## Thu Oct 17 12:49:21 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/Potential_rubisco_autotrophic/PYH3_bin.36.fa -m mmseqs --itype genome -o PYH3_bin.36 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/all_bins_1385/PYH3_bin.36 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
PYH3_k127_100044_6	552811.Dehly_0134	1.138e-81	279.0	COG1526@1|root,COG1526@2|Bacteria,2G74E@200795|Chloroflexi	200795|Chloroflexi	C	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH	fdhD	-	-	ko:K02379	-	-	-	-	ko00000	-	-	-	FdhD-NarQ
PYH3_k127_100044_1	340099.Teth39_0280	3.696e-151	488.0	COG1104@1|root,COG1104@2|Bacteria,1TP21@1239|Firmicutes,24888@186801|Clostridia,42FGX@68295|Thermoanaerobacterales	186801|Clostridia	H	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
PYH3_k127_100044_9	351160.RCIX2315	2.312e-63	224.0	COG1136@1|root,arCOG00922@2157|Archaea,2XUH3@28890|Euryarchaeota,2N9GV@224756|Methanomicrobia	224756|Methanomicrobia	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
PYH3_k127_100044_8	1255043.TVNIR_2757	6.501e-71	254.0	COG4591@1|root,COG4591@2|Bacteria,1R1KM@1224|Proteobacteria,1T554@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
PYH3_k127_100044_11	1232410.KI421421_gene3611	6.669e-48	177.0	COG1971@1|root,COG1971@2|Bacteria,1NWBY@1224|Proteobacteria,42RE2@68525|delta/epsilon subdivisions,2WNEN@28221|Deltaproteobacteria,43THX@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	Probably functions as a manganese efflux pump	mntP	-	-	-	-	-	-	-	-	-	-	-	Mntp
PYH3_k127_100044_12	1449063.JMLS01000023_gene2841	5.091e-32	136.0	COG0561@1|root,COG0561@2|Bacteria,1TQQ4@1239|Firmicutes,4IPKJ@91061|Bacilli,2765K@186822|Paenibacillaceae	91061|Bacilli	S	Sucrose-6F-phosphate phosphohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3
PYH3_k127_100044_0	552811.Dehly_0337	9.07e-219	683.0	COG0050@1|root,COG0050@2|Bacteria,2G5KI@200795|Chloroflexi,34D8U@301297|Dehalococcoidia	301297|Dehalococcoidia	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
PYH3_k127_100044_14	515635.Dtur_1377	2.066e-17	82.0	COG0267@1|root,COG0267@2|Bacteria	2|Bacteria	J	Belongs to the bacterial ribosomal protein bL33 family	rpmG	-	-	ko:K02913	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L33
PYH3_k127_100044_15	311424.DhcVS_867	1.191e-12	70.0	COG0690@1|root,COG0690@2|Bacteria,2G9VX@200795|Chloroflexi,34DH3@301297|Dehalococcoidia	301297|Dehalococcoidia	U	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation	secE	-	-	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecE
PYH3_k127_100044_7	311424.DhcVS_866	2.119e-79	268.0	COG0250@1|root,COG0250@2|Bacteria,2G6A3@200795|Chloroflexi,34CRP@301297|Dehalococcoidia	301297|Dehalococcoidia	K	Participates in transcription elongation, termination and antitermination	nusG	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,NusG
PYH3_k127_100044_10	243164.DET0993	3.917e-58	205.0	COG0080@1|root,COG0080@2|Bacteria,2G6FF@200795|Chloroflexi,34DBF@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rplK	-	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
PYH3_k127_100044_4	552811.Dehly_0342	1.189e-100	332.0	COG0081@1|root,COG0081@2|Bacteria,2G6AW@200795|Chloroflexi,34CNG@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	-	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
PYH3_k127_100044_3	643648.Slip_1237	2.072e-128	425.0	COG1545@1|root,COG3425@1|root,COG1545@2|Bacteria,COG3425@2|Bacteria,1UDNN@1239|Firmicutes,24DF4@186801|Clostridia	186801|Clostridia	I	3-Oxoacyl- acyl-carrier-protein (ACP) synthase III C terminal	-	-	2.3.3.10	ko:K01641	ko00072,ko00280,ko00650,ko00900,ko01100,ko01110,ko01130,map00072,map00280,map00650,map00900,map01100,map01110,map01130	M00088,M00095	R01978	RC00004,RC00503	ko00000,ko00001,ko00002,ko01000	-	-	-	ACP_syn_III_C,DUF35_N,OB_aCoA_assoc
PYH3_k127_100044_2	1120973.AQXL01000133_gene1708	1.017e-143	466.0	COG0183@1|root,COG0183@2|Bacteria,1TT8U@1239|Firmicutes,4HDWF@91061|Bacilli,279X4@186823|Alicyclobacillaceae	91061|Bacilli	I	Thiolase, C-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
PYH3_k127_100044_5	933262.AXAM01000050_gene3497	6.349e-82	284.0	COG1545@1|root,COG3425@1|root,COG1545@2|Bacteria,COG3425@2|Bacteria,1QV6D@1224|Proteobacteria,43DCP@68525|delta/epsilon subdivisions,2X8IQ@28221|Deltaproteobacteria,2MPP9@213118|Desulfobacterales	1224|Proteobacteria	I	Rubredoxin-like zinc ribbon domain (DUF35_N)	-	-	-	-	-	-	-	-	-	-	-	-	ACP_syn_III_C,DUF35_N,OB_aCoA_assoc
PYH3_k127_102008_2	552811.Dehly_0192	3.88e-15	82.0	2BQDV@1|root,32J94@2|Bacteria,2GB0R@200795|Chloroflexi,34DQ2@301297|Dehalococcoidia	301297|Dehalococcoidia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_102008_0	255470.cbdbA873	1.49e-107	359.0	COG2805@1|root,COG2805@2|Bacteria,2GANC@200795|Chloroflexi,34CV8@301297|Dehalococcoidia	301297|Dehalococcoidia	NU	Type II/IV secretion system protein	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
PYH3_k127_102008_4	552811.Dehly_0786	3.697e-12	68.0	COG0789@1|root,COG0789@2|Bacteria	2|Bacteria	K	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding	-	-	2.1.1.37	ko:K00558,ko:K13639,ko:K13640	ko00270,ko01100,ko05206,map00270,map01100,map05206	M00035	R04858	RC00003,RC00332	ko00000,ko00001,ko00002,ko01000,ko02048,ko03000,ko03032,ko03036	-	-	-	DNA_methylase,MerR,MerR_1
PYH3_k127_102008_3	1198452.Jab_2c14460	2.827e-13	76.0	COG2197@1|root,COG2197@2|Bacteria,1MYTT@1224|Proteobacteria,2W909@28216|Betaproteobacteria,47792@75682|Oxalobacteraceae	28216|Betaproteobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
PYH3_k127_102008_1	255470.cbdbA1301	1.353e-64	229.0	COG2197@1|root,COG2197@2|Bacteria,2G6K0@200795|Chloroflexi,34D88@301297|Dehalococcoidia	301297|Dehalococcoidia	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
PYH3_k127_1020347_1	1158165.KB898871_gene2502	1.032e-15	83.0	COG0484@1|root,COG0484@2|Bacteria,1MUZ4@1224|Proteobacteria,1RP09@1236|Gammaproteobacteria,1WX0B@135613|Chromatiales	135613|Chromatiales	O	heat shock protein DnaJ	-	-	-	ko:K05516	-	-	-	-	ko00000,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C
PYH3_k127_1020347_0	439235.Dalk_1142	6.084e-67	246.0	COG1042@1|root,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,42KZW@68525|delta/epsilon subdivisions,2WIQB@28221|Deltaproteobacteria,2MIWX@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM CoA-binding domain protein	-	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
PYH3_k127_1020347_2	1123514.KB905899_gene1379	5.406e-09	57.0	COG0332@1|root,COG0332@2|Bacteria,1MU9N@1224|Proteobacteria,1RNIR@1236|Gammaproteobacteria,45ZQP@72273|Thiotrichales	72273|Thiotrichales	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
PYH3_k127_1074453_1	357808.RoseRS_0315	1.155e-54	216.0	COG1305@1|root,COG1305@2|Bacteria,2G66M@200795|Chloroflexi,37570@32061|Chloroflexia	32061|Chloroflexia	E	PFAM transglutaminase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF4129,Transglut_core
PYH3_k127_1074453_0	1348657.M622_02725	1.81e-69	251.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VN0B@28216|Betaproteobacteria	28216|Betaproteobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
PYH3_k127_1074453_2	1380386.JIAW01000018_gene2885	3.337e-35	141.0	COG1804@1|root,COG1804@2|Bacteria,2GMIW@201174|Actinobacteria,232WV@1762|Mycobacteriaceae	201174|Actinobacteria	C	L-carnitine dehydratase bile acid-inducible protein F	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
PYH3_k127_1162035_3	525368.HMPREF0591_3300	1.818e-45	174.0	COG1735@1|root,COG1735@2|Bacteria,2GMZ6@201174|Actinobacteria,2360H@1762|Mycobacteriaceae	201174|Actinobacteria	S	Phosphotriesterase	php	-	-	ko:K07048	-	-	-	-	ko00000	-	-	-	PTE
PYH3_k127_1162035_1	177437.HRM2_01980	9.501e-77	271.0	COG1902@1|root,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,42NA7@68525|delta/epsilon subdivisions,2WIN5@28221|Deltaproteobacteria,2MJ30@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM NADH flavin oxidoreductase NADH oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN
PYH3_k127_1162035_0	926569.ANT_14850	8.076e-81	281.0	COG2055@1|root,COG2055@2|Bacteria,2G6M2@200795|Chloroflexi	200795|Chloroflexi	C	Malate/L-lactate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Ldh_2
PYH3_k127_1162035_2	96561.Dole_1589	2.458e-74	259.0	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	catD	-	3.1.1.24	ko:K01055	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00568	R02991	RC00825	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1,Abhydrolase_4,Abhydrolase_6
PYH3_k127_1162035_4	469371.Tbis_1962	8.338e-08	58.0	COG1503@1|root,COG1503@2|Bacteria,2IFQH@201174|Actinobacteria,4E2MK@85010|Pseudonocardiales	201174|Actinobacteria	J	translation release factor activity	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_1184936_26	552811.Dehly_1472	2.257e-30	123.0	COG0335@1|root,COG0335@2|Bacteria,2G6W0@200795|Chloroflexi,34DAN@301297|Dehalococcoidia	301297|Dehalococcoidia	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site	rplS	-	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
PYH3_k127_1184936_4	552811.Dehly_1471	1.507e-231	741.0	COG1198@1|root,COG1198@2|Bacteria,2G60J@200795|Chloroflexi,34D0F@301297|Dehalococcoidia	301297|Dehalococcoidia	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Helicase_C,ResIII
PYH3_k127_1184936_24	243164.DET0760	1.741e-48	179.0	COG0242@1|root,COG0242@2|Bacteria,2G6VE@200795|Chloroflexi,34CVZ@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
PYH3_k127_1184936_25	448385.sce0310	3.471e-47	184.0	COG4552@1|root,COG4552@2|Bacteria,1NBTH@1224|Proteobacteria,42W5G@68525|delta/epsilon subdivisions,2WXK2@28221|Deltaproteobacteria,2YW0Z@29|Myxococcales	28221|Deltaproteobacteria	S	Sterol carrier protein domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_9,SCP2_2
PYH3_k127_1184936_14	243164.DET0364	3.537e-96	328.0	COG0793@1|root,COG0793@2|Bacteria,2G6HR@200795|Chloroflexi,34D77@301297|Dehalococcoidia	301297|Dehalococcoidia	M	tail specific protease	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_S41
PYH3_k127_1184936_31	426368.MmarC7_0720	5.566e-07	61.0	arCOG07801@1|root,arCOG07801@2157|Archaea,2Y3H4@28890|Euryarchaeota,23RJZ@183939|Methanococci	183939|Methanococci	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_1184936_7	479434.Sthe_2529	2.285e-144	470.0	COG1473@1|root,COG1473@2|Bacteria,2G7D3@200795|Chloroflexi	200795|Chloroflexi	S	peptidase dimerisation domain protein	-	-	-	ko:K01436	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
PYH3_k127_1184936_1	383372.Rcas_0372	3.893e-296	935.0	COG0474@1|root,COG0474@2|Bacteria,2G5ZS@200795|Chloroflexi,37711@32061|Chloroflexia	32061|Chloroflexia	P	Cation transporter/ATPase, N-terminus	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
PYH3_k127_1184936_9	335543.Sfum_3585	4.781e-136	442.0	COG1883@1|root,COG1883@2|Bacteria,1MV0G@1224|Proteobacteria,42MH1@68525|delta/epsilon subdivisions,2WJD7@28221|Deltaproteobacteria,2MQ5Q@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Na+-transporting oxaloacetate decarboxylase beta subunit	-	-	4.1.1.3	ko:K01572	ko00620,ko01100,map00620,map01100	-	R00217	RC00040	ko00000,ko00001,ko01000,ko02000	3.B.1.1.1	-	-	OAD_beta
PYH3_k127_1184936_17	373903.Hore_16050	1.881e-80	280.0	COG1940@1|root,COG1940@2|Bacteria,1TPKW@1239|Firmicutes,248U9@186801|Clostridia,3WB29@53433|Halanaerobiales	186801|Clostridia	GK	TIGRFAM ROK family protein	glcK	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS10220	ROK
PYH3_k127_1184936_16	552811.Dehly_1064	8.164e-90	307.0	COG2222@1|root,COG2222@2|Bacteria,2G8HU@200795|Chloroflexi,34D2X@301297|Dehalococcoidia	301297|Dehalococcoidia	G	Bacterial phospho-glucose isomerase C-terminal SIS domain	-	-	5.3.1.8,5.3.1.9	ko:K15916	ko00010,ko00030,ko00051,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R01819,R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	bact-PGI_C
PYH3_k127_1184936_3	330214.NIDE1289	5.355e-243	769.0	COG0058@1|root,COG0058@2|Bacteria,3J0W1@40117|Nitrospirae	40117|Nitrospirae	G	Carbohydrate phosphorylase	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
PYH3_k127_1184936_5	767817.Desgi_3384	3.145e-184	599.0	COG1640@1|root,COG1640@2|Bacteria,1W5VQ@1239|Firmicutes,25E46@186801|Clostridia,2610T@186807|Peptococcaceae	186801|Clostridia	G	PFAM glycoside hydrolase family 77	malQ	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
PYH3_k127_1184936_0	1382356.JQMP01000004_gene488	4.615e-314	972.0	COG0296@1|root,COG0296@2|Bacteria,2G5IR@200795|Chloroflexi,27XZS@189775|Thermomicrobia	189775|Thermomicrobia	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
PYH3_k127_1184936_2	264732.Moth_1810	9.569e-267	843.0	COG1449@1|root,COG1449@2|Bacteria,1UVAN@1239|Firmicutes,24B0Y@186801|Clostridia,42HS1@68295|Thermoanaerobacterales	186801|Clostridia	G	Domain of unknown function (DUF3536)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3536,Glyco_hydro_57
PYH3_k127_1184936_15	326427.Cagg_2948	6.166e-93	313.0	COG2120@1|root,COG2120@2|Bacteria,2G6W3@200795|Chloroflexi,375I3@32061|Chloroflexia	32061|Chloroflexia	S	PFAM LmbE family protein	-	-	3.5.1.115	ko:K18455	-	-	-	-	ko00000,ko01000	-	-	-	PIG-L
PYH3_k127_1184936_10	909663.KI867150_gene741	1.295e-134	444.0	COG0297@1|root,COG0297@2|Bacteria,1MUGM@1224|Proteobacteria,42MT8@68525|delta/epsilon subdivisions,2WITI@28221|Deltaproteobacteria,2MQ4P@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	Synthesizes alpha-1,4-glucan chains using ADP-glucose	-	-	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
PYH3_k127_1184936_11	335543.Sfum_3485	8.954e-119	395.0	COG0448@1|root,COG0448@2|Bacteria,1MVTC@1224|Proteobacteria,42NGK@68525|delta/epsilon subdivisions,2WM29@28221|Deltaproteobacteria,2MQBW@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2768	NTP_transferase
PYH3_k127_1184936_13	1163730.FFONT_0227	1.561e-107	365.0	COG1454@1|root,arCOG00984@2157|Archaea,2XQBU@28889|Crenarchaeota	28889|Crenarchaeota	C	Iron-containing alcohol dehydrogenase	-	-	1.1.1.1,1.2.1.10	ko:K00001,ko:K04072	ko00010,ko00071,ko00350,ko00620,ko00625,ko00626,ko00650,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00620,map00625,map00626,map00650,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00228,R00623,R00754,R01172,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00004,RC00050,RC00087,RC00088,RC00099,RC00116,RC00184,RC00649,RC01195,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
PYH3_k127_1184936_6	1163730.FFONT_0226	1.007e-180	584.0	COG2414@1|root,arCOG00706@2157|Archaea,2XQ6E@28889|Crenarchaeota	28889|Crenarchaeota	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
PYH3_k127_1184936_23	909663.KI867150_gene804	2.806e-53	192.0	COG4747@1|root,COG4747@2|Bacteria,1RDCG@1224|Proteobacteria,42RTD@68525|delta/epsilon subdivisions,2WNC2@28221|Deltaproteobacteria,2MRPV@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	ACT domain	-	-	-	-	-	-	-	-	-	-	-	-	ACT
PYH3_k127_1184936_22	909663.KI867150_gene805	1.523e-59	211.0	COG1014@1|root,COG1014@2|Bacteria,1R92Y@1224|Proteobacteria,42QJI@68525|delta/epsilon subdivisions,2WMFZ@28221|Deltaproteobacteria,2MQJG@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	-	-	1.2.7.3	ko:K00177	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
PYH3_k127_1184936_12	644282.Deba_2362	1.956e-113	371.0	COG1013@1|root,COG1013@2|Bacteria,1N0HY@1224|Proteobacteria,42MTM@68525|delta/epsilon subdivisions,2WJS6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM Thiamine pyrophosphate	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
PYH3_k127_1184936_8	644282.Deba_2361	2.876e-139	452.0	COG0674@1|root,COG0674@2|Bacteria,1MWCI@1224|Proteobacteria,42NJY@68525|delta/epsilon subdivisions,2WIW3@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein	-	-	1.2.7.11,1.2.7.3,1.2.7.7	ko:K00174,ko:K00186	ko00010,ko00020,ko00280,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00280,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197,R07160,R08566,R08567	RC00004,RC02742,RC02833,RC02856	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
PYH3_k127_1184936_29	1123376.AUIU01000012_gene1327	5.313e-14	75.0	COG1146@1|root,COG1146@2|Bacteria	2|Bacteria	C	4 iron, 4 sulfur cluster binding	vorD	-	1.2.7.3	ko:K00176	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_21,Fer4_4,Fer4_7
PYH3_k127_1184936_27	526222.Desal_3269	1.151e-27	115.0	COG3695@1|root,COG3695@2|Bacteria,1N7J2@1224|Proteobacteria,42VQ4@68525|delta/epsilon subdivisions,2WS47@28221|Deltaproteobacteria,2MGUU@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	PFAM Methylated-DNA- protein -cysteine	-	-	-	ko:K07443	-	-	-	-	ko00000	-	-	-	DNA_binding_1
PYH3_k127_1184936_28	1151117.AJLF01000001_gene1481	5.599e-24	115.0	COG0477@1|root,arCOG00130@2157|Archaea,2Y8EI@28890|Euryarchaeota,242RF@183968|Thermococci	183968|Thermococci	G	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
PYH3_k127_1184936_18	1172185.KB911532_gene64	4.978e-75	267.0	COG1804@1|root,COG1804@2|Bacteria,2GRB0@201174|Actinobacteria,4FW2K@85025|Nocardiaceae	201174|Actinobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
PYH3_k127_1184936_19	1415166.NONO_c36050	1.145e-74	259.0	COG1024@1|root,COG1024@2|Bacteria,2GJDK@201174|Actinobacteria,4FX4V@85025|Nocardiaceae	201174|Actinobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	5.3.3.18	ko:K15866	ko00360,ko01120,map00360,map01120	-	R09837,R09839	RC00004,RC00326,RC02689,RC03003	ko00000,ko00001,ko01000	-	-	-	ECH_1,SnoaL_2
PYH3_k127_1184936_20	574087.Acear_1850	1.597e-74	267.0	COG0534@1|root,COG0534@2|Bacteria,1TNZN@1239|Firmicutes,247YX@186801|Clostridia,3WAZ5@53433|Halanaerobiales	186801|Clostridia	V	efflux protein, MATE family	-	-	-	-	-	-	-	-	-	-	-	-	MatE
PYH3_k127_1184936_21	1429046.RR21198_4974	4.228e-63	224.0	COG4689@1|root,COG4689@2|Bacteria	2|Bacteria	Q	acetoacetate decarboxylase activity	adc	-	4.1.1.4	ko:K01574	ko00072,ko00640,ko01100,map00072,map00640,map01100	M00088	R01366	RC00040	ko00000,ko00001,ko00002,ko01000	-	-	-	ADC
PYH3_k127_1289490_0	552811.Dehly_0033	2.94e-252	797.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,2G62W@200795|Chloroflexi,34D3Z@301297|Dehalococcoidia	200795|Chloroflexi	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal
PYH3_k127_1289490_1	290397.Adeh_2087	6.905e-80	274.0	COG0437@1|root,COG5557@1|root,COG0437@2|Bacteria,COG5557@2|Bacteria,1MU1B@1224|Proteobacteria,42NS2@68525|delta/epsilon subdivisions,2WMA0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	fdnH	-	-	ko:K00124	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001	-	-	-	Fer4_11,Fer4_4,NrfD
PYH3_k127_1289490_2	1121920.AUAU01000012_gene2648	1.191e-43	164.0	COG5557@1|root,COG5557@2|Bacteria,3Y3RF@57723|Acidobacteria	57723|Acidobacteria	C	Polysulphide reductase, NrfD	-	-	-	-	-	-	-	-	-	-	-	-	NrfD
PYH3_k127_1323555_4	552811.Dehly_1382	5.19e-77	262.0	COG0115@1|root,COG0115@2|Bacteria,2G5PM@200795|Chloroflexi,34CQR@301297|Dehalococcoidia	301297|Dehalococcoidia	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
PYH3_k127_1323555_6	311424.DhcVS_8	1.51e-45	172.0	COG0344@1|root,COG0344@2|Bacteria,2G9EG@200795|Chloroflexi,34D7V@301297|Dehalococcoidia	301297|Dehalococcoidia	I	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP	-	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
PYH3_k127_1323555_7	690850.Desaf_1653	5.361e-44	167.0	COG1047@1|root,COG1047@2|Bacteria,1RD35@1224|Proteobacteria,42MCS@68525|delta/epsilon subdivisions,2WQGI@28221|Deltaproteobacteria,2MBXZ@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	Peptidyl-prolyl cis-trans isomerase	-	-	5.2.1.8	ko:K01802	-	-	-	-	ko00000,ko01000	-	-	-	FKBP_C
PYH3_k127_1323555_8	309801.trd_0848	1.244e-15	80.0	COG0268@1|root,COG0268@2|Bacteria,2G7AK@200795|Chloroflexi,27YPB@189775|Thermomicrobia	189775|Thermomicrobia	J	Binds directly to 16S ribosomal RNA	rpsT	-	-	ko:K02968	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S20p
PYH3_k127_1323555_1	255470.cbdbA5	7.421e-294	919.0	COG0317@1|root,COG0317@2|Bacteria,2G67Y@200795|Chloroflexi,34CRS@301297|Dehalococcoidia	301297|Dehalococcoidia	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
PYH3_k127_1323555_2	243164.DET0006	2.929e-169	541.0	COG0124@1|root,COG0124@2|Bacteria,2G64E@200795|Chloroflexi,34CWB@301297|Dehalococcoidia	301297|Dehalococcoidia	J	histidyl-tRNA aminoacylation	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
PYH3_k127_1323555_0	243164.DET0004	1.457e-299	932.0	COG0187@1|root,COG0187@2|Bacteria,2G67C@200795|Chloroflexi,34D61@301297|Dehalococcoidia	301297|Dehalococcoidia	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
PYH3_k127_1323555_5	243164.DET0003	2.365e-47	178.0	COG1057@1|root,COG1057@2|Bacteria,2G6MY@200795|Chloroflexi,34D3W@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	-	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
PYH3_k127_1323555_3	255470.cbdbA2	3.931e-84	288.0	COG0536@1|root,COG0536@2|Bacteria,2G5ZT@200795|Chloroflexi,34CK2@301297|Dehalococcoidia	301297|Dehalococcoidia	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	DUF1967,GTP1_OBG,MMR_HSR1
PYH3_k127_1326789_9	255470.cbdbA1212	3.811e-144	466.0	COG0263@1|root,COG0263@2|Bacteria,2G67X@200795|Chloroflexi,34CYZ@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate	proB	-	2.7.2.11	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	M00015	R00239	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,PUA
PYH3_k127_1326789_25	311424.DhcVS_321	3.574e-99	331.0	COG0052@1|root,COG0052@2|Bacteria,2G5J2@200795|Chloroflexi,34D52@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Belongs to the universal ribosomal protein uS2 family	rpsB	-	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
PYH3_k127_1326789_34	552811.Dehly_1017	1.853e-61	216.0	COG0264@1|root,COG0264@2|Bacteria,2G6MJ@200795|Chloroflexi,34CST@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	-	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
PYH3_k127_1326789_21	255470.cbdbA319	2.479e-102	337.0	COG0528@1|root,COG0528@2|Bacteria,2G5RG@200795|Chloroflexi,34CMF@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
PYH3_k127_1326789_36	243164.DET0374	1.229e-57	206.0	COG0233@1|root,COG0233@2|Bacteria,2G6FY@200795|Chloroflexi,34CXE@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	-	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
PYH3_k127_1326789_29	243164.DET0373	4.164e-79	271.0	COG0020@1|root,COG0020@2|Bacteria,2G65C@200795|Chloroflexi,34D15@301297|Dehalococcoidia	301297|Dehalococcoidia	H	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
PYH3_k127_1326789_35	552811.Dehly_0199	4.333e-60	218.0	COG4589@1|root,COG4589@2|Bacteria,2G6QV@200795|Chloroflexi,34CIW@301297|Dehalococcoidia	301297|Dehalococcoidia	M	Cytidylyltransferase family	cdsA	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
PYH3_k127_1326789_10	311424.DhcVS_315	6.196e-138	449.0	COG0743@1|root,COG0743@2|Bacteria,2G5RB@200795|Chloroflexi,34CVA@301297|Dehalococcoidia	301297|Dehalococcoidia	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	-	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	-	DXPR_C,DXP_redisom_C,DXP_reductoisom
PYH3_k127_1326789_27	243164.DET0370	2.137e-94	320.0	COG0750@1|root,COG0750@2|Bacteria,2G6HV@200795|Chloroflexi,34D8H@301297|Dehalococcoidia	301297|Dehalococcoidia	M	Domain present in PSD-95, Dlg, and ZO-1/2.	-	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_M50
PYH3_k127_1326789_16	298653.Franean1_6359	1.926e-110	370.0	COG1804@1|root,COG1804@2|Bacteria,2GIU7@201174|Actinobacteria	201174|Actinobacteria	C	L-carnitine dehydratase bile acid-inducible protein F	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
PYH3_k127_1326789_11	1121428.DESHY_80102___1	1.85e-128	420.0	COG0821@1|root,COG0821@2|Bacteria,1TPFR@1239|Firmicutes,247N1@186801|Clostridia,260R0@186807|Peptococcaceae	186801|Clostridia	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	-	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS06430	GcpE
PYH3_k127_1326789_20	1121423.JONT01000005_gene2608	1.778e-105	349.0	COG0384@1|root,COG0384@2|Bacteria,1TPPX@1239|Firmicutes,247ZD@186801|Clostridia	186801|Clostridia	S	Phenazine biosynthesis protein, PhzF family	-	-	5.3.3.17	ko:K06998	ko00405,ko01130,ko02024,map00405,map01130,map02024	M00835	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	PhzC-PhzF
PYH3_k127_1326789_15	311424.DhcVS_834	5.364e-113	374.0	COG1693@1|root,COG1693@2|Bacteria,2GAMC@200795|Chloroflexi,34CRM@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Ribonuclease R winged-helix domain	-	-	-	ko:K09720	-	-	-	-	ko00000,ko03000	-	-	-	DUF128,HTH_12
PYH3_k127_1326789_0	552811.Dehly_0140	3.479e-293	905.0	COG2070@1|root,COG2070@2|Bacteria	2|Bacteria	S	nitronate monooxygenase activity	ycf23	-	1.1.1.205,1.13.12.16	ko:K00088,ko:K00459	ko00230,ko00910,ko00983,ko01100,ko01110,map00230,map00910,map00983,map01100,map01110	M00050	R00025,R01130,R08240	RC00143,RC02207,RC02541,RC02759	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	DUF561,Glu_synthase,IMPDH,NMO
PYH3_k127_1326789_39	177439.DP0684	1.081e-46	173.0	COG1905@1|root,COG1905@2|Bacteria,1RHBU@1224|Proteobacteria,42U8S@68525|delta/epsilon subdivisions,2WQ8V@28221|Deltaproteobacteria,2MKT7@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit	nuoE-1	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
PYH3_k127_1326789_3	632518.Calow_1089	5.461e-222	700.0	COG1894@1|root,COG1894@2|Bacteria,1TQB0@1239|Firmicutes,2483E@186801|Clostridia,42EM7@68295|Thermoanaerobacterales	186801|Clostridia	C	NADH ubiquinone oxidoreductase, F subunit, iron sulphur binding	hymB	-	1.12.1.3,1.17.1.11,1.6.5.3	ko:K00335,ko:K18331,ko:K22339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
PYH3_k127_1326789_38	177439.DP0682	2.224e-51	189.0	COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,42SPZ@68525|delta/epsilon subdivisions,2WIV9@28221|Deltaproteobacteria,2MIGI@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM molybdopterin oxidoreductase	-	-	1.17.1.10,1.17.1.9	ko:K00123,ko:K05299	ko00630,ko00680,ko00720,ko01100,ko01120,ko01200,map00630,map00680,map00720,map01100,map01120,map01200	M00377	R00134,R00519	RC02796	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_4,Fer4,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
PYH3_k127_1326789_18	555088.DealDRAFT_2115	2.183e-106	356.0	COG0579@1|root,COG0579@2|Bacteria,1TRDH@1239|Firmicutes,248IK@186801|Clostridia,42JQ4@68298|Syntrophomonadaceae	186801|Clostridia	C	FAD dependent oxidoreductase	-	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,Fer2_BFD
PYH3_k127_1326789_5	935845.JADQ01000012_gene2726	9.499e-195	624.0	COG0441@1|root,COG0441@2|Bacteria,1TP78@1239|Firmicutes,4HABZ@91061|Bacilli,26QJC@186822|Paenibacillaceae	91061|Bacilli	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
PYH3_k127_1326789_37	552811.Dehly_0823	2.691e-57	205.0	COG0290@1|root,COG0290@2|Bacteria,2G6N2@200795|Chloroflexi,34DC4@301297|Dehalococcoidia	301297|Dehalococcoidia	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	-	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
PYH3_k127_1326789_50	243164.DET0751	4.062e-16	80.0	COG0291@1|root,COG0291@2|Bacteria,2G7D1@200795|Chloroflexi,34DG6@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Belongs to the bacterial ribosomal protein bL35 family	rpmI	-	-	ko:K02916	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35p
PYH3_k127_1326789_41	311424.DhcVS_656	8.38e-38	145.0	COG0292@1|root,COG0292@2|Bacteria,2G6V4@200795|Chloroflexi,34DDX@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	-	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
PYH3_k127_1326789_12	311424.DhcVS_309	3.406e-124	407.0	COG0016@1|root,COG0016@2|Bacteria,2G5T1@200795|Chloroflexi,34CPK@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
PYH3_k127_1326789_1	311424.DhcVS_310	4.381e-229	734.0	COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,2G5QR@200795|Chloroflexi,34CIT@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
PYH3_k127_1326789_47	573061.Clocel_3400	1.808e-22	105.0	COG0500@1|root,COG0789@1|root,COG0789@2|Bacteria,COG2226@2|Bacteria,1UI7M@1239|Firmicutes,24E0D@186801|Clostridia,36N6N@31979|Clostridiaceae	186801|Clostridia	Q	Hypothetical methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
PYH3_k127_1326789_40	933262.AXAM01000004_gene2383	6.038e-44	167.0	COG0613@1|root,COG0613@2|Bacteria,1NFVB@1224|Proteobacteria,43BBY@68525|delta/epsilon subdivisions,2X6R1@28221|Deltaproteobacteria,2MPIB@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF2889)	-	-	3.1.3.97	ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	APH,DUF2889,PHP_C
PYH3_k127_1326789_2	255470.cbdbA310	1.49e-226	714.0	COG0442@1|root,COG0442@2|Bacteria,2G5Q6@200795|Chloroflexi,34CJ8@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
PYH3_k127_1326789_54	350688.Clos_0113	6.241e-07	59.0	COG3340@1|root,COG3340@2|Bacteria,1TRBA@1239|Firmicutes,24HZ5@186801|Clostridia,36KSF@31979|Clostridiaceae	186801|Clostridia	E	Belongs to the peptidase S51 family	pepE	-	3.4.13.21	ko:K05995	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S51
PYH3_k127_1326789_53	525257.HMPREF0204_14916	1.416e-11	77.0	COG1541@1|root,COG1541@2|Bacteria,4NFFT@976|Bacteroidetes,1HZKR@117743|Flavobacteriia,3ZUCH@59732|Chryseobacterium	976|Bacteroidetes	H	COG1541 Coenzyme F390 synthetase	-	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding
PYH3_k127_1326789_14	747365.Thena_0865	4.435e-115	380.0	COG1064@1|root,COG1064@2|Bacteria,1TP5B@1239|Firmicutes,24GKF@186801|Clostridia,42HT2@68295|Thermoanaerobacterales	186801|Clostridia	C	TIGRFAM zinc-binding alcohol dehydrogenase family protein	-	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
PYH3_k127_1326789_7	1047013.AQSP01000126_gene2726	2.424e-167	542.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,2NNR2@2323|unclassified Bacteria	2|Bacteria	G	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	GO:0003674,GO:0003824,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0052855,GO:0052856,GO:0052857	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
PYH3_k127_1326789_49	1104324.P186_2054	2.978e-17	91.0	arCOG03442@1|root,arCOG03442@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_1326789_51	439235.Dalk_4008	2.39e-13	75.0	2CI6U@1|root,33N1H@2|Bacteria,1NQ5J@1224|Proteobacteria,42XMU@68525|delta/epsilon subdivisions,2WSUP@28221|Deltaproteobacteria,2MMAA@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_1326789_44	552811.Dehly_1212	1.362e-30	129.0	COG1238@1|root,COG1238@2|Bacteria,2GARJ@200795|Chloroflexi,34D6F@301297|Dehalococcoidia	301297|Dehalococcoidia	S	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
PYH3_k127_1326789_55	87626.PTD2_04958	1.66e-05	49.0	2DTNT@1|root,33M3P@2|Bacteria,1NH3S@1224|Proteobacteria,1SGZB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_1326789_4	1499967.BAYZ01000035_gene1060	3.594e-201	638.0	COG1032@1|root,COG1032@2|Bacteria,2NQAV@2323|unclassified Bacteria	2|Bacteria	C	Domain of unknown function (DUF4070)	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4070,Radical_SAM
PYH3_k127_1326789_30	311424.DhcVS_31	1.111e-76	261.0	COG1392@1|root,COG1392@2|Bacteria,2G8VT@200795|Chloroflexi,34D5H@301297|Dehalococcoidia	301297|Dehalococcoidia	P	Protein of unknown function DUF47	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
PYH3_k127_1326789_24	1437425.CSEC_0969	2.369e-99	333.0	COG0306@1|root,COG0306@2|Bacteria,2JH20@204428|Chlamydiae	204428|Chlamydiae	P	Phosphate transporter family	-	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
PYH3_k127_1326789_46	255470.cbdbA837	2.253e-26	109.0	2A4FI@1|root,30T1H@2|Bacteria,2GAXA@200795|Chloroflexi,34DIQ@301297|Dehalococcoidia	301297|Dehalococcoidia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_1326789_28	243164.DET0424	2.023e-87	299.0	COG0598@1|root,COG0598@2|Bacteria,2G8D8@200795|Chloroflexi,34D3E@301297|Dehalococcoidia	301297|Dehalococcoidia	P	CorA-like Mg2+ transporter protein	-	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
PYH3_k127_1326789_13	255470.cbdbA1133	7.951e-118	386.0	COG4974@1|root,COG4974@2|Bacteria,2G6CI@200795|Chloroflexi,34D04@301297|Dehalococcoidia	301297|Dehalococcoidia	D	Phage integrase, N-terminal SAM-like domain	xerD	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
PYH3_k127_1326789_32	667014.Thein_1148	7.771e-64	225.0	COG2518@1|root,COG2518@2|Bacteria,2GH2E@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	O	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
PYH3_k127_1326789_19	255470.cbdbA853	8.003e-106	351.0	COG1190@1|root,COG1190@2|Bacteria,2G65Z@200795|Chloroflexi,34D38@301297|Dehalococcoidia	301297|Dehalococcoidia	J	tRNA synthetases class II (D, K and N)	-	-	-	ko:K04568	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	tRNA-synt_2
PYH3_k127_1326789_33	243164.DET0870	7.16e-63	222.0	COG0231@1|root,COG0231@2|Bacteria,2G6PY@200795|Chloroflexi,34D4X@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	-	-	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
PYH3_k127_1326789_31	1321778.HMPREF1982_03131	1.407e-76	270.0	COG0387@1|root,COG0387@2|Bacteria,1TQN2@1239|Firmicutes,248J3@186801|Clostridia	186801|Clostridia	P	calcium proton exchanger	cax	-	-	ko:K07300	-	-	-	-	ko00000,ko02000	2.A.19	-	-	Na_Ca_ex
PYH3_k127_1326789_26	269799.Gmet_2198	4.033e-95	324.0	COG1960@1|root,COG1960@2|Bacteria,1MUBH@1224|Proteobacteria,42S7G@68525|delta/epsilon subdivisions,2WNH7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
PYH3_k127_1326789_17	555793.WSK_3610	1.795e-108	363.0	COG1960@1|root,COG1960@2|Bacteria,1MVJC@1224|Proteobacteria,2TTRD@28211|Alphaproteobacteria,2K4UJ@204457|Sphingomonadales	204457|Sphingomonadales	C	overlaps another CDS with the same product name	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
PYH3_k127_1326789_23	13690.CP98_00468	1.831e-101	343.0	COG1960@1|root,COG1960@2|Bacteria,1P8I7@1224|Proteobacteria,2U0AW@28211|Alphaproteobacteria,2K1N3@204457|Sphingomonadales	204457|Sphingomonadales	C	Acyl-CoA dehydrogenase, middle domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
PYH3_k127_1326789_43	679926.Mpet_0245	5.771e-33	135.0	COG1305@1|root,arCOG02165@2157|Archaea,2Y56U@28890|Euryarchaeota	28890|Euryarchaeota	E	PFAM Transglutaminase-like	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_1326789_45	926561.KB900620_gene3082	8.1e-30	130.0	COG2339@1|root,COG2339@2|Bacteria,1UZGQ@1239|Firmicutes,24D4U@186801|Clostridia,3WBU4@53433|Halanaerobiales	186801|Clostridia	S	Protease prsW family	prsW	-	-	-	-	-	-	-	-	-	-	-	PrsW-protease
PYH3_k127_1326789_48	519989.ECTPHS_07137	9.483e-20	97.0	COG1714@1|root,COG1714@2|Bacteria,1N1XF@1224|Proteobacteria,1SDY3@1236|Gammaproteobacteria,1WZR8@135613|Chromatiales	135613|Chromatiales	S	RDD family	-	-	-	-	-	-	-	-	-	-	-	-	RDD
PYH3_k127_1326789_52	386456.JQKN01000009_gene1205	6.527e-12	69.0	COG1359@1|root,arCOG04806@2157|Archaea,2Y0UN@28890|Euryarchaeota,23P6M@183925|Methanobacteria	183925|Methanobacteria	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
PYH3_k127_1326789_8	1007105.PT7_3036	3.779e-150	491.0	COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2VIYF@28216|Betaproteobacteria,3T5HE@506|Alcaligenaceae	28216|Betaproteobacteria	I	Carboxyl transferase domain	pccB	-	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
PYH3_k127_1326789_42	330214.NIDE4359	9.102e-36	139.0	COG1832@1|root,COG1832@2|Bacteria,3J19F@40117|Nitrospirae	40117|Nitrospirae	S	CoA binding domain	-	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
PYH3_k127_1326789_22	1123376.AUIU01000014_gene584	1.278e-101	338.0	COG1013@1|root,COG1013@2|Bacteria	2|Bacteria	C	oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor	porB	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFO_beta_C,TPP_enzyme_C
PYH3_k127_1326789_6	552811.Dehly_0331	2.935e-176	569.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,2G69H@200795|Chloroflexi	200795|Chloroflexi	C	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
PYH3_k127_1366180_15	368407.Memar_2454	1.935e-14	74.0	COG4802@1|root,arCOG01100@2157|Archaea,2XXWK@28890|Euryarchaeota	28890|Euryarchaeota	C	Ferredoxin thioredoxin reductase catalytic beta chain	-	-	-	-	-	-	-	-	-	-	-	-	FeThRed_B
PYH3_k127_1366180_12	386456.JQKN01000001_gene2350	2.596e-34	133.0	COG4802@1|root,arCOG01100@2157|Archaea,2XXWK@28890|Euryarchaeota	28890|Euryarchaeota	C	Ferredoxin thioredoxin reductase catalytic beta chain	-	-	-	-	-	-	-	-	-	-	-	-	FeThRed_B
PYH3_k127_1366180_13	386456.JQKN01000001_gene2349	1.748e-26	113.0	COG0695@1|root,arCOG02606@2157|Archaea,2Y0MA@28890|Euryarchaeota	28890|Euryarchaeota	O	PFAM glutaredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Glutaredoxin
PYH3_k127_1366180_7	909663.KI867150_gene1508	5.713e-64	230.0	COG1924@1|root,COG1924@2|Bacteria,1R6HU@1224|Proteobacteria,42RWX@68525|delta/epsilon subdivisions,2WNC9@28221|Deltaproteobacteria,2MRP7@213462|Syntrophobacterales	28221|Deltaproteobacteria	I	BadF/BadG/BcrA/BcrD ATPase family	yjiL	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG
PYH3_k127_1366180_3	909663.KI867150_gene1507	1.816e-95	320.0	COG1924@1|root,COG1924@2|Bacteria,1R6HU@1224|Proteobacteria,42RWX@68525|delta/epsilon subdivisions,2WNC9@28221|Deltaproteobacteria,2MRP7@213462|Syntrophobacterales	28221|Deltaproteobacteria	I	BadF/BadG/BcrA/BcrD ATPase family	yjiL	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG
PYH3_k127_1366180_2	909663.KI867150_gene2949	1.663e-98	334.0	COG1775@1|root,COG1775@2|Bacteria,1NNW9@1224|Proteobacteria,42RTN@68525|delta/epsilon subdivisions,2WNYI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	PFAM 2-hydroxyglutaryl-CoA dehydratase, D-component	-	-	-	-	-	-	-	-	-	-	-	-	HGD-D
PYH3_k127_1366180_9	909663.KI867150_gene1506	2.426e-56	214.0	COG1775@1|root,COG1775@2|Bacteria,1NKED@1224|Proteobacteria,42NFZ@68525|delta/epsilon subdivisions,2WMBX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	PFAM 2-hydroxyglutaryl-CoA dehydratase, D-component	-	-	-	-	-	-	-	-	-	-	-	-	HGD-D
PYH3_k127_1366180_5	304371.MCP_0389	1.506e-81	285.0	arCOG11014@1|root,arCOG11014@2157|Archaea,2XZ0A@28890|Euryarchaeota	2157|Archaea	S	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_42
PYH3_k127_1366180_11	768710.DesyoDRAFT_4068	5.352e-38	149.0	28MX3@1|root,2ZB49@2|Bacteria,1V7PT@1239|Firmicutes,25CZN@186801|Clostridia,262I0@186807|Peptococcaceae	186801|Clostridia	S	Protein of unknown function (DUF3795)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3795
PYH3_k127_1366180_6	1217718.ALOU01000047_gene3762	1.358e-66	236.0	COG1024@1|root,COG1024@2|Bacteria,1MWF6@1224|Proteobacteria,2VJSH@28216|Betaproteobacteria,1KGDI@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Enoyl-CoA hydratase/isomerase	echA8_4	-	-	-	-	-	-	-	-	-	-	-	ECH_1
PYH3_k127_1366180_14	1220583.GOACH_33_00300	3.165e-21	102.0	COG0613@1|root,COG1196@1|root,COG0613@2|Bacteria,COG1196@2|Bacteria,2HVUS@201174|Actinobacteria,4GGEZ@85026|Gordoniaceae	201174|Actinobacteria	D	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_23
PYH3_k127_1366180_10	1280664.AUIX01000002_gene525	5.048e-45	171.0	COG0637@1|root,COG0637@2|Bacteria,1V1IW@1239|Firmicutes,24FZZ@186801|Clostridia,4BWIN@830|Butyrivibrio	186801|Clostridia	S	HAD-hyrolase-like	-	-	-	-	-	-	-	-	-	-	-	-	CpXC,HAD_2
PYH3_k127_1366180_0	255470.cbdbA872	2.84e-200	629.0	COG1900@1|root,COG1900@2|Bacteria,2GASV@200795|Chloroflexi,34DA0@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Homocysteine biosynthesis enzyme, sulfur-incorporation	-	-	-	-	-	-	-	-	-	-	-	-	HcyBio
PYH3_k127_1366180_8	311424.DhcVS_791	1.8e-57	202.0	COG1148@1|root,COG1148@2|Bacteria,2GATY@200795|Chloroflexi,34DC8@301297|Dehalococcoidia	301297|Dehalococcoidia	C	NIL	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,NIL
PYH3_k127_1366180_1	368407.Memar_1368	3.192e-107	359.0	COG0205@1|root,arCOG03641@2157|Archaea,2Y33U@28890|Euryarchaeota,2NAA4@224756|Methanomicrobia	224756|Methanomicrobia	G	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfp	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
PYH3_k127_1366180_4	351160.RRC447	2.146e-84	286.0	COG0476@1|root,arCOG01676@2157|Archaea,2XTYV@28890|Euryarchaeota,2N9IZ@224756|Methanomicrobia	224756|Methanomicrobia	H	PFAM UBA THIF-type NAD FAD binding protein	-	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF
PYH3_k127_1376370_0	471852.Tcur_2499	1.624e-90	308.0	COG1960@1|root,COG1960@2|Bacteria,2GJ7S@201174|Actinobacteria,4EQRX@85012|Streptosporangiales	201174|Actinobacteria	C	Acyl-CoA dehydrogenase, middle domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,Thioesterase
PYH3_k127_1376370_2	255470.cbdbA1198	3.544e-17	83.0	COG1522@1|root,COG1522@2|Bacteria,2G7CK@200795|Chloroflexi,34DGT@301297|Dehalococcoidia	301297|Dehalococcoidia	K	Lrp/AsnC ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
PYH3_k127_1376370_1	1121372.AULK01000004_gene1393	1.257e-22	107.0	COG1680@1|root,COG1680@2|Bacteria,2GJJB@201174|Actinobacteria,4FNYJ@85023|Microbacteriaceae	201174|Actinobacteria	V	Beta-lactamase	lipE	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
PYH3_k127_1395842_3	1122176.KB903539_gene1413	1.478e-20	100.0	COG0534@1|root,COG0534@2|Bacteria,4NDUF@976|Bacteroidetes,1IQJT@117747|Sphingobacteriia	976|Bacteroidetes	V	Mate efflux family protein	-	-	-	ko:K03327	-	-	-	-	ko00000,ko02000	2.A.66.1	-	-	MatE
PYH3_k127_1395842_0	1123073.KB899242_gene946	4.501e-250	800.0	COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria,1MVWY@1224|Proteobacteria,1RQ06@1236|Gammaproteobacteria,1X3QM@135614|Xanthomonadales	135614|Xanthomonadales	L	DNA ligase	lig3	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
PYH3_k127_1395842_2	264732.Moth_1489	5.194e-52	193.0	COG1273@1|root,COG1273@2|Bacteria,1TSY5@1239|Firmicutes,249R4@186801|Clostridia,42FJA@68295|Thermoanaerobacterales	186801|Clostridia	L	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD	ku	-	-	ko:K10979	ko03450,map03450	-	-	-	ko00000,ko00001,ko03400	-	-	-	Ku
PYH3_k127_1395842_1	552811.Dehly_0597	4.132e-101	341.0	COG1215@1|root,COG2246@1|root,COG1215@2|Bacteria,COG2246@2|Bacteria,2GBNQ@200795|Chloroflexi	200795|Chloroflexi	M	PFAM Glycosyl transferase family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
PYH3_k127_1395842_4	1380390.JIAT01000009_gene1809	8.877e-19	99.0	COG5650@1|root,COG5650@2|Bacteria,2HYCN@201174|Actinobacteria,4CQKH@84995|Rubrobacteria	84995|Rubrobacteria	S	Glycosyltransferase family 87	-	-	-	-	-	-	-	-	-	-	-	-	GT87
PYH3_k127_1395842_5	69014.TK2188	8.07e-09	67.0	arCOG04615@1|root,arCOG04615@2157|Archaea,2Y2IE@28890|Euryarchaeota,244Z1@183968|Thermococci	183968|Thermococci	S	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
PYH3_k127_1412146_10	243164.DET1200	2.706e-28	117.0	COG0044@1|root,COG0044@2|Bacteria,2G640@200795|Chloroflexi,34CTM@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	pyrC	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
PYH3_k127_1412146_1	243164.DET1201	4.441e-161	514.0	COG0505@1|root,COG0505@2|Bacteria,2G5S1@200795|Chloroflexi,34CMQ@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Carbamoyl-phosphate synthase small chain, CPSase domain	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
PYH3_k127_1412146_0	552811.Dehly_0915	0.0	1624.0	COG0458@1|root,COG0458@2|Bacteria,2G5NX@200795|Chloroflexi,34D66@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Carbamoyl-phosphate synthetase large chain, oligomerisation domain	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
PYH3_k127_1412146_4	243164.DET1203	1.86e-70	246.0	COG0543@1|root,COG0543@2|Bacteria,2G75X@200795|Chloroflexi,34D0J@301297|Dehalococcoidia	301297|Dehalococcoidia	C	Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B	pyrK	-	-	ko:K02823	ko00240,ko01100,map00240,map01100	-	-	-	ko00000,ko00001	-	-	-	DHODB_Fe-S_bind,NAD_binding_1
PYH3_k127_1412146_7	1047013.AQSP01000098_gene2561	1.288e-48	177.0	COG0432@1|root,COG0432@2|Bacteria,2NPR7@2323|unclassified Bacteria	2|Bacteria	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
PYH3_k127_1412146_9	306281.AJLK01000025_gene1720	1.442e-28	125.0	COG2267@1|root,COG2267@2|Bacteria,1G4F2@1117|Cyanobacteria,1JHUI@1189|Stigonemataceae	1117|Cyanobacteria	I	TAP-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4
PYH3_k127_1412146_8	1041147.AUFB01000013_gene80	3.602e-33	139.0	COG1028@1|root,COG1028@2|Bacteria,1MU3W@1224|Proteobacteria,2TSPS@28211|Alphaproteobacteria,4BNBS@82115|Rhizobiaceae	28211|Alphaproteobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
PYH3_k127_1412146_2	311424.DhcVS_1005	3.013e-87	299.0	COG0179@1|root,COG0179@2|Bacteria,2G6H8@200795|Chloroflexi,34CUQ@301297|Dehalococcoidia	301297|Dehalococcoidia	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	DUF2437,FAA_hydrolase
PYH3_k127_1412146_5	1283283.ATXA01000001_gene1287	8.49e-52	199.0	COG1960@1|root,COG1960@2|Bacteria,2H2HU@201174|Actinobacteria	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, middle domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_M,Acyl-CoA_dh_N
PYH3_k127_1412146_3	269799.Gmet_2198	6.988e-86	299.0	COG1960@1|root,COG1960@2|Bacteria,1MUBH@1224|Proteobacteria,42S7G@68525|delta/epsilon subdivisions,2WNH7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
PYH3_k127_1412146_11	1122216.AUHW01000004_gene1629	5.37e-20	93.0	COG0681@1|root,COG0681@2|Bacteria,1V7H9@1239|Firmicutes,4H2Z3@909932|Negativicutes	909932|Negativicutes	U	Belongs to the peptidase S26 family	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
PYH3_k127_1516928_2	311424.DhcVS_793	2.244e-17	85.0	COG2805@1|root,COG2805@2|Bacteria,2GANC@200795|Chloroflexi,34CV8@301297|Dehalococcoidia	301297|Dehalococcoidia	NU	Type II/IV secretion system protein	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
PYH3_k127_1516928_1	243164.DET0130	4.435e-31	125.0	COG0745@1|root,COG0745@2|Bacteria,2GAUB@200795|Chloroflexi,34DD8@301297|Dehalococcoidia	301297|Dehalococcoidia	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
PYH3_k127_1516928_3	479434.Sthe_2339	1.017e-14	76.0	COG1278@1|root,COG1278@2|Bacteria,2G79W@200795|Chloroflexi,27YHA@189775|Thermomicrobia	189775|Thermomicrobia	K	Probable zinc-ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	zf-trcl
PYH3_k127_1516928_0	247490.KSU1_D0177	2.932e-144	464.0	COG0513@1|root,COG0513@2|Bacteria,2IX18@203682|Planctomycetes	203682|Planctomycetes	L	COG0513 Superfamily II DNA and RNA	-	-	3.6.4.13	ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DEAD,Helicase_C
PYH3_k127_15177_10	1197906.CAJQ02000044_gene1672	8.056e-27	110.0	COG2963@1|root,COG2963@2|Bacteria,1MZ3D@1224|Proteobacteria,2UBQE@28211|Alphaproteobacteria,3JZP1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Transposase	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
PYH3_k127_15177_3	1121459.AQXE01000002_gene1213	1.283e-92	312.0	COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,42T3Y@68525|delta/epsilon subdivisions,2WU62@28221|Deltaproteobacteria,2MBJD@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	PFAM Integrase catalytic region	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
PYH3_k127_15177_13	313596.RB2501_04755	2.69e-09	69.0	COG2010@1|root,COG2010@2|Bacteria,4NRFW@976|Bacteroidetes,1I3K8@117743|Flavobacteriia	976|Bacteroidetes	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
PYH3_k127_15177_2	1379698.RBG1_1C00001G0857	2.955e-116	389.0	COG5557@1|root,COG5557@2|Bacteria,2NNNQ@2323|unclassified Bacteria	1379698.RBG1_1C00001G0857|-	C	Polysulphide reductase, NrfD	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_15177_7	1121875.KB907546_gene2674	1.691e-53	201.0	COG0437@1|root,COG0437@2|Bacteria,4NI8R@976|Bacteroidetes,1I01K@117743|Flavobacteriia	976|Bacteroidetes	C	4Fe-4S dicluster domain	-	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_11
PYH3_k127_15177_4	1382356.JQMP01000004_gene282	2.828e-76	264.0	COG0330@1|root,COG0330@2|Bacteria,2G5SB@200795|Chloroflexi,27XRQ@189775|Thermomicrobia	189775|Thermomicrobia	O	prohibitin homologues	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
PYH3_k127_15177_14	1232437.KL661978_gene3792	4.448e-07	58.0	COG0664@1|root,COG0664@2|Bacteria,1NAYS@1224|Proteobacteria,42W1E@68525|delta/epsilon subdivisions,2WS96@28221|Deltaproteobacteria,2MMFZ@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
PYH3_k127_15177_16	1384054.N790_04680	7.607e-05	53.0	COG2197@1|root,COG2197@2|Bacteria,1R9GN@1224|Proteobacteria,1SYQY@1236|Gammaproteobacteria,1X61F@135614|Xanthomonadales	135614|Xanthomonadales	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
PYH3_k127_15177_5	644966.Tmar_1372	1.726e-62	222.0	COG2197@1|root,COG2197@2|Bacteria,1TQ1U@1239|Firmicutes,25B1X@186801|Clostridia,3WDTH@538999|Clostridiales incertae sedis	186801|Clostridia	K	helix_turn_helix, Lux Regulon	-	-	-	ko:K11618	ko02020,map02020	M00481,M00754	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
PYH3_k127_15177_6	871963.Desdi_0959	7.797e-55	217.0	COG2203@1|root,COG4585@1|root,COG5000@1|root,COG2203@2|Bacteria,COG4585@2|Bacteria,COG5000@2|Bacteria,1TR88@1239|Firmicutes,250AK@186801|Clostridia,264XI@186807|Peptococcaceae	186801|Clostridia	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HAMP,HATPase_c,HisKA_3,PAS_9
PYH3_k127_15177_12	1120998.AUFC01000011_gene2574	1.791e-16	94.0	COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia	186801|Clostridia	NT	methyl-accepting chemotaxis protein	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal,dCache_1,sCache_2,sCache_3_3
PYH3_k127_15177_11	1223523.H340_26696	5.39e-19	94.0	COG1309@1|root,COG1309@2|Bacteria,2II5K@201174|Actinobacteria	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_6,TetR_N
PYH3_k127_15177_1	981383.AEWH01000003_gene1528	5.971e-147	478.0	COG0439@1|root,COG0439@2|Bacteria,1TP16@1239|Firmicutes,4HARK@91061|Bacilli	91061|Bacilli	I	An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism	accC	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
PYH3_k127_15177_8	47716.JOFH01000006_gene1797	4.223e-37	147.0	COG2306@1|root,COG2306@2|Bacteria,2GJP9@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF402)	-	-	-	ko:K09145	-	-	-	-	ko00000	-	-	-	DUF402
PYH3_k127_15177_15	255470.cbdbA973	6.39e-05	48.0	COG0477@1|root,COG2814@2|Bacteria,2G9WN@200795|Chloroflexi,34DKS@301297|Dehalococcoidia	301297|Dehalococcoidia	EGP	LacY proton/sugar symporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
PYH3_k127_15177_0	204669.Acid345_3443	1.617e-167	542.0	COG1574@1|root,COG1574@2|Bacteria,3Y2UF@57723|Acidobacteria,2JIRH@204432|Acidobacteriia	204432|Acidobacteriia	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
PYH3_k127_15177_9	243164.DET1621	5.671e-34	147.0	COG3266@1|root,COG3266@2|Bacteria,2G9UR@200795|Chloroflexi,34D8D@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Listeria-Bacteroides repeat domain (List_Bact_rpt)	-	-	-	-	-	-	-	-	-	-	-	-	Flg_new
PYH3_k127_1580423_1	255470.cbdbA29	2.577e-166	550.0	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,2G6G7@200795|Chloroflexi,34CYA@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Domain of unknown function (DUF4131)	-	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
PYH3_k127_1580423_5	243164.DET0025	1.023e-26	116.0	COG1555@1|root,COG1555@2|Bacteria,2G9V3@200795|Chloroflexi,34DAW@301297|Dehalococcoidia	301297|Dehalococcoidia	L	Helix-hairpin-helix motif	-	-	-	ko:K02237	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	HHH_3
PYH3_k127_1580423_2	255470.cbdbA1344	1.062e-83	286.0	COG0266@1|root,COG0266@2|Bacteria,2G6BB@200795|Chloroflexi,34CTQ@301297|Dehalococcoidia	301297|Dehalococcoidia	L	Formamidopyrimidine-DNA glycosylase H2TH domain	mutM	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH
PYH3_k127_1580423_0	552811.Dehly_0095	8.149e-309	971.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,2G5J0@200795|Chloroflexi,34CQM@301297|Dehalococcoidia	301297|Dehalococcoidia	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
PYH3_k127_1580423_4	96561.Dole_0177	6.263e-45	181.0	COG1600@1|root,COG1600@2|Bacteria	2|Bacteria	C	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_1580423_3	402881.Plav_0276	9.295e-75	266.0	COG2015@1|root,COG2015@2|Bacteria,1MU82@1224|Proteobacteria,2TSM1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG2015, Alkyl sulfatase and related hydrolases	-	-	-	-	-	-	-	-	-	-	-	-	Alkyl_sulf_dimr,Lactamase_B
PYH3_k127_1580423_6	1479239.JQMU01000001_gene774	1.872e-12	67.0	COG1714@1|root,COG1714@2|Bacteria,1N1XF@1224|Proteobacteria,2UFG6@28211|Alphaproteobacteria,2K786@204457|Sphingomonadales	204457|Sphingomonadales	S	RDD family	-	-	-	-	-	-	-	-	-	-	-	-	RDD
PYH3_k127_1582293_3	485913.Krac_0163	6.534e-53	197.0	COG1506@1|root,COG1506@2|Bacteria,2G5NN@200795|Chloroflexi	2|Bacteria	E	Peptidase S9, prolyl oligopeptidase active site domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S9
PYH3_k127_1582293_0	1121422.AUMW01000006_gene679	1.318e-205	652.0	COG2368@1|root,COG2368@2|Bacteria,1TQ70@1239|Firmicutes,24AES@186801|Clostridia,260Y9@186807|Peptococcaceae	186801|Clostridia	Q	Aromatic ring hydroxylase	-	-	4.2.1.120,5.3.3.3	ko:K14534	ko00650,ko00720,ko01100,ko01120,ko01200,map00650,map00720,map01100,map01120,map01200	M00374,M00375	R03031,R10782	RC01857,RC03277	ko00000,ko00001,ko00002,ko01000	-	-	-	HpaB,HpaB_N
PYH3_k127_1582293_2	552811.Dehly_1197	2.409e-141	460.0	COG4826@1|root,COG4826@2|Bacteria,2GBWN@200795|Chloroflexi,34D50@301297|Dehalococcoidia	301297|Dehalococcoidia	M	SERine  Proteinase INhibitors	-	-	-	ko:K13963	ko05146,map05146	-	-	-	ko00000,ko00001	-	-	-	Serpin
PYH3_k127_1582293_1	1382306.JNIM01000001_gene2722	1.506e-141	466.0	COG2272@1|root,COG2272@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	-	-	-	ko:K03929	-	-	-	-	ko00000,ko01000	-	CE10	-	COesterase
PYH3_k127_1583729_1	706587.Desti_2141	4.039e-198	637.0	COG1882@1|root,COG1882@2|Bacteria,1MWBF@1224|Proteobacteria,42M5J@68525|delta/epsilon subdivisions,2WJAK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	formate C-acetyltransferase glycine radical	-	-	2.3.1.54	ko:K00656	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	-	R00212,R06987	RC00004,RC01181,RC02742,RC02833	ko00000,ko00001,ko01000	-	-	-	Gly_radical,PFL-like
PYH3_k127_1583729_2	1282876.BAOK01000001_gene1683	4.893e-59	214.0	COG4221@1|root,COG4221@2|Bacteria,1MVYG@1224|Proteobacteria,2TSTP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
PYH3_k127_1583729_4	469383.Cwoe_2271	1.101e-15	82.0	COG0346@1|root,COG0346@2|Bacteria,2I6I9@201174|Actinobacteria,4CQUH@84995|Rubrobacteria	84995|Rubrobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase_4
PYH3_k127_1583729_3	748224.HMPREF9436_01204	1.088e-33	144.0	COG1063@1|root,COG1063@2|Bacteria,1TPWP@1239|Firmicutes,24ATV@186801|Clostridia,3WI2M@541000|Ruminococcaceae	186801|Clostridia	C	COG COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
PYH3_k127_1583729_0	706587.Desti_2141	6.231e-210	677.0	COG1882@1|root,COG1882@2|Bacteria,1MWBF@1224|Proteobacteria,42M5J@68525|delta/epsilon subdivisions,2WJAK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	formate C-acetyltransferase glycine radical	-	-	2.3.1.54	ko:K00656	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	-	R00212,R06987	RC00004,RC01181,RC02742,RC02833	ko00000,ko00001,ko01000	-	-	-	Gly_radical,PFL-like
PYH3_k127_1596247_3	255470.cbdbA744	3.279e-45	175.0	COG0644@1|root,COG0644@2|Bacteria,2G7FR@200795|Chloroflexi,34CJ9@301297|Dehalococcoidia	301297|Dehalococcoidia	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	HI0933_like
PYH3_k127_1596247_4	747365.Thena_0497	8.391e-41	153.0	COG0422@1|root,COG0422@2|Bacteria,1TNZ3@1239|Firmicutes,247JE@186801|Clostridia,42FMG@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction	thiC	-	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC_Rad_SAM
PYH3_k127_1596247_6	1229172.JQFA01000002_gene5051	2.205e-06	50.0	COG0422@1|root,COG0422@2|Bacteria,1G2N9@1117|Cyanobacteria,1H931@1150|Oscillatoriales	1117|Cyanobacteria	H	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction	thiC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC_Rad_SAM
PYH3_k127_1596247_2	1123371.ATXH01000018_gene1376	2.197e-49	186.0	COG1028@1|root,COG1028@2|Bacteria,2GH4K@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
PYH3_k127_1596247_1	243164.DET0776	1.181e-69	243.0	COG0357@1|root,COG0357@2|Bacteria,2G6HF@200795|Chloroflexi,34CP5@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Specifically methylates the N7 position of a guanine in 16S rRNA	gidB	-	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB
PYH3_k127_1596247_0	311424.DhcVS_324	4.624e-148	473.0	COG0214@1|root,COG0214@2|Bacteria,2G5MW@200795|Chloroflexi,34D6P@301297|Dehalococcoidia	301297|Dehalococcoidia	H	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively	pdxS	-	4.3.3.6	ko:K06215	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SOR_SNZ
PYH3_k127_1596247_5	706587.Desti_0177	3.701e-12	69.0	COG0311@1|root,COG0311@2|Bacteria,1RI7S@1224|Proteobacteria,42SVN@68525|delta/epsilon subdivisions,2WPBZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS	pdxT	-	4.3.3.6	ko:K08681	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SNO
PYH3_k127_1619375_6	1121335.Clst_1940	5.569e-10	61.0	COG1385@1|root,COG1385@2|Bacteria,1V1CT@1239|Firmicutes,249VK@186801|Clostridia,3WIFN@541000|Ruminococcaceae	186801|Clostridia	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	rsmE	-	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
