9.068e-22	103.0	29ZH8@1|root,30MGZ@2|Bacteria,2NQ83@2323|unclassified Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_3443312_0	572546.Arcpr_0656	2.239e-85	300.0	COG1032@1|root,arCOG01356@2157|Archaea,2XU04@28890|Euryarchaeota,245XG@183980|Archaeoglobi	183980|Archaeoglobi	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
PYH1_k127_3443312_1	1121439.dsat_0483	4.136e-55	199.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,4308T@68525|delta/epsilon subdivisions,2X5CQ@28221|Deltaproteobacteria,2MGPK@213115|Desulfovibrionales	28221|Deltaproteobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
PYH1_k127_3476217_2	1267535.KB906767_gene3126	5.713e-45	177.0	COG0520@1|root,COG0520@2|Bacteria	2|Bacteria	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
PYH1_k127_3476217_0	449447.MAE_15810	4.498e-121	409.0	COG2866@1|root,COG2866@2|Bacteria,1G1CQ@1117|Cyanobacteria	1117|Cyanobacteria	E	PFAM peptidase M14, carboxypeptidase A	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
PYH1_k127_3476217_1	56780.SYN_00663	1.08e-47	177.0	COG1751@1|root,COG1751@2|Bacteria,1RBXI@1224|Proteobacteria,42R3D@68525|delta/epsilon subdivisions,2WMRV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Pyruvate kinase, alpha/beta domain	-	-	-	ko:K09126	-	-	-	-	ko00000	-	-	-	PK_C
PYH1_k127_3476217_3	547559.Nmag_3999	8.578e-13	71.0	COG2843@1|root,arCOG07503@2157|Archaea	2157|Archaea	M	enzyme of poly-gamma-glutamate biosynthesis (Capsule formation)	-	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
PYH1_k127_3479768_2	1365176.N186_01720	3.677e-19	97.0	COG1215@1|root,arCOG01389@2157|Archaea	2157|Archaea	M	PFAM Glycosyl transferase family 2	-	-	-	ko:K00786	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_tranf_2_3,Glyco_trans_2_3,Glycos_transf_2
PYH1_k127_3479768_1	945713.IALB_3117	1.729e-39	150.0	2DTJ6@1|root,33KM6@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_3479768_3	591019.Shell_0969	3.097e-18	90.0	arCOG03871@1|root,arCOG03871@2157|Archaea,2XQZI@28889|Crenarchaeota	28889|Crenarchaeota	N	TIGRFAM archaeal flagellin N-terminal-like domain	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_3479768_0	436308.Nmar_1135	1.495e-113	386.0	COG0421@1|root,arCOG00050@2157|Archaea	2157|Archaea	H	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	speE	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synt_N,Spermine_synth
PYH1_k127_3511060_1	909663.KI867150_gene1672	1.11e-27	118.0	COG0003@1|root,COG0003@2|Bacteria,1MUTX@1224|Proteobacteria,42V9Y@68525|delta/epsilon subdivisions,2WND5@28221|Deltaproteobacteria,2MS8W@213462|Syntrophobacterales	28221|Deltaproteobacteria	D	Anion-transporting ATPase	arsA	-	3.6.3.16	ko:K01551	-	-	-	-	ko00000,ko01000,ko02000	3.A.19.1,3.A.21.1,3.A.4.1	-	-	ArsA_ATPase
PYH1_k127_3511060_0	666686.B1NLA3E_07870	8.645e-106	358.0	COG1032@1|root,COG1032@2|Bacteria,1UW6M@1239|Firmicutes,4IJS5@91061|Bacilli,1ZE1F@1386|Bacillus	91061|Bacilli	C	COG1032 Fe-S oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding
PYH1_k127_353008_2	224325.AF_0936	2.445e-13	78.0	COG1989@1|root,arCOG02298@2157|Archaea,2XUQP@28890|Euryarchaeota,24693@183980|Archaeoglobi	183980|Archaeoglobi	N	Peptidase A24B, FlaK domain protein	-	-	3.4.23.52	ko:K07991	-	-	-	-	ko00000,ko01000,ko01002,ko02035,ko02044	-	-	-	Arc_PepC_II,Peptidase_A24
PYH1_k127_353008_0	350688.Clos_1595	1.614e-46	173.0	COG0494@1|root,COG0494@2|Bacteria,1V6F5@1239|Firmicutes,24JFS@186801|Clostridia,36ITW@31979|Clostridiaceae	186801|Clostridia	L	nudix family	nudF	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
PYH1_k127_353008_1	304371.MCP_2483	2.369e-42	164.0	COG2509@1|root,arCOG02231@2157|Archaea,2XTVH@28890|Euryarchaeota,2N9BS@224756|Methanomicrobia	224756|Methanomicrobia	S	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	ko:K07137	-	-	-	-	ko00000	-	-	-	FAD_binding_2,HI0933_like,Pyr_redox_2
PYH1_k127_3530440_0	1211817.CCAT010000067_gene467	1.25e-121	408.0	COG0714@1|root,COG1112@1|root,COG0714@2|Bacteria,COG1112@2|Bacteria,1TP20@1239|Firmicutes,24BMH@186801|Clostridia,36GFE@31979|Clostridiaceae	186801|Clostridia	L	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_11,AAA_12,DUF3320,DUF4011,DUF559
PYH1_k127_3559129_0	195522.BD01_2055	1.849e-124	407.0	COG0075@1|root,arCOG00082@2157|Archaea,2XTWU@28890|Euryarchaeota,243N5@183968|Thermococci	183968|Thermococci	E	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
PYH1_k127_3559129_2	195522.BD01_1955	8.732e-23	101.0	COG1254@1|root,arCOG01674@2157|Archaea,2XYT5@28890|Euryarchaeota,2449Y@183968|Thermococci	183968|Thermococci	C	acylphosphatase activity	acyP	GO:0003674,GO:0003824,GO:0003998,GO:0016787,GO:0016817,GO:0016818	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	-	R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000	-	-	-	Acylphosphatase
PYH1_k127_3559129_1	1343739.PAP_06285	2.392e-45	168.0	COG0409@1|root,arCOG04428@2157|Archaea,2XTJA@28890|Euryarchaeota,2437J@183968|Thermococci	183968|Thermococci	O	formation protein HypD	hypD	-	-	ko:K04654	-	-	-	-	ko00000	-	-	-	HypD
PYH1_k127_35675_2	374847.Kcr_0368	2.693e-52	195.0	COG0281@1|root,arCOG01331@2157|Archaea	2157|Archaea	C	Zn-dependent protease with chaperone function	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
PYH1_k127_35675_0	415426.Hbut_1178	7.123e-120	408.0	COG0018@1|root,arCOG00487@2157|Archaea,2XPXC@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the class-I aminoacyl-tRNA synthetase family	argS	GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
PYH1_k127_35675_1	457570.Nther_0112	2.015e-57	212.0	COG0042@1|root,COG0042@2|Bacteria,1TQ2R@1239|Firmicutes,248HD@186801|Clostridia	186801|Clostridia	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	dus	-	-	ko:K05540	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
PYH1_k127_35675_3	661478.OP10G_4561	3.911e-10	67.0	COG3173@1|root,COG3173@2|Bacteria	2|Bacteria	S	very-long-chain-acyl-CoA dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	APH,EcKinase,PhoU
PYH1_k127_36369_1	572478.Vdis_0989	3.133e-105	351.0	COG0017@1|root,arCOG00409@2157|Archaea,2XPWE@28889|Crenarchaeota	28889|Crenarchaeota	J	PFAM tRNA synthetase, class II (D, K and N)	-	-	6.1.1.22	ko:K01893	ko00970,map00970	M00359,M00360	R03648	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2
PYH1_k127_36369_3	368408.Tpen_0018	1.855e-40	154.0	COG1522@1|root,arCOG01580@2157|Archaea,2XQYS@28889|Crenarchaeota	28889|Crenarchaeota	K	PFAM regulatory protein AsnC Lrp family	-	-	-	ko:K03718	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
PYH1_k127_36369_2	985255.APHJ01000035_gene32	1.556e-75	267.0	COG0150@1|root,COG0150@2|Bacteria,4NE4E@976|Bacteroidetes,1HXGD@117743|Flavobacteriia,2P6IY@244698|Gillisia	976|Bacteroidetes	F	AIR synthase related protein, C-terminal domain	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
PYH1_k127_36369_0	324602.Caur_0103	6.305e-140	456.0	COG0006@1|root,COG0006@2|Bacteria	2|Bacteria	E	proline dipeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M24
PYH1_k127_36369_4	265729.GS18_0218750	1.243e-24	111.0	COG1309@1|root,COG1309@2|Bacteria,1VDNV@1239|Firmicutes,4HKG8@91061|Bacilli,1ZI66@1386|Bacillus	91061|Bacilli	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_6,TetR_N
PYH1_k127_3649086_1	204536.SULAZ_0349	1.795e-47	178.0	COG0367@1|root,COG0367@2|Bacteria,2G4Q5@200783|Aquificae	200783|Aquificae	F	Asparagine synthase	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
PYH1_k127_3649086_0	1379698.RBG1_1C00001G1736	7.525e-64	230.0	COG2244@1|root,COG2244@2|Bacteria	2|Bacteria	S	polysaccharide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_C
PYH1_k127_3689995_1	1337936.IJ00_12170	1.393e-10	64.0	COG0847@1|root,COG0847@2|Bacteria,1GHMF@1117|Cyanobacteria,1HQ1A@1161|Nostocales	1117|Cyanobacteria	L	EXOIII	-	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
PYH1_k127_3689995_0	1121940.AUDZ01000005_gene1761	4.13e-35	139.0	2DMWM@1|root,32U4H@2|Bacteria,1N2SS@1224|Proteobacteria,1S9T8@1236|Gammaproteobacteria,1XM71@135619|Oceanospirillales	135619|Oceanospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_3694958_4	391595.RLO149_c026730	1.733e-16	88.0	COG0546@1|root,COG0546@2|Bacteria,1RDDY@1224|Proteobacteria,2U79T@28211|Alphaproteobacteria,2P2U7@2433|Roseobacter	28211|Alphaproteobacteria	S	haloacid dehalogenase-like hydrolase	gph	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
PYH1_k127_3694958_1	323259.Mhun_1244	7.729e-98	327.0	COG2013@1|root,arCOG01907@2157|Archaea,2XW0I@28890|Euryarchaeota	28890|Euryarchaeota	S	Mitochondrial biogenesis AIM24	-	-	-	-	-	-	-	-	-	-	-	-	AIM24
PYH1_k127_3694958_3	436308.Nmar_0521	8.586e-25	111.0	COG1386@1|root,arCOG02613@2157|Archaea,41SIC@651137|Thaumarchaeota	651137|Thaumarchaeota	K	segregation and condensation protein	-	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
PYH1_k127_3694958_0	269797.Mbar_A3513	2.695e-107	361.0	COG0151@1|root,arCOG04415@2157|Archaea,2XTRV@28890|Euryarchaeota,2N976@224756|Methanomicrobia	224756|Methanomicrobia	F	PFAM Phosphoribosylglycinamide synthetase	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A3513	GARS_A,GARS_C,GARS_N
PYH1_k127_3694958_2	1121936.AUHI01000016_gene97	1.344e-40	165.0	COG0520@1|root,COG0520@2|Bacteria,1TRDP@1239|Firmicutes,4HBP7@91061|Bacilli	91061|Bacilli	E	Aminotransferase	ycbU	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
PYH1_k127_3733610_1	1220534.B655_1868	7.102e-15	77.0	COG1371@1|root,arCOG04055@2157|Archaea,2XXRX@28890|Euryarchaeota	28890|Euryarchaeota	S	Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently	-	GO:0000394,GO:0003674,GO:0005488,GO:0005509,GO:0006139,GO:0006388,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008380,GO:0009987,GO:0010467,GO:0016070,GO:0034470,GO:0034641,GO:0034660,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0071704,GO:0090304,GO:1901360	-	-	-	-	-	-	-	-	-	-	Archease
PYH1_k127_3733610_0	485916.Dtox_1600	1.108e-238	749.0	COG0369@1|root,COG1151@2|Bacteria,1TP8X@1239|Firmicutes,247IN@186801|Clostridia,2601X@186807|Peptococcaceae	186801|Clostridia	C	Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O	hcp	-	1.7.99.1	ko:K05601	ko00910,map00910	-	R00143	RC02797	ko00000,ko00001,ko01000	-	-	-	Prismane
PYH1_k127_3733610_2	1336234.JAGN01000002_gene1006	4.234e-11	68.0	COG0640@1|root,COG0640@2|Bacteria,1VA6G@1239|Firmicutes,4HKYT@91061|Bacilli,27GY3@186828|Carnobacteriaceae	91061|Bacilli	K	helix_turn_helix, Arsenical Resistance Operon Repressor	czrA	-	-	ko:K22043	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
PYH1_k127_3737448_0	1229909.NSED_09795	0.0001095	50.0	COG2512@1|root,arCOG00374@2157|Archaea,41SUX@651137|Thaumarchaeota	651137|Thaumarchaeota	K	membrane-associated protein domain	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_374011_0	1379698.RBG1_1C00001G0120	2.621e-51	186.0	28II6@1|root,2Z8JB@2|Bacteria,2NNT1@2323|unclassified Bacteria	2|Bacteria	S	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_378668_3	118173.KB235914_gene2496	3.779e-14	76.0	COG2217@1|root,COG2217@2|Bacteria,1GBJF@1117|Cyanobacteria,1HEUT@1150|Oscillatoriales	1117|Cyanobacteria	P	metallochaperone-like domain	-	-	-	-	-	-	-	-	-	-	-	-	E1-E2_ATPase,Hydrolase,YHS
PYH1_k127_378668_0	706587.Desti_1267	2.042e-191	621.0	COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,42N1K@68525|delta/epsilon subdivisions,2WIT6@28221|Deltaproteobacteria,2MQAG@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
PYH1_k127_378668_1	529709.PYCH_13930	1.257e-72	251.0	COG0149@1|root,arCOG01087@2157|Archaea,2XTY3@28890|Euryarchaeota,24332@183968|Thermococci	183968|Thermococci	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM,ThiG
PYH1_k127_378668_2	673860.AciM339_1571	1.731e-39	152.0	COG1109@1|root,arCOG00767@2157|Archaea,2XT1X@28890|Euryarchaeota,3F2G6@33867|unclassified Euryarchaeota	28890|Euryarchaeota	G	phosphoglucomutase phosphomannomutase alpha beta alpha domain I	pmm4	-	5.4.2.2,5.4.2.8	ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A2225	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
PYH1_k127_3792144_0	1303518.CCALI_02317	1.39e-153	496.0	COG3579@1|root,COG3579@2|Bacteria	2|Bacteria	E	homocysteine catabolic process	pepC	GO:0000096,GO:0000098,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006508,GO:0006520,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008234,GO:0009056,GO:0009063,GO:0009636,GO:0009987,GO:0016054,GO:0016787,GO:0019538,GO:0019752,GO:0042221,GO:0043170,GO:0043418,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044273,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046395,GO:0050667,GO:0050896,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	3.4.22.40	ko:K01372	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_C1_2
PYH1_k127_37975_3	930945.SiRe_0930	1.543e-09	62.0	COG1591@1|root,arCOG00919@2157|Archaea	2157|Archaea	L	A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products	-	-	3.1.22.4	ko:K03552	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Hjc
PYH1_k127_37975_2	523850.TON_0438	6.018e-27	117.0	arCOG01806@1|root,arCOG01806@2157|Archaea,2XWT7@28890|Euryarchaeota,243TC@183968|Thermococci	183968|Thermococci	S	ACT domain	-	-	-	-	-	-	-	-	-	-	-	-	ACT_7
PYH1_k127_37975_1	1229909.NSED_03205	8.725e-30	121.0	COG0023@1|root,arCOG04223@2157|Archaea,41SNU@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the SUI1 family	-	-	-	ko:K03113	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	SUI1
PYH1_k127_37975_0	374847.Kcr_1212	8.429e-100	335.0	COG0468@1|root,arCOG00415@2157|Archaea	2157|Archaea	L	Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules	radA	GO:0000150,GO:0000217,GO:0000400,GO:0000724,GO:0000725,GO:0000730,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003697,GO:0003824,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006312,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022607,GO:0033554,GO:0034622,GO:0034641,GO:0042148,GO:0042623,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0045003,GO:0046483,GO:0050896,GO:0051716,GO:0065003,GO:0065004,GO:0071704,GO:0071824,GO:0071840,GO:0090304,GO:0090735,GO:0097159,GO:0140097,GO:1901360,GO:1901363	-	ko:K04483	-	-	-	-	ko00000,ko03400	-	-	-	HHH_5,Rad51
PYH1_k127_3843534_1	1380394.JADL01000001_gene3011	0.0005081	44.0	COG2045@1|root,COG2045@2|Bacteria,1N3KG@1224|Proteobacteria,2UR25@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	2-phosphosulpholactate phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	2-ph_phosp
PYH1_k127_3843534_0	351160.LRC224	3.441e-117	389.0	COG0172@1|root,arCOG00403@2157|Archaea,2XTGA@28890|Euryarchaeota,2NADB@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
PYH1_k127_3936812_0	342949.PNA2_0765	1.733e-95	329.0	COG1530@1|root,arCOG00321@2157|Archaea,2XU9U@28890|Euryarchaeota,24370@183968|Thermococci	183968|Thermococci	L	Putative modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
PYH1_k127_3980561_1	397948.Cmaq_1396	4.477e-08	57.0	arCOG06505@1|root,arCOG06505@2157|Archaea,2XRQB@28889|Crenarchaeota	28889|Crenarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_3980561_0	1502724.FF80_03157	7.143e-106	358.0	COG0624@1|root,COG0624@2|Bacteria,1MW2W@1224|Proteobacteria,2TQYZ@28211|Alphaproteobacteria,3N8TN@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Peptidase dimerisation domain	-	-	3.5.1.16	ko:K01438	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R00669,R09107	RC00064,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
PYH1_k127_3999489_5	797210.Halxa_3345	3.366e-12	69.0	COG1400@1|root,arCOG01217@2157|Archaea,2XYV0@28890|Euryarchaeota,23WWX@183963|Halobacteria	183963|Halobacteria	J	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP	srp19	-	-	ko:K03105	ko03060,map03060	-	-	-	ko00000,ko00001,ko02044	3.A.5.7,3.A.5.9	-	-	SRP19
PYH1_k127_3999489_2	243232.MJ_0673	1.539e-26	113.0	COG2007@1|root,arCOG04154@2157|Archaea,2XYXX@28890|Euryarchaeota,23R0Z@183939|Methanococci	183939|Methanococci	J	PFAM ribosomal protein S8E	rps8e	GO:0000462,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044085,GO:0044237,GO:0044238,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360,GO:1990904	-	ko:K02995	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8e
PYH1_k127_3999489_0	634498.mru_1551	5.658e-117	385.0	COG0309@1|root,arCOG00636@2157|Archaea,2XTAH@28890|Euryarchaeota,23NWV@183925|Methanobacteria	183925|Methanobacteria	O	TIGRFAM hydrogenase expression formation protein HypE	-	-	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
PYH1_k127_3999489_1	1229909.NSED_02620	3.452e-27	119.0	COG1386@1|root,arCOG02613@2157|Archaea,41SIC@651137|Thaumarchaeota	651137|Thaumarchaeota	K	segregation and condensation protein	-	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
PYH1_k127_3999489_4	436308.Nmar_0522	1.783e-13	79.0	COG1354@1|root,arCOG02610@2157|Archaea,41SMU@651137|Thaumarchaeota	651137|Thaumarchaeota	L	chromosome segregation and condensation protein ScpA	-	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	-
PYH1_k127_3999489_3	604354.TSIB_0722	3.875e-26	109.0	COG1196@1|root,arCOG00371@2157|Archaea,2XSVK@28890|Euryarchaeota,242QE@183968|Thermococci	183968|Thermococci	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
PYH1_k127_40320_0	1283300.ATXB01000001_gene1059	1.702e-08	63.0	2EB0T@1|root,3351P@2|Bacteria,1NCHM@1224|Proteobacteria,1SJ6Z@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_4069564_2	246194.CHY_1799	2.245e-30	126.0	2DBZQ@1|root,2ZC2Y@2|Bacteria,1V2KN@1239|Firmicutes,24G8V@186801|Clostridia,42I8U@68295|Thermoanaerobacterales	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_4069564_0	604354.TSIB_0337	7.616e-101	338.0	COG0130@1|root,arCOG00987@2157|Archaea,2XTUE@28890|Euryarchaeota,243K5@183968|Thermococci	183968|Thermococci	J	Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs	truB	GO:0000154,GO:0000495,GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016072,GO:0016073,GO:0016074,GO:0016556,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0031120,GO:0031123,GO:0031126,GO:0033979,GO:0034470,GO:0034641,GO:0034660,GO:0034964,GO:0040031,GO:0042254,GO:0043144,GO:0043170,GO:0043412,GO:0043628,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360,GO:1990481	-	ko:K11131	ko03008,map03008	M00425	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03032	-	-	-	DKCLD,PUA,TruB_C_2,TruB_N
PYH1_k127_4069564_1	415426.Hbut_1330	3.555e-47	176.0	COG2126@1|root,arCOG00110@2157|Archaea,2XQ8A@28889|Crenarchaeota	28889|Crenarchaeota	Q	PFAM methyltransferase small	-	-	-	-	-	-	-	-	-	-	-	-	MTS
PYH1_k127_4069564_4	453591.Igni_0706	1.252e-13	76.0	COG1522@1|root,arCOG01580@2157|Archaea,2XQS8@28889|Crenarchaeota	28889|Crenarchaeota	K	ASNC family	-	-	-	ko:K03718	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
PYH1_k127_4069564_5	186497.PF1601	4.339e-11	70.0	COG1522@1|root,arCOG01580@2157|Archaea,2XX3W@28890|Euryarchaeota,2442A@183968|Thermococci	183968|Thermococci	K	Transcriptional regulator	lrpA	-	-	ko:K03718	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
PYH1_k127_4069564_3	1410609.JHVB01000005_gene1318	2.046e-18	87.0	COG1534@1|root,COG1534@2|Bacteria,2J8BU@203691|Spirochaetes	203691|Spirochaetes	J	PFAM CRS1 YhbY (CRM) domain	-	-	-	ko:K07574	-	-	-	-	ko00000,ko03009	-	-	-	CRS1_YhbY
PYH1_k127_4080878_2	386456.JQKN01000017_gene841	1.515e-15	78.0	arCOG12322@1|root,arCOG12322@2157|Archaea,2Y5I1@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_4080878_0	634956.Geoth_0656	2.431e-30	129.0	COG2872@1|root,COG2872@2|Bacteria,1UHS6@1239|Firmicutes,4ISIW@91061|Bacilli	91061|Bacilli	S	Threonyl and Alanyl tRNA synthetase second additional domain	-	-	6.1.1.7	ko:K01872,ko:K07050	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
PYH1_k127_4080878_1	1167006.UWK_02552	1.91e-27	116.0	COG3613@1|root,COG3613@2|Bacteria,1P3XX@1224|Proteobacteria,431PM@68525|delta/epsilon subdivisions,2WWDI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5- phosphate and a purine or pyrimidine base	-	GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009123,GO:0009125,GO:0009159,GO:0009162,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0070694,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	-	-	-	-	-	-	-	-	-	-	Nuc_deoxyrib_tr
PYH1_k127_4085568_4	1343739.PAP_01735	1.842e-08	56.0	COG0091@1|root,arCOG04098@2157|Archaea,2XWGN@28890|Euryarchaeota,243D0@183968|Thermococci	183968|Thermococci	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rpl22	-	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
PYH1_k127_4085568_0	224719.Abm4_1271	3.555e-52	193.0	COG0092@1|root,arCOG04097@2157|Archaea,2XTHR@28890|Euryarchaeota,23NMY@183925|Methanobacteria	183925|Methanobacteria	J	Binds the lower part of the 30S subunit head	rps3	-	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
PYH1_k127_4085568_3	1202768.JROF01000007_gene2697	3.617e-10	63.0	COG0255@1|root,arCOG00785@2157|Archaea,2XZUQ@28890|Euryarchaeota,23WY2@183963|Halobacteria	183963|Halobacteria	J	Belongs to the universal ribosomal protein uL29 family	rpl29	-	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
PYH1_k127_4085568_5	634498.mru_0860	3.09e-07	55.0	COG1588@1|root,arCOG00784@2157|Archaea,2Y0EN@28890|Euryarchaeota,23PQP@183925|Methanobacteria	183925|Methanobacteria	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp1	-	3.1.26.5	ko:K03538	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03016,ko03029	-	-	-	UPF0086
PYH1_k127_4085568_2	351160.RCIX2553	7.236e-34	132.0	COG0186@1|root,arCOG04096@2157|Archaea,2XYPE@28890|Euryarchaeota,2N9XI@224756|Methanomicrobia	224756|Methanomicrobia	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rps17	-	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
PYH1_k127_4085568_1	591019.Shell_1434	1.049e-36	141.0	COG0093@1|root,arCOG04095@2157|Archaea,2XQPU@28889|Crenarchaeota	28889|Crenarchaeota	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rpl14	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0097159,GO:1901363,GO:1990904	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
PYH1_k127_4098659_0	338963.Pcar_1511	5.443e-73	256.0	COG0860@1|root,COG0860@2|Bacteria,1MUQK@1224|Proteobacteria,42MPH@68525|delta/epsilon subdivisions,2WJHW@28221|Deltaproteobacteria,43SCS@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Ami_3	amiC	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	AMIN,Amidase_3,TPR_6
PYH1_k127_4098659_1	237368.SCABRO_01325	1.621e-71	253.0	COG2206@1|root,COG2206@2|Bacteria,2J0TK@203682|Planctomycetes	203682|Planctomycetes	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	HD_5
PYH1_k127_4144090_1	877455.Metbo_2344	5.387e-41	162.0	COG0061@1|root,arCOG01348@2157|Archaea,2XTP6@28890|Euryarchaeota,23NXW@183925|Methanobacteria	183925|Methanobacteria	F	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	Inositol_P,NAD_kinase
PYH1_k127_4144090_2	1183377.Py04_1185	1.068e-27	118.0	COG1439@1|root,arCOG00721@2157|Archaea,2XWH2@28890|Euryarchaeota,2443K@183968|Thermococci	183968|Thermococci	V	ribonuclease activity	nob1	-	-	ko:K07060	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PIN_6
PYH1_k127_4144090_0	309803.CTN_0124	3.021e-49	180.0	COG1131@1|root,COG1131@2|Bacteria	2|Bacteria	V	ATPase activity	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
PYH1_k127_417971_1	267377.MMP1128	8.279e-49	181.0	COG0652@1|root,arCOG04767@2157|Archaea,2XTHC@28890|Euryarchaeota,23RV7@183939|Methanococci	183939|Methanococci	O	PFAM peptidyl-prolyl cis-trans isomerase cyclophilin type	-	-	5.2.1.8	ko:K03768	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Pro_isomerase
PYH1_k127_417971_3	579137.Metvu_0091	5.491e-13	74.0	COG1645@1|root,arCOG00578@2157|Archaea,2Y1BV@28890|Euryarchaeota,23R8R@183939|Methanococci	183939|Methanococci	S	PFAM Sjogrens syndrome scleroderma autoantigen 1	-	-	-	ko:K07143	-	-	-	-	ko00000	-	-	-	Auto_anti-p27
PYH1_k127_417971_2	633148.Tagg_1153	1.352e-36	146.0	COG0125@1|root,arCOG01891@2157|Archaea,2XQB7@28889|Crenarchaeota	28889|Crenarchaeota	F	PFAM thymidylate kinase	tmk	GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
PYH1_k127_417971_0	756883.Halar_3098	1.095e-80	282.0	COG0006@1|root,arCOG01000@2157|Archaea	2157|Archaea	E	Belongs to the peptidase M24B family	-	-	3.4.11.9,3.4.13.9	ko:K01262,ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
PYH1_k127_4188757_2	710687.KI912270_gene2172	6.714e-18	95.0	COG0477@1|root,COG2814@2|Bacteria,2GK1K@201174|Actinobacteria,234ZV@1762|Mycobacteriaceae	201174|Actinobacteria	EGP	Major facilitator superfamily	blt	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
PYH1_k127_4188757_1	1499967.BAYZ01000076_gene753	1.865e-88	297.0	COG0412@1|root,COG0412@2|Bacteria,2NPZG@2323|unclassified Bacteria	2|Bacteria	Q	Dienelactone hydrolase family	dlhH	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
PYH1_k127_4188757_0	1499967.BAYZ01000076_gene754	2.592e-167	533.0	COG0641@1|root,COG0641@2|Bacteria	2|Bacteria	C	radical SAM	aslB	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
PYH1_k127_4240035_0	443254.Marpi_1671	3.42e-14	82.0	COG0358@1|root,COG3579@1|root,COG0358@2|Bacteria,COG3579@2|Bacteria,2GBZ1@200918|Thermotogae	200918|Thermotogae	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	Toprim_2,Toprim_4,Toprim_N,zf-CHC2
PYH1_k127_4240035_1	65393.PCC7424_0560	3.032e-09	63.0	COG0484@1|root,COG0484@2|Bacteria,1G0IY@1117|Cyanobacteria,3KFSU@43988|Cyanothece	1117|Cyanobacteria	J	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
PYH1_k127_4244231_1	644281.MFS40622_0209	6.019e-164	534.0	COG1148@1|root,arCOG02235@2157|Archaea,2XT3X@28890|Euryarchaeota,23QA9@183939|Methanococci	183939|Methanococci	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Pyr_redox_2
PYH1_k127_4244231_0	439481.Aboo_0982	1.611e-208	662.0	COG1053@1|root,arCOG00571@2157|Archaea,2XTK0@28890|Euryarchaeota,3F357@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	FAD binding domain	sdhA	GO:0003674,GO:0003824,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016491,GO:0022900,GO:0044237,GO:0045333,GO:0055114	1.3.4.1,1.3.5.1,1.3.5.4	ko:K00239,ko:K18209	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376,M00620	R02164,R10660	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
PYH1_k127_4244231_2	760568.Desku_1500	2.809e-83	282.0	COG1152@1|root,COG1152@2|Bacteria,1UKJG@1239|Firmicutes,25FYP@186801|Clostridia,26446@186807|Peptococcaceae	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer2_4,Fer4_10,Fer4_9
PYH1_k127_4244231_3	1049564.TevJSym_az00310	1.911e-23	102.0	COG2048@1|root,COG2048@2|Bacteria,1N37J@1224|Proteobacteria,1SBBX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Cysteine-rich domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
PYH1_k127_4301705_0	1408254.T458_08475	1.78e-92	317.0	COG4552@1|root,COG4552@2|Bacteria,1U5C4@1239|Firmicutes,4HF2I@91061|Bacilli	91061|Bacilli	S	Sterol carrier protein domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_9,SCP2_2
PYH1_k127_4301705_1	591019.Shell_0761	2.868e-70	252.0	COG1814@1|root,arCOG01096@2157|Archaea,2XQFK@28889|Crenarchaeota	28889|Crenarchaeota	S	VIT family	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin,VIT1
PYH1_k127_4301705_2	273116.14324441	8.08e-16	90.0	COG0477@1|root,arCOG00130@2157|Archaea,2Y8EG@28890|Euryarchaeota,2424M@183967|Thermoplasmata	183967|Thermoplasmata	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
PYH1_k127_43077_2	1336208.JADY01000009_gene2662	5.617e-14	77.0	COG4570@1|root,COG4570@2|Bacteria	2|Bacteria	L	crossover junction endodeoxyribonuclease activity	rusA	-	3.1.22.4	ko:K01160	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	RusA
PYH1_k127_43077_0	411465.PEPMIC_01688	7.877e-36	145.0	COG0084@1|root,COG0084@2|Bacteria,1TNY1@1239|Firmicutes,248HE@186801|Clostridia,22G6R@1570339|Peptoniphilaceae	186801|Clostridia	L	hydrolase, TatD family	tatD	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
