## Thu Oct 17 12:39:17 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/Potential_rubisco_autotrophic/PYH3_bin.29.fa -m mmseqs --itype genome -o PYH3_bin.29 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/all_bins_1385/PYH3_bin.29 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
PYH3_k127_1074940_1	1487921.DP68_18345	6.403e-15	86.0	COG1131@1|root,COG1131@2|Bacteria,1TPMQ@1239|Firmicutes,248QD@186801|Clostridia,36DTX@31979|Clostridiaceae	186801|Clostridia	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
PYH3_k127_1074940_2	870967.VIS19158_03137	0.0003393	52.0	COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,1RPB4@1236|Gammaproteobacteria,1XT9F@135623|Vibrionales	135623|Vibrionales	V	Transport permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
PYH3_k127_1074940_0	868131.MSWAN_0063	6.149e-19	91.0	COG1208@1|root,arCOG00663@2157|Archaea,2XUID@28890|Euryarchaeota,23NN0@183925|Methanobacteria	183925|Methanobacteria	M	PFAM Nucleotidyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,MannoseP_isomer,NTP_transferase
PYH3_k127_109550_1	195522.BD01_1774	8.831e-20	100.0	COG0524@1|root,arCOG00014@2157|Archaea,2Y67H@28890|Euryarchaeota,2431X@183968|Thermococci	183968|Thermococci	G	Belongs to the carbohydrate kinase PfkB family	-	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0019200,GO:0044237,GO:0044238,GO:0044262,GO:0044424,GO:0044464,GO:0046835,GO:0071704	2.7.1.213	ko:K21057	ko00240,map00240	-	R00513,R00964,R01666	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
PYH3_k127_109550_0	1131269.AQVV01000017_gene1962	1.733e-26	117.0	COG1166@1|root,COG1166@2|Bacteria	2|Bacteria	H	arginine decarboxylase activity	speA	GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008792,GO:0009056,GO:0009058,GO:0009063,GO:0009064,GO:0009065,GO:0009308,GO:0009309,GO:0009445,GO:0009446,GO:0009987,GO:0016054,GO:0016829,GO:0016830,GO:0016831,GO:0019752,GO:0034641,GO:0042401,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044271,GO:0044281,GO:0044282,GO:0046395,GO:0071704,GO:0097164,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606	4.1.1.19	ko:K01585	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	iAPECO1_1312.APECO1_3590,iE2348C_1286.E2348C_3191,iEC55989_1330.EC55989_3231,iECABU_c1320.ECABU_c32250,iECED1_1282.ECED1_3401,iECIAI1_1343.ECIAI1_3071,iECIAI39_1322.ECIAI39_3358,iECO103_1326.ECO103_3518,iECO26_1355.ECO26_4037,iECOK1_1307.ECOK1_3327,iECP_1309.ECP_2933,iECS88_1305.ECS88_3221,iECSE_1348.ECSE_3207,iECSF_1327.ECSF_2737,iECSP_1301.ECSP_3909,iECUMN_1333.ECUMN_3290,iECW_1372.ECW_m3198,iECs_1301.ECs3814,iEKO11_1354.EKO11_0788,iEcE24377_1341.EcE24377A_3281,iEcHS_1320.EcHS_A3096,iEcolC_1368.EcolC_0773,iG2583_1286.G2583_3597,iIT341.HP0422,iLF82_1304.LF82_2157,iNRG857_1313.NRG857_14440,iPC815.YPO0929,iSBO_1134.SBO_3051,iSDY_1059.SDY_3134,iSSON_1240.SSON_3092,iSbBS512_1146.SbBS512_E3371,iWFL_1372.ECW_m3198,iZ_1308.Z4283	Orn_Arg_deC_N
PYH3_k127_1167949_3	768710.DesyoDRAFT_0766	2.573e-52	197.0	COG0491@1|root,COG0491@2|Bacteria,1V62I@1239|Firmicutes,24I5E@186801|Clostridia,261TE@186807|Peptococcaceae	186801|Clostridia	S	Zn-dependent hydrolase, glyoxylase	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
PYH3_k127_1167949_4	390989.JOEG01000008_gene1450	9.469e-11	72.0	COG1011@1|root,COG1011@2|Bacteria	2|Bacteria	S	phosphatase activity	-	-	3.1.3.10	ko:K07025,ko:K20866	ko00010,ko01120,map00010,map01120	-	R00947	RC00078	ko00000,ko00001,ko01000	-	-	-	HAD_2,Hydrolase,Hydrolase_like
PYH3_k127_1167949_0	1220534.B655_0356	9.246e-85	302.0	COG0294@1|root,arCOG01978@2157|Archaea,2XTEW@28890|Euryarchaeota,23NP0@183925|Methanobacteria	183925|Methanobacteria	H	TIGRFAM dihydropteroate synthase-related protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF4346,Pterin_bind
PYH3_k127_1167949_2	69014.TK0293	3.804e-57	208.0	COG1634@1|root,arCOG04303@2157|Archaea,2XT8R@28890|Euryarchaeota,24344@183968|Thermococci	183968|Thermococci	H	Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6- hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP)	mptE	-	2.7.6.3	ko:K07142	ko00790,map00790	-	R03503	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	MAF_flag10
PYH3_k127_1167949_1	1041930.Mtc_1062	1.677e-65	235.0	COG1469@1|root,arCOG04301@2157|Archaea,2XT11@28890|Euryarchaeota,2N944@224756|Methanomicrobia	224756|Methanomicrobia	H	Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin	mptA	-	3.5.4.39	ko:K17488	ko00790,map00790	-	R10348	RC02504,RC03131	ko00000,ko00001,ko01000	-	-	-	GCHY-1
PYH3_k127_1167949_5	1166016.W5S_0446	9.16e-09	63.0	2AJ9K@1|root,319UK@2|Bacteria,1QFM3@1224|Proteobacteria,1TCWG@1236|Gammaproteobacteria,1MTPI@122277|Pectobacterium	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_1203316_2	247490.KSU1_C1165	2.863e-24	105.0	COG0388@1|root,COG0388@2|Bacteria,2IXKW@203682|Planctomycetes	203682|Planctomycetes	S	PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	3.5.1.6	ko:K01431	ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100	M00046	R00905,R04666,R08228	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase
PYH3_k127_1203316_5	1219084.AP014508_gene890	2.489e-07	60.0	COG2220@1|root,COG2220@2|Bacteria,2GC31@200918|Thermotogae	200918|Thermotogae	S	Belongs to the UPF0173 family	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2,Lactamase_B_3
PYH3_k127_1203316_1	339860.Msp_0857	6.903e-34	148.0	COG1608@1|root,arCOG00860@2157|Archaea,2XSUI@28890|Euryarchaeota,23NXS@183925|Methanobacteria	183925|Methanobacteria	I	Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids	-	-	2.7.4.26	ko:K06981	ko00900,ko01110,ko01130,map00900,map01110,map01130	-	R10093	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
PYH3_k127_1203316_3	1408422.JHYF01000016_gene131	1.576e-23	115.0	arCOG11023@1|root,2ZBVW@2|Bacteria,1V1HI@1239|Firmicutes,24G3M@186801|Clostridia,36INM@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_1203316_0	5888.CAK64288	3.301e-36	144.0	COG1100@1|root,KOG0098@2759|Eukaryota,3ZBJN@5878|Ciliophora	5878|Ciliophora	U	Rab subfamily of small GTPases	-	-	-	ko:K07877	ko04152,map04152	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	Ras
PYH3_k127_1203316_4	349161.Dred_0517	6.738e-08	65.0	2BCHK@1|root,3263H@2|Bacteria,1US2N@1239|Firmicutes,24YAW@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_1219569_5	420247.Msm_0107	7.638e-34	133.0	COG0378@1|root,arCOG01231@2157|Archaea,2XUJS@28890|Euryarchaeota,23NUM@183925|Methanobacteria	183925|Methanobacteria	O	Hydrogenase accessory protein HypB	hypB	-	-	ko:K04652	-	-	-	-	ko00000,ko03110	-	-	-	cobW
PYH3_k127_1219569_6	118168.MC7420_6634	4.661e-15	80.0	COG2018@1|root,COG2018@2|Bacteria,1G7A5@1117|Cyanobacteria,1HBDJ@1150|Oscillatoriales	1117|Cyanobacteria	S	Roadblock/LC7 domain	-	-	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
PYH3_k127_1219569_4	1365176.N186_05185	4.719e-36	149.0	COG1829@1|root,arCOG04263@2157|Archaea,2XQG1@28889|Crenarchaeota	28889|Crenarchaeota	S	kinase, sugar kinase superfamily	-	-	2.7.1.169	ko:K06982	ko00770,ko01100,map00770,map01100	-	R09378	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	GHMP_kinases_N
PYH3_k127_1219569_2	1459636.NTE_02599	1.024e-56	210.0	COG1829@1|root,arCOG04263@2157|Archaea,41T1V@651137|Thaumarchaeota	651137|Thaumarchaeota	S	kinase, sugar kinase superfamily	-	-	2.7.1.169	ko:K06982	ko00770,ko01100,map00770,map01100	-	R09378	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	GHMP_kinases_N
PYH3_k127_1219569_0	410359.Pcal_0384	2.369e-81	278.0	COG1701@1|root,arCOG04262@2157|Archaea,2XPPD@28889|Crenarchaeota	28889|Crenarchaeota	S	Pantothenate synthetase	-	-	6.3.2.36	ko:K09722	ko00410,ko00770,ko01100,map00410,map00770,map01100	-	R09379	RC00096,RC00141	ko00000,ko00001,ko01000	-	-	-	PPS_PS
PYH3_k127_1219569_3	1408419.JHYG01000004_gene1277	1.07e-47	182.0	COG1893@1|root,COG1893@2|Bacteria,1P0AW@1224|Proteobacteria,2VEXI@28211|Alphaproteobacteria,2JTEG@204441|Rhodospirillales	204441|Rhodospirillales	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
PYH3_k127_1219569_1	1123274.KB899428_gene1837	2.367e-76	265.0	COG0413@1|root,COG0413@2|Bacteria,2J6TG@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
PYH3_k127_1232626_10	529709.PYCH_10300	5.385e-05	54.0	COG2064@1|root,arCOG01812@2157|Archaea,2Y671@28890|Euryarchaeota,242WY@183968|Thermococci	183968|Thermococci	N	Type II secretion system (T2SS), protein F	-	-	-	ko:K07333	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSF
PYH3_k127_1232626_7	374847.Kcr_1320	2.706e-19	103.0	COG4962@1|root,arCOG01818@2157|Archaea	2157|Archaea	U	COG0630 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis	pilB2	-	-	ko:K07332	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
PYH3_k127_1232626_8	1324957.K933_09327	2.16e-17	94.0	COG1405@1|root,arCOG01981@2157|Archaea,2XSYE@28890|Euryarchaeota,23SMK@183963|Halobacteria	183963|Halobacteria	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	tfbA3	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
PYH3_k127_1232626_6	933801.Ahos_0802	9.697e-24	106.0	COG1958@1|root,arCOG00999@2157|Archaea,2XR1U@28889|Crenarchaeota	28889|Crenarchaeota	K	PFAM Like-Sm ribonucleoprotein, core	-	-	-	-	-	-	-	-	-	-	-	-	LSM,Lsm_C,SM-ATX
PYH3_k127_1232626_0	694429.Pyrfu_0098	1.787e-113	386.0	COG0343@1|root,arCOG00989@2157|Archaea,2XPSY@28889|Crenarchaeota	28889|Crenarchaeota	J	Exchanges the guanine residue with 7-cyano-7- deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D- loop) of archaeal tRNAs	tgtA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046116,GO:0046483,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.2.48	ko:K18779	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TGT
PYH3_k127_1232626_9	399550.Smar_0906	6.846e-13	74.0	COG1383@1|root,arCOG01885@2157|Archaea,2XR16@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eS17 family	rps17e	-	-	ko:K02962	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17e
PYH3_k127_1232626_4	633148.Tagg_1147	2.403e-37	153.0	COG1475@1|root,arCOG01875@2157|Archaea,2XR7V@28889|Crenarchaeota	28889|Crenarchaeota	K	PFAM ParB domain protein nuclease	-	-	-	-	-	-	-	-	-	-	-	-	ParBc
PYH3_k127_1232626_5	565033.GACE_1538	9.841e-32	134.0	COG2047@1|root,arCOG00348@2157|Archaea,2XSX4@28890|Euryarchaeota,2463Z@183980|Archaeoglobi	183980|Archaeoglobi	S	PAC2 family	-	-	-	ko:K07159	-	-	-	-	ko00000	-	-	-	PAC2
PYH3_k127_1232626_1	593117.TGAM_1725	4.755e-99	330.0	COG2820@1|root,arCOG01324@2157|Archaea,2XSWN@28890|Euryarchaeota,243RY@183968|Thermococci	183968|Thermococci	F	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis	-	-	2.4.2.3	ko:K00757	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01876,R02484,R08229	RC00063	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
PYH3_k127_1232626_3	351160.RCIX1920	8.685e-51	190.0	COG0110@1|root,arCOG01848@2157|Archaea,2XWJM@28890|Euryarchaeota,2N98J@224756|Methanomicrobia	224756|Methanomicrobia	S	transferase hexapeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep,Hexapep_2
PYH3_k127_1232626_2	192952.MM_1153	1.165e-66	235.0	COG0673@1|root,arCOG01622@2157|Archaea,2XTZY@28890|Euryarchaeota,2N9E7@224756|Methanomicrobia	224756|Methanomicrobia	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	1.1.1.374	ko:K18855	-	-	-	-	ko00000,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
PYH3_k127_1235658_5	224325.AF_0965	8.877e-37	148.0	COG1545@1|root,arCOG01287@2157|Archaea,2Y3J3@28890|Euryarchaeota,24718@183980|Archaeoglobi	183980|Archaeoglobi	S	Rubredoxin-like zinc ribbon domain (DUF35_N)	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
PYH3_k127_1235658_4	387631.Asulf_00172	1.202e-56	202.0	COG1545@1|root,arCOG01287@2157|Archaea,2Y2YT@28890|Euryarchaeota,246S2@183980|Archaeoglobi	183980|Archaeoglobi	S	DUF35 OB-fold domain, acyl-CoA-associated	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
PYH3_k127_1235658_0	1379698.RBG1_1C00001G1464	5.323e-185	584.0	COG0183@1|root,COG0183@2|Bacteria,2NP9T@2323|unclassified Bacteria	2|Bacteria	I	Belongs to the thiolase family	ltp4	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C
PYH3_k127_1235658_1	589924.Ferp_2555	7.168e-118	391.0	COG0183@1|root,arCOG01279@2157|Archaea,2Y2G9@28890|Euryarchaeota,246XN@183980|Archaeoglobi	183980|Archaeoglobi	I	Thiolase, C-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C
PYH3_k127_1235658_3	309807.SRU_0049	3.096e-83	288.0	COG2309@1|root,COG2309@2|Bacteria,4NRU3@976|Bacteroidetes	976|Bacteroidetes	E	Thermophilic metalloprotease (M29)	-	-	-	ko:K19689	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M29
PYH3_k127_1235658_2	572546.Arcpr_1724	7.524e-100	339.0	COG1032@1|root,arCOG01357@2157|Archaea,2XUCZ@28890|Euryarchaeota,246Y8@183980|Archaeoglobi	183980|Archaeoglobi	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
PYH3_k127_1315378_1	886293.Sinac_1235	7.939e-15	81.0	COG0189@1|root,COG0189@2|Bacteria,2IWYK@203682|Planctomycetes	203682|Planctomycetes	HJ	Belongs to the RimK family	-	-	-	ko:K05844	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	GSH-S_N,RimK
PYH3_k127_1315378_0	42256.RradSPS_0871	1.159e-69	244.0	COG1478@1|root,COG1478@2|Bacteria,2GMJ8@201174|Actinobacteria,4CQ5F@84995|Rubrobacteria	84995|Rubrobacteria	C	F420-0:Gamma-glutamyl ligase	-	-	6.3.2.31,6.3.2.34	ko:K12234	ko00680,ko01120,map00680,map01120	M00378	R09399,R09400	RC00064,RC00090,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_ligase
PYH3_k127_13424_1	1206731.BAGB01000046_gene5795	3.492e-46	186.0	COG5316@1|root,COG5316@2|Bacteria,2GN81@201174|Actinobacteria,4FZQT@85025|Nocardiaceae	201174|Actinobacteria	S	Domain of unknown function (DUF4139)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4139,DUF4140
PYH3_k127_13424_0	926692.AZYG01000085_gene825	3.277e-193	633.0	COG1501@1|root,COG1501@2|Bacteria,1TR8N@1239|Firmicutes,24A10@186801|Clostridia,3WAHR@53433|Halanaerobiales	186801|Clostridia	G	PFAM Glycosyl hydrolases family 31	-	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	DUF4968,DUF5110,Gal_mutarotas_2,Glyco_hydro_31
PYH3_k127_1405187_0	926569.ANT_14760	9.593e-143	467.0	COG1506@1|root,COG1506@2|Bacteria,2G5Z2@200795|Chloroflexi	200795|Chloroflexi	E	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
PYH3_k127_1405187_1	604354.TSIB_1558	1.719e-33	143.0	COG0697@1|root,arCOG00278@2157|Archaea,2XUJ2@28890|Euryarchaeota,24365@183968|Thermococci	183968|Thermococci	G	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
PYH3_k127_1465664_12	342949.PNA2_0399	2.085e-51	190.0	COG1196@1|root,arCOG00371@2157|Archaea,2XSVK@28890|Euryarchaeota,242QE@183968|Thermococci	183968|Thermococci	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
PYH3_k127_1465664_21	1151117.AJLF01000001_gene997	1.634e-18	94.0	COG1354@1|root,arCOG02610@2157|Archaea,2XT0N@28890|Euryarchaeota,2434N@183968|Thermococci	183968|Thermococci	L	Segregation and condensation protein ScpA	-	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
PYH3_k127_1465664_17	1343739.PAP_00060	2.094e-32	134.0	COG1386@1|root,arCOG02613@2157|Archaea,2XZ7Q@28890|Euryarchaeota,242WQ@183968|Thermococci	183968|Thermococci	K	Segregation and condensation complex subunit ScpB	-	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
PYH3_k127_1465664_5	1220534.B655_2351	6.703e-118	388.0	COG0309@1|root,arCOG00636@2157|Archaea,2XTAH@28890|Euryarchaeota,23NWV@183925|Methanobacteria	183925|Methanobacteria	O	TIGRFAM hydrogenase expression formation protein HypE	-	-	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
PYH3_k127_1465664_18	224325.AF_2152	1.947e-31	127.0	COG2007@1|root,arCOG04154@2157|Archaea,2XYXX@28890|Euryarchaeota,2473C@183980|Archaeoglobi	183980|Archaeoglobi	J	Ribosomal protein S8e	rps8e	-	-	ko:K02995	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8e
PYH3_k127_1465664_28	765914.ThisiDRAFT_1290	5.543e-06	54.0	COG0375@1|root,COG0375@2|Bacteria,1MZJH@1224|Proteobacteria,1S5WG@1236|Gammaproteobacteria,1WYQN@135613|Chromatiales	135613|Chromatiales	S	Probably plays a role in a hydrogenase nickel cofactor insertion step	hypA	-	-	ko:K04651	-	-	-	-	ko00000,ko03110	-	-	-	HypA
PYH3_k127_1465664_25	439481.Aboo_1413	7.065e-09	63.0	COG1400@1|root,arCOG01217@2157|Archaea,2Y68Y@28890|Euryarchaeota,3F2VA@33867|unclassified Euryarchaeota	28890|Euryarchaeota	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP	srp19	-	-	ko:K03105	ko03060,map03060	-	-	-	ko00000,ko00001,ko02044	3.A.5.7,3.A.5.9	-	-	SRP19
PYH3_k127_1465664_26	529709.PYCH_01710	2.242e-07	56.0	COG3277@1|root,arCOG02466@2157|Archaea,2Y1T0@28890|Euryarchaeota,244GS@183968|Thermococci	183968|Thermococci	J	H ACA RNA-protein complex	-	-	-	ko:K07569	-	-	-	-	ko00000,ko03009	-	-	-	Gar1
PYH3_k127_1465664_4	368407.Memar_0473	1.179e-141	456.0	COG1405@1|root,arCOG01981@2157|Archaea,2XT0Z@28890|Euryarchaeota,2N96C@224756|Methanomicrobia	224756|Methanomicrobia	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	tfb	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
PYH3_k127_1465664_29	273057.SSO0944	5.667e-05	50.0	COG1522@1|root,arCOG04153@2157|Archaea	2157|Archaea	K	COG1522 Transcriptional regulators	rpc34	-	-	-	-	-	-	-	-	-	-	-	B-block_TFIIIC,HTH_24,MarR
PYH3_k127_1465664_16	1459636.NTE_00648	1.705e-38	153.0	COG0293@1|root,arCOG00079@2157|Archaea,41SIK@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit	rlmE	-	2.1.1.166	ko:K02427	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ
PYH3_k127_1465664_9	339860.Msp_0291	2.477e-77	273.0	COG1867@1|root,arCOG01219@2157|Archaea,2XTUF@28890|Euryarchaeota,23NVN@183925|Methanobacteria	183925|Methanobacteria	J	Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups	trm1	-	2.1.1.215,2.1.1.216	ko:K00555	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TRM
PYH3_k127_1465664_19	263820.PTO0557	8.642e-27	121.0	COG1395@1|root,arCOG04152@2157|Archaea,2XTMG@28890|Euryarchaeota,241RI@183967|Thermoplasmata	183967|Thermoplasmata	K	DNA-binding transcription factor activity	-	-	-	ko:K07728	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3
PYH3_k127_1465664_23	604354.TSIB_1762	4.085e-11	70.0	COG2083@1|root,arCOG01921@2157|Archaea,2Y13G@28890|Euryarchaeota,244BU@183968|Thermococci	183968|Thermococci	S	Belongs to the UPF0216 family	-	-	-	ko:K09737	-	-	-	-	ko00000	-	-	-	DUF61
PYH3_k127_1465664_10	415426.Hbut_0031	6.146e-69	242.0	COG0513@1|root,arCOG00078@2157|Archaea,2XPRR@28889|Crenarchaeota	28889|Crenarchaeota	J	Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA	flpA	GO:0000154,GO:0000494,GO:0001510,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0006139,GO:0006325,GO:0006364,GO:0006396,GO:0006464,GO:0006479,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008213,GO:0008276,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0016074,GO:0016569,GO:0016570,GO:0016571,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0022613,GO:0031123,GO:0031126,GO:0031167,GO:0032259,GO:0033967,GO:0034470,GO:0034641,GO:0034660,GO:0034963,GO:0036009,GO:0036211,GO:0042054,GO:0042254,GO:0043144,GO:0043170,GO:0043412,GO:0043414,GO:0043628,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046483,GO:0051276,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140096,GO:0140098,GO:0140102,GO:1901360,GO:1901363,GO:1901564,GO:1990258,GO:1990259	-	ko:K04795	-	-	-	-	ko00000,ko03009	-	-	-	Fibrillarin
PYH3_k127_1465664_7	523850.TON_1299	3.49e-84	294.0	COG1498@1|root,arCOG01923@2157|Archaea,2XUEA@28890|Euryarchaeota,242JP@183968|Thermococci	183968|Thermococci	J	C D box methylation guide ribonucleoprotein complex aNOP56 subunit	-	-	-	ko:K14564	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	Nop
PYH3_k127_1465664_22	397948.Cmaq_1906	7.597e-12	67.0	COG4919@1|root,arCOG04293@2157|Archaea	2157|Archaea	J	ribosomal protein S30	rps30e	-	-	ko:K02983	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko04121	-	-	-	Ribosomal_S30
PYH3_k127_1465664_3	439481.Aboo_1085	3.132e-151	497.0	COG1243@1|root,arCOG01361@2157|Archaea,2XT9Z@28890|Euryarchaeota,3F2HC@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	Radical_SAM C-terminal domain	elp3	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.3.1.48	ko:K07739	-	-	-	-	ko00000,ko01000,ko03016,ko03036	-	-	-	Acetyltransf_1,Radical_SAM,Radical_SAM_C
PYH3_k127_1465664_2	272844.PAB2201	1.491e-175	569.0	COG0449@1|root,arCOG00057@2157|Archaea,2XTC0@28890|Euryarchaeota,243IS@183968|Thermococci	183968|Thermococci	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	GO:0003674,GO:0003824,GO:0004360,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
PYH3_k127_1465664_30	358396.C445_11467	0.0004131	46.0	COG1405@1|root,arCOG01981@2157|Archaea,2XTPF@28890|Euryarchaeota,23T60@183963|Halobacteria	183963|Halobacteria	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	-	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
PYH3_k127_1465664_20	1210908.HSB1_17810	5.618e-19	100.0	COG1474@1|root,arCOG00467@2157|Archaea,2XTRB@28890|Euryarchaeota,23S2H@183963|Halobacteria	183963|Halobacteria	L	Involved in regulation of DNA replication	cdc6	-	-	ko:K10725	-	-	-	-	ko00000,ko03032	-	-	-	AAA_16
PYH3_k127_1465664_27	694429.Pyrfu_0369	5.36e-06	57.0	arCOG00552@1|root,arCOG00552@2157|Archaea,2XR6J@28889|Crenarchaeota	28889|Crenarchaeota	L	GINS complex protein	-	-	-	ko:K09723	-	-	-	-	ko00000,ko03032	-	-	-	Sld5
PYH3_k127_1465664_1	415426.Hbut_0903	4.469e-188	609.0	COG1241@1|root,arCOG00439@2157|Archaea,2XQ2Z@28889|Crenarchaeota	28889|Crenarchaeota	L	Belongs to the MCM family	-	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K10726	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	Intein_splicing,MCM,MCM_N,MCM_OB
PYH3_k127_1465664_0	351160.RCIX575	2.159e-196	636.0	COG1204@1|root,arCOG00553@2157|Archaea,2XSV4@28890|Euryarchaeota,2N9A8@224756|Methanomicrobia	224756|Methanomicrobia	L	DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks	hel308	-	-	ko:K03726	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HHH_5,Helicase_C
PYH3_k127_1465664_8	485913.Krac_6706	1.889e-79	278.0	COG0123@1|root,COG0123@2|Bacteria,2G5X3@200795|Chloroflexi	200795|Chloroflexi	BQ	PFAM histone deacetylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
PYH3_k127_1465664_11	1365176.N186_00370	3.613e-64	231.0	COG0451@1|root,arCOG01369@2157|Archaea,2XRSX@28889|Crenarchaeota	28889|Crenarchaeota	M	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
PYH3_k127_1465664_15	384616.Pisl_0571	2.591e-39	153.0	COG1514@1|root,arCOG01736@2157|Archaea,2XQM6@28889|Crenarchaeota	28889|Crenarchaeota	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	ligT	-	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
PYH3_k127_1465664_6	224719.Abm4_1480	4.231e-99	336.0	COG1223@1|root,arCOG04163@2157|Archaea,2XUPW@28890|Euryarchaeota,23NRE@183925|Methanobacteria	183925|Methanobacteria	O	AAA ATPase	-	-	-	ko:K07392	-	-	-	-	ko00000	-	-	-	AAA
PYH3_k127_1465664_14	415426.Hbut_0338	2.126e-46	173.0	COG0237@1|root,arCOG01045@2157|Archaea,2XQTJ@28889|Crenarchaeota	28889|Crenarchaeota	F	Belongs to the UPF0200 family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_17,AAA_18
PYH3_k127_1465664_24	985053.VMUT_1750	3.693e-09	64.0	COG1931@1|root,arCOG01043@2157|Archaea,2XQU6@28889|Crenarchaeota	28889|Crenarchaeota	S	Belongs to the UPF0201 family	-	-	-	ko:K09736	-	-	-	-	ko00000	-	-	-	RNA_binding
PYH3_k127_1465664_13	279010.BL05258	9.06e-47	177.0	COG1234@1|root,COG1234@2|Bacteria,1TRGP@1239|Firmicutes,4HABM@91061|Bacilli,1ZC3J@1386|Bacillus	91061|Bacilli	S	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA	rnz	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005488,GO:0005515,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0031123,GO:0034414,GO:0034470,GO:0034641,GO:0034660,GO:0042779,GO:0042780,GO:0042781,GO:0042802,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1905267	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B,Lactamase_B_2
PYH3_k127_1506185_0	529709.PYCH_12930	1.211e-117	396.0	COG1111@1|root,arCOG00872@2157|Archaea,2XTBV@28890|Euryarchaeota,243CX@183968|Thermococci	183968|Thermococci	L	ERCC4 domain	-	-	-	ko:K10896	ko03460,map03460	M00413	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	DEAD,ERCC4,HHH_2,Helicase_C
PYH3_k127_1506185_1	641143.HMPREF9331_01979	9.099e-47	187.0	COG1541@1|root,COG1541@2|Bacteria,4PKJA@976|Bacteroidetes,1IJAQ@117743|Flavobacteriia,1EQDU@1016|Capnocytophaga	976|Bacteroidetes	H	GH3 auxin-responsive promoter	-	-	-	-	-	-	-	-	-	-	-	-	GH3
PYH3_k127_1612856_1	523850.TON_0087	5.564e-44	164.0	COG1841@1|root,arCOG04086@2157|Archaea,2XWGP@28890|Euryarchaeota,243IZ@183968|Thermococci	183968|Thermococci	J	Ribosomal protein L30	rpl30	GO:0000463,GO:0000470,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
PYH3_k127_1612856_3	1459636.NTE_03146	7.346e-26	113.0	COG0071@1|root,arCOG01833@2157|Archaea	2157|Archaea	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
PYH3_k127_1612856_4	415426.Hbut_1322	2.581e-24	111.0	COG0200@1|root,arCOG00779@2157|Archaea,2XQH0@28889|Crenarchaeota	28889|Crenarchaeota	J	Binds to the 23S rRNA	rpl15	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
PYH3_k127_1612856_0	227086.JGI_V11_88151	3.665e-105	360.0	COG0201@1|root,KOG1373@2759|Eukaryota	2759|Eukaryota	U	protein transport	SEC61A1	GO:0000322,GO:0000323,GO:0000324,GO:0001655,GO:0001700,GO:0001822,GO:0002009,GO:0002376,GO:0003674,GO:0005048,GO:0005215,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005773,GO:0005783,GO:0005784,GO:0005789,GO:0005791,GO:0005829,GO:0005886,GO:0006508,GO:0006511,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006620,GO:0006807,GO:0006810,GO:0006886,GO:0006950,GO:0006952,GO:0006955,GO:0006996,GO:0007029,GO:0007275,GO:0007391,GO:0007399,GO:0007417,GO:0007420,GO:0008104,GO:0008150,GO:0008152,GO:0008258,GO:0008320,GO:0008565,GO:0009056,GO:0009057,GO:0009605,GO:0009607,GO:0009615,GO:0009653,GO:0009790,GO:0009792,GO:0009888,GO:0009892,GO:0009894,GO:0009895,GO:0009987,GO:0010033,GO:0010243,GO:0010256,GO:0010498,GO:0010506,GO:0010507,GO:0010941,GO:0010942,GO:0010959,GO:0012505,GO:0012506,GO:0015031,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0016331,GO:0017038,GO:0019222,GO:0019538,GO:0019941,GO:0021536,GO:0021538,GO:0021986,GO:0022804,GO:0022857,GO:0022884,GO:0030139,GO:0030163,GO:0030176,GO:0030433,GO:0030659,GO:0030666,GO:0030670,GO:0030867,GO:0030900,GO:0030970,GO:0031090,GO:0031204,GO:0031224,GO:0031227,GO:0031323,GO:0031324,GO:0031329,GO:0031330,GO:0031410,GO:0031982,GO:0031984,GO:0032501,GO:0032502,GO:0032527,GO:0032879,GO:0032991,GO:0033036,GO:0033218,GO:0033365,GO:0033554,GO:0034097,GO:0034341,GO:0034613,GO:0034756,GO:0034758,GO:0034759,GO:0034761,GO:0034762,GO:0034764,GO:0034765,GO:0034767,GO:0034976,GO:0036503,GO:0039019,GO:0042175,GO:0042221,GO:0042277,GO:0042335,GO:0042886,GO:0042887,GO:0043021,GO:0043022,GO:0043161,GO:0043170,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043269,GO:0043270,GO:0043632,GO:0043900,GO:0043902,GO:0043903,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044433,GO:0044444,GO:0044446,GO:0044464,GO:0044743,GO:0044877,GO:0045047,GO:0045087,GO:0045169,GO:0045184,GO:0045335,GO:0046596,GO:0046598,GO:0046907,GO:0048513,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048524,GO:0048598,GO:0048729,GO:0048731,GO:0048793,GO:0048856,GO:0050789,GO:0050792,GO:0050794,GO:0050896,GO:0051049,GO:0051050,GO:0051179,GO:0051234,GO:0051603,GO:0051641,GO:0051649,GO:0051704,GO:0051707,GO:0051716,GO:0055085,GO:0060322,GO:0060429,GO:0065002,GO:0065007,GO:0070727,GO:0070843,GO:0070972,GO:0071256,GO:0071261,GO:0071702,GO:0071704,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072001,GO:0072006,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:0097708,GO:0098586,GO:0098588,GO:0098796,GO:0098805,GO:0098827,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1903513,GO:1903900,GO:1903902,GO:1904062,GO:1904064,GO:1904680	-	ko:K10956	ko03060,ko04141,ko04145,ko05110,map03060,map04141,map04145,map05110	M00401	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.4,3.A.5.8,3.A.5.9	-	-	Plug_translocon,SecY
PYH3_k127_1612856_2	579137.Metvu_0207	7.433e-43	167.0	COG2019@1|root,arCOG01039@2157|Archaea,2XVK7@28890|Euryarchaeota,23Q7F@183939|Methanococci	183939|Methanococci	F	ATP-AMP transphosphorylase	adkA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AAA_17
PYH3_k127_1612856_5	224719.Abm4_1251	1.301e-05	54.0	COG1422@1|root,arCOG02673@2157|Archaea,2XSX8@28890|Euryarchaeota,23P4B@183925|Methanobacteria	183925|Methanobacteria	U	Integral membrane protein DUF106	-	-	-	-	-	-	-	-	-	-	-	-	DUF106
PYH3_k127_1628218_12	243164.DET0783	4.935e-09	59.0	COG2178@1|root,COG2178@2|Bacteria,2G6RW@200795|Chloroflexi,34CS2@301297|Dehalococcoidia	301297|Dehalococcoidia	J	PFAM Translin	-	-	-	ko:K07477	-	-	-	-	ko00000	-	-	-	-
PYH3_k127_1628218_6	549.BW31_03044	3.207e-51	190.0	COG1515@1|root,COG1515@2|Bacteria,1MWRN@1224|Proteobacteria,1RRYH@1236|Gammaproteobacteria,3VZHQ@53335|Pantoea	1236|Gammaproteobacteria	L	DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA	nfi	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0016888,GO:0016893,GO:0034641,GO:0043170,GO:0043737,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360	3.1.21.7	ko:K05982	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Endonuclease_5
PYH3_k127_1628218_7	1041930.Mtc_0175	4.863e-49	183.0	COG1339@1|root,arCOG01904@2157|Archaea,2XTFW@28890|Euryarchaeota,2N9NG@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN)	ribK	-	2.7.1.161	ko:K07732	ko00740,ko01100,map00740,map01100	-	R08574	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	CTP-dep_RFKase,HTH_24,MarR
PYH3_k127_1628218_8	453591.Igni_1040	2.286e-28	119.0	COG0615@1|root,COG1849@1|root,arCOG01222@2157|Archaea,arCOG01224@2157|Archaea,2XQ8K@28889|Crenarchaeota	28889|Crenarchaeota	M	TIGRFAM cytidyltransferase-related domain	-	-	2.7.7.2	ko:K14656	ko00740,ko01100,ko01110,map00740,map01100,map01110	-	R00161	RC00002	ko00000,ko00001,ko01000	-	-	-	CTP_transf_like,DUF357
PYH3_k127_1628218_5	1459636.NTE_02945	1.055e-54	204.0	COG0611@1|root,arCOG00638@2157|Archaea,41SIN@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
PYH3_k127_1628218_9	1396418.BATQ01000085_gene1076	3.709e-24	118.0	COG1541@1|root,COG1541@2|Bacteria,46UTU@74201|Verrucomicrobia,2ITXN@203494|Verrucomicrobiae	203494|Verrucomicrobiae	H	AMP-binding enzyme	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding
PYH3_k127_1628218_10	529818.AMSG_11692T0	8.327e-18	85.0	COG0491@1|root,COG1758@1|root,KOG0813@2759|Eukaryota,KOG3405@2759|Eukaryota	2759|Eukaryota	K	DNA-directed 5'-3' RNA polymerase activity	HAGH	GO:0000003,GO:0000375,GO:0000377,GO:0000398,GO:0000418,GO:0000419,GO:0000428,GO:0001650,GO:0001666,GO:0003674,GO:0003824,GO:0003899,GO:0004416,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005665,GO:0005666,GO:0005730,GO:0005736,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006082,GO:0006089,GO:0006090,GO:0006139,GO:0006259,GO:0006281,GO:0006283,GO:0006289,GO:0006351,GO:0006352,GO:0006353,GO:0006354,GO:0006360,GO:0006361,GO:0006363,GO:0006366,GO:0006367,GO:0006368,GO:0006370,GO:0006383,GO:0006396,GO:0006397,GO:0006399,GO:0006518,GO:0006575,GO:0006725,GO:0006732,GO:0006749,GO:0006750,GO:0006766,GO:0006767,GO:0006790,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0007165,GO:0007166,GO:0007167,GO:0007169,GO:0007276,GO:0007283,GO:0008150,GO:0008152,GO:0008380,GO:0008543,GO:0009056,GO:0009058,GO:0009059,GO:0009108,GO:0009110,GO:0009301,GO:0009304,GO:0009438,GO:0009452,GO:0009628,GO:0009636,GO:0009719,GO:0009893,GO:0009987,GO:0010033,GO:0010467,GO:0010468,GO:0010604,GO:0010628,GO:0016051,GO:0016053,GO:0016070,GO:0016071,GO:0016073,GO:0016591,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016790,GO:0018130,GO:0019184,GO:0019222,GO:0019243,GO:0019438,GO:0019752,GO:0019852,GO:0019853,GO:0019953,GO:0022414,GO:0023052,GO:0030880,GO:0031974,GO:0031981,GO:0032501,GO:0032502,GO:0032504,GO:0032774,GO:0032787,GO:0032991,GO:0033554,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0034660,GO:0036260,GO:0036293,GO:0040029,GO:0042180,GO:0042182,GO:0042221,GO:0042364,GO:0042398,GO:0042795,GO:0042797,GO:0043043,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044271,GO:0044272,GO:0044281,GO:0044282,GO:0044283,GO:0044344,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044451,GO:0044452,GO:0044464,GO:0044703,GO:0045815,GO:0046185,GO:0046364,GO:0046394,GO:0046483,GO:0048232,GO:0048518,GO:0048609,GO:0050789,GO:0050794,GO:0050896,GO:0051186,GO:0051188,GO:0051596,GO:0051704,GO:0051716,GO:0055029,GO:0060147,GO:0060255,GO:0060964,GO:0060966,GO:0060968,GO:0061695,GO:0061727,GO:0065007,GO:0070013,GO:0070482,GO:0070848,GO:0070887,GO:0071310,GO:0071363,GO:0071495,GO:0071704,GO:0071774,GO:0090304,GO:0097237,GO:0097659,GO:0097747,GO:0098754,GO:0098781,GO:0140098,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1902494,GO:1990234,GO:1990748	2.3.2.27,2.7.1.23,2.7.7.6,3.1.2.6	ko:K00858,ko:K00960,ko:K01069,ko:K03014,ko:K15687	ko00230,ko00240,ko00620,ko00760,ko01100,ko03020,ko04623,ko05016,ko05169,map00230,map00240,map00620,map00760,map01100,map03020,map04623,map05016,map05169	M00180,M00181,M00182	R00104,R00435,R00441,R00442,R00443,R01736	RC00002,RC00004,RC00078,RC00137,RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400,ko04121	-	-	-	HAGH_C,Lactamase_B,RNA_pol_Rpb6
PYH3_k127_1628218_0	673860.AciM339_1242	2.497e-206	655.0	COG0459@1|root,arCOG01257@2157|Archaea,2XUDQ@28890|Euryarchaeota,3F2WH@33867|unclassified Euryarchaeota	28890|Euryarchaeota	O	TCP-1/cpn60 chaperonin family	thsA	GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0044183,GO:0051082,GO:0061077	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
PYH3_k127_1628218_4	795359.TOPB45_1372	1.704e-95	325.0	COG1180@1|root,COG1180@2|Bacteria,2GH3H@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	C	4Fe-4S single cluster domain	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
PYH3_k127_1628218_1	368408.Tpen_0750	2.941e-166	541.0	COG1793@1|root,arCOG01347@2157|Archaea,2XPV8@28889|Crenarchaeota	28889|Crenarchaeota	L	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair	lig	GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016874,GO:0016886,GO:0022616,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360,GO:1901576	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N
PYH3_k127_1628218_3	638303.Thal_0920	1.334e-115	381.0	COG0057@1|root,COG0057@2|Bacteria,2G3TK@200783|Aquificae	200783|Aquificae	C	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	gap	GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
PYH3_k127_1628218_2	1041930.Mtc_0381	6.039e-141	459.0	COG0269@1|root,arCOG00103@2157|Archaea,2XUYW@28890|Euryarchaeota,2N9CN@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin	fae-hps	-	4.1.2.43,4.2.1.147	ko:K13812	ko00030,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00680,map01100,map01120,map01200,map01230	M00345,M00580	R05338,R08058	RC00421,RC00422,RC01583,RC01795	ko00000,ko00001,ko00002,ko01000	-	-	-	Fae,OMPdecase
PYH3_k127_1628218_11	572478.Vdis_1518	1.387e-10	68.0	arCOG05463@1|root,arCOG05463@2157|Archaea,2XSF3@28889|Crenarchaeota	28889|Crenarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_1643785_0	304371.MCP_2305	3.282e-12	73.0	arCOG03727@1|root,arCOG03727@2157|Archaea,2XXUA@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Mrr_cat
PYH3_k127_1643785_1	382464.ABSI01000009_gene3921	0.0002645	52.0	COG1502@1|root,COG1502@2|Bacteria,46X9U@74201|Verrucomicrobia,2IUGR@203494|Verrucomicrobiae	203494|Verrucomicrobiae	I	Phospholipase D Active site motif	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_2
PYH3_k127_1645516_2	287.DR97_1657	2.947e-33	138.0	COG0424@1|root,COG0424@2|Bacteria,1RH6H@1224|Proteobacteria,1S41D@1236|Gammaproteobacteria,1YEU5@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	D	Maf-like protein	yhdE	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0030145,GO:0036218,GO:0036221,GO:0042802,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0047429	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
PYH3_k127_1645516_3	368408.Tpen_0018	1.32e-25	113.0	COG1522@1|root,arCOG01580@2157|Archaea,2XQYS@28889|Crenarchaeota	28889|Crenarchaeota	K	PFAM regulatory protein AsnC Lrp family	-	-	-	ko:K03718	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
PYH3_k127_1645516_1	383372.Rcas_3269	2.623e-45	175.0	COG1058@1|root,COG1058@2|Bacteria,2G6DU@200795|Chloroflexi,374WE@32061|Chloroflexia	2|Bacteria	S	PFAM molybdopterin binding domain	cinA	-	3.5.1.42	ko:K03742	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA,MoCF_biosynth
PYH3_k127_1645516_0	1442599.JAAN01000020_gene2534	6.411e-60	226.0	COG0624@1|root,COG0624@2|Bacteria,1R96A@1224|Proteobacteria,1RSD6@1236|Gammaproteobacteria,1X5K9@135614|Xanthomonadales	135614|Xanthomonadales	E	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
PYH3_k127_1647653_1	324602.Caur_1774	9.33e-70	244.0	COG1132@1|root,COG1132@2|Bacteria,2G7J5@200795|Chloroflexi,3758C@32061|Chloroflexia	32061|Chloroflexia	V	PFAM ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
PYH3_k127_1647653_0	867845.KI911784_gene975	3.637e-93	331.0	COG1132@1|root,COG1132@2|Bacteria,2G63W@200795|Chloroflexi,377YS@32061|Chloroflexia	32061|Chloroflexia	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
PYH3_k127_1678073_2	926550.CLDAP_12770	3.814e-50	184.0	COG0778@1|root,COG0778@2|Bacteria,2G693@200795|Chloroflexi	200795|Chloroflexi	C	PFAM Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
PYH3_k127_1678073_1	357808.RoseRS_1138	2.573e-101	341.0	COG0391@1|root,COG0391@2|Bacteria,2G5S2@200795|Chloroflexi,376XW@32061|Chloroflexia	32061|Chloroflexia	S	TIGRFAM LPPG domain	-	-	2.7.8.28	ko:K11212	ko00680,ko01120,map00680,map01120	M00378	R09398	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	UPF0052
PYH3_k127_1678073_0	523850.TON_0602	3.433e-154	501.0	COG0215@1|root,arCOG00486@2157|Archaea,2XTRY@28890|Euryarchaeota,243CK@183968|Thermococci	183968|Thermococci	J	Cysteinyl-tRNA synthetase	cysS	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e,tRNA-synt_1g
PYH3_k127_1678073_3	339860.Msp_1301	3.445e-38	149.0	COG1208@1|root,arCOG00666@2157|Archaea,2XT8U@28890|Euryarchaeota,23NRH@183925|Methanobacteria	183925|Methanobacteria	M	Bacterial transferase hexapeptide repeat	-	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
PYH3_k127_1709130_1	1304874.JAFY01000002_gene380	6.991e-08	61.0	COG2232@1|root,COG2232@2|Bacteria,3TC66@508458|Synergistetes	508458|Synergistetes	S	ATP-grasp domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_3
PYH3_k127_1709130_2	589924.Ferp_0866	0.000191	50.0	arCOG07522@1|root,arCOG07522@2157|Archaea,2Y1I3@28890|Euryarchaeota,247FV@183980|Archaeoglobi	183980|Archaeoglobi	K	Transcriptional regulator, TrmB	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_1709130_0	1487953.JMKF01000045_gene2940	1.383e-30	132.0	COG0455@1|root,COG0455@2|Bacteria,1G1EJ@1117|Cyanobacteria,1H7J7@1150|Oscillatoriales	1117|Cyanobacteria	D	PFAM CobQ CobB MinD ParA nucleotide binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_31,CbiA,ParA
PYH3_k127_1762474_2	1365176.N186_04385	2.116e-46	175.0	COG0142@1|root,arCOG01726@2157|Archaea,2XPZM@28889|Crenarchaeota	28889|Crenarchaeota	H	Belongs to the FPP GGPP synthase family	fgs	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13787	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
PYH3_k127_1762474_3	98439.AJLL01000007_gene3885	1.492e-31	129.0	COG3793@1|root,COG3793@2|Bacteria,1G6ZI@1117|Cyanobacteria,1JIP1@1189|Stigonemataceae	1117|Cyanobacteria	P	PFAM Mo-dependent nitrogenase	-	-	-	-	-	-	-	-	-	-	-	-	TerB
PYH3_k127_1762474_4	679926.Mpet_1500	6.594e-25	110.0	COG3467@1|root,arCOG00520@2157|Archaea,2XXWD@28890|Euryarchaeota	28890|Euryarchaeota	S	PFAM pyridoxamine 5'-phosphate oxidase-related, FMN-binding	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Pyridox_ox_2
PYH3_k127_1762474_0	1042877.GQS_04270	2.277e-91	317.0	COG0520@1|root,arCOG00065@2157|Archaea,2XSYI@28890|Euryarchaeota,24366@183968|Thermococci	183968|Thermococci	E	Aminotransferase class-V	-	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
PYH3_k127_1762474_1	1459636.NTE_00077	2.574e-66	234.0	COG0476@1|root,COG1977@1|root,arCOG00536@2157|Archaea,arCOG01676@2157|Archaea,41S5X@651137|Thaumarchaeota	651137|Thaumarchaeota	H	ThiF family	-	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF,ThiS
PYH3_k127_1765276_1	909613.UO65_2209	7.473e-08	62.0	COG1011@1|root,COG1011@2|Bacteria,2GNSS@201174|Actinobacteria,4E1I2@85010|Pseudonocardiales	201174|Actinobacteria	S	haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2,Hydrolase
PYH3_k127_1765276_3	1121272.KB903261_gene5930	0.0003593	54.0	COG3227@1|root,COG4447@1|root,COG3227@2|Bacteria,COG4447@2|Bacteria,2I4PF@201174|Actinobacteria,4DC47@85008|Micromonosporales	201174|Actinobacteria	E	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
PYH3_k127_1765276_0	644283.Micau_5580	1.846e-13	80.0	COG1657@1|root,COG1657@2|Bacteria,2IA0T@201174|Actinobacteria,4DB55@85008|Micromonosporales	201174|Actinobacteria	I	PFAM Prenyltransferase squalene oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Prenyltrans
PYH3_k127_1765276_2	1220534.B655_0855	1.234e-06	53.0	COG3371@1|root,arCOG02008@2157|Archaea,2XWKR@28890|Euryarchaeota	28890|Euryarchaeota	S	Protein of unknown function (DUF998)	-	-	-	-	-	-	-	-	-	-	-	-	DUF998
PYH3_k127_1782050_0	266117.Rxyl_0158	7.967e-71	256.0	COG1079@1|root,COG1079@2|Bacteria,2GKMB@201174|Actinobacteria,4CPYV@84995|Rubrobacteria	84995|Rubrobacteria	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
PYH3_k127_178747_0	1459636.NTE_02266	2.789e-76	267.0	COG0008@1|root,arCOG04302@2157|Archaea,41S5V@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
PYH3_k127_1806599_0	593750.Metfor_0945	3.686e-58	226.0	COG0642@1|root,arCOG02348@1|root,arCOG02350@1|root,arCOG02353@1|root,arCOG02385@1|root,arCOG02348@2157|Archaea,arCOG02350@2157|Archaea,arCOG02353@2157|Archaea,arCOG02385@2157|Archaea,arCOG06193@2157|Archaea,2Y7U3@28890|Euryarchaeota,2NAXF@224756|Methanomicrobia	2157|Archaea	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	BAT,GAF_2,HATPase_c,HTH_10,PAS,PAS_3,PAS_4,PAS_9,Response_reg
PYH3_k127_1806599_1	1828.JOKB01000066_gene4741	2.908e-24	113.0	28IVP@1|root,2Z8U1@2|Bacteria,2H4T5@201174|Actinobacteria,4G4JW@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_1823967_3	339860.Msp_1301	8.255e-55	203.0	COG1208@1|root,arCOG00666@2157|Archaea,2XT8U@28890|Euryarchaeota,23NRH@183925|Methanobacteria	183925|Methanobacteria	M	Bacterial transferase hexapeptide repeat	-	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
PYH3_k127_1823967_1	662479.C440_04713	2.082e-82	291.0	COG1109@1|root,arCOG00767@2157|Archaea,2XT1X@28890|Euryarchaeota,23SSW@183963|Halobacteria	183963|Halobacteria	G	Belongs to the phosphohexose mutase family	pmm1	-	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
PYH3_k127_1823967_2	387631.Asulf_00240	1.213e-78	280.0	COG1109@1|root,arCOG00767@2157|Archaea,2XT1X@28890|Euryarchaeota,246NW@183980|Archaeoglobi	183980|Archaeoglobi	G	Belongs to the phosphohexose mutase family	-	-	5.4.2.2,5.4.2.8	ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
PYH3_k127_1823967_0	420247.Msm_0648	4.237e-104	353.0	COG1109@1|root,arCOG00767@2157|Archaea,2XT1X@28890|Euryarchaeota,23NW7@183925|Methanobacteria	183925|Methanobacteria	G	Belongs to the phosphohexose mutase family	glmM2	-	5.4.2.2,5.4.2.8	ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
PYH3_k127_1908791_0	272844.PAB1312	7.728e-108	370.0	COG1061@1|root,arCOG00874@2157|Archaea,2XTYQ@28890|Euryarchaeota,243Y9@183968|Thermococci	183968|Thermococci	K	ERCC3/RAD25/XPB C-terminal helicase	-	-	-	-	-	-	-	-	-	-	-	-	ERCC3_RAD25_C,ResIII
PYH3_k127_1908791_1	1278073.MYSTI_00634	2.013e-05	55.0	COG1502@1|root,COG1502@2|Bacteria,1NZKD@1224|Proteobacteria,430D2@68525|delta/epsilon subdivisions,2WVTD@28221|Deltaproteobacteria,2YV79@29|Myxococcales	28221|Deltaproteobacteria	I	PLD-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_2
PYH3_k127_1926978_2	471852.Tcur_1136	3.982e-06	53.0	COG1522@1|root,COG1522@2|Bacteria,2GN6I@201174|Actinobacteria,4EJT4@85012|Streptosporangiales	201174|Actinobacteria	K	helix_turn_helix ASNC type	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_AsnC-type
PYH3_k127_1926978_1	529709.PYCH_13110	8.347e-08	62.0	COG0640@1|root,arCOG01683@2157|Archaea,2Y3PS@28890|Euryarchaeota,243P1@183968|Thermococci	183968|Thermococci	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
PYH3_k127_1926978_0	529818.AMSG_10388T0	5.217e-19	101.0	COG1100@1|root,KOG0395@2759|Eukaryota	2759|Eukaryota	G	GTPase activity	cpras1	-	-	ko:K07208	ko04072,ko04140,ko04150,ko04151,ko04152,ko04211,ko04218,ko04714,ko04910,ko04919,ko05165,ko05231,map04072,map04140,map04150,map04151,map04152,map04211,map04218,map04714,map04910,map04919,map05165,map05231	-	-	-	ko00000,ko00001,ko04031	-	-	-	PH,Ras
PYH3_k127_1937932_2	335543.Sfum_0998	2.395e-44	164.0	COG2110@1|root,COG2110@2|Bacteria,1RCWP@1224|Proteobacteria,42RVP@68525|delta/epsilon subdivisions,2WNCX@28221|Deltaproteobacteria,2MQI0@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Appr-1'-p processing enzyme	ymdB	-	-	-	-	-	-	-	-	-	-	-	Macro
PYH3_k127_1937932_1	1121430.JMLG01000008_gene1569	3.562e-99	355.0	COG1239@1|root,COG1239@2|Bacteria,1UHYK@1239|Firmicutes,24BJ0@186801|Clostridia,2609Y@186807|Peptococcaceae	186801|Clostridia	H	PFAM magnesium chelatase	-	-	6.6.1.1	ko:K03404,ko:K03405	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03877	RC01012	ko00000,ko00001,ko01000	-	-	-	AAA_5,Mg_chelatase,VWA_2
PYH3_k127_1937932_3	484019.THA_1287	6.901e-05	54.0	COG2374@1|root,COG4085@1|root,COG2374@2|Bacteria,COG4085@2|Bacteria,2GCXZ@200918|Thermotogae	200918|Thermotogae	S	Endonuclease Exonuclease Phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux
PYH3_k127_1937932_0	593117.TGAM_1722	4.645e-109	364.0	COG0464@1|root,arCOG01308@2157|Archaea,2XSYR@28890|Euryarchaeota,243CC@183968|Thermococci	183968|Thermococci	D	Cell division protein 48 (CDC48) N-terminal domain	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N,Vps4_C
PYH3_k127_2026741_0	1382356.JQMP01000004_gene339	8.965e-78	270.0	COG0648@1|root,COG0648@2|Bacteria,2G5XZ@200795|Chloroflexi,27XEG@189775|Thermomicrobia	189775|Thermomicrobia	L	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin	nfo	-	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
PYH3_k127_2026741_2	1094980.Mpsy_1830	4.803e-42	173.0	COG1030@1|root,arCOG01910@2157|Archaea,2XW1R@28890|Euryarchaeota,2NAHP@224756|Methanomicrobia	224756|Methanomicrobia	O	Clp protease	-	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	CLP_protease,NfeD
PYH3_k127_2026741_1	485916.Dtox_1353	3.542e-66	247.0	COG1148@1|root,COG1148@2|Bacteria,1V5YJ@1239|Firmicutes,248CC@186801|Clostridia,260ZH@186807|Peptococcaceae	186801|Clostridia	C	binding domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Pyr_redox_2
PYH3_k127_2075815_0	1227495.C487_06028	0.0001373	48.0	arCOG02989@1|root,arCOG02989@2157|Archaea,2Y00B@28890|Euryarchaeota,23XHN@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_2123650_7	439235.Dalk_3208	2.088e-08	65.0	2DMZP@1|root,32UMQ@2|Bacteria,1N3K9@1224|Proteobacteria,42UFA@68525|delta/epsilon subdivisions,2WQ9Z@28221|Deltaproteobacteria,2MNTS@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF3795)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3795
PYH3_k127_2123650_2	880072.Desac_1897	1.626e-76	272.0	COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,42NM8@68525|delta/epsilon subdivisions,2WIWB@28221|Deltaproteobacteria,2MRBG@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Belongs to the Glu Leu Phe Val dehydrogenases family	-	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
PYH3_k127_2123650_5	555088.DealDRAFT_2904	1.635e-14	82.0	COG2119@1|root,COG2119@2|Bacteria	2|Bacteria	O	membrane	-	-	-	-	-	-	-	-	-	-	-	-	UPF0016
PYH3_k127_2123650_6	1341151.ASZU01000026_gene1166	9.111e-09	67.0	COG0454@1|root,COG0456@2|Bacteria,1TS4G@1239|Firmicutes,4HFDG@91061|Bacilli	91061|Bacilli	K	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
PYH3_k127_2123650_0	673860.AciM339_1556	3.698e-117	390.0	COG0535@1|root,arCOG00938@2157|Archaea,2XUDB@28890|Euryarchaeota,3F2ZN@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	4Fe-4S single cluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM
PYH3_k127_2123650_1	644966.Tmar_0298	2.146e-106	358.0	COG0006@1|root,COG0006@2|Bacteria,1UY7B@1239|Firmicutes,24E77@186801|Clostridia	186801|Clostridia	E	Creatinase/Prolidase N-terminal domain	-	-	3.5.3.3	ko:K08688	ko00260,ko00330,ko01100,map00260,map00330,map01100	-	R01566	RC00548,RC00549	ko00000,ko00001,ko01000	-	-	-	Creatinase_N,Peptidase_M24
PYH3_k127_2123650_4	1121472.AQWN01000004_gene877	9.377e-46	175.0	COG1751@1|root,COG1751@2|Bacteria,1V1CN@1239|Firmicutes,24G0M@186801|Clostridia,261NK@186807|Peptococcaceae	186801|Clostridia	S	PFAM Pyruvate kinase, alpha beta domain	-	-	-	ko:K09126	-	-	-	-	ko00000	-	-	-	PK_C