PYH3_k127_1619375_2	552811.Dehly_1218	1.951e-100	338.0	COG3684@1|root,COG3684@2|Bacteria,2G5XK@200795|Chloroflexi,34CKX@301297|Dehalococcoidia	301297|Dehalococcoidia	G	DeoC/LacD family aldolase	-	-	4.1.2.40	ko:K01635	ko00052,ko01100,ko02024,map00052,map01100,map02024	-	R01069	RC00438,RC00439	ko00000,ko00001,ko01000	-	-	-	DeoC
PYH3_k127_1619375_0	868131.MSWAN_0522	1.181e-244	771.0	COG0370@1|root,arCOG00359@2157|Archaea,2XU46@28890|Euryarchaeota,23NWG@183925|Methanobacteria	183925|Methanobacteria	P	Ferrous iron transport protein B	-	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
PYH3_k127_1619375_3	868131.MSWAN_0521	3.867e-86	291.0	COG1321@1|root,arCOG02099@2157|Archaea,2XSWC@28890|Euryarchaeota,23P0S@183925|Methanobacteria	183925|Methanobacteria	K	Iron dependent	-	-	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,Fe_dep_repress,FeoA
PYH3_k127_1619375_1	1121090.KB894694_gene2163	4.851e-104	353.0	COG0624@1|root,COG0624@2|Bacteria,1VSZV@1239|Firmicutes,4HVD0@91061|Bacilli,1ZFXJ@1386|Bacillus	91061|Bacilli	E	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
PYH3_k127_1619375_4	552811.Dehly_1001	3.941e-33	133.0	COG0607@1|root,COG0607@2|Bacteria,2G71Z@200795|Chloroflexi,34DDK@301297|Dehalococcoidia	301297|Dehalococcoidia	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
PYH3_k127_1619375_7	35754.JNYJ01000032_gene1755	0.0003415	46.0	COG2318@1|root,COG2318@2|Bacteria,2II1I@201174|Actinobacteria,4DE55@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF664)	-	-	-	-	-	-	-	-	-	-	-	-	DUF664,DinB_2
PYH3_k127_1622984_0	311424.DhcVS_1064	0.0	1157.0	COG1197@1|root,COG1197@2|Bacteria,2G5UW@200795|Chloroflexi,34CKB@301297|Dehalococcoidia	301297|Dehalococcoidia	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
PYH3_k127_1622984_2	1121472.AQWN01000005_gene2413	9.161e-06	49.0	COG2331@1|root,COG2331@2|Bacteria	2|Bacteria	P	Regulatory protein, FmdB family	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
PYH3_k127_1622984_1	1047013.AQSP01000131_gene1811	4.339e-25	109.0	COG2006@1|root,COG2768@1|root,COG2006@2|Bacteria,COG2768@2|Bacteria,2NPTK@2323|unclassified Bacteria	2|Bacteria	C	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362,Fer4,Fer4_6
PYH3_k127_1697701_24	1184251.TCELL_1231	2.092e-13	72.0	COG1013@1|root,arCOG01599@2157|Archaea,2XPWN@28889|Crenarchaeota	28889|Crenarchaeota	C	COGs COG1013 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductase beta subunit	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
PYH3_k127_1697701_2	706587.Desti_0013	5.601e-154	494.0	COG0674@1|root,COG0674@2|Bacteria,1NBSJ@1224|Proteobacteria,42MS1@68525|delta/epsilon subdivisions,2WJ97@28221|Deltaproteobacteria,2MRFE@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	ferredoxin oxidoreductase, alpha subunit	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
PYH3_k127_1697701_22	439235.Dalk_1630	4.824e-18	86.0	COG1146@1|root,COG1146@2|Bacteria,1N0QV@1224|Proteobacteria,42U2Z@68525|delta/epsilon subdivisions,2WR58@28221|Deltaproteobacteria,2MM2N@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	1.2.7.3	ko:K00176	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Fer4_7
PYH3_k127_1697701_3	552811.Dehly_1719	1.157e-109	369.0	COG0285@1|root,COG0285@2|Bacteria,2G64M@200795|Chloroflexi,34CKN@301297|Dehalococcoidia	301297|Dehalococcoidia	H	Mur ligase middle domain	folC	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M
PYH3_k127_1697701_9	1304880.JAGB01000002_gene2278	1.791e-57	218.0	COG0534@1|root,COG0534@2|Bacteria,1TNZN@1239|Firmicutes,247YX@186801|Clostridia	186801|Clostridia	V	Mate efflux family protein	mepA_10	-	-	-	-	-	-	-	-	-	-	-	MatE
PYH3_k127_1697701_7	574087.Acear_1850	1.424e-67	247.0	COG0534@1|root,COG0534@2|Bacteria,1TNZN@1239|Firmicutes,247YX@186801|Clostridia,3WAZ5@53433|Halanaerobiales	186801|Clostridia	V	efflux protein, MATE family	-	-	-	-	-	-	-	-	-	-	-	-	MatE
PYH3_k127_1697701_6	574087.Acear_1850	1.356e-70	256.0	COG0534@1|root,COG0534@2|Bacteria,1TNZN@1239|Firmicutes,247YX@186801|Clostridia,3WAZ5@53433|Halanaerobiales	186801|Clostridia	V	efflux protein, MATE family	-	-	-	-	-	-	-	-	-	-	-	-	MatE
PYH3_k127_1697701_14	56780.SYN_00428	1.291e-42	173.0	COG2271@1|root,COG2271@2|Bacteria,1QTW2@1224|Proteobacteria,42PZA@68525|delta/epsilon subdivisions,2WJ9A@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
PYH3_k127_1697701_10	192952.MM_1628	8.376e-56	199.0	COG0717@1|root,arCOG04048@2157|Archaea,2XVHA@28890|Euryarchaeota,2NBIR@224756|Methanomicrobia	224756|Methanomicrobia	F	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA	dut	-	3.6.1.23	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00053	R02100,R11896	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	dUTPase
PYH3_k127_1697701_5	552811.Dehly_1230	2.081e-77	261.0	COG2131@1|root,COG2131@2|Bacteria,2G7AC@200795|Chloroflexi,34CK4@301297|Dehalococcoidia	301297|Dehalococcoidia	F	MafB19-like deaminase	-	-	3.5.4.12	ko:K01493	ko00240,ko01100,map00240,map01100	M00429	R01663	RC00074	ko00000,ko00001,ko00002,ko01000,ko02044	-	-	-	dCMP_cyt_deam_1
PYH3_k127_1697701_8	552811.Dehly_1229	1.018e-59	211.0	COG0237@1|root,COG0237@2|Bacteria,2GARS@200795|Chloroflexi,34D6Q@301297|Dehalococcoidia	301297|Dehalococcoidia	H	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_18
PYH3_k127_1697701_4	1340434.AXVA01000010_gene5421	6.876e-79	278.0	COG1804@1|root,COG1804@2|Bacteria,1TP54@1239|Firmicutes,4HABI@91061|Bacilli,1ZB0F@1386|Bacillus	91061|Bacilli	C	acyl-CoA transferases carnitine dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
PYH3_k127_1697701_12	1123261.AXDW01000022_gene232	9.682e-50	187.0	COG1024@1|root,COG1024@2|Bacteria,1MXBB@1224|Proteobacteria,1S0NE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
PYH3_k127_1697701_15	880073.Calab_1202	9.521e-39	151.0	COG0494@1|root,COG0494@2|Bacteria,2NQ7Q@2323|unclassified Bacteria	2|Bacteria	L	NUDIX domain	nudL	GO:0003674,GO:0003824,GO:0016787,GO:0016817,GO:0016818	-	-	-	-	-	-	-	-	-	-	NUDIX
PYH3_k127_1697701_17	552811.Dehly_0260	2.08e-35	151.0	COG0586@1|root,COG0586@2|Bacteria,2GAMP@200795|Chloroflexi,34CSS@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Pfam SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
PYH3_k127_1697701_23	243164.DET1259	5.21e-16	88.0	2A49R@1|root,30SV7@2|Bacteria,2GBW7@200795|Chloroflexi,34D2F@301297|Dehalococcoidia	301297|Dehalococcoidia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_1697701_0	311424.DhcVS_1194	0.0	1170.0	COG0542@1|root,COG0542@2|Bacteria,2G62D@200795|Chloroflexi,34CVH@301297|Dehalococcoidia	301297|Dehalococcoidia	O	Belongs to the ClpA ClpB family	-	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
PYH3_k127_1697701_27	1120977.JHUX01000003_gene2083	0.0003504	43.0	2DRA2@1|root,33AVQ@2|Bacteria,1NKZA@1224|Proteobacteria,1SH2Z@1236|Gammaproteobacteria,3NQGN@468|Moraxellaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_1697701_21	161156.JQKW01000008_gene431	9.509e-21	93.0	COG1598@1|root,COG1598@2|Bacteria,2GIMX@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	HicB_like antitoxin of bacterial toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	HicB_lk_antitox
PYH3_k127_1697701_20	118161.KB235922_gene600	8.757e-24	102.0	COG1724@1|root,COG1724@2|Bacteria,1GFI8@1117|Cyanobacteria	1117|Cyanobacteria	N	HicA toxin of bacterial toxin-antitoxin,	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
PYH3_k127_1697701_13	552811.Dehly_1564	9.493e-47	170.0	COG2337@1|root,COG2337@2|Bacteria	2|Bacteria	T	Toxic component of a toxin-antitoxin (TA) module	chpA	-	-	ko:K07171	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
PYH3_k127_1697701_19	552811.Dehly_1563	8.245e-27	115.0	COG2336@1|root,COG2336@2|Bacteria,2G9F5@200795|Chloroflexi	200795|Chloroflexi	K	PFAM SpoVT AbrB domain protein	-	-	-	ko:K07172	-	-	-	-	ko00000,ko02048	-	-	-	MazE_antitoxin
PYH3_k127_1697701_26	1227497.C491_17489	2.199e-06	53.0	arCOG11305@1|root,arCOG11305@2157|Archaea,2Y4GX@28890|Euryarchaeota,2400B@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_1697701_25	1123024.AUII01000022_gene156	4.15e-12	70.0	COG1359@1|root,COG1359@2|Bacteria,2IGI1@201174|Actinobacteria	201174|Actinobacteria	S	cellular response to starvation	-	GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042594,GO:0050896,GO:0051716,GO:0071496	-	-	-	-	-	-	-	-	-	-	ABM
PYH3_k127_1697701_16	404589.Anae109_4300	4.251e-36	140.0	COG0599@1|root,COG0599@2|Bacteria,1RK66@1224|Proteobacteria	1224|Proteobacteria	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
PYH3_k127_1697701_18	1415780.JPOG01000001_gene1616	6.299e-27	121.0	COG2267@1|root,COG2267@2|Bacteria,1R299@1224|Proteobacteria,1T5JY@1236|Gammaproteobacteria,1X79P@135614|Xanthomonadales	135614|Xanthomonadales	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
PYH3_k127_1697701_1	592015.HMPREF1705_00789	4.499e-202	643.0	COG0507@1|root,COG2378@1|root,COG0507@2|Bacteria,COG2378@2|Bacteria,3TA7X@508458|Synergistetes	508458|Synergistetes	L	DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity	recD2	-	3.1.11.5	ko:K03581	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_30,HHH_4,HHH_5,Herpes_Helicase,PIF1,UvrD_C_2,WYL
PYH3_k127_1697701_11	552811.Dehly_0899	5.347e-51	189.0	COG2968@1|root,COG2968@2|Bacteria,2G6UC@200795|Chloroflexi,34CTD@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Protein of unknown function (DUF541)	-	-	-	ko:K09807	-	-	-	-	ko00000	-	-	-	SIMPL
PYH3_k127_171535_3	552811.Dehly_0760	2.528e-120	393.0	COG1217@1|root,COG1217@2|Bacteria,2G5NQ@200795|Chloroflexi,34D8B@301297|Dehalococcoidia	301297|Dehalococcoidia	T	Elongation factor G C-terminus	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
PYH3_k127_171535_0	311424.DhcVS_1417	4.715e-274	852.0	COG1032@1|root,COG1032@2|Bacteria,2GAMN@200795|Chloroflexi,34CSR@301297|Dehalococcoidia	301297|Dehalococcoidia	C	Radical SAM N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM,Radical_SAM_N
PYH3_k127_171535_11	1125863.JAFN01000001_gene1844	7.143e-27	117.0	COG0778@1|root,COG0778@2|Bacteria,1RECN@1224|Proteobacteria,42SPP@68525|delta/epsilon subdivisions,2WPPZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
PYH3_k127_171535_5	1121423.JONT01000006_gene2435	2.704e-72	253.0	COG0697@1|root,COG0697@2|Bacteria,1TR1G@1239|Firmicutes,24DN8@186801|Clostridia,261B5@186807|Peptococcaceae	186801|Clostridia	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
PYH3_k127_171535_10	552811.Dehly_0312	3.966e-31	128.0	COG0727@1|root,COG0727@2|Bacteria,2GAUI@200795|Chloroflexi,34DDR@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
PYH3_k127_171535_13	1125971.ASJB01000083_gene1689	1.88e-17	84.0	COG2331@1|root,COG2331@2|Bacteria,2IQHE@201174|Actinobacteria,4E5CR@85010|Pseudonocardiales	201174|Actinobacteria	S	regulatory protein, FmdB family	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
PYH3_k127_171535_2	1209989.TepiRe1_0436	1.361e-193	617.0	COG0459@1|root,COG0459@2|Bacteria,1TP1T@1239|Firmicutes,248BG@186801|Clostridia,42EQM@68295|Thermoanaerobacterales	186801|Clostridia	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
PYH3_k127_171535_14	1218084.BBJK01000042_gene3797	9.682e-08	56.0	COG2331@1|root,COG2331@2|Bacteria,1P6ZF@1224|Proteobacteria,2W5IV@28216|Betaproteobacteria,1KAG8@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Regulatory protein, FmdB family	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
PYH3_k127_171535_1	349161.Dred_1768	7.066e-257	801.0	COG1884@1|root,COG1884@2|Bacteria,1TQAD@1239|Firmicutes,24BDK@186801|Clostridia	186801|Clostridia	I	PFAM Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
PYH3_k127_171535_7	643648.Slip_0759	8.709e-54	192.0	COG2185@1|root,COG2185@2|Bacteria,1V3QN@1239|Firmicutes,24HAR@186801|Clostridia,42KPR@68298|Syntrophomonadaceae	186801|Clostridia	I	PFAM cobalamin B12-binding domain protein	-	-	5.4.99.2	ko:K01849	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding
PYH3_k127_171535_4	443143.GM18_2558	6.588e-82	282.0	COG1703@1|root,COG1703@2|Bacteria,1MVI0@1224|Proteobacteria,42NBN@68525|delta/epsilon subdivisions,2WK8A@28221|Deltaproteobacteria,43U0B@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	TIGRFAM LAO AO transport system ATPase	-	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK
PYH3_k127_171535_12	1379698.RBG1_1C00001G0464	1.466e-19	96.0	COG0170@1|root,COG0170@2|Bacteria,2NQ5M@2323|unclassified Bacteria	2|Bacteria	I	dolichyl monophosphate biosynthetic process	sec59	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
PYH3_k127_171535_6	243231.GSU2357	8.103e-63	229.0	COG0668@1|root,COG0668@2|Bacteria,1MXD2@1224|Proteobacteria,43C4Y@68525|delta/epsilon subdivisions,2X7FA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
PYH3_k127_171535_8	580327.Tthe_0616	5.194e-48	176.0	COG1142@1|root,COG1142@2|Bacteria,1V8SM@1239|Firmicutes,24JTG@186801|Clostridia,42G6F@68295|Thermoanaerobacterales	186801|Clostridia	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	ko:K00196	ko00633,ko00680,ko00720,ko01120,ko01200,map00633,map00680,map00720,map01120,map01200	-	R07157,R08034	RC00250,RC02800	ko00000,ko00001	-	-	-	Fer4_11
PYH3_k127_171535_9	243164.DET1131	6.578e-36	140.0	COG1251@1|root,COG1251@2|Bacteria,2G6YZ@200795|Chloroflexi,34D0M@301297|Dehalococcoidia	301297|Dehalococcoidia	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2
PYH3_k127_1721053_1	96561.Dole_1589	2.566e-37	145.0	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	catD	-	3.1.1.24	ko:K01055	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00568	R02991	RC00825	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1,Abhydrolase_4,Abhydrolase_6
PYH3_k127_1721053_2	463191.SSEG_00679	1.768e-33	146.0	COG1250@1|root,COG1250@2|Bacteria,2GJBM@201174|Actinobacteria	201174|Actinobacteria	I	3-hydroxyacyl-CoA dehydrogenase	hbd	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
PYH3_k127_1721053_0	439235.Dalk_4207	1.072e-270	848.0	COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,42MYN@68525|delta/epsilon subdivisions,2WIND@28221|Deltaproteobacteria,2MJR3@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.8.5.3,1.8.5.5	ko:K07306,ko:K08352	ko00920,ko01120,map00920,map01120	-	R09501,R10149	RC02555,RC02823	ko00000,ko00001,ko01000,ko02000	5.A.3.3,5.A.3.5	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
PYH3_k127_1737265_18	909663.KI867150_gene2688	7.449e-08	60.0	COG0664@1|root,COG0664@2|Bacteria,1NAYS@1224|Proteobacteria,42W1E@68525|delta/epsilon subdivisions,2WS96@28221|Deltaproteobacteria,2MS9T@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	PFAM Cyclic nucleotide-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
PYH3_k127_1737265_13	1449126.JQKL01000002_gene1553	6.928e-33	135.0	COG0680@1|root,COG0680@2|Bacteria	2|Bacteria	C	spore germination	hybD	-	-	ko:K03605	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	HycI
PYH3_k127_1737265_3	767817.Desgi_1166	1.193e-190	602.0	COG3259@1|root,COG3259@2|Bacteria,1UZNV@1239|Firmicutes,24F0H@186801|Clostridia,2644W@186807|Peptococcaceae	186801|Clostridia	C	Nickel-dependent hydrogenase	-	-	1.8.98.5	ko:K14126	ko00680,map00680	-	R00019,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
PYH3_k127_1737265_14	1121422.AUMW01000038_gene3023	4.527e-30	121.0	COG3259@1|root,COG3259@2|Bacteria	2|Bacteria	C	Nickel-dependent hydrogenase	-	-	1.8.98.5	ko:K14126	ko00680,map00680	-	R00019,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
PYH3_k127_1737265_7	1121422.AUMW01000038_gene3024	1.145e-118	390.0	COG1941@1|root,COG1941@2|Bacteria,1V21E@1239|Firmicutes,24GWD@186801|Clostridia,264VD@186807|Peptococcaceae	186801|Clostridia	C	NADH ubiquinone oxidoreductase, 20 Kd subunit	-	-	1.8.98.5	ko:K14128	ko00680,map00680	-	R00019,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	Oxidored_q6
PYH3_k127_1737265_16	880073.Calab_3045	1.129e-20	93.0	COG1908@1|root,COG1908@2|Bacteria,2NPFI@2323|unclassified Bacteria	2|Bacteria	C	Methyl-viologen-reducing hydrogenase, delta subunit	bamF	-	1.8.98.5,1.8.98.6	ko:K14127,ko:K14128	ko00680,map00680	-	R00019,R11943,R11944	RC00011	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_2083	Fer4,FlpD,HTH_5
PYH3_k127_1737265_15	1449126.JQKL01000002_gene1550	1.352e-29	118.0	COG1908@1|root,COG1908@2|Bacteria,1V7I6@1239|Firmicutes,24JV2@186801|Clostridia	186801|Clostridia	C	PFAM methyl-viologen-reducing hydrogenase delta subunit	-	-	1.8.98.5,1.8.98.6	ko:K14127	ko00680,map00680	-	R00019,R11943,R11944	RC00011	ko00000,ko00001,ko01000	-	-	-	FlpD
PYH3_k127_1737265_0	880073.Calab_3046	1.853e-319	1002.0	COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,2NNUW@2323|unclassified Bacteria	2|Bacteria	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_20,Fer4_7,Pyr_redox_2,Pyr_redox_3
PYH3_k127_1737265_9	880073.Calab_3046	4.911e-83	280.0	COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,2NNUW@2323|unclassified Bacteria	2|Bacteria	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_20,Fer4_7,Pyr_redox_2,Pyr_redox_3
PYH3_k127_1737265_8	880073.Calab_3047	2.429e-87	297.0	COG2048@1|root,COG2048@2|Bacteria,2NQP7@2323|unclassified Bacteria	2|Bacteria	C	Heterodisulfide reductase subunit B	hdrB	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
PYH3_k127_1737265_12	1449126.JQKL01000002_gene1547	3.714e-36	143.0	COG1150@1|root,COG1150@2|Bacteria,1V27J@1239|Firmicutes,24FU5@186801|Clostridia	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_8
PYH3_k127_1737265_17	552811.Dehly_0525	4.077e-16	78.0	COG0550@1|root,COG0550@2|Bacteria	2|Bacteria	L	DNA topoisomerase type I activity	topB	-	5.99.1.2	ko:K03169	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	DEAD,HRDC,Helicase_C,RecQ_Zn_bind,Topoisom_bac,Toprim,Toprim_Crpt
PYH3_k127_1737265_19	1205680.CAKO01000040_gene513	2.995e-07	57.0	COG0747@1|root,COG0747@2|Bacteria,1PFW6@1224|Proteobacteria,2U1GT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	ABC transporter substrate-binding protein	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
PYH3_k127_1737265_20	255470.cbdbA1487	7.062e-05	45.0	COG2801@1|root,COG2801@2|Bacteria,2G8GQ@200795|Chloroflexi,34DDP@301297|Dehalococcoidia	301297|Dehalococcoidia	L	PFAM Integrase catalytic region	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
PYH3_k127_1737265_21	1347087.CBYO010000022_gene3562	0.0008535	47.0	2DQ8S@1|root,335BX@2|Bacteria,1UIQX@1239|Firmicutes,4ISQU@91061|Bacilli	91061|Bacilli	S	Domain of unknown function (DUF4190)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4190
PYH3_k127_1737265_5	99598.Cal7507_6038	2.496e-167	535.0	COG0626@1|root,COG0626@2|Bacteria,1G43Q@1117|Cyanobacteria,1HU8Q@1161|Nostocales	1117|Cyanobacteria	E	Cys/Met metabolism PLP-dependent enzyme	metB	-	2.5.1.48,4.4.1.1	ko:K01739,ko:K01758	ko00260,ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00260,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017,M00338	R00782,R00999,R01001,R01288,R02408,R02508,R03217,R03260,R04770,R04930,R04944,R04945,R04946,R09366	RC00020,RC00056,RC00069,RC00348,RC00382,RC00420,RC00710,RC01209,RC01210,RC01245,RC02303,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Cys_Met_Meta_PP
PYH3_k127_1737265_2	643473.KB235930_gene4490	1.131e-202	640.0	COG0031@1|root,COG3620@1|root,COG0031@2|Bacteria,COG3620@2|Bacteria,1G0T4@1117|Cyanobacteria,1HM63@1161|Nostocales	1117|Cyanobacteria	EK	Pyridoxal-phosphate dependent enzyme	-	-	4.2.1.22	ko:K01697	ko00260,ko00270,ko01100,ko01130,ko01230,map00260,map00270,map01100,map01130,map01230	M00035,M00338	R00891,R01290,R04942	RC00056,RC00069,RC00256,RC00489,RC01246	ko00000,ko00001,ko00002,ko01000	-	-	-	CBS,PALP
PYH3_k127_1737265_6	456442.Mboo_2001	1.464e-158	509.0	COG2516@1|root,arCOG00662@2157|Archaea	2157|Archaea	S	PFAM Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
PYH3_k127_1737265_11	1499967.BAYZ01000079_gene881	2.829e-60	214.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	metW	-	2.3.1.31	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	-	R01776	RC00004,RC00041	ko00000,ko00001,ko01000	-	-	-	MetW
PYH3_k127_1737265_4	1499967.BAYZ01000079_gene882	1.17e-169	544.0	COG2021@1|root,COG2021@2|Bacteria,2NNZR@2323|unclassified Bacteria	2|Bacteria	E	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine	metXA	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004414,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009092,GO:0009987,GO:0016053,GO:0016407,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.31	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	-	R01776	RC00004,RC00041	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
PYH3_k127_1737265_1	552811.Dehly_0385	3.239e-211	664.0	COG2873@1|root,COG2873@2|Bacteria,2G5NS@200795|Chloroflexi	200795|Chloroflexi	E	PFAM Cys Met metabolism pyridoxal-phosphate-dependent protein	-	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	CoA_binding_2,Cys_Met_Meta_PP
PYH3_k127_1780154_7	909663.KI867149_gene3397	9.612e-28	115.0	COG4274@1|root,COG4274@2|Bacteria,1PUJQ@1224|Proteobacteria,42XN6@68525|delta/epsilon subdivisions,2WTHH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	GYD domain	-	-	-	-	-	-	-	-	-	-	-	-	GYD
PYH3_k127_1780154_14	411470.RUMGNA_03219	6.527e-12	69.0	2EBGV@1|root,335HF@2|Bacteria,1UPVS@1239|Firmicutes,24VUQ@186801|Clostridia,3Y2DM@572511|Blautia	186801|Clostridia	S	COG NOG38524 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_1780154_15	1541065.JRFE01000052_gene4179	2.823e-11	68.0	2BXJK@1|root,33AIX@2|Bacteria,1GFAX@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_1780154_13	1121367.AQXC01000020_gene369	2.911e-13	72.0	2CEAQ@1|root,2ZNPS@2|Bacteria,2HN2I@201174|Actinobacteria,22PGW@1653|Corynebacteriaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_1780154_18	1123230.ARQJ01000003_gene1063	9.202e-05	45.0	2DQE0@1|root,33689@2|Bacteria,1VH8J@1239|Firmicutes,4I062@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_1780154_16	1089548.KI783301_gene3307	4.734e-11	63.0	2B9ZZ@1|root,323DM@2|Bacteria,1V6N4@1239|Firmicutes,4IRDZ@91061|Bacilli	91061|Bacilli	S	COG NOG15344 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_1780154_9	1270196.JCKI01000008_gene1513	8.676e-22	95.0	2B9ZZ@1|root,323DM@2|Bacteria,4NTEB@976|Bacteroidetes	976|Bacteroidetes	S	COG NOG15344 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_1780154_8	1499968.TCA2_5997	7.406e-23	98.0	2DPII@1|root,3327T@2|Bacteria,1VHT9@1239|Firmicutes,4HQ1F@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_1780154_6	1121930.AQXG01000022_gene42	2.957e-30	119.0	arCOG05874@1|root,2ZJ01@2|Bacteria,4PQ1U@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_1780154_11	411467.BACCAP_04464	3.361e-16	81.0	2EPJ6@1|root,33H5U@2|Bacteria	2|Bacteria	S	Unextendable partial coding region	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_1780154_0	525904.Tter_1349	0.0	1069.0	COG0542@1|root,COG0542@2|Bacteria,2NNKN@2323|unclassified Bacteria	2|Bacteria	O	C-terminal, D2-small domain, of ClpB protein	clpC	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006457,GO:0008150,GO:0009987,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030312,GO:0040007,GO:0042802,GO:0042803,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046983,GO:0071944	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
PYH3_k127_1780154_12	273068.TTE2383	4.74e-14	75.0	COG4770@1|root,COG4770@2|Bacteria,1VA1E@1239|Firmicutes,24MUJ@186801|Clostridia,42GW2@68295|Thermoanaerobacterales	186801|Clostridia	I	PFAM Biotin lipoyl attachment	gcdC	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl
PYH3_k127_1780154_4	1385511.N783_08030	6.484e-57	208.0	COG1024@1|root,COG1024@2|Bacteria,1TQ89@1239|Firmicutes,4HCH3@91061|Bacilli,2Y8VJ@289201|Pontibacillus	91061|Bacilli	I	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
PYH3_k127_1780154_3	204669.Acid345_1213	9.202e-61	217.0	COG1024@1|root,COG1024@2|Bacteria,3Y47B@57723|Acidobacteria,2JIRS@204432|Acidobacteriia	204432|Acidobacteriia	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	-	ECH_1
PYH3_k127_1780154_1	1499680.CCFE01000023_gene2582	2.101e-136	451.0	COG0318@1|root,COG0318@2|Bacteria,1TPSX@1239|Firmicutes,4IN2H@91061|Bacilli,1ZMNA@1386|Bacillus	91061|Bacilli	IQ	AMP-binding enzyme C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
PYH3_k127_1780154_5	33898.JRHJ01000016_gene3982	7.164e-36	142.0	COG2318@1|root,COG2318@2|Bacteria,2II1I@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF664)	-	-	-	-	-	-	-	-	-	-	-	-	DUF664,DinB_2
PYH3_k127_1780154_2	580327.Tthe_1660	1.026e-131	431.0	COG1960@1|root,COG1960@2|Bacteria,1TP57@1239|Firmicutes,247UB@186801|Clostridia,42FF9@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM Acyl-CoA dehydrogenase	bcd	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016627,GO:0016628,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071949,GO:0097159,GO:1901265,GO:1901363	1.3.1.108,1.3.8.1	ko:K00248,ko:K22430	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212	-	R01175,R01178,R02661,R03172,R04751	RC00052,RC00068,RC00076,RC00120,RC00148	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
PYH3_k127_1780154_10	177437.HRM2_28730	3.81e-18	84.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,42MHP@68525|delta/epsilon subdivisions,2WJY2@28221|Deltaproteobacteria,2MHX0@213118|Desulfobacterales	28221|Deltaproteobacteria	I	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.17	ko:K01908	ko00640,ko01100,map00640,map01100	-	R00926,R01354	RC00004,RC00043,RC00070,RC02816	ko00000,ko00001,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
PYH3_k127_181824_1	552811.Dehly_0435	7.084e-190	614.0	COG1138@1|root,COG1138@2|Bacteria,2G5SZ@200795|Chloroflexi	200795|Chloroflexi	O	PFAM Cytochrome C assembly protein	ccmF	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
PYH3_k127_181824_5	552811.Dehly_0438	2.323e-72	252.0	COG1131@1|root,COG1131@2|Bacteria,2G6HN@200795|Chloroflexi,34D7R@301297|Dehalococcoidia	2|Bacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	ccmA	-	3.6.3.41	ko:K01990,ko:K02193	ko02010,map02010	M00254,M00259	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.107	-	-	ABC_tran
PYH3_k127_181824_4	552811.Dehly_0439	2.965e-76	263.0	COG2386@1|root,COG2386@2|Bacteria,2G6TN@200795|Chloroflexi	200795|Chloroflexi	O	PFAM cytochrome c-type biogenesis protein CcmB	ccmB	-	-	ko:K02194	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	CcmB
PYH3_k127_181824_3	552811.Dehly_0440	3.736e-77	263.0	COG0755@1|root,COG0755@2|Bacteria,2G6SI@200795|Chloroflexi	200795|Chloroflexi	O	PFAM Cytochrome C assembly protein	ccmC	-	-	ko:K02195	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	Cytochrom_C_asm
PYH3_k127_181824_2	552811.Dehly_0560	4.15e-123	408.0	COG2379@1|root,COG2379@2|Bacteria,2G5RZ@200795|Chloroflexi	200795|Chloroflexi	G	PFAM MOFRL domain protein	-	-	2.7.1.165	ko:K11529	ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200	M00346	R08572	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4147,MOFRL
PYH3_k127_181824_0	335543.Sfum_3911	1.389e-273	850.0	COG0458@1|root,COG0458@2|Bacteria,1NPMZ@1224|Proteobacteria,42NF3@68525|delta/epsilon subdivisions,2WM4C@28221|Deltaproteobacteria,2MQ8X@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	Carbamoyl-phosphate synthetase large chain, oligomerisation	-	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_0661	CPSase_L_D2,CPSase_L_D3,MGS
PYH3_k127_1839239_2	264732.Moth_1558	3.259e-75	261.0	COG0169@1|root,COG0169@2|Bacteria,1TQRY@1239|Firmicutes,2497S@186801|Clostridia,42ES9@68295|Thermoanaerobacterales	186801|Clostridia	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	-	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_DH,Shikimate_dh_N
PYH3_k127_1839239_3	552811.Dehly_0223	1.628e-67	236.0	COG0710@1|root,COG0710@2|Bacteria,2GBUG@200795|Chloroflexi,34CTN@301297|Dehalococcoidia	301297|Dehalococcoidia	E	Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate	aroD	-	4.2.1.10	ko:K03785	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_I
PYH3_k127_1839239_1	635013.TherJR_1740	9.9e-100	338.0	COG0337@1|root,COG0337@2|Bacteria,1TPKZ@1239|Firmicutes,248H4@186801|Clostridia,25ZZM@186807|Peptococcaceae	186801|Clostridia	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	2.7.1.71,4.2.3.4	ko:K01735,ko:K13829	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412,R03083	RC00002,RC00078,RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase
PYH3_k127_1839239_0	243164.DET0468	2.292e-162	518.0	COG2876@1|root,COG2876@2|Bacteria,2G643@200795|Chloroflexi,34D21@301297|Dehalococcoidia	301297|Dehalococcoidia	H	DAHP synthetase I family	-	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
PYH3_k127_1953305_5	255470.cbdbA1128	1.726e-34	137.0	COG2890@1|root,COG2890@2|Bacteria,2G6I8@200795|Chloroflexi,34CQQ@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS,Methyltransf_31
PYH3_k127_1953305_0	552811.Dehly_0966	1.684e-136	443.0	COG0216@1|root,COG0216@2|Bacteria,2G5UD@200795|Chloroflexi,34CMR@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
PYH3_k127_1953305_1	243164.DET1208	2.573e-115	381.0	COG1208@1|root,COG1208@2|Bacteria,2G65W@200795|Chloroflexi,34CN9@301297|Dehalococcoidia	301297|Dehalococcoidia	M	Nucleotidyl transferase	-	-	2.7.7.13	ko:K00966	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
PYH3_k127_1953305_3	243164.DET0814	2.711e-89	301.0	COG0842@1|root,COG0842@2|Bacteria,2G6PG@200795|Chloroflexi,34CJT@301297|Dehalococcoidia	301297|Dehalococcoidia	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
PYH3_k127_1953305_2	255470.cbdbA789	6.46e-104	342.0	COG1131@1|root,COG1131@2|Bacteria,2G6JW@200795|Chloroflexi,34D59@301297|Dehalococcoidia	301297|Dehalococcoidia	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
PYH3_k127_1953305_6	552811.Dehly_0810	2.774e-29	125.0	COG0671@1|root,COG0671@2|Bacteria,2G93T@200795|Chloroflexi,34CUF@301297|Dehalococcoidia	301297|Dehalococcoidia	I	phosphoesterase, PA-phosphatase related	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_1953305_8	673860.AciM339_0420	9.437e-05	51.0	arCOG03338@1|root,arCOG03338@2157|Archaea,2Y4KI@28890|Euryarchaeota,3F3GP@33867|unclassified Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_1953305_4	868595.Desca_0351	5.958e-75	258.0	COG0378@1|root,COG0378@2|Bacteria,1TS00@1239|Firmicutes,248T1@186801|Clostridia,261IK@186807|Peptococcaceae	186801|Clostridia	KO	Hydrogenase accessory protein HypB	hypB	-	-	ko:K04652	-	-	-	-	ko00000,ko03110	-	-	-	cobW
PYH3_k127_1953305_7	635013.TherJR_1303	1.292e-22	98.0	COG0309@1|root,COG0309@2|Bacteria,1TQP4@1239|Firmicutes,24963@186801|Clostridia,260QH@186807|Peptococcaceae	186801|Clostridia	O	hydrogenase expression formation protein HypE	hypE	-	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
PYH3_k127_195468_0	926569.ANT_10010	4.661e-121	396.0	COG0480@1|root,COG0480@2|Bacteria,2G63B@200795|Chloroflexi	200795|Chloroflexi	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
PYH3_k127_195468_2	525904.Tter_0711	3.149e-52	189.0	COG0049@1|root,COG0049@2|Bacteria,2NP7H@2323|unclassified Bacteria	2|Bacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA	rpsG	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0016020,GO:0016043,GO:0017148,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
PYH3_k127_195468_1	552811.Dehly_1101	7.168e-65	224.0	COG0048@1|root,COG0048@2|Bacteria,2G6EX@200795|Chloroflexi,34D33@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit	rpsL	-	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
PYH3_k127_195468_4	103690.17133561	6.569e-19	97.0	2BDP7@1|root,327CQ@2|Bacteria,1GCJ7@1117|Cyanobacteria,1HMVV@1161|Nostocales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_195468_5	880072.Desac_1565	5.03e-11	70.0	COG1586@1|root,COG1586@2|Bacteria,1PD56@1224|Proteobacteria,437VG@68525|delta/epsilon subdivisions,2WYPK@28221|Deltaproteobacteria,2MRYA@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine	-	-	4.1.1.50	ko:K01611	ko00270,ko00330,ko01100,map00270,map00330,map01100	M00034,M00133	R00178	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	AdoMet_dc
PYH3_k127_195468_3	1120985.AUMI01000018_gene3020	1.083e-27	114.0	COG1748@1|root,COG1748@2|Bacteria,1TQTN@1239|Firmicutes,4H2K0@909932|Negativicutes	909932|Negativicutes	E	Saccharopine dehydrogenase	LYS1	-	1.5.1.7	ko:K00290	ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230	M00030,M00032	R00715	RC00217,RC01532	ko00000,ko00001,ko00002,ko01000	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP
PYH3_k127_199415_21	335543.Sfum_4092	5.196e-47	172.0	COG1150@1|root,COG1150@2|Bacteria,1NFJN@1224|Proteobacteria,43B2A@68525|delta/epsilon subdivisions,2X6GB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_17
PYH3_k127_199415_12	335543.Sfum_4093	1.493e-90	306.0	COG2048@1|root,COG2048@2|Bacteria,1N37J@1224|Proteobacteria,42P51@68525|delta/epsilon subdivisions,2X6MI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Cysteine-rich domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG
PYH3_k127_199415_5	477974.Daud_0565	1.103e-158	512.0	COG1148@1|root,COG1148@2|Bacteria,1VPAD@1239|Firmicutes,25B2G@186801|Clostridia,2673V@186807|Peptococcaceae	186801|Clostridia	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Fer4,Fer4_7,Pyr_redox_2
PYH3_k127_199415_2	1125863.JAFN01000001_gene1781	2.9e-188	604.0	COG1148@1|root,COG1148@2|Bacteria,1QUMN@1224|Proteobacteria,43BMA@68525|delta/epsilon subdivisions,2X6ZG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	hdrA	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Fer4_7,FlpD,Pyr_redox_2
PYH3_k127_199415_9	335543.Sfum_4094	1.507e-108	355.0	COG1152@1|root,COG1152@2|Bacteria,1R9TR@1224|Proteobacteria,42NQK@68525|delta/epsilon subdivisions,2WKI3@28221|Deltaproteobacteria,2MR78@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_199415_1	706587.Desti_4517	7.948e-243	760.0	COG1053@1|root,COG1053@2|Bacteria,1R478@1224|Proteobacteria,42PCT@68525|delta/epsilon subdivisions,2WJIG@28221|Deltaproteobacteria,2MR41@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	FAD binding domain	-	-	1.3.5.1,1.3.5.4,1.4.3.16	ko:K00239,ko:K00278	ko00020,ko00190,ko00250,ko00650,ko00720,ko00760,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00250,map00650,map00720,map00760,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00115,M00149,M00173,M00374,M00376	R00357,R00481,R02164	RC00006,RC00045,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2
PYH3_k127_199415_24	118163.Ple7327_3576	5.503e-24	112.0	COG0457@1|root,COG0457@2|Bacteria,1G5UW@1117|Cyanobacteria	1117|Cyanobacteria	S	tetratricopeptide repeat	mom72	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_2,TPR_8
PYH3_k127_199415_25	316274.Haur_2169	2.955e-11	71.0	COG0028@1|root,COG2911@1|root,COG2931@1|root,COG3055@1|root,COG3266@1|root,COG3386@1|root,COG3409@1|root,COG0028@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria,COG3055@2|Bacteria,COG3266@2|Bacteria,COG3386@2|Bacteria,COG3409@2|Bacteria,2G9CG@200795|Chloroflexi,374U7@32061|Chloroflexia	32061|Chloroflexia	G	LamG domain protein jellyroll fold domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_3,Laminin_G_3
PYH3_k127_199415_29	1121333.JMLH01000006_gene1217	0.0001486	49.0	COG1433@1|root,COG1433@2|Bacteria,1V7KS@1239|Firmicutes,3VRZ0@526524|Erysipelotrichia	526524|Erysipelotrichia	S	COG NOG16874 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	C_GCAxxG_C_C
PYH3_k127_199415_22	1197130.BAFM01000003_gene653	7.314e-44	171.0	COG2159@1|root,arCOG01931@2157|Archaea	1197130.BAFM01000003_gene653|-	S	metal-dependent hydrolase of the TIM-barrel fold	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_199415_15	177437.HRM2_02740	4.875e-70	248.0	COG0370@1|root,COG0370@2|Bacteria,1QWMI@1224|Proteobacteria,43BSF@68525|delta/epsilon subdivisions,2X739@28221|Deltaproteobacteria,2MI8F@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Transporter of a GTP-driven Fe(2 ) uptake system	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_199415_4	1382306.JNIM01000001_gene2616	3.97e-171	558.0	COG1132@1|root,COG1132@2|Bacteria,2G66A@200795|Chloroflexi	200795|Chloroflexi	V	ABC transporter, transmembrane region	-	-	-	ko:K06147,ko:K18890	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
PYH3_k127_199415_3	485913.Krac_2496	1.139e-182	588.0	COG1132@1|root,COG1132@2|Bacteria,2G5QH@200795|Chloroflexi	200795|Chloroflexi	V	PFAM ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
PYH3_k127_199415_17	255470.cbdbA286	2.611e-53	193.0	COG1327@1|root,COG1327@2|Bacteria,2G6QI@200795|Chloroflexi,34CXD@301297|Dehalococcoidia	301297|Dehalococcoidia	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	-	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
PYH3_k127_199415_0	552811.Dehly_1284	0.0	1038.0	COG0209@1|root,COG0209@2|Bacteria,2G5PW@200795|Chloroflexi,34CT1@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdA	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_lgC,Ribonuc_red_lgN,TSCPD
PYH3_k127_199415_14	243164.DET0347	1.843e-74	256.0	COG1432@1|root,COG1432@2|Bacteria,2G7FF@200795|Chloroflexi,34CXN@301297|Dehalococcoidia	301297|Dehalococcoidia	S	NYN domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN
PYH3_k127_199415_23	552811.Dehly_0226	6.312e-29	119.0	COG0736@1|root,COG0736@2|Bacteria,2G73N@200795|Chloroflexi,34DDA@301297|Dehalococcoidia	301297|Dehalococcoidia	I	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein	acpS	-	2.7.8.7	ko:K00997	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
PYH3_k127_199415_28	1333523.L593_08035	0.0001465	53.0	COG3291@1|root,COG3979@1|root,arCOG06334@1|root,arCOG02510@2157|Archaea,arCOG06334@2157|Archaea,arCOG07581@2157|Archaea,2Y80Y@28890|Euryarchaeota,24124@183963|Halobacteria	183963|Halobacteria	G	COG3291 FOG PKD repeat	-	-	-	-	-	-	-	-	-	-	-	-	PKD
PYH3_k127_199415_19	1499967.BAYZ01000095_gene4168	1.02e-50	199.0	COG3225@1|root,COG3225@2|Bacteria,2NNVN@2323|unclassified Bacteria	2|Bacteria	N	ABC-type uncharacterized transport system	gldG	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC_transp_aux
PYH3_k127_199415_20	1499967.BAYZ01000095_gene4169	6.077e-50	186.0	COG1277@1|root,COG1277@2|Bacteria,2NPGK@2323|unclassified Bacteria	2|Bacteria	S	ABC-2 family transporter protein	yxlG	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_3,ABC_transp_aux
PYH3_k127_199415_11	671143.DAMO_0838	3.072e-93	315.0	COG1131@1|root,COG1131@2|Bacteria,2NNKB@2323|unclassified Bacteria	2|Bacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	ccmA	-	3.6.3.7	ko:K01990,ko:K09697	ko02010,ko02020,map02010,map02020	M00253,M00254	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.115	-	-	ABC_tran
PYH3_k127_199415_26	273068.TTE2564	4.708e-11	74.0	COG0760@1|root,COG0760@2|Bacteria,1TX3R@1239|Firmicutes,24C7H@186801|Clostridia,42GQY@68295|Thermoanaerobacterales	186801|Clostridia	M	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins	prsA	-	5.2.1.8	ko:K03769,ko:K07533	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_2,SurA_N_3,TPR_7
PYH3_k127_199415_6	867845.KI911784_gene881	1.552e-136	447.0	COG4608@1|root,COG4608@2|Bacteria,2G5R5@200795|Chloroflexi,3754I@32061|Chloroflexia	32061|Chloroflexia	P	TIGRFAM oligopeptide dipeptide ABC transporter, ATPase subunit	-	-	-	ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
PYH3_k127_199415_7	309801.trd_1629	1.581e-133	434.0	COG0444@1|root,COG0444@2|Bacteria,2G61B@200795|Chloroflexi,27XUE@189775|Thermomicrobia	189775|Thermomicrobia	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
PYH3_k127_199415_16	767817.Desgi_0648	1.753e-64	229.0	COG1024@1|root,COG1024@2|Bacteria,1TQ89@1239|Firmicutes,247RK@186801|Clostridia,26121@186807|Peptococcaceae	186801|Clostridia	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	4.2.1.149,5.3.3.18	ko:K07546,ko:K08299,ko:K15866	ko00360,ko00623,ko01100,ko01120,ko01220,map00360,map00623,map01100,map01120,map01220	M00418	R05599,R09837,R09839,R10675	RC00004,RC00326,RC01095,RC01435,RC02689,RC03003	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
PYH3_k127_199415_13	316274.Haur_1203	4.17e-80	275.0	COG1250@1|root,COG1250@2|Bacteria,2G6EB@200795|Chloroflexi	200795|Chloroflexi	C	3-hydroxyacyl-CoA dehydrogenase domain protein	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
PYH3_k127_199415_10	1265505.ATUG01000001_gene3893	7.287e-104	346.0	COG0074@1|root,COG0074@2|Bacteria,1MUGA@1224|Proteobacteria,42M2W@68525|delta/epsilon subdivisions,2WJBV@28221|Deltaproteobacteria,2MJ9I@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,CoA_binding,Ligase_CoA,Succ_CoA_lig
PYH3_k127_199415_27	645991.Sgly_2193	6.944e-10	63.0	2C9GM@1|root,32RPA@2|Bacteria,1VDF6@1239|Firmicutes,24N1T@186801|Clostridia,262K1@186807|Peptococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_199415_8	1265505.ATUG01000001_gene3891	4.235e-133	436.0	COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,42M5K@68525|delta/epsilon subdivisions,2WJTS@28221|Deltaproteobacteria,2MHZ2@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_2,Ligase_CoA
PYH3_k127_199415_18	656519.Halsa_0108	1.635e-52	199.0	COG0534@1|root,COG0534@2|Bacteria,1TNZN@1239|Firmicutes,247YX@186801|Clostridia,3WBA0@53433|Halanaerobiales	186801|Clostridia	V	MatE	-	-	-	-	-	-	-	-	-	-	-	-	MatE
PYH3_k127_2025355_1	521011.Mpal_0671	3.019e-77	266.0	arCOG02576@1|root,arCOG02576@2157|Archaea,2XZNM@28890|Euryarchaeota,2N9WU@224756|Methanomicrobia	224756|Methanomicrobia	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
PYH3_k127_2025355_0	552811.Dehly_0937	2.298e-254	798.0	COG1200@1|root,COG1200@2|Bacteria,2G5YM@200795|Chloroflexi,34D01@301297|Dehalococcoidia	301297|Dehalococcoidia	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
PYH3_k127_2082344_0	243164.DET1630	8.925e-87	295.0	COG0188@1|root,COG0188@2|Bacteria,2G5Q2@200795|Chloroflexi,34D9E@301297|Dehalococcoidia	301297|Dehalococcoidia	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
PYH3_k127_2082344_1	493475.GARC_3010	1.08e-54	200.0	COG2267@1|root,COG2267@2|Bacteria,1Q6AF@1224|Proteobacteria,1SNQ0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	hydrolases or acyltransferases (alpha beta hydrolase superfamily)	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
PYH3_k127_2082344_2	311424.DhcVS_1381	6.359e-20	96.0	COG1846@1|root,COG1846@2|Bacteria,2GAS6@200795|Chloroflexi,34D7U@301297|Dehalococcoidia	301297|Dehalococcoidia	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_2082344_3	1120936.KB907214_gene4261	8.365e-07	59.0	COG0326@1|root,COG0326@2|Bacteria,2GNPQ@201174|Actinobacteria,4EHC2@85012|Streptosporangiales	201174|Actinobacteria	O	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	ko:K04079	ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418	-	-	-	ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147	-	-	-	HATPase_c_3,HSP90
PYH3_k127_2106765_2	1205680.CAKO01000040_gene513	2.221e-62	237.0	COG0747@1|root,COG0747@2|Bacteria,1PFW6@1224|Proteobacteria,2U1GT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	ABC transporter substrate-binding protein	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
PYH3_k127_2106765_1	930169.B5T_03305	2.519e-98	331.0	COG1173@1|root,COG1173@2|Bacteria,1MU26@1224|Proteobacteria,1RND6@1236|Gammaproteobacteria,1XH9S@135619|Oceanospirillales	135619|Oceanospirillales	EP	N-terminal TM domain of oligopeptide transport permease C	-	-	-	ko:K02034,ko:K15582	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1,OppC_N
PYH3_k127_2106765_0	1380355.JNIJ01000026_gene1330	7.754e-105	349.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TR0N@28211|Alphaproteobacteria,3JUIB@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
PYH3_k127_2106765_6	471223.GWCH70_3340	1.733e-26	117.0	COG1309@1|root,COG1309@2|Bacteria,1UZQU@1239|Firmicutes,4HD4B@91061|Bacilli,1WG15@129337|Geobacillus	91061|Bacilli	K	Bacterial regulatory proteins, tetR family	kstR2_2	-	-	-	-	-	-	-	-	-	-	-	TetR_N
PYH3_k127_2106765_5	1121405.dsmv_0419	1.068e-30	129.0	COG1309@1|root,COG1309@2|Bacteria,1R4VA@1224|Proteobacteria,42PZX@68525|delta/epsilon subdivisions,2WK4I@28221|Deltaproteobacteria,2MI67@213118|Desulfobacterales	28221|Deltaproteobacteria	K	PFAM regulatory protein TetR	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
PYH3_k127_2106765_4	66897.DJ64_31690	5.781e-39	156.0	COG1788@1|root,COG1788@2|Bacteria,2GK61@201174|Actinobacteria	201174|Actinobacteria	I	coenzyme A transferase	pcaI	-	2.8.3.6	ko:K01031	ko00362,ko01100,ko01120,map00362,map01100,map01120	-	R02990	RC00014	ko00000,ko00001,ko01000	-	-	-	CoA_trans
PYH3_k127_2106765_3	645465.ACUR01000456_gene3077	5.778e-59	211.0	COG2057@1|root,COG2057@2|Bacteria,2GKV9@201174|Actinobacteria	201174|Actinobacteria	I	3-oxoacid CoA-transferase, B subunit	-	-	2.8.3.5	ko:K01029	ko00072,ko00280,ko00650,map00072,map00280,map00650	-	R00410	RC00014	ko00000,ko00001,ko01000	-	-	-	CoA_trans
PYH3_k127_2106765_7	1118054.CAGW01000014_gene336	9.857e-23	105.0	COG2030@1|root,COG2030@2|Bacteria,1V4PQ@1239|Firmicutes,4HGYW@91061|Bacilli	91061|Bacilli	I	N-terminal half of MaoC dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydrat_N
PYH3_k127_2106765_8	318424.EU78_10165	5.533e-11	64.0	COG1804@1|root,COG1804@2|Bacteria,2GRB0@201174|Actinobacteria,235AT@1762|Mycobacteriaceae	201174|Actinobacteria	C	PFAM CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
PYH3_k127_210892_11	479434.Sthe_2666	3.223e-13	70.0	COG0745@1|root,COG0745@2|Bacteria,2G5ND@200795|Chloroflexi,27YDQ@189775|Thermomicrobia	189775|Thermomicrobia	K	Transcriptional regulatory protein, C terminal	-	-	-	ko:K07667	ko02020,ko02024,map02020,map02024	M00454	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
PYH3_k127_210892_5	311424.DhcVS_1039	4.865e-119	394.0	COG1364@1|root,COG1364@2|Bacteria,2G64K@200795|Chloroflexi,34CYK@301297|Dehalococcoidia	301297|Dehalococcoidia	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	argJ	-	2.3.1.1,2.3.1.35	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgJ
PYH3_k127_210892_9	552811.Dehly_0925	1.643e-68	241.0	COG0548@1|root,COG0548@2|Bacteria,2G6ZG@200795|Chloroflexi,34CWW@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	-	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
PYH3_k127_210892_3	243164.DET1258	1.266e-163	523.0	COG4992@1|root,COG4992@2|Bacteria,2G5TW@200795|Chloroflexi,34D4B@301297|Dehalococcoidia	301297|Dehalococcoidia	E	Aminotransferase class-III	argD	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
PYH3_k127_210892_2	243164.DET1260	4.831e-175	558.0	COG0137@1|root,COG0137@2|Bacteria,2G5ME@200795|Chloroflexi,34CSW@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	-	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
PYH3_k127_210892_4	311424.DhcVS_1044	9.727e-159	512.0	COG0165@1|root,COG0165@2|Bacteria,2G616@200795|Chloroflexi,34D3N@301297|Dehalococcoidia	301297|Dehalococcoidia	E	arginine biosynthetic process via ornithine	argH	-	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
PYH3_k127_210892_8	574376.BAMA_08660	2.884e-75	261.0	COG0036@1|root,COG0036@2|Bacteria,1TQK8@1239|Firmicutes,4H9RW@91061|Bacilli,1ZCUF@1386|Bacillus	91061|Bacilli	G	Belongs to the ribulose-phosphate 3-epimerase family	rpe	GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046496,GO:0046872,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
PYH3_k127_210892_10	552811.Dehly_0934	3.197e-22	97.0	COG0227@1|root,COG0227@2|Bacteria,2G7E5@200795|Chloroflexi,34DI9@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Ribosomal L28 family	rpmB	-	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
PYH3_k127_210892_1	311424.DhcVS_1046	5.829e-210	665.0	COG1461@1|root,COG1461@2|Bacteria,2G61Z@200795|Chloroflexi,34CPP@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Dak1_2	-	-	-	ko:K07030	-	-	-	-	ko00000	-	-	-	Dak1_2,Dak2
PYH3_k127_210892_7	243164.DET1264	2.734e-80	276.0	COG1307@1|root,COG1307@2|Bacteria,2G6P2@200795|Chloroflexi,34CTH@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Uncharacterised protein, DegV family COG1307	-	-	-	-	-	-	-	-	-	-	-	-	DegV
PYH3_k127_210892_6	243164.DET0421	6.367e-85	291.0	COG1307@1|root,COG1307@2|Bacteria,2G6PH@200795|Chloroflexi,34CM9@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Uncharacterised protein, DegV family COG1307	-	-	-	-	-	-	-	-	-	-	-	-	DegV
PYH3_k127_210892_0	311424.DhcVS_1051	7.858e-270	853.0	COG1200@1|root,COG1200@2|Bacteria,2G5YM@200795|Chloroflexi,34D01@301297|Dehalococcoidia	301297|Dehalococcoidia	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
PYH3_k127_2134700_7	243164.DET1037	2.737e-72	252.0	COG0265@1|root,COG0265@2|Bacteria,2G8RK@200795|Chloroflexi,34CIV@301297|Dehalococcoidia	301297|Dehalococcoidia	M	Domain present in PSD-95, Dlg, and ZO-1/2.	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
PYH3_k127_2134700_0	255470.cbdbA1012	0.0	1314.0	COG0060@1|root,COG0060@2|Bacteria,2G5SN@200795|Chloroflexi,34CUX@301297|Dehalococcoidia	301297|Dehalococcoidia	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
PYH3_k127_2134700_10	311424.DhcVS_909	1.43e-48	185.0	COG1847@1|root,COG1847@2|Bacteria,2G6XH@200795|Chloroflexi,34D8E@301297|Dehalococcoidia	301297|Dehalococcoidia	S	KH domain	-	-	-	ko:K06346	-	-	-	-	ko00000	-	-	-	Jag_N,KH_4,R3H
PYH3_k127_2134700_5	311424.DhcVS_910	9.26e-79	271.0	COG0706@1|root,COG0706@2|Bacteria,2G6N0@200795|Chloroflexi,34D1I@301297|Dehalococcoidia	301297|Dehalococcoidia	U	60Kd inner membrane protein	-	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP
PYH3_k127_2134700_8	311424.DhcVS_911	3.909e-70	252.0	COG1520@1|root,COG1520@2|Bacteria,2GBGD@200795|Chloroflexi,34D1R@301297|Dehalococcoidia	301297|Dehalococcoidia	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,PQQ_3
PYH3_k127_2134700_13	311424.DhcVS_912	5.864e-29	116.0	COG0759@1|root,COG0759@2|Bacteria,2G76Q@200795|Chloroflexi,34DPX@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Could be involved in insertion of integral membrane proteins into the membrane	-	-	-	ko:K08998	-	-	-	-	ko00000	-	-	-	Haemolytic
PYH3_k127_2134700_16	243164.DET1042	8.261e-21	96.0	COG0594@1|root,COG0594@2|Bacteria,2G76W@200795|Chloroflexi,34DCW@301297|Dehalococcoidia	301297|Dehalococcoidia	J	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme	rnpA	-	3.1.26.5	ko:K03536	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_P
PYH3_k127_2134700_17	552811.Dehly_0752	1.237e-15	77.0	COG0230@1|root,COG0230@2|Bacteria,2G7BX@200795|Chloroflexi,34DIF@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Belongs to the bacterial ribosomal protein bL34 family	rpmH	-	-	ko:K02914	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L34
PYH3_k127_2134700_14	552811.Dehly_0753	5.108e-26	111.0	COG0238@1|root,COG0238@2|Bacteria,2G756@200795|Chloroflexi,34DBB@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit	rpsR	-	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
PYH3_k127_2134700_9	311424.DhcVS_916	1.375e-54	195.0	COG0629@1|root,COG0629@2|Bacteria,2G6YE@200795|Chloroflexi,34DBK@301297|Dehalococcoidia	301297|Dehalococcoidia	L	Single-strand binding protein family	ssb	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
PYH3_k127_2134700_15	1449126.JQKL01000020_gene3365	2.863e-21	96.0	COG0360@1|root,COG0360@2|Bacteria,1VA18@1239|Firmicutes,24QZQ@186801|Clostridia	186801|Clostridia	J	Binds together with S18 to 16S ribosomal RNA	rpsF	-	-	ko:K02990	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S6
PYH3_k127_2134700_18	525904.Tter_1056	1.036e-14	75.0	COG0828@1|root,COG0828@2|Bacteria,2NQ1U@2323|unclassified Bacteria	2|Bacteria	J	Ribosomal protein S21	rpsU	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02970	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S21
PYH3_k127_2134700_12	255470.cbdbA292	2.434e-37	149.0	COG1610@1|root,COG1610@2|Bacteria,2G7B8@200795|Chloroflexi,34DBW@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Yqey-like protein	-	-	-	ko:K09117	-	-	-	-	ko00000	-	-	-	YqeY
PYH3_k127_2134700_1	243164.DET0379	0.0	1215.0	COG0046@1|root,COG0046@2|Bacteria,2G5Z1@200795|Chloroflexi,34CNB@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C,PurS
PYH3_k127_2134700_4	311424.DhcVS_322	2.166e-101	337.0	COG0047@1|root,COG0047@2|Bacteria,2G6R9@200795|Chloroflexi,34CKF@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purQ	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
PYH3_k127_2134700_11	706587.Desti_3919	3.038e-46	177.0	COG0491@1|root,COG0491@2|Bacteria,1Q2C2@1224|Proteobacteria,42RVX@68525|delta/epsilon subdivisions,2WNQR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
PYH3_k127_2134700_3	243164.DET0348	7.624e-163	527.0	COG1032@1|root,COG1032@2|Bacteria,2G7YA@200795|Chloroflexi,34D62@301297|Dehalococcoidia	301297|Dehalococcoidia	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
PYH3_k127_2134700_6	1173022.Cri9333_1649	3.595e-73	259.0	COG0457@1|root,COG0457@2|Bacteria,1G20P@1117|Cyanobacteria,1H8AZ@1150|Oscillatoriales	1117|Cyanobacteria	L	Tetratricopeptide repeat	-	-	-	ko:K12600	ko03018,map03018	M00392	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	TPR_1,TPR_2,TPR_8
PYH3_k127_2134700_2	552811.Dehly_0874	1.938e-184	587.0	COG3854@1|root,COG3854@2|Bacteria,2G5P5@200795|Chloroflexi,34D2P@301297|Dehalococcoidia	301297|Dehalococcoidia	S	R3H domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA,R3H
PYH3_k127_235040_4	525904.Tter_0019	1.431e-70	244.0	COG2102@1|root,COG2102@2|Bacteria,2NR1T@2323|unclassified Bacteria	2|Bacteria	S	Diphthamide synthase	-	-	-	-	-	-	-	-	-	-	-	-	Diphthami_syn_2
PYH3_k127_235040_1	357808.RoseRS_0489	6.248e-161	516.0	COG0192@1|root,COG0192@2|Bacteria,2G5X0@200795|Chloroflexi,37571@32061|Chloroflexia	32061|Chloroflexia	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
PYH3_k127_235040_0	255470.cbdbA477	3.242e-191	604.0	COG0499@1|root,COG0499@2|Bacteria,2G5X8@200795|Chloroflexi,34D4C@301297|Dehalococcoidia	301297|Dehalococcoidia	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
PYH3_k127_235040_5	926561.KB900617_gene2070	1.868e-40	160.0	COG0613@1|root,COG0613@2|Bacteria,1TPI5@1239|Firmicutes,248H2@186801|Clostridia	186801|Clostridia	S	PHP domain	trpH	-	3.1.3.97	ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	PHP
PYH3_k127_235040_8	751944.HALDL1_14755	3.92e-12	75.0	COG0529@1|root,arCOG01040@2157|Archaea,2XWW4@28890|Euryarchaeota,23V8B@183963|Halobacteria	183963|Halobacteria	P	AAA domain	-	-	-	ko:K07028	-	-	-	-	ko00000	-	-	-	AAA_33
PYH3_k127_235040_3	243164.DET0514	7.174e-113	374.0	COG0645@1|root,COG2187@1|root,COG0645@2|Bacteria,COG2187@2|Bacteria,2G6D3@200795|Chloroflexi,34CXX@301297|Dehalococcoidia	301297|Dehalococcoidia	S	AAA domain	-	-	-	ko:K07028	-	-	-	-	ko00000	-	-	-	AAA_33
PYH3_k127_235040_6	1231241.Mc24_01983	1.89e-38	149.0	COG1618@1|root,COG1618@2|Bacteria,2GEFD@200918|Thermotogae	200918|Thermotogae	F	Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency	-	-	3.6.1.15	ko:K06928	ko00230,ko00730,ko01100,map00230,map00730,map01100	-	R00086,R00615	RC00002	ko00000,ko00001,ko01000	-	-	-	NTPase_1
PYH3_k127_235040_2	255470.cbdbA481	1.257e-115	381.0	COG0620@1|root,COG0620@2|Bacteria,2G8QD@200795|Chloroflexi,34D53@301297|Dehalococcoidia	301297|Dehalococcoidia	E	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_235040_7	255470.cbdbA482	3.067e-29	119.0	COG0005@1|root,COG0005@2|Bacteria,2G5JP@200795|Chloroflexi,34D1X@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates	mtaP	-	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
PYH3_k127_2455689_0	1078020.KEK_17373	9.286e-130	438.0	COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,2GMN4@201174|Actinobacteria,236PX@1762|Mycobacteriaceae	201174|Actinobacteria	GT	pyruvate phosphate dikinase	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
PYH3_k127_2455689_3	1123354.AUDR01000014_gene1024	4.086e-47	179.0	COG0496@1|root,COG0496@2|Bacteria,1MVHE@1224|Proteobacteria,2VIND@28216|Betaproteobacteria,1KRF6@119069|Hydrogenophilales	119069|Hydrogenophilales	S	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates	surE	-	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	SurE
PYH3_k127_2455689_2	1249634.D781_2921	2.153e-60	220.0	COG2301@1|root,COG2301@2|Bacteria,1MW0A@1224|Proteobacteria,1RNEJ@1236|Gammaproteobacteria,400JM@613|Serratia	1236|Gammaproteobacteria	G	Belongs to the HpcH HpaI aldolase family	citE	GO:0000287,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006107,GO:0008150,GO:0008152,GO:0009987,GO:0019752,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0044237,GO:0044281,GO:0044424,GO:0044464,GO:0046872,GO:0071704	4.1.3.34	ko:K01644	ko02020,map02020	-	R00362	RC00067,RC01118	ko00000,ko00001,ko01000	-	-	iSFxv_1172.SFxv_0589	HpcH_HpaI
PYH3_k127_2455689_1	1121374.KB891586_gene2775	1.363e-128	424.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,1RNB5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	acyl-CoA transferases carnitine dehydratase	caiB	GO:0003674,GO:0003824,GO:0006575,GO:0006577,GO:0006579,GO:0006807,GO:0008150,GO:0008152,GO:0008735,GO:0009056,GO:0009437,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0034641,GO:0042219,GO:0042413,GO:0044237,GO:0044248,GO:0044270,GO:0071704,GO:0097164,GO:1901564,GO:1901565,GO:1901575	2.8.3.21	ko:K08298	-	-	R10643,R10644	RC00014,RC00131	ko00000,ko01000	-	-	iEC55989_1330.EC55989_0038,iECIAI1_1343.ECIAI1_0040,iECO103_1326.ECO103_0040,iECO111_1330.ECO111_0039,iECO26_1355.ECO26_0039,iEcHS_1320.EcHS_A0042,iSF_1195.SF0035,iSFxv_1172.SFxv_0036,iS_1188.S0037	CoA_transf_3