PYH1_k127_43077_1	330779.Saci_0891	1.603e-20	94.0	COG1698@1|root,arCOG04308@2157|Archaea,2XQVN@28889|Crenarchaeota	28889|Crenarchaeota	S	Belongs to the UPF0147 family	-	-	-	ko:K09721	-	-	-	-	ko00000	-	-	-	UPF0147
PYH1_k127_43077_3	1236689.MMALV_04230	1.012e-13	80.0	COG0637@1|root,arCOG02293@2157|Archaea,2Y7X1@28890|Euryarchaeota,3F2UI@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Haloacid dehalogenase-like hydrolase	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
PYH1_k127_4369639_2	565033.GACE_0099	7.164e-58	211.0	arCOG06549@1|root,arCOG06549@2157|Archaea,2Y31C@28890|Euryarchaeota,246R3@183980|Archaeoglobi	183980|Archaeoglobi	C	NapC/NirT cytochrome c family, N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_NNT
PYH1_k127_4369639_3	1163409.UUA_11473	1.977e-13	82.0	COG3005@1|root,COG3005@2|Bacteria,1R4UP@1224|Proteobacteria,1RYPM@1236|Gammaproteobacteria,1XA0Z@135614|Xanthomonadales	135614|Xanthomonadales	C	COG3005 Nitrate TMAO reductases, membrane-bound tetraheme cytochrome c subunit	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,Paired_CXXCH_1
PYH1_k127_4369639_1	1121920.AUAU01000009_gene1859	5.896e-64	229.0	COG0437@1|root,COG0437@2|Bacteria,3Y2Z0@57723|Acidobacteria	57723|Acidobacteria	C	4Fe-4S dicluster domain	-	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	-
PYH1_k127_4369639_0	1379698.RBG1_1C00001G0857	3.18e-75	268.0	COG5557@1|root,COG5557@2|Bacteria,2NNNQ@2323|unclassified Bacteria	1379698.RBG1_1C00001G0857|-	C	Polysulphide reductase, NrfD	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_4408360_1	192952.MM_1745	3.998e-09	60.0	COG0167@1|root,arCOG00603@2157|Archaea,2XTMB@28890|Euryarchaeota,2N9ED@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the conversion of dihydroorotate to orotate	pyrD	-	1.3.1.14	ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
PYH1_k127_4408360_0	694429.Pyrfu_1810	5.18e-70	251.0	COG1498@1|root,arCOG01923@2157|Archaea,2XPYC@28889|Crenarchaeota	28889|Crenarchaeota	J	PFAM Pre-mRNA processing ribonucleoprotein, binding	-	-	-	ko:K14564	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	Nop
PYH1_k127_4413963_0	304371.MCP_0323	1.396e-53	195.0	arCOG12571@1|root,arCOG12571@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_4439885_2	192952.MM_1769	1.183e-05	49.0	COG1943@1|root,arCOG02759@2157|Archaea,2XZF1@28890|Euryarchaeota	28890|Euryarchaeota	L	Transposase IS200 like	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
PYH1_k127_4439885_3	1041930.Mtc_0497	0.0002006	48.0	arCOG05173@1|root,arCOG05173@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_4439885_1	331678.Cphamn1_1252	2.725e-56	200.0	COG3335@1|root,COG3335@2|Bacteria	2|Bacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_32
PYH1_k127_4439885_0	192952.MM_3344	1.651e-109	357.0	arCOG03965@1|root,arCOG03965@2157|Archaea,2Y30I@28890|Euryarchaeota	28890|Euryarchaeota	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3
PYH1_k127_444482_1	765177.Desmu_0529	1.181e-63	229.0	COG1319@1|root,arCOG01926@2157|Archaea,2XQPN@28889|Crenarchaeota	28889|Crenarchaeota	C	CO dehydrogenase flavoprotein domain protein	-	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
PYH1_k127_444482_0	1184251.TCELL_1075	1.479e-274	865.0	COG1529@1|root,arCOG01167@2157|Archaea,2XRR9@28889|Crenarchaeota	28889|Crenarchaeota	C	COGs COG1529 Aerobic-type carbon monoxide dehydrogenase large subunit CoxL CutL homologs	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
PYH1_k127_4464535_0	673860.AciM339_0774	1.982e-117	391.0	COG0303@1|root,arCOG00217@2157|Archaea,2XT2V@28890|Euryarchaeota,3F2ZG@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	TIGRFAM molybdenum cofactor synthesis domain	moeA2	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006464,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0018315,GO:0019538,GO:0019637,GO:0019693,GO:0019720,GO:0032324,GO:0034641,GO:0036211,GO:0042040,GO:0042278,GO:0043170,GO:0043412,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0061598,GO:0061599,GO:0070566,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657	2.10.1.1	ko:K03750,ko:K07219	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N,PBP_like
PYH1_k127_4464535_3	552811.Dehly_0641	8.396e-38	147.0	COG0521@1|root,COG0521@2|Bacteria,2G6YJ@200795|Chloroflexi	200795|Chloroflexi	H	May be involved in the biosynthesis of molybdopterin	-	-	2.7.7.75	ko:K03638	ko00790,ko01100,map00790,map01100	-	R09726	RC00002	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth
PYH1_k127_4464535_2	593117.TGAM_1031	1.65e-48	178.0	COG0315@1|root,arCOG01530@2157|Archaea,2XWHQ@28890|Euryarchaeota,243UY@183968|Thermococci	183968|Thermococci	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
PYH1_k127_4464535_4	593117.TGAM_0172	2.414e-36	142.0	COG0314@1|root,arCOG00534@2157|Archaea,2Y8A9@28890|Euryarchaeota,24465@183968|Thermococci	183968|Thermococci	H	MoaE protein	-	-	2.8.1.12	ko:K03635	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoaE
PYH1_k127_4464535_6	384616.Pisl_0649	7.308e-12	68.0	COG0314@1|root,COG1977@1|root,arCOG00534@2157|Archaea,arCOG00536@2157|Archaea,2XQRK@28889|Crenarchaeota	28889|Crenarchaeota	H	PFAM molybdopterin biosynthesis MoaE	-	-	2.8.1.12	ko:K03635,ko:K21142	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoaE,ThiS
PYH1_k127_4464535_1	195522.BD01_1249	2.343e-88	302.0	COG2896@1|root,arCOG00930@2157|Archaea,2XT7P@28890|Euryarchaeota,242JX@183968|Thermococci	183968|Thermococci	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Mob_synth_C,Radical_SAM
PYH1_k127_4464535_5	589924.Ferp_1649	1.661e-23	104.0	COG2998@1|root,arCOG00229@2157|Archaea,2XUR9@28890|Euryarchaeota,246XU@183980|Archaeoglobi	183980|Archaeoglobi	P	PBP superfamily domain	-	-	-	ko:K05772	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	PBP_like_2
PYH1_k127_4464995_3	694429.Pyrfu_1972	3.847e-42	160.0	COG0099@1|root,arCOG01722@2157|Archaea,2XQBF@28889|Crenarchaeota	28889|Crenarchaeota	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rps13	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
PYH1_k127_4464995_2	399550.Smar_0813	9.11e-45	168.0	COG0522@1|root,arCOG04239@2157|Archaea,2XQCT@28889|Crenarchaeota	28889|Crenarchaeota	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rps4	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
PYH1_k127_4464995_0	1343739.PAP_01895	1.687e-55	196.0	COG0100@1|root,arCOG04240@2157|Archaea,2XX1S@28890|Euryarchaeota,243ZQ@183968|Thermococci	183968|Thermococci	J	Located on the platform of the 30S subunit	rps11	GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
PYH1_k127_4464995_1	572546.Arcpr_1028	2.314e-49	188.0	COG0202@1|root,arCOG04241@2157|Archaea,2XTQB@28890|Euryarchaeota,246MA@183980|Archaeoglobi	183980|Archaeoglobi	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoD	-	2.7.7.6	ko:K03047	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	Fer4,RNA_pol_A_bac,RNA_pol_L
PYH1_k127_4464995_4	633148.Tagg_1393	1.247e-22	102.0	COG1727@1|root,arCOG00780@2157|Archaea,2XQV1@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eL18 family	rpl18e	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02883	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18,Ribosomal_L27A
PYH1_k127_4474777_2	1121324.CLIT_2c00440	1.142e-09	65.0	COG1433@1|root,COG1433@2|Bacteria,1V7KS@1239|Firmicutes,24J98@186801|Clostridia,25U7C@186804|Peptostreptococcaceae	186801|Clostridia	S	Putative redox-active protein (C_GCAxxG_C_C)	-	-	-	-	-	-	-	-	-	-	-	-	C_GCAxxG_C_C
PYH1_k127_4474777_0	266265.Bxe_C1239	1.051e-86	297.0	COG0613@1|root,COG0613@2|Bacteria,1QY4S@1224|Proteobacteria	1224|Proteobacteria	S	PHP domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_4474777_1	266265.Bxe_C1239	5.438e-64	226.0	COG0613@1|root,COG0613@2|Bacteria,1QY4S@1224|Proteobacteria	1224|Proteobacteria	S	PHP domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_4541075_0	309800.C498_12073	1.121e-121	417.0	COG1201@1|root,arCOG00557@2157|Archaea,2XSTH@28890|Euryarchaeota,23S50@183963|Halobacteria	183963|Halobacteria	K	DEAD H associated	lhr1	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
PYH1_k127_4541075_1	1459636.NTE_01749	2.183e-59	220.0	COG1819@1|root,arCOG01393@2157|Archaea,41SZK@651137|Thaumarchaeota	651137|Thaumarchaeota	G	Glycosyl transferase family 1	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_4541075_2	391623.TERMP_01620	3.23e-58	209.0	COG2078@1|root,arCOG01336@2157|Archaea,2XUAP@28890|Euryarchaeota,242T1@183968|Thermococci	183968|Thermococci	S	AMMECR1	-	-	-	ko:K09141	-	-	-	-	ko00000	-	-	-	AMMECR1
PYH1_k127_4541075_3	694429.Pyrfu_0407	3.396e-36	142.0	COG1656@1|root,arCOG04290@2157|Archaea,2XQD5@28889|Crenarchaeota	28889|Crenarchaeota	S	Mut7-C RNAse domain	-	-	-	ko:K09122	-	-	-	-	ko00000	-	-	-	Mut7-C
PYH1_k127_4541075_4	243232.MJ_0653	5.989e-28	120.0	COG0517@1|root,arCOG00606@2157|Archaea,2XX11@28890|Euryarchaeota,23QUR@183939|Methanococci	183939|Methanococci	S	PFAM CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS
PYH1_k127_458940_0	1220534.B655_1297	2.44e-63	229.0	arCOG12322@1|root,arCOG12322@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_458940_1	1408254.T458_09995	1.31e-54	198.0	COG2362@1|root,COG2362@2|Bacteria,1TSUZ@1239|Firmicutes,4HC5R@91061|Bacilli,26VQD@186822|Paenibacillaceae	1239|Firmicutes	E	D-aminopeptidase	-	-	-	ko:K16203	-	-	-	-	ko00000,ko01000,ko01002	3.A.1.5.2	-	-	Peptidase_M55
PYH1_k127_463914_2	868131.MSWAN_0068	1.107e-83	282.0	COG2509@1|root,arCOG02231@2157|Archaea,2XTVH@28890|Euryarchaeota	28890|Euryarchaeota	S	FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	-	ko:K07137	-	-	-	-	ko00000	-	-	-	FAD_binding_2,FAD_binding_3,GIDA,HI0933_like,Pyr_redox_2,Thi4
PYH1_k127_463914_6	339860.Msp_1335	8.817e-26	109.0	COG0361@1|root,arCOG01179@2157|Archaea,2XXX0@28890|Euryarchaeota,23P26@183925|Methanobacteria	183925|Methanobacteria	J	Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits	eif1a	-	-	ko:K03236	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	eIF-1a
PYH1_k127_463914_5	1365176.N186_03270	1.208e-27	113.0	COG2163@1|root,arCOG04167@2157|Archaea,2XQT9@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eL14 family	rpl14e	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02875	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14e
PYH1_k127_463914_3	399550.Smar_1045	1.04e-37	148.0	COG1102@1|root,arCOG01037@2157|Archaea,2XQ8J@28889|Crenarchaeota	28889|Crenarchaeota	F	Belongs to the cytidylate kinase family. Type 2 subfamily	cmk	-	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin2
PYH1_k127_463914_8	1220534.B655_1487	5.923e-10	67.0	COG1422@1|root,arCOG02673@2157|Archaea,2XSX8@28890|Euryarchaeota,23P4B@183925|Methanobacteria	183925|Methanobacteria	U	Integral membrane protein DUF106	-	-	-	-	-	-	-	-	-	-	-	-	DUF106
PYH1_k127_463914_0	186497.PF2000	1.853e-186	595.0	COG1003@1|root,arCOG00076@2157|Archaea,2XT3V@28890|Euryarchaeota,242MV@183968|Thermococci	183968|Thermococci	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPB	-	1.4.4.2	ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
PYH1_k127_463914_1	1343739.PAP_02650	3.053e-143	467.0	COG0403@1|root,arCOG00077@2157|Archaea,2XT39@28890|Euryarchaeota,242SE@183968|Thermococci	183968|Thermococci	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPA	-	1.4.4.2	ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
PYH1_k127_463914_7	1121440.AUMA01000016_gene154	3.295e-10	63.0	COG1146@1|root,COG1146@2|Bacteria	2|Bacteria	C	4 iron, 4 sulfur cluster binding	MA20_14855	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4,Fer4_7
PYH1_k127_463914_4	1209989.TepiRe1_0750	6.002e-32	130.0	COG2222@1|root,COG2222@2|Bacteria,1TRBS@1239|Firmicutes,24A9W@186801|Clostridia,42EVQ@68295|Thermoanaerobacterales	186801|Clostridia	G	TIGRFAM bifunctional phosphoglucose phosphomannose isomerase	-	-	5.3.1.8,5.3.1.9	ko:K15916	ko00010,ko00030,ko00051,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R01819,R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	SIS,bact-PGI_C
PYH1_k127_4658110_1	374847.Kcr_0537	4.385e-14	73.0	arCOG09435@1|root,arCOG09435@2157|Archaea	374847.Kcr_0537|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_4658110_0	1047013.AQSP01000140_gene2497	6.48e-169	546.0	COG2866@1|root,COG2866@2|Bacteria,2NQNH@2323|unclassified Bacteria	2|Bacteria	E	Zinc carboxypeptidase	-	-	-	ko:K14054	-	-	-	-	ko00000	-	-	-	AstE_AspA,Peptidase_M14
PYH1_k127_466205_2	255470.cbdbA1487	3.018e-09	58.0	COG2801@1|root,COG2801@2|Bacteria,2G8GQ@200795|Chloroflexi,34DDP@301297|Dehalococcoidia	301297|Dehalococcoidia	L	PFAM Integrase catalytic region	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
PYH1_k127_466205_0	552811.Dehly_1282	1.044e-48	179.0	COG0071@1|root,COG0071@2|Bacteria,2G71M@200795|Chloroflexi,34D60@301297|Dehalococcoidia	301297|Dehalococcoidia	O	Hsp20/alpha crystallin family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
PYH1_k127_466205_1	1295642.H839_05424	3.488e-12	68.0	COG0789@1|root,COG0789@2|Bacteria,1V6JE@1239|Firmicutes,4HKM6@91061|Bacilli,1WGCA@129337|Geobacillus	91061|Bacilli	K	helix_turn_helix, mercury resistance	glnR	GO:0003674,GO:0005488,GO:0005515,GO:0006082,GO:0006355,GO:0006520,GO:0006541,GO:0006542,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0016053,GO:0019219,GO:0019222,GO:0019752,GO:0031323,GO:0031326,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1903506,GO:2000112,GO:2001141	-	ko:K03713,ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000,ko03000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	MerR_1
PYH1_k127_474168_0	1120973.AQXL01000083_gene2908	2.172e-121	404.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1TR2N@1239|Firmicutes,4H9RR@91061|Bacilli	91061|Bacilli	EU	peptidase	yuxL	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
PYH1_k127_4761544_2	342949.PNA2_0186	1.403e-18	89.0	COG2023@1|root,arCOG04345@2157|Archaea,2XYX0@28890|Euryarchaeota,244AW@183968|Thermococci	183968|Thermococci	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp4	GO:0000966,GO:0001682,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0032991,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1902555,GO:1905348,GO:1990904	3.1.26.5	ko:K03540	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Rpr2
PYH1_k127_4761544_0	420247.Msm_0801	9.554e-53	199.0	COG1798@1|root,arCOG04161@2157|Archaea,2XV63@28890|Euryarchaeota,23NX5@183925|Methanobacteria	183925|Methanobacteria	J	S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF- 2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis	dphB	-	2.1.1.98	ko:K20215	-	-	R04481,R08468,R08469,R10306	RC00003,RC00190,RC01155,RC02136,RC02308	ko00000,ko01000	-	-	-	TP_methylase
PYH1_k127_4761544_3	384616.Pisl_0687	2.447e-06	59.0	COG0615@1|root,COG1849@1|root,arCOG01222@2157|Archaea,arCOG01224@2157|Archaea,2XQ8K@28889|Crenarchaeota	28889|Crenarchaeota	M	TIGRFAM cytidyltransferase-related domain	-	-	2.7.7.2	ko:K14656	ko00740,ko01100,ko01110,map00740,map01100,map01110	-	R00161	RC00002	ko00000,ko00001,ko01000	-	-	-	CTP_transf_like,DUF357
PYH1_k127_4761544_1	386456.JQKN01000002_gene2603	4.346e-27	115.0	COG0615@1|root,arCOG01222@2157|Archaea,2XX70@28890|Euryarchaeota,23P3H@183925|Methanobacteria	183925|Methanobacteria	F	Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme	ribL	-	2.7.7.2	ko:K14656	ko00740,ko01100,ko01110,map00740,map01100,map01110	-	R00161	RC00002	ko00000,ko00001,ko01000	-	-	-	CTP_transf_like
PYH1_k127_4877761_1	290315.Clim_1767	0.0002091	52.0	COG0463@1|root,COG0463@2|Bacteria,1FDBQ@1090|Chlorobi	1090|Chlorobi	M	PFAM glycosyl transferase family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
PYH1_k127_4877761_0	768710.DesyoDRAFT_0541	7.433e-06	56.0	COG0471@1|root,COG0471@2|Bacteria,1TSGE@1239|Firmicutes,2590S@186801|Clostridia,2623Z@186807|Peptococcaceae	186801|Clostridia	P	TIGRFAM anion transporter	-	-	-	ko:K03319,ko:K11106	-	-	-	-	ko00000,ko02000	2.A.47,2.A.47.3.3	-	-	Na_sulph_symp
PYH1_k127_494635_2	666510.ASAC_0527	4.449e-06	53.0	arCOG06011@1|root,arCOG06011@2157|Archaea,2XR5I@28889|Crenarchaeota	28889|Crenarchaeota	S	Domain of unknown function (DUF4382)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4382
PYH1_k127_494635_0	1459636.NTE_00236	6.23e-13	73.0	arCOG09752@1|root,arCOG09752@2157|Archaea,41T9M@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_494635_1	1459636.NTE_01305	3.752e-12	76.0	arCOG02809@1|root,arCOG02809@2157|Archaea	2157|Archaea	V	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5
PYH1_k127_496174_2	264732.Moth_0439	8.724e-23	104.0	COG1150@1|root,COG1150@2|Bacteria,1V8UM@1239|Firmicutes,24J4U@186801|Clostridia,42GMS@68295|Thermoanaerobacterales	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03390	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_8
PYH1_k127_496174_1	429009.Adeg_2015	3.934e-58	205.0	COG1908@1|root,COG1908@2|Bacteria,1V7I6@1239|Firmicutes,24JV2@186801|Clostridia,42GG4@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM methyl-viologen-reducing hydrogenase delta subunit	-	-	1.8.98.5,1.8.98.6	ko:K14127	ko00680,map00680	-	R00019,R11943,R11944	RC00011	ko00000,ko00001,ko01000	-	-	-	FlpD,NADH_4Fe-4S
PYH1_k127_496174_0	429009.Adeg_1885	6.26e-104	346.0	COG1148@1|root,COG1148@2|Bacteria,1V5YJ@1239|Firmicutes,248CC@186801|Clostridia,42FJG@68295|Thermoanaerobacterales	186801|Clostridia	C	4Fe-4S ferredoxin, iron-sulfur binding	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Pyr_redox_2
PYH1_k127_4974147_1	891974.E05_29760	3.039e-20	93.0	COG0860@1|root,COG1388@1|root,COG0860@2|Bacteria,COG1388@2|Bacteria,1MUQK@1224|Proteobacteria,1RMP1@1236|Gammaproteobacteria,282P1@191675|unclassified Enterobacteriaceae	1236|Gammaproteobacteria	M	N-acetylmuramoyl-L-alanine amidase	amiB	GO:0000003,GO:0000910,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0007049,GO:0008150,GO:0008745,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0019954,GO:0022402,GO:0022414,GO:0030288,GO:0030313,GO:0031975,GO:0032505,GO:0042597,GO:0043093,GO:0044464,GO:0051301,GO:0061783	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	iG2583_1286.G2583_4996	AMIN,Amidase_3,LysM
PYH1_k127_4974147_0	945713.IALB_1750	1.31e-139	452.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	CarbopepD_reg_2,Plug,TonB_dep_Rec
PYH1_k127_4981920_0	1041930.Mtc_2093	2.911e-87	295.0	COG1131@1|root,arCOG00194@2157|Archaea,2XT7Q@28890|Euryarchaeota	28890|Euryarchaeota	E	ABC-type multidrug transport system, ATPase component	trp2	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
PYH1_k127_5052724_1	931626.Awo_c14850	2.089e-35	141.0	COG0330@1|root,COG0330@2|Bacteria,1TPXU@1239|Firmicutes,248MP@186801|Clostridia,25VEF@186806|Eubacteriaceae	186801|Clostridia	O	SPFH Band 7 PHB domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
PYH1_k127_5052724_2	309807.SRU_1840	6.905e-14	81.0	COG0668@1|root,COG0668@2|Bacteria,4NEPW@976|Bacteroidetes,1FIQE@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	M	Mechanosensitive ion channel	-	-	-	ko:K16052	-	-	-	-	ko00000,ko02000	1.A.23.4	-	-	MS_channel
PYH1_k127_5052724_0	1229909.NSED_03055	7.2e-71	254.0	COG0475@1|root,arCOG01953@2157|Archaea,41T00@651137|Thaumarchaeota	651137|Thaumarchaeota	P	Sodium hydrogen exchanger	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
PYH1_k127_5068000_2	1379698.RBG1_1C00001G1078	3.016e-10	65.0	COG2318@1|root,COG2318@2|Bacteria	2|Bacteria	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
PYH1_k127_5068000_3	1123277.KB893189_gene5261	4.675e-06	49.0	COG2318@1|root,COG2318@2|Bacteria,4NRAP@976|Bacteroidetes,47NZT@768503|Cytophagia	976|Bacteroidetes	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
PYH1_k127_5068000_0	70601.3256625	1.385e-36	145.0	COG3273@1|root,arCOG01963@2157|Archaea,2XSXK@28890|Euryarchaeota,243HR@183968|Thermococci	183968|Thermococci	P	TrkA-C domain	-	-	-	-	-	-	-	-	-	-	-	-	PhoU,TrkA_C
PYH1_k127_5068000_1	673860.AciM339_0073	1.02e-29	125.0	COG3273@1|root,arCOG01963@2157|Archaea,2XSXK@28890|Euryarchaeota,3F2NX@33867|unclassified Euryarchaeota	28890|Euryarchaeota	P	PhoU domain	pchB	-	-	-	-	-	-	-	-	-	-	-	PhoU,TrkA_C
PYH1_k127_5122807_2	368408.Tpen_1350	9.151e-23	99.0	COG1473@1|root,arCOG01108@2157|Archaea,2XRII@28889|Crenarchaeota	28889|Crenarchaeota	E	carboxypeptidase activity	-	-	-	ko:K12941,ko:K13048	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
PYH1_k127_5122807_0	368408.Tpen_0427	3.46e-130	433.0	COG1793@1|root,arCOG01347@2157|Archaea,2XPV8@28889|Crenarchaeota	28889|Crenarchaeota	L	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair	-	-	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N
PYH1_k127_5122807_1	1365176.N186_03140	3.336e-96	325.0	COG0258@1|root,arCOG04050@2157|Archaea,2XPRH@28889|Crenarchaeota	28889|Crenarchaeota	L	Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into	-	-	-	ko:K04799	ko03030,ko03410,ko03450,map03030,map03410,map03450	-	-	-	ko00000,ko00001,ko01000,ko03032,ko03400,ko04147	-	-	-	XPG_I,XPG_N
PYH1_k127_5176313_0	1449126.JQKL01000015_gene2945	9.493e-161	519.0	COG0519@1|root,COG0519@2|Bacteria,1TPG8@1239|Firmicutes,2487F@186801|Clostridia,267WX@186813|unclassified Clostridiales	186801|Clostridia	F	Catalyzes the synthesis of GMP from XMP	guaA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase,tRNA_Me_trans
PYH1_k127_5204177_1	1105031.HMPREF1141_1625	1.963e-08	66.0	COG2309@1|root,COG2309@2|Bacteria,1UMYG@1239|Firmicutes,24BYI@186801|Clostridia,36HXE@31979|Clostridiaceae	186801|Clostridia	E	Thermophilic metalloprotease (M29)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M29
PYH1_k127_5204177_0	1320556.AVBP01000010_gene3280	6.404e-31	135.0	COG2855@1|root,COG2855@2|Bacteria,1MVIP@1224|Proteobacteria,2TVK9@28211|Alphaproteobacteria,43HQF@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	membrane	yeiH	-	-	-	-	-	-	-	-	-	-	-	Cons_hypoth698
PYH1_k127_5204230_2	384616.Pisl_2001	1.569e-09	66.0	COG0640@1|root,arCOG03859@2157|Archaea,2XR12@28889|Crenarchaeota	28889|Crenarchaeota	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
PYH1_k127_5204230_1	1391646.AVSU01000032_gene2289	3.639e-28	120.0	COG4122@1|root,COG4122@2|Bacteria,1UF4M@1239|Firmicutes,24B70@186801|Clostridia,25ST0@186804|Peptostreptococcaceae	186801|Clostridia	S	O-methyltransferase	yrrM	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_3
PYH1_k127_5204230_0	604331.AUHY01000054_gene1204	3.639e-91	310.0	COG3191@1|root,COG3191@2|Bacteria,1WJKZ@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	EQ	PFAM peptidase S58 DmpA	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S58
PYH1_k127_5204770_1	760568.Desku_0877	4.607e-11	67.0	COG2411@1|root,COG2411@2|Bacteria	2|Bacteria	-	-	-	-	3.5.4.5	ko:K01489	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01878,R02485,R08221	RC00074,RC00514	ko00000,ko00001,ko01000	-	-	-	ASCH
PYH1_k127_5204770_0	1459636.NTE_02288	4.619e-75	265.0	COG4046@1|root,arCOG04181@2157|Archaea,41S8T@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Protein of unknown function (DUF1512)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1512
PYH1_k127_526694_1	1120973.AQXL01000117_gene343	4.008e-09	63.0	2F6QX@1|root,33Z76@2|Bacteria,1VY7H@1239|Firmicutes,4HWZV@91061|Bacilli,27A4C@186823|Alicyclobacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_526694_0	1220534.B655_0237	4.461e-91	302.0	arCOG06481@1|root,arCOG06481@2157|Archaea,2XV5Y@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_5281406_0	311424.DhcVS_763	3.652e-137	452.0	COG1009@1|root,COG1009@2|Bacteria,2G67I@200795|Chloroflexi,34CQ1@301297|Dehalococcoidia	301297|Dehalococcoidia	CP	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus	echA	-	-	ko:K14086	-	-	-	-	ko00000	-	-	-	Proton_antipo_M,Proton_antipo_N
PYH1_k127_529067_0	69014.TK1708	7.738e-105	349.0	COG0451@1|root,arCOG01369@2157|Archaea,2XTRS@28890|Euryarchaeota,242JW@183968|Thermococci	183968|Thermococci	M	NAD(P)H-binding	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
PYH1_k127_529960_3	1459636.NTE_02760	1.574e-76	263.0	COG0012@1|root,arCOG00357@2157|Archaea,41S71@651137|Thaumarchaeota	651137|Thaumarchaeota	J	GTPase of unknown function C-terminal	-	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,MMR_HSR1_C,TGS
PYH1_k127_529960_6	342949.PNA2_0184	7.521e-15	79.0	COG4003@1|root,arCOG05763@2157|Archaea,2Y3NV@28890|Euryarchaeota,2446V@183968|Thermococci	183968|Thermococci	S	Uncharacterized protein conserved in archaea (DUF2095)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2095
PYH1_k127_529960_0	420247.Msm_0655	1.363e-123	409.0	COG1208@1|root,arCOG00666@2157|Archaea,2XT8U@28890|Euryarchaeota,23NRH@183925|Methanobacteria	183925|Methanobacteria	M	Bacterial transferase hexapeptide repeat	-	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
PYH1_k127_529960_2	634498.mru_0458	9.74e-94	323.0	COG1109@1|root,arCOG00767@2157|Archaea,2XT1X@28890|Euryarchaeota,23NRF@183925|Methanobacteria	183925|Methanobacteria	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	-	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
PYH1_k127_529960_5	886293.Sinac_4909	1.962e-15	84.0	COG2413@1|root,COG2413@2|Bacteria,2J523@203682|Planctomycetes	203682|Planctomycetes	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	-	-	-	-	-	-	-	-	-	HD
PYH1_k127_529960_4	391623.TERMP_00899	3.922e-53	193.0	COG1890@1|root,arCOG04186@2157|Archaea,2XSX9@28890|Euryarchaeota,242YU@183968|Thermococci	183968|Thermococci	J	Belongs to the eukaryotic ribosomal protein eS1 family	rps3ae	GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576	-	ko:K02984	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S3Ae
PYH1_k127_529960_7	439481.Aboo_0449	1.378e-05	50.0	arCOG01354@1|root,arCOG01354@2157|Archaea,2Y76E@28890|Euryarchaeota,3F3GU@33867|unclassified Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_529960_1	439481.Aboo_1116	2.691e-94	326.0	COG0608@1|root,arCOG00427@2157|Archaea,2XT8Y@28890|Euryarchaeota,3F2FV@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	DHHA1 domain	recJ	-	-	ko:K07463	-	-	-	-	ko00000	-	-	-	DHHA1
PYH1_k127_5307575_0	574087.Acear_1401	1.028e-107	360.0	COG1032@1|root,COG1032@2|Bacteria,1UZQC@1239|Firmicutes,24PDA@186801|Clostridia	186801|Clostridia	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
PYH1_k127_5307575_1	1121878.AUGL01000001_gene233	3.141e-06	53.0	COG4885@1|root,COG4885@2|Bacteria,1R65B@1224|Proteobacteria,1RWBY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,Cytochrome_CBB3
PYH1_k127_5307777_1	443254.Marpi_0537	2.338e-62	229.0	COG1164@1|root,COG1164@2|Bacteria,2GCJ4@200918|Thermotogae	200918|Thermotogae	E	PFAM peptidase M3A and M3B thimet oligopeptidase F	-	-	-	ko:K08602	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3,Peptidase_M3_N
PYH1_k127_5307777_3	374847.Kcr_0315	4.173e-30	135.0	COG0477@1|root,arCOG00130@2157|Archaea	2157|Archaea	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3,Sugar_tr
PYH1_k127_5307777_2	572546.Arcpr_0981	1.227e-34	137.0	COG0195@1|root,arCOG01760@2157|Archaea,2XYAY@28890|Euryarchaeota,2468I@183980|Archaeoglobi	183980|Archaeoglobi	K	Participates in transcription termination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_2
PYH1_k127_5307777_4	523845.AQXV01000054_gene1664	2.177e-25	108.0	COG1911@1|root,arCOG01752@2157|Archaea,2Y0CU@28890|Euryarchaeota,23R1G@183939|Methanococci	183939|Methanococci	J	Belongs to the eukaryotic ribosomal protein eL30 family	rpl30e	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02908	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L7Ae
PYH1_k127_5307777_0	1459636.NTE_02749	0.0	1195.0	COG0086@1|root,arCOG04256@2157|Archaea,arCOG04257@2157|Archaea,41SB2@651137|Thaumarchaeota	651137|Thaumarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA2	-	2.7.7.6	ko:K03041	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