PYH3_k127_2123650_3	926550.CLDAP_20570	1.326e-46	176.0	COG3634@1|root,COG3634@2|Bacteria,2G6SQ@200795|Chloroflexi	200795|Chloroflexi	O	TIGRFAM glutaredoxin-like domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_3
PYH3_k127_2152237_7	1459636.NTE_02170	6.198e-05	49.0	COG5431@1|root,arCOG01120@2157|Archaea,41SW3@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_2152237_0	634497.HAH_1744	1.515e-198	652.0	COG1201@1|root,arCOG00557@2157|Archaea,2XSTH@28890|Euryarchaeota,23S50@183963|Halobacteria	183963|Halobacteria	K	DEAD H associated	lhr1	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
PYH3_k127_2152237_3	1033806.HTIA_2003	7.748e-37	158.0	COG1599@1|root,arCOG01510@2157|Archaea,2XTJP@28890|Euryarchaeota,23U8X@183963|Halobacteria	183963|Halobacteria	L	COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins	rpa2	-	-	ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko03000,ko03032,ko03400	-	-	-	REPA_OB_2,tRNA_anti-codon
PYH3_k127_2152237_4	572478.Vdis_0767	1.48e-13	73.0	COG4888@1|root,arCOG04136@2157|Archaea,2XRI7@28889|Crenarchaeota	28889|Crenarchaeota	J	Transcription elongation factor Elf1 like	-	-	-	-	-	-	-	-	-	-	-	-	Elf1
PYH3_k127_2152237_2	868131.MSWAN_0178	2.709e-43	167.0	COG0463@1|root,arCOG00896@2157|Archaea,2XT4C@28890|Euryarchaeota,23PWV@183925|Methanobacteria	183925|Methanobacteria	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
PYH3_k127_2152237_6	391623.TERMP_00330	4.464e-07	62.0	arCOG01312@1|root,arCOG03256@1|root,arCOG03400@1|root,arCOG01312@2157|Archaea,arCOG03256@2157|Archaea,arCOG03400@2157|Archaea,2Y7MH@28890|Euryarchaeota,243S6@183968|Thermococci	183968|Thermococci	L	ABC-type uncharacterized transport system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux
PYH3_k127_2152237_5	529709.PYCH_06130	6.28e-10	68.0	COG0170@1|root,arCOG01880@2157|Archaea,2XXY5@28890|Euryarchaeota,2439Q@183968|Thermococci	183968|Thermococci	I	PFAM phosphatidate cytidylyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_2152237_1	1343739.PAP_00020	9.598e-145	476.0	COG1372@1|root,COG1933@1|root,arCOG03145@2157|Archaea,arCOG04447@2157|Archaea,2XU5S@28890|Euryarchaeota,24309@183968|Thermococci	183968|Thermococci	L	Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase	polC	GO:0003674,GO:0005488,GO:0005515,GO:0042802	2.7.7.7	ko:K02322	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	M00264	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	Intein_splicing,LAGLIDADG_3,PolC_DP2
PYH3_k127_2188990_1	1365176.N186_06370	1.007e-26	117.0	COG1618@1|root,arCOG01034@2157|Archaea,2XR6D@28889|Crenarchaeota	28889|Crenarchaeota	F	Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency	-	-	3.6.1.15	ko:K06928	ko00230,ko00730,ko01100,map00230,map00730,map01100	-	R00086,R00615	RC00002	ko00000,ko00001,ko01000	-	-	-	NTPase_1
PYH3_k127_2188990_0	342949.PNA2_1273	8.6e-87	299.0	COG0072@1|root,arCOG00412@2157|Archaea,2XTD5@28890|Euryarchaeota,242YE@183968|Thermococci	183968|Thermococci	J	Phenylalanyl-tRNA synthetase beta subunit	pheT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,tRNA-synt_2d
PYH3_k127_2270628_1	439481.Aboo_0779	2.011e-19	102.0	COG4870@1|root,arCOG02501@1|root,arCOG03439@1|root,arCOG02501@2157|Archaea,arCOG03439@2157|Archaea,arCOG03607@2157|Archaea	2157|Archaea	O	Papain family cysteine protease	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Big_3_3,Big_3_5,NosD,PKD,Peptidase_C1,S_layer_C
PYH3_k127_2270628_0	4513.MLOC_398.2	1.597e-58	207.0	COG4354@1|root,KOG2119@2759|Eukaryota,37JKE@33090|Viridiplantae,3GG94@35493|Streptophyta,3M3G6@4447|Liliopsida,3ITAX@38820|Poales	35493|Streptophyta	G	Non-lysosomal glucosylceramidase that catalyzes the conversion of glucosylceramide to free glucose and ceramide	-	GO:0003674,GO:0003824,GO:0004553,GO:0005575,GO:0006082,GO:0006629,GO:0007275,GO:0007399,GO:0007417,GO:0008150,GO:0008152,GO:0008202,GO:0008206,GO:0008422,GO:0009056,GO:0009987,GO:0015926,GO:0016020,GO:0016021,GO:0016137,GO:0016139,GO:0016787,GO:0016798,GO:0019752,GO:0021953,GO:0021954,GO:0022008,GO:0030154,GO:0030182,GO:0031224,GO:0032501,GO:0032502,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0048468,GO:0048666,GO:0048699,GO:0048731,GO:0048856,GO:0048869,GO:0071704,GO:1901135,GO:1901136,GO:1901360,GO:1901575,GO:1901615,GO:1901657,GO:1901658	3.2.1.45	ko:K17108	ko00511,ko00600,ko01100,map00511,map00600,map01100	-	R01498	RC00059,RC00451	ko00000,ko00001,ko01000	-	GH116	-	DUF608,Glyco_hydr_116N
PYH3_k127_2317121_7	530564.Psta_1240	2.826e-18	98.0	COG3503@1|root,COG3503@2|Bacteria	2|Bacteria	J	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF1624
PYH3_k127_2317121_1	498761.HM1_1600	1.983e-117	400.0	COG0469@1|root,COG0469@2|Bacteria,1TPGG@1239|Firmicutes,2489V@186801|Clostridia	186801|Clostridia	G	Belongs to the pyruvate kinase family	pyk	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PEP-utilizers,PK,PK_C
PYH3_k127_2317121_4	1121085.AUCI01000045_gene70	2.179e-58	216.0	COG1788@1|root,COG1788@2|Bacteria,1UYH2@1239|Firmicutes,4HGBM@91061|Bacilli,1ZIHE@1386|Bacillus	91061|Bacilli	I	Coenzyme A transferase	-	-	2.8.3.12	ko:K01039	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
PYH3_k127_2317121_2	1125863.JAFN01000001_gene1335	4.058e-65	231.0	COG2057@1|root,COG2057@2|Bacteria,1MY3S@1224|Proteobacteria,42R4B@68525|delta/epsilon subdivisions,2WMZN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	PFAM Coenzyme A transferase	-	-	2.8.3.12	ko:K01040	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
PYH3_k127_2317121_5	673860.AciM339_1091	1.999e-44	165.0	COG0432@1|root,arCOG04214@2157|Archaea,2XYW0@28890|Euryarchaeota,3F3BR@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
PYH3_k127_2317121_6	195522.BD01_0445	9.418e-19	97.0	COG0697@1|root,arCOG00272@2157|Archaea,2XZ49@28890|Euryarchaeota,242N7@183968|Thermococci	183968|Thermococci	G	EamA-like transporter family	-	-	-	ko:K03298	-	-	-	-	ko00000,ko02000	2.A.7.3	-	-	EamA
PYH3_k127_2317121_0	693661.Arcve_0786	6.749e-130	428.0	COG1850@1|root,arCOG04443@2157|Archaea,2XVBP@28890|Euryarchaeota,245T4@183980|Archaeoglobi	183980|Archaeoglobi	G	Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase	rbcL	-	4.1.1.39	ko:K01601	ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200	M00165,M00166,M00532	R00024,R03140	RC00172,RC00859	ko00000,ko00001,ko00002,ko01000	-	-	-	RuBisCO_large,RuBisCO_large_N
PYH3_k127_2317121_3	1220534.B655_1877	2.892e-60	216.0	COG1415@1|root,arCOG04253@2157|Archaea,2XU0W@28890|Euryarchaeota,23PHY@183925|Methanobacteria	183925|Methanobacteria	S	Protein of unknown function (DUF763)	-	-	-	ko:K09003	-	-	-	-	ko00000	-	-	-	DUF763
PYH3_k127_2434446_0	304371.MCP_0813	1.156e-98	347.0	COG1193@1|root,arCOG02895@2157|Archaea,2XT51@28890|Euryarchaeota,2N90Z@224756|Methanomicrobia	224756|Methanomicrobia	L	Has ATPase and non-specific DNA-binding activities	mutS2	-	-	ko:K07456	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	HHH_5,MutS_V
PYH3_k127_2434446_2	342949.PNA2_1095	1.548e-40	155.0	COG1056@1|root,arCOG00972@2157|Archaea,2XUF7@28890|Euryarchaeota,242MG@183968|Thermococci	183968|Thermococci	F	nicotinamide-nucleotide adenylyltransferase activity	-	-	2.7.7.1	ko:K00952	ko00760,ko01100,map00760,map01100	-	R00137,R03005	RC00002	ko00000,ko00001,ko01000	-	-	-	CTP_transf_like
PYH3_k127_2434446_3	272557.APE_0959	1.245e-14	81.0	COG0350@1|root,arCOG02724@2157|Archaea,2XR5F@28889|Crenarchaeota	28889|Crenarchaeota	L	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated	ogt	-	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1
PYH3_k127_2434446_1	384616.Pisl_0753	1.533e-70	248.0	COG0430@1|root,arCOG04125@2157|Archaea,2XPT6@28889|Crenarchaeota	28889|Crenarchaeota	J	Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP	rtcA	GO:0003674,GO:0003824,GO:0003963,GO:0009975,GO:0016874,GO:0016886,GO:0140098	6.5.1.4	ko:K01974	-	-	-	-	ko00000,ko01000	-	-	-	RTC,RTC_insert
PYH3_k127_2526096_4	1459636.NTE_02598	0.000946	44.0	COG0704@1|root,arCOG00318@2157|Archaea,41T1H@651137|Thaumarchaeota	651137|Thaumarchaeota	P	Phosphate uptake regulator	-	-	-	-	-	-	-	-	-	-	-	-	PhoU
PYH3_k127_2526096_1	1094980.Mpsy_1726	1.656e-87	308.0	COG1311@1|root,arCOG04455@2157|Archaea,2XSUG@28890|Euryarchaeota,2N96N@224756|Methanomicrobia	224756|Methanomicrobia	L	Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase	polB	-	2.7.7.7	ko:K02323	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	M00264	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	DNA_pol_E_B,Metallophos,tRNA_anti-codon
PYH3_k127_2526096_3	1365176.N186_01615	2.274e-07	60.0	COG1801@1|root,arCOG04291@2157|Archaea	2157|Archaea	L	DUF72 domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
PYH3_k127_2526096_0	1042877.GQS_07195	2.986e-129	426.0	COG1474@1|root,arCOG00467@2157|Archaea,2XU73@28890|Euryarchaeota,242PQ@183968|Thermococci	183968|Thermococci	L	Involved in regulation of DNA replication	cdc6	-	-	ko:K10725	-	-	-	-	ko00000,ko03032	-	-	-	AAA,AAA_16,Cdc6_C
PYH3_k127_2526096_2	1041930.Mtc_1493	4.476e-11	70.0	arCOG04038@1|root,arCOG04038@2157|Archaea,2Y5TS@28890|Euryarchaeota,2NBDA@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_2534269_1	69014.TK2281	4.085e-70	248.0	COG1131@1|root,arCOG00194@2157|Archaea,2XT7Q@28890|Euryarchaeota,243M3@183968|Thermococci	183968|Thermococci	E	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
PYH3_k127_2534269_0	673860.AciM339_1311	5.012e-76	279.0	COG0747@1|root,arCOG01534@2157|Archaea,2XTPJ@28890|Euryarchaeota,3F353@33867|unclassified Euryarchaeota	28890|Euryarchaeota	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
PYH3_k127_257416_0	1192034.CAP_4608	2.987e-65	229.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42MK5@68525|delta/epsilon subdivisions,2WJ3Z@28221|Deltaproteobacteria,2YUET@29|Myxococcales	28221|Deltaproteobacteria	C	Acyl-CoA dehydrogenase, N-terminal domain	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
PYH3_k127_257416_3	747365.Thena_1023	1.337e-05	58.0	COG1297@1|root,COG1297@2|Bacteria,1TQJP@1239|Firmicutes,247JY@186801|Clostridia,42F20@68295|Thermoanaerobacterales	186801|Clostridia	S	oligopeptide transporter, OPT family	-	-	-	-	-	-	-	-	-	-	-	-	OPT
PYH3_k127_257416_1	439235.Dalk_4975	1.321e-19	94.0	COG1433@1|root,COG1433@2|Bacteria,1N8RP@1224|Proteobacteria,42W3C@68525|delta/epsilon subdivisions,2WRJB@28221|Deltaproteobacteria,2MKUU@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Putative redox-active protein (C_GCAxxG_C_C)	-	-	-	-	-	-	-	-	-	-	-	-	C_GCAxxG_C_C
PYH3_k127_257416_2	1184251.TCELL_1055	1.068e-14	83.0	COG0747@1|root,arCOG01534@2157|Archaea,2XQ84@28889|Crenarchaeota	28889|Crenarchaeota	E	PFAM extracellular solute-binding protein, family 5	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
PYH3_k127_2622336_1	591019.Shell_0397	8.8e-06	57.0	COG3371@1|root,arCOG02008@2157|Archaea,2XQVC@28889|Crenarchaeota	28889|Crenarchaeota	S	Protein of unknown function (DUF998)	-	-	-	-	-	-	-	-	-	-	-	-	DUF998
PYH3_k127_2622336_0	593750.Metfor_1983	5.318e-44	170.0	COG1418@1|root,arCOG01860@2157|Archaea,2XSXG@28890|Euryarchaeota,2NA06@224756|Methanomicrobia	224756|Methanomicrobia	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K06950	-	-	-	-	ko00000	-	-	-	HD
PYH3_k127_2627767_3	104355.XP_007863219.1	9.544e-35	141.0	KOG0094@1|root,KOG0094@2759|Eukaryota,38CQH@33154|Opisthokonta,3NYN5@4751|Fungi,3UZPE@5204|Basidiomycota,227YG@155619|Agaricomycetes,3H0WG@355688|Agaricomycetes incertae sedis	4751|Fungi	U	GTP binding protein	ryh1	GO:0000045,GO:0000166,GO:0000301,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005794,GO:0005801,GO:0005829,GO:0006810,GO:0006890,GO:0006891,GO:0006914,GO:0006996,GO:0007033,GO:0007154,GO:0007165,GO:0007264,GO:0008104,GO:0008150,GO:0008152,GO:0009056,GO:0009966,GO:0009967,GO:0009987,GO:0010646,GO:0010647,GO:0012505,GO:0016043,GO:0016192,GO:0016197,GO:0016236,GO:0016462,GO:0016482,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0022607,GO:0023051,GO:0023052,GO:0023056,GO:0031503,GO:0032006,GO:0032008,GO:0032258,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0033036,GO:0033365,GO:0034497,GO:0034613,GO:0034629,GO:0035556,GO:0035639,GO:0036094,GO:0042147,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044085,GO:0044237,GO:0044248,GO:0044422,GO:0044424,GO:0044431,GO:0044444,GO:0044446,GO:0044464,GO:0046907,GO:0048193,GO:0048518,GO:0048522,GO:0048583,GO:0048584,GO:0050789,GO:0050794,GO:0050896,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0051716,GO:0061919,GO:0065007,GO:0070727,GO:0070925,GO:0071840,GO:0072665,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1902531,GO:1902533,GO:1903939,GO:1904515,GO:1905037	-	ko:K07893	-	-	-	-	ko00000,ko04031,ko04131,ko04147	-	-	-	Ras
PYH3_k127_2627767_1	439235.Dalk_4525	2.521e-135	442.0	COG1748@1|root,COG1748@2|Bacteria,1NIU2@1224|Proteobacteria,42MHS@68525|delta/epsilon subdivisions,2WJQW@28221|Deltaproteobacteria,2MHRC@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Saccharopine dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP
PYH3_k127_2627767_0	378806.STAUR_3080	1.079e-183	591.0	COG1070@1|root,COG1070@2|Bacteria,1MW4A@1224|Proteobacteria,42Q1B@68525|delta/epsilon subdivisions,2WKJH@28221|Deltaproteobacteria,2YU85@29|Myxococcales	28221|Deltaproteobacteria	G	FGGY family of carbohydrate kinases, N-terminal domain	-	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
PYH3_k127_2627767_2	552811.Dehly_0088	1.593e-52	198.0	COG1230@1|root,COG1230@2|Bacteria,2G6FI@200795|Chloroflexi,34D5R@301297|Dehalococcoidia	301297|Dehalococcoidia	P	Cation efflux family	-	-	-	ko:K16264	-	-	-	-	ko00000,ko02000	2.A.4.1	-	-	Cation_efflux
PYH3_k127_2627767_4	1042209.HK44_006850	0.0002003	45.0	COG1028@1|root,COG1028@2|Bacteria,1MXNQ@1224|Proteobacteria,1S0NX@1236|Gammaproteobacteria,1YNT1@136843|Pseudomonas fluorescens group	1224|Proteobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
PYH3_k127_2671095_2	1123035.ARLA01000023_gene1174	2.236e-11	75.0	COG3420@1|root,COG3420@2|Bacteria,4NEGT@976|Bacteroidetes,1HXK5@117743|Flavobacteriia,4C2U1@83612|Psychroflexus	976|Bacteroidetes	P	Periplasmic copper-binding protein (NosD)	nosD	-	-	ko:K07218	-	-	-	-	ko00000	-	-	-	NosD
PYH3_k127_2671095_1	192952.MM_3136	2.613e-49	185.0	COG0842@1|root,arCOG01467@2157|Archaea,2XU41@28890|Euryarchaeota,2N9R3@224756|Methanomicrobia	224756|Methanomicrobia	V	TIGRFAM daunorubicin resistance ABC transporter, inner membrane subunit B	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
PYH3_k127_2671095_0	368407.Memar_0328	8.447e-100	339.0	COG1131@1|root,arCOG00194@2157|Archaea,2XUK9@28890|Euryarchaeota,2N95K@224756|Methanomicrobia	224756|Methanomicrobia	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
PYH3_k127_2828380_2	671143.DAMO_0460	4.753e-46	179.0	COG2218@1|root,COG2218@2|Bacteria	2|Bacteria	C	formylmethanofuran dehydrogenase activity	fhcC	GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0044237,GO:0044281	1.2.7.12	ko:K00202	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060,R11743	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	GXGXG
PYH3_k127_2828380_0	387631.Asulf_01966	7.227e-82	286.0	COG3252@1|root,arCOG02675@2157|Archaea,2XUB2@28890|Euryarchaeota,2460U@183980|Archaeoglobi	183980|Archaeoglobi	H	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT	mch	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	3.5.4.27	ko:K01499	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03464	RC01870	ko00000,ko00001,ko00002,ko01000	-	-	-	MCH
PYH3_k127_2828380_1	368407.Memar_2381	4.816e-55	203.0	arCOG03714@1|root,arCOG07526@1|root,arCOG03714@2157|Archaea,arCOG07526@2157|Archaea,2XXQF@28890|Euryarchaeota	28890|Euryarchaeota	FV	Restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	ATP-cone,Mrr_cat
PYH3_k127_2828380_3	1236689.MMALV_07510	1.845e-30	126.0	COG1602@1|root,arCOG04269@2157|Archaea,2XTEQ@28890|Euryarchaeota,3F34R@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Archaeal Nre, N-terminal	nreA	-	-	-	-	-	-	-	-	-	-	-	Nre_C,Nre_N
PYH3_k127_2865208_0	1282876.BAOK01000001_gene2666	1.171e-167	547.0	COG2730@1|root,COG2730@2|Bacteria,1R5YR@1224|Proteobacteria,2U55F@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Cellulase (glycosyl hydrolase family 5)	-	-	-	-	-	-	-	-	-	-	-	-	Cellulase
PYH3_k127_2875116_1	1094980.Mpsy_2622	7.893e-58	211.0	COG2144@1|root,arCOG00640@2157|Archaea,2XTU9@28890|Euryarchaeota,2N979@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM AIR synthase related protein	-	-	-	ko:K07123	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
PYH3_k127_2875116_0	269799.Gmet_3037	4.157e-63	225.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,42P96@68525|delta/epsilon subdivisions,2WMVB@28221|Deltaproteobacteria,43TUK@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
PYH3_k127_2875116_4	258533.BN977_05276	1.5e-07	65.0	COG0577@1|root,COG0577@2|Bacteria,2HPS0@201174|Actinobacteria,236G0@1762|Mycobacteriaceae	201174|Actinobacteria	V	ABC transporter (permease)	-	-	-	-	-	-	-	-	-	-	-	-	FtsX
PYH3_k127_2875116_2	521460.Athe_0111	2.506e-54	203.0	COG1136@1|root,COG1136@2|Bacteria,1TP6H@1239|Firmicutes,247JJ@186801|Clostridia	186801|Clostridia	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
PYH3_k127_2875116_3	511051.CSE_09390	5.552e-17	83.0	2C539@1|root,33HA4@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_297560_0	374847.Kcr_0279	6.077e-133	444.0	COG1793@1|root,arCOG01347@2157|Archaea	2157|Archaea	F	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair	lig	GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016874,GO:0016886,GO:0022616,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360,GO:1901576	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N
PYH3_k127_297560_3	666510.ASAC_0962	9.701e-18	88.0	COG1599@1|root,arCOG01510@2157|Archaea,2XQQM@28889|Crenarchaeota	28889|Crenarchaeota	L	PFAM nucleic acid binding, OB-fold, tRNA helicase-type	-	-	-	ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko03000,ko03032,ko03400	-	-	-	tRNA_anti-codon
PYH3_k127_297560_2	374847.Kcr_0126	2.052e-24	112.0	COG0586@1|root,arCOG03117@2157|Archaea	2157|Archaea	S	membrane-associated protein	-	-	-	ko:K03975	-	-	-	-	ko00000	-	-	-	SNARE_assoc
PYH3_k127_297560_1	186497.PF1781	9.449e-55	199.0	COG0164@1|root,arCOG04121@2157|Archaea,2XWYC@28890|Euryarchaeota,242VW@183968|Thermococci	183968|Thermococci	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
PYH3_k127_2987801_0	1382359.JIAL01000001_gene2735	3.117e-177	585.0	COG0383@1|root,COG0383@2|Bacteria,3Y3ID@57723|Acidobacteria,2JINT@204432|Acidobacteriia	204432|Acidobacteriia	G	Glycosyl hydrolase 38 domain protein	-	-	3.2.1.24	ko:K01191	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04131	-	GH38	-	Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C
PYH3_k127_2987801_1	402881.Plav_0833	1.108e-44	165.0	COG2730@1|root,COG2730@2|Bacteria,1R5YR@1224|Proteobacteria,2U55F@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Cellulase (glycosyl hydrolase family 5)	-	-	-	-	-	-	-	-	-	-	-	-	Cellulase
PYH3_k127_300844_0	523850.TON_0030	1.739e-83	284.0	COG0689@1|root,arCOG01575@2157|Archaea,2XVHI@28890|Euryarchaeota,242PZ@183968|Thermococci	183968|Thermococci	J	Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'- 5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails	rrp41	GO:0000177,GO:0000178,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575,GO:1902494,GO:1905354	-	ko:K11600	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	RNase_PH,RNase_PH_C
PYH3_k127_300844_2	1220534.B655_1252	4.603e-64	226.0	COG1097@1|root,arCOG00678@2157|Archaea,2XWEN@28890|Euryarchaeota,23P36@183925|Methanobacteria	183925|Methanobacteria	J	Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome	rrp4	-	-	ko:K03679	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	ECR1_N,KH_6
PYH3_k127_300844_1	694440.JOMF01000005_gene118	4.368e-66	234.0	COG1500@1|root,arCOG04187@2157|Archaea,2XTNH@28890|Euryarchaeota,2N9D8@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM Shwachman-Bodian-Diamond syndrome	-	-	-	ko:K14574	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	SBDS,SBDS_C
PYH3_k127_300844_3	644281.MFS40622_1571	5.958e-52	192.0	COG0638@1|root,arCOG00971@2157|Archaea,2XUKA@28890|Euryarchaeota,23QEI@183939|Methanococci	183939|Methanococci	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	psmA	GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0019538,GO:0019773,GO:0030163,GO:0032991,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03432	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome,Proteasome_A_N
PYH3_k127_3031808_3	926561.KB900622_gene618	9.356e-08	60.0	COG0778@1|root,COG0778@2|Bacteria,1UW3S@1239|Firmicutes,25M99@186801|Clostridia,3WC8N@53433|Halanaerobiales	186801|Clostridia	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
PYH3_k127_3031808_2	1049564.TevJSym_ak00210	2.267e-34	136.0	COG1765@1|root,COG1765@2|Bacteria,1N1RR@1224|Proteobacteria,1S3KI@1236|Gammaproteobacteria,1J71R@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
PYH3_k127_3031808_1	1211819.CALK01000029_gene2010	1.043e-75	267.0	COG1453@1|root,COG1453@2|Bacteria,1TPBG@1239|Firmicutes,3VQ2E@526524|Erysipelotrichia	526524|Erysipelotrichia	S	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red,Fer4_17
PYH3_k127_3031808_0	926550.CLDAP_15660	1.925e-151	500.0	COG0318@1|root,COG0318@2|Bacteria,2G5Q8@200795|Chloroflexi	200795|Chloroflexi	IQ	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
PYH3_k127_3039153_2	386456.JQKN01000011_gene795	8.548e-24	107.0	COG0640@1|root,arCOG00731@2157|Archaea,2XYSK@28890|Euryarchaeota	2157|Archaea	K	transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
PYH3_k127_3039153_3	1259795.ARJK01000002_gene340	1.741e-19	102.0	2CFYQ@1|root,348K6@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_3039153_0	399550.Smar_1443	7.567e-95	319.0	COG1013@1|root,arCOG01599@2157|Archaea,2XPQG@28889|Crenarchaeota	28889|Crenarchaeota	C	TIGRFAM pyruvate ferredoxin flavodoxin oxidoreductase, beta subunit	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFO_beta_C,TPP_enzyme_C
PYH3_k127_3039153_1	1009370.ALO_13409	1.994e-88	302.0	COG0674@1|root,COG0674@2|Bacteria,1TSSC@1239|Firmicutes,4H3ES@909932|Negativicutes	909932|Negativicutes	C	2-oxoacid acceptor oxidoreductase, alpha subunit	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
PYH3_k127_3074472_0	448385.sce4940	4.945e-26	125.0	COG1409@1|root,COG2133@1|root,COG5563@1|root,COG1409@2|Bacteria,COG2133@2|Bacteria,COG5563@2|Bacteria,1NS3S@1224|Proteobacteria,43AFC@68525|delta/epsilon subdivisions,2X64J@28221|Deltaproteobacteria,2Z0UN@29|Myxococcales	28221|Deltaproteobacteria	G	Purple acid Phosphatase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Pur_ac_phosph_N
PYH3_k127_3074472_1	1151117.AJLF01000001_gene1134	9.448e-15	85.0	COG4945@1|root,arCOG01310@2157|Archaea,2Y7ME@28890|Euryarchaeota,243B5@183968|Thermococci	2157|Archaea	G	to be involved in regulation of amylopullulanase-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Glucodextran_C,PEGA
PYH3_k127_3159389_4	1227487.C474_05595	2.915e-67	250.0	COG3276@1|root,arCOG01562@2157|Archaea,2XTHU@28890|Euryarchaeota,23SK9@183963|Halobacteria	183963|Halobacteria	J	protein synthesis factor GTP-binding	gbp2	-	-	ko:K03231	ko03013,ko05134,map03013,map05134	-	-	-	ko00000,ko00001,ko03012,ko03016,ko03019,ko04131,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
PYH3_k127_3159389_5	195522.BD01_1282	3.375e-17	91.0	COG0463@1|root,arCOG00896@2157|Archaea,2Y7MP@28890|Euryarchaeota,242VC@183968|Thermococci	183968|Thermococci	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,HAD_2
PYH3_k127_3159389_1	368408.Tpen_0002	1.53e-120	400.0	COG1363@1|root,arCOG01518@2157|Archaea,2XPWC@28889|Crenarchaeota	28889|Crenarchaeota	G	peptidase M42 family protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M42
PYH3_k127_3159389_3	699248.SRA_05446	6.866e-74	263.0	COG0274@1|root,COG0274@2|Bacteria,1TPAJ@1239|Firmicutes,4HAAJ@91061|Bacilli	91061|Bacilli	F	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate	deoC	GO:0003674,GO:0003824,GO:0004139,GO:0005975,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009262,GO:0009264,GO:0009987,GO:0016052,GO:0016829,GO:0016830,GO:0016832,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	4.1.2.4	ko:K01619	ko00030,map00030	-	R01066	RC00436,RC00437	ko00000,ko00001,ko01000	-	-	iSB619.SA_RS00835	DeoC
PYH3_k127_3159389_0	443254.Marpi_1140	2.119e-182	591.0	COG2414@1|root,COG2414@2|Bacteria,2GCI5@200918|Thermotogae	200918|Thermotogae	C	PFAM Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
PYH3_k127_3159389_6	356851.JOAN01000005_gene91	1.686e-12	76.0	COG0671@1|root,COG0671@2|Bacteria,2I92V@201174|Actinobacteria,4DE1M@85008|Micromonosporales	201174|Actinobacteria	I	phosphoesterase, PA-phosphatase related	-	-	-	-	-	-	-	-	-	-	-	-	PAP2
PYH3_k127_3159389_2	269797.Mbar_A0543	7.355e-119	390.0	COG0143@1|root,arCOG00810@2157|Archaea,2XTG5@28890|Euryarchaeota,2N99D@224756|Methanomicrobia	224756|Methanomicrobia	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF692.Mbar_A0543	Anticodon_1,tRNA-synt_1g,tRNA_bind
PYH3_k127_316331_1	351160.RRC262	4.899e-98	331.0	COG1229@1|root,arCOG04461@2157|Archaea,2XV5V@28890|Euryarchaeota,2N9G0@224756|Methanomicrobia	224756|Methanomicrobia	C	Formylmethanofuran dehydrogenase subunit A	fmdA	-	1.2.7.12	ko:K00200	ko00680,ko01100,ko01120,ko01130,ko01200,map00680,map01100,map01120,map01130,map01200	M00567	R03015,R08060	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_3
PYH3_k127_316331_4	1082932.ATCR1_15416	2.584e-21	105.0	COG0454@1|root,COG0454@2|Bacteria,1QU4I@1224|Proteobacteria,2TU4A@28211|Alphaproteobacteria,4B93P@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
PYH3_k127_316331_5	374847.Kcr_0356	3.419e-09	69.0	arCOG05346@1|root,arCOG05346@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_316331_3	1191523.MROS_1829	1.437e-64	233.0	COG1181@1|root,COG1181@2|Bacteria	2|Bacteria	F	Belongs to the D-alanine--D-alanine ligase family	ddlA	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
PYH3_k127_316331_2	1121904.ARBP01000003_gene6365	9.903e-73	260.0	COG0498@1|root,COG0498@2|Bacteria,4NKWI@976|Bacteroidetes,47SIW@768503|Cytophagia	976|Bacteroidetes	E	Pyridoxal-phosphate dependent enzyme	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	LeuA_dimer,PALP
PYH3_k127_316331_0	1410653.JHVC01000001_gene1596	2.953e-122	404.0	COG2217@1|root,COG2217@2|Bacteria,1TP5S@1239|Firmicutes,247MW@186801|Clostridia,36DJE@31979|Clostridiaceae	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
PYH3_k127_3178857_2	368407.Memar_1722	3.239e-25	107.0	COG4294@1|root,arCOG01898@2157|Archaea,2XVT2@28890|Euryarchaeota	28890|Euryarchaeota	L	UV-endonuclease UvdE	uvsE	-	-	ko:K13281	-	-	-	-	ko00000,ko01000	-	-	-	UvdE
PYH3_k127_3178857_4	404380.Gbem_3607	7e-08	63.0	COG0716@1|root,COG0716@2|Bacteria,1QXNN@1224|Proteobacteria,43C4J@68525|delta/epsilon subdivisions,2X7F0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Flavodoxin	-	-	1.6.5.2	ko:K03809	ko00130,ko01110,map00130,map01110	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	Flavodoxin_5
PYH3_k127_3178857_0	985053.VMUT_1375	7.28e-110	368.0	COG1250@1|root,arCOG00249@2157|Archaea,2XPQ7@28889|Crenarchaeota	28889|Crenarchaeota	I	3-hydroxyacyl-CoA dehydrogenase	-	-	1.1.1.35,4.2.1.17	ko:K15016	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00374,M00375	R01975,R03026	RC00117,RC00831	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
PYH3_k127_3178857_3	1280390.CBQR020000097_gene2196	2.082e-09	67.0	2E6H4@1|root,3314B@2|Bacteria,1VW5U@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_3178857_1	1121373.KB903654_gene1663	5.242e-46	173.0	COG4430@1|root,COG4430@2|Bacteria,4NN4Z@976|Bacteroidetes,47PX0@768503|Cytophagia	976|Bacteroidetes	S	Bacteriocin-protection, YdeI or OmpD-Associated	-	-	-	-	-	-	-	-	-	-	-	-	OmdA
PYH3_k127_323819_0	309798.COPRO5265_0285	2.657e-60	215.0	COG1116@1|root,COG1116@2|Bacteria,1TT4F@1239|Firmicutes,24FTR@186801|Clostridia,42GE7@68295|Thermoanaerobacterales	186801|Clostridia	P	PFAM ABC transporter related	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
PYH3_k127_323819_1	224325.AF_0578	3.166e-57	219.0	COG2234@1|root,arCOG02962@2157|Archaea	2157|Archaea	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
PYH3_k127_323819_2	479433.Caci_4742	2.218e-08	63.0	COG4325@1|root,COG4325@2|Bacteria,2IK41@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_3298372_6	1121918.ARWE01000001_gene3094	1.875e-10	64.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42MK5@68525|delta/epsilon subdivisions,2WJ3Z@28221|Deltaproteobacteria,43T7N@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
PYH3_k127_3298372_2	42256.RradSPS_1663	1.508e-44	182.0	COG1012@1|root,COG1012@2|Bacteria,2H1UT@201174|Actinobacteria,4CSB5@84995|Rubrobacteria	84995|Rubrobacteria	C	Aldehyde dehydrogenase family	-	-	1.2.1.16,1.2.1.20,1.2.1.79	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	M00027	R00713,R00714,R02401	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
PYH3_k127_3298372_3	690850.Desaf_0912	2.302e-40	165.0	COG0644@1|root,COG0644@2|Bacteria,1MXQY@1224|Proteobacteria,42UR3@68525|delta/epsilon subdivisions,2WQQQ@28221|Deltaproteobacteria,2M7TS@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	TIGRFAM geranylgeranyl reductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
PYH3_k127_3298372_0	574087.Acear_1487	1.798e-135	454.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,3WBG8@53433|Halanaerobiales	186801|Clostridia	C	PFAM Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738,ko:K19515	ko00030,ko00362,ko01100,ko01120,ko01200,map00030,map00362,map01100,map01120,map01200	M00309,M00541	R08571,R10961	RC00242,RC01839	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
PYH3_k127_3298372_4	335541.Swol_1704	9.091e-36	143.0	COG1142@1|root,COG1142@2|Bacteria,1UHYS@1239|Firmicutes,24JZC@186801|Clostridia,42KMI@68298|Syntrophomonadaceae	186801|Clostridia	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_11,Fer4_3,Fer4_4,Fer4_6
PYH3_k127_3298372_5	5722.XP_001584373.1	1.903e-28	124.0	KOG0084@1|root,KOG0084@2759|Eukaryota	2759|Eukaryota	S	GTPase activity	-	-	-	ko:K07874	ko05134,map05134	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	Ras
PYH3_k127_3298372_1	1042877.GQS_10700	2.218e-77	269.0	COG0017@1|root,arCOG00407@2157|Archaea,2XTZJ@28890|Euryarchaeota,242NW@183968|Thermococci	183968|Thermococci	J	Belongs to the class-II aminoacyl-tRNA synthetase family	asnS	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.1.1.22	ko:K01893	ko00970,map00970	M00359,M00360	R03648	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
PYH3_k127_3350960_0	391623.TERMP_01190	6.235e-135	454.0	COG1178@1|root,arCOG00163@2157|Archaea,2XUE2@28890|Euryarchaeota,242Z4@183968|Thermococci	183968|Thermococci	P	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
PYH3_k127_3350960_1	335543.Sfum_3496	8.299e-97	332.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,42MUK@68525|delta/epsilon subdivisions,2X5CN@28221|Deltaproteobacteria,2MRN0@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	TOBE domain	-	-	3.6.3.30	ko:K02010	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10	-	-	ABC_tran,TOBE_2
PYH3_k127_3350960_2	309800.C498_10916	1.432e-07	59.0	arCOG07300@1|root,arCOG07300@2157|Archaea,2XXYB@28890|Euryarchaeota,23WG9@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_3388653_1	1519464.HY22_01920	3.812e-40	156.0	COG0265@1|root,COG0265@2|Bacteria	2|Bacteria	O	serine-type endopeptidase activity	MA20_17565	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
PYH3_k127_3388653_0	926692.AZYG01000064_gene985	1.139e-40	166.0	COG1533@1|root,COG1533@2|Bacteria,1TSS2@1239|Firmicutes,248SB@186801|Clostridia	186801|Clostridia	L	Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
PYH3_k127_3388653_2	99598.Cal7507_4682	1.433e-29	122.0	COG1714@1|root,COG1714@2|Bacteria	2|Bacteria	S	RDD family	yxaI	-	-	-	-	-	-	-	-	-	-	-	DUF4339,Pkinase,RDD
PYH3_k127_3399772_0	648996.Theam_1479	9.761e-136	441.0	COG1260@1|root,COG1260@2|Bacteria,2G3U0@200783|Aquificae	200783|Aquificae	I	Myo-inositol-1-phosphate synthase	-	-	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth
PYH3_k127_3399772_2	399550.Smar_0879	1.44e-11	67.0	COG3609@1|root,arCOG01009@2157|Archaea,2XR62@28889|Crenarchaeota	28889|Crenarchaeota	K	PFAM CopG domain protein DNA-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1
PYH3_k127_3399772_1	1041930.Mtc_0977	1.18e-49	180.0	COG1964@1|root,arCOG00933@2157|Archaea,2XTMK@28890|Euryarchaeota,2N91G@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM Radical SAM domain protein	-	-	-	ko:K06937	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Fer4_14,Radical_SAM
PYH3_k127_3401708_0	1041930.Mtc_1660	8.755e-91	308.0	COG0265@1|root,arCOG02833@2157|Archaea,2XT7Y@28890|Euryarchaeota,2NAWS@224756|Methanomicrobia	224756|Methanomicrobia	O	Trypsin	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
PYH3_k127_3401708_2	763034.HMPREF9446_02861	4.945e-06	58.0	COG1266@1|root,COG1266@2|Bacteria,4NHRW@976|Bacteroidetes,2FNU0@200643|Bacteroidia,4AN86@815|Bacteroidaceae	976|Bacteroidetes	S	CAAX amino terminal protease family	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
PYH3_k127_3401708_1	926550.CLDAP_35280	2.408e-47	180.0	COG0454@1|root,COG0456@2|Bacteria,2G91C@200795|Chloroflexi	200795|Chloroflexi	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
PYH3_k127_3401708_3	351160.RCIX2275	0.0001658	50.0	COG1413@1|root,arCOG02966@2157|Archaea,2XSWS@28890|Euryarchaeota	28890|Euryarchaeota	C	PBS lyase	cpcE2	-	-	ko:K22221	-	-	-	-	ko00000	-	-	-	HEAT_2,HEAT_PBS
PYH3_k127_3406376_0	368408.Tpen_0679	5.137e-157	505.0	COG0464@1|root,arCOG01308@2157|Archaea,2XPXJ@28889|Crenarchaeota	28889|Crenarchaeota	O	Cell division protein 48 (CDC48), domain 2	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N,Vps4_C
PYH3_k127_3473029_1	1459636.NTE_02598	3.416e-28	126.0	COG0704@1|root,arCOG00318@2157|Archaea,41T1H@651137|Thaumarchaeota	651137|Thaumarchaeota	P	Phosphate uptake regulator	-	-	-	-	-	-	-	-	-	-	-	-	PhoU
PYH3_k127_3473029_0	374847.Kcr_1472	4.066e-77	267.0	COG0714@1|root,arCOG00441@2157|Archaea	2157|Archaea	V	ATPase associated with various cellular activities, AAA_5	gvpN	-	-	ko:K03924,ko:K04748	-	-	R00294	RC02794	ko00000,ko01000	3.D.4.10	-	-	AAA_5,CbbQ_C,HHH_5
PYH3_k127_3494931_0	399550.Smar_0856	4.489e-69	242.0	COG0638@1|root,arCOG00971@2157|Archaea,2XQ8X@28889|Crenarchaeota	28889|Crenarchaeota	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	psmA	GO:0000502,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0019773,GO:0032991,GO:0044424,GO:0044464,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03432	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome,Proteasome_A_N
PYH3_k127_3494931_1	419665.Maeo_0221	3.816e-34	143.0	COG1432@1|root,arCOG02408@2157|Archaea,2XX7V@28890|Euryarchaeota,23QBQ@183939|Methanococci	183939|Methanococci	S	NYN domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN
PYH3_k127_3519979_8	1131266.ARWQ01000018_gene768	2.387e-05	48.0	COG1818@1|root,arCOG00084@2157|Archaea,41SNW@651137|Thaumarchaeota	651137|Thaumarchaeota	S	THUMP domain	-	-	-	ko:K06963	-	-	-	-	ko00000,ko03016	-	-	-	THUMP
PYH3_k127_3519979_7	1070774.J07HN4v3_02973	5.429e-09	65.0	COG1617@1|root,arCOG02197@2157|Archaea,2XXRY@28890|Euryarchaeota,23W8H@183963|Halobacteria	183963|Halobacteria	S	KEOPS complex Cgi121-like subunit	cgi121	-	-	ko:K09119	-	-	-	-	ko00000,ko03016	-	-	-	CGI-121
PYH3_k127_3519979_3	266117.Rxyl_0226	2.725e-30	130.0	COG0619@1|root,COG0619@2|Bacteria,2GUVM@201174|Actinobacteria	201174|Actinobacteria	P	Cobalt transport protein	-	-	-	ko:K16785	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	CbiQ
PYH3_k127_3519979_1	1365176.N186_04920	9.303e-74	262.0	COG1122@1|root,arCOG00202@2157|Archaea	2157|Archaea	P	ABC-type cobalt transport system ATPase component	cbiO	-	-	ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran
PYH3_k127_3519979_2	485916.Dtox_1967	1.347e-67	239.0	COG0488@1|root,COG0488@2|Bacteria,1UI2R@1239|Firmicutes,25EBF@186801|Clostridia,267CI@186807|Peptococcaceae	186801|Clostridia	S	PFAM ABC transporter related	-	-	-	ko:K16785,ko:K16786,ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran
PYH3_k127_3519979_4	342949.PNA2_1162	3.16e-28	127.0	COG0618@1|root,arCOG01565@2157|Archaea,2XWQV@28890|Euryarchaeota,2433D@183968|Thermococci	183968|Thermococci	S	DHH family	-	-	-	-	-	-	-	-	-	-	-	-	DHH,DHHA1
PYH3_k127_3519979_6	521011.Mpal_2110	3.953e-10	66.0	COG1382@1|root,arCOG01342@2157|Archaea,2XX88@28890|Euryarchaeota,2N9TP@224756|Methanomicrobia	224756|Methanomicrobia	O	Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding	pfdB	-	-	ko:K04798	-	-	-	-	ko00000,ko03110	-	-	-	Prefoldin_2
PYH3_k127_3519979_9	653948.CCA15655	0.0002462	50.0	COG2136@1|root,KOG2781@2759|Eukaryota	2759|Eukaryota	AJ	rRNA primary transcript binding	IMP4	GO:0001650,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005730,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0019843,GO:0022613,GO:0030515,GO:0030684,GO:0030686,GO:0031974,GO:0031981,GO:0032040,GO:0032991,GO:0034457,GO:0034470,GO:0034641,GO:0034660,GO:0042134,GO:0042162,GO:0042254,GO:0042274,GO:0043047,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043565,GO:0044085,GO:0044237,GO:0044238,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044452,GO:0044464,GO:0046483,GO:0070013,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0098847,GO:1901360,GO:1901363,GO:1990904	-	ko:K14561	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	Brix
PYH3_k127_3519979_5	186497.PF2008	5.921e-23	101.0	COG1997@1|root,arCOG04208@2157|Archaea,2XYWD@28890|Euryarchaeota,244K8@183968|Thermococci	183968|Thermococci	J	binds to the 23S rRNA	rpl37ae	-	-	ko:K02921	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L37ae
PYH3_k127_3519979_0	195522.BD01_2094	1.941e-75	261.0	COG2123@1|root,arCOG01574@2157|Archaea,2XWTK@28890|Euryarchaeota,2433E@183968|Thermococci	183968|Thermococci	J	Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site	rrp42	GO:0000177,GO:0000178,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0017091,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1902494,GO:1905354	-	ko:K12589	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	RNase_PH,RNase_PH_C
PYH3_k127_3539858_1	1382306.JNIM01000001_gene2680	2.802e-28	119.0	COG0720@1|root,COG0720@2|Bacteria,2G919@200795|Chloroflexi	200795|Chloroflexi	H	6-pyruvoyl tetrahydropterin synthase	-	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
PYH3_k127_3539858_0	673860.AciM339_1242	3.29e-205	653.0	COG0459@1|root,arCOG01257@2157|Archaea,2XUDQ@28890|Euryarchaeota,3F2WH@33867|unclassified Euryarchaeota	28890|Euryarchaeota	O	TCP-1/cpn60 chaperonin family	thsA	GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0044183,GO:0051082,GO:0061077	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
PYH3_k127_3539858_3	717606.PaecuDRAFT_2857	2.641e-06	51.0	COG0403@1|root,COG0403@2|Bacteria,1TQGG@1239|Firmicutes,4HA7P@91061|Bacilli,26RS0@186822|Paenibacillaceae	91061|Bacilli	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPA	-	1.4.4.2	ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
PYH3_k127_3658268_3	323259.Mhun_2940	1.582e-05	54.0	COG0468@1|root,arCOG00415@2157|Archaea,2XT80@28890|Euryarchaeota,2N980@224756|Methanomicrobia	224756|Methanomicrobia	L	Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules	radA	-	-	ko:K04483	-	-	-	-	ko00000,ko03400	-	-	-	HHH_5,Rad51
PYH3_k127_3658268_0	278957.ABEA03000186_gene1540	5.475e-108	367.0	COG0277@1|root,COG0277@2|Bacteria,46Y87@74201|Verrucomicrobia,3K93M@414999|Opitutae	414999|Opitutae	C	FAD linked oxidases, C-terminal domain	-	-	2.5.1.26	ko:K00803	ko00565,ko01100,ko04146,map00565,map01100,map04146	-	R04311	RC00020,RC02886	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
PYH3_k127_3658268_1	644968.DFW101_1142	4.827e-56	211.0	COG0247@1|root,COG0247@2|Bacteria,1MUMH@1224|Proteobacteria,42R1T@68525|delta/epsilon subdivisions,2WN88@28221|Deltaproteobacteria,2ME8R@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	1.8.98.1	ko:K08264	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	-	R04540	RC00011	ko00000,ko00001,ko01000	-	-	-	CCG,Fer4_8
PYH3_k127_3658268_2	309801.trd_1042	6.932e-41	161.0	COG2120@1|root,COG2120@2|Bacteria,2G6FB@200795|Chloroflexi,27XV7@189775|Thermomicrobia	189775|Thermomicrobia	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
PYH3_k127_3697104_3	765911.Thivi_3054	5.183e-05	54.0	COG1198@1|root,COG1198@2|Bacteria,1QU4F@1224|Proteobacteria,1T59I@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_3697104_2	1132509.C447_09647	9.352e-14	83.0	COG1524@1|root,arCOG01378@2157|Archaea,2XVGR@28890|Euryarchaeota,23SZJ@183963|Halobacteria	183963|Halobacteria	S	type I phosphodiesterase nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
PYH3_k127_3697104_1	1151117.AJLF01000001_gene1528	3.198e-31	130.0	COG0716@1|root,arCOG00519@2157|Archaea,2XZ4A@28890|Euryarchaeota,24470@183968|Thermococci	183968|Thermococci	C	Flavodoxin	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_4
PYH3_k127_3697104_0	660470.Theba_1788	1.565e-56	213.0	COG2407@1|root,COG2407@2|Bacteria,2GC41@200918|Thermotogae	200918|Thermotogae	G	L-fucose isomerase	-	-	5.3.1.25,5.3.1.3	ko:K01818	ko00051,ko01120,map00051,map01120	-	R03163	RC00434	ko00000,ko00001,ko01000	-	-	-	Fucose_iso_C,Fucose_iso_N1,Fucose_iso_N2
PYH3_k127_3719095_0	391623.TERMP_00675	8.169e-99	331.0	COG1245@1|root,arCOG00187@2157|Archaea,2XSZE@28890|Euryarchaeota,242JH@183968|Thermococci	183968|Thermococci	E	Possible Fer4-like domain in RNase L inhibitor, RLI	-	-	-	ko:K06174	-	-	-	-	ko00000,ko03009	-	-	-	ABC_tran,Fer4,RLI
PYH3_k127_3719095_2	1220534.B655_0360	5.828e-42	166.0	COG1578@1|root,arCOG04410@2157|Archaea,2XWGU@28890|Euryarchaeota,23NZ1@183925|Methanobacteria	183925|Methanobacteria	S	Protein of unknown function DUF89	-	-	-	ko:K09116	-	-	-	-	ko00000	-	-	-	DUF89
PYH3_k127_3719095_1	1382304.JNIL01000001_gene226	5.297e-49	189.0	COG0006@1|root,COG0006@2|Bacteria,1TQ44@1239|Firmicutes,4HAT7@91061|Bacilli,27894@186823|Alicyclobacillaceae	91061|Bacilli	E	Creatinase/Prolidase N-terminal domain	pepP	-	3.4.11.9,3.4.13.9	ko:K01262,ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
PYH3_k127_3775728_0	643648.Slip_2076	1.28e-169	547.0	COG0493@1|root,COG0493@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,42KA9@68298|Syntrophomonadaceae	186801|Clostridia	C	FAD-dependent pyridine nucleotide-disulphide oxidoreductase	gltA	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
PYH3_k127_3775728_1	1163730.FFONT_0226	1.955e-136	455.0	COG2414@1|root,arCOG00706@2157|Archaea,2XQ6E@28889|Crenarchaeota	28889|Crenarchaeota	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
PYH3_k127_3775728_7	401526.TcarDRAFT_0265	9.745e-50	185.0	COG0235@1|root,COG0235@2|Bacteria,1TPDV@1239|Firmicutes,4H46K@909932|Negativicutes	909932|Negativicutes	G	Class II aldolase adducin family protein	-	-	4.1.2.17	ko:K01628	ko00051,ko01120,map00051,map01120	-	R02262	RC00603,RC00604	ko00000,ko00001,ko01000	-	-	-	Aldolase_II
PYH3_k127_3775728_4	557599.MKAN_03715	8.555e-84	297.0	COG0111@1|root,COG0235@1|root,COG1070@1|root,COG0111@2|Bacteria,COG0235@2|Bacteria,COG1070@2|Bacteria,2GIZV@201174|Actinobacteria,23EW1@1762|Mycobacteriaceae	201174|Actinobacteria	EGH	D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain	-	-	1.1.1.399,1.1.1.95,2.7.1.189	ko:K00058,ko:K11216	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,ko02024,map00260,map00680,map01100,map01120,map01130,map01200,map01230,map02024	M00020	R01513,R11183	RC00002,RC00017,RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,Aldolase_II,SCP2
PYH3_k127_3775728_6	557599.MKAN_03715	1.001e-65	237.0	COG0111@1|root,COG0235@1|root,COG1070@1|root,COG0111@2|Bacteria,COG0235@2|Bacteria,COG1070@2|Bacteria,2GIZV@201174|Actinobacteria,23EW1@1762|Mycobacteriaceae	201174|Actinobacteria	EGH	D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain	-	-	1.1.1.399,1.1.1.95,2.7.1.189	ko:K00058,ko:K11216	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,ko02024,map00260,map00680,map01100,map01120,map01130,map01200,map01230,map02024	M00020	R01513,R11183	RC00002,RC00017,RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,Aldolase_II,SCP2
PYH3_k127_3775728_8	1089549.AZUQ01000001_gene2505	1.446e-08	60.0	COG3255@1|root,COG3255@2|Bacteria,2IM6I@201174|Actinobacteria,4EYT8@85014|Glycomycetales	201174|Actinobacteria	I	SCP-2 sterol transfer family	-	-	-	-	-	-	-	-	-	-	-	-	SCP2
PYH3_k127_3775728_2	1122947.FR7_2489	2.688e-101	337.0	COG0543@1|root,COG0543@2|Bacteria,1TP6D@1239|Firmicutes,4H2FP@909932|Negativicutes	909932|Negativicutes	C	PFAM oxidoreductase FAD NAD(P)-binding domain protein	pyrK_1	-	1.18.1.2,1.19.1.1	ko:K00528	-	-	R10159	-	ko00000,ko01000	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
PYH3_k127_3775728_3	1121472.AQWN01000002_gene2216	1.775e-97	344.0	COG1948@1|root,COG4880@2|Bacteria,1TQK0@1239|Firmicutes,247VC@186801|Clostridia,25ZZT@186807|Peptococcaceae	186801|Clostridia	L	Secreted protein with C-terminal beta-propeller domain	-	-	-	-	-	-	-	-	-	-	-	-	Beta_propel
PYH3_k127_3775728_5	633148.Tagg_0886	1.137e-70	261.0	COG0286@1|root,arCOG02632@2157|Archaea,2XREZ@28889|Crenarchaeota	28889|Crenarchaeota	V	PFAM N-6 DNA methylase	-	-	2.1.1.72	ko:K03427,ko:K07317	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_Mtase
PYH3_k127_3784139_1	649638.Trad_1166	5.314e-37	151.0	COG1030@1|root,COG1030@2|Bacteria,1WKAY@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_3784139_0	330779.Saci_0986	3.288e-87	306.0	COG0644@1|root,arCOG00570@2157|Archaea,2XPWV@28889|Crenarchaeota	28889|Crenarchaeota	C	TIGRFAM geranylgeranyl reductase	-	-	1.3.1.101,1.3.7.11	ko:K17830	ko00564,map00564	-	R10325,R10326,R10331	RC03134	ko00000,ko00001,ko01000	-	-	-	DAO,FAD_binding_2,FAD_binding_3,FAD_oxidored,Trp_halogenase
PYH3_k127_3795966_0	1131266.ARWQ01000006_gene220	1.275e-39	157.0	COG1938@1|root,arCOG00347@2157|Archaea,41SSA@651137|Thaumarchaeota	651137|Thaumarchaeota	S	PAC2 family	-	-	-	ko:K06869	-	-	-	-	ko00000	-	-	-	PAC2
PYH3_k127_3795966_5	694429.Pyrfu_0202	1.737e-06	56.0	COG1594@1|root,arCOG00580@2157|Archaea	2157|Archaea	K	DNA-directed RNA polymerase, M 15 kDa subunit	-	-	-	ko:K03057	ko01100,map01100	-	-	-	br01611,ko00000,ko03021	-	-	-	RNA_POL_M_15KD
PYH3_k127_3795966_1	555079.Toce_1991	1.248e-36	147.0	COG1180@1|root,COG1180@2|Bacteria,1V1GP@1239|Firmicutes,24G76@186801|Clostridia,42G5Q@68295|Thermoanaerobacterales	186801|Clostridia	O	TIGRFAM anaerobic ribonucleoside-triphosphate reductase activating protein	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Fer4_14,Radical_SAM
PYH3_k127_3795966_2	5911.EAR85334	5.58e-22	105.0	COG1100@1|root,KOG0087@2759|Eukaryota,3ZDVJ@5878|Ciliophora	5878|Ciliophora	U	Rab subfamily of small GTPases	-	-	-	ko:K07904	ko04144,ko04961,ko04962,ko04972,map04144,map04961,map04962,map04972	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	Ras
PYH3_k127_3795966_6	1499967.BAYZ01000062_gene6036	2.876e-06	61.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria	2|Bacteria	S	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,TPR_12,TPR_16,TPR_7,TPR_8
PYH3_k127_3795966_4	1242864.D187_000360	1.659e-06	62.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,1MWRF@1224|Proteobacteria,42P9S@68525|delta/epsilon subdivisions,2WJI7@28221|Deltaproteobacteria,2YTSQ@29|Myxococcales	28221|Deltaproteobacteria	H	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,TPR_10,TPR_12,TPR_7,TPR_8
PYH3_k127_3795966_3	797114.C475_12345	1.283e-12	73.0	COG1266@1|root,arCOG02766@2157|Archaea,2Y839@28890|Euryarchaeota,23X08@183963|Halobacteria	183963|Halobacteria	S	metal-dependent membrane protease	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
PYH3_k127_3862132_2	512565.AMIS_62390	7.607e-06	58.0	COG2223@1|root,COG2223@2|Bacteria,2I4E5@201174|Actinobacteria,4DMMM@85008|Micromonosporales	201174|Actinobacteria	P	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
PYH3_k127_3862132_0	545697.HMPREF0216_00098	2.053e-129	443.0	COG1233@1|root,COG1233@2|Bacteria,1TS4A@1239|Firmicutes,249K1@186801|Clostridia,36EIK@31979|Clostridiaceae	186801|Clostridia	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
PYH3_k127_3862132_1	368407.Memar_1722	3.918e-113	375.0	COG4294@1|root,arCOG01898@2157|Archaea,2XVT2@28890|Euryarchaeota	28890|Euryarchaeota	L	UV-endonuclease UvdE	uvsE	-	-	ko:K13281	-	-	-	-	ko00000,ko01000	-	-	-	UvdE
PYH3_k127_3875420_1	1041930.Mtc_0044	1.084e-55	205.0	COG0535@1|root,arCOG00941@2157|Archaea,2Y8D6@28890|Euryarchaeota,2NBHW@224756|Methanomicrobia	224756|Methanomicrobia	S	Iron-sulfur cluster-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM,SPASM