PYH3_k127_2455689_4	933262.AXAM01000036_gene2178	4.394e-35	141.0	COG2079@1|root,COG2079@2|Bacteria,1NECN@1224|Proteobacteria,43B26@68525|delta/epsilon subdivisions,2X6G6@28221|Deltaproteobacteria,2MKC2@213118|Desulfobacterales	28221|Deltaproteobacteria	S	MmgE/PrpD family	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
PYH3_k127_2475486_2	1429916.X566_03925	2.003e-69	258.0	COG0747@1|root,COG0747@2|Bacteria,1PFW6@1224|Proteobacteria,2U1GT@28211|Alphaproteobacteria,3JUHW@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Peptide ABC transporter substrate-binding protein	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
PYH3_k127_2475486_1	1380355.JNIJ01000026_gene1331	5.799e-98	330.0	COG1173@1|root,COG1173@2|Bacteria,1MU26@1224|Proteobacteria,2VF5U@28211|Alphaproteobacteria,3JXA1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
PYH3_k127_2475486_0	1297865.APJD01000009_gene2849	2.431e-114	376.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TR0N@28211|Alphaproteobacteria,3JUIB@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
PYH3_k127_2475486_6	1206730.BAGA01000179_gene2876	5.93e-11	68.0	COG0515@1|root,COG3903@1|root,COG0515@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria,4FUTU@85025|Nocardiaceae	201174|Actinobacteria	K	activity, protein serine threonine kinase activity, protein-tyrosine kinase activity, ATP binding, regulation of transcription, DNA-dependent, protein amino acid phosphorylation	-	-	2.7.11.1	ko:K08282,ko:K13419	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	AAA_22,GerE,NB-ARC,Pkinase,TPR_12,TPR_7
PYH3_k127_2475486_3	1197906.CAJQ02000044_gene1672	9.21e-34	131.0	COG2963@1|root,COG2963@2|Bacteria,1MZ3D@1224|Proteobacteria,2UBQE@28211|Alphaproteobacteria,3JZP1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Transposase	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
PYH3_k127_2475486_4	426355.Mrad2831_2926	1.07e-21	97.0	COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria,1JSNS@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	PFAM Integrase catalytic region	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve_3
PYH3_k127_2488923_0	1121423.JONT01000032_gene2582	2.735e-99	339.0	COG0477@1|root,COG2814@2|Bacteria,1TPRN@1239|Firmicutes,249RZ@186801|Clostridia,2610Z@186807|Peptococcaceae	186801|Clostridia	U	TIGRFAM drug resistance transporter, EmrB QacA subfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
PYH3_k127_2488923_3	1118054.CAGW01000014_gene336	2.86e-27	116.0	COG2030@1|root,COG2030@2|Bacteria,1V4PQ@1239|Firmicutes,4HGYW@91061|Bacilli	91061|Bacilli	I	N-terminal half of MaoC dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydrat_N
PYH3_k127_2488923_2	552811.Dehly_0370	6.599e-38	146.0	COG2030@1|root,COG2030@2|Bacteria,2G97V@200795|Chloroflexi,34DB1@301297|Dehalococcoidia	301297|Dehalococcoidia	I	MaoC like domain	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
PYH3_k127_2488923_1	552811.Dehly_0981	3.257e-55	200.0	COG0344@1|root,COG0344@2|Bacteria,2GARY@200795|Chloroflexi,34D74@301297|Dehalococcoidia	301297|Dehalococcoidia	I	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP	-	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
PYH3_k127_2488923_5	1089544.KB912942_gene1686	8.057e-09	58.0	COG0842@1|root,COG0842@2|Bacteria,2H2PR@201174|Actinobacteria	201174|Actinobacteria	V	ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
PYH3_k127_2488923_4	439235.Dalk_0125	7.478e-09	58.0	COG2006@1|root,COG2006@2|Bacteria	2|Bacteria	U	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1,CBM9_2,DUF362
PYH3_k127_2510154_8	321327.CYA_0799	4.346e-41	164.0	COG0857@1|root,COG0857@2|Bacteria,1G0QB@1117|Cyanobacteria,1GZVA@1129|Synechococcus	1117|Cyanobacteria	C	BioD-like N-terminal domain of phosphotransacetylase	pta	-	-	ko:K06873	-	-	-	-	ko00000	-	-	-	AAA_26,DRTGG
PYH3_k127_2510154_6	456442.Mboo_1374	3.02e-45	175.0	COG3640@1|root,arCOG00587@2157|Archaea,2XT61@28890|Euryarchaeota	28890|Euryarchaeota	D	PFAM Cobyrinic acid a,c-diamide synthase	-	-	-	ko:K07321	-	-	-	-	ko00000	-	-	-	AAA_31
PYH3_k127_2510154_5	552811.Dehly_0959	1.259e-47	181.0	COG1763@1|root,COG1763@2|Bacteria	2|Bacteria	H	Mo-molybdopterin cofactor metabolic process	mobB	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0005488,GO:0005525,GO:0017076,GO:0019001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363	2.10.1.1,2.7.7.77	ko:K02379,ko:K03750,ko:K03752,ko:K03753,ko:K13818	ko00790,ko01100,map00790,map01100	-	R09735,R11581	RC03462	ko00000,ko00001,ko01000	-	-	iB21_1397.B21_03691,iBWG_1329.BWG_3527,iECBD_1354.ECBD_4174,iECDH1ME8569_1439.ECDH1ME8569_3728,iEcDH1_1363.EcDH1_4130,iJO1366.b3856,iSbBS512_1146.SbBS512_E4328,iY75_1357.Y75_RS17805	MoCF_biosynth,MobB,MoeA_C,MoeA_N,NTP_transf_3
PYH3_k127_2510154_9	370438.PTH_0581	5.272e-40	153.0	COG0822@1|root,COG0822@2|Bacteria,1VCI2@1239|Firmicutes,24MWW@186801|Clostridia,265KS@186807|Peptococcaceae	186801|Clostridia	C	NifU-like N terminal domain	-	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
PYH3_k127_2510154_3	243164.DET0104	2.032e-104	350.0	COG0489@1|root,COG0489@2|Bacteria,2G60P@200795|Chloroflexi,34D5X@301297|Dehalococcoidia	301297|Dehalococcoidia	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	-	-	-	ko:K03605	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	ParA
PYH3_k127_2510154_7	710687.KI912270_gene78	1.959e-42	166.0	COG1028@1|root,COG1028@2|Bacteria,2GIRG@201174|Actinobacteria,235Q1@1762|Mycobacteriaceae	201174|Actinobacteria	IQ	Short-chain dehydrogenase reductase sdr	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
PYH3_k127_2510154_4	243164.DET0460	9.576e-93	313.0	COG0287@1|root,COG0287@2|Bacteria,2GAKF@200795|Chloroflexi,34CNR@301297|Dehalococcoidia	301297|Dehalococcoidia	C	Prephenate dehydrogenase	-	-	1.3.1.12	ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025	R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	PDH
PYH3_k127_2510154_1	552811.Dehly_0218	6.75e-133	434.0	COG0077@1|root,COG1605@1|root,COG0077@2|Bacteria,COG1605@2|Bacteria,2G6AP@200795|Chloroflexi,34CPM@301297|Dehalococcoidia	301297|Dehalococcoidia	E	Chorismate mutase type II	-	-	4.2.1.51,5.4.99.5	ko:K14170	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R00691,R01373,R01715	RC00360,RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,CM_2,PDT
PYH3_k127_2510154_0	255470.cbdbA425	7.938e-142	458.0	COG0082@1|root,COG0082@2|Bacteria,2G645@200795|Chloroflexi,34D7C@301297|Dehalococcoidia	301297|Dehalococcoidia	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	-	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
PYH3_k127_2510154_2	552811.Dehly_0220	2.92e-112	376.0	COG0128@1|root,COG0128@2|Bacteria,2G6S6@200795|Chloroflexi,34CNP@301297|Dehalococcoidia	301297|Dehalococcoidia	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
PYH3_k127_2510154_11	1120985.AUMI01000014_gene1190	1.059e-33	136.0	COG0703@1|root,COG0703@2|Bacteria,1VA6Z@1239|Firmicutes,4H4XC@909932|Negativicutes	909932|Negativicutes	E	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	aroK	-	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	SKI
PYH3_k127_2510154_10	264732.Moth_1558	6.991e-40	154.0	COG0169@1|root,COG0169@2|Bacteria,1TQRY@1239|Firmicutes,2497S@186801|Clostridia,42ES9@68295|Thermoanaerobacterales	186801|Clostridia	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	-	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_DH,Shikimate_dh_N
PYH3_k127_2527454_0	311424.DhcVS_933	3.574e-99	331.0	COG1236@1|root,COG1236@2|Bacteria,2G62G@200795|Chloroflexi,34D19@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Beta-Casp domain	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B_6,RMMBL
PYH3_k127_2527454_1	552811.Dehly_0379	1.637e-94	314.0	COG1611@1|root,COG1611@2|Bacteria,2G6IB@200795|Chloroflexi	200795|Chloroflexi	S	Belongs to the LOG family	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
PYH3_k127_2527454_4	760568.Desku_2278	1.235e-10	70.0	COG0235@1|root,COG0235@2|Bacteria,1TPDV@1239|Firmicutes,248KI@186801|Clostridia,261R6@186807|Peptococcaceae	186801|Clostridia	G	PFAM Class II aldolase	-	-	4.1.2.17	ko:K01628	ko00051,ko01120,map00051,map01120	-	R02262	RC00603,RC00604	ko00000,ko00001,ko01000	-	-	-	Aldolase_II
PYH3_k127_2527454_2	42256.RradSPS_0589	1.663e-26	113.0	COG3185@1|root,COG3185@2|Bacteria	2|Bacteria	E	4-Hydroxyphenylpyruvate dioxygenase	-	-	5.1.99.1	ko:K05606,ko:K17315	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,ko02010,map00280,map00630,map00640,map00720,map01100,map01120,map01200,map02010	M00373,M00375,M00376,M00605,M00741	R02765,R09979	RC00780,RC02739	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.1.24,3.A.1.1.30	-	-	Glyoxalase_3,Glyoxalase_4
PYH3_k127_2527454_3	1280953.HOC_18524	1.492e-23	104.0	COG2272@1|root,COG2272@2|Bacteria,1MVQZ@1224|Proteobacteria,2TTHT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Belongs to the type-B carboxylesterase lipase family	-	-	-	ko:K03929	-	-	-	-	ko00000,ko01000	-	CE10	-	COesterase
PYH3_k127_2537392_7	1122947.FR7_1837	4.089e-05	48.0	COG2050@1|root,COG2050@2|Bacteria,1V824@1239|Firmicutes,4H4QB@909932|Negativicutes	909932|Negativicutes	Q	Thioesterase superfamily protein	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
PYH3_k127_2537392_2	1382306.JNIM01000001_gene1984	9.977e-55	200.0	COG0637@1|root,COG0637@2|Bacteria,2G6ZZ@200795|Chloroflexi	200795|Chloroflexi	O	TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3	-	-	5.4.2.6	ko:K01838	ko00500,map00500	-	R02728,R11310	RC00408	ko00000,ko00001,ko01000	-	-	-	HAD_2,Peptidase_M22
PYH3_k127_2537392_3	1121929.KB898684_gene1985	4.346e-48	176.0	COG0105@1|root,COG0105@2|Bacteria,1V44G@1239|Firmicutes,4HH8C@91061|Bacilli,470TD@74385|Gracilibacillus	91061|Bacilli	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:0072521,GO:0072527,GO:1901360,GO:1901564	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
PYH3_k127_2537392_5	485913.Krac_10277	1.146e-33	133.0	COG0799@1|root,COG0799@2|Bacteria,2G77A@200795|Chloroflexi	200795|Chloroflexi	J	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation	rsfS	-	-	ko:K09710	-	-	-	-	ko00000,ko03009	-	-	-	RsfS
PYH3_k127_2537392_0	311424.DhcVS_25	2.554e-83	284.0	COG0569@1|root,COG0569@2|Bacteria,2G6J8@200795|Chloroflexi,34CKI@301297|Dehalococcoidia	301297|Dehalococcoidia	C	TrkA-C domain	-	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
PYH3_k127_2537392_1	552811.Dehly_1508	9.515e-62	214.0	COG0569@1|root,COG0569@2|Bacteria,2G71A@200795|Chloroflexi,34DCB@301297|Dehalococcoidia	301297|Dehalococcoidia	C	TrkA-N domain	-	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_N
PYH3_k127_2537392_4	311424.DhcVS_27	2.621e-44	164.0	COG0589@1|root,COG0589@2|Bacteria,2G7D7@200795|Chloroflexi,34DAT@301297|Dehalococcoidia	301297|Dehalococcoidia	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
PYH3_k127_2537392_6	797304.Natgr_0819	1.335e-26	116.0	COG0003@1|root,arCOG02849@2157|Archaea,2XV9W@28890|Euryarchaeota,23UAT@183963|Halobacteria	2157|Archaea	D	Arsenite-activated ATPase ArsA	arsA4	-	3.6.3.16	ko:K01551	-	-	-	-	ko00000,ko01000,ko02000	3.A.19.1,3.A.21.1,3.A.4.1	-	-	ArsA_ATPase
PYH3_k127_2570832_2	1410630.JNKP01000006_gene199	4.488e-11	68.0	2EFXE@1|root,339PN@2|Bacteria,1VPU7@1239|Firmicutes,24VU8@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_2570832_3	68170.KL590487_gene8989	3.391e-08	64.0	COG5180@1|root,COG5180@2|Bacteria,2GKJ7@201174|Actinobacteria,4E186@85010|Pseudonocardiales	201174|Actinobacteria	A	pathogenesis	-	-	-	-	-	-	-	-	-	-	-	-	GPDPase_memb
PYH3_k127_2570832_1	1380390.JIAT01000010_gene3877	1.076e-31	132.0	2DBMA@1|root,2Z9Y3@2|Bacteria,2I9ER@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF4389)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4389
PYH3_k127_2570832_0	994573.T472_0206040	2.206e-32	134.0	2DTR7@1|root,33MCI@2|Bacteria,1W5BS@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_268636_3	479434.Sthe_1360	7.696e-25	112.0	COG2452@1|root,COG2452@2|Bacteria,2G789@200795|Chloroflexi,27YB6@189775|Thermomicrobia	189775|Thermomicrobia	L	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17
PYH3_k127_268636_2	697281.Mahau_0753	3.451e-28	128.0	COG0614@1|root,COG0614@2|Bacteria,1UNE3@1239|Firmicutes,24AKE@186801|Clostridia,42FIR@68295|Thermoanaerobacterales	186801|Clostridia	P	PFAM periplasmic binding protein	yvrC	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
PYH3_k127_268636_0	1828.JOKB01000036_gene1393	1.078e-55	207.0	COG0609@1|root,COG0609@2|Bacteria,2GJB9@201174|Actinobacteria,4FW2C@85025|Nocardiaceae	201174|Actinobacteria	P	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily	-	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
PYH3_k127_268636_1	571.MC52_19790	1.535e-34	145.0	COG1120@1|root,COG1120@2|Bacteria,1MUNG@1224|Proteobacteria,1RRII@1236|Gammaproteobacteria	1236|Gammaproteobacteria	HP	(ABC) transporter	fecE	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
PYH3_k127_268636_4	323098.Nwi_0833	3.217e-13	77.0	COG1192@1|root,COG1192@2|Bacteria,1N449@1224|Proteobacteria,2UEVC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	D	Cobyrinic acid a,c-diamide synthase	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
PYH3_k127_2692442_10	1089553.Tph_c28000	8.138e-46	171.0	COG0407@1|root,COG0407@2|Bacteria,1TPQ6@1239|Firmicutes,25DH9@186801|Clostridia	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
PYH3_k127_2692442_7	1089553.Tph_c28000	2.458e-54	206.0	COG0407@1|root,COG0407@2|Bacteria,1TPQ6@1239|Firmicutes,25DH9@186801|Clostridia	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
PYH3_k127_2692442_8	1089553.Tph_c28000	2.003e-50	199.0	COG0407@1|root,COG0407@2|Bacteria,1TPQ6@1239|Firmicutes,25DH9@186801|Clostridia	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
PYH3_k127_2692442_4	1089553.Tph_c28000	1.331e-66	241.0	COG0407@1|root,COG0407@2|Bacteria,1TPQ6@1239|Firmicutes,25DH9@186801|Clostridia	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
PYH3_k127_2692442_9	1304880.JAGB01000002_gene1616	5.075e-50	187.0	COG1410@1|root,COG1410@2|Bacteria,1V5ZS@1239|Firmicutes,24I4A@186801|Clostridia	186801|Clostridia	E	PFAM Vitamin B12 dependent methionine synthase, activation domain	-	-	-	-	-	-	-	-	-	-	-	-	Met_synt_B12
PYH3_k127_2692442_5	1089553.Tph_c28000	6.119e-64	235.0	COG0407@1|root,COG0407@2|Bacteria,1TPQ6@1239|Firmicutes,25DH9@186801|Clostridia	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
PYH3_k127_2692442_6	1205680.CAKO01000040_gene513	7.391e-64	239.0	COG0747@1|root,COG0747@2|Bacteria,1PFW6@1224|Proteobacteria,2U1GT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	ABC transporter substrate-binding protein	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
PYH3_k127_2692442_2	1394178.AWOO02000015_gene7055	2.717e-139	473.0	COG1804@1|root,COG1804@2|Bacteria,2GMIW@201174|Actinobacteria,4EHHR@85012|Streptosporangiales	201174|Actinobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
PYH3_k127_2692442_0	1499967.BAYZ01000005_gene5441	8.127e-152	501.0	COG3894@1|root,COG3894@2|Bacteria,2NQ3X@2323|unclassified Bacteria	2|Bacteria	C	Domain of unknown function (DUF4445)	nqrF	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
PYH3_k127_2692442_3	935948.KE386495_gene1407	1.182e-72	254.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1TPYV@1239|Firmicutes,248JB@186801|Clostridia,42FHS@68295|Thermoanaerobacterales	186801|Clostridia	H	PFAM homocysteine S-methyltransferase	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
PYH3_k127_2692442_1	1380391.JIAS01000017_gene443	5.789e-151	494.0	COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,2TRBN@28211|Alphaproteobacteria,2JXMW@204441|Rhodospirillales	204441|Rhodospirillales	EQ	Hydantoinase/oxoprolinase N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	Hydant_A_N,Hydantoinase_A
PYH3_k127_2773144_3	243164.DET0323	1.083e-37	156.0	COG4974@1|root,COG4974@2|Bacteria	2|Bacteria	L	Belongs to the 'phage' integrase family	-	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Arm-DNA-bind_4,Phage_int_SAM_1,Phage_integrase
PYH3_k127_2773144_4	243164.DET0323	8.333e-05	51.0	COG4974@1|root,COG4974@2|Bacteria	2|Bacteria	L	Belongs to the 'phage' integrase family	-	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Arm-DNA-bind_4,Phage_int_SAM_1,Phage_integrase
PYH3_k127_2773144_1	338963.Pcar_3127	1.122e-79	276.0	COG1226@1|root,COG1226@2|Bacteria,1MU1R@1224|Proteobacteria,42MW6@68525|delta/epsilon subdivisions,2WIYU@28221|Deltaproteobacteria,43UJB@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	Ion channel	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans_2,TrkA_C,TrkA_N
PYH3_k127_2773144_0	767817.Desgi_0669	2.029e-103	349.0	COG1804@1|root,COG1804@2|Bacteria,1TP54@1239|Firmicutes,24AFB@186801|Clostridia	186801|Clostridia	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
PYH3_k127_2773144_2	1101188.KI912155_gene2983	1.486e-63	231.0	COG1804@1|root,COG1804@2|Bacteria,2IB9E@201174|Actinobacteria	201174|Actinobacteria	C	L-carnitine dehydratase bile acid-inducible protein F	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
PYH3_k127_2776039_0	56107.Cylst_3397	5.469e-39	166.0	COG0656@1|root,COG0656@2|Bacteria,1G6K0@1117|Cyanobacteria,1HNPA@1161|Nostocales	1117|Cyanobacteria	M	Domain of unknown function (DUF4157)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4157,Ntox11
PYH3_k127_2776039_1	1487953.JMKF01000079_gene4149	0.0004424	45.0	COG4385@1|root,COG4385@2|Bacteria,1G2G6@1117|Cyanobacteria,1H77I@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM Phage tail protein (Tail_P2_I)	-	-	-	-	-	-	-	-	-	-	-	-	Tail_P2_I
PYH3_k127_282957_0	243164.DET1464	0.0	1470.0	COG0587@1|root,COG0587@2|Bacteria,2G5IY@200795|Chloroflexi,34CSK@301297|Dehalococcoidia	301297|Dehalococcoidia	L	DNA-directed DNA polymerase	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
PYH3_k127_2864159_7	439235.Dalk_4207	9.127e-45	164.0	COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,42MYN@68525|delta/epsilon subdivisions,2WIND@28221|Deltaproteobacteria,2MJR3@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.8.5.3,1.8.5.5	ko:K07306,ko:K08352	ko00920,ko01120,map00920,map01120	-	R09501,R10149	RC02555,RC02823	ko00000,ko00001,ko01000,ko02000	5.A.3.3,5.A.3.5	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
PYH3_k127_2864159_9	1304888.ATWF01000001_gene536	1.713e-23	117.0	COG0437@1|root,COG0437@2|Bacteria,2GG9E@200930|Deferribacteres	200930|Deferribacteres	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	ko:K07307	ko00920,map00920	-	R09501	RC02555	ko00000,ko00001,ko02000	5.A.3.3	-	-	Fer4_11
PYH3_k127_2864159_3	880073.Calab_3046	1.166e-96	341.0	COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,2NNUW@2323|unclassified Bacteria	2|Bacteria	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_20,Fer4_7,Pyr_redox_2,Pyr_redox_3
PYH3_k127_2864159_5	321327.CYA_2257	1.333e-60	221.0	COG0524@1|root,COG0524@2|Bacteria,1G2YU@1117|Cyanobacteria,1H46E@1129|Synechococcus	1117|Cyanobacteria	H	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway	rbsK	-	2.7.1.15	ko:K00852	ko00030,map00030	-	R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
PYH3_k127_2864159_1	1120950.KB892759_gene6224	2.361e-113	381.0	COG1397@1|root,COG1397@2|Bacteria,2GMYG@201174|Actinobacteria,4DTNF@85009|Propionibacteriales	201174|Actinobacteria	O	ADP-ribosylglycohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	ADP_ribosyl_GH
PYH3_k127_2864159_12	1267534.KB906758_gene2500	1.025e-06	60.0	COG2931@1|root,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,VCBS
PYH3_k127_2864159_0	1297863.APJF01000020_gene2746	0.0	1224.0	COG0439@1|root,COG1038@1|root,COG4799@1|root,COG0439@2|Bacteria,COG1038@2|Bacteria,COG4799@2|Bacteria,1MU4H@1224|Proteobacteria,2TWYZ@28211|Alphaproteobacteria,3JUPC@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Biotin carboxylase C-terminal domain	MA20_04765	-	-	-	-	-	-	-	-	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,Carboxyl_trans
PYH3_k127_2864159_2	1121422.AUMW01000011_gene93	1.54e-109	365.0	COG2070@1|root,COG2070@2|Bacteria,1VTQJ@1239|Firmicutes,24ZN0@186801|Clostridia,26495@186807|Peptococcaceae	186801|Clostridia	S	FMN-dependent dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	NMO
PYH3_k127_2864159_4	257310.BB4331	6.1e-92	314.0	COG0183@1|root,COG0183@2|Bacteria,1MUZV@1224|Proteobacteria,2VNG0@28216|Betaproteobacteria	28216|Betaproteobacteria	I	acetyl-coa acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_2864159_8	1382306.JNIM01000001_gene3012	5.113e-41	155.0	COG1545@1|root,COG1545@2|Bacteria,2G73Z@200795|Chloroflexi	200795|Chloroflexi	S	DUF35 OB-fold domain, acyl-CoA-associated	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
PYH3_k127_2864159_6	690585.JNNU01000013_gene3550	5.321e-50	188.0	COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,2TRIH@28211|Alphaproteobacteria,4B7VA@82115|Rhizobiaceae	28211|Alphaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	caiD	-	4.2.1.149	ko:K08299	-	-	R10675	RC01095	ko00000,ko01000	-	-	-	ECH_1
PYH3_k127_2864159_10	316067.Geob_1166	4.526e-16	81.0	COG2050@1|root,COG2050@2|Bacteria,1N61W@1224|Proteobacteria,42U4S@68525|delta/epsilon subdivisions,2WQWD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
PYH3_k127_2864159_11	479432.Sros_1600	4.487e-08	66.0	COG0457@1|root,COG3629@1|root,COG3899@1|root,COG0457@2|Bacteria,COG3629@2|Bacteria,COG3899@2|Bacteria,2I2U4@201174|Actinobacteria,4EMDD@85012|Streptosporangiales	201174|Actinobacteria	K	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD,GerE,Trans_reg_C
PYH3_k127_2868380_0	311424.DhcVS_1196	1.009e-180	571.0	COG0034@1|root,COG0034@2|Bacteria,2G61T@200795|Chloroflexi,34CJ3@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_7,Pribosyltran
PYH3_k127_2868380_4	490899.DKAM_0930	6.364e-62	231.0	COG1042@1|root,arCOG01340@2157|Archaea,2XPR9@28889|Crenarchaeota	28889|Crenarchaeota	C	PFAM CoA-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
PYH3_k127_2868380_6	255470.cbdbA490	1.284e-46	174.0	COG1670@1|root,COG1670@2|Bacteria,2GAMB@200795|Chloroflexi,34CRJ@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
PYH3_k127_2868380_5	1382356.JQMP01000001_gene988	4.762e-53	199.0	COG1413@1|root,COG1413@2|Bacteria,2G6MW@200795|Chloroflexi,27Y7K@189775|Thermomicrobia	189775|Thermomicrobia	C	PBS lyase HEAT-like repeat	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
PYH3_k127_2868380_3	243164.DET0525	3.081e-92	310.0	COG2047@1|root,COG2047@2|Bacteria,2G9KI@200795|Chloroflexi,34CKE@301297|Dehalococcoidia	301297|Dehalococcoidia	S	PAC2 family	-	-	-	ko:K07159	-	-	-	-	ko00000	-	-	-	PAC2
PYH3_k127_2868380_2	255470.cbdbA494	1.109e-134	442.0	COG0312@1|root,COG0312@2|Bacteria,2GANY@200795|Chloroflexi,34CWZ@301297|Dehalococcoidia	301297|Dehalococcoidia	L	Putative modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
PYH3_k127_2868380_1	243164.DET0527	9.545e-155	495.0	COG0312@1|root,COG0312@2|Bacteria,2GBVJ@200795|Chloroflexi,34CYG@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Putative modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
PYH3_k127_2886967_6	269799.Gmet_2202	3.381e-68	243.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,42PDA@68525|delta/epsilon subdivisions,2WK05@28221|Deltaproteobacteria,43S9E@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	NADH:flavin oxidoreductase / NADH oxidase family	-	-	1.3.1.34	ko:K00219	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_FMN,Pyr_redox_2
PYH3_k127_2886967_4	1192034.CAP_6420	8.076e-79	272.0	COG0596@1|root,COG0596@2|Bacteria,1N5ZI@1224|Proteobacteria	1224|Proteobacteria	P	Alpha beta hydrolase	ephA	-	-	ko:K22318	-	-	-	-	ko00000	-	-	-	Abhydrolase_1
PYH3_k127_2886967_5	1449126.JQKL01000016_gene2873	4.915e-71	254.0	COG1804@1|root,COG1804@2|Bacteria,1TP54@1239|Firmicutes,24AFB@186801|Clostridia	186801|Clostridia	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
PYH3_k127_2886967_7	1009370.ALO_16771	1.198e-59	221.0	COG1804@1|root,COG1804@2|Bacteria,1TP54@1239|Firmicutes,4H6FT@909932|Negativicutes	909932|Negativicutes	H	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
PYH3_k127_2886967_10	357808.RoseRS_4618	2.654e-24	112.0	COG1668@1|root,COG1668@2|Bacteria,2G76A@200795|Chloroflexi,3777A@32061|Chloroflexia	32061|Chloroflexia	CP	ABC-2 family transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_2
PYH3_k127_2886967_1	867845.KI911784_gene167	4.15e-87	297.0	COG1131@1|root,COG1131@2|Bacteria,2G6HA@200795|Chloroflexi,376NC@32061|Chloroflexia	32061|Chloroflexia	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
PYH3_k127_2886967_8	552811.Dehly_0425	3.81e-54	197.0	COG1974@1|root,COG1974@2|Bacteria,2G6NC@200795|Chloroflexi,34CY4@301297|Dehalococcoidia	200795|Chloroflexi	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	-	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
PYH3_k127_2886967_9	311424.DhcVS_1080	2.645e-35	139.0	COG1278@1|root,COG1278@2|Bacteria,2G79W@200795|Chloroflexi,34DCQ@301297|Dehalococcoidia	301297|Dehalococcoidia	K	Probable zinc-ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	zf-trcl
PYH3_k127_2886967_3	552811.Dehly_0143	5.468e-81	281.0	COG1597@1|root,COG1597@2|Bacteria,2G6UK@200795|Chloroflexi,34CPQ@301297|Dehalococcoidia	301297|Dehalococcoidia	I	Diacylglycerol kinase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
PYH3_k127_2886967_0	760568.Desku_0624	2.499e-92	317.0	COG1454@1|root,COG1454@2|Bacteria,1TPB4@1239|Firmicutes,247IQ@186801|Clostridia,2609H@186807|Peptococcaceae	186801|Clostridia	C	alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Fe-ADH
PYH3_k127_2886967_2	886293.Sinac_1238	8.983e-83	286.0	COG0330@1|root,COG0330@2|Bacteria,2J20E@203682|Planctomycetes	203682|Planctomycetes	O	PFAM SPFH domain Band 7 family	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
PYH3_k127_2886967_11	888727.HMPREF9092_1193	3.351e-18	92.0	COG2025@1|root,COG2025@2|Bacteria,1TPC8@1239|Firmicutes,247NF@186801|Clostridia,3WCFX@538999|Clostridiales incertae sedis	186801|Clostridia	C	PFAM Electron transfer flavoprotein domain	etfA	-	1.3.1.108	ko:K03522,ko:K22432	-	-	-	-	ko00000,ko01000,ko04147	-	-	-	ETF,ETF_alpha,Fer4
PYH3_k127_293567_3	360107.CHAB381_1743	2.602e-06	49.0	COG0820@1|root,COG0820@2|Bacteria,1MUYK@1224|Proteobacteria,42N69@68525|delta/epsilon subdivisions,2YN3J@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	-	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Fer4_14,Radical_SAM
PYH3_k127_293567_0	552811.Dehly_0574	9.656e-157	501.0	COG0206@1|root,COG0206@2|Bacteria,2G5V2@200795|Chloroflexi,34D9X@301297|Dehalococcoidia	200795|Chloroflexi	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
PYH3_k127_293567_1	311424.DhcVS_283	3.566e-153	493.0	COG0849@1|root,COG0849@2|Bacteria,2G5V5@200795|Chloroflexi,34CNF@301297|Dehalococcoidia	301297|Dehalococcoidia	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	-	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
PYH3_k127_293567_4	255470.cbdbA837	8.558e-05	47.0	2A4FI@1|root,30T1H@2|Bacteria,2GAXA@200795|Chloroflexi,34DIQ@301297|Dehalococcoidia	301297|Dehalococcoidia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_293567_2	243164.DET0639	5.18e-20	94.0	2E9WR@1|root,3342G@2|Bacteria,2GASC@200795|Chloroflexi,34D85@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Family of unknown function (DUF5343)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5343
PYH3_k127_2937254_21	589865.DaAHT2_0828	1.048e-37	145.0	COG0190@1|root,COG0190@2|Bacteria,1MWU4@1224|Proteobacteria,42MW0@68525|delta/epsilon subdivisions,2WJ90@28221|Deltaproteobacteria,2MHRX@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	-	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
PYH3_k127_2937254_11	243164.DET0669	1.284e-82	282.0	COG3640@1|root,COG3640@2|Bacteria,2GBTX@200795|Chloroflexi,34CQK@301297|Dehalococcoidia	301297|Dehalococcoidia	D	AAA domain	-	-	-	ko:K07321	-	-	-	-	ko00000	-	-	-	CbiA
PYH3_k127_2937254_0	335543.Sfum_2687	9.552e-304	939.0	COG2759@1|root,COG2759@2|Bacteria,1MUR8@1224|Proteobacteria,42MKE@68525|delta/epsilon subdivisions,2WJF1@28221|Deltaproteobacteria,2MR3P@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	PFAM Formate--tetrahydrofolate ligase	fhs	-	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
PYH3_k127_2937254_8	439235.Dalk_4371	4.161e-87	295.0	COG3640@1|root,COG3640@2|Bacteria,1RB02@1224|Proteobacteria,42NBP@68525|delta/epsilon subdivisions,2WKS7@28221|Deltaproteobacteria,2MJA2@213118|Desulfobacterales	28221|Deltaproteobacteria	D	PFAM Cobyrinic acid ac-diamide synthase	cooC	-	-	ko:K07321	-	-	-	-	ko00000	-	-	-	CbiA
PYH3_k127_2937254_14	290402.Cbei_3971	3.879e-56	206.0	COG4714@1|root,COG4714@2|Bacteria,1V3G2@1239|Firmicutes,24D6X@186801|Clostridia,36FSK@31979|Clostridiaceae	186801|Clostridia	S	Protein of unknown function (DUF2167)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2167
PYH3_k127_2937254_23	243164.DET0661	6.351e-36	139.0	COG3118@1|root,COG3118@2|Bacteria,2G6U1@200795|Chloroflexi,34DD1@301297|Dehalococcoidia	301297|Dehalococcoidia	O	Thioredoxin	trx	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
PYH3_k127_2937254_10	311424.DhcVS_386	5.864e-84	285.0	COG0217@1|root,COG0217@2|Bacteria,2G6AI@200795|Chloroflexi,34CQY@301297|Dehalococcoidia	301297|Dehalococcoidia	K	regulation of RNA biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
PYH3_k127_2937254_20	255470.cbdbA399	4.154e-46	171.0	COG0817@1|root,COG0817@2|Bacteria,2G6MA@200795|Chloroflexi,34CPB@301297|Dehalococcoidia	301297|Dehalococcoidia	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group	ruvC	-	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
PYH3_k127_2937254_17	311424.DhcVS_384	5.756e-50	184.0	COG0632@1|root,COG0632@2|Bacteria,2G6V7@200795|Chloroflexi,34DA8@301297|Dehalococcoidia	301297|Dehalococcoidia	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB	ruvA	-	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
PYH3_k127_2937254_19	255470.cbdbA1172	8.624e-47	174.0	COG0655@1|root,COG0655@2|Bacteria,2G9U1@200795|Chloroflexi,34CYE@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Flavodoxin-like fold	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
PYH3_k127_2937254_25	1136417.AZWE01000053_gene3988	3.529e-12	68.0	COG0789@1|root,COG4978@1|root,COG0789@2|Bacteria,COG4978@2|Bacteria,2GMG7@201174|Actinobacteria,4DDUD@85008|Micromonosporales	201174|Actinobacteria	K	helix_turn_helix, mercury resistance	-	-	-	-	-	-	-	-	-	-	-	-	GyrI-like,MerR,MerR_1
PYH3_k127_2937254_16	706587.Desti_5196	3.075e-53	204.0	COG2271@1|root,COG2271@2|Bacteria,1QTW2@1224|Proteobacteria	1224|Proteobacteria	G	Major facilitator Superfamily	MA20_02120	-	-	-	-	-	-	-	-	-	-	-	MFS_1
PYH3_k127_2937254_6	255470.cbdbA973	6.258e-100	340.0	COG0477@1|root,COG2814@2|Bacteria,2G9WN@200795|Chloroflexi,34DKS@301297|Dehalococcoidia	301297|Dehalococcoidia	EGP	LacY proton/sugar symporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
PYH3_k127_2937254_4	2325.TKV_c18760	1.029e-104	365.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,247V1@186801|Clostridia,42EQG@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM NADH flavin oxidoreductase NADH oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN,Pyr_redox_2
PYH3_k127_2937254_12	439235.Dalk_3097	2.146e-72	254.0	COG1250@1|root,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,42M6J@68525|delta/epsilon subdivisions,2WJZQ@28221|Deltaproteobacteria,2MINF@213118|Desulfobacterales	28221|Deltaproteobacteria	I	PFAM 3-hydroxyacyl-CoA dehydrogenase domain protein	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
PYH3_k127_2937254_22	1144310.PMI07_006459	4.789e-36	148.0	COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,2TU6H@28211|Alphaproteobacteria,4BFWK@82115|Rhizobiaceae	28211|Alphaproteobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.17	ko:K01692,ko:K01715	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01200,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
PYH3_k127_2937254_3	255470.cbdbA1254	2.4e-142	459.0	COG1180@1|root,COG1180@2|Bacteria,2G6B2@200795|Chloroflexi,34D83@301297|Dehalococcoidia	301297|Dehalococcoidia	C	Radical SAM superfamily	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
PYH3_k127_2937254_7	552811.Dehly_0349	7.474e-89	300.0	COG1355@1|root,COG2078@1|root,COG1355@2|Bacteria,COG2078@2|Bacteria,2G6V0@200795|Chloroflexi,34CZ7@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Memo-like protein	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	AMMECR1,Memo
PYH3_k127_2937254_15	552811.Dehly_0349	9.997e-56	199.0	COG1355@1|root,COG2078@1|root,COG1355@2|Bacteria,COG2078@2|Bacteria,2G6V0@200795|Chloroflexi,34CZ7@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Memo-like protein	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	AMMECR1,Memo
PYH3_k127_2937254_13	926569.ANT_26620	1.661e-68	237.0	COG0778@1|root,COG0778@2|Bacteria	2|Bacteria	C	coenzyme F420-1:gamma-L-glutamate ligase activity	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
PYH3_k127_2937254_2	552811.Dehly_0351	1.16e-174	559.0	COG2256@1|root,COG2256@2|Bacteria,2G5JC@200795|Chloroflexi,34CVS@301297|Dehalococcoidia	301297|Dehalococcoidia	L	MgsA AAA+ ATPase C terminal	-	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA_assoc_2,MgsA_C,RuvB_N
PYH3_k127_2937254_18	1121430.JMLG01000026_gene2	3.817e-47	179.0	COG2945@1|root,COG2945@2|Bacteria	2|Bacteria	-	-	QU41_16170	-	-	ko:K07018	-	-	-	-	ko00000	-	-	-	Abhydrolase_1,Hydrolase_4,Peptidase_S15
PYH3_k127_2937254_24	596327.PORUE0001_1414	5.793e-22	100.0	COG0346@1|root,COG0346@2|Bacteria,4NNGG@976|Bacteroidetes,2FRZS@200643|Bacteroidia,22XX8@171551|Porphyromonadaceae	976|Bacteroidetes	E	methylmalonyl-CoA epimerase	mce	-	5.1.99.1	ko:K05606	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R02765,R09979	RC00780,RC02739	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase_4
PYH3_k127_2937254_9	255470.cbdbA647	2.608e-85	288.0	COG2197@1|root,COG2197@2|Bacteria,2G6T1@200795|Chloroflexi,34CJY@301297|Dehalococcoidia	301297|Dehalococcoidia	K	Bacterial regulatory proteins, luxR family	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
PYH3_k127_2937254_5	555088.DealDRAFT_1801	2.5e-100	351.0	COG4585@1|root,COG4585@2|Bacteria,1TQI3@1239|Firmicutes,249R9@186801|Clostridia	186801|Clostridia	T	Histidine kinase	-	-	2.7.13.3	ko:K07777	ko02020,map02020	M00478	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA_3,PAS
PYH3_k127_2937254_1	555088.DealDRAFT_1878	6.158e-268	843.0	COG0365@1|root,COG0365@2|Bacteria,1TQTI@1239|Firmicutes	1239|Firmicutes	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
PYH3_k127_2957117_2	710685.MycrhN_1153	1.872e-86	299.0	COG1804@1|root,COG1804@2|Bacteria,2GRB0@201174|Actinobacteria,232P8@1762|Mycobacteriaceae	201174|Actinobacteria	C	carnitine dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
PYH3_k127_2957117_3	1280946.HY29_13350	7.952e-06	49.0	COG2272@1|root,COG2272@2|Bacteria,1MVQZ@1224|Proteobacteria,2TTHT@28211|Alphaproteobacteria,43ZKE@69657|Hyphomonadaceae	28211|Alphaproteobacteria	I	Carboxylesterase family	-	-	-	ko:K03929	-	-	-	-	ko00000,ko01000	-	CE10	-	COesterase
PYH3_k127_2957117_4	1460635.JCM19038_1044	9.185e-06	54.0	COG0454@1|root,COG0454@2|Bacteria,1V78S@1239|Firmicutes,4HJMM@91061|Bacilli	91061|Bacilli	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
PYH3_k127_2957117_1	311424.DhcVS_1517	2.356e-137	449.0	COG3635@1|root,COG3635@2|Bacteria,2GAQC@200795|Chloroflexi,34D2I@301297|Dehalococcoidia	301297|Dehalococcoidia	G	Metalloenzyme superfamily	-	-	5.4.2.12	ko:K15635	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,PhosphMutase
PYH3_k127_2957117_0	311424.DhcVS_1515	9.216e-169	538.0	COG0527@1|root,COG0527@2|Bacteria,2G5U9@200795|Chloroflexi,34CW8@301297|Dehalococcoidia	301297|Dehalococcoidia	E	ACT domain	metL	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT
PYH3_k127_3010453_1	646529.Desaci_0702	3.708e-33	131.0	COG0183@1|root,COG0183@2|Bacteria,1TP07@1239|Firmicutes,2482I@186801|Clostridia,26019@186807|Peptococcaceae	186801|Clostridia	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
PYH3_k127_3010453_0	1415166.NONO_c50420	1.377e-37	144.0	COG2272@1|root,COG2272@2|Bacteria,2GJCN@201174|Actinobacteria,4G5Z2@85025|Nocardiaceae	201174|Actinobacteria	I	Carboxylesterase family	-	-	-	ko:K03929	-	-	-	-	ko00000,ko01000	-	CE10	-	COesterase
PYH3_k127_3015172_0	530564.Psta_4082	1.283e-84	308.0	COG3209@1|root,COG4932@1|root,COG3209@2|Bacteria,COG4932@2|Bacteria,2IYH3@203682|Planctomycetes	203682|Planctomycetes	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Dockerin_1,SdrD_B
PYH3_k127_3015172_2	1121468.AUBR01000056_gene1498	1.088e-63	231.0	COG1404@1|root,COG1404@2|Bacteria,1TQ2M@1239|Firmicutes,24CD5@186801|Clostridia,42G7V@68295|Thermoanaerobacterales	186801|Clostridia	O	PFAM peptidase S8 and S53, subtilisin, kexin, sedolisin	-	-	-	ko:K13274,ko:K14645	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	Big_2,CW_binding_2,Peptidase_S8,SLH
PYH3_k127_3015172_1	102125.Xen7305DRAFT_00020850	5.394e-74	259.0	COG3823@1|root,COG3823@2|Bacteria,1GPV5@1117|Cyanobacteria,3VMFK@52604|Pleurocapsales	1117|Cyanobacteria	O	Glutamine cyclotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Glu_cyclase_2
PYH3_k127_3015172_3	755732.Fluta_1564	3.291e-06	59.0	2DKFZ@1|root,309D6@2|Bacteria,4PK7J@976|Bacteroidetes,1IFCY@117743|Flavobacteriia,2PB0S@246874|Cryomorphaceae	976|Bacteroidetes	S	Domain of unknown function (DUF4382)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4382
PYH3_k127_3032278_2	311424.DhcVS_811	2.533e-141	457.0	COG1541@1|root,COG1541@2|Bacteria,2G695@200795|Chloroflexi,34CY3@301297|Dehalococcoidia	301297|Dehalococcoidia	H	AMP-binding enzyme	-	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding
PYH3_k127_3032278_3	255470.cbdbA895	4.693e-128	413.0	COG0410@1|root,COG0410@2|Bacteria,2G654@200795|Chloroflexi,34D18@301297|Dehalococcoidia	301297|Dehalococcoidia	E	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
PYH3_k127_3032278_5	311424.DhcVS_814	2.83e-116	387.0	COG0683@1|root,COG0683@2|Bacteria,2G9CJ@200795|Chloroflexi,34CJA@301297|Dehalococcoidia	301297|Dehalococcoidia	E	Periplasmic binding protein	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
PYH3_k127_3032278_1	311424.DhcVS_815	1.97e-145	468.0	COG4177@1|root,COG4177@2|Bacteria,2G6HP@200795|Chloroflexi,34D26@301297|Dehalococcoidia	301297|Dehalococcoidia	P	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
PYH3_k127_3032278_4	243164.DET0945	3.039e-123	402.0	COG0559@1|root,COG0559@2|Bacteria,2G6M5@200795|Chloroflexi,34D46@301297|Dehalococcoidia	301297|Dehalococcoidia	P	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
PYH3_k127_3032278_0	243164.DET0946	6.491e-293	911.0	COG1022@1|root,COG1022@2|Bacteria,2G5S9@200795|Chloroflexi,34D3Q@301297|Dehalococcoidia	301297|Dehalococcoidia	I	AMP-binding enzyme	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
PYH3_k127_3032278_9	1429916.X566_15995	7.258e-57	208.0	COG1024@1|root,COG1024@2|Bacteria,1R3U7@1224|Proteobacteria,2TV9G@28211|Alphaproteobacteria,3JU2F@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
PYH3_k127_3032278_8	1089553.Tph_c28000	7.954e-67	244.0	COG0407@1|root,COG0407@2|Bacteria,1TPQ6@1239|Firmicutes,25DH9@186801|Clostridia	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
PYH3_k127_3032278_6	1229780.BN381_210093	1.524e-83	291.0	COG1960@1|root,COG1960@2|Bacteria,2GKVN@201174|Actinobacteria,3UXCB@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	I	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
PYH3_k127_3032278_7	555793.WSK_3610	1.795e-76	272.0	COG1960@1|root,COG1960@2|Bacteria,1MVJC@1224|Proteobacteria,2TTRD@28211|Alphaproteobacteria,2K4UJ@204457|Sphingomonadales	204457|Sphingomonadales	C	overlaps another CDS with the same product name	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
PYH3_k127_3032278_10	1273538.G159_05065	5.254e-41	156.0	COG4799@1|root,COG4799@2|Bacteria,1TQCV@1239|Firmicutes,4HC50@91061|Bacilli,26D9G@186818|Planococcaceae	91061|Bacilli	I	COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)	-	-	-	-	-	-	-	-	-	-	-	-	Carboxyl_trans
PYH3_k127_3184326_0	720554.Clocl_2080	1.499e-111	369.0	COG1712@1|root,COG1712@2|Bacteria,1TQ4R@1239|Firmicutes,2499V@186801|Clostridia,3WGPW@541000|Ruminococcaceae	186801|Clostridia	E	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate	ddh	-	1.4.1.16	ko:K03340	ko00300,ko01100,ko01110,ko01230,map00300,map01100,map01110,map01230	M00526	R02755	RC00006	ko00000,ko00001,ko00002,ko01000	-	-	-	DAPDH_C,DapB_N
PYH3_k127_3184326_3	552811.Dehly_0242	1.89e-38	147.0	2E4R1@1|root,32ZJK@2|Bacteria,2G9B6@200795|Chloroflexi	200795|Chloroflexi	S	Nitrous oxide-stimulated promoter	-	-	-	-	-	-	-	-	-	-	-	-	YgbA_NO
PYH3_k127_3184326_1	552811.Dehly_0601	7.674e-69	247.0	COG0628@1|root,COG0628@2|Bacteria,2G712@200795|Chloroflexi	200795|Chloroflexi	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
PYH3_k127_3184326_4	118166.JH976537_gene1719	1.362e-22	101.0	COG0745@1|root,COG0745@2|Bacteria,1G0YA@1117|Cyanobacteria,1H7GK@1150|Oscillatoriales	1117|Cyanobacteria	T	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	rpaB	-	-	ko:K11329	ko02020,map02020	M00467	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
PYH3_k127_3184326_2	909663.KI867150_gene323	1.11e-64	232.0	COG0299@1|root,COG0299@2|Bacteria	2|Bacteria	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	-	-	2.1.2.2,6.2.1.13	ko:K01905,ko:K11175,ko:K22224	ko00010,ko00230,ko00620,ko00640,ko00670,ko01100,ko01110,ko01120,ko01130,map00010,map00230,map00620,map00640,map00670,map01100,map01110,map01120,map01130	M00048	R00229,R00920,R04325,R04326	RC00004,RC00012,RC00014,RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Formyl_trans_N
PYH3_k127_3271540_8	552811.Dehly_0012	3.664e-46	173.0	COG0344@1|root,COG0344@2|Bacteria,2G6U5@200795|Chloroflexi,34CTI@301297|Dehalococcoidia	301297|Dehalococcoidia	I	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP	-	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
PYH3_k127_3271540_6	255470.cbdbA1704	3.654e-88	300.0	COG0613@1|root,COG0613@2|Bacteria,2G6H4@200795|Chloroflexi,34CSU@301297|Dehalococcoidia	301297|Dehalococcoidia	S	DNA polymerase alpha chain like domain	-	-	3.1.3.97	ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	PHP
PYH3_k127_3271540_3	552811.Dehly_0010	5.79e-94	315.0	COG1692@1|root,COG1692@2|Bacteria,2GAP9@200795|Chloroflexi,34CYI@301297|Dehalococcoidia	301297|Dehalococcoidia	S	YmdB-like protein	-	-	-	ko:K09769	-	-	-	-	ko00000	-	-	-	YmdB
PYH3_k127_3271540_1	311424.DhcVS_1490	1.137e-215	680.0	COG1418@1|root,COG4372@1|root,COG1418@2|Bacteria,COG4372@2|Bacteria,2G620@200795|Chloroflexi,34D54@301297|Dehalococcoidia	301297|Dehalococcoidia	A	Endoribonuclease that initiates mRNA decay	rny	-	-	ko:K18682	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DUF3552,HD,KH_1
PYH3_k127_3271540_7	311424.DhcVS_1489	3.498e-49	182.0	COG2137@1|root,COG2137@2|Bacteria,2G6WA@200795|Chloroflexi,34D0G@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Modulates RecA activity	recX	-	-	ko:K03565	-	-	-	-	ko00000,ko03400	-	-	-	RecX
PYH3_k127_3271540_2	255470.cbdbA1700	6.287e-143	460.0	COG0468@1|root,COG0468@2|Bacteria,2G5WE@200795|Chloroflexi,34D29@301297|Dehalococcoidia	301297|Dehalococcoidia	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	-	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
PYH3_k127_3271540_5	243164.DET0389	1.002e-90	308.0	COG0142@1|root,COG0142@2|Bacteria,2G6IZ@200795|Chloroflexi,34CSE@301297|Dehalococcoidia	301297|Dehalococcoidia	H	Polyprenyl synthetase	hepT	-	2.5.1.30,2.5.1.90	ko:K00805,ko:K02523	ko00900,ko01110,map00900,map01110	-	R09247,R09248	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
PYH3_k127_3271540_0	552811.Dehly_1271	3.269e-245	768.0	COG0143@1|root,COG0143@2|Bacteria,2G5ZU@200795|Chloroflexi,34D7N@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1g
PYH3_k127_3271540_9	552811.Dehly_1270	6.298e-16	81.0	2BPGZ@1|root,32I9C@2|Bacteria,2G9VY@200795|Chloroflexi,34DH4@301297|Dehalococcoidia	301297|Dehalococcoidia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_3271540_4	552811.Dehly_1269	1.897e-91	308.0	COG0313@1|root,COG0313@2|Bacteria,2G6E3@200795|Chloroflexi,34CPU@301297|Dehalococcoidia	301297|Dehalococcoidia	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	-	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
PYH3_k127_3299539_17	439235.Dalk_3257	4.072e-58	209.0	COG0778@1|root,COG0778@2|Bacteria,1MWMJ@1224|Proteobacteria,42R9J@68525|delta/epsilon subdivisions,2WN13@28221|Deltaproteobacteria,2MJNG@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
PYH3_k127_3299539_13	335543.Sfum_2526	7.084e-83	286.0	COG1163@1|root,COG1163@2|Bacteria,1RFPD@1224|Proteobacteria,42ZF3@68525|delta/epsilon subdivisions,2WUZY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	TGS domain	-	-	-	ko:K06944	-	-	-	-	ko00000	-	-	-	MMR_HSR1,TGS
PYH3_k127_3299539_2	243164.DET1216	1.485e-191	616.0	COG0322@1|root,COG0322@2|Bacteria,2G651@200795|Chloroflexi,34CKY@301297|Dehalococcoidia	301297|Dehalococcoidia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,UVR,UvrC_HhH_N
PYH3_k127_3299539_1	552811.Dehly_1439	4.746e-198	624.0	COG1158@1|root,COG1158@2|Bacteria,2G5UQ@200795|Chloroflexi,34DA2@301297|Dehalococcoidia	301297|Dehalococcoidia	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
PYH3_k127_3299539_12	311424.DhcVS_1190	2.113e-85	287.0	COG0176@1|root,COG0176@2|Bacteria,2G6T8@200795|Chloroflexi,34D7M@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
PYH3_k127_3299539_18	398512.JQKC01000037_gene4519	3.909e-47	178.0	COG1011@1|root,COG1011@2|Bacteria,1V3WC@1239|Firmicutes,24J13@186801|Clostridia	186801|Clostridia	S	HAD hydrolase, family IA, variant 1	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
PYH3_k127_3299539_0	255470.cbdbA1371	1.068e-260	812.0	COG0504@1|root,COG0504@2|Bacteria,2G5U0@200795|Chloroflexi,34CRC@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
PYH3_k127_3299539_19	589924.Ferp_2206	6.556e-40	156.0	COG5423@1|root,arCOG04361@2157|Archaea,2Y00P@28890|Euryarchaeota	28890|Euryarchaeota	S	Predicted metal-binding protein (DUF2284)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2284
PYH3_k127_3299539_3	255470.cbdbA508	3.861e-160	516.0	COG0019@1|root,COG0019@2|Bacteria,2G5RR@200795|Chloroflexi,34CN6@301297|Dehalococcoidia	301297|Dehalococcoidia	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
PYH3_k127_3299539_16	311424.DhcVS_476	9.953e-68	243.0	COG2812@1|root,COG2812@2|Bacteria,2G6K3@200795|Chloroflexi,34CM2@301297|Dehalococcoidia	301297|Dehalococcoidia	L	DNA polymerase III, delta subunit	holB	-	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNApol3-delta_C
PYH3_k127_3299539_11	243164.DET0536	6.252e-93	314.0	COG1774@1|root,COG1774@2|Bacteria,2G6AJ@200795|Chloroflexi,34D5Z@301297|Dehalococcoidia	301297|Dehalococcoidia	S	PSP1 C-terminal conserved region	-	-	-	-	-	-	-	-	-	-	-	-	PSP1
PYH3_k127_3299539_8	311424.DhcVS_1404	3.338e-105	349.0	COG1600@1|root,COG1600@2|Bacteria,2GBWF@200795|Chloroflexi,34DPF@301297|Dehalococcoidia	301297|Dehalococcoidia	C	4Fe-4S double cluster binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_16
PYH3_k127_3299539_14	255470.cbdbA371	5.27e-80	274.0	COG0834@1|root,COG0834@2|Bacteria,2G7BD@200795|Chloroflexi,34CRW@301297|Dehalococcoidia	301297|Dehalococcoidia	ET	Bacterial periplasmic substrate-binding proteins	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
PYH3_k127_3299539_5	552811.Dehly_0402	6.762e-112	367.0	COG0765@1|root,COG0765@2|Bacteria,2G6IJ@200795|Chloroflexi,34D73@301297|Dehalococcoidia	301297|Dehalococcoidia	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02029	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	BPD_transp_1
PYH3_k127_3299539_4	552811.Dehly_0403	6.892e-119	386.0	COG1126@1|root,COG1126@2|Bacteria,2G5UB@200795|Chloroflexi,34CW1@301297|Dehalococcoidia	301297|Dehalococcoidia	E	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	3.6.3.21	ko:K02028	-	M00236	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.3	-	-	ABC_tran
PYH3_k127_3299539_10	768706.Desor_2987	9.207e-94	320.0	COG0183@1|root,COG0183@2|Bacteria,1TT8U@1239|Firmicutes,24FFI@186801|Clostridia,263WE@186807|Peptococcaceae	186801|Clostridia	I	PFAM Thiolase, C-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
PYH3_k127_3299539_22	267377.MMP1213	4.311e-17	93.0	COG1545@1|root,arCOG01285@2157|Archaea,2XXGF@28890|Euryarchaeota,23QWX@183939|Methanococci	183939|Methanococci	V	DUF35 OB-fold domain, acyl-CoA-associated	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
PYH3_k127_3299539_15	264198.Reut_C6079	2.687e-72	260.0	COG2015@1|root,COG2015@2|Bacteria,1R9IE@1224|Proteobacteria,2VKAR@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	Alkyl sulfatase and related hydrolases	-	-	-	-	-	-	-	-	-	-	-	-	Alkyl_sulf_dimr,Lactamase_B
PYH3_k127_3299539_9	909663.KI867150_gene1369	5.149e-105	359.0	COG4262@1|root,COG4262@2|Bacteria,1QUK8@1224|Proteobacteria,42SZH@68525|delta/epsilon subdivisions,2WPX7@28221|Deltaproteobacteria,2MQHU@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	-	-	-	-	-	-	-	-	-	-	-	-	Spermine_synth
PYH3_k127_3299539_6	880073.Calab_0498	1.412e-109	363.0	COG0332@1|root,COG0332@2|Bacteria,2NQDW@2323|unclassified Bacteria	2|Bacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180,2.3.1.262	ko:K00648,ko:K18003	ko00061,ko00405,ko01100,ko01130,ko01212,ko02024,ko02025,map00061,map00405,map01100,map01130,map01212,map02024,map02025	M00082,M00083	R10707,R11586,R11587,R11588	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
PYH3_k127_3299539_20	521011.Mpal_0675	1.527e-27	117.0	COG2133@1|root,arCOG03441@1|root,arCOG02796@2157|Archaea,arCOG03441@2157|Archaea,2XT1Q@28890|Euryarchaeota	28890|Euryarchaeota	G	COG2133 Glucose sorbosone dehydrogenases	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1,GSDH
PYH3_k127_3299539_7	660470.Theba_0067	2.522e-105	352.0	COG0407@1|root,COG0407@2|Bacteria	2|Bacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
PYH3_k127_3299539_23	661478.OP10G_2274	0.0002895	52.0	COG1470@1|root,COG1470@2|Bacteria	2|Bacteria	S	cell adhesion involved in biofilm formation	-	-	-	-	-	-	-	-	-	-	-	-	ChW,DUF3048,DUF3048_C,RicinB_lectin_2,Ricin_B_lectin
PYH3_k127_3299539_21	1227453.C444_19652	1.047e-20	102.0	COG0500@1|root,arCOG01773@2157|Archaea	2157|Archaea	Q	Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
PYH3_k127_3441817_3	760568.Desku_2605	1.13e-26	111.0	COG4799@1|root,COG4799@2|Bacteria,1TQCV@1239|Firmicutes,247WG@186801|Clostridia,25ZXW@186807|Peptococcaceae	186801|Clostridia	I	acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)	-	-	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
PYH3_k127_3441817_0	552811.Dehly_1025	3.717e-134	434.0	COG0180@1|root,COG0180@2|Bacteria,2G6CG@200795|Chloroflexi,34CX6@301297|Dehalococcoidia	301297|Dehalococcoidia	J	tRNA synthetases class I (W and Y)	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
PYH3_k127_3441817_2	585529.HMPREF0291_10513	2.542e-37	146.0	COG0663@1|root,COG0663@2|Bacteria,2GP22@201174|Actinobacteria,22MWU@1653|Corynebacteriaceae	201174|Actinobacteria	S	Carbonic anhydrases acetyltransferases, isoleucine patch superfamily	gca	GO:0003674,GO:0003824,GO:0004089,GO:0005488,GO:0008270,GO:0016829,GO:0016835,GO:0016836,GO:0043167,GO:0043168,GO:0043169,GO:0043199,GO:0046872,GO:0046914,GO:0050897,GO:0071890,GO:1901681	-	ko:K02617	-	-	-	-	ko00000	-	-	-	Hexapep
PYH3_k127_3441817_4	1305737.JAFX01000001_gene442	6.72e-13	73.0	COG2314@1|root,COG2314@2|Bacteria,4NU6E@976|Bacteroidetes,47UUI@768503|Cytophagia	976|Bacteroidetes	S	TM2 domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4178,TM2
PYH3_k127_3441817_1	243164.DET1270	4.869e-102	336.0	COG0018@1|root,COG0018@2|Bacteria,2G6DK@200795|Chloroflexi,34CN0@301297|Dehalococcoidia	301297|Dehalococcoidia	J	arginyl-tRNA aminoacylation	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
PYH3_k127_348066_5	1101188.KI912155_gene2983	1.839e-49	183.0	COG1804@1|root,COG1804@2|Bacteria,2IB9E@201174|Actinobacteria	201174|Actinobacteria	C	L-carnitine dehydratase bile acid-inducible protein F	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
PYH3_k127_348066_3	552811.Dehly_1326	7.644e-70	247.0	COG1073@1|root,COG1073@2|Bacteria	2|Bacteria	S	thiolester hydrolase activity	luxD	-	3.2.1.4,4.2.99.18	ko:K01179,ko:K06889,ko:K10773,ko:K15853	ko00500,ko01100,ko02020,ko02024,ko03410,map00500,map01100,map02020,map02024,map03410	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000,ko03400	-	GH5,GH9	-	Abhydrolase_1,Acyl_transf_2,DLH,DUF2048,Hydrolase_4,Peptidase_S9
PYH3_k127_348066_1	1220589.CD32_05170	2.215e-75	260.0	COG0566@1|root,COG0566@2|Bacteria,1TP9G@1239|Firmicutes,4HBBI@91061|Bacilli,3IW20@400634|Lysinibacillus	91061|Bacilli	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	trmH	GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070039,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.185	ko:K03218	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SpoU_methylase,SpoU_sub_bind
PYH3_k127_348066_6	903818.KI912269_gene180	1.657e-36	147.0	28K30@1|root,3359X@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_348066_4	439235.Dalk_3875	1.579e-56	211.0	COG0778@1|root,COG1145@1|root,COG0778@2|Bacteria,COG1145@2|Bacteria,1PE5U@1224|Proteobacteria,42VB3@68525|delta/epsilon subdivisions,2WS8C@28221|Deltaproteobacteria,2MN7P@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Nitroreductase
PYH3_k127_348066_2	671143.DAMO_0597	2.952e-70	246.0	COG2057@1|root,COG2057@2|Bacteria,2NP63@2323|unclassified Bacteria	2|Bacteria	I	Coenzyme A transferase	-	-	2.8.3.12	ko:K01040	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
PYH3_k127_348066_0	671143.DAMO_0596	2.386e-76	262.0	COG1788@1|root,COG1788@2|Bacteria,2NR4U@2323|unclassified Bacteria	2|Bacteria	I	Coenzyme A transferase	-	-	2.8.3.12	ko:K01039	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
PYH3_k127_3638554_0	880072.Desac_0822	1.71e-260	823.0	COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_20,Pyr_redox_2
PYH3_k127_3638554_2	1125863.JAFN01000001_gene1551	5.414e-24	102.0	COG1908@1|root,COG1908@2|Bacteria,1RCZY@1224|Proteobacteria,42T3M@68525|delta/epsilon subdivisions,2WPVI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Methyl-viologen-reducing hydrogenase, delta subunit	-	-	-	-	-	-	-	-	-	-	-	-	FlpD
PYH3_k127_3638554_3	1121423.JONT01000002_gene2232	1.277e-17	84.0	COG1908@1|root,COG1908@2|Bacteria,1V638@1239|Firmicutes,24J0E@186801|Clostridia,261V3@186807|Peptococcaceae	186801|Clostridia	C	PFAM methyl-viologen-reducing hydrogenase delta subunit	-	-	-	-	-	-	-	-	-	-	-	-	FlpD
PYH3_k127_3638554_1	933262.AXAM01000041_gene1905	8.462e-69	238.0	COG4656@1|root,COG4656@2|Bacteria,1MWAX@1224|Proteobacteria,42NJM@68525|delta/epsilon subdivisions,2WKM6@28221|Deltaproteobacteria,2MIVI@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Methylene-tetrahydrofolate reductase C terminal	-	-	-	-	-	-	-	-	-	-	-	-	MTHFR_C
PYH3_k127_3661322_4	635013.TherJR_1012	9.706e-87	297.0	COG4277@1|root,COG4277@2|Bacteria,1TRT2@1239|Firmicutes,247UD@186801|Clostridia,261DR@186807|Peptococcaceae	186801|Clostridia	S	DNA modification repair radical SAM protein	-	-	-	-	-	-	-	-	-	-	-	-	HHH_3,Radical_SAM
PYH3_k127_3661322_7	1267533.KB906737_gene1695	3.764e-27	115.0	COG5580@1|root,COG5580@2|Bacteria,3Y90D@57723|Acidobacteria,2JNT0@204432|Acidobacteriia	204432|Acidobacteriia	O	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
PYH3_k127_3661322_3	555793.WSK_3610	5.797e-93	320.0	COG1960@1|root,COG1960@2|Bacteria,1MVJC@1224|Proteobacteria,2TTRD@28211|Alphaproteobacteria,2K4UJ@204457|Sphingomonadales	204457|Sphingomonadales	C	overlaps another CDS with the same product name	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
PYH3_k127_3661322_5	1229780.BN381_210093	1.497e-86	300.0	COG1960@1|root,COG1960@2|Bacteria,2GKVN@201174|Actinobacteria,3UXCB@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	I	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
PYH3_k127_3661322_1	765420.OSCT_0589	6.142e-135	436.0	COG4608@1|root,COG4608@2|Bacteria,2G5R5@200795|Chloroflexi,3754I@32061|Chloroflexia	32061|Chloroflexia	P	TIGRFAM oligopeptide dipeptide ABC transporter, ATPase subunit	-	-	-	ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
PYH3_k127_3661322_0	311424.DhcVS_929	1.394e-144	466.0	COG0444@1|root,COG0444@2|Bacteria,2G61B@200795|Chloroflexi,34DJW@301297|Dehalococcoidia	301297|Dehalococcoidia	P	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
PYH3_k127_3661322_2	255470.cbdbA1037	1.446e-132	428.0	COG1173@1|root,COG1173@2|Bacteria,2G9WH@200795|Chloroflexi,34DKE@301297|Dehalococcoidia	301297|Dehalococcoidia	EP	N-terminal TM domain of oligopeptide transport permease C	-	-	-	ko:K15582	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1,OppC_N
PYH3_k127_3661322_6	311424.DhcVS_931	2.119e-35	136.0	COG0601@1|root,COG0601@2|Bacteria,2G9WT@200795|Chloroflexi,34DMG@301297|Dehalococcoidia	301297|Dehalococcoidia	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K15581	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1