PYH1_k127_530988_0	257310.BB2360	1.39e-53	194.0	COG0624@1|root,COG0624@2|Bacteria,1MVBR@1224|Proteobacteria,2VK9D@28216|Betaproteobacteria	28216|Betaproteobacteria	E	Peptidase M20	-	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
PYH1_k127_530988_1	646529.Desaci_2972	1.435e-46	175.0	COG2871@1|root,COG3894@1|root,COG2871@2|Bacteria,COG3894@2|Bacteria,1TP0H@1239|Firmicutes,247S0@186801|Clostridia,260DA@186807|Peptococcaceae	186801|Clostridia	C	PFAM 2Fe-2S iron-sulfur cluster binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
PYH1_k127_5318060_0	572478.Vdis_0925	1.334e-50	193.0	COG1201@1|root,arCOG00557@2157|Archaea,2XPNI@28889|Crenarchaeota	28889|Crenarchaeota	L	DEAD DEAH box helicase domain protein	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
PYH1_k127_5318060_1	1449126.JQKL01000023_gene212	7.102e-39	153.0	COG4126@1|root,COG4126@2|Bacteria,1TT35@1239|Firmicutes,24KAI@186801|Clostridia	186801|Clostridia	E	Psort location Cytoplasmic, score 8.87	-	-	-	ko:K14591	-	-	-	-	ko00000	-	-	-	AroM
PYH1_k127_5318060_2	579137.Metvu_0978	8.451e-30	125.0	COG0293@1|root,arCOG00079@2157|Archaea,2XT12@28890|Euryarchaeota,23QIM@183939|Methanococci	183939|Methanococci	J	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit	rlmE	GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0009451,GO:0009987,GO:0016070,GO:0016740,GO:0016741,GO:0032259,GO:0034641,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:1901360	2.1.1.166	ko:K02427	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ
PYH1_k127_535288_0	1408473.JHXO01000008_gene2863	5.045e-115	378.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	ko:K08218	ko01501,map01501	M00628	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.25	-	-	MFS_1
PYH1_k127_537505_0	589924.Ferp_0652	7.153e-43	168.0	COG0123@1|root,arCOG00324@2157|Archaea,2XT0B@28890|Euryarchaeota,246V5@183980|Archaeoglobi	183980|Archaeoglobi	BQ	PFAM histone deacetylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
PYH1_k127_537505_1	192952.MM_1628	1.434e-42	161.0	COG0717@1|root,arCOG04048@2157|Archaea,2XVHA@28890|Euryarchaeota,2NBIR@224756|Methanomicrobia	224756|Methanomicrobia	F	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA	dut	-	3.6.1.23	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00053	R02100,R11896	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	dUTPase
PYH1_k127_538596_0	1382304.JNIL01000001_gene3479	1.108e-117	390.0	COG2355@1|root,COG2355@2|Bacteria,1TRNQ@1239|Firmicutes,4HEBU@91061|Bacilli	91061|Bacilli	E	Membrane dipeptidase (Peptidase family M19)	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
PYH1_k127_538596_2	1410628.JNKS01000011_gene2605	3.386e-08	61.0	COG2189@1|root,COG2189@2|Bacteria,1TXPT@1239|Firmicutes,24DWS@186801|Clostridia,27JI8@186928|unclassified Lachnospiraceae	186801|Clostridia	L	Belongs to the N(4) N(6)-methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_538596_1	192952.MM_0252	1.542e-09	61.0	COG3432@1|root,arCOG01055@2157|Archaea,2Y23V@28890|Euryarchaeota,2NBDP@224756|Methanomicrobia	224756|Methanomicrobia	K	Winged helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HTH_45
PYH1_k127_538596_3	1449357.JQLK01000001_gene1708	0.000718	48.0	COG0589@1|root,COG0589@2|Bacteria,1WK0S@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
PYH1_k127_5404457_2	523841.HFX_1542	7.517e-06	48.0	COG1405@1|root,arCOG01981@2157|Archaea,2XT0Z@28890|Euryarchaeota,23S2M@183963|Halobacteria	183963|Halobacteria	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	tfb5	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
PYH1_k127_5404457_1	673860.AciM339_1397	2.726e-24	108.0	COG1051@1|root,COG2005@1|root,arCOG00223@2157|Archaea,arCOG01075@2157|Archaea,2XXS4@28890|Euryarchaeota,3F39U@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
PYH1_k127_5404457_0	479434.Sthe_1187	6.832e-158	519.0	COG1132@1|root,COG1132@2|Bacteria,2G66A@200795|Chloroflexi,27Z0P@189775|Thermomicrobia	189775|Thermomicrobia	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
PYH1_k127_5404457_3	476272.RUMHYD_01652	7.062e-05	45.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia,3Y121@572511|Blautia	186801|Clostridia	V	Psort location CytoplasmicMembrane, score 9.99	-	-	-	ko:K06147,ko:K18888	ko02010,map02010	M00706	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
PYH1_k127_5408068_0	240292.Ava_1378	1.348e-19	98.0	2BDP7@1|root,327CQ@2|Bacteria,1GCJ7@1117|Cyanobacteria,1HMVV@1161|Nostocales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_5408068_1	1379698.RBG1_1C00001G0125	3.988e-07	56.0	2EGJW@1|root,3110Q@2|Bacteria,2NS2A@2323|unclassified Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_5409346_1	504728.K649_06060	1.512e-10	68.0	2CAQ4@1|root,33YR3@2|Bacteria,1WMW6@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_5409346_0	269797.Mbar_A0214	1.184e-72	258.0	COG1363@1|root,arCOG01518@2157|Archaea,2XT3M@28890|Euryarchaeota,2N94F@224756|Methanomicrobia	224756|Methanomicrobia	G	peptidase M42 family protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M42
PYH1_k127_5427921_2	1041930.Mtc_1660	1.665e-09	59.0	COG0265@1|root,arCOG02833@2157|Archaea,2XT7Y@28890|Euryarchaeota,2NAWS@224756|Methanomicrobia	224756|Methanomicrobia	O	Trypsin	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
PYH1_k127_5427921_0	1303518.CCALI_00142	5.549e-50	189.0	COG0265@1|root,COG0265@2|Bacteria	2|Bacteria	O	serine-type endopeptidase activity	MA20_17565	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
PYH1_k127_5427921_1	1459636.NTE_03333	2.655e-21	101.0	COG1733@1|root,arCOG01057@2157|Archaea	2157|Archaea	K	Transcriptional regulator	-	-	-	ko:K07332	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	-
PYH1_k127_5437579_1	877455.Metbo_0169	3.071e-125	411.0	COG0065@1|root,arCOG01698@2157|Archaea,2XTWH@28890|Euryarchaeota,23PD9@183925|Methanobacteria	183925|Methanobacteria	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
PYH1_k127_5437579_3	589924.Ferp_2125	1.115e-48	178.0	COG0066@1|root,arCOG02230@2157|Archaea,2XTXJ@28890|Euryarchaeota,2465I@183980|Archaeoglobi	183980|Archaeoglobi	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	-	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
PYH1_k127_5437579_2	420247.Msm_0373	1.717e-104	349.0	COG0473@1|root,arCOG01163@2157|Archaea,2XT99@28890|Euryarchaeota,23NNW@183925|Methanobacteria	183925|Methanobacteria	C	Isocitrate isopropylmalate dehydrogenase	aksF	-	1.1.1.87	ko:K10978	ko00300,ko00680,ko01100,ko01120,ko01130,ko01210,ko01230,map00300,map00680,map01100,map01120,map01130,map01210,map01230	M00608	R01934,R01936,R04862,R08214,R08215	RC00084,RC00114,RC00626	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
PYH1_k127_5437579_5	1229909.NSED_07145	3.01e-10	62.0	arCOG01588@1|root,arCOG01588@2157|Archaea,41SVX@651137|Thaumarchaeota	651137|Thaumarchaeota	E	lysine biosynthesis protein LysW	-	-	-	ko:K05826	-	M00031,M00763	-	-	ko00000,ko00001,ko00002	-	-	-	-
PYH1_k127_5437579_6	573064.Mefer_1229	7.942e-08	64.0	COG0189@1|root,arCOG01589@2157|Archaea,2XVAI@28890|Euryarchaeota,23QFS@183939|Methanococci	183939|Methanococci	H	RimK domain protein ATP-grasp	cofF	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016874,GO:0016879,GO:0016881,GO:0043774,GO:0044424,GO:0044464	6.3.2.32	ko:K14940	ko00680,ko01120,map00680,map01120	-	R09401	RC00064,RC00090	ko00000,ko00001,ko01000	-	-	-	RimK
PYH1_k127_5437579_0	1131266.ARWQ01000004_gene1453	2.08e-125	410.0	COG0002@1|root,arCOG00495@2157|Archaea,41S8R@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily	lysY	-	-	ko:K05829	ko00220,ko00300,ko01100,ko01110,ko01210,ko01230,map00220,map00300,map01100,map01110,map01210,map01230	M00031,M00763	R09777,R10931	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
PYH1_k127_5437579_4	1229909.NSED_07160	2.298e-47	175.0	COG0548@1|root,arCOG00862@2157|Archaea,41SFB@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis)	lysZ	-	-	ko:K05828	ko00220,ko00300,ko01100,ko01110,ko01210,ko01230,map00220,map00300,map01100,map01110,map01210,map01230	M00031,M00763	R09776,R10930	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
PYH1_k127_5453384_1	523850.TON_0798	1.264e-54	200.0	COG0452@1|root,arCOG01704@2157|Archaea,2XTZK@28890|Euryarchaeota,242ZD@183968|Thermococci	183968|Thermococci	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	-	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
PYH1_k127_5453384_0	374847.Kcr_1287	3.048e-72	259.0	COG2262@1|root,arCOG00353@2157|Archaea	2157|Archaea	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0043021,GO:0043022,GO:0044424,GO:0044464,GO:0044877	-	ko:K03665,ko:K06883	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
PYH1_k127_5453384_2	671065.MetMK1DRAFT_00030280	3.327e-08	58.0	COG0177@1|root,arCOG00459@2157|Archaea,2XQK9@28889|Crenarchaeota	28889|Crenarchaeota	L	PFAM HhH-GPD family protein	-	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
PYH1_k127_5471324_0	224325.AF_0252	1.77e-131	430.0	COG0504@1|root,arCOG00063@2157|Archaea,2XTR2@28890|Euryarchaeota,245WV@183980|Archaeoglobi	183980|Archaeoglobi	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
PYH1_k127_5471324_1	368408.Tpen_0618	6.48e-84	282.0	COG0005@1|root,arCOG01327@2157|Archaea,2XPU0@28889|Crenarchaeota	28889|Crenarchaeota	F	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates	mtnP	-	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
PYH1_k127_548795_0	387631.Asulf_02299	8.041e-69	243.0	COG4231@1|root,arCOG01609@2157|Archaea,2XUNR@28890|Euryarchaeota,246UD@183980|Archaeoglobi	183980|Archaeoglobi	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	-	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,POR_N,TPP_enzyme_C
PYH1_k127_548795_1	391623.TERMP_01314	5.705e-42	161.0	COG1014@1|root,arCOG01602@2157|Archaea,2XXK2@28890|Euryarchaeota,242YZ@183968|Thermococci	183968|Thermococci	C	Indolepyruvate ferredoxin oxidoreductase subunit	iorB-1	-	1.2.7.8	ko:K00180	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR
PYH1_k127_548795_2	1313172.YM304_08520	3.468e-38	147.0	COG1071@1|root,COG1071@2|Bacteria,2HFTJ@201174|Actinobacteria,4CNQW@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Dehydrogenase E1 component	-	-	-	ko:K21416	-	-	-	-	ko00000,ko01000	-	-	-	E1_dh
PYH1_k127_5506532_0	646529.Desaci_1639	5.766e-31	124.0	arCOG09714@1|root,33H0I@2|Bacteria,1UDFF@1239|Firmicutes,24N03@186801|Clostridia,26691@186807|Peptococcaceae	186801|Clostridia	S	TIGRFAM TIGR04076 family protein	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_5506532_1	903814.ELI_3778	1.38e-26	119.0	COG0042@1|root,COG0042@2|Bacteria,1TQ2R@1239|Firmicutes,248HD@186801|Clostridia,25VHB@186806|Eubacteriaceae	186801|Clostridia	H	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	dus	-	-	ko:K05540	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
PYH1_k127_5518534_2	1120956.JHZK01000007_gene2836	0.0009594	44.0	COG0477@1|root,COG0477@2|Bacteria,1QTUM@1224|Proteobacteria,2TVX9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EGP	COG0477 Permeases of the major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like
PYH1_k127_5518534_0	1069080.KB913028_gene130	2.686e-64	230.0	COG3872@1|root,COG3872@2|Bacteria,1TPBU@1239|Firmicutes,4H271@909932|Negativicutes	909932|Negativicutes	S	Psort location CytoplasmicMembrane, score 10.00	-	-	-	-	-	-	-	-	-	-	-	-	DUF1385
PYH1_k127_5518534_1	1365176.N186_01865	6.897e-06	51.0	COG5431@1|root,arCOG01121@2157|Archaea	2157|Archaea	S	zinc finger, SWIM	-	-	-	-	-	-	-	-	-	-	-	-	SWIM
PYH1_k127_5540696_0	1131266.ARWQ01000001_gene1364	1.325e-137	447.0	COG0112@1|root,arCOG00070@2157|Archaea,41S7U@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
PYH1_k127_5540696_1	579137.Metvu_0544	1.67e-66	233.0	COG0126@1|root,arCOG00496@2157|Archaea,2XSXX@28890|Euryarchaeota,23QGF@183939|Methanococci	183939|Methanococci	G	Belongs to the phosphoglycerate kinase family	pgk	-	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
PYH1_k127_555639_0	1131266.ARWQ01000001_gene1154	3.051e-137	454.0	COG0495@1|root,arCOG00809@2157|Archaea,41SES@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1
PYH1_k127_5586521_1	1122604.JONR01000033_gene8	6.38e-41	155.0	COG4319@1|root,COG4319@2|Bacteria,1N361@1224|Proteobacteria,1S9P8@1236|Gammaproteobacteria,1X7TS@135614|Xanthomonadales	135614|Xanthomonadales	S	Domain of unknown function (DUF4440)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440,SnoaL_2,SnoaL_3
PYH1_k127_5586521_0	742740.HMPREF9474_01472	3.459e-104	350.0	COG1735@1|root,COG1735@2|Bacteria,1TS8I@1239|Firmicutes,24K5B@186801|Clostridia,2244M@1506553|Lachnoclostridium	186801|Clostridia	C	Phosphotriesterase family	-	-	-	-	-	-	-	-	-	-	-	-	PTE
PYH1_k127_560288_3	497964.CfE428DRAFT_1241	1.076e-08	67.0	COG0318@1|root,COG0318@2|Bacteria	2|Bacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	-	-	-	-	-	-	-	-	-	-	GH3
PYH1_k127_560288_0	1220534.B655_1414	4.585e-50	187.0	arCOG04883@1|root,arCOG04883@2157|Archaea,2XZSU@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_560288_1	868131.MSWAN_2291	3.325e-32	136.0	COG0030@1|root,arCOG04131@2157|Archaea,2XU1Q@28890|Euryarchaeota,23NYN@183925|Methanobacteria	183925|Methanobacteria	J	Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
PYH1_k127_560288_2	273063.STK_03115	5.456e-14	74.0	COG1522@1|root,arCOG01117@2157|Archaea,2XR1K@28889|Crenarchaeota	28889|Crenarchaeota	K	PFAM regulatory protein AsnC Lrp family	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
PYH1_k127_560288_4	240302.BN982_01522	7.838e-05	54.0	COG3595@1|root,COG3595@2|Bacteria,1TS90@1239|Firmicutes,4HDI6@91061|Bacilli,3NE2J@45667|Halobacillus	91061|Bacilli	S	Putative adhesin	yvlB	-	-	-	-	-	-	-	-	-	-	-	DUF4097
PYH1_k127_5621098_0	1220534.B655_2454	6.51e-75	262.0	COG1899@1|root,arCOG04142@2157|Archaea,2XSTD@28890|Euryarchaeota,23NS4@183925|Methanobacteria	183925|Methanobacteria	O	Deoxyhypusine synthase	dys	-	2.5.1.46	ko:K00809	-	-	-	-	ko00000,ko01000	-	-	-	DS
PYH1_k127_5621098_1	415426.Hbut_1663	1.977e-38	147.0	COG0231@1|root,arCOG04277@2157|Archaea,2XQCW@28889|Crenarchaeota	28889|Crenarchaeota	J	Functions by promoting the formation of the first peptide bond	eif5a	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03263	-	-	-	-	ko00000,ko03012	-	-	-	EFP_N,eIF-5a
PYH1_k127_5621098_2	868131.MSWAN_1363	6.15e-16	80.0	COG0535@1|root,arCOG00938@2157|Archaea,2XZ9M@28890|Euryarchaeota	28890|Euryarchaeota	S	PFAM Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	DUF3463,Fer4_12,Radical_SAM,SPASM
PYH1_k127_5629947_0	368408.Tpen_1350	2.062e-151	488.0	COG1473@1|root,arCOG01108@2157|Archaea,2XRII@28889|Crenarchaeota	28889|Crenarchaeota	E	carboxypeptidase activity	-	-	-	ko:K12941,ko:K13048	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
PYH1_k127_5629947_2	397948.Cmaq_1339	6.506e-09	64.0	COG3601@1|root,arCOG03794@2157|Archaea,2XR5K@28889|Crenarchaeota	28889|Crenarchaeota	S	Membrane protein-like protein	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_5629947_1	272844.PAB0294.1n	1.207e-17	86.0	arCOG05754@1|root,arCOG05754@2157|Archaea,2Y475@28890|Euryarchaeota,244H9@183968|Thermococci	183968|Thermococci	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_5646334_0	1229909.NSED_01320	1.141e-73	265.0	COG1009@1|root,arCOG01539@2157|Archaea,41TBF@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Proton-conducting membrane transporter	-	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
PYH1_k127_5646334_1	1379698.RBG1_1C00001G0857	4.028e-16	84.0	COG5557@1|root,COG5557@2|Bacteria,2NNNQ@2323|unclassified Bacteria	1379698.RBG1_1C00001G0857|-	C	Polysulphide reductase, NrfD	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_5661822_0	891968.Anamo_1957	5.227e-48	186.0	COG3653@1|root,COG3653@2|Bacteria,3T9T6@508458|Synergistetes	508458|Synergistetes	Q	Amidohydrolase family	-	-	3.5.1.81	ko:K06015	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Amidohydro_3
PYH1_k127_5661822_1	1123371.ATXH01000045_gene1866	4.382e-35	142.0	COG1751@1|root,COG1751@2|Bacteria,2GIEF@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	Pyruvate kinase, alpha/beta domain	-	-	-	ko:K09126	-	-	-	-	ko00000	-	-	-	PK_C
PYH1_k127_5661822_2	688269.Theth_1294	6.507e-22	101.0	2BYY4@1|root,2Z80Y@2|Bacteria,2GCJB@200918|Thermotogae	200918|Thermotogae	S	Domain of unknown function (DUF4438)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4438
PYH1_k127_5709799_2	1273538.G159_15050	2.313e-39	154.0	COG0190@1|root,COG0190@2|Bacteria,1TP1P@1239|Firmicutes,4H9Q6@91061|Bacilli,26E1Z@186818|Planococcaceae	91061|Bacilli	E	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
PYH1_k127_5709799_0	1280706.AUJE01000017_gene172	4.538e-188	602.0	COG2759@1|root,COG2759@2|Bacteria,1TP6N@1239|Firmicutes,4H1XW@909932|Negativicutes	909932|Negativicutes	H	Belongs to the formate--tetrahydrofolate ligase family	fhs	-	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
PYH1_k127_5709799_1	565033.GACE_0596	7.398e-75	260.0	COG1927@1|root,arCOG04382@2157|Archaea,2XUX3@28890|Euryarchaeota,24626@183980|Archaeoglobi	183980|Archaeoglobi	C	Catalyzes the oxidation of methylene-H(4)MPT to methenyl-H(4)MPT( )	mtd	-	1.5.98.1	ko:K00319	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R04456	RC00202	ko00000,ko00001,ko00002,ko01000	-	-	-	MTD
PYH1_k127_5709799_3	679926.Mpet_0946	1.958e-34	137.0	COG1370@1|root,arCOG00991@2157|Archaea,2XYFT@28890|Euryarchaeota,2N9W0@224756|Methanomicrobia	224756|Methanomicrobia	O	PFAM PUA domain containing protein	-	-	-	ko:K07398	-	-	-	-	ko00000	-	-	-	PUA,TGT_C2
PYH1_k127_5709799_4	224325.AF_1977	1.348e-19	94.0	COG1813@1|root,arCOG01863@2157|Archaea,2XXND@28890|Euryarchaeota,24732@183980|Archaeoglobi	183980|Archaeoglobi	K	Transcriptional regulator, XRE family	-	-	-	ko:K03627	-	-	-	-	ko00000	-	-	-	HTH_3
PYH1_k127_5722912_0	635013.TherJR_2465	8.86e-67	239.0	COG0531@1|root,COG0531@2|Bacteria,1TQE1@1239|Firmicutes,249N1@186801|Clostridia,260S4@186807|Peptococcaceae	186801|Clostridia	E	amino acid	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
PYH1_k127_5745880_1	521011.Mpal_2220	9.128e-84	287.0	COG1131@1|root,arCOG00194@2157|Archaea,2XT0T@28890|Euryarchaeota,2NAAZ@224756|Methanomicrobia	224756|Methanomicrobia	V	TIGRFAM daunorubicin resistance ABC transporter ATPase subunit	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
PYH1_k127_5745880_6	374847.Kcr_0513	1.062e-10	64.0	COG2217@1|root,COG3350@1|root,arCOG01576@2157|Archaea,arCOG04507@2157|Archaea	2157|Archaea	P	PFAM YHS domain	copB	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hydrolase,YHS
PYH1_k127_5745880_0	927677.ALVU02000001_gene4597	6.442e-92	310.0	COG0384@1|root,COG0384@2|Bacteria,1G0Y0@1117|Cyanobacteria,1H5RJ@1142|Synechocystis	1117|Cyanobacteria	S	Phenazine biosynthesis-like protein	-	-	5.3.3.17	ko:K06998	ko00405,ko01130,ko02024,map00405,map01130,map02024	M00835	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	PhzC-PhzF
PYH1_k127_5745880_7	1197130.BAFM01000009_gene1682	0.0002177	51.0	COG1661@1|root,arCOG04212@2157|Archaea,2XX9D@28890|Euryarchaeota,23VIU@183963|Halobacteria	183963|Halobacteria	S	DNA-binding protein with PD1-like DNA-binding motif	-	-	-	ko:K06934	-	-	-	-	ko00000	-	-	-	DUF296
PYH1_k127_5745880_5	1459636.NTE_00055	9.82e-24	104.0	COG1733@1|root,arCOG01057@2157|Archaea	2157|Archaea	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
PYH1_k127_5745880_2	1041930.Mtc_2327	3.063e-67	238.0	arCOG01792@1|root,arCOG01792@2157|Archaea,2XSXC@28890|Euryarchaeota,2N9K5@224756|Methanomicrobia	224756|Methanomicrobia	Q	Ribosomal protein L11 methyltransferase (PrmA)	-	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_31
PYH1_k127_5745880_4	195522.BD01_1211	9.139e-28	119.0	arCOG06115@1|root,arCOG06115@2157|Archaea,2Y2V7@28890|Euryarchaeota,243EA@183968|Thermococci	183968|Thermococci	S	Bacterial PH domain	-	-	-	-	-	-	-	-	-	-	-	-	SHOCT,bPH_3
PYH1_k127_5745880_3	469617.FUAG_00734	1.813e-52	194.0	COG2217@1|root,COG2217@2|Bacteria,378XG@32066|Fusobacteria	32066|Fusobacteria	P	Psort location CytoplasmicMembrane, score	-	-	-	ko:K12950	-	-	-	-	ko00000,ko01000	3.A.3.32	-	-	E1-E2_ATPase,Hydrolase
PYH1_k127_5766600_0	1094980.Mpsy_0796	2.506e-117	388.0	COG1964@1|root,arCOG00933@2157|Archaea,2XTMK@28890|Euryarchaeota,2N91G@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM Radical SAM domain protein	-	-	-	ko:K06937	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Fer4_14,Radical_SAM
PYH1_k127_5766600_1	102125.Xen7305DRAFT_00020850	1.164e-71	250.0	COG3823@1|root,COG3823@2|Bacteria,1GPV5@1117|Cyanobacteria,3VMFK@52604|Pleurocapsales	1117|Cyanobacteria	O	Glutamine cyclotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Glu_cyclase_2
PYH1_k127_5766600_2	1189612.A33Q_1920	1.487e-70	254.0	COG0624@1|root,COG0624@2|Bacteria	2|Bacteria	E	succinyl-diaminopimelate desuccinylase activity	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
PYH1_k127_5768101_2	589924.Ferp_1122	2.233e-40	154.0	COG1104@1|root,arCOG00066@2157|Archaea,2Y7J8@28890|Euryarchaeota,245VC@183980|Archaeoglobi	183980|Archaeoglobi	E	Cysteine desulfurase	-	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
PYH1_k127_5768101_1	373994.Riv7116_2025	1.968e-41	158.0	COG1670@1|root,COG1670@2|Bacteria,1G5GV@1117|Cyanobacteria,1HQBR@1161|Nostocales	1117|Cyanobacteria	J	Acetyltransferase (GNAT) domain	-	-	2.3.1.128	ko:K03790	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_3
PYH1_k127_5768101_0	999630.TUZN_2123	2.016e-109	363.0	COG1201@1|root,arCOG00557@2157|Archaea,2XPNI@28889|Crenarchaeota	28889|Crenarchaeota	L	DEAD DEAH box helicase domain protein	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
PYH1_k127_5775075_1	1121904.ARBP01000003_gene6365	5.594e-64	227.0	COG0498@1|root,COG0498@2|Bacteria,4NKWI@976|Bacteroidetes,47SIW@768503|Cytophagia	976|Bacteroidetes	E	Pyridoxal-phosphate dependent enzyme	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	LeuA_dimer,PALP
PYH1_k127_5775075_0	368408.Tpen_1413	2.032e-214	682.0	COG2414@1|root,arCOG00709@2157|Archaea,2XRUI@28889|Crenarchaeota	28889|Crenarchaeota	C	Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
PYH1_k127_5775075_2	368408.Tpen_1412	7.158e-56	200.0	COG1142@1|root,arCOG01502@2157|Archaea,2XR9N@28889|Crenarchaeota	28889|Crenarchaeota	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_3,Fer4_4,Fer4_6,Fer4_9
PYH1_k127_5775075_3	410359.Pcal_1693	2.093e-18	86.0	COG1201@1|root,arCOG00557@2157|Archaea,2XPNI@28889|Crenarchaeota	28889|Crenarchaeota	L	DEAD DEAH box helicase domain protein	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
PYH1_k127_5782573_0	935948.KE386494_gene217	4.587e-153	495.0	COG3383@1|root,COG4624@1|root,COG3383@2|Bacteria,COG4624@2|Bacteria,1TP6C@1239|Firmicutes,24897@186801|Clostridia,42FJV@68295|Thermoanaerobacterales	186801|Clostridia	C	NADH ubiquinone oxidoreductase, subunit G, iron-sulphur binding	-	-	1.12.1.3,1.6.5.3	ko:K00336,ko:K18332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,Fer4_7,Fer4_9,NADH-G_4Fe-4S_3
PYH1_k127_5782573_1	572547.Amico_1556	3.856e-116	380.0	COG1894@1|root,COG1894@2|Bacteria,3TAJW@508458|Synergistetes	508458|Synergistetes	C	PFAM Respiratory-chain NADH dehydrogenase domain 51 kDa subunit	-	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
PYH1_k127_5810127_0	1229909.NSED_00235	9.89e-72	252.0	COG0037@1|root,arCOG00042@2157|Archaea,41S84@651137|Thaumarchaeota	651137|Thaumarchaeota	D	PP-loop family	-	-	-	-	-	-	-	-	-	-	-	-	ATP_bind_3
PYH1_k127_5810127_2	985053.VMUT_0877	0.0002586	47.0	COG1977@1|root,arCOG00537@2157|Archaea	2157|Archaea	H	ThiS family	-	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
PYH1_k127_5810127_1	1459636.NTE_02686	5.207e-10	63.0	arCOG08817@1|root,arCOG08817@2157|Archaea,41SV5@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_5834883_0	1223545.GS4_11_01520	4.494e-33	139.0	COG0714@1|root,COG0714@2|Bacteria,2GMBP@201174|Actinobacteria,4GCX8@85026|Gordoniaceae	201174|Actinobacteria	S	ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA_5,VWA_CoxE
PYH1_k127_5836416_2	604354.TSIB_2013	0.0002229	48.0	COG1373@1|root,arCOG03167@2157|Archaea,2XWQU@28890|Euryarchaeota,245DP@183968|Thermococci	183968|Thermococci	S	Domain of unknown function (DUF4143)	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
PYH1_k127_5836416_0	1828.JOKB01000019_gene1465	4.167e-63	227.0	COG0726@1|root,COG0726@2|Bacteria,2GM0X@201174|Actinobacteria,4FZPC@85025|Nocardiaceae	201174|Actinobacteria	G	Polysaccharide deacetylase	-	-	3.5.1.104	ko:K22278	-	-	-	-	ko00000,ko01000	-	-	-	Polysacc_deac_1
PYH1_k127_5836416_1	586413.CCDL010000001_gene68	1.766e-10	65.0	COG0500@1|root,COG2226@2|Bacteria,1U9IT@1239|Firmicutes,4HDV5@91061|Bacilli,23MCJ@182709|Oceanobacillus	91061|Bacilli	Q	Methionine biosynthesis protein MetW	rebM	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
PYH1_k127_5849239_1	552811.Dehly_1029	7.288e-30	122.0	COG1592@1|root,COG4802@1|root,COG1592@2|Bacteria,COG4802@2|Bacteria,2GATJ@200795|Chloroflexi,34DB7@301297|Dehalococcoidia	301297|Dehalococcoidia	C	Ferredoxin thioredoxin reductase catalytic beta chain	-	-	-	-	-	-	-	-	-	-	-	-	FeThRed_B
PYH1_k127_5849239_2	868131.MSWAN_0171	7.153e-21	94.0	COG0695@1|root,arCOG02606@2157|Archaea,2Y0MA@28890|Euryarchaeota	28890|Euryarchaeota	O	PFAM glutaredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Glutaredoxin
PYH1_k127_5849239_0	985053.VMUT_0553	6.487e-89	301.0	COG0006@1|root,arCOG01000@2157|Archaea	2157|Archaea	E	Belongs to the peptidase M24B family	-	-	-	-	-	-	-	-	-	-	-	-	Creatinase_N,Peptidase_M24
PYH1_k127_5850469_1	224325.AF_1238	2.296e-137	455.0	COG1148@1|root,COG1908@1|root,arCOG02235@2157|Archaea,arCOG02476@2157|Archaea,2XT3X@28890|Euryarchaeota,245U1@183980|Archaeoglobi	183980|Archaeoglobi	C	Heterodisulfide reductase subunit A and related polyferredoxins	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,FlpD,Pyr_redox_2
PYH1_k127_5850469_0	693661.Arcve_1116	1.253e-142	481.0	COG1148@1|root,COG1908@1|root,arCOG02235@2157|Archaea,arCOG02475@2157|Archaea,2XT3X@28890|Euryarchaeota,245U1@183980|Archaeoglobi	28890|Euryarchaeota	C	Heterodisulfide reductase subunit A and related polyferredoxins	hdrA-2	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388,ko:K16886	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_17,Fer4_4,Fer4_7,Fer4_9,FlpD,Pyr_redox_2
PYH1_k127_5850469_2	304371.MCP_2774	1.054e-92	321.0	COG0374@1|root,arCOG01549@2157|Archaea,2XTHE@28890|Euryarchaeota	28890|Euryarchaeota	C	PFAM Nickel-dependent hydrogenase, large subunit	mvhA-2	-	1.12.1.2,1.12.1.3,1.12.1.5,1.8.98.5	ko:K00436,ko:K14126,ko:K17993	ko00680,ko00920,map00680,map00920	-	R00019,R00700,R10390,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
PYH1_k127_5850469_3	243232.MJ_1191	6.431e-52	191.0	COG1941@1|root,arCOG02472@2157|Archaea,2XVJ0@28890|Euryarchaeota,23QEJ@183939|Methanococci	183939|Methanococci	C	PFAM NADH ubiquinone oxidoreductase 20 kDa subunit	vhuG	-	1.8.98.5	ko:K14128	ko00680,map00680	-	R00019,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	Oxidored_q6
PYH1_k127_5876987_1	1535287.JP74_11855	4.372e-34	141.0	COG0454@1|root,COG0456@2|Bacteria,1NGUX@1224|Proteobacteria,2UWRR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
PYH1_k127_5876987_0	1173024.KI912154_gene1186	9.883e-56	203.0	COG0596@1|root,COG0596@2|Bacteria,1GFX0@1117|Cyanobacteria,1JKES@1189|Stigonemataceae	1117|Cyanobacteria	S	Thioesterase domain	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
PYH1_k127_5879052_2	1131266.ARWQ01000001_gene1088	5.685e-32	135.0	COG0367@1|root,arCOG00071@2157|Archaea,41SIX@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Asparagine synthase	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase
PYH1_k127_5879052_0	1123288.SOV_1c02250	5.906e-64	226.0	COG0500@1|root,COG0500@2|Bacteria,1V0PR@1239|Firmicutes,4H9CG@909932|Negativicutes	909932|Negativicutes	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