PYH3_k127_3875420_2	246194.CHY_2084	8.739e-22	107.0	COG1387@1|root,COG1387@2|Bacteria,1UZ0M@1239|Firmicutes,24FSN@186801|Clostridia,42FB9@68295|Thermoanaerobacterales	186801|Clostridia	E	TIGRFAM histidinol phosphate phosphatase HisJ	hisJ	-	3.1.3.15	ko:K04486	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03013	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PHP,PHP_C
PYH3_k127_3875420_3	1449065.JMLL01000014_gene3302	0.0007022	50.0	COG0467@1|root,COG0467@2|Bacteria,1NEWW@1224|Proteobacteria,2TRTV@28211|Alphaproteobacteria,43H8V@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	T	KaiC	kaiC	-	-	ko:K08482	-	-	-	-	ko00000	-	-	-	ATPase
PYH3_k127_3875420_0	342949.PNA2_1148	2.847e-74	262.0	COG1363@1|root,arCOG01519@2157|Archaea,2XTBH@28890|Euryarchaeota,2432Z@183968|Thermococci	183968|Thermococci	G	M42 glutamyl aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M42
PYH3_k127_3875876_2	867903.ThesuDRAFT_00680	3.694e-30	126.0	COG0576@1|root,COG0576@2|Bacteria,1V6G2@1239|Firmicutes,24MQK@186801|Clostridia,3WCM6@538999|Clostridiales incertae sedis	186801|Clostridia	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
PYH3_k127_3875876_0	247490.KSU1_C1370	1.422e-246	777.0	COG0443@1|root,COG0443@2|Bacteria,2IWWS@203682|Planctomycetes	203682|Planctomycetes	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
PYH3_k127_3875876_1	1041930.Mtc_1153	8.953e-113	375.0	COG0484@1|root,arCOG02846@2157|Archaea,2XV5D@28890|Euryarchaeota,2N95Q@224756|Methanomicrobia	224756|Methanomicrobia	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
PYH3_k127_3875876_3	673860.AciM339_0344	2.054e-17	85.0	COG0312@1|root,arCOG00322@2157|Archaea,2XV41@28890|Euryarchaeota,3F31M@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
PYH3_k127_3908931_0	453591.Igni_1374	2.077e-105	355.0	COG3635@1|root,arCOG01696@2157|Archaea,2XPTU@28889|Crenarchaeota	28889|Crenarchaeota	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	apgM	-	5.4.2.12	ko:K15635	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,PhosphMutase
PYH3_k127_4087749_0	1385935.N836_25315	1.165e-40	164.0	COG3173@1|root,COG3173@2|Bacteria,1G9K4@1117|Cyanobacteria	1117|Cyanobacteria	S	Phosphotransferase enzyme family	-	-	2.7.1.190	ko:K17910	-	-	R11229	RC00002,RC00078	ko00000,ko01000,ko01504	-	-	-	APH
PYH3_k127_4093990_11	109760.SPPG_05221T0	3.183e-18	87.0	KOG4115@1|root,KOG4115@2759|Eukaryota,3A3F9@33154|Opisthokonta,3P6RS@4751|Fungi	4751|Fungi	DN	Dynein light chain	-	-	-	ko:K10419	-	-	-	-	ko00000,ko04131,ko04812	-	-	-	Robl_LC7
PYH3_k127_4093990_12	644281.MFS40622_0222	2.132e-12	74.0	COG2018@1|root,arCOG02603@2157|Archaea,2XY6Z@28890|Euryarchaeota,23R2D@183939|Methanococci	183939|Methanococci	S	PFAM Roadblock LC7 family protein	-	-	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
PYH3_k127_4093990_6	670487.Ocepr_1644	6.448e-34	138.0	COG1100@1|root,COG1100@2|Bacteria,1WJAD@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	PFAM ADP-ribosylation factor family	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	Arf
PYH3_k127_4093990_13	118168.MC7420_6236	3.076e-12	72.0	COG2018@1|root,COG2018@2|Bacteria,1G7A5@1117|Cyanobacteria,1HBQ8@1150|Oscillatoriales	1117|Cyanobacteria	S	Roadblock LC7 domain	-	-	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
PYH3_k127_4093990_0	868131.MSWAN_0483	9.542e-89	299.0	COG0020@1|root,arCOG01532@2157|Archaea,2XSW1@28890|Euryarchaeota,23NKV@183925|Methanobacteria	183925|Methanobacteria	H	Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids	uppS	-	2.5.1.89	ko:K15888	ko00900,map00900	-	R09730	RC00279,RC02839	ko00000,ko00001,ko01000	-	-	-	Prenyltransf
PYH3_k127_4093990_10	1343739.PAP_00805	2.318e-21	98.0	COG1432@1|root,arCOG02408@2157|Archaea,2XX7V@28890|Euryarchaeota,24419@183968|Thermococci	183968|Thermococci	S	NYN domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN
PYH3_k127_4093990_9	1343739.PAP_09275	2.094e-21	104.0	COG1340@1|root,arCOG01159@2157|Archaea,2XU21@28890|Euryarchaeota,242V1@183968|Thermococci	183968|Thermococci	S	archaeal coiled-coil protein	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_4093990_2	246969.TAM4_2077	5.54e-79	270.0	COG1042@1|root,arCOG01338@2157|Archaea,2XXCA@28890|Euryarchaeota,2435P@183968|Thermococci	183968|Thermococci	C	ATP-grasp domain	-	-	6.2.1.13	ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5
PYH3_k127_4093990_4	673860.AciM339_1496	3.948e-61	220.0	COG1100@1|root,arCOG01225@2157|Archaea,2XWN4@28890|Euryarchaeota,3F2J6@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Conserved hypothetical ATP binding protein	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	ATP_bind_1
PYH3_k127_4093990_3	1343739.PAP_09615	1.17e-70	247.0	COG1709@1|root,arCOG04060@2157|Archaea,2XT58@28890|Euryarchaeota,243MS@183968|Thermococci	183968|Thermococci	K	Helix-turn-helix domain	-	-	-	ko:K07731	-	-	-	-	ko00000,ko03000	-	-	-	HTH_19,HTH_3
PYH3_k127_4093990_8	63737.Npun_R5014	3.838e-22	108.0	COG0170@1|root,COG0170@2|Bacteria,1GJ5N@1117|Cyanobacteria,1HMBV@1161|Nostocales	1117|Cyanobacteria	I	PFAM phosphatidate cytidylyltransferase	-	-	2.7.1.182	ko:K18678	-	-	R10659	RC00002,RC00017	ko00000,ko01000	-	-	-	-
PYH3_k127_4093990_7	868131.MSWAN_0405	3.315e-24	109.0	COG1418@1|root,arCOG01858@2157|Archaea,2XY7Y@28890|Euryarchaeota,23PK9@183925|Methanobacteria	183925|Methanobacteria	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K06950	-	-	-	-	ko00000	-	-	-	HD
PYH3_k127_4093990_5	589924.Ferp_0592	1.484e-56	217.0	COG0433@1|root,arCOG00280@2157|Archaea,2Y7MA@28890|Euryarchaeota,246V1@183980|Archaeoglobi	183980|Archaeoglobi	L	AAA-like domain	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF87,HAS-barrel
PYH3_k127_4093990_1	351160.RCIX379	4.293e-83	291.0	COG0060@1|root,arCOG00807@2157|Archaea,2XTIX@28890|Euryarchaeota,2N9A3@224756|Methanomicrobia	224756|Methanomicrobia	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
PYH3_k127_4109574_3	986075.CathTA2_2337	9.422e-15	78.0	COG3255@1|root,COG3255@2|Bacteria,1VFEY@1239|Firmicutes,4HNS7@91061|Bacilli	91061|Bacilli	I	Sterol carrier protein	-	-	-	-	-	-	-	-	-	-	-	-	SCP2
PYH3_k127_4109574_1	234267.Acid_2435	1.013e-85	300.0	COG0160@1|root,COG0160@2|Bacteria,3Y3P2@57723|Acidobacteria	57723|Acidobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.19,2.6.1.22	ko:K00823,ko:K07250	ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648,R04188	RC00006,RC00062,RC00160	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
PYH3_k127_4109574_4	1463821.JOGR01000001_gene1235	5.657e-13	81.0	COG0382@1|root,COG0382@2|Bacteria,2IJV5@201174|Actinobacteria	201174|Actinobacteria	H	UbiA prenyltransferase family	-	-	2.5.1.133,2.5.1.62	ko:K04040	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R06284,R09067,R11514,R11517	RC00020	ko00000,ko00001,ko01000,ko01006	-	-	-	UbiA
PYH3_k127_4109574_2	186497.PF1921	1.531e-34	140.0	COG0560@1|root,arCOG01158@2157|Archaea,2XT0C@28890|Euryarchaeota,242US@183968|Thermococci	183968|Thermococci	E	phosphoserine phosphatase	-	-	3.1.3.3	ko:K01079	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R00582	RC00017	ko00000,ko00001,ko00002,ko01000,ko01009	-	-	-	HAD
PYH3_k127_4109574_0	555088.DealDRAFT_0500	5.783e-130	436.0	COG1001@1|root,COG1001@2|Bacteria,1TP84@1239|Firmicutes,247KN@186801|Clostridia	186801|Clostridia	F	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family	ade	-	3.5.4.2	ko:K01486	ko00230,ko01100,map00230,map01100	-	R01244	RC00477	ko00000,ko00001,ko01000	-	-	-	Adenine_deam_C,Amidohydro_1
PYH3_k127_4183406_4	999630.TUZN_1858	2.067e-22	100.0	COG0430@1|root,arCOG04125@2157|Archaea,2XPT6@28889|Crenarchaeota	28889|Crenarchaeota	J	Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP	rtcA	GO:0003674,GO:0003824,GO:0003963,GO:0009975,GO:0016874,GO:0016886,GO:0140098	6.5.1.4	ko:K01974	-	-	-	-	ko00000,ko01000	-	-	-	RTC,RTC_insert
PYH3_k127_4183406_1	797209.ZOD2009_11065	1.35e-57	217.0	COG1084@1|root,arCOG00352@2157|Archaea,2XU5R@28890|Euryarchaeota,23TVR@183963|Halobacteria	183963|Halobacteria	S	GTP-binding protein	gbp4	-	-	ko:K06943	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	MMR_HSR1,NOG1
PYH3_k127_4183406_2	694429.Pyrfu_0204	3.882e-51	188.0	COG0638@1|root,arCOG00970@2157|Archaea,2XQG7@28889|Crenarchaeota	28889|Crenarchaeota	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	psmB1	-	3.4.25.1	ko:K03433	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
PYH3_k127_4183406_0	453591.Igni_1433	5.259e-77	268.0	COG0731@1|root,arCOG04174@2157|Archaea,2XPM3@28889|Crenarchaeota	28889|Crenarchaeota	C	Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe)	taw1	-	4.1.3.44	ko:K15449	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,Wyosine_form
PYH3_k127_4183406_3	523850.TON_0559	9.405e-24	108.0	COG2178@1|root,arCOG04318@2157|Archaea,2XYD0@28890|Euryarchaeota,242PY@183968|Thermococci	183968|Thermococci	J	Translin family	-	-	-	ko:K07477	-	-	-	-	ko00000	-	-	-	Translin
PYH3_k127_419089_2	391623.TERMP_01860	2.333e-41	169.0	COG1630@1|root,arCOG00367@2157|Archaea,2Y3KS@28890|Euryarchaeota,244XN@183968|Thermococci	183968|Thermococci	L	NurA	-	-	-	-	-	-	-	-	-	-	-	-	NurA
PYH3_k127_419089_0	368408.Tpen_1572	5.385e-156	509.0	COG0433@1|root,arCOG00280@2157|Archaea,2XQ2W@28889|Crenarchaeota	28889|Crenarchaeota	L	Type IV secretory system Conjugative DNA transfer	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF87
PYH3_k127_419089_1	1365176.N186_09575	7.166e-67	239.0	COG0420@1|root,arCOG00397@2157|Archaea,2XQWG@28889|Crenarchaeota	28889|Crenarchaeota	L	Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single- stranded endonuclease activity	mre11	-	-	ko:K03547	-	-	-	-	ko00000,ko03400	-	-	-	Metallophos,Metallophos_2
PYH3_k127_4269393_1	457570.Nther_2037	6.126e-171	549.0	COG0556@1|root,COG0556@2|Bacteria,1TPKB@1239|Firmicutes,247P7@186801|Clostridia	186801|Clostridia	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
PYH3_k127_4269393_0	642492.Clole_1645	0.0	1123.0	COG0178@1|root,COG0178@2|Bacteria,1TPIJ@1239|Firmicutes,2485F@186801|Clostridia	186801|Clostridia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
PYH3_k127_4269393_2	373903.Hore_16210	1.776e-146	484.0	COG0322@1|root,COG0322@2|Bacteria,1TP4B@1239|Firmicutes,247TQ@186801|Clostridia,3WAG5@53433|Halanaerobiales	186801|Clostridia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
PYH3_k127_4338285_0	1410620.SHLA_25c000880	3.692e-10	73.0	COG1409@1|root,COG1409@2|Bacteria,1MWC1@1224|Proteobacteria,2UR0J@28211|Alphaproteobacteria,4BFEF@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
PYH3_k127_4338285_1	1042877.GQS_10560	2.84e-06	54.0	COG1840@1|root,arCOG00221@2157|Archaea,2Y33A@28890|Euryarchaeota,243E5@183968|Thermococci	183968|Thermococci	P	Bacterial extracellular solute-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_8
PYH3_k127_4473058_2	386456.JQKN01000020_gene1335	1.24e-20	98.0	COG5440@1|root,arCOG01713@2157|Archaea,2XYFI@28890|Euryarchaeota,23PQ7@183925|Methanobacteria	183925|Methanobacteria	S	Uncharacterized conserved protein (DUF2299)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2299
PYH3_k127_4473058_3	1220534.B655_0937	1.557e-20	97.0	arCOG01917@1|root,arCOG01917@2157|Archaea	2157|Archaea	M	deoxyhypusine monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	zf-ribbon_3,zinc_ribbon_2
PYH3_k127_4473058_0	1220534.B655_0941	3.313e-187	595.0	COG1032@1|root,arCOG01356@2157|Archaea	2157|Archaea	C	SMART Elongator protein 3 MiaB NifB	-	-	1.21.98.3	ko:K04034	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R06268,R06269,R06270	RC00741,RC01491,RC01492	ko00000,ko00001,ko01000	-	-	-	B12-binding,Radical_SAM
PYH3_k127_4523831_0	1220534.B655_2381	8.147e-146	490.0	COG1202@1|root,arCOG03143@2157|Archaea,2Y86H@28890|Euryarchaeota,23PZG@183925|Methanobacteria	183925|Methanobacteria	S	helicase superfamily c-terminal domain	-	-	-	ko:K03725	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,Helicase_C
PYH3_k127_4523831_2	5850.PKH_110240	1.837e-14	82.0	COG1310@1|root,KOG1555@2759|Eukaryota,3Y9VG@5794|Apicomplexa,3KA8Q@422676|Aconoidasida,3YY33@5819|Haemosporida	422676|Aconoidasida	O	Proteasome regulatory subunit	-	-	-	ko:K03030	ko03050,ko05169,map03050,map05169	M00341	-	-	ko00000,ko00001,ko00002,ko01002,ko03051,ko04121	-	-	-	JAB,MitMem_reg
PYH3_k127_4523831_4	365044.Pnap_2813	1.229e-09	68.0	COG2018@1|root,COG2018@2|Bacteria,1RIQC@1224|Proteobacteria,2VTV9@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Roadblock/LC7 domain	-	-	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
PYH3_k127_4523831_3	673860.AciM339_0001	9.772e-11	74.0	COG1474@1|root,arCOG00467@2157|Archaea,2XU73@28890|Euryarchaeota,3F2IJ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Involved in regulation of DNA replication	cdc6	-	-	ko:K10725	-	-	-	-	ko00000,ko03032	-	-	-	AAA,AAA_16,AAA_22,Cdc6_C
PYH3_k127_4523831_1	1227457.C451_10860	1.122e-14	78.0	COG1628@1|root,arCOG00928@2157|Archaea,2XXBV@28890|Euryarchaeota,23VNR@183963|Halobacteria	183963|Halobacteria	L	Belongs to the UPF0215 family	-	-	-	ko:K09120	-	-	-	-	ko00000	-	-	-	DUF99
PYH3_k127_45440_1	795797.C497_00880	2.486e-07	63.0	COG0704@1|root,arCOG00318@2157|Archaea,2XUT8@28890|Euryarchaeota,23UD7@183963|Halobacteria	183963|Halobacteria	K	COG0704 Phosphate uptake regulator	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin,PhoU
PYH3_k127_45440_0	309799.DICTH_1530	1.111e-59	211.0	COG0778@1|root,COG0778@2|Bacteria	2|Bacteria	C	coenzyme F420-1:gamma-L-glutamate ligase activity	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Nitroreductase
PYH3_k127_45440_2	5722.XP_001316467.1	4.119e-07	54.0	KOG0094@1|root,KOG0094@2759|Eukaryota	5722.XP_001316467.1|-	S	retrograde vesicle-mediated transport, Golgi to ER	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_4548018_1	768710.DesyoDRAFT_1409	8.557e-41	157.0	COG1131@1|root,COG1131@2|Bacteria,1TQIH@1239|Firmicutes,248WG@186801|Clostridia,261DY@186807|Peptococcaceae	186801|Clostridia	V	ABC-type multidrug transport system ATPase	-	-	-	ko:K01990,ko:K16907	ko02010,map02010	M00224,M00254	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1	-	-	ABC_tran
PYH3_k127_4548018_0	646529.Desaci_3701	7.189e-234	754.0	COG0474@1|root,COG0474@2|Bacteria,1TPF5@1239|Firmicutes,247JN@186801|Clostridia,25ZY7@186807|Peptococcaceae	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
PYH3_k127_4548018_2	1220534.B655_0289	3.525e-09	66.0	COG1390@1|root,arCOG00869@2157|Archaea,2Y782@28890|Euryarchaeota,23P3B@183925|Methanobacteria	183925|Methanobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpE	-	-	ko:K02121	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_E
PYH3_k127_4555758_9	386456.JQKN01000002_gene2740	1.145e-30	131.0	COG0483@1|root,arCOG01349@2157|Archaea,2Y87S@28890|Euryarchaeota,23PI8@183925|Methanobacteria	183925|Methanobacteria	G	PFAM Inositol monophosphatase	-	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
PYH3_k127_4555758_11	273057.SSO6503	9.049e-19	89.0	COG1698@1|root,arCOG04308@2157|Archaea,2XQVN@28889|Crenarchaeota	28889|Crenarchaeota	S	Belongs to the UPF0147 family	-	-	-	ko:K09721	-	-	-	-	ko00000	-	-	-	UPF0147
PYH3_k127_4555758_12	397948.Cmaq_1659	7.785e-09	61.0	COG1645@1|root,arCOG00578@2157|Archaea,2XR3I@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM Sjogrens syndrome scleroderma autoantigen 1	-	-	-	ko:K07143	-	-	-	-	ko00000	-	-	-	Auto_anti-p27
PYH3_k127_4555758_0	342949.PNA2_0513	8.641e-202	655.0	COG1111@1|root,arCOG00872@2157|Archaea,2XTBV@28890|Euryarchaeota,243CX@183968|Thermococci	183968|Thermococci	L	ERCC4 domain	-	-	-	ko:K10896	ko03460,map03460	M00413	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	DEAD,ERCC4,HHH_2,Helicase_C
PYH3_k127_4555758_1	1041930.Mtc_2374	2.006e-140	469.0	COG0175@1|root,COG2768@1|root,arCOG00073@2157|Archaea,arCOG02448@2157|Archaea,2XUPU@28890|Euryarchaeota,2N9A2@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM PUA domain	-	-	1.8.4.10,1.8.4.8	ko:K00390	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R02021	RC00007,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A0559	Fer4,Fer4_10,PAPS_reduct,PUA
PYH3_k127_4555758_6	368407.Memar_0860	4.576e-50	202.0	COG3356@1|root,arCOG04351@2157|Archaea,2XVEY@28890|Euryarchaeota,2NAJK@224756|Methanomicrobia	224756|Methanomicrobia	S	Predicted membrane protein (DUF2070)	-	-	-	ko:K08979	-	-	-	-	ko00000	-	-	-	DUF2070
PYH3_k127_4555758_7	1183377.Py04_1082	2.096e-43	165.0	COG1014@1|root,arCOG01603@2157|Archaea,2XVFR@28890|Euryarchaeota,243DZ@183968|Thermococci	183968|Thermococci	C	pyruvate synthase activity	porG	-	1.2.7.1,1.2.7.7	ko:K00172,ko:K00189	ko00010,ko00020,ko00280,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00280,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R07160,R08034,R08566,R08567	RC00004,RC00250,RC02742,RC02833,RC02856	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
PYH3_k127_4555758_10	70601.3257087	1.512e-23	108.0	COG1144@1|root,arCOG01605@2157|Archaea,2XY2F@28890|Euryarchaeota,245HQ@183968|Thermococci	183968|Thermococci	C	3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) activity	vorD	-	1.2.7.7	ko:K00188	ko00280,ko01100,map00280,map01100	-	R07160,R08566,R08567	RC00004,RC02833,RC02856	br01601,ko00000,ko00001,ko01000	-	-	-	Fer4
PYH3_k127_4555758_3	374847.Kcr_1292	4.257e-114	381.0	COG0674@1|root,arCOG01608@2157|Archaea	2157|Archaea	C	PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein	vorA	-	1.2.7.1,1.2.7.7	ko:K00169,ko:K00186	ko00010,ko00020,ko00280,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00280,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R07160,R08034,R08566,R08567	RC00004,RC00250,RC02742,RC02833,RC02856	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
PYH3_k127_4555758_4	387631.Asulf_00879	7.801e-89	302.0	COG1013@1|root,arCOG01601@2157|Archaea,2XT3E@28890|Euryarchaeota,246RX@183980|Archaeoglobi	183980|Archaeoglobi	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	1.2.7.1	ko:K00170	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
PYH3_k127_4555758_5	1459636.NTE_01027	4.028e-73	263.0	COG1078@1|root,arCOG04430@2157|Archaea,41T0P@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K06885	-	-	-	-	ko00000	-	-	-	HD
PYH3_k127_4555758_8	368408.Tpen_0621	3.991e-31	135.0	COG1236@1|root,arCOG00545@2157|Archaea,2XQ4Z@28889|Crenarchaeota	28889|Crenarchaeota	J	exonuclease of the beta-lactamase fold involved in RNA processing	-	-	-	ko:K07577	-	-	-	-	ko00000	-	-	-	Lactamase_B,Lactamase_B_2,Lactamase_B_3
PYH3_k127_4555758_13	1131266.ARWQ01000006_gene249	0.0005146	47.0	COG4023@1|root,arCOG02957@2157|Archaea,41SUS@651137|Thaumarchaeota	651137|Thaumarchaeota	U	Sec61beta family	-	-	-	-	-	-	-	-	-	-	-	-	Sec61_beta
PYH3_k127_4555758_2	1459636.NTE_03553	1.955e-122	401.0	COG0112@1|root,arCOG00070@2157|Archaea,41S7U@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
PYH3_k127_4566358_0	1220534.B655_1297	1.337e-104	349.0	arCOG12322@1|root,arCOG12322@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_4566358_1	880072.Desac_0858	2.25e-44	171.0	COG2043@1|root,COG2043@2|Bacteria,1NR18@1224|Proteobacteria,42TWC@68525|delta/epsilon subdivisions,2WQ80@28221|Deltaproteobacteria,2MR2I@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Uncharacterised ArCR, COG2043	-	-	-	-	-	-	-	-	-	-	-	-	DUF169
PYH3_k127_4566358_3	387631.Asulf_00829	1.671e-06	55.0	COG1522@1|root,arCOG01585@2157|Archaea,2Y10I@28890|Euryarchaeota,246XF@183980|Archaeoglobi	183980|Archaeoglobi	K	helix_turn_helix ASNC type	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
PYH3_k127_4578993_3	593750.Metfor_2162	3.113e-16	83.0	COG0543@1|root,arCOG02199@2157|Archaea,2XSY9@28890|Euryarchaeota,2N98G@224756|Methanomicrobia	224756|Methanomicrobia	C	Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( )	pyrK	-	-	ko:K02823	ko00240,ko01100,map00240,map01100	-	-	-	ko00000,ko00001	-	-	-	DHODB_Fe-S_bind,NAD_binding_1
PYH3_k127_4578993_1	324057.Pjdr2_3313	2.255e-77	275.0	COG0044@1|root,COG0044@2|Bacteria,1TP8C@1239|Firmicutes,4HBNG@91061|Bacilli,26SI7@186822|Paenibacillaceae	91061|Bacilli	F	Catalyzes the conversion of allantoin (5- ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring	allB	-	3.5.2.5	ko:K01466	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R02425	RC00680	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
PYH3_k127_4578993_2	439481.Aboo_0832	2.524e-67	243.0	COG0167@1|root,arCOG00603@2157|Archaea,2XTMB@28890|Euryarchaeota,3F2FC@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	Catalyzes the conversion of dihydroorotate to orotate	pyrD	GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	1.3.1.14,1.3.5.2	ko:K00254,ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01868,R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
PYH3_k127_4578993_4	1540257.JQMW01000009_gene3474	1.584e-07	60.0	COG0454@1|root,COG0456@2|Bacteria,1VCRG@1239|Firmicutes,24HS4@186801|Clostridia,36JB9@31979|Clostridiaceae	186801|Clostridia	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
PYH3_k127_4578993_0	1365176.N186_07015	4.207e-84	285.0	COG0504@1|root,arCOG00063@2157|Archaea,2XPKS@28889|Crenarchaeota	28889|Crenarchaeota	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
PYH3_k127_458232_6	243232.MJ_0394	4.086e-11	69.0	COG2004@1|root,arCOG04182@2157|Archaea,2XXXB@28890|Euryarchaeota,23R5Q@183939|Methanococci	183939|Methanococci	J	Belongs to the eukaryotic ribosomal protein eS24 family	rps24e	-	-	ko:K02974	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S24e
PYH3_k127_458232_5	439481.Aboo_0564	1.171e-14	79.0	COG1998@1|root,arCOG04183@2157|Archaea,2XZZ0@28890|Euryarchaeota,3F2VM@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Belongs to the eukaryotic ribosomal protein eS31 family	rps27ae	-	-	ko:K02977	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko04147	-	-	-	Ribosomal_S27
PYH3_k127_458232_0	868131.MSWAN_2418	1.786e-105	352.0	COG0533@1|root,arCOG01183@2157|Archaea,arCOG01185@2157|Archaea,2XT07@28890|Euryarchaeota,23NPI@183925|Methanobacteria	183925|Methanobacteria	LT	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function	-	-	2.3.1.234,2.7.11.1	ko:K15904	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko01001,ko03016	-	-	-	Peptidase_M22,Pkinase,RIO1
PYH3_k127_458232_3	523850.TON_0709	3.807e-49	184.0	COG0533@1|root,arCOG01185@2157|Archaea,2XX5D@28890|Euryarchaeota,2436E@183968|Thermococci	183968|Thermococci	T	serine threonine protein kinase	-	GO:0000408,GO:0002949,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360	2.7.11.1	ko:K08851	-	-	-	-	ko00000,ko01000,ko01001,ko03016	-	-	-	RIO1
PYH3_k127_458232_4	1459636.NTE_02756	8.384e-46	173.0	COG0127@1|root,arCOG04184@2157|Archaea,41SKW@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Belongs to the HAM1 NTPase family	-	-	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
PYH3_k127_458232_2	644281.MFS40622_0943	6.66e-54	193.0	COG0184@1|root,arCOG04185@2157|Archaea,2XWKV@28890|Euryarchaeota,23QST@183939|Methanococci	183939|Methanococci	J	ribosomal protein S15	rps15	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13_N,Ribosomal_S15
PYH3_k127_458232_1	439481.Aboo_1116	1.368e-72	258.0	COG0608@1|root,arCOG00427@2157|Archaea,2XT8Y@28890|Euryarchaeota,3F2FV@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	DHHA1 domain	recJ	-	-	ko:K07463	-	-	-	-	ko00000	-	-	-	DHHA1
PYH3_k127_4582426_1	926550.CLDAP_17490	0.0007329	49.0	COG5337@1|root,COG5337@2|Bacteria	2|Bacteria	M	Spore coat protein CotH	-	-	-	-	-	-	-	-	-	-	-	-	CHB_HEX_C_1,CotH,Fn3_assoc,LTD
PYH3_k127_4582426_0	224325.AF_1027	1.16e-190	606.0	COG2368@1|root,arCOG02143@2157|Archaea,2Y372@28890|Euryarchaeota,246UM@183980|Archaeoglobi	183980|Archaeoglobi	Q	4-hydroxyphenylacetate 3-hydroxylase C terminal	-	-	1.14.14.9,4.2.1.120,5.3.3.3	ko:K00483,ko:K14534	ko00350,ko00650,ko00720,ko01100,ko01120,ko01200,ko01220,map00350,map00650,map00720,map01100,map01120,map01200,map01220	M00374,M00375	R02698,R03031,R03299,R10782	RC00046,RC01857,RC03277	ko00000,ko00001,ko00002,ko01000	-	-	-	HpaB,HpaB_N
PYH3_k127_4583792_1	374847.Kcr_0945	3.973e-07	60.0	arCOG09431@1|root,arCOG09431@2157|Archaea	2157|Archaea	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	DUF4430,PQQ_2,PQQ_3
PYH3_k127_4583792_0	529709.PYCH_13620	1.929e-68	252.0	COG0124@1|root,arCOG00404@2157|Archaea,2XSYX@28890|Euryarchaeota,242W2@183968|Thermococci	183968|Thermococci	J	Belongs to the class-II aminoacyl-tRNA synthetase family	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
PYH3_k127_4598956_0	404380.Gbem_0341	3.667e-29	127.0	COG2267@1|root,COG2267@2|Bacteria,1MX0N@1224|Proteobacteria,42P9B@68525|delta/epsilon subdivisions,2WMCP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4
PYH3_k127_4617828_8	459349.CLOAM1482	4.659e-31	126.0	COG2025@1|root,COG2025@2|Bacteria,2NNR6@2323|unclassified Bacteria	2|Bacteria	C	Electron transfer flavoprotein	fixB	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006091,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009055,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0019395,GO:0019752,GO:0022900,GO:0030258,GO:0032787,GO:0033539,GO:0034440,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071704,GO:0072329,GO:0097159,GO:1901265,GO:1901363,GO:1901575	1.3.1.108	ko:K03522,ko:K22432	-	-	-	-	ko00000,ko01000,ko04147	-	-	iAF987.Gmet_2066,iAF987.Gmet_2257	ETF,ETF_alpha,Fer4
PYH3_k127_4617828_2	401526.TcarDRAFT_1837	6.583e-93	312.0	COG2086@1|root,COG2086@2|Bacteria,1TQA0@1239|Firmicutes,4H2QE@909932|Negativicutes	909932|Negativicutes	C	Electron transfer flavoprotein	etfB	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
PYH3_k127_4617828_1	523850.TON_1075	1.02e-99	335.0	COG1703@1|root,arCOG01226@2157|Archaea,2XUHG@28890|Euryarchaeota,242YC@183968|Thermococci	183968|Thermococci	E	GTPase activity	-	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK
PYH3_k127_4617828_5	936589.HMPREF1521_0638	6.064e-59	206.0	COG2185@1|root,COG2185@2|Bacteria,1V3QN@1239|Firmicutes,4H4FB@909932|Negativicutes	909932|Negativicutes	I	B12- binding domain protein	-	-	5.4.99.2	ko:K01849	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding
PYH3_k127_4617828_0	1121430.JMLG01000036_gene164	1.263e-243	764.0	COG1884@1|root,COG1884@2|Bacteria,1TQAD@1239|Firmicutes,24BDK@186801|Clostridia,260X7@186807|Peptococcaceae	186801|Clostridia	I	TIGRFAM methylmalonyl-CoA mutase N-terminal domain	-	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
PYH3_k127_4617828_3	927677.ALVU02000001_gene3047	1.462e-85	301.0	COG0477@1|root,COG2814@2|Bacteria,1G2Z0@1117|Cyanobacteria	1117|Cyanobacteria	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
PYH3_k127_4617828_6	697281.Mahau_2062	5.037e-58	203.0	COG2033@1|root,COG2033@2|Bacteria,1VA34@1239|Firmicutes,24J9I@186801|Clostridia,42GIY@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM Desulfoferrodoxin ferrous iron-binding region	dfx	-	1.15.1.2	ko:K05919	-	-	-	-	ko00000,ko01000	-	-	-	Desulfoferrod_N,Desulfoferrodox
PYH3_k127_4617828_7	593750.Metfor_0800	3.524e-31	123.0	arCOG08014@1|root,arCOG08014@2157|Archaea,2Y5ZS@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_4617828_9	1304880.JAGB01000002_gene2292	4.817e-20	96.0	COG1773@1|root,COG1773@2|Bacteria,1VEQC@1239|Firmicutes,24QUV@186801|Clostridia	186801|Clostridia	C	rubredoxin	rd	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016491,GO:0017144,GO:0022900,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0055114,GO:0072592	1.18.1.1	ko:K05297	ko00071,map00071	-	R02000	-	ko00000,ko00001,ko01000	-	-	-	Rubredoxin
PYH3_k127_4617828_4	693661.Arcve_0650	1.958e-72	248.0	COG1592@1|root,arCOG01097@2157|Archaea,2XWSA@28890|Euryarchaeota	28890|Euryarchaeota	C	PFAM Rubrerythrin	rbr-1	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
PYH3_k127_4627688_3	1547437.LL06_23570	0.0002636	51.0	COG2020@1|root,COG2020@2|Bacteria,1MUBZ@1224|Proteobacteria,2TQZQ@28211|Alphaproteobacteria,43MJF@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	O	Isoprenylcysteine carboxyl methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	ICMT,PEMT
PYH3_k127_4627688_1	926569.ANT_17320	7.891e-21	100.0	29XJU@1|root,30JAW@2|Bacteria,2G9DS@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_4627688_2	1123376.AUIU01000015_gene439	3.109e-09	62.0	COG0640@1|root,COG0640@2|Bacteria,3J1BW@40117|Nitrospirae	40117|Nitrospirae	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
PYH3_k127_4627688_0	321327.CYA_1717	7.128e-84	291.0	COG0798@1|root,COG0798@2|Bacteria,1G05E@1117|Cyanobacteria,1H49F@1129|Synechococcus	1117|Cyanobacteria	P	Sodium Bile acid symporter family	-	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015104,GO:0015105,GO:0015291,GO:0015297,GO:0015318,GO:0015698,GO:0015699,GO:0015700,GO:0016020,GO:0022804,GO:0022857,GO:0034220,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656	-	ko:K03325	-	-	-	-	ko00000,ko02000	2.A.59	-	-	SBF
PYH3_k127_4655547_3	1128421.JAGA01000003_gene2815	1.5e-21	98.0	COG1082@1|root,COG1082@2|Bacteria,2NRRT@2323|unclassified Bacteria	2|Bacteria	G	Xylose isomerase domain protein TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
PYH3_k127_4655547_1	1157490.EL26_05445	1.498e-61	223.0	COG0613@1|root,COG0613@2|Bacteria,1TPI5@1239|Firmicutes,4HB6B@91061|Bacilli,278J9@186823|Alicyclobacillaceae	91061|Bacilli	S	DNA polymerase alpha chain like domain	php	-	3.1.3.97,3.1.4.57	ko:K07053,ko:K20859	ko00440,map00440	-	R00188,R10972,R10973,R11188	RC00078,RC00296	ko00000,ko00001,ko01000	-	-	-	PHP
PYH3_k127_4655547_0	698757.Pogu_0405	6.571e-82	289.0	COG1236@1|root,arCOG00541@2157|Archaea,2XPVA@28889|Crenarchaeota	28889|Crenarchaeota	J	PFAM beta-lactamase domain protein	-	-	-	ko:K07577	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,Lactamase_B_6,RMMBL
PYH3_k127_4655547_2	589924.Ferp_1044	1.028e-50	183.0	COG0318@1|root,arCOG00856@2157|Archaea,2XSZG@28890|Euryarchaeota,246WH@183980|Archaeoglobi	183980|Archaeoglobi	I	AMP-binding enzyme C-terminal domain	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
PYH3_k127_4682190_2	436308.Nmar_1793	6.376e-33	130.0	COG0112@1|root,arCOG00070@2157|Archaea,41S7U@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
PYH3_k127_4682190_1	386456.JQKN01000001_gene2146	7.916e-55	202.0	COG0517@1|root,arCOG00600@2157|Archaea,2XU4J@28890|Euryarchaeota,23NXA@183925|Methanobacteria	183925|Methanobacteria	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
PYH3_k127_4682190_0	224325.AF_1722	3.105e-206	666.0	COG1933@1|root,arCOG04447@2157|Archaea,2XU5S@28890|Euryarchaeota,246MU@183980|Archaeoglobi	183980|Archaeoglobi	L	Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase	polC	-	2.7.7.7	ko:K02322	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	M00264	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	PolC_DP2
PYH3_k127_471015_0	272557.APE_0812	5.741e-59	220.0	arCOG04155@1|root,arCOG04155@2157|Archaea,2XPKB@28889|Crenarchaeota	28889|Crenarchaeota	L	Iron-sulfur cluster loop	-	-	-	-	-	-	-	-	-	-	-	-	AGOG
PYH3_k127_471015_1	1123372.AUIT01000017_gene1573	5.184e-09	63.0	COG1661@1|root,COG1661@2|Bacteria,2GHT0@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	Domain of unknown function (DUF296)	-	-	-	ko:K06934	-	-	-	-	ko00000	-	-	-	DUF296
PYH3_k127_482904_2	33169.AAS51159	0.0006648	44.0	COG0554@1|root,KOG2517@2759|Eukaryota,38DGY@33154|Opisthokonta,3NUT5@4751|Fungi,3QN50@4890|Ascomycota,3RSDC@4891|Saccharomycetes,3RZCY@4893|Saccharomycetaceae	4751|Fungi	G	Belongs to the FGGY kinase family	GUT1	GO:0003674,GO:0003824,GO:0004370,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005975,GO:0006066,GO:0006071,GO:0006072,GO:0006629,GO:0006638,GO:0006639,GO:0006641,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019637,GO:0019751,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044255,GO:0044262,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046167,GO:0046486,GO:0052646,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901576,GO:1901615	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
PYH3_k127_482904_0	1184267.A11Q_2038	5.828e-33	146.0	COG2866@1|root,COG2866@2|Bacteria,1MZYN@1224|Proteobacteria,42PTT@68525|delta/epsilon subdivisions,2MT5U@213481|Bdellovibrionales,2WS13@28221|Deltaproteobacteria	213481|Bdellovibrionales	M	Zn_pept	-	-	3.4.17.18	ko:K05996	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M14
PYH3_k127_482904_1	45351.EDO46468	1.119e-13	76.0	COG5133@1|root,KOG3381@2759|Eukaryota,3A1NG@33154|Opisthokonta,3BQM5@33208|Metazoa	33208|Metazoa	S	iron-sulfur cluster assembly	FAM96B	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005819,GO:0005829,GO:0005856,GO:0006790,GO:0007059,GO:0008150,GO:0008152,GO:0009987,GO:0015630,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0031974,GO:0031981,GO:0032991,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044085,GO:0044237,GO:0044422,GO:0044424,GO:0044428,GO:0044430,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0051186,GO:0070013,GO:0071817,GO:0071840,GO:0097361	-	-	-	-	-	-	-	-	-	-	FeS_assembly_P
PYH3_k127_4831546_2	406327.Mevan_1070	1.568e-24	109.0	COG2016@1|root,arCOG00985@2157|Archaea,2XX1R@28890|Euryarchaeota,23QZV@183939|Methanococci	183939|Methanococci	J	PFAM PUA domain containing protein	-	GO:0001731,GO:0002181,GO:0002183,GO:0002188,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K07575	-	-	-	-	ko00000	-	-	-	DUF1947,PUA
PYH3_k127_4831546_4	694440.JOMF01000006_gene535	1.801e-09	63.0	COG2450@1|root,arCOG02263@2157|Archaea,2XXYF@28890|Euryarchaeota,2N9X3@224756|Methanomicrobia	224756|Methanomicrobia	D	Pfam:DUF552	-	-	-	ko:K09152	-	-	-	-	ko00000	-	-	-	SepF
PYH3_k127_4831546_0	1042877.GQS_01595	1.495e-65	237.0	COG2520@1|root,arCOG00033@2157|Archaea,2XTSI@28890|Euryarchaeota,242WN@183968|Thermococci	183968|Thermococci	J	Met-10+ like-protein	-	GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.228	ko:K15429	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	Met_10
PYH3_k127_4831546_1	368407.Memar_1982	3.293e-27	120.0	COG2090@1|root,arCOG04171@2157|Archaea,2XXWX@28890|Euryarchaeota,2NB77@224756|Methanomicrobia	224756|Methanomicrobia	S	Domain of unknown function (DUF371)	-	-	-	ko:K09738	-	-	-	-	ko00000	-	-	-	DUF371
PYH3_k127_4831546_3	243232.MJ_0172	8.836e-23	101.0	COG2518@1|root,arCOG00976@2157|Archaea,2XTRM@28890|Euryarchaeota,23QU4@183939|Methanococci	183939|Methanococci	J	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
PYH3_k127_4876434_12	1131266.ARWQ01000010_gene28	2.72e-05	47.0	COG1355@1|root,arCOG01728@2157|Archaea,41S9D@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Belongs to the MEMO1 family	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
PYH3_k127_4876434_6	439481.Aboo_0303	1.725e-32	134.0	COG1014@1|root,arCOG01602@2157|Archaea,2XXK2@28890|Euryarchaeota,3F2RE@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	TIGRFAM indolepyruvate ferredoxin oxidoreductase, beta subunit	iorB	-	1.2.7.8	ko:K00180	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR
PYH3_k127_4876434_0	1121405.dsmv_3816	2.623e-185	598.0	COG4231@1|root,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,42N44@68525|delta/epsilon subdivisions,2WIX6@28221|Deltaproteobacteria,2MHSF@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	iorA	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,POR_N,TPP_enzyme_C
PYH3_k127_4876434_7	694440.JOMF01000005_gene329	3.177e-26	123.0	COG1746@1|root,arCOG04249@2157|Archaea,2XT5J@28890|Euryarchaeota,2N94Y@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate	cca	-	2.7.7.72	ko:K07558	-	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko01000,ko03016	-	-	-	NTP_transf_2,tRNA_NucTransf2
PYH3_k127_4876434_8	720555.BATR1942_15965	7.379e-18	89.0	COG1522@1|root,COG1522@2|Bacteria,1V1DR@1239|Firmicutes,4HFRT@91061|Bacilli,1ZG22@1386|Bacillus	91061|Bacilli	K	Transcriptional regulator	ywrC	GO:0001101,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010033,GO:0010243,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0042221,GO:0043200,GO:0043565,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1901698,GO:1901700,GO:1903506,GO:2000112,GO:2001141	-	ko:K03719	-	-	-	-	ko00000,ko03000,ko03036	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
PYH3_k127_4876434_4	648996.Theam_0108	1.67e-49	183.0	COG2078@1|root,COG2078@2|Bacteria,2G44K@200783|Aquificae	200783|Aquificae	S	PFAM AMMECR1 domain protein	-	-	-	ko:K09141	-	-	-	-	ko00000	-	-	-	AMMECR1
PYH3_k127_4876434_5	1220534.B655_1736	5.336e-42	165.0	COG0517@1|root,arCOG00601@2157|Archaea,2XT75@28890|Euryarchaeota,23PXC@183925|Methanobacteria	183925|Methanobacteria	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
PYH3_k127_4876434_1	529709.PYCH_07400	1.883e-110	381.0	COG1293@1|root,arCOG01695@2157|Archaea,2XTMF@28890|Euryarchaeota,243BD@183968|Thermococci	183968|Thermococci	K	Fibronectin-binding protein A N-terminus (FbpA)	-	-	-	-	-	-	-	-	-	-	-	-	DUF814,FbpA
PYH3_k127_4876434_10	391623.TERMP_00983	1.065e-09	66.0	COG1522@1|root,arCOG01580@2157|Archaea,2XXGY@28890|Euryarchaeota,243ZR@183968|Thermococci	183968|Thermococci	K	transcription regulator activity	-	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K03718	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
PYH3_k127_4876434_2	342949.PNA2_0706	1.378e-73	255.0	COG0467@1|root,arCOG01171@2157|Archaea,2Y7MQ@28890|Euryarchaeota,243HH@183968|Thermococci	183968|Thermococci	T	KaiC	-	-	-	-	-	-	-	-	-	-	-	-	ATPase
PYH3_k127_4876434_9	1163730.FFONT_0380	7.121e-16	82.0	COG0640@1|root,arCOG01679@2157|Archaea,2XR0G@28889|Crenarchaeota	28889|Crenarchaeota	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
PYH3_k127_4876434_3	415426.Hbut_0072	3.574e-58	213.0	COG0478@1|root,arCOG01181@2157|Archaea,2XPM0@28889|Crenarchaeota	28889|Crenarchaeota	T	RIO-like serine threonine protein kinase fused to N-terminal HTH domain	-	-	2.7.11.1	ko:K07179	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko01001,ko03009	-	-	-	RIO1,Rio2_N
PYH3_k127_4876434_11	269797.Mbar_A3698	7.925e-06	53.0	COG2433@1|root,arCOG04219@2157|Archaea,2XT3D@28890|Euryarchaeota,2N92G@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF460)	-	-	-	ko:K09150	-	-	-	-	ko00000	-	-	-	DUF460
PYH3_k127_4890595_0	269797.Mbar_A3188	3.196e-150	490.0	COG0213@1|root,arCOG02013@2157|Archaea,2XT19@28890|Euryarchaeota,2N9C6@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO	deoA	-	2.4.2.57	ko:K18931	-	-	R10836,R10837,R10838	RC00063	ko00000,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3,Molydop_binding,PYNP_C
PYH3_k127_4890595_2	178306.PAE0771	1.387e-40	158.0	COG0456@1|root,arCOG00833@2157|Archaea,2XQJH@28889|Crenarchaeota	28889|Crenarchaeota	S	TIGRFAM ribosomal-protein-alanine acetyltransferase	-	GO:0003674,GO:0003824,GO:0004596,GO:0005575,GO:0005622,GO:0005623,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0031248,GO:0031365,GO:0032991,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051604,GO:0071704,GO:1901564,GO:1902493,GO:1902494,GO:1990234	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
PYH3_k127_4890595_1	868131.MSWAN_1901	7.189e-45	177.0	COG0750@1|root,arCOG00609@2157|Archaea,2XT29@28890|Euryarchaeota	28890|Euryarchaeota	M	membrane-associated Zn-dependent proteases 1	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
PYH3_k127_4934467_5	985053.VMUT_0373	2.396e-16	85.0	COG1650@1|root,arCOG01616@2157|Archaea,2XPQP@28889|Crenarchaeota	28889|Crenarchaeota	J	D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo	dtdA	-	3.1.1.96	ko:K09716	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_deacylase
PYH3_k127_4934467_0	264732.Moth_2286	5.055e-110	364.0	COG0078@1|root,COG0078@2|Bacteria,1TPF2@1239|Firmicutes,248I5@186801|Clostridia,42EK4@68295|Thermoanaerobacterales	186801|Clostridia	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	-	2.1.3.3,2.1.3.9	ko:K00611,ko:K09065	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01398,R07245	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
PYH3_k127_4934467_1	523850.TON_0592	2.482e-95	321.0	COG0552@1|root,arCOG01227@2157|Archaea,2XUBI@28890|Euryarchaeota,242QW@183968|Thermococci	183968|Thermococci	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
PYH3_k127_4934467_9	304371.MCP_0009	0.0002252	49.0	COG1730@1|root,arCOG01341@2157|Archaea,2Y0EU@28890|Euryarchaeota,2NBIM@224756|Methanomicrobia	224756|Methanomicrobia	O	Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding	pfdA	-	-	ko:K04797	-	-	-	-	ko00000,ko03110	-	-	-	Prefoldin
PYH3_k127_4934467_7	604354.TSIB_0647	4.079e-11	67.0	COG2157@1|root,arCOG04175@2157|Archaea,2Y0R1@28890|Euryarchaeota,244JC@183968|Thermococci	183968|Thermococci	J	rRNA binding	rplX	-	-	ko:K02944	ko03010,map03010	M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18A
PYH3_k127_4934467_2	1151117.AJLF01000001_gene834	1.417e-42	164.0	COG1976@1|root,arCOG04176@2157|Archaea,2XU7N@28890|Euryarchaeota,243II@183968|Thermococci	183968|Thermococci	J	Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex	eif6	GO:0000460,GO:0000470,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0030684,GO:0030687,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042273,GO:0043021,GO:0043023,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046483,GO:0065003,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360,GO:1902626,GO:1990904	-	ko:K03264	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009,ko03012	-	-	-	eIF-6
PYH3_k127_4934467_4	572478.Vdis_2538	1.799e-17	86.0	COG2097@1|root,arCOG04473@2157|Archaea,2XR1E@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the ribosomal protein L31e family	rpl31e	GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02910	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31e
PYH3_k127_4934467_8	273063.STK_13727	7.808e-09	61.0	COG2167@1|root,arCOG04177@2157|Archaea,2XRC0@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eL39 family	rpl39e	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02924	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L39
PYH3_k127_4934467_6	419665.Maeo_0998	4.825e-14	76.0	COG2118@1|root,arCOG04179@2157|Archaea,2XZUR@28890|Euryarchaeota,23R6F@183939|Methanococci	183939|Methanococci	S	Belongs to the PDCD5 family	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K06875	-	-	-	-	ko00000	-	-	-	dsDNA_bind
PYH3_k127_4934467_3	573064.Mefer_0609	4.844e-34	133.0	COG2238@1|root,arCOG01344@2157|Archaea,2XXA6@28890|Euryarchaeota,23QVX@183939|Methanococci	183939|Methanococci	J	May be involved in maturation of the 30S ribosomal subunit	rps19e	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02966	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19e
PYH3_k127_4953841_0	525904.Tter_2104	1.543e-38	155.0	COG0500@1|root,COG2226@2|Bacteria,2NQ3S@2323|unclassified Bacteria	2|Bacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25,Methyltransf_31
PYH3_k127_4974278_3	646529.Desaci_3105	0.0003691	51.0	COG0457@1|root,COG0457@2|Bacteria,1V2K9@1239|Firmicutes,24GIW@186801|Clostridia,261GT@186807|Peptococcaceae	186801|Clostridia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_12,TPR_8
PYH3_k127_4974278_1	572546.Arcpr_1724	1.568e-95	332.0	COG1032@1|root,arCOG01357@2157|Archaea,2XUCZ@28890|Euryarchaeota,246Y8@183980|Archaeoglobi	183980|Archaeoglobi	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
PYH3_k127_4974278_0	1121289.JHVL01000013_gene1638	1.211e-96	320.0	COG2368@1|root,COG2368@2|Bacteria,1TQ70@1239|Firmicutes,248RP@186801|Clostridia,36DTV@31979|Clostridiaceae	186801|Clostridia	Q	4-hydroxyphenylacetate 3-hydroxylase C terminal	abfD	-	1.14.14.9,4.2.1.120,5.3.3.3	ko:K00483,ko:K14534	ko00350,ko00650,ko00720,ko01100,ko01120,ko01200,ko01220,map00350,map00650,map00720,map01100,map01120,map01200,map01220	M00374,M00375	R02698,R03031,R03299,R10782	RC00046,RC01857,RC03277	ko00000,ko00001,ko00002,ko01000	-	-	-	HpaB,HpaB_N
PYH3_k127_4974454_2	70601.3257217	4.766e-16	84.0	COG0747@1|root,arCOG01534@2157|Archaea,2XVBN@28890|Euryarchaeota,245ET@183968|Thermococci	183968|Thermococci	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
PYH3_k127_4974454_1	9778.XP_004368437.1	3.928e-36	145.0	KOG0084@1|root,KOG0084@2759|Eukaryota,38GAJ@33154|Opisthokonta,3BHNS@33208|Metazoa,3D3MC@33213|Bilateria,486WI@7711|Chordata,48ZSF@7742|Vertebrata,3JAN8@40674|Mammalia,3560M@311790|Afrotheria	33208|Metazoa	TU	Ras-related protein Rab-43	RAB43	GO:0000139,GO:0001894,GO:0002065,GO:0002067,GO:0002376,GO:0003674,GO:0003824,GO:0003924,GO:0005096,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005768,GO:0005794,GO:0005802,GO:0006810,GO:0006950,GO:0006952,GO:0006955,GO:0006996,GO:0007030,GO:0007154,GO:0007165,GO:0007264,GO:0007265,GO:0008047,GO:0008150,GO:0009888,GO:0009987,GO:0010033,GO:0010256,GO:0012505,GO:0016020,GO:0016032,GO:0016043,GO:0016192,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0019058,GO:0019068,GO:0023052,GO:0030139,GO:0030154,GO:0030234,GO:0030695,GO:0030855,GO:0031090,GO:0031410,GO:0031982,GO:0031984,GO:0032482,GO:0032501,GO:0032502,GO:0032588,GO:0034097,GO:0034341,GO:0035526,GO:0035556,GO:0035883,GO:0036477,GO:0042221,GO:0042592,GO:0043025,GO:0043085,GO:0043087,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043547,GO:0044093,GO:0044297,GO:0044403,GO:0044419,GO:0044422,GO:0044424,GO:0044431,GO:0044444,GO:0044446,GO:0044464,GO:0045087,GO:0045202,GO:0045335,GO:0045595,GO:0048856,GO:0048869,GO:0048871,GO:0048872,GO:0048873,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050896,GO:0051179,GO:0051234,GO:0051336,GO:0051345,GO:0051704,GO:0051716,GO:0060249,GO:0060429,GO:0060589,GO:0060786,GO:0065007,GO:0065008,GO:0065009,GO:0070887,GO:0071310,GO:0071345,GO:0071346,GO:0071840,GO:0090382,GO:0097458,GO:0097708,GO:0098588,GO:0098772,GO:0098791,GO:1901998	-	ko:K07930	-	-	-	-	ko00000,ko04031,ko04147	-	-	-	Ras
PYH3_k127_4974454_3	1323663.AROI01000021_gene964	7.815e-06	54.0	COG1030@1|root,COG1030@2|Bacteria,1MUJN@1224|Proteobacteria,1RN3U@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Membrane-bound serine protease (ClpP class)	nfeD	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	NfeD
PYH3_k127_4974454_0	1365176.N186_02585	1.239e-53	207.0	COG0624@1|root,arCOG01107@2157|Archaea,2XPWH@28889|Crenarchaeota	28889|Crenarchaeota	E	TIGRFAM acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase	argE	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
PYH3_k127_4979219_7	573413.Spirs_2838	0.0006075	50.0	28N23@1|root,2ZB80@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	ECF-ribofla_trS
PYH3_k127_4979219_4	529709.PYCH_09190	4.865e-34	140.0	COG0491@1|root,arCOG00504@2157|Archaea,2XURS@28890|Euryarchaeota,2430W@183968|Thermococci	183968|Thermococci	S	Metallo-beta-lactamase superfamily	-	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
PYH3_k127_4979219_3	1120973.AQXL01000118_gene491	1.771e-36	143.0	COG2041@1|root,COG2041@2|Bacteria,1V1P9@1239|Firmicutes,4HFQC@91061|Bacilli,278B0@186823|Alicyclobacillaceae	91061|Bacilli	S	Oxidoreductase molybdopterin binding domain	yuiH	-	-	-	-	-	-	-	-	-	-	-	Oxidored_molyb
PYH3_k127_4979219_6	1227497.C491_08794	8.23e-12	67.0	COG2041@1|root,arCOG00264@2157|Archaea,2XU2G@28890|Euryarchaeota,23SCW@183963|Halobacteria	183963|Halobacteria	S	COG2041 Sulfite oxidase and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_molyb
PYH3_k127_4979219_5	673860.AciM339_0628	2.363e-16	83.0	arCOG05238@1|root,arCOG05238@2157|Archaea,2Y0YG@28890|Euryarchaeota,3F3EA@33867|unclassified Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_4979219_1	373903.Hore_06890	4.701e-110	368.0	COG2309@1|root,COG2309@2|Bacteria,1TP65@1239|Firmicutes,24AR8@186801|Clostridia,3WANK@53433|Halanaerobiales	186801|Clostridia	E	Thermophilic metalloprotease (M29)	pepS	-	-	ko:K19689	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M29
PYH3_k127_4979219_0	373903.Hore_21960	1.832e-135	466.0	COG0474@1|root,COG0474@2|Bacteria,1TPF5@1239|Firmicutes,247JN@186801|Clostridia,3WB3A@53433|Halanaerobiales	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
PYH3_k127_4979219_2	368407.Memar_2430	1.358e-106	350.0	COG0466@1|root,arCOG02160@2157|Archaea,2XTT0@28890|Euryarchaeota,2N9CG@224756|Methanomicrobia	2157|Archaea	O	Belongs to the peptidase S16 family	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_5040021_6	365044.Pnap_4519	2.97e-08	62.0	COG2020@1|root,COG2020@2|Bacteria,1MUBZ@1224|Proteobacteria,2VJJ4@28216|Betaproteobacteria,4ACHF@80864|Comamonadaceae	28216|Betaproteobacteria	O	PFAM Isoprenylcysteine carboxyl methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	ICMT,PEMT
PYH3_k127_5040021_0	485913.Krac_9606	1.769e-80	278.0	COG2267@1|root,COG2267@2|Bacteria,2G8RT@200795|Chloroflexi	200795|Chloroflexi	I	Alpha/beta hydrolase family	-	-	-	ko:K22318	-	-	-	-	ko00000	-	-	-	Abhydrolase_1
PYH3_k127_5040021_1	439235.Dalk_1235	4.794e-62	224.0	COG0491@1|root,COG0491@2|Bacteria,1RIF3@1224|Proteobacteria,42TFP@68525|delta/epsilon subdivisions,2WP7U@28221|Deltaproteobacteria,2MK3E@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
PYH3_k127_5040021_5	593750.Metfor_1841	2.327e-10	69.0	arCOG03597@1|root,arCOG03597@2157|Archaea	2157|Archaea	S	Protein of unknown function (DUF2769)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2769