PYH3_k127_3683938_0	383372.Rcas_2730	3.473e-128	450.0	COG0457@1|root,COG2114@1|root,COG3899@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG3899@2|Bacteria,2G699@200795|Chloroflexi,3764S@32061|Chloroflexia	32061|Chloroflexia	T	PFAM adenylyl cyclase class-3 4 guanylyl cyclase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Guanylate_cyc,TPR_12
PYH3_k127_3683938_4	311424.DhcVS_367	5.513e-47	179.0	COG1235@1|root,COG1235@2|Bacteria,2GBG8@200795|Chloroflexi,34CTS@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
PYH3_k127_3683938_3	1162668.LFE_1912	6.268e-63	232.0	COG1252@1|root,COG1252@2|Bacteria,3J12C@40117|Nitrospirae	40117|Nitrospirae	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
PYH3_k127_3683938_1	1168034.FH5T_19015	5.198e-110	377.0	COG0644@1|root,COG0644@2|Bacteria,4P040@976|Bacteroidetes	976|Bacteroidetes	C	oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_3683938_6	1121875.KB907548_gene1637	8.918e-19	101.0	COG0664@1|root,COG0664@2|Bacteria,4NRPE@976|Bacteroidetes	976|Bacteroidetes	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
PYH3_k127_3683938_5	311424.DhcVS_119	3.417e-33	135.0	COG0680@1|root,COG0680@2|Bacteria,2G7BV@200795|Chloroflexi,34D7G@301297|Dehalococcoidia	301297|Dehalococcoidia	C	Hydrogenase maturation protease	-	-	-	ko:K03605	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	HycI
PYH3_k127_3683938_2	243164.DET0110	2.669e-75	255.0	COG0374@1|root,COG0374@2|Bacteria,2G6SF@200795|Chloroflexi,34CJW@301297|Dehalococcoidia	301297|Dehalococcoidia	C	hydrogenase large subunit	hupL	-	1.12.99.6	ko:K06281	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
PYH3_k127_3684402_4	456442.Mboo_0798	2.955e-11	70.0	COG3187@1|root,arCOG03952@2157|Archaea,2Y55P@28890|Euryarchaeota,2NBFA@224756|Methanomicrobia	224756|Methanomicrobia	O	META domain	-	-	-	-	-	-	-	-	-	-	-	-	META
PYH3_k127_3684402_1	243164.DET0937	2.068e-35	139.0	COG2050@1|root,COG2050@2|Bacteria,2G9P8@200795|Chloroflexi,34DBN@301297|Dehalococcoidia	301297|Dehalococcoidia	Q	Thioesterase superfamily	-	-	-	ko:K02614	ko00360,map00360	-	R09840	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	4HBT
PYH3_k127_3684402_2	552811.Dehly_0955	3.427e-29	127.0	COG1633@1|root,COG1633@2|Bacteria	2|Bacteria	S	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
PYH3_k127_3684402_0	909663.KI867150_gene854	1.958e-94	314.0	COG1773@1|root,COG1853@1|root,COG1773@2|Bacteria,COG1853@2|Bacteria,1N731@1224|Proteobacteria,42VC4@68525|delta/epsilon subdivisions,2WRDM@28221|Deltaproteobacteria,2MQMC@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Rubredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct,Rubredoxin
PYH3_k127_3684402_3	552811.Dehly_0133	2.057e-15	77.0	COG0379@1|root,COG0379@2|Bacteria,2G64Y@200795|Chloroflexi,34D8K@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	-	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	-	NadA
PYH3_k127_3711780_0	485913.Krac_11180	4.207e-38	158.0	COG5650@1|root,COG5650@2|Bacteria	2|Bacteria	M	phosphatidylinositol metabolic process	-	-	-	ko:K13671	-	-	-	-	ko00000,ko01000,ko01003	-	GT87	-	GT87
PYH3_k127_3711780_1	485913.Krac_3162	5.057e-29	128.0	COG1073@1|root,COG1073@2|Bacteria,2G8PF@200795|Chloroflexi	200795|Chloroflexi	S	X-Pro dipeptidyl-peptidase (S15 family)	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
PYH3_k127_3711780_3	1408424.JHYI01000023_gene4235	4.804e-07	57.0	2EGCD@1|root,33A46@2|Bacteria,1UMBP@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4190
PYH3_k127_3711780_2	552811.Dehly_1219	1.06e-08	61.0	COG0789@1|root,COG0789@2|Bacteria,2G9W3@200795|Chloroflexi,34DHG@301297|Dehalococcoidia	301297|Dehalococcoidia	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17
PYH3_k127_3798585_6	243164.DET1200	5.867e-70	245.0	COG0044@1|root,COG0044@2|Bacteria,2G640@200795|Chloroflexi,34CTM@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	pyrC	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
PYH3_k127_3798585_5	673860.AciM339_1448	1.711e-84	297.0	COG0540@1|root,arCOG00911@2157|Archaea,2XSZ7@28890|Euryarchaeota,3F2F5@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	PFAM aspartate ornithine carbamoyltransferase carbamoyl-P binding domain	pyrB	GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A1168	OTCace,OTCace_N
PYH3_k127_3798585_8	255470.cbdbA1112	8.681e-68	236.0	COG2065@1|root,COG2065@2|Bacteria,2G6WS@200795|Chloroflexi,34D9M@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant	pyrR	GO:0003674,GO:0003700,GO:0003824,GO:0004845,GO:0006139,GO:0006220,GO:0006221,GO:0006355,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019637,GO:0019693,GO:0031323,GO:0031326,GO:0034641,GO:0034654,GO:0043094,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0055086,GO:0060255,GO:0065007,GO:0071704,GO:0072527,GO:0072528,GO:0080090,GO:0090407,GO:0140110,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:2000112,GO:2001141	2.4.2.9	ko:K02825	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000,ko03000	-	-	-	Pribosyltran
PYH3_k127_3798585_12	255470.cbdbA1100	4.012e-26	109.0	COG0826@1|root,COG0826@2|Bacteria,2GAVB@200795|Chloroflexi,34DF3@301297|Dehalococcoidia	301297|Dehalococcoidia	O	peptidase U32	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_3798585_7	868595.Desca_1067	8.026e-68	235.0	COG0054@1|root,COG0054@2|Bacteria,1V1DA@1239|Firmicutes,24FRS@186801|Clostridia,261H1@186807|Peptococcaceae	186801|Clostridia	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	-	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
PYH3_k127_3798585_3	194439.CT1591	2.54e-163	523.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1FD5R@1090|Chlorobi	1090|Chlorobi	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribBA	-	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2
PYH3_k127_3798585_9	411473.RUMCAL_02721	6.862e-63	222.0	COG0307@1|root,COG0307@2|Bacteria,1V1EP@1239|Firmicutes,24FVK@186801|Clostridia,3WIGR@541000|Ruminococcaceae	186801|Clostridia	H	riboflavin synthase, alpha subunit	ribE	-	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	Lum_binding
PYH3_k127_3798585_4	311424.DhcVS_973	9.118e-137	444.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,2G5SW@200795|Chloroflexi,34CN3@301297|Dehalococcoidia	301297|Dehalococcoidia	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	ribD	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
PYH3_k127_3798585_10	867845.KI911784_gene246	1.886e-31	129.0	COG0589@1|root,COG0589@2|Bacteria	2|Bacteria	T	AMP binding	-	-	-	-	-	-	-	-	-	-	-	-	CBS,Usp
PYH3_k127_3798585_2	552811.Dehly_0563	6.356e-168	536.0	COG0426@1|root,COG0426@2|Bacteria,2G9HN@200795|Chloroflexi	200795|Chloroflexi	C	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_3798585_14	608538.HTH_0332	4.278e-21	98.0	COG0071@1|root,COG0071@2|Bacteria,2G4AZ@200783|Aquificae	200783|Aquificae	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
PYH3_k127_3798585_0	255470.cbdbA801	1.085e-197	627.0	COG1690@1|root,COG1690@2|Bacteria,2G5NT@200795|Chloroflexi,34D7J@301297|Dehalococcoidia	301297|Dehalococcoidia	S	tRNA-splicing ligase RtcB	rtcB	-	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
PYH3_k127_3798585_11	309799.DICTH_1160	1.374e-29	122.0	COG1371@1|root,COG1371@2|Bacteria	2|Bacteria	J	PFAM Archease protein family (DUF101 UPF0211)	-	-	-	-	-	-	-	-	-	-	-	-	Archease
PYH3_k127_3798585_13	309801.trd_1757	1.737e-25	108.0	COG0721@1|root,COG0721@2|Bacteria,2G763@200795|Chloroflexi,27YK5@189775|Thermomicrobia	189775|Thermomicrobia	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	-	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Glu-tRNAGln
PYH3_k127_3798585_1	552811.Dehly_1039	2.539e-186	591.0	COG0154@1|root,COG0154@2|Bacteria,2G5T0@200795|Chloroflexi,34CJK@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
PYH3_k127_3799557_3	1047013.AQSP01000084_gene758	1.797e-98	329.0	COG0543@1|root,COG0543@2|Bacteria,2NNUA@2323|unclassified Bacteria	2|Bacteria	CH	Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B	pyrK_1	-	1.18.1.2,1.19.1.1,1.4.1.13,1.4.1.14	ko:K00266,ko:K00528,ko:K02823	ko00240,ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00240,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248,R10159	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
PYH3_k127_3799557_1	386456.JQKN01000009_gene1131	1.967e-210	666.0	COG0243@1|root,arCOG01492@2157|Archaea,2Y8AB@28890|Euryarchaeota	28890|Euryarchaeota	C	formate dehydrogenase, alpha subunit	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Fer4,Fer4_21,Fer4_6,Fer4_7,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
PYH3_k127_3799557_2	760568.Desku_2988	4.782e-109	364.0	COG3383@1|root,COG3383@2|Bacteria,1UI1F@1239|Firmicutes,25EAG@186801|Clostridia,2607X@186807|Peptococcaceae	186801|Clostridia	C	Molybdopterin oxidoreductase Fe4S4 region	-	-	1.17.1.10,1.6.5.3	ko:K00336,ko:K05299	ko00190,ko00680,ko00720,ko01100,ko01120,ko01200,map00190,map00680,map00720,map01100,map01120,map01200	M00144,M00377	R00134,R11945	RC00061,RC02796	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Fer4,Fer4_6,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
PYH3_k127_3799557_0	1047013.AQSP01000091_gene642	4.285e-314	992.0	COG0493@1|root,COG1894@1|root,COG0493@2|Bacteria,COG1894@2|Bacteria,2NNM1@2323|unclassified Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	sfrB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0044237,GO:0044424,GO:0044464,GO:0045333,GO:0055114,GO:0071944	1.12.1.3,1.17.1.10,1.6.5.3	ko:K00335,ko:K15022,ko:K18331	ko00190,ko00680,ko00720,ko01100,ko01120,ko01200,map00190,map00680,map00720,map01100,map01120,map01200	M00144,M00377	R00134,R11945	RC00061,RC02796	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iAF987.Gmet_2080	2Fe-2S_thioredx,Complex1_51K,Fer4,Fer4_20,NADH_4Fe-4S,Pyr_redox_2,SLBB
PYH3_k127_3799557_6	891968.Anamo_1681	3.137e-45	168.0	COG1905@1|root,COG1905@2|Bacteria,3TAVA@508458|Synergistetes	508458|Synergistetes	C	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit	-	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
PYH3_k127_3799557_7	552811.Dehly_0084	1.503e-31	126.0	COG2052@1|root,COG2052@2|Bacteria,2GAV2@200795|Chloroflexi,34DEP@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Domain of unknown function (DUF370)	-	-	-	ko:K09777	-	-	-	-	ko00000	-	-	-	DUF370
PYH3_k127_3799557_5	243164.DET0035	4.659e-61	217.0	COG0194@1|root,COG0194@2|Bacteria,2G6EW@200795|Chloroflexi,34D78@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Essential for recycling GMP and indirectly, cGMP	gmk	-	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
PYH3_k127_3799557_4	439235.Dalk_1142	1.447e-92	321.0	COG1042@1|root,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,42KZW@68525|delta/epsilon subdivisions,2WIQB@28221|Deltaproteobacteria,2MIWX@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM CoA-binding domain protein	-	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
PYH3_k127_3856287_3	1122134.KB893650_gene1142	2.564e-05	52.0	COG0842@1|root,COG1511@1|root,COG0842@2|Bacteria,COG1511@2|Bacteria,1PM1H@1224|Proteobacteria,1RUN8@1236|Gammaproteobacteria,1XQN3@135619|Oceanospirillales	135619|Oceanospirillales	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
PYH3_k127_3856287_1	926569.ANT_08160	5.813e-18	96.0	COG0842@1|root,COG0842@2|Bacteria,2G774@200795|Chloroflexi	200795|Chloroflexi	V	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
PYH3_k127_3856287_0	350688.Clos_2585	4.204e-76	263.0	COG1131@1|root,COG1131@2|Bacteria,1TPMQ@1239|Firmicutes,248QD@186801|Clostridia,36DTX@31979|Clostridiaceae	186801|Clostridia	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
PYH3_k127_3856287_2	316274.Haur_4579	1.548e-17	86.0	COG1131@1|root,COG1131@2|Bacteria,2G5QI@200795|Chloroflexi,376R4@32061|Chloroflexia	32061|Chloroflexia	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
PYH3_k127_3921862_5	525904.Tter_2567	0.0005539	47.0	COG0589@1|root,COG0589@2|Bacteria,2NRGN@2323|unclassified Bacteria	2|Bacteria	T	PFAM UspA domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
PYH3_k127_3921862_3	255470.cbdbA832	2.762e-58	213.0	COG0340@1|root,COG0340@2|Bacteria,2G6WF@200795|Chloroflexi,34CYT@301297|Dehalococcoidia	301297|Dehalococcoidia	H	Biotin protein ligase C terminal domain	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB
PYH3_k127_3921862_2	643648.Slip_0187	3.637e-92	312.0	COG0330@1|root,COG0330@2|Bacteria,1TPXU@1239|Firmicutes,248MP@186801|Clostridia,42K01@68298|Syntrophomonadaceae	186801|Clostridia	O	SPFH domain Band 7 family	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
PYH3_k127_3921862_1	479434.Sthe_1855	1.705e-105	358.0	COG1030@1|root,COG1030@2|Bacteria,2G6E2@200795|Chloroflexi,27XU8@189775|Thermomicrobia	189775|Thermomicrobia	O	NfeD-like C-terminal, partner-binding	-	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	NfeD
PYH3_k127_3921862_0	383372.Rcas_0210	1.894e-121	397.0	COG0714@1|root,COG0714@2|Bacteria,2G66D@200795|Chloroflexi,374V5@32061|Chloroflexia	32061|Chloroflexia	S	ATPase associated with various cellular activities, AAA_5	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
PYH3_k127_3921862_4	316274.Haur_0623	1.008e-55	211.0	COG1721@1|root,COG1721@2|Bacteria,2G5XH@200795|Chloroflexi,374YS@32061|Chloroflexia	32061|Chloroflexia	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
PYH3_k127_3924602_19	247490.KSU1_C0202	8.987e-10	62.0	COG0330@1|root,COG0330@2|Bacteria	2|Bacteria	O	stress-induced mitochondrial fusion	hflC	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Band_7
PYH3_k127_3924602_11	1121468.AUBR01000023_gene2763	3.775e-68	246.0	COG0303@1|root,COG1910@1|root,COG0303@2|Bacteria,COG1910@2|Bacteria,1TRH3@1239|Firmicutes,24ATZ@186801|Clostridia,42FES@68295|Thermoanaerobacterales	186801|Clostridia	HP	TIGRFAM molybdenum cofactor synthesis	-	-	2.10.1.1	ko:K03750,ko:K07219	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N,PBP_like
PYH3_k127_3924602_9	368407.Memar_1892	5.768e-75	263.0	COG2998@1|root,arCOG00229@2157|Archaea,2XUR9@28890|Euryarchaeota,2N9NW@224756|Methanomicrobia	224756|Methanomicrobia	H	PBP superfamily domain	-	-	-	ko:K05772	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	PBP_like_2
PYH3_k127_3924602_10	1220534.B655_2239	1.889e-72	252.0	COG4662@1|root,arCOG00166@2157|Archaea,2XTDY@28890|Euryarchaeota	28890|Euryarchaeota	P	ABC-type tungstate transport system, periplasmic component	tupB	-	-	ko:K05773	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	BPD_transp_1
PYH3_k127_3924602_4	552811.Dehly_0972	2.053e-104	350.0	COG3585@1|root,COG3842@1|root,COG3585@2|Bacteria,COG3842@2|Bacteria	2|Bacteria	P	ATPase activity	gtsA	-	3.6.3.29,3.6.3.30,3.6.3.55	ko:K02010,ko:K02017,ko:K02019,ko:K02049,ko:K02068,ko:K02071,ko:K06857,ko:K10112	ko02010,map02010	M00186,M00188,M00189,M00190,M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00211,M00238,M00491,M00602,M00605,M00606	R10531	RC00002	ko00000,ko00001,ko00002,ko01000,ko02000,ko03000	3.A.1.1,3.A.1.10,3.A.1.16,3.A.1.17,3.A.1.24,3.A.1.6.2,3.A.1.6.4,3.A.1.8	-	-	ABC_tran,TOBE,TOBE_2
PYH3_k127_3924602_2	1244869.H261_02431	1.018e-109	371.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TT4A@28211|Alphaproteobacteria,2JRFR@204441|Rhodospirillales	204441|Rhodospirillales	C	acyl-CoA transferases carnitine dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
PYH3_k127_3924602_16	311424.DhcVS_759	9.675e-21	93.0	2A4FI@1|root,30T1H@2|Bacteria,2GAXA@200795|Chloroflexi,34DIQ@301297|Dehalococcoidia	301297|Dehalococcoidia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_3924602_13	391603.FBALC1_03372	7.986e-41	159.0	COG0500@1|root,COG2226@2|Bacteria,4NEDR@976|Bacteroidetes,1HX52@117743|Flavobacteriia	976|Bacteroidetes	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)	menG	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
PYH3_k127_3924602_6	335543.Sfum_0412	3.65e-91	309.0	COG1575@1|root,COG1575@2|Bacteria,1PWVZ@1224|Proteobacteria,4349B@68525|delta/epsilon subdivisions,2X2PW@28221|Deltaproteobacteria,2MRJX@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	UbiA prenyltransferase family	-	-	2.5.1.74	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R05617,R06858,R10757	RC02935,RC02936,RC03264	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
PYH3_k127_3924602_8	552811.Dehly_1474	3.608e-79	273.0	COG1912@1|root,COG1912@2|Bacteria,2G6NI@200795|Chloroflexi,34D0Z@301297|Dehalococcoidia	301297|Dehalococcoidia	S	S-adenosyl-l-methionine hydroxide adenosyltransferase	-	-	-	ko:K22205	-	-	-	-	ko00000,ko01000	-	-	-	SAM_adeno_trans
PYH3_k127_3924602_17	255470.cbdbA1641	6.533e-18	87.0	COG1314@1|root,COG1314@2|Bacteria,2G7D9@200795|Chloroflexi,34DHN@301297|Dehalococcoidia	301297|Dehalococcoidia	U	Preprotein translocase SecG subunit	secG	-	-	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecG
PYH3_k127_3924602_0	311424.DhcVS_1440	4.574e-195	619.0	COG0064@1|root,COG0064@2|Bacteria,2G62Q@200795|Chloroflexi,34CT7@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	-	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
PYH3_k127_3924602_5	479434.Sthe_1533	7.261e-103	344.0	COG0667@1|root,COG0667@2|Bacteria,2G6BF@200795|Chloroflexi,27YWI@189775|Thermomicrobia	189775|Thermomicrobia	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
PYH3_k127_3924602_18	913325.N799_07000	1.837e-10	65.0	2EIB4@1|root,33C2I@2|Bacteria,1NCTY@1224|Proteobacteria,1T9NM@1236|Gammaproteobacteria,1X8D7@135614|Xanthomonadales	135614|Xanthomonadales	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_3924602_15	1128421.JAGA01000002_gene1111	1.465e-23	108.0	COG0622@1|root,COG0622@2|Bacteria,2NQ04@2323|unclassified Bacteria	2|Bacteria	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	ko:K07095	-	-	-	-	ko00000	-	-	-	Metallophos_2
PYH3_k127_3924602_1	243164.DET0573	2.933e-170	550.0	COG4166@1|root,COG4166@2|Bacteria,2G5TA@200795|Chloroflexi,34CV3@301297|Dehalococcoidia	301297|Dehalococcoidia	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	SBP_bac_5
PYH3_k127_3924602_14	1385512.N784_04785	3.711e-27	119.0	COG1309@1|root,COG1309@2|Bacteria,1UZQU@1239|Firmicutes,4HD4B@91061|Bacilli,2Y9QZ@289201|Pontibacillus	91061|Bacilli	K	TetR family transcriptional regulator	kstR2_2	-	-	-	-	-	-	-	-	-	-	-	TetR_N
PYH3_k127_3924602_3	381666.H16_B0720	3.425e-105	351.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2W114@28216|Betaproteobacteria,1KFFY@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
PYH3_k127_3924602_7	381666.H16_B0719	1.201e-84	291.0	COG1173@1|root,COG1173@2|Bacteria,1MU26@1224|Proteobacteria,2W02P@28216|Betaproteobacteria,1KDF1@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
PYH3_k127_3981851_3	552811.Dehly_1297	9.311e-124	407.0	COG0842@1|root,COG0842@2|Bacteria,2G7IS@200795|Chloroflexi,34CUZ@301297|Dehalococcoidia	301297|Dehalococcoidia	V	ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
PYH3_k127_3981851_2	552811.Dehly_1296	2.2e-133	434.0	COG0842@1|root,COG0842@2|Bacteria	2|Bacteria	V	Transport permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
PYH3_k127_3981851_1	552811.Dehly_1295	2.659e-135	436.0	COG1131@1|root,COG1131@2|Bacteria,2G6HN@200795|Chloroflexi,34D7R@301297|Dehalococcoidia	301297|Dehalococcoidia	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
PYH3_k127_3981851_5	552811.Dehly_1294	1.514e-24	106.0	COG1309@1|root,COG1309@2|Bacteria,2GAQX@200795|Chloroflexi,34D4A@301297|Dehalococcoidia	301297|Dehalococcoidia	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
PYH3_k127_3981851_0	383372.Rcas_0919	1.103e-253	807.0	COG1472@1|root,COG1472@2|Bacteria,2G639@200795|Chloroflexi,374XN@32061|Chloroflexia	32061|Chloroflexia	G	Belongs to the glycosyl hydrolase 3 family	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C,PA14
PYH3_k127_3981851_4	1408303.JNJJ01000146_gene2460	6.721e-45	177.0	COG4974@1|root,COG4974@2|Bacteria,1TQRG@1239|Firmicutes,4HD6Z@91061|Bacilli,1ZC5D@1386|Bacillus	91061|Bacilli	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_1,Phage_int_SAM_4,Phage_int_SAM_5,Phage_integrase
PYH3_k127_4008710_0	243164.DET0061	2.165e-175	559.0	COG0215@1|root,COG0215@2|Bacteria,2G5Z0@200795|Chloroflexi,34CQ5@301297|Dehalococcoidia	301297|Dehalococcoidia	J	cysteinyl-tRNA aminoacylation	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e,tRNA-synt_1g
PYH3_k127_4008710_6	243164.DET0060	6.817e-50	182.0	COG0245@1|root,COG0245@2|Bacteria,2G6RA@200795|Chloroflexi,34D02@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)	ispF	-	4.6.1.12	ko:K01770	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	YgbB
PYH3_k127_4008710_4	311424.DhcVS_59	3.182e-54	200.0	COG1211@1|root,COG1211@2|Bacteria,2G6UP@200795|Chloroflexi,34D6D@301297|Dehalococcoidia	301297|Dehalococcoidia	I	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)	ispD	-	2.7.7.60	ko:K00991	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD
PYH3_k127_4008710_5	768706.Desor_2979	1.042e-53	198.0	COG1024@1|root,COG1024@2|Bacteria,1TQ89@1239|Firmicutes,247RK@186801|Clostridia,26121@186807|Peptococcaceae	186801|Clostridia	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	-	ECH_1
PYH3_k127_4008710_7	243164.DET1315	3.39e-41	164.0	COG0697@1|root,COG0697@2|Bacteria,2GA6A@200795|Chloroflexi,34CPH@301297|Dehalococcoidia	301297|Dehalococcoidia	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
PYH3_k127_4008710_1	1162668.LFE_1514	1.535e-97	327.0	COG0421@1|root,COG0421@2|Bacteria,3J0Y5@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	-	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synt_N,Spermine_synth
PYH3_k127_4008710_8	289376.THEYE_A0245	1.044e-33	133.0	COG1586@1|root,COG1586@2|Bacteria,3J15H@40117|Nitrospirae	40117|Nitrospirae	F	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine	speH	-	4.1.1.50	ko:K01611	ko00270,ko00330,ko01100,map00270,map00330,map01100	M00034,M00133	R00178	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	AdoMet_dc
PYH3_k127_4008710_2	1120917.AQXM01000063_gene2039	4.346e-74	255.0	COG2057@1|root,COG2057@2|Bacteria,2GKV9@201174|Actinobacteria,1W831@1268|Micrococcaceae	201174|Actinobacteria	I	3-oxoacid CoA-transferase, B subunit	scoB	GO:0001666,GO:0006950,GO:0008150,GO:0009628,GO:0036293,GO:0050896,GO:0070482	2.8.3.5	ko:K01029	ko00072,ko00280,ko00650,map00072,map00280,map00650	-	R00410	RC00014	ko00000,ko00001,ko01000	-	-	iNJ661.Rv2503c	CoA_trans
PYH3_k127_4008710_3	1131814.JAFO01000001_gene3735	2.264e-68	239.0	COG1788@1|root,COG1788@2|Bacteria,1MVEI@1224|Proteobacteria,2TTE6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	COG1788 Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit	-	-	2.8.3.6	ko:K01031	ko00362,ko01100,ko01120,map00362,map01100,map01120	-	R02990	RC00014	ko00000,ko00001,ko01000	-	-	-	CoA_trans
PYH3_k127_4019468_4	552811.Dehly_0112	5.438e-09	59.0	COG0240@1|root,COG0240@2|Bacteria,2G5W5@200795|Chloroflexi,34CNA@301297|Dehalococcoidia	301297|Dehalococcoidia	I	glycerolipid metabolic process	gpsA	GO:0003674,GO:0003824,GO:0004367,GO:0006072,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0019637,GO:0044237,GO:0046167,GO:0052646,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901576	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
PYH3_k127_4019468_2	255470.cbdbA1355	1.773e-66	235.0	COG0344@1|root,COG0344@2|Bacteria,2G6U5@200795|Chloroflexi,34D23@301297|Dehalococcoidia	301297|Dehalococcoidia	I	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP	-	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
PYH3_k127_4019468_0	552811.Dehly_0110	4.785e-143	467.0	COG1160@1|root,COG1160@2|Bacteria,2G5M0@200795|Chloroflexi,34D94@301297|Dehalococcoidia	301297|Dehalococcoidia	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
PYH3_k127_4019468_1	311424.DhcVS_1176	1.003e-115	380.0	COG0078@1|root,COG0078@2|Bacteria,2G5Z9@200795|Chloroflexi,34D9J@301297|Dehalococcoidia	301297|Dehalococcoidia	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	-	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
PYH3_k127_4019468_3	575590.HMPREF0156_01407	2.409e-10	65.0	COG1308@1|root,COG1308@2|Bacteria,4NVAE@976|Bacteroidetes	976|Bacteroidetes	K	Domain of unknown function (DUF4342)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4342
PYH3_k127_4019468_5	1380367.JIBC01000006_gene587	0.0001668	44.0	COG1024@1|root,COG1024@2|Bacteria,1MVQN@1224|Proteobacteria,2TUXD@28211|Alphaproteobacteria,3ZV69@60136|Sulfitobacter	28211|Alphaproteobacteria	I	Enoyl-CoA hydratase/isomerase	paaG	-	5.3.3.18	ko:K15866	ko00360,ko01120,map00360,map01120	-	R09837,R09839	RC00004,RC00326,RC02689,RC03003	ko00000,ko00001,ko01000	-	-	-	ECH_1
PYH3_k127_4068411_1	266264.Rmet_4576	9.883e-80	273.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2W114@28216|Betaproteobacteria,1KFFY@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
PYH3_k127_4068411_0	1205680.CAKO01000040_gene1106	2.414e-81	282.0	COG1173@1|root,COG1173@2|Bacteria,1MXGS@1224|Proteobacteria,2TTQ7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EP	COG1173 ABC-type dipeptide oligopeptide nickel transport systems permease components	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
PYH3_k127_4068411_2	592015.HMPREF1705_02026	1.379e-48	184.0	COG0778@1|root,COG0778@2|Bacteria,3TCD8@508458|Synergistetes	508458|Synergistetes	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
PYH3_k127_4075219_2	552811.Dehly_1386	5.868e-59	209.0	COG4152@1|root,COG4152@2|Bacteria,2G60H@200795|Chloroflexi,34D1D@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Domain of unknown function (DUF4162)	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
PYH3_k127_4075219_0	552811.Dehly_1385	1.361e-121	402.0	COG1668@1|root,COG1668@2|Bacteria,2G8PJ@200795|Chloroflexi,34CR3@301297|Dehalococcoidia	301297|Dehalococcoidia	CP	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
PYH3_k127_4075219_1	1047013.AQSP01000109_gene2441	2.516e-81	276.0	COG0500@1|root,COG2226@2|Bacteria,2NP8K@2323|unclassified Bacteria	2|Bacteria	Q	ubiE/COQ5 methyltransferase family	arsM	-	2.1.1.137,2.1.1.79	ko:K00574,ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_31
PYH3_k127_4075219_3	1047013.AQSP01000109_gene2440	9.198e-27	112.0	COG2002@1|root,COG2002@2|Bacteria	2|Bacteria	K	toxin-antitoxin pair type II binding	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin
PYH3_k127_4167289_9	1280946.HY29_13295	2.814e-119	400.0	COG2079@1|root,COG2079@2|Bacteria,1R5CE@1224|Proteobacteria,2TUP7@28211|Alphaproteobacteria,43Z1E@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	MmgE/PrpD family	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
PYH3_k127_4167289_13	665577.JH993790_gene2794	4.022e-72	259.0	COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria	201174|Actinobacteria	I	Belongs to the thiolase family	fadA2	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
PYH3_k127_4167289_32	1218074.BAXZ01000004_gene1146	1.286e-05	48.0	COG0586@1|root,COG0607@1|root,COG0586@2|Bacteria,COG0607@2|Bacteria,1R6F1@1224|Proteobacteria,2WEB2@28216|Betaproteobacteria,1KFV3@119060|Burkholderiaceae	28216|Betaproteobacteria	P	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese,SNARE_assoc
PYH3_k127_4167289_30	760192.Halhy_0083	6.938e-10	64.0	COG2272@1|root,COG2272@2|Bacteria,4NF5N@976|Bacteroidetes,1IQ9M@117747|Sphingobacteriia	976|Bacteroidetes	I	Belongs to the type-B carboxylesterase lipase family	-	-	-	ko:K03929	-	-	-	-	ko00000,ko01000	-	CE10	-	COesterase
PYH3_k127_4167289_7	1206743.BAGM01000199_gene975	1.525e-135	449.0	COG2272@1|root,COG2272@2|Bacteria,2GJCN@201174|Actinobacteria,4G5Z2@85025|Nocardiaceae	201174|Actinobacteria	I	Carboxylesterase family	-	-	-	ko:K03929	-	-	-	-	ko00000,ko01000	-	CE10	-	COesterase
PYH3_k127_4167289_16	335543.Sfum_3444	2.306e-65	229.0	COG1853@1|root,COG1853@2|Bacteria,1RAIQ@1224|Proteobacteria,42RZG@68525|delta/epsilon subdivisions,2WNTA@28221|Deltaproteobacteria,2MQKN@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Flavin reductase like domain	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
PYH3_k127_4167289_17	555088.DealDRAFT_2094	1.676e-59	209.0	COG1661@1|root,COG1661@2|Bacteria,1VFBA@1239|Firmicutes,24QM1@186801|Clostridia	186801|Clostridia	S	Domain of unknown function (DUF296)	-	-	-	-	-	-	-	-	-	-	-	-	DUF296
PYH3_k127_4167289_3	243164.DET0549	1.691e-167	557.0	COG0419@1|root,COG0419@2|Bacteria,2G682@200795|Chloroflexi,34CWU@301297|Dehalococcoidia	301297|Dehalococcoidia	L	Putative exonuclease SbcCD, C subunit	-	-	-	ko:K03546	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,SbcCD_C
PYH3_k127_4167289_25	313628.LNTAR_06274	1.005e-28	120.0	COG5628@1|root,COG5628@2|Bacteria	2|Bacteria	J	-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
PYH3_k127_4167289_14	243164.DET0547	7.35e-68	235.0	COG2316@1|root,COG2316@2|Bacteria,2G6T2@200795|Chloroflexi,34D14@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	-	-	-	-	-	-	-	-	-	HD
PYH3_k127_4167289_0	552811.Dehly_0797	0.0	1401.0	COG0178@1|root,COG0178@2|Bacteria,2G60U@200795|Chloroflexi,34CMB@301297|Dehalococcoidia	301297|Dehalococcoidia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
PYH3_k127_4167289_26	247490.KSU1_B0483	1.746e-25	107.0	COG0425@1|root,COG0425@2|Bacteria	2|Bacteria	O	sulfur carrier activity	-	-	-	-	-	-	-	-	-	-	-	-	DrsE,TusA
PYH3_k127_4167289_20	706587.Desti_4733	8.513e-53	188.0	COG0822@1|root,COG0822@2|Bacteria,1RD5K@1224|Proteobacteria,42MT6@68525|delta/epsilon subdivisions,2WJBU@28221|Deltaproteobacteria,2MRQU@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	NifU-like N terminal domain	iscU	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
PYH3_k127_4167289_4	429009.Adeg_0423	5.846e-151	486.0	COG1104@1|root,COG1104@2|Bacteria,1TP21@1239|Firmicutes,24888@186801|Clostridia,42FGX@68295|Thermoanaerobacterales	186801|Clostridia	H	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
PYH3_k127_4167289_1	1047013.AQSP01000120_gene942	2.443e-280	884.0	COG2217@1|root,COG2217@2|Bacteria,2NNPJ@2323|unclassified Bacteria	2|Bacteria	P	E1-E2 ATPase	-	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase,YHS
PYH3_k127_4167289_29	593750.Metfor_1237	1.418e-13	72.0	COG3350@1|root,arCOG04507@2157|Archaea	2157|Archaea	P	PFAM YHS domain	-	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hydrolase,YHS
PYH3_k127_4167289_28	552811.Dehly_1198	4.649e-17	83.0	2CEZQ@1|root,33C4G@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_4167289_11	760568.Desku_2692	2.003e-100	336.0	COG3634@1|root,COG3634@2|Bacteria,1UIUB@1239|Firmicutes,25ES4@186801|Clostridia,267GT@186807|Peptococcaceae	186801|Clostridia	C	Pyridine nucleotide-disulphide oxidoreductase	ahpF	-	-	ko:K03387	-	-	-	-	ko00000,ko01000	-	-	-	Glutaredoxin,Pyr_redox_2,Thioredoxin_3
PYH3_k127_4167289_27	660470.Theba_1526	2.035e-21	94.0	COG0695@1|root,COG0695@2|Bacteria,2GD7W@200918|Thermotogae	200918|Thermotogae	O	glutaredoxin-like protein, YruB-family	-	-	-	-	-	-	-	-	-	-	-	-	Glutaredoxin
PYH3_k127_4167289_2	926569.ANT_14030	4.64e-196	632.0	COG0480@1|root,COG0480@2|Bacteria,2G680@200795|Chloroflexi	200795|Chloroflexi	J	elongation factor Tu domain 2 protein	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
PYH3_k127_4167289_19	909663.KI867150_gene2256	3.852e-57	204.0	COG0778@1|root,COG0778@2|Bacteria,1PDTZ@1224|Proteobacteria,42SQ3@68525|delta/epsilon subdivisions,2WPC5@28221|Deltaproteobacteria,2MQPP@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
PYH3_k127_4167289_24	311424.DhcVS_781	4.68e-34	151.0	COG2211@1|root,COG2211@2|Bacteria,2G6WX@200795|Chloroflexi,34CJ4@301297|Dehalococcoidia	301297|Dehalococcoidia	G	MFS_1 like family	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
PYH3_k127_4167289_6	1094980.Mpsy_2655	6.318e-140	455.0	COG1055@1|root,arCOG00238@2157|Archaea,2XVDU@28890|Euryarchaeota,2N961@224756|Methanomicrobia	224756|Methanomicrobia	P	Citrate transporter	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS
PYH3_k127_4167289_10	945713.IALB_0513	3.817e-106	349.0	COG0708@1|root,COG0708@2|Bacteria	2|Bacteria	L	double-stranded DNA 3'-5' exodeoxyribonuclease activity	xth	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
PYH3_k127_4167289_5	1121468.AUBR01000016_gene2318	1.133e-142	464.0	COG0624@1|root,COG0624@2|Bacteria,1TR99@1239|Firmicutes,248DC@186801|Clostridia,42FC4@68295|Thermoanaerobacterales	186801|Clostridia	E	Peptidase dimerisation domain	-	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
PYH3_k127_4167289_18	552811.Dehly_1300	7.813e-58	207.0	COG0655@1|root,COG0655@2|Bacteria,2GAKP@200795|Chloroflexi,34CPA@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Flavodoxin-like fold	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
PYH3_k127_4167289_23	255470.cbdbA1322	2.165e-34	137.0	COG0319@1|root,COG0319@2|Bacteria,2G78D@200795|Chloroflexi,34D1F@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA	ybeY	-	-	ko:K07042	-	-	-	-	ko00000,ko03009	-	-	-	UPF0054
PYH3_k127_4167289_22	552811.Dehly_0065	1.125e-34	137.0	COG0735@1|root,COG0735@2|Bacteria,2G74Y@200795|Chloroflexi,34DBQ@301297|Dehalococcoidia	301297|Dehalococcoidia	K	Ferric uptake regulator family	-	-	-	ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
PYH3_k127_4167289_31	32057.KB217478_gene7479	1.012e-06	54.0	2A4E9@1|root,30T03@2|Bacteria,1GIS8@1117|Cyanobacteria,1HPJQ@1161|Nostocales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_4167289_15	1047013.AQSP01000079_gene2038	4.885e-66	233.0	arCOG06621@1|root,33A1X@2|Bacteria,2NRVC@2323|unclassified Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_4167289_12	933262.AXAM01000022_gene3217	3.626e-86	293.0	COG1237@1|root,COG1237@2|Bacteria,1NK2I@1224|Proteobacteria,42QRA@68525|delta/epsilon subdivisions,2WN1V@28221|Deltaproteobacteria,2MK22@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	2.5.1.105	ko:K06897	ko00790,map00790	-	R10339	RC00121	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
PYH3_k127_4167289_8	243164.DET1372	8.351e-124	404.0	COG0167@1|root,COG0167@2|Bacteria,2G6RH@200795|Chloroflexi,34CMM@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily	pyrD	-	1.3.1.14	ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
PYH3_k127_4167289_21	56780.SYN_03204	1.822e-49	184.0	COG0084@1|root,COG0084@2|Bacteria,1MUC0@1224|Proteobacteria,42MMS@68525|delta/epsilon subdivisions,2WMUI@28221|Deltaproteobacteria,2MQH5@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	TIGRFAM hydrolase, TatD family	tatD	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_14,Radical_SAM,TatD_DNase
PYH3_k127_417855_1	552811.Dehly_1402	1.761e-140	457.0	COG0612@1|root,COG0612@2|Bacteria,2G672@200795|Chloroflexi,34CMZ@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Insulinase (Peptidase family M16)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
PYH3_k127_417855_0	552811.Dehly_1027	5.96e-162	518.0	COG0436@1|root,COG0436@2|Bacteria,2G5MC@200795|Chloroflexi,34CNM@301297|Dehalococcoidia	301297|Dehalococcoidia	E	DegT/DnrJ/EryC1/StrS aminotransferase family	aspC	-	-	ko:K10907	-	-	-	-	ko00000,ko01000,ko01007	-	-	-	Aminotran_1_2
PYH3_k127_417855_2	311424.DhcVS_1123	9.395e-61	213.0	COG1522@1|root,COG1522@2|Bacteria,2GASX@200795|Chloroflexi,34DA3@301297|Dehalococcoidia	301297|Dehalococcoidia	K	Lrp/AsnC ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
PYH3_k127_417855_3	552811.Dehly_1039	4.6e-40	149.0	COG0154@1|root,COG0154@2|Bacteria,2G5T0@200795|Chloroflexi,34CJK@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
PYH3_k127_4193216_2	552811.Dehly_0929	9.03e-64	221.0	COG3259@1|root,COG3259@2|Bacteria,2G68W@200795|Chloroflexi,34CQT@301297|Dehalococcoidia	2|Bacteria	C	hydrogenase large subunit	hoxH	-	1.12.1.2,1.8.98.5	ko:K00436,ko:K14126	ko00680,map00680	-	R00019,R00700,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
PYH3_k127_4193216_1	552811.Dehly_0928	2.744e-116	379.0	COG1941@1|root,COG1941@2|Bacteria,2G8TW@200795|Chloroflexi	200795|Chloroflexi	C	NADH ubiquinone oxidoreductase, 20 Kd subunit	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_q6
PYH3_k127_4193216_0	552811.Dehly_0927	1.725e-284	890.0	COG0543@1|root,COG2204@1|root,COG0543@2|Bacteria,COG2204@2|Bacteria,2G7HU@200795|Chloroflexi	200795|Chloroflexi	C	Oxidoreductase NAD-binding domain	-	-	1.18.1.3	ko:K15765	ko00623,ko00920,ko01100,ko01120,ko01220,map00623,map00920,map01100,map01120,map01220	M00538	R02550,R03562,R05666,R09513	RC00269,RC00490,RC02556	ko00000,ko00001,ko00002,ko01000	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
PYH3_k127_4206730_2	1304880.JAGB01000002_gene1929	1.378e-38	147.0	COG1136@1|root,COG1136@2|Bacteria,1TPMF@1239|Firmicutes,24BH4@186801|Clostridia	186801|Clostridia	V	Abc transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
PYH3_k127_4206730_0	459349.CLOAM0193	2.357e-123	448.0	COG4886@1|root,COG4886@2|Bacteria	2|Bacteria	S	regulation of response to stimulus	-	-	-	ko:K13730	ko05100,map05100	-	-	-	ko00000,ko00001	-	-	-	COR,LRR_4,LRR_6,LRR_8,Roc
PYH3_k127_4206730_4	192952.MM_0844	7.542e-18	89.0	arCOG03467@1|root,arCOG03467@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_4206730_1	768706.Desor_0870	3.865e-55	205.0	COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,247PV@186801|Clostridia,260VS@186807|Peptococcaceae	186801|Clostridia	IQ	PFAM short chain dehydrogenase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short,adh_short_C2
PYH3_k127_4206730_3	1131266.ARWQ01000003_gene1561	7.831e-21	104.0	COG0500@1|root,arCOG01402@2157|Archaea	2157|Archaea	Q	TIGRFAM methyltransferase FkbM	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_21
PYH3_k127_4206730_5	1297865.APJD01000014_gene453	5.947e-14	74.0	COG1266@1|root,COG1266@2|Bacteria,1QPQ0@1224|Proteobacteria,2TTX7@28211|Alphaproteobacteria,3JSCR@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
PYH3_k127_426105_2	621372.ACIH01000136_gene1826	9.449e-15	80.0	COG1063@1|root,COG1063@2|Bacteria,1TS6I@1239|Firmicutes,4HCC1@91061|Bacilli,27620@186822|Paenibacillaceae	91061|Bacilli	E	Glucose dehydrogenase C-terminus	gutB	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
PYH3_k127_426105_1	316274.Haur_4532	1.573e-34	152.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,2G7M2@200795|Chloroflexi,377Z3@32061|Chloroflexia	32061|Chloroflexia	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
PYH3_k127_426105_0	1298593.TOL_0070	7.171e-40	163.0	COG3853@1|root,COG3853@2|Bacteria,1MY18@1224|Proteobacteria,1RZ1H@1236|Gammaproteobacteria,1XMQ5@135619|Oceanospirillales	135619|Oceanospirillales	P	Toxic anion resistance	-	-	-	-	-	-	-	-	-	-	-	-	TelA
PYH3_k127_432758_2	552811.Dehly_1478	4.606e-52	188.0	COG0691@1|root,COG0691@2|Bacteria,2G6NE@200795|Chloroflexi,34D98@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene	smpB	-	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
PYH3_k127_432758_0	1121405.dsmv_2374	1.361e-137	447.0	COG0247@1|root,COG0247@2|Bacteria,1MUMH@1224|Proteobacteria,42N5J@68525|delta/epsilon subdivisions,2WJ6B@28221|Deltaproteobacteria,2MJHX@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	bamD	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_17,Fer4_8
PYH3_k127_432758_1	264732.Moth_0810	6.623e-89	301.0	COG2048@1|root,COG2048@2|Bacteria,1U4JW@1239|Firmicutes,24C8P@186801|Clostridia,42FS6@68295|Thermoanaerobacterales	186801|Clostridia	C	Cysteine-rich domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
PYH3_k127_443013_2	69014.TK2188	1.895e-33	143.0	arCOG04615@1|root,arCOG04615@2157|Archaea,2Y2IE@28890|Euryarchaeota,244Z1@183968|Thermococci	183968|Thermococci	S	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
PYH3_k127_443013_1	1300143.CCAV010000008_gene3495	4.512e-68	235.0	COG2818@1|root,COG2818@2|Bacteria,4NGRC@976|Bacteroidetes,1HYH3@117743|Flavobacteriia,3ZR1I@59732|Chryseobacterium	976|Bacteroidetes	L	Methyladenine glycosylase	tag	-	3.2.2.20	ko:K01246	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Adenine_glyco
PYH3_k127_443013_3	583355.Caka_0800	1.25e-10	68.0	COG0346@1|root,COG0346@2|Bacteria,46VJH@74201|Verrucomicrobia,3K82H@414999|Opitutae	414999|Opitutae	E	Glyoxalase-like domain	-	-	5.1.99.1	ko:K05606	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R02765,R09979	RC00780,RC02739	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase_4
PYH3_k127_443013_0	573413.Spirs_0106	1.267e-90	301.0	COG1053@1|root,COG1053@2|Bacteria	2|Bacteria	C	succinate dehydrogenase	aprA	-	1.8.99.2	ko:K00394	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00596	R00860,R04927,R08553	RC00007,RC01239,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
PYH3_k127_4459536_6	479434.Sthe_3486	2.65e-108	359.0	COG4867@1|root,COG4867@2|Bacteria,2G8A6@200795|Chloroflexi,27XPF@189775|Thermomicrobia	189775|Thermomicrobia	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_4459536_10	439235.Dalk_1691	1.693e-76	275.0	COG1042@1|root,COG1042@2|Bacteria,1MW98@1224|Proteobacteria	1224|Proteobacteria	C	CoA-binding domain protein	MA20_15065	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
PYH3_k127_4459536_9	439235.Dalk_5191	6.597e-78	279.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,42NTV@68525|delta/epsilon subdivisions,2WJTP@28221|Deltaproteobacteria,2MIWR@213118|Desulfobacterales	1224|Proteobacteria	C	PFAM CoA-binding domain protein	MA20_15065	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
PYH3_k127_4459536_7	255470.cbdbA376	2.917e-93	310.0	COG1738@1|root,COG1738@2|Bacteria,2G6BZ@200795|Chloroflexi,34CTR@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage	-	-	-	ko:K09125	-	-	-	-	ko00000	-	-	-	Vut_1
PYH3_k127_4459536_12	552811.Dehly_1051	8.251e-52	193.0	COG1234@1|root,COG1234@2|Bacteria	2|Bacteria	L	tRNA 3'-trailer cleavage	-	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
PYH3_k127_4459536_15	255470.cbdbA378	8.08e-35	138.0	COG1656@1|root,COG1656@2|Bacteria,2G6GZ@200795|Chloroflexi,34DKC@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Mut7-C RNAse domain	-	-	-	ko:K09122	-	-	-	-	ko00000	-	-	-	Mut7-C
PYH3_k127_4459536_8	255470.cbdbA381	2.873e-92	310.0	COG1521@1|root,COG1521@2|Bacteria,2G6B4@200795|Chloroflexi,34CP6@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis	coaX	-	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Pan_kinase
PYH3_k127_4459536_5	1123288.SOV_4c06750	2.894e-117	390.0	COG0452@1|root,COG0452@2|Bacteria,1TPP3@1239|Firmicutes,4H27H@909932|Negativicutes	909932|Negativicutes	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
PYH3_k127_4459536_0	255470.cbdbA384	0.0	1107.0	COG0525@1|root,COG0525@2|Bacteria,2G5VS@200795|Chloroflexi,34D5F@301297|Dehalococcoidia	301297|Dehalococcoidia	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
PYH3_k127_4459536_13	255470.cbdbA387	2.129e-49	184.0	2A4BY@1|root,30SXK@2|Bacteria,2GASQ@200795|Chloroflexi,34D9B@301297|Dehalococcoidia	301297|Dehalococcoidia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_4459536_16	56780.SYN_00286	7.882e-14	76.0	COG1387@1|root,COG1796@1|root,COG1387@2|Bacteria,COG1796@2|Bacteria,1MYXV@1224|Proteobacteria,42MQX@68525|delta/epsilon subdivisions,2WKUP@28221|Deltaproteobacteria,2MRF6@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	DNA polymerase X family	-	-	-	ko:K02347	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_palm,DNA_pol_B_thumb,HHH_5,HHH_8,PHP
PYH3_k127_4459536_1	311424.DhcVS_376	0.0	1020.0	COG0653@1|root,COG0653@2|Bacteria,2G603@200795|Chloroflexi,34CZU@301297|Dehalococcoidia	301297|Dehalococcoidia	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
PYH3_k127_4459536_4	552811.Dehly_1132	2.051e-142	457.0	COG0462@1|root,COG0462@2|Bacteria,2G5T8@200795|Chloroflexi,34CYP@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
PYH3_k127_4459536_14	269799.Gmet_0156	7.638e-35	136.0	COG3189@1|root,COG3189@2|Bacteria,1MZ7H@1224|Proteobacteria,42U37@68525|delta/epsilon subdivisions,2WQ9M@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Protein of unknown function, DUF488	-	-	-	-	-	-	-	-	-	-	-	-	DUF488
PYH3_k127_4459536_3	255470.cbdbA390	1.229e-163	529.0	COG0112@1|root,COG0112@2|Bacteria,2G624@200795|Chloroflexi,34CQP@301297|Dehalococcoidia	301297|Dehalococcoidia	H	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
PYH3_k127_4459536_11	311424.DhcVS_379	2.464e-70	244.0	COG1573@1|root,COG1573@2|Bacteria,2G6BR@200795|Chloroflexi,34CY0@301297|Dehalococcoidia	301297|Dehalococcoidia	L	UreE urease accessory protein, C-terminal domain	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
PYH3_k127_4459536_2	243164.DET0438	3.425e-244	764.0	COG0595@1|root,COG0595@2|Bacteria,2G611@200795|Chloroflexi,34CSJ@301297|Dehalococcoidia	301297|Dehalococcoidia	J	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay	rnj	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,RMMBL
PYH3_k127_4459536_17	243164.DET0439	8.369e-05	49.0	COG1674@1|root,COG1674@2|Bacteria,2G5XC@200795|Chloroflexi,34CZW@301297|Dehalococcoidia	301297|Dehalococcoidia	D	Ftsk_gamma	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_SpoIIIE,Ftsk_gamma
PYH3_k127_4579295_8	196162.Noca_1178	1.312e-09	64.0	COG0491@1|root,COG0491@2|Bacteria,2HFVZ@201174|Actinobacteria,4DVND@85009|Propionibacteriales	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	ko:K05555	ko01057,ko01130,map01057,map01130	M00778	R09305	-	ko00000,ko00001,ko00002,ko01000,ko01008	-	-	-	FAA_hydrolase,Lactamase_B
PYH3_k127_4579295_5	316274.Haur_2614	1.11e-54	201.0	COG1028@1|root,COG1028@2|Bacteria,2G5KB@200795|Chloroflexi,3759E@32061|Chloroflexia	316274.Haur_2614|-	IQ	short-chain dehydrogenase reductase SDR	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_4579295_2	1205680.CAKO01000040_gene1106	7.196e-98	329.0	COG1173@1|root,COG1173@2|Bacteria,1MXGS@1224|Proteobacteria,2TTQ7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EP	COG1173 ABC-type dipeptide oligopeptide nickel transport systems permease components	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
PYH3_k127_4579295_1	1297865.APJD01000009_gene2849	3.28e-105	350.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TR0N@28211|Alphaproteobacteria,3JUIB@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
PYH3_k127_4579295_3	1429916.X566_03930	1.846e-88	314.0	COG0747@1|root,COG0747@2|Bacteria,1PFW6@1224|Proteobacteria,2U1GT@28211|Alphaproteobacteria,3JUHW@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Peptide ABC transporter substrate-binding protein	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
PYH3_k127_4579295_4	1185652.USDA257_c18230	2.702e-77	276.0	COG2079@1|root,COG2079@2|Bacteria,1R5UM@1224|Proteobacteria,2U1F8@28211|Alphaproteobacteria,4BNFQ@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	MmgE/PrpD family	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
PYH3_k127_4579295_6	401526.TcarDRAFT_1409	2.627e-30	128.0	COG1802@1|root,COG1802@2|Bacteria,1TSV2@1239|Firmicutes,4H2JT@909932|Negativicutes	909932|Negativicutes	K	FCD domain protein	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
PYH3_k127_4579295_0	641491.DND132_0960	1.575e-107	374.0	COG3379@1|root,COG3379@2|Bacteria,1NBJ6@1224|Proteobacteria,42PUB@68525|delta/epsilon subdivisions,2WMH5@28221|Deltaproteobacteria,2M93I@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM type I phosphodiesterase nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
PYH3_k127_4579295_7	318424.EU78_10165	2.445e-15	77.0	COG1804@1|root,COG1804@2|Bacteria,2GRB0@201174|Actinobacteria,235AT@1762|Mycobacteriaceae	201174|Actinobacteria	C	PFAM CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
PYH3_k127_4623897_15	909613.UO65_2013	9.392e-06	54.0	COG1404@1|root,COG1404@2|Bacteria,2IEGJ@201174|Actinobacteria,4DXZF@85010|Pseudonocardiales	201174|Actinobacteria	O	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,CarboxypepD_reg,Malectin,Peptidase_S8
PYH3_k127_4623897_7	1382306.JNIM01000001_gene1045	1.214e-66	235.0	COG2197@1|root,COG2197@2|Bacteria,2G6PA@200795|Chloroflexi	200795|Chloroflexi	K	Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
PYH3_k127_4623897_10	871963.Desdi_0959	3.269e-50	203.0	COG2203@1|root,COG4585@1|root,COG5000@1|root,COG2203@2|Bacteria,COG4585@2|Bacteria,COG5000@2|Bacteria,1TR88@1239|Firmicutes,250AK@186801|Clostridia,264XI@186807|Peptococcaceae	186801|Clostridia	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HAMP,HATPase_c,HisKA_3,PAS_9
PYH3_k127_4623897_1	1379698.RBG1_1C00001G0778	1.25e-89	308.0	COG3005@1|root,COG3005@2|Bacteria,2NQ9M@2323|unclassified Bacteria	2|Bacteria	C	NapC/NirT cytochrome c family, N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_NNT,Cytochrom_c3_2
PYH3_k127_4623897_9	1487923.DP73_01740	5.548e-55	201.0	COG2864@1|root,COG2864@2|Bacteria,1V1XF@1239|Firmicutes,24GTD@186801|Clostridia,263XV@186807|Peptococcaceae	186801|Clostridia	C	PFAM Cytochrome b(N-terminal) b6 petB	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB
PYH3_k127_4623897_11	290397.Adeh_2002	1.504e-35	148.0	COG3005@1|root,COG3005@2|Bacteria,1QYG3@1224|Proteobacteria,43CC8@68525|delta/epsilon subdivisions,2X7N4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Cytochrome c3	-	-	-	-	-	-	-	-	-	-	-	-	Paired_CXXCH_1
PYH3_k127_4623897_12	44060.JODL01000002_gene2330	7.766e-22	103.0	COG2197@1|root,COG2197@2|Bacteria,2GJHH@201174|Actinobacteria	201174|Actinobacteria	T	Response regulator receiver	-	-	-	ko:K07696	ko02020,map02020	M00483	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
PYH3_k127_4623897_2	348780.NP_4944A	9.732e-84	294.0	COG5557@1|root,arCOG02025@2157|Archaea,2XTP4@28890|Euryarchaeota,23S4Z@183963|Halobacteria	183963|Halobacteria	C	Polysulphide reductase	-	-	-	ko:K00185	-	-	-	-	ko00000	5.A.3	-	-	NrfD
PYH3_k127_4623897_8	448385.sce4705	2.797e-57	213.0	COG0437@1|root,COG0437@2|Bacteria,1NBU3@1224|Proteobacteria,42MNU@68525|delta/epsilon subdivisions,2WJRG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	dsrO	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_11,Fer4_4
PYH3_k127_4623897_13	1121007.AUML01000022_gene841	1.615e-12	76.0	28JYU@1|root,2Z9NZ@2|Bacteria,4NKTR@976|Bacteroidetes,1I0RC@117743|Flavobacteriia,2YJ0V@290174|Aquimarina	976|Bacteroidetes	P	Doubled CXXCH motif (Paired_CXXCH_1)	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,Cytochrome_C7,Paired_CXXCH_1
PYH3_k127_4623897_5	479434.Sthe_1856	6.143e-74	257.0	COG0330@1|root,COG0330@2|Bacteria,2G5SB@200795|Chloroflexi,27XRQ@189775|Thermomicrobia	189775|Thermomicrobia	O	prohibitin homologues	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
PYH3_k127_4623897_3	485913.Krac_6669	6.221e-75	258.0	COG2197@1|root,COG2197@2|Bacteria,2G6PA@200795|Chloroflexi	200795|Chloroflexi	K	Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
PYH3_k127_4623897_6	404589.Anae109_1809	7.577e-74	271.0	COG4585@1|root,COG4585@2|Bacteria,1N0JE@1224|Proteobacteria,42UG3@68525|delta/epsilon subdivisions,2WQFT@28221|Deltaproteobacteria,2Z1DF@29|Myxococcales	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA_3
PYH3_k127_4623897_0	485913.Krac_8718	3.725e-123	403.0	COG0714@1|root,COG0714@2|Bacteria,2G669@200795|Chloroflexi	200795|Chloroflexi	S	ATPase associated with various cellular activities, AAA_3	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
PYH3_k127_4623897_4	479434.Sthe_3135	7.539e-75	268.0	COG1721@1|root,COG1721@2|Bacteria,2G6Y7@200795|Chloroflexi,27Y3Z@189775|Thermomicrobia	189775|Thermomicrobia	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
PYH3_k127_4782394_2	386456.JQKN01000001_gene2331	9.732e-77	269.0	COG0451@1|root,arCOG01369@2157|Archaea,2XUDM@28890|Euryarchaeota	28890|Euryarchaeota	M	NAD-dependent epimerase dehydratase	-	-	1.1.1.219	ko:K00091	-	-	-	-	ko00000,ko01000	-	-	-	Epimerase
PYH3_k127_4782394_3	1121946.AUAX01000022_gene3840	7.453e-76	261.0	2DBF0@1|root,2Z8VT@2|Bacteria,2I88D@201174|Actinobacteria,4DIBF@85008|Micromonosporales	201174|Actinobacteria	S	3-oxo-5-alpha-steroid 4-dehydrogenase	-	-	1.3.1.22	ko:K12343	ko00140,map00140	-	R02208,R02497,R08954,R10242	RC00145	ko00000,ko00001,ko01000	-	-	-	Steroid_dh
PYH3_k127_4782394_7	1120985.AUMI01000012_gene16	1.887e-32	136.0	2DPHF@1|root,33237@2|Bacteria	2|Bacteria	S	L-2-amino-thiazoline-4-carboxylic acid hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	ATC_hydrolase
PYH3_k127_4782394_8	552811.Dehly_1717	4.425e-21	103.0	COG1983@1|root,COG1983@2|Bacteria	2|Bacteria	KT	positive regulation of macromolecule biosynthetic process	-	-	-	ko:K03973	-	-	-	-	ko00000,ko02048,ko03000	-	-	-	DUF2807,PspC
PYH3_k127_4782394_10	748449.Halha_1028	1.867e-08	63.0	COG4635@1|root,COG4635@2|Bacteria,1V6RV@1239|Firmicutes,24N9M@186801|Clostridia	186801|Clostridia	CH	Flavodoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_5
PYH3_k127_4782394_4	926550.CLDAP_21020	2.76e-72	251.0	COG2197@1|root,COG2197@2|Bacteria,2G8EU@200795|Chloroflexi	200795|Chloroflexi	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
PYH3_k127_4782394_6	765420.OSCT_2236	1.448e-57	222.0	COG3292@1|root,COG3829@1|root,COG4585@1|root,COG3292@2|Bacteria,COG3829@2|Bacteria,COG4585@2|Bacteria,2G7P1@200795|Chloroflexi	200795|Chloroflexi	T	Two component regulator propeller	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Reg_prop,Y_Y_Y
PYH3_k127_4782394_5	572544.Ilyop_1530	4.911e-62	227.0	COG1744@1|root,COG1744@2|Bacteria,3796B@32066|Fusobacteria	32066|Fusobacteria	S	basic membrane	-	-	-	ko:K07335	-	-	-	-	ko00000	-	-	-	Bmp
PYH3_k127_4782394_11	330084.JNYZ01000007_gene8697	0.000267	51.0	2DWTH@1|root,341T2@2|Bacteria,2INS2@201174|Actinobacteria,4E4CF@85010|Pseudonocardiales	201174|Actinobacteria	S	Protein of unknown function (DUF998)	-	-	-	-	-	-	-	-	-	-	-	-	DUF998
PYH3_k127_4782394_9	351160.RCIX2474	1.937e-18	89.0	arCOG06717@1|root,arCOG06717@2157|Archaea,2Y1S1@28890|Euryarchaeota,2NA4U@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_4782394_1	1380390.JIAT01000011_gene2348	1.535e-120	415.0	COG1366@1|root,COG2409@1|root,COG1366@2|Bacteria,COG2409@2|Bacteria,2GJ5A@201174|Actinobacteria,4CR8Y@84995|Rubrobacteria	84995|Rubrobacteria	T	MMPL family	-	-	-	-	-	-	-	-	-	-	-	-	MMPL,STAS_2
PYH3_k127_4782394_0	1122918.KB907249_gene3872	5.023e-142	466.0	COG2272@1|root,COG2272@2|Bacteria,1UXY5@1239|Firmicutes,4HCKV@91061|Bacilli,26S80@186822|Paenibacillaceae	91061|Bacilli	I	Belongs to the type-B carboxylesterase lipase family	-	-	-	ko:K03929	-	-	-	-	ko00000,ko01000	-	CE10	-	COesterase
PYH3_k127_4788309_19	387631.Asulf_00796	1.533e-10	62.0	COG2835@1|root,arCOG04124@2157|Archaea,2XZRS@28890|Euryarchaeota,247DV@183980|Archaeoglobi	183980|Archaeoglobi	S	Belongs to the UPF0434 family	-	-	-	-	-	-	-	-	-	-	-	-	Trm112p
PYH3_k127_4788309_13	255470.cbdbA1699	2.466e-39	150.0	COG0720@1|root,COG0720@2|Bacteria,2G7B6@200795|Chloroflexi,34DDV@301297|Dehalococcoidia	301297|Dehalococcoidia	H	6-pyruvoyl tetrahydropterin synthase	-	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
PYH3_k127_4788309_12	525904.Tter_0579	2.286e-41	158.0	COG0801@1|root,COG1469@1|root,COG0801@2|Bacteria,COG1469@2|Bacteria,2NPPF@2323|unclassified Bacteria	2|Bacteria	H	7 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase	folK	-	2.7.6.3,3.5.4.16,3.5.4.39,4.1.2.25	ko:K00950,ko:K09007,ko:K13940,ko:K17488	ko00790,ko01100,map00790,map01100	M00126,M00841	R00428,R03503,R03504,R04639,R05046,R05048,R10348	RC00002,RC00017,RC00263,RC00294,RC00323,RC00721,RC00943,RC00945,RC01188,RC02504,RC03131	ko00000,ko00001,ko00002,ko01000	-	-	-	FolB,HPPK
PYH3_k127_4788309_5	243164.DET0789	1.437e-73	255.0	COG1187@1|root,COG1187@2|Bacteria,2G6HU@200795|Chloroflexi,34D5B@301297|Dehalococcoidia	301297|Dehalococcoidia	J	RNA pseudouridylate synthase	-	-	5.4.99.22	ko:K06178	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
PYH3_k127_4788309_6	1429916.X566_15995	1.573e-62	225.0	COG1024@1|root,COG1024@2|Bacteria,1R3U7@1224|Proteobacteria,2TV9G@28211|Alphaproteobacteria,3JU2F@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
PYH3_k127_4788309_2	243164.DET0510	2.194e-170	547.0	COG1109@1|root,COG1109@2|Bacteria,2G5Y4@200795|Chloroflexi,34CP8@301297|Dehalococcoidia	301297|Dehalococcoidia	G	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III	-	-	5.4.2.8	ko:K01840	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01818	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
PYH3_k127_4788309_18	477974.Daud_0456	2.242e-21	100.0	COG0622@1|root,COG0622@2|Bacteria,1V7VB@1239|Firmicutes,2593B@186801|Clostridia,2628M@186807|Peptococcaceae	186801|Clostridia	S	TIGRFAM phosphoesterase, MJ0936 family	-	-	-	ko:K07095	-	-	-	-	ko00000	-	-	-	Metallophos_2
PYH3_k127_4788309_15	886379.AEWI01000014_gene1499	2.037e-30	121.0	COG1145@1|root,COG1145@2|Bacteria	2|Bacteria	C	4fe-4S ferredoxin, iron-sulfur binding domain protein	fdxB	-	-	ko:K03522,ko:K05337	-	-	-	-	ko00000,ko04147	-	-	-	Fer4,HTH_3,HTH_31
PYH3_k127_4788309_10	1382356.JQMP01000004_gene444	5.206e-47	175.0	COG0669@1|root,COG0669@2|Bacteria,2G6NZ@200795|Chloroflexi,27Y7C@189775|Thermomicrobia	189775|Thermomicrobia	F	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	-	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
PYH3_k127_4788309_8	552811.Dehly_1147	7.623e-60	212.0	COG0742@1|root,COG0742@2|Bacteria,2G6Y8@200795|Chloroflexi,34D0U@301297|Dehalococcoidia	301297|Dehalococcoidia	H	Conserved hypothetical protein 95	-	-	-	-	-	-	-	-	-	-	-	-	Cons_hypoth95