PYH1_k127_5879052_1	457570.Nther_0036	9.88e-45	171.0	COG0428@1|root,COG0428@2|Bacteria,1TP7J@1239|Firmicutes,247Q2@186801|Clostridia	186801|Clostridia	P	transporter	-	-	-	ko:K07238	-	-	-	-	ko00000,ko02000	2.A.5.5	-	-	Zip
PYH1_k127_5881506_0	1121935.AQXX01000129_gene1798	1.081e-50	183.0	COG0328@1|root,COG0328@2|Bacteria,1RCZ1@1224|Proteobacteria,1S3YC@1236|Gammaproteobacteria,1XJJ8@135619|Oceanospirillales	135619|Oceanospirillales	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhA	-	3.1.26.4	ko:K03469	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_H
PYH1_k127_5881506_1	318829.MGG_10158T0	5.251e-16	88.0	28M7N@1|root,2QTQR@2759|Eukaryota,39YDM@33154|Opisthokonta,3NXMH@4751|Fungi,3QNF1@4890|Ascomycota,21S10@147550|Sordariomycetes,41J11@639021|Magnaporthales	4751|Fungi	S	QDE-2-interacting protein	-	GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005739,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_5897647_1	523850.TON_0016	6.286e-47	181.0	COG3839@1|root,arCOG00175@2157|Archaea,2Y7NF@28890|Euryarchaeota,242VD@183968|Thermococci	183968|Thermococci	G	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.55	ko:K06857	ko02010,map02010	M00186	R10531	RC00002	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	ABC_tran
PYH1_k127_5897647_2	436308.Nmar_1452	4.374e-13	74.0	arCOG05529@1|root,arCOG05529@2157|Archaea,41SSJ@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	dsDNA_bind
PYH1_k127_5897647_0	1220534.B655_1154	1.171e-142	467.0	COG2217@1|root,arCOG01576@2157|Archaea,2XTD8@28890|Euryarchaeota,23NU1@183925|Methanobacteria	183925|Methanobacteria	P	heavy metal-(Cd Co Hg Pb Zn)-translocating	-	-	3.6.3.3,3.6.3.5	ko:K01534	-	-	-	-	ko00000,ko01000	3.A.3.6	-	-	E1-E2_ATPase,Hydrolase
PYH1_k127_5949205_0	159749.E7BWH9	1.072e-102	340.0	COG3854@1|root,2QQ4X@2759|Eukaryota,2XEFS@2836|Bacillariophyta	2836|Bacillariophyta	L	AAA domain	ycf45	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_5949205_1	1095747.HMPREF1049_1311	2.879e-22	98.0	COG0236@1|root,COG0236@2|Bacteria,37AM1@32066|Fusobacteria	32066|Fusobacteria	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
PYH1_k127_5953596_1	420247.Msm_1584	3.218e-27	114.0	COG1833@1|root,arCOG00463@2157|Archaea,2Y00K@28890|Euryarchaeota,23PNF@183925|Methanobacteria	183925|Methanobacteria	L	excinuclease ABC, C subunit	-	-	-	-	-	-	-	-	-	-	-	-	DUF123
PYH1_k127_5953596_0	387631.Asulf_00555	4.735e-54	197.0	arCOG05906@1|root,arCOG05906@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_5957030_0	1499967.BAYZ01000028_gene1366	1.948e-140	460.0	COG3653@1|root,COG3653@2|Bacteria,2NNQ0@2323|unclassified Bacteria	2|Bacteria	Q	Amidohydrolase family	dan	-	3.5.1.81	ko:K06015	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Amidohydro_3
PYH1_k127_5981147_1	298655.KI912266_gene1703	8.64e-10	64.0	COG0317@1|root,COG0317@2|Bacteria,2IP1T@201174|Actinobacteria	201174|Actinobacteria	KT	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	HD_4
PYH1_k127_5981147_0	132113.XP_003494297.1	1.074e-26	114.0	COG0526@1|root,KOG0910@2759|Eukaryota,3A8MT@33154|Opisthokonta	33154|Opisthokonta	O	glycerol ether metabolic process	-	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
PYH1_k127_6010953_0	1121430.JMLG01000009_gene440	1.216e-61	218.0	COG3808@1|root,COG3808@2|Bacteria,1TNZI@1239|Firmicutes,248KS@186801|Clostridia,260WE@186807|Peptococcaceae	186801|Clostridia	C	Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na( ) movement across the membrane	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
PYH1_k127_6010953_1	1131266.ARWQ01000001_gene1081	1.566e-43	169.0	COG0611@1|root,arCOG00638@2157|Archaea,41SIN@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
PYH1_k127_6039884_1	604354.TSIB_0634	1.466e-57	207.0	COG2423@1|root,arCOG01035@2157|Archaea,2XTTC@28890|Euryarchaeota	28890|Euryarchaeota	E	Catalyzes the NAD( )-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate	ala	GO:0000166,GO:0000286,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006522,GO:0006807,GO:0008150,GO:0008152,GO:0009078,GO:0009987,GO:0016491,GO:0016638,GO:0019752,GO:0036094,GO:0042802,GO:0042803,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046983,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901564,GO:1901605	1.4.1.1	ko:K19244	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	OCD_Mu_crystall
PYH1_k127_6039884_2	240015.ACP_2902	2.414e-36	142.0	COG1051@1|root,COG1051@2|Bacteria,3Y5BM@57723|Acidobacteria,2JJTC@204432|Acidobacteriia	204432|Acidobacteriia	F	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
PYH1_k127_6039884_0	644281.MFS40622_1214	1.815e-196	633.0	COG0145@1|root,arCOG01511@2157|Archaea,2XT1J@28890|Euryarchaeota	28890|Euryarchaeota	E	COG0145 N-methylhydantoinase A acetone carboxylase beta subunit	-	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006518,GO:0006575,GO:0006749,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0017168,GO:0034641,GO:0043603,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0071704,GO:1901564	3.5.2.14,3.5.2.9	ko:K01469,ko:K01473	ko00330,ko00480,ko01100,map00330,map00480,map01100	-	R00251,R03187	RC00553,RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A,Hydantoinase_B
PYH1_k127_6039884_3	224324.aq_1925	1.443e-27	115.0	COG0146@1|root,COG0146@2|Bacteria,2G3NG@200783|Aquificae	200783|Aquificae	EQ	Hydantoinase B/oxoprolinase	-	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
PYH1_k127_606132_0	1234364.AMSF01000010_gene480	2.177e-05	57.0	COG3409@1|root,COG3409@2|Bacteria,1RF7I@1224|Proteobacteria,1S3UR@1236|Gammaproteobacteria,1X7DS@135614|Xanthomonadales	135614|Xanthomonadales	M	Putative peptidoglycan binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1
PYH1_k127_6062519_0	1244869.H261_03308	6.451e-46	172.0	COG0827@1|root,COG0827@2|Bacteria,1QUSC@1224|Proteobacteria,2TW5J@28211|Alphaproteobacteria,2JZ6A@204441|Rhodospirillales	204441|Rhodospirillales	L	DNA restriction-modification system	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_6062968_1	1229909.NSED_03215	1.348e-71	252.0	COG1405@1|root,arCOG01981@2157|Archaea,41SXZ@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	-	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
PYH1_k127_6062968_3	1157490.EL26_00870	3.812e-06	51.0	COG1141@1|root,COG1141@2|Bacteria,1USZ5@1239|Firmicutes,4I648@91061|Bacilli,278NT@186823|Alicyclobacillaceae	91061|Bacilli	C	4Fe-4S single cluster domain of Ferredoxin I	-	-	-	ko:K05337	-	-	-	-	ko00000	-	-	-	Fer4_13
PYH1_k127_6062968_0	342949.PNA2_1572	6.763e-93	323.0	COG0520@1|root,arCOG00065@2157|Archaea,2XVQU@28890|Euryarchaeota,243RH@183968|Thermococci	2157|Archaea	E	Cys/Met metabolism PLP-dependent enzyme	-	-	3.7.1.3,4.1.2.48	ko:K01556,ko:K01620	ko00260,ko00380,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00380,map01100,map01110,map01120,map01130,map01230	M00038	R00751,R00987,R02668,R03936,R06171	RC00284,RC00312,RC00372,RC00415	ko00000,ko00001,ko00002,ko01000	-	-	-	Aminotran_5,Beta_elim_lyase
PYH1_k127_6062968_2	1382306.JNIM01000001_gene910	3.106e-41	154.0	COG1171@1|root,COG1171@2|Bacteria,2G5YN@200795|Chloroflexi	200795|Chloroflexi	E	Pyridoxal-phosphate dependent enzyme	-	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
PYH1_k127_608414_2	511051.CSE_10810	7.451e-18	85.0	COG2379@1|root,COG2379@2|Bacteria	2|Bacteria	G	hydroxypyruvate reductase	ttuD	-	2.7.1.165	ko:K11529	ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200	M00346	R08572	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4147,MOFRL
PYH1_k127_608414_3	868131.MSWAN_0328	1.224e-08	61.0	COG1658@1|root,arCOG01486@2157|Archaea,2Y0G2@28890|Euryarchaeota	28890|Euryarchaeota	L	Belongs to the UPF0292 family	-	-	-	-	-	-	-	-	-	-	-	-	Toprim,Toprim_4
PYH1_k127_608414_0	562970.Btus_3035	1.377e-33	138.0	COG0235@1|root,COG0235@2|Bacteria,1TPDV@1239|Firmicutes,4HDTK@91061|Bacilli,279XZ@186823|Alicyclobacillaceae	91061|Bacilli	G	Class II Aldolase and Adducin N-terminal domain	araD	-	4.1.2.17,5.1.3.4	ko:K01628,ko:K03077	ko00040,ko00051,ko00053,ko01100,ko01120,map00040,map00051,map00053,map01100,map01120	M00550	R02262,R05850	RC00603,RC00604,RC01479	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase_II
PYH1_k127_608414_1	267377.MMP0817	2.752e-20	92.0	COG1035@1|root,arCOG02651@2157|Archaea,2XUH6@28890|Euryarchaeota,23RDD@183939|Methanococci	183939|Methanococci	C	PFAM coenzyme F420 hydrogenase dehydrogenase beta subunit domain protein	-	-	1.12.98.1	ko:K00441	ko00680,ko01100,ko01120,map00680,map01100,map01120	-	R03025	RC02628	ko00000,ko00001,ko01000	-	-	-	FrhB_FdhB_C,FrhB_FdhB_N
PYH1_k127_6102502_3	349161.Dred_1788	3.218e-70	244.0	COG0413@1|root,COG0413@2|Bacteria,1TPZA@1239|Firmicutes,248RR@186801|Clostridia,260CY@186807|Peptococcaceae	186801|Clostridia	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
PYH1_k127_6102502_4	1183377.Py04_1355	5.043e-49	187.0	COG1893@1|root,arCOG04139@2157|Archaea,2XTBD@28890|Euryarchaeota,243P9@183968|Thermococci	183968|Thermococci	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
PYH1_k127_6102502_2	768672.Desfe_0418	1.287e-88	299.0	COG1701@1|root,arCOG04262@2157|Archaea,2XPPD@28889|Crenarchaeota	28889|Crenarchaeota	S	Pantothenate synthetase	-	-	6.3.2.36	ko:K09722	ko00410,ko00770,ko01100,map00410,map00770,map01100	-	R09379	RC00096,RC00141	ko00000,ko00001,ko01000	-	-	-	PPS_PS
PYH1_k127_6102502_0	1459636.NTE_02178	1.028e-187	601.0	COG0028@1|root,arCOG01998@2157|Archaea,41S63@651137|Thaumarchaeota	651137|Thaumarchaeota	E	TIGRFAM acetolactate synthase, large subunit, biosynthetic type	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
PYH1_k127_6102502_5	1459636.NTE_02177	3.694e-39	152.0	COG0440@1|root,arCOG04445@2157|Archaea,41SNS@651137|Thaumarchaeota	651137|Thaumarchaeota	E	acetolactate synthase, small	-	-	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,ACT_5,ALS_ss_C
PYH1_k127_6102502_1	1183377.Py04_0848	2.129e-114	375.0	COG0059@1|root,arCOG04465@2157|Archaea,2XTGU@28890|Euryarchaeota,242YF@183968|Thermococci	183968|Thermococci	E	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
PYH1_k127_6120634_1	945713.IALB_1980	2.76e-40	150.0	COG0205@1|root,COG0205@2|Bacteria	2|Bacteria	G	6-phosphofructokinase activity	pfkA	-	2.7.1.11,2.7.1.90	ko:K00850,ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R00764,R02073,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	iJN678.pfkA	PFK
PYH1_k127_6120634_0	945713.IALB_1175	1.299e-149	482.0	2DBCF@1|root,2Z8DB@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Caps_assemb_Wzi
PYH1_k127_6149983_2	1459636.NTE_01468	8.338e-06	49.0	COG4023@1|root,arCOG02957@2157|Archaea,41SUS@651137|Thaumarchaeota	651137|Thaumarchaeota	U	Sec61beta family	-	-	-	-	-	-	-	-	-	-	-	-	Sec61_beta
PYH1_k127_6149983_3	273063.STK_12895	0.0004845	45.0	COG1581@1|root,arCOG01753@2157|Archaea,2XQTM@28889|Crenarchaeota	28889|Crenarchaeota	K	Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes	albA	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K03622	-	-	-	-	ko00000	-	-	-	Alba
PYH1_k127_6149983_1	647113.Metok_0593	1.381e-08	57.0	COG1581@1|root,arCOG01753@2157|Archaea,2XZH4@28890|Euryarchaeota,23R6Q@183939|Methanococci	183939|Methanococci	K	Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes	albA	-	-	ko:K03622	-	-	-	-	ko00000	-	-	-	Alba
PYH1_k127_6149983_0	1041930.Mtc_0570	5.643e-32	138.0	COG1599@1|root,arCOG01510@2157|Archaea,2XTJP@28890|Euryarchaeota,2N93V@224756|Methanomicrobia	224756|Methanomicrobia	L	PFAM nucleic acid binding, OB-fold, tRNA helicase-type	-	-	-	ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko03000,ko03032,ko03400	-	-	-	tRNA_anti-codon
PYH1_k127_6174638_1	1047013.AQSP01000126_gene2740	1.398e-22	100.0	COG2866@1|root,COG2866@2|Bacteria,2NQNH@2323|unclassified Bacteria	2|Bacteria	E	Zinc carboxypeptidase	-	-	-	ko:K14054	-	-	-	-	ko00000	-	-	-	AstE_AspA,Peptidase_M14
PYH1_k127_6174638_2	646529.Desaci_1639	4.316e-19	90.0	arCOG09714@1|root,33H0I@2|Bacteria,1UDFF@1239|Firmicutes,24N03@186801|Clostridia,26691@186807|Peptococcaceae	186801|Clostridia	S	TIGRFAM TIGR04076 family protein	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_6174638_3	1157490.EL26_11975	1.759e-18	93.0	COG2234@1|root,COG2234@2|Bacteria	2|Bacteria	DZ	aminopeptidase activity	-	-	-	ko:K07004	-	-	-	-	ko00000	-	-	-	PKD,PPC,Peptidase_M10,Peptidase_M28,SLH
PYH1_k127_6174638_0	1340493.JNIF01000004_gene1025	2.103e-43	176.0	COG2234@1|root,COG2234@2|Bacteria	2|Bacteria	DZ	aminopeptidase activity	-	-	-	ko:K07004	-	-	-	-	ko00000	-	-	-	PKD,PPC,Peptidase_M10,Peptidase_M28,SLH
PYH1_k127_6174638_5	357809.Cphy_0184	2.729e-05	53.0	28Q1F@1|root,2ZCJT@2|Bacteria,1VI7R@1239|Firmicutes,24D4W@186801|Clostridia,2216K@1506553|Lachnoclostridium	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_6174638_4	690585.JNNU01000015_gene230	1.088e-12	72.0	COG1168@1|root,COG1168@2|Bacteria,1MY33@1224|Proteobacteria,2TR29@28211|Alphaproteobacteria,4BDF2@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Aminotransferase class I and II	-	-	4.4.1.8	ko:K14155	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	-	R00782,R01286,R02408,R04941	RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
PYH1_k127_6200620_0	186497.PF1203	9.928e-230	724.0	COG2414@1|root,arCOG00707@2157|Archaea,2Y3BC@28890|Euryarchaeota,243IP@183968|Thermococci	183968|Thermococci	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
PYH1_k127_6205843_1	521011.Mpal_1206	5.361e-32	130.0	COG0301@1|root,arCOG00038@2157|Archaea,2XUHM@28890|Euryarchaeota,2N98H@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	thiI	-	2.8.1.4	ko:K03151	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07461	-	ko00000,ko00001,ko01000,ko03016	-	-	-	THUMP,ThiI
PYH1_k127_6205843_2	387631.Asulf_00380	5.178e-08	57.0	arCOG05390@1|root,arCOG05390@2157|Archaea,2Y414@28890|Euryarchaeota,2476A@183980|Archaeoglobi	183980|Archaeoglobi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_6205843_0	1125863.JAFN01000001_gene1726	2.117e-54	198.0	COG1351@1|root,COG1351@2|Bacteria,1R6TS@1224|Proteobacteria,43BGP@68525|delta/epsilon subdivisions	1224|Proteobacteria	H	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant	thyX	-	2.1.1.148	ko:K03465	ko00240,ko00670,ko01100,map00240,map00670,map01100	-	R06613	RC00022,RC00332	ko00000,ko00001,ko01000	-	-	-	Thy1
PYH1_k127_6222252_2	1239962.C943_03700	6.792e-22	97.0	COG3191@1|root,COG3191@2|Bacteria,4NGDT@976|Bacteroidetes,47K9S@768503|Cytophagia	976|Bacteroidetes	EQ	Peptidase family S58	-	-	3.4.11.19	ko:K01266	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S58
PYH1_k127_6222252_0	1118054.CAGW01000007_gene3802	2.644e-74	262.0	COG3535@1|root,COG3535@2|Bacteria,1TR39@1239|Firmicutes,4HBM2@91061|Bacilli,26RA6@186822|Paenibacillaceae	91061|Bacilli	S	Protein of unknown function (DUF917)	-	-	-	ko:K09703	-	-	-	-	ko00000	-	-	-	DUF917
PYH1_k127_6222252_1	56780.SYN_02434	6.882e-38	153.0	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	-	-	3.5.1.106	ko:K15357	ko00760,ko01120,map00760,map01120	M00622	R09126	RC00323,RC02431	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1,Abhydrolase_3,Abhydrolase_6,Hydrolase_4
PYH1_k127_6241014_2	388467.A19Y_2215	1.389e-56	205.0	COG0120@1|root,COG0120@2|Bacteria,1G2DW@1117|Cyanobacteria,1H811@1150|Oscillatoriales	1117|Cyanobacteria	G	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate	rpiA	GO:0003674,GO:0003824,GO:0004751,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006014,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009117,GO:0009987,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564	5.3.1.6	ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167,M00580	R01056	RC00434	ko00000,ko00001,ko00002,ko01000	-	-	iJN678.rpiA	Rib_5-P_isom_A
PYH1_k127_6241014_3	1220534.B655_1288	8.459e-10	68.0	COG0671@1|root,arCOG03056@2157|Archaea	2157|Archaea	I	PFAM phosphoesterase, PA-phosphatase related	sepP	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
PYH1_k127_6241014_0	368408.Tpen_0002	1.313e-134	438.0	COG1363@1|root,arCOG01518@2157|Archaea,2XPWC@28889|Crenarchaeota	28889|Crenarchaeota	G	peptidase M42 family protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M42
PYH1_k127_6241014_1	671065.MetMK1DRAFT_00023530	8.913e-58	210.0	COG2519@1|root,arCOG00978@2157|Archaea,2XPU6@28889|Crenarchaeota	28889|Crenarchaeota	J	PFAM tRNA methyltransferase complex GCD14 subunit	-	-	2.1.1.219,2.1.1.220	ko:K07442	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	GCD14,GCD14_N
PYH1_k127_6245964_1	1211844.CBLM010000110_gene3484	2.712e-14	81.0	COG2755@1|root,COG2755@2|Bacteria,1UVQE@1239|Firmicutes,3VT47@526524|Erysipelotrichia	526524|Erysipelotrichia	E	GDSL-like Lipase/Acylhydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
PYH1_k127_6245964_0	485913.Krac_1642	7.918e-42	166.0	COG2141@1|root,COG2141@2|Bacteria,2G873@200795|Chloroflexi	2|Bacteria	C	COGs COG2141 Coenzyme F420-dependent N5 N10-methylene tetrahydromethanopterin reductase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
PYH1_k127_6245964_2	28532.XP_010541679.1	0.0002798	43.0	COG0468@1|root,KOG1433@2759|Eukaryota,37M1K@33090|Viridiplantae,3GCRZ@35493|Streptophyta,3HMEG@3699|Brassicales	35493|Streptophyta	L	Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Unwinds duplex DNA. Component of the meiotic recombination pathway. Seems to play a role in mediating chromosome homology search, chromosome pairing and synapsis at early stages and probably chromosome crossing-over at later stages in meiosis. Probably is involved in the repair of meiotic double strand breaks (DBSs) and in homologous recombination	RAD51	GO:0000003,GO:0000150,GO:0000217,GO:0000228,GO:0000280,GO:0000400,GO:0000724,GO:0000725,GO:0000730,GO:0000793,GO:0000794,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005694,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006312,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007049,GO:0007127,GO:0007131,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009889,GO:0009987,GO:0010212,GO:0010332,GO:0010468,GO:0010556,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0022402,GO:0022414,GO:0022607,GO:0031323,GO:0031326,GO:0031974,GO:0031981,GO:0033554,GO:0034622,GO:0034641,GO:0035825,GO:0042148,GO:0042623,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044464,GO:0045003,GO:0046483,GO:0048285,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051276,GO:0051321,GO:0051716,GO:0060255,GO:0061982,GO:0065003,GO:0065004,GO:0065007,GO:0070013,GO:0070192,GO:0071704,GO:0071824,GO:0071840,GO:0080090,GO:0090304,GO:0090735,GO:0097159,GO:0140013,GO:0140097,GO:1901360,GO:1901363,GO:1903046,GO:1903506,GO:2000112,GO:2001141	-	ko:K04482	ko03440,ko03460,ko05200,ko05212,map03440,map03460,map05200,map05212	-	-	-	ko00000,ko00001,ko03400,ko04121,ko04131	-	-	-	HHH_5,Rad51
PYH1_k127_6252462_0	1379698.RBG1_1C00001G1620	7.487e-47	182.0	COG2222@1|root,COG2222@2|Bacteria,2NQVV@2323|unclassified Bacteria	2|Bacteria	M	Bacterial phospho-glucose isomerase C-terminal SIS domain	pgi	-	5.3.1.8,5.3.1.9	ko:K15916	ko00010,ko00030,ko00051,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R01819,R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	SIS,bact-PGI_C
PYH1_k127_6264274_2	70601.3257553	2.92e-27	115.0	COG2050@1|root,arCOG00777@2157|Archaea,2Y3RS@28890|Euryarchaeota,2447Q@183968|Thermococci	183968|Thermococci	Q	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
PYH1_k127_6264274_3	1131266.ARWQ01000002_gene489	2.196e-19	91.0	COG1758@1|root,arCOG01268@2157|Archaea,41ST9@651137|Thaumarchaeota	651137|Thaumarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoK	-	-	ko:K03014	ko00230,ko00240,ko01100,ko03020,ko04623,ko05016,ko05169,map00230,map00240,map01100,map03020,map04623,map05016,map05169	M00180,M00181,M00182	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
PYH1_k127_6264274_1	399741.Spro_3190	2.372e-117	385.0	COG0078@1|root,COG0078@2|Bacteria,1MUFM@1224|Proteobacteria,1RQ59@1236|Gammaproteobacteria,4007H@613|Serratia	1236|Gammaproteobacteria	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	-	2.1.3.3,2.1.3.9	ko:K00611,ko:K09065	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01398,R07245	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
PYH1_k127_6264274_0	272562.CA_C1427	1.377e-132	433.0	COG0160@1|root,COG0160@2|Bacteria,1VS6F@1239|Firmicutes,24YI0@186801|Clostridia,36ED9@31979|Clostridiaceae	186801|Clostridia	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	gabT	-	2.6.1.19,2.6.1.22	ko:K00823,ko:K07250	ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648,R04188	RC00006,RC00062,RC00160	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
PYH1_k127_6266328_4	1131730.BAVI_13159	6.306e-13	71.0	COG0251@1|root,COG0251@2|Bacteria,1V6G4@1239|Firmicutes,4HHIF@91061|Bacilli,1ZGKI@1386|Bacillus	91061|Bacilli	J	endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	YjgF_endoribonc
PYH1_k127_6266328_2	529709.PYCH_00770	1.525e-23	102.0	COG1581@1|root,arCOG01753@2157|Archaea,2XZH4@28890|Euryarchaeota,244BC@183968|Thermococci	183968|Thermococci	K	Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes	albA	-	-	ko:K03622	-	-	-	-	ko00000	-	-	-	Alba
PYH1_k127_6266328_3	1342301.JASD01000008_gene2628	6.496e-18	89.0	COG0346@1|root,COG0346@2|Bacteria,1RIW7@1224|Proteobacteria,2U9Y8@28211|Alphaproteobacteria,3ZXGA@60136|Sulfitobacter	28211|Alphaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
PYH1_k127_6266328_1	479434.Sthe_1797	3.229e-56	211.0	COG3616@1|root,COG3616@2|Bacteria,2G69D@200795|Chloroflexi,27XSK@189775|Thermomicrobia	200795|Chloroflexi	E	PFAM alanine racemase domain protein	-	-	4.3.1.27	ko:K20757	-	-	-	-	ko00000,ko01000	-	-	-	Ala_racemase_N,D-ser_dehydrat
PYH1_k127_6266328_0	192952.MM_1367	6.627e-58	206.0	COG1328@1|root,arCOG04889@2157|Archaea,2XT2S@28890|Euryarchaeota,2N92H@224756|Methanomicrobia	224756|Methanomicrobia	F	TIGRFAM anaerobic ribonucleoside-triphosphate reductase	nrdD	-	1.1.98.6	ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R11633,R11634,R11635,R11636	RC00613	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-cone,NRDD
PYH1_k127_6284175_0	309801.trd_1095	1.097e-87	298.0	COG2159@1|root,COG2159@2|Bacteria,2G8UX@200795|Chloroflexi,27Z57@189775|Thermomicrobia	189775|Thermomicrobia	S	Amidohydrolase	-	-	4.1.1.45	ko:K03392	ko00380,ko01100,map00380,map01100	M00038	R04323	RC00779	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_2
PYH1_k127_6284175_2	1033810.HLPCO_001722	1.839e-12	74.0	COG1670@1|root,COG1670@2|Bacteria,2NRYV@2323|unclassified Bacteria	2|Bacteria	J	Acetyltransferase (GNAT) domain	-	-	2.3.1.128	ko:K03790	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_3
PYH1_k127_6284175_1	1379698.RBG1_1C00001G0843	5.006e-14	80.0	COG1011@1|root,COG1011@2|Bacteria,2NQ1K@2323|unclassified Bacteria	2|Bacteria	S	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	3.1.3.5	ko:K07025,ko:K08723	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
PYH1_k127_6304034_1	926569.ANT_06740	2.334e-94	322.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	ko:K08217	-	-	-	-	br01600,ko00000,ko01504,ko02000	2.A.1.21.1,2.A.1.21.22	-	-	MFS_1
PYH1_k127_6304034_5	1144313.PMI10_03481	1.654e-11	75.0	COG3266@1|root,COG3866@1|root,COG3266@2|Bacteria,COG3866@2|Bacteria,4PN6U@976|Bacteroidetes,1IKRR@117743|Flavobacteriia,2P0VU@237|Flavobacterium	976|Bacteroidetes	G	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,CBM_6,DUF4990
PYH1_k127_6304034_0	1128421.JAGA01000003_gene3696	1.438e-224	711.0	COG1164@1|root,COG1164@2|Bacteria,2NNVV@2323|unclassified Bacteria	2|Bacteria	E	Oligopeptidase F	-	-	-	ko:K08602	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3,Peptidase_M3_N
PYH1_k127_6304034_4	1229909.NSED_07225	1.971e-19	93.0	COG0517@1|root,arCOG00606@2157|Archaea	2157|Archaea	I	CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
PYH1_k127_6304034_2	588581.Cpap_0338	1.665e-67	244.0	COG0787@1|root,COG0787@2|Bacteria,1TNYY@1239|Firmicutes,2480T@186801|Clostridia,3WGQU@541000|Ruminococcaceae	186801|Clostridia	M	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
PYH1_k127_6304034_3	304371.MCP_2281	1.96e-26	114.0	COG3467@1|root,arCOG00520@2157|Archaea	2157|Archaea	S	Pyridoxamine 5-phosphate	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Pyridox_ox_2
PYH1_k127_6308167_0	1047013.AQSP01000126_gene2740	7.402e-211	677.0	COG2866@1|root,COG2866@2|Bacteria,2NQNH@2323|unclassified Bacteria	2|Bacteria	E	Zinc carboxypeptidase	-	-	-	ko:K14054	-	-	-	-	ko00000	-	-	-	AstE_AspA,Peptidase_M14
PYH1_k127_6319657_0	1121918.ARWE01000001_gene2994	5.972e-132	429.0	COG1509@1|root,COG1509@2|Bacteria,1MUPJ@1224|Proteobacteria,42MNR@68525|delta/epsilon subdivisions,2WJ70@28221|Deltaproteobacteria,43U2W@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Lysine-2,3-aminomutase	-	-	5.4.3.2	ko:K01843	ko00310,map00310	-	R00461	RC00303	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,LAM_C,Radical_SAM
PYH1_k127_6319657_1	1232410.KI421421_gene3684	1.091e-96	327.0	COG1181@1|root,COG1181@2|Bacteria,1MX3I@1224|Proteobacteria,42SA1@68525|delta/epsilon subdivisions,2WNIR@28221|Deltaproteobacteria,43UHD@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	ATP-grasp domain	-	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
PYH1_k127_6319657_2	1232410.KI421421_gene3683	9.016e-77	269.0	COG1181@1|root,COG1181@2|Bacteria,1N4F5@1224|Proteobacteria,42NYM@68525|delta/epsilon subdivisions,2WKTX@28221|Deltaproteobacteria,43U6N@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	ATP-grasp domain	-	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
PYH1_k127_6320255_3	1321778.HMPREF1982_02348	2.607e-32	135.0	2DPWM@1|root,333PI@2|Bacteria,1UISI@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_6320255_2	647113.Metok_0092	1.446e-43	163.0	COG0041@1|root,arCOG02464@2157|Archaea,2XU0P@28890|Euryarchaeota,23QSX@183939|Methanococci	183939|Methanococci	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
PYH1_k127_6320255_1	1054217.TALC_00152	4.624e-71	248.0	COG0047@1|root,arCOG00102@2157|Archaea,2XTPA@28890|Euryarchaeota,241Q4@183967|Thermoplasmata	183967|Thermoplasmata	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purQ	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
PYH1_k127_6320255_0	247490.KSU1_D0830	1.408e-98	333.0	COG0046@1|root,COG0046@2|Bacteria,2IXRT@203682|Planctomycetes	203682|Planctomycetes	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C,PurS
PYH1_k127_633899_2	1122963.AUHB01000011_gene1403	1.48e-12	73.0	COG4747@1|root,COG4747@2|Bacteria,1RIFA@1224|Proteobacteria,2U98J@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	ACT domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_633899_0	521045.Kole_0146	6.41e-141	457.0	COG1168@1|root,COG1168@2|Bacteria,2GCM9@200918|Thermotogae	200918|Thermotogae	E	aminotransferase class I and II	-	-	4.4.1.8	ko:K14155	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	-	R00782,R01286,R02408,R04941	RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303	ko00000,ko00001,ko01000,ko01007	-	-	-	Acetyltransf_10,Aminotran_1_2
PYH1_k127_633899_1	351160.RCIX2175	5.128e-68	234.0	COG0178@1|root,arCOG04694@2157|Archaea,2XTDU@28890|Euryarchaeota,2N9EN@224756|Methanomicrobia	224756|Methanomicrobia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
PYH1_k127_6357555_0	1042877.GQS_01815	8.036e-11	68.0	arCOG01312@1|root,arCOG03256@1|root,arCOG03499@1|root,arCOG01312@2157|Archaea,arCOG03256@2157|Archaea,arCOG03499@2157|Archaea,2Y7MH@28890|Euryarchaeota,243S6@183968|Thermococci	183968|Thermococci	L	ABC-type uncharacterized transport system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux
PYH1_k127_6380433_1	224325.AF_1793	2.121e-16	80.0	COG1476@1|root,arCOG01864@2157|Archaea,2Y089@28890|Euryarchaeota	28890|Euryarchaeota	K	Transcriptional regulator	-	-	-	ko:K07729	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3