PYH3_k127_5040021_2	1033810.HLPCO_000861	3.031e-39	156.0	COG0500@1|root,COG2226@2|Bacteria,2NQ2E@2323|unclassified Bacteria	2|Bacteria	Q	Methionine biosynthesis protein MetW	-	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31
PYH3_k127_5040021_4	326427.Cagg_1682	5.354e-23	102.0	COG0640@1|root,COG0640@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	MA20_23570	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_34
PYH3_k127_5040021_3	768710.DesyoDRAFT_1409	6.712e-33	134.0	COG1131@1|root,COG1131@2|Bacteria,1TQIH@1239|Firmicutes,248WG@186801|Clostridia,261DY@186807|Peptococcaceae	186801|Clostridia	V	ABC-type multidrug transport system ATPase	-	-	-	ko:K01990,ko:K16907	ko02010,map02010	M00224,M00254	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1	-	-	ABC_tran
PYH3_k127_5086028_0	379066.GAU_0097	1.183e-56	218.0	COG2234@1|root,COG2234@2|Bacteria	2|Bacteria	DZ	aminopeptidase activity	-	-	-	ko:K07004	-	-	-	-	ko00000	-	-	-	PKD,PPC,Peptidase_M10,Peptidase_M28,SLH
PYH3_k127_5086028_1	266117.Rxyl_0369	5.881e-36	148.0	COG2141@1|root,COG2141@2|Bacteria,2H0K9@201174|Actinobacteria,4CTCQ@84995|Rubrobacteria	84995|Rubrobacteria	C	PFAM luciferase-like	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
PYH3_k127_5129055_7	1343739.PAP_08315	2.857e-12	72.0	COG1310@1|root,arCOG01138@2157|Archaea,2Y1J4@28890|Euryarchaeota,244HG@183968|Thermococci	183968|Thermococci	S	JAB/MPN domain	-	-	-	-	-	-	-	-	-	-	-	-	Prok-JAB
PYH3_k127_5129055_9	222984.JNCS01000002_gene1271	1.291e-09	64.0	COG1369@1|root,arCOG01365@2157|Archaea,2XX63@28890|Euryarchaeota,23VN6@183963|Halobacteria	183963|Halobacteria	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp2	-	3.1.26.5	ko:K03537	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03016,ko03029	-	-	-	RNase_P_Rpp14
PYH3_k127_5129055_8	1094980.Mpsy_2724	5.077e-10	68.0	COG1603@1|root,arCOG00307@2157|Archaea,2XU7Q@28890|Euryarchaeota,2N9T6@224756|Methanomicrobia	224756|Methanomicrobia	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp3	-	3.1.26.5	ko:K03539	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03016,ko03029	-	-	-	RNase_P_p30
PYH3_k127_5129055_6	694429.Pyrfu_0825	7.036e-17	86.0	COG1325@1|root,arCOG01042@2157|Archaea,2XQSI@28889|Crenarchaeota	28889|Crenarchaeota	J	exosome subunit	-	-	-	ko:K07581	-	-	-	-	ko00000	-	-	-	RNA_binding
PYH3_k127_5129055_3	1343739.PAP_02030	1.008e-64	227.0	COG1632@1|root,arCOG04209@2157|Archaea,2XTJJ@28890|Euryarchaeota,242MQ@183968|Thermococci	183968|Thermococci	J	Belongs to the eukaryotic ribosomal protein eL15 family	rpl15e	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02877	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L15e
PYH3_k127_5129055_2	644966.Tmar_0517	1.231e-87	299.0	COG1052@1|root,COG1052@2|Bacteria,1TPCX@1239|Firmicutes,25F0C@186801|Clostridia,3WD52@538999|Clostridiales incertae sedis	186801|Clostridia	CH	PFAM D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain	-	-	1.1.1.26,1.1.1.310,1.1.1.399,1.1.1.95	ko:K00015,ko:K00058,ko:K16843	ko00260,ko00270,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00020	R00717,R01388,R01513,R05693	RC00031,RC00042	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
PYH3_k127_5129055_0	1459636.NTE_02760	2.398e-121	402.0	COG0012@1|root,arCOG00357@2157|Archaea,41S71@651137|Thaumarchaeota	651137|Thaumarchaeota	J	GTPase of unknown function C-terminal	-	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,MMR_HSR1_C,TGS
PYH3_k127_5129055_5	342949.PNA2_0184	4.383e-25	110.0	COG4003@1|root,arCOG05763@2157|Archaea,2Y3NV@28890|Euryarchaeota,2446V@183968|Thermococci	183968|Thermococci	S	Uncharacterized protein conserved in archaea (DUF2095)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2095
PYH3_k127_5129055_1	868131.MSWAN_1530	7.064e-100	345.0	COG1032@1|root,arCOG01355@2157|Archaea,2XUPV@28890|Euryarchaeota,23NTW@183925|Methanobacteria	183925|Methanobacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
PYH3_k127_5129055_4	415426.Hbut_0428	1.021e-58	210.0	COG1890@1|root,arCOG04186@2157|Archaea,2XPNX@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eS1 family	rps3ae	GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576	-	ko:K02984	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S3Ae
PYH3_k127_5130286_2	1304284.L21TH_1757	4.156e-10	74.0	COG1404@1|root,COG1404@2|Bacteria,1TQRU@1239|Firmicutes,249H1@186801|Clostridia,36FNC@31979|Clostridiaceae	186801|Clostridia	O	peptidase S8 and S53, subtilisin, kexin, sedolisin	aprX	-	-	ko:K17734	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S8
PYH3_k127_5130286_0	693661.Arcve_1732	1.534e-38	156.0	COG1131@1|root,arCOG00194@2157|Archaea,2XUK9@28890|Euryarchaeota	28890|Euryarchaeota	E	COG1131 ABC-type multidrug transport system ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
PYH3_k127_5130286_1	3885.XP_007160529.1	3.007e-38	149.0	COG1100@1|root,KOG0087@2759|Eukaryota,37J63@33090|Viridiplantae,3GG35@35493|Streptophyta,4JE6B@91835|fabids	35493|Streptophyta	U	Ras-related protein RABA6a-like	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005768,GO:0005886,GO:0012505,GO:0016020,GO:0031410,GO:0031982,GO:0043226,GO:0043227,GO:0043229,GO:0044424,GO:0044444,GO:0044464,GO:0071944,GO:0097708	-	ko:K07976	-	-	-	-	ko00000,ko04031	-	-	-	Ras
PYH3_k127_5151650_0	1408324.JNJK01000016_gene151	8.002e-53	192.0	COG1853@1|root,COG1853@2|Bacteria,1V1EA@1239|Firmicutes,24FWS@186801|Clostridia,27MEN@186928|unclassified Lachnospiraceae	186801|Clostridia	S	Flavin reductase like domain	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
PYH3_k127_5151650_1	1449343.JQLQ01000002_gene2426	2.714e-34	139.0	COG1584@1|root,COG1584@2|Bacteria,1TSYX@1239|Firmicutes,4HEDP@91061|Bacilli,27GNS@186828|Carnobacteriaceae	91061|Bacilli	S	GPR1/FUN34/yaaH family	-	-	-	ko:K07034	-	-	-	-	ko00000	-	-	-	Grp1_Fun34_YaaH
PYH3_k127_5177720_1	391625.PPSIR1_36707	7.992e-39	147.0	COG1225@1|root,COG1225@2|Bacteria	2|Bacteria	O	peroxiredoxin activity	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
PYH3_k127_5177720_2	1197130.BAFM01000011_gene2073	9.77e-08	63.0	COG1714@1|root,arCOG03633@2157|Archaea,2XYB1@28890|Euryarchaeota,23WIB@183963|Halobacteria	183963|Halobacteria	S	RDD family	-	-	-	-	-	-	-	-	-	-	-	-	RDD
PYH3_k127_5177720_0	1232410.KI421413_gene766	3.218e-70	244.0	COG1145@1|root,COG1145@2|Bacteria,1PW12@1224|Proteobacteria,42MZ9@68525|delta/epsilon subdivisions,2WN0W@28221|Deltaproteobacteria,43SWA@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_6
PYH3_k127_5214054_2	694429.Pyrfu_0160	4.866e-27	117.0	COG3620@1|root,arCOG00608@2157|Archaea,2XR1X@28889|Crenarchaeota	28889|Crenarchaeota	K	PFAM CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,HTH_3
PYH3_k127_5214054_0	246969.TAM4_1253	1.264e-153	505.0	COG0068@1|root,arCOG01187@2157|Archaea,2XTHZ@28890|Euryarchaeota,242XT@183968|Thermococci	183968|Thermococci	O	Belongs to the carbamoyltransferase HypF family	hypF	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Peptidase_M22,Sua5_yciO_yrdC,zf-HYPF
PYH3_k127_5214054_1	519442.Huta_2342	8.52e-30	124.0	COG0068@1|root,arCOG01187@2157|Archaea,2XTHZ@28890|Euryarchaeota,23TXB@183963|Halobacteria	183963|Halobacteria	O	Belongs to the carbamoyltransferase HypF family	-	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
PYH3_k127_5214054_3	1449353.JQMQ01000005_gene248	6.319e-05	49.0	COG1940@1|root,COG1940@2|Bacteria,2GJ2S@201174|Actinobacteria,2NEVJ@228398|Streptacidiphilus	201174|Actinobacteria	GK	ROK family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24,ROK
PYH3_k127_5237955_0	368407.Memar_2034	9.908e-140	460.0	COG0477@1|root,arCOG00141@2157|Archaea,2Y3ND@28890|Euryarchaeota	28890|Euryarchaeota	G	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_5237955_1	323259.Mhun_0872	1.534e-66	236.0	COG0798@1|root,arCOG02190@2157|Archaea,2XTQC@28890|Euryarchaeota	28890|Euryarchaeota	P	COG0798 Arsenite efflux pump ACR3 and related permeases	-	-	-	ko:K03325	-	-	-	-	ko00000,ko02000	2.A.59	-	-	SBF
PYH3_k127_5283985_0	368408.Tpen_1196	2.518e-112	379.0	COG0531@1|root,arCOG00009@2157|Archaea,2XRZZ@28889|Crenarchaeota	28889|Crenarchaeota	E	PFAM amino acid permease-associated region	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
PYH3_k127_5283985_1	693661.Arcve_0237	1.296e-50	183.0	COG0863@1|root,arCOG00115@2157|Archaea,2XT30@28890|Euryarchaeota,246GU@183980|Archaeoglobi	183980|Archaeoglobi	L	DNA methylase	-	-	2.1.1.113	ko:K00590	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
PYH3_k127_5304260_1	575540.Isop_1013	4.673e-41	160.0	COG1795@1|root,COG1795@2|Bacteria,2IYXA@203682|Planctomycetes	203682|Planctomycetes	S	PFAM Formaldehyde-activating enzyme (Fae)	-	-	4.2.1.147	ko:K10713	ko00680,ko01120,ko01200,map00680,map01120,map01200	-	R08058	RC01583,RC01795	ko00000,ko00001,ko01000	-	-	-	Fae
PYH3_k127_5304260_2	634498.mru_1559	5.727e-31	134.0	COG1767@1|root,arCOG04238@2157|Archaea,2XT6S@28890|Euryarchaeota,23P0Y@183925|Methanobacteria	183925|Methanobacteria	H	ATP dephospho-CoA triphosphoribosyl transferase	citG	-	2.4.2.52	ko:K05966	ko02020,map02020	-	R09675	RC00049,RC00063	ko00000,ko00001,ko01000	-	-	-	CitG
PYH3_k127_5304260_0	1196323.ALKF01000182_gene5212	4.755e-59	222.0	COG0624@1|root,COG0624@2|Bacteria,1UY58@1239|Firmicutes,4HD63@91061|Bacilli,2750E@186822|Paenibacillaceae	91061|Bacilli	E	succinyl-diaminopimelate desuccinylase	-	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
PYH3_k127_5304260_3	1273125.Rrhod_1703	3.179e-06	53.0	COG1545@1|root,COG1545@2|Bacteria,2HQJX@201174|Actinobacteria,4G8ET@85025|Nocardiaceae	201174|Actinobacteria	S	DUF35 OB-fold domain, acyl-CoA-associated	-	-	-	-	-	-	-	-	-	-	-	-	OB_aCoA_assoc
PYH3_k127_5362229_0	1191523.MROS_1378	1.965e-88	295.0	COG0499@1|root,COG0499@2|Bacteria	2|Bacteria	H	adenosylhomocysteinase activity	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
PYH3_k127_5362229_3	1089553.Tph_c18080	1.183e-36	150.0	COG0266@1|root,COG0266@2|Bacteria,1TPM9@1239|Firmicutes,24BH2@186801|Clostridia,42G5U@68295|Thermoanaerobacterales	186801|Clostridia	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	fpg	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
PYH3_k127_5362229_1	706587.Desti_2453	1.53e-76	265.0	COG1250@1|root,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,42M6J@68525|delta/epsilon subdivisions,2WJZQ@28221|Deltaproteobacteria,2MQSA@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	PFAM 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
PYH3_k127_5362229_2	1449126.JQKL01000031_gene1144	3.094e-59	216.0	COG1024@1|root,COG1024@2|Bacteria,1TQ89@1239|Firmicutes,247RK@186801|Clostridia,267WS@186813|unclassified Clostridiales	186801|Clostridia	I	Enoyl-CoA hydratase/isomerase	crt	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	-	ECH_1
PYH3_k127_548591_4	604354.TSIB_1448	1.169e-12	79.0	arCOG02559@1|root,arCOG02559@2157|Archaea,2XYKK@28890|Euryarchaeota,24394@183968|Thermococci	183968|Thermococci	KLT	Serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	DUF5122
PYH3_k127_548591_2	56780.SYN_01286	1.579e-28	123.0	COG1913@1|root,COG1913@2|Bacteria,1N38I@1224|Proteobacteria,42UMZ@68525|delta/epsilon subdivisions,2WRS9@28221|Deltaproteobacteria,2MS0H@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Peptidase family M54	-	-	-	ko:K06974	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M54
PYH3_k127_548591_3	368407.Memar_1868	3.997e-21	108.0	arCOG02559@1|root,arCOG02559@2157|Archaea,2XYKK@28890|Euryarchaeota,2NBHR@224756|Methanomicrobia	224756|Methanomicrobia	O	by modhmm	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_548591_1	118161.KB235923_gene6583	1.846e-38	148.0	COG0537@1|root,COG0537@2|Bacteria	2|Bacteria	FG	bis(5'-adenosyl)-triphosphatase activity	hit-1	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
PYH3_k127_548591_0	399550.Smar_1199	8.953e-228	723.0	COG2414@1|root,arCOG00707@2157|Archaea,2XPRY@28889|Crenarchaeota	28889|Crenarchaeota	C	PFAM Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
PYH3_k127_548591_5	1104324.P186_0799	0.0006154	51.0	COG0330@1|root,COG4260@1|root,arCOG01918@2157|Archaea,arCOG05711@2157|Archaea,2XQFU@28889|Crenarchaeota	28889|Crenarchaeota	O	virion core protein (lumpy skin disease virus)	-	-	-	-	-	-	-	-	-	-	-	-	Band_7,Band_7_1,SHOCT
PYH3_k127_5513506_1	579137.Metvu_0714	2.562e-97	334.0	COG1148@1|root,arCOG02235@2157|Archaea,2XT3X@28890|Euryarchaeota,23QA9@183939|Methanococci	183939|Methanococci	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Pyr_redox_2
PYH3_k127_5513506_0	1094980.Mpsy_2951	3.641e-144	486.0	COG1148@1|root,COG1908@1|root,arCOG02235@2157|Archaea,arCOG02476@2157|Archaea,2XT3X@28890|Euryarchaeota,2N9AI@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	hdrA-2	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_17,Fer4_7,Fer4_9,FlpD,Pyr_redox_2
PYH3_k127_5513506_3	370438.PTH_1005	1.152e-57	208.0	COG4656@1|root,COG4656@2|Bacteria,1TS9H@1239|Firmicutes,24DQ7@186801|Clostridia,260XZ@186807|Peptococcaceae	186801|Clostridia	C	PFAM Methylene-tetrahydrofolate reductase C terminal	metV	-	-	-	-	-	-	-	-	-	-	iHN637.CLJU_RS18525	MTHFR_C
PYH3_k127_5513506_2	2325.TKV_c19880	4.794e-62	224.0	COG0685@1|root,COG0685@2|Bacteria,1UHX4@1239|Firmicutes,25E62@186801|Clostridia,42FH6@68295|Thermoanaerobacterales	186801|Clostridia	C	Methylenetetrahydrofolate reductase	metF	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
PYH3_k127_5513506_4	1123393.KB891326_gene81	1.305e-33	143.0	COG0177@1|root,COG0177@2|Bacteria,1N2HB@1224|Proteobacteria	1224|Proteobacteria	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_5513621_1	84751.XP_007881582.1	9.527e-14	81.0	COG1100@1|root,KOG0075@2759|Eukaryota,38F0Z@33154|Opisthokonta,3NWXM@4751|Fungi,3V0T5@5204|Basidiomycota,3N2RS@452284|Ustilaginomycotina	4751|Fungi	U	Signal recognition particle receptor beta subunit	-	-	-	ko:K07955	-	-	-	-	ko00000,ko04031,ko04131	-	-	-	Arf
PYH3_k127_5513621_0	1094980.Mpsy_0196	2.034e-38	153.0	COG1234@1|root,arCOG00500@2157|Archaea,2XTUD@28890|Euryarchaeota,2NAES@224756|Methanomicrobia	224756|Methanomicrobia	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
PYH3_k127_5606351_7	368408.Tpen_0332	5.702e-11	74.0	arCOG03119@1|root,arCOG03119@2157|Archaea,2XQUD@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
PYH3_k127_5606351_8	399549.Msed_2295	2.848e-05	49.0	COG1522@1|root,arCOG01117@2157|Archaea,2XR1K@28889|Crenarchaeota	28889|Crenarchaeota	K	PFAM regulatory protein AsnC Lrp family	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
PYH3_k127_5606351_1	1499967.BAYZ01000100_gene3466	3.315e-76	272.0	COG1208@1|root,COG1208@2|Bacteria	2|Bacteria	JM	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon	rffH	-	2.3.1.157,2.7.7.13,2.7.7.23,2.7.7.24,5.4.2.8	ko:K00973,ko:K04042,ko:K16881	ko00051,ko00520,ko00521,ko00523,ko00525,ko01100,ko01110,ko01130,map00051,map00520,map00521,map00523,map00525,map01100,map01110,map01130	M00114,M00362,M00793	R00416,R00885,R01818,R02328,R05332	RC00002,RC00004,RC00166,RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
PYH3_k127_5606351_4	868131.MSWAN_1950	4.212e-60	225.0	COG0595@1|root,arCOG00547@2157|Archaea,2XTIB@28890|Euryarchaeota,23PHA@183925|Methanobacteria	183925|Methanobacteria	J	PFAM RNA-metabolising metallo-beta-lactamase	-	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B_2,RMMBL
PYH3_k127_5606351_6	565033.GACE_0105	1.429e-12	75.0	COG3270@1|root,arCOG02285@2157|Archaea,2XZD7@28890|Euryarchaeota,246DY@183980|Archaeoglobi	183980|Archaeoglobi	J	RNA-binding PUA-like domain of methyltransferase RsmF	-	-	-	-	-	-	-	-	-	-	-	-	Methyltranf_PUA
PYH3_k127_5606351_3	374847.Kcr_1076	2.003e-68	244.0	COG0144@1|root,arCOG00973@2157|Archaea	2157|Archaea	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family	cna	GO:0000049,GO:0001510,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016427,GO:0016428,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0140098,GO:0140101,GO:1901360,GO:1901363	-	ko:K22446	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltr_RsmB-F,Methyltr_RsmF_N
PYH3_k127_5606351_2	1205680.CAKO01000008_gene4203	2.658e-70	253.0	COG3616@1|root,COG3616@2|Bacteria,1N2SF@1224|Proteobacteria,2VFY5@28211|Alphaproteobacteria,2JRKP@204441|Rhodospirillales	204441|Rhodospirillales	E	Putative serine dehydratase domain	-	-	-	-	-	-	-	-	-	-	-	-	Ala_racemase_N,D-ser_dehydrat
PYH3_k127_5606351_0	1283300.ATXB01000001_gene2238	8.346e-98	329.0	COG0826@1|root,COG0826@2|Bacteria,1RHM0@1224|Proteobacteria	1224|Proteobacteria	O	peptidase U32	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_5606351_5	1125863.JAFN01000001_gene2756	2.144e-52	194.0	COG0329@1|root,COG0329@2|Bacteria,1MUCM@1224|Proteobacteria,42M0X@68525|delta/epsilon subdivisions,2WK4D@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
PYH3_k127_562265_5	342949.PNA2_1913	8.975e-13	77.0	COG0206@1|root,arCOG02202@2157|Archaea,2XTM7@28890|Euryarchaeota,243QG@183968|Thermococci	183968|Thermococci	D	Involved in cell shape control	cetZ	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K22222	-	-	-	-	ko00000,ko04812	-	-	-	Tubulin
PYH3_k127_562265_3	1151117.AJLF01000001_gene1330	4.067e-62	225.0	COG0024@1|root,arCOG01001@2157|Archaea,2XT8G@28890|Euryarchaeota,242WX@183968|Thermococci	183968|Thermococci	E	Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val)	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
PYH3_k127_562265_0	604354.TSIB_0175	8.522e-93	321.0	COG0624@1|root,arCOG01107@2157|Archaea,2Y315@28890|Euryarchaeota,242ZX@183968|Thermococci	183968|Thermococci	E	Peptidase family M20/M25/M40	-	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	Peptidase_M20
PYH3_k127_562265_6	1118054.CAGW01000063_gene2154	3.854e-10	72.0	COG0477@1|root,COG2814@2|Bacteria,1TS6K@1239|Firmicutes,4HB1V@91061|Bacilli,26RFG@186822|Paenibacillaceae	91061|Bacilli	EGP	Permeases of the major facilitator superfamily	tetA_3	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like,Sugar_tr
PYH3_k127_562265_1	529709.PYCH_02270	3.306e-89	308.0	COG0112@1|root,arCOG00070@2157|Archaea,2XU0H@28890|Euryarchaeota,242QX@183968|Thermococci	183968|Thermococci	E	Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
PYH3_k127_562265_4	7897.ENSLACP00000015549	1.323e-17	90.0	COG2012@1|root,KOG3218@2759|Eukaryota,398T1@33154|Opisthokonta,3BAP2@33208|Metazoa,3D1KQ@33213|Bilateria,4865W@7711|Chordata,4927C@7742|Vertebrata	33208|Metazoa	K	DNA-directed RNA polymerases I, II, and III subunit	POLR2E	GO:0000375,GO:0000377,GO:0000398,GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005665,GO:0005666,GO:0005730,GO:0005736,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006283,GO:0006289,GO:0006351,GO:0006352,GO:0006353,GO:0006354,GO:0006360,GO:0006361,GO:0006363,GO:0006366,GO:0006367,GO:0006368,GO:0006370,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0007165,GO:0007166,GO:0007167,GO:0007169,GO:0008150,GO:0008152,GO:0008380,GO:0008543,GO:0009058,GO:0009059,GO:0009301,GO:0009452,GO:0009719,GO:0009893,GO:0009987,GO:0010033,GO:0010467,GO:0010468,GO:0010604,GO:0010628,GO:0016070,GO:0016071,GO:0016073,GO:0016591,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019222,GO:0019438,GO:0023052,GO:0030880,GO:0031974,GO:0031981,GO:0032774,GO:0032991,GO:0033554,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0034660,GO:0036260,GO:0040029,GO:0042221,GO:0042795,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044344,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044451,GO:0044452,GO:0044464,GO:0045815,GO:0046483,GO:0048518,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055029,GO:0060147,GO:0060255,GO:0060964,GO:0060966,GO:0060968,GO:0061695,GO:0065007,GO:0070013,GO:0070848,GO:0070887,GO:0071310,GO:0071363,GO:0071495,GO:0071704,GO:0071774,GO:0090304,GO:0097659,GO:0097747,GO:0098781,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234	-	ko:K03013	ko00230,ko00240,ko01100,ko03020,ko04623,ko05016,ko05169,map00230,map00240,map01100,map03020,map04623,map05016,map05169	M00180,M00181,M00182	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko03021,ko03400	-	-	-	RNA_pol_Rpb5_C,RNA_pol_Rpb5_N
PYH3_k127_562265_2	935948.KE386495_gene1069	1.205e-62	227.0	COG0524@1|root,COG0524@2|Bacteria,1TPGM@1239|Firmicutes,247M1@186801|Clostridia,42GEV@68295|Thermoanaerobacterales	186801|Clostridia	H	PFAM PfkB domain protein	-	-	2.7.1.4	ko:K00847	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100	-	R00760,R00867,R03920	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
PYH3_k127_562265_7	1121405.dsmv_1718	5.617e-07	61.0	COG1234@1|root,COG1234@2|Bacteria,1PE64@1224|Proteobacteria,42RZR@68525|delta/epsilon subdivisions,2WMCC@28221|Deltaproteobacteria,2MIZZ@213118|Desulfobacterales	28221|Deltaproteobacteria	S	beta-lactamase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
PYH3_k127_5670695_3	1128398.Curi_c06420	3.451e-17	88.0	COG3945@1|root,COG3945@2|Bacteria,1V3TS@1239|Firmicutes,24HUR@186801|Clostridia,269E4@186813|unclassified Clostridiales	186801|Clostridia	S	Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
PYH3_k127_5670695_5	1260251.SPISAL_03625	0.0007204	44.0	COG0396@1|root,COG0396@2|Bacteria,1MUGK@1224|Proteobacteria,1RPFE@1236|Gammaproteobacteria,1WWC1@135613|Chromatiales	135613|Chromatiales	O	TIGRFAM FeS assembly ATPase SufC	-	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
PYH3_k127_5670695_0	1274524.BSONL12_20460	1.036e-42	166.0	COG0500@1|root,COG2226@2|Bacteria,1TR6N@1239|Firmicutes,4HEMY@91061|Bacilli,1ZRG7@1386|Bacillus	91061|Bacilli	Q	Methionine biosynthesis protein MetW	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
PYH3_k127_5670695_1	1054213.HMPREF9946_04468	4.719e-32	137.0	COG0596@1|root,COG0596@2|Bacteria,1Q4C8@1224|Proteobacteria	1224|Proteobacteria	S	alpha, beta	MA20_23630	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
PYH3_k127_5670695_2	460265.Mnod_1507	1.412e-17	97.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2TS14@28211|Alphaproteobacteria,1JUDI@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	PFAM extracellular solute-binding protein family 5	MA20_19540	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
PYH3_k127_5670695_4	710687.KI912270_gene4400	2.13e-15	90.0	COG0747@1|root,COG0747@2|Bacteria,2GNKN@201174|Actinobacteria,23EV8@1762|Mycobacteriaceae	201174|Actinobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
PYH3_k127_5716801_1	946362.XP_004987538.1	2.458e-34	139.0	KOG0094@1|root,KOG0094@2759|Eukaryota,38CQH@33154|Opisthokonta	33154|Opisthokonta	U	retrograde vesicle-mediated transport, Golgi to ER	RAB41	GO:0000003,GO:0000138,GO:0000139,GO:0000166,GO:0000226,GO:0000578,GO:0000902,GO:0000904,GO:0001654,GO:0001745,GO:0001751,GO:0001754,GO:0001882,GO:0001883,GO:0003002,GO:0003006,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005794,GO:0005795,GO:0006403,GO:0006810,GO:0006887,GO:0006890,GO:0006891,GO:0006928,GO:0006935,GO:0006950,GO:0006952,GO:0006996,GO:0007010,GO:0007017,GO:0007028,GO:0007154,GO:0007163,GO:0007165,GO:0007264,GO:0007265,GO:0007275,GO:0007276,GO:0007281,GO:0007292,GO:0007293,GO:0007308,GO:0007309,GO:0007314,GO:0007315,GO:0007316,GO:0007350,GO:0007351,GO:0007389,GO:0007399,GO:0007409,GO:0007411,GO:0007423,GO:0007602,GO:0007610,GO:0007626,GO:0007638,GO:0008103,GO:0008104,GO:0008150,GO:0008298,GO:0008344,GO:0008358,GO:0008595,GO:0009314,GO:0009416,GO:0009581,GO:0009582,GO:0009583,GO:0009605,GO:0009607,GO:0009612,GO:0009620,GO:0009628,GO:0009653,GO:0009790,GO:0009798,GO:0009880,GO:0009887,GO:0009948,GO:0009952,GO:0009966,GO:0009987,GO:0009994,GO:0010469,GO:0010646,GO:0012505,GO:0016020,GO:0016043,GO:0016192,GO:0016197,GO:0016325,GO:0016462,GO:0016482,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019094,GO:0019953,GO:0021700,GO:0022008,GO:0022412,GO:0022414,GO:0022607,GO:0022898,GO:0023051,GO:0023052,GO:0030030,GO:0030154,GO:0030182,GO:0030534,GO:0030951,GO:0030952,GO:0031090,GO:0031175,GO:0031410,GO:0031647,GO:0031982,GO:0031984,GO:0031985,GO:0032409,GO:0032412,GO:0032482,GO:0032501,GO:0032502,GO:0032504,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032879,GO:0032940,GO:0032989,GO:0032990,GO:0033036,GO:0034498,GO:0034613,GO:0034762,GO:0034765,GO:0035282,GO:0035418,GO:0035556,GO:0035639,GO:0036094,GO:0040011,GO:0042051,GO:0042147,GO:0042221,GO:0042330,GO:0042391,GO:0042461,GO:0042462,GO:0043167,GO:0043168,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043269,GO:0044085,GO:0044422,GO:0044424,GO:0044431,GO:0044444,GO:0044446,GO:0044464,GO:0044703,GO:0045451,GO:0045466,GO:0045467,GO:0046530,GO:0046903,GO:0046907,GO:0048193,GO:0048468,GO:0048469,GO:0048477,GO:0048513,GO:0048583,GO:0048592,GO:0048599,GO:0048609,GO:0048646,GO:0048666,GO:0048667,GO:0048699,GO:0048731,GO:0048749,GO:0048812,GO:0048856,GO:0048858,GO:0048869,GO:0050789,GO:0050794,GO:0050821,GO:0050832,GO:0050896,GO:0051049,GO:0051179,GO:0051234,GO:0051606,GO:0051641,GO:0051649,GO:0051704,GO:0051707,GO:0051716,GO:0060078,GO:0060810,GO:0060811,GO:0061564,GO:0065007,GO:0065008,GO:0065009,GO:0070727,GO:0071840,GO:0072657,GO:0090596,GO:0097159,GO:0097367,GO:0097485,GO:0097708,GO:0098542,GO:0098588,GO:0098791,GO:0099601,GO:0120036,GO:0120039,GO:1900449,GO:1901265,GO:1901363,GO:1903539,GO:1904062,GO:1990778,GO:2000311,GO:2001257	-	ko:K07893,ko:K07896	-	-	-	-	ko00000,ko04031,ko04131,ko04147	-	-	-	Ras
PYH3_k127_5716801_0	555088.DealDRAFT_1878	4.002e-293	913.0	COG0365@1|root,COG0365@2|Bacteria,1TQTI@1239|Firmicutes	1239|Firmicutes	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
PYH3_k127_5716801_2	215803.DB30_3800	4.097e-16	90.0	COG3509@1|root,COG3509@2|Bacteria,1MXUI@1224|Proteobacteria,430Q8@68525|delta/epsilon subdivisions,2WVYQ@28221|Deltaproteobacteria,2YU06@29|Myxococcales	28221|Deltaproteobacteria	Q	Esterase PHB depolymerase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase_phd
PYH3_k127_5722743_2	351160.RCIX947	9.178e-24	102.0	COG1926@1|root,arCOG00041@2157|Archaea,2XWHP@28890|Euryarchaeota,2N9V9@224756|Methanomicrobia	224756|Methanomicrobia	F	Phosphoribosyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
PYH3_k127_5722743_4	1340493.JNIF01000004_gene1054	7.988e-15	85.0	COG3577@1|root,COG3577@2|Bacteria	2|Bacteria	S	aspartic-type endopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Asp_protease_2,TPR_16,TPR_8,gag-asp_proteas
PYH3_k127_5722743_3	765912.Thimo_1125	7.122e-21	96.0	COG2146@1|root,COG2146@2|Bacteria	2|Bacteria	P	nitrite reductase [NAD(P)H] activity	-	-	1.7.1.15	ko:K00363,ko:K05710	ko00360,ko00910,ko01120,ko01220,map00360,map00910,map01120,map01220	M00530,M00545	R00787,R06782,R06783	RC00098,RC00176	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	Ferric_reduct,Rieske,Rieske_2
PYH3_k127_5722743_1	706587.Desti_1548	2.392e-38	154.0	COG1600@1|root,COG1600@2|Bacteria	2|Bacteria	C	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)	-	-	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1730,Fer4_16,HEAT_2
PYH3_k127_5722743_0	660470.Theba_2521	1.696e-39	152.0	2DNQ8@1|root,32YJ3@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_5722743_5	67267.JNXT01000072_gene3058	9.226e-08	61.0	COG0500@1|root,COG2226@2|Bacteria,2I1M7@201174|Actinobacteria	201174|Actinobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
PYH3_k127_574579_2	429009.Adeg_1635	3.76e-32	131.0	COG0171@1|root,COG0171@2|Bacteria,1TQ38@1239|Firmicutes,2484Z@186801|Clostridia,42G09@68295|Thermoanaerobacterales	186801|Clostridia	F	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source	nadE	-	6.3.1.5	ko:K01916	ko00760,ko01100,map00760,map01100	M00115	R00189	RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	NAD_synthase
PYH3_k127_574579_1	1220534.B655_0469	1.21e-65	235.0	COG0157@1|root,arCOG01482@2157|Archaea,2XTTY@28890|Euryarchaeota,23NNA@183925|Methanobacteria	183925|Methanobacteria	H	Involved in the catabolism of quinolinic acid (QA)	nadC	-	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	-	QRPTase_C,QRPTase_N
PYH3_k127_574579_0	1220534.B655_1873	3.707e-84	289.0	COG0379@1|root,arCOG04459@2157|Archaea,2XUGT@28890|Euryarchaeota,23NN6@183925|Methanobacteria	183925|Methanobacteria	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	-	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	-	NadA
PYH3_k127_5768366_0	1122138.AQUZ01000001_gene1800	6.47e-110	383.0	COG1874@1|root,COG1874@2|Bacteria,2GIUX@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase 35 family	-	-	3.2.1.23	ko:K12308	ko00052,map00052	-	R01105	RC00452	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_35
PYH3_k127_5768366_1	240016.ABIZ01000001_gene5281	3.487e-08	59.0	COG3871@1|root,COG3871@2|Bacteria,46VIW@74201|Verrucomicrobia,2IVPR@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Pyridoxamine 5'-phosphate oxidase like	-	-	-	-	-	-	-	-	-	-	-	-	Pyrid_ox_like
PYH3_k127_5774361_1	562970.Btus_1766	1.251e-41	157.0	COG0509@1|root,COG0509@2|Bacteria,1V6WV@1239|Firmicutes,4HIMA@91061|Bacilli,279UB@186823|Alicyclobacillaceae	91061|Bacilli	E	Is also involved in protein lipoylation via its role as an octanoyl lipoyl carrier protein intermediate	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
PYH3_k127_5774361_0	34506.KOG2292.13	4.099e-55	212.0	COG1287@1|root,KOG2292@2759|Eukaryota,38D8E@33154|Opisthokonta,3B9KS@33208|Metazoa,3CXTS@33213|Bilateria,40FDE@6231|Nematoda,1KYNS@119089|Chromadorea,40UV5@6236|Rhabditida	33208|Metazoa	O	Oligosaccharyl transferase STT3 subunit	STT3B	GO:0003674,GO:0003824,GO:0004576,GO:0004579,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005789,GO:0006464,GO:0006486,GO:0006487,GO:0006508,GO:0006511,GO:0006516,GO:0006807,GO:0006950,GO:0006986,GO:0008150,GO:0008152,GO:0008250,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009987,GO:0010033,GO:0010243,GO:0010498,GO:0012505,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0018193,GO:0018196,GO:0018279,GO:0019538,GO:0019941,GO:0030163,GO:0030433,GO:0031984,GO:0032991,GO:0033554,GO:0034645,GO:0034976,GO:0035966,GO:0036211,GO:0036503,GO:0042175,GO:0042221,GO:0043161,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0043413,GO:0043632,GO:0043686,GO:0043687,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0050896,GO:0051603,GO:0051716,GO:0070085,GO:0071704,GO:0098796,GO:0098827,GO:1901135,GO:1901136,GO:1901137,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901698,GO:1902494,GO:1990234	2.4.99.18	ko:K07151	ko00510,ko00513,ko01100,ko04141,map00510,map00513,map01100,map04141	M00072	R04216,R05976	RC00005,RC00482	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT66	-	STT3
PYH3_k127_5792926_1	634498.mru_1747	1.725e-29	120.0	COG0673@1|root,arCOG01622@2157|Archaea,2XTZY@28890|Euryarchaeota,23NSJ@183925|Methanobacteria	183925|Methanobacteria	S	PFAM Oxidoreductase	-	-	1.1.1.374	ko:K18855	-	-	-	-	ko00000,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
PYH3_k127_5792926_3	362976.HQ_2987A	1.009e-18	96.0	COG1378@1|root,arCOG02037@2157|Archaea,2XUMX@28890|Euryarchaeota,23TM3@183963|Halobacteria	183963|Halobacteria	K	transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	TrmB
PYH3_k127_5792926_0	368408.Tpen_0412	5.623e-45	181.0	COG0472@1|root,arCOG03199@2157|Archaea,2XPXP@28889|Crenarchaeota	28889|Crenarchaeota	M	PFAM Glycosyl transferase family 4	-	-	2.7.8.15	ko:K01001	ko00510,ko01100,map00510,map01100	M00055	R05969	RC00002	ko00000,ko00001,ko00002,ko01000,ko01003	-	-	-	Glycos_transf_4
PYH3_k127_5792926_2	386456.JQKN01000002_gene2894	9.649e-22	105.0	COG1193@1|root,arCOG02895@2157|Archaea,2XT51@28890|Euryarchaeota,23NQB@183925|Methanobacteria	183925|Methanobacteria	L	Has ATPase and non-specific DNA-binding activities	mutS2	-	-	ko:K07456	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	HHH_5,MutS_V
PYH3_k127_5821142_2	1515615.HQ41_02785	4.085e-35	151.0	COG1470@1|root,COG1470@2|Bacteria	2|Bacteria	S	cell adhesion involved in biofilm formation	-	-	-	-	-	-	-	-	-	-	-	-	Gram_pos_anchor,Peptidase_M73
PYH3_k127_5821142_0	456442.Mboo_2311	1.117e-99	337.0	COG1405@1|root,arCOG01981@2157|Archaea,2XT0Z@28890|Euryarchaeota,2N96C@224756|Methanomicrobia	224756|Methanomicrobia	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	tfb	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
PYH3_k127_5821142_1	335541.Swol_0417	9.238e-59	217.0	COG0407@1|root,COG0407@2|Bacteria,1USM0@1239|Firmicutes,248G3@186801|Clostridia,42K8G@68298|Syntrophomonadaceae	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
PYH3_k127_5821142_3	1137271.AZUM01000004_gene4276	0.0001462	53.0	COG1807@1|root,COG1807@2|Bacteria,2IEB9@201174|Actinobacteria,4E27D@85010|Pseudonocardiales	201174|Actinobacteria	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_5825644_3	944565.HMPREF9127_0768	6.756e-23	106.0	290DM@1|root,2ZN2Z@2|Bacteria	2|Bacteria	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
PYH3_k127_5825644_0	1499967.BAYZ01000013_gene6463	3.972e-106	351.0	COG0667@1|root,COG0667@2|Bacteria	2|Bacteria	C	Aldo Keto reductase	-	-	-	ko:K07079	-	-	-	-	ko00000	-	-	-	Aldo_ket_red
PYH3_k127_5825644_1	374847.Kcr_1036	1.443e-99	341.0	COG1960@1|root,arCOG04310@2157|Archaea	2157|Archaea	C	PFAM acyl-CoA dehydrogenase domain protein	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
PYH3_k127_5825644_6	1166018.FAES_4374	8.324e-05	53.0	COG2373@1|root,COG4932@1|root,COG2373@2|Bacteria,COG4932@2|Bacteria,4PKCH@976|Bacteroidetes,47YME@768503|Cytophagia	976|Bacteroidetes	M	SdrD B-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,DUF11,SdrD_B
PYH3_k127_5825644_7	34349.G7E0W6	0.0004795	50.0	COG0670@1|root,KOG2322@2759|Eukaryota,39TQG@33154|Opisthokonta,3NVYX@4751|Fungi,3V0FS@5204|Basidiomycota,2YDS6@29000|Pucciniomycotina	4751|Fungi	T	Inhibitor of apoptosis-promoting Bax1	-	GO:0000322,GO:0000323,GO:0000324,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005773,GO:0005783,GO:0005789,GO:0006915,GO:0006950,GO:0006986,GO:0007154,GO:0007165,GO:0008150,GO:0008219,GO:0009987,GO:0010033,GO:0012501,GO:0012505,GO:0016020,GO:0016021,GO:0019722,GO:0019932,GO:0023052,GO:0030176,GO:0030968,GO:0031224,GO:0031227,GO:0031984,GO:0033554,GO:0034620,GO:0034976,GO:0035556,GO:0035966,GO:0035967,GO:0042175,GO:0042221,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070887,GO:0071310,GO:0098827	-	ko:K06890	-	-	-	-	ko00000	-	-	-	Bax1-I
PYH3_k127_5825644_4	1122135.KB893135_gene965	1.038e-16	89.0	COG0500@1|root,COG2226@2|Bacteria,1PHI5@1224|Proteobacteria,2UKZQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
PYH3_k127_5825644_5	1267535.KB906767_gene391	2.016e-14	80.0	COG0346@1|root,COG2208@1|root,COG0346@2|Bacteria,COG2208@2|Bacteria	2|Bacteria	T	phosphoserine phosphatase activity	icfG	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	GAF_2,Glyoxalase,HAMP,SpoIIE
PYH3_k127_5825644_2	555088.DealDRAFT_1432	1.268e-88	301.0	COG2025@1|root,COG2025@2|Bacteria,1TPC8@1239|Firmicutes,247NF@186801|Clostridia,42KAR@68298|Syntrophomonadaceae	186801|Clostridia	C	Electron transfer flavoprotein, alpha subunit	fixB	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha,Fer4,Fer4_6,Fer4_7
PYH3_k127_5827315_0	391623.TERMP_00239	1.463e-139	451.0	COG1003@1|root,arCOG00076@2157|Archaea,2XT3V@28890|Euryarchaeota,242MV@183968|Thermococci	183968|Thermococci	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPB	-	1.4.4.2	ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
PYH3_k127_5827315_2	1220534.B655_1957	1.847e-79	273.0	COG0090@1|root,arCOG04067@2157|Archaea,2XTCS@28890|Euryarchaeota,23NS8@183925|Methanobacteria	183925|Methanobacteria	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rpl2	-	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
PYH3_k127_5827315_4	529709.PYCH_01390	1.576e-26	112.0	COG0089@1|root,arCOG04072@2157|Archaea,2XYPG@28890|Euryarchaeota,244AA@183968|Thermococci	183968|Thermococci	J	Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome	rpl23	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
PYH3_k127_5827315_3	1220534.B655_1959	2.649e-68	240.0	COG0469@1|root,arCOG04071@2157|Archaea,2XTXX@28890|Euryarchaeota,23NJ7@183925|Methanobacteria	183925|Methanobacteria	J	50S ribosomal protein L4	rpl4	-	-	ko:K02930	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
PYH3_k127_5827315_1	634498.mru_0851	3.525e-89	307.0	COG0087@1|root,arCOG04070@2157|Archaea,2XT9B@28890|Euryarchaeota,23NMA@183925|Methanobacteria	183925|Methanobacteria	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rpl3	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
PYH3_k127_5827315_5	1094980.Mpsy_2319	3.694e-12	73.0	COG1371@1|root,arCOG04055@2157|Archaea,2XXRX@28890|Euryarchaeota,2NA1Z@224756|Methanomicrobia	224756|Methanomicrobia	S	Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently	-	-	-	-	-	-	-	-	-	-	-	-	Archease
PYH3_k127_5835312_0	68170.KL590471_gene4148	0.000186	48.0	COG1522@1|root,COG1522@2|Bacteria,2GKP4@201174|Actinobacteria,4E18P@85010|Pseudonocardiales	201174|Actinobacteria	K	AsnC-type helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
PYH3_k127_5835312_1	1071085.KK033114_gene1301	0.0004185	47.0	COG1522@1|root,arCOG01117@2157|Archaea,2Y03Q@28890|Euryarchaeota,23XKC@183963|Halobacteria	183963|Halobacteria	K	COG1522 Transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
PYH3_k127_5837421_0	1151122.AQYD01000007_gene1217	5.833e-69	248.0	COG4409@1|root,COG4409@2|Bacteria,2GKYI@201174|Actinobacteria,4FRBW@85023|Microbacteriaceae	201174|Actinobacteria	G	Domain of unknown function (DUF4185)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4185
PYH3_k127_5837421_2	335543.Sfum_3263	1.084e-22	108.0	COG0500@1|root,COG2226@2|Bacteria,1RHDG@1224|Proteobacteria,42SD3@68525|delta/epsilon subdivisions,2WP6S@28221|Deltaproteobacteria,2MQPZ@213462|Syntrophobacterales	28221|Deltaproteobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
PYH3_k127_5837421_1	1239962.C943_02975	1.433e-67	236.0	COG0225@1|root,COG0225@2|Bacteria,4NMAJ@976|Bacteroidetes,47PB4@768503|Cytophagia	976|Bacteroidetes	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
PYH3_k127_5869127_4	572478.Vdis_0984	7.04e-29	122.0	arCOG05489@1|root,arCOG05489@2157|Archaea,2XQT5@28889|Crenarchaeota	28889|Crenarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_5869127_3	698757.Pogu_2328	3.43e-42	162.0	COG0125@1|root,arCOG01891@2157|Archaea,2XQB7@28889|Crenarchaeota	28889|Crenarchaeota	F	PFAM thymidylate kinase	tmk	GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
PYH3_k127_5869127_6	1123368.AUIS01000022_gene1042	1.592e-18	90.0	COG2018@1|root,COG2018@2|Bacteria,1RIQC@1224|Proteobacteria,1S65Z@1236|Gammaproteobacteria,2NCXX@225057|Acidithiobacillales	225057|Acidithiobacillales	S	Roadblock LC7 family protein	-	-	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
PYH3_k127_5869127_2	1042877.GQS_03420	5.6e-71	252.0	COG0024@1|root,arCOG01001@2157|Archaea,2XT8G@28890|Euryarchaeota,242WX@183968|Thermococci	183968|Thermococci	E	Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val)	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
PYH3_k127_5869127_0	1220534.B655_0179	1.489e-116	384.0	COG1405@1|root,arCOG01981@2157|Archaea,2XT0Z@28890|Euryarchaeota,23NWZ@183925|Methanobacteria	183925|Methanobacteria	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	tfb	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
PYH3_k127_5869127_5	999547.KI421500_gene565	6.851e-24	110.0	COG4912@1|root,COG4912@2|Bacteria,1NKDG@1224|Proteobacteria,2TU19@28211|Alphaproteobacteria,27ZRJ@191028|Leisingera	28211|Alphaproteobacteria	L	DNA alkylation repair enzyme	-	-	-	-	-	-	-	-	-	-	-	-	DNA_alkylation
PYH3_k127_5869127_1	96561.Dole_0337	1.211e-78	268.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42M5F@68525|delta/epsilon subdivisions,2WISF@28221|Deltaproteobacteria,2MI8R@213118|Desulfobacterales	28221|Deltaproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
PYH3_k127_5871670_4	374847.Kcr_0011	0.0002743	47.0	arCOG03714@1|root,arCOG03714@2157|Archaea	2157|Archaea	F	ATP cone domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-cone,Mrr_cat
PYH3_k127_5871670_3	1405296.Q499_0429	6.586e-05	51.0	COG1327@1|root,COG1327@2|Bacteria,2JG1D@204428|Chlamydiae	204428|Chlamydiae	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	-	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
PYH3_k127_5871670_0	439235.Dalk_4041	1.245e-127	424.0	COG0277@1|root,COG0277@2|Bacteria,1MY08@1224|Proteobacteria,42Q28@68525|delta/epsilon subdivisions,2WMZ9@28221|Deltaproteobacteria,2MPEE@213118|Desulfobacterales	28221|Deltaproteobacteria	C	FAD binding domain	pcmI	-	1.17.99.1	ko:K05797	ko00623,ko01100,ko01120,map00623,map01100,map01120	-	R02675,R11194	RC00769	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
PYH3_k127_5871670_1	903818.KI912269_gene284	7.021e-102	352.0	COG0247@1|root,COG0247@2|Bacteria,3Y3RK@57723|Acidobacteria	57723|Acidobacteria	C	Cysteine-rich domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
PYH3_k127_5871670_2	903818.KI912269_gene285	3.056e-30	126.0	COG0277@1|root,COG0277@2|Bacteria	2|Bacteria	C	FAD linked oxidase domain protein	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	BBE,FAD_binding_4
PYH3_k127_5873070_0	572478.Vdis_1836	1.419e-214	696.0	COG0417@1|root,arCOG15272@2157|Archaea,2XPPT@28889|Crenarchaeota	28889|Crenarchaeota	L	SMART DNA-directed DNA polymerase B	dpo1	-	2.7.7.7	ko:K02319	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_pol_B,DNA_pol_B_exo1
PYH3_k127_5873070_2	756067.MicvaDRAFT_2466	5.106e-05	55.0	COG1649@1|root,COG1649@2|Bacteria,1G42C@1117|Cyanobacteria,1H72B@1150|Oscillatoriales	1117|Cyanobacteria	S	Glycosyl hydrolase-like 10	-	-	-	-	-	-	-	-	-	-	-	-	GHL10
PYH3_k127_5873070_4	647113.Metok_1122	0.0006577	50.0	COG4008@1|root,arCOG04853@2157|Archaea,2XX3S@28890|Euryarchaeota,23QY0@183939|Methanococci	183939|Methanococci	K	TIGRFAM methanogenesis marker protein 9	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_5873070_3	1236689.MMALV_04200	0.0001189	50.0	arCOG10807@1|root,arCOG10807@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_5873070_1	985053.VMUT_1561	9.081e-173	564.0	COG0495@1|root,arCOG00809@2157|Archaea,2XPP2@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1
PYH3_k127_5970539_1	1112204.GPOL_c15200	2.126e-29	129.0	2ERKW@1|root,33J6D@2|Bacteria,2I7F1@201174|Actinobacteria,4GGVG@85026|Gordoniaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_5970539_2	1268622.AVS7_00919	4.418e-17	94.0	28IVP@1|root,2Z8U1@2|Bacteria,1QWF9@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_5970539_0	1382306.JNIM01000001_gene2330	1.408e-227	721.0	COG0365@1|root,COG0365@2|Bacteria,2G83G@200795|Chloroflexi	200795|Chloroflexi	I	Acetyl-coenzyme A synthetase N-terminus	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
PYH3_k127_6015220_2	880073.Calab_1834	1.197e-20	104.0	COG4285@1|root,COG4285@2|Bacteria	2|Bacteria	S	Biotin-protein ligase, N terminal	CP_0643	-	-	-	-	-	-	-	-	-	-	-	BPL_N
PYH3_k127_6015220_1	690850.Desaf_0247	4.258e-40	161.0	COG0697@1|root,COG0697@2|Bacteria,1NCEQ@1224|Proteobacteria,43AZZ@68525|delta/epsilon subdivisions,2X6E2@28221|Deltaproteobacteria,2MH1V@213115|Desulfovibrionales	28221|Deltaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
PYH3_k127_6015220_0	330214.NIDE1914	3.808e-76	263.0	COG1194@1|root,COG1194@2|Bacteria,3J160@40117|Nitrospirae	40117|Nitrospirae	L	FES	-	-	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
PYH3_k127_6015220_3	1174504.AJTN02000250_gene2947	4.239e-07	62.0	COG0477@1|root,COG2814@2|Bacteria,1TS6K@1239|Firmicutes,4HB1V@91061|Bacilli,1ZB90@1386|Bacillus	91061|Bacilli	EGP	COG0477 Permeases of the major facilitator superfamily	tetA_3	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like,Sugar_tr
PYH3_k127_606825_0	269797.Mbar_A0214	4.627e-81	282.0	COG1363@1|root,arCOG01518@2157|Archaea,2XT3M@28890|Euryarchaeota,2N94F@224756|Methanomicrobia	224756|Methanomicrobia	G	peptidase M42 family protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M42
PYH3_k127_606825_3	1307759.JOMJ01000004_gene2488	1.089e-07	64.0	COG3267@1|root,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,42NNX@68525|delta/epsilon subdivisions,2WJ9P@28221|Deltaproteobacteria,2M9N2@213115|Desulfovibrionales	28221|Deltaproteobacteria	U	secretion ATPase, PEP-CTERM locus subfamily	-	-	-	ko:K02450	-	M00331	-	-	ko00000,ko00002,ko02044	9.B.42	-	-	AAA_22
PYH3_k127_606825_1	8083.ENSXMAP00000017402	2.278e-46	174.0	KOG0093@1|root,KOG0093@2759|Eukaryota,3AI64@33154|Opisthokonta,3BZ5P@33208|Metazoa,3DEVB@33213|Bilateria,48HC6@7711|Chordata,49G11@7742|Vertebrata,4A6JY@7898|Actinopterygii	33208|Metazoa	U	RAB3D, member RAS oncogene family, a	-	-	-	ko:K07884	ko04972,map04972	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	Ras
PYH3_k127_606825_2	945713.IALB_0147	6.661e-29	129.0	COG2234@1|root,COG4412@1|root,COG2234@2|Bacteria,COG4412@2|Bacteria	2|Bacteria	S	peptidase activity, acting on L-amino acid peptides	-	-	3.4.11.10,3.4.21.50	ko:K01337,ko:K05994,ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF4968,DUF5110,F5_F8_type_C,Glyco_hydro_31,PA,Peptidase_M28,Peptidase_M6,Peptidase_S8,W_rich_C
PYH3_k127_6085016_0	192952.MM_2535	5.445e-105	357.0	COG1258@1|root,arCOG01015@2157|Archaea,2XTTX@28890|Euryarchaeota,2N98Y@224756|Methanomicrobia	224756|Methanomicrobia	J	Responsible for synthesis of pseudouridine from uracil- 54 and uracil-55 in the psi GC loop of transfer RNAs	pus10	-	5.4.99.25	ko:K07583	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	THUMP
PYH3_k127_6085016_3	273063.STK_04590	2.091e-25	109.0	COG2139@1|root,arCOG04129@2157|Archaea,2XQR1@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eL21 family	rpl21e	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02889	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21e
PYH3_k127_6085016_4	304371.MCP_0724	6.375e-06	54.0	COG1460@1|root,arCOG01016@2157|Archaea,2XXZX@28890|Euryarchaeota,2N9UM@224756|Methanomicrobia	224756|Methanomicrobia	K	PFAM RNA polymerase Rpb4	rpoF	-	2.7.7.6	ko:K03051	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb4
PYH3_k127_6085016_1	565033.GACE_1388	8.11e-58	207.0	COG1491@1|root,arCOG04130@2157|Archaea,2XXAI@28890|Euryarchaeota,246VN@183980|Archaeoglobi	183980|Archaeoglobi	J	Protein of unknown function (DUF655)	-	-	-	ko:K07572	-	-	-	-	ko00000	-	-	-	DUF655
PYH3_k127_6085016_2	195522.BD01_0297	5.835e-43	167.0	COG0030@1|root,arCOG04131@2157|Archaea,2XU1Q@28890|Euryarchaeota,242SR@183968|Thermococci	183968|Thermococci	J	Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
PYH3_k127_6180118_3	368408.Tpen_1033	9.136e-05	53.0	arCOG03776@1|root,arCOG03776@2157|Archaea,2XSKE@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM Zinc finger TFIIB-type domain protein	-	-	-	-	-	-	-	-	-	-	-	-	TF_Zn_Ribbon
PYH3_k127_6180118_2	490899.DKAM_0175	2.412e-13	77.0	arCOG05710@1|root,arCOG05710@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_6180118_1	368408.Tpen_1035	9.333e-78	271.0	arCOG01917@1|root,arCOG01917@2157|Archaea,2XSQD@28889|Crenarchaeota	28889|Crenarchaeota	S	SMART zinc finger, RanBP2-type	-	-	-	-	-	-	-	-	-	-	-	-	Band_7_1,UPF0547,zinc_ribbon_2
PYH3_k127_6180118_0	1267535.KB906767_gene4312	6.25e-78	265.0	COG2818@1|root,COG2818@2|Bacteria,3Y4NC@57723|Acidobacteria	57723|Acidobacteria	L	Methyladenine glycosylase	-	-	3.2.2.20	ko:K01246	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Adenine_glyco
PYH3_k127_6237799_3	517722.AEUE01000001_gene2555	3.594e-26	122.0	COG0438@1|root,COG0438@2|Bacteria,1PDR7@1224|Proteobacteria,2U1R4@28211|Alphaproteobacteria,2K0MZ@204457|Sphingomonadales	204457|Sphingomonadales	M	Glycosyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glycos_transf_1
PYH3_k127_6237799_1	1163730.FFONT_1027	5.96e-35	143.0	COG1047@1|root,arCOG00980@2157|Archaea,2XQ07@28889|Crenarchaeota	28889|Crenarchaeota	O	peptidyl-prolyl cis-trans isomerase	-	-	5.2.1.8	ko:K01802	-	-	-	-	ko00000,ko01000	-	-	-	FKBP_C
PYH3_k127_6237799_2	579137.Metvu_0671	2.584e-28	119.0	COG1860@1|root,arCOG04477@2157|Archaea,2XX8X@28890|Euryarchaeota,23QYT@183939|Methanococci	183939|Methanococci	S	Belongs to the UPF0179 family	-	-	-	ko:K09730	-	-	-	-	ko00000	-	-	-	UPF0179
PYH3_k127_6237799_0	386456.JQKN01000019_gene1316	1.224e-235	745.0	COG1782@1|root,arCOG00543@2157|Archaea,2XTIM@28890|Euryarchaeota,23NSS@183925|Methanobacteria	183925|Methanobacteria	S	Beta-Casp domain	-	-	-	ko:K07041	-	-	-	-	ko00000	-	-	-	Beta-Casp,KH_7,Lactamase_B_6,RMMBL
PYH3_k127_6237799_4	247490.KSU1_D0425	4.866e-14	77.0	COG2199@1|root,COG2227@1|root,COG2227@2|Bacteria,COG3706@2|Bacteria,2J2MA@203682|Planctomycetes	203682|Planctomycetes	H	Methionine biosynthesis protein MetW	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
PYH3_k127_6245702_0	373903.Hore_13850	2.274e-62	221.0	COG1573@1|root,COG1573@2|Bacteria,1V1SU@1239|Firmicutes,24E7B@186801|Clostridia	186801|Clostridia	L	Uracil DNA glycosylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	UDG
PYH3_k127_6245702_1	756272.Plabr_2740	9.476e-11	74.0	COG0389@1|root,COG0389@2|Bacteria,2IXYQ@203682|Planctomycetes	203682|Planctomycetes	L	Domain of unknown function (DUF4332)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4332