PYH3_k127_4788309_16	456442.Mboo_0387	5.237e-30	128.0	COG0491@1|root,arCOG00504@2157|Archaea,2XWX3@28890|Euryarchaeota,2NAZE@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM beta-lactamase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
PYH3_k127_4788309_1	552811.Dehly_0658	1.012e-207	654.0	COG0015@1|root,COG0015@2|Bacteria,2G607@200795|Chloroflexi,34CSN@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	purB	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
PYH3_k127_4788309_7	243164.DET0839	1.177e-60	213.0	COG0041@1|root,COG0041@2|Bacteria,2G6JS@200795|Chloroflexi,34CSG@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
PYH3_k127_4788309_3	255470.cbdbA819	5.207e-148	479.0	COG0151@1|root,COG0151@2|Bacteria,2G5ZE@200795|Chloroflexi,34CP9@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Phosphoribosylglycinamide synthetase, C domain	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
PYH3_k127_4788309_14	96561.Dole_2997	1.293e-32	128.0	COG2827@1|root,COG2827@2|Bacteria,1MZME@1224|Proteobacteria,42WQ3@68525|delta/epsilon subdivisions,2WS2E@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	GIY-YIG catalytic domain	-	-	-	ko:K07461	-	-	-	-	ko00000	-	-	-	GIY-YIG
PYH3_k127_4788309_0	552811.Dehly_0662	2.07e-269	839.0	COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,2G5WB@200795|Chloroflexi,34CZX@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Catalyzes the synthesis of GMP from XMP	guaA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
PYH3_k127_4788309_9	243164.DET0835	6.713e-51	188.0	COG0009@1|root,COG0009@2|Bacteria,2G673@200795|Chloroflexi,34CQJ@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Telomere recombination	-	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	Sua5_yciO_yrdC
PYH3_k127_4788309_11	1321778.HMPREF1982_01664	3.643e-43	162.0	COG0698@1|root,COG0698@2|Bacteria,1V3HE@1239|Firmicutes,24JWT@186801|Clostridia,268XB@186813|unclassified Clostridiales	186801|Clostridia	G	Ribose/Galactose Isomerase	rpiB	-	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	LacAB_rpiB
PYH3_k127_4788309_4	1101188.KI912155_gene2983	5.941e-82	288.0	COG1804@1|root,COG1804@2|Bacteria,2IB9E@201174|Actinobacteria	201174|Actinobacteria	C	L-carnitine dehydratase bile acid-inducible protein F	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
PYH3_k127_4788309_17	1123501.KB902276_gene1365	1.799e-23	103.0	COG1804@1|root,COG1804@2|Bacteria,1NSWZ@1224|Proteobacteria,2U2UE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
PYH3_k127_4800822_4	32042.PstZobell_04336	1.975e-05	47.0	COG2852@1|root,COG2852@2|Bacteria,1N0QU@1224|Proteobacteria,1S9F2@1236|Gammaproteobacteria,1Z30M@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF559
PYH3_k127_4800822_0	56780.SYN_01802	4.886e-101	344.0	COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,42MN3@68525|delta/epsilon subdivisions,2WMHC@28221|Deltaproteobacteria,2MQVK@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
PYH3_k127_4800822_1	368408.Tpen_1624	7.809e-56	204.0	COG3836@1|root,arCOG04974@2157|Archaea,2XRXT@28889|Crenarchaeota	28889|Crenarchaeota	G	HpcH/HpaI aldolase/citrate lyase family	-	-	4.1.2.20	ko:K01630	ko00053,map00053	-	R02754,R03277	RC00307,RC00435	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
PYH3_k127_4800822_2	118166.JH976538_gene5432	2.137e-38	149.0	COG0494@1|root,COG0494@2|Bacteria,1G5SE@1117|Cyanobacteria,1HBKS@1150|Oscillatoriales	1117|Cyanobacteria	L	pfam nudix	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
PYH3_k127_4800822_3	761193.Runsl_2088	4.96e-16	83.0	COG1983@1|root,COG1983@2|Bacteria,4NS0M@976|Bacteroidetes,47QMV@768503|Cytophagia	976|Bacteroidetes	KT	Putative auto-transporter adhesin, head GIN domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF2807
PYH3_k127_4875782_3	243164.DET0404	3.485e-37	144.0	COG0030@1|root,COG0030@2|Bacteria,2G6ER@200795|Chloroflexi,34CIF@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
PYH3_k127_4875782_0	552811.Dehly_1459	8.126e-225	709.0	COG0433@1|root,COG0433@2|Bacteria,2G62A@200795|Chloroflexi,34D7P@301297|Dehalococcoidia	301297|Dehalococcoidia	S	AAA-like domain	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF87,HAS-barrel
PYH3_k127_4875782_2	255470.cbdbA267	1.972e-52	191.0	2C7F0@1|root,2Z832@2|Bacteria,2G715@200795|Chloroflexi,34CQZ@301297|Dehalococcoidia	301297|Dehalococcoidia	S	PFAM HAS barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_4875782_1	311424.DhcVS_270	3.992e-91	311.0	COG1630@1|root,COG1630@2|Bacteria,2G68Z@200795|Chloroflexi,34CS5@301297|Dehalococcoidia	301297|Dehalococcoidia	S	NurA	-	-	-	-	-	-	-	-	-	-	-	-	NurA
PYH3_k127_4881725_0	439235.Dalk_0125	8.494e-143	466.0	COG2006@1|root,COG2006@2|Bacteria	2|Bacteria	U	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1,CBM9_2,DUF362
PYH3_k127_4881725_2	1232410.KI421413_gene766	1.815e-82	280.0	COG1145@1|root,COG1145@2|Bacteria,1PW12@1224|Proteobacteria,42MZ9@68525|delta/epsilon subdivisions,2WN0W@28221|Deltaproteobacteria,43SWA@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_6
PYH3_k127_4881725_7	552811.Dehly_0827	4.21e-29	118.0	2EGSE@1|root,33AII@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_4881725_4	552811.Dehly_0828	2.709e-62	222.0	COG0664@1|root,COG0664@2|Bacteria,2G70E@200795|Chloroflexi	200795|Chloroflexi	K	helix_turn_helix, cAMP Regulatory protein	-	-	-	ko:K21564	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
PYH3_k127_4881725_1	1125863.JAFN01000001_gene434	7.262e-139	464.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,42PDA@68525|delta/epsilon subdivisions,2WK05@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	NADH flavin oxidoreductase NADH oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN,Pyr_redox_2
PYH3_k127_4881725_8	311424.DhcVS_1514	6.428e-26	108.0	COG0694@1|root,COG0694@2|Bacteria,2G7BS@200795|Chloroflexi,34DGF@301297|Dehalococcoidia	301297|Dehalococcoidia	O	NifU-like domain	-	-	-	-	-	-	-	-	-	-	-	-	NifU
PYH3_k127_4881725_3	868131.MSWAN_1874	1.708e-78	269.0	COG2041@1|root,arCOG00266@2157|Archaea	2157|Archaea	P	COG2041 Sulfite oxidase and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB,Oxidored_molyb
PYH3_k127_4881725_6	1121422.AUMW01000002_gene2121	1.626e-40	152.0	COG1917@1|root,COG1917@2|Bacteria,1UHAE@1239|Firmicutes,24C81@186801|Clostridia	186801|Clostridia	S	Cupin domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
PYH3_k127_4881725_9	1449063.JMLS01000007_gene3386	1.553e-25	110.0	COG4430@1|root,COG4430@2|Bacteria,1VJJF@1239|Firmicutes,4IRZ2@91061|Bacilli	91061|Bacilli	S	Bacteriocin-protection, YdeI or OmpD-Associated	-	-	-	-	-	-	-	-	-	-	-	-	OmdA
PYH3_k127_4881725_5	1128421.JAGA01000003_gene3596	4.55e-56	203.0	COG0745@1|root,COG0745@2|Bacteria,2NR2D@2323|unclassified Bacteria	2|Bacteria	T	Transcriptional regulatory protein, C terminal	-	-	-	ko:K07667	ko02020,ko02024,map02020,map02024	M00454	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
PYH3_k127_4883575_14	96561.Dole_3249	2.539e-20	93.0	COG0709@1|root,COG0709@2|Bacteria,1MWFG@1224|Proteobacteria,42MC3@68525|delta/epsilon subdivisions,2WK3M@28221|Deltaproteobacteria,2MIG0@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Synthesizes selenophosphate from selenide and ATP	selD	-	2.7.9.3	ko:K01008	ko00450,ko01100,map00450,map01100	-	R03595	RC00002,RC02878	ko00000,ko00001,ko01000,ko03016	-	-	-	AIRS,AIRS_C
PYH3_k127_4883575_13	525909.Afer_1991	4.832e-50	189.0	COG0491@1|root,COG0491@2|Bacteria,2I9GW@201174|Actinobacteria,4CNHS@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
PYH3_k127_4883575_10	1262449.CP6013_1396	4.627e-59	210.0	COG0778@1|root,COG0778@2|Bacteria,1V4ZI@1239|Firmicutes,24BD0@186801|Clostridia,36H2X@31979|Clostridiaceae	186801|Clostridia	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
PYH3_k127_4883575_8	909663.KI867150_gene1576	9.397e-85	287.0	COG2043@1|root,COG2043@2|Bacteria,1R8EH@1224|Proteobacteria,42Q2F@68525|delta/epsilon subdivisions,2WJZN@28221|Deltaproteobacteria,2MQKY@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Uncharacterised ArCR, COG2043	-	-	-	-	-	-	-	-	-	-	-	-	DUF169
PYH3_k127_4883575_9	485916.Dtox_1959	6.537e-68	237.0	COG2109@1|root,COG2109@2|Bacteria,1V70U@1239|Firmicutes,24JNB@186801|Clostridia	186801|Clostridia	H	ATP corrinoid adenosyltransferase BtuR CobO CobP	cobO	-	2.5.1.17	ko:K19221	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	CobA_CobO_BtuR
PYH3_k127_4883575_11	269797.Mbar_A2036	2.342e-58	213.0	COG1497@1|root,arCOG04399@2157|Archaea,2XU16@28890|Euryarchaeota,2N9I6@224756|Methanomicrobia	224756|Methanomicrobia	K	SMART regulatory protein, Crp	-	-	-	ko:K07730	-	-	-	-	ko00000,ko03000	-	-	-	HTH_24,MarR_2
PYH3_k127_4883575_7	1089553.Tph_c03410	7.917e-99	335.0	COG0614@1|root,COG0614@2|Bacteria,1TQ4U@1239|Firmicutes,249I2@186801|Clostridia,42GA4@68295|Thermoanaerobacterales	186801|Clostridia	P	Periplasmic binding protein	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
PYH3_k127_4883575_5	1089553.Tph_c03420	2.859e-111	370.0	COG0609@1|root,COG0609@2|Bacteria,1TQXW@1239|Firmicutes,249TJ@186801|Clostridia,42GJN@68295|Thermoanaerobacterales	186801|Clostridia	P	FecCD transport family	btuC	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
PYH3_k127_4883575_3	760568.Desku_2192	9.045e-126	414.0	COG1120@1|root,COG1120@2|Bacteria,1TP2Q@1239|Firmicutes,2492Z@186801|Clostridia,264S1@186807|Peptococcaceae	186801|Clostridia	HP	ATPases associated with a variety of cellular activities	fepC	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran,zf-like
PYH3_k127_4883575_6	935948.KE386494_gene433	4.163e-102	347.0	COG2461@1|root,COG2461@2|Bacteria,1TRD5@1239|Firmicutes,24CKX@186801|Clostridia,42FM8@68295|Thermoanaerobacterales	186801|Clostridia	S	Family of unknown function (DUF438)	-	-	-	ko:K09155	-	-	-	-	ko00000	-	-	-	DUF1858,DUF438,Hemerythrin,PAS_10
PYH3_k127_4883575_16	246194.CHY_1295	1.694e-05	53.0	arCOG10401@1|root,2ZA7Y@2|Bacteria,1V3TD@1239|Firmicutes,24I7A@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_4883575_1	383372.Rcas_1889	9.232e-129	421.0	COG1960@1|root,COG1960@2|Bacteria,2G8BF@200795|Chloroflexi,3763I@32061|Chloroflexia	32061|Chloroflexia	C	PFAM acyl-CoA dehydrogenase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
PYH3_k127_4883575_0	316274.Haur_0958	1.043e-139	455.0	COG1960@1|root,COG1960@2|Bacteria,2G6E5@200795|Chloroflexi,3763W@32061|Chloroflexia	32061|Chloroflexia	C	PFAM acyl-CoA dehydrogenase domain protein	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
PYH3_k127_4883575_4	999630.TUZN_0689	7.025e-123	406.0	COG0183@1|root,arCOG01282@2157|Archaea,2XQ3F@28889|Crenarchaeota	28889|Crenarchaeota	I	Beta-ketoacyl synthase, N-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
PYH3_k127_4883575_2	768679.TTX_1029	4.158e-126	415.0	COG0183@1|root,arCOG01282@2157|Archaea,2XQ3F@28889|Crenarchaeota	28889|Crenarchaeota	I	Beta-ketoacyl synthase, N-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
PYH3_k127_4883575_15	1230341.MJ3_07528	5.014e-08	61.0	COG1514@1|root,COG1514@2|Bacteria,1V2F3@1239|Firmicutes,4HG6P@91061|Bacilli	91061|Bacilli	J	Belongs to the 2H phosphoesterase superfamily. YjcG family	yjcG	-	-	-	-	-	-	-	-	-	-	-	2_5_RNA_ligase2
PYH3_k127_4883575_12	1382306.JNIM01000001_gene274	2.657e-56	198.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,2G6X3@200795|Chloroflexi	200795|Chloroflexi	H	NAD synthase	-	-	6.3.1.5	ko:K01916	ko00760,ko01100,map00760,map01100	M00115	R00189	RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	NAD_synthase
PYH3_k127_4886445_5	316274.Haur_1889	3.571e-25	111.0	COG0842@1|root,COG0842@2|Bacteria,2G8VC@200795|Chloroflexi	200795|Chloroflexi	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
PYH3_k127_4886445_1	316067.Geob_1415	3.889e-69	246.0	COG1600@1|root,COG1600@2|Bacteria,1RAYI@1224|Proteobacteria,42R4W@68525|delta/epsilon subdivisions,2WK0B@28221|Deltaproteobacteria,43S8Y@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_4886445_4	1449126.JQKL01000019_gene3210	3.12e-41	162.0	COG1028@1|root,COG1028@2|Bacteria,1UETI@1239|Firmicutes,24M1T@186801|Clostridia,26BHA@186813|unclassified Clostridiales	186801|Clostridia	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.69	ko:K00046	-	-	-	-	ko00000,ko01000	-	-	-	adh_short_C2
PYH3_k127_4886445_3	350054.Mflv_1263	3.548e-52	194.0	COG1028@1|root,COG1028@2|Bacteria,2GJU1@201174|Actinobacteria,236CE@1762|Mycobacteriaceae	201174|Actinobacteria	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
PYH3_k127_4886445_2	867903.ThesuDRAFT_01144	1.323e-63	226.0	COG1028@1|root,COG1028@2|Bacteria,1TR53@1239|Firmicutes,247XS@186801|Clostridia	186801|Clostridia	IQ	Dehydrogenase	ydaD	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
PYH3_k127_4886445_6	698769.JFBD01000042_gene814	1.318e-11	67.0	2DR03@1|root,339MB@2|Bacteria,1VK6Y@1239|Firmicutes,4HR34@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_4886445_0	255470.cbdbA1039	8.783e-164	555.0	COG4166@1|root,COG4166@2|Bacteria,2G81T@200795|Chloroflexi,34DKF@301297|Dehalococcoidia	301297|Dehalococcoidia	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	SBP_bac_5
PYH3_k127_49923_2	926569.ANT_16770	2.099e-07	53.0	COG0341@1|root,COG0341@2|Bacteria,2G696@200795|Chloroflexi	200795|Chloroflexi	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	-	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
PYH3_k127_49923_0	552811.Dehly_0091	3.806e-78	272.0	COG0053@1|root,COG0053@2|Bacteria,2G5MK@200795|Chloroflexi,34CPI@301297|Dehalococcoidia	301297|Dehalococcoidia	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
PYH3_k127_49923_1	552811.Dehly_1384	2.385e-70	243.0	COG1280@1|root,COG1280@2|Bacteria,2GBTY@200795|Chloroflexi,34CQW@301297|Dehalococcoidia	301297|Dehalococcoidia	E	LysE type translocator	-	-	-	-	-	-	-	-	-	-	-	-	LysE
PYH3_k127_5033846_7	318996.AXAZ01000024_gene2295	3.794e-05	56.0	COG2931@1|root,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF4114,HemolysinCabind,Lectin_legB,VCBS,VPEP
PYH3_k127_5033846_1	552811.Dehly_0618	4.251e-115	382.0	COG0809@1|root,COG0809@2|Bacteria,2G5UZ@200795|Chloroflexi,34D9Q@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	queA	-	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
PYH3_k127_5033846_3	1382306.JNIM01000001_gene2563	1.286e-89	311.0	COG1058@1|root,COG1058@2|Bacteria,2G6DU@200795|Chloroflexi	200795|Chloroflexi	S	PFAM molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	CinA,MoCF_biosynth
PYH3_k127_5033846_2	489825.LYNGBM3L_18580	7.224e-103	342.0	COG2017@1|root,COG3386@1|root,COG2017@2|Bacteria,COG3386@2|Bacteria,1G05C@1117|Cyanobacteria,1H9TR@1150|Oscillatoriales	1117|Cyanobacteria	G	PFAM SMP-30 Gluconolaconase LRE-like region	-	-	3.1.1.17	ko:K01053	ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02933,R03751	RC00537,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	SGL
PYH3_k127_5033846_4	552811.Dehly_1173	1.825e-30	130.0	COG1286@1|root,COG1286@2|Bacteria,2G9GY@200795|Chloroflexi,34CZ1@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Colicin V production protein	-	-	-	ko:K03558	-	-	-	-	ko00000	-	-	-	Colicin_V
PYH3_k127_5033846_0	335543.Sfum_0797	5.233e-188	607.0	COG0633@1|root,COG3894@1|root,COG0633@2|Bacteria,COG3894@2|Bacteria,1MV6C@1224|Proteobacteria,42MF5@68525|delta/epsilon subdivisions,2WKC6@28221|Deltaproteobacteria,2MQU1@213462|Syntrophobacterales	68525|delta/epsilon subdivisions	C	PFAM 2Fe-2S iron-sulfur cluster binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
PYH3_k127_5033846_5	1521187.JPIM01000001_gene857	9.757e-20	96.0	COG0589@1|root,COG0589@2|Bacteria	2|Bacteria	T	AMP binding	-	-	-	-	-	-	-	-	-	-	-	-	CBS,Usp
PYH3_k127_5033846_6	682795.AciX8_1804	1.159e-18	91.0	COG0534@1|root,COG0534@2|Bacteria,3Y6HQ@57723|Acidobacteria	57723|Acidobacteria	V	PFAM multi antimicrobial extrusion protein	-	-	-	-	-	-	-	-	-	-	-	-	MatE
PYH3_k127_5059647_2	1121396.KB893128_gene4403	5.445e-43	168.0	COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,42R03@68525|delta/epsilon subdivisions,2WMTZ@28221|Deltaproteobacteria,2MJ7X@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
PYH3_k127_5059647_3	926569.ANT_19700	4.978e-33	135.0	COG1238@1|root,COG1238@2|Bacteria,2G932@200795|Chloroflexi	200795|Chloroflexi	S	PFAM SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
PYH3_k127_5059647_7	1347087.CBYO010000022_gene3568	0.0009183	48.0	2DM0T@1|root,317RV@2|Bacteria,1V7JH@1239|Firmicutes,4HJ2E@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_5059647_1	243164.DET0105	3.812e-65	232.0	COG1307@1|root,COG1307@2|Bacteria,2G6P2@200795|Chloroflexi,34CU6@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Uncharacterised protein, DegV family COG1307	-	-	-	-	-	-	-	-	-	-	-	-	DegV
PYH3_k127_5059647_0	243164.DET1263	3.539e-139	462.0	COG1461@1|root,COG1461@2|Bacteria,2G61Z@200795|Chloroflexi,34CPP@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Dak1_2	-	-	-	ko:K07030	-	-	-	-	ko00000	-	-	-	Dak1_2,Dak2
PYH3_k127_5059647_5	658612.MD26_21435	2.085e-05	55.0	28KNE@1|root,2ZA6M@2|Bacteria,1R499@1224|Proteobacteria,1RZKQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF998)	-	-	-	-	-	-	-	-	-	-	-	-	DUF998
PYH3_k127_5059647_6	255470.cbdbA1487	8.963e-05	47.0	COG2801@1|root,COG2801@2|Bacteria,2G8GQ@200795|Chloroflexi,34DDP@301297|Dehalococcoidia	301297|Dehalococcoidia	L	PFAM Integrase catalytic region	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
PYH3_k127_5059647_4	452637.Oter_0563	2.265e-07	54.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	eryCVI	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0009058,GO:0009987,GO:0016740,GO:0016741,GO:0016999,GO:0017000,GO:0017144,GO:0032259,GO:0042802,GO:0042803,GO:0044237,GO:0044249,GO:0046983	2.1.1.234	ko:K13311,ko:K13326,ko:K21335	ko00523,ko01130,map00523,map01130	M00797,M00800	R06427,R11045,R11476	RC00003,RC01515,RC02262	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_25
PYH3_k127_5060238_1	243164.DET0967	9.526e-170	543.0	COG0514@1|root,COG1205@1|root,COG0514@2|Bacteria,COG1205@2|Bacteria,2G605@200795|Chloroflexi,34CMG@301297|Dehalococcoidia	301297|Dehalococcoidia	L	Domain of unknown function (DUF1998)	-	-	-	ko:K06877	-	-	-	-	ko00000	-	-	-	DEAD,DUF1998,Helicase_C
PYH3_k127_5060238_3	243164.DET0966	3.968e-69	244.0	COG0682@1|root,COG0682@2|Bacteria,2G78M@200795|Chloroflexi,34D5E@301297|Dehalococcoidia	301297|Dehalococcoidia	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
PYH3_k127_5060238_2	933262.AXAM01000005_gene2470	2.946e-125	414.0	COG0183@1|root,COG0183@2|Bacteria,1MU8C@1224|Proteobacteria,42N6X@68525|delta/epsilon subdivisions,2WJIE@28221|Deltaproteobacteria,2MK14@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Thiolase, C-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
PYH3_k127_5060238_4	933262.AXAM01000005_gene2471	3.904e-29	123.0	COG1545@1|root,COG1545@2|Bacteria,1NPAR@1224|Proteobacteria,42WW8@68525|delta/epsilon subdivisions,2WSYD@28221|Deltaproteobacteria,2MM8Q@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Rubredoxin-like zinc ribbon domain (DUF35_N)	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
PYH3_k127_5060238_0	552811.Dehly_0760	2.496e-272	850.0	COG1217@1|root,COG1217@2|Bacteria,2G5NQ@200795|Chloroflexi,34D8B@301297|Dehalococcoidia	301297|Dehalococcoidia	T	Elongation factor G C-terminus	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
PYH3_k127_5063831_16	1122915.AUGY01000086_gene6108	3.734e-30	125.0	COG0523@1|root,COG0523@2|Bacteria,1TPCG@1239|Firmicutes,4HCYE@91061|Bacilli,26QVQ@186822|Paenibacillaceae	91061|Bacilli	S	Cobalamin synthesis protein cobW C-terminal domain	COBW3	-	-	-	-	-	-	-	-	-	-	-	CobW_C,cobW
PYH3_k127_5063831_6	255470.cbdbA860	1.158e-88	309.0	COG2211@1|root,COG2211@2|Bacteria,2G6WX@200795|Chloroflexi,34CJ4@301297|Dehalococcoidia	301297|Dehalococcoidia	G	MFS_1 like family	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
PYH3_k127_5063831_9	439235.Dalk_5191	8.162e-74	266.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,42NTV@68525|delta/epsilon subdivisions,2WJTP@28221|Deltaproteobacteria,2MIWR@213118|Desulfobacterales	1224|Proteobacteria	C	PFAM CoA-binding domain protein	MA20_15065	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
PYH3_k127_5063831_15	1120949.KB903357_gene5007	5.42e-32	134.0	COG0420@1|root,COG0420@2|Bacteria	2|Bacteria	L	3'-5' exonuclease activity	sbcD	-	-	ko:K03547	-	-	-	-	ko00000,ko03400	-	-	-	Metallophos,SbcD_C
PYH3_k127_5063831_12	909663.KI867149_gene3220	1.609e-69	245.0	COG2003@1|root,COG2003@2|Bacteria,1MXZ5@1224|Proteobacteria,42PPW@68525|delta/epsilon subdivisions,2WM1S@28221|Deltaproteobacteria,2MQKV@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	RadC-like JAB domain	radC	-	-	ko:K03630	-	-	-	-	ko00000	-	-	-	RadC
PYH3_k127_5063831_5	243164.DET0571	6.32e-99	337.0	COG0308@1|root,COG0308@2|Bacteria,2G6SD@200795|Chloroflexi,34D27@301297|Dehalococcoidia	301297|Dehalococcoidia	E	Peptidase MA superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_MA_2
PYH3_k127_5063831_3	311424.DhcVS_509	3.85e-143	462.0	COG1186@1|root,COG1186@2|Bacteria,2G5P6@200795|Chloroflexi,34CN2@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
PYH3_k127_5063831_11	243164.DET0569	8.442e-70	244.0	COG1515@1|root,COG1515@2|Bacteria,2G6SS@200795|Chloroflexi,34D8S@301297|Dehalococcoidia	301297|Dehalococcoidia	L	DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA	nfi	-	3.1.21.7	ko:K05982	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Endonuclease_5
PYH3_k127_5063831_2	255470.cbdbA554	4.951e-173	552.0	COG0172@1|root,COG0172@2|Bacteria,2G5PD@200795|Chloroflexi,34CX1@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
PYH3_k127_5063831_0	243164.DET0578	4.669e-180	577.0	COG1190@1|root,COG1190@2|Bacteria,2G65Z@200795|Chloroflexi,34CKJ@301297|Dehalococcoidia	301297|Dehalococcoidia	J	lysyl-tRNA aminoacylation	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
PYH3_k127_5063831_10	311424.DhcVS_519	1.098e-71	251.0	COG1381@1|root,COG1381@2|Bacteria,2G6N7@200795|Chloroflexi,34CSZ@301297|Dehalococcoidia	301297|Dehalococcoidia	L	Involved in DNA repair and RecF pathway recombination	recO	-	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
PYH3_k127_5063831_13	1123242.JH636435_gene2937	9.16e-67	236.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25,Methyltransf_31
PYH3_k127_5063831_7	1380394.JADL01000002_gene1665	4.168e-83	285.0	COG0627@1|root,COG0627@2|Bacteria,1R4M6@1224|Proteobacteria,2U4X7@28211|Alphaproteobacteria,2JXF4@204441|Rhodospirillales	204441|Rhodospirillales	S	Putative esterase	-	-	-	ko:K07214	-	-	-	-	ko00000	-	-	-	Esterase
PYH3_k127_5063831_4	246194.CHY_0193	1.66e-99	334.0	COG0462@1|root,COG0462@2|Bacteria,1TQ6Q@1239|Firmicutes,248ZN@186801|Clostridia,42EXR@68295|Thermoanaerobacterales	186801|Clostridia	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
PYH3_k127_5063831_8	552811.Dehly_0463	9.198e-77	262.0	COG0353@1|root,COG0353@2|Bacteria,2G6CT@200795|Chloroflexi,34D3R@301297|Dehalococcoidia	301297|Dehalococcoidia	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	-	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecR,Toprim_4
PYH3_k127_5063831_18	744985.HIMB59_00002290	2.346e-16	82.0	COG0718@1|root,COG0718@2|Bacteria,1RGZD@1224|Proteobacteria,2UBQB@28211|Alphaproteobacteria,4BQZ0@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection	ybaB	-	-	ko:K09747	-	-	-	-	ko00000	-	-	-	YbaB_DNA_bd
PYH3_k127_5063831_1	243164.DET0585	6.499e-174	561.0	COG2812@1|root,COG2812@2|Bacteria,2G5PK@200795|Chloroflexi,34CSC@301297|Dehalococcoidia	301297|Dehalococcoidia	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
PYH3_k127_5063831_17	1382304.JNIL01000001_gene1083	1.098e-16	82.0	COG1193@1|root,COG1193@2|Bacteria,1TP5W@1239|Firmicutes,4H9NZ@91061|Bacilli,277ZP@186823|Alicyclobacillaceae	91061|Bacilli	L	Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity	mutS2	GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391	-	ko:K07456	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_V,Smr
PYH3_k127_5063831_14	255470.cbdbA994	7.496e-60	216.0	COG0571@1|root,COG0571@2|Bacteria,2G6PD@200795|Chloroflexi,34D6R@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	rnc	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
PYH3_k127_5063831_19	1429916.X566_03925	2.568e-05	49.0	COG0747@1|root,COG0747@2|Bacteria,1PFW6@1224|Proteobacteria,2U1GT@28211|Alphaproteobacteria,3JUHW@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Peptide ABC transporter substrate-binding protein	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
PYH3_k127_5081342_2	994573.T472_0204210	4.313e-47	175.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,36FZW@31979|Clostridiaceae	186801|Clostridia	C	Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
PYH3_k127_5081342_3	1323663.AROI01000035_gene1343	8.514e-22	98.0	2CJ4Q@1|root,32S97@2|Bacteria,1N0B9@1224|Proteobacteria,1S97T@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	ethyl tert-butyl ether degradation	ethD	-	-	-	-	-	-	-	-	-	-	-	EthD
PYH3_k127_5081342_1	868131.MSWAN_0242	4.329e-49	183.0	COG0491@1|root,arCOG00504@2157|Archaea,2XWX3@28890|Euryarchaeota	28890|Euryarchaeota	S	COG0491 Zn-dependent hydrolases, including glyoxylases	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
PYH3_k127_5081342_0	1125973.JNLC01000010_gene1417	1.316e-153	500.0	COG2936@1|root,COG2936@2|Bacteria,1MVA8@1224|Proteobacteria,2TU0R@28211|Alphaproteobacteria,3JZ96@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
PYH3_k127_5081342_4	1216362.B437_07567	0.0003135	50.0	COG0747@1|root,COG0747@2|Bacteria,3785F@32066|Fusobacteria	32066|Fusobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
PYH3_k127_5195110_4	44251.PDUR_13945	1.262e-115	384.0	COG0641@1|root,COG0641@2|Bacteria,1TQPS@1239|Firmicutes,4HEMS@91061|Bacilli,26RUR@186822|Paenibacillaceae	91061|Bacilli	C	Iron-sulfur cluster-binding domain	ydeM3	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SEC-C,SPASM
PYH3_k127_5195110_6	1429916.X566_16655	1.183e-67	246.0	COG2015@1|root,COG2015@2|Bacteria,1MU82@1224|Proteobacteria,2TSM1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG2015, Alkyl sulfatase and related hydrolases	-	-	-	-	-	-	-	-	-	-	-	-	Alkyl_sulf_dimr,Lactamase_B
PYH3_k127_5195110_2	706587.Desti_2022	2.372e-130	426.0	COG1680@1|root,COG1680@2|Bacteria,1QD0J@1224|Proteobacteria,42Y9Q@68525|delta/epsilon subdivisions,2WTQX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
PYH3_k127_5195110_9	1121405.dsmv_3288	1.802e-31	126.0	COG0724@1|root,COG0724@2|Bacteria,1N6VR@1224|Proteobacteria,42UQP@68525|delta/epsilon subdivisions,2WQKU@28221|Deltaproteobacteria,2MMAC@213118|Desulfobacterales	28221|Deltaproteobacteria	S	RNA recognition motif	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
PYH3_k127_5195110_7	1448389.BAVQ01000002_gene2863	2.442e-58	211.0	2DBMA@1|root,2Z9Y3@2|Bacteria,2I9ER@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF4389)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4389
PYH3_k127_5195110_3	255470.cbdbA691	1.67e-127	418.0	COG2262@1|root,COG2262@2|Bacteria,2G634@200795|Chloroflexi,34D24@301297|Dehalococcoidia	301297|Dehalococcoidia	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
PYH3_k127_5195110_1	909663.KI867150_gene1212	1.084e-174	555.0	COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,42NH6@68525|delta/epsilon subdivisions,2WJCV@28221|Deltaproteobacteria,2MSIE@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	Aminotransferase class I and II	dapL	GO:0003674,GO:0003824,GO:0008483,GO:0016740,GO:0016769	2.6.1.83	ko:K10206	ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230	M00527	R07613	RC00006,RC01847	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
PYH3_k127_5195110_5	350054.Mflv_4116	6.561e-87	302.0	COG1804@1|root,COG1804@2|Bacteria,2GRB0@201174|Actinobacteria,235AT@1762|Mycobacteriaceae	201174|Actinobacteria	C	PFAM CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
PYH3_k127_5195110_8	1197906.CAJQ02000038_gene4688	1.154e-44	178.0	COG0477@1|root,COG2814@2|Bacteria,1MVHG@1224|Proteobacteria,2TWR2@28211|Alphaproteobacteria,3JVDD@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
PYH3_k127_5195110_10	1499680.CCFE01000016_gene1005	1.449e-10	66.0	COG2002@1|root,COG2002@2|Bacteria,1UW6P@1239|Firmicutes,4HZHD@91061|Bacilli,1ZI0K@1386|Bacillus	91061|Bacilli	K	SpoVT / AbrB like domain	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin
PYH3_k127_5195110_0	552811.Dehly_1606	6.843e-218	710.0	COG0841@1|root,COG0841@2|Bacteria,2G68V@200795|Chloroflexi,34D3K@301297|Dehalococcoidia	301297|Dehalococcoidia	V	AcrB/AcrD/AcrF family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
PYH3_k127_5238143_0	649831.L083_3500	1.028e-44	176.0	COG3629@1|root,COG3629@2|Bacteria,2I5I3@201174|Actinobacteria	201174|Actinobacteria	K	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,Trans_reg_C
PYH3_k127_5238143_1	63737.Npun_R1092	2.717e-31	138.0	28IIQ@1|root,2Z8JR@2|Bacteria,1G18P@1117|Cyanobacteria,1HP2J@1161|Nostocales	1117|Cyanobacteria	S	Domain of unknown function (DUF4159)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4159
PYH3_k127_5238143_3	1343740.M271_05170	5.356e-11	76.0	COG1470@1|root,COG1470@2|Bacteria,2H4ZH@201174|Actinobacteria	201174|Actinobacteria	E	Pkd domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1
PYH3_k127_5238143_2	749927.AMED_4828	6.949e-19	101.0	COG1470@1|root,COG1470@2|Bacteria,2H4ZH@201174|Actinobacteria,4E24A@85010|Pseudonocardiales	201174|Actinobacteria	S	cell adhesion involved in biofilm formation	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1
PYH3_k127_5253746_0	243164.DET1432	2.329e-125	409.0	COG0068@1|root,COG0068@2|Bacteria,2G5QN@200795|Chloroflexi,34CJB@301297|Dehalococcoidia	301297|Dehalococcoidia	O	Telomere recombination	hypF	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
PYH3_k127_5253746_7	335543.Sfum_2805	1.075e-13	79.0	COG0509@1|root,COG0509@2|Bacteria,1Q1KI@1224|Proteobacteria,437BG@68525|delta/epsilon subdivisions,2X2GI@28221|Deltaproteobacteria,2MRJR@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	PFAM glycine cleavage H-protein	-	-	-	-	-	-	-	-	-	-	-	-	GCV_H
PYH3_k127_5253746_3	243164.DET0663	1.104e-84	286.0	COG2197@1|root,COG2197@2|Bacteria,2G6T1@200795|Chloroflexi,34CJY@301297|Dehalococcoidia	301297|Dehalococcoidia	K	Bacterial regulatory proteins, luxR family	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
PYH3_k127_5253746_4	311424.DhcVS_600	7.483e-70	258.0	COG4585@1|root,COG4585@2|Bacteria,2G8PE@200795|Chloroflexi,34CQA@301297|Dehalococcoidia	301297|Dehalococcoidia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
PYH3_k127_5253746_2	1121035.AUCH01000008_gene965	2.976e-104	351.0	COG0002@1|root,COG0002@2|Bacteria,1MVJ6@1224|Proteobacteria,2VJD7@28216|Betaproteobacteria,2KUPE@206389|Rhodocyclales	206389|Rhodocyclales	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	-	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh
PYH3_k127_5253746_6	439235.Dalk_1627	1.02e-45	173.0	COG1014@1|root,COG1014@2|Bacteria,1R8XG@1224|Proteobacteria,42NPD@68525|delta/epsilon subdivisions,2WMQ1@28221|Deltaproteobacteria,2MJP0@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	-	-	1.2.7.3	ko:K00177	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
PYH3_k127_5253746_1	1379698.RBG1_1C00001G0036	9.876e-105	347.0	COG1013@1|root,COG1013@2|Bacteria,2NPAM@2323|unclassified Bacteria	2|Bacteria	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFO_beta_C,TPP_enzyme_C
PYH3_k127_5253746_5	1049564.TevJSym_az00290	1.546e-61	216.0	COG0674@1|root,COG0674@2|Bacteria,1NBSJ@1224|Proteobacteria,1S0WV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
PYH3_k127_5263488_14	370438.PTH_2811	2.303e-18	86.0	COG0355@1|root,COG0355@2|Bacteria,1VA89@1239|Firmicutes,24ND7@186801|Clostridia,2629N@186807|Peptococcaceae	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	iHN637.CLJU_RS01195	ATP-synt_DE,ATP-synt_DE_N
PYH3_k127_5263488_3	177437.HRM2_37410	3.956e-167	535.0	COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,42KZH@68525|delta/epsilon subdivisions,2WIRM@28221|Deltaproteobacteria,2MI6R@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Pyridoxal-dependent decarboxylase, pyridoxal binding domain	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
PYH3_k127_5263488_6	1321778.HMPREF1982_00886	2.51e-75	261.0	COG0778@1|root,COG0778@2|Bacteria,1UB8S@1239|Firmicutes,249SD@186801|Clostridia,268FR@186813|unclassified Clostridiales	186801|Clostridia	C	Nitroreductase family	-	-	1.5.1.38	ko:K19285	ko00740,ko01100,map00740,map01100	-	R05706	RC00126	ko00000,ko00001,ko01000	-	-	-	Nitroreductase
PYH3_k127_5263488_1	391735.Veis_4961	2.359e-213	677.0	COG0318@1|root,COG0318@2|Bacteria,1MUMC@1224|Proteobacteria,2VGZE@28216|Betaproteobacteria	28216|Betaproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
PYH3_k127_5263488_0	243164.DET1196	3.62e-280	880.0	COG0210@1|root,COG0210@2|Bacteria,2G5XF@200795|Chloroflexi,34D7Z@301297|Dehalococcoidia	301297|Dehalococcoidia	L	UvrD/REP helicase N-terminal domain	pcrA	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
PYH3_k127_5263488_5	391623.TERMP_01959	2.735e-117	385.0	COG0863@1|root,arCOG00115@2157|Archaea,2Y6KV@28890|Euryarchaeota,244UT@183968|Thermococci	183968|Thermococci	L	DNA methylase	-	-	2.1.1.113,2.1.1.72	ko:K00571,ko:K00590	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
PYH3_k127_5263488_4	311424.DhcVS_978	5.372e-163	532.0	COG0323@1|root,COG0323@2|Bacteria,2G5XU@200795|Chloroflexi,34CP3@301297|Dehalococcoidia	301297|Dehalococcoidia	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	-	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
PYH3_k127_5263488_15	255470.cbdbA1099	5.399e-16	82.0	2BQBB@1|root,32J6D@2|Bacteria,2GAWR@200795|Chloroflexi,34DHV@301297|Dehalococcoidia	301297|Dehalococcoidia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_5263488_2	255470.cbdbA1050	6.241e-195	616.0	COG0174@1|root,COG0174@2|Bacteria,2G5U2@200795|Chloroflexi,34CUT@301297|Dehalococcoidia	301297|Dehalococcoidia	E	Glutamine synthetase, catalytic domain	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
PYH3_k127_5263488_7	1168034.FH5T_17755	1.13e-50	197.0	COG0591@1|root,COG0591@2|Bacteria,4NH7H@976|Bacteroidetes	976|Bacteroidetes	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K03307,ko:K14387	ko04725,ko05231,map04725,map05231	-	-	-	ko00000,ko00001,ko02000	2.A.21,2.A.21.8	-	-	HD_4,SSF
PYH3_k127_5263488_8	243164.DET0323	9.424e-49	191.0	COG4974@1|root,COG4974@2|Bacteria	2|Bacteria	L	Belongs to the 'phage' integrase family	-	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Arm-DNA-bind_4,Phage_int_SAM_1,Phage_integrase
PYH3_k127_5263488_10	1499967.BAYZ01000080_gene893	3.887e-37	143.0	COG2944@1|root,COG2944@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	-	-	-	ko:K18830	-	-	-	-	ko00000,ko02048,ko03000	-	-	-	HTH_3,TIR_2
PYH3_k127_5263488_16	1002340.AFCF01000049_gene1510	0.0001703	53.0	COG2931@1|root,COG3291@1|root,COG2931@2|Bacteria,COG3291@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,34EIP@302485|Phaeobacter	28211|Alphaproteobacteria	Q	Hint domain	-	-	-	-	-	-	-	-	-	-	-	-	Hint_2
PYH3_k127_5263488_13	870187.Thini_3841	1.156e-20	98.0	2E3GU@1|root,32YFI@2|Bacteria,1NJ13@1224|Proteobacteria,1SI3B@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_5263488_11	1380347.JNII01000012_gene2672	7.372e-24	110.0	COG3064@1|root,COG3064@2|Bacteria,2I5UC@201174|Actinobacteria	201174|Actinobacteria	M	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF4389
PYH3_k127_5285764_14	1380394.JADL01000017_gene522	7.102e-46	169.0	COG1960@1|root,COG1960@2|Bacteria,1MVQH@1224|Proteobacteria,2TTX8@28211|Alphaproteobacteria,2JPUP@204441|Rhodospirillales	204441|Rhodospirillales	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
PYH3_k127_5285764_10	1500257.JQNM01000016_gene3112	5.59e-74	258.0	COG0500@1|root,COG2226@2|Bacteria,1R99I@1224|Proteobacteria,2VFEV@28211|Alphaproteobacteria,4BN94@82115|Rhizobiaceae	28211|Alphaproteobacteria	Q	Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
PYH3_k127_5285764_18	1246995.AFR_27115	1.597e-19	95.0	COG0454@1|root,COG0456@2|Bacteria,2IHRD@201174|Actinobacteria,4DER8@85008|Micromonosporales	201174|Actinobacteria	K	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
PYH3_k127_5285764_20	1207076.ALAT01000099_gene2331	3.689e-06	56.0	COG2761@1|root,COG2761@2|Bacteria,1RIE0@1224|Proteobacteria	1224|Proteobacteria	Q	DSBA-like thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	DSBA
PYH3_k127_5285764_7	56780.SYN_00998	1.696e-76	267.0	COG1032@1|root,COG1032@2|Bacteria,1PTN9@1224|Proteobacteria,42MG9@68525|delta/epsilon subdivisions,2WJYU@28221|Deltaproteobacteria,2MR0G@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
PYH3_k127_5285764_16	552811.Dehly_0300	2.956e-38	149.0	COG1399@1|root,COG1399@2|Bacteria,2G6Z5@200795|Chloroflexi,34DAR@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Uncharacterized ACR, COG1399	-	-	-	ko:K07040	-	-	-	-	ko00000	-	-	-	DUF177
PYH3_k127_5285764_19	243164.DET1275	1.179e-16	81.0	COG0333@1|root,COG0333@2|Bacteria,2G7EA@200795|Chloroflexi,34DHT@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Belongs to the bacterial ribosomal protein bL32 family	rpmF	-	-	ko:K02911	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_L32p
PYH3_k127_5285764_2	273068.TTE1474	2.168e-115	379.0	COG2070@1|root,COG2070@2|Bacteria,1TPC3@1239|Firmicutes,24831@186801|Clostridia,42F3W@68295|Thermoanaerobacterales	186801|Clostridia	S	enoyl-(acyl-carrier-protein) reductase II	fabK	-	1.3.1.9	ko:K02371	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00083	R04429,R04724,R04955,R04958,R04961,R04966,R04969,R07765	RC00052,RC00076	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	iHN637.CLJU_RS20775	NMO
PYH3_k127_5285764_4	311424.DhcVS_1059	6.883e-101	338.0	COG0331@1|root,COG0331@2|Bacteria,2G61W@200795|Chloroflexi,34D34@301297|Dehalococcoidia	301297|Dehalococcoidia	I	Acyl transferase domain	fabD	-	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
PYH3_k127_5285764_1	1293047.CBMA010000011_gene486	1.668e-121	409.0	COG0028@1|root,arCOG01998@2157|Archaea,2XUZI@28890|Euryarchaeota,23S8J@183963|Halobacteria	183963|Halobacteria	E	COG0028 Thiamine pyrophosphate-requiring enzymes acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase	ilvB3	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
PYH3_k127_5285764_12	1122915.AUGY01000020_gene6449	5.12e-65	235.0	COG1063@1|root,COG1063@2|Bacteria,1TPWP@1239|Firmicutes,4HAA0@91061|Bacilli,26UDT@186822|Paenibacillaceae	91061|Bacilli	E	Alcohol dehydrogenase GroES-like domain	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
PYH3_k127_5285764_11	887929.HMP0721_1981	9.215e-67	237.0	COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,24MEI@186801|Clostridia,25YQ8@186806|Eubacteriaceae	186801|Clostridia	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
PYH3_k127_5285764_0	926569.ANT_18640	0.0	1146.0	COG3808@1|root,COG3808@2|Bacteria,2G5N7@200795|Chloroflexi	200795|Chloroflexi	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
PYH3_k127_5285764_5	1444306.JFZC01000089_gene1408	5.898e-85	289.0	COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,4HAA6@91061|Bacilli,26N9U@186821|Sporolactobacillaceae	91061|Bacilli	IQ	PFAM short-chain dehydrogenase reductase SDR	fabG	GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	iYO844.BSU15910	adh_short_C2
PYH3_k127_5285764_15	311424.DhcVS_1061	1.862e-39	151.0	COG0781@1|root,COG0781@2|Bacteria,2G6XA@200795|Chloroflexi,34CUC@301297|Dehalococcoidia	301297|Dehalococcoidia	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
PYH3_k127_5285764_17	552811.Dehly_0305	1.846e-26	110.0	COG0236@1|root,COG0236@2|Bacteria,2G76M@200795|Chloroflexi,34DGE@301297|Dehalococcoidia	301297|Dehalococcoidia	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
PYH3_k127_5285764_13	243164.DET0533	2.263e-46	176.0	COG1011@1|root,COG1011@2|Bacteria,2G78N@200795|Chloroflexi,34D8N@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Haloacid dehalogenase-like hydrolase	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
PYH3_k127_5285764_9	326424.FRAAL3129	2.571e-75	269.0	COG1804@1|root,COG1804@2|Bacteria,2GRB0@201174|Actinobacteria	201174|Actinobacteria	C	L-carnitine dehydratase bile acid-inducible protein F	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
PYH3_k127_5285764_6	1172185.KB911532_gene64	2.047e-79	281.0	COG1804@1|root,COG1804@2|Bacteria,2GRB0@201174|Actinobacteria,4FW2K@85025|Nocardiaceae	201174|Actinobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
PYH3_k127_5285764_3	1243664.CAVL020000025_gene1264	2.876e-104	354.0	COG1804@1|root,COG1804@2|Bacteria,1TP54@1239|Firmicutes,4HABI@91061|Bacilli,1ZM1C@1386|Bacillus	91061|Bacilli	C	CoA-transferase family III	frc	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
PYH3_k127_5285764_8	1499680.CCFE01000023_gene2574	1.246e-75	265.0	COG1804@1|root,COG1804@2|Bacteria,1TP54@1239|Firmicutes,4HABI@91061|Bacilli,1ZM1F@1386|Bacillus	91061|Bacilli	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
PYH3_k127_5350571_4	1449126.JQKL01000003_gene1720	2.212e-22	100.0	COG2050@1|root,COG2050@2|Bacteria,1V824@1239|Firmicutes,24R76@186801|Clostridia	186801|Clostridia	Q	PFAM thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
PYH3_k127_5350571_2	255470.cbdbA344	7.032e-48	181.0	COG0637@1|root,COG1214@1|root,COG0637@2|Bacteria,COG1214@2|Bacteria,2G6ZZ@200795|Chloroflexi,34D2B@301297|Dehalococcoidia	301297|Dehalococcoidia	O	Glycoprotease family	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2,Peptidase_M22
PYH3_k127_5350571_3	552811.Dehly_1127	6.226e-45	168.0	COG0802@1|root,COG0802@2|Bacteria,2G6YV@200795|Chloroflexi,34CZN@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Threonylcarbamoyl adenosine biosynthesis protein TsaE	-	-	-	ko:K06925	-	-	-	-	ko00000,ko03016	-	-	-	TsaE
PYH3_k127_5350571_1	243164.DET0397	1.135e-87	301.0	COG0611@1|root,COG0611@2|Bacteria,2G6SH@200795|Chloroflexi,34CMT@301297|Dehalococcoidia	301297|Dehalococcoidia	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
PYH3_k127_5350571_7	1232410.KI421421_gene3513	1.323e-05	47.0	COG0694@1|root,COG0694@2|Bacteria,1MVQ1@1224|Proteobacteria,42V85@68525|delta/epsilon subdivisions,2WR93@28221|Deltaproteobacteria,43SS6@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	NifU-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Nfu_N,NifU
PYH3_k127_5350571_6	255470.cbdbA1730	1.779e-12	67.0	COG0694@1|root,COG0694@2|Bacteria,2G7BS@200795|Chloroflexi,34DGF@301297|Dehalococcoidia	301297|Dehalococcoidia	O	NifU-like domain	-	-	-	-	-	-	-	-	-	-	-	-	NifU
PYH3_k127_5350571_0	744872.Spica_0950	1.611e-145	469.0	COG0136@1|root,COG0136@2|Bacteria,2J5ZP@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the aspartate-semialdehyde dehydrogenase family	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
PYH3_k127_5350571_5	273116.14325057	2.464e-14	77.0	COG1250@1|root,arCOG00250@2157|Archaea,2XTMV@28890|Euryarchaeota,2429F@183967|Thermoplasmata	183967|Thermoplasmata	I	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
PYH3_k127_536196_18	748727.CLJU_c36510	0.0007114	47.0	2BX5K@1|root,32R8G@2|Bacteria,1V9DD@1239|Firmicutes,24K3D@186801|Clostridia,36M5C@31979|Clostridiaceae	186801|Clostridia	L	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH_3
PYH3_k127_536196_17	1173022.Cri9333_1310	0.000595	50.0	COG2319@1|root,COG2319@2|Bacteria,1G429@1117|Cyanobacteria,1H9VZ@1150|Oscillatoriales	1117|Cyanobacteria	CO	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_536196_13	1206739.BAGJ01000274_gene3902	3.736e-23	102.0	COG0599@1|root,COG0599@2|Bacteria,2IPIY@201174|Actinobacteria,4G4UW@85025|Nocardiaceae	201174|Actinobacteria	S	Carboxymuconolactone decarboxylase family	-	-	-	-	-	-	-	-	-	-	-	-	CMD
PYH3_k127_536196_10	255470.cbdbA511	4.672e-58	206.0	COG1403@1|root,COG1403@2|Bacteria,2G6RY@200795|Chloroflexi,34D86@301297|Dehalococcoidia	301297|Dehalococcoidia	L	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH
PYH3_k127_536196_3	311424.DhcVS_479	1.465e-146	478.0	COG1484@1|root,COG1484@2|Bacteria,2G65F@200795|Chloroflexi,34CQC@301297|Dehalococcoidia	301297|Dehalococcoidia	L	Bacterial dnaA  protein	-	-	-	ko:K02315	-	-	-	-	ko00000,ko03032	-	-	-	IstB_IS21
PYH3_k127_536196_11	1382306.JNIM01000001_gene3959	8.835e-40	158.0	COG3935@1|root,COG3935@2|Bacteria,2G6W5@200795|Chloroflexi	200795|Chloroflexi	L	TIGRFAM primosome, DnaD subunit	-	-	-	-	-	-	-	-	-	-	-	-	DnaB_2
PYH3_k127_536196_1	255470.cbdbA514	3.79e-160	517.0	COG0305@1|root,COG0305@2|Bacteria,2G64D@200795|Chloroflexi,34D09@301297|Dehalococcoidia	301297|Dehalococcoidia	L	Participates in initiation and elongation during chromosome replication	dnaB	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
PYH3_k127_536196_12	255470.cbdbA515	1.808e-36	143.0	COG0359@1|root,COG0359@2|Bacteria,2G6V2@200795|Chloroflexi,34DB3@301297|Dehalococcoidia	301297|Dehalococcoidia	J	binds to the 23S rRNA	rplI	-	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
PYH3_k127_536196_8	697303.Thewi_2202	1.488e-90	307.0	COG0492@1|root,COG0492@2|Bacteria,1TNZS@1239|Firmicutes,2491M@186801|Clostridia,42EKM@68295|Thermoanaerobacterales	186801|Clostridia	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	trxB	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
PYH3_k127_536196_6	552811.Dehly_0638	2.235e-110	366.0	COG0416@1|root,COG0416@2|Bacteria,2G5Z8@200795|Chloroflexi,34CUK@301297|Dehalococcoidia	301297|Dehalococcoidia	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA	plsX	-	2.3.1.15	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_synthesis
PYH3_k127_536196_5	243164.DET0545	7.395e-125	412.0	COG1473@1|root,COG1473@2|Bacteria,2G7D3@200795|Chloroflexi,34D40@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
PYH3_k127_536196_2	311424.DhcVS_545	9.513e-160	510.0	COG2255@1|root,COG2255@2|Bacteria,2G5QQ@200795|Chloroflexi,34D5N@301297|Dehalococcoidia	301297|Dehalococcoidia	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
PYH3_k127_536196_15	591158.SSMG_05622	1.105e-13	78.0	COG0778@1|root,COG0778@2|Bacteria,2I2R7@201174|Actinobacteria	201174|Actinobacteria	C	Cob(II)yrinic acid a,c-diamide reductase	bluB	-	1.13.11.79	ko:K04719	ko00740,ko01100,map00740,map01100	-	R09083	RC00435,RC02413	ko00000,ko00001,ko01000	-	-	-	Nitroreductase
PYH3_k127_536196_7	1064535.MELS_0040	1.89e-96	330.0	COG0577@1|root,COG0577@2|Bacteria,1TPUU@1239|Firmicutes,4H2H6@909932|Negativicutes	909932|Negativicutes	V	Efflux ABC transporter permease protein	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
PYH3_k127_536196_9	926569.ANT_07660	1.067e-77	269.0	COG1136@1|root,COG1136@2|Bacteria,2G69N@200795|Chloroflexi	200795|Chloroflexi	P	Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
PYH3_k127_536196_14	1219084.AP014508_gene647	1.235e-14	87.0	COG0845@1|root,COG0845@2|Bacteria,2GD8D@200918|Thermotogae	200918|Thermotogae	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
PYH3_k127_536196_16	1043493.BBLU01000006_gene2095	3.308e-05	57.0	COG0845@1|root,COG0845@2|Bacteria,2IG0C@201174|Actinobacteria	201174|Actinobacteria	M	HlyD family secretion protein	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3
PYH3_k127_536196_0	552811.Dehly_0674	9.228e-220	694.0	COG0119@1|root,COG0119@2|Bacteria,2G5KT@200795|Chloroflexi,34D2K@301297|Dehalococcoidia	301297|Dehalococcoidia	H	Belongs to the alpha-IPM synthase homocitrate synthase family	-	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
PYH3_k127_536196_4	552811.Dehly_0673	4.541e-125	407.0	COG0473@1|root,COG0473@2|Bacteria,2G63C@200795|Chloroflexi,34CP7@301297|Dehalococcoidia	301297|Dehalococcoidia	CE	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
PYH3_k127_5398638_2	371042.NG99_27075	2.526e-14	75.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,1RNB5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	acyl-CoA transferases carnitine dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
PYH3_k127_5398638_1	243164.DET1251	3.798e-51	187.0	COG0655@1|root,COG0655@2|Bacteria,2G9U1@200795|Chloroflexi,34CYE@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Flavodoxin-like fold	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
PYH3_k127_5398638_0	1280946.HY29_13350	1.455e-150	491.0	COG2272@1|root,COG2272@2|Bacteria,1MVQZ@1224|Proteobacteria,2TTHT@28211|Alphaproteobacteria,43ZKE@69657|Hyphomonadaceae	28211|Alphaproteobacteria	I	Carboxylesterase family	-	-	-	ko:K03929	-	-	-	-	ko00000,ko01000	-	CE10	-	COesterase
PYH3_k127_5440329_5	670487.Ocepr_0868	3.011e-37	147.0	COG1250@1|root,COG1250@2|Bacteria,1WIN8@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	I	PFAM 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
PYH3_k127_5440329_4	324057.Pjdr2_0944	1.817e-38	149.0	COG3981@1|root,COG5646@1|root,COG3981@2|Bacteria,COG5646@2|Bacteria,1V1C4@1239|Firmicutes,4HG6C@91061|Bacilli,26XIE@186822|Paenibacillaceae	91061|Bacilli	K	Acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
PYH3_k127_5440329_2	1429916.X566_15995	9.327e-55	202.0	COG1024@1|root,COG1024@2|Bacteria,1R3U7@1224|Proteobacteria,2TV9G@28211|Alphaproteobacteria,3JU2F@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
PYH3_k127_5440329_7	1056816.JAFQ01000004_gene5590	8.962e-12	70.0	COG3324@1|root,COG3324@2|Bacteria,2IRXF@201174|Actinobacteria,4G1IK@85025|Nocardiaceae	201174|Actinobacteria	S	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	Glyoxalase
PYH3_k127_5440329_6	639282.DEFDS_1187	2.951e-31	136.0	COG0138@1|root,COG0138@2|Bacteria,2GFAQ@200930|Deferribacteres	200930|Deferribacteres	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
PYH3_k127_5440329_1	552811.Dehly_1537	7.835e-69	249.0	COG4346@1|root,COG4346@2|Bacteria	2|Bacteria	O	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	2.4.1.109	ko:K00728	ko00514,ko00515,ko01100,map00514,map00515,map01100	-	R04072,R07620,R11399	RC00005,RC00059,RC00397	ko00000,ko00001,ko01000,ko01003	-	GT39	-	PMT,PMT_2,PMT_4TMC
PYH3_k127_5440329_3	552811.Dehly_1387	8.737e-40	156.0	COG1825@1|root,COG1825@2|Bacteria,2G6YX@200795|Chloroflexi,34CVT@301297|Dehalococcoidia	301297|Dehalococcoidia	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	-	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
PYH3_k127_5440329_0	311424.DhcVS_9	1.86e-115	378.0	COG0115@1|root,COG0115@2|Bacteria,2G5PM@200795|Chloroflexi,34CQR@301297|Dehalococcoidia	301297|Dehalococcoidia	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
PYH3_k127_5485148_1	1101188.KI912155_gene2983	5.688e-50	183.0	COG1804@1|root,COG1804@2|Bacteria,2IB9E@201174|Actinobacteria	201174|Actinobacteria	C	L-carnitine dehydratase bile acid-inducible protein F	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
PYH3_k127_5485148_2	929562.Emtol_2110	5.785e-35	149.0	COG1835@1|root,COG1835@2|Bacteria,4NHPE@976|Bacteroidetes,47JWZ@768503|Cytophagia	976|Bacteroidetes	I	Acyltransferase family	-	-	-	ko:K11941	-	-	-	-	ko00000,ko01000	-	-	-	Acyl_transf_3
PYH3_k127_5485148_0	186497.PF0233	5.729e-60	225.0	COG1042@1|root,arCOG01340@2157|Archaea,2XT9G@28890|Euryarchaeota,242W1@183968|Thermococci	183968|Thermococci	C	CoA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding_2,Succ_CoA_lig
PYH3_k127_5485148_3	1127673.GLIP_2679	0.0001561	44.0	2DT0U@1|root,33I6V@2|Bacteria,1NMHR@1224|Proteobacteria,1SGK7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_5505177_4	192952.MM_0152	0.0006574	46.0	COG0582@1|root,arCOG01241@2157|Archaea	2157|Archaea	L	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules	-	-	-	ko:K03733,ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_integrase
PYH3_k127_5505177_1	311424.DhcVS_531	1.684e-152	488.0	COG0057@1|root,COG0057@2|Bacteria,2G5MG@200795|Chloroflexi,34CRT@301297|Dehalococcoidia	301297|Dehalococcoidia	C	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain	gap	-	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
PYH3_k127_5505177_2	1122609.AUGT01000017_gene824	7.526e-64	231.0	COG0491@1|root,COG0491@2|Bacteria,2GMDD@201174|Actinobacteria,4DP2U@85009|Propionibacteriales	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
PYH3_k127_5505177_0	255470.cbdbA573	7.57e-179	569.0	COG0148@1|root,COG0148@2|Bacteria,2G5VB@200795|Chloroflexi,34CUM@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
PYH3_k127_5505177_3	255470.cbdbA574	9.625e-41	153.0	COG1611@1|root,COG1611@2|Bacteria,2G6YH@200795|Chloroflexi,34CSH@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Possible lysine decarboxylase	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	DNA_processg_A
PYH3_k127_5521505_5	305700.B447_09503	1.054e-15	81.0	2DBU1@1|root,2ZB3C@2|Bacteria,1NB4B@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_5521505_1	1220534.B655_1171	3.798e-106	353.0	COG0451@1|root,arCOG01369@2157|Archaea,2XUDM@28890|Euryarchaeota	28890|Euryarchaeota	M	NAD-dependent epimerase dehydratase	-	-	1.1.1.219	ko:K00091	-	-	-	-	ko00000,ko01000	-	-	-	Epimerase
PYH3_k127_5521505_3	1009370.ALO_16277	1.106e-56	201.0	COG2193@1|root,COG2193@2|Bacteria	2|Bacteria	P	ferroxidase activity	bfr	GO:0003674,GO:0003824,GO:0004322,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006873,GO:0006875,GO:0006879,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0016020,GO:0016491,GO:0016722,GO:0016724,GO:0019725,GO:0030003,GO:0033212,GO:0033214,GO:0042221,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0055114,GO:0065007,GO:0065008,GO:0071944,GO:0098771	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
PYH3_k127_5521505_2	243164.DET1036	1.988e-76	267.0	COG0265@1|root,COG0265@2|Bacteria,2GAJH@200795|Chloroflexi,34CVE@301297|Dehalococcoidia	301297|Dehalococcoidia	M	Trypsin-like serine protease	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin_2
PYH3_k127_5521505_4	266779.Meso_1466	8.087e-18	87.0	COG4274@1|root,COG4274@2|Bacteria,1N29P@1224|Proteobacteria,2UD2U@28211|Alphaproteobacteria,43QUM@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	GYD domain	-	-	-	-	-	-	-	-	-	-	-	-	GYD
PYH3_k127_5521505_6	1265505.ATUG01000002_gene2036	2.329e-07	56.0	2DI0Z@1|root,32UA6@2|Bacteria,1N1UY@1224|Proteobacteria,42UQX@68525|delta/epsilon subdivisions,2WR5W@28221|Deltaproteobacteria,2MKRN@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_5521505_0	1499967.BAYZ01000019_gene6322	1.005e-137	446.0	COG0501@1|root,COG0501@2|Bacteria,2NP9X@2323|unclassified Bacteria	2|Bacteria	O	CAAX prenyl protease N-terminal, five membrane helices	htpX_2	-	3.4.24.84	ko:K06013	ko00900,ko01130,map00900,map01130	-	R09845	RC00141	ko00000,ko00001,ko01000,ko01002,ko04147	-	-	-	Peptidase_M48,Peptidase_M48_N
PYH3_k127_5616582_7	879212.DespoDRAFT_03702	4.316e-30	121.0	COG0464@1|root,COG0464@2|Bacteria,1NF48@1224|Proteobacteria,43BJ4@68525|delta/epsilon subdivisions,2WMCV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA
PYH3_k127_5616582_6	749414.SBI_09002	1.631e-31	134.0	28RC2@1|root,2ZDRH@2|Bacteria,2GNI9@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF4255)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4255
PYH3_k127_5616582_0	1382306.JNIM01000001_gene3331	1.098e-186	598.0	COG3497@1|root,COG3497@2|Bacteria,2G6KW@200795|Chloroflexi	200795|Chloroflexi	S	Tail sheath protein	-	-	-	ko:K06907	-	-	-	-	ko00000	-	-	-	Phage_sheath_1,Phage_sheath_1C
PYH3_k127_5616582_3	926560.KE387023_gene3051	9.647e-45	166.0	2DC11@1|root,2ZCAY@2|Bacteria,1WMSV@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	T4-like virus tail tube protein gp19	-	-	-	-	-	-	-	-	-	-	-	-	Phage_T4_gp19
PYH3_k127_5616582_4	1463926.JOCA01000031_gene4885	2.596e-42	158.0	arCOG11412@1|root,31S84@2|Bacteria,2IHRW@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_5616582_8	497965.Cyan7822_4454	8.022e-12	70.0	arCOG11411@1|root,33A8Q@2|Bacteria,1GFT1@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_5616582_5	357808.RoseRS_1660	4.332e-37	145.0	2DMQT@1|root,32T2H@2|Bacteria,2G8MM@200795|Chloroflexi	200795|Chloroflexi	S	T4-like virus tail tube protein gp19	-	-	-	-	-	-	-	-	-	-	-	-	Phage_T4_gp19
PYH3_k127_5616582_2	383372.Rcas_2818	3.126e-61	217.0	COG1652@1|root,COG1652@2|Bacteria,2G7PE@200795|Chloroflexi	200795|Chloroflexi	S	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	LysM
PYH3_k127_5616582_1	383372.Rcas_2817	6.952e-128	430.0	COG3501@1|root,COG3501@2|Bacteria,2G7FE@200795|Chloroflexi	200795|Chloroflexi	S	Phage late control gene D protein (GPD)	-	-	-	-	-	-	-	-	-	-	-	-	Phage_GPD
PYH3_k127_5616582_9	1120965.AUBV01000004_gene885	1.488e-08	56.0	COG4104@1|root,COG4104@2|Bacteria	2|Bacteria	T	PAAR repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	PAAR_motif
PYH3_k127_5617029_0	311424.DhcVS_1002	7.604e-177	569.0	COG0249@1|root,COG0249@2|Bacteria,2G5IU@200795|Chloroflexi,34CWG@301297|Dehalococcoidia	301297|Dehalococcoidia	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
PYH3_k127_5617029_3	1380355.JNIJ01000026_gene1330	1.989e-124	407.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TR0N@28211|Alphaproteobacteria,3JUIB@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
PYH3_k127_5617029_4	1380387.JADM01000003_gene2658	3.442e-121	396.0	COG1173@1|root,COG1173@2|Bacteria,1MVHY@1224|Proteobacteria,1RR5Y@1236|Gammaproteobacteria,1XNJ2@135619|Oceanospirillales	135619|Oceanospirillales	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