PYH1_k127_6380433_0	439481.Aboo_0717	4.368e-28	126.0	COG0477@1|root,arCOG00130@2157|Archaea,2Y719@28890|Euryarchaeota,3F34W@33867|unclassified Euryarchaeota	28890|Euryarchaeota	G	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
PYH1_k127_6401133_1	1343739.PAP_06020	1.876e-62	226.0	COG0312@1|root,arCOG00322@2157|Archaea,2XVT5@28890|Euryarchaeota,2435V@183968|Thermococci	183968|Thermococci	S	Putative modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
PYH1_k127_6401133_0	342949.PNA2_1872	2.516e-142	466.0	COG1530@1|root,arCOG00321@2157|Archaea,2XU9U@28890|Euryarchaeota,243NV@183968|Thermococci	183968|Thermococci	L	Putative modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
PYH1_k127_6402558_1	593750.Metfor_1008	1.897e-62	216.0	COG1892@1|root,arCOG04435@2157|Archaea,2XUGP@28890|Euryarchaeota,2NAY9@224756|Methanomicrobia	224756|Methanomicrobia	G	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle	ppcA	-	4.1.1.31	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00168,M00170,M00171,M00172,M00173,M00346,M00374	R00345	RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPcase_2
PYH1_k127_6402558_0	1459636.NTE_02809	2.263e-141	460.0	COG1915@1|root,arCOG04422@2157|Archaea,41SBQ@651137|Thaumarchaeota	651137|Thaumarchaeota	S	LOR SDH bifunctional	-	-	-	-	-	-	-	-	-	-	-	-	Saccharop_dh_N
PYH1_k127_6402558_2	673860.AciM339_0348	1.069e-39	164.0	COG0477@1|root,arCOG00130@2157|Archaea,2Y719@28890|Euryarchaeota,3F34W@33867|unclassified Euryarchaeota	28890|Euryarchaeota	G	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
PYH1_k127_6403048_3	985053.VMUT_0860	0.0002778	52.0	COG0468@1|root,arCOG00415@2157|Archaea,2XPN0@28889|Crenarchaeota	28889|Crenarchaeota	L	Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules	radA	GO:0000150,GO:0000217,GO:0000400,GO:0000724,GO:0000725,GO:0000730,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003697,GO:0003824,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006312,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022607,GO:0033554,GO:0034622,GO:0034641,GO:0042148,GO:0042623,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0045003,GO:0046483,GO:0050896,GO:0051716,GO:0065003,GO:0065004,GO:0071704,GO:0071824,GO:0071840,GO:0090304,GO:0090735,GO:0097159,GO:0140097,GO:1901360,GO:1901363	-	ko:K04483	-	-	-	-	ko00000,ko03400	-	-	-	HHH_5,Rad51
PYH1_k127_6403048_2	56780.SYN_03151	2.418e-25	111.0	COG0426@1|root,COG0426@2|Bacteria	2|Bacteria	C	nitric oxide reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red,GGDEF,HATPase_c,Lactamase_B,Response_reg
PYH1_k127_6403048_0	604354.TSIB_0718	9.018e-141	460.0	COG0477@1|root,arCOG00143@2157|Archaea,2Y8EH@28890|Euryarchaeota,245MX@183968|Thermococci	183968|Thermococci	G	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
PYH1_k127_6403048_1	552811.Dehly_1194	6.96e-81	273.0	COG1592@1|root,COG1592@2|Bacteria	2|Bacteria	C	Rubrerythrin	rbr	GO:0003674,GO:0005488,GO:0005506,GO:0043167,GO:0043169,GO:0046872,GO:0046914	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
PYH1_k127_6403751_0	1041930.Mtc_1026	7.034e-23	108.0	COG2047@1|root,arCOG00348@2157|Archaea,2XSX4@28890|Euryarchaeota,2N9I4@224756|Methanomicrobia	224756|Methanomicrobia	S	PAC2 family	-	-	-	ko:K07159	-	-	-	-	ko00000	-	-	-	PAC2
PYH1_k127_6403751_1	6500.XP_005092325.1	2.875e-18	86.0	COG1171@1|root,KOG1251@2759|Eukaryota,3AJVW@33154|Opisthokonta,3BZSW@33208|Metazoa,3DG6W@33213|Bilateria	33208|Metazoa	ET	Pyridoxal-phosphate dependent enzyme	-	-	-	-	-	-	-	-	-	-	-	-	PALP
PYH1_k127_6431950_0	589873.EP13_14005	8.083e-26	112.0	COG2819@1|root,COG2819@2|Bacteria,1R54Q@1224|Proteobacteria,1SAFU@1236|Gammaproteobacteria,468T4@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Putative esterase	-	-	-	ko:K07017	-	-	-	-	ko00000	-	-	-	Esterase
PYH1_k127_6431950_1	1284775.HMPREF1640_12120	0.0001107	55.0	COG4412@1|root,COG4412@2|Bacteria,4NF4S@976|Bacteroidetes,2FNJ2@200643|Bacteroidia	976|Bacteroidetes	N	M6 family metalloprotease domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M6
PYH1_k127_6437784_4	868131.MSWAN_1950	6.665e-37	143.0	COG0595@1|root,arCOG00547@2157|Archaea,2XTIB@28890|Euryarchaeota,23PHA@183925|Methanobacteria	183925|Methanobacteria	J	PFAM RNA-metabolising metallo-beta-lactamase	-	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B_2,RMMBL
PYH1_k127_6437784_3	1047013.AQSP01000144_gene917	2.156e-46	169.0	COG2044@1|root,COG2044@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K07092	-	-	-	-	ko00000	-	-	-	DrsE,DrsE_2
PYH1_k127_6437784_2	485914.Hmuk_0099	2.686e-49	190.0	COG1921@1|root,arCOG07389@2157|Archaea,2XU18@28890|Euryarchaeota,23SCH@183963|Halobacteria	183963|Halobacteria	E	COG1921 Selenocysteine synthase seryl-tRNASer selenium transferase	-	-	2.9.1.1	ko:K01042	ko00450,ko00970,map00450,map00970	-	R08219	RC01246	ko00000,ko00001,ko01000	-	-	-	Aminotran_5,SelA
PYH1_k127_6437784_1	1408473.JHXO01000001_gene2348	2.22e-53	192.0	COG0652@1|root,COG0652@2|Bacteria,4NRWP@976|Bacteroidetes,2FY2X@200643|Bacteroidia	976|Bacteroidetes	M	Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD	-	-	5.2.1.8	ko:K03767	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Pro_isomerase
PYH1_k127_6437784_0	1211819.CALK01000036_gene30	4.612e-72	263.0	COG3653@1|root,COG3653@2|Bacteria,1TSGD@1239|Firmicutes	1239|Firmicutes	Q	PFAM D-aminoacylase	dan	-	3.5.1.81	ko:K06015	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
PYH1_k127_6442911_3	1123242.JH636434_gene4429	1.832e-14	76.0	COG0154@1|root,COG0154@2|Bacteria,2IY50@203682|Planctomycetes	203682|Planctomycetes	J	Amidase	-	-	-	-	-	-	-	-	-	-	-	-	Amidase
PYH1_k127_6442911_0	1121472.AQWN01000002_gene2174	1.607e-69	242.0	COG0605@1|root,COG0605@2|Bacteria,1TPXT@1239|Firmicutes,24HDS@186801|Clostridia,260SB@186807|Peptococcaceae	186801|Clostridia	P	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	sodA	-	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
PYH1_k127_6442911_1	877455.Metbo_0521	2.334e-43	167.0	COG0170@1|root,arCOG01880@2157|Archaea,2XY6G@28890|Euryarchaeota,23PK0@183925|Methanobacteria	183925|Methanobacteria	I	PFAM phosphatidate cytidylyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_6442911_2	1220534.B655_1828	7.043e-38	149.0	COG0125@1|root,arCOG01893@2157|Archaea,2XZ7Z@28890|Euryarchaeota,23PMA@183925|Methanobacteria	183925|Methanobacteria	F	thymidylate kinase	-	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
PYH1_k127_644486_2	644282.Deba_1042	9.643e-29	120.0	COG0585@1|root,COG0585@2|Bacteria,1MXHD@1224|Proteobacteria,42P4E@68525|delta/epsilon subdivisions,2WN09@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs	truD	GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0016070,GO:0016853,GO:0016866,GO:0034641,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360	5.4.99.27	ko:K06176	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruD
PYH1_k127_644486_1	415426.Hbut_0906	2.418e-63	235.0	COG0470@1|root,arCOG00470@2157|Archaea,2XPN9@28889|Crenarchaeota	28889|Crenarchaeota	L	Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA	rfcL	-	-	ko:K04800	ko03030,map03030	-	-	-	ko00000,ko00001,ko03032	-	-	-	AAA,RFC1,Rad17
PYH1_k127_644486_0	323259.Mhun_0994	3.852e-88	301.0	COG0470@1|root,arCOG00469@2157|Archaea,2XTC8@28890|Euryarchaeota,2N91S@224756|Methanomicrobia	224756|Methanomicrobia	L	Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA	rfcS	-	-	ko:K04801	ko03030,map03030	-	-	-	ko00000,ko00001,ko03032	-	-	-	AAA,DNA_pol3_delta2,Rad17,Rep_fac_C
PYH1_k127_6457240_0	1499967.BAYZ01000177_gene5729	1.067e-45	175.0	COG0207@1|root,COG0207@2|Bacteria	2|Bacteria	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis	thyA	-	2.1.1.45	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylat_synt
PYH1_k127_6469305_0	529709.PYCH_07630	2.571e-24	108.0	COG1522@1|root,arCOG01580@2157|Archaea,2XXGY@28890|Euryarchaeota,243ZR@183968|Thermococci	183968|Thermococci	K	transcription regulator activity	-	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K03718	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
PYH1_k127_6469305_2	1238186.AOCN01000015_gene1008	2.443e-07	58.0	COG0730@1|root,COG0730@2|Bacteria,2I5VT@201174|Actinobacteria,4FMK5@85023|Microbacteriaceae	201174|Actinobacteria	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
PYH1_k127_6469305_1	1131266.ARWQ01000006_gene231	3.896e-21	101.0	COG0265@1|root,arCOG02833@2157|Archaea,41S9W@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Trypsin-like serine protease with C-terminal PDZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
PYH1_k127_6472265_6	1365176.N186_01815	2.397e-05	49.0	COG0746@1|root,arCOG01872@2157|Archaea,2XRJV@28889|Crenarchaeota	28889|Crenarchaeota	H	MobA-like NTP transferase domain	mobA	-	2.7.7.77	ko:K03752	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
PYH1_k127_6472265_0	374847.Kcr_1078	1.247e-160	519.0	COG0516@1|root,arCOG00612@2157|Archaea	2157|Archaea	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	GO:0003674,GO:0003824,GO:0003938,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	1.1.1.205,1.7.1.7	ko:K00088,ko:K00364	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R01134,R08240	RC00143,RC00457,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
PYH1_k127_6472265_2	81824.XP_001745244.1	2.442e-55	200.0	COG0138@1|root,KOG2555@2759|Eukaryota,38H8U@33154|Opisthokonta	33154|Opisthokonta	F	IMP cyclohydrolase activity	-	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
PYH1_k127_6472265_1	662479.C440_14264	1.341e-74	263.0	COG0138@1|root,arCOG02824@2157|Archaea,2XT5P@28890|Euryarchaeota,23SVD@183963|Halobacteria	183963|Halobacteria	F	COG0299 Folate-dependent phosphoribosylglycinamide formyltransferase PurN	purNH	-	2.1.2.2,2.1.2.3	ko:K01492	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R01127,R04325,R04326,R04560	RC00026,RC00197,RC00263,RC00456,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	AICARFT_IMPCHas,Formyl_trans_N
PYH1_k127_6472265_5	521045.Kole_0515	1.036e-14	78.0	COG1765@1|root,COG1765@2|Bacteria,2GE9P@200918|Thermotogae	200918|Thermotogae	O	Protein of unknown function (DUF3795)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3795
PYH1_k127_6472265_4	926556.Echvi_0116	1.615e-19	102.0	COG2235@1|root,COG2235@2|Bacteria,4NHKZ@976|Bacteroidetes,47JM7@768503|Cytophagia	976|Bacteroidetes	E	Arginine deiminase	-	-	3.5.3.6	ko:K01478	ko00220,ko01100,ko01110,ko01130,map00220,map01100,map01110,map01130	-	R00552	RC00177	ko00000,ko00001,ko01000	-	-	-	Amidinotransf
PYH1_k127_6472265_3	1408303.JNJJ01000020_gene4058	3.482e-25	112.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1TR2N@1239|Firmicutes,4H9RR@91061|Bacilli,1ZB2Q@1386|Bacillus	91061|Bacilli	EU	peptidase	yuxL	-	3.4.19.1	ko:K01303	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,Peptidase_S9
PYH1_k127_6489673_0	247490.KSU1_C0430	2.556e-28	129.0	COG1216@1|root,COG1216@2|Bacteria	2|Bacteria	V	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,Glyphos_transf,NTP_transf_5,RgpF
PYH1_k127_6494786_1	1459636.NTE_01581	2.334e-82	286.0	COG0624@1|root,arCOG01107@2157|Archaea,41SAX@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Catalyzes the release of L-lysine from LysW -gamma-L- lysine and the release of L-ornithine from LysW -L-ornithine	lysK	-	-	ko:K05831	ko00220,ko00300,ko01100,ko01210,ko01230,map00220,map00300,map01100,map01210,map01230	M00031,M00763	R09779,R10933	RC00064,RC00090	ko00000,ko00001,ko00002	-	-	-	M20_dimer,Peptidase_M20
PYH1_k127_6494786_0	1229909.NSED_07165	5.298e-118	391.0	COG4992@1|root,arCOG00914@2157|Archaea,41SC8@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	lysJ	-	-	ko:K05830	ko00220,ko00300,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01130,map01210,map01230	M00031,M00763	R09778,R10932	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
PYH1_k127_6494786_2	1229909.NSED_07160	3.767e-09	59.0	COG0548@1|root,arCOG00862@2157|Archaea,41SFB@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis)	lysZ	-	-	ko:K05828	ko00220,ko00300,ko01100,ko01110,ko01210,ko01230,map00220,map00300,map01100,map01110,map01210,map01230	M00031,M00763	R09776,R10930	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
PYH1_k127_6509562_1	1459636.NTE_00656	7.035e-113	371.0	COG0104@1|root,arCOG04387@2157|Archaea,41SCA@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
PYH1_k127_6509562_2	383372.Rcas_3269	8.563e-53	196.0	COG1058@1|root,COG1058@2|Bacteria,2G6DU@200795|Chloroflexi,374WE@32061|Chloroflexia	2|Bacteria	S	PFAM molybdopterin binding domain	cinA	-	3.5.1.42	ko:K03742	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA,MoCF_biosynth
PYH1_k127_6509562_0	351160.RCIX575	2.067e-132	436.0	COG1204@1|root,arCOG00553@2157|Archaea,2XSV4@28890|Euryarchaeota,2N9A8@224756|Methanomicrobia	224756|Methanomicrobia	L	DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks	hel308	-	-	ko:K03726	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HHH_5,Helicase_C
PYH1_k127_6520467_0	1411685.U062_00983	1.96e-19	98.0	COG0568@1|root,COG0568@2|Bacteria,1MUDI@1224|Proteobacteria,1RN8V@1236|Gammaproteobacteria,1J4VY@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	K	COG0568 DNA-directed RNA polymerase, sigma subunit	rpoS	GO:0000988,GO:0000990,GO:0001000,GO:0001121,GO:0001123,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016987,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019899,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043175,GO:0043254,GO:0044087,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2000142,GO:2001141	-	ko:K03087	ko02026,ko05111,map02026,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
PYH1_k127_6521297_2	526227.Mesil_1127	9.722e-11	66.0	2CAQ4@1|root,33YR3@2|Bacteria,1WMW6@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_6521297_1	290397.Adeh_3049	3.969e-43	162.0	COG2606@1|root,COG2606@2|Bacteria,1RGX5@1224|Proteobacteria,42RNH@68525|delta/epsilon subdivisions,2X5NY@28221|Deltaproteobacteria,2Z0TQ@29|Myxococcales	28221|Deltaproteobacteria	H	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily	-	-	-	ko:K03976	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_edit
PYH1_k127_6521297_0	1211035.CD30_16035	3.547e-123	410.0	COG0402@1|root,COG0402@2|Bacteria,1TP43@1239|Firmicutes,4HBV3@91061|Bacilli	91061|Bacilli	F	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine	-	-	3.5.4.28,3.5.4.31	ko:K12960	ko00270,ko01100,map00270,map01100	-	R09660	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
PYH1_k127_654368_2	1131266.ARWQ01000015_gene762	3.317e-36	146.0	COG1005@1|root,arCOG01546@2157|Archaea,41SAT@651137|Thaumarchaeota	651137|Thaumarchaeota	C	NADH dehydrogenase	-	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
PYH1_k127_654368_0	374847.Kcr_0139	1.173e-87	302.0	COG0649@1|root,arCOG01548@2157|Archaea	2157|Archaea	C	COG0852 NADH ubiquinone oxidoreductase 27 kD subunit	nuoD	-	1.1.98.4,1.6.5.3	ko:K00333,ko:K13378,ko:K22172,ko:K22173	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
PYH1_k127_654368_3	1163730.FFONT_1350	5.946e-22	101.0	COG0852@1|root,arCOG01551@2157|Archaea,2XR17@28889|Crenarchaeota	28889|Crenarchaeota	C	PFAM NADH dehydrogenase (ubiquinone), 30 kDa subunit	nuoC	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
PYH1_k127_654368_1	1120973.AQXL01000132_gene2179	2.658e-43	163.0	COG0377@1|root,COG0377@2|Bacteria,1TZS1@1239|Firmicutes,4HACH@91061|Bacilli,277Y1@186823|Alicyclobacillaceae	91061|Bacilli	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoB	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
PYH1_k127_654368_5	926569.ANT_10410	0.0007114	47.0	COG0838@1|root,COG0838@2|Bacteria,2G71E@200795|Chloroflexi	200795|Chloroflexi	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoA	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0050136,GO:0055114,GO:0098796,GO:1902494	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
PYH1_k127_654368_4	351160.RRC234	2.134e-15	87.0	COG1522@1|root,arCOG01585@2157|Archaea,2Y7PY@28890|Euryarchaeota	28890|Euryarchaeota	K	helix_turn_helix ASNC type	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
PYH1_k127_6548320_3	1296415.JACC01000039_gene4003	1.358e-32	145.0	COG3049@1|root,COG3049@2|Bacteria,4NIRM@976|Bacteroidetes,1I5FU@117743|Flavobacteriia	976|Bacteroidetes	M	Linear amide C-N hydrolases, choloylglycine hydrolase family	-	-	3.5.1.24	ko:K01442	ko00120,ko00121,ko01100,map00120,map00121,map01100	-	R02797,R03975,R03977,R04486,R04487,R05835	RC00090,RC00096	ko00000,ko00001,ko01000	-	-	-	AAT,AMPK1_CBM,CBAH
PYH1_k127_6548320_0	1403313.AXBR01000007_gene177	9.519e-76	264.0	COG1234@1|root,COG1234@2|Bacteria,1TXGA@1239|Firmicutes,4I6F1@91061|Bacilli,1ZNS8@1386|Bacillus	91061|Bacilli	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
PYH1_k127_6548320_1	331678.Cphamn1_1562	8.7e-43	164.0	COG1680@1|root,COG1680@2|Bacteria,1FF57@1090|Chlorobi	1090|Chlorobi	V	Fibrobacter succinogenes major domain (Fib_succ_major)	-	-	-	-	-	-	-	-	-	-	-	-	Fib_succ_major
PYH1_k127_6548320_2	981384.AEYW01000004_gene1937	2.078e-34	137.0	COG0076@1|root,COG0076@2|Bacteria,1MWUX@1224|Proteobacteria,2TTUK@28211|Alphaproteobacteria,4ND3P@97050|Ruegeria	28211|Alphaproteobacteria	E	Pyridoxal-dependent decarboxylase conserved domain	-	-	-	-	-	-	-	-	-	-	-	-	Pyridoxal_deC
PYH1_k127_6573732_1	391623.TERMP_01340	1.299e-33	137.0	COG0382@1|root,arCOG00476@2157|Archaea,2Y84C@28890|Euryarchaeota,243VS@183968|Thermococci	183968|Thermococci	H	UbiA prenyltransferase family	-	-	-	ko:K20616	-	-	-	-	ko00000	-	-	-	UbiA
PYH1_k127_6573732_0	1173021.ALWA01000037_gene3492	1.337e-47	181.0	COG0436@1|root,COG0436@2|Bacteria	2|Bacteria	E	Aminotransferase	-	-	2.6.1.1,4.4.1.8	ko:K00812,ko:K10907,ko:K14155	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00450,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00450,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00782,R00896,R01286,R02408,R02433,R02619,R04941,R05052	RC00006,RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
PYH1_k127_6585585_1	192952.MM_2504	2.261e-48	178.0	COG0484@1|root,arCOG02846@2157|Archaea,2XV5D@28890|Euryarchaeota,2N95Q@224756|Methanomicrobia	224756|Methanomicrobia	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
PYH1_k127_6585585_0	247490.KSU1_C1370	7.693e-231	730.0	COG0443@1|root,COG0443@2|Bacteria,2IWWS@203682|Planctomycetes	203682|Planctomycetes	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
PYH1_k127_6585585_2	1122917.KB899659_gene5596	9.737e-23	100.0	COG0576@1|root,COG0576@2|Bacteria,1V6G2@1239|Firmicutes,4HIRK@91061|Bacilli,26X19@186822|Paenibacillaceae	91061|Bacilli	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	GO:0000166,GO:0000774,GO:0001871,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0008150,GO:0009986,GO:0017076,GO:0030234,GO:0030246,GO:0030247,GO:0030554,GO:0036094,GO:0044464,GO:0050790,GO:0051082,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0097159,GO:0098772,GO:1901265,GO:1901363,GO:2001065	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
PYH1_k127_6602446_1	1220534.B655_1468	9.317e-66	231.0	COG1355@1|root,arCOG01728@2157|Archaea,2XVYU@28890|Euryarchaeota,23P13@183925|Methanobacteria	183925|Methanobacteria	S	Belongs to the MEMO1 family	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
PYH1_k127_6602446_0	1184251.TCELL_0535	1.939e-66	232.0	COG0052@1|root,arCOG04245@2157|Archaea,2XPP9@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the universal ribosomal protein uS2 family	rps2	GO:0000028,GO:0000447,GO:0000460,GO:0000461,GO:0000462,GO:0000466,GO:0000469,GO:0000478,GO:0000479,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0031123,GO:0031125,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043628,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
PYH1_k127_6602446_2	391623.TERMP_00135	8.549e-28	114.0	COG1644@1|root,arCOG04244@2157|Archaea,2Y03I@28890|Euryarchaeota,244I0@183968|Thermococci	183968|Thermococci	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoN	GO:0000428,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0008270,GO:0030880,GO:0032991,GO:0043167,GO:0043169,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03058	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_N
PYH1_k127_6602446_3	868131.MSWAN_0457	4.804e-11	68.0	COG1369@1|root,arCOG01365@2157|Archaea,2Y78B@28890|Euryarchaeota,23P8M@183925|Methanobacteria	183925|Methanobacteria	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp2	-	3.1.26.5	ko:K03537	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03016,ko03029	-	-	-	RNase_P_Rpp14
PYH1_k127_6602446_4	1132509.C447_06471	0.0007178	45.0	COG1603@1|root,arCOG00307@2157|Archaea,2XU7Q@28890|Euryarchaeota,23TGE@183963|Halobacteria	183963|Halobacteria	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp3	-	3.1.26.5	ko:K03539	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03016,ko03029	-	-	-	RNase_P_p30
PYH1_k127_6606830_0	35128.Thapsdraft1267	0.0	1003.0	COG0085@1|root,KOG0214@2759|Eukaryota,2XEM3@2836|Bacillariophyta	2836|Bacillariophyta	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	-	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009536,GO:0030880,GO:0032991,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0061695,GO:1902494,GO:1990234	-	-	-	-	-	-	-	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
PYH1_k127_6624289_0	1196322.A370_00282	8.307e-23	109.0	COG1834@1|root,COG1834@2|Bacteria,1VDT8@1239|Firmicutes,25EE3@186801|Clostridia,36UMK@31979|Clostridiaceae	186801|Clostridia	E	Amidinotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Amidinotransf
PYH1_k127_6624289_1	985053.VMUT_0553	1.938e-13	73.0	COG0006@1|root,arCOG01000@2157|Archaea	2157|Archaea	E	Belongs to the peptidase M24B family	-	-	-	-	-	-	-	-	-	-	-	-	Creatinase_N,Peptidase_M24
PYH1_k127_6651869_0	1047013.AQSP01000126_gene2740	0.0	1023.0	COG2866@1|root,COG2866@2|Bacteria,2NQNH@2323|unclassified Bacteria	2|Bacteria	E	Zinc carboxypeptidase	-	-	-	ko:K14054	-	-	-	-	ko00000	-	-	-	AstE_AspA,Peptidase_M14
PYH1_k127_6707046_1	580331.Thit_2333	9.125e-95	318.0	COG1155@1|root,COG1155@2|Bacteria,1TPGS@1239|Firmicutes,24882@186801|Clostridia,42ETB@68295|Thermoanaerobacterales	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit	-	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
PYH1_k127_6707046_4	318464.IO99_06215	1.232e-06	58.0	COG1390@1|root,COG1390@2|Bacteria,1VEEA@1239|Firmicutes,24QMH@186801|Clostridia,36J88@31979|Clostridiaceae	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpE	-	-	ko:K02121	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_E
PYH1_k127_6707046_0	1131266.ARWQ01000015_gene758	9.664e-123	410.0	COG0651@1|root,arCOG01537@2157|Archaea,41SAV@651137|Thaumarchaeota	651137|Thaumarchaeota	C	plastoquinone (complex I)	-	-	1.6.5.3	ko:K00342,ko:K12137,ko:K12141	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
PYH1_k127_6707046_3	555779.Dthio_PD1228	1.013e-06	56.0	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,42KZE@68525|delta/epsilon subdivisions,2WIPT@28221|Deltaproteobacteria,2MG3C@213115|Desulfovibrionales	28221|Deltaproteobacteria	CP	NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein	nuoL-2	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_C,Proton_antipo_M,Proton_antipo_N
PYH1_k127_6719909_1	985053.VMUT_0604	1.524e-20	99.0	arCOG03727@1|root,arCOG03727@2157|Archaea	2157|Archaea	-	-	-	-	2.7.7.7	ko:K02339	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	Mrr_cat,NERD
PYH1_k127_6719909_0	865861.AZSU01000002_gene3052	8.162e-116	384.0	COG1228@1|root,COG1228@2|Bacteria,1TPNQ@1239|Firmicutes,248UT@186801|Clostridia,36E56@31979|Clostridiaceae	186801|Clostridia	Q	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,Amidohydro_3
PYH1_k127_6719909_2	391623.TERMP_00788	1.237e-16	80.0	COG2414@1|root,arCOG00707@2157|Archaea,2XW66@28890|Euryarchaeota,245F8@183968|Thermococci	183968|Thermococci	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
PYH1_k127_6732108_0	257310.BB0514	5.975e-50	187.0	COG3181@1|root,COG3181@2|Bacteria,1N1ND@1224|Proteobacteria,2VKD0@28216|Betaproteobacteria,3T5SD@506|Alcaligenaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
PYH1_k127_6732108_1	1125863.JAFN01000001_gene2648	2.416e-29	121.0	COG1142@1|root,COG1142@2|Bacteria,1MWE1@1224|Proteobacteria,42TQV@68525|delta/epsilon subdivisions,2WQAE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_11,Fer4_4,Fer4_7
PYH1_k127_6732108_2	632292.Calhy_0499	1.198e-22	101.0	COG1414@1|root,COG1414@2|Bacteria,1TRMW@1239|Firmicutes,24BQA@186801|Clostridia,42G3H@68295|Thermoanaerobacterales	186801|Clostridia	K	Transcriptional regulator IclR	-	-	-	ko:K13641	-	-	-	-	ko00000,ko03000	-	-	-	HTH_IclR,IclR
PYH1_k127_6737499_0	338966.Ppro_3524	1.268e-131	430.0	COG3261@1|root,COG3261@2|Bacteria,1QUBF@1224|Proteobacteria,43DST@68525|delta/epsilon subdivisions,2WJ4E@28221|Deltaproteobacteria,43TGG@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	PFAM NADH-ubiquinone oxidoreductase, chain 49kDa	-	-	1.6.5.3	ko:K00333,ko:K14090	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa,NiFeSe_Hases
PYH1_k127_6737499_2	1123376.AUIU01000014_gene589	1.524e-16	85.0	COG0852@1|root,COG3261@1|root,COG0852@2|Bacteria,COG3261@2|Bacteria,3J0W2@40117|Nitrospirae	40117|Nitrospirae	C	Respiratory-chain NADH dehydrogenase, 30 Kd subunit	-	-	-	-	-	-	-	-	-	-	-	-	Complex1_30kDa,Complex1_49kDa,NiFeSe_Hases
PYH1_k127_6737499_1	387631.Asulf_01800	3.85e-36	138.0	COG0377@1|root,arCOG01554@2157|Archaea,2XTP1@28890|Euryarchaeota	28890|Euryarchaeota	C	Belongs to the complex I 20 kDa subunit family	nuoB	-	1.5.98.3,1.6.5.3	ko:K00331,ko:K22159	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1,3.D.9.1	-	-	Oxidored_q6
PYH1_k127_677554_3	565033.GACE_0072	1.246e-16	83.0	COG0644@1|root,arCOG00570@2157|Archaea,2XU3J@28890|Euryarchaeota,245QU@183980|Archaeoglobi	183980|Archaeoglobi	C	Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains	-	-	1.3.1.101,1.3.7.11	ko:K17830	ko00564,map00564	-	R10325,R10326,R10331	RC03134	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3
PYH1_k127_677554_4	1183377.Py04_1713	1.45e-14	75.0	COG2036@1|root,arCOG02144@2157|Archaea,2XZYK@28890|Euryarchaeota,244HP@183968|Thermococci	183968|Thermococci	L	Binds and compact DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils. Increases the resistance of DNA to thermal denaturation	-	-	-	-	-	-	-	-	-	-	-	-	CBFD_NFYB_HMF
PYH1_k127_677554_5	186497.PF1491	3.049e-13	72.0	COG1383@1|root,arCOG01885@2157|Archaea,2Y07I@28890|Euryarchaeota,244GA@183968|Thermococci	183968|Thermococci	J	Belongs to the eukaryotic ribosomal protein eS17 family	rps17e	GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02962	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17e
PYH1_k127_677554_1	633148.Tagg_1147	6.906e-51	191.0	COG1475@1|root,arCOG01875@2157|Archaea,2XR7V@28889|Crenarchaeota	28889|Crenarchaeota	K	PFAM ParB domain protein nuclease	-	-	-	-	-	-	-	-	-	-	-	-	ParBc
PYH1_k127_677554_2	224325.AF_0239	7.192e-32	132.0	COG2236@1|root,arCOG00040@2157|Archaea,2XYCC@28890|Euryarchaeota,247HC@183980|Archaeoglobi	183980|Archaeoglobi	F	Phosphoribosyl transferase domain	-	-	-	ko:K07101	-	-	-	-	ko00000	-	-	-	Pribosyltran
PYH1_k127_677554_0	1459636.NTE_03482	2.104e-54	202.0	COG0330@1|root,arCOG01915@2157|Archaea,41SYP@651137|Thaumarchaeota	651137|Thaumarchaeota	O	PFAM SPFH domain Band 7 family	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
PYH1_k127_677554_6	1459636.NTE_02718	8.746e-12	65.0	COG1056@1|root,arCOG00972@2157|Archaea,41T7B@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Cytidylyltransferase-like	-	-	2.7.7.1	ko:K00952	ko00760,ko01100,map00760,map01100	-	R00137,R03005	RC00002	ko00000,ko00001,ko01000	-	-	-	CTP_transf_like