PYH3_k127_6275613_9	633148.Tagg_0988	3.885e-10	65.0	COG2092@1|root,arCOG01988@2157|Archaea,2XR49@28889|Crenarchaeota	28889|Crenarchaeota	J	Promotes the exchange of GDP for GTP in EF-1-alpha GDP, thus allowing the regeneration of EF-1-alpha GTP that could then be used to form the ternary complex EF-1-alpha GTP AAtRNA	ef1b	-	-	ko:K03232	-	-	-	-	ko00000,ko03012	-	-	-	EF1_GNE
PYH3_k127_6275613_0	694429.Pyrfu_0111	4.948e-281	883.0	COG0464@1|root,arCOG01308@2157|Archaea,2XPPI@28889|Crenarchaeota	28889|Crenarchaeota	O	Cell division protein 48 (CDC48), domain 2	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N,Vps4_C
PYH3_k127_6275613_11	633148.Tagg_0990	0.0001146	49.0	arCOG07192@1|root,arCOG07192@2157|Archaea,2XRB7@28889|Crenarchaeota	28889|Crenarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_6275613_3	572478.Vdis_2057	1.554e-53	197.0	COG0592@1|root,arCOG00488@2157|Archaea,2XQCF@28889|Crenarchaeota	28889|Crenarchaeota	L	Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication	pcn	GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006272,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0022616,GO:0030234,GO:0030337,GO:0032991,GO:0034641,GO:0034645,GO:0043170,GO:0043626,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0044796,GO:0046483,GO:0050790,GO:0065007,GO:0065009,GO:0071704,GO:0090304,GO:0098772,GO:1901360,GO:1901576	-	ko:K04802	ko03030,ko03410,ko03420,ko03430,ko04110,ko04530,ko05161,ko05166,map03030,map03410,map03420,map03430,map04110,map04530,map05161,map05166	M00295	-	-	ko00000,ko00001,ko00002,ko03032,ko03400	-	-	-	PCNA_C,PCNA_N
PYH3_k127_6275613_2	1041930.Mtc_2135	8.633e-56	209.0	COG2219@1|root,arCOG03013@2157|Archaea,2XTDT@28890|Euryarchaeota,2N9HY@224756|Methanomicrobia	224756|Methanomicrobia	L	Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair	priL	-	-	ko:K18882	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_primase_lrg
PYH3_k127_6275613_1	368408.Tpen_0622	1.063e-69	251.0	COG1467@1|root,arCOG04110@2157|Archaea,2XQI5@28889|Crenarchaeota	28889|Crenarchaeota	L	Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair	priS	GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0003896,GO:0003899,GO:0005488,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006269,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901363,GO:1901576	-	ko:K02683	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_primase_S
PYH3_k127_6275613_10	1229909.NSED_09580	6.755e-06	55.0	COG1711@1|root,arCOG00551@2157|Archaea,41SVQ@651137|Thaumarchaeota	651137|Thaumarchaeota	L	protein conserved in archaea	-	-	-	ko:K09723	-	-	-	-	ko00000,ko03032	-	-	-	-
PYH3_k127_6275613_6	415426.Hbut_1642	2.202e-31	124.0	COG1631@1|root,arCOG04109@2157|Archaea,2XQU0@28889|Crenarchaeota	28889|Crenarchaeota	J	binds to the 23S rRNA	rpl44e	-	-	ko:K02929	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L44
PYH3_k127_6275613_7	444157.Tneu_1686	8.44e-15	76.0	COG2051@1|root,arCOG04108@2157|Archaea,2XR0Y@28889|Crenarchaeota	28889|Crenarchaeota	J	PFAM ribosomal protein	rps27e	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02978	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S27e
PYH3_k127_6275613_4	573064.Mefer_0818	8.077e-51	190.0	COG1093@1|root,arCOG04107@2157|Archaea,2XTV0@28890|Euryarchaeota,23PZU@183939|Methanococci	183939|Methanococci	J	Translation initiation factor 2	eif2a	GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K03237	ko03013,ko04138,ko04140,ko04141,ko04210,ko04932,ko05160,ko05162,ko05164,ko05168,map03013,map04138,map04140,map04141,map04210,map04932,map05160,map05162,map05164,map05168	-	-	-	ko00000,ko00001,ko03012	-	-	-	EIF_2_alpha,S1
PYH3_k127_6275613_8	1183377.Py04_0822	7.101e-14	74.0	COG2260@1|root,arCOG00906@2157|Archaea,2Y1HX@28890|Euryarchaeota,244PG@183968|Thermococci	183968|Thermococci	J	more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA	nop10	-	-	ko:K11130	ko03008,map03008	M00425	-	-	ko00000,ko00001,ko00002,ko03009,ko03032	-	-	-	Nop10p
PYH3_k127_6275613_5	88036.EFJ19648	1.206e-41	175.0	COG1287@1|root,KOG2292@2759|Eukaryota,37M0F@33090|Viridiplantae,3G8TE@35493|Streptophyta	35493|Streptophyta	O	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit	STT3B	GO:0003674,GO:0003824,GO:0004576,GO:0004579,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005789,GO:0005886,GO:0006464,GO:0006486,GO:0006487,GO:0006807,GO:0008150,GO:0008152,GO:0008250,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009987,GO:0012505,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0018193,GO:0018196,GO:0018279,GO:0019538,GO:0031984,GO:0032991,GO:0034645,GO:0036211,GO:0042175,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0043413,GO:0043687,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0070085,GO:0071704,GO:0071944,GO:0098796,GO:0098827,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1902494,GO:1990234	2.4.99.18	ko:K07151	ko00510,ko00513,ko01100,ko04141,map00510,map00513,map01100,map04141	M00072	R04216,R05976	RC00005,RC00482	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT66	-	STT3
PYH3_k127_6286654_1	573064.Mefer_0614	5.159e-05	46.0	COG3640@1|root,arCOG00587@2157|Archaea,2XT61@28890|Euryarchaeota,23QPT@183939|Methanococci	183939|Methanococci	D	PFAM Cobyrinic acid a,c-diamide synthase	-	-	-	ko:K07321	-	-	-	-	ko00000	-	-	-	CbiA
PYH3_k127_6286654_0	1472716.KBK24_0101145	6.84e-17	96.0	COG1615@1|root,COG1615@2|Bacteria,1MZ5A@1224|Proteobacteria,2W1FV@28216|Betaproteobacteria,1K502@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Uncharacterised protein family (UPF0182)	-	-	-	ko:K09118	-	-	-	-	ko00000	-	-	-	UPF0182
PYH3_k127_6319327_1	591019.Shell_1602	1.946e-128	430.0	COG0480@1|root,arCOG01559@2157|Archaea,2XPV5@28889|Crenarchaeota	28889|Crenarchaeota	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03234	ko04152,ko04921,map04152,map04921	-	-	-	ko00000,ko00001,ko03012,ko04147	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
PYH3_k127_6319327_7	323259.Mhun_2828	3.835e-19	89.0	COG0480@1|root,arCOG01559@2157|Archaea,2XUMQ@28890|Euryarchaeota,2N9FS@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K03234	ko04152,ko04921,map04152,map04921	-	-	-	ko00000,ko00001,ko03012,ko04147	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
PYH3_k127_6319327_9	671065.MetMK1DRAFT_00022500	6.999e-09	70.0	COG0433@1|root,arCOG00286@2157|Archaea,2XQKU@28889|Crenarchaeota	28889|Crenarchaeota	L	AAA-like domain	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF87
PYH3_k127_6319327_10	56780.SYN_02017	4.586e-08	59.0	COG2164@1|root,COG2164@2|Bacteria,1N81P@1224|Proteobacteria,430JJ@68525|delta/epsilon subdivisions,2WVQQ@28221|Deltaproteobacteria,2MRZH@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Cyclophilin-like	-	-	-	ko:K09143	-	-	-	-	ko00000	-	-	-	Cyclophil_like
PYH3_k127_6319327_11	112098.XP_008611930.1	0.0004646	47.0	COG4901@1|root,KOG1767@2759|Eukaryota	2759|Eukaryota	J	structural constituent of ribosome	RPS25	GO:0000028,GO:0000184,GO:0000956,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005773,GO:0005774,GO:0005829,GO:0005840,GO:0005844,GO:0005911,GO:0006139,GO:0006401,GO:0006402,GO:0006412,GO:0006413,GO:0006518,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006725,GO:0006807,GO:0006810,GO:0006886,GO:0006950,GO:0006996,GO:0007154,GO:0008104,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009267,GO:0009506,GO:0009605,GO:0009892,GO:0009987,GO:0009991,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0015031,GO:0015833,GO:0015935,GO:0016020,GO:0016043,GO:0016070,GO:0016071,GO:0019222,GO:0019439,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030054,GO:0031090,GO:0031667,GO:0031668,GO:0031669,GO:0031974,GO:0031981,GO:0032991,GO:0033036,GO:0033365,GO:0033554,GO:0034198,GO:0034613,GO:0034622,GO:0034641,GO:0034645,GO:0034655,GO:0042254,GO:0042255,GO:0042274,GO:0042594,GO:0042788,GO:0042886,GO:0043043,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044267,GO:0044270,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044428,GO:0044437,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045047,GO:0045184,GO:0046483,GO:0046700,GO:0046907,GO:0048519,GO:0050789,GO:0050896,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0051716,GO:0055044,GO:0060255,GO:0065003,GO:0065007,GO:0070013,GO:0070727,GO:0070925,GO:0070972,GO:0071496,GO:0071702,GO:0071704,GO:0071705,GO:0071826,GO:0071840,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:0090304,GO:0097159,GO:0098588,GO:0098805,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1990904,GO:1990928	1.5.1.3,2.1.1.45	ko:K02975,ko:K10886,ko:K13998,ko:K20365	ko00240,ko00670,ko00790,ko01100,ko03010,ko03450,map00240,map00670,map00790,map01100,map03010,map03450	M00053,M00126,M00177,M00179,M00841	R00936,R00937,R00939,R00940,R02101,R02235,R02236	RC00109,RC00110,RC00158,RC00219,RC00332	br01610,ko00000,ko00001,ko00002,ko01000,ko03011,ko03400,ko04131	-	-	-	Ribosomal_S25
PYH3_k127_6319327_0	1220534.B655_1070	1.344e-159	522.0	COG1053@1|root,arCOG00571@2157|Archaea,2XTK0@28890|Euryarchaeota,23NV9@183925|Methanobacteria	183925|Methanobacteria	C	Fumarate reductase succinate dehydrogenase flavoprotein	sdhA	-	1.3.4.1	ko:K18209	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00620	R10660	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
PYH3_k127_6319327_2	386456.JQKN01000001_gene1892	1.978e-114	387.0	COG0479@1|root,arCOG00963@2157|Archaea,2Y85K@28890|Euryarchaeota,23PZE@183925|Methanobacteria	183925|Methanobacteria	C	2Fe-2S iron-sulfur cluster binding domain	-	-	1.3.4.1	ko:K18210	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00620	R10660	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG,Fer2_3,Fer4_8
PYH3_k127_6319327_5	415426.Hbut_0158	9.981e-67	232.0	COG1838@1|root,arCOG04406@2157|Archaea,2XQ9V@28889|Crenarchaeota	28889|Crenarchaeota	C	Fe-S type, tartrate fumarate subfamily, beta	-	-	4.2.1.2,4.2.1.32	ko:K01678,ko:K03780	ko00020,ko00620,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00630,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00339,R01082	RC00443,RC01382	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase_C
PYH3_k127_6319327_4	673860.AciM339_1146	8.031e-92	311.0	COG1951@1|root,arCOG04407@2157|Archaea,2XUQI@28890|Euryarchaeota,3F2K1@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	Fe-S type, tartrate fumarate subfamily, alpha	fumA	-	4.2.1.2	ko:K01677	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase
PYH3_k127_6319327_6	649638.Trad_1082	4.843e-25	113.0	COG1100@1|root,COG1100@2|Bacteria,1WJAD@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	PFAM ADP-ribosylation factor family	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	Arf
PYH3_k127_6319327_8	272557.APE_1495a	1.078e-11	66.0	COG3609@1|root,arCOG01009@2157|Archaea	2157|Archaea	K	transcriptional regulators containing the CopG Arc MetJ DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1
PYH3_k127_6319327_3	573064.Mefer_0206	4.32e-111	374.0	COG0206@1|root,arCOG02201@2157|Archaea,2XSV8@28890|Euryarchaeota,23QJU@183939|Methanococci	183939|Methanococci	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	-	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
PYH3_k127_6349390_5	192875.XP_004349918.1	2.005e-05	54.0	COG5491@1|root,KOG3232@2759|Eukaryota,38G3X@33154|Opisthokonta	33154|Opisthokonta	U	Belongs to the SNF7 family	CHMP1B	GO:0000070,GO:0000278,GO:0000280,GO:0000815,GO:0000819,GO:0000920,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005768,GO:0005770,GO:0006508,GO:0006511,GO:0006605,GO:0006623,GO:0006807,GO:0006810,GO:0006886,GO:0006996,GO:0006997,GO:0007032,GO:0007034,GO:0007049,GO:0007059,GO:0007080,GO:0007088,GO:0007346,GO:0008104,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009966,GO:0009968,GO:0009987,GO:0010008,GO:0010256,GO:0010564,GO:0010646,GO:0010648,GO:0010824,GO:0012505,GO:0015031,GO:0015833,GO:0016020,GO:0016032,GO:0016043,GO:0016050,GO:0016192,GO:0016197,GO:0019058,GO:0019068,GO:0019538,GO:0019904,GO:0019941,GO:0022402,GO:0022411,GO:0022607,GO:0023051,GO:0023057,GO:0030117,GO:0030163,GO:0030496,GO:0031090,GO:0031410,GO:0031982,GO:0032509,GO:0032511,GO:0032886,GO:0032984,GO:0032991,GO:0033036,GO:0033043,GO:0033365,GO:0034613,GO:0036257,GO:0036258,GO:0036452,GO:0039702,GO:0042058,GO:0042059,GO:0042802,GO:0042886,GO:0043162,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043632,GO:0043933,GO:0044085,GO:0044087,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044403,GO:0044419,GO:0044422,GO:0044424,GO:0044425,GO:0044433,GO:0044440,GO:0044444,GO:0044446,GO:0044464,GO:0045177,GO:0045184,GO:0045324,GO:0046605,GO:0046755,GO:0046907,GO:0048285,GO:0048475,GO:0048519,GO:0048523,GO:0048583,GO:0048585,GO:0050000,GO:0050789,GO:0050794,GO:0051128,GO:0051179,GO:0051234,GO:0051276,GO:0051301,GO:0051303,GO:0051310,GO:0051493,GO:0051603,GO:0051640,GO:0051641,GO:0051649,GO:0051656,GO:0051704,GO:0051726,GO:0051783,GO:0060236,GO:0065007,GO:0070507,GO:0070727,GO:0070925,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0071985,GO:0072594,GO:0072665,GO:0072666,GO:0090169,GO:0090224,GO:0097708,GO:0098588,GO:0098796,GO:0098805,GO:0098813,GO:0140014,GO:1901184,GO:1901185,GO:1901564,GO:1901565,GO:1901575,GO:1901673,GO:1902115,GO:1903047,GO:1904896,GO:1904903	-	ko:K12197,ko:K16230	ko04144,ko04217,map04144,map04217	M00412	-	-	ko00000,ko00001,ko00002,ko03000,ko04131,ko04147	-	-	-	Snf7
PYH3_k127_6349390_0	109871.XP_006677387.1	4.293e-75	268.0	KOG0739@1|root,KOG0739@2759|Eukaryota,38D1Q@33154|Opisthokonta,3NUSN@4751|Fungi	4751|Fungi	O	Belongs to the AAA ATPase family	VPS4	GO:0000166,GO:0002790,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005768,GO:0005783,GO:0006508,GO:0006511,GO:0006605,GO:0006623,GO:0006629,GO:0006807,GO:0006810,GO:0006886,GO:0006900,GO:0006914,GO:0006996,GO:0006997,GO:0006998,GO:0007032,GO:0007033,GO:0007034,GO:0008104,GO:0008144,GO:0008150,GO:0008152,GO:0008202,GO:0009056,GO:0009057,GO:0009306,GO:0009405,GO:0009987,GO:0010035,GO:0010038,GO:0010226,GO:0010256,GO:0012505,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0016050,GO:0016125,GO:0016192,GO:0016197,GO:0016236,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019941,GO:0022607,GO:0030163,GO:0030447,GO:0030448,GO:0030554,GO:0031410,GO:0031982,GO:0032507,GO:0032509,GO:0032511,GO:0032553,GO:0032555,GO:0032559,GO:0032940,GO:0033036,GO:0033365,GO:0034067,GO:0034613,GO:0035639,GO:0036094,GO:0040007,GO:0042221,GO:0042802,GO:0042803,GO:0042886,GO:0043162,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043328,GO:0043632,GO:0043933,GO:0044085,GO:0044182,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0045053,GO:0045184,GO:0045185,GO:0045324,GO:0046903,GO:0046907,GO:0046983,GO:0050896,GO:0051179,GO:0051234,GO:0051235,GO:0051259,GO:0051260,GO:0051603,GO:0051641,GO:0051649,GO:0051651,GO:0051704,GO:0051716,GO:0061024,GO:0061919,GO:0065003,GO:0065007,GO:0065008,GO:0070676,GO:0070727,GO:0070887,GO:0071241,GO:0071248,GO:0071285,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0071985,GO:0072594,GO:0072665,GO:0072666,GO:0097159,GO:0097367,GO:0097708,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901615	-	ko:K12196	ko04144,ko04217,map04144,map04217	M00412	-	-	ko00000,ko00001,ko00002,ko04131	-	-	-	AAA,MIT,Vps4_C
PYH3_k127_6349390_6	13349.G1X017	3.018e-05	54.0	KOG4068@1|root,KOG4068@2759|Eukaryota,39S7B@33154|Opisthokonta,3P2R4@4751|Fungi,3QWVJ@4890|Ascomycota	4751|Fungi	S	Vacuolar protein-sorting-associated protein	-	GO:0000429,GO:0000430,GO:0000433,GO:0000814,GO:0003674,GO:0005198,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005768,GO:0005829,GO:0006355,GO:0006357,GO:0006508,GO:0006511,GO:0006605,GO:0006623,GO:0006807,GO:0006810,GO:0006811,GO:0006820,GO:0006862,GO:0006886,GO:0007034,GO:0007154,GO:0007584,GO:0008104,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009605,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0009991,GO:0010008,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0012505,GO:0015031,GO:0015711,GO:0015748,GO:0015833,GO:0015865,GO:0015867,GO:0015868,GO:0015893,GO:0015931,GO:0016020,GO:0016192,GO:0016197,GO:0019219,GO:0019222,GO:0019538,GO:0019941,GO:0030163,GO:0031090,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031410,GO:0031667,GO:0031668,GO:0031669,GO:0031670,GO:0031982,GO:0032509,GO:0032511,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0036452,GO:0042221,GO:0042493,GO:0042802,GO:0042803,GO:0042886,GO:0043162,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043328,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044422,GO:0044424,GO:0044425,GO:0044433,GO:0044440,GO:0044444,GO:0044446,GO:0044464,GO:0045013,GO:0045014,GO:0045184,GO:0045324,GO:0045892,GO:0045934,GO:0045990,GO:0046015,GO:0046618,GO:0046907,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051179,GO:0051234,GO:0051252,GO:0051253,GO:0051503,GO:0051603,GO:0051641,GO:0051649,GO:0051716,GO:0060255,GO:0061984,GO:0061985,GO:0061986,GO:0061987,GO:0065007,GO:0070727,GO:0070887,GO:0071496,GO:0071702,GO:0071704,GO:0071705,GO:0071985,GO:0072594,GO:0072665,GO:0072666,GO:0080090,GO:0097708,GO:0098588,GO:0098796,GO:0098805,GO:1901264,GO:1901564,GO:1901565,GO:1901575,GO:1902679,GO:1903506,GO:1903507,GO:1904669,GO:2000112,GO:2000113,GO:2001141	-	ko:K12189	ko04144,map04144	M00410	-	-	ko00000,ko00001,ko00002,ko04131,ko04147	-	-	-	ESCRT-II
PYH3_k127_6349390_2	10029.XP_007631114.1	5.563e-19	96.0	KOG3341@1|root,KOG3341@2759|Eukaryota,38FCZ@33154|Opisthokonta,3B9KQ@33208|Metazoa,3CUGF@33213|Bilateria,48ATU@7711|Chordata,49758@7742|Vertebrata,3J9XM@40674|Mammalia,35EG6@314146|Euarchontoglires,4Q2HF@9989|Rodentia	33208|Metazoa	K	regulation of multivesicular body size involved in endosome transport	SNF8	GO:0000003,GO:0000578,GO:0000814,GO:0003002,GO:0003006,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0005768,GO:0005770,GO:0005829,GO:0005886,GO:0006355,GO:0006357,GO:0006403,GO:0006508,GO:0006511,GO:0006807,GO:0006810,GO:0006886,GO:0006914,GO:0006996,GO:0007032,GO:0007034,GO:0007275,GO:0007276,GO:0007281,GO:0007292,GO:0007308,GO:0007309,GO:0007314,GO:0007350,GO:0007351,GO:0007389,GO:0008022,GO:0008104,GO:0008134,GO:0008150,GO:0008152,GO:0008283,GO:0008298,GO:0008358,GO:0008593,GO:0008595,GO:0009056,GO:0009057,GO:0009790,GO:0009798,GO:0009880,GO:0009889,GO:0009893,GO:0009894,GO:0009896,GO:0009948,GO:0009952,GO:0009966,GO:0009968,GO:0009987,GO:0009994,GO:0010008,GO:0010256,GO:0010468,GO:0010556,GO:0010604,GO:0010628,GO:0010646,GO:0010648,GO:0010796,GO:0010797,GO:0010941,GO:0012505,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0016050,GO:0016192,GO:0016197,GO:0016236,GO:0016247,GO:0016482,GO:0017157,GO:0019219,GO:0019222,GO:0019538,GO:0019941,GO:0019953,GO:0021700,GO:0022412,GO:0022414,GO:0022607,GO:0023051,GO:0023057,GO:0030154,GO:0030163,GO:0031090,GO:0031323,GO:0031326,GO:0031410,GO:0031902,GO:0031974,GO:0031981,GO:0031982,GO:0032456,GO:0032501,GO:0032502,GO:0032504,GO:0032509,GO:0032511,GO:0032535,GO:0032879,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0035282,GO:0036257,GO:0036258,GO:0036452,GO:0042058,GO:0042059,GO:0042176,GO:0042802,GO:0042803,GO:0042886,GO:0042981,GO:0043067,GO:0043162,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043328,GO:0043632,GO:0043900,GO:0043903,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044422,GO:0044424,GO:0044425,GO:0044428,GO:0044433,GO:0044440,GO:0044444,GO:0044446,GO:0044464,GO:0044703,GO:0045022,GO:0045184,GO:0045324,GO:0045450,GO:0045732,GO:0045921,GO:0046907,GO:0046983,GO:0047485,GO:0048468,GO:0048469,GO:0048471,GO:0048477,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048585,GO:0048599,GO:0048609,GO:0048856,GO:0048869,GO:0050789,GO:0050792,GO:0050794,GO:0051036,GO:0051046,GO:0051047,GO:0051049,GO:0051050,GO:0051171,GO:0051173,GO:0051179,GO:0051234,GO:0051246,GO:0051247,GO:0051252,GO:0051603,GO:0051641,GO:0051649,GO:0051704,GO:0055037,GO:0060255,GO:0060627,GO:0060810,GO:0060811,GO:0061635,GO:0061919,GO:0065007,GO:0065008,GO:0065009,GO:0070013,GO:0070727,GO:0070925,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0071944,GO:0071985,GO:0072594,GO:0072665,GO:0072666,GO:0080090,GO:0090066,GO:0097708,GO:0098588,GO:0098772,GO:0098796,GO:0098805,GO:0098927,GO:1901184,GO:1901185,GO:1901564,GO:1901565,GO:1901575,GO:1903506,GO:1903530,GO:1903532,GO:1903541,GO:1903543,GO:1903772,GO:1903900,GO:2000112,GO:2001141	-	ko:K12188	ko04144,map04144	M00410	-	-	ko00000,ko00001,ko00002,ko04131,ko04147	-	-	-	EAP30
PYH3_k127_6349390_3	192875.XP_004349177.1	5.463e-08	62.0	KOG3284@1|root,KOG3284@2759|Eukaryota,38D26@33154|Opisthokonta	33154|Opisthokonta	U	protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	VPS28	GO:0000003,GO:0000813,GO:0001654,GO:0003006,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005768,GO:0005829,GO:0006508,GO:0006511,GO:0006605,GO:0006612,GO:0006623,GO:0006807,GO:0006810,GO:0006811,GO:0006820,GO:0006862,GO:0006886,GO:0006914,GO:0006996,GO:0007010,GO:0007034,GO:0007275,GO:0007276,GO:0007281,GO:0007283,GO:0007286,GO:0007291,GO:0007349,GO:0007399,GO:0007423,GO:0008104,GO:0008150,GO:0008152,GO:0008593,GO:0009056,GO:0009057,GO:0009653,GO:0009790,GO:0009792,GO:0009892,GO:0009966,GO:0009968,GO:0009987,GO:0010008,GO:0010605,GO:0010646,GO:0010648,GO:0010796,GO:0012505,GO:0015031,GO:0015711,GO:0015748,GO:0015833,GO:0015865,GO:0015867,GO:0015868,GO:0015893,GO:0015931,GO:0016020,GO:0016043,GO:0016192,GO:0016197,GO:0016236,GO:0016322,GO:0019222,GO:0019538,GO:0019941,GO:0019953,GO:0021700,GO:0022008,GO:0022411,GO:0022412,GO:0022414,GO:0023051,GO:0023057,GO:0030029,GO:0030036,GO:0030154,GO:0030163,GO:0030182,GO:0031090,GO:0031323,GO:0031324,GO:0031396,GO:0031397,GO:0031399,GO:0031400,GO:0031410,GO:0031982,GO:0032268,GO:0032269,GO:0032501,GO:0032502,GO:0032504,GO:0032509,GO:0032511,GO:0032535,GO:0032801,GO:0032984,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0036452,GO:0040008,GO:0042058,GO:0042059,GO:0042221,GO:0042493,GO:0042551,GO:0042886,GO:0043112,GO:0043162,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043328,GO:0043632,GO:0043900,GO:0043901,GO:0043903,GO:0043933,GO:0044126,GO:0044130,GO:0044144,GO:0044146,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044422,GO:0044424,GO:0044425,GO:0044433,GO:0044440,GO:0044444,GO:0044446,GO:0044464,GO:0044703,GO:0045184,GO:0045324,GO:0045926,GO:0046618,GO:0046907,GO:0048232,GO:0048468,GO:0048469,GO:0048513,GO:0048515,GO:0048519,GO:0048523,GO:0048583,GO:0048585,GO:0048609,GO:0048646,GO:0048666,GO:0048699,GO:0048731,GO:0048749,GO:0048856,GO:0048869,GO:0050789,GO:0050794,GO:0050896,GO:0051036,GO:0051171,GO:0051172,GO:0051179,GO:0051234,GO:0051246,GO:0051248,GO:0051503,GO:0051603,GO:0051641,GO:0051649,GO:0051704,GO:0060255,GO:0061919,GO:0065007,GO:0065008,GO:0070727,GO:0071695,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0071985,GO:0072594,GO:0072657,GO:0072665,GO:0072666,GO:0080090,GO:0090066,GO:0090150,GO:0097352,GO:0097708,GO:0098588,GO:0098796,GO:0098805,GO:1901184,GO:1901185,GO:1901264,GO:1901564,GO:1901565,GO:1901575,GO:1903320,GO:1903321,GO:1904669	-	ko:K12184	ko04144,map04144	M00409	-	-	ko00000,ko00001,ko00002,ko04131,ko04147	-	-	-	VPS28
PYH3_k127_6349390_7	5693.XP_814003.1	0.0003295	51.0	COG5078@1|root,KOG0421@2759|Eukaryota,3XV1D@5653|Kinetoplastida	5653|Kinetoplastida	O	Belongs to the ubiquitin-conjugating enzyme family	-	-	2.3.2.23	ko:K06688	ko04120,map04120	-	-	-	ko00000,ko00001,ko01000,ko04121	-	-	-	UQ_con
PYH3_k127_6349390_8	31234.CRE10339	0.0007567	47.0	29JZW@1|root,2RT8Q@2759|Eukaryota,39GBF@33154|Opisthokonta,3CK6J@33208|Metazoa,3E1SB@33213|Bilateria,40PD6@6231|Nematoda,1M6VX@119089|Chromadorea,415E2@6236|Rhabditida	33208|Metazoa	O	Ring finger domain	-	-	-	-	-	-	-	-	-	-	-	-	zf-RING_2
PYH3_k127_6349390_4	3067.XP_002955038.1	1.004e-05	51.0	COG5272@1|root,KOG0001@2759|Eukaryota,388PR@33090|Viridiplantae	33090|Viridiplantae	O	Telomere stability and silencing	-	-	-	-	-	-	-	-	-	-	-	-	Telomere_Sde2
PYH3_k127_6349390_1	482537.XP_008585788.1	1.696e-23	105.0	COG5078@1|root,KOG0417@2759|Eukaryota,38B6R@33154|Opisthokonta,3BBRF@33208|Metazoa,3CUBW@33213|Bilateria	33208|Metazoa	O	protein K48-linked ubiquitination	UBE2D2	-	2.3.2.23	ko:K06689	ko04013,ko04120,ko04141,ko04624,map04013,map04120,map04141,map04624	-	-	-	ko00000,ko00001,ko01000,ko04121	-	-	-	UQ_con
PYH3_k127_638352_2	313606.M23134_08247	5.31e-34	133.0	COG1171@1|root,COG1171@2|Bacteria,4NEY2@976|Bacteroidetes,47KNZ@768503|Cytophagia	976|Bacteroidetes	E	Pyridoxal-phosphate dependent enzyme	ilvA	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
PYH3_k127_638352_1	1295642.H839_17048	1.018e-61	227.0	COG2516@1|root,COG2516@2|Bacteria,1UI8Q@1239|Firmicutes,4HV1D@91061|Bacilli	91061|Bacilli	S	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
PYH3_k127_638352_4	305700.B447_03283	0.000558	50.0	COG0454@1|root,COG0456@2|Bacteria,1QUZC@1224|Proteobacteria,2WGMV@28216|Betaproteobacteria	28216|Betaproteobacteria	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_3
PYH3_k127_638352_0	1304874.JAFY01000002_gene135	6.835e-73	258.0	COG0601@1|root,COG0601@2|Bacteria,3TAG1@508458|Synergistetes	508458|Synergistetes	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
PYH3_k127_638352_3	111780.Sta7437_3389	3.049e-05	54.0	COG1413@1|root,COG1413@2|Bacteria,1G341@1117|Cyanobacteria,3VJEU@52604|Pleurocapsales	1117|Cyanobacteria	C	PFAM PBS lyase HEAT-like repeat	nblB	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
PYH3_k127_6401041_4	644281.MFS40622_0682	1.337e-05	54.0	COG0500@1|root,arCOG01774@2157|Archaea,2Y0V8@28890|Euryarchaeota,23RIT@183939|Methanococci	183939|Methanococci	Q	PFAM Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
PYH3_k127_6401041_3	529709.PYCH_01970	4.279e-22	103.0	arCOG04797@1|root,arCOG04797@2157|Archaea,2XZMY@28890|Euryarchaeota,24531@183968|Thermococci	183968|Thermococci	S	retrograde transport, endosome to Golgi	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_6401041_0	591019.Shell_1216	3.612e-122	400.0	COG1180@1|root,arCOG00946@2157|Archaea,2XPTQ@28889|Crenarchaeota	28889|Crenarchaeota	C	PFAM Radical SAM domain protein	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Radical_SAM
PYH3_k127_6401041_1	234267.Acid_0497	2.926e-62	221.0	COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,3Y2GR@57723|Acidobacteria	57723|Acidobacteria	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM,Cytochrom_C,Cytochrome_CBB3
PYH3_k127_6401041_2	234267.Acid_0496	6.351e-36	139.0	COG1999@1|root,COG1999@2|Bacteria,3Y3XH@57723|Acidobacteria	57723|Acidobacteria	S	signal sequence binding	-	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	SCO1-SenC
PYH3_k127_6438756_0	439235.Dalk_0164	1.341e-201	650.0	COG1882@1|root,COG1882@2|Bacteria,1MWBF@1224|Proteobacteria,42M5J@68525|delta/epsilon subdivisions,2WJAK@28221|Deltaproteobacteria	1224|Proteobacteria	C	formate C-acetyltransferase glycine radical	-	-	-	-	-	-	-	-	-	-	-	-	PFL-like
PYH3_k127_6438756_3	439235.Dalk_0163	1.312e-79	276.0	COG1180@1|root,COG1180@2|Bacteria,1QJHU@1224|Proteobacteria,42R2E@68525|delta/epsilon subdivisions,2WMYN@28221|Deltaproteobacteria,2MJPF@213118|Desulfobacterales	1224|Proteobacteria	C	PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
PYH3_k127_6438756_7	439235.Dalk_0162	3.273e-14	82.0	COG3576@1|root,COG3576@2|Bacteria	2|Bacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	GAF_2,Putative_PNPOx
PYH3_k127_6438756_1	479434.Sthe_1955	2.595e-112	374.0	COG3191@1|root,COG3191@2|Bacteria,2G83F@200795|Chloroflexi,27YT6@189775|Thermomicrobia	189775|Thermomicrobia	EQ	Peptidase family S58	-	-	3.4.11.19	ko:K01266	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S58
PYH3_k127_6438756_6	1089553.Tph_c04870	4.989e-35	141.0	COG0704@1|root,COG0704@2|Bacteria,1URN3@1239|Firmicutes,24FTM@186801|Clostridia,42FW2@68295|Thermoanaerobacterales	186801|Clostridia	P	Plays a role in the regulation of phosphate uptake	phoU	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
PYH3_k127_6438756_2	1050201.KB913034_gene641	2.097e-96	322.0	COG1117@1|root,COG1117@2|Bacteria,1TP1M@1239|Firmicutes,3VPAI@526524|Erysipelotrichia	526524|Erysipelotrichia	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
PYH3_k127_6438756_4	593750.Metfor_2080	1.188e-55	207.0	COG0581@1|root,arCOG00168@2157|Archaea,2Y8DS@28890|Euryarchaeota,2N9FR@224756|Methanomicrobia	224756|Methanomicrobia	P	phosphate ABC transporter, inner membrane subunit PstA	-	-	-	ko:K02037,ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
PYH3_k127_6438756_5	1499967.BAYZ01000028_gene1314	6.609e-52	195.0	COG0573@1|root,COG0573@2|Bacteria,2NPS2@2323|unclassified Bacteria	2|Bacteria	P	probably responsible for the translocation of the substrate across the membrane	-	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
PYH3_k127_6477231_1	858215.Thexy_2211	1.39e-97	336.0	COG4354@1|root,COG4354@2|Bacteria,1TR78@1239|Firmicutes,25K1B@186801|Clostridia,42ITY@68295|Thermoanaerobacterales	186801|Clostridia	G	beta-glucosidase 2, glycosyl-hydrolase family 116 N-term	-	-	3.2.1.45	ko:K17108	ko00511,ko00600,ko01100,map00511,map00600,map01100	-	R01498	RC00059,RC00451	ko00000,ko00001,ko01000	-	GH116	-	DUF608,Glyco_hydr_116N
PYH3_k127_6477231_2	268407.PWYN_19130	8.811e-59	213.0	COG1246@1|root,COG1246@2|Bacteria,1TRN6@1239|Firmicutes,4HB4C@91061|Bacilli,2777Z@186822|Paenibacillaceae	91061|Bacilli	E	YoaP-like	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,YoaP
PYH3_k127_6477231_0	304371.MCP_1274	3.44e-230	737.0	COG0474@1|root,arCOG01578@2157|Archaea,2XT4B@28890|Euryarchaeota,2N91H@224756|Methanomicrobia	224756|Methanomicrobia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	-	-	-	-	-	-	-	-	-	-	Cation_ATPase_N,E1-E2_ATPase,Hydrolase
PYH3_k127_6477231_3	944480.ATUV01000001_gene1130	3.428e-42	162.0	COG1351@1|root,COG1351@2|Bacteria,1Q73I@1224|Proteobacteria,42S3A@68525|delta/epsilon subdivisions,2X6UX@28221|Deltaproteobacteria,2M6MD@213113|Desulfurellales	28221|Deltaproteobacteria	F	Thymidylate synthase complementing protein	thyX	-	2.1.1.148	ko:K03465	ko00240,ko00670,ko01100,map00240,map00670,map01100	-	R06613	RC00022,RC00332	ko00000,ko00001,ko01000	-	-	-	Thy1
PYH3_k127_6477231_5	1047013.AQSP01000105_gene1458	2.747e-16	84.0	2ERMK@1|root,33J72@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF3795)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3795
PYH3_k127_6477231_4	511051.CSE_15430	3.955e-22	98.0	arCOG04032@1|root,33VX1@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_6486778_10	399550.Smar_1446	0.000308	49.0	COG5625@1|root,arCOG04189@2157|Archaea,2XQWI@28889|Crenarchaeota	28889|Crenarchaeota	K	HTH DNA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_6486778_8	342949.PNA2_1471	4.556e-18	85.0	COG0298@1|root,arCOG04427@2157|Archaea,2Y0AJ@28890|Euryarchaeota,244KI@183968|Thermococci	183968|Thermococci	O	HupF/HypC family	-	-	-	ko:K04653	-	-	-	-	ko00000	-	-	-	HupF_HypC
PYH3_k127_6486778_0	224325.AF_2039	2.335e-74	261.0	COG0144@1|root,arCOG00973@2157|Archaea,2XUFZ@28890|Euryarchaeota,245P3@183980|Archaeoglobi	183980|Archaeoglobi	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltr_RsmB-F,Methyltr_RsmF_N
PYH3_k127_6486778_9	1198449.ACAM_0398	5.646e-09	64.0	COG1374@1|root,arCOG00993@2157|Archaea,2XS7B@28889|Crenarchaeota	28889|Crenarchaeota	J	Uncharacterised protein family (UPF0113)	-	-	-	ko:K07565	-	-	-	-	ko00000,ko03009	-	-	-	UPF0113
PYH3_k127_6486778_6	1041930.Mtc_1419	1.043e-25	111.0	COG2058@1|root,arCOG04287@2157|Archaea,2XYQ9@28890|Euryarchaeota,2N9U8@224756|Methanomicrobia	224756|Methanomicrobia	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rpl12	-	-	ko:K02869	ko03010,map03010	M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_60s
PYH3_k127_6486778_4	634498.mru_0486	6.848e-38	154.0	COG0244@1|root,arCOG04288@2157|Archaea,2XU7C@28890|Euryarchaeota,23NKW@183925|Methanobacteria	183925|Methanobacteria	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rpl10	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
PYH3_k127_6486778_2	521011.Mpal_0163	1.712e-47	179.0	COG0081@1|root,arCOG04289@2157|Archaea,2XTJF@28890|Euryarchaeota,2N9HV@224756|Methanomicrobia	224756|Methanomicrobia	J	Binds directly to 23S rRNA. Probably involved in E site tRNA release	rpl1	-	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
PYH3_k127_6486778_3	529709.PYCH_18180	3.346e-44	166.0	COG0080@1|root,arCOG04372@2157|Archaea,2XTJN@28890|Euryarchaeota,243FN@183968|Thermococci	183968|Thermococci	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rpl11	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
PYH3_k127_6486778_5	573064.Mefer_1447	3.081e-37	146.0	COG0250@1|root,arCOG01920@2157|Archaea,2XWGQ@28890|Euryarchaeota,23QVR@183939|Methanococci	183939|Methanococci	K	Transcription elongation factor Spt5	spt5	GO:0003674,GO:0003676,GO:0003677,GO:0003723,GO:0003729,GO:0005488,GO:0006139,GO:0006351,GO:0006354,GO:0006355,GO:0006357,GO:0006366,GO:0006368,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016071,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:2000112,GO:2001141	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,Spt5-NGN
PYH3_k127_6486778_11	192952.MM_1009	0.0007936	44.0	COG2443@1|root,arCOG02204@2157|Archaea,2Y188@28890|Euryarchaeota,2NA63@224756|Methanomicrobia	224756|Methanomicrobia	U	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation	secE	-	-	ko:K07342	ko03060,ko04141,ko04145,ko05110,map03060,map04141,map04145,map05110	M00401	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.7,3.A.5.8,3.A.5.9	-	-	-
PYH3_k127_6486778_1	523850.TON_0175	7.557e-48	182.0	COG1650@1|root,arCOG01616@2157|Archaea,2XUM0@28890|Euryarchaeota,243DT@183968|Thermococci	183968|Thermococci	J	D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo	dtdA	-	3.1.1.96	ko:K09716	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_deacylase
PYH3_k127_6486778_7	1206732.BAGD01000061_gene2339	1.369e-25	107.0	COG0078@1|root,COG0078@2|Bacteria,2GJ6H@201174|Actinobacteria,4FUYG@85025|Nocardiaceae	201174|Actinobacteria	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0040007,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
PYH3_k127_6534332_0	1054217.TALC_01157	8.401e-104	347.0	COG0540@1|root,arCOG00911@2157|Archaea,2XSZ7@28890|Euryarchaeota,241J0@183967|Thermoplasmata	183967|Thermoplasmata	F	aspartate carbamoyltransferase activity	pyrB	-	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
PYH3_k127_6534332_2	529709.PYCH_07510	2.372e-46	174.0	COG1781@1|root,arCOG04229@2157|Archaea,2XWP4@28890|Euryarchaeota,2441P@183968|Thermococci	183968|Thermococci	F	Involved in allosteric regulation of aspartate carbamoyltransferase	pyrI	-	-	ko:K00610	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002	-	-	-	PyrI,PyrI_C
PYH3_k127_6534332_1	665571.STHERM_c12740	2.329e-51	199.0	COG0284@1|root,COG0461@1|root,COG0284@2|Bacteria,COG0461@2|Bacteria,2J6HE@203691|Spirochaetes	203691|Spirochaetes	F	Orotidine 5''-phosphate decarboxylase	pyrF	-	2.4.2.10,4.1.1.23	ko:K01591,ko:K13421	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00051	R00965,R01870,R08231	RC00063,RC00409,RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase,Pribosyltran
PYH3_k127_6554874_1	439481.Aboo_1385	5.522e-46	185.0	COG0433@1|root,arCOG00280@2157|Archaea,2Y7MA@28890|Euryarchaeota,3F30Q@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	AAA-like domain	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF87,HAS-barrel
PYH3_k127_6554874_3	368408.Tpen_0063	1.097e-28	121.0	arCOG00299@1|root,arCOG00299@2157|Archaea,2XQKR@28889|Crenarchaeota	28889|Crenarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_6554874_2	765177.Desmu_0009	2.653e-31	130.0	COG1936@1|root,arCOG01038@2157|Archaea,2XQII@28889|Crenarchaeota	28889|Crenarchaeota	F	Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates	-	-	2.7.4.3	ko:K18532	ko00230,ko01100,ko01110,ko01130,ko03008,map00230,map01100,map01110,map01130,map03008	M00049	R00127,R01547	RC00002	ko00000,ko00001,ko00002,ko01000,ko03009	-	-	-	AAA_18
PYH3_k127_6554874_0	1459636.NTE_02266	1.013e-96	328.0	COG0008@1|root,arCOG04302@2157|Archaea,41S5V@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
PYH3_k127_6560783_2	877455.Metbo_0700	7.858e-54	196.0	COG2048@1|root,arCOG00372@1|root,arCOG00372@2157|Archaea,arCOG00964@2157|Archaea,2XXYP@28890|Euryarchaeota,23NZ8@183925|Methanobacteria	183925|Methanobacteria	C	reductase, subunit	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03390	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_8
PYH3_k127_6560783_0	224719.Abm4_1308	1.255e-93	316.0	COG2048@1|root,arCOG00338@2157|Archaea,2XTWJ@28890|Euryarchaeota,23NJW@183925|Methanobacteria	183925|Methanobacteria	C	reductase, subunit	hdrB1	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
PYH3_k127_6560783_3	439235.Dalk_1630	2.293e-20	96.0	COG1146@1|root,COG1146@2|Bacteria,1N0QV@1224|Proteobacteria,42U2Z@68525|delta/epsilon subdivisions,2WR58@28221|Deltaproteobacteria,2MM2N@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	1.2.7.3	ko:K00176	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Fer4_7
PYH3_k127_6560783_1	706587.Desti_0013	3.162e-89	300.0	COG0674@1|root,COG0674@2|Bacteria,1NBSJ@1224|Proteobacteria,42MS1@68525|delta/epsilon subdivisions,2WJ97@28221|Deltaproteobacteria,2MRFE@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	ferredoxin oxidoreductase, alpha subunit	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
PYH3_k127_6697565_2	224325.AF_1286	1.049e-08	63.0	COG0123@1|root,arCOG00324@2157|Archaea	2157|Archaea	BQ	including yeast histone deacetylase and acetoin utilization protein	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
PYH3_k127_6697565_3	4155.Migut.F00486.1.p	2.662e-07	64.0	COG1196@1|root,KOG0250@2759|Eukaryota,37NTZ@33090|Viridiplantae,3GA7T@35493|Streptophyta,44HH5@71274|asterids	35493|Streptophyta	L	Structural maintenance of chromosomes	-	GO:0000724,GO:0000725,GO:0000819,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007049,GO:0007059,GO:0007062,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016043,GO:0022402,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0071704,GO:0071840,GO:0090304,GO:0098813,GO:1901360	-	-	-	-	-	-	-	-	-	-	AAA_23,SMC_N
PYH3_k127_6697565_1	1042377.AFPJ01000042_gene1094	1.93e-11	77.0	COG1305@1|root,COG1305@2|Bacteria,1NEY1@1224|Proteobacteria,1SF7F@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
PYH3_k127_6697565_0	1035308.AQYY01000001_gene2089	9.36e-24	111.0	COG0454@1|root,COG0456@2|Bacteria,1VHPQ@1239|Firmicutes,24P0Y@186801|Clostridia	186801|Clostridia	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
PYH3_k127_6697565_4	673860.AciM339_1318	4.864e-07	61.0	COG1599@1|root,arCOG01510@2157|Archaea,2Y73X@28890|Euryarchaeota,3F3CQ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	OB-fold nucleic acid binding domain	-	-	-	-	-	-	-	-	-	-	-	-	tRNA_anti-codon
PYH3_k127_6697565_5	394221.Mmar10_3065	1.254e-06	58.0	COG0476@1|root,COG0476@2|Bacteria,1MW7H@1224|Proteobacteria,2TRWY@28211|Alphaproteobacteria,43XCD@69657|Hyphomonadaceae	28211|Alphaproteobacteria	H	COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2	moeB	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF
PYH3_k127_6720584_0	1365176.N186_05835	1.091e-105	354.0	COG1313@1|root,arCOG00934@2157|Archaea,2XPK3@28889|Crenarchaeota	28889|Crenarchaeota	C	PFAM Radical SAM domain protein	-	-	1.97.1.4	ko:K04070	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
PYH3_k127_672709_3	930945.SiRe_1901	0.0004327	49.0	arCOG03770@1|root,arCOG03770@2157|Archaea	2157|Archaea	M	metalloendopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_672709_1	1501230.ET33_32420	1.647e-48	185.0	COG2159@1|root,COG2159@2|Bacteria,1TT5D@1239|Firmicutes,4HAHP@91061|Bacilli,26V85@186822|Paenibacillaceae	91061|Bacilli	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
PYH3_k127_672709_2	926569.ANT_07650	5.23e-42	170.0	COG0577@1|root,COG0577@2|Bacteria,2G65B@200795|Chloroflexi	200795|Chloroflexi	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
PYH3_k127_672709_0	390874.Tpet_0568	5.02e-74	256.0	COG1136@1|root,COG1136@2|Bacteria,2GCNV@200918|Thermotogae	200918|Thermotogae	P	PFAM ABC transporter	-	-	-	ko:K02003,ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
PYH3_k127_6815848_5	446470.Snas_6073	3.163e-22	100.0	COG0454@1|root,COG0456@2|Bacteria,2INMX@201174|Actinobacteria	201174|Actinobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
PYH3_k127_6815848_3	439481.Aboo_0836	3.802e-39	154.0	COG2236@1|root,arCOG00040@2157|Archaea,2XU0E@28890|Euryarchaeota,3F38W@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	Phosphoribosyl transferase domain	-	-	2.4.2.22	ko:K00769,ko:K07101	ko00230,ko01100,ko01110,map00230,map01100,map01110	-	R01229,R02142	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
PYH3_k127_6815848_2	410358.Mlab_1274	9.581e-58	216.0	arCOG12322@1|root,arCOG12322@2157|Archaea,2Y5I1@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_6815848_1	368408.Tpen_0618	5.122e-95	321.0	COG0005@1|root,arCOG01327@2157|Archaea,2XPU0@28889|Crenarchaeota	28889|Crenarchaeota	F	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates	mtnP	-	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
PYH3_k127_6815848_4	1459636.NTE_01818	4.98e-26	112.0	arCOG05900@1|root,arCOG05900@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,LexA_DNA_bind
PYH3_k127_6815848_0	1123274.KB899429_gene2872	7.667e-204	653.0	COG0013@1|root,COG0013@2|Bacteria,2J5G2@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
PYH3_k127_684109_3	521098.Aaci_1629	5.872e-07	55.0	COG1986@1|root,COG1986@2|Bacteria,1V6CG@1239|Firmicutes,4HIVY@91061|Bacilli	91061|Bacilli	F	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions	yjjX	GO:0003674,GO:0003824,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111	-	-	-	-	-	-	-	-	-	-	NTPase_I-T
PYH3_k127_684109_1	415426.Hbut_1150	1.321e-34	139.0	COG1656@1|root,arCOG04290@2157|Archaea,2XQD5@28889|Crenarchaeota	28889|Crenarchaeota	S	Mut7-C RNAse domain	-	-	-	ko:K09122	-	-	-	-	ko00000	-	-	-	Mut7-C
PYH3_k127_684109_0	1343739.PAP_02470	5.688e-113	382.0	COG1530@1|root,arCOG00321@2157|Archaea,2XU9U@28890|Euryarchaeota,242NX@183968|Thermococci	183968|Thermococci	L	Putative modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
PYH3_k127_684109_2	1343739.PAP_02465	2.241e-29	129.0	COG0312@1|root,arCOG00322@2157|Archaea,2XV41@28890|Euryarchaeota,242W4@183968|Thermococci	183968|Thermococci	S	Putative modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
PYH3_k127_6855225_0	555079.Toce_2001	1.449e-202	638.0	COG2403@1|root,COG2403@2|Bacteria,1TPZD@1239|Firmicutes,24E2D@186801|Clostridia,42HSE@68295|Thermoanaerobacterales	186801|Clostridia	S	CobW/HypB/UreG, nucleotide-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cobW
PYH3_k127_6855225_1	391623.TERMP_00873	1.151e-132	446.0	COG0018@1|root,arCOG00487@2157|Archaea,2XTWP@28890|Euryarchaeota,24339@183968|Thermococci	183968|Thermococci	J	Belongs to the class-I aminoacyl-tRNA synthetase family	argS	GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
PYH3_k127_6886625_2	751944.HALDL1_13245	0.0001166	52.0	COG0477@1|root,arCOG00132@2157|Archaea,2XVCP@28890|Euryarchaeota,23UPN@183963|Halobacteria	183963|Halobacteria	G	COG0477 Permeases of the major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
PYH3_k127_6886625_1	1121406.JAEX01000012_gene643	5.162e-12	72.0	COG3467@1|root,COG3467@2|Bacteria,1N4RH@1224|Proteobacteria,42TKQ@68525|delta/epsilon subdivisions,2WQ06@28221|Deltaproteobacteria,2MBAF@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM Pyridoxamine 5'-phosphate oxidase-related	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Pyridox_ox_2
PYH3_k127_6886625_0	1380390.JIAT01000010_gene4475	1.108e-43	169.0	COG3214@1|root,COG3214@2|Bacteria,2HPYW@201174|Actinobacteria,4CRE6@84995|Rubrobacteria	84995|Rubrobacteria	S	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_42
PYH3_k127_690241_1	264732.Moth_0405	5.353e-26	121.0	COG4986@1|root,COG4986@2|Bacteria,1TRRR@1239|Firmicutes,248X4@186801|Clostridia,42HSS@68295|Thermoanaerobacterales	186801|Clostridia	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
PYH3_k127_690241_3	419947.MRA_0499A	0.0006472	48.0	28WQB@1|root,2ZIQ0@2|Bacteria,2INA2@201174|Actinobacteria,239ZE@1762|Mycobacteriaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_690241_0	543526.Htur_1225	1.945e-27	127.0	COG0451@1|root,arCOG01369@2157|Archaea,2XTTP@28890|Euryarchaeota,23STH@183963|Halobacteria	183963|Halobacteria	M	NAD-dependent epimerase dehydratase	-	-	5.1.3.2,5.1.3.25	ko:K01784,ko:K17947	ko00052,ko00520,ko00523,ko01100,ko01130,map00052,map00520,map00523,map01100,map01130	M00361,M00362,M00632	R00291,R02984,R10279	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
PYH3_k127_690241_2	410358.Mlab_1026	7.812e-09	67.0	COG2041@1|root,arCOG00266@2157|Archaea	2157|Archaea	P	COG2041 Sulfite oxidase and related enzymes	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Oxidored_molyb,Peripla_BP_2
PYH3_k127_6928610_3	1365176.N186_01015	4.384e-06	53.0	arCOG00022@1|root,arCOG00022@2157|Archaea,2XQTH@28889|Crenarchaeota	28889|Crenarchaeota	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
PYH3_k127_6928610_2	399550.Smar_0592	1.601e-08	61.0	arCOG00022@1|root,arCOG00022@2157|Archaea	2157|Archaea	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_6928610_0	339860.Msp_0290	1.135e-102	346.0	COG0399@1|root,arCOG00118@2157|Archaea,2XTRQ@28890|Euryarchaeota,23NU5@183925|Methanobacteria	183925|Methanobacteria	E	Belongs to the DegT DnrJ EryC1 family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
PYH3_k127_6928610_1	1459636.NTE_02312	2.823e-41	162.0	COG1817@1|root,arCOG01395@2157|Archaea,41S8D@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Protein of unknown function (DUF354)	-	-	-	ko:K09726	-	-	-	-	ko00000	-	-	-	DUF354
PYH3_k127_696430_0	693661.Arcve_1116	5.056e-88	304.0	COG1148@1|root,COG1908@1|root,arCOG02235@2157|Archaea,arCOG02475@2157|Archaea,2XT3X@28890|Euryarchaeota,245U1@183980|Archaeoglobi	28890|Euryarchaeota	C	Heterodisulfide reductase subunit A and related polyferredoxins	hdrA-2	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388,ko:K16886	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_17,Fer4_4,Fer4_7,Fer4_9,FlpD,Pyr_redox_2
PYH3_k127_696430_1	1094980.Mpsy_2950	2.915e-68	250.0	COG1145@1|root,arCOG02180@2157|Archaea,2XV84@28890|Euryarchaeota,2N9ND@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	fwdF-1	-	-	ko:K00205	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060,R11743	RC00197,RC00323	ko00000,ko00001,ko00002	-	-	-	Fer4,Fer4_4,Fer4_7
PYH3_k127_696430_3	1104324.P186_2499	1.697e-24	111.0	COG0705@1|root,arCOG01768@2157|Archaea,2XQ3A@28889|Crenarchaeota	28889|Crenarchaeota	E	PFAM Rhomboid family protein	-	-	-	ko:K07059	-	-	-	-	ko00000	-	-	-	Rhomboid
PYH3_k127_696430_4	324602.Caur_0203	1.12e-14	85.0	COG1920@1|root,COG1920@2|Bacteria,2G76R@200795|Chloroflexi,377X9@32061|Chloroflexia	32061|Chloroflexia	H	Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor	cofC	GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0043814,GO:0044237,GO:0044249,GO:0051186,GO:0051188,GO:0070568	2.7.7.68	ko:K14941	ko00680,ko01120,map00680,map01120	M00378	R09397	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CofC
PYH3_k127_696430_2	368408.Tpen_1831	5.778e-57	216.0	COG2211@1|root,arCOG00146@2157|Archaea,2XSCD@28889|Crenarchaeota	28889|Crenarchaeota	G	PFAM major facilitator superfamily MFS_1	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
PYH3_k127_696433_1	572478.Vdis_1890	3.388e-32	128.0	COG1389@1|root,arCOG01165@2157|Archaea,2XPVY@28889|Crenarchaeota	28889|Crenarchaeota	L	Relaxes both positive and negative superturns and exhibits a strong decatenase activity	top6B	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	5.99.1.3	ko:K03167	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	FbpA,HATPase_c,HATPase_c_3,Topo-VIb_trans
PYH3_k127_696433_3	453591.Igni_0153	2.596e-13	78.0	COG0681@1|root,arCOG01739@2157|Archaea,2XQV6@28889|Crenarchaeota	28889|Crenarchaeota	U	TIGRFAM peptidase S26B, signal peptidase	-	-	3.4.21.89	ko:K13280	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
PYH3_k127_696433_0	999630.TUZN_1845	2.422e-128	421.0	COG1812@1|root,arCOG01678@2157|Archaea,2XPSB@28889|Crenarchaeota	28889|Crenarchaeota	H	Catalyzes the formation of S-adenosylmethionine from methionine and ATP	mat	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	AdoMet_Synthase
PYH3_k127_696433_2	420247.Msm_1583	5.855e-21	98.0	COG1202@1|root,arCOG00554@2157|Archaea,2XUCK@28890|Euryarchaeota,23NWH@183925|Methanobacteria	183925|Methanobacteria	L	PFAM DNA RNA helicase, DEAD DEAH box type, N-terminal	-	-	-	ko:K03725	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,Helicase_C