PYH3_k127_5617029_1	1297865.APJD01000009_gene2851	9.741e-160	523.0	COG0747@1|root,COG0747@2|Bacteria,1PFW6@1224|Proteobacteria,2U1GT@28211|Alphaproteobacteria,3JUHW@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Peptide ABC transporter substrate-binding protein	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
PYH3_k127_5617029_2	1380355.JNIJ01000026_gene1330	1.715e-124	406.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TR0N@28211|Alphaproteobacteria,3JUIB@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
PYH3_k127_5617029_6	930169.B5T_03305	3.878e-106	353.0	COG1173@1|root,COG1173@2|Bacteria,1MU26@1224|Proteobacteria,1RND6@1236|Gammaproteobacteria,1XH9S@135619|Oceanospirillales	135619|Oceanospirillales	EP	N-terminal TM domain of oligopeptide transport permease C	-	-	-	ko:K02034,ko:K15582	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1,OppC_N
PYH3_k127_5617029_5	196490.AUEZ01000005_gene3558	4.821e-111	383.0	COG0747@1|root,COG0747@2|Bacteria,1PFW6@1224|Proteobacteria,2U1GT@28211|Alphaproteobacteria,3JUHW@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Peptide ABC transporter substrate-binding protein	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
PYH3_k127_5617029_7	1379698.RBG1_1C00001G0050	2.998e-93	325.0	COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria	2|Bacteria	C	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_20,Pyr_redox_2,Pyr_redox_3
PYH3_k127_5617029_8	646529.Desaci_1059	1.978e-56	205.0	COG1149@1|root,COG1149@2|Bacteria,1VDSQ@1239|Firmicutes,24NTS@186801|Clostridia,265ZR@186807|Peptococcaceae	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
PYH3_k127_5629104_5	368407.Memar_2454	7.243e-21	93.0	COG4802@1|root,arCOG01100@2157|Archaea,2XXWK@28890|Euryarchaeota	28890|Euryarchaeota	C	Ferredoxin thioredoxin reductase catalytic beta chain	-	-	-	-	-	-	-	-	-	-	-	-	FeThRed_B
PYH3_k127_5629104_4	316058.RPB_0227	2.375e-28	125.0	28HWH@1|root,2Z82E@2|Bacteria,1MUF7@1224|Proteobacteria,2TV8Z@28211|Alphaproteobacteria,3JV6A@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_5629104_1	1313172.YM304_30720	3.914e-50	190.0	COG1024@1|root,COG1024@2|Bacteria,2GN3P@201174|Actinobacteria	201174|Actinobacteria	I	Enoyl-CoA hydratase	-	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
PYH3_k127_5629104_0	96561.Dole_0556	2.609e-58	214.0	COG0778@1|root,COG1143@1|root,COG0778@2|Bacteria,COG1143@2|Bacteria,1PE5U@1224|Proteobacteria,42VB3@68525|delta/epsilon subdivisions,2WS8C@28221|Deltaproteobacteria,2MN7P@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Nitroreductase
PYH3_k127_5629104_3	390874.Tpet_1016	9.643e-29	120.0	COG2153@1|root,COG2153@2|Bacteria,2GE9G@200918|Thermotogae	200918|Thermotogae	S	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10
PYH3_k127_5629104_2	1123258.AQXZ01000016_gene2364	1.082e-36	149.0	COG1024@1|root,COG1024@2|Bacteria,2IC54@201174|Actinobacteria,4G2U3@85025|Nocardiaceae	201174|Actinobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
PYH3_k127_5629104_6	936550.HMPREF1492_1423	6.06e-06	50.0	COG0034@1|root,COG0034@2|Bacteria,2GK6I@201174|Actinobacteria,4CV2M@84998|Coriobacteriia	84998|Coriobacteriia	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_7,Pribosyltran
PYH3_k127_5638669_7	443143.GM18_1335	9.552e-74	251.0	COG2086@1|root,COG2086@2|Bacteria,1MVH6@1224|Proteobacteria,42RMH@68525|delta/epsilon subdivisions,2WNKC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM Electron transfer flavoprotein alpha beta-subunit	-	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
PYH3_k127_5638669_1	269799.Gmet_0684	1.133e-189	602.0	COG1145@1|root,COG2025@1|root,COG1145@2|Bacteria,COG2025@2|Bacteria,1MUFI@1224|Proteobacteria,42M3T@68525|delta/epsilon subdivisions,2WIV8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	electron transfer flavoprotein, alpha subunit	-	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	iAF987.Gmet_2066	ETF,ETF_alpha,Fer4
PYH3_k127_5638669_2	269799.Gmet_0685	1.113e-183	596.0	COG0247@1|root,COG0247@2|Bacteria,1MUMH@1224|Proteobacteria,42MIV@68525|delta/epsilon subdivisions,2WJ5X@28221|Deltaproteobacteria,43T69@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
PYH3_k127_5638669_9	1380355.JNIJ01000020_gene3787	3.698e-64	229.0	COG0596@1|root,COG0596@2|Bacteria,1Q4C8@1224|Proteobacteria,2TTW5@28211|Alphaproteobacteria,3JTEC@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Serine aminopeptidase, S33	MA20_23630	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
PYH3_k127_5638669_3	1121004.ATVC01000003_gene490	1.486e-91	314.0	COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,2VJ1W@28216|Betaproteobacteria,2KQ77@206351|Neisseriales	206351|Neisseriales	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
PYH3_k127_5638669_8	552811.Dehly_0088	4.955e-70	248.0	COG1230@1|root,COG1230@2|Bacteria,2G6FI@200795|Chloroflexi,34D5R@301297|Dehalococcoidia	301297|Dehalococcoidia	P	Cation efflux family	-	-	-	ko:K16264	-	-	-	-	ko00000,ko02000	2.A.4.1	-	-	Cation_efflux
PYH3_k127_5638669_12	398512.JQKC01000002_gene1877	2.106e-52	190.0	COG0634@1|root,COG0634@2|Bacteria,1V1C9@1239|Firmicutes,24FR4@186801|Clostridia,3WIX7@541000|Ruminococcaceae	186801|Clostridia	F	Belongs to the purine pyrimidine phosphoribosyltransferase family	hpt	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
PYH3_k127_5638669_0	243164.DET0791	1.314e-217	689.0	COG1001@1|root,COG1001@2|Bacteria,2G64P@200795|Chloroflexi,34D5C@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family	ade	-	3.5.4.2	ko:K01486	ko00230,ko01100,map00230,map01100	-	R01244	RC00477	ko00000,ko00001,ko01000	-	-	-	Adenine_deam_C,Amidohydro_1
PYH3_k127_5638669_4	552811.Dehly_0204	5.733e-91	309.0	COG3872@1|root,COG3872@2|Bacteria,2G5XQ@200795|Chloroflexi,34D3S@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Protein of unknown function (DUF1385)	-	-	-	ko:K09153	-	-	-	-	ko00000	-	-	-	DUF1385
PYH3_k127_5638669_19	697281.Mahau_0239	1.161e-28	115.0	COG0254@1|root,COG0254@2|Bacteria,1VEGU@1239|Firmicutes,24QNZ@186801|Clostridia,42H2T@68295|Thermoanaerobacterales	186801|Clostridia	J	Binds the 23S rRNA	rpmE	-	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
PYH3_k127_5638669_17	1382306.JNIM01000001_gene3847	7.462e-29	117.0	COG0211@1|root,COG0211@2|Bacteria,2G709@200795|Chloroflexi	200795|Chloroflexi	J	Belongs to the bacterial ribosomal protein bL27 family	rpmA	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
PYH3_k127_5638669_18	311424.DhcVS_1107	7.593e-29	119.0	COG0261@1|root,COG0261@2|Bacteria,2G72T@200795|Chloroflexi,34DBA@301297|Dehalococcoidia	301297|Dehalococcoidia	J	This protein binds to 23S rRNA in the presence of protein L20	rplU	-	-	ko:K02888	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21p
PYH3_k127_5638669_13	128390.XP_009460243.1	4.224e-46	173.0	COG0237@1|root,COG1019@1|root,COG1028@1|root,KOG1319@1|root,KOG1205@2759|Eukaryota,KOG1319@2759|Eukaryota,KOG3220@2759|Eukaryota,KOG3351@2759|Eukaryota,38H33@33154|Opisthokonta,3BCJW@33208|Metazoa,3CSPG@33213|Bilateria,483JW@7711|Chordata,4918F@7742|Vertebrata,4GHJ6@8782|Aves	33208|Metazoa	H	Bifunctional coenzyme A synthase	COASY	GO:0000003,GO:0001667,GO:0002009,GO:0002064,GO:0002065,GO:0002066,GO:0002165,GO:0003006,GO:0003674,GO:0003824,GO:0004140,GO:0004595,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005740,GO:0005741,GO:0005759,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006928,GO:0007275,GO:0007276,GO:0007281,GO:0007292,GO:0007297,GO:0007300,GO:0007303,GO:0007444,GO:0007472,GO:0007476,GO:0007552,GO:0007560,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009653,GO:0009791,GO:0009886,GO:0009887,GO:0009888,GO:0009987,GO:0010631,GO:0015936,GO:0015937,GO:0016020,GO:0016301,GO:0016310,GO:0016477,GO:0016482,GO:0016740,GO:0016772,GO:0016773,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019867,GO:0019953,GO:0022412,GO:0022414,GO:0030154,GO:0030707,GO:0030855,GO:0031090,GO:0031966,GO:0031967,GO:0031968,GO:0031974,GO:0031975,GO:0031981,GO:0032501,GO:0032502,GO:0032504,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0035107,GO:0035114,GO:0035120,GO:0035220,GO:0035239,GO:0035295,GO:0040011,GO:0042592,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0044703,GO:0046390,GO:0046483,GO:0046907,GO:0048468,GO:0048477,GO:0048513,GO:0048563,GO:0048569,GO:0048609,GO:0048707,GO:0048729,GO:0048731,GO:0048736,GO:0048737,GO:0048856,GO:0048869,GO:0048870,GO:0048878,GO:0051179,GO:0051186,GO:0051188,GO:0051234,GO:0051641,GO:0051649,GO:0051674,GO:0051704,GO:0055086,GO:0055088,GO:0055090,GO:0060429,GO:0060562,GO:0065007,GO:0065008,GO:0070013,GO:0070328,GO:0070566,GO:0071704,GO:0072521,GO:0072522,GO:0090130,GO:0090132,GO:0090407,GO:0098588,GO:0098805,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.1.24,2.7.7.3	ko:K02318	ko00770,ko01100,map00770,map01100	M00120	R00130,R03035	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like,CoaE
PYH3_k127_5638669_14	1121430.JMLG01000002_gene1156	4.212e-41	159.0	COG1544@1|root,COG1544@2|Bacteria,1V1D5@1239|Firmicutes,24HDH@186801|Clostridia,261QJ@186807|Peptococcaceae	186801|Clostridia	J	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase	hpf	-	-	ko:K05808	-	-	-	-	ko00000,ko03009	-	-	-	Ribosom_S30AE_C,Ribosomal_S30AE
PYH3_k127_5638669_11	243164.DET1458	4.942e-60	215.0	COG1040@1|root,COG1040@2|Bacteria,2G6WB@200795|Chloroflexi,34CXG@301297|Dehalococcoidia	301297|Dehalococcoidia	S	competence protein	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_5638669_16	552811.Dehly_1716	2.536e-30	121.0	2EQ8R@1|root,33HV0@2|Bacteria,2G91J@200795|Chloroflexi,34DHP@301297|Dehalococcoidia	301297|Dehalococcoidia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_5638669_15	552811.Dehly_1587	7.624e-41	158.0	COG1514@1|root,COG1514@2|Bacteria,2G76S@200795|Chloroflexi,34D41@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	-	-	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
PYH3_k127_5638669_6	311424.DhcVS_1233	4.941e-79	275.0	COG2159@1|root,COG2159@2|Bacteria,2G6CW@200795|Chloroflexi,34CYX@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
PYH3_k127_5638669_5	255470.cbdbA1120	1.699e-87	292.0	COG0302@1|root,COG0302@2|Bacteria,2G6VZ@200795|Chloroflexi,34D51@301297|Dehalococcoidia	301297|Dehalococcoidia	F	GTP cyclohydrolase I activity	folE	-	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydroI
PYH3_k127_5638669_20	1499680.CCFE01000023_gene2571	6.732e-10	61.0	29T5J@1|root,30EC9@2|Bacteria,1UCDP@1239|Firmicutes,4INW2@91061|Bacilli,1ZP11@1386|Bacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_5638669_21	1243664.CAVL020000025_gene1262	1.572e-08	58.0	29T5J@1|root,30EC9@2|Bacteria,1UCDP@1239|Firmicutes,4INW2@91061|Bacilli,1ZP11@1386|Bacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_5638669_10	255470.cbdbA1122	1.917e-63	220.0	COG0498@1|root,COG0498@2|Bacteria,2G66Y@200795|Chloroflexi,34D2S@301297|Dehalococcoidia	301297|Dehalococcoidia	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	thrC	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
PYH3_k127_5672288_2	1123504.JQKD01000012_gene1258	3.749e-47	179.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VJ3K@28216|Betaproteobacteria,4AG7T@80864|Comamonadaceae	28216|Betaproteobacteria	C	CoA-transferase family III	-	-	2.8.3.15	ko:K07544	ko00623,ko01100,ko01120,ko01220,map00623,map01100,map01120,map01220	M00418	R05588	RC00014,RC00137	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_transf_3
PYH3_k127_5672288_1	243164.DET1404	5.01e-52	188.0	COG3359@1|root,COG3359@2|Bacteria,2G6TK@200795|Chloroflexi,34CWC@301297|Dehalococcoidia	301297|Dehalococcoidia	L	RNase_H superfamily	-	-	-	ko:K07502	-	-	-	-	ko00000	-	-	-	RNase_H_2
PYH3_k127_5672288_0	555779.Dthio_PD3220	4.936e-120	394.0	COG0685@1|root,COG0685@2|Bacteria,1MXTZ@1224|Proteobacteria,42NTS@68525|delta/epsilon subdivisions,2WK04@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	PFAM Methylenetetrahydrofolate reductase	metF-1	-	1.5.1.20,2.1.1.10	ko:K00297,ko:K00547	ko00270,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01523,map00270,map00670,map00720,map01100,map01110,map01120,map01200,map01523	M00377	R00650,R01224,R07168	RC00003,RC00035,RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
PYH3_k127_5672288_3	706587.Desti_0168	1.256e-14	75.0	COG4656@1|root,COG4656@2|Bacteria,1MWAX@1224|Proteobacteria,42NJM@68525|delta/epsilon subdivisions,2WKM6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM Methylene-tetrahydrofolate reductase C terminal	-	-	-	-	-	-	-	-	-	-	-	-	MTHFR_C
PYH3_k127_5698284_0	255470.cbdbA928	9.101e-198	629.0	COG0514@1|root,COG1205@1|root,COG0514@2|Bacteria,COG1205@2|Bacteria,2G605@200795|Chloroflexi,34CMG@301297|Dehalococcoidia	301297|Dehalococcoidia	L	Domain of unknown function (DUF1998)	-	-	-	ko:K06877	-	-	-	-	ko00000	-	-	-	DEAD,DUF1998,Helicase_C
PYH3_k127_5698284_3	525904.Tter_1743	3.646e-20	93.0	COG1550@1|root,COG1550@2|Bacteria	2|Bacteria	H	Protein conserved in bacteria	ylxP	-	-	ko:K09764	-	-	-	-	ko00000	-	-	-	DUF503
PYH3_k127_5698284_4	864702.OsccyDRAFT_1898	5.606e-19	88.0	COG2944@1|root,COG2944@2|Bacteria,1G6V7@1117|Cyanobacteria,1HBR9@1150|Oscillatoriales	1117|Cyanobacteria	K	Helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
PYH3_k127_5698284_2	935840.JAEQ01000009_gene1321	1.2e-80	279.0	COG2159@1|root,COG2159@2|Bacteria,1MUUR@1224|Proteobacteria,2TSQB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	metal-dependent hydrolase of the TIM-barrel fold	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
PYH3_k127_5698284_1	255470.cbdbA861	5.611e-166	528.0	COG2309@1|root,COG2309@2|Bacteria,2G5TH@200795|Chloroflexi,34CT4@301297|Dehalococcoidia	301297|Dehalococcoidia	E	Thermophilic metalloprotease (M29)	-	-	-	ko:K19689	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M29
PYH3_k127_5698284_6	1038859.AXAU01000002_gene209	4.511e-15	78.0	2EGPU@1|root,33AFZ@2|Bacteria,1NH69@1224|Proteobacteria,2UJXH@28211|Alphaproteobacteria,3K1GM@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_5698284_5	156889.Mmc1_0764	1.371e-15	77.0	2E3ZS@1|root,32YWP@2|Bacteria,1NAZV@1224|Proteobacteria,2UGW3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_5894178_1	1429916.X566_03930	2.64e-75	276.0	COG0747@1|root,COG0747@2|Bacteria,1PFW6@1224|Proteobacteria,2U1GT@28211|Alphaproteobacteria,3JUHW@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Peptide ABC transporter substrate-binding protein	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
PYH3_k127_5894178_0	641491.DND132_0960	5.892e-108	374.0	COG3379@1|root,COG3379@2|Bacteria,1NBJ6@1224|Proteobacteria,42PUB@68525|delta/epsilon subdivisions,2WMH5@28221|Deltaproteobacteria,2M93I@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM type I phosphodiesterase nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
PYH3_k127_5894178_2	439235.Dalk_2989	1.72e-22	104.0	COG3119@1|root,COG3119@2|Bacteria,1PFYE@1224|Proteobacteria,43A2J@68525|delta/epsilon subdivisions,2WQC7@28221|Deltaproteobacteria,2MNWS@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
PYH3_k127_5927848_1	255470.cbdbA130	1.311e-117	387.0	COG1740@1|root,COG1740@2|Bacteria,2G6Y3@200795|Chloroflexi,34D71@301297|Dehalococcoidia	301297|Dehalococcoidia	C	NiFe/NiFeSe hydrogenase small subunit C-terminal	hupS	-	1.12.99.6	ko:K06282	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFe_hyd_SSU_C,Oxidored_q6
PYH3_k127_5927848_2	1034347.CAHJ01000032_gene4096	3.879e-61	221.0	COG0437@1|root,COG0437@2|Bacteria,1VVN3@1239|Firmicutes,4IN1W@91061|Bacilli,1ZMKI@1386|Bacillus	91061|Bacilli	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_11
PYH3_k127_5927848_0	255470.cbdbA129	1.414e-219	689.0	COG0374@1|root,COG0374@2|Bacteria,2G6SF@200795|Chloroflexi,34CJW@301297|Dehalococcoidia	301297|Dehalococcoidia	C	hydrogenase large subunit	hupL	-	1.12.99.6	ko:K06281	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
PYH3_k127_5987994_8	264198.Reut_C6314	3.088e-08	60.0	COG2368@1|root,COG2368@2|Bacteria,1PEQG@1224|Proteobacteria,2VKCH@28216|Betaproteobacteria,1K3N6@119060|Burkholderiaceae	28216|Betaproteobacteria	Q	4-hydroxyphenylacetate	-	-	1.14.14.9,4.2.1.120,5.3.3.3	ko:K00483,ko:K14534	ko00350,ko00650,ko00720,ko01100,ko01120,ko01200,ko01220,map00350,map00650,map00720,map01100,map01120,map01200,map01220	M00374,M00375	R02698,R03031,R03299,R10782	RC00046,RC01857,RC03277	ko00000,ko00001,ko00002,ko01000	-	-	-	HpaB,HpaB_N
PYH3_k127_5987994_7	1220534.B655_1032	1.683e-11	72.0	COG1309@1|root,arCOG02643@2157|Archaea	2157|Archaea	K	PFAM regulatory protein TetR	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
PYH3_k127_5987994_6	1120950.KB892770_gene1386	5.751e-26	117.0	COG0491@1|root,COG0491@2|Bacteria,2HFVZ@201174|Actinobacteria,4DVND@85009|Propionibacteriales	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	ko:K05555	ko01057,ko01130,map01057,map01130	M00778	R09305	-	ko00000,ko00001,ko00002,ko01000,ko01008	-	-	-	FAA_hydrolase,Lactamase_B
PYH3_k127_5987994_3	1122604.JONR01000009_gene2390	5.585e-56	208.0	COG3509@1|root,COG3509@2|Bacteria,1N6M6@1224|Proteobacteria,1S6C7@1236|Gammaproteobacteria,1X7FG@135614|Xanthomonadales	135614|Xanthomonadales	Q	Esterase PHB depolymerase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase_phd
PYH3_k127_5987994_0	1449126.JQKL01000002_gene1598	6.392e-206	650.0	COG2368@1|root,COG2368@2|Bacteria,1TQ70@1239|Firmicutes,248RP@186801|Clostridia,267KG@186813|unclassified Clostridiales	186801|Clostridia	Q	4-hydroxyphenylacetate 3-hydroxylase C terminal	-	-	1.14.14.9	ko:K00483	ko00350,ko01120,ko01220,map00350,map01120,map01220	-	R02698,R03299	RC00046	ko00000,ko00001,ko01000	-	-	-	HpaB,HpaB_N
PYH3_k127_5987994_2	113395.AXAI01000030_gene2674	7.148e-68	241.0	COG0596@1|root,COG0596@2|Bacteria,1MUSF@1224|Proteobacteria,2TSK5@28211|Alphaproteobacteria,3JWU3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Alpha/beta hydrolase family	-	-	-	ko:K22318	-	-	-	-	ko00000	-	-	-	Abhydrolase_1
PYH3_k127_5987994_1	485913.Krac_4166	1.198e-75	270.0	COG0596@1|root,COG0596@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on ester bonds	dhmA	-	3.8.1.5	ko:K01563	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05284,R05367,R05368,R05369,R05370,R07669,R07670	RC01317,RC01340,RC01341,RC02013	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
PYH3_k127_5987994_5	653733.Selin_1519	1.898e-44	167.0	COG1636@1|root,COG1636@2|Bacteria	2|Bacteria	C	queuosine biosynthetic process	queH	-	1.17.99.6,3.1.26.4	ko:K03470,ko:K09765	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03032	-	-	-	DUF208
PYH3_k127_5987994_4	255470.cbdbA732	1.393e-52	193.0	COG4359@1|root,COG4359@2|Bacteria,2GAJK@200795|Chloroflexi,34CJE@301297|Dehalococcoidia	301297|Dehalococcoidia	E	haloacid dehalogenase-like hydrolase	-	-	3.1.3.87	ko:K08966	ko00270,ko01100,map00270,map01100	M00034	R07394	RC02074	ko00000,ko00001,ko00002,ko01000	-	-	-	HAD
PYH3_k127_5987994_9	243164.DET0351	5.019e-06	51.0	COG3103@1|root,COG4991@2|Bacteria,2G9F6@200795|Chloroflexi,34D2H@301297|Dehalococcoidia	301297|Dehalococcoidia	T	sh3 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_5997237_4	243164.DET1252	1.051e-11	67.0	2BPH6@1|root,32I9K@2|Bacteria,2G9VZ@200795|Chloroflexi,34DH6@301297|Dehalococcoidia	301297|Dehalococcoidia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_5997237_5	1121920.AUAU01000014_gene2802	4.675e-09	66.0	2ENGF@1|root,33G3Y@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_5997237_3	243164.DET1501	9.522e-30	123.0	COG0716@1|root,COG0716@2|Bacteria,2GAZ4@200795|Chloroflexi,34DME@301297|Dehalococcoidia	301297|Dehalococcoidia	C	Flavodoxin	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_5997237_1	1128421.JAGA01000002_gene1889	1.722e-101	338.0	COG2084@1|root,COG2084@2|Bacteria	2|Bacteria	I	phosphogluconate dehydrogenase (decarboxylating) activity	glxR	-	1.1.1.31,1.1.1.60	ko:K00020,ko:K00042	ko00280,ko00630,ko01100,map00280,map00630,map01100	-	R01745,R01747,R05066	RC00099	ko00000,ko00001,ko01000	-	-	iJN678.mmsB	NAD_binding_11,NAD_binding_2
PYH3_k127_5997237_2	292459.STH638	1.261e-52	192.0	COG0778@1|root,COG0778@2|Bacteria,1V2D6@1239|Firmicutes,25B91@186801|Clostridia	186801|Clostridia	C	PFAM Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
PYH3_k127_5997237_0	552811.Dehly_0707	1.115e-163	530.0	COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,2G6SR@200795|Chloroflexi,34CV6@301297|Dehalococcoidia	200795|Chloroflexi	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	1.4.1.13,1.4.1.14,1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K00266,ko:K03388	ko00250,ko00680,ko00910,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00250,map00680,map00910,map01100,map01110,map01120,map01130,map01200,map01230	M00356,M00357,M00563,M00567	R00093,R00114,R00248,R04540,R11928,R11931,R11943,R11944	RC00006,RC00010,RC00011,RC02799	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_20,Pyr_redox_2
PYH3_k127_6020828_1	477974.Daud_0678	1.917e-65	231.0	COG0778@1|root,COG0778@2|Bacteria,1UY72@1239|Firmicutes,248YJ@186801|Clostridia,266KR@186807|Peptococcaceae	186801|Clostridia	C	PFAM Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
PYH3_k127_6020828_0	555088.DealDRAFT_1879	7.767e-220	707.0	COG1067@1|root,COG1067@2|Bacteria,1TQT5@1239|Firmicutes,248NE@186801|Clostridia,42JHB@68298|Syntrophomonadaceae	186801|Clostridia	O	Endopeptidase La	-	-	-	-	-	-	-	-	-	-	-	-	AAA_32,Lon_C
PYH3_k127_6020828_2	552811.Dehly_1130	1.644e-08	55.0	COG1989@1|root,COG1989@2|Bacteria,2G797@200795|Chloroflexi,34D0V@301297|Dehalococcoidia	301297|Dehalococcoidia	NOU	Type IV leader peptidase family	-	-	3.4.23.43	ko:K02654	-	M00331	-	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2	-	-	DiS_P_DiS,Peptidase_A24
PYH3_k127_6151601_0	667014.Thein_1357	8.42e-205	676.0	COG1924@1|root,COG3580@1|root,COG3581@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,COG3581@2|Bacteria,2GGV4@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	I	CoA enzyme activase uncharacterised domain (DUF2229)	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,DUF2229
PYH3_k127_6151601_1	519442.Huta_1335	3.854e-68	241.0	COG0667@1|root,arCOG06306@2157|Archaea,2XSXS@28890|Euryarchaeota,23TY2@183963|Halobacteria	183963|Halobacteria	C	oxidoreductases (related to aryl-alcohol dehydrogenases)	mocA	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
PYH3_k127_6160022_2	1101188.KI912155_gene2984	4.728e-93	316.0	COG1804@1|root,COG1804@2|Bacteria,2GMIW@201174|Actinobacteria	201174|Actinobacteria	C	L-carnitine dehydratase bile acid-inducible protein F	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
PYH3_k127_6160022_0	255470.cbdbA815	1.586e-236	742.0	COG0129@1|root,COG0129@2|Bacteria,2G5QW@200795|Chloroflexi,34CXK@301297|Dehalococcoidia	301297|Dehalococcoidia	EG	dihydroxy-acid dehydratase activity	ilvD	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
PYH3_k127_6160022_1	243164.DET0833	4.186e-194	612.0	COG0028@1|root,COG0028@2|Bacteria,2G5Q7@200795|Chloroflexi,34CWN@301297|Dehalococcoidia	301297|Dehalococcoidia	H	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain	ilvB	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
PYH3_k127_6216581_12	1536772.R70723_05450	2.26e-35	141.0	COG1595@1|root,COG1595@2|Bacteria,1V4E2@1239|Firmicutes,4HQHG@91061|Bacilli,26X5G@186822|Paenibacillaceae	91061|Bacilli	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
PYH3_k127_6216581_9	311424.DhcVS_181	1.521e-72	253.0	COG0345@1|root,COG0345@2|Bacteria,2G5QD@200795|Chloroflexi,34D36@301297|Dehalococcoidia	301297|Dehalococcoidia	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	-	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_oxidored,P5CR_dimer
PYH3_k127_6216581_0	552811.Dehly_1143	0.0	1241.0	COG0495@1|root,COG0495@2|Bacteria,2G5MX@200795|Chloroflexi,34CK0@301297|Dehalococcoidia	301297|Dehalococcoidia	J	leucyl-tRNA aminoacylation	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1
PYH3_k127_6216581_15	909663.KI867150_gene1149	7.939e-15	81.0	COG0664@1|root,COG0664@2|Bacteria,1NAYS@1224|Proteobacteria,42W1E@68525|delta/epsilon subdivisions,2WS96@28221|Deltaproteobacteria,2MS9T@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	PFAM Cyclic nucleotide-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
PYH3_k127_6216581_1	555088.DealDRAFT_1878	8.158e-308	956.0	COG0365@1|root,COG0365@2|Bacteria,1TQTI@1239|Firmicutes	1239|Firmicutes	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
PYH3_k127_6216581_2	552811.Dehly_1331	1.44e-202	639.0	COG0119@1|root,COG0119@2|Bacteria,2G5V9@200795|Chloroflexi,34CKK@301297|Dehalococcoidia	301297|Dehalococcoidia	E	HMGL-like	-	-	2.3.3.14	ko:K02594	ko00620,map00620	-	R00271	RC00004,RC00067,RC02754	ko00000,ko00001,ko01000	-	-	-	HMGL-like
PYH3_k127_6216581_4	243164.DET0450	1.323e-160	512.0	COG0473@1|root,COG0473@2|Bacteria,2G68P@200795|Chloroflexi,34D3A@301297|Dehalococcoidia	301297|Dehalococcoidia	C	Isocitrate/isopropylmalate dehydrogenase	-	-	1.1.1.41	ko:K00030	ko00020,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010	R00709	RC00114	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
PYH3_k127_6216581_8	255470.cbdbA407	7.654e-74	252.0	COG0066@1|root,COG0066@2|Bacteria,2G6PB@200795|Chloroflexi,34D8T@301297|Dehalococcoidia	301297|Dehalococcoidia	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	-	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
PYH3_k127_6216581_3	243164.DET0448	3.526e-186	589.0	COG0065@1|root,COG0065@2|Bacteria,2G5IZ@200795|Chloroflexi,34D6T@301297|Dehalococcoidia	301297|Dehalococcoidia	H	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	-	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
PYH3_k127_6216581_10	255470.cbdbA241	1.164e-68	249.0	COG0642@1|root,COG2202@1|root,COG2202@2|Bacteria,COG2205@2|Bacteria,2GAZ9@200795|Chloroflexi,34DMS@301297|Dehalococcoidia	301297|Dehalococcoidia	T	Protein of unknown function (DUF1638)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1638,HATPase_c,HisKA
PYH3_k127_6216581_7	552811.Dehly_0999	1.708e-78	269.0	COG0745@1|root,COG0745@2|Bacteria,2G5ND@200795|Chloroflexi,34DEA@301297|Dehalococcoidia	301297|Dehalococcoidia	K	Transcriptional regulatory protein, C terminal	-	-	-	ko:K07667	ko02020,ko02024,map02020,map02024	M00454	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
PYH3_k127_6216581_14	886293.Sinac_4756	1.811e-15	87.0	COG0515@1|root,COG0515@2|Bacteria,2IYF2@203682|Planctomycetes	203682|Planctomycetes	KLT	COG0515 Serine threonine protein	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	HDOD,Pkinase
PYH3_k127_6216581_11	498761.HM1_1368	1.057e-41	156.0	COG0222@1|root,COG0222@2|Bacteria,1V6EI@1239|Firmicutes,24JAC@186801|Clostridia	186801|Clostridia	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation	rplL	-	-	ko:K02935	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L12,Ribosomal_L12_N
PYH3_k127_6216581_13	255470.cbdbA955	2.47e-34	138.0	COG0244@1|root,COG0244@2|Bacteria,2G6XJ@200795|Chloroflexi,34CS6@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rplJ	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
PYH3_k127_6216581_5	1120973.AQXL01000133_gene1708	6.103e-128	420.0	COG0183@1|root,COG0183@2|Bacteria,1TT8U@1239|Firmicutes,4HDWF@91061|Bacilli,279X4@186823|Alicyclobacillaceae	91061|Bacilli	I	Thiolase, C-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
PYH3_k127_6216581_6	933262.AXAM01000050_gene3497	1.453e-106	361.0	COG1545@1|root,COG3425@1|root,COG1545@2|Bacteria,COG3425@2|Bacteria,1QV6D@1224|Proteobacteria,43DCP@68525|delta/epsilon subdivisions,2X8IQ@28221|Deltaproteobacteria,2MPP9@213118|Desulfobacterales	1224|Proteobacteria	I	Rubredoxin-like zinc ribbon domain (DUF35_N)	-	-	-	-	-	-	-	-	-	-	-	-	ACP_syn_III_C,DUF35_N,OB_aCoA_assoc
PYH3_k127_6216581_16	1048339.KB913029_gene2390	0.000171	44.0	COG0183@1|root,COG0183@2|Bacteria,2GIY0@201174|Actinobacteria,4EU8E@85013|Frankiales	201174|Actinobacteria	I	Thiolase, C-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
PYH3_k127_6221232_8	1168034.FH5T_14100	1.648e-142	464.0	COG0436@1|root,COG0436@2|Bacteria	2|Bacteria	E	Aminotransferase	bamJ	-	-	-	-	-	-	-	-	-	-	iSB619.SA_RS10050	Aminotran_1_2
PYH3_k127_6221232_10	1408423.JHYA01000012_gene1499	5.142e-131	428.0	COG1932@1|root,COG1932@2|Bacteria,1TP6Y@1239|Firmicutes,4H26T@909932|Negativicutes	909932|Negativicutes	E	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine	serC	-	2.6.1.52	ko:K00831	ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230	M00020,M00124	R04173,R05085	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
PYH3_k127_6221232_4	243164.DET0601	8.669e-161	516.0	COG0162@1|root,COG0162@2|Bacteria,2G64J@200795|Chloroflexi,34D17@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
PYH3_k127_6221232_18	311424.DhcVS_542	1.11e-75	265.0	COG0196@1|root,COG0196@2|Bacteria,2G6JF@200795|Chloroflexi,34D5G@301297|Dehalococcoidia	301297|Dehalococcoidia	H	Riboflavin kinase	ribF	-	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
PYH3_k127_6221232_22	555779.Dthio_PD3479	6.042e-43	167.0	COG0484@1|root,COG0484@2|Bacteria,1R9Y3@1224|Proteobacteria,42RBH@68525|delta/epsilon subdivisions,2WP1M@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	PFAM heat shock protein DnaJ domain protein	-	-	-	ko:K05516	-	-	-	-	ko00000,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C
PYH3_k127_6221232_13	255470.cbdbA796	1.204e-102	342.0	COG0207@1|root,COG0207@2|Bacteria,2G9SV@200795|Chloroflexi,34D5P@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Thymidylate synthase	-	-	2.1.1.45	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylat_synt
PYH3_k127_6221232_19	552811.Dehly_0676	1.511e-70	245.0	2CNXM@1|root,32QY5@2|Bacteria,2GAR9@200795|Chloroflexi,34D58@301297|Dehalococcoidia	301297|Dehalococcoidia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_6221232_24	255470.cbdbA799	8.148e-42	161.0	2E1WK@1|root,32X5T@2|Bacteria,2GASN@200795|Chloroflexi,34D99@301297|Dehalococcoidia	301297|Dehalococcoidia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_6221232_7	552811.Dehly_0236	7.31e-150	481.0	COG0031@1|root,COG0031@2|Bacteria,2G698@200795|Chloroflexi,34DQK@301297|Dehalococcoidia	200795|Chloroflexi	E	PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit	-	-	2.5.1.47,4.2.1.22	ko:K01697,ko:K01738,ko:K12339	ko00260,ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021,M00035,M00338	R00891,R00897,R01290,R03132,R03601,R04859,R04942	RC00020,RC00056,RC00069,RC00256,RC00489,RC01246,RC02814,RC02821,RC02876	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
PYH3_k127_6221232_32	1131462.DCF50_p1603	2.522e-08	59.0	2ENWS@1|root,33GHQ@2|Bacteria,1VQNU@1239|Firmicutes,24TC6@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_6221232_30	309799.DICTH_1705	7.236e-12	75.0	COG3809@1|root,COG3809@2|Bacteria	2|Bacteria	S	Transcription factor zinc-finger	-	-	-	ko:K09981	-	-	-	-	ko00000	-	-	-	zf-TFIIB
PYH3_k127_6221232_5	255470.cbdbA949	6.927e-157	508.0	COG0195@1|root,COG0195@2|Bacteria,2G5M5@200795|Chloroflexi,34CM6@301297|Dehalococcoidia	301297|Dehalococcoidia	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_5,NusA_N,S1
PYH3_k127_6221232_28	926569.ANT_02260	1.928e-19	91.0	COG2740@1|root,COG2740@2|Bacteria,2G72H@200795|Chloroflexi	200795|Chloroflexi	K	Protein of unknown function (DUF448)	-	-	-	ko:K07742	-	-	-	-	ko00000	-	-	-	DUF448
PYH3_k127_6221232_1	255470.cbdbA947	3.39e-228	721.0	COG0532@1|root,COG0532@2|Bacteria,2G5UR@200795|Chloroflexi,34CXP@301297|Dehalococcoidia	301297|Dehalococcoidia	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
PYH3_k127_6221232_26	1121422.AUMW01000003_gene949	2.181e-25	109.0	COG0858@1|root,COG0858@2|Bacteria,1VA0P@1239|Firmicutes,24MPB@186801|Clostridia,262H0@186807|Peptococcaceae	186801|Clostridia	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
PYH3_k127_6221232_17	1382306.JNIM01000001_gene2748	9.148e-76	264.0	COG0130@1|root,COG0130@2|Bacteria,2G6F4@200795|Chloroflexi	200795|Chloroflexi	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	-	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB-C_2,TruB_C,TruB_C_2,TruB_N
PYH3_k127_6221232_2	311424.DhcVS_852	1.895e-203	636.0	COG1260@1|root,COG1260@2|Bacteria,2G5YH@200795|Chloroflexi,34CJX@301297|Dehalococcoidia	301297|Dehalococcoidia	I	Myo-inositol-1-phosphate synthase	-	-	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth
PYH3_k127_6221232_9	552811.Dehly_0527	3.918e-133	434.0	COG0438@1|root,COG0438@2|Bacteria,2G61C@200795|Chloroflexi,34CIQ@301297|Dehalococcoidia	301297|Dehalococcoidia	M	Glycosyl transferases group 1	-	-	2.4.1.345	ko:K08256	-	-	R11702	-	ko00000,ko01000,ko01003	-	GT4	-	Glyco_transf_4,Glycos_transf_1
PYH3_k127_6221232_23	255470.cbdbA940	6.044e-43	165.0	COG0558@1|root,COG0558@2|Bacteria,2G6ZT@200795|Chloroflexi,34D5W@301297|Dehalococcoidia	301297|Dehalococcoidia	I	CDP-alcohol phosphatidyltransferase	-	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
PYH3_k127_6221232_6	697281.Mahau_0418	1.612e-150	487.0	COG0104@1|root,COG0104@2|Bacteria,1TQ4C@1239|Firmicutes,247RN@186801|Clostridia,42FKX@68295|Thermoanaerobacterales	186801|Clostridia	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
PYH3_k127_6221232_11	243164.DET0973	1.597e-128	416.0	COG0329@1|root,COG0329@2|Bacteria,2G6U3@200795|Chloroflexi,34CY7@301297|Dehalococcoidia	301297|Dehalococcoidia	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
PYH3_k127_6221232_12	552811.Dehly_0532	2.057e-112	374.0	COG0136@1|root,COG0136@2|Bacteria,2G5T9@200795|Chloroflexi,34CM5@301297|Dehalococcoidia	301297|Dehalococcoidia	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
PYH3_k127_6221232_16	311424.DhcVS_844	3.071e-86	293.0	COG0289@1|root,COG0289@2|Bacteria,2G7CZ@200795|Chloroflexi,34D6H@301297|Dehalococcoidia	301297|Dehalococcoidia	E	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate	dapB	-	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_C,DapB_N
PYH3_k127_6221232_0	255470.cbdbA932	9.65e-277	869.0	COG1185@1|root,COG1185@2|Bacteria,2G5TS@200795|Chloroflexi,34CYC@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004654,GO:0005488,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
PYH3_k127_6221232_25	500632.CLONEX_01532	5.865e-26	110.0	COG0184@1|root,COG0184@2|Bacteria,1VA5C@1239|Firmicutes,24MRM@186801|Clostridia	186801|Clostridia	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	-	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
PYH3_k127_6221232_29	311424.DhcVS_1244	2.881e-18	94.0	2EHX5@1|root,33BNR@2|Bacteria,2GATV@200795|Chloroflexi,34DBX@301297|Dehalococcoidia	301297|Dehalococcoidia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_6221232_31	1249975.JQLP01000001_gene3388	2.549e-10	70.0	2EHX5@1|root,3385X@2|Bacteria,4NVDX@976|Bacteroidetes,1I67H@117743|Flavobacteriia,2P72J@244698|Gillisia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_6221232_27	552811.Dehly_0005	1.104e-23	101.0	COG4481@1|root,COG4481@2|Bacteria,2G779@200795|Chloroflexi,34DIN@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Bacterial protein of unknown function (DUF951)	-	-	-	-	-	-	-	-	-	-	-	-	DUF951
PYH3_k127_6221232_15	1379698.RBG1_1C00001G0223	7.373e-88	298.0	COG0284@1|root,COG0284@2|Bacteria,2NP92@2323|unclassified Bacteria	2|Bacteria	F	Belongs to the OMP decarboxylase family. Type 2 subfamily	pyrF	GO:0003674,GO:0003824,GO:0004590,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.4.2.10,4.1.1.23	ko:K01591,ko:K13421	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00051	R00965,R01870,R08231	RC00063,RC00409,RC00611	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS17585	OMPdecase
PYH3_k127_6221232_14	255470.cbdbA1225	5.867e-95	319.0	COG0689@1|root,COG0689@2|Bacteria,2G69E@200795|Chloroflexi,34CXH@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates	rph	-	2.7.7.56	ko:K00989	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNase_PH,RNase_PH_C
PYH3_k127_6221232_20	479434.Sthe_2506	5.991e-55	210.0	COG0477@1|root,COG2814@2|Bacteria,2G6D7@200795|Chloroflexi	2|Bacteria	EGP	Major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
PYH3_k127_6221232_3	311424.DhcVS_1071	9.149e-171	546.0	COG0014@1|root,COG0014@2|Bacteria,2G5TY@200795|Chloroflexi,34CYU@301297|Dehalococcoidia	301297|Dehalococcoidia	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate	proA	-	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
PYH3_k127_6221232_21	222534.KB893715_gene1692	7.191e-45	168.0	COG1024@1|root,COG1024@2|Bacteria,2GJDK@201174|Actinobacteria,4EVGI@85013|Frankiales	201174|Actinobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
PYH3_k127_6289241_1	635013.TherJR_1303	3.826e-126	410.0	COG0309@1|root,COG0309@2|Bacteria,1TQP4@1239|Firmicutes,24963@186801|Clostridia,260QH@186807|Peptococcaceae	186801|Clostridia	O	hydrogenase expression formation protein HypE	hypE	-	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
PYH3_k127_6289241_3	1347087.CBYO010000017_gene2749	1.618e-52	194.0	COG0500@1|root,COG2226@2|Bacteria,1TR6N@1239|Firmicutes,4HEMY@91061|Bacilli	91061|Bacilli	Q	sAM-dependent methyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
PYH3_k127_6289241_4	1122611.KB903958_gene4061	1.225e-30	128.0	COG1051@1|root,COG1051@2|Bacteria,2I1PY@201174|Actinobacteria,4EP5A@85012|Streptosporangiales	201174|Actinobacteria	F	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
PYH3_k127_6289241_0	552811.Dehly_1412	1.077e-153	492.0	COG0409@1|root,COG0409@2|Bacteria,2G5MS@200795|Chloroflexi,34CKT@301297|Dehalococcoidia	301297|Dehalococcoidia	O	Hydrogenase formation hypA family	hypD	-	-	ko:K04654	-	-	-	-	ko00000	-	-	-	HypD
PYH3_k127_6289241_5	311424.DhcVS_1215	4.345e-18	85.0	COG0298@1|root,COG0298@2|Bacteria,2G7GW@200795|Chloroflexi,34DI4@301297|Dehalococcoidia	301297|Dehalococcoidia	O	HupF/HypC family	hypC	-	-	ko:K04653	-	-	-	-	ko00000	-	-	-	HupF_HypC
PYH3_k127_6289241_2	552811.Dehly_1410	4.113e-102	342.0	COG0068@1|root,COG0068@2|Bacteria,2G5QN@200795|Chloroflexi,34CJB@301297|Dehalococcoidia	301297|Dehalococcoidia	O	Telomere recombination	hypF	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
PYH3_k127_6317449_3	936596.HMPREF1495_1175	1.274e-39	153.0	COG2025@1|root,COG2025@2|Bacteria,1TPC8@1239|Firmicutes,247NF@186801|Clostridia,1HW2E@1164882|Lachnoanaerobaculum	186801|Clostridia	C	Electron transfer flavoprotein domain	etfA_2	-	1.3.1.108	ko:K03522,ko:K22432	-	-	-	-	ko00000,ko01000,ko04147	-	-	-	ETF,ETF_alpha,Fer4
PYH3_k127_6317449_4	1379698.RBG1_1C00001G1822	4.578e-35	145.0	COG2086@1|root,COG2086@2|Bacteria,2NP4J@2323|unclassified Bacteria	2|Bacteria	C	Electron transfer flavoprotein	etfB	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016020,GO:0016491,GO:0022900,GO:0030312,GO:0040007,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071944	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
PYH3_k127_6317449_0	640511.BC1002_6699	1.845e-86	305.0	COG1032@1|root,COG1032@2|Bacteria,1R92G@1224|Proteobacteria,2WB71@28216|Betaproteobacteria,1K09Q@119060|Burkholderiaceae	28216|Betaproteobacteria	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
PYH3_k127_6317449_2	237368.SCABRO_02137	1.142e-65	253.0	COG0644@1|root,COG0644@2|Bacteria	2|Bacteria	C	geranylgeranyl reductase activity	prnA	-	1.14.19.9	ko:K14266	ko00404,ko01130,map00404,map01130	M00789,M00790	R09570	RC00949	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_halogenase
PYH3_k127_6317449_1	525904.Tter_0593	2.39e-78	292.0	COG1252@1|root,COG1252@2|Bacteria,2NP3T@2323|unclassified Bacteria	2|Bacteria	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	ndh	-	1.6.99.3	ko:K03885,ko:K15977	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
PYH3_k127_6317449_5	408672.NBCG_02581	1.12e-12	73.0	COG2318@1|root,COG2318@2|Bacteria,2II1I@201174|Actinobacteria,4DR3V@85009|Propionibacteriales	201174|Actinobacteria	S	Protein of unknown function (DUF664)	-	-	-	-	-	-	-	-	-	-	-	-	DUF664,DinB_2
PYH3_k127_6335615_1	552811.Dehly_0756	1.103e-187	613.0	COG1193@1|root,COG1193@2|Bacteria,2G5R8@200795|Chloroflexi	200795|Chloroflexi	L	Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity	mutS2	-	-	ko:K07456	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_III,MutS_V,Smr
PYH3_k127_6335615_0	1125863.JAFN01000001_gene1819	5.83e-306	948.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,42MHP@68525|delta/epsilon subdivisions,2WJY2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.17	ko:K01908	ko00640,ko01100,map00640,map01100	-	R00926,R01354	RC00004,RC00043,RC00070,RC02816	ko00000,ko00001,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
PYH3_k127_6335615_3	326423.RBAM_021680	4.447e-136	448.0	COG0281@1|root,COG0281@2|Bacteria,1UYHB@1239|Firmicutes,4HDRG@91061|Bacilli,1ZDC7@1386|Bacillus	91061|Bacilli	C	malic enzyme	mleA	-	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	-	R00214	RC00105	ko00000,ko00001,ko01000	-	-	-	2-Hacid_dh_C,ACT_4,Malic_M,THF_DHG_CYH_C,malic
PYH3_k127_6335615_5	335543.Sfum_0989	1.072e-111	372.0	COG0624@1|root,COG0624@2|Bacteria,1MVBR@1224|Proteobacteria,42MY5@68525|delta/epsilon subdivisions,2WKST@28221|Deltaproteobacteria,2MQY9@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	Peptidase dimerisation domain	argE	-	3.5.1.16	ko:K01438	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R00669,R09107	RC00064,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
PYH3_k127_6335615_9	335543.Sfum_0988	4.462e-45	169.0	COG0454@1|root,COG0456@2|Bacteria,1RF31@1224|Proteobacteria,42RUB@68525|delta/epsilon subdivisions,2WN97@28221|Deltaproteobacteria,2MS1U@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
PYH3_k127_6335615_8	311424.DhcVS_1228	4.265e-53	193.0	COG2095@1|root,COG2095@2|Bacteria,2G938@200795|Chloroflexi,34D5D@301297|Dehalococcoidia	301297|Dehalococcoidia	U	MarC family integral membrane protein	-	-	-	ko:K05595	-	-	-	-	ko00000,ko02000	2.A.95.1	-	-	MarC
PYH3_k127_6335615_10	552811.Dehly_0997	7.661e-39	151.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	2.3.1.82	ko:K18815	-	-	-	-	br01600,ko00000,ko01000,ko01504	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_7
PYH3_k127_6335615_7	552811.Dehly_0996	4.316e-73	259.0	COG1181@1|root,COG1181@2|Bacteria,2G5RS@200795|Chloroflexi,34CTK@301297|Dehalococcoidia	2|Bacteria	F	Belongs to the D-alanine--D-alanine ligase family	ddlB1	-	6.3.2.4,6.3.5.5	ko:K01921,ko:K01955	ko00240,ko00250,ko00473,ko00550,ko01100,ko01502,map00240,map00250,map00473,map00550,map01100,map01502	M00051	R00256,R00575,R01150,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC00064,RC00141,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
PYH3_k127_6335615_4	311424.DhcVS_570	1.436e-112	372.0	COG1181@1|root,COG1181@2|Bacteria,2G5RS@200795|Chloroflexi,34CTK@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Belongs to the D-alanine--D-alanine ligase family	-	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
PYH3_k127_6335615_2	243164.DET0628	2.545e-161	520.0	COG1509@1|root,COG1509@2|Bacteria,2GBVD@200795|Chloroflexi,34CXT@301297|Dehalococcoidia	301297|Dehalococcoidia	C	4Fe-4S single cluster domain	-	-	5.4.3.2	ko:K01843	ko00310,map00310	-	R00461	RC00303	ko00000,ko00001,ko01000	-	-	-	Fer4_14,LAM_C,Radical_SAM
PYH3_k127_6335615_6	255470.cbdbA860	1.443e-99	341.0	COG2211@1|root,COG2211@2|Bacteria,2G6WX@200795|Chloroflexi,34CJ4@301297|Dehalococcoidia	301297|Dehalococcoidia	G	MFS_1 like family	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
PYH3_k127_6335615_11	1211815.CBYP010000063_gene1857	6.517e-28	120.0	COG3173@1|root,COG3173@2|Bacteria,2GMZQ@201174|Actinobacteria,4EXAK@85013|Frankiales	201174|Actinobacteria	S	Ecdysteroid kinase	-	-	-	-	-	-	-	-	-	-	-	-	APH,EcKinase
PYH3_k127_6393230_3	994573.T472_0206040	8.03e-25	108.0	2DTR7@1|root,33MCI@2|Bacteria,1W5BS@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_6393230_4	1499967.BAYZ01000188_gene3884	3.776e-21	101.0	COG1765@1|root,COG1765@2|Bacteria	2|Bacteria	O	OsmC-like protein	-	-	-	ko:K07397	-	-	-	-	ko00000	-	-	-	DUF3795,OsmC
PYH3_k127_6393230_5	243164.DET1468	1.3e-12	70.0	2A4EM@1|root,30T0F@2|Bacteria,2GAWC@200795|Chloroflexi,34DH1@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Zinc ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
PYH3_k127_6393230_2	552811.Dehly_1333	2.088e-85	292.0	COG1235@1|root,COG1235@2|Bacteria,2G9K1@200795|Chloroflexi,34CQD@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
PYH3_k127_6393230_0	311424.DhcVS_1511	5.172e-232	733.0	COG1032@1|root,COG1032@2|Bacteria,2G5N0@200795|Chloroflexi,34CUW@301297|Dehalococcoidia	301297|Dehalococcoidia	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
PYH3_k127_6393230_1	383381.EH30_04415	8.045e-100	345.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VFYM@28211|Alphaproteobacteria,2KE0H@204457|Sphingomonadales	204457|Sphingomonadales	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
PYH3_k127_6432807_11	255470.cbdbA1385	4.525e-95	326.0	COG0037@1|root,COG0037@2|Bacteria,2G6AD@200795|Chloroflexi,34CWT@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3,TilS_C
PYH3_k127_6432807_27	552811.Dehly_1416	1.202e-53	196.0	COG5011@1|root,COG5011@2|Bacteria,2G71I@200795|Chloroflexi,34CJ6@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Uncharacterized protein conserved in bacteria (DUF2344)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2344
PYH3_k127_6432807_9	1121430.JMLG01000001_gene2316	1.936e-108	361.0	COG2070@1|root,COG2070@2|Bacteria,1TPC3@1239|Firmicutes,24831@186801|Clostridia,263EG@186807|Peptococcaceae	186801|Clostridia	S	IMP dehydrogenase / GMP reductase domain	-	-	1.13.12.16,1.3.1.9	ko:K00459,ko:K02371	ko00061,ko00910,ko01100,ko01212,map00061,map00910,map01100,map01212	M00083	R00025,R04429,R04724,R04955,R04958,R04961,R04966,R04969,R07765	RC00052,RC00076,RC02541,RC02759	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	NMO
PYH3_k127_6432807_0	311424.DhcVS_544	0.0	1729.0	COG0086@1|root,COG0086@2|Bacteria,2G632@200795|Chloroflexi,34CZR@301297|Dehalococcoidia	301297|Dehalococcoidia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
PYH3_k127_6432807_1	309801.trd_0991	0.0	1416.0	COG0085@1|root,COG0085@2|Bacteria,2G5VH@200795|Chloroflexi,27XNX@189775|Thermomicrobia	189775|Thermomicrobia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
PYH3_k127_6432807_54	518766.Rmar_1812	4.013e-19	89.0	COG1254@1|root,COG1254@2|Bacteria,4NVB4@976|Bacteroidetes,1FJMR@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	C	Acylphosphatase	acyP	-	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	-	R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000	-	-	-	Acylphosphatase
PYH3_k127_6432807_58	926550.CLDAP_23410	2.409e-08	61.0	2FJCP@1|root,34B2I@2|Bacteria,2G94J@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_6432807_10	552811.Dehly_0415	4.543e-99	328.0	COG2006@1|root,COG2006@2|Bacteria,2GBW5@200795|Chloroflexi,34D28@301297|Dehalococcoidia	301297|Dehalococcoidia	S	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
PYH3_k127_6432807_24	909663.KI867151_gene3156	1.508e-60	215.0	COG2220@1|root,COG2220@2|Bacteria,1QB9E@1224|Proteobacteria,42N7W@68525|delta/epsilon subdivisions,2WNMC@28221|Deltaproteobacteria,2MQPI@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
PYH3_k127_6432807_6	1123288.SOV_4c07550	2.228e-150	490.0	COG0260@1|root,COG0260@2|Bacteria,1TPJZ@1239|Firmicutes,4H3I7@909932|Negativicutes	909932|Negativicutes	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
PYH3_k127_6432807_3	986075.CathTA2_1639	8.607e-204	651.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,4HFIP@91061|Bacilli	1239|Firmicutes	C	Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
PYH3_k127_6432807_42	255470.cbdbA1002	6.005e-36	144.0	COG0645@1|root,COG0645@2|Bacteria,2GBGC@200795|Chloroflexi,34CRH@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Chromatin associated protein KTI12	-	-	-	-	-	-	-	-	-	-	-	-	AAA_33
PYH3_k127_6432807_34	255470.cbdbA1004	7.433e-44	171.0	COG1307@1|root,COG1307@2|Bacteria,2G6PH@200795|Chloroflexi,34D2V@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Dihydroxyacetone kinase family	-	-	-	-	-	-	-	-	-	-	-	-	DegV
PYH3_k127_6432807_37	309801.trd_A0580	4.28e-42	166.0	COG1307@1|root,COG1307@2|Bacteria,2G6PH@200795|Chloroflexi,27YU3@189775|Thermomicrobia	189775|Thermomicrobia	S	Uncharacterised protein, DegV family COG1307	-	-	-	-	-	-	-	-	-	-	-	-	DegV
PYH3_k127_6432807_47	485916.Dtox_2175	4.259e-27	113.0	COG1695@1|root,COG1695@2|Bacteria,1TTPI@1239|Firmicutes,25N2N@186801|Clostridia,26582@186807|Peptococcaceae	186801|Clostridia	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
PYH3_k127_6432807_46	1123009.AUID01000020_gene120	3.628e-30	121.0	COG0228@1|root,COG0228@2|Bacteria,1VA0X@1239|Firmicutes,24MND@186801|Clostridia,269IJ@186813|unclassified Clostridiales	186801|Clostridia	J	Ribosomal protein S16	rpsP	-	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
PYH3_k127_6432807_51	552811.Dehly_0553	5.51e-23	102.0	COG1837@1|root,COG1837@2|Bacteria,2G7DU@200795|Chloroflexi,34DG8@301297|Dehalococcoidia	301297|Dehalococcoidia	S	KH domain	-	-	-	ko:K06960	-	-	-	-	ko00000	-	-	-	KH_4
PYH3_k127_6432807_19	1380346.JNIH01000056_gene138	1.709e-69	254.0	COG0515@1|root,COG1520@1|root,COG0515@2|Bacteria,COG1520@2|Bacteria,2GIV0@201174|Actinobacteria	201174|Actinobacteria	KLT	serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,PQQ_3,Pkinase
PYH3_k127_6432807_30	1089553.Tph_c18380	5.207e-48	175.0	COG0780@1|root,COG0780@2|Bacteria,1TPYC@1239|Firmicutes,24BYP@186801|Clostridia,42G8V@68295|Thermoanaerobacterales	186801|Clostridia	F	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)	queF	-	1.7.1.13	ko:K09457	ko00790,ko01100,map00790,map01100	-	R07605	RC01875	ko00000,ko00001,ko01000,ko03016	-	-	-	QueF
PYH3_k127_6432807_52	41431.PCC8801_0803	2.686e-21	100.0	2E3GU@1|root,32YFI@2|Bacteria,1G9HI@1117|Cyanobacteria,3KIKQ@43988|Cyanothece	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_6432807_5	255470.cbdbA72	6.453e-169	541.0	COG1066@1|root,COG1066@2|Bacteria,2G5TE@200795|Chloroflexi,34CSA@301297|Dehalococcoidia	301297|Dehalococcoidia	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	ATPase,ChlI
PYH3_k127_6432807_53	634498.mru_0594	4.191e-20	96.0	COG0622@1|root,arCOG01141@2157|Archaea,2XWQ0@28890|Euryarchaeota,23PK2@183925|Methanobacteria	183925|Methanobacteria	S	Phosphoesterase	-	-	-	ko:K07095	-	-	-	-	ko00000	-	-	-	Metallophos_2
PYH3_k127_6432807_15	552811.Dehly_1589	1.046e-74	258.0	COG2231@1|root,COG2231@2|Bacteria,2G92S@200795|Chloroflexi,34CVI@301297|Dehalococcoidia	301297|Dehalococcoidia	L	endonuclease III	-	-	-	ko:K07457	-	-	-	-	ko00000	-	-	-	HhH-GPD
PYH3_k127_6432807_36	552811.Dehly_1590	2.744e-42	160.0	COG1720@1|root,COG1720@2|Bacteria,2G799@200795|Chloroflexi,34DAJ@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Uncharacterised protein family UPF0066	-	-	-	-	-	-	-	-	-	-	-	-	UPF0066
PYH3_k127_6432807_35	552811.Dehly_1065	2.994e-43	161.0	COG0103@1|root,COG0103@2|Bacteria,2G6UZ@200795|Chloroflexi,34DBY@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Belongs to the universal ribosomal protein uS9 family	rpsI	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
PYH3_k127_6432807_32	502558.EGYY_23880	4.908e-46	170.0	COG0102@1|root,COG0102@2|Bacteria,2IFG1@201174|Actinobacteria,4CVR4@84998|Coriobacteriia	84998|Coriobacteriia	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	-	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
PYH3_k127_6432807_20	243164.DET0504	1.584e-66	235.0	COG0101@1|root,COG0101@2|Bacteria,2G6PE@200795|Chloroflexi,34CX3@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	-	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
PYH3_k127_6432807_40	552811.Dehly_1068	2.705e-41	154.0	COG0203@1|root,COG0203@2|Bacteria,2G79I@200795|Chloroflexi,34DCI@301297|Dehalococcoidia	301297|Dehalococcoidia	J	structural constituent of ribosome	rplQ	-	-	ko:K02879	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L17
PYH3_k127_6432807_8	243164.DET0502	4.558e-110	365.0	COG0202@1|root,COG0202@2|Bacteria,2G5M9@200795|Chloroflexi,34CIJ@301297|Dehalococcoidia	301297|Dehalococcoidia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	GO:0003674,GO:0003824,GO:0003899,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
PYH3_k127_6432807_21	311424.DhcVS_443	1.344e-65	232.0	COG0522@1|root,COG0522@2|Bacteria,2G6AZ@200795|Chloroflexi,34CMS@301297|Dehalococcoidia	301297|Dehalococcoidia	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	-	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
PYH3_k127_6432807_26	311424.DhcVS_442	6.36e-55	195.0	COG0100@1|root,COG0100@2|Bacteria,2G6HG@200795|Chloroflexi,34DAY@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome	rpsK	-	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
PYH3_k127_6432807_31	552811.Dehly_1072	3.612e-46	170.0	COG0099@1|root,COG0099@2|Bacteria,2G6PF@200795|Chloroflexi,34DBP@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	-	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
PYH3_k127_6432807_56	1111131.HMPREF1255_0176	9.374e-13	68.0	COG0257@1|root,COG0257@2|Bacteria,2GWMH@201174|Actinobacteria	201174|Actinobacteria	J	Belongs to the bacterial ribosomal protein bL36 family	rpmJ	-	-	ko:K02919	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L36
PYH3_k127_6432807_45	643648.Slip_2213	2.183e-32	127.0	COG0361@1|root,COG0361@2|Bacteria,1V9ZK@1239|Firmicutes,24MQE@186801|Clostridia,42K3D@68298|Syntrophomonadaceae	186801|Clostridia	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	-	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
PYH3_k127_6432807_12	255470.cbdbA460	2.19e-93	314.0	COG0024@1|root,COG0024@2|Bacteria,2G6AV@200795|Chloroflexi,34CJJ@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Metallopeptidase family M24	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
PYH3_k127_6432807_17	1123371.ATXH01000034_gene775	6.993e-72	248.0	COG0563@1|root,COG0563@2|Bacteria,2GGXU@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK,ADK_lid
PYH3_k127_6432807_4	552811.Dehly_1077	4.272e-175	559.0	COG0201@1|root,COG0201@2|Bacteria,2G5X4@200795|Chloroflexi,34CNS@301297|Dehalococcoidia	301297|Dehalococcoidia	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
PYH3_k127_6432807_39	255470.cbdbA457	7.817e-42	158.0	COG0200@1|root,COG0200@2|Bacteria,2G6T9@200795|Chloroflexi,34CY2@301297|Dehalococcoidia	301297|Dehalococcoidia	J	binds to the 23S rRNA	rplO	-	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
PYH3_k127_6432807_55	1128421.JAGA01000002_gene715	2.443e-18	87.0	COG1841@1|root,COG1841@2|Bacteria,2NQ1P@2323|unclassified Bacteria	2|Bacteria	J	Ribosomal protein L30	rpmD	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
PYH3_k127_6432807_22	552811.Dehly_1080	1.482e-62	219.0	COG0098@1|root,COG0098@2|Bacteria,2G6M9@200795|Chloroflexi,34CXU@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body	rpsE	-	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
PYH3_k127_6432807_41	309799.DICTH_0853	1.504e-38	147.0	COG0256@1|root,COG0256@2|Bacteria	2|Bacteria	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rplR	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18p
PYH3_k127_6432807_23	558169.AGAV01000001_gene3304	6.243e-62	218.0	COG0097@1|root,COG0097@2|Bacteria,1V1FC@1239|Firmicutes,4HFQD@91061|Bacilli	91061|Bacilli	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rplF	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
PYH3_k127_6432807_29	255470.cbdbA452	3.643e-49	179.0	COG0096@1|root,COG0096@2|Bacteria,2G6XS@200795|Chloroflexi,34DBD@301297|Dehalococcoidia	301297|Dehalococcoidia	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rpsH	-	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
PYH3_k127_6432807_49	515635.Dtur_0994	1.181e-25	107.0	COG0199@1|root,COG0199@2|Bacteria	2|Bacteria	J	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site	rpsN	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
PYH3_k127_6432807_16	273068.TTE2279	1.577e-74	254.0	COG0094@1|root,COG0094@2|Bacteria,1TPE0@1239|Firmicutes,247X0@186801|Clostridia,42F2S@68295|Thermoanaerobacterales	186801|Clostridia	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rplE	-	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
PYH3_k127_6432807_38	255470.cbdbA450	7.113e-42	155.0	COG0198@1|root,COG0198@2|Bacteria,2G750@200795|Chloroflexi,34DCX@301297|Dehalococcoidia	301297|Dehalococcoidia	J	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit	rplX	-	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,ribosomal_L24
PYH3_k127_6432807_28	1341157.RF007C_14210	7.936e-53	189.0	COG0093@1|root,COG0093@2|Bacteria,1V3N0@1239|Firmicutes,24H98@186801|Clostridia,3WITX@541000|Ruminococcaceae	186801|Clostridia	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rplN	-	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
PYH3_k127_6432807_50	903814.ELI_4026	3.057e-23	103.0	COG0186@1|root,COG0186@2|Bacteria,1V9YC@1239|Firmicutes,24MSW@186801|Clostridia,25WUN@186806|Eubacteriaceae	186801|Clostridia	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rpsQ	-	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
PYH3_k127_6432807_57	243164.DET0482	8.804e-11	64.0	COG0255@1|root,COG0255@2|Bacteria,2G7DB@200795|Chloroflexi,34DH7@301297|Dehalococcoidia	301297|Dehalococcoidia	J	structural constituent of ribosome	rpmC	-	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