PYH1_k127_6795739_2	102129.Lepto7375DRAFT_8055	8.137e-30	125.0	28XBK@1|root,2ZJ9G@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_6795739_1	547144.HydHO_0636	1.309e-54	196.0	COG1793@1|root,COG1793@2|Bacteria	2|Bacteria	L	dna ligase	ligD	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
PYH1_k127_6795739_0	865861.AZSU01000003_gene2198	1.766e-114	379.0	COG3199@1|root,COG3199@2|Bacteria,1UAMM@1239|Firmicutes,249JW@186801|Clostridia,36GFM@31979|Clostridiaceae	186801|Clostridia	S	Diacylglycerol kinase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	NAD_kinase
PYH1_k127_6798356_1	572546.Arcpr_0637	1.761e-17	89.0	COG1138@1|root,arCOG00268@2157|Archaea	2157|Archaea	O	PFAM Cytochrome c assembly protein	-	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	Cytochrom_C_asm
PYH1_k127_6798356_0	589924.Ferp_0957	9.322e-47	176.0	COG0755@1|root,arCOG00267@2157|Archaea,2XXKZ@28890|Euryarchaeota,2468C@183980|Archaeoglobi	183980|Archaeoglobi	O	ABC-type transport system involved in cytochrome c biogenesis permease component	-	-	-	ko:K02195	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	Cytochrom_C_asm
PYH1_k127_6798356_2	562970.Btus_2648	2.904e-10	67.0	COG2332@1|root,COG2332@2|Bacteria,1VJ83@1239|Firmicutes,4HPSQ@91061|Bacilli,27A3Z@186823|Alicyclobacillaceae	91061|Bacilli	O	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH	-	-	-	ko:K02197	-	-	-	-	ko00000	-	-	-	CcmE
PYH1_k127_6798356_3	582744.Msip34_0260	1.488e-08	56.0	COG1131@1|root,COG1131@2|Bacteria,1MUW7@1224|Proteobacteria,2VI81@28216|Betaproteobacteria,2KKJG@206350|Nitrosomonadales	206350|Nitrosomonadales	V	PFAM ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
PYH1_k127_6830454_0	1123376.AUIU01000019_gene1235	1.564e-38	152.0	COG2220@1|root,COG2220@2|Bacteria	2|Bacteria	S	N-acetylphosphatidylethanolamine-hydrolysing phospholipas activity	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
PYH1_k127_6907586_2	523845.AQXV01000043_gene256	6.098e-23	102.0	COG0674@1|root,arCOG01608@2157|Archaea,2XTB0@28890|Euryarchaeota,23RHJ@183939|Methanococci	183939|Methanococci	C	Pyruvate:ferredoxin oxidoreductase core domain II	-	-	1.2.7.1	ko:K00169	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
PYH1_k127_6907586_0	374847.Kcr_1293	3.273e-76	265.0	COG1013@1|root,arCOG01601@2157|Archaea	2157|Archaea	C	PFAM Thiamine pyrophosphate	vorB	-	1.2.7.1,1.2.7.7	ko:K00170,ko:K00187	ko00010,ko00020,ko00280,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00280,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R07160,R08034,R08566,R08567	RC00004,RC00250,RC02742,RC02833,RC02856	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
PYH1_k127_6907586_1	1459636.NTE_01818	1.605e-28	119.0	arCOG05900@1|root,arCOG05900@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,LexA_DNA_bind
PYH1_k127_6910464_4	1365176.N186_01615	3.359e-05	47.0	COG1801@1|root,arCOG04291@2157|Archaea	2157|Archaea	L	DUF72 domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
PYH1_k127_6910464_1	1343739.PAP_02225	1.656e-30	131.0	COG1650@1|root,arCOG01616@2157|Archaea,2XUM0@28890|Euryarchaeota,243DT@183968|Thermococci	183968|Thermococci	J	D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo	dtdA	-	3.1.1.96	ko:K09716	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_deacylase
PYH1_k127_6910464_0	456442.Mboo_2448	5.705e-92	312.0	COG3276@1|root,arCOG01564@2157|Archaea,2XWBV@28890|Euryarchaeota,2N945@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM elongation factor Tu domain 2	-	-	-	-	-	-	-	-	-	-	-	-	GTP_EFTU_D2
PYH1_k127_6910464_3	1131266.ARWQ01000002_gene486	1.983e-10	63.0	arCOG05330@1|root,arCOG05330@2157|Archaea,41SUC@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_6910464_2	272844.PAB0759	1.712e-11	65.0	COG2102@1|root,arCOG00035@2157|Archaea,2XTNJ@28890|Euryarchaeota,242TE@183968|Thermococci	183968|Thermococci	S	Diphthamide synthase	-	-	6.3.1.14	ko:K06927	-	-	R03613	RC00358	ko00000,ko01000,ko03012	-	-	-	Diphthami_syn_2
PYH1_k127_6942279_2	439481.Aboo_1538	7.617e-91	308.0	COG1109@1|root,arCOG00767@2157|Archaea,2XT1X@28890|Euryarchaeota,3F2G6@33867|unclassified Euryarchaeota	28890|Euryarchaeota	G	phosphoglucomutase phosphomannomutase alpha beta alpha domain I	pmm4	-	5.4.2.2,5.4.2.8	ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A2225	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
PYH1_k127_6942279_4	1133850.SHJG_2805	1.9e-69	248.0	COG1109@1|root,COG1208@1|root,COG1109@2|Bacteria,COG1208@2|Bacteria,2GKTE@201174|Actinobacteria	201174|Actinobacteria	JM	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B gamma epsilon subunits	-	-	2.7.7.13,5.4.2.8	ko:K16881	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114,M00362	R00885,R01818	RC00002,RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase,PGM_PMM_I,PGM_PMM_II,PGM_PMM_III
PYH1_k127_6942279_3	368408.Tpen_0113	3.349e-77	265.0	COG1208@1|root,arCOG00663@2157|Archaea,2XQ9B@28889|Crenarchaeota	28889|Crenarchaeota	M	COGs COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B gamma epsilon subunits (eIF-2Bgamma eIF-2Bepsilon)	-	-	2.7.7.13	ko:K00966	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
PYH1_k127_6942279_0	1131266.ARWQ01000005_gene788	1.425e-130	426.0	COG1697@1|root,arCOG04143@2157|Archaea,41SQF@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Relaxes both positive and negative superturns and exhibits a strong decatenase activity	top6A	-	5.99.1.3	ko:K03166	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	TP6A_N
PYH1_k127_6942279_1	374847.Kcr_1451	1.406e-129	432.0	COG1389@1|root,arCOG01165@2157|Archaea	2157|Archaea	L	Relaxes both positive and negative superturns and exhibits a strong decatenase activity	top6B	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	5.99.1.3	ko:K03167	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	HATPase_c,HATPase_c_3,Topo-VIb_trans
PYH1_k127_6942279_6	402880.MmarC5_1001	4.965e-44	168.0	COG1094@1|root,arCOG04150@2157|Archaea,2XUHX@28890|Euryarchaeota,23QSQ@183939|Methanococci	183939|Methanococci	J	SMART KH domain protein	-	-	-	ko:K06961	-	-	-	-	ko00000,ko03009	-	-	-	KH_1
PYH1_k127_6942279_5	304371.MCP_1531	9.122e-60	216.0	COG1718@1|root,arCOG01180@2157|Archaea,2XU2H@28890|Euryarchaeota,2N9ET@224756|Methanomicrobia	224756|Methanomicrobia	T	serine threonine protein kinase	-	-	2.7.11.1	ko:K07178	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko01001,ko03009	-	-	-	RIO1
PYH1_k127_6942279_7	1131266.ARWQ01000005_gene783	8.199e-25	108.0	COG0361@1|root,arCOG01179@2157|Archaea,41SRK@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits	-	-	-	ko:K03236	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	eIF-1a
PYH1_k127_6942279_8	926561.KB900617_gene1231	6.835e-21	94.0	COG1489@1|root,COG1489@2|Bacteria,1V1GZ@1239|Firmicutes,24A0M@186801|Clostridia,3WBSY@53433|Halanaerobiales	186801|Clostridia	S	Sugar fermentation stimulation protein	sfsA	-	-	ko:K06206	-	-	-	-	ko00000	-	-	-	SfsA
PYH1_k127_6957464_3	748727.CLJU_c24620	0.0005693	43.0	COG2320@1|root,COG2320@2|Bacteria,1V3IB@1239|Firmicutes,24F56@186801|Clostridia,36VN9@31979|Clostridiaceae	186801|Clostridia	S	GrpB protein	-	-	-	-	-	-	-	-	-	-	-	-	GrpB
PYH1_k127_6957464_2	392499.Swit_4779	1.053e-39	151.0	2F7GP@1|root,33FS5@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_6957464_0	589924.Ferp_2133	5.521e-119	401.0	COG0072@1|root,arCOG00412@2157|Archaea,2XTD5@28890|Euryarchaeota,245T6@183980|Archaeoglobi	183980|Archaeoglobi	J	phenylalanyl-tRNA synthetase, beta subunit	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5
PYH1_k127_6957464_1	386456.JQKN01000002_gene2422	9.083e-95	320.0	COG0016@1|root,arCOG00410@2157|Archaea,2XSTK@28890|Euryarchaeota,23NUT@183925|Methanobacteria	183925|Methanobacteria	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2d
PYH1_k127_7023587_2	224719.Abm4_0721	1.956e-14	74.0	COG1998@1|root,arCOG04183@2157|Archaea,2XZZ0@28890|Euryarchaeota,23PUT@183925|Methanobacteria	183925|Methanobacteria	J	Belongs to the eukaryotic ribosomal protein eS31 family	rps27ae	-	-	ko:K02977	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko04147	-	-	-	Ribosomal_S27
PYH1_k127_7023587_5	694429.Pyrfu_0747	1.116e-08	60.0	COG2004@1|root,arCOG04182@2157|Archaea,2XR07@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eS24 family	rps24e	-	-	ko:K02974	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S24e
PYH1_k127_7023587_1	1343739.PAP_00780	7.611e-28	119.0	COG1909@1|root,arCOG04076@2157|Archaea,2XXSG@28890|Euryarchaeota,2440N@183968|Thermococci	183968|Thermococci	S	Belongs to the UPF0218 family	-	-	-	ko:K09735	-	-	-	-	ko00000	-	-	-	DUF359
PYH1_k127_7023587_3	573063.Metin_1062	1.637e-09	60.0	COG2093@1|root,arCOG04077@2157|Archaea,2Y0YK@28890|Euryarchaeota,23R8G@183939|Methanococci	183939|Methanococci	K	Transcription elongation factor Spt4	spt4	-	2.7.7.6	ko:K03050	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	Spt4
PYH1_k127_7023587_0	436308.Nmar_1235	1.243e-58	209.0	COG1095@1|root,arCOG00675@2157|Archaea,41SGF@651137|Thaumarchaeota	651137|Thaumarchaeota	K	DNA-directed RNA polymerase	-	-	2.7.7.6	ko:K03049	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	S1,SHS2_Rpb7-N
PYH1_k127_7023587_4	1151117.AJLF01000001_gene753	8.316e-09	59.0	COG0503@1|root,arCOG00031@2157|Archaea,2XTD2@28890|Euryarchaeota,242RK@183968|Thermococci	183968|Thermococci	F	Phosphoribosyl transferase domain	-	-	2.4.2.7	ko:K00759,ko:K09685	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko03000,ko04147	-	-	-	HTH_3,Pribosyltran
PYH1_k127_7025041_0	1343739.PAP_00235	5.386e-37	145.0	COG1637@1|root,arCOG01304@2157|Archaea,2XUC8@28890|Euryarchaeota,243KJ@183968|Thermococci	183968|Thermococci	L	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures	nucS	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K07503	-	-	-	-	ko00000,ko01000	-	-	-	NucS
PYH1_k127_7034302_2	1459636.NTE_01416	6.093e-06	48.0	COG2450@1|root,arCOG02263@2157|Archaea,41T6T@651137|Thaumarchaeota	651137|Thaumarchaeota	D	Pfam:DUF552	-	-	-	ko:K09152	-	-	-	-	ko00000	-	-	-	SepF
PYH1_k127_7034302_0	186497.PF1405	5.197e-202	647.0	COG1782@1|root,arCOG00543@2157|Archaea,2XTIM@28890|Euryarchaeota,243E8@183968|Thermococci	183968|Thermococci	S	Beta-Casp domain	-	-	-	ko:K07041	-	-	-	-	ko00000	-	-	-	Beta-Casp,KH_7,Lactamase_B,Lactamase_B_6,RMMBL
PYH1_k127_7034302_1	192952.MM_0694	4.608e-54	196.0	COG0638@1|root,arCOG00970@2157|Archaea,2XUIZ@28890|Euryarchaeota,2N9GY@224756|Methanomicrobia	224756|Methanomicrobia	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	psmB	-	3.4.25.1	ko:K03433	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
PYH1_k127_7042984_1	247490.KSU1_C0755	1.054e-18	86.0	COG1592@1|root,COG1592@2|Bacteria,2J2TT@203682|Planctomycetes	203682|Planctomycetes	C	Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
PYH1_k127_7042984_0	877455.Metbo_0119	1.789e-134	440.0	COG0019@1|root,arCOG02268@2157|Archaea,2XSY8@28890|Euryarchaeota,23NJI@183925|Methanobacteria	183925|Methanobacteria	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
PYH1_k127_7042984_2	1365176.N186_07630	7.365e-08	56.0	COG1055@1|root,arCOG00238@2157|Archaea,2XQX1@28889|Crenarchaeota	28889|Crenarchaeota	P	Sodium:sulfate symporter transmembrane region	-	-	-	ko:K11106,ko:K14445	-	-	-	-	ko00000,ko02000	2.A.47.1,2.A.47.3.3	-	-	Na_sulph_symp
PYH1_k127_7073852_1	1094980.Mpsy_2224	5.521e-46	176.0	COG1968@1|root,arCOG04761@2157|Archaea,2XTYX@28890|Euryarchaeota	28890|Euryarchaeota	I	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP)	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
PYH1_k127_7073852_2	224325.AF_0187	1.576e-38	147.0	COG2044@1|root,arCOG02066@2157|Archaea,2XWA5@28890|Euryarchaeota	28890|Euryarchaeota	O	PFAM DsrE family protein	-	GO:0008150,GO:0009987,GO:0019725,GO:0042592,GO:0048878,GO:0055082,GO:0065007,GO:0065008	-	ko:K07092	-	-	-	-	ko00000	-	-	-	DrsE,TusA
PYH1_k127_7073852_0	42256.RradSPS_0871	2.558e-63	223.0	COG1478@1|root,COG1478@2|Bacteria,2GMJ8@201174|Actinobacteria,4CQ5F@84995|Rubrobacteria	84995|Rubrobacteria	C	F420-0:Gamma-glutamyl ligase	-	-	6.3.2.31,6.3.2.34	ko:K12234	ko00680,ko01120,map00680,map01120	M00378	R09399,R09400	RC00064,RC00090,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_ligase
PYH1_k127_7138863_2	1365176.N186_06145	9.972e-18	85.0	COG0127@1|root,arCOG04184@2157|Archaea,2XQHP@28889|Crenarchaeota	28889|Crenarchaeota	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	ntpA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
PYH1_k127_7138863_1	195522.BD01_0646	1.738e-49	183.0	COG0533@1|root,arCOG01185@2157|Archaea,2XX5D@28890|Euryarchaeota,2436E@183968|Thermococci	183968|Thermococci	T	serine threonine protein kinase	-	GO:0000408,GO:0002949,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360	2.7.11.1	ko:K08851	-	-	-	-	ko00000,ko01000,ko01001,ko03016	-	-	-	RIO1
PYH1_k127_7138863_0	386456.JQKN01000020_gene1319	8.858e-119	390.0	COG0533@1|root,arCOG01183@2157|Archaea,arCOG01185@2157|Archaea,2XT07@28890|Euryarchaeota,23NPI@183925|Methanobacteria	183925|Methanobacteria	LT	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function	-	-	2.3.1.234,2.7.11.1	ko:K15904	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko01001,ko03016	-	-	-	Peptidase_M22,Pkinase,RIO1
PYH1_k127_7141389_0	935948.KE386494_gene911	1.44e-161	516.0	COG1453@1|root,COG1453@2|Bacteria,1TQ5N@1239|Firmicutes,247SD@186801|Clostridia,42ENG@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM aldo keto reductase	-	-	-	ko:K07079	-	-	-	-	ko00000	-	-	-	Aldo_ket_red,Fer4_17
PYH1_k127_7155547_1	373903.Hore_06160	5.159e-21	96.0	COG1489@1|root,COG1489@2|Bacteria,1V1GZ@1239|Firmicutes,24A0M@186801|Clostridia,3WBSY@53433|Halanaerobiales	186801|Clostridia	S	Sugar fermentation stimulation protein	sfsA	-	-	ko:K06206	-	-	-	-	ko00000	-	-	-	SfsA
PYH1_k127_7155547_2	69319.XP_008555454.1	2.124e-12	77.0	COG0483@1|root,KOG2951@2759|Eukaryota,3A1F3@33154|Opisthokonta,3BQ80@33208|Metazoa,3D6ZR@33213|Bilateria,41ZP1@6656|Arthropoda,3SMQD@50557|Insecta,46JEU@7399|Hymenoptera	33208|Metazoa	G	Inositol monophosphatase family	-	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006020,GO:0006066,GO:0006793,GO:0006796,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008934,GO:0009056,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0019751,GO:0023052,GO:0042578,GO:0043647,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046164,GO:0046174,GO:0046434,GO:0046838,GO:0046855,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0052745,GO:0052834,GO:0065007,GO:0071545,GO:0071704,GO:1901575,GO:1901615,GO:1901616	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
PYH1_k127_7155547_0	673860.AciM339_0825	6.443e-33	134.0	COG2094@1|root,arCOG04295@2157|Archaea,2Y0AE@28890|Euryarchaeota,3F2UP@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Belongs to the DNA glycosylase MPG family	mpg	-	3.2.2.21	ko:K03652	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Pur_DNA_glyco
PYH1_k127_7188846_0	570967.JMLV01000007_gene892	5.084e-80	278.0	COG2515@1|root,COG2515@2|Bacteria,1MVYF@1224|Proteobacteria,2TRCB@28211|Alphaproteobacteria,2JPJQ@204441|Rhodospirillales	204441|Rhodospirillales	E	Pyridoxal-phosphate dependent enzyme	-	-	-	-	-	-	-	-	-	-	-	-	PALP
PYH1_k127_7229709_3	747365.Thena_1364	1.933e-17	83.0	COG1146@1|root,COG1146@2|Bacteria,1UJK8@1239|Firmicutes,25F5P@186801|Clostridia	186801|Clostridia	C	4Fe-4S single cluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_4
PYH1_k127_7229709_0	941824.TCEL_00174	7.378e-48	178.0	COG0424@1|root,COG0424@2|Bacteria,1V6FH@1239|Firmicutes,24JRN@186801|Clostridia,36IU5@31979|Clostridiaceae	186801|Clostridia	D	Maf-like protein	maf	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
PYH1_k127_7229709_1	1194972.MVAC_18930	3.337e-35	141.0	COG0350@1|root,COG0350@2|Bacteria,2IHXW@201174|Actinobacteria,238JK@1762|Mycobacteriaceae	201174|Actinobacteria	L	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated	ogt	GO:0003674,GO:0003824,GO:0003908,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006304,GO:0006307,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0009987,GO:0016020,GO:0016740,GO:0016741,GO:0032259,GO:0033554,GO:0034641,GO:0035510,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051409,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:1901360	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1,Methyltransf_1N
PYH1_k127_7229709_2	330214.NIDE0740	3.437e-35	141.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
PYH1_k127_7255217_1	933262.AXAM01000008_gene1926	0.0001358	49.0	2EB0T@1|root,3351P@2|Bacteria,1NJAF@1224|Proteobacteria,431ZP@68525|delta/epsilon subdivisions,2WW83@28221|Deltaproteobacteria,2MNY6@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_7255217_0	1123248.KB893316_gene4609	6.66e-19	87.0	2EMYX@1|root,33FM2@2|Bacteria,4NY90@976|Bacteroidetes,1IZI6@117747|Sphingobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_7280179_0	269799.Gmet_1138	2.158e-14	83.0	COG3501@1|root,COG3501@2|Bacteria,1R540@1224|Proteobacteria,42Q1X@68525|delta/epsilon subdivisions,2WM75@28221|Deltaproteobacteria,43VDG@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Baseplate assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_7294205_2	255470.cbdbA849	2.587e-46	178.0	COG0493@1|root,COG0852@1|root,COG0493@2|Bacteria,COG0852@2|Bacteria,2G82F@200795|Chloroflexi,34D25@301297|Dehalococcoidia	301297|Dehalococcoidia	C	Respiratory-chain NADH dehydrogenase, 30 Kd subunit	-	-	-	-	-	-	-	-	-	-	-	-	Complex1_30kDa,Fer4_20,Pyr_redox_2
PYH1_k127_7294205_1	255470.cbdbA844	2.295e-72	246.0	COG3260@1|root,COG3260@2|Bacteria,2G8XX@200795|Chloroflexi,34D8I@301297|Dehalococcoidia	301297|Dehalococcoidia	C	NADH ubiquinone oxidoreductase, 20 Kd subunit	echC	-	-	ko:K14088	-	-	-	-	ko00000	-	-	-	Oxidored_q6
PYH1_k127_7294205_0	477974.Daud_1099	4.632e-73	254.0	COG0650@1|root,COG0650@2|Bacteria,1UIUW@1239|Firmicutes,249VU@186801|Clostridia,261JX@186807|Peptococcaceae	186801|Clostridia	C	NADH dehydrogenase	-	-	1.6.5.3	ko:K00337,ko:K14087	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
PYH1_k127_7299763_0	1267534.KB906756_gene225	2.822e-107	367.0	COG1574@1|root,COG1574@2|Bacteria	2|Bacteria	G	metal-dependent hydrolase with the TIM-barrel fold	nfdA	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
PYH1_k127_7299763_1	1122915.AUGY01000118_gene6533	3.371e-102	342.0	COG0715@1|root,COG0715@2|Bacteria,1VRJ0@1239|Firmicutes,4HV8W@91061|Bacilli,26U3V@186822|Paenibacillaceae	91061|Bacilli	P	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_7342302_4	1056495.Calag_0480	6.778e-64	227.0	COG0045@1|root,arCOG01337@2157|Archaea,2XPUW@28889|Crenarchaeota	28889|Crenarchaeota	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
PYH1_k127_7342302_2	272557.APE_1072.1	4.764e-101	336.0	COG0074@1|root,arCOG01339@2157|Archaea,2XPW3@28889|Crenarchaeota	28889|Crenarchaeota	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA,Succ_CoA_lig
PYH1_k127_7342302_5	338966.Ppro_2902	1.456e-22	104.0	COG1051@1|root,COG1051@2|Bacteria,1RJAP@1224|Proteobacteria,42SFP@68525|delta/epsilon subdivisions,2WPBX@28221|Deltaproteobacteria,43SJP@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
PYH1_k127_7342302_3	399549.Msed_2173	2.141e-88	299.0	COG0489@1|root,arCOG00585@2157|Archaea,2XPV2@28889|Crenarchaeota	28889|Crenarchaeota	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	-	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	ParA
PYH1_k127_7342302_1	436308.Nmar_1322	3.173e-130	436.0	COG3569@1|root,arCOG08649@2157|Archaea,41SDH@651137|Thaumarchaeota	651137|Thaumarchaeota	L	DNA Topoisomerase I (eukaryota)	-	-	5.99.1.2	ko:K03163	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	Topo_C_assoc,Topoisom_I,Topoisom_I_N
PYH1_k127_7342302_6	96561.Dole_1513	1.512e-09	66.0	COG3118@1|root,COG3118@2|Bacteria,1MZBB@1224|Proteobacteria,42TPU@68525|delta/epsilon subdivisions,2WQ1M@28221|Deltaproteobacteria,2MKJV@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Belongs to the thioredoxin family	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
PYH1_k127_7342302_0	693661.Arcve_2079	4.912e-177	569.0	COG2217@1|root,arCOG02763@1|root,arCOG02764@1|root,arCOG01576@2157|Archaea,arCOG02763@2157|Archaea,arCOG02764@2157|Archaea,2XT3T@28890|Euryarchaeota,245W8@183980|Archaeoglobi	183980|Archaeoglobi	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0042802,GO:0044464,GO:0071944	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
PYH1_k127_7352242_3	330779.Saci_1513	9.081e-40	152.0	COG0024@1|root,arCOG01001@2157|Archaea,2XPVJ@28889|Crenarchaeota	28889|Crenarchaeota	E	Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val)	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
PYH1_k127_7352242_7	1501230.ET33_00130	4.342e-17	87.0	COG0589@1|root,COG0589@2|Bacteria,1VEJR@1239|Firmicutes,4HNHG@91061|Bacilli,26XFT@186822|Paenibacillaceae	91061|Bacilli	T	Belongs to the universal stress protein A family	uspA	-	-	-	-	-	-	-	-	-	-	-	Usp
PYH1_k127_7352242_5	342949.PNA2_0563	2.895e-27	119.0	COG0491@1|root,arCOG00504@2157|Archaea,2XWX3@28890|Euryarchaeota,243YZ@183968|Thermococci	183968|Thermococci	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
PYH1_k127_7352242_1	584708.Apau_0298	3.083e-75	262.0	COG0491@1|root,COG0491@2|Bacteria,3TBY6@508458|Synergistetes	508458|Synergistetes	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
PYH1_k127_7352242_0	374847.Kcr_0159	1.459e-90	313.0	COG0665@1|root,arCOG00755@2157|Archaea	2157|Archaea	E	COG0665 Glycine D-amino acid oxidases (deaminating)	-	-	-	-	-	-	-	-	-	-	-	-	DAO
PYH1_k127_7352242_4	479434.Sthe_0424	1.924e-32	138.0	COG0010@1|root,COG0010@2|Bacteria,2G8DY@200795|Chloroflexi	200795|Chloroflexi	E	Belongs to the arginase family	-	-	3.5.3.1	ko:K01476	ko00220,ko00330,ko01100,ko01110,ko01130,ko01230,ko05146,map00220,map00330,map01100,map01110,map01130,map01230,map05146	M00029,M00134	R00551	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
PYH1_k127_7352242_2	1265502.KB905930_gene1484	3.376e-55	198.0	COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,2VQ6F@28216|Betaproteobacteria,4ADGN@80864|Comamonadaceae	28216|Betaproteobacteria	M	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	ppiA	-	5.2.1.8	ko:K03767,ko:K03768	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Pro_isomerase
PYH1_k127_7352242_6	439481.Aboo_0797	6.819e-20	96.0	COG1599@1|root,arCOG01510@2157|Archaea,2Y72Y@28890|Euryarchaeota,3F3AT@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins	-	-	-	ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko03000,ko03032,ko03400	-	-	-	-
PYH1_k127_737281_0	1459636.NTE_02721	4.387e-94	320.0	COG0252@1|root,arCOG01924@2157|Archaea,41SD7@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate	gatD	-	6.3.5.7	ko:K09482	ko00970,ko01100,map00970,map01100	-	R03905	RC00010	ko00000,ko00001,ko01000	-	-	-	Asparaginase
PYH1_k127_737281_1	1034347.CAHJ01000048_gene200	3.243e-08	59.0	29S0I@1|root,30D4V@2|Bacteria,1UAUQ@1239|Firmicutes,4IM7I@91061|Bacilli,1ZJEH@1386|Bacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_7382966_0	903814.ELI_0288	4.605e-33	137.0	COG2006@1|root,COG2006@2|Bacteria,1TRYQ@1239|Firmicutes,24966@186801|Clostridia,25X3Z@186806|Eubacteriaceae	186801|Clostridia	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
PYH1_k127_7382966_2	903814.ELI_2336	1.851e-06	52.0	COG1765@1|root,COG1765@2|Bacteria,1UKFU@1239|Firmicutes,25FW0@186801|Clostridia,25WI7@186806|Eubacteriaceae	186801|Clostridia	O	Protein of unknown function (DUF3795)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3795
PYH1_k127_7382966_1	529709.PYCH_01940	6.1e-08	58.0	arCOG04079@1|root,arCOG04079@2157|Archaea,2Y184@28890|Euryarchaeota,2448K@183968|Thermococci	183968|Thermococci	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_7387014_0	335541.Swol_1837	5.895e-06	55.0	COG1848@1|root,COG1848@2|Bacteria,1U5UN@1239|Firmicutes,25P95@186801|Clostridia,42KUD@68298|Syntrophomonadaceae	186801|Clostridia	S	Large family of predicted nucleotide-binding domains	-	-	-	-	-	-	-	-	-	-	-	-	PIN
PYH1_k127_7387014_1	1123371.ATXH01000004_gene1800	7.034e-06	51.0	2DSSK@1|root,33H9W@2|Bacteria	2|Bacteria	K	SpoVT / AbrB like domain	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin
PYH1_k127_7400333_3	399550.Smar_0666	2.144e-05	51.0	COG1977@1|root,arCOG00536@2157|Archaea	2157|Archaea	H	Molybdopterin converting factor, small subunit	-	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
PYH1_k127_7400333_0	604354.TSIB_1133	2.388e-210	670.0	COG2414@1|root,arCOG00709@2157|Archaea,2Y2PK@28890|Euryarchaeota,242X9@183968|Thermococci	183968|Thermococci	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
PYH1_k127_7400333_1	1365176.N186_08495	1.083e-54	196.0	COG1142@1|root,arCOG01502@2157|Archaea,2XR9N@28889|Crenarchaeota	28889|Crenarchaeota	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_3,Fer4_4,Fer4_6,Fer4_9
PYH1_k127_7400333_2	469617.FUAG_01054	6.655e-24	110.0	COG0471@1|root,COG0471@2|Bacteria,37B7R@32066|Fusobacteria	32066|Fusobacteria	P	Sodium:sulfate symporter transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	Na_sulph_symp
PYH1_k127_7465918_4	485917.Phep_2598	7.243e-06	55.0	COG2271@1|root,COG2271@2|Bacteria,4NFKX@976|Bacteroidetes,1IQUV@117747|Sphingobacteriia	976|Bacteroidetes	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
PYH1_k127_7465918_1	1211819.CALK01000036_gene30	4.719e-65	244.0	COG3653@1|root,COG3653@2|Bacteria,1TSGD@1239|Firmicutes	1239|Firmicutes	Q	PFAM D-aminoacylase	dan	-	3.5.1.81	ko:K06015	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
PYH1_k127_7465918_0	1131730.BAVI_25439	7.564e-94	324.0	COG0044@1|root,COG0044@2|Bacteria,1TPQM@1239|Firmicutes,4HA90@91061|Bacilli,1ZQ9N@1386|Bacillus	91061|Bacilli	F	Amidohydrolase family	allB	-	3.5.2.3,3.5.2.5	ko:K01465,ko:K01466	ko00230,ko00240,ko01100,ko01120,map00230,map00240,map01100,map01120	M00051,M00546	R01993,R02425	RC00632,RC00680	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
PYH1_k127_7465918_2	387631.Asulf_01213	2.635e-25	109.0	COG0727@1|root,arCOG02579@2157|Archaea,2Y1J3@28890|Euryarchaeota	28890|Euryarchaeota	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
PYH1_k127_7465918_3	1220534.B655_0196	3.793e-25	111.0	COG1180@1|root,arCOG00952@2157|Archaea,2XYH1@28890|Euryarchaeota,23P3N@183925|Methanobacteria	183925|Methanobacteria	C	4Fe-4S single cluster domain	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
PYH1_k127_7514048_1	316058.RPB_4421	3.514e-06	54.0	COG0006@1|root,COG0006@2|Bacteria,1MVJK@1224|Proteobacteria,2TVVP@28211|Alphaproteobacteria,3JSAA@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Creatinase/Prolidase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Creatinase_N,Peptidase_M24
PYH1_k127_7514048_0	935840.JAEQ01000019_gene2114	2.493e-61	225.0	COG2355@1|root,COG2355@2|Bacteria,1MWEW@1224|Proteobacteria,2TR5C@28211|Alphaproteobacteria,43KX1@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Membrane dipeptidase (Peptidase family M19)	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
PYH1_k127_7514048_2	1121365.AQXB01000007_gene277	7.605e-05	53.0	COG0477@1|root,COG2814@2|Bacteria,2H32P@201174|Actinobacteria,22JY5@1653|Corynebacteriaceae	201174|Actinobacteria	EGP	the major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
PYH1_k127_7541871_1	1365176.N186_04950	2.571e-28	117.0	COG0644@1|root,arCOG00570@2157|Archaea,2XPWV@28889|Crenarchaeota	28889|Crenarchaeota	C	TIGRFAM geranylgeranyl reductase	-	-	1.3.1.101,1.3.7.11	ko:K17830	ko00564,map00564	-	R10325,R10326,R10331	RC03134	ko00000,ko00001,ko01000	-	-	-	DAO,FAD_binding_2,FAD_binding_3,FAD_oxidored,Trp_halogenase
PYH1_k127_7541871_0	224325.AF_1255	5.81e-78	270.0	COG0448@1|root,arCOG00912@2157|Archaea,2XTI4@28890|Euryarchaeota,24625@183980|Archaeoglobi	183980|Archaeoglobi	E	Belongs to the ATCase OTCase family	-	-	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