PYH3_k127_6966497_0	694429.Pyrfu_0974	5.442e-69	248.0	COG0468@1|root,arCOG00415@2157|Archaea,2XPN0@28889|Crenarchaeota	28889|Crenarchaeota	L	Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules	radA	GO:0000150,GO:0000217,GO:0000400,GO:0000724,GO:0000725,GO:0000730,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003697,GO:0003824,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006312,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022607,GO:0033554,GO:0034622,GO:0034641,GO:0042148,GO:0042623,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0045003,GO:0046483,GO:0050896,GO:0051716,GO:0065003,GO:0065004,GO:0071704,GO:0071824,GO:0071840,GO:0090304,GO:0090735,GO:0097159,GO:0140097,GO:1901360,GO:1901363	-	ko:K04483	-	-	-	-	ko00000,ko03400	-	-	-	HHH_5,Rad51
PYH3_k127_6973362_3	1392838.AWNM01000017_gene3570	1.145e-37	145.0	COG4319@1|root,COG4319@2|Bacteria,1NHKV@1224|Proteobacteria	1224|Proteobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
PYH3_k127_6973362_2	1214065.BAGV01000052_gene1846	4.03e-57	209.0	COG1584@1|root,COG1584@2|Bacteria,1N3HP@1224|Proteobacteria,1RMRK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	GPR1 FUN34 yaaH family protein	yaaH	GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006835,GO:0006846,GO:0006855,GO:0008028,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015077,GO:0015078,GO:0015123,GO:0015238,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015355,GO:0015360,GO:0015672,GO:0015711,GO:0015718,GO:0015740,GO:0015744,GO:0015849,GO:0015893,GO:0016020,GO:0022804,GO:0022857,GO:0022890,GO:0034220,GO:0035433,GO:0042221,GO:0042493,GO:0042891,GO:0042895,GO:0043893,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071422,GO:0071702,GO:0071944,GO:0098655,GO:0098656,GO:0098660,GO:0098662,GO:1902600,GO:1903825,GO:1905039	-	ko:K07034	-	-	-	-	ko00000	-	-	-	Grp1_Fun34_YaaH
PYH3_k127_6973362_1	1122947.FR7_1086	1.484e-80	281.0	COG1902@1|root,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,4H39X@909932|Negativicutes	909932|Negativicutes	C	NADH flavin oxidoreductase NADH oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN
PYH3_k127_6973362_0	309800.C498_01035	4.979e-113	376.0	COG0520@1|root,arCOG00065@2157|Archaea,2XYKY@28890|Euryarchaeota,23ZYZ@183963|Halobacteria	183963|Halobacteria	E	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
PYH3_k127_698027_2	1128421.JAGA01000002_gene565	4.544e-45	168.0	COG0388@1|root,COG0388@2|Bacteria,2NPKU@2323|unclassified Bacteria	2|Bacteria	S	Carbon-nitrogen hydrolase	mtnU	-	3.5.1.3	ko:K11206,ko:K13566	ko00250,map00250	-	R00269,R00348	RC00010	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase
PYH3_k127_698027_3	693661.Arcve_1337	1.248e-07	61.0	COG1392@1|root,arCOG02640@2157|Archaea,2XYDJ@28890|Euryarchaeota	28890|Euryarchaeota	P	Phosphate transport regulator	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
PYH3_k127_698027_1	604354.TSIB_0767	1.598e-103	347.0	COG0309@1|root,arCOG00636@2157|Archaea,2XTAH@28890|Euryarchaeota,245CI@183968|Thermococci	183968|Thermococci	O	AIR synthase related protein, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AIRS,AIRS_C
PYH3_k127_698027_0	391623.TERMP_00459	4.46e-109	364.0	COG0452@1|root,arCOG01704@2157|Archaea,2XTZK@28890|Euryarchaeota,242ZD@183968|Thermococci	183968|Thermococci	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	-	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
PYH3_k127_7051484_0	573064.Mefer_0150	1.178e-49	180.0	COG1222@1|root,arCOG01306@2157|Archaea,2XTB6@28890|Euryarchaeota,23Q87@183939|Methanococci	183939|Methanococci	O	ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C- terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates	pan	GO:0000502,GO:0003674,GO:0003824,GO:0003924,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0022623,GO:0022624,GO:0030163,GO:0032991,GO:0043170,GO:0043273,GO:0043335,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369	-	ko:K03420	ko03050,map03050	M00343	-	-	ko00000,ko00001,ko00002,ko03051	-	-	-	AAA
PYH3_k127_7051484_2	572546.Arcpr_0261	2.063e-38	149.0	COG1370@1|root,arCOG00991@2157|Archaea,2XYFT@28890|Euryarchaeota,2471G@183980|Archaeoglobi	183980|Archaeoglobi	O	PUA domain containing protein	-	-	-	ko:K07398	-	-	-	-	ko00000	-	-	-	PUA,TGT_C2
PYH3_k127_7051484_3	485914.Hmuk_3183	7.578e-17	87.0	COG1308@1|root,arCOG04061@2157|Archaea,2XXYV@28890|Euryarchaeota,23W5Q@183963|Halobacteria	183963|Halobacteria	K	Contacts the emerging nascent chain on the ribosome	nac	-	-	ko:K03626	-	-	-	-	ko00000	-	-	-	NAC,UBA_4
PYH3_k127_7051484_1	1183377.Py04_0335	1.284e-48	184.0	COG1394@1|root,arCOG04101@2157|Archaea,2XTQ5@28890|Euryarchaeota,242NT@183968|Thermococci	183968|Thermococci	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpD	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
PYH3_k127_7051484_4	694429.Pyrfu_0405	1.803e-14	78.0	COG0358@1|root,arCOG04281@2157|Archaea,2XPXM@28889|Crenarchaeota	28889|Crenarchaeota	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	Toprim_4
PYH3_k127_7056014_4	1227349.C170_29198	3.998e-11	76.0	COG0454@1|root,COG0456@2|Bacteria,1TQQA@1239|Firmicutes,4HBXN@91061|Bacilli,26RQ4@186822|Paenibacillaceae	91061|Bacilli	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
PYH3_k127_7056014_0	374847.Kcr_0867	1.089e-101	346.0	COG0351@1|root,arCOG00020@2157|Archaea	2157|Archaea	H	Phosphomethylpyrimidine kinase	thiD	-	2.5.1.3,2.7.1.49,2.7.4.7	ko:K00941,ko:K21219,ko:K21220	ko00730,ko01100,map00730,map01100	M00127	R03223,R03471,R04509,R10712	RC00002,RC00017,RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	Phos_pyr_kin,ThiP_synth
PYH3_k127_7056014_2	374847.Kcr_0869	5.557e-30	126.0	arCOG04316@1|root,arCOG04316@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_7056014_1	374847.Kcr_0868	1.765e-32	138.0	COG4732@1|root,arCOG04317@2157|Archaea	2157|Archaea	S	Thiamine-precursor transporter protein (ThiW)	-	-	-	-	-	-	-	-	-	-	-	-	ThiW
PYH3_k127_7056014_3	1101190.ARWB01000001_gene3687	5.925e-16	88.0	COG1457@1|root,COG1457@2|Bacteria,1PYF6@1224|Proteobacteria,2VFVZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	F	Permease for cytosine/purines, uracil, thiamine, allantoin	-	-	-	-	-	-	-	-	-	-	-	-	Transp_cyt_pur
PYH3_k127_7064261_6	643648.Slip_1706	1.147e-07	57.0	COG0599@1|root,COG0599@2|Bacteria,1URBN@1239|Firmicutes,2596G@186801|Clostridia,42KS5@68298|Syntrophomonadaceae	186801|Clostridia	S	Carboxymuconolactone decarboxylase family	-	-	-	-	-	-	-	-	-	-	-	-	CMD
PYH3_k127_7064261_1	521011.Mpal_0671	7.604e-51	189.0	arCOG02576@1|root,arCOG02576@2157|Archaea,2XZNM@28890|Euryarchaeota,2N9WU@224756|Methanomicrobia	224756|Methanomicrobia	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
PYH3_k127_7064261_5	906968.Trebr_1157	8.339e-27	119.0	COG3871@1|root,COG3871@2|Bacteria,2J9F1@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Pyridoxamine 5'-phosphate oxidase-like, FMN-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Pyrid_ox_like
PYH3_k127_7064261_3	1469948.JPNB01000002_gene2784	1.129e-31	130.0	COG1846@1|root,COG1846@2|Bacteria,1V8KT@1239|Firmicutes,24B99@186801|Clostridia,36KPX@31979|Clostridiaceae	186801|Clostridia	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR
PYH3_k127_7064261_2	1499967.BAYZ01000033_gene1105	1.785e-32	133.0	COG0655@1|root,COG0655@2|Bacteria	2|Bacteria	S	NAD(P)H dehydrogenase (quinone) activity	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
PYH3_k127_7064261_4	406327.Mevan_1562	6.905e-31	127.0	COG1510@1|root,arCOG02795@2157|Archaea,2Y3Q8@28890|Euryarchaeota,23RMF@183939|Methanococci	183939|Methanococci	K	Belongs to the GbsR family	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_7064261_0	391037.Sare_1461	1.358e-67	241.0	2EXXE@1|root,33R6H@2|Bacteria,2H1T6@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_7097398_1	313612.L8106_24795	1.817e-77	267.0	COG0215@1|root,COG0215@2|Bacteria,1G02K@1117|Cyanobacteria,1H70N@1150|Oscillatoriales	1117|Cyanobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e
PYH3_k127_7097398_4	555088.DealDRAFT_2117	1.534e-38	156.0	COG0428@1|root,COG0428@2|Bacteria,1TP7J@1239|Firmicutes,247Q2@186801|Clostridia,42K4J@68298|Syntrophomonadaceae	186801|Clostridia	P	PFAM zinc iron permease	-	-	-	ko:K07238	-	-	-	-	ko00000,ko02000	2.A.5.5	-	-	Zip
PYH3_k127_7097398_2	1395587.P364_0121295	1.209e-76	273.0	COG1055@1|root,COG1055@2|Bacteria,1TPNN@1239|Firmicutes,4H9WV@91061|Bacilli,26R11@186822|Paenibacillaceae	91061|Bacilli	P	Involved in arsenical resistance. Thought to form the channel of an arsenite pump	-	-	-	ko:K03893	-	-	-	-	ko00000,ko02000	2.A.45.1,3.A.4.1	-	-	ArsB
PYH3_k127_7097398_3	565033.GACE_1736	1.692e-42	177.0	COG1269@1|root,arCOG04138@2157|Archaea,2XTQP@28890|Euryarchaeota,245R0@183980|Archaeoglobi	183980|Archaeoglobi	C	Belongs to the V-ATPase 116 kDa subunit family	-	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
PYH3_k127_7097398_5	445972.ANACOL_00851	8.089e-11	74.0	COG0636@1|root,COG0636@2|Bacteria,1V786@1239|Firmicutes,24HBF@186801|Clostridia,3WJD9@541000|Ruminococcaceae	186801|Clostridia	C	ATP synthase subunit C	ntpK	-	-	ko:K02124	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_C
PYH3_k127_7097398_6	70448.A0A090M7I0	1.399e-09	70.0	COG0636@1|root,KOG0232@2759|Eukaryota,37J2Q@33090|Viridiplantae,34HKM@3041|Chlorophyta	3041|Chlorophyta	P	Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells	-	-	-	ko:K02155	ko00190,ko01100,ko04142,ko04145,ko04721,ko04966,ko05110,ko05120,ko05152,ko05323,map00190,map01100,map04142,map04145,map04721,map04966,map05110,map05120,map05152,map05323	M00160	-	-	ko00000,ko00001,ko00002	3.A.2.2	-	-	ATP-synt_C
PYH3_k127_7097398_7	1301098.PKB_2012	2.815e-08	59.0	COG3255@1|root,COG3255@2|Bacteria,1N206@1224|Proteobacteria,1S8RI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Sterol carrier protein	-	-	-	-	-	-	-	-	-	-	-	-	SCP2
PYH3_k127_7097398_0	760011.Spico_1044	4.204e-82	289.0	COG0006@1|root,COG0673@1|root,COG0006@2|Bacteria,COG0673@2|Bacteria,2J6T7@203691|Spirochaetes	203691|Spirochaetes	E	Oxidoreductase family, C-terminal alpha beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
PYH3_k127_7097398_8	226186.BT_2949	4.814e-05	56.0	COG1331@1|root,COG1331@2|Bacteria,4P0B5@976|Bacteroidetes,2FXEG@200643|Bacteroidia,4AUFQ@815|Bacteroidaceae	976|Bacteroidetes	O	Glycosyl hydrolase family 76	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_76
PYH3_k127_7156406_2	1121472.AQWN01000007_gene1144	4.966e-66	232.0	COG1228@1|root,COG1228@2|Bacteria,1TP2J@1239|Firmicutes,24AGR@186801|Clostridia,260J1@186807|Peptococcaceae	186801|Clostridia	Q	PFAM Amidohydrolase family	hutI	-	3.5.2.7	ko:K01468	ko00340,ko01100,map00340,map01100	M00045	R02288	RC00683	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
PYH3_k127_7156406_1	763034.HMPREF9446_01897	7.702e-95	320.0	COG3643@1|root,COG3643@2|Bacteria,4NFE3@976|Bacteroidetes,2FMWT@200643|Bacteroidia,4AMG0@815|Bacteroidaceae	976|Bacteroidetes	E	Glutamate formiminotransferase	ftcD	-	2.1.2.5,4.3.1.4	ko:K00603,ko:K13990	ko00340,ko00670,ko01100,map00340,map00670,map01100	-	R02287,R02302,R03189	RC00165,RC00221,RC00223,RC00688,RC00870	ko00000,ko00001,ko01000,ko03036,ko04147	-	-	-	FTCD,FTCD_C,FTCD_N
PYH3_k127_7156406_0	1295642.H839_05644	4.15e-240	754.0	COG2987@1|root,COG2987@2|Bacteria,1TPZ9@1239|Firmicutes,4H9NH@91061|Bacilli,1WE9Z@129337|Geobacillus	91061|Bacilli	E	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate	hutU	-	4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000	-	-	-	Urocanase,Urocanase_C,Urocanase_N
PYH3_k127_7156406_3	552811.Dehly_0134	4.997e-35	146.0	COG1526@1|root,COG1526@2|Bacteria,2G74E@200795|Chloroflexi	200795|Chloroflexi	C	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH	fdhD	-	-	ko:K02379	-	-	-	-	ko00000	-	-	-	FdhD-NarQ
PYH3_k127_7156406_4	1041930.Mtc_1754	5.661e-24	111.0	COG1718@1|root,arCOG01180@2157|Archaea,2XU2H@28890|Euryarchaeota,2N9ET@224756|Methanomicrobia	224756|Methanomicrobia	T	serine threonine protein kinase	-	-	2.7.11.1	ko:K07178	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko01001,ko03009	-	-	-	RIO1
PYH3_k127_7229729_3	1304874.JAFY01000007_gene2426	4.34e-37	150.0	COG0215@1|root,COG0215@2|Bacteria,3TAAB@508458|Synergistetes	508458|Synergistetes	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e
PYH3_k127_7229729_1	1042877.GQS_07550	9.722e-76	274.0	COG0651@1|root,arCOG01537@2157|Archaea,2XU88@28890|Euryarchaeota,242ND@183968|Thermococci	183968|Thermococci	C	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus	-	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M,Proton_antipo_N
PYH3_k127_7229729_0	1131266.ARWQ01000015_gene758	2.113e-86	304.0	COG0651@1|root,arCOG01537@2157|Archaea,41SAV@651137|Thaumarchaeota	651137|Thaumarchaeota	C	plastoquinone (complex I)	-	-	1.6.5.3	ko:K00342,ko:K12137,ko:K12141	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
PYH3_k127_7229729_2	1459636.NTE_02550	2.852e-53	201.0	COG1009@1|root,arCOG01539@2157|Archaea,41SC4@651137|Thaumarchaeota	651137|Thaumarchaeota	C	TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain L	-	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
PYH3_k127_7242852_6	1112204.GPOL_c15200	2.785e-18	95.0	2ERKW@1|root,33J6D@2|Bacteria,2I7F1@201174|Actinobacteria,4GGVG@85026|Gordoniaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_7242852_0	456442.Mboo_1369	4.263e-141	462.0	COG1456@1|root,arCOG01979@2157|Archaea,2XUSG@28890|Euryarchaeota,2N9BD@224756|Methanomicrobia	224756|Methanomicrobia	C	Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing	cdhE	-	2.1.1.245	ko:K00197	ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200	M00357,M00377,M00422	R09096,R10219,R10243	RC00004,RC00113,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhD,FeS
PYH3_k127_7242852_1	1183377.Py04_1782	7.756e-92	318.0	COG1602@1|root,arCOG04269@2157|Archaea,2XTEQ@28890|Euryarchaeota,242NB@183968|Thermococci	183968|Thermococci	S	Archaeal Nre, N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Nre_C,Nre_N
PYH3_k127_7242852_4	646529.Desaci_0681	6.774e-25	112.0	COG2020@1|root,COG2020@2|Bacteria,1VKIT@1239|Firmicutes	1239|Firmicutes	O	PFAM Isoprenylcysteine carboxyl methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	ICMT,PEMT
PYH3_k127_7242852_2	309799.DICTH_0579	7.054e-44	167.0	COG1853@1|root,COG1853@2|Bacteria	2|Bacteria	S	FMN binding	flr	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
PYH3_k127_7242852_7	273063.STK_24490	1.126e-15	86.0	COG0813@1|root,arCOG01325@2157|Archaea	2157|Archaea	F	Phosphorylase superfamily	-	-	2.4.2.1	ko:K03784	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244	RC00033,RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
PYH3_k127_7242852_3	269797.Mbar_A1271	3.153e-42	163.0	COG2220@1|root,arCOG00497@2157|Archaea,2XUPM@28890|Euryarchaeota,2NATF@224756|Methanomicrobia	224756|Methanomicrobia	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
PYH3_k127_7242852_5	324602.Caur_3164	2.092e-18	90.0	COG2267@1|root,COG2267@2|Bacteria,2G6W2@200795|Chloroflexi	200795|Chloroflexi	I	PFAM alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
PYH3_k127_7349996_1	335541.Swol_1605	4.458e-87	295.0	COG0031@1|root,COG0031@2|Bacteria,1UV8X@1239|Firmicutes,258FH@186801|Clostridia,42KFI@68298|Syntrophomonadaceae	186801|Clostridia	H	Pyridoxal-phosphate dependent enzyme	-	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
PYH3_k127_7349996_2	192952.MM_2961	1.139e-53	199.0	COG5012@1|root,arCOG02030@2157|Archaea,2Y8I2@28890|Euryarchaeota,2NAGA@224756|Methanomicrobia	224756|Methanomicrobia	S	Acts as a methyl group carrier between MtbB and MtbA	-	-	-	ko:K16179	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09999	RC00035,RC00556,RC02986	ko00000,ko00001,ko00002	-	-	-	B12-binding,B12-binding_2
PYH3_k127_7349996_0	1047013.AQSP01000134_gene1338	3.105e-126	419.0	COG5598@1|root,COG5598@2|Bacteria,2NQTC@2323|unclassified Bacteria	2|Bacteria	H	Trimethylamine methyltransferase (MTTB)	-	-	2.1.1.250	ko:K14083	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09124,R10016	RC00035,RC00732,RC01144,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	MTTB
PYH3_k127_7349996_4	10141.ENSCPOP00000005219	1.217e-09	69.0	COG1100@1|root,KOG0070@2759|Eukaryota,38D1T@33154|Opisthokonta,3BN8W@33208|Metazoa,3CWE4@33213|Bilateria,486JF@7711|Chordata,495RS@7742|Vertebrata,3J1TU@40674|Mammalia,35GDU@314146|Euarchontoglires,4PUP8@9989|Rodentia	33208|Metazoa	U	ADP-ribosylation factor-like protein 11	ARL11	GO:0002244,GO:0002376,GO:0002520,GO:0007275,GO:0008150,GO:0009987,GO:0030097,GO:0030154,GO:0032501,GO:0032502,GO:0048513,GO:0048534,GO:0048731,GO:0048856,GO:0048869	-	ko:K07959	-	-	-	-	ko00000,ko04031	-	-	-	Arf
PYH3_k127_7349996_3	429009.Adeg_1792	2.808e-42	160.0	COG1387@1|root,COG1796@1|root,COG1387@2|Bacteria,COG1796@2|Bacteria,1TQ33@1239|Firmicutes,249TZ@186801|Clostridia,42FCI@68295|Thermoanaerobacterales	186801|Clostridia	L	DNA polymerase	polX	-	-	ko:K02347	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_palm,DNA_pol_B_thumb,HHH_5,HHH_8,PHP
PYH3_k127_7363360_2	456442.Mboo_2377	3.535e-16	91.0	COG0747@1|root,arCOG01534@2157|Archaea	2157|Archaea	E	ABC-type dipeptide transport system periplasmic component	appA	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
PYH3_k127_7363360_0	368408.Tpen_0817	8.946e-148	483.0	COG0008@1|root,arCOG00402@2157|Archaea,2XPVB@28889|Crenarchaeota	28889|Crenarchaeota	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro)	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,ProRS-C_1,tRNA-synt_2b
PYH3_k127_7363360_1	1131266.ARWQ01000008_gene303	3.012e-64	230.0	COG0726@1|root,arCOG02877@2157|Archaea	2157|Archaea	G	4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process	-	-	3.5.1.104	ko:K22278	-	-	-	-	ko00000,ko01000	-	-	-	Polysacc_deac_1
PYH3_k127_7365748_4	357808.RoseRS_3668	1.002e-17	84.0	COG0350@1|root,COG0350@2|Bacteria	2|Bacteria	L	methylated-DNA-[protein]-cysteine S-methyltransferase activity	ogt	-	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1,Methyltransf_1N
PYH3_k127_7365748_0	1123288.SOV_6c02550	1.063e-83	287.0	COG2267@1|root,COG2267@2|Bacteria,1UJA6@1239|Firmicutes	1239|Firmicutes	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
PYH3_k127_7365748_2	304371.MCP_2978	7.157e-45	169.0	COG1036@1|root,arCOG01705@2157|Archaea,2XXGS@28890|Euryarchaeota,2N9QW@224756|Methanomicrobia	224756|Methanomicrobia	C	Flavoprotein	-	-	-	-	-	-	-	-	-	-	-	-	Flavoprotein
PYH3_k127_7365748_1	1094980.Mpsy_2028	9.11e-81	273.0	COG0655@1|root,arCOG02573@2157|Archaea,2XVV1@28890|Euryarchaeota,2N9GH@224756|Methanomicrobia	224756|Methanomicrobia	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
PYH3_k127_7365748_3	318424.EU78_13220	1.579e-31	138.0	COG3214@1|root,COG3214@2|Bacteria,2GK0T@201174|Actinobacteria,2360Z@1762|Mycobacteriaceae	201174|Actinobacteria	S	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_42
PYH3_k127_7365748_6	1343739.PAP_00875	0.0001373	49.0	arCOG03769@1|root,arCOG03769@2157|Archaea,2Y3V9@28890|Euryarchaeota,245JM@183968|Thermococci	183968|Thermococci	M	glucosylceramidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_7365748_5	1293047.CBMA010000053_gene3344	2.754e-06	57.0	2DZAE@1|root,2N5T3@2157|Archaea,2Y3PF@28890|Euryarchaeota,23ZME@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_7403785_4	1333523.L593_09650	5.073e-21	101.0	COG1234@1|root,arCOG00501@2157|Archaea,2XTJ9@28890|Euryarchaeota,23SER@183963|Halobacteria	183963|Halobacteria	J	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA	rnz	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
PYH3_k127_7403785_1	694429.Pyrfu_0958	1.476e-126	420.0	COG0252@1|root,arCOG01924@2157|Archaea,2XPTP@28889|Crenarchaeota	28889|Crenarchaeota	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate	gatD	-	6.3.5.7	ko:K09482	ko00970,ko01100,map00970,map01100	-	R03905	RC00010	ko00000,ko00001,ko01000	-	-	-	Asparaginase
PYH3_k127_7403785_0	694429.Pyrfu_0957	9.04e-196	634.0	COG2511@1|root,arCOG01719@2157|Archaea,2XPPH@28889|Crenarchaeota	28889|Crenarchaeota	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate	gatE	GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.3.5.7	ko:K03330	ko00970,ko01100,map00970,map01100	-	R03905	RC00010	ko00000,ko00001,ko01000	-	-	-	GAD,GatB_N,GatB_Yqey
PYH3_k127_7403785_2	1198449.ACAM_1029	7.561e-125	416.0	COG0423@1|root,arCOG00405@2157|Archaea,2XPSF@28889|Crenarchaeota	28889|Crenarchaeota	J	PFAM tRNA synthetase, class II (G, H, P and S)	glyS	GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0016874,GO:0016875,GO:0046983,GO:0140098,GO:0140101	6.1.1.14	ko:K01880	ko00970,map00970	M00359,M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	HGTP_anticodon,tRNA-synt_2b
PYH3_k127_7403785_3	591158.SSMG_07727	2.788e-22	100.0	COG3118@1|root,COG3118@2|Bacteria,2IQ9T@201174|Actinobacteria	201174|Actinobacteria	O	belongs to the thioredoxin family	trxA	GO:0003674,GO:0003824,GO:0004791,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009055,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0015037,GO:0015038,GO:0016020,GO:0016209,GO:0016491,GO:0016651,GO:0016657,GO:0016667,GO:0016668,GO:0016671,GO:0019725,GO:0022900,GO:0030312,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0047134,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0071944,GO:0080007,GO:0097237,GO:0098754,GO:0098869,GO:1990748	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
PYH3_k127_7403785_5	386456.JQKN01000007_gene3202	3.543e-17	90.0	COG2229@1|root,arCOG00362@2157|Archaea	386456.JQKN01000007_gene3202|-	K	TIGRFAM Small GTP-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_745168_1	1089548.KI783301_gene2845	1.736e-28	124.0	COG1647@1|root,COG1647@2|Bacteria,1TQ7X@1239|Firmicutes,4HBE6@91061|Bacilli,3WFJS@539002|Bacillales incertae sedis	91061|Bacilli	S	BAAT / Acyl-CoA thioester hydrolase C terminal	est	-	3.1.1.1	ko:K03928	-	-	-	-	ko00000,ko01000	-	-	-	Hydrolase_4
PYH3_k127_745168_0	1121324.CLIT_2c02360	2.15e-66	235.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11,Methyltransf_25
PYH3_k127_7458170_0	926569.ANT_14230	3.341e-284	892.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2G5W2@200795|Chloroflexi	200795|Chloroflexi	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
PYH3_k127_7458170_1	765177.Desmu_0550	1.961e-53	205.0	COG0747@1|root,arCOG01534@2157|Archaea,2XPZY@28889|Crenarchaeota	28889|Crenarchaeota	E	PFAM extracellular solute-binding protein, family 5	dppA	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
PYH3_k127_7463859_1	926550.CLDAP_15660	1.135e-64	226.0	COG0318@1|root,COG0318@2|Bacteria,2G5Q8@200795|Chloroflexi	200795|Chloroflexi	IQ	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
PYH3_k127_7463859_0	935948.KE386494_gene333	1.892e-128	421.0	COG4952@1|root,COG4952@2|Bacteria,1UD8H@1239|Firmicutes,24HDU@186801|Clostridia,42FRC@68295|Thermoanaerobacterales	186801|Clostridia	G	Xylose isomerase-like TIM barrel	-	-	5.3.1.5	ko:K01805	ko00040,ko00051,ko01100,map00040,map00051,map01100	-	R00878,R01432	RC00376,RC00516	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
PYH3_k127_7463859_2	398767.Glov_1809	2.11e-13	76.0	COG2905@1|root,COG2905@2|Bacteria,1MW8U@1224|Proteobacteria,42NAX@68525|delta/epsilon subdivisions,2WJF5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	CBS domain containing protein	-	-	-	ko:K07182	-	-	-	-	ko00000	-	-	-	CBS,DUF294,DUF294_C,cNMP_binding
PYH3_k127_7463859_3	1423734.JCM14202_376	4.891e-06	55.0	COG0315@1|root,COG0315@2|Bacteria,1V3J4@1239|Firmicutes,4HH39@91061|Bacilli,3F65H@33958|Lactobacillaceae	91061|Bacilli	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
PYH3_k127_7508321_2	1382306.JNIM01000001_gene651	1.351e-05	53.0	COG1649@1|root,COG1649@2|Bacteria	2|Bacteria	F	PFAM Uncharacterised BCR, COG1649	-	-	3.2.1.11,3.2.1.18,3.2.1.35,4.2.2.23	ko:K01186,ko:K01197,ko:K05988,ko:K11931,ko:K18197	ko00500,ko00511,ko00531,ko00600,ko01100,ko02026,ko04142,map00500,map00511,map00531,map00600,map01100,map02026,map04142	M00076,M00077	R04018,R07824,R07825,R10905,R11309	RC00028,RC00077	ko00000,ko00001,ko00002,ko00536,ko00537,ko01000,ko02042	-	GH33,GH66,PL11	-	DUF1349,GHL10,Glyco_hydro_20b,Laminin_G_3,NAGidase,fn3
PYH3_k127_7508321_0	118173.KB235910_gene4790	2.033e-77	274.0	COG4552@1|root,COG4552@2|Bacteria	2|Bacteria	S	transferase activity, transferring acyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_9,SCP2_2
PYH3_k127_7508321_1	621372.ACIH01000055_gene1157	6.518e-58	220.0	COG2211@1|root,COG2211@2|Bacteria,1TRA5@1239|Firmicutes,4HJPK@91061|Bacilli,275UP@186822|Paenibacillaceae	91061|Bacilli	G	MFS/sugar transport protein	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
PYH3_k127_7535362_4	530564.Psta_1561	0.0003408	51.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080,HEAT_2,HEAT_PBS,Nfu_N
PYH3_k127_7535362_3	1089553.Tph_c15740	3.992e-13	72.0	COG4231@1|root,COG4231@2|Bacteria,1UN0W@1239|Firmicutes	1239|Firmicutes	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
PYH3_k127_7535362_1	744872.Spica_2171	6.433e-42	157.0	COG0251@1|root,COG0251@2|Bacteria,2J8EX@203691|Spirochaetes	203691|Spirochaetes	J	endoribonuclease L-PSP	-	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
PYH3_k127_7535362_0	1121422.AUMW01000011_gene93	5.436e-86	301.0	COG2070@1|root,COG2070@2|Bacteria,1VTQJ@1239|Firmicutes,24ZN0@186801|Clostridia,26495@186807|Peptococcaceae	186801|Clostridia	S	FMN-dependent dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	NMO
PYH3_k127_7535362_2	688269.Theth_0659	2.585e-31	131.0	COG1670@1|root,COG1670@2|Bacteria,2GCZ2@200918|Thermotogae	200918|Thermotogae	J	PFAM GCN5-related N-acetyltransferase	-	-	2.3.1.57	ko:K00657	ko00330,ko01100,ko04216,map00330,map01100,map04216	M00135	R01154	RC00004,RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_3
PYH3_k127_7535905_1	565033.GACE_1903	6.187e-42	163.0	COG0247@1|root,arCOG00333@2157|Archaea,2Y85G@28890|Euryarchaeota,245SC@183980|Archaeoglobi	183980|Archaeoglobi	C	4Fe-4S dicluster domain	-	-	1.8.98.1	ko:K08264	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	-	R04540	RC00011	ko00000,ko00001,ko01000	-	-	-	CCG,Fer4_17
PYH3_k127_7535905_2	439235.Dalk_2834	4.971e-32	143.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,43B2Q@68525|delta/epsilon subdivisions,2WK38@28221|Deltaproteobacteria,2MJTZ@213118|Desulfobacterales	28221|Deltaproteobacteria	C	FAD linked oxidases, C-terminal domain	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
PYH3_k127_7535905_0	926569.ANT_31250	2.75e-99	336.0	COG0474@1|root,COG0474@2|Bacteria,2G5ZS@200795|Chloroflexi	200795|Chloroflexi	P	TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
PYH3_k127_7538092_0	415426.Hbut_0960	1.184e-126	423.0	COG1389@1|root,arCOG01165@2157|Archaea,2XPVY@28889|Crenarchaeota	28889|Crenarchaeota	L	Relaxes both positive and negative superturns and exhibits a strong decatenase activity	top6B	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	5.99.1.3	ko:K03167	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	FbpA,HATPase_c,HATPase_c_3,Topo-VIb_trans
PYH3_k127_7538092_1	1131266.ARWQ01000005_gene788	1.424e-114	383.0	COG1697@1|root,arCOG04143@2157|Archaea,41SQF@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Relaxes both positive and negative superturns and exhibits a strong decatenase activity	top6A	-	5.99.1.3	ko:K03166	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	TP6A_N
PYH3_k127_7538092_2	1123075.AUDP01000051_gene101	2.177e-96	332.0	COG3875@1|root,COG3875@2|Bacteria,1TQ1C@1239|Firmicutes,247PH@186801|Clostridia,3WHY8@541000|Ruminococcaceae	186801|Clostridia	S	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
PYH3_k127_7542092_3	1184251.TCELL_0292	1.482e-05	52.0	arCOG00022@1|root,arCOG00022@2157|Archaea,2XQTH@28889|Crenarchaeota	28889|Crenarchaeota	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
PYH3_k127_7542092_2	247490.KSU1_C0660	3.773e-61	221.0	COG1533@1|root,COG1533@2|Bacteria,2IX0U@203682|Planctomycetes	203682|Planctomycetes	L	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
PYH3_k127_7542092_4	1054217.TALC_01558	0.0005536	46.0	arCOG15091@1|root,arCOG15091@2157|Archaea,2Y4G3@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_7542092_0	644281.MFS40622_0211	2.246e-109	371.0	COG0374@1|root,arCOG01549@2157|Archaea,2XTHE@28890|Euryarchaeota,23Q5H@183939|Methanococci	183939|Methanococci	C	Belongs to the NiFe NiFeSe hydrogenase large subunit family	-	-	1.8.98.5	ko:K14126	ko00680,map00680	-	R00019,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
PYH3_k127_7542092_1	644281.MFS40622_0212	5.319e-67	237.0	COG1941@1|root,arCOG02472@2157|Archaea,2XV6A@28890|Euryarchaeota,23QG6@183939|Methanococci	183939|Methanococci	C	PFAM NADH ubiquinone oxidoreductase 20 kDa subunit	-	-	1.8.98.5	ko:K14128	ko00680,map00680	-	R00019,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	Oxidored_q6
PYH3_k127_7544020_1	688269.Theth_1981	3.354e-28	115.0	COG0444@1|root,COG0444@2|Bacteria,2GCDR@200918|Thermotogae	200918|Thermotogae	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
PYH3_k127_7544020_0	1183377.Py04_0348	6.491e-104	348.0	COG4608@1|root,arCOG00184@2157|Archaea,2Y5BH@28890|Euryarchaeota,243F9@183968|Thermococci	183968|Thermococci	E	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
PYH3_k127_7544020_3	368407.Memar_2450	2.981e-07	59.0	COG0640@1|root,arCOG00394@2157|Archaea	2157|Archaea	K	transcriptional regulators	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	HTH_24,HTH_27,HTH_5
PYH3_k127_7544020_2	1229909.NSED_08490	1.182e-08	67.0	COG1404@1|root,arCOG00704@2157|Archaea,41SEM@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
PYH3_k127_7556763_3	1384049.CD29_12670	8.572e-07	61.0	COG0842@1|root,COG0842@2|Bacteria,1V0J8@1239|Firmicutes,4HEBH@91061|Bacilli	91061|Bacilli	V	ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
PYH3_k127_7556763_0	368408.Tpen_1400	2.759e-77	271.0	COG1131@1|root,arCOG00194@2157|Archaea,2XPS7@28889|Crenarchaeota	28889|Crenarchaeota	V	PFAM ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
PYH3_k127_7556763_2	56780.SYN_02034	9.511e-14	81.0	COG3743@1|root,COG3743@2|Bacteria,1RA3K@1224|Proteobacteria	1224|Proteobacteria	S	Domain of unknown function (DUF4332)	MA20_15755	-	-	-	-	-	-	-	-	-	-	-	DUF4332
PYH3_k127_7556763_1	1230342.CTM_26790	4.381e-40	153.0	28NEG@1|root,320U5@2|Bacteria,1V2CD@1239|Firmicutes,24PY8@186801|Clostridia,36JV2@31979|Clostridiaceae	186801|Clostridia	S	Staygreen protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3888,Staygreen
PYH3_k127_7562034_3	1033806.HTIA_2018	5.839e-17	87.0	COG0852@1|root,arCOG01551@2157|Archaea	2157|Archaea	C	NADH dehydrogenase (Ubiquinone), 30 kDa subunit	echD	-	1.6.5.3	ko:K00332,ko:K14089	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa,Complex1_49kDa,NiFeSe_Hases
PYH3_k127_7562034_1	693661.Arcve_1338	1.835e-77	284.0	COG1927@1|root,arCOG04382@2157|Archaea,2XUX3@28890|Euryarchaeota,24626@183980|Archaeoglobi	183980|Archaeoglobi	C	Catalyzes the oxidation of methylene-H(4)MPT to methenyl-H(4)MPT( )	mtd	-	1.5.98.1	ko:K00319	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R04456	RC00202	ko00000,ko00001,ko00002,ko01000	-	-	-	MTD
PYH3_k127_7562034_2	572546.Arcpr_1589	2.864e-59	229.0	COG1035@1|root,arCOG02650@2157|Archaea,2XVXF@28890|Euryarchaeota,2462X@183980|Archaeoglobi	28890|Euryarchaeota	C	PFAM Coenzyme F420 hydrogenase dehydrogenase beta subunit	-	-	1.1.98.4,1.12.98.1	ko:K00441,ko:K22174	ko00680,ko01100,ko01120,map00680,map01100,map01120	-	R03025	RC02628	ko00000,ko00001,ko01000	-	-	-	Fer4_21,FrhB_FdhB_C,FrhB_FdhB_N
PYH3_k127_7562034_4	273075.Ta0195	2.29e-10	68.0	COG1764@1|root,arCOG03688@2157|Archaea,2Y5W6@28890|Euryarchaeota	28890|Euryarchaeota	Q	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
PYH3_k127_7562034_0	335543.Sfum_4014	8.56e-106	354.0	COG0409@1|root,COG0409@2|Bacteria,1MU1F@1224|Proteobacteria,42M6R@68525|delta/epsilon subdivisions,2WJDQ@28221|Deltaproteobacteria,2MR11@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	TIGRFAM hydrogenase expression formation protein HypD	hypD	-	-	ko:K04654	-	-	-	-	ko00000	-	-	iAF987.Gmet_0117	HypD
PYH3_k127_7631751_0	368408.Tpen_0304	9.102e-200	632.0	COG0464@1|root,arCOG01308@2157|Archaea,2XPPI@28889|Crenarchaeota	28889|Crenarchaeota	O	Cell division protein 48 (CDC48), domain 2	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N,Vps4_C
PYH3_k127_7631751_5	985053.VMUT_1670	1.139e-51	190.0	COG2101@1|root,arCOG01764@2157|Archaea,2XQ5U@28889|Crenarchaeota	28889|Crenarchaeota	K	General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation	tbp	-	-	ko:K03120	ko03022,ko05016,ko05165,ko05166,ko05168,ko05169,ko05203,map03022,map05016,map05165,map05166,map05168,map05169,map05203	-	-	-	ko00000,ko00001,ko03000,ko03021	-	-	-	TBP
PYH3_k127_7631751_6	935948.KE386495_gene1983	1.569e-46	177.0	COG0584@1|root,COG0584@2|Bacteria,1V3W4@1239|Firmicutes,24AVJ@186801|Clostridia,42FXF@68295|Thermoanaerobacterales	186801|Clostridia	C	glycerophosphoryl diester phosphodiesterase	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
PYH3_k127_7631751_2	1158318.ATXC01000001_gene549	7.776e-87	296.0	COG0489@1|root,COG0489@2|Bacteria,2G3W5@200783|Aquificae	200783|Aquificae	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	mrp	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	ParA
PYH3_k127_7631751_7	338966.Ppro_3522	2.283e-21	98.0	COG1143@1|root,COG1143@2|Bacteria,1RK71@1224|Proteobacteria,42Y1X@68525|delta/epsilon subdivisions,2WQB3@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	ko:K14091	-	-	-	-	ko00000	-	-	-	ETF_QO,Fer4,Fer4_7
PYH3_k127_7631751_4	338966.Ppro_3523	1.45e-54	205.0	COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,42MMX@68525|delta/epsilon subdivisions,2WIX8@28221|Deltaproteobacteria	68525|delta/epsilon subdivisions	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	-	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
PYH3_k127_7631751_1	338966.Ppro_3524	8.307e-123	405.0	COG3261@1|root,COG3261@2|Bacteria,1QUBF@1224|Proteobacteria,43DST@68525|delta/epsilon subdivisions,2WJ4E@28221|Deltaproteobacteria,43TGG@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	PFAM NADH-ubiquinone oxidoreductase, chain 49kDa	-	-	1.6.5.3	ko:K00333,ko:K14090	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa,NiFeSe_Hases
PYH3_k127_7631751_3	429009.Adeg_0177	4.8e-61	219.0	COG1067@1|root,COG1674@1|root,COG1067@2|Bacteria,COG1674@2|Bacteria,1TQT5@1239|Firmicutes,248NE@186801|Clostridia,42FSR@68295|Thermoanaerobacterales	186801|Clostridia	O	Endopeptidase La	-	-	3.4.21.53	ko:K04076	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AAA_32,Lon_C
PYH3_k127_7638074_1	1303518.CCALI_01306	0.0001837	55.0	COG3209@1|root,COG3209@2|Bacteria	2|Bacteria	M	self proteolysis	-	-	-	-	-	-	-	-	-	-	-	-	Gln_amidase,HYR,RHS_repeat
PYH3_k127_7652079_8	411470.RUMGNA_01093	2.987e-09	63.0	COG0573@1|root,COG0573@2|Bacteria,1TSPP@1239|Firmicutes,249KQ@186801|Clostridia,3XZ6A@572511|Blautia	186801|Clostridia	P	probably responsible for the translocation of the substrate across the membrane	pstC	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
PYH3_k127_7652079_6	340.xcc-b100_2734	1.389e-20	104.0	COG0226@1|root,COG0226@2|Bacteria,1MUAZ@1224|Proteobacteria,1RN5Q@1236|Gammaproteobacteria,1X3FS@135614|Xanthomonadales	135614|Xanthomonadales	P	Part of the ABC transporter complex PstSACB involved in phosphate import	pstS	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
PYH3_k127_7652079_3	1229909.NSED_08685	2.16e-57	212.0	COG0704@1|root,arCOG00318@2157|Archaea,41SC5@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Phosphate uptake regulator	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin,PhoU
PYH3_k127_7652079_1	477974.Daud_0442	2.622e-80	278.0	COG0863@1|root,COG0863@2|Bacteria,1VIZR@1239|Firmicutes,25MPX@186801|Clostridia,266C8@186807|Peptococcaceae	186801|Clostridia	H	DNA methylase	-	-	2.1.1.113	ko:K00590	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
PYH3_k127_7652079_5	36914.XP_001526737.1	2.778e-34	138.0	KOG0084@1|root,KOG0084@2759|Eukaryota,38DXZ@33154|Opisthokonta,3NUNU@4751|Fungi,3QSH5@4890|Ascomycota,3RT74@4891|Saccharomycetes,479RW@766764|Debaryomycetaceae	4751|Fungi	U	GTP-binding Protein	ypt1	GO:0000045,GO:0000139,GO:0000149,GO:0000407,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005783,GO:0005789,GO:0005794,GO:0005795,GO:0005801,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0006810,GO:0006886,GO:0006888,GO:0006890,GO:0006900,GO:0006906,GO:0006914,GO:0006996,GO:0007033,GO:0007154,GO:0007165,GO:0007264,GO:0008104,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009966,GO:0009987,GO:0010646,GO:0012505,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0016050,GO:0016070,GO:0016192,GO:0016197,GO:0016236,GO:0016462,GO:0016482,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0019220,GO:0019222,GO:0019439,GO:0022406,GO:0022411,GO:0022607,GO:0023051,GO:0023052,GO:0031090,GO:0031323,GO:0031410,GO:0031982,GO:0031984,GO:0032258,GO:0032456,GO:0032984,GO:0033036,GO:0033365,GO:0034497,GO:0034498,GO:0034613,GO:0034622,GO:0034641,GO:0034655,GO:0035493,GO:0035494,GO:0035556,GO:0042147,GO:0042175,GO:0042325,GO:0042886,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043549,GO:0043624,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044422,GO:0044424,GO:0044425,GO:0044431,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0045184,GO:0046483,GO:0046700,GO:0046907,GO:0048193,GO:0048194,GO:0048211,GO:0048278,GO:0048284,GO:0048583,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051174,GO:0051179,GO:0051234,GO:0051338,GO:0051640,GO:0051641,GO:0051649,GO:0051716,GO:0061024,GO:0061025,GO:0061709,GO:0061912,GO:0061919,GO:0065003,GO:0065007,GO:0065009,GO:0070727,GO:0070925,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0072665,GO:0080134,GO:0080135,GO:0090114,GO:0090174,GO:0090304,GO:0097708,GO:0098588,GO:0098791,GO:0098827,GO:0140056,GO:1900101,GO:1901360,GO:1901361,GO:1901575,GO:1903008,GO:1905037,GO:1905897,GO:1990261	-	ko:K07874	ko05134,map05134	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	Ras
PYH3_k127_7652079_2	667014.Thein_0953	8.584e-65	230.0	COG0177@1|root,COG0177@2|Bacteria,2GH3R@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
PYH3_k127_7652079_7	1031288.AXAA01000039_gene78	1.693e-13	80.0	COG0671@1|root,COG0671@2|Bacteria,1V2ZH@1239|Firmicutes,24HRY@186801|Clostridia,36JBF@31979|Clostridiaceae	186801|Clostridia	I	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	PAP2_3
PYH3_k127_7652079_4	351160.RCIX578	2.823e-42	162.0	COG2042@1|root,arCOG04733@2157|Archaea,2XVBD@28890|Euryarchaeota,2N9PH@224756|Methanomicrobia	224756|Methanomicrobia	J	pre-rRNA processing protein involved in ribosome biogenesis	-	-	-	ko:K09140	-	-	-	-	ko00000,ko03009	-	-	-	RLI,Ribo_biogen_C
PYH3_k127_7652079_0	415426.Hbut_0933	2.343e-117	395.0	COG0063@1|root,arCOG00018@2157|Archaea,2XPXN@28889|Crenarchaeota	28889|Crenarchaeota	G	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
PYH3_k127_7652079_10	693661.Arcve_2037	0.0004119	48.0	COG1522@1|root,arCOG01117@2157|Archaea,2XZY2@28890|Euryarchaeota	28890|Euryarchaeota	K	transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
PYH3_k127_7652079_9	591019.Shell_0246	0.0001091	49.0	COG0483@1|root,arCOG01349@2157|Archaea,2XQXJ@28889|Crenarchaeota	28889|Crenarchaeota	G	PFAM Inositol monophosphatase	-	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
PYH3_k127_7667871_2	415426.Hbut_0019	2.659e-16	85.0	COG0189@1|root,arCOG01589@2157|Archaea,2XQGE@28889|Crenarchaeota	28889|Crenarchaeota	H	RimK domain protein ATP-grasp	-	-	-	ko:K05844	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	RimK
PYH3_k127_7667871_1	525909.Afer_0037	4.749e-83	288.0	COG1260@1|root,COG1260@2|Bacteria,2GKHB@201174|Actinobacteria,4CNE8@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Myo-inositol-1-phosphate synthase	ino1	-	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth
PYH3_k127_7667871_0	994573.T472_0206750	7.809e-173	561.0	COG0474@1|root,COG0474@2|Bacteria,1TPF5@1239|Firmicutes,247JN@186801|Clostridia,36DDM@31979|Clostridiaceae	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
PYH3_k127_767879_7	243232.MJ_0460	2.071e-37	146.0	COG0091@1|root,arCOG04098@2157|Archaea,2XWGN@28890|Euryarchaeota,23QU0@183939|Methanococci	183939|Methanococci	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rpl22	-	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
PYH3_k127_767879_0	868131.MSWAN_1465	2.049e-58	215.0	COG0092@1|root,arCOG04097@2157|Archaea,2XTHR@28890|Euryarchaeota,23NMY@183925|Methanobacteria	183925|Methanobacteria	J	Binds the lower part of the 30S subunit head	rps3	-	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
PYH3_k127_767879_14	415426.Hbut_1307	3.769e-09	61.0	COG0255@1|root,arCOG00785@2157|Archaea,2XRDJ@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the universal ribosomal protein uL29 family	rpl29	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
PYH3_k127_767879_15	1220534.B655_1503	6.329e-09	63.0	COG1588@1|root,arCOG00784@2157|Archaea,2Y0EN@28890|Euryarchaeota,23PQP@183925|Methanobacteria	183925|Methanobacteria	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp1	-	3.1.26.5	ko:K03538	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03016,ko03029	-	-	-	UPF0086
PYH3_k127_767879_9	263820.PTO0649	2.158e-32	129.0	COG0186@1|root,arCOG04096@2157|Archaea,2XYPE@28890|Euryarchaeota,241UC@183967|Thermoplasmata	183967|Thermoplasmata	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rps17	-	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
PYH3_k127_767879_6	415426.Hbut_1310	8.123e-46	169.0	COG0093@1|root,arCOG04095@2157|Archaea,2XQPU@28889|Crenarchaeota	28889|Crenarchaeota	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rpl14	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0097159,GO:1901363,GO:1990904	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
PYH3_k127_767879_12	1184251.TCELL_0337	1.421e-27	115.0	COG0198@1|root,arCOG04094@2157|Archaea,2XQQB@28889|Crenarchaeota	28889|Crenarchaeota	J	Located at the polypeptide exit tunnel on the outside of the subunit	rpl24	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,Ribosomal_L26
PYH3_k127_767879_1	633148.Tagg_0859	2.255e-58	212.0	COG1471@1|root,arCOG04093@2157|Archaea,2XPPZ@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eS4 family	rps4e	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02987	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	RS4NT,Ribosomal_S4e,S4
PYH3_k127_767879_2	666510.ASAC_0225	3.13e-53	196.0	COG0094@1|root,arCOG04092@2157|Archaea,2XQDJ@28889|Crenarchaeota	28889|Crenarchaeota	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rpl5	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
PYH3_k127_767879_13	368408.Tpen_0241	1.889e-12	71.0	COG0199@1|root,arCOG00782@2157|Archaea,2XR7G@28889|Crenarchaeota	28889|Crenarchaeota	J	Binds 16S rRNA, required for the assembly of 30S particles	rps14	GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008270,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043167,GO:0043169,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:1990904	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
PYH3_k127_767879_4	1183377.Py04_1691	6.233e-50	180.0	COG0096@1|root,arCOG04091@2157|Archaea,2XWMU@28890|Euryarchaeota,2440K@183968|Thermococci	183968|Thermococci	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rps8	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
PYH3_k127_767879_5	415426.Hbut_1316	1.144e-48	180.0	COG0097@1|root,arCOG04090@2157|Archaea,2XQ9A@28889|Crenarchaeota	28889|Crenarchaeota	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rpl6	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
PYH3_k127_767879_11	410359.Pcal_0175	3.313e-29	121.0	COG1717@1|root,arCOG00781@2157|Archaea,2XQI2@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eL32 family	rpl32e	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02912	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L32e
PYH3_k127_767879_8	195522.BD01_2167	8.088e-35	138.0	COG2147@1|root,arCOG04089@2157|Archaea,2XWU1@28890|Euryarchaeota,243Y0@183968|Thermococci	183968|Thermococci	J	Binds to the 23S rRNA	rpl19e	-	-	ko:K02885	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19e
PYH3_k127_767879_3	368408.Tpen_0237	6.125e-52	190.0	COG0256@1|root,arCOG04088@2157|Archaea,2XPNF@28889|Crenarchaeota	28889|Crenarchaeota	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rpl18	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18_c,Ribosomal_L5e
PYH3_k127_767879_10	1163730.FFONT_0500	8.739e-31	124.0	COG0098@1|root,arCOG04087@2157|Archaea,2XPK9@28889|Crenarchaeota	28889|Crenarchaeota	J	With S4 and S12 plays an important role in translational accuracy	rps5	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
PYH3_k127_7688540_3	877455.Metbo_2371	1.017e-37	143.0	COG0361@1|root,arCOG01179@2157|Archaea,2XXX0@28890|Euryarchaeota,23P26@183925|Methanobacteria	183925|Methanobacteria	J	Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits	eif1a	-	-	ko:K03236	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	eIF-1a
PYH3_k127_7688540_2	415426.Hbut_1592	2.966e-40	158.0	COG1756@1|root,arCOG04122@2157|Archaea,2XQJ6@28889|Crenarchaeota	28889|Crenarchaeota	J	Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA	nep1	GO:0000154,GO:0000462,GO:0001510,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0019843,GO:0022613,GO:0030490,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070037,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140098,GO:0140102,GO:1901360,GO:1901363	2.1.1.260	ko:K14568	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko03009	-	-	-	EMG1
PYH3_k127_7688540_0	351160.LRC287	1.404e-66	237.0	COG1718@1|root,arCOG01180@2157|Archaea,2XU2H@28890|Euryarchaeota,2N9ET@224756|Methanomicrobia	224756|Methanomicrobia	T	serine threonine protein kinase	-	-	2.7.11.1	ko:K07178	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko01001,ko03009	-	-	-	RIO1
PYH3_k127_7688540_1	419665.Maeo_0593	1.062e-50	186.0	COG1094@1|root,arCOG04150@2157|Archaea,2XUHX@28890|Euryarchaeota,23QSQ@183939|Methanococci	183939|Methanococci	J	SMART KH domain protein	-	-	-	ko:K06961	-	-	-	-	ko00000,ko03009	-	-	-	KH_1
PYH3_k127_7688540_4	439481.Aboo_1479	1.859e-08	66.0	arCOG13565@1|root,arCOG13565@2157|Archaea,2Y66R@28890|Euryarchaeota,3F331@33867|unclassified Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_7719901_1	323259.Mhun_0931	3.407e-44	165.0	COG4739@1|root,arCOG04483@2157|Archaea,2XYZT@28890|Euryarchaeota,2N9WC@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterized protein containing a ferredoxin domain (DUF2148)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2148,FeS
PYH3_k127_7719901_0	1184251.TCELL_0790	1.115e-75	265.0	COG0462@1|root,arCOG00067@2157|Archaea,2XRX8@28889|Crenarchaeota	28889|Crenarchaeota	F	Belongs to the ribose-phosphate pyrophosphokinase family	-	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran,Pribosyltran_N
PYH3_k127_7719901_2	1122217.KB899575_gene1949	1.415e-29	123.0	COG0378@1|root,COG0378@2|Bacteria,1TS00@1239|Firmicutes,4H2ZQ@909932|Negativicutes	909932|Negativicutes	KO	Hydrogenase accessory protein HypB	hypB	-	-	ko:K04652	-	-	-	-	ko00000,ko03110	-	-	-	cobW
PYH3_k127_773731_2	1227499.C493_06777	1.88e-07	61.0	arCOG01792@1|root,arCOG01792@2157|Archaea,2XWRG@28890|Euryarchaeota,23VI0@183963|Halobacteria	183963|Halobacteria	Q	Methylase involved in ubiquinone menaquinone biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
PYH3_k127_773731_3	272568.GDI0677	0.0007322	46.0	COG0389@1|root,COG0389@2|Bacteria,1MU5X@1224|Proteobacteria,2TQVR@28211|Alphaproteobacteria,2JR90@204441|Rhodospirillales	204441|Rhodospirillales	L	Nucleotidyltransferase DNA polymerase involved in DNA repair	-	-	-	ko:K14161	-	-	-	-	ko00000,ko03400	-	-	-	IMS
PYH3_k127_773731_0	1365176.N186_05390	1.956e-40	162.0	COG1938@1|root,arCOG00347@2157|Archaea,2XQ9W@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM PAC2 family	-	-	-	ko:K06869	-	-	-	-	ko00000	-	-	-	PAC2
PYH3_k127_773731_1	1221522.B723_15010	6.891e-09	64.0	COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,1SWNR@1236|Gammaproteobacteria,1YQ7Z@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
PYH3_k127_7771313_1	1365176.N186_04385	1.147e-55	202.0	COG0142@1|root,arCOG01726@2157|Archaea,2XPZM@28889|Crenarchaeota	28889|Crenarchaeota	H	Belongs to the FPP GGPP synthase family	fgs	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13787	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
PYH3_k127_7771313_2	673860.AciM339_0624	6.587e-42	166.0	COG0170@1|root,arCOG01880@2157|Archaea,2Y70G@28890|Euryarchaeota,3F32Z@33867|unclassified Euryarchaeota	28890|Euryarchaeota	I	PFAM phosphatidate cytidylyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_7771313_0	439481.Aboo_0423	3.224e-62	223.0	COG1608@1|root,arCOG00860@2157|Archaea,2XSUI@28890|Euryarchaeota,3F2Y8@33867|unclassified Euryarchaeota	28890|Euryarchaeota	I	Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids	argB1	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006629,GO:0006720,GO:0006721,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016114,GO:0016740,GO:0016772,GO:0016776,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0102043,GO:1901576	2.7.4.26	ko:K06981	ko00900,ko01110,ko01130,map00900,map01110,map01130	-	R10093	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