PYH3_k127_6432807_25	255470.cbdbA446	1.38e-55	198.0	COG0197@1|root,COG0197@2|Bacteria,2G6NA@200795|Chloroflexi,34DDJ@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs	rplP	-	-	ko:K02878	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
PYH3_k127_6432807_13	552811.Dehly_1091	4.604e-88	302.0	COG0092@1|root,COG0092@2|Bacteria,2G691@200795|Chloroflexi,34CS1@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	-	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
PYH3_k127_6432807_44	552811.Dehly_1092	9.395e-34	134.0	COG0091@1|root,COG0091@2|Bacteria,2G6ZQ@200795|Chloroflexi,34DE4@301297|Dehalococcoidia	301297|Dehalococcoidia	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rplV	-	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
PYH3_k127_6432807_43	552811.Dehly_1093	1.626e-35	137.0	COG0185@1|root,COG0185@2|Bacteria,2G6US@200795|Chloroflexi,34DEQ@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rpsS	-	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
PYH3_k127_6432807_7	926569.ANT_10070	3.2e-130	420.0	COG0090@1|root,COG0090@2|Bacteria,2G65E@200795|Chloroflexi	200795|Chloroflexi	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
PYH3_k127_6432807_48	552811.Dehly_1095	1.893e-26	111.0	COG0089@1|root,COG0089@2|Bacteria,2G73T@200795|Chloroflexi,34DEW@301297|Dehalococcoidia	301297|Dehalococcoidia	J	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome	rplW	-	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
PYH3_k127_6432807_18	311424.DhcVS_418	2.046e-71	247.0	COG0088@1|root,COG0088@2|Bacteria,2G6K2@200795|Chloroflexi,34CM4@301297|Dehalococcoidia	301297|Dehalococcoidia	J	50S ribosomal protein L4	rplD	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02926	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
PYH3_k127_6432807_14	552811.Dehly_1097	5.172e-84	283.0	COG0087@1|root,COG0087@2|Bacteria,2G6DQ@200795|Chloroflexi,34D7B@301297|Dehalococcoidia	301297|Dehalococcoidia	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
PYH3_k127_6432807_33	552811.Dehly_1098	3.026e-45	165.0	COG0051@1|root,COG0051@2|Bacteria,2G6RB@200795|Chloroflexi,34DED@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Involved in the binding of tRNA to the ribosomes	rpsJ	-	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
PYH3_k127_6432807_2	243164.DET0472	1.166e-277	868.0	COG0480@1|root,COG0480@2|Bacteria,2G63B@200795|Chloroflexi,34CYQ@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
PYH3_k127_6441714_2	357808.RoseRS_2799	8.115e-32	139.0	COG1840@1|root,COG2304@1|root,COG1840@2|Bacteria,COG2304@2|Bacteria,2G7PB@200795|Chloroflexi,376FM@32061|Chloroflexia	32061|Chloroflexia	P	PFAM von Willebrand factor type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	SBP_bac_11,VWA
PYH3_k127_6441714_4	391587.KAOT1_01420	2.313e-18	96.0	COG3509@1|root,COG3509@2|Bacteria	2|Bacteria	Q	xylan catabolic process	-	-	-	ko:K03932	-	-	-	-	ko00000	-	CE1	-	Abhydrolase_2,CBM_2,CBM_4_9,Esterase_phd,Glyco_hydro_16,RicinB_lectin_2,SLH
PYH3_k127_6441714_1	1499680.CCFE01000023_gene2574	1.04e-82	289.0	COG1804@1|root,COG1804@2|Bacteria,1TP54@1239|Firmicutes,4HABI@91061|Bacilli,1ZM1F@1386|Bacillus	91061|Bacilli	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
PYH3_k127_6441714_0	1499680.CCFE01000023_gene2573	4.657e-106	358.0	COG1804@1|root,COG1804@2|Bacteria,1TP54@1239|Firmicutes,4HABI@91061|Bacilli,1ZM1C@1386|Bacillus	91061|Bacilli	C	CoA-transferase family III	frc	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
PYH3_k127_6441714_6	994479.GL877882_gene6848	1.146e-06	56.0	COG2030@1|root,COG2030@2|Bacteria,2GXE5@201174|Actinobacteria	201174|Actinobacteria	I	dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
PYH3_k127_6441714_8	875328.JDM601_3748	2.199e-05	52.0	COG2030@1|root,COG2030@2|Bacteria,2IRY8@201174|Actinobacteria,2390Z@1762|Mycobacteriaceae	201174|Actinobacteria	I	MaoC like domain	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
PYH3_k127_6441714_5	552811.Dehly_0412	4.962e-13	72.0	COG3462@1|root,COG3462@2|Bacteria,2G9MX@200795|Chloroflexi,34DHS@301297|Dehalococcoidia	2|Bacteria	S	Short C-terminal domain	-	-	-	ko:K08982	-	-	-	-	ko00000	-	-	-	SHOCT
PYH3_k127_6441714_3	404589.Anae109_1645	5.219e-19	91.0	COG3427@1|root,COG3427@2|Bacteria,1PB5Q@1224|Proteobacteria	1224|Proteobacteria	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
PYH3_k127_6488687_4	1121422.AUMW01000014_gene1319	2.582e-23	105.0	COG1960@1|root,COG1960@2|Bacteria,1TP57@1239|Firmicutes,247UB@186801|Clostridia	186801|Clostridia	C	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
PYH3_k127_6488687_2	266117.Rxyl_0351	4.099e-58	214.0	COG1063@1|root,COG1063@2|Bacteria,2GKC7@201174|Actinobacteria,4CTE8@84995|Rubrobacteria	84995|Rubrobacteria	E	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
PYH3_k127_6488687_1	632292.Calhy_1969	7.404e-61	218.0	COG0321@1|root,COG0321@2|Bacteria,1V44P@1239|Firmicutes,24GE9@186801|Clostridia,42FUN@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate	lipB	-	2.3.1.181	ko:K03801	ko00785,ko01100,map00785,map01100	-	R07766,R07769	RC00039,RC00992,RC02867	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
PYH3_k127_6488687_0	264732.Moth_1762	5.097e-105	349.0	COG0320@1|root,COG0320@2|Bacteria,1TQM4@1239|Firmicutes,2495Q@186801|Clostridia,42EQR@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	-	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB,LIAS_N,Radical_SAM
PYH3_k127_6488687_3	1123288.SOV_7c00320	8.312e-55	207.0	COG0277@1|root,COG0277@2|Bacteria,1V0MY@1239|Firmicutes,4H6RT@909932|Negativicutes	909932|Negativicutes	C	FAD linked oxidases, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD-oxidase_C,FAD_binding_4
PYH3_k127_6501872_4	517722.AEUE01000001_gene2842	3.132e-24	104.0	COG1028@1|root,COG1028@2|Bacteria,1MXNQ@1224|Proteobacteria,2TS6G@28211|Alphaproteobacteria,2KCNC@204457|Sphingomonadales	204457|Sphingomonadales	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
PYH3_k127_6501872_0	1122918.KB907249_gene3890	1.974e-172	558.0	COG2936@1|root,COG2936@2|Bacteria,1TT0H@1239|Firmicutes,4HC37@91061|Bacilli,26TMF@186822|Paenibacillaceae	91061|Bacilli	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
PYH3_k127_6501872_3	479434.Sthe_0127	3.889e-28	121.0	COG0526@1|root,COG0526@2|Bacteria,2G8YT@200795|Chloroflexi,27YFH@189775|Thermomicrobia	200795|Chloroflexi	CO	Thioredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_9
PYH3_k127_6501872_5	1122921.KB898197_gene1269	8.505e-05	48.0	COG0695@1|root,COG0695@2|Bacteria,1VGHM@1239|Firmicutes,4HQ0H@91061|Bacilli,26YY5@186822|Paenibacillaceae	91061|Bacilli	O	Glutaredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Glutaredoxin
PYH3_k127_6501872_1	255470.cbdbA1278	2.268e-92	309.0	COG0106@1|root,COG0106@2|Bacteria,2G6EC@200795|Chloroflexi,34CVB@301297|Dehalococcoidia	301297|Dehalococcoidia	E	1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity	hisA	GO:0000105,GO:0003674,GO:0003824,GO:0003949,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
PYH3_k127_6501872_2	760568.Desku_2605	5.528e-92	308.0	COG4799@1|root,COG4799@2|Bacteria,1TQCV@1239|Firmicutes,247WG@186801|Clostridia,25ZXW@186807|Peptococcaceae	186801|Clostridia	I	acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)	-	-	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
PYH3_k127_6568891_7	1514668.JOOA01000002_gene3304	5.264e-19	89.0	COG0564@1|root,COG0564@2|Bacteria,1TPCM@1239|Firmicutes,247Y2@186801|Clostridia,3WGKV@541000|Ruminococcaceae	186801|Clostridia	J	Responsible for synthesis of pseudouridine from uracil	rluD	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
PYH3_k127_6568891_6	552811.Dehly_0107	1.114e-23	108.0	COG0597@1|root,COG0597@2|Bacteria,2G740@200795|Chloroflexi,34DBG@301297|Dehalococcoidia	301297|Dehalococcoidia	M	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	lspA	-	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
PYH3_k127_6568891_5	255470.cbdbA1326	1.548e-29	121.0	COG1734@1|root,COG1734@2|Bacteria,2GAUG@200795|Chloroflexi,34DDM@301297|Dehalococcoidia	301297|Dehalococcoidia	T	Prokaryotic dksA/traR C4-type zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-dskA_traR
PYH3_k127_6568891_4	1410670.JHXF01000005_gene1029	4.316e-30	123.0	COG1917@1|root,COG1917@2|Bacteria,1V8SS@1239|Firmicutes,24KI9@186801|Clostridia	186801|Clostridia	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
PYH3_k127_6568891_2	255470.cbdbA1735	5.522e-86	293.0	COG1694@1|root,COG3956@2|Bacteria,2G5WH@200795|Chloroflexi,34D6B@301297|Dehalococcoidia	301297|Dehalococcoidia	S	MazG nucleotide pyrophosphohydrolase domain	-	-	-	ko:K02499	-	-	-	-	ko00000,ko03036	-	-	-	MazG
PYH3_k127_6568891_1	552811.Dehly_1722	1.188e-94	321.0	COG0223@1|root,COG0223@2|Bacteria,2G69J@200795|Chloroflexi,34CZA@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
PYH3_k127_6568891_0	243164.DET0001	7.21e-143	466.0	COG0593@1|root,COG0593@2|Bacteria,2G5W8@200795|Chloroflexi,34CS8@301297|Dehalococcoidia	301297|Dehalococcoidia	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	-	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
PYH3_k127_6568891_3	552811.Dehly_1339	1.038e-82	282.0	COG0536@1|root,COG0536@2|Bacteria,2G5ZT@200795|Chloroflexi,34CK2@301297|Dehalococcoidia	301297|Dehalococcoidia	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	DUF1967,GTP1_OBG,MMR_HSR1
PYH3_k127_6705210_6	706587.Desti_4517	1.564e-31	127.0	COG1053@1|root,COG1053@2|Bacteria,1R478@1224|Proteobacteria,42PCT@68525|delta/epsilon subdivisions,2WJIG@28221|Deltaproteobacteria,2MR41@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	FAD binding domain	-	-	1.3.5.1,1.3.5.4,1.4.3.16	ko:K00239,ko:K00278	ko00020,ko00190,ko00250,ko00650,ko00720,ko00760,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00250,map00650,map00720,map00760,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00115,M00149,M00173,M00374,M00376	R00357,R00481,R02164	RC00006,RC00045,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2
PYH3_k127_6705210_5	589924.Ferp_2206	1.294e-32	136.0	COG5423@1|root,arCOG04361@2157|Archaea,2Y00P@28890|Euryarchaeota	28890|Euryarchaeota	S	Predicted metal-binding protein (DUF2284)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2284
PYH3_k127_6705210_1	760568.Desku_0503	3.987e-131	428.0	COG0119@1|root,COG0119@2|Bacteria,1TQG3@1239|Firmicutes,24AUV@186801|Clostridia,264RD@186807|Peptococcaceae	186801|Clostridia	E	HMGL-like	mvaB	-	4.1.3.4	ko:K01640	ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146	M00036,M00088	R01360,R08090	RC00502,RC00503,RC01118,RC01946	ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
PYH3_k127_6705210_3	266117.Rxyl_2054	3.942e-47	179.0	COG1024@1|root,COG1024@2|Bacteria,2HHR6@201174|Actinobacteria,4CU2T@84995|Rubrobacteria	84995|Rubrobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
PYH3_k127_6705210_0	760568.Desku_0178	2.005e-287	896.0	COG0365@1|root,COG0365@2|Bacteria,1TQTI@1239|Firmicutes,24DPN@186801|Clostridia,260G2@186807|Peptococcaceae	186801|Clostridia	I	TIGRFAM Acetoacetyl-CoA synthase	-	-	6.2.1.16	ko:K01907	ko00280,ko00650,map00280,map00650	-	R01357	RC00004,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
PYH3_k127_6705210_2	986075.CathTA2_1922	6.756e-93	318.0	COG1960@1|root,COG1960@2|Bacteria,1TPVK@1239|Firmicutes,4HA7B@91061|Bacilli	91061|Bacilli	I	Dehydrogenase	B4168_2380	-	1.3.99.32	ko:K16173	ko00362,ko01120,map00362,map01120	-	R05579	RC00052	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
PYH3_k127_6705210_4	1463861.JNXE01000001_gene5163	7.883e-40	152.0	COG1960@1|root,COG1960@2|Bacteria,2GKVN@201174|Actinobacteria	201174|Actinobacteria	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
PYH3_k127_6713840_0	311424.DhcVS_50	1.344e-218	704.0	COG0013@1|root,COG0013@2|Bacteria,2G5KW@200795|Chloroflexi,34CVN@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
PYH3_k127_6713840_12	349161.Dred_0775	5.485e-27	115.0	COG0816@1|root,COG0816@2|Bacteria,1V6ER@1239|Firmicutes,24JGP@186801|Clostridia,2622P@186807|Peptococcaceae	186801|Clostridia	J	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA	yrrK	-	-	ko:K07447	-	-	-	-	ko00000,ko01000	-	-	-	RuvX
PYH3_k127_6713840_1	255470.cbdbA68	3.345e-150	484.0	COG0343@1|root,COG0343@2|Bacteria,2G5RE@200795|Chloroflexi,34D2Q@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
PYH3_k127_6713840_5	639282.DEFDS_1829	9.085e-90	306.0	COG2070@1|root,COG2070@2|Bacteria,2GF0W@200930|Deferribacteres	200930|Deferribacteres	C	IMP dehydrogenase / GMP reductase domain	-	-	1.13.12.16	ko:K00459	ko00910,map00910	-	R00025	RC02541,RC02759	ko00000,ko00001,ko01000	-	-	-	NMO
PYH3_k127_6713840_7	1202962.KB907184_gene242	7.261e-80	280.0	COG2070@1|root,COG2070@2|Bacteria,1MWPC@1224|Proteobacteria,1RRA4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	COG2070 Dioxygenases related to 2-nitropropane dioxygenase	-	-	1.13.12.16,1.3.1.9	ko:K00459,ko:K02371	ko00061,ko00910,ko01100,ko01212,map00061,map00910,map01100,map01212	M00083	R00025,R04429,R04724,R04955,R04958,R04961,R04966,R04969,R07765	RC00052,RC00076,RC02541,RC02759	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	NMO
PYH3_k127_6713840_3	639282.DEFDS_1829	7.768e-104	346.0	COG2070@1|root,COG2070@2|Bacteria,2GF0W@200930|Deferribacteres	200930|Deferribacteres	C	IMP dehydrogenase / GMP reductase domain	-	-	1.13.12.16	ko:K00459	ko00910,map00910	-	R00025	RC02541,RC02759	ko00000,ko00001,ko01000	-	-	-	NMO
PYH3_k127_6713840_11	665571.STHERM_c14570	6.047e-38	146.0	COG0295@1|root,COG0295@2|Bacteria,2JB9Y@203691|Spirochaetes	203691|Spirochaetes	F	Cytidine and deoxycytidylate deaminase zinc-binding region	-	-	-	-	-	-	-	-	-	-	-	-	dCMP_cyt_deam_1
PYH3_k127_6713840_4	357808.RoseRS_3334	3.524e-91	310.0	COG0324@1|root,COG0324@2|Bacteria,2G5S7@200795|Chloroflexi,374TE@32061|Chloroflexia	32061|Chloroflexia	J	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
PYH3_k127_6713840_9	399549.Msed_2001	1.046e-42	166.0	COG1250@1|root,arCOG00249@2157|Archaea,2XPQ7@28889|Crenarchaeota	28889|Crenarchaeota	I	3-hydroxyacyl-CoA dehydrogenase	-	GO:0003674,GO:0003824,GO:0016829,GO:0016835,GO:0016836,GO:0043956	1.1.1.157,1.1.1.35,4.2.1.116,4.2.1.17	ko:K00074,ko:K15016,ko:K15019	ko00360,ko00362,ko00650,ko00720,ko01100,ko01120,ko01200,map00360,map00362,map00650,map00720,map01100,map01120,map01200	M00374,M00375	R01975,R01976,R03026,R03045,R05576,R06941	RC00029,RC00117,RC00831,RC00834	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
PYH3_k127_6713840_8	266117.Rxyl_2864	4.381e-73	251.0	COG0225@1|root,COG0225@2|Bacteria,2GJ1S@201174|Actinobacteria,4CQJ5@84995|Rubrobacteria	84995|Rubrobacteria	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
PYH3_k127_6713840_6	243164.DET0742	1.521e-82	282.0	COG0149@1|root,COG0149@2|Bacteria,2G69W@200795|Chloroflexi,34CU5@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	-	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
PYH3_k127_6713840_2	986075.CathTA2_1446	2.261e-116	386.0	COG1804@1|root,COG1804@2|Bacteria,1TP54@1239|Firmicutes,4HC4S@91061|Bacilli	91061|Bacilli	C	carnitine dehydratase	amacr	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
PYH3_k127_6713840_10	439235.Dalk_1142	6.266e-40	159.0	COG1042@1|root,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,42KZW@68525|delta/epsilon subdivisions,2WIQB@28221|Deltaproteobacteria,2MIWX@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM CoA-binding domain protein	-	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
PYH3_k127_6829245_6	909663.KI867149_gene3397	2.201e-30	124.0	COG4274@1|root,COG4274@2|Bacteria,1PUJQ@1224|Proteobacteria,42XN6@68525|delta/epsilon subdivisions,2WTHH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	GYD domain	-	-	-	-	-	-	-	-	-	-	-	-	GYD
PYH3_k127_6829245_0	909663.KI867150_gene1278	1.245e-216	683.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42M5F@68525|delta/epsilon subdivisions,2WJN6@28221|Deltaproteobacteria,2MQ5G@213462|Syntrophobacterales	28221|Deltaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
PYH3_k127_6829245_3	1499967.BAYZ01000080_gene956	2.111e-68	238.0	COG5012@1|root,COG5012@2|Bacteria,2NQTJ@2323|unclassified Bacteria	2|Bacteria	S	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,B12-binding_2
PYH3_k127_6829245_7	1038866.KB902824_gene1286	5.994e-10	70.0	28HWH@1|root,2Z82E@2|Bacteria,1MUF7@1224|Proteobacteria,2TV8Z@28211|Alphaproteobacteria,3JV6A@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_6829245_2	935948.KE386494_gene911	2.003e-135	441.0	COG1453@1|root,COG1453@2|Bacteria,1TQ5N@1239|Firmicutes,247SD@186801|Clostridia,42ENG@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM aldo keto reductase	-	-	-	ko:K07079	-	-	-	-	ko00000	-	-	-	Aldo_ket_red,Fer4_17
PYH3_k127_6829245_4	588581.Cpap_4241	1.32e-40	157.0	COG1853@1|root,COG1853@2|Bacteria,1V1EA@1239|Firmicutes,24FWS@186801|Clostridia,3WIF0@541000|Ruminococcaceae	186801|Clostridia	S	Flavin reductase-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
PYH3_k127_6829245_1	266117.Rxyl_1235	4.314e-141	461.0	COG3119@1|root,COG3119@2|Bacteria,2H50Z@201174|Actinobacteria,4CRT6@84995|Rubrobacteria	84995|Rubrobacteria	P	PFAM sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
PYH3_k127_6829245_5	373903.Hore_12950	5.849e-40	160.0	COG0407@1|root,COG0407@2|Bacteria,1V7NA@1239|Firmicutes,24MGR@186801|Clostridia	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
PYH3_k127_6874173_9	477974.Daud_2210	2.06e-22	97.0	COG2509@1|root,COG2509@2|Bacteria,1TP9I@1239|Firmicutes,247QM@186801|Clostridia,2613P@186807|Peptococcaceae	186801|Clostridia	S	FAD-dependent	-	-	-	ko:K07137	-	-	-	-	ko00000	-	-	-	FAD_binding_2,HI0933_like,Pyr_redox_2,Thi4
PYH3_k127_6874173_4	56780.SYN_02086	6.283e-94	327.0	COG1866@1|root,COG1866@2|Bacteria	2|Bacteria	H	phosphoenolpyruvate carboxykinase (ATP) activity	pckA	-	4.1.1.49	ko:K01610	ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00170	R00341	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_ATP
PYH3_k127_6874173_7	243231.GSU0774	1.384e-76	266.0	COG1600@1|root,COG1600@2|Bacteria,1RAYI@1224|Proteobacteria,42R4W@68525|delta/epsilon subdivisions,2WK0B@28221|Deltaproteobacteria,43S8Y@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_6874173_10	1322246.BN4_10873	3.647e-16	83.0	COG0599@1|root,COG0599@2|Bacteria,1PZQH@1224|Proteobacteria,42XZK@68525|delta/epsilon subdivisions,2WT47@28221|Deltaproteobacteria,2MCT8@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Carboxymuconolactone decarboxylase family	-	-	-	-	-	-	-	-	-	-	-	-	CMD
PYH3_k127_6874173_8	338969.Rfer_0357	1.525e-44	171.0	COG4275@1|root,COG4275@2|Bacteria,1MYDE@1224|Proteobacteria,2VQ0S@28216|Betaproteobacteria,4ABCM@80864|Comamonadaceae	28216|Betaproteobacteria	P	Chromate resistance exported protein	-	-	-	-	-	-	-	-	-	-	-	-	Chrome_Resist
PYH3_k127_6874173_5	521011.Mpal_2757	3.987e-82	287.0	COG0477@1|root,arCOG00130@2157|Archaea,2XX8J@28890|Euryarchaeota,2NB8J@224756|Methanomicrobia	224756|Methanomicrobia	G	Major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like
PYH3_k127_6874173_6	565033.GACE_0133	4.017e-81	287.0	COG1042@1|root,arCOG01338@2157|Archaea,arCOG01340@2157|Archaea,2XT9G@28890|Euryarchaeota,246RE@183980|Archaeoglobi	183980|Archaeoglobi	C	acetyl coenzyme A synthetase	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
PYH3_k127_6874173_2	311424.DhcVS_835	3.781e-114	381.0	COG0621@1|root,COG0621@2|Bacteria,2G5UI@200795|Chloroflexi,34D8Z@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Uncharacterized protein family UPF0004	-	-	2.8.4.5	ko:K18707	-	-	R10649	RC00003,RC03221	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,UPF0004
PYH3_k127_6874173_0	255470.cbdbA921	3.206e-170	544.0	COG0304@1|root,COG0304@2|Bacteria,2G5K7@200795|Chloroflexi,34CMH@301297|Dehalococcoidia	301297|Dehalococcoidia	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
PYH3_k127_6874173_1	243164.DET0964	6.896e-166	539.0	COG0608@1|root,COG0608@2|Bacteria,2G5US@200795|Chloroflexi,34CNY@301297|Dehalococcoidia	301297|Dehalococcoidia	L	DHH family	recJ	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
PYH3_k127_6874173_3	643648.Slip_2184	3.723e-108	365.0	COG1249@1|root,COG1249@2|Bacteria,1TP1W@1239|Firmicutes,249R3@186801|Clostridia,42JRZ@68298|Syntrophomonadaceae	186801|Clostridia	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	lpdA	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
PYH3_k127_6887016_4	997346.HMPREF9374_0896	2.719e-43	170.0	COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,4HAA6@91061|Bacilli,27BBK@186824|Thermoactinomycetaceae	91061|Bacilli	IQ	KR domain	fabG	GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	iYO844.BSU15910	adh_short_C2
PYH3_k127_6887016_1	224325.AF_0130	4.422e-57	213.0	COG0123@1|root,arCOG00324@2157|Archaea,2XT0B@28890|Euryarchaeota,246V5@183980|Archaeoglobi	183980|Archaeoglobi	BQ	PFAM histone deacetylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
PYH3_k127_6887016_5	666684.AfiDRAFT_1991	3.422e-23	102.0	2DP7H@1|root,330V6@2|Bacteria,1R3EB@1224|Proteobacteria,2U01I@28211|Alphaproteobacteria,3JYRG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Conserved hypothetical protein (Lin0512_fam)	MA20_27785	-	-	-	-	-	-	-	-	-	-	-	Lin0512_fam
PYH3_k127_6887016_2	644282.Deba_2980	3.746e-52	194.0	COG0508@1|root,COG0508@2|Bacteria,1MUJD@1224|Proteobacteria,42N18@68525|delta/epsilon subdivisions,2WJSK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2)	sucB	-	2.3.1.12,2.3.1.61	ko:K00627,ko:K00658	ko00010,ko00020,ko00310,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00310,map00620,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032,M00307	R00209,R02569,R02570,R02571,R08549	RC00004,RC02727,RC02742,RC02833,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2766	2-oxoacid_dh,Biotin_lipoyl,E3_binding
PYH3_k127_6887016_7	485913.Krac_0963	6.646e-09	60.0	COG0508@1|root,COG0508@2|Bacteria,2G7SG@200795|Chloroflexi	200795|Chloroflexi	C	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2)	-	-	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
PYH3_k127_6887016_0	1449126.JQKL01000003_gene1819	2.567e-78	273.0	COG0022@1|root,COG0022@2|Bacteria,1TP3J@1239|Firmicutes,249UD@186801|Clostridia,26AI0@186813|unclassified Clostridiales	186801|Clostridia	C	Transketolase, pyrimidine binding domain	-	-	-	ko:K21417	-	-	-	-	ko00000,ko01000	-	-	-	Transket_pyr,Transketolase_C
PYH3_k127_6887016_3	697303.Thewi_1630	4.899e-50	190.0	COG1071@1|root,COG1071@2|Bacteria,1TQDG@1239|Firmicutes,249HX@186801|Clostridia,42ENM@68295|Thermoanaerobacterales	186801|Clostridia	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	acoA	-	1.2.4.1	ko:K00161,ko:K21416	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
PYH3_k127_6887016_6	479431.Namu_1092	3.934e-22	100.0	COG1063@1|root,COG1063@2|Bacteria,2GKC7@201174|Actinobacteria,4ESIS@85013|Frankiales	201174|Actinobacteria	E	Alcohol dehydrogenase GroES domain protein	-	-	1.1.1.303,1.1.1.4	ko:K00004	ko00650,map00650	-	R02855,R02946,R10504	RC00205,RC00525	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
PYH3_k127_6957974_0	1206743.BAGM01000199_gene975	4.775e-138	455.0	COG2272@1|root,COG2272@2|Bacteria,2GJCN@201174|Actinobacteria,4G5Z2@85025|Nocardiaceae	201174|Actinobacteria	I	Carboxylesterase family	-	-	-	ko:K03929	-	-	-	-	ko00000,ko01000	-	CE10	-	COesterase
PYH3_k127_6966483_4	1382356.JQMP01000003_gene2358	1.632e-13	70.0	COG0420@1|root,COG0420@2|Bacteria,2G60M@200795|Chloroflexi,27XMN@189775|Thermomicrobia	189775|Thermomicrobia	L	SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity	sbcD	-	-	ko:K03547	-	-	-	-	ko00000,ko03400	-	-	-	Metallophos
PYH3_k127_6966483_0	311424.DhcVS_693	4.971e-204	643.0	COG0423@1|root,COG0423@2|Bacteria,2G62M@200795|Chloroflexi,34D2R@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Catalyzes the attachment of glycine to tRNA(Gly)	glyS	-	6.1.1.14	ko:K01880	ko00970,map00970	M00359,M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	HGTP_anticodon,tRNA-synt_2b
PYH3_k127_6966483_3	243164.DET0786	4.521e-24	109.0	2A4C2@1|root,30SXR@2|Bacteria,2GAST@200795|Chloroflexi,34D9P@301297|Dehalococcoidia	301297|Dehalococcoidia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_6966483_1	243164.DET1193	3.8e-64	225.0	COG0461@1|root,COG0461@2|Bacteria,2G6RG@200795|Chloroflexi,34CZB@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
PYH3_k127_6966483_2	644966.Tmar_0963	1.86e-24	106.0	COG0681@1|root,COG0681@2|Bacteria,1V7H9@1239|Firmicutes,24HHW@186801|Clostridia,3WDTC@538999|Clostridiales incertae sedis	186801|Clostridia	U	TIGRFAM signal peptidase I, bacterial type	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
PYH3_k127_6983857_5	696369.KI912183_gene1136	7.663e-43	165.0	COG1150@1|root,COG1150@2|Bacteria,1V6M0@1239|Firmicutes,24M4D@186801|Clostridia,26709@186807|Peptococcaceae	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03390,ko:K16887	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_17,Fer4_8
PYH3_k127_6983857_3	868595.Desca_0819	1.37e-85	296.0	COG1150@1|root,COG1150@2|Bacteria	2|Bacteria	C	4Fe-4S dicluster domain	-	-	1.17.1.9	ko:K00125,ko:K03646	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000,ko02000	2.C.1.2	-	-	Fer4,Fer4_17,Fer4_8,FrhB_FdhB_C
PYH3_k127_6983857_4	1125863.JAFN01000001_gene1777	8.022e-58	203.0	COG1908@1|root,COG1908@2|Bacteria,1RCZY@1224|Proteobacteria,42TFE@68525|delta/epsilon subdivisions,2WPDR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM methyl-viologen-reducing hydrogenase delta subunit	-	-	-	-	-	-	-	-	-	-	-	-	FlpD
PYH3_k127_6983857_0	1121423.JONT01000008_gene701	2.614e-260	834.0	COG1148@1|root,COG1148@2|Bacteria,1V5YJ@1239|Firmicutes	1239|Firmicutes	C	binding domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Fer4_7,Pyr_redox_2
PYH3_k127_6983857_1	690850.Desaf_1866	3.775e-234	741.0	COG1148@1|root,COG1148@2|Bacteria,1QUMN@1224|Proteobacteria,43BMA@68525|delta/epsilon subdivisions,2X6ZG@28221|Deltaproteobacteria,2M898@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,FlpD,Pyr_redox_2
PYH3_k127_6983857_2	177437.HRM2_22720	3.193e-151	491.0	COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1MU2H@1224|Proteobacteria,42M6X@68525|delta/epsilon subdivisions,2X6YD@28221|Deltaproteobacteria,2MIN8@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_20,Pyr_redox_2
PYH3_k127_701190_0	264732.Moth_1314	6.18e-103	344.0	COG0407@1|root,COG0407@2|Bacteria,1TRJG@1239|Firmicutes,24B34@186801|Clostridia,42G9W@68295|Thermoanaerobacterales	186801|Clostridia	H	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
PYH3_k127_701190_1	710696.Intca_3418	5.053e-55	197.0	COG4412@1|root,COG4412@2|Bacteria,2GMKQ@201174|Actinobacteria,4FG03@85021|Intrasporangiaceae	201174|Actinobacteria	S	Immune inhibitor A peptidase M6	-	-	-	ko:K09607	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M6
PYH3_k127_7036822_3	552811.Dehly_0817	7.986e-139	444.0	COG1614@1|root,COG1614@2|Bacteria,2GAQT@200795|Chloroflexi,34D3V@301297|Dehalococcoidia	301297|Dehalococcoidia	C	CO dehydrogenase/acetyl-CoA synthase complex beta subunit	-	-	2.3.1.169	ko:K14138	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00377	R08433,R10243	RC00004,RC00113,RC01144,RC02963,RC02964,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhC
PYH3_k127_7036822_2	589865.DaAHT2_0824	2.115e-168	539.0	COG1456@1|root,COG1456@2|Bacteria,1R4RE@1224|Proteobacteria,42M89@68525|delta/epsilon subdivisions,2WJVQ@28221|Deltaproteobacteria,2MI7W@213118|Desulfobacterales	28221|Deltaproteobacteria	C	CO dehydrogenase acetyl-CoA synthase delta subunit	-	-	2.1.1.245	ko:K00197	ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200	M00357,M00377,M00422	R09096,R10219,R10243	RC00004,RC00113,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhD,FeS
PYH3_k127_7036822_4	1123371.ATXH01000023_gene935	4.495e-100	334.0	COG1410@1|root,COG1410@2|Bacteria,2GH4X@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	E	Pterin binding enzyme	-	-	2.1.1.258	ko:K15023	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00377	R02289,R10243	RC00004,RC00113,RC01144,RC02871,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
PYH3_k127_7036822_11	1089553.Tph_c14980	4.969e-33	136.0	COG1456@1|root,COG1456@2|Bacteria,1UIEM@1239|Firmicutes,25EJY@186801|Clostridia,42GZB@68295|Thermoanaerobacterales	186801|Clostridia	C	Domain of unknown function (DUF3786)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3786
PYH3_k127_7036822_10	552811.Dehly_0414	1.099e-43	168.0	COG0746@1|root,COG0746@2|Bacteria,2G786@200795|Chloroflexi,34D1K@301297|Dehalococcoidia	301297|Dehalococcoidia	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	mobA	-	2.7.7.77	ko:K03752	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3,NTPase_1
PYH3_k127_7036822_6	1121430.JMLG01000013_gene1885	3.217e-81	277.0	COG3383@1|root,COG3383@2|Bacteria,1V1Y2@1239|Firmicutes,24FSX@186801|Clostridia,263ZV@186807|Peptococcaceae	186801|Clostridia	C	NADH ubiquinone oxidoreductase, subunit G, iron-sulphur binding	-	-	1.17.1.9,1.6.5.3	ko:K00123,ko:K00336	ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200	M00144	R00519,R11945	RC00061,RC02796	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Fer4,Fer4_21,NADH-G_4Fe-4S_3
PYH3_k127_7036822_0	760568.Desku_3135	2.269e-282	879.0	COG1894@1|root,COG1894@2|Bacteria,1TQB0@1239|Firmicutes,24D58@186801|Clostridia,2618B@186807|Peptococcaceae	186801|Clostridia	C	NADH ubiquinone oxidoreductase, F subunit, iron sulphur binding	-	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
PYH3_k127_7036822_8	760568.Desku_3136	7.237e-55	197.0	COG1905@1|root,COG1905@2|Bacteria,1V4BY@1239|Firmicutes,24HER@186801|Clostridia,261T0@186807|Peptococcaceae	186801|Clostridia	C	Thioredoxin-like [2Fe-2S] ferredoxin	-	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
PYH3_k127_7036822_7	311424.DhcVS_47	3.869e-61	223.0	COG1466@1|root,COG1466@2|Bacteria,2G6XX@200795|Chloroflexi,34D0N@301297|Dehalococcoidia	301297|Dehalococcoidia	L	DNA polymerase III, delta subunit	holA	-	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta
PYH3_k127_7036822_1	273068.TTE2385	5.413e-194	618.0	COG4799@1|root,COG4799@2|Bacteria,1TQCV@1239|Firmicutes,247WG@186801|Clostridia,42ESJ@68295|Thermoanaerobacterales	186801|Clostridia	I	PFAM carboxyl transferase	pccB	-	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
PYH3_k127_7036822_12	243164.DET0617	3.688e-31	124.0	2A4E8@1|root,30T02@2|Bacteria,2GAVS@200795|Chloroflexi,34DG0@301297|Dehalococcoidia	301297|Dehalococcoidia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_7036822_13	411461.DORFOR_01196	1.114e-29	124.0	COG0526@1|root,COG0526@2|Bacteria,1VAPY@1239|Firmicutes,25B5Z@186801|Clostridia	186801|Clostridia	CO	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,DsbD,Redoxin
PYH3_k127_7036822_9	255470.cbdbA601	1.847e-48	181.0	COG0785@1|root,COG0785@2|Bacteria,2G6V3@200795|Chloroflexi,34CW2@301297|Dehalococcoidia	301297|Dehalococcoidia	O	Cytochrome C biogenesis protein transmembrane region	ccdA	-	-	ko:K06196	-	-	-	-	ko00000,ko02000	5.A.1.2	-	-	DsbD
PYH3_k127_7036822_15	243164.DET1448	1.17e-19	88.0	29WVC@1|root,30IH0@2|Bacteria,2G9KW@200795|Chloroflexi,34DPM@301297|Dehalococcoidia	301297|Dehalococcoidia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_7036822_5	913865.DOT_1455	8.257e-92	315.0	COG1960@1|root,COG1960@2|Bacteria,1TP57@1239|Firmicutes,247UB@186801|Clostridia,260KZ@186807|Peptococcaceae	186801|Clostridia	I	PFAM Acyl-CoA dehydrogenase, C-terminal domain	bcd2	-	1.3.8.1	ko:K00248	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212	-	R01175,R01178,R02661,R03172,R04751	RC00052,RC00068,RC00076,RC00120,RC00148	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,ETF_alpha,Rubredoxin
PYH3_k127_7036822_14	357808.RoseRS_2336	6.154e-22	98.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
PYH3_k127_7179381_7	43989.cce_1701	7.439e-05	46.0	COG4633@1|root,COG4633@2|Bacteria,1G713@1117|Cyanobacteria,3KIBH@43988|Cyanothece	1117|Cyanobacteria	S	Cupredoxin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1
PYH3_k127_7179381_5	1506994.JNLQ01000002_gene1193	1.546e-14	79.0	2E9Z8@1|root,3344Q@2|Bacteria,1VEY3@1239|Firmicutes,25AE8@186801|Clostridia,4C1F5@830|Butyrivibrio	186801|Clostridia	S	Domain of unknown function (DUF4418)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4418
PYH3_k127_7179381_2	292459.STH855	1.045e-58	221.0	COG0577@1|root,COG0577@2|Bacteria,1UYZ9@1239|Firmicutes,2484S@186801|Clostridia	186801|Clostridia	V	Efflux ABC transporter, permease protein	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
PYH3_k127_7179381_1	545264.KB898744_gene1971	5.363e-60	215.0	COG1136@1|root,COG1136@2|Bacteria,1MVSQ@1224|Proteobacteria,1RMWK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	Part of the ABC transporter complex LolCDE involved in the translocation of	-	-	-	ko:K09810	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.125	-	-	ABC_tran
PYH3_k127_7179381_4	243164.DET1461	1.063e-15	89.0	COG5513@1|root,COG5513@2|Bacteria,2GAUF@200795|Chloroflexi,34DDI@301297|Dehalococcoidia	301297|Dehalococcoidia	M	Chagasin family peptidase inhibitor I42	-	-	-	ko:K14475	ko05143,map05143	-	-	-	ko00000,ko00001	-	-	-	Inhibitor_I42
PYH3_k127_7179381_0	926550.CLDAP_21020	5.993e-69	240.0	COG2197@1|root,COG2197@2|Bacteria,2G8EU@200795|Chloroflexi	200795|Chloroflexi	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
PYH3_k127_7179381_6	1120949.KB903317_gene1681	4.073e-05	54.0	COG3371@1|root,COG3371@2|Bacteria,2IMS7@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF998)	-	-	-	-	-	-	-	-	-	-	-	-	DUF998
PYH3_k127_7179381_3	1280952.HJA_16864	1.489e-29	125.0	COG2070@1|root,COG2070@2|Bacteria,1MWPC@1224|Proteobacteria,2TQRT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	2-nitropropane dioxygenase	-	-	1.13.12.16	ko:K00459	ko00910,map00910	-	R00025	RC02541,RC02759	ko00000,ko00001,ko01000	-	-	-	NMO
PYH3_k127_7305497_3	552811.Dehly_0670	2.562e-35	138.0	COG1285@1|root,COG1285@2|Bacteria,2G77U@200795|Chloroflexi,34DBR@301297|Dehalococcoidia	301297|Dehalococcoidia	S	MgtC family	-	-	-	ko:K07507	-	-	-	-	ko00000,ko02000	9.B.20	-	-	MgtC
PYH3_k127_7305497_0	255470.cbdbA806	2.826e-195	616.0	COG0065@1|root,COG0065@2|Bacteria,2G5IZ@200795|Chloroflexi,34D4T@301297|Dehalococcoidia	301297|Dehalococcoidia	H	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
PYH3_k127_7305497_4	1123248.KB893386_gene1937	3.564e-21	94.0	COG3695@1|root,COG3695@2|Bacteria,4NZHS@976|Bacteroidetes,1IZ68@117747|Sphingobacteriia	976|Bacteroidetes	L	6-O-methylguanine DNA methyltransferase, DNA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DNA_binding_1
PYH3_k127_7305497_5	497964.CfE428DRAFT_0998	1.528e-19	90.0	COG0350@1|root,COG0350@2|Bacteria	2|Bacteria	L	methylated-DNA-[protein]-cysteine S-methyltransferase activity	ogt	-	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1,Methyltransf_1N
PYH3_k127_7305497_6	983544.Lacal_2338	3.748e-15	76.0	COG2827@1|root,COG2827@2|Bacteria,4NUYX@976|Bacteroidetes,1I4M9@117743|Flavobacteriia	976|Bacteroidetes	L	GIY-YIG catalytic domain	-	-	-	ko:K07461	-	-	-	-	ko00000	-	-	-	GIY-YIG
PYH3_k127_7305497_7	163908.KB235896_gene2538	3.867e-11	63.0	COG2827@1|root,COG2827@2|Bacteria,1GK2X@1117|Cyanobacteria,1HT5P@1161|Nostocales	1117|Cyanobacteria	L	GIY-YIG catalytic domain	-	-	-	ko:K07461	-	-	-	-	ko00000	-	-	-	GIY-YIG
PYH3_k127_7305497_1	243164.DET0827	1.982e-74	254.0	COG0066@1|root,COG0066@2|Bacteria,2G6PB@200795|Chloroflexi,34D4Q@301297|Dehalococcoidia	301297|Dehalococcoidia	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
PYH3_k127_7305497_2	243164.DET0826	3.2e-71	244.0	COG0473@1|root,COG0473@2|Bacteria,2G63C@200795|Chloroflexi,34CP7@301297|Dehalococcoidia	301297|Dehalococcoidia	CE	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
PYH3_k127_7370064_4	593117.TGAM_0072	1.729e-48	188.0	COG1063@1|root,arCOG01459@2157|Archaea,2XT8W@28890|Euryarchaeota,2438B@183968|Thermococci	183968|Thermococci	E	Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
PYH3_k127_7370064_1	247490.KSU1_C0048	7.336e-80	284.0	COG2211@1|root,COG2211@2|Bacteria,2IY9C@203682|Planctomycetes	203682|Planctomycetes	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
PYH3_k127_7370064_0	767817.Desgi_3217	1.506e-84	290.0	COG4221@1|root,COG4221@2|Bacteria,1UIB4@1239|Firmicutes,25EG6@186801|Clostridia,265GT@186807|Peptococcaceae	186801|Clostridia	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
PYH3_k127_7370064_3	1122137.AQXF01000001_gene2828	1.722e-76	273.0	COG1680@1|root,COG1680@2|Bacteria,1MVPR@1224|Proteobacteria,2TRWZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
PYH3_k127_7370064_5	1449347.JQLN01000006_gene2761	2.228e-44	168.0	COG3896@1|root,COG3896@2|Bacteria,2IFF0@201174|Actinobacteria,2M33F@2063|Kitasatospora	201174|Actinobacteria	V	Chloramphenicol phosphotransferase-like protein	-	-	-	ko:K18554	-	-	-	-	br01600,ko00000,ko01000,ko01504	-	-	-	CPT
PYH3_k127_7370064_2	293826.Amet_1499	3.903e-78	280.0	COG3039@1|root,COG3039@2|Bacteria,1TPFS@1239|Firmicutes,249JM@186801|Clostridia,36E38@31979|Clostridiaceae	1239|Firmicutes	L	This gene contains a nucleotide ambiguity which may be the result of a sequencing error	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
PYH3_k127_737254_22	768704.Desmer_1627	1.652e-08	56.0	COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,247PV@186801|Clostridia,260VS@186807|Peptococcaceae	186801|Clostridia	IQ	PFAM short chain dehydrogenase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short,adh_short_C2
PYH3_k127_737254_10	96561.Dole_2662	1.483e-76	264.0	COG1028@1|root,COG1028@2|Bacteria,1MWB6@1224|Proteobacteria,42S4A@68525|delta/epsilon subdivisions,2WNE7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	IQ	PFAM Short-chain dehydrogenase reductase SDR	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
PYH3_k127_737254_11	96561.Dole_2662	5.749e-71	248.0	COG1028@1|root,COG1028@2|Bacteria,1MWB6@1224|Proteobacteria,42S4A@68525|delta/epsilon subdivisions,2WNE7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	IQ	PFAM Short-chain dehydrogenase reductase SDR	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
PYH3_k127_737254_1	479434.Sthe_0907	7.964e-145	473.0	COG0154@1|root,COG0154@2|Bacteria,2G7WJ@200795|Chloroflexi,27XWA@189775|Thermomicrobia	189775|Thermomicrobia	J	Belongs to the amidase family	-	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
PYH3_k127_737254_14	1120973.AQXL01000104_gene2603	4.057e-58	210.0	COG0652@1|root,COG0652@2|Bacteria,1TRHW@1239|Firmicutes,4H9V0@91061|Bacilli,279GS@186823|Alicyclobacillaceae	91061|Bacilli	O	Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD	-	-	-	-	-	-	-	-	-	-	-	-	Pro_isomerase
PYH3_k127_737254_13	324602.Caur_2829	5.75e-62	217.0	COG0652@1|root,COG0652@2|Bacteria,2G69B@200795|Chloroflexi,375JG@32061|Chloroflexia	32061|Chloroflexia	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	-	-	5.2.1.8	ko:K03768	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Pro_isomerase
PYH3_k127_737254_12	552811.Dehly_0334	1.58e-69	247.0	COG5653@1|root,COG5653@2|Bacteria,2G6Z0@200795|Chloroflexi,34CZI@301297|Dehalococcoidia	301297|Dehalococcoidia	M	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_6
PYH3_k127_737254_6	311424.DhcVS_874	2.592e-107	361.0	COG0438@1|root,COG0438@2|Bacteria,2G5KS@200795|Chloroflexi,34CVY@301297|Dehalococcoidia	301297|Dehalococcoidia	M	Glycosyl transferase 4-like domain	-	-	2.4.1.250	ko:K15521	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_transf_4,Glycos_transf_1
PYH3_k127_737254_9	1125863.JAFN01000001_gene2314	3.217e-78	267.0	COG2120@1|root,COG2120@2|Bacteria,1MUTM@1224|Proteobacteria,42Q20@68525|delta/epsilon subdivisions,2WP8Q@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	GlcNAc-PI de-N-acetylase	-	-	-	ko:K01463	-	-	-	-	ko00000,ko01000	-	-	-	PIG-L
PYH3_k127_737254_17	525904.Tter_2687	7.55e-45	170.0	COG0491@1|root,COG0491@2|Bacteria,2NPD5@2323|unclassified Bacteria	2|Bacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
PYH3_k127_737254_7	335543.Sfum_0114	3.88e-105	351.0	COG1013@1|root,COG1013@2|Bacteria,1MUY9@1224|Proteobacteria,42MQY@68525|delta/epsilon subdivisions,2WJGJ@28221|Deltaproteobacteria,2MREB@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	PFAM thiamine pyrophosphate enzyme	-	-	1.2.7.1	ko:K00170	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
PYH3_k127_737254_2	335543.Sfum_0115	9.796e-131	429.0	COG0674@1|root,COG0674@2|Bacteria,1MVM0@1224|Proteobacteria,42MZ0@68525|delta/epsilon subdivisions,2WJG3@28221|Deltaproteobacteria,2MQT4@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	ferredoxin oxidoreductase alpha subunit	-	-	1.2.7.1	ko:K00169	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
PYH3_k127_737254_21	1121918.ARWE01000001_gene3074	2.66e-31	124.0	COG1144@1|root,COG1144@2|Bacteria,1NE6F@1224|Proteobacteria,42W4G@68525|delta/epsilon subdivisions,2WS1A@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	oxidoreductase, delta subunit	-	-	1.2.7.1	ko:K00171	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4
PYH3_k127_737254_16	335543.Sfum_0543	7.082e-47	177.0	COG1014@1|root,COG1014@2|Bacteria,1N0EJ@1224|Proteobacteria,42UN6@68525|delta/epsilon subdivisions,2WQCE@28221|Deltaproteobacteria,2MRW1@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	PFAM pyruvate ferredoxin flavodoxin oxidoreductase	-	-	1.2.7.1	ko:K00172	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
PYH3_k127_737254_5	243164.DET0846	5.543e-115	383.0	COG0124@1|root,COG0124@2|Bacteria,2G962@200795|Chloroflexi,34CX8@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine	hisZ	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_His
PYH3_k127_737254_0	243164.DET0845	3.002e-158	512.0	COG0040@1|root,COG0040@2|Bacteria,2G6DD@200795|Chloroflexi,34CWY@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity	-	-	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG
PYH3_k127_737254_3	255470.cbdbA826	2.344e-127	422.0	COG0141@1|root,COG0141@2|Bacteria,2G5KP@200795|Chloroflexi,34D1N@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	-	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
PYH3_k127_737254_4	255470.cbdbA825	1.23e-119	394.0	COG0079@1|root,COG0079@2|Bacteria,2G5U4@200795|Chloroflexi,34CIS@301297|Dehalococcoidia	301297|Dehalococcoidia	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
PYH3_k127_737254_8	255470.cbdbA824	3.041e-78	265.0	COG0131@1|root,COG0131@2|Bacteria,2G6JA@200795|Chloroflexi,34D1H@301297|Dehalococcoidia	301297|Dehalococcoidia	E	imidazoleglycerol-phosphate dehydratase activity	hisB	-	4.2.1.19	ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03457	RC00932	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPD
PYH3_k127_737254_19	1321778.HMPREF1982_02334	1.005e-38	148.0	COG0221@1|root,COG0221@2|Bacteria,1V8EF@1239|Firmicutes,24JN0@186801|Clostridia	186801|Clostridia	C	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions	-	-	3.6.1.1	ko:K01507	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	-
PYH3_k127_737254_18	479434.Sthe_2387	2.862e-39	151.0	COG1051@1|root,COG1051@2|Bacteria,2G7FI@200795|Chloroflexi	200795|Chloroflexi	F	PFAM NUDIX hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
PYH3_k127_737254_15	1123376.AUIU01000017_gene180	8.276e-58	210.0	COG3640@1|root,COG3640@2|Bacteria	2|Bacteria	D	PFAM CobQ CobB MinD ParA nucleotide binding domain	-	-	-	ko:K07321	-	-	-	-	ko00000	-	-	-	CbiA
PYH3_k127_737254_20	134676.ACPL_7355	5.574e-36	146.0	COG2365@1|root,COG2365@2|Bacteria,2GK28@201174|Actinobacteria,4DCR5@85008|Micromonosporales	201174|Actinobacteria	T	Tyrosine phosphatase family	-	-	3.1.3.48	ko:K01104	-	-	-	-	ko00000,ko01000	-	-	-	Y_phosphatase3
PYH3_k127_7385811_1	439235.Dalk_3101	5.709e-129	424.0	COG0683@1|root,COG0683@2|Bacteria,1MXPJ@1224|Proteobacteria,42UB1@68525|delta/epsilon subdivisions,2WQ1B@28221|Deltaproteobacteria,2MNNK@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Periplasmic binding protein domain	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
PYH3_k127_7385811_3	986075.CathTA2_1530	4.704e-92	310.0	COG0559@1|root,COG0559@2|Bacteria	2|Bacteria	E	leucine import across plasma membrane	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
PYH3_k127_7385811_2	439235.Dalk_3103	4.5e-125	409.0	COG4177@1|root,COG4177@2|Bacteria,1MU52@1224|Proteobacteria,42RI3@68525|delta/epsilon subdivisions,2WNVC@28221|Deltaproteobacteria,2MJX3@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
PYH3_k127_7385811_0	255470.cbdbA339	4.384e-233	737.0	COG0465@1|root,COG0465@2|Bacteria,2G5J3@200795|Chloroflexi,34CIN@301297|Dehalococcoidia	301297|Dehalococcoidia	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
PYH3_k127_7385811_5	101510.RHA1_ro11036	4.918e-80	275.0	COG1028@1|root,COG1028@2|Bacteria,2GIRG@201174|Actinobacteria,4FU04@85025|Nocardiaceae	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
PYH3_k127_7385811_9	311424.DhcVS_18	2.062e-48	180.0	COG1490@1|root,COG1490@2|Bacteria,2G6P5@200795|Chloroflexi,34DAV@301297|Dehalococcoidia	301297|Dehalococcoidia	J	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality	dtd	-	-	ko:K07560	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Tyr_Deacylase
PYH3_k127_7385811_6	580327.Tthe_1658	9.284e-79	274.0	COG2025@1|root,COG2025@2|Bacteria,1TPC8@1239|Firmicutes,247NF@186801|Clostridia,42FKR@68295|Thermoanaerobacterales	186801|Clostridia	C	electron transfer flavoprotein, alpha subunit	etfA	-	1.3.1.108	ko:K03522,ko:K22432	-	-	-	-	ko00000,ko01000,ko04147	-	-	-	ETF,ETF_alpha
PYH3_k127_7385811_7	552811.Dehly_0968	8.74e-77	265.0	COG2086@1|root,COG2086@2|Bacteria,2G72U@200795|Chloroflexi	200795|Chloroflexi	C	electron transfer flavoprotein	-	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
PYH3_k127_7385811_8	545695.TREAZ_3182	8.491e-63	224.0	COG2227@1|root,COG2227@2|Bacteria,2J59U@203691|Spirochaetes	203691|Spirochaetes	H	Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
PYH3_k127_7385811_4	246196.MSMEI_2158	1.075e-89	309.0	COG1804@1|root,COG1804@2|Bacteria,2GIU7@201174|Actinobacteria,233VQ@1762|Mycobacteriaceae	201174|Actinobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
PYH3_k127_7385811_10	255470.cbdbA1128	6.438e-40	154.0	COG2890@1|root,COG2890@2|Bacteria,2G6I8@200795|Chloroflexi,34CQQ@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS,Methyltransf_31
PYH3_k127_7386068_10	1117108.PAALTS15_02392	3.603e-42	160.0	COG1136@1|root,COG1136@2|Bacteria,1TPNI@1239|Firmicutes,4HC9Y@91061|Bacilli,26SN3@186822|Paenibacillaceae	91061|Bacilli	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
PYH3_k127_7386068_3	1304880.JAGB01000002_gene1928	1.989e-92	312.0	COG1136@1|root,COG1136@2|Bacteria,1TP6H@1239|Firmicutes,247JJ@186801|Clostridia	186801|Clostridia	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
PYH3_k127_7386068_7	357808.RoseRS_0178	1.967e-60	239.0	COG0577@1|root,COG0577@2|Bacteria,2G5WX@200795|Chloroflexi	200795|Chloroflexi	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
PYH3_k127_7386068_4	521045.Kole_0816	5.283e-75	257.0	COG0325@1|root,COG0325@2|Bacteria,2GCRN@200918|Thermotogae	200918|Thermotogae	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis	-	-	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
PYH3_k127_7386068_8	224325.AF_1190	3.041e-49	189.0	COG1250@1|root,arCOG00250@2157|Archaea,2XTMV@28890|Euryarchaeota	28890|Euryarchaeota	I	3-hydroxyacyl-CoA dehydrogenase	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
PYH3_k127_7386068_11	311424.DhcVS_43	1.565e-29	121.0	COG3824@1|root,COG3824@2|Bacteria,2G72E@200795|Chloroflexi,34DE1@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Zincin-like metallopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Zincin_1
PYH3_k127_7386068_6	255470.cbdbA530	2.564e-69	242.0	COG1259@1|root,COG1259@2|Bacteria,2G6P6@200795|Chloroflexi,34DAC@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Bifunctional nuclease	-	-	-	ko:K08999	-	-	-	-	ko00000	-	-	-	DNase-RNase
PYH3_k127_7386068_16	479434.Sthe_1243	2.929e-09	63.0	2A4SM@1|root,30TE1@2|Bacteria,2GA2B@200795|Chloroflexi,27YRH@189775|Thermomicrobia	189775|Thermomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_7386068_14	311424.DhcVS_496	1.454e-15	79.0	2BPKF@1|root,32IDF@2|Bacteria,2GAWX@200795|Chloroflexi,34DI2@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter	-	-	-	-	-	-	-	-	-	-	-	-	ATPase_gene1
PYH3_k127_7386068_5	552811.Dehly_0545	8.793e-75	263.0	COG0356@1|root,COG0356@2|Bacteria,2G6NF@200795|Chloroflexi,34D35@301297|Dehalococcoidia	301297|Dehalococcoidia	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
PYH3_k127_7386068_13	552811.Dehly_0546	2.508e-22	98.0	COG0636@1|root,COG0636@2|Bacteria,2G72D@200795|Chloroflexi,34DHU@301297|Dehalococcoidia	301297|Dehalococcoidia	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpE	-	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_C
PYH3_k127_7386068_9	255470.cbdbA534	2.358e-43	164.0	COG0711@1|root,COG0711@2|Bacteria,2G76T@200795|Chloroflexi,34CVK@301297|Dehalococcoidia	301297|Dehalococcoidia	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	atpF	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
PYH3_k127_7386068_12	525904.Tter_0066	7.069e-28	119.0	COG0712@1|root,COG0712@2|Bacteria,2NPV0@2323|unclassified Bacteria	2|Bacteria	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K02109,ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B,OSCP
PYH3_k127_7386068_0	311424.DhcVS_501	2.102e-241	754.0	COG0056@1|root,COG0056@2|Bacteria,2G5YQ@200795|Chloroflexi,34D4K@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
PYH3_k127_7386068_2	255470.cbdbA537	9.705e-118	385.0	COG0224@1|root,COG0224@2|Bacteria,2G69I@200795|Chloroflexi,34CV9@301297|Dehalococcoidia	301297|Dehalococcoidia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	-	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
PYH3_k127_7386068_1	552811.Dehly_0551	1.949e-237	740.0	COG0055@1|root,COG0055@2|Bacteria,2G5JI@200795|Chloroflexi,34D3I@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
PYH3_k127_7386068_17	311424.DhcVS_504	5.062e-08	56.0	COG0355@1|root,COG0355@2|Bacteria,2G70H@200795|Chloroflexi,34DAK@301297|Dehalococcoidia	301297|Dehalococcoidia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	-	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE,ATP-synt_DE_N
PYH3_k127_7396403_5	552811.Dehly_1056	2.386e-41	157.0	COG0182@1|root,COG0182@2|Bacteria,2G5Z3@200795|Chloroflexi,34CWH@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	mtnA	-	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	-	IF-2B
PYH3_k127_7396403_6	1232437.KL662026_gene969	4.553e-25	111.0	COG2020@1|root,COG2020@2|Bacteria,1RBJE@1224|Proteobacteria,42XPQ@68525|delta/epsilon subdivisions,2WT34@28221|Deltaproteobacteria,2MMDN@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Phospholipid methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
PYH3_k127_7396403_3	243164.DET0595	5.845e-57	205.0	COG0193@1|root,COG0193@2|Bacteria,2G6SW@200795|Chloroflexi,34CQN@301297|Dehalococcoidia	301297|Dehalococcoidia	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	-	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
PYH3_k127_7396403_0	255470.cbdbA577	5.132e-249	786.0	COG0272@1|root,COG0272@2|Bacteria,2G5TK@200795|Chloroflexi,34CJG@301297|Dehalococcoidia	301297|Dehalococcoidia	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
PYH3_k127_7396403_2	311424.DhcVS_537	5.089e-130	428.0	COG4198@1|root,COG4198@2|Bacteria,2G6FC@200795|Chloroflexi	200795|Chloroflexi	S	Protein of unknown function (DUF1015)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1015
PYH3_k127_7396403_4	1048834.TC41_0813	4.12e-47	181.0	COG1024@1|root,COG1024@2|Bacteria,1TQ2V@1239|Firmicutes,4HBT0@91061|Bacilli	91061|Bacilli	I	Belongs to the enoyl-CoA hydratase isomerase family	paaG	-	5.3.3.18	ko:K15866	ko00360,ko01120,map00360,map01120	-	R09837,R09839	RC00004,RC00326,RC02689,RC03003	ko00000,ko00001,ko01000	-	-	-	ECH_1
PYH3_k127_7396403_1	255470.cbdbA580	7.927e-218	687.0	COG0111@1|root,COG0111@2|Bacteria,2G67B@200795|Chloroflexi,34CNE@301297|Dehalococcoidia	301297|Dehalococcoidia	EH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	serA	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
PYH3_k127_7396403_7	927658.AJUM01000017_gene3097	0.0008668	42.0	COG0436@1|root,COG0436@2|Bacteria	2|Bacteria	E	Aminotransferase	bamJ	-	-	-	-	-	-	-	-	-	-	iSB619.SA_RS10050	Aminotran_1_2
PYH3_k127_7415767_9	243164.DET1347	2.181e-20	95.0	2EMMB@1|root,33F9Q@2|Bacteria,2G9IY@200795|Chloroflexi,34D9F@301297|Dehalococcoidia	301297|Dehalococcoidia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_7415767_4	552811.Dehly_1102	2.633e-53	194.0	COG1595@1|root,COG1595@2|Bacteria,2G6X7@200795|Chloroflexi,34D3G@301297|Dehalococcoidia	301297|Dehalococcoidia	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4
PYH3_k127_7415767_5	255470.cbdbA591	8.344e-44	168.0	COG0454@1|root,COG0456@2|Bacteria,2G6TF@200795|Chloroflexi,34CT0@301297|Dehalococcoidia	301297|Dehalococcoidia	K	FR47-like protein	rimI	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
PYH3_k127_7415767_10	351160.RCIX875	4.412e-16	79.0	arCOG02240@1|root,arCOG02240@2157|Archaea	2157|Archaea	S	4-oxalocrotonate tautomerase	-	-	5.3.2.6	ko:K01821	ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220	M00569	R03966,R05389	RC01040,RC01355	ko00000,ko00001,ko00002,ko01000	-	-	-	Tautomerase
PYH3_k127_7415767_11	552811.Dehly_0735	1.234e-13	73.0	2BQAQ@1|root,32J5P@2|Bacteria,2GAW4@200795|Chloroflexi,34DGJ@301297|Dehalococcoidia	301297|Dehalococcoidia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_7415767_3	255470.cbdbA594	1.293e-62	223.0	COG0500@1|root,COG2226@2|Bacteria,2G6N8@200795|Chloroflexi,34CYS@301297|Dehalococcoidia	301297|Dehalococcoidia	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
PYH3_k127_7415767_0	255470.cbdbA595	1.631e-202	639.0	COG1243@1|root,COG1243@2|Bacteria,2G5ZZ@200795|Chloroflexi,34CU0@301297|Dehalococcoidia	301297|Dehalococcoidia	BK	Radical_SAM C-terminal domain	-	-	2.3.1.48	ko:K07739	-	-	-	-	ko00000,ko01000,ko03016,ko03036	-	-	-	Acetyltransf_1,Radical_SAM,Radical_SAM_C
PYH3_k127_7415767_2	439235.Dalk_2665	1.974e-90	310.0	COG1960@1|root,COG1960@2|Bacteria,1MUBH@1224|Proteobacteria,42S7G@68525|delta/epsilon subdivisions,2WNH7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
PYH3_k127_7415767_1	439235.Dalk_4173	3.325e-91	314.0	COG1960@1|root,COG1960@2|Bacteria,1MVJC@1224|Proteobacteria,42ZRT@68525|delta/epsilon subdivisions,2WUTK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Acyl-CoA dehydrogenase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
PYH3_k127_7415767_8	1121129.KB903359_gene2324	3.152e-24	116.0	COG0318@1|root,COG0318@2|Bacteria,4PKJY@976|Bacteroidetes,2G0EN@200643|Bacteroidia,2326V@171551|Porphyromonadaceae	976|Bacteroidetes	IQ	GH3 auxin-responsive promoter	-	-	-	-	-	-	-	-	-	-	-	-	GH3
PYH3_k127_7415767_6	1122134.KB893650_gene763	4.632e-36	140.0	COG2827@1|root,COG2827@2|Bacteria,1MZME@1224|Proteobacteria,1S8Z1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	endonuclease containing a URI domain	-	-	-	ko:K07461	-	-	-	-	ko00000	-	-	-	GIY-YIG
PYH3_k127_7415767_7	1304875.JAFZ01000001_gene1089	1.573e-35	138.0	COG2721@1|root,COG2721@2|Bacteria,3TAQD@508458|Synergistetes	508458|Synergistetes	G	D-galactarate dehydratase altronate hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	GD_AH_C
PYH3_k127_74523_4	386456.JQKN01000017_gene840	7.61e-67	233.0	COG4912@1|root,arCOG11010@2157|Archaea,2XWKG@28890|Euryarchaeota,23PIX@183925|Methanobacteria	183925|Methanobacteria	L	DNA alkylation repair enzyme	-	-	-	-	-	-	-	-	-	-	-	-	DNA_alkylation
PYH3_k127_74523_2	768706.Desor_2987	6.543e-86	297.0	COG0183@1|root,COG0183@2|Bacteria,1TT8U@1239|Firmicutes,24FFI@186801|Clostridia,263WE@186807|Peptococcaceae	186801|Clostridia	I	PFAM Thiolase, C-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
PYH3_k127_74523_1	243164.DET0106	1.994e-129	426.0	COG1704@1|root,COG1704@2|Bacteria,2G7BN@200795|Chloroflexi,34CYN@301297|Dehalococcoidia	301297|Dehalococcoidia	S	E3 Ubiquitin ligase	-	-	-	-	-	-	-	-	-	-	-	-	GIDE,LemA
PYH3_k127_74523_10	1499680.CCFE01000025_gene3185	3.128e-11	64.0	2AWWM@1|root,31NU5@2|Bacteria,1TZQ8@1239|Firmicutes,4II4F@91061|Bacilli,1ZJ4J@1386|Bacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_74523_8	986075.CathTA2_0998	1.524e-16	84.0	COG1598@1|root,COG1598@2|Bacteria,1VAII@1239|Firmicutes,4HM80@91061|Bacilli	91061|Bacilli	S	HicB family	-	-	-	-	-	-	-	-	-	-	-	-	HicB
PYH3_k127_74523_7	255470.cbdbB11	7.768e-30	128.0	2A4CG@1|root,30SY4@2|Bacteria,2GAT0@200795|Chloroflexi,34DA6@301297|Dehalococcoidia	301297|Dehalococcoidia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_74523_0	552811.Dehly_0137	2.555e-169	539.0	COG0516@1|root,COG0516@2|Bacteria,2G5ZX@200795|Chloroflexi,34CRY@301297|Dehalococcoidia	301297|Dehalococcoidia	C	IMP dehydrogenase / GMP reductase domain	-	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	IMPDH
PYH3_k127_74523_3	1293054.HSACCH_00481	1.259e-79	282.0	COG0534@1|root,COG0534@2|Bacteria,1TQMT@1239|Firmicutes,249WJ@186801|Clostridia,3WBDR@53433|Halanaerobiales	186801|Clostridia	V	Polysaccharide biosynthesis C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MatE