PYH1_k127_7546754_0	765177.Desmu_0498	3.422e-26	126.0	COG1409@1|root,arCOG01144@2157|Archaea,2XQ01@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM metallophosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
PYH1_k127_7550799_1	1502851.FG93_04867	1.279e-71	253.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TQKK@28211|Alphaproteobacteria,3JX3Y@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
PYH1_k127_7550799_2	1502851.FG93_04868	1.4e-58	214.0	COG1173@1|root,COG1173@2|Bacteria,1MVHY@1224|Proteobacteria,2TQVQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EP	ABC-type dipeptide oligopeptide nickel transport systems, permease components	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1,OppC_N
PYH1_k127_7550799_0	292459.STH2824	9.704e-109	361.0	COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,247NN@186801|Clostridia	186801|Clostridia	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031,ko:K02032,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
PYH1_k127_7569563_2	399550.Smar_1310	2.145e-59	215.0	COG0171@1|root,arCOG00069@2157|Archaea,2XQ3J@28889|Crenarchaeota	28889|Crenarchaeota	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source	nadE	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.1.5	ko:K01916	ko00760,ko01100,map00760,map01100	M00115	R00189	RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	NAD_synthase
PYH1_k127_7569563_3	999630.TUZN_1799	4.884e-06	52.0	COG4888@1|root,arCOG04136@2157|Archaea,2XR0Q@28889|Crenarchaeota	28889|Crenarchaeota	J	PFAM Transcription elongation factor Elf1 like	-	-	-	-	-	-	-	-	-	-	-	-	Elf1
PYH1_k127_7569563_1	868131.MSWAN_0376	2.094e-71	249.0	COG1646@1|root,arCOG01085@2157|Archaea,2XTEC@28890|Euryarchaeota,23NWS@183925|Methanobacteria	183925|Methanobacteria	H	Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids	-	-	2.5.1.41	ko:K17104	ko00564,map00564	-	R04158	RC01091	ko00000,ko00001,ko01000	-	-	-	PcrB
PYH1_k127_7569563_0	644281.MFS40622_0645	6.041e-126	418.0	COG1933@1|root,arCOG04447@2157|Archaea,2XU5S@28890|Euryarchaeota,23Q0E@183939|Methanococci	183939|Methanococci	L	Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase	polC	-	2.7.7.7	ko:K02322	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	M00264	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	Intein_splicing,LAGLIDADG_3,PolC_DP2
PYH1_k127_7579761_0	1396.DJ87_5184	4.317e-103	360.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1TR2N@1239|Firmicutes,4H9RR@91061|Bacilli,1ZB2Q@1386|Bacillus	91061|Bacilli	EU	peptidase	yuxL	-	3.4.19.1	ko:K01303	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,Peptidase_S9
PYH1_k127_7614502_1	768679.TTX_2075	1.771e-06	49.0	COG1136@1|root,arCOG00922@2157|Archaea,2XQ2I@28889|Crenarchaeota	28889|Crenarchaeota	E	PFAM ABC transporter related	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
PYH1_k127_7614502_0	415426.Hbut_0902	5.509e-27	121.0	COG0577@1|root,arCOG02312@2157|Archaea,2XQ0N@28889|Crenarchaeota	28889|Crenarchaeota	V	ABC-type transport system involved in lipoprotein release permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
PYH1_k127_76565_0	485913.Krac_10289	1.403e-31	137.0	COG2933@1|root,COG2933@2|Bacteria,2G6K6@200795|Chloroflexi	200795|Chloroflexi	J	FtsJ-like methyltransferase	-	-	2.1.1.186	ko:K06968	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ,THUMP
PYH1_k127_76565_1	1122164.JHWF01000023_gene427	3.048e-13	77.0	COG2267@1|root,COG2267@2|Bacteria,1NTH9@1224|Proteobacteria,1RYBB@1236|Gammaproteobacteria,1JCZC@118969|Legionellales	118969|Legionellales	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
PYH1_k127_7657639_1	765952.PUV_27630	3.245e-05	53.0	COG0847@1|root,COG0847@2|Bacteria,2JFW8@204428|Chlamydiae	204428|Chlamydiae	L	DNA polymerase III, epsilon	dnaQ_2	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	QSregVF_b,RNase_T
PYH1_k127_7657639_0	1304885.AUEY01000145_gene1078	1.996e-13	74.0	2DY37@1|root,347XD@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_767978_1	1343739.PAP_09615	1.549e-63	224.0	COG1709@1|root,arCOG04060@2157|Archaea,2XT58@28890|Euryarchaeota,243MS@183968|Thermococci	183968|Thermococci	K	Helix-turn-helix domain	-	-	-	ko:K07731	-	-	-	-	ko00000,ko03000	-	-	-	HTH_19,HTH_3
PYH1_k127_767978_0	1184251.TCELL_1237	2.986e-112	371.0	COG1013@1|root,arCOG01601@2157|Archaea,2XPQR@28889|Crenarchaeota	28889|Crenarchaeota	C	PFAM Thiamine pyrophosphate	-	-	1.2.7.1	ko:K00170	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
PYH1_k127_767978_2	1304880.JAGB01000004_gene1407	7.763e-62	220.0	COG0674@1|root,COG0674@2|Bacteria,1VS48@1239|Firmicutes,25E5U@186801|Clostridia	186801|Clostridia	C	pyruvate flavodoxin ferredoxin oxidoreductase	porA	-	1.2.7.1	ko:K00169	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
PYH1_k127_7789686_0	243231.GSU2100	0.0	1212.0	COG0376@1|root,COG0376@2|Bacteria,1MUBF@1224|Proteobacteria,42MZ4@68525|delta/epsilon subdivisions,2WJPB@28221|Deltaproteobacteria,43T5J@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity	katG	GO:0000302,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016684,GO:0016999,GO:0017001,GO:0017144,GO:0020037,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042542,GO:0042737,GO:0042743,GO:0042744,GO:0044237,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0046906,GO:0048037,GO:0050896,GO:0051186,GO:0051187,GO:0051716,GO:0055114,GO:0070301,GO:0070887,GO:0071236,GO:0072593,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901363,GO:1901700,GO:1901701,GO:1990748	1.11.1.21	ko:K03782	ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110	-	R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906	RC00034,RC00213,RC00767,RC02141	ko00000,ko00001,ko01000	-	-	-	peroxidase
PYH1_k127_7789686_1	909663.KI867151_gene3063	9.51e-162	521.0	COG0415@1|root,COG0415@2|Bacteria,1RG4D@1224|Proteobacteria,42NWP@68525|delta/epsilon subdivisions,2WJUA@28221|Deltaproteobacteria,2MQYG@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	DNA photolyase	phr	-	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase,FAD_binding_7
PYH1_k127_7789686_2	368407.Memar_2274	1.971e-90	308.0	COG1683@1|root,arCOG04848@2157|Archaea,2XV91@28890|Euryarchaeota,2NANV@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF1722)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1722,DUF523
PYH1_k127_7800364_2	479434.Sthe_2693	2.178e-24	109.0	COG0624@1|root,COG0624@2|Bacteria	2|Bacteria	E	succinyl-diaminopimelate desuccinylase activity	-	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
PYH1_k127_7800364_1	608506.COB47_0274	2.584e-32	128.0	COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1TPA1@1239|Firmicutes,248AU@186801|Clostridia,42EPT@68295|Thermoanaerobacterales	186801|Clostridia	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
PYH1_k127_7800364_0	990073.ATHU01000003_gene1843	7.975e-61	218.0	COG0846@1|root,COG0846@2|Bacteria,1MUK1@1224|Proteobacteria,42R4A@68525|delta/epsilon subdivisions,2YTQN@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	K	Sir2 family	-	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
PYH1_k127_7847777_2	1384054.N790_09180	2.542e-11	65.0	COG1765@1|root,COG1765@2|Bacteria,1N1RR@1224|Proteobacteria,1S3KI@1236|Gammaproteobacteria,1X77I@135614|Xanthomonadales	135614|Xanthomonadales	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
PYH1_k127_7847777_1	573370.DMR_07650	1.036e-24	109.0	COG3467@1|root,COG3467@2|Bacteria,1N4RH@1224|Proteobacteria,42TKQ@68525|delta/epsilon subdivisions,2WQ06@28221|Deltaproteobacteria,2MBAF@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM Pyridoxamine 5'-phosphate oxidase-related	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Pyridox_ox_2
PYH1_k127_7847777_0	1131266.ARWQ01000011_gene121	2.44e-146	471.0	COG1163@1|root,arCOG00358@2157|Archaea,41SAD@651137|Thaumarchaeota	651137|Thaumarchaeota	S	small GTP-binding protein	-	-	-	ko:K06944	-	-	-	-	ko00000	-	-	-	MMR_HSR1,MMR_HSR1_Xtn,TGS
PYH1_k127_7851608_3	868131.MSWAN_0193	1.005e-18	89.0	COG3371@1|root,arCOG02008@2157|Archaea,2Y0X8@28890|Euryarchaeota	28890|Euryarchaeota	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF998
PYH1_k127_7851608_0	1114856.C496_19500	1.779e-173	550.0	COG1834@1|root,arCOG03109@2157|Archaea,2Y14I@28890|Euryarchaeota,23YTN@183963|Halobacteria	183963|Halobacteria	E	Amidinotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Amidinotransf
PYH1_k127_7851608_1	1031288.AXAA01000002_gene1422	1.143e-85	296.0	COG1453@1|root,COG1453@2|Bacteria,1TSTA@1239|Firmicutes,249IP@186801|Clostridia,36FVM@31979|Clostridiaceae	186801|Clostridia	S	aldo keto reductase	-	-	-	ko:K07079	-	-	-	-	ko00000	-	-	-	Aldo_ket_red,Fer4_17
PYH1_k127_7851608_2	1056495.Calag_0675	1.702e-59	222.0	COG0624@1|root,arCOG01107@2157|Archaea,2XPWH@28889|Crenarchaeota	28889|Crenarchaeota	E	TIGRFAM acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase	dapE	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
PYH1_k127_7856642_1	1343739.PAP_05485	5.984e-26	120.0	COG4945@1|root,arCOG01310@2157|Archaea,arCOG03771@2157|Archaea,2XSTV@28890|Euryarchaeota,245KU@183968|Thermococci	183968|Thermococci	G	C-terminal binding-module, SLH-like, of glucodextranase	-	-	-	-	-	-	-	-	-	-	-	-	Glucodextran_C,PEGA
PYH1_k127_7856642_0	1198449.ACAM_1086	4.221e-115	390.0	COG1840@1|root,arCOG00221@2157|Archaea,2XPPY@28889|Crenarchaeota	28889|Crenarchaeota	P	PFAM extracellular solute-binding protein family 1	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_1,SBP_bac_6,SBP_bac_8
PYH1_k127_7865807_1	1449063.JMLS01000001_gene4452	1.876e-114	379.0	COG0119@1|root,COG0119@2|Bacteria,1TP4Y@1239|Firmicutes	1239|Firmicutes	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	-	GO:0003674,GO:0003824,GO:0016740,GO:0016746,GO:0036440,GO:0046912,GO:0050450	-	-	-	-	-	-	-	-	-	iHN637.CLJU_RS03250	HMGL-like
PYH1_k127_7865807_0	720554.Clocl_3832	8.184e-177	563.0	COG1048@1|root,COG1048@2|Bacteria,1VTMM@1239|Firmicutes,25HJM@186801|Clostridia,3WG9R@541000|Ruminococcaceae	186801|Clostridia	C	aconitate hydratase	acnA	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
PYH1_k127_7867385_0	1343739.PAP_06405	8.938e-125	409.0	COG0015@1|root,arCOG01747@2157|Archaea,2XUQ5@28890|Euryarchaeota,24385@183968|Thermococci	183968|Thermococci	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	purB	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
PYH1_k127_7867385_1	290317.Cpha266_2156	3.064e-05	52.0	COG2606@1|root,COG2606@2|Bacteria,1FF1M@1090|Chlorobi	1090|Chlorobi	S	PFAM YbaK prolyl-tRNA synthetase associated region	-	-	-	ko:K19055	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_edit
PYH1_k127_7885942_1	1121877.JQKF01000044_gene1227	4.321e-13	79.0	COG0477@1|root,COG2814@2|Bacteria,2HGMG@201174|Actinobacteria,4CNKA@84992|Acidimicrobiia	84992|Acidimicrobiia	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
PYH1_k127_7885942_0	1265505.ATUG01000002_gene1107	3.811e-34	139.0	COG1143@1|root,COG1143@2|Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_6
PYH1_k127_788787_5	398512.JQKC01000002_gene1755	6.771e-15	77.0	COG0152@1|root,COG0152@2|Bacteria,1TP11@1239|Firmicutes,2483I@186801|Clostridia,3WRT3@541000|Ruminococcaceae	186801|Clostridia	F	SAICAR synthetase	purC	-	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
PYH1_k127_788787_1	523850.TON_1168	1.618e-32	134.0	COG0558@1|root,arCOG00670@2157|Archaea,2XWJ0@28890|Euryarchaeota,245EJ@183968|Thermococci	183968|Thermococci	I	CDP-alcohol phosphatidyltransferase	-	-	2.7.8.39	ko:K17884	-	-	R10464	RC00002,RC00078	ko00000,ko01000	-	-	-	CDP-OH_P_transf
PYH1_k127_788787_3	1459636.NTE_01923	7.042e-25	107.0	COG4830@1|root,arCOG04305@2157|Archaea,41SNM@651137|Thaumarchaeota	651137|Thaumarchaeota	J	ribosomal protein	-	-	-	ko:K02976	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S26e
PYH1_k127_788787_6	1121342.AUCO01000005_gene200	3.654e-12	74.0	COG2755@1|root,COG2755@2|Bacteria,1VDE2@1239|Firmicutes,25BKU@186801|Clostridia,36KDK@31979|Clostridiaceae	186801|Clostridia	E	GDSL-like Lipase/Acylhydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
PYH1_k127_788787_2	368408.Tpen_0032	7.3e-26	111.0	COG4900@1|root,arCOG04217@2157|Archaea,2XQUZ@28889|Crenarchaeota	28889|Crenarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_788787_4	1459636.NTE_01618	1.755e-19	93.0	COG1310@1|root,arCOG01139@2157|Archaea,41SQ7@651137|Thaumarchaeota	651137|Thaumarchaeota	S	metal-dependent protease of the PAD1 JAB1 superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Prok-JAB
PYH1_k127_788787_0	1365176.N186_02635	2.973e-163	531.0	COG0525@1|root,arCOG00808@2157|Archaea,2XPW9@28889|Crenarchaeota	28889|Crenarchaeota	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
PYH1_k127_79061_0	694429.Pyrfu_1607	1.476e-74	261.0	COG1032@1|root,arCOG01356@2157|Archaea,2XPY0@28889|Crenarchaeota	28889|Crenarchaeota	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
PYH1_k127_79061_3	1163730.FFONT_0202	1.383e-05	49.0	COG1996@1|root,arCOG04341@2157|Archaea	2157|Archaea	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoP	-	2.7.7.6	ko:K03059	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	DNA_RNApol_7kD
PYH1_k127_79061_1	768672.Desfe_1471	1.626e-17	89.0	COG2012@1|root,arCOG04258@2157|Archaea,2XR25@28889|Crenarchaeota	28889|Crenarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoH	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03053	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb5_C
PYH1_k127_79061_2	1365176.N186_05125	1.31e-12	75.0	arCOG05463@1|root,arCOG05463@2157|Archaea,2XSF3@28889|Crenarchaeota	28889|Crenarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_7929223_0	1220534.B655_0353	8.672e-89	306.0	COG0674@1|root,arCOG01608@2157|Archaea,2XTB0@28890|Euryarchaeota,23NRM@183925|Methanobacteria	183925|Methanobacteria	C	ferredoxin oxidoreductase	porA	-	1.2.7.1	ko:K00169	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
PYH1_k127_7929223_1	565033.GACE_2153	1.357e-56	207.0	COG1144@1|root,arCOG01604@2157|Archaea	2157|Archaea	C	TIGRFAM 2-oxoacid acceptor oxidoreductase, delta subunit, pyruvate 2-ketoisovalerate	-	-	1.2.7.1	ko:K00171,ko:K00172	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,POR
PYH1_k127_7929223_2	264732.Moth_0405	9.165e-27	122.0	COG4986@1|root,COG4986@2|Bacteria,1TRRR@1239|Firmicutes,248X4@186801|Clostridia,42HSS@68295|Thermoanaerobacterales	186801|Clostridia	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
PYH1_k127_7929696_2	161934.XP_010682545.1	2.197e-05	50.0	KOG2501@1|root,KOG2501@2759|Eukaryota,37JND@33090|Viridiplantae,3GDD8@35493|Streptophyta	35493|Streptophyta	O	Nucleoredoxin	-	GO:0000003,GO:0000902,GO:0000904,GO:0001558,GO:0003006,GO:0003674,GO:0003824,GO:0004791,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006935,GO:0008150,GO:0008152,GO:0009605,GO:0009636,GO:0009653,GO:0009826,GO:0009856,GO:0009860,GO:0009932,GO:0009987,GO:0010035,GO:0010038,GO:0010183,GO:0010769,GO:0015036,GO:0016043,GO:0016049,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0022414,GO:0022603,GO:0022604,GO:0030154,GO:0032501,GO:0032502,GO:0032989,GO:0040007,GO:0040008,GO:0040011,GO:0042221,GO:0042330,GO:0043900,GO:0044424,GO:0044444,GO:0044464,GO:0044706,GO:0045595,GO:0046686,GO:0048468,GO:0048588,GO:0048589,GO:0048638,GO:0048856,GO:0048868,GO:0048869,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0050918,GO:0051128,GO:0051239,GO:0051510,GO:0051704,GO:0051716,GO:0055114,GO:0060284,GO:0060560,GO:0065007,GO:0070887,GO:0071840,GO:0080092,GO:0097237,GO:0098754,GO:0098869,GO:1990748,GO:2000241	1.8.1.8	ko:K17609	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	C1_2,Thioredoxin_8
PYH1_k127_7929696_0	1459636.NTE_01420	1.584e-135	441.0	COG0180@1|root,arCOG01887@2157|Archaea,41SDK@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the class-I aminoacyl-tRNA synthetase family	-	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
PYH1_k127_7929696_1	700598.Niako_5491	3.442e-10	63.0	COG2317@1|root,COG2317@2|Bacteria,4NK5Q@976|Bacteroidetes,1IVUK@117747|Sphingobacteriia	976|Bacteroidetes	E	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues	-	-	3.4.17.19	ko:K01299	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M32
PYH1_k127_7954181_0	523845.AQXV01000031_gene1139	3.182e-79	274.0	COG0087@1|root,arCOG04070@2157|Archaea,2XT9B@28890|Euryarchaeota,23QD1@183939|Methanococci	183939|Methanococci	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rpl3	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
PYH1_k127_7954181_2	877455.Metbo_0775	9.875e-72	250.0	COG0469@1|root,arCOG04071@2157|Archaea,2XTXX@28890|Euryarchaeota,23NJ7@183925|Methanobacteria	183925|Methanobacteria	J	50S ribosomal protein L4	rpl4	-	-	ko:K02930	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
PYH1_k127_7954181_4	573064.Mefer_0738	1.437e-24	105.0	COG0089@1|root,arCOG04072@2157|Archaea,2XYPG@28890|Euryarchaeota,23R46@183939|Methanococci	183939|Methanococci	J	Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome	rpl23	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
PYH1_k127_7954181_1	374847.Kcr_1490	1.947e-76	263.0	COG0090@1|root,arCOG04067@2157|Archaea	2157|Archaea	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rpl2	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
PYH1_k127_7954181_3	69014.TK1538	7.706e-42	157.0	COG0185@1|root,arCOG04099@2157|Archaea,2XWI9@28890|Euryarchaeota,24405@183968|Thermococci	183968|Thermococci	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rps19p	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
PYH1_k127_7959097_0	379066.GAU_3632	1.145e-84	293.0	COG1680@1|root,COG1680@2|Bacteria	2|Bacteria	V	peptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
PYH1_k127_7959097_3	572546.Arcpr_1303	5.258e-25	109.0	COG0517@1|root,arCOG00606@2157|Archaea,2XX11@28890|Euryarchaeota,24692@183980|Archaeoglobi	183980|Archaeoglobi	S	signal transduction protein with CBS domains	-	-	-	-	-	-	-	-	-	-	-	-	CBS
PYH1_k127_7959097_2	1196322.A370_00374	3.847e-41	158.0	COG1853@1|root,COG1853@2|Bacteria,1TSTQ@1239|Firmicutes,24FYK@186801|Clostridia,36EHC@31979|Clostridiaceae	186801|Clostridia	S	Flavin reductase like domain	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
PYH1_k127_7959097_1	523850.TON_1888	7.354e-67	239.0	COG1373@1|root,arCOG03167@2157|Archaea,2XW1E@28890|Euryarchaeota,243BI@183968|Thermococci	183968|Thermococci	S	Domain of unknown function (DUF4143)	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
PYH1_k127_7974331_1	880073.Calab_3044	7.883e-56	201.0	COG1941@1|root,COG1941@2|Bacteria,2NQP6@2323|unclassified Bacteria	2|Bacteria	C	NADH ubiquinone oxidoreductase, 20 Kd subunit	-	-	1.8.98.5	ko:K14128	ko00680,map00680	-	R00019,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	Fe_hyd_lg_C,Fer4,FlpD,Oxidored_q6
PYH1_k127_7974331_0	1449126.JQKL01000002_gene1552	2.114e-143	462.0	COG3259@1|root,COG3259@2|Bacteria,1UZNV@1239|Firmicutes,24F0H@186801|Clostridia	186801|Clostridia	C	PFAM Nickel-dependent hydrogenase, large subunit	-	-	1.8.98.5	ko:K14126	ko00680,map00680	-	R00019,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
PYH1_k127_797728_1	1042877.GQS_10045	1.302e-33	133.0	COG0258@1|root,arCOG04050@2157|Archaea,2XTJD@28890|Euryarchaeota,242ZU@183968|Thermococci	183968|Thermococci	L	Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into	fen	-	-	ko:K04799	ko03030,ko03410,ko03450,map03030,map03410,map03450	-	-	-	ko00000,ko00001,ko01000,ko03032,ko03400,ko04147	-	-	-	XPG_I,XPG_N
PYH1_k127_797728_0	272557.APE_2474.1	3.448e-286	895.0	COG0464@1|root,arCOG01308@2157|Archaea,2XPPI@28889|Crenarchaeota	28889|Crenarchaeota	O	Cell division protein 48 (CDC48), domain 2	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N,Vps4_C
PYH1_k127_7982251_0	1410626.JHXB01000003_gene1155	3.379e-43	175.0	COG1053@1|root,COG1053@2|Bacteria,1TRE8@1239|Firmicutes,247TH@186801|Clostridia	186801|Clostridia	C	PFAM fumarate reductase succinate dehydrogenase flavoprotein domain protein	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_2,Succ_DH_flav_C
PYH1_k127_7982251_1	526218.Sterm_3521	2.393e-15	78.0	COG1146@1|root,COG1146@2|Bacteria	2|Bacteria	C	4 iron, 4 sulfur cluster binding	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_4
PYH1_k127_8004122_0	382464.ABSI01000021_gene453	5.666e-70	248.0	COG0111@1|root,COG0111@2|Bacteria	2|Bacteria	EH	4-phosphoerythronate dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh,2-Hacid_dh_C
PYH1_k127_8004122_1	536227.CcarbDRAFT_4015	1.257e-50	190.0	COG2768@1|root,COG2768@2|Bacteria,1UINS@1239|Firmicutes,25EPC@186801|Clostridia,36V16@31979|Clostridiaceae	186801|Clostridia	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
PYH1_k127_8004122_3	1380394.JADL01000011_gene3924	4.12e-38	153.0	COG3836@1|root,COG3836@2|Bacteria,1QY50@1224|Proteobacteria,2U2PU@28211|Alphaproteobacteria,2JVW5@204441|Rhodospirillales	204441|Rhodospirillales	G	HpcH/HpaI aldolase/citrate lyase family	-	-	-	-	-	-	-	-	-	-	-	-	HpcH_HpaI
PYH1_k127_8004122_2	994573.T472_0218755	9.097e-42	159.0	28PJ3@1|root,2ZC8W@2|Bacteria,1V220@1239|Firmicutes,24IPD@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_8018236_1	247490.KSU1_D0522	3.169e-11	69.0	COG0215@1|root,COG0215@2|Bacteria,2IX9C@203682|Planctomycetes	203682|Planctomycetes	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e,tRNA-synt_1g
PYH1_k127_8018236_0	469371.Tbis_2888	1.772e-52	197.0	COG0491@1|root,COG0491@2|Bacteria,2GMDD@201174|Actinobacteria,4DX45@85010|Pseudonocardiales	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
PYH1_k127_8043572_3	593750.Metfor_0955	1.038e-08	62.0	COG2043@1|root,arCOG02289@2157|Archaea,2XXJQ@28890|Euryarchaeota,2N9KZ@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterised ArCR, COG2043	-	-	-	-	-	-	-	-	-	-	-	-	DUF169
PYH1_k127_8043572_1	1279017.AQYJ01000024_gene1017	3.139e-18	96.0	COG3608@1|root,COG3608@2|Bacteria,1MUAA@1224|Proteobacteria,1RNQQ@1236|Gammaproteobacteria,464NX@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Succinylglutamate desuccinylase / Aspartoacylase family	-	-	-	ko:K06987	-	-	-	-	ko00000	-	-	-	AstE_AspA
PYH1_k127_8043572_0	304371.MCP_0375	5.191e-43	165.0	COG0528@1|root,arCOG00858@2157|Archaea,2XT3U@28890|Euryarchaeota,2N9K9@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	iAF692.Mbar_A0788	AA_kinase
PYH1_k127_8043572_2	1042156.CXIVA_21310	7.85e-14	78.0	COG1433@1|root,COG1433@2|Bacteria,1V7KS@1239|Firmicutes,24J98@186801|Clostridia,36K8I@31979|Clostridiaceae	186801|Clostridia	S	TIGRFAM C_GCAxxG_C_C family	-	-	-	-	-	-	-	-	-	-	-	-	C_GCAxxG_C_C
PYH1_k127_8053859_0	309801.trd_0269	1.095e-57	211.0	COG1363@1|root,COG1363@2|Bacteria,2GB54@200795|Chloroflexi,27YYZ@189775|Thermomicrobia	189775|Thermomicrobia	E	M42 glutamyl aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M42
PYH1_k127_8053859_1	1540257.JQMW01000009_gene2809	1.137e-52	203.0	COG2234@1|root,COG2234@2|Bacteria,1UFM1@1239|Firmicutes	1239|Firmicutes	S	Aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
PYH1_k127_8053859_2	1284775.HMPREF1640_12560	4.335e-14	72.0	COG0458@1|root,COG0458@2|Bacteria,4NEQ0@976|Bacteroidetes,2FMKD@200643|Bacteroidia	976|Bacteroidetes	EF	Carbamoyl-phosphate synthase (glutamine-hydrolyzing)	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
PYH1_k127_8114470_2	694429.Pyrfu_0990	1.899e-52	195.0	COG0244@1|root,arCOG04288@2157|Archaea,2XPMI@28889|Crenarchaeota	28889|Crenarchaeota	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rpl10	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
PYH1_k127_8114470_1	693661.Arcve_0942	2.709e-54	198.0	COG0081@1|root,arCOG04289@2157|Archaea,2XTJF@28890|Euryarchaeota,245YX@183980|Archaeoglobi	183980|Archaeoglobi	J	Binds directly to 23S rRNA. Probably involved in E site tRNA release	rpl1	-	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
PYH1_k127_8114470_3	523845.AQXV01000054_gene1609	3.962e-47	175.0	COG0080@1|root,arCOG04372@2157|Archaea,2XTJN@28890|Euryarchaeota,23QV5@183939|Methanococci	183939|Methanococci	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rpl11	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
PYH1_k127_8114470_4	186497.PF1990	3.06e-40	153.0	COG0250@1|root,arCOG01920@2157|Archaea,2XWGQ@28890|Euryarchaeota,2441S@183968|Thermococci	183968|Thermococci	K	Transcription elongation factor Spt5	spt5	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,Spt5-NGN
PYH1_k127_8114470_0	272844.PAB2025	3.04e-92	310.0	COG0552@1|root,arCOG01227@2157|Archaea,2XUBI@28890|Euryarchaeota,242QW@183968|Thermococci	183968|Thermococci	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
PYH1_k127_8124022_1	1123373.ATXI01000024_gene116	1.01e-49	182.0	COG0778@1|root,COG0778@2|Bacteria,2GHHZ@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	C	Putative TM nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
PYH1_k127_8124022_3	399550.Smar_1423	2.063e-23	113.0	COG1305@1|root,arCOG02165@2157|Archaea,2XRIK@28889|Crenarchaeota	28889|Crenarchaeota	E	transglutaminase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
PYH1_k127_8124022_0	419665.Maeo_0278	1.268e-80	274.0	COG0176@1|root,arCOG05061@2157|Archaea,2XTET@28890|Euryarchaeota,23Q23@183939|Methanococci	183939|Methanococci	F	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
PYH1_k127_8124022_2	1294142.CINTURNW_3602	1.519e-43	162.0	COG3958@1|root,COG3958@2|Bacteria,1V0K5@1239|Firmicutes,24914@186801|Clostridia,36E9P@31979|Clostridiaceae	186801|Clostridia	G	Transketolase	tktB	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
PYH1_k127_8131417_7	1151117.AJLF01000002_gene454	3.311e-17	83.0	COG0298@1|root,arCOG04427@2157|Archaea,2Y0AJ@28890|Euryarchaeota,244KI@183968|Thermococci	183968|Thermococci	O	HupF/HypC family	-	-	-	ko:K04653	-	-	-	-	ko00000	-	-	-	HupF_HypC
PYH1_k127_8131417_3	1220534.B655_0616	2.111e-47	175.0	COG0221@1|root,arCOG01711@2157|Archaea,2XTSU@28890|Euryarchaeota,23P2K@183925|Methanobacteria	183925|Methanobacteria	C	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions	-	-	3.6.1.1	ko:K01507	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyrophosphatase
PYH1_k127_8131417_0	868131.MSWAN_1834	2.543e-93	319.0	COG0075@1|root,arCOG00082@2157|Archaea,2XTWU@28890|Euryarchaeota,23NPQ@183925|Methanobacteria	183925|Methanobacteria	E	Aminotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
PYH1_k127_8131417_5	765952.PUV_11880	2.252e-36	147.0	COG1801@1|root,COG1801@2|Bacteria,2JH8Q@204428|Chlamydiae	204428|Chlamydiae	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
PYH1_k127_8131417_6	529709.PYCH_00770	3.924e-24	104.0	COG1581@1|root,arCOG01753@2157|Archaea,2XZH4@28890|Euryarchaeota,244BC@183968|Thermococci	183968|Thermococci	K	Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes	albA	-	-	ko:K03622	-	-	-	-	ko00000	-	-	-	Alba
PYH1_k127_8131417_1	309801.trd_A0521	9.337e-70	248.0	COG1446@1|root,COG1446@2|Bacteria,2G6AS@200795|Chloroflexi,27XW0@189775|Thermomicrobia	189775|Thermomicrobia	E	Asparaginase	-	-	3.4.19.5	ko:K13051	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Asparaginase_2
PYH1_k127_8131417_4	1117379.BABA_12101	4.534e-45	173.0	COG2267@1|root,COG2267@2|Bacteria,1UKWC@1239|Firmicutes,4ITKP@91061|Bacilli	91061|Bacilli	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
PYH1_k127_8131417_2	192952.MM_1396	4.026e-57	211.0	COG2219@1|root,arCOG03013@2157|Archaea,2XTDT@28890|Euryarchaeota,2N9HY@224756|Methanomicrobia	224756|Methanomicrobia	L	Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair	priL	-	-	ko:K18882	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_primase_lrg
PYH1_k127_8145517_0	688269.Theth_1319	1.002e-86	299.0	COG3653@1|root,COG3653@2|Bacteria	2|Bacteria	Q	N-Acyl-D-aspartate D-glutamate deacylase	-	-	3.5.1.81	ko:K06015	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Amidohydro_3