PYH3_k127_7771313_3	340177.Cag_0295	1.05e-05	53.0	COG2522@1|root,COG2522@2|Bacteria	2|Bacteria	O	sequence-specific DNA binding	-	-	-	ko:K07108,ko:K16247	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3
PYH3_k127_7820211_0	330779.Saci_0693	1.712e-279	880.0	COG0085@1|root,arCOG01762@2157|Archaea,2XPRW@28889|Crenarchaeota	28889|Crenarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K13798	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_4,RNA_pol_Rpb2_5,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
PYH3_k127_7820211_1	224719.Abm4_0986	1.102e-29	128.0	COG0680@1|root,arCOG04429@2157|Archaea,2XXAF@28890|Euryarchaeota,23P79@183925|Methanobacteria	183925|Methanobacteria	C	hydrogenase maturation protease HycI	hycI	-	3.4.23.51	ko:K08315	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	HycI
PYH3_k127_7820211_2	386456.JQKN01000001_gene1826	9.287e-21	100.0	COG1676@1|root,arCOG01701@2157|Archaea,2XTKB@28890|Euryarchaeota,23P3J@183925|Methanobacteria	183925|Methanobacteria	J	Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp	endA	-	4.6.1.16	ko:K01170	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_int_endo,tRNA_int_endo_N
PYH3_k127_7842241_0	69014.TK1833	7.143e-81	292.0	COG2433@1|root,arCOG04219@2157|Archaea,2XT3D@28890|Euryarchaeota,242ZI@183968|Thermococci	183968|Thermococci	S	Protein of unknown function (DUF460)	-	-	-	ko:K09150	-	-	-	-	ko00000	-	-	-	DUF460
PYH3_k127_7842241_2	386456.JQKN01000002_gene2402	2.101e-16	83.0	COG1958@1|root,arCOG00998@2157|Archaea,2XZTF@28890|Euryarchaeota,23P7B@183925|Methanobacteria	183925|Methanobacteria	K	Belongs to the snRNP Sm proteins family	-	-	-	ko:K04796	-	-	-	-	ko00000	-	-	-	LSM
PYH3_k127_7842241_3	439481.Aboo_0952	2.85e-07	60.0	arCOG05517@1|root,arCOG05517@2157|Archaea,2Y72T@28890|Euryarchaeota,3F3AH@33867|unclassified Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_7842241_4	1121946.AUAX01000003_gene1723	4.05e-05	53.0	COG0500@1|root,COG2226@2|Bacteria,2GKFZ@201174|Actinobacteria,4DAGF@85008|Micromonosporales	201174|Actinobacteria	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)	menG	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
PYH3_k127_7842241_1	415426.Hbut_1101	1.171e-51	192.0	COG1637@1|root,arCOG01304@2157|Archaea,2XQ7Z@28889|Crenarchaeota	28889|Crenarchaeota	L	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures	nucS	-	-	ko:K07503	-	-	-	-	ko00000,ko01000	-	-	-	NucS
PYH3_k127_7860184_0	644281.MFS40622_0209	6.122e-126	413.0	COG1148@1|root,arCOG02235@2157|Archaea,2XT3X@28890|Euryarchaeota,23QA9@183939|Methanococci	183939|Methanococci	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Pyr_redox_2
PYH3_k127_7860184_3	6087.XP_002163996.1	3.811e-31	129.0	KOG0080@1|root,KOG0080@2759|Eukaryota,38EZ7@33154|Opisthokonta,3BB89@33208|Metazoa	33208|Metazoa	U	lipid droplet organization	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005794,GO:0006996,GO:0008150,GO:0009987,GO:0012505,GO:0016043,GO:0034389,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0071840	-	ko:K07910	-	-	-	-	ko00000,ko04031,ko04131	-	-	-	Ras
PYH3_k127_7860184_1	1296990.H845_1337	7.807e-78	281.0	COG0160@1|root,COG0160@2|Bacteria	2|Bacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	dat	-	2.6.1.19	ko:K00823,ko:K20435	ko00250,ko00410,ko00525,ko00640,ko00650,ko01100,ko01120,ko01130,map00250,map00410,map00525,map00640,map00650,map01100,map01120,map01130	M00027,M00815	R00908,R01648,R11238	RC00006,RC00062,RC01514	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
PYH3_k127_7860184_2	246969.TAM4_929	2.842e-63	226.0	COG0388@1|root,arCOG00062@2157|Archaea,2XT6R@28890|Euryarchaeota,245B1@183968|Thermococci	183968|Thermococci	S	Carbon-nitrogen hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
PYH3_k127_7911801_1	386456.JQKN01000002_gene2721	2.473e-59	219.0	COG2248@1|root,arCOG00969@2157|Archaea,2XW12@28890|Euryarchaeota	28890|Euryarchaeota	S	Belongs to the UPF0282 family	-	-	-	ko:K07022	-	-	-	-	ko00000	-	-	-	Lactamase_B_2,Lactamase_B_3
PYH3_k127_7911801_2	290340.AAur_0760	1.487e-17	91.0	COG2120@1|root,COG2120@2|Bacteria,2GMXC@201174|Actinobacteria,1WAJM@1268|Micrococcaceae	201174|Actinobacteria	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
PYH3_k127_7911801_0	926566.Terro_4115	1.344e-89	309.0	COG0438@1|root,COG0438@2|Bacteria,3Y3CI@57723|Acidobacteria,2JKK7@204432|Acidobacteriia	204432|Acidobacteriia	M	glycosyl transferase group 1	-	-	-	ko:K00754	-	-	-	-	ko00000,ko01000	-	GT4	-	Glyco_transf_4,Glycos_transf_1
PYH3_k127_7911801_3	935948.KE386494_gene951	1.043e-12	72.0	COG0778@1|root,COG0778@2|Bacteria,1V4DP@1239|Firmicutes,24HBZ@186801|Clostridia,42G3X@68295|Thermoanaerobacterales	186801|Clostridia	C	Putative TM nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1905,Nitroreductase
PYH3_k127_807550_2	1370121.AUWS01000044_gene1229	1.025e-05	51.0	COG2141@1|root,COG2141@2|Bacteria,2GJRF@201174|Actinobacteria,2361K@1762|Mycobacteriaceae	201174|Actinobacteria	C	Catalyzes the reduction of the keto moiety of phthiodiolone dimycocerosates (DIM B) and glycosylated phenolphthiodiolone dimycocerosates to form the intermediate compounds phthiotriol and glycosylated phenolphthiotriol dimycocerosates during phthiocerol dimycocerosates (DIM A) and glycosylated phenolphthiocerol dimycocerosates (PGL) biosynthesis	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K14728	-	-	-	-	ko00000,ko01000	-	-	-	Bac_luciferase
PYH3_k127_807550_1	304371.MCP_2060	5.1e-41	167.0	arCOG12322@1|root,arCOG12322@2157|Archaea,2Y5I1@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_807550_0	323259.Mhun_0504	1.498e-45	173.0	COG3382@1|root,arCOG04250@2157|Archaea	2157|Archaea	S	PFAM B3 4 domain	-	-	-	-	-	-	-	-	-	-	-	-	B3_4
PYH3_k127_8095375_4	693661.Arcve_0939	6.606e-11	64.0	COG1415@1|root,arCOG04253@2157|Archaea,2XU0W@28890|Euryarchaeota,245Y8@183980|Archaeoglobi	183980|Archaeoglobi	S	Protein of unknown function (DUF763)	-	-	-	ko:K09003	-	-	-	-	ko00000	-	-	-	DUF763
PYH3_k127_8095375_0	374847.Kcr_1249	1.15e-136	447.0	COG1350@1|root,arCOG01432@2157|Archaea	2157|Archaea	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
PYH3_k127_8095375_1	192952.MM_3157	2.904e-86	300.0	COG1680@1|root,arCOG00771@2157|Archaea	2157|Archaea	V	COG1680 Beta-lactamase class C and other penicillin binding proteins	-	-	-	-	-	-	-	-	-	-	-	iAF692.Mbar_A1202	Beta-lactamase
PYH3_k127_8095375_3	227086.JGI_V11_130765	2.812e-36	143.0	KOG0080@1|root,KOG0080@2759|Eukaryota	2759|Eukaryota	S	myosin XI tail binding	RAB18	GO:0000166,GO:0001654,GO:0001775,GO:0001882,GO:0001883,GO:0002252,GO:0002263,GO:0002274,GO:0002275,GO:0002283,GO:0002366,GO:0002376,GO:0002443,GO:0002444,GO:0002446,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005789,GO:0005794,GO:0005829,GO:0005886,GO:0006810,GO:0006887,GO:0006913,GO:0006955,GO:0006996,GO:0007029,GO:0007154,GO:0007165,GO:0007264,GO:0007275,GO:0007399,GO:0007417,GO:0007420,GO:0007423,GO:0008150,GO:0009790,GO:0009792,GO:0009987,GO:0010256,GO:0012505,GO:0012506,GO:0016020,GO:0016043,GO:0016192,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0023052,GO:0030141,GO:0030659,GO:0030667,GO:0031090,GO:0031410,GO:0031982,GO:0031984,GO:0032501,GO:0032502,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032940,GO:0034389,GO:0035556,GO:0036094,GO:0036230,GO:0042119,GO:0042175,GO:0043009,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043299,GO:0043312,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044433,GO:0044444,GO:0044446,GO:0044464,GO:0045055,GO:0045321,GO:0046903,GO:0046907,GO:0048513,GO:0048731,GO:0048856,GO:0050789,GO:0050794,GO:0050896,GO:0051169,GO:0051170,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0051716,GO:0060322,GO:0065007,GO:0071782,GO:0071786,GO:0071840,GO:0071944,GO:0097159,GO:0097367,GO:0097708,GO:0098588,GO:0098805,GO:0098827,GO:0099503,GO:1901265,GO:1901363	-	ko:K07910	-	-	-	-	ko00000,ko04031,ko04131	-	-	-	Ras
PYH3_k127_8095375_2	126957.SMAR010035-PA	7.328e-41	158.0	KOG0078@1|root,KOG0078@2759|Eukaryota,38EHU@33154|Opisthokonta,3B9UK@33208|Metazoa,3CTWJ@33213|Bilateria,41WVY@6656|Arthropoda	33208|Metazoa	U	GTP binding. It is involved in the biological process described with protein transport	RAB10	GO:0000003,GO:0000166,GO:0000902,GO:0000904,GO:0001738,GO:0001775,GO:0001881,GO:0001882,GO:0001883,GO:0002009,GO:0002252,GO:0002263,GO:0002274,GO:0002275,GO:0002283,GO:0002366,GO:0002376,GO:0002443,GO:0002444,GO:0002446,GO:0002790,GO:0003006,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005768,GO:0005769,GO:0005783,GO:0005789,GO:0005794,GO:0005795,GO:0005797,GO:0005802,GO:0005829,GO:0005886,GO:0005929,GO:0006810,GO:0006886,GO:0006887,GO:0006892,GO:0006893,GO:0006904,GO:0006955,GO:0006996,GO:0007029,GO:0007154,GO:0007163,GO:0007165,GO:0007264,GO:0007265,GO:0007275,GO:0007276,GO:0007281,GO:0007292,GO:0007295,GO:0007399,GO:0007405,GO:0007409,GO:0008092,GO:0008104,GO:0008150,GO:0008152,GO:0008283,GO:0008356,GO:0009306,GO:0009653,GO:0009719,GO:0009725,GO:0009888,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010008,GO:0010033,GO:0010243,GO:0010256,GO:0010511,GO:0010512,GO:0010563,GO:0012505,GO:0012506,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0016192,GO:0016197,GO:0016328,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017022,GO:0017076,GO:0017111,GO:0017145,GO:0017157,GO:0019001,GO:0019003,GO:0019216,GO:0019220,GO:0019222,GO:0019882,GO:0019904,GO:0019953,GO:0022008,GO:0022406,GO:0022412,GO:0022414,GO:0023051,GO:0023052,GO:0030010,GO:0030030,GO:0030133,GO:0030141,GO:0030154,GO:0030182,GO:0030198,GO:0030424,GO:0030659,GO:0030667,GO:0030855,GO:0030859,GO:0031045,GO:0031090,GO:0031175,GO:0031254,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031410,GO:0031489,GO:0031982,GO:0031984,GO:0031985,GO:0032456,GO:0032482,GO:0032501,GO:0032502,GO:0032504,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032593,GO:0032794,GO:0032868,GO:0032869,GO:0032870,GO:0032879,GO:0032880,GO:0032940,GO:0032989,GO:0032990,GO:0033036,GO:0033365,GO:0034613,GO:0035556,GO:0035639,GO:0036094,GO:0036230,GO:0036445,GO:0036477,GO:0040007,GO:0042119,GO:0042175,GO:0042221,GO:0042886,GO:0042995,GO:0043001,GO:0043005,GO:0043025,GO:0043062,GO:0043112,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043299,GO:0043312,GO:0043434,GO:0044237,GO:0044260,GO:0044297,GO:0044422,GO:0044424,GO:0044425,GO:0044431,GO:0044432,GO:0044433,GO:0044440,GO:0044444,GO:0044446,GO:0044459,GO:0044464,GO:0044703,GO:0045055,GO:0045165,GO:0045175,GO:0045178,GO:0045184,GO:0045196,GO:0045200,GO:0045321,GO:0045833,GO:0045936,GO:0046677,GO:0046890,GO:0046903,GO:0046907,GO:0048103,GO:0048193,GO:0048278,GO:0048468,GO:0048471,GO:0048477,GO:0048518,GO:0048519,GO:0048523,GO:0048589,GO:0048609,GO:0048666,GO:0048667,GO:0048699,GO:0048729,GO:0048731,GO:0048812,GO:0048856,GO:0048858,GO:0048869,GO:0050789,GO:0050794,GO:0050896,GO:0051021,GO:0051046,GO:0051049,GO:0051055,GO:0051128,GO:0051174,GO:0051179,GO:0051234,GO:0051301,GO:0051640,GO:0051641,GO:0051649,GO:0051704,GO:0051716,GO:0055037,GO:0055038,GO:0055057,GO:0055059,GO:0060429,GO:0060627,GO:0061351,GO:0061564,GO:0061864,GO:0061951,GO:0065007,GO:0070201,GO:0070278,GO:0070382,GO:0070727,GO:0070887,GO:0070972,GO:0071071,GO:0071072,GO:0071236,GO:0071310,GO:0071375,GO:0071417,GO:0071495,GO:0071532,GO:0071702,GO:0071704,GO:0071705,GO:0071782,GO:0071786,GO:0071840,GO:0071944,GO:0072089,GO:0072594,GO:0072599,GO:0072657,GO:0072659,GO:0080090,GO:0090150,GO:0097051,GO:0097159,GO:0097367,GO:0097458,GO:0097708,GO:0098588,GO:0098722,GO:0098791,GO:0098805,GO:0098827,GO:0098876,GO:0099503,GO:0110010,GO:0110011,GO:0120025,GO:0120036,GO:0120039,GO:0140029,GO:0140056,GO:1901265,GO:1901363,GO:1901652,GO:1901653,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902646,GO:1902647,GO:1903053,GO:1903361,GO:1903530,GO:1903725,GO:1903726,GO:1904951,GO:1990778	-	ko:K07903	ko04144,ko04152,map04144,map04152	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	Ras
PYH3_k127_8137928_1	477974.Daud_0172	3.053e-42	164.0	COG1011@1|root,COG1011@2|Bacteria,1UIE8@1239|Firmicutes,24I5V@186801|Clostridia,262HP@186807|Peptococcaceae	186801|Clostridia	S	Haloacid dehalogenase-like hydrolase	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
PYH3_k127_8137928_2	1121904.ARBP01000002_gene6990	9.422e-30	130.0	COG0637@1|root,COG0637@2|Bacteria,4NEEH@976|Bacteroidetes,47XKJ@768503|Cytophagia	976|Bacteroidetes	S	HAD-hyrolase-like	pgmB	-	-	-	-	-	-	-	-	-	-	-	HAD_2
PYH3_k127_8137928_5	768706.Desor_4264	1.468e-06	55.0	COG1765@1|root,COG1765@2|Bacteria,1UKFU@1239|Firmicutes,25AS4@186801|Clostridia,265DF@186807|Peptococcaceae	186801|Clostridia	O	Zinc finger domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3795
PYH3_k127_8137928_0	693661.Arcve_1113	1.768e-122	410.0	COG1029@1|root,arCOG01499@2157|Archaea,2XTPW@28890|Euryarchaeota,245WE@183980|Archaeoglobi	28890|Euryarchaeota	C	Formylmethanofuran dehydrogenase, subunit B	-	-	1.2.7.12	ko:K00201	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Molybdopterin
PYH3_k127_8137928_3	309799.DICTH_0054	3.291e-28	119.0	COG0655@1|root,COG0655@2|Bacteria	2|Bacteria	S	NAD(P)H dehydrogenase (quinone) activity	wrbA	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0055114	1.6.5.2	ko:K03809	ko00130,ko01110,map00130,map01110	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	FMN_red,Flavodoxin_1,Flavodoxin_5,YjgF_endoribonc
PYH3_k127_8198070_3	8090.ENSORLP00000023195	1.898e-39	154.0	KOG0079@1|root,KOG0079@2759|Eukaryota,38GU5@33154|Opisthokonta,3BAED@33208|Metazoa,3CY45@33213|Bilateria,481II@7711|Chordata,490KR@7742|Vertebrata,49S2M@7898|Actinopterygii	33208|Metazoa	U	RAB35, member RAS oncogene family	RAB35	GO:0000166,GO:0000278,GO:0000281,GO:0000910,GO:0001882,GO:0001883,GO:0002376,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005543,GO:0005546,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005768,GO:0005769,GO:0005829,GO:0005886,GO:0005905,GO:0006810,GO:0007049,GO:0007275,GO:0007399,GO:0008021,GO:0008104,GO:0008150,GO:0008289,GO:0009719,GO:0009987,GO:0010008,GO:0010033,GO:0012505,GO:0012506,GO:0016020,GO:0016043,GO:0016192,GO:0016197,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0019882,GO:0019904,GO:0022008,GO:0022402,GO:0030030,GO:0030133,GO:0030135,GO:0030136,GO:0030139,GO:0030154,GO:0030182,GO:0030658,GO:0030659,GO:0030662,GO:0030665,GO:0030672,GO:0031090,GO:0031175,GO:0031224,GO:0031225,GO:0031253,GO:0031300,GO:0031410,GO:0031982,GO:0032456,GO:0032501,GO:0032502,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032794,GO:0033036,GO:0033365,GO:0034613,GO:0035091,GO:0035639,GO:0036010,GO:0036094,GO:0042221,GO:0042995,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0044421,GO:0044422,GO:0044424,GO:0044425,GO:0044433,GO:0044440,GO:0044444,GO:0044446,GO:0044456,GO:0044459,GO:0044463,GO:0044464,GO:0045171,GO:0045202,GO:0045334,GO:0046907,GO:0048227,GO:0048468,GO:0048666,GO:0048699,GO:0048731,GO:0048856,GO:0048869,GO:0050896,GO:0051179,GO:0051234,GO:0051301,GO:0051641,GO:0051649,GO:0051716,GO:0055037,GO:0055038,GO:0061640,GO:0070382,GO:0070727,GO:0070848,GO:0070887,GO:0071310,GO:0071363,GO:0071495,GO:0071532,GO:0071840,GO:0071944,GO:0097159,GO:0097367,GO:0097458,GO:0097708,GO:0098563,GO:0098588,GO:0098590,GO:0098793,GO:0098805,GO:0098993,GO:0099501,GO:0099503,GO:0120025,GO:0120036,GO:0120038,GO:1901265,GO:1901363,GO:1901981,GO:1902936,GO:1903047,GO:1990089,GO:1990090	-	ko:K07876	ko04144,map04144	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	Ras
PYH3_k127_8198070_2	1157490.EL26_04635	6.705e-84	301.0	COG0578@1|root,COG0578@2|Bacteria,1TQJN@1239|Firmicutes,4HAG8@91061|Bacilli,27942@186823|Alicyclobacillaceae	91061|Bacilli	C	C-terminal domain of alpha-glycerophosphate oxidase	glpD	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,DAO_C
PYH3_k127_8198070_0	224325.AF_1324	1.927e-120	405.0	COG1070@1|root,arCOG00025@2157|Archaea,2Y7I2@28890|Euryarchaeota,246ZM@183980|Archaeoglobi	183980|Archaeoglobi	G	FGGY family of carbohydrate kinases, C-terminal domain	-	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
PYH3_k127_8198070_1	1121405.dsmv_0129	1.407e-99	338.0	COG2768@1|root,COG2768@2|Bacteria,1R08Q@1224|Proteobacteria,43CRC@68525|delta/epsilon subdivisions,2X7YY@28221|Deltaproteobacteria,2MPKX@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM 4Fe-4S ferredoxin iron-sulfur binding	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
PYH3_k127_8205772_3	589924.Ferp_1532	2.347e-36	145.0	COG1980@1|root,arCOG04180@2157|Archaea,2XTI0@28890|Euryarchaeota,245YC@183980|Archaeoglobi	183980|Archaeoglobi	G	Catalyzes two subsequent steps in gluconeogenesis the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P)	fbp	-	3.1.3.11,4.1.2.13	ko:K01622	ko00010,ko00030,ko00051,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00003	R00762,R01068,R01070,R02568,R04780	RC00017,RC00438,RC00439	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_3
PYH3_k127_8205772_2	1123322.KB904735_gene1508	4.896e-47	175.0	COG0663@1|root,COG0663@2|Bacteria,2GP22@201174|Actinobacteria	201174|Actinobacteria	K	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep,Hexapep_2
PYH3_k127_8205772_1	1256908.HMPREF0373_03186	4.203e-71	250.0	COG1775@1|root,COG1924@1|root,COG1775@2|Bacteria,COG1924@2|Bacteria,1TQSD@1239|Firmicutes,2481W@186801|Clostridia,25WB2@186806|Eubacteriaceae	186801|Clostridia	I	BadF/BadG/BcrA/BcrD ATPase family	hgdC_1	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,HGD-D
PYH3_k127_8205772_0	224325.AF_1958	2.053e-101	344.0	COG1775@1|root,arCOG04464@2157|Archaea,2XZP9@28890|Euryarchaeota,246DT@183980|Archaeoglobi	183980|Archaeoglobi	E	2-hydroxyglutaryl-CoA dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	HGD-D
PYH3_k127_8205772_4	177437.HRM2_43040	4.689e-18	97.0	COG1775@1|root,COG1775@2|Bacteria,1NNW9@1224|Proteobacteria,42RTN@68525|delta/epsilon subdivisions,2WNYI@28221|Deltaproteobacteria,2MJS3@213118|Desulfobacterales	28221|Deltaproteobacteria	E	PFAM 2-hydroxyglutaryl-CoA dehydratase, D-component	-	-	1.3.7.8	ko:K04112	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R02451	RC00002,RC01839	ko00000,ko00001,ko00002,ko01000	-	-	-	HGD-D
PYH3_k127_8205772_5	649754.HMPREF0281_01170	0.0002737	51.0	COG3127@1|root,COG3127@2|Bacteria,2H37M@201174|Actinobacteria,22K1N@1653|Corynebacteriaceae	201174|Actinobacteria	Q	ABC-type antimicrobial peptide transport system, permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
PYH3_k127_8372821_6	234267.Acid_7434	4.205e-10	70.0	2DPU7@1|root,333E3@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_8372821_3	1128421.JAGA01000002_gene1226	6.025e-62	223.0	COG1606@1|root,COG1606@2|Bacteria,2NP5T@2323|unclassified Bacteria	2|Bacteria	L	tRNA processing	larE	-	4.99.1.12	ko:K06864,ko:K09121	-	-	-	-	ko00000,ko01000	-	-	-	ATP_bind_3,Asn_synthase,NAD_synthase,QueC
PYH3_k127_8372821_1	374847.Kcr_0480	5.084e-81	286.0	COG1641@1|root,arCOG02701@2157|Archaea	2157|Archaea	S	Belongs to the LarC family	-	-	4.99.1.12	ko:K09121	-	-	-	-	ko00000,ko01000	-	-	-	DUF111
PYH3_k127_8372821_2	374847.Kcr_0479	9.054e-72	251.0	COG1691@1|root,arCOG02465@2157|Archaea	2157|Archaea	S	1-(5-Phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase	-	-	-	ko:K06898	-	-	-	-	ko00000	-	-	-	AIRC
PYH3_k127_8372821_4	3983.cassava4.1_015998m	1.543e-29	125.0	COG1100@1|root,KOG0087@2759|Eukaryota,37J9I@33090|Viridiplantae,3G78Y@35493|Streptophyta,4JFNC@91835|fabids	35493|Streptophyta	U	Ras-related protein	-	GO:0000278,GO:0000281,GO:0000910,GO:0000911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005768,GO:0005829,GO:0005886,GO:0007049,GO:0008150,GO:0009504,GO:0009987,GO:0012505,GO:0016020,GO:0022402,GO:0031410,GO:0031982,GO:0032506,GO:0043226,GO:0043227,GO:0043229,GO:0044424,GO:0044444,GO:0044464,GO:0051301,GO:0061640,GO:0071944,GO:0097708,GO:1902410,GO:1903047	-	ko:K07904	ko04144,ko04961,ko04962,ko04972,map04144,map04961,map04962,map04972	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	Ras
PYH3_k127_8372821_0	909663.KI867150_gene284	5.75e-179	573.0	COG0281@1|root,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,42MDI@68525|delta/epsilon subdivisions,2WIVY@28221|Deltaproteobacteria,2MQ89@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Malic enzyme, NAD binding domain	maeB	-	1.1.1.38,1.1.1.40	ko:K00027,ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,ko02020,map00620,map00710,map01100,map01120,map01200,map02020	M00169,M00172	R00214,R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1637	Malic_M,PTA_PTB,malic
PYH3_k127_8372821_7	7070.TC003544-PA	1.761e-06	58.0	COG4886@1|root,KOG0619@2759|Eukaryota,38GPY@33154|Opisthokonta,3BFMX@33208|Metazoa,3CS8Y@33213|Bilateria,41TJ5@6656|Arthropoda,3SHWZ@50557|Insecta	33208|Metazoa	S	Leucine Rich Repeat	GPRNNB1	-	-	ko:K17256	-	-	-	-	ko00000,ko04147	-	-	-	LRR_1,LRR_5,LRR_6,LRR_8
PYH3_k127_8372821_9	700598.Niako_6757	4.721e-06	57.0	COG0546@1|root,COG0546@2|Bacteria	2|Bacteria	S	glycolate biosynthetic process	ppaX	-	3.1.3.105,3.1.3.18,3.6.1.1	ko:K01091,ko:K06019,ko:K16017,ko:K22292	ko00190,ko00520,ko00630,ko01051,ko01100,ko01110,ko01130,map00190,map00520,map00630,map01051,map01100,map01110,map01130	-	R01334,R06587,R11785	RC00017,RC00078	ko00000,ko00001,ko01000	-	-	-	HAD_2
PYH3_k127_8372821_8	589924.Ferp_0631	2.063e-06	60.0	COG1111@1|root,arCOG00872@2157|Archaea,2XTBV@28890|Euryarchaeota,245TM@183980|Archaeoglobi	183980|Archaeoglobi	L	DEAD DEAH box helicase domain protein	-	-	-	ko:K10896	ko03460,map03460	M00413	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	DEAD,ERCC4,HHH_2,HHH_5,Helicase_C
PYH3_k127_8372821_5	1196322.A370_00418	9.765e-22	102.0	COG0476@1|root,COG0476@2|Bacteria,1VIBM@1239|Firmicutes,25GG8@186801|Clostridia,36WX5@31979|Clostridiaceae	186801|Clostridia	H	ThiF family	-	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF
PYH3_k127_8394911_4	1173027.Mic7113_4252	1.529e-06	50.0	COG0383@1|root,COG0383@2|Bacteria,1G1RB@1117|Cyanobacteria,1H8DG@1150|Oscillatoriales	1117|Cyanobacteria	G	PFAM Glycosyl hydrolases family 38 C-terminal domain	ams1	-	3.2.1.24	ko:K01191	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04131	-	GH38	-	Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C
PYH3_k127_8394911_3	765420.OSCT_0878	3.001e-29	133.0	COG1402@1|root,COG1402@2|Bacteria	2|Bacteria	I	creatininase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
PYH3_k127_8394911_0	760011.Spico_1044	1.328e-89	308.0	COG0006@1|root,COG0673@1|root,COG0006@2|Bacteria,COG0673@2|Bacteria,2J6T7@203691|Spirochaetes	203691|Spirochaetes	E	Oxidoreductase family, C-terminal alpha beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
PYH3_k127_8394911_2	760011.Spico_1042	1.49e-57	209.0	COG1028@1|root,COG1028@2|Bacteria,2J8GM@203691|Spirochaetes	203691|Spirochaetes	IQ	COGs COG1028 Dehydrogenase with different specificities (related to short-chain alcohol dehydrogenase)	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
PYH3_k127_8394911_1	760011.Spico_1043	2.802e-75	261.0	COG3246@1|root,COG3246@2|Bacteria	2|Bacteria	K	L-lysine catabolic process to acetate	-	-	2.3.1.247	ko:K18013	ko00310,map00310	-	R10564	RC02728,RC03199	ko00000,ko00001,ko01000	-	-	-	BKACE
PYH3_k127_8416872_0	317936.Nos7107_1238	2.714e-66	234.0	COG0455@1|root,COG0455@2|Bacteria,1G1EJ@1117|Cyanobacteria,1HQDQ@1161|Nostocales	1117|Cyanobacteria	D	PFAM CobQ CobB MinD ParA nucleotide binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_31,ParA
PYH3_k127_8416872_1	439481.Aboo_1333	5.475e-47	189.0	COG1002@1|root,COG2810@1|root,arCOG02636@1|root,arCOG08946@1|root,arCOG02635@2157|Archaea,arCOG02636@2157|Archaea,arCOG05724@2157|Archaea,arCOG08946@2157|Archaea,2Y89V@28890|Euryarchaeota	28890|Euryarchaeota	LV	Type I restriction-modification system methyltransferase subunit	-	-	-	-	-	-	-	-	-	-	-	-	Eco57I,N6_Mtase,TaqI_C
PYH3_k127_843187_0	926566.Terro_4081	1.2e-43	175.0	COG0644@1|root,COG0644@2|Bacteria,3Y5JJ@57723|Acidobacteria,2JP4I@204432|Acidobacteriia	204432|Acidobacteriia	C	TIGRFAM geranylgeranyl reductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
PYH3_k127_8521919_0	671143.DAMO_0455	2.256e-49	197.0	COG0373@1|root,COG0373@2|Bacteria	2|Bacteria	H	glutamyl-tRNA reductase activity	hemA	GO:0005575,GO:0005623,GO:0009288,GO:0042597,GO:0042995,GO:0043226,GO:0043228,GO:0044464,GO:0055040	1.2.1.70	ko:K02407,ko:K02492,ko:K10714,ko:K15671	ko00680,ko00860,ko01051,ko01052,ko01100,ko01110,ko01120,ko01200,ko02040,map00680,map00860,map01051,map01052,map01100,map01110,map01120,map01200,map02040	M00121	R04109,R08059	RC00055,RC00149,RC00202	ko00000,ko00001,ko00002,ko01000,ko01008,ko02035	-	-	iSB619.SA_RS08420	GlutR_N,GlutR_dimer,Mpt_N,Shikimate_DH
PYH3_k127_8521919_1	351160.RCIX473	1.158e-38	162.0	COG0374@1|root,arCOG01549@2157|Archaea,2XTHE@28890|Euryarchaeota,2NAHJ@224756|Methanomicrobia	224756|Methanomicrobia	C	Belongs to the NiFe NiFeSe hydrogenase large subunit family	mvhA-1	-	1.8.98.5	ko:K14126	ko00680,map00680	-	R00019,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
PYH3_k127_8521919_2	579137.Metvu_0717	4.176e-22	106.0	COG1941@1|root,arCOG02472@2157|Archaea,2XV6A@28890|Euryarchaeota,23QG6@183939|Methanococci	183939|Methanococci	C	PFAM NADH ubiquinone oxidoreductase 20 kDa subunit	-	-	1.8.98.5	ko:K14128	ko00680,map00680	-	R00019,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	Oxidored_q6
PYH3_k127_8521919_3	641491.DND132_1391	1.918e-07	55.0	COG1908@1|root,COG1908@2|Bacteria,1RCZY@1224|Proteobacteria,42RK0@68525|delta/epsilon subdivisions,2WNZZ@28221|Deltaproteobacteria,2MGM3@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM methyl-viologen-reducing hydrogenase delta subunit	-	-	1.8.98.5,1.8.98.6	ko:K14127	ko00680,map00680	-	R00019,R11943,R11944	RC00011	ko00000,ko00001,ko01000	-	-	-	FlpD
PYH3_k127_852821_15	381764.Fnod_0796	3.048e-25	109.0	COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,2GCDP@200918|Thermotogae	200918|Thermotogae	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	GO:0003674,GO:0003824,GO:0004812,GO:0004825,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006431,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
PYH3_k127_852821_14	415426.Hbut_0470	9.055e-32	134.0	COG1938@1|root,arCOG00347@2157|Archaea,2XPV9@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM PAC2 family	-	-	-	ko:K06869	-	-	-	-	ko00000	-	-	-	PAC2
PYH3_k127_852821_3	768679.TTX_0949	5.636e-98	334.0	COG1236@1|root,arCOG00541@2157|Archaea,2XPVA@28889|Crenarchaeota	28889|Crenarchaeota	J	PFAM beta-lactamase domain protein	-	-	-	ko:K07577	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,Lactamase_B_6,RMMBL
PYH3_k127_852821_20	1365176.N186_05870	1.478e-07	62.0	COG3389@1|root,arCOG04463@2157|Archaea,2XSEQ@28889|Crenarchaeota	28889|Crenarchaeota	S	protein conserved in archaea	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_852821_21	272557.APE_0179a	2.636e-06	53.0	arCOG04057@1|root,arCOG04057@2157|Archaea	2157|Archaea	J	Belongs to the eukaryotic ribosomal protein eL38 family	rpl38e	-	-	ko:K02923	ko03010,map03010	M00177	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L38e
PYH3_k127_852821_18	572478.Vdis_2400	1.022e-13	73.0	COG1552@1|root,arCOG04049@2157|Archaea,2XRHJ@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eL40 family	rpl40e	-	-	ko:K02927	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L40e
PYH3_k127_852821_1	272557.APE_1072.1	6.115e-108	359.0	COG0074@1|root,arCOG01339@2157|Archaea,2XPW3@28889|Crenarchaeota	28889|Crenarchaeota	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA,Succ_CoA_lig
PYH3_k127_852821_2	926569.ANT_20580	8.839e-105	353.0	COG0045@1|root,COG0045@2|Bacteria,2G68A@200795|Chloroflexi	200795|Chloroflexi	F	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
PYH3_k127_852821_13	604354.TSIB_0713	1.571e-32	132.0	COG1522@1|root,arCOG01118@2157|Archaea,2XWRI@28890|Euryarchaeota,24403@183968|Thermococci	183968|Thermococci	K	helix_turn_helix, cAMP Regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_Crp_2,MarR_2
PYH3_k127_852821_16	933801.Ahos_0633	5.58e-22	105.0	COG0195@1|root,arCOG01761@2157|Archaea,2XQQR@28889|Crenarchaeota	28889|Crenarchaeota	J	Transcription elongation factor	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_852821_5	192952.MM_0114	2.49e-63	235.0	COG0585@1|root,arCOG04252@2157|Archaea,2XUTK@28890|Euryarchaeota,2N928@224756|Methanomicrobia	224756|Methanomicrobia	J	Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs	truD	-	5.4.99.27	ko:K06176	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruD
PYH3_k127_852821_10	342949.PNA2_0125	2.778e-37	147.0	COG1990@1|root,arCOG04228@2157|Archaea,2XYRE@28890|Euryarchaeota,24457@183968|Thermococci	183968|Thermococci	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	-	3.1.1.29	ko:K04794	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	PTH2
PYH3_k127_852821_8	368408.Tpen_0783	8.928e-41	166.0	COG0644@1|root,arCOG00570@2157|Archaea,2XQUP@28889|Crenarchaeota	28889|Crenarchaeota	C	Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains	-	-	-	-	-	-	-	-	-	-	-	-	Lycopene_cycl,NAD_binding_8,Pyr_redox_2
PYH3_k127_852821_11	529709.PYCH_10220	1.884e-34	135.0	COG1594@1|root,arCOG00579@2157|Archaea,2XXU7@28890|Euryarchaeota,2444S@183968|Thermococci	183968|Thermococci	K	Belongs to the archaeal rpoM eukaryotic RPA12 RPB9 RPC11 RNA polymerase family	-	-	-	ko:K03057	ko01100,map01100	-	-	-	br01611,ko00000,ko03021	-	-	-	RNA_POL_M_15KD,TFIIS_C
PYH3_k127_852821_17	246969.TAM4_838	7.03e-16	83.0	arCOG05836@1|root,arCOG05836@2157|Archaea,2Y48U@28890|Euryarchaeota,2444T@183968|Thermococci	183968|Thermococci	S	Ribonuclease III	-	-	-	-	-	-	-	-	-	-	-	-	Ribonucleas_3_2
PYH3_k127_852821_19	195522.BD01_0332	7.626e-13	74.0	COG1761@1|root,arCOG04111@2157|Archaea,2XZHA@28890|Euryarchaeota,244CK@183968|Thermococci	183968|Thermococci	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoL	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03056	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_L_2
PYH3_k127_852821_12	529709.PYCH_19250	1.056e-32	135.0	COG1096@1|root,arCOG00676@2157|Archaea,2XYYA@28890|Euryarchaeota,243T0@183968|Thermococci	183968|Thermococci	J	Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs	csl4	-	-	ko:K07573	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	ECR1_N,EXOSC1
PYH3_k127_852821_6	523850.TON_1935	7.175e-49	182.0	COG2263@1|root,arCOG00910@2157|Archaea,2XU4P@28890|Euryarchaeota,24393@183968|Thermococci	183968|Thermococci	J	Conserved hypothetical protein 95	-	-	-	ko:K07579	-	-	-	-	ko00000	-	-	-	MTS,PrmA
PYH3_k127_852821_0	368408.Tpen_0112	1.605e-158	511.0	COG0148@1|root,arCOG01169@2157|Archaea,2XPZ6@28889|Crenarchaeota	28889|Crenarchaeota	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
PYH3_k127_852821_7	573064.Mefer_0789	7.005e-46	172.0	COG0197@1|root,arCOG04113@2157|Archaea,2XTHT@28890|Euryarchaeota,23QNQ@183939|Methanococci	183939|Methanococci	J	Belongs to the universal ribosomal protein uL16 family	rpl10e	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02866	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
PYH3_k127_852821_4	391623.TERMP_00982	8.852e-90	312.0	COG1163@1|root,arCOG00358@2157|Archaea,2XTYK@28890|Euryarchaeota,242M3@183968|Thermococci	183968|Thermococci	S	gtp1 obg	-	-	-	ko:K06944	-	-	-	-	ko00000	-	-	-	MMR_HSR1,MMR_HSR1_Xtn,TGS
PYH3_k127_852821_9	1220534.B655_2050	1.6e-38	152.0	COG2890@1|root,arCOG00109@2157|Archaea,2XWJZ@28890|Euryarchaeota,23P23@183925|Methanobacteria	183925|Methanobacteria	Q	Lysine methyltransferase	-	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS
PYH3_k127_852821_22	1094980.Mpsy_2772	5.155e-05	48.0	COG0030@1|root,arCOG04131@2157|Archaea,2XU1Q@28890|Euryarchaeota,2N9HP@224756|Methanomicrobia	224756|Methanomicrobia	J	Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
PYH3_k127_8569225_1	572546.Arcpr_0221	3.107e-41	156.0	COG0143@1|root,arCOG00810@2157|Archaea,2XTG5@28890|Euryarchaeota,245Z0@183980|Archaeoglobi	183980|Archaeoglobi	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
PYH3_k127_8569225_5	391623.TERMP_00260	8.98e-06	54.0	COG1522@1|root,arCOG01117@2157|Archaea,2Y1HH@28890|Euryarchaeota,244RQ@183968|Thermococci	183968|Thermococci	K	Lrp/AsnC ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
PYH3_k127_8569225_3	246437.XP_006169885.1	4.265e-37	147.0	KOG0084@1|root,KOG0084@2759|Eukaryota	2759|Eukaryota	S	GTPase activity	RAB43	GO:0000139,GO:0001894,GO:0002065,GO:0002067,GO:0002376,GO:0003674,GO:0003824,GO:0003924,GO:0005096,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005768,GO:0005794,GO:0005802,GO:0006810,GO:0006950,GO:0006952,GO:0006955,GO:0006996,GO:0007030,GO:0007154,GO:0007165,GO:0007264,GO:0007265,GO:0008047,GO:0008150,GO:0009888,GO:0009987,GO:0010033,GO:0010256,GO:0012505,GO:0016020,GO:0016032,GO:0016043,GO:0016192,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0019058,GO:0019068,GO:0023052,GO:0030139,GO:0030154,GO:0030234,GO:0030695,GO:0030855,GO:0031090,GO:0031410,GO:0031982,GO:0031984,GO:0032482,GO:0032501,GO:0032502,GO:0032588,GO:0034097,GO:0034341,GO:0035526,GO:0035556,GO:0035883,GO:0036477,GO:0042221,GO:0042592,GO:0043025,GO:0043085,GO:0043087,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043547,GO:0044093,GO:0044297,GO:0044403,GO:0044419,GO:0044422,GO:0044424,GO:0044431,GO:0044444,GO:0044446,GO:0044464,GO:0045087,GO:0045202,GO:0045335,GO:0045595,GO:0048856,GO:0048869,GO:0048871,GO:0048872,GO:0048873,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050896,GO:0051179,GO:0051234,GO:0051336,GO:0051345,GO:0051704,GO:0051716,GO:0060249,GO:0060429,GO:0060589,GO:0060786,GO:0065007,GO:0065008,GO:0065009,GO:0070887,GO:0071310,GO:0071345,GO:0071346,GO:0071840,GO:0090382,GO:0097458,GO:0097708,GO:0098588,GO:0098772,GO:0098791,GO:1901998	-	ko:K07874,ko:K07910,ko:K07930,ko:K17047	ko05134,map05134	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	Ras
PYH3_k127_8569225_2	316274.Haur_2917	1.692e-38	159.0	COG4805@1|root,COG4805@2|Bacteria,2G8D3@200795|Chloroflexi	200795|Chloroflexi	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_8569225_0	273116.14324753	3.453e-55	206.0	COG0010@1|root,arCOG01700@2157|Archaea,2XTEP@28890|Euryarchaeota,241N8@183967|Thermoplasmata	183967|Thermoplasmata	E	Arginase family	-	-	3.5.3.1,3.5.3.11	ko:K01476,ko:K01480	ko00220,ko00330,ko01100,ko01110,ko01130,ko01230,ko05146,map00220,map00330,map01100,map01110,map01130,map01230,map05146	M00029,M00133,M00134	R00551,R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
PYH3_k127_8569225_6	1163730.FFONT_1214	2.691e-05	55.0	COG1340@1|root,arCOG01159@2157|Archaea	2157|Archaea	D	archaeal coiled-coil protein	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_8569225_4	498848.TaqDRAFT_3708	1.165e-06	57.0	COG0006@1|root,COG0006@2|Bacteria,1WIH7@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	PFAM Metallopeptidase family M24	-	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
PYH3_k127_8575540_6	335543.Sfum_2411	1.677e-11	66.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,42NB6@68525|delta/epsilon subdivisions,2WIWE@28221|Deltaproteobacteria,2MR9A@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	Trypsin	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
PYH3_k127_8575540_5	547042.BACCOPRO_00839	8.34e-16	81.0	COG0265@1|root,COG0265@2|Bacteria,4NFCS@976|Bacteroidetes,2FMUA@200643|Bacteroidia,4ANIK@815|Bacteroidaceae	976|Bacteroidetes	O	Psort location Periplasmic, score	htrA	-	-	-	-	-	-	-	-	-	-	-	PDZ_1,PDZ_2,Trypsin_2
PYH3_k127_8575540_4	1459636.NTE_03333	4.922e-19	94.0	COG1733@1|root,arCOG01057@2157|Archaea	2157|Archaea	K	Transcriptional regulator	-	-	-	ko:K07332	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	-
PYH3_k127_8575540_1	1121430.JMLG01000036_gene166	1.231e-56	203.0	COG2109@1|root,COG2109@2|Bacteria,1V70U@1239|Firmicutes,24JNB@186801|Clostridia,261TW@186807|Peptococcaceae	186801|Clostridia	H	PFAM ATP corrinoid adenosyltransferase BtuR CobO CobP	-	-	2.5.1.17	ko:K19221	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	CobA_CobO_BtuR
PYH3_k127_8575540_3	868131.MSWAN_0660	1.925e-38	151.0	COG0537@1|root,COG1992@1|root,arCOG00021@2157|Archaea,arCOG00419@2157|Archaea,2XWGT@28890|Euryarchaeota	28890|Euryarchaeota	F	COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases	hit1	-	2.5.1.3,2.7.7.53,3.6.1.17	ko:K01518,ko:K02503,ko:K19710,ko:K21220	ko00230,ko00240,ko00730,ko01100,map00230,map00240,map00730,map01100	-	R00126,R00184,R00969,R01232,R01618,R02805,R03223,R10712	RC00002,RC00224,RC02753,RC02795,RC03255,RC03397	ko00000,ko00001,ko01000,ko04147	-	-	-	HIT
PYH3_k127_8575540_2	309801.trd_A0857	4.436e-39	155.0	COG1402@1|root,COG1402@2|Bacteria,2G7B0@200795|Chloroflexi,27Y94@189775|Thermomicrobia	189775|Thermomicrobia	S	Creatinine amidohydrolase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
PYH3_k127_8575540_0	1191523.MROS_1378	2.445e-159	509.0	COG0499@1|root,COG0499@2|Bacteria	2|Bacteria	H	adenosylhomocysteinase activity	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
PYH3_k127_8591759_1	1128421.JAGA01000002_gene1228	4.339e-25	109.0	COG1801@1|root,COG1801@2|Bacteria,2NPRG@2323|unclassified Bacteria	2|Bacteria	S	Protein of unknown function DUF72	yecE	-	-	-	-	-	-	-	-	-	-	-	DUF72
PYH3_k127_8591759_0	304371.MCP_2463	1.046e-99	334.0	COG2006@1|root,arCOG02446@2157|Archaea,2XV9B@28890|Euryarchaeota	28890|Euryarchaeota	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
PYH3_k127_8601188_1	643648.Slip_1595	2.131e-46	180.0	COG1143@1|root,COG1143@2|Bacteria,1UI0U@1239|Firmicutes,25E9M@186801|Clostridia,42KNQ@68298|Syntrophomonadaceae	186801|Clostridia	C	PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_6
PYH3_k127_8601188_0	1237500.ANBA01000009_gene1044	7.047e-104	351.0	COG3214@1|root,COG3214@2|Bacteria,2GJM7@201174|Actinobacteria,4EGXC@85012|Streptosporangiales	201174|Actinobacteria	S	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_42
PYH3_k127_8601188_2	697281.Mahau_2090	1.485e-12	72.0	COG0662@1|root,COG0662@2|Bacteria	2|Bacteria	G	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
PYH3_k127_8606817_10	399550.Smar_1045	4.037e-44	169.0	COG1102@1|root,arCOG01037@2157|Archaea,2XQ8J@28889|Crenarchaeota	28889|Crenarchaeota	F	Belongs to the cytidylate kinase family. Type 2 subfamily	cmk	-	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin2
PYH3_k127_8606817_13	415426.Hbut_1328	9.088e-28	114.0	COG2163@1|root,arCOG04167@2157|Archaea,2XQT9@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eL14 family	rpl14e	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02875	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14e
PYH3_k127_8606817_17	1094980.Mpsy_1119	0.0003059	46.0	COG0130@1|root,arCOG00987@2157|Archaea,2XTUE@28890|Euryarchaeota,2N99I@224756|Methanomicrobia	224756|Methanomicrobia	J	Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs	truB	-	5.4.99.25	ko:K03177,ko:K11131	ko03008,map03008	M00425	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03016,ko03032	-	-	-	DKCLD,PUA,TruB_C_2,TruB_N
PYH3_k127_8606817_0	386456.JQKN01000001_gene1733	1.179e-110	364.0	COG0130@1|root,arCOG00987@2157|Archaea,2XTUE@28890|Euryarchaeota,23NQV@183925|Methanobacteria	183925|Methanobacteria	J	Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs	truB	-	-	ko:K11131	ko03008,map03008	M00425	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03032	-	-	-	DKCLD,PUA,TruB_C_2,TruB_N
PYH3_k127_8606817_8	694429.Pyrfu_1972	1.552e-50	183.0	COG0099@1|root,arCOG01722@2157|Archaea,2XQBF@28889|Crenarchaeota	28889|Crenarchaeota	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rps13	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
PYH3_k127_8606817_9	453591.Igni_0181	1.594e-44	171.0	COG0522@1|root,arCOG04239@2157|Archaea,2XQCT@28889|Crenarchaeota	28889|Crenarchaeota	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rps4	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
PYH3_k127_8606817_7	415426.Hbut_0529	3.342e-57	207.0	COG0100@1|root,arCOG04240@2157|Archaea,2XQCR@28889|Crenarchaeota	28889|Crenarchaeota	J	Located on the platform of the 30S subunit	rps11	GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
PYH3_k127_8606817_6	1041930.Mtc_1534	2.021e-62	226.0	COG0202@1|root,arCOG04241@2157|Archaea,2XTQB@28890|Euryarchaeota,2N911@224756|Methanomicrobia	224756|Methanomicrobia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoD	-	2.7.7.6	ko:K03047	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	Fer4,Fer4_9,RNA_pol_A_bac,RNA_pol_L
PYH3_k127_8606817_16	387631.Asulf_00628	2.944e-21	97.0	COG1727@1|root,arCOG00780@2157|Archaea,2XZ6R@28890|Euryarchaeota,246C1@183980|Archaeoglobi	183980|Archaeoglobi	J	Belongs to the eukaryotic ribosomal protein eL18 family	rpl18e	-	-	ko:K02883	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18,Ribosomal_L27A
PYH3_k127_8606817_14	1042877.GQS_04695	4.076e-27	116.0	COG0102@1|root,arCOG04242@2157|Archaea,2XWN6@28890|Euryarchaeota,243ZW@183968|Thermococci	183968|Thermococci	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rpl13	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
PYH3_k127_8606817_11	224719.Abm4_1237	2.994e-43	161.0	COG0088@1|root,arCOG04243@2157|Archaea,2XWK0@28890|Euryarchaeota,23PIA@183925|Methanobacteria	183925|Methanobacteria	J	Belongs to the universal ribosomal protein uS9 family	rps9	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
PYH3_k127_8606817_15	272844.PAB7131	5.942e-23	103.0	COG1644@1|root,arCOG04244@2157|Archaea,2Y03I@28890|Euryarchaeota,244I0@183968|Thermococci	183968|Thermococci	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoN	GO:0000428,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0008270,GO:0030880,GO:0032991,GO:0043167,GO:0043169,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03058	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_N
PYH3_k127_8606817_4	399550.Smar_0820	4.242e-75	257.0	COG0052@1|root,arCOG04245@2157|Archaea,2XPP9@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the universal ribosomal protein uS2 family	rps2	GO:0000028,GO:0000447,GO:0000460,GO:0000461,GO:0000462,GO:0000466,GO:0000469,GO:0000478,GO:0000479,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0031123,GO:0031125,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043628,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
PYH3_k127_8606817_3	35128.Thaps2376	4.836e-89	303.0	COG1577@1|root,KOG1511@2759|Eukaryota,2XDVQ@2836|Bacillariophyta	2836|Bacillariophyta	I	GHMP kinases C terminal	-	-	2.7.1.36	ko:K00869	ko00900,ko01100,ko01110,ko01130,ko04146,map00900,map01100,map01110,map01130,map04146	M00095	R02245	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
PYH3_k127_8606817_2	593117.TGAM_1657	2.457e-89	310.0	COG0043@1|root,arCOG01671@2157|Archaea,2XUDW@28890|Euryarchaeota,242S6@183968|Thermococci	183968|Thermococci	H	3-octaprenyl-4-hydroxybenzoate carboxy-lyase	-	-	-	-	-	-	-	-	-	-	-	-	UbiD
PYH3_k127_8606817_1	868131.MSWAN_2414	2.301e-107	361.0	COG1679@1|root,arCOG04278@2157|Archaea,2XTY6@28890|Euryarchaeota,23NR8@183925|Methanobacteria	183925|Methanobacteria	S	Protein of unknown function (DUF521)	-	-	-	ko:K09123	-	-	-	-	ko00000	-	-	-	DUF521
PYH3_k127_8606817_12	69014.TK1248	3.966e-37	144.0	COG1786@1|root,arCOG04279@2157|Archaea,2XYXJ@28890|Euryarchaeota,2445F@183968|Thermococci	183968|Thermococci	C	Belongs to the UPF0107 family	-	-	-	ko:K09128	-	-	-	-	ko00000	-	-	-	DUF126
PYH3_k127_8606817_5	693661.Arcve_0601	2.583e-63	225.0	COG1304@1|root,arCOG00613@2157|Archaea,2XT6H@28890|Euryarchaeota,245R4@183980|Archaeoglobi	183980|Archaeoglobi	H	Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)	fni	-	5.3.3.2	ko:K01823	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00095,M00096,M00364,M00365,M00366,M00367	R01123	RC00455	ko00000,ko00001,ko00002,ko01000	-	-	-	FMN_dh
PYH3_k127_8612568_3	589924.Ferp_1294	1.581e-172	556.0	COG1690@1|root,arCOG04246@2157|Archaea,2XTIC@28890|Euryarchaeota,245RW@183980|Archaeoglobi	183980|Archaeoglobi	L	Belongs to the RtcB family	rtcB	-	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
PYH3_k127_8612568_7	386456.JQKN01000001_gene1764	1.641e-44	173.0	COG2106@1|root,arCOG04069@2157|Archaea,2XSZI@28890|Euryarchaeota,23NTH@183925|Methanobacteria	183925|Methanobacteria	S	Putative RNA methyltransferase	-	-	-	ko:K09142	-	-	-	-	ko00000	-	-	-	Methyltrn_RNA_3
PYH3_k127_8612568_8	304371.MCP_1226	1.715e-38	146.0	COG0051@1|root,arCOG01758@2157|Archaea,2XXV8@28890|Euryarchaeota,2N9T3@224756|Methanomicrobia	224756|Methanomicrobia	J	Involved in the binding of tRNA to the ribosomes	rps10	-	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
PYH3_k127_8612568_2	694429.Pyrfu_0229	2.929e-183	582.0	COG5256@1|root,arCOG01561@2157|Archaea,2XPNT@28889|Crenarchaeota	28889|Crenarchaeota	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03231	ko03013,ko05134,map03013,map05134	-	-	-	ko00000,ko00001,ko03012,ko03016,ko03019,ko04131,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
PYH3_k127_8612568_5	633148.Tagg_1400	5.138e-66	231.0	COG0049@1|root,arCOG04254@2157|Archaea,2XPUU@28889|Crenarchaeota	28889|Crenarchaeota	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center	rps7	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
PYH3_k127_8612568_6	368408.Tpen_0281	2.606e-58	205.0	COG0048@1|root,arCOG04255@2157|Archaea,2XQ79@28889|Crenarchaeota	28889|Crenarchaeota	J	With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits	rps12	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
PYH3_k127_8612568_9	1459636.NTE_02747	2.103e-35	139.0	COG0195@1|root,arCOG01760@2157|Archaea,41SJQ@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Participates in transcription termination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_2
PYH3_k127_8612568_10	176275.XP_008598733.1	5.925e-12	70.0	COG1911@1|root,KOG2988@2759|Eukaryota,3A3EW@33154|Opisthokonta,3P3X3@4751|Fungi,3QWQH@4890|Ascomycota,21AVV@147550|Sordariomycetes,3TIKG@5125|Hypocreales	4751|Fungi	J	Ribosomal protein L30	RPL30	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0015934,GO:0016070,GO:0016072,GO:0019219,GO:0019222,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0030627,GO:0031323,GO:0031324,GO:0032991,GO:0033119,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036002,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043484,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045934,GO:0046483,GO:0048024,GO:0048025,GO:0048519,GO:0048523,GO:0050684,GO:0050686,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903311,GO:1903312,GO:1990904	-	ko:K02908	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L7Ae
PYH3_k127_8612568_4	272844.PAB0425	1.524e-120	398.0	COG0086@1|root,arCOG04256@2157|Archaea,2XTJ6@28890|Euryarchaeota,242U8@183968|Thermococci	183968|Thermococci	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA2	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03042	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb1_5
PYH3_k127_8612568_0	1365176.N186_02335	0.0	1096.0	COG0086@1|root,arCOG04257@2157|Archaea,2XPT5@28889|Crenarchaeota	28889|Crenarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA1	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03041	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
PYH3_k127_8612568_1	391623.TERMP_00241	4.735e-265	830.0	COG0085@1|root,arCOG01762@2157|Archaea,2XU1X@28890|Euryarchaeota,24327@183968|Thermococci	183968|Thermococci	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K13798	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_4,RNA_pol_Rpb2_5,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
PYH3_k127_8670468_0	1183438.GKIL_2755	3.032e-88	307.0	COG1032@1|root,COG1032@2|Bacteria,1G3ZK@1117|Cyanobacteria	1117|Cyanobacteria	C	TIGRFAM Hopanoid biosynthesis associated radical SAM protein HpnJ	-	-	1.21.98.3	ko:K04034	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R06268,R06269,R06270	RC00741,RC01491,RC01492	ko00000,ko00001,ko01000	-	-	-	B12-binding,Radical_SAM
PYH3_k127_8670468_1	868131.MSWAN_1145	1.62e-06	55.0	COG1149@1|root,arCOG04073@2157|Archaea	2157|Archaea	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CbiA,Fer4
PYH3_k127_8686703_1	309800.C498_03934	5.067e-05	56.0	arCOG01792@1|root,arCOG01792@2157|Archaea,2XW2T@28890|Euryarchaeota,23U9Q@183963|Halobacteria	183963|Halobacteria	Q	COG0500 SAM-dependent methyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
PYH3_k127_8686927_1	1128421.JAGA01000002_gene371	5.903e-84	291.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,2NNW5@2323|unclassified Bacteria	2|Bacteria	C	synthetase (ADP forming), alpha	-	-	6.2.1.13	ko:K01905,ko:K09181,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,Acetyltransf_1,CoA_binding_2,Succ_CoA_lig