PYH1_k127_8145517_1	1453505.JASY01000020_gene72	5.988e-31	132.0	COG2819@1|root,COG2819@2|Bacteria,4NN8M@976|Bacteroidetes,1I1EI@117743|Flavobacteriia,2P034@237|Flavobacterium	976|Bacteroidetes	S	Putative esterase	-	-	-	ko:K07017	-	-	-	-	ko00000	-	-	-	Esterase,TPR_8
PYH1_k127_8150725_0	192952.MM_0701	1.543e-111	376.0	COG3808@1|root,arCOG04949@2157|Archaea,2XTDB@28890|Euryarchaeota,2N98C@224756|Methanomicrobia	224756|Methanomicrobia	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
PYH1_k127_8158599_0	1459636.NTE_00547	1.245e-107	359.0	COG2133@1|root,arCOG02796@2157|Archaea,41T0Q@651137|Thaumarchaeota	651137|Thaumarchaeota	G	Glucose sorbosone	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
PYH1_k127_8158599_1	1297617.JPJD01000029_gene2327	0.0007961	44.0	COG1141@1|root,COG1141@2|Bacteria,1VFD1@1239|Firmicutes,25NZ9@186801|Clostridia,269XZ@186813|unclassified Clostridiales	186801|Clostridia	C	4Fe-4S single cluster domain of Ferredoxin I	-	-	-	ko:K05337	-	-	-	-	ko00000	-	-	-	Fer4_13
PYH1_k127_8168659_3	768679.TTX_1000	1.178e-53	191.0	COG0017@1|root,arCOG00407@2157|Archaea,2XQ0M@28889|Crenarchaeota	28889|Crenarchaeota	J	PFAM tRNA synthetase, class II (D, K and N)	-	-	6.1.1.22	ko:K01893	ko00970,map00970	M00359,M00360	R03648	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
PYH1_k127_8168659_2	1041930.Mtc_1955	5.824e-62	220.0	COG0013@1|root,arCOG01254@2157|Archaea,2Y7FE@28890|Euryarchaeota	28890|Euryarchaeota	J	tRNA synthetases class II (A)	-	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2c,tRNA_SAD
PYH1_k127_8168659_1	397948.Cmaq_0116	4.291e-105	357.0	COG1680@1|root,arCOG00771@2157|Archaea,2XQ49@28889|Crenarchaeota	28889|Crenarchaeota	E	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,Pab87_oct
PYH1_k127_8168659_7	368408.Tpen_1049	2.363e-10	68.0	COG3371@1|root,arCOG02008@2157|Archaea,2XQNY@28889|Crenarchaeota	28889|Crenarchaeota	S	Protein of unknown function (DUF998)	-	-	-	-	-	-	-	-	-	-	-	-	DUF998
PYH1_k127_8168659_6	1163730.FFONT_0275	3.584e-11	70.0	COG4708@1|root,arCOG07487@2157|Archaea,2XQUI@28889|Crenarchaeota	28889|Crenarchaeota	S	QueT transporter	-	-	-	-	-	-	-	-	-	-	-	-	QueT
PYH1_k127_8168659_4	386456.JQKN01000017_gene846	6.424e-50	184.0	COG4832@1|root,arCOG03571@1|root,arCOG03201@2157|Archaea,arCOG03571@2157|Archaea,2Y3NU@28890|Euryarchaeota	28890|Euryarchaeota	S	GyrI-like small molecule binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GyrI-like
PYH1_k127_8168659_5	485916.Dtox_1038	5.271e-37	150.0	COG1387@1|root,COG1387@2|Bacteria,1TRKS@1239|Firmicutes,249TM@186801|Clostridia,266SD@186807|Peptococcaceae	186801|Clostridia	E	TIGRFAM histidinol phosphate phosphatase HisJ	-	-	3.1.3.15	ko:K04486	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03013	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PHP,PHP_C
PYH1_k127_8168659_0	69014.TK1239	3.958e-113	378.0	COG1503@1|root,arCOG01742@2157|Archaea,2XSV5@28890|Euryarchaeota,243E3@183968|Thermococci	183968|Thermococci	J	Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA	prf1	-	-	ko:K03265	ko03015,map03015	-	-	-	ko00000,ko00001,ko03012,ko03019	-	-	-	eRF1_1,eRF1_2,eRF1_3
PYH1_k127_8223505_1	266117.Rxyl_0842	6.54e-10	62.0	COG0620@1|root,COG0620@2|Bacteria	2|Bacteria	E	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation	-	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_1,Meth_synt_2
PYH1_k127_8223505_0	273068.TTE1804	7.911e-34	141.0	COG0685@1|root,COG0685@2|Bacteria,1UHX4@1239|Firmicutes,25E62@186801|Clostridia,42FH6@68295|Thermoanaerobacterales	186801|Clostridia	C	Methylenetetrahydrofolate reductase	metF	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
PYH1_k127_8228394_3	468059.AUHA01000007_gene2697	6.208e-45	170.0	2CYFR@1|root,32T44@2|Bacteria,4P6IN@976|Bacteroidetes,1IZDY@117747|Sphingobacteriia	976|Bacteroidetes	S	Protein of unknown function (DUF998)	-	-	-	-	-	-	-	-	-	-	-	-	DUF998
PYH1_k127_8228394_1	374847.Kcr_1548	4.509e-128	417.0	COG1052@1|root,arCOG01755@2157|Archaea	2157|Archaea	C	D-isomer specific 2-hydroxyacid dehydrogenase	gyaR	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0016618,GO:0030267,GO:0044424,GO:0044444,GO:0044464,GO:0055114	1.1.1.26,1.1.1.29	ko:K00015,ko:K00018	ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200	M00346	R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko00002,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
PYH1_k127_8228394_0	386456.JQKN01000002_gene2482	2.795e-213	682.0	COG1331@1|root,arCOG02007@2157|Archaea,2XU5Q@28890|Euryarchaeota	28890|Euryarchaeota	O	COG1331 Highly conserved protein containing a thioredoxin domain	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	GlcNAc_2-epim,Thioredox_DsbH
PYH1_k127_8228394_5	552811.Dehly_1193	5.357e-26	115.0	2ECVV@1|root,336T6@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_8228394_2	410358.Mlab_1687	5.759e-47	174.0	arCOG04820@1|root,arCOG04820@2157|Archaea,2XX4W@28890|Euryarchaeota	28890|Euryarchaeota	T	PFAM SOUL heme-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SOUL
PYH1_k127_8228394_4	1122176.KB903609_gene5261	1.326e-35	144.0	COG1030@1|root,COG1030@2|Bacteria,4PN0T@976|Bacteroidetes,1ITG9@117747|Sphingobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	TspO_MBR
PYH1_k127_8248527_0	573370.DMR_02770	3.46e-97	327.0	COG3261@1|root,COG3261@2|Bacteria,1QUBF@1224|Proteobacteria,43DST@68525|delta/epsilon subdivisions,2WJ4E@28221|Deltaproteobacteria,2M872@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM NADH-ubiquinone oxidoreductase chain 49kDa	-	-	1.6.5.3	ko:K00333,ko:K14090	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa,NiFeSe_Hases
PYH1_k127_8248527_1	1379698.RBG1_1C00001G0050	9.668e-69	244.0	COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria	2|Bacteria	C	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_20,Pyr_redox_2,Pyr_redox_3
PYH1_k127_8250199_0	243232.MJ_1630	1.902e-114	381.0	COG1933@1|root,arCOG04447@2157|Archaea,2XU5S@28890|Euryarchaeota,23Q0E@183939|Methanococci	183939|Methanococci	L	Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase	polC	-	2.7.7.7	ko:K02322	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	M00264	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	Intein_splicing,LAGLIDADG_3,PolC_DP2
PYH1_k127_8250199_1	868131.MSWAN_0376	2.091e-63	223.0	COG1646@1|root,arCOG01085@2157|Archaea,2XTEC@28890|Euryarchaeota,23NWS@183925|Methanobacteria	183925|Methanobacteria	H	Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids	-	-	2.5.1.41	ko:K17104	ko00564,map00564	-	R04158	RC01091	ko00000,ko00001,ko01000	-	-	-	PcrB
PYH1_k127_8266134_0	391623.TERMP_01190	3.827e-142	467.0	COG1178@1|root,arCOG00163@2157|Archaea,2XUE2@28890|Euryarchaeota,242Z4@183968|Thermococci	183968|Thermococci	P	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
PYH1_k127_8266134_1	1163730.FFONT_0743	2.611e-101	338.0	COG3839@1|root,arCOG00177@2157|Archaea,2XSPU@28889|Crenarchaeota	28889|Crenarchaeota	E	COGs COG3842 ABC-type spermidine putrescine transport systems ATPase components	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,TOBE_2
PYH1_k127_8267255_0	608538.HTH_1738	1.874e-52	192.0	COG1180@1|root,COG1180@2|Bacteria,2G49Z@200783|Aquificae	200783|Aquificae	O	Radical SAM domain protein	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Fer4_14,Radical_SAM
PYH1_k127_8267255_1	403833.Pmob_0978	1.998e-50	193.0	COG1328@1|root,COG1328@2|Bacteria,2GCC4@200918|Thermotogae	200918|Thermotogae	F	TIGRFAM Anaerobic ribonucleoside-triphosphate reductase	-	-	1.1.98.6	ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R11633,R11634,R11635,R11636	RC00613	ko00000,ko00001,ko00002,ko01000	-	-	iLJ478.TM0385	ATP-cone,NRDD
PYH1_k127_8279319_1	269797.Mbar_A0212	6.395e-12	70.0	COG0618@1|root,arCOG01565@2157|Archaea,2XWQV@28890|Euryarchaeota,2N9IY@224756|Methanomicrobia	224756|Methanomicrobia	S	DHH family	-	-	-	-	-	-	-	-	-	-	-	-	DHH,DHHA1
PYH1_k127_8279319_0	485916.Dtox_1967	2.004e-141	469.0	COG0488@1|root,COG0488@2|Bacteria,1UI2R@1239|Firmicutes,25EBF@186801|Clostridia,267CI@186807|Peptococcaceae	186801|Clostridia	S	PFAM ABC transporter related	-	-	-	ko:K16785,ko:K16786,ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran
PYH1_k127_8285819_0	1121904.ARBP01000003_gene6365	1.042e-08	58.0	COG0498@1|root,COG0498@2|Bacteria,4NKWI@976|Bacteroidetes,47SIW@768503|Cytophagia	976|Bacteroidetes	E	Pyridoxal-phosphate dependent enzyme	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	LeuA_dimer,PALP
PYH1_k127_8285819_1	186497.PF0029	7.003e-06	58.0	arCOG05346@1|root,arCOG05346@2157|Archaea,2XWG1@28890|Euryarchaeota,243XG@183968|Thermococci	183968|Thermococci	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_8298659_2	1236689.MMALV_02230	1.055e-49	185.0	COG3839@1|root,arCOG00177@2157|Archaea,2XTU1@28890|Euryarchaeota,3F2MM@33867|unclassified Euryarchaeota	28890|Euryarchaeota	E	ABC transporter	potA	-	3.6.3.29,3.6.3.30,3.6.3.31,3.6.3.55	ko:K02010,ko:K02017,ko:K02052,ko:K02062,ko:K10112,ko:K11072,ko:K15497,ko:K17240	ko02010,ko02024,map02010,map02024	M00189,M00190,M00191,M00193,M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00299,M00423,M00491,M00599,M00602,M00605,M00606	R10531	RC00002	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.1,3.A.1.1.38,3.A.1.10,3.A.1.11,3.A.1.11.1,3.A.1.19,3.A.1.6.5,3.A.1.8	-	-	ABC_tran,TOBE_2
PYH1_k127_8298659_0	1054217.TALC_00239	5.062e-85	294.0	COG3839@1|root,arCOG00177@2157|Archaea,2XSVD@28890|Euryarchaeota,241NV@183967|Thermoplasmata	28890|Euryarchaeota	E	ATPases associated with a variety of cellular activities	malK	-	-	ko:K10112,ko:K17240	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00599,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.38	-	-	ABC_tran,TOBE_2
PYH1_k127_8298659_3	591019.Shell_0654	2.344e-15	84.0	COG1392@1|root,arCOG02640@2157|Archaea,2XQYH@28889|Crenarchaeota	28889|Crenarchaeota	K	PFAM Putitive phosphate transport regulator	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
PYH1_k127_8298659_1	1434325.AZQN01000010_gene3869	5.162e-66	235.0	COG3191@1|root,COG3191@2|Bacteria,4NGDT@976|Bacteroidetes,47K9S@768503|Cytophagia	976|Bacteroidetes	EQ	Peptidase family S58	-	-	3.4.11.19	ko:K01266	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S58
PYH1_k127_8305165_0	309801.trd_0388	3.062e-103	355.0	COG1574@1|root,COG1574@2|Bacteria,2GB76@200795|Chloroflexi,27XM1@189775|Thermomicrobia	189775|Thermomicrobia	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
PYH1_k127_8305165_1	1499967.BAYZ01000038_gene2261	2.271e-83	282.0	COG0705@1|root,COG0705@2|Bacteria,2NPGI@2323|unclassified Bacteria	2|Bacteria	S	(Rhomboid) family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
PYH1_k127_830748_2	1234364.AMSF01000010_gene512	7.819e-10	62.0	COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,1RQRP@1236|Gammaproteobacteria,1X3Y7@135614|Xanthomonadales	135614|Xanthomonadales	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
PYH1_k127_830748_0	1499967.BAYZ01000028_gene1366	3.892e-91	321.0	COG3653@1|root,COG3653@2|Bacteria,2NNQ0@2323|unclassified Bacteria	2|Bacteria	Q	Amidohydrolase family	dan	-	3.5.1.81	ko:K06015	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Amidohydro_3
PYH1_k127_830748_1	756499.Desde_0044	1.587e-69	248.0	COG1600@1|root,COG1600@2|Bacteria,1V0B5@1239|Firmicutes,24FDD@186801|Clostridia,262G9@186807|Peptococcaceae	186801|Clostridia	C	TIGRFAM reductive dehalogenase	-	-	-	-	-	-	-	-	-	-	-	-	Dehalogenase,Fer4_16
PYH1_k127_8308115_0	604354.TSIB_0558	1.57e-79	285.0	COG0433@1|root,arCOG00280@2157|Archaea,2Y65Q@28890|Euryarchaeota,2450B@183968|Thermococci	183968|Thermococci	L	AAA-like domain	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF87,HAS-barrel
PYH1_k127_8308115_1	555088.DealDRAFT_0361	1.943e-16	91.0	COG0420@1|root,COG0420@2|Bacteria,1V9XH@1239|Firmicutes,24KAZ@186801|Clostridia	186801|Clostridia	L	PFAM Metallophosphoesterase	-	-	-	ko:K03547	-	-	-	-	ko00000,ko03400	-	-	-	Metallophos
PYH1_k127_8339721_1	1041930.Mtc_1660	4.69e-66	233.0	COG0265@1|root,arCOG02833@2157|Archaea,2XT7Y@28890|Euryarchaeota,2NAWS@224756|Methanomicrobia	224756|Methanomicrobia	O	Trypsin	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
PYH1_k127_8339721_0	5762.XP_002676508.1	7.31e-67	243.0	COG1506@1|root,KOG2100@2759|Eukaryota	2759|Eukaryota	E	serine-type peptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	DPPIV_N,Peptidase_S9
PYH1_k127_8345652_0	930945.SiRe_1932	1.05e-51	196.0	COG0472@1|root,arCOG03199@2157|Archaea,2XPXP@28889|Crenarchaeota	28889|Crenarchaeota	M	PFAM Glycosyl transferase family 4	-	-	2.7.8.15	ko:K01001	ko00510,ko01100,map00510,map01100	M00055	R05969	RC00002	ko00000,ko00001,ko00002,ko01000,ko01003	-	-	-	Glycos_transf_4
PYH1_k127_8345652_1	415426.Hbut_0047	7.611e-28	119.0	COG1032@1|root,arCOG01356@2157|Archaea,2XPY0@28889|Crenarchaeota	28889|Crenarchaeota	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
PYH1_k127_8345886_3	1131269.AQVV01000074_gene2052	1.231e-08	59.0	COG0285@1|root,COG0285@2|Bacteria	2|Bacteria	H	dihydrofolate synthase activity	folC	GO:0003674,GO:0003824,GO:0004326,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006761,GO:0006807,GO:0008150,GO:0008152,GO:0008841,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046452,GO:0046483,GO:0046900,GO:0046901,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	iLJ478.TM0166,iSB619.SA_RS08370	Mur_ligase_C,Mur_ligase_M
PYH1_k127_8345886_2	1128398.Curi_c20780	1.997e-33	143.0	COG2327@1|root,COG2327@2|Bacteria,1TPTI@1239|Firmicutes,248QN@186801|Clostridia,2682P@186813|unclassified Clostridiales	186801|Clostridia	M	Polysaccharide pyruvyl transferase	csaB	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1,PS_pyruv_trans
PYH1_k127_8345886_0	572478.Vdis_0455	3.828e-67	242.0	COG0438@1|root,arCOG01403@2157|Archaea	2157|Archaea	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
PYH1_k127_8345886_1	935840.JAEQ01000009_gene1420	9.441e-55	207.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,2TU67@28211|Alphaproteobacteria,43MR6@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	DegT/DnrJ/EryC1/StrS aminotransferase family	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
PYH1_k127_8347432_1	401526.TcarDRAFT_1907	1.513e-47	173.0	COG0598@1|root,COG0598@2|Bacteria,1TPSV@1239|Firmicutes,4H27G@909932|Negativicutes	909932|Negativicutes	P	transport protein CorA	corA	-	-	-	-	-	-	-	-	-	-	-	CorA
PYH1_k127_8347432_0	368408.Tpen_0269	3.136e-173	556.0	COG1690@1|root,arCOG04246@2157|Archaea,2XPMA@28889|Crenarchaeota	28889|Crenarchaeota	L	Belongs to the RtcB family	rtcB	GO:0000394,GO:0003674,GO:0003824,GO:0006139,GO:0006388,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008380,GO:0008452,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016886,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:1901360	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
PYH1_k127_8350922_0	635013.TherJR_0942	2.521e-250	789.0	COG3383@1|root,COG3383@2|Bacteria,1UI1F@1239|Firmicutes,25EAG@186801|Clostridia,260KC@186807|Peptococcaceae	186801|Clostridia	C	TIGRFAM formate dehydrogenase, alpha subunit	-	-	1.17.1.10,1.6.5.3	ko:K00336,ko:K05299	ko00190,ko00680,ko00720,ko01100,ko01120,ko01200,map00190,map00680,map00720,map01100,map01120,map01200	M00144,M00377	R00134,R11945	RC00061,RC02796	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Fer4,Fer4_6,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
PYH1_k127_8350922_1	706587.Desti_0008	2.394e-64	230.0	COG2048@1|root,COG2048@2|Bacteria,1RC7G@1224|Proteobacteria,43B85@68525|delta/epsilon subdivisions,2WMVG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Heterodisulfide reductase subunit B	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
PYH1_k127_8350922_3	679926.Mpet_2473	3.045e-07	59.0	COG2048@1|root,arCOG00964@2157|Archaea,2XXYP@28890|Euryarchaeota,2N9VF@224756|Methanomicrobia	224756|Methanomicrobia	C	heterodisulfide reductase subunit C	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03390	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_17,Fer4_8
PYH1_k127_8350922_2	694429.Pyrfu_0204	2.767e-59	211.0	COG0638@1|root,arCOG00970@2157|Archaea,2XQG7@28889|Crenarchaeota	28889|Crenarchaeota	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	psmB1	-	3.4.25.1	ko:K03433	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
PYH1_k127_8357389_0	748449.Halha_2018	3.882e-85	293.0	COG0285@1|root,COG0285@2|Bacteria,1TPX5@1239|Firmicutes,247PC@186801|Clostridia,3WAEX@53433|Halanaerobiales	186801|Clostridia	H	Mur ligase family, glutamate ligase domain	folC	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M
PYH1_k127_8357389_1	415426.Hbut_0487	9.14e-83	280.0	COG1980@1|root,arCOG04180@2157|Archaea,2XPV4@28889|Crenarchaeota	28889|Crenarchaeota	G	Catalyzes two subsequent steps in gluconeogenesis the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P)	fbp	GO:0000287,GO:0003674,GO:0003824,GO:0004332,GO:0005488,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006740,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016829,GO:0016830,GO:0016832,GO:0019203,GO:0019318,GO:0019319,GO:0019362,GO:0019637,GO:0034641,GO:0042132,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044283,GO:0046364,GO:0046483,GO:0046496,GO:0046872,GO:0050308,GO:0051186,GO:0055086,GO:0055114,GO:0071704,GO:0072524,GO:1901360,GO:1901564,GO:1901576	3.1.3.11,4.1.2.13	ko:K01622	ko00010,ko00030,ko00051,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00003	R00762,R01068,R01070,R02568,R04780	RC00017,RC00438,RC00439	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_3
PYH1_k127_8358730_0	1209989.TepiRe1_2363	1.269e-50	188.0	COG0209@1|root,COG1372@1|root,COG0209@2|Bacteria,COG1372@2|Bacteria,1TPFH@1239|Firmicutes,249EN@186801|Clostridia,42F6G@68295|Thermoanaerobacterales	186801|Clostridia	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdJ	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Intein_splicing,LAGLIDADG_3,Ribonuc_red_2_N,Ribonuc_red_lgC,Ribonuc_red_lgN,TSCPD
PYH1_k127_8358730_1	234267.Acid_2668	4.886e-35	142.0	COG0407@1|root,COG0407@2|Bacteria,3Y8YA@57723|Acidobacteria	57723|Acidobacteria	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
PYH1_k127_8362776_0	572477.Alvin_1243	2.361e-128	422.0	COG1283@1|root,COG1283@2|Bacteria,1MUDE@1224|Proteobacteria,1RNMM@1236|Gammaproteobacteria,1WXUR@135613|Chromatiales	135613|Chromatiales	P	PFAM Na Picotransporter	-	-	-	ko:K03324	-	-	-	-	ko00000,ko02000	2.A.58.2	-	-	Na_Pi_cotrans,PhoU
PYH1_k127_8362776_1	592015.HMPREF1705_02005	1.789e-23	101.0	COG2876@1|root,COG2876@2|Bacteria,3TA06@508458|Synergistetes	508458|Synergistetes	E	PFAM DAHP synthetase I	aroF	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
PYH1_k127_8365162_2	545694.TREPR_2694	1.556e-63	226.0	2CFN2@1|root,34AP1@2|Bacteria,2JA1Q@203691|Spirochaetes	203691|Spirochaetes	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
PYH1_k127_8365162_3	643648.Slip_0651	3.23e-29	127.0	COG1011@1|root,COG1011@2|Bacteria	2|Bacteria	S	phosphatase activity	-	-	3.1.3.102,3.1.3.104,3.1.3.5	ko:K07025,ko:K08723,ko:K20862	ko00230,ko00240,ko00740,ko00760,ko01100,ko01110,map00230,map00240,map00740,map00760,map01100,map01110	M00125	R00183,R00511,R00548,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346,R07280	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HAD_2,Hydrolase_like
PYH1_k127_8365162_1	868131.MSWAN_0226	5.539e-80	278.0	COG0731@1|root,arCOG04174@2157|Archaea,2XSTF@28890|Euryarchaeota,23NJR@183925|Methanobacteria	183925|Methanobacteria	C	Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe)	taw1	-	4.1.3.44	ko:K15449	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,Wyosine_form
PYH1_k127_8365162_0	37659.JNLN01000001_gene1077	1.214e-106	357.0	COG2317@1|root,COG2317@2|Bacteria,1TPS6@1239|Firmicutes,249NK@186801|Clostridia,36F32@31979|Clostridiaceae	186801|Clostridia	E	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues	-	-	3.4.17.19	ko:K01299	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M32
PYH1_k127_8368227_1	1123242.JH636434_gene3394	2.931e-28	122.0	COG0526@1|root,COG0526@2|Bacteria,2IZW1@203682|Planctomycetes	203682|Planctomycetes	CO	Thioredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_9
PYH1_k127_8368227_3	27923.ML218818a-PA	0.0007853	51.0	28M73@1|root,2QTQ3@2759|Eukaryota,39RFK@33154|Opisthokonta,3BEUV@33208|Metazoa	33208|Metazoa	S	Neuroblast differentiation-associated protein	AHNAK2	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005789,GO:0012505,GO:0016020,GO:0031984,GO:0042175,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0098827	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_8368227_0	498848.TaqDRAFT_4341	8.798e-32	131.0	COG0006@1|root,COG0006@2|Bacteria,1WIXQ@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	PFAM Metallopeptidase family M24	-	-	3.4.11.9,3.4.13.9	ko:K01262,ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
PYH1_k127_8368415_3	368408.Tpen_0881	2.746e-06	49.0	COG1313@1|root,arCOG00934@2157|Archaea,2XPK3@28889|Crenarchaeota	28889|Crenarchaeota	C	PFAM Radical SAM domain protein	-	-	1.97.1.4	ko:K04070	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
PYH1_k127_8368415_0	1183377.Py04_1173	7.669e-66	231.0	COG1313@1|root,arCOG00934@2157|Archaea,2XUM6@28890|Euryarchaeota,242QN@183968|Thermococci	183968|Thermococci	O	4Fe-4S single cluster domain	-	-	1.97.1.4	ko:K04070	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
PYH1_k127_8368415_1	1459636.NTE_01839	5.688e-56	203.0	COG0638@1|root,arCOG00971@2157|Archaea,41SYA@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Proteasome endopeptidase complex	-	-	3.4.25.1	ko:K03432	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome,Proteasome_A_N
PYH1_k127_8368415_2	936596.HMPREF1495_2366	3.583e-07	51.0	COG0454@1|root,COG0456@2|Bacteria,1UHZS@1239|Firmicutes,25E8H@186801|Clostridia	186801|Clostridia	K	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
PYH1_k127_85229_1	1114972.AUAW01000008_gene2235	8.79e-05	45.0	COG1052@1|root,COG1052@2|Bacteria,1TPCX@1239|Firmicutes,4HASY@91061|Bacilli,3F4Z6@33958|Lactobacillaceae	91061|Bacilli	CH	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
PYH1_k127_861112_0	1382306.JNIM01000001_gene4085	4.376e-24	110.0	COG0407@1|root,COG0407@2|Bacteria,2G6BE@200795|Chloroflexi	200795|Chloroflexi	H	PFAM Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
PYH1_k127_861628_1	589924.Ferp_0139	1.313e-47	179.0	COG1148@1|root,COG1908@1|root,arCOG02235@2157|Archaea,arCOG02476@2157|Archaea,2XT3X@28890|Euryarchaeota,245U1@183980|Archaeoglobi	183980|Archaeoglobi	C	Heterodisulfide reductase subunit A and related polyferredoxins	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,FlpD,Pyr_redox_2
PYH1_k127_861628_3	453591.Igni_0308	2.617e-06	53.0	COG1522@1|root,arCOG01117@2157|Archaea,2XR1K@28889|Crenarchaeota	28889|Crenarchaeota	K	PFAM regulatory protein AsnC Lrp family	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
PYH1_k127_861628_2	768679.TTX_1152	1.234e-06	53.0	COG1522@1|root,arCOG01117@2157|Archaea,2XQQ4@28889|Crenarchaeota	28889|Crenarchaeota	K	PFAM regulatory protein AsnC Lrp family	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
PYH1_k127_861628_0	1449126.JQKL01000010_gene463	1.11e-176	563.0	COG0493@1|root,COG0493@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,267YC@186813|unclassified Clostridiales	186801|Clostridia	C	Psort location Cytoplasmic, score	gltA	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
PYH1_k127_902833_1	436308.Nmar_1072	1.635e-173	560.0	COG0028@1|root,arCOG01998@2157|Archaea,41S63@651137|Thaumarchaeota	651137|Thaumarchaeota	E	TIGRFAM acetolactate synthase, large subunit, biosynthetic type	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
PYH1_k127_902833_2	339860.Msp_0028	9.615e-40	153.0	COG0440@1|root,arCOG04445@2157|Archaea,2XVFX@28890|Euryarchaeota,23P3W@183925|Methanobacteria	183925|Methanobacteria	E	Acetolactate synthase, small subunit	ilvN	-	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,ACT_5,ALS_ss_C
PYH1_k127_902833_0	865861.AZSU01000006_gene1195	8.072e-229	740.0	COG0474@1|root,COG0474@2|Bacteria,1TPF5@1239|Firmicutes,247JN@186801|Clostridia,36DDM@31979|Clostridiaceae	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	pacL	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
PYH1_k127_908117_1	56780.SYN_02428	3.09e-44	169.0	COG1633@1|root,COG1633@2|Bacteria	2|Bacteria	S	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
PYH1_k127_908117_0	909663.KI867151_gene2999	1.764e-48	177.0	COG1848@1|root,COG1848@2|Bacteria,1MYDN@1224|Proteobacteria,42X7T@68525|delta/epsilon subdivisions,2WT7N@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	PIN
PYH1_k127_908117_2	269799.Gmet_3077	1.962e-29	119.0	COG4118@1|root,COG4118@2|Bacteria,1P7XR@1224|Proteobacteria,4327E@68525|delta/epsilon subdivisions,2WY4C@28221|Deltaproteobacteria	28221|Deltaproteobacteria	D	Antitoxin Phd_YefM, type II toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
PYH1_k127_928948_0	760568.Desku_0815	1.132e-82	291.0	COG1053@1|root,COG1053@2|Bacteria,1TPAR@1239|Firmicutes,247SY@186801|Clostridia	186801|Clostridia	C	PFAM fumarate reductase succinate dehydrogenase flavoprotein	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_2,Succ_DH_flav_C
PYH1_k127_929204_2	877455.Metbo_1890	8.849e-19	89.0	COG1637@1|root,arCOG01304@2157|Archaea,2XUC8@28890|Euryarchaeota,23P0F@183925|Methanobacteria	183925|Methanobacteria	L	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures	nucS	-	-	ko:K07503	-	-	-	-	ko00000,ko01000	-	-	-	NucS
PYH1_k127_929204_1	374847.Kcr_0632	1.152e-122	405.0	COG0156@1|root,arCOG00113@2157|Archaea	2157|Archaea	E	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide	bioF	-	2.3.1.29,2.3.1.47,4.1.2.48	ko:K00639,ko:K00652,ko:K01620	ko00260,ko00780,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00780,map01100,map01110,map01120,map01130,map01230	M00123,M00573,M00577	R00371,R00751,R03210,R06171,R10124	RC00004,RC00039,RC00312,RC00372,RC00394,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
PYH1_k127_929204_0	1047013.AQSP01000059_gene2098	2.668e-123	402.0	COG0451@1|root,COG0451@2|Bacteria,2NQD6@2323|unclassified Bacteria	2|Bacteria	GM	RmlD substrate binding domain	ltd	-	4.2.1.45	ko:K01709	ko00520,map00520	-	R02426	RC00402	ko00000,ko00001,ko01000	-	-	-	Epimerase
PYH1_k127_93634_1	1094980.Mpsy_2167	2.671e-08	64.0	arCOG06562@1|root,arCOG06562@2157|Archaea,2Y5QT@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH1_k127_93634_0	521045.Kole_0510	6.727e-61	220.0	COG0285@1|root,COG0285@2|Bacteria,2GC0X@200918|Thermotogae	200918|Thermotogae	H	Belongs to the folylpolyglutamate synthase family	-	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M
PYH1_k127_982570_0	909663.KI867150_gene284	3.51e-171	548.0	COG0281@1|root,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,42MDI@68525|delta/epsilon subdivisions,2WIVY@28221|Deltaproteobacteria,2MQ89@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Malic enzyme, NAD binding domain	maeB	-	1.1.1.38,1.1.1.40	ko:K00027,ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,ko02020,map00620,map00710,map01100,map01120,map01200,map02020	M00169,M00172	R00214,R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1637	Malic_M,PTA_PTB,malic
PYH1_k127_982570_1	386456.JQKN01000001_gene2212	1.679e-30	129.0	COG1148@1|root,arCOG02236@2157|Archaea,2XV85@28890|Euryarchaeota,23PDJ@183925|Methanobacteria	183925|Methanobacteria	C	PFAM Methyl-viologen-reducing hydrogenase, delta subunit	-	-	1.8.7.3	ko:K22480	ko00680,map00680	-	R11931	RC00011	ko00000,ko00001,ko01000	-	-	-	Fer4,Fer4_7,FlpD,NAD_binding_8,Pyr_redox_2
## 1200 queries scanned
## Total time (seconds): 53.74539875984192
## Rate: 22.33 q/s