PYH3_k127_8686927_2	453591.Igni_1372	5.429e-61	221.0	COG1405@1|root,arCOG01981@2157|Archaea,2XQ1T@28889|Crenarchaeota	28889|Crenarchaeota	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	tfb	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
PYH3_k127_8686927_0	272844.PAB0776	5.953e-116	388.0	COG0677@1|root,arCOG00252@2157|Archaea,2XUJT@28890|Euryarchaeota,243IX@183968|Thermococci	183968|Thermococci	M	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus	-	-	-	-	-	-	-	-	-	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
PYH3_k127_8686927_3	1125863.JAFN01000001_gene888	2.381e-31	132.0	COG2945@1|root,COG2945@2|Bacteria,1MUDY@1224|Proteobacteria,42TXX@68525|delta/epsilon subdivisions,2WQBC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	hydrolase of the alpha beta superfamily	-	-	-	ko:K07018	-	-	-	-	ko00000	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4,Peptidase_S15
PYH3_k127_8686927_4	645465.ACUR01000031_gene4951	4.596e-11	70.0	COG0454@1|root,COG0456@2|Bacteria,2IHRD@201174|Actinobacteria	201174|Actinobacteria	K	Acetyltransferase (GNAT) family	ypeA	-	2.3.1.1	ko:K22477	ko00220,ko01210,ko01230,map00220,map01210,map01230	M00028	R00259	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_1
PYH3_k127_871579_1	1041930.Mtc_2447	1.862e-121	402.0	COG0183@1|root,arCOG01278@2157|Archaea,2XT38@28890|Euryarchaeota,2N94P@224756|Methanomicrobia	224756|Methanomicrobia	I	PFAM Thiolase	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iAF692.Mbar_A0550	Thiolase_C,Thiolase_N
PYH3_k127_871579_4	309801.trd_A0053	0.0004591	45.0	COG1598@1|root,COG1598@2|Bacteria	2|Bacteria	N	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	HicB_lk_antitox
PYH3_k127_871579_0	399550.Smar_1241	7.061e-132	436.0	COG1042@1|root,arCOG01340@2157|Archaea,2XPR9@28889|Crenarchaeota	28889|Crenarchaeota	C	PFAM CoA-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
PYH3_k127_871579_3	673860.AciM339_0553	7.106e-09	60.0	COG1522@1|root,arCOG01117@2157|Archaea,2XZY2@28890|Euryarchaeota,3F3G3@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	Lrp/AsnC ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
PYH3_k127_871579_2	481448.Minf_0021	1.599e-24	118.0	COG0045@1|root,COG1042@1|root,COG1670@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG1670@2|Bacteria,46S9M@74201|Verrucomicrobia,37GBQ@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	CJ	CoA binding domain	-	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
PYH3_k127_8736268_2	351160.LRC48	2.382e-24	117.0	COG3372@1|root,arCOG04356@2157|Archaea,2XSTX@28890|Euryarchaeota,2N95G@224756|Methanomicrobia	224756|Methanomicrobia	L	Protein of unknown function (DUF790)	-	-	-	ko:K09744	-	-	-	-	ko00000	-	-	-	DUF790
PYH3_k127_8736268_0	374847.Kcr_1603	2.482e-105	360.0	COG0016@1|root,arCOG00410@2157|Archaea	2157|Archaea	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily	pheS	GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2d
PYH3_k127_8736268_1	765177.Desmu_0849	1.348e-41	161.0	COG0072@1|root,arCOG00412@2157|Archaea,2XPRQ@28889|Crenarchaeota	28889|Crenarchaeota	J	Phenylalanyl-tRNA synthetase, beta subunit	pheT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,tRNA-synt_2d
PYH3_k127_8771078_3	1121468.AUBR01000028_gene1523	3.22e-32	138.0	COG1014@1|root,COG1014@2|Bacteria,1VV4V@1239|Firmicutes,25039@186801|Clostridia	186801|Clostridia	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	POR
PYH3_k127_8771078_0	706587.Desti_1357	1.345e-152	503.0	COG4231@1|root,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,42Q2C@68525|delta/epsilon subdivisions,2WKNN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	-	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,POR_N,TPP_enzyme_C
PYH3_k127_8771078_1	682795.AciX8_0803	2.197e-143	467.0	COG0334@1|root,COG0334@2|Bacteria,3Y3B4@57723|Acidobacteria,2JI4Q@204432|Acidobacteriia	204432|Acidobacteriia	E	Belongs to the Glu Leu Phe Val dehydrogenases family	-	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
PYH3_k127_8771078_2	760568.Desku_0475	2.02e-82	293.0	COG1042@1|root,COG1042@2|Bacteria,1UEDG@1239|Firmicutes,24CA8@186801|Clostridia,264E0@186807|Peptococcaceae	186801|Clostridia	C	Succinyl-CoA ligase like flavodoxin domain	-	-	6.2.1.13	ko:K01905	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	CoA_binding_2,Succ_CoA_lig
PYH3_k127_8797455_0	660470.Theba_0766	1.011e-156	519.0	COG3808@1|root,COG3808@2|Bacteria,2GDSS@200918|Thermotogae	200918|Thermotogae	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	-	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
PYH3_k127_8797455_3	1041930.Mtc_2471	6.738e-23	104.0	COG1153@1|root,arCOG02674@2157|Archaea,2XXYM@28890|Euryarchaeota,2NB08@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM molydopterin dinucleotide-binding region	fwdD-1	-	1.2.7.12	ko:K00203	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060,R11743	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Molydop_binding
PYH3_k127_8797455_2	765177.Desmu_0894	1.661e-30	133.0	COG1665@1|root,arCOG01831@2157|Archaea,2XQ0X@28889|Crenarchaeota	28889|Crenarchaeota	S	DNA polymerase beta domain protein region	-	-	-	ko:K09717	-	-	-	-	ko00000	-	-	-	-
PYH3_k127_8797455_1	420247.Msm_1058	6.307e-36	149.0	COG1665@1|root,arCOG01831@2157|Archaea,2XVY6@28890|Euryarchaeota,23NTJ@183925|Methanobacteria	183925|Methanobacteria	S	DNA polymerase beta domain protein region	-	-	-	ko:K09717	-	-	-	-	ko00000	-	-	-	-
PYH3_k127_8883247_1	1280944.HY17_03710	8.604e-62	234.0	COG0457@1|root,COG1680@1|root,COG0457@2|Bacteria,COG1680@2|Bacteria,1MVPR@1224|Proteobacteria,2U5VQ@28211|Alphaproteobacteria,43Y8E@69657|Hyphomonadaceae	28211|Alphaproteobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,DUF3471
PYH3_k127_8883247_0	390874.Tpet_1772	4.376e-193	626.0	COG1743@1|root,COG1743@2|Bacteria	2|Bacteria	L	DNA methylAse	-	-	-	-	-	-	-	-	-	-	-	-	DUF1156,N6_N4_Mtase
PYH3_k127_8883247_2	1227454.C446_01021	1.161e-34	141.0	COG1874@1|root,arCOG04085@2157|Archaea,2XSU6@28890|Euryarchaeota,23UX4@183963|Halobacteria	183963|Halobacteria	G	COG1874 Beta-galactosidase	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_895453_1	589924.Ferp_0245	1.424e-88	299.0	COG0358@1|root,arCOG04281@2157|Archaea,2XTHB@28890|Euryarchaeota,245WB@183980|Archaeoglobi	183980|Archaeoglobi	L	DNA primase	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	Toprim_4
PYH3_k127_895453_6	386456.JQKN01000002_gene2757	2.972e-08	57.0	COG0358@1|root,arCOG04281@2157|Archaea,2XTHB@28890|Euryarchaeota,23NJ5@183925|Methanobacteria	183925|Methanobacteria	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	Toprim_4
PYH3_k127_895453_5	1151117.AJLF01000001_gene778	8.427e-12	71.0	COG1658@1|root,arCOG01486@2157|Archaea,2Y18J@28890|Euryarchaeota,2448C@183968|Thermococci	183968|Thermococci	L	UPF0292 protein	-	-	-	-	-	-	-	-	-	-	-	-	Toprim
PYH3_k127_895453_0	694429.Pyrfu_0404	2.66e-103	348.0	COG0162@1|root,arCOG01886@2157|Archaea,2XPU5@28889|Crenarchaeota	28889|Crenarchaeota	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0004832,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	tRNA-synt_1b
PYH3_k127_895453_3	192952.MM_3150	9.297e-56	206.0	COG2520@1|root,arCOG10124@2157|Archaea,2XTPV@28890|Euryarchaeota,2N953@224756|Methanomicrobia	224756|Methanomicrobia	J	S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe)	taw2	-	2.5.1.114	ko:K07055	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Met_10
PYH3_k127_895453_4	246969.TAM4_1132	1.7e-29	127.0	COG1986@1|root,arCOG01223@2157|Archaea,2XWGY@28890|Euryarchaeota,2441Z@183968|Thermococci	183968|Thermococci	F	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.7.3	ko:K02201	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
PYH3_k127_895453_2	374847.Kcr_1153	2.96e-82	286.0	COG4046@1|root,arCOG04181@2157|Archaea	2157|Archaea	S	DUF1512 domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF1512
PYH3_k127_8974022_2	224325.AF_0464	4.392e-69	249.0	COG0644@1|root,arCOG00570@2157|Archaea,2XU3J@28890|Euryarchaeota,245QU@183980|Archaeoglobi	183980|Archaeoglobi	C	Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains	-	-	1.3.1.101,1.3.7.11	ko:K17830	ko00564,map00564	-	R10325,R10326,R10331	RC03134	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3
PYH3_k127_8974022_8	272844.PAB3048	1.273e-07	55.0	COG1145@1|root,arCOG00958@2157|Archaea,2Y1CC@28890|Euryarchaeota,244IB@183968|Thermococci	183968|Thermococci	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
PYH3_k127_8974022_4	186497.PF0122	1.435e-54	203.0	COG1184@1|root,arCOG01124@2157|Archaea,2XUFM@28890|Euryarchaeota,2434J@183968|Thermococci	183968|Thermococci	J	Belongs to the eIF-2B alpha beta delta subunits family	-	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0019509,GO:0019752,GO:0043094,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046523,GO:0071265,GO:0071267,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.29	ko:K18237	-	-	-	-	ko00000,ko01000	-	-	-	IF-2B
PYH3_k127_8974022_0	399550.Smar_1357	2.187e-88	305.0	COG1184@1|root,arCOG01124@2157|Archaea,2XPZN@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eIF-2B alpha beta delta subunits family	-	-	5.3.1.29	ko:K18237	-	-	-	-	ko00000,ko01000	-	-	-	IF-2B
PYH3_k127_8974022_10	272557.APE_0537a	5.823e-06	58.0	COG4352@1|root,arCOG01013@2157|Archaea,2XR7C@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eL13 family	rpl13e	-	-	ko:K02873	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13e
PYH3_k127_8974022_6	269797.Mbar_A0194	1.244e-44	170.0	COG0638@1|root,arCOG00970@2157|Archaea,2XUIZ@28890|Euryarchaeota,2N9GY@224756|Methanomicrobia	224756|Methanomicrobia	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	psmB	-	3.4.25.1	ko:K03433	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
PYH3_k127_8974022_5	1123288.SOV_7c00260	1.775e-51	195.0	COG1856@1|root,COG1856@2|Bacteria,1V23U@1239|Firmicutes,4H3G8@909932|Negativicutes	909932|Negativicutes	S	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
PYH3_k127_8974022_3	744872.Spica_1727	1.348e-55	203.0	COG0095@1|root,COG0095@2|Bacteria,2J7CV@203691|Spirochaetes	203691|Spirochaetes	H	Lipoate-protein ligase	-	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB,Lip_prot_lig_C
PYH3_k127_8974022_1	592015.HMPREF1705_00650	1.248e-85	295.0	COG2516@1|root,COG2516@2|Bacteria,3TB3Y@508458|Synergistetes	508458|Synergistetes	S	Radical SAM domain protein	-	-	2.8.1.6	ko:K01012	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
PYH3_k127_8974022_7	304371.MCP_1168	2.089e-33	144.0	COG0644@1|root,arCOG00570@2157|Archaea,2XUI9@28890|Euryarchaeota,2N9DD@224756|Methanomicrobia	224756|Methanomicrobia	C	TIGRFAM geranylgeranyl reductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3,HI0933_like,Lycopene_cycl
PYH3_k127_8974022_9	1321814.HMPREF9089_01466	1.952e-06	52.0	COG4739@1|root,COG4739@2|Bacteria,1V3K5@1239|Firmicutes,24INA@186801|Clostridia,25WMY@186806|Eubacteriaceae	186801|Clostridia	S	Uncharacterized protein containing a ferredoxin domain (DUF2148)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2148
PYH3_k127_9128052_3	3218.PP1S9_169V6.1	2.863e-24	105.0	28NEG@1|root,2S3TG@2759|Eukaryota,37W4G@33090|Viridiplantae,3GXEK@35493|Streptophyta	35493|Streptophyta	S	Staygreen protein	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006787,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009536,GO:0009579,GO:0009892,GO:0009894,GO:0009895,GO:0009987,GO:0010271,GO:0015994,GO:0015996,GO:0016020,GO:0019222,GO:0019439,GO:0031323,GO:0031324,GO:0031329,GO:0031330,GO:0031976,GO:0031984,GO:0033013,GO:0033015,GO:0034357,GO:0034641,GO:0042440,GO:0042651,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044248,GO:0044270,GO:0044422,GO:0044424,GO:0044435,GO:0044436,GO:0044444,GO:0044446,GO:0044464,GO:0046149,GO:0046483,GO:0046700,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051186,GO:0051187,GO:0051193,GO:0051195,GO:0055035,GO:0065007,GO:0071704,GO:0090056,GO:1901360,GO:1901361,GO:1901401,GO:1901402,GO:1901404,GO:1901405,GO:1901564,GO:1901565,GO:1901575,GO:1903647	4.99.1.10	ko:K22013	ko00860,ko01110,map00860,map01110	-	R08584,R09033	RC01012	ko00000,ko00001,ko01000	-	-	-	Staygreen
PYH3_k127_9128052_4	1278073.MYSTI_00455	0.0001765	53.0	COG1040@1|root,COG1040@2|Bacteria,1N668@1224|Proteobacteria,430SZ@68525|delta/epsilon subdivisions,2WVMF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	zinc-ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	DZR
PYH3_k127_9128052_2	398512.JQKC01000027_gene3915	3.665e-85	296.0	COG1680@1|root,COG1680@2|Bacteria,1TR9E@1239|Firmicutes,2480P@186801|Clostridia,3WRFA@541000|Ruminococcaceae	186801|Clostridia	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
PYH3_k127_9128052_1	118173.KB235910_gene4790	1.944e-89	309.0	COG4552@1|root,COG4552@2|Bacteria	2|Bacteria	S	transferase activity, transferring acyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_9,SCP2_2
PYH3_k127_9128052_0	1047013.AQSP01000045_gene108	1.218e-140	459.0	COG1748@1|root,COG1748@2|Bacteria,2NNZ1@2323|unclassified Bacteria	2|Bacteria	E	Saccharopine dehydrogenase C-terminal domain	lys2	-	1.5.1.10	ko:K00293	ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230	M00030,M00032	R02315	RC00215,RC00225	ko00000,ko00001,ko00002,ko01000	-	-	-	ELFV_dehydrog,Sacchrp_dh_C,Sacchrp_dh_NADP
PYH3_k127_9131887_2	56780.SYN_00463	3.467e-48	175.0	COG0500@1|root,COG2226@2|Bacteria,1QU24@1224|Proteobacteria,43BNY@68525|delta/epsilon subdivisions,2X70A@28221|Deltaproteobacteria,2MRB0@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Mycolic acid cyclopropane synthetase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
PYH3_k127_9131887_1	877455.Metbo_2060	6.667e-69	247.0	COG1537@1|root,arCOG01741@2157|Archaea,2XTQ4@28890|Euryarchaeota,23NQY@183925|Methanobacteria	183925|Methanobacteria	J	May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity	pelA	-	-	ko:K06965	ko03015,map03015	-	-	-	ko00000,ko00001	-	-	-	eRF1_1,eRF1_2,eRF1_3
PYH3_k127_9131887_0	426368.MmarC7_0439	1.399e-72	258.0	COG2108@1|root,arCOG00932@2157|Archaea,2XU78@28890|Euryarchaeota,23Q4H@183939|Methanococci	183939|Methanococci	S	PFAM Radical SAM domain protein	-	-	-	ko:K07129	-	-	-	-	ko00000	-	-	-	Fer4_14,Radical_SAM
PYH3_k127_9131887_3	591019.Shell_1582	1.015e-40	155.0	COG2413@1|root,arCOG04066@2157|Archaea,2XQ4I@28889|Crenarchaeota	28889|Crenarchaeota	S	DNA polymerase beta domain protein region	-	-	-	ko:K07073	-	-	-	-	ko00000	-	-	-	NTP_transf_2
PYH3_k127_9174189_5	237368.SCABRO_00439	6.406e-62	227.0	COG1143@1|root,COG1143@2|Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	asrA	-	-	ko:K16950	ko00920,ko01120,map00920,map01120	-	R00858,R10146	RC00065	ko00000,ko00001	-	-	-	Fer4_22
PYH3_k127_9174189_3	1034345.CAEM01000023_gene834	3.49e-85	290.0	COG0543@1|root,COG0543@2|Bacteria,2HXFY@201174|Actinobacteria,4CV8F@84998|Coriobacteriia	84998|Coriobacteriia	C	Oxidoreductase NAD-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
PYH3_k127_9174189_4	880073.Calab_0419	3.713e-63	225.0	COG1941@1|root,COG1941@2|Bacteria	2|Bacteria	C	coenzyme F420 hydrogenase activity	hoxY	-	1.8.98.5	ko:K14128	ko00680,map00680	-	R00019,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	Oxidored_q6
PYH3_k127_9174189_0	237368.SCABRO_02487	5.48e-102	347.0	COG3259@1|root,COG3259@2|Bacteria,2IYS2@203682|Planctomycetes	203682|Planctomycetes	C	Nickel-dependent hydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	NiFeSe_Hases
PYH3_k127_9174189_1	1151117.AJLF01000003_gene644	2.66e-93	324.0	COG0446@1|root,arCOG01069@2157|Archaea,2XT0A@28890|Euryarchaeota,24368@183968|Thermococci	183968|Thermococci	P	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	-	-	1.6.3.3	ko:K17870	-	-	-	-	ko00000,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
PYH3_k127_9174189_2	673860.AciM339_0552	7.327e-88	299.0	COG0258@1|root,arCOG04050@2157|Archaea,2XTJD@28890|Euryarchaeota,3F2GZ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA	fen	-	-	ko:K04799	ko03030,ko03410,ko03450,map03030,map03410,map03450	-	-	-	ko00000,ko00001,ko01000,ko03032,ko03400,ko04147	-	-	-	XPG_I,XPG_N
PYH3_k127_9195863_4	994573.T472_0206750	3.514e-52	191.0	COG0474@1|root,COG0474@2|Bacteria,1TPF5@1239|Firmicutes,247JN@186801|Clostridia,36DDM@31979|Clostridiaceae	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
PYH3_k127_9195863_5	526227.Mesil_1550	3.433e-05	48.0	2DTS8@1|root,33MFX@2|Bacteria,1WKUR@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_9195863_0	1041930.Mtc_1848	2.442e-121	404.0	COG4608@1|root,arCOG00184@2157|Archaea,2Y5BH@28890|Euryarchaeota,2N9H8@224756|Methanomicrobia	224756|Methanomicrobia	E	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	iAF692.Mbar_A0472	ABC_tran,oligo_HPY
PYH3_k127_9195863_2	1041930.Mtc_1847	1.201e-104	354.0	COG0444@1|root,arCOG00181@2157|Archaea,2XSTM@28890|Euryarchaeota,2NAHK@224756|Methanomicrobia	224756|Methanomicrobia	E	oligopeptide dipeptide ABC transporter	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
PYH3_k127_9195863_3	351160.LRC379	8.775e-95	325.0	COG1173@1|root,arCOG00748@2157|Archaea,2XUIX@28890|Euryarchaeota,2N9GM@224756|Methanomicrobia	224756|Methanomicrobia	P	N-terminal TM domain of oligopeptide transport permease C	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
PYH3_k127_9195863_1	351160.LRC378	1.474e-108	361.0	COG0601@1|root,arCOG00751@2157|Archaea,2XTRU@28890|Euryarchaeota,2NAQG@224756|Methanomicrobia	224756|Methanomicrobia	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
PYH3_k127_9223950_2	994573.T472_0218755	8.327e-35	146.0	28PJ3@1|root,2ZC8W@2|Bacteria,1V220@1239|Firmicutes,24IPD@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_9223950_1	643562.Daes_0683	4.642e-42	166.0	COG1834@1|root,COG1834@2|Bacteria,1MZ9U@1224|Proteobacteria,42PPN@68525|delta/epsilon subdivisions,2WK8S@28221|Deltaproteobacteria,2M7WI@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	PFAM amidinotransferase	-	-	3.5.3.18	ko:K01482	-	-	-	-	ko00000,ko01000,ko04147	-	-	-	Amidinotransf
PYH3_k127_9223950_0	411684.HPDFL43_01695	1.525e-136	445.0	COG0037@1|root,COG0037@2|Bacteria,1NKHX@1224|Proteobacteria,2TVKU@28211|Alphaproteobacteria,43N4M@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	D	ATPase of the PP-loop superfamily implicated in cell cycle control	-	-	-	-	-	-	-	-	-	-	-	-	Asn_synthase,NAD_synthase,PAPS_reduct
PYH3_k127_9264658_0	1365176.N186_08560	9.656e-142	471.0	COG3894@1|root,arCOG02035@2157|Archaea,2XQG9@28889|Crenarchaeota	28889|Crenarchaeota	C	Domain of unknown function (DUF4445)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
PYH3_k127_9264658_1	545694.TREPR_2694	4.205e-81	292.0	2CFN2@1|root,34AP1@2|Bacteria,2JA1Q@203691|Spirochaetes	203691|Spirochaetes	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
PYH3_k127_9272951_0	399550.Smar_1329	8.701e-84	284.0	COG0444@1|root,arCOG00181@2157|Archaea,2XPR3@28889|Crenarchaeota	28889|Crenarchaeota	E	TIGRFAM oligopeptide dipeptide ABC transporter, ATPase subunit	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
PYH3_k127_9272951_2	1499967.BAYZ01000132_gene306	4.48e-63	242.0	COG1173@1|root,COG1173@2|Bacteria	2|Bacteria	P	ABC-type dipeptide oligopeptide nickel transport systems, permease components	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
PYH3_k127_9272951_1	1304874.JAFY01000002_gene135	4.159e-74	261.0	COG0601@1|root,COG0601@2|Bacteria,3TAG1@508458|Synergistetes	508458|Synergistetes	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
PYH3_k127_9272951_3	1229909.NSED_03330	5.018e-34	137.0	COG1280@1|root,arCOG01947@2157|Archaea,41T36@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Lysine exporter protein LysE YggA	-	-	-	-	-	-	-	-	-	-	-	-	LysE
PYH3_k127_9286202_0	1220534.B655_1867	5.389e-78	269.0	COG0464@1|root,arCOG01308@2157|Archaea,2XSYR@28890|Euryarchaeota,23NT2@183925|Methanobacteria	183925|Methanobacteria	O	Cell division protein 48, CDC48, domain 2	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N
PYH3_k127_9286202_2	1121481.AUAS01000008_gene2946	3.312e-13	75.0	COG1695@1|root,COG1695@2|Bacteria,4NSI4@976|Bacteroidetes,47Q8F@768503|Cytophagia	976|Bacteroidetes	K	Transcriptional regulator	-	-	-	ko:K10947	-	-	-	-	ko00000,ko03000	-	-	-	PadR
PYH3_k127_9286202_1	304371.MCP_0918	8.315e-52	190.0	COG1573@1|root,arCOG00905@2157|Archaea,2XUVI@28890|Euryarchaeota,2N9TK@224756|Methanomicrobia	224756|Methanomicrobia	L	Uracil DNA glycosylase superfamily	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
PYH3_k127_9343167_2	1261545.MBE-HAL_2288	3.834e-11	74.0	COG2309@1|root,arCOG01890@2157|Archaea,2XW76@28890|Euryarchaeota,23V18@183963|Halobacteria	183963|Halobacteria	E	Thermophilic metalloprotease (M29)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M29
PYH3_k127_9343167_0	29176.XP_003884784.1	1.728e-36	151.0	KOG0084@1|root,KOG0084@2759|Eukaryota,3Y9SJ@5794|Apicomplexa,3YJGF@5796|Coccidia,3YUES@5809|Sarcocystidae	5794|Apicomplexa	U	Signal recognition particle receptor beta subunit	rab1	-	-	ko:K07874	ko05134,map05134	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	Ras
PYH3_k127_9343167_3	1206720.BAFQ01000062_gene1621	2.136e-05	52.0	COG4325@1|root,COG4325@2|Bacteria,2IK41@201174|Actinobacteria,4G28Z@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_9343167_1	876269.ARWA01000001_gene2361	3.854e-21	102.0	COG4689@1|root,COG4689@2|Bacteria,1N4IP@1224|Proteobacteria,2TTZX@28211|Alphaproteobacteria,3NA5H@45404|Beijerinckiaceae	28211|Alphaproteobacteria	Q	Acetoacetate decarboxylase (ADC)	adc	-	4.1.1.4	ko:K01574	ko00072,ko00640,ko01100,map00072,map00640,map01100	M00088	R01366	RC00040	ko00000,ko00001,ko00002,ko01000	-	-	-	ADC
PYH3_k127_9393753_1	1227352.C173_19376	3.124e-33	134.0	COG0454@1|root,COG0456@2|Bacteria,1VHPQ@1239|Firmicutes,4HM3W@91061|Bacilli,26XQB@186822|Paenibacillaceae	91061|Bacilli	K	Acetyltransferase (GNAT) family	yrkN3	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_7
PYH3_k127_9393753_0	1183438.GKIL_3603	5.238e-59	220.0	COG3594@1|root,COG3594@2|Bacteria	2|Bacteria	G	nodulation	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
PYH3_k127_9393753_2	272557.APE_2512	5.688e-15	83.0	COG0842@1|root,arCOG01465@2157|Archaea,2XQB0@28889|Crenarchaeota	28889|Crenarchaeota	V	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
PYH3_k127_9458650_11	1041930.Mtc_0784	3.327e-20	99.0	COG0467@1|root,COG2018@1|root,COG2229@1|root,arCOG00362@2157|Archaea,arCOG01171@2157|Archaea,arCOG02603@2157|Archaea,2XXH5@28890|Euryarchaeota,2NB6W@224756|Methanomicrobia	224756|Methanomicrobia	T	ADP-ribosylation factor family	-	-	-	ko:K06945	-	-	-	-	ko00000	-	-	-	ATPase,Arf,Robl_LC7
PYH3_k127_9458650_8	386456.JQKN01000001_gene2095	4.039e-69	246.0	COG1646@1|root,arCOG01085@2157|Archaea,2XTEC@28890|Euryarchaeota,23NWS@183925|Methanobacteria	183925|Methanobacteria	H	Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids	-	-	2.5.1.41	ko:K17104	ko00564,map00564	-	R04158	RC01091	ko00000,ko00001,ko01000	-	-	-	PcrB
PYH3_k127_9458650_12	926567.TheveDRAFT_1333	3.122e-15	78.0	COG1977@1|root,COG1977@2|Bacteria,3TBJI@508458|Synergistetes	508458|Synergistetes	H	TIGRFAM MoaD family protein	-	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
PYH3_k127_9458650_5	399550.Smar_0238	1.935e-117	390.0	COG0167@1|root,COG1143@1|root,arCOG00603@2157|Archaea,arCOG01543@2157|Archaea,2XQ06@28889|Crenarchaeota	28889|Crenarchaeota	C	TIGRFAM dihydroorotate dehydrogenase family protein	-	-	1.3.1.1	ko:K17723	ko00240,ko00410,ko00770,ko01100,map00240,map00410,map00770,map01100	M00046	R00977,R01414,R11026	RC00072,RC00123	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh,Fer4,Fer4_21
PYH3_k127_9458650_2	574087.Acear_1487	8.463e-144	480.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,3WBG8@53433|Halanaerobiales	186801|Clostridia	C	PFAM Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738,ko:K19515	ko00030,ko00362,ko01100,ko01120,ko01200,map00030,map00362,map01100,map01120,map01200	M00309,M00541	R08571,R10961	RC00242,RC01839	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
PYH3_k127_9458650_10	264732.Moth_0721	1.149e-40	156.0	COG1142@1|root,COG1142@2|Bacteria,1UHYS@1239|Firmicutes,24JZC@186801|Clostridia,42H3B@68295|Thermoanaerobacterales	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_11,Fer4_3,Fer4_4,Fer4_6,Fer4_9
PYH3_k127_9458650_3	399550.Smar_0236	5.643e-132	434.0	COG0402@1|root,arCOG00695@2157|Archaea,2XPV1@28889|Crenarchaeota	28889|Crenarchaeota	F	PFAM amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
PYH3_k127_9458650_13	386456.JQKN01000001_gene2197	2.113e-12	72.0	COG1977@1|root,arCOG00536@2157|Archaea	2157|Archaea	H	Molybdopterin converting factor, small subunit	-	-	2.7.7.80	ko:K03636,ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF,ThiS
PYH3_k127_9458650_1	485913.Krac_6352	1.011e-168	542.0	COG0402@1|root,COG0402@2|Bacteria,2G6DG@200795|Chloroflexi	200795|Chloroflexi	F	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine	mtaD	-	3.5.4.28,3.5.4.31	ko:K12960	ko00270,ko01100,map00270,map01100	-	R09660	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1,CYTH
PYH3_k127_9458650_6	490899.DKAM_0117	8.495e-105	351.0	COG0448@1|root,arCOG00912@2157|Archaea,2XPXX@28889|Crenarchaeota	28889|Crenarchaeota	E	PFAM aspartate ornithine carbamoyltransferase, Asp Orn-binding region	-	-	-	-	-	-	-	-	-	-	-	-	OTCace,OTCace_N
PYH3_k127_9458650_7	490899.DKAM_0230	5.26e-98	331.0	COG0448@1|root,arCOG00912@2157|Archaea,2XQ4D@28889|Crenarchaeota	28889|Crenarchaeota	E	aspartate ornithine carbamoyltransferase, carbamoyl-P binding domain	-	-	-	-	-	-	-	-	-	-	-	-	OTCace,OTCace_N
PYH3_k127_9458650_9	1392502.JNIO01000008_gene2927	6.859e-46	175.0	COG0084@1|root,COG0084@2|Bacteria,1TNY1@1239|Firmicutes,4H2S5@909932|Negativicutes	909932|Negativicutes	L	hydrolase, TatD family	ycfH	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
PYH3_k127_9458650_0	688269.Theth_1455	2.887e-169	551.0	COG0449@1|root,COG0449@2|Bacteria,2GBY1@200918|Thermotogae	200918|Thermotogae	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	-	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	SIS
PYH3_k127_9458650_4	633148.Tagg_0552	1.605e-125	414.0	COG0498@1|root,arCOG01434@2157|Archaea,2XQ1A@28889|Crenarchaeota	28889|Crenarchaeota	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
PYH3_k127_945919_1	1123373.ATXI01000008_gene1576	3.454e-15	85.0	COG1801@1|root,COG1801@2|Bacteria,2GH84@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
PYH3_k127_945919_0	572479.Hprae_0499	8.204e-71	255.0	COG2407@1|root,COG2407@2|Bacteria,1TPEK@1239|Firmicutes,24BY2@186801|Clostridia	186801|Clostridia	G	Converts the aldose L-fucose into the corresponding ketose L-fuculose	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_9468487_6	1267535.KB906767_gene509	4.746e-17	84.0	COG1308@1|root,COG1308@2|Bacteria,3Y60R@57723|Acidobacteria	57723|Acidobacteria	K	Domain of unknown function (DUF4342)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4342
PYH3_k127_9468487_4	304371.MCP_1481	1.408e-26	121.0	28M2T@1|root,2N55N@2157|Archaea,2Y31V@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_9468487_1	760568.Desku_0702	4.248e-66	235.0	COG1122@1|root,COG1122@2|Bacteria,1TPH8@1239|Firmicutes,248A2@186801|Clostridia,2611M@186807|Peptococcaceae	186801|Clostridia	P	Part of an ABC transporter complex. Responsible for energy coupling to the transport system	-	-	-	ko:K02006	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	ABC_tran
PYH3_k127_9468487_3	1089553.Tph_c09780	3.15e-28	124.0	COG0619@1|root,COG0619@2|Bacteria,1U6XW@1239|Firmicutes,24EV0@186801|Clostridia,42GS9@68295|Thermoanaerobacterales	186801|Clostridia	P	Cobalt ABC transporter	cbiQ	-	-	ko:K02008	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiQ
PYH3_k127_9468487_2	387631.Asulf_01880	6.896e-45	173.0	COG0310@1|root,arCOG02248@2157|Archaea,2XU97@28890|Euryarchaeota,2462C@183980|Archaeoglobi	183980|Archaeoglobi	P	Cobalamin (Vitamin B12) biosynthesis CbiM protein	-	-	-	ko:K02007	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiM
PYH3_k127_9468487_5	1094980.Mpsy_2015	2.29e-25	112.0	COG0864@1|root,arCOG01008@2157|Archaea,2XWHW@28890|Euryarchaeota,2N9KS@224756|Methanomicrobia	224756|Methanomicrobia	K	Transcriptional regulator	-	-	-	ko:K07722	-	-	-	-	ko00000,ko03000	-	-	-	NikR_C,RHH_1
PYH3_k127_9468487_0	1499967.BAYZ01000013_gene6439	1.005e-66	233.0	COG1331@1|root,COG1331@2|Bacteria,2NP26@2323|unclassified Bacteria	2|Bacteria	O	Protein of unknown function, DUF255	yyaL	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	DsbC,GlcNAc_2-epim,Thioredox_DsbH
PYH3_k127_9565765_1	391625.PPSIR1_35652	2.946e-62	235.0	COG0433@1|root,COG0433@2|Bacteria,1R7B1@1224|Proteobacteria,42NW4@68525|delta/epsilon subdivisions,2X6WX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	AAA-like domain	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_9565765_3	767029.HMPREF9154_2509	0.0003476	48.0	COG2018@1|root,COG2018@2|Bacteria	2|Bacteria	K	Roadblock/LC7 domain	-	-	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
PYH3_k127_9565765_2	357808.RoseRS_3311	2.627e-18	92.0	COG1896@1|root,COG1896@2|Bacteria,2G72G@200795|Chloroflexi,3778D@32061|Chloroflexia	32061|Chloroflexia	S	PFAM metal-dependent phosphohydrolase, HD sub domain	-	-	-	ko:K07023	-	-	-	-	ko00000	-	-	-	HD_3
PYH3_k127_9565765_0	1151117.AJLF01000001_gene885	2.12e-77	272.0	COG0017@1|root,arCOG00406@2157|Archaea,2XTRE@28890|Euryarchaeota,242Q1@183968|Thermococci	183968|Thermococci	J	Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp)	aspS	-	6.1.1.12	ko:K22503	ko00970,map00970	M00359	R05577	RC00055,RC00523	ko00000,ko00001,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
PYH3_k127_9586799_2	572478.Vdis_2239	4.21e-64	234.0	COG0470@1|root,arCOG00470@2157|Archaea,2XPN9@28889|Crenarchaeota	28889|Crenarchaeota	L	Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA	rfcL	-	-	ko:K04800	ko03030,map03030	-	-	-	ko00000,ko00001,ko03032	-	-	-	AAA,RFC1,Rad17
PYH3_k127_9586799_5	666510.ASAC_1325	5.186e-08	58.0	COG0640@1|root,arCOG04056@2157|Archaea,2XR0A@28889|Crenarchaeota	28889|Crenarchaeota	K	regulatory protein, arsR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5
PYH3_k127_9586799_1	415426.Hbut_0909	1.371e-81	286.0	COG1474@1|root,arCOG00467@2157|Archaea,2XPZB@28889|Crenarchaeota	28889|Crenarchaeota	L	Involved in regulation of DNA replication	cdc6-2	-	-	ko:K10725	-	-	-	-	ko00000,ko03032	-	-	-	AAA_22,Cdc6_C
PYH3_k127_9586799_6	6334.EFV56580	8.333e-05	51.0	KOG3356@1|root,KOG3356@2759|Eukaryota,38ESS@33154|Opisthokonta,3BIB7@33208|Metazoa,3D02M@33213|Bilateria,40DZ8@6231|Nematoda	33208|Metazoa	S	OST3 / OST6 family, transporter family	OSTC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005789,GO:0006464,GO:0006486,GO:0006487,GO:0006807,GO:0008150,GO:0008152,GO:0008250,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009987,GO:0012505,GO:0016020,GO:0018193,GO:0018196,GO:0018279,GO:0019538,GO:0031984,GO:0032991,GO:0034645,GO:0036211,GO:0042175,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0070085,GO:0071704,GO:0098796,GO:0098827,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1902494,GO:1990234	-	-	-	-	-	-	-	-	-	-	OST3_OST6
PYH3_k127_9586799_3	1104324.P186_2173	2.202e-30	128.0	COG0575@1|root,arCOG04106@2157|Archaea,2XQTI@28889|Crenarchaeota	28889|Crenarchaeota	I	Catalyzes the formation of CDP-2,3-bis-(O- geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O- geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids	carS	-	2.7.7.67	ko:K19664	ko00564,map00564	-	R08966	RC00002	ko00000,ko00001,ko01000	-	-	-	CarS-like
PYH3_k127_9586799_4	267377.MMP0617	7.82e-27	121.0	COG0468@1|root,arCOG00417@2157|Archaea,2XTI2@28890|Euryarchaeota,23Q38@183939|Methanococci	183939|Methanococci	L	Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange	radB	GO:0000150,GO:0000217,GO:0000400,GO:0000724,GO:0000725,GO:0000730,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003697,GO:0003824,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006312,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022607,GO:0033554,GO:0034622,GO:0034641,GO:0042148,GO:0042623,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0045003,GO:0046483,GO:0050896,GO:0051716,GO:0065003,GO:0065004,GO:0071704,GO:0071824,GO:0071840,GO:0090304,GO:0090735,GO:0097159,GO:0140097,GO:1901360,GO:1901363	-	ko:K04484	-	-	-	-	ko00000,ko03400	-	-	-	Rad51
PYH3_k127_9586799_0	391623.TERMP_01136	4.194e-124	421.0	COG1199@1|root,arCOG00770@2157|Archaea,2XTH2@28890|Euryarchaeota,243PF@183968|Thermococci	183968|Thermococci	L	HELICc2	-	-	3.6.4.12	ko:K10844	ko03022,ko03420,map03022,map03420	M00290	-	-	ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	DEAD_2,HBB,Helicase_C_2
PYH3_k127_9606829_1	1054217.TALC_01392	2.724e-33	141.0	COG3875@1|root,arCOG02046@2157|Archaea,2XVDD@28890|Euryarchaeota	28890|Euryarchaeota	S	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
PYH3_k127_9606829_2	55529.EKX45972	3.378e-11	70.0	KOG3330@1|root,KOG3330@2759|Eukaryota	2759|Eukaryota	U	Golgi vesicle transport	TRAPPC3	GO:0000139,GO:0002790,GO:0003674,GO:0005085,GO:0005088,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005768,GO:0005793,GO:0005794,GO:0005801,GO:0005829,GO:0006403,GO:0006810,GO:0006886,GO:0006888,GO:0006891,GO:0006900,GO:0006901,GO:0006903,GO:0006996,GO:0007275,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0012505,GO:0015031,GO:0015833,GO:0015931,GO:0016020,GO:0016043,GO:0016050,GO:0016192,GO:0017016,GO:0017112,GO:0017137,GO:0018996,GO:0019899,GO:0022607,GO:0030008,GO:0031090,GO:0031267,GO:0031410,GO:0031982,GO:0031984,GO:0032501,GO:0032502,GO:0032940,GO:0032991,GO:0033036,GO:0033106,GO:0033227,GO:0034613,GO:0035264,GO:0040002,GO:0040007,GO:0042303,GO:0042335,GO:0042338,GO:0042886,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043933,GO:0044085,GO:0044422,GO:0044424,GO:0044431,GO:0044433,GO:0044440,GO:0044444,GO:0044446,GO:0044464,GO:0045184,GO:0046903,GO:0046907,GO:0048193,GO:0048194,GO:0048199,GO:0048207,GO:0048208,GO:0048589,GO:0048856,GO:0050657,GO:0050658,GO:0051020,GO:0051179,GO:0051234,GO:0051236,GO:0051640,GO:0051641,GO:0051648,GO:0051649,GO:0051650,GO:0051656,GO:0061024,GO:0065003,GO:0065007,GO:0065009,GO:0070727,GO:0071702,GO:0071705,GO:0071840,GO:0090114,GO:0097708,GO:0098588,GO:0098772,GO:0098791,GO:0099023,GO:1990070,GO:1990071,GO:1990072	-	ko:K09493,ko:K20302	-	-	-	-	ko00000,ko03036,ko03110,ko04131,ko04147	-	-	-	TRAPP
PYH3_k127_9606829_0	693661.Arcve_1203	3.324e-166	532.0	COG1257@1|root,arCOG04260@2157|Archaea,2XTV9@28890|Euryarchaeota,245ZK@183980|Archaeoglobi	183980|Archaeoglobi	I	Hydroxymethylglutaryl-CoA reductase, degradative	-	-	1.1.1.88	ko:K00054	ko00900,ko01110,ko01130,map00900,map01110,map01130	-	R02081	RC00004,RC00644	ko00000,ko00001,ko01000	-	-	-	HMG-CoA_red
PYH3_k127_9649543_6	1151117.AJLF01000003_gene630	1.299e-70	248.0	COG1709@1|root,arCOG04060@2157|Archaea,2XT58@28890|Euryarchaeota,243MS@183968|Thermococci	183968|Thermococci	K	Helix-turn-helix domain	-	-	-	ko:K07731	-	-	-	-	ko00000,ko03000	-	-	-	HTH_19,HTH_3
PYH3_k127_9649543_9	573063.Metin_0449	1.59e-14	77.0	COG1436@1|root,arCOG04102@2157|Archaea,2XZBY@28890|Euryarchaeota,23R66@183939|Methanococci	183939|Methanococci	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpF	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0008150,GO:0015075,GO:0015399,GO:0015405,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022853,GO:0022857,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0051179,GO:0051234,GO:0055085,GO:0090662,GO:0098660,GO:0099131	-	ko:K02122	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_F
PYH3_k127_9649543_1	868131.MSWAN_1972	4.298e-236	743.0	COG1155@1|root,arCOG00868@2157|Archaea,2XT8I@28890|Euryarchaeota,23NK7@183925|Methanobacteria	183925|Methanobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit	atpA	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
PYH3_k127_9649543_11	572478.Vdis_0819	1.343e-07	63.0	COG0704@1|root,arCOG00318@2157|Archaea,2XQIE@28889|Crenarchaeota	28889|Crenarchaeota	K	Phosphate uptake regulator, PhoU	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin,PhoU
PYH3_k127_9649543_2	70601.3258418	2.181e-196	623.0	COG1156@1|root,arCOG00865@2157|Archaea,2XSYQ@28890|Euryarchaeota,2433N@183968|Thermococci	183968|Thermococci	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit	atpB	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
PYH3_k127_9649543_5	1094980.Mpsy_1814	1.072e-71	250.0	COG1478@1|root,arCOG02714@2157|Archaea,2XXJZ@28890|Euryarchaeota,2N9JQ@224756|Methanomicrobia	224756|Methanomicrobia	H	TIGRFAM F420-dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	F420_ligase
PYH3_k127_9649543_7	289376.THEYE_A0627	3.468e-57	209.0	COG0294@1|root,COG0294@2|Bacteria,3J0NS@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	folP	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
PYH3_k127_9649543_4	401526.TcarDRAFT_2683	8.847e-86	297.0	COG0404@1|root,COG0404@2|Bacteria,1TRKX@1239|Firmicutes,4H2WI@909932|Negativicutes	909932|Negativicutes	E	The glycine cleavage system catalyzes the degradation of glycine	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
PYH3_k127_9649543_10	269797.Mbar_A0407	1.807e-11	69.0	arCOG01207@1|root,arCOG01207@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR
PYH3_k127_9649543_8	339860.Msp_1362	1.852e-37	153.0	COG0528@1|root,arCOG00858@2157|Archaea,2XT3U@28890|Euryarchaeota,23NRI@183925|Methanobacteria	183925|Methanobacteria	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
PYH3_k127_9649543_3	386456.JQKN01000002_gene2748	4.255e-119	400.0	COG1503@1|root,arCOG01742@2157|Archaea,2XSV5@28890|Euryarchaeota,23NWK@183925|Methanobacteria	183925|Methanobacteria	J	Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA	prf1	-	-	ko:K03265	ko03015,map03015	-	-	-	ko00000,ko00001,ko03012,ko03019	-	-	-	eRF1_1,eRF1_2,eRF1_3
PYH3_k127_9649543_0	374847.Kcr_1389	1.355e-272	860.0	COG0525@1|root,arCOG00808@2157|Archaea	2157|Archaea	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF692.Mbar_A1976	Anticodon_1,tRNA-synt_1
PYH3_k127_9662137_0	390874.Tpet_0534	7.324e-23	106.0	COG0778@1|root,COG0778@2|Bacteria,2GDMY@200918|Thermotogae	200918|Thermotogae	C	PFAM Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
PYH3_k127_9662137_2	696369.KI912183_gene1256	1.117e-11	78.0	COG4365@1|root,COG4365@2|Bacteria,1TQ2P@1239|Firmicutes,24DMW@186801|Clostridia,261JK@186807|Peptococcaceae	186801|Clostridia	S	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH	bshC	-	-	ko:K22136	-	-	-	-	ko00000	-	-	-	BshC
PYH3_k127_9662137_1	591019.Shell_1026	4.511e-21	101.0	COG1305@1|root,arCOG02165@2157|Archaea,2XRIK@28889|Crenarchaeota	28889|Crenarchaeota	E	transglutaminase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
PYH3_k127_9685735_0	565033.GACE_1889	1.195e-166	535.0	COG0172@1|root,arCOG00403@2157|Archaea,2XTGA@28890|Euryarchaeota,246SZ@183980|Archaeoglobi	183980|Archaeoglobi	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
PYH3_k127_9685735_7	7668.SPU_028360-tr	5.905e-06	58.0	COG5029@1|root,KOG0366@2759|Eukaryota,38DTQ@33154|Opisthokonta,3BACA@33208|Metazoa,3CS6T@33213|Bilateria	33208|Metazoa	O	Rab geranylgeranyltransferase activity	RABGGTB	GO:0003008,GO:0003674,GO:0003824,GO:0004659,GO:0004661,GO:0004663,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005968,GO:0006464,GO:0006807,GO:0007600,GO:0007601,GO:0008150,GO:0008152,GO:0008270,GO:0008289,GO:0008318,GO:0009987,GO:0010941,GO:0016020,GO:0016043,GO:0016740,GO:0016765,GO:0017016,GO:0017137,GO:0018342,GO:0018344,GO:0019538,GO:0019840,GO:0019899,GO:0022607,GO:0031267,GO:0032501,GO:0032991,GO:0036211,GO:0042981,GO:0043067,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043687,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0046982,GO:0046983,GO:0050789,GO:0050794,GO:0050877,GO:0050953,GO:0051020,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0071944,GO:0097354,GO:0140096,GO:1901564,GO:1902494,GO:1990234	2.5.1.60,3.2.1.52	ko:K05956,ko:K12373	ko00511,ko00513,ko00520,ko00531,ko00603,ko00604,ko01100,ko04142,map00511,map00513,map00520,map00531,map00603,map00604,map01100,map04142	M00079	R00022,R06004,R11316	RC00049	ko00000,ko00001,ko00002,ko01000,ko01006,ko03110,ko04131	-	GH20	-	Prenyltrans
PYH3_k127_9685735_1	374847.Kcr_1054	2.835e-85	293.0	COG0492@1|root,arCOG01296@2157|Archaea	2157|Archaea	C	Thioredoxin reductase	trxB	-	1.8.1.9	ko:K00384,ko:K03387	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_3
PYH3_k127_9685735_2	1094980.Mpsy_0420	1.995e-38	152.0	COG0558@1|root,arCOG00670@2157|Archaea,2XZF4@28890|Euryarchaeota,2NAXZ@224756|Methanomicrobia	224756|Methanomicrobia	I	CDP-alcohol phosphatidyltransferase	-	-	2.7.8.39,2.7.8.5	ko:K00995,ko:K17884	ko00564,ko01100,map00564,map01100	-	R01801,R10464	RC00002,RC00017,RC00078,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
PYH3_k127_9685735_6	1343739.PAP_05770	7.832e-19	91.0	COG1695@1|root,arCOG00001@2157|Archaea,2Y6ET@28890|Euryarchaeota,244B9@183968|Thermococci	183968|Thermococci	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
PYH3_k127_9685735_5	523850.TON_0782	2.306e-22	104.0	COG1901@1|root,arCOG01239@2157|Archaea,2XTSB@28890|Euryarchaeota,242WH@183968|Thermococci	183968|Thermococci	J	Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs	trmY	-	2.1.1.257	ko:K16317	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltrn_RNA_2
PYH3_k127_9685735_4	999630.TUZN_1181	1.114e-23	104.0	COG4830@1|root,arCOG04305@2157|Archaea,2XQSV@28889|Crenarchaeota	28889|Crenarchaeota	J	Ribosomal protein S26e	rps26e	-	-	ko:K02976	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S26e
PYH3_k127_9685735_3	1041930.Mtc_0704	7.714e-26	111.0	COG0441@1|root,arCOG00401@2157|Archaea,2XTFI@28890|Euryarchaeota,2N9FW@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	GO:0002161,GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-Thr_ED,tRNA-synt_2b,tRNA_SAD
PYH3_k127_9703722_0	694429.Pyrfu_0380	3.118e-49	184.0	COG2129@1|root,arCOG01147@2157|Archaea,2XQK4@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM metallophosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Metallophos_2
PYH3_k127_9703722_2	273057.SSO0583	1.816e-32	138.0	COG0382@1|root,arCOG00476@2157|Archaea,2XQXW@28889|Crenarchaeota	28889|Crenarchaeota	H	Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids	-	-	2.5.1.42	ko:K17105	ko00564,map00564	-	R04520	RC01171	ko00000,ko00001,ko01000	-	-	-	UbiA
PYH3_k127_9703722_1	632245.CLP_1589	3.277e-46	169.0	COG0017@1|root,COG0017@2|Bacteria,1TP38@1239|Firmicutes,248XN@186801|Clostridia,36FC0@31979|Clostridiaceae	186801|Clostridia	J	L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp	aspS	-	6.1.1.12,6.1.1.23	ko:K01876,ko:K09759	ko00970,map00970	M00359,M00360	R03647,R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	tRNA-synt_2,tRNA_anti-codon
PYH3_k127_9716143_1	316274.Haur_0075	1.034e-34	149.0	COG1721@1|root,COG1721@2|Bacteria,2G7PU@200795|Chloroflexi,375DS@32061|Chloroflexia	32061|Chloroflexia	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
PYH3_k127_9716143_0	69014.TK1846	9.532e-107	355.0	COG0714@1|root,arCOG00434@2157|Archaea,2XSZU@28890|Euryarchaeota,24353@183968|Thermococci	183968|Thermococci	S	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
PYH3_k127_9716143_2	391623.TERMP_02114	1.17e-10	74.0	arCOG01314@1|root,arCOG01314@2157|Archaea,2XVNC@28890|Euryarchaeota,243S2@183968|Thermococci	183968|Thermococci	S	Domain of unknown function (DUF4350)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4350
PYH3_k127_9716143_3	339860.Msp_0154	4.169e-09	69.0	arCOG02487@1|root,arCOG02488@1|root,arCOG02487@2157|Archaea,arCOG02488@2157|Archaea,2Y7UE@28890|Euryarchaeota,23PA5@183925|Methanobacteria	183925|Methanobacteria	S	Right handed beta helix region	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_5
PYH3_k127_974496_0	572478.Vdis_1284	2.456e-36	148.0	COG0496@1|root,arCOG02303@2157|Archaea,2XR4N@28889|Crenarchaeota	28889|Crenarchaeota	S	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates	surE	-	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	SurE
PYH3_k127_974496_1	415426.Hbut_1240	4.69e-32	133.0	COG0794@1|root,arCOG00068@2157|Archaea,2XQ7R@28889|Crenarchaeota	28889|Crenarchaeota	M	PFAM sugar isomerase (SIS)	hxlB	-	5.3.1.27	ko:K08094	ko00030,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00680,map01100,map01120,map01200,map01230	M00345,M00580	R05339,R09780	RC00377	ko00000,ko00001,ko00002,ko01000	-	-	-	SIS
PYH3_k127_9750549_0	1120973.AQXL01000117_gene342	6.119e-59	215.0	COG0384@1|root,COG0384@2|Bacteria,1V38B@1239|Firmicutes,4IRC7@91061|Bacilli	91061|Bacilli	S	phenazine biosynthesis	-	-	5.3.3.17	ko:K06998	ko00405,ko01130,ko02024,map00405,map01130,map02024	M00835	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	PhzC-PhzF
PYH3_k127_9750549_1	868131.MSWAN_0193	3.914e-32	133.0	COG3371@1|root,arCOG02008@2157|Archaea,2Y0X8@28890|Euryarchaeota	28890|Euryarchaeota	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF998
PYH3_k127_975758_7	1365176.N186_02425	2.935e-06	51.0	arCOG05330@1|root,arCOG05330@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_975758_4	1262915.BN574_01134	1.693e-27	125.0	COG0348@1|root,COG0348@2|Bacteria,1TPHF@1239|Firmicutes,4H43Q@909932|Negativicutes	909932|Negativicutes	C	4Fe-4S binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_5
PYH3_k127_975758_1	1365176.N186_05705	1.213e-89	304.0	COG0330@1|root,arCOG01915@2157|Archaea,2XPQN@28889|Crenarchaeota	28889|Crenarchaeota	O	PFAM band 7 protein	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
PYH3_k127_975758_2	1459636.NTE_01764	1.103e-47	177.0	COG1676@1|root,arCOG01701@2157|Archaea,41SHW@651137|Thaumarchaeota	651137|Thaumarchaeota	L	tRNA intron endonuclease, N-terminal domain	-	-	4.6.1.16	ko:K01170	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_int_endo,tRNA_int_endo_N
PYH3_k127_975758_6	368408.Tpen_0852	2.301e-07	61.0	COG0477@1|root,COG1392@1|root,arCOG00130@2157|Archaea,arCOG02640@2157|Archaea	2157|Archaea	P	Phosphate transport regulator	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	MFS_1,PhoU_div
PYH3_k127_975758_3	634497.HAH_0473	1.572e-34	144.0	COG1968@1|root,arCOG04761@2157|Archaea,2XTYX@28890|Euryarchaeota,23T3H@183963|Halobacteria	183963|Halobacteria	I	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP)	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
PYH3_k127_975758_5	195522.BD01_0037	1.464e-14	76.0	COG2036@1|root,arCOG02144@2157|Archaea,2XZYK@28890|Euryarchaeota,244HP@183968|Thermococci	183968|Thermococci	L	Binds and compact DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils. Increases the resistance of DNA to thermal denaturation	-	-	-	-	-	-	-	-	-	-	-	-	CBFD_NFYB_HMF
PYH3_k127_975758_0	529709.PYCH_11820	9.606e-139	452.0	COG0436@1|root,arCOG01131@2157|Archaea,2XVXM@28890|Euryarchaeota,243JD@183968|Thermococci	183968|Thermococci	E	DegT/DnrJ/EryC1/StrS aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
PYH3_k127_995531_2	529818.AMSG_09282T0	0.0008194	49.0	KOG4659@1|root,KOG4659@2759|Eukaryota	2759|Eukaryota	S	Teneurin transmembrane protein	-	GO:0000003,GO:0000902,GO:0000904,GO:0003006,GO:0003008,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005886,GO:0006928,GO:0006935,GO:0007275,GO:0007276,GO:0007399,GO:0007409,GO:0007411,GO:0007413,GO:0007548,GO:0007588,GO:0008037,GO:0008038,GO:0008045,GO:0008150,GO:0008406,GO:0008584,GO:0008585,GO:0009605,GO:0009653,GO:0009790,GO:0009791,GO:0009792,GO:0009886,GO:0009887,GO:0009987,GO:0010171,GO:0010172,GO:0010927,GO:0016020,GO:0016043,GO:0016477,GO:0019953,GO:0022008,GO:0022414,GO:0022607,GO:0030030,GO:0030154,GO:0030182,GO:0030198,GO:0030421,GO:0031175,GO:0032501,GO:0032502,GO:0032504,GO:0032989,GO:0032990,GO:0035295,GO:0040011,GO:0040032,GO:0040039,GO:0042221,GO:0042330,GO:0043062,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044085,GO:0044424,GO:0044464,GO:0044703,GO:0045137,GO:0046545,GO:0046546,GO:0046660,GO:0046661,GO:0048468,GO:0048513,GO:0048563,GO:0048565,GO:0048569,GO:0048598,GO:0048608,GO:0048609,GO:0048646,GO:0048666,GO:0048667,GO:0048699,GO:0048731,GO:0048812,GO:0048856,GO:0048858,GO:0048869,GO:0048870,GO:0050896,GO:0051179,GO:0051674,GO:0051704,GO:0055123,GO:0060465,GO:0061458,GO:0061564,GO:0070831,GO:0071711,GO:0071840,GO:0071944,GO:0097485,GO:0106030,GO:0120036,GO:0120039,GO:2001197	-	-	-	-	-	-	-	-	-	-	EGF,EGF_2,Tox-GHH
PYH3_k127_995531_0	1123508.JH636439_gene1753	8.664e-204	645.0	COG3119@1|root,COG3119@2|Bacteria,2J2DF@203682|Planctomycetes	203682|Planctomycetes	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
PYH3_k127_995531_1	192952.MM_1893	3.434e-171	546.0	COG0641@1|root,arCOG00945@2157|Archaea,2Y0F7@28890|Euryarchaeota,2NAGD@224756|Methanomicrobia	224756|Methanomicrobia	K	SEC-C motif	-	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SEC-C,SPASM
## 1254 queries scanned
## Total time (seconds): 42.95399332046509
## Rate: 29.19 q/s