PYH3_k127_74523_5	760568.Desku_2119	4.863e-60	217.0	2BVIG@1|root,32QWN@2|Bacteria,1VS33@1239|Firmicutes,24YBP@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_74523_6	552811.Dehly_0539	9.267e-46	175.0	COG1938@1|root,COG1938@2|Bacteria,2GAS4@200795|Chloroflexi,34D7S@301297|Dehalococcoidia	301297|Dehalococcoidia	S	PAC2 family	-	-	-	-	-	-	-	-	-	-	-	-	PAC2
PYH3_k127_7458997_8	1121106.JQKB01000006_gene1154	1.17e-19	93.0	COG0346@1|root,COG0346@2|Bacteria,1RB65@1224|Proteobacteria,2U7DP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	MA20_35640	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase,Glyoxalase_4
PYH3_k127_7458997_3	1380387.JADM01000003_gene2658	1.014e-86	299.0	COG1173@1|root,COG1173@2|Bacteria,1MVHY@1224|Proteobacteria,1RR5Y@1236|Gammaproteobacteria,1XNJ2@135619|Oceanospirillales	135619|Oceanospirillales	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
PYH3_k127_7458997_2	1297865.APJD01000009_gene2849	9.569e-113	372.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TR0N@28211|Alphaproteobacteria,3JUIB@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
PYH3_k127_7458997_9	649638.Trad_1790	1.666e-09	68.0	COG4758@1|root,COG4758@2|Bacteria,1WKNW@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF2154
PYH3_k127_7458997_7	1094980.Mpsy_0691	2.054e-20	96.0	COG1983@1|root,arCOG03456@2157|Archaea,2XZT2@28890|Euryarchaeota,2NBEK@224756|Methanomicrobia	224756|Methanomicrobia	K	PspC domain	-	-	-	-	-	-	-	-	-	-	-	-	PspC
PYH3_k127_7458997_5	552811.Dehly_1011	2.162e-48	181.0	COG2928@1|root,COG2928@2|Bacteria,2GAQZ@200795|Chloroflexi,34D4H@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Protein of unknown function (DUF502)	-	-	-	-	-	-	-	-	-	-	-	-	DUF502
PYH3_k127_7458997_1	255470.cbdbA1319	2.206e-126	413.0	COG1313@1|root,COG1313@2|Bacteria,2G65I@200795|Chloroflexi,34CIH@301297|Dehalococcoidia	301297|Dehalococcoidia	C	Radical SAM domain protein	-	-	1.97.1.4	ko:K04070	-	-	-	-	ko00000,ko01000	-	-	-	-
PYH3_k127_7458997_0	1382306.JNIM01000001_gene1396	4.473e-177	568.0	COG0008@1|root,COG0008@2|Bacteria,2G5WU@200795|Chloroflexi	200795|Chloroflexi	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
PYH3_k127_7458997_6	552811.Dehly_0105	1.455e-22	104.0	COG1714@1|root,COG1714@2|Bacteria,2GAT1@200795|Chloroflexi,34DA7@301297|Dehalococcoidia	301297|Dehalococcoidia	S	RDD family	-	-	-	-	-	-	-	-	-	-	-	-	RDD
PYH3_k127_7458997_4	243164.DET1375	8.509e-79	270.0	COG0564@1|root,COG0564@2|Bacteria,2G68N@200795|Chloroflexi,34D96@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Responsible for synthesis of pseudouridine from uracil	-	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
PYH3_k127_7542703_0	439235.Dalk_0125	3.429e-222	711.0	COG2006@1|root,COG2006@2|Bacteria	2|Bacteria	U	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1,CBM9_2,DUF362
PYH3_k127_7542703_3	1123226.KB899282_gene3060	7.254e-61	230.0	COG1680@1|root,COG1680@2|Bacteria,1UZZ5@1239|Firmicutes,4HA1I@91061|Bacilli,274N2@186822|Paenibacillaceae	91061|Bacilli	V	Beta-lactamase	-	-	3.4.16.4	ko:K01286	-	-	-	-	ko00000,ko01000	-	-	-	Beta-lactamase
PYH3_k127_7542703_1	255470.cbdbA1039	3.782e-185	595.0	COG4166@1|root,COG4166@2|Bacteria,2G81T@200795|Chloroflexi,34DKF@301297|Dehalococcoidia	301297|Dehalococcoidia	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	SBP_bac_5
PYH3_k127_7542703_2	311424.DhcVS_931	2.324e-106	350.0	COG0601@1|root,COG0601@2|Bacteria,2G9WT@200795|Chloroflexi,34DMG@301297|Dehalococcoidia	301297|Dehalococcoidia	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K15581	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1
PYH3_k127_7629987_2	255470.cbdbA1052	3.085e-163	522.0	COG0004@1|root,COG0004@2|Bacteria,2G5N8@200795|Chloroflexi,34D2M@301297|Dehalococcoidia	301297|Dehalococcoidia	P	Ammonium Transporter Family	amt	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
PYH3_k127_7629987_5	311424.DhcVS_944	1.28e-38	153.0	COG0745@1|root,COG0745@2|Bacteria,2GARH@200795|Chloroflexi,34D69@301297|Dehalococcoidia	301297|Dehalococcoidia	K	Transcriptional regulatory protein, C terminal	-	-	-	ko:K07658	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Trans_reg_C
PYH3_k127_7629987_4	255470.cbdbA1054	8.384e-95	318.0	COG0070@1|root,COG0070@2|Bacteria,2GAN8@200795|Chloroflexi,34CUP@301297|Dehalococcoidia	301297|Dehalococcoidia	E	GXGXG motif	-	-	-	-	-	-	-	-	-	-	-	-	GXGXG
PYH3_k127_7629987_0	552811.Dehly_0987	8.712e-262	812.0	COG0069@1|root,COG1145@1|root,COG0069@2|Bacteria,COG1145@2|Bacteria,2G5VK@200795|Chloroflexi,34CP2@301297|Dehalococcoidia	301297|Dehalococcoidia	H	Conserved region in glutamate synthase	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_9,Glu_syn_central,Glu_synthase
PYH3_k127_7629987_1	552811.Dehly_0989	6.073e-177	562.0	COG0067@1|root,COG0067@2|Bacteria,2GAS0@200795|Chloroflexi,34D79@301297|Dehalococcoidia	301297|Dehalococcoidia	E	Glutamine amidotransferases class-II	-	-	-	-	-	-	-	-	-	-	-	-	GATase_2
PYH3_k127_7629987_3	552811.Dehly_0990	1.077e-125	416.0	COG1251@1|root,COG1251@2|Bacteria,2G6YZ@200795|Chloroflexi,34D0M@301297|Dehalococcoidia	301297|Dehalococcoidia	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2
PYH3_k127_765546_2	1201290.M902_1577	7.288e-30	122.0	COG0648@1|root,COG0648@2|Bacteria,1N9ZF@1224|Proteobacteria,43EYJ@68525|delta/epsilon subdivisions,2WV80@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	AP endonuclease family 2	-	-	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
PYH3_k127_765546_0	439235.Dalk_5191	3.293e-84	297.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,42NTV@68525|delta/epsilon subdivisions,2WJTP@28221|Deltaproteobacteria,2MIWR@213118|Desulfobacterales	1224|Proteobacteria	C	PFAM CoA-binding domain protein	MA20_15065	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
PYH3_k127_765546_1	880072.Desac_2759	6.971e-41	156.0	COG0406@1|root,COG0406@2|Bacteria,1RHAT@1224|Proteobacteria,42SUD@68525|delta/epsilon subdivisions,2WP5H@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	PFAM Phosphoglycerate mutase	-	-	3.1.3.73	ko:K02226	ko00860,ko01100,map00860,map01100	M00122	R04594,R11173	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
PYH3_k127_7670481_6	269799.Gmet_3382	1.294e-65	241.0	COG5000@1|root,COG5002@1|root,COG5000@2|Bacteria,COG5002@2|Bacteria,1QTV1@1224|Proteobacteria,43BSP@68525|delta/epsilon subdivisions,2X7EK@28221|Deltaproteobacteria,43W43@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	histidine kinase, HAMP	-	-	2.7.13.3	ko:K07642	ko02020,map02020	M00450,M00645,M00646,M00648	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
PYH3_k127_7670481_4	926569.ANT_28720	3.231e-83	282.0	COG0745@1|root,COG0745@2|Bacteria,2G5TG@200795|Chloroflexi	200795|Chloroflexi	K	Two component transcriptional regulator, winged helix family	-	-	-	ko:K07669	ko02020,map02020	M00460	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
PYH3_k127_7670481_7	713587.THITH_13320	3.408e-64	235.0	COG4591@1|root,COG4591@2|Bacteria,1R1KM@1224|Proteobacteria,1T554@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
PYH3_k127_7670481_8	1131269.AQVV01000010_gene2435	2.913e-63	224.0	COG1136@1|root,COG1136@2|Bacteria	2|Bacteria	V	lipoprotein transporter activity	macB	-	-	ko:K02003,ko:K05685	ko02010,map02010	M00258,M00709	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.122.1,3.A.1.122.12	-	-	ABC_tran,FtsX,MacB_PCD
PYH3_k127_7670481_11	997296.PB1_10449	1.561e-08	65.0	COG0526@1|root,COG0526@2|Bacteria,1VAPY@1239|Firmicutes,4HJN1@91061|Bacilli,1ZFAP@1386|Bacillus	91061|Bacilli	CO	COG0526 Thiol-disulfide isomerase and thioredoxins	stoA	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
PYH3_k127_7670481_9	552811.Dehly_0703	1.277e-46	175.0	COG2426@1|root,COG2426@2|Bacteria,2GATG@200795|Chloroflexi,34DB2@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Putative small multi-drug export protein	-	-	-	-	-	-	-	-	-	-	-	-	Sm_multidrug_ex
PYH3_k127_7670481_1	243164.DET0745	6.667e-242	762.0	COG1154@1|root,COG1154@2|Bacteria,2G68R@200795|Chloroflexi,34CZS@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
PYH3_k127_7670481_3	243164.DET0744	1.062e-139	456.0	COG0126@1|root,COG0126@2|Bacteria,2G5UE@200795|Chloroflexi,34D75@301297|Dehalococcoidia	301297|Dehalococcoidia	G	Phosphoglycerate kinase	pgk	-	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
PYH3_k127_7670481_2	243164.DET0743	1.879e-155	499.0	COG3635@1|root,COG3635@2|Bacteria,2GASA@200795|Chloroflexi,34D82@301297|Dehalococcoidia	301297|Dehalococcoidia	C	Metalloenzyme superfamily	-	-	5.4.2.12	ko:K15635	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,PhosphMutase
PYH3_k127_7670481_0	243164.DET0441	5e-324	1002.0	COG0556@1|root,COG0556@2|Bacteria,2G5SU@200795|Chloroflexi,34CU7@301297|Dehalococcoidia	301297|Dehalococcoidia	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
PYH3_k127_7670481_5	1502851.FG93_02074	4.713e-71	256.0	COG2015@1|root,COG2015@2|Bacteria,1MU82@1224|Proteobacteria,2TSM1@28211|Alphaproteobacteria,3JSM0@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Alkyl sulfatase dimerisation	MA20_17395	-	-	-	-	-	-	-	-	-	-	-	Alkyl_sulf_C,Alkyl_sulf_dimr,Lactamase_B
PYH3_k127_7715462_5	644801.Psest_3270	4.932e-07	51.0	COG0313@1|root,COG0313@2|Bacteria,1MU0E@1224|Proteobacteria,1RM7U@1236|Gammaproteobacteria,1Z1U6@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070677,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
PYH3_k127_7715462_4	1449076.JOOE01000003_gene3053	1.445e-10	65.0	2E6S2@1|root,331C5@2|Bacteria,1RH06@1224|Proteobacteria,2U98E@28211|Alphaproteobacteria,2K6C3@204457|Sphingomonadales	204457|Sphingomonadales	S	Signal peptide protein	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_7715462_3	1247963.JPHU01000001_gene2043	4.666e-13	72.0	2E6S2@1|root,331C5@2|Bacteria,1RH06@1224|Proteobacteria,2U98E@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_7715462_1	255470.cbdbA1451	1.04e-89	302.0	COG0159@1|root,COG0159@2|Bacteria,2G6AY@200795|Chloroflexi,34D8X@301297|Dehalococcoidia	301297|Dehalococcoidia	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
PYH3_k127_7715462_0	1382356.JQMP01000004_gene437	4.737e-183	580.0	COG0133@1|root,COG0133@2|Bacteria,2G5Q3@200795|Chloroflexi,27XJP@189775|Thermomicrobia	189775|Thermomicrobia	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	-	-	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
PYH3_k127_7715462_2	572546.Arcpr_0209	2.196e-13	71.0	COG0135@1|root,arCOG01983@2157|Archaea,2XXCM@28890|Euryarchaeota,2469P@183980|Archaeoglobi	183980|Archaeoglobi	E	Belongs to the TrpF family	trpF	-	5.3.1.24	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03509	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	PRAI
PYH3_k127_7724116_2	626418.bglu_1g23090	5.111e-24	110.0	COG2159@1|root,COG2159@2|Bacteria	2|Bacteria	E	amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
PYH3_k127_7724116_0	305700.B447_09503	3.625e-55	208.0	2DBU1@1|root,2ZB3C@2|Bacteria,1NB4B@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_7724116_1	1220534.B655_1171	2.29e-44	164.0	COG0451@1|root,arCOG01369@2157|Archaea,2XUDM@28890|Euryarchaeota	28890|Euryarchaeota	M	NAD-dependent epimerase dehydratase	-	-	1.1.1.219	ko:K00091	-	-	-	-	ko00000,ko01000	-	-	-	Epimerase
PYH3_k127_7859781_1	706587.Desti_0231	2.559e-285	885.0	COG1614@1|root,COG1614@2|Bacteria,1MVI5@1224|Proteobacteria,42N9A@68525|delta/epsilon subdivisions,2WK4H@28221|Deltaproteobacteria,2MQWJ@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	PFAM CO dehydrogenase acetyl-CoA synthase complex beta subunit	-	-	2.3.1.169	ko:K14138	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00377	R08433,R10243	RC00004,RC00113,RC01144,RC02963,RC02964,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhC
PYH3_k127_7859781_0	909663.KI867150_gene97	4.808e-291	906.0	COG0369@1|root,COG1151@2|Bacteria,1NYH2@1224|Proteobacteria,42NE1@68525|delta/epsilon subdivisions,2WIVX@28221|Deltaproteobacteria,2MQ8Q@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	TIGRFAM Carbon-monoxide dehydrogenase, catalytic subunit	-	-	1.2.7.4	ko:K00198	ko00633,ko00680,ko00720,ko01120,ko01200,map00633,map00680,map00720,map01120,map01200	M00377	R07157,R08034	RC00250,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Prismane
PYH3_k127_7859781_2	243164.DET0667	1.354e-126	411.0	COG2069@1|root,COG2069@2|Bacteria,2GAQI@200795|Chloroflexi,34D30@301297|Dehalococcoidia	301297|Dehalococcoidia	C	CO dehydrogenase/acetyl-CoA synthase delta subunit	-	-	2.1.1.245	ko:K00194	ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200	M00357,M00377,M00422	R09096,R10219,R10243	RC00004,RC00113,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhD
PYH3_k127_7859781_3	909663.KI867150_gene99	7.591e-08	57.0	28X5T@1|root,2ZJ48@2|Bacteria,1PA6H@1224|Proteobacteria,433JG@68525|delta/epsilon subdivisions,2WXHP@28221|Deltaproteobacteria,2MSBK@213462|Syntrophobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_7865215_0	255470.cbdbA766	1.23e-118	395.0	COG0420@1|root,COG0420@2|Bacteria,2G60M@200795|Chloroflexi,34CXW@301297|Dehalococcoidia	301297|Dehalococcoidia	L	SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity	sbcD	-	-	ko:K03547	-	-	-	-	ko00000,ko03400	-	-	-	Metallophos
PYH3_k127_7865215_1	479434.Sthe_3125	1.096e-77	275.0	COG0477@1|root,COG2814@2|Bacteria,2G6HS@200795|Chloroflexi,27XYB@189775|Thermomicrobia	189775|Thermomicrobia	EGP	MFS_1 like family	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
PYH3_k127_7865215_2	1429916.X566_17380	1.66e-76	265.0	COG1024@1|root,COG1024@2|Bacteria,1R446@1224|Proteobacteria,2U280@28211|Alphaproteobacteria	2|Bacteria	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
PYH3_k127_7872683_0	255470.cbdbA65	2.927e-154	494.0	COG0013@1|root,COG0013@2|Bacteria,2G5KW@200795|Chloroflexi,34CVN@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
PYH3_k127_7872683_1	255470.cbdbA496	1.927e-104	349.0	COG0312@1|root,COG0312@2|Bacteria,2GBVJ@200795|Chloroflexi,34CYG@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Putative modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
PYH3_k127_7931203_3	1828.JOKB01000028_gene2151	1.306e-32	132.0	COG2267@1|root,COG2267@2|Bacteria,2GPA8@201174|Actinobacteria,4FW0U@85025|Nocardiaceae	201174|Actinobacteria	I	Serine aminopeptidase, S33	ytpA	GO:0001906,GO:0001907,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006629,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0010941,GO:0010942,GO:0016020,GO:0016042,GO:0016298,GO:0016787,GO:0016788,GO:0030312,GO:0031341,GO:0031343,GO:0031640,GO:0035821,GO:0042981,GO:0043065,GO:0043067,GO:0043068,GO:0043900,GO:0043902,GO:0043903,GO:0044003,GO:0044004,GO:0044068,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044364,GO:0044403,GO:0044419,GO:0044464,GO:0044531,GO:0044532,GO:0044533,GO:0046486,GO:0046503,GO:0047372,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051701,GO:0051704,GO:0051709,GO:0051712,GO:0051817,GO:0051818,GO:0051883,GO:0052040,GO:0052042,GO:0052150,GO:0052151,GO:0052248,GO:0052330,GO:0052433,GO:0052501,GO:0052689,GO:0065007,GO:0071704,GO:0071944,GO:1901575	3.1.1.5	ko:K01048	ko00564,map00564	-	-	-	ko00000,ko00001,ko01000	-	-	-	Hydrolase_4
PYH3_k127_7931203_0	246194.CHY_1329	3.189e-226	716.0	COG2414@1|root,COG2414@2|Bacteria,1TSZ8@1239|Firmicutes,24DA3@186801|Clostridia,42JCT@68295|Thermoanaerobacterales	186801|Clostridia	C	Aldehyde ferredoxin oxidoreductase, domains 2 & 3	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
PYH3_k127_7931203_2	1429916.X566_23700	3.348e-66	236.0	COG2021@1|root,COG2021@2|Bacteria	2|Bacteria	E	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine	rutD	GO:0006139,GO:0006206,GO:0006208,GO:0006212,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0017144,GO:0019740,GO:0019860,GO:0034641,GO:0042737,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0046113,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072527,GO:0072529,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575	3.1.1.24,3.4.11.5,4.1.1.44	ko:K01055,ko:K01259,ko:K09023,ko:K14727,ko:K16434	ko00240,ko00330,ko00362,ko01055,ko01100,ko01120,ko01220,map00240,map00330,map00362,map01055,map01100,map01120,map01220	M00568	R00135,R02991,R03470,R09983	RC00825,RC00938,RC02769	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	iEC55989_1330.EC55989_1120,iECO26_1355.ECO26_1247,iECUMN_1333.ECUMN_1192,iSF_1195.SF1012,iSFxv_1172.SFxv_1098,iSSON_1240.SSON_1027,iS_1188.S1082,ic_1306.c1146	Abhydrolase_1,Abhydrolase_4,Abhydrolase_6,CMD
PYH3_k127_7931203_1	243164.DET1416	2.438e-119	389.0	COG0150@1|root,COG0150@2|Bacteria,2G5YZ@200795|Chloroflexi,34D95@301297|Dehalococcoidia	301297|Dehalococcoidia	F	AIR synthase related protein, C-terminal domain	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
PYH3_k127_7934104_7	311424.DhcVS_274	1.609e-76	268.0	COG0341@1|root,COG0341@2|Bacteria,2G696@200795|Chloroflexi,34CSD@301297|Dehalococcoidia	301297|Dehalococcoidia	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	-	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
PYH3_k127_7934104_3	311424.DhcVS_275	1.277e-146	477.0	COG0342@1|root,COG0342@2|Bacteria,2G5K5@200795|Chloroflexi,34CQF@301297|Dehalococcoidia	301297|Dehalococcoidia	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF
PYH3_k127_7934104_4	552811.Dehly_1469	1.424e-117	395.0	COG0617@1|root,COG0617@2|Bacteria,2G6B7@200795|Chloroflexi,34D7X@301297|Dehalococcoidia	301297|Dehalococcoidia	J	tRNA nucleotidyltransferase domain 2 putative	-	-	2.7.7.19	ko:K00970	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PolyA_pol,PolyA_pol_RNAbd,tRNA_NucTran2_2
PYH3_k127_7934104_9	552811.Dehly_0832	3.168e-67	237.0	COG0377@1|root,COG0377@2|Bacteria,2G6BJ@200795|Chloroflexi,34CJ7@301297|Dehalococcoidia	301297|Dehalococcoidia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoB	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
PYH3_k127_7934104_13	1122947.FR7_0188	4.913e-30	124.0	COG0852@1|root,COG0852@2|Bacteria,1UFNI@1239|Firmicutes,4H5IH@909932|Negativicutes	909932|Negativicutes	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
PYH3_k127_7934104_1	552811.Dehly_0834	1.337e-158	507.0	COG0649@1|root,COG0649@2|Bacteria,2G5JF@200795|Chloroflexi,34D5Q@301297|Dehalococcoidia	301297|Dehalococcoidia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
PYH3_k127_7934104_6	552811.Dehly_0835	7.702e-109	363.0	COG1005@1|root,COG1005@2|Bacteria,2G60S@200795|Chloroflexi,34CTC@301297|Dehalococcoidia	301297|Dehalococcoidia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
PYH3_k127_7934104_11	311424.DhcVS_799	4.188e-35	139.0	COG1143@1|root,COG1143@2|Bacteria,2G6P8@200795|Chloroflexi,34CJH@301297|Dehalococcoidia	301297|Dehalococcoidia	C	4Fe-4S dicluster domain	-	-	1.6.5.3	ko:K05580	ko00190,ko01100,map00190,map01100	M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4
PYH3_k127_7934104_10	255470.cbdbA881	3.076e-38	148.0	COG0839@1|root,COG0839@2|Bacteria,2G777@200795|Chloroflexi,34CMP@301297|Dehalococcoidia	301297|Dehalococcoidia	C	Belongs to the complex I subunit 6 family	-	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
PYH3_k127_7934104_12	552811.Dehly_0838	1.001e-32	130.0	COG0713@1|root,COG0713@2|Bacteria,2G782@200795|Chloroflexi,34DFJ@301297|Dehalococcoidia	301297|Dehalococcoidia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK	-	1.6.5.3	ko:K05576	ko00190,ko01100,map00190,map01100	M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	-	-	-	Oxidored_q2
PYH3_k127_7934104_0	552811.Dehly_0839	1.07e-219	699.0	COG1009@1|root,COG1009@2|Bacteria,2G5NJ@200795|Chloroflexi,34D55@301297|Dehalococcoidia	301297|Dehalococcoidia	CP	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus	-	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
PYH3_k127_7934104_5	269799.Gmet_3343	2.493e-116	391.0	COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,42NGD@68525|delta/epsilon subdivisions,2WJDC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M	nuoM	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q5_N,Proton_antipo_M
PYH3_k127_7934104_2	552811.Dehly_0841	1.033e-150	490.0	COG1007@1|root,COG1007@2|Bacteria,2G5ZK@200795|Chloroflexi,34D3B@301297|Dehalococcoidia	301297|Dehalococcoidia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q5_N,Proton_antipo_M
PYH3_k127_7934104_8	552811.Dehly_0801	9.092e-73	252.0	COG2896@1|root,COG2896@2|Bacteria,2G5JT@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Mob_synth_C,Radical_SAM
PYH3_k127_797998_3	944480.ATUV01000001_gene606	3.161e-05	49.0	COG0183@1|root,COG0183@2|Bacteria,1MUZV@1224|Proteobacteria,42NTN@68525|delta/epsilon subdivisions,2WK18@28221|Deltaproteobacteria,2M7IZ@213113|Desulfurellales	28221|Deltaproteobacteria	I	acetyl-coa acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_797998_2	485913.Krac_4978	4.66e-19	96.0	COG0517@1|root,COG1994@1|root,COG0517@2|Bacteria,COG1994@2|Bacteria,2G5WG@200795|Chloroflexi	200795|Chloroflexi	S	Belongs to the peptidase M50B family	-	-	-	-	-	-	-	-	-	-	-	-	CBS,Peptidase_M50
PYH3_k127_797998_0	1380390.JIAT01000009_gene1057	2.858e-81	278.0	COG2197@1|root,COG2197@2|Bacteria,2GJ46@201174|Actinobacteria,4CSY6@84995|Rubrobacteria	84995|Rubrobacteria	K	Two component transcriptional regulator, LuxR family	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
PYH3_k127_797998_1	1306174.JODP01000003_gene1842	6.887e-65	237.0	COG4585@1|root,COG4585@2|Bacteria,2GJEG@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
PYH3_k127_797998_4	255470.cbdbA1633	0.0001452	49.0	2A4DT@1|root,30SZM@2|Bacteria,2GAV3@200795|Chloroflexi,34DER@301297|Dehalococcoidia	301297|Dehalococcoidia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_797998_5	552811.Dehly_1718	0.0003761	47.0	COG0515@1|root,COG0515@2|Bacteria,2GA62@200795|Chloroflexi,34D89@301297|Dehalococcoidia	301297|Dehalococcoidia	KLT	Putative auto-transporter adhesin, head GIN domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF2807
PYH3_k127_7994230_4	1172185.KB911532_gene64	2.234e-78	277.0	COG1804@1|root,COG1804@2|Bacteria,2GRB0@201174|Actinobacteria,4FW2K@85025|Nocardiaceae	201174|Actinobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
PYH3_k127_7994230_2	1101188.KI912155_gene2983	8.722e-91	314.0	COG1804@1|root,COG1804@2|Bacteria,2IB9E@201174|Actinobacteria	201174|Actinobacteria	C	L-carnitine dehydratase bile acid-inducible protein F	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
PYH3_k127_7994230_3	767817.Desgi_0669	3.344e-80	286.0	COG1804@1|root,COG1804@2|Bacteria,1TP54@1239|Firmicutes,24AFB@186801|Clostridia	186801|Clostridia	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
PYH3_k127_7994230_8	698769.JFBD01000042_gene814	1.716e-05	49.0	2DR03@1|root,339MB@2|Bacteria,1VK6Y@1239|Firmicutes,4HR34@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_7994230_6	381666.H16_B0719	5.751e-27	127.0	COG1173@1|root,COG1173@2|Bacteria,1MU26@1224|Proteobacteria,2W02P@28216|Betaproteobacteria,1KDF1@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
PYH3_k127_7994230_5	562970.Btus_1052	1.809e-27	120.0	COG1309@1|root,COG1309@2|Bacteria,1UZQU@1239|Firmicutes,4HD4B@91061|Bacilli,2789S@186823|Alicyclobacillaceae	91061|Bacilli	K	Bacterial regulatory proteins, tetR family	kstR2_2	-	-	-	-	-	-	-	-	-	-	-	TetR_N
PYH3_k127_7994230_0	1499680.CCFE01000023_gene2574	9.047e-107	359.0	COG1804@1|root,COG1804@2|Bacteria,1TP54@1239|Firmicutes,4HABI@91061|Bacilli,1ZM1F@1386|Bacillus	91061|Bacilli	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
PYH3_k127_7994230_1	1499680.CCFE01000023_gene2573	2.155e-95	324.0	COG1804@1|root,COG1804@2|Bacteria,1TP54@1239|Firmicutes,4HABI@91061|Bacilli,1ZM1C@1386|Bacillus	91061|Bacilli	C	CoA-transferase family III	frc	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
PYH3_k127_8013713_1	644282.Deba_3173	3.544e-81	274.0	COG0709@1|root,COG0709@2|Bacteria,1MWFG@1224|Proteobacteria,42MC3@68525|delta/epsilon subdivisions,2WK3M@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Synthesizes selenophosphate from selenide and ATP	selD	-	2.7.9.3	ko:K01008	ko00450,ko01100,map00450,map01100	-	R03595	RC00002,RC02878	ko00000,ko00001,ko01000,ko03016	-	-	-	AIRS,AIRS_C
PYH3_k127_8013713_0	7165.AGAP008366-PA	3.32e-134	466.0	COG2373@1|root,KOG1366@2759|Eukaryota,38DGN@33154|Opisthokonta,3BCF2@33208|Metazoa,3CTZZ@33213|Bilateria,41UV6@6656|Arthropoda,3SI6H@50557|Insecta,44ZC1@7147|Diptera,45JRF@7148|Nematocera	33208|Metazoa	O	Alpha-2-Macroglobulin	CD109	GO:0000768,GO:0001932,GO:0001933,GO:0001942,GO:0002376,GO:0002520,GO:0002521,GO:0002573,GO:0002576,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005615,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006810,GO:0006887,GO:0006949,GO:0006950,GO:0006952,GO:0007275,GO:0008150,GO:0008285,GO:0008544,GO:0009605,GO:0009607,GO:0009617,GO:0009620,GO:0009653,GO:0009888,GO:0009892,GO:0009966,GO:0009968,GO:0009987,GO:0010563,GO:0010605,GO:0010646,GO:0010648,GO:0010837,GO:0010839,GO:0012505,GO:0012506,GO:0016020,GO:0016192,GO:0017015,GO:0019220,GO:0019222,GO:0019838,GO:0019955,GO:0022404,GO:0022405,GO:0023051,GO:0023057,GO:0030097,GO:0030099,GO:0030141,GO:0030154,GO:0030316,GO:0030512,GO:0030659,GO:0030667,GO:0030856,GO:0031090,GO:0031091,GO:0031092,GO:0031323,GO:0031324,GO:0031399,GO:0031400,GO:0031410,GO:0031982,GO:0032101,GO:0032102,GO:0032268,GO:0032269,GO:0032501,GO:0032502,GO:0032940,GO:0042127,GO:0042303,GO:0042325,GO:0042326,GO:0042633,GO:0042742,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043588,GO:0044421,GO:0044422,GO:0044424,GO:0044433,GO:0044444,GO:0044446,GO:0044464,GO:0045055,GO:0045595,GO:0045604,GO:0045616,GO:0045682,GO:0045936,GO:0046903,GO:0048513,GO:0048519,GO:0048523,GO:0048534,GO:0048583,GO:0048585,GO:0048646,GO:0048731,GO:0048856,GO:0048869,GO:0050431,GO:0050678,GO:0050680,GO:0050789,GO:0050793,GO:0050794,GO:0050829,GO:0050830,GO:0050896,GO:0051171,GO:0051172,GO:0051174,GO:0051179,GO:0051234,GO:0051239,GO:0051246,GO:0051248,GO:0051704,GO:0051707,GO:0060255,GO:0060429,GO:0061041,GO:0061045,GO:0065007,GO:0071944,GO:0072674,GO:0072675,GO:0080090,GO:0080134,GO:0090092,GO:0090101,GO:0090287,GO:0090288,GO:0097708,GO:0098542,GO:0098588,GO:0098773,GO:0098805,GO:0099503,GO:1903034,GO:1903035,GO:1903844,GO:1903845,GO:2000026	-	ko:K03910,ko:K06530	ko04610,map04610	-	-	-	ko00000,ko00001,ko04090,ko04131,ko04147	-	-	-	A2M,A2M_N,A2M_N_2,A2M_comp,A2M_recep,Thiol-ester_cl
PYH3_k127_8028051_18	251221.35210651	2.882e-22	101.0	COG1670@1|root,COG1670@2|Bacteria,1G7I7@1117|Cyanobacteria	1117|Cyanobacteria	J	Acetyltransferase (GNAT) domain	-	-	-	ko:K03817	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_3
PYH3_k127_8028051_26	411477.PARMER_02386	3.186e-05	46.0	2A5P9@1|root,30UE4@2|Bacteria,4NZ0B@976|Bacteroidetes,2G1I9@200643|Bacteroidia,22YXV@171551|Porphyromonadaceae	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_8028051_24	1122915.AUGY01000118_gene6532	3.522e-14	85.0	COG2223@1|root,COG2223@2|Bacteria	2|Bacteria	P	nitrite transmembrane transporter activity	-	-	-	ko:K02575,ko:K08223	ko00910,map00910	M00615	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.35,2.A.1.8	-	-	MFS_1
PYH3_k127_8028051_4	243164.DET0718	1.326e-127	418.0	COG0758@1|root,COG0758@2|Bacteria,2G5UA@200795|Chloroflexi,34CU9@301297|Dehalococcoidia	301297|Dehalococcoidia	L	DNA recombination-mediator protein A	-	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
PYH3_k127_8028051_0	255470.cbdbA674	5.627e-259	816.0	COG0550@1|root,COG0550@2|Bacteria,2G5ZR@200795|Chloroflexi,34CQ8@301297|Dehalococcoidia	301297|Dehalococcoidia	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,zf-C4_Topoisom
PYH3_k127_8028051_8	243164.DET0716	1.573e-95	321.0	COG4974@1|root,COG4974@2|Bacteria,2G6CI@200795|Chloroflexi,34CTP@301297|Dehalococcoidia	301297|Dehalococcoidia	D	Phage integrase, N-terminal SAM-like domain	xerC	-	-	ko:K03733	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
PYH3_k127_8028051_7	243164.DET0715	3.876e-100	338.0	COG0006@1|root,COG0006@2|Bacteria,2G6AE@200795|Chloroflexi,34CW7@301297|Dehalococcoidia	301297|Dehalococcoidia	E	Creatinase/Prolidase N-terminal domain	-	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
PYH3_k127_8028051_13	243164.DET0713	7.082e-61	217.0	COG0613@1|root,COG0613@2|Bacteria,2G74N@200795|Chloroflexi,34CIK@301297|Dehalococcoidia	301297|Dehalococcoidia	S	PHP-associated	-	-	-	-	-	-	-	-	-	-	-	-	PHP,PHP_C
PYH3_k127_8028051_12	243164.DET0712	6.346e-81	277.0	COG0299@1|root,COG0299@2|Bacteria,2GANQ@200795|Chloroflexi,34CW6@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Formyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Formyl_trans_N
PYH3_k127_8028051_6	311424.DhcVS_617	2.658e-101	332.0	COG0740@1|root,COG0740@2|Bacteria,2G6BN@200795|Chloroflexi,34D07@301297|Dehalococcoidia	301297|Dehalococcoidia	O	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
PYH3_k127_8028051_9	243164.DET0709	6.446e-95	326.0	COG0544@1|root,COG0544@2|Bacteria,2G6GA@200795|Chloroflexi,34D4G@301297|Dehalococcoidia	301297|Dehalococcoidia	D	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03545	-	-	-	-	ko00000	-	-	-	Trigger_C,Trigger_N
PYH3_k127_8028051_1	255470.cbdbA663	1.538e-236	745.0	COG0173@1|root,COG0173@2|Bacteria,2G5RX@200795|Chloroflexi,34CSB@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
PYH3_k127_8028051_10	1295642.H839_13549	2.809e-89	307.0	COG0183@1|root,COG0183@2|Bacteria,1TT8U@1239|Firmicutes,4HDWF@91061|Bacilli	91061|Bacilli	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
PYH3_k127_8028051_22	439481.Aboo_0340	4.897e-16	83.0	COG1545@1|root,arCOG01285@2157|Archaea,2XXGF@28890|Euryarchaeota,3F2RZ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	V	DUF35 OB-fold domain, acyl-CoA-associated	acaC	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
PYH3_k127_8028051_5	555079.Toce_1134	1.03e-101	356.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,247V1@186801|Clostridia,42EQG@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM NADH flavin oxidoreductase NADH oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN,Pyr_redox_2
PYH3_k127_8028051_3	552811.Dehly_0136	1.952e-149	480.0	COG2876@1|root,COG2876@2|Bacteria,2G643@200795|Chloroflexi,34CWK@301297|Dehalococcoidia	301297|Dehalococcoidia	H	NeuB family	-	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
PYH3_k127_8028051_16	1403313.AXBR01000017_gene3597	1.905e-35	147.0	COG2070@1|root,COG2070@2|Bacteria,1TPC3@1239|Firmicutes,4H9T0@91061|Bacilli,1ZETK@1386|Bacillus	91061|Bacilli	S	FMN-dependent dehydrogenase	-	-	1.13.12.16	ko:K00459	ko00910,map00910	-	R00025	RC02541,RC02759	ko00000,ko00001,ko01000	-	-	-	NMO
PYH3_k127_8028051_21	1380347.JNII01000009_gene2022	2.798e-18	91.0	COG2318@1|root,COG2318@2|Bacteria,2II1I@201174|Actinobacteria,4ET39@85013|Frankiales	201174|Actinobacteria	S	Protein of unknown function (DUF664)	-	-	-	-	-	-	-	-	-	-	-	-	DUF664,DinB_2
PYH3_k127_8028051_20	485915.Dret_0449	1.072e-20	96.0	COG0375@1|root,COG0375@2|Bacteria,1PTY5@1224|Proteobacteria,42U07@68525|delta/epsilon subdivisions,2WPIB@28221|Deltaproteobacteria,2MCEE@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Probably plays a role in a hydrogenase nickel cofactor insertion step	hypA	-	-	ko:K04651	-	-	-	-	ko00000,ko03110	-	-	-	HypA
PYH3_k127_8028051_11	439235.Dalk_1647	4.03e-87	301.0	COG1149@1|root,COG1149@2|Bacteria	2|Bacteria	C	4 iron, 4 sulfur cluster binding	ldpA	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_6,LdpA_C
PYH3_k127_8028051_15	255470.cbdbA1418	2.129e-38	148.0	COG2105@1|root,COG2105@2|Bacteria,2GATP@200795|Chloroflexi,34DBH@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Gamma-glutamyl cyclotransferase, AIG2-like	-	-	-	-	-	-	-	-	-	-	-	-	GGACT
PYH3_k127_8028051_17	1178825.ALIH01000001_gene2495	3.184e-23	108.0	COG0584@1|root,COG0584@2|Bacteria,4NGNU@976|Bacteroidetes,1HYHS@117743|Flavobacteriia	976|Bacteroidetes	C	glycerophosphoryl diester phosphodiesterase	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
PYH3_k127_8028051_14	767817.Desgi_0472	1.029e-54	201.0	COG1024@1|root,COG1024@2|Bacteria,1TQ89@1239|Firmicutes,247RK@186801|Clostridia,26121@186807|Peptococcaceae	186801|Clostridia	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	-	ECH_1
PYH3_k127_8028051_25	1169144.KB910984_gene3830	2.41e-13	82.0	COG0477@1|root,COG2814@2|Bacteria,1V36U@1239|Firmicutes,4HJX6@91061|Bacilli,1ZGAC@1386|Bacillus	91061|Bacilli	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like
PYH3_k127_8028051_2	1382306.JNIM01000001_gene663	1.501e-159	531.0	COG2366@1|root,COG2366@2|Bacteria,2G63N@200795|Chloroflexi	200795|Chloroflexi	S	PFAM peptidase S45 penicillin amidase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
PYH3_k127_8028051_27	136273.GY22_07665	0.0006972	44.0	2AY0M@1|root,31Q26@2|Bacteria,2IMBI@201174|Actinobacteria,1WC78@1268|Micrococcaceae	201174|Actinobacteria	S	Phospholipase_D-nuclease N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_N,SHOCT
PYH3_k127_8028051_23	1167006.UWK_03444	1.969e-15	86.0	COG2197@1|root,COG3852@1|root,COG2197@2|Bacteria,COG3852@2|Bacteria,1R2HI@1224|Proteobacteria,42ZPI@68525|delta/epsilon subdivisions,2WUU1@28221|Deltaproteobacteria,2MPPT@213118|Desulfobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,PAS_4,Response_reg
PYH3_k127_8029783_0	552811.Dehly_0428	0.0	1545.0	COG0587@1|root,COG0587@2|Bacteria,2G5IY@200795|Chloroflexi,34CSK@301297|Dehalococcoidia	2|Bacteria	L	DNA-directed DNA polymerase	dnaE2	GO:0000731,GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019985,GO:0030312,GO:0031668,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0042276,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0046483,GO:0046677,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576	2.7.7.6,2.7.7.7	ko:K00960,ko:K02337,ko:K14162	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
PYH3_k127_8029783_11	469383.Cwoe_4250	5.178e-08	57.0	290AJ@1|root,2ZN05@2|Bacteria,2HRSY@201174|Actinobacteria,4CTW7@84995|Rubrobacteria	84995|Rubrobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_8029783_4	552811.Dehly_0426	4.225e-121	400.0	COG0389@1|root,COG0389@2|Bacteria,2G6I6@200795|Chloroflexi,34CJ5@301297|Dehalococcoidia	301297|Dehalococcoidia	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	GO:0003674,GO:0003824,GO:0003887,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
PYH3_k127_8029783_1	1121468.AUBR01000038_gene1955	1.913e-162	522.0	COG1960@1|root,COG1960@2|Bacteria,1TP57@1239|Firmicutes,247UB@186801|Clostridia,42FF9@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM Acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
PYH3_k127_8029783_8	335543.Sfum_0638	7.613e-65	235.0	COG0730@1|root,COG0730@2|Bacteria,1NX2Y@1224|Proteobacteria,42P1U@68525|delta/epsilon subdivisions,2WJZV@28221|Deltaproteobacteria	1224|Proteobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
PYH3_k127_8029783_5	311424.DhcVS_45	2.383e-113	377.0	COG0012@1|root,COG0012@2|Bacteria,2G5UY@200795|Chloroflexi,34CT5@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Protein of unknown function (DUF933)	-	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	YchF-GTPase_C
PYH3_k127_8029783_10	243164.DET1585	1.986e-30	124.0	COG3809@1|root,COG3809@2|Bacteria,2GAUV@200795|Chloroflexi,34DEB@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Transcription factor zinc-finger	-	-	-	ko:K09981	-	-	-	-	ko00000	-	-	-	zf-TFIIB
PYH3_k127_8029783_7	552811.Dehly_1171	1.856e-66	232.0	COG1704@1|root,COG1704@2|Bacteria,2GAPS@200795|Chloroflexi,34D06@301297|Dehalococcoidia	301297|Dehalococcoidia	S	LemA family	-	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
PYH3_k127_8029783_2	311424.DhcVS_1471	4.677e-153	493.0	COG0501@1|root,COG0501@2|Bacteria,2G6UV@200795|Chloroflexi,34D0W@301297|Dehalococcoidia	301297|Dehalococcoidia	O	Peptidase family M48	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
PYH3_k127_8029783_9	509191.AEDB02000086_gene2765	7.279e-41	155.0	COG1959@1|root,COG1959@2|Bacteria,1V3QB@1239|Firmicutes,24JIV@186801|Clostridia,3WJN5@541000|Ruminococcaceae	186801|Clostridia	K	Transcriptional regulator	iscR	-	-	-	-	-	-	-	-	-	-	-	Rrf2
PYH3_k127_8029783_3	370438.PTH_0247	1.529e-139	449.0	COG0031@1|root,COG0031@2|Bacteria,1TP30@1239|Firmicutes,2497G@186801|Clostridia,260EI@186807|Peptococcaceae	186801|Clostridia	E	Belongs to the cysteine synthase cystathionine beta- synthase family	cysK	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
PYH3_k127_8029783_6	243164.DET1588	1.817e-84	285.0	COG1045@1|root,COG1045@2|Bacteria,2G6DI@200795|Chloroflexi,34D9R@301297|Dehalococcoidia	301297|Dehalococcoidia	E	Bacterial transferase hexapeptide (six repeats)	cysE	-	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep
PYH3_k127_8029783_13	1121405.dsmv_3459	7.437e-05	47.0	COG2122@1|root,COG2122@2|Bacteria,1MV9Z@1224|Proteobacteria,42PMZ@68525|delta/epsilon subdivisions,2WMF7@28221|Deltaproteobacteria,2MJ13@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM ApbE family	-	-	-	ko:K09740	-	-	-	-	ko00000	-	-	-	-
PYH3_k127_8036033_1	1121472.AQWN01000004_gene767	3.881e-155	496.0	COG0554@1|root,COG0554@2|Bacteria,1TPX3@1239|Firmicutes,2493W@186801|Clostridia,2618F@186807|Peptococcaceae	186801|Clostridia	F	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK	GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
PYH3_k127_8036033_2	998674.ATTE01000001_gene1020	3.375e-76	264.0	COG2267@1|root,COG2267@2|Bacteria,1MWF5@1224|Proteobacteria,1RNQR@1236|Gammaproteobacteria,462NN@72273|Thiotrichales	72273|Thiotrichales	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
PYH3_k127_8036033_3	1338011.BD94_0225	5.158e-53	213.0	COG5373@1|root,COG5373@2|Bacteria,4NGKV@976|Bacteroidetes,1HZB4@117743|Flavobacteriia,34QIF@308865|Elizabethkingia	976|Bacteroidetes	S	Predicted membrane protein (DUF2339)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2339
PYH3_k127_8036033_0	706587.Desti_0062	1.995e-202	634.0	COG0458@1|root,COG0458@2|Bacteria,1NPMZ@1224|Proteobacteria,42NF3@68525|delta/epsilon subdivisions,2WM4C@28221|Deltaproteobacteria,2MQ8X@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	Carbamoyl-phosphate synthetase large chain, oligomerisation	-	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_0661	CPSase_L_D2,CPSase_L_D3,MGS
PYH3_k127_8044397_3	1121468.AUBR01000059_gene888	1.97e-109	362.0	COG2509@1|root,COG2509@2|Bacteria,1TP9I@1239|Firmicutes,247QM@186801|Clostridia,42FH5@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM FAD dependent oxidoreductase	-	-	-	ko:K07137	-	-	-	-	ko00000	-	-	-	FAD_binding_2,HI0933_like,Pyr_redox_2,Thi4
PYH3_k127_8044397_9	243164.DET0356	6.311e-13	71.0	2A3V0@1|root,30SD1@2|Bacteria,2GAY5@200795|Chloroflexi,34DJT@301297|Dehalococcoidia	301297|Dehalococcoidia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_8044397_1	311424.DhcVS_298	2.205e-170	556.0	2BPNS@1|root,32IFU@2|Bacteria,2GAX7@200795|Chloroflexi,34DII@301297|Dehalococcoidia	301297|Dehalococcoidia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_8044397_6	311424.DhcVS_297	9.574e-35	134.0	2A4I8@1|root,30T4T@2|Bacteria,2G9XB@200795|Chloroflexi,34DQD@301297|Dehalococcoidia	301297|Dehalococcoidia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_8044397_4	311424.DhcVS_296	2.421e-48	180.0	2A4RY@1|root,30TDC@2|Bacteria,2GB08@200795|Chloroflexi,34DPC@301297|Dehalococcoidia	301297|Dehalococcoidia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_8044397_10	391625.PPSIR1_29810	1.687e-09	67.0	COG1196@1|root,COG1572@1|root,COG2931@1|root,COG1196@2|Bacteria,COG1572@2|Bacteria,COG2931@2|Bacteria,1NFCP@1224|Proteobacteria	1224|Proteobacteria	M	Concanavalin A-like lectin/glucanases superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3
PYH3_k127_8044397_2	311424.DhcVS_295	2.449e-153	488.0	2DBIJ@1|root,2Z9G2@2|Bacteria,2G896@200795|Chloroflexi,34DN7@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Phage capsid family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_capsid
PYH3_k127_8044397_0	311424.DhcVS_293	1.45e-177	567.0	COG3567@1|root,COG3567@2|Bacteria,2G7F0@200795|Chloroflexi,34DDN@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Phage portal protein, SPP1 Gp6-like	-	-	-	-	-	-	-	-	-	-	-	-	Phage_prot_Gp6
PYH3_k127_8044397_8	311424.DhcVS_292	1.436e-16	82.0	2A3TQ@1|root,30SBK@2|Bacteria,2G9W9@200795|Chloroflexi,34DJK@301297|Dehalococcoidia	301297|Dehalococcoidia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_8044397_5	552811.Dehly_0860	8.821e-42	157.0	COG1611@1|root,COG1611@2|Bacteria,2G6YH@200795|Chloroflexi,34CSH@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Possible lysine decarboxylase	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	DNA_processg_A
PYH3_k127_8086420_3	632518.Calow_1750	1.922e-11	65.0	COG0004@1|root,COG0004@2|Bacteria,1TQYG@1239|Firmicutes,247W1@186801|Clostridia,42F7G@68295|Thermoanaerobacterales	186801|Clostridia	P	TIGRFAM Ammonium transporter	amt	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	iHN637.CLJU_c42670	Ammonium_transp
PYH3_k127_8086420_2	243164.DET1124	4.057e-39	148.0	COG0347@1|root,COG0347@2|Bacteria,2G9JD@200795|Chloroflexi,34DDF@301297|Dehalococcoidia	301297|Dehalococcoidia	K	Nitrogen regulatory protein P-II	-	-	-	ko:K04751	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
PYH3_k127_8086420_0	552811.Dehly_0559	7.327e-220	688.0	COG0174@1|root,COG0174@2|Bacteria,2G5U2@200795|Chloroflexi,34CUT@301297|Dehalococcoidia	301297|Dehalococcoidia	E	Glutamine synthetase, catalytic domain	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
PYH3_k127_8086420_4	1122921.KB898201_gene3193	0.0006033	49.0	COG2159@1|root,COG2159@2|Bacteria,1V0UC@1239|Firmicutes,4HNEI@91061|Bacilli,2701T@186822|Paenibacillaceae	91061|Bacilli	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
PYH3_k127_8135633_3	1121472.AQWN01000001_gene238	2.15e-92	317.0	COG3875@1|root,COG3875@2|Bacteria,1TQ1C@1239|Firmicutes,247PH@186801|Clostridia,261WJ@186807|Peptococcaceae	186801|Clostridia	S	conserved protein (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
PYH3_k127_8135633_6	357809.Cphy_3059	4.235e-13	76.0	2CIJU@1|root,332RU@2|Bacteria,1VESI@1239|Firmicutes,24QR7@186801|Clostridia	186801|Clostridia	S	Domain of unknown function (DUF1893)	-	-	-	-	-	-	-	-	-	-	-	-	TM1506
PYH3_k127_8135633_0	1449126.JQKL01000033_gene1201	4.968e-173	555.0	COG2368@1|root,COG2368@2|Bacteria,1TQ70@1239|Firmicutes,248RP@186801|Clostridia,267KG@186813|unclassified Clostridiales	186801|Clostridia	Q	4-hydroxyphenylacetate 3-hydroxylase C terminal	-	-	1.14.14.9	ko:K00483	ko00350,ko01120,ko01220,map00350,map01120,map01220	-	R02698,R03299	RC00046	ko00000,ko00001,ko01000	-	-	-	HpaB,HpaB_N
PYH3_k127_8135633_1	269799.Gmet_2198	2.878e-98	334.0	COG1960@1|root,COG1960@2|Bacteria,1MUBH@1224|Proteobacteria,42S7G@68525|delta/epsilon subdivisions,2WNH7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
PYH3_k127_8135633_2	552811.Dehly_0237	5.084e-93	313.0	COG0761@1|root,COG0761@2|Bacteria,2G75Z@200795|Chloroflexi,34CJU@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	-	LYTB
PYH3_k127_8135633_4	1449126.JQKL01000010_gene399	8.193e-34	139.0	COG0204@1|root,COG0204@2|Bacteria,1U8N2@1239|Firmicutes,25B02@186801|Clostridia,268YG@186813|unclassified Clostridiales	186801|Clostridia	I	Phosphate acyltransferases	plsC	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
PYH3_k127_8135633_5	1185653.A1A1_17010	1.591e-25	110.0	COG1670@1|root,COG1670@2|Bacteria	2|Bacteria	J	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins	-	-	2.3.1.57,2.3.1.82	ko:K00657,ko:K00663	ko00330,ko01100,ko04216,map00330,map01100,map04216	M00135	R01154	RC00004,RC00096	ko00000,ko00001,ko00002,ko01000,ko01504	-	-	-	Acetyltransf_3,Acetyltransf_8
PYH3_k127_8182323_1	311424.DhcVS_809	2.59e-105	344.0	COG0411@1|root,COG0411@2|Bacteria,2G5VI@200795|Chloroflexi,34CWF@301297|Dehalococcoidia	301297|Dehalococcoidia	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
PYH3_k127_8182323_6	1121428.DESHY_60380___1	3.722e-45	171.0	COG2068@1|root,COG2068@2|Bacteria,1UY6E@1239|Firmicutes,249PV@186801|Clostridia,260Y2@186807|Peptococcaceae	186801|Clostridia	S	PFAM HD domain	-	-	-	-	-	-	-	-	-	-	-	-	HD,NTP_transf_3
PYH3_k127_8182323_2	1121451.DESAM_20441	1.044e-72	258.0	COG1975@1|root,COG1975@2|Bacteria,1MXKU@1224|Proteobacteria,42QUY@68525|delta/epsilon subdivisions,2WMVP@28221|Deltaproteobacteria,2M9YK@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	XdhC and CoxI family	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	NTP_transf_3,XdhC_C,XdhC_CoxI
PYH3_k127_8182323_8	1046724.KB889900_gene3205	1.004e-05	51.0	COG0476@1|root,COG0476@2|Bacteria,1MW7H@1224|Proteobacteria,1RPJ3@1236|Gammaproteobacteria,46AKM@72275|Alteromonadaceae	1236|Gammaproteobacteria	H	ThiF family	moeB	-	2.7.7.80,2.8.1.11	ko:K21029,ko:K21147	ko04122,map04122	-	R07459,R07461	RC00043	ko00000,ko00001,ko01000	-	-	-	Prok-JAB,Rhodanese,ThiF,ThiS
PYH3_k127_8182323_0	1205680.CAKO01000008_gene4212	6.295e-172	565.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TWGU@28211|Alphaproteobacteria,2JPGD@204441|Rhodospirillales	204441|Rhodospirillales	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2_2
PYH3_k127_8182323_4	865861.AZSU01000002_gene2692	2.69e-55	198.0	COG2080@1|root,COG2080@2|Bacteria,1V6HE@1239|Firmicutes,24J9B@186801|Clostridia,36K17@31979|Clostridiaceae	186801|Clostridia	C	[2Fe-2S] binding domain	-	-	1.2.5.3	ko:K03518,ko:K13483	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103,R11168	RC00143,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2,Fer2_2
PYH3_k127_8182323_3	1449126.JQKL01000016_gene2869	4.613e-63	229.0	COG1319@1|root,COG1319@2|Bacteria,1TQA5@1239|Firmicutes,248WI@186801|Clostridia,268AT@186813|unclassified Clostridiales	186801|Clostridia	C	CO dehydrogenase flavoprotein C-terminal domain	-	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
PYH3_k127_8182323_9	997350.HMPREF9129_1244	5.146e-05	53.0	COG1716@1|root,COG1716@2|Bacteria,1VF0E@1239|Firmicutes,24PKU@186801|Clostridia,22H5Z@1570339|Peptoniphilaceae	186801|Clostridia	T	FHA domain protein	-	-	-	-	-	-	-	-	-	-	-	-	FHA
PYH3_k127_8182323_5	509191.AEDB02000108_gene1677	1.901e-53	199.0	COG0631@1|root,COG0631@2|Bacteria,1V6K5@1239|Firmicutes,24JD4@186801|Clostridia,3WJ4X@541000|Ruminococcaceae	186801|Clostridia	T	serine threonine protein phosphatase	stp	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C,PP2C_2
PYH3_k127_8182323_7	867845.KI911784_gene4	8.522e-32	133.0	COG0515@1|root,COG0515@2|Bacteria,2G5NM@200795|Chloroflexi,3751T@32061|Chloroflexia	32061|Chloroflexia	KLT	Serine threonine protein kinase	-	-	2.7.11.1	ko:K08884	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
PYH3_k127_8228468_0	552811.Dehly_0054	5.848e-208	666.0	COG0488@1|root,COG0488@2|Bacteria,2G5VD@200795|Chloroflexi,34D9I@301297|Dehalococcoidia	301297|Dehalococcoidia	S	ABC transporter	-	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
PYH3_k127_8228468_3	386456.JQKN01000004_gene198	6.515e-48	175.0	COG0229@1|root,arCOG02815@2157|Archaea,2XXVK@28890|Euryarchaeota	28890|Euryarchaeota	O	COG0229 Conserved domain frequently associated with peptide methionine sulfoxide reductase	msrB	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
PYH3_k127_8228468_1	237368.SCABRO_00243	4.533e-66	238.0	COG0500@1|root,COG0500@2|Bacteria,2IYP3@203682|Planctomycetes	203682|Planctomycetes	Q	O-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Dimerisation2,Methyltransf_2
PYH3_k127_8228468_2	311424.DhcVS_1168	1.651e-55	198.0	COG1970@1|root,COG1970@2|Bacteria,2G9WW@200795|Chloroflexi,34DMM@301297|Dehalococcoidia	301297|Dehalococcoidia	M	Large-conductance mechanosensitive channel, MscL	mscL	-	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
PYH3_k127_8228468_4	445975.COLSTE_02133	1.638e-10	68.0	COG2414@1|root,COG2414@2|Bacteria,2IF1J@201174|Actinobacteria,4CV7Z@84998|Coriobacteriia	84998|Coriobacteriia	C	Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
PYH3_k127_8300422_1	1047013.AQSP01000105_gene1455	4.232e-142	459.0	COG1960@1|root,COG1960@2|Bacteria,2NNRN@2323|unclassified Bacteria	2|Bacteria	I	Dehydrogenase	-	-	1.3.8.1	ko:K00248	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212	-	R01175,R01178,R02661,R03172,R04751	RC00052,RC00068,RC00076,RC00120,RC00148	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
PYH3_k127_8300422_3	697281.Mahau_1318	7.275e-94	314.0	COG2086@1|root,COG2086@2|Bacteria,1TQA0@1239|Firmicutes,247K9@186801|Clostridia,42G21@68295|Thermoanaerobacterales	186801|Clostridia	C	electron transfer flavoprotein	etfB	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
PYH3_k127_8300422_2	1047013.AQSP01000105_gene1453	8.299e-136	442.0	COG2025@1|root,COG2025@2|Bacteria,2NNR6@2323|unclassified Bacteria	2|Bacteria	C	Electron transfer flavoprotein	fixB	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006091,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009055,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0019395,GO:0019752,GO:0022900,GO:0030258,GO:0032787,GO:0033539,GO:0034440,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071704,GO:0072329,GO:0097159,GO:1901265,GO:1901363,GO:1901575	1.3.1.108	ko:K03522,ko:K22432	-	-	-	-	ko00000,ko01000,ko04147	-	-	iAF987.Gmet_2066,iAF987.Gmet_2257	ETF,ETF_alpha,Fer4
PYH3_k127_8300422_6	1385511.N783_10325	1.887e-63	226.0	COG4976@1|root,COG4976@2|Bacteria,1V582@1239|Firmicutes,4HI2P@91061|Bacilli	91061|Bacilli	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
PYH3_k127_8300422_0	264732.Moth_2108	2.916e-150	488.0	COG0147@1|root,COG0147@2|Bacteria,1TQAP@1239|Firmicutes,24946@186801|Clostridia,42FM5@68295|Thermoanaerobacterales	186801|Clostridia	EH	Anthranilate synthase component I, N terminal region	pabB	-	2.6.1.85,4.1.3.27	ko:K01657,ko:K01665,ko:K13950	ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986,R01716	RC00010,RC01418,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind,GATase
PYH3_k127_8300422_4	246194.CHY_1586	5.519e-75	257.0	COG0512@1|root,COG0512@2|Bacteria,1TT9R@1239|Firmicutes,24FR0@186801|Clostridia,42G1H@68295|Thermoanaerobacterales	186801|Clostridia	EH	TIGRFAM glutamine amidotransferase of anthranilate synthase	pabA	-	2.6.1.85,4.1.3.27	ko:K01658,ko:K01664	ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986,R01716	RC00010,RC01418,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS17720	GATase
PYH3_k127_8300422_7	926567.TheveDRAFT_0180	1.388e-58	215.0	COG0115@1|root,COG0115@2|Bacteria,3T9VI@508458|Synergistetes	508458|Synergistetes	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
PYH3_k127_8300422_5	696369.KI912183_gene2375	2.002e-64	226.0	COG0294@1|root,COG0294@2|Bacteria,1TPKT@1239|Firmicutes,248BE@186801|Clostridia,260AI@186807|Peptococcaceae	186801|Clostridia	H	dihydropteroate synthase	folP	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS03115	Pterin_bind
PYH3_k127_8357238_0	706587.Desti_3177	1.419e-158	509.0	COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,42SPZ@68525|delta/epsilon subdivisions,2WIV9@28221|Deltaproteobacteria,2MRHE@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Fer2_4,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
PYH3_k127_8357238_3	335543.Sfum_2946	1.774e-52	188.0	COG3383@1|root,COG3383@2|Bacteria,1NW4J@1224|Proteobacteria,42RH9@68525|delta/epsilon subdivisions,2WNSH@28221|Deltaproteobacteria,2MSIH@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	PFAM molybdopterin oxidoreductase Fe4S4 region	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin
PYH3_k127_8357238_1	706587.Desti_4266	5.259e-67	237.0	COG1143@1|root,COG1143@2|Bacteria,1R412@1224|Proteobacteria,42ND5@68525|delta/epsilon subdivisions,2WIR2@28221|Deltaproteobacteria,2MQSB@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_8357238_2	335543.Sfum_2148	1.743e-57	203.0	COG1908@1|root,COG1908@2|Bacteria,1RCZY@1224|Proteobacteria,437PD@68525|delta/epsilon subdivisions,2X2XQ@28221|Deltaproteobacteria,2MRT7@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	PFAM methyl-viologen-reducing hydrogenase, delta subunit	-	-	1.8.98.5,1.8.98.6	ko:K14127	ko00680,map00680	-	R00019,R11943,R11944	RC00011	ko00000,ko00001,ko01000	-	-	-	FlpD
PYH3_k127_8357238_4	519989.ECTPHS_07137	7.768e-19	91.0	COG1714@1|root,COG1714@2|Bacteria,1N1XF@1224|Proteobacteria,1SDY3@1236|Gammaproteobacteria,1WZR8@135613|Chromatiales	135613|Chromatiales	S	RDD family	-	-	-	-	-	-	-	-	-	-	-	-	RDD
PYH3_k127_8369727_4	391735.Veis_4961	8.677e-74	253.0	COG0318@1|root,COG0318@2|Bacteria,1MUMC@1224|Proteobacteria,2VGZE@28216|Betaproteobacteria	28216|Betaproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
PYH3_k127_8369727_6	477641.MODMU_2390	5.657e-55	202.0	COG0491@1|root,COG0491@2|Bacteria	2|Bacteria	GM	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	-	-	-	ko:K05555	ko01057,ko01130,map01057,map01130	M00778	R09305	-	ko00000,ko00001,ko00002,ko01000,ko01008	-	-	-	Lactamase_B
PYH3_k127_8369727_1	1047013.AQSP01000131_gene1833	1.944e-186	593.0	COG1055@1|root,COG1055@2|Bacteria,2NPE3@2323|unclassified Bacteria	2|Bacteria	P	Arsenical pump membrane protein	arsA	-	-	ko:K03893	-	-	-	-	ko00000,ko02000	2.A.45.1,3.A.4.1	-	-	CitMHS
PYH3_k127_8369727_8	1047013.AQSP01000131_gene1834	5.077e-49	186.0	COG0589@1|root,COG0589@2|Bacteria	2|Bacteria	T	AMP binding	-	-	-	-	-	-	-	-	-	-	-	-	Usp
PYH3_k127_8369727_5	255470.cbdbB16	2.271e-67	234.0	COG1014@1|root,COG1014@2|Bacteria,2G6FV@200795|Chloroflexi,34CU3@301297|Dehalococcoidia	301297|Dehalococcoidia	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	porG	-	1.2.7.1	ko:K00172	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
PYH3_k127_8369727_9	552811.Dehly_0628	4.051e-43	158.0	COG1144@1|root,COG1144@2|Bacteria,2GAVK@200795|Chloroflexi,34DFQ@301297|Dehalococcoidia	301297|Dehalococcoidia	C	4Fe-4S dicluster domain	porD	-	1.2.7.1	ko:K00171	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4
PYH3_k127_8369727_2	311424.DhcVS_632	1.001e-169	542.0	COG0674@1|root,COG0674@2|Bacteria,2G5M1@200795|Chloroflexi,34CZQ@301297|Dehalococcoidia	301297|Dehalococcoidia	C	Pyruvate:ferredoxin oxidoreductase core domain II	porA	-	1.2.7.1	ko:K00169	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
PYH3_k127_8369727_3	255470.cbdbA682	6.682e-128	415.0	COG1013@1|root,COG1013@2|Bacteria,2GBU3@200795|Chloroflexi,34CRD@301297|Dehalococcoidia	301297|Dehalococcoidia	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	porB	-	1.2.7.1	ko:K00170	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
PYH3_k127_8369727_7	311424.DhcVS_634	1.236e-49	183.0	COG1905@1|root,COG1905@2|Bacteria,2G6Q5@200795|Chloroflexi,34CUJ@301297|Dehalococcoidia	301297|Dehalococcoidia	C	Thioredoxin-like [2Fe-2S] ferredoxin	-	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
PYH3_k127_8369727_0	255470.cbdbA684	1.42e-214	674.0	COG1894@1|root,COG1894@2|Bacteria,2G5K9@200795|Chloroflexi,34D48@301297|Dehalococcoidia	301297|Dehalococcoidia	C	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region	-	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
PYH3_k127_8431574_0	552811.Dehly_0494	1.968e-195	620.0	COG0147@1|root,COG0147@2|Bacteria,2G5M7@200795|Chloroflexi,34CJD@301297|Dehalococcoidia	301297|Dehalococcoidia	EH	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
PYH3_k127_8431574_1	1089553.Tph_c26530	3.248e-114	379.0	COG0512@1|root,COG0547@1|root,COG0512@2|Bacteria,COG0547@2|Bacteria,1TP8U@1239|Firmicutes,247WY@186801|Clostridia,42EK5@68295|Thermoanaerobacterales	186801|Clostridia	F	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	-	2.4.2.18,4.1.3.27	ko:K00766,ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R00985,R00986,R01073	RC00010,RC00440,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
PYH3_k127_8431574_2	255470.cbdbA1445	2.665e-83	284.0	COG0134@1|root,COG0134@2|Bacteria,2G6GG@200795|Chloroflexi,34D20@301297|Dehalococcoidia	301297|Dehalococcoidia	E	indole-3-glycerol-phosphate synthase activity	trpC	-	4.1.1.48	ko:K01609	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508	RC00944	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS
PYH3_k127_8600984_0	671143.DAMO_1611	3.916e-134	438.0	COG0303@1|root,COG0303@2|Bacteria,2NP4N@2323|unclassified Bacteria	2|Bacteria	H	MoeA N-terminal region (domain I and II)	moeA	-	2.10.1.1	ko:K03750,ko:K07219	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N,PBP_like
PYH3_k127_8600984_11	552811.Dehly_0641	5.97e-53	191.0	COG0521@1|root,COG0521@2|Bacteria,2G6YJ@200795|Chloroflexi	200795|Chloroflexi	H	May be involved in the biosynthesis of molybdopterin	-	-	2.7.7.75	ko:K03638	ko00790,ko01100,map00790,map01100	-	R09726	RC00002	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth
PYH3_k127_8600984_12	56780.SYN_00663	3.197e-48	179.0	COG1751@1|root,COG1751@2|Bacteria,1RBXI@1224|Proteobacteria,42R3D@68525|delta/epsilon subdivisions,2WMRV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Pyruvate kinase, alpha/beta domain	-	-	-	ko:K09126	-	-	-	-	ko00000	-	-	-	PK_C
PYH3_k127_8600984_6	552811.Dehly_0367	1.131e-79	274.0	COG0061@1|root,COG0061@2|Bacteria,2G6NK@200795|Chloroflexi,34CNH@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
PYH3_k127_8600984_10	552811.Dehly_0366	4.136e-59	209.0	COG1246@1|root,COG1246@2|Bacteria,2G95D@200795|Chloroflexi,34CZ0@301297|Dehalococcoidia	301297|Dehalococcoidia	E	Acetyltransferase (GNAT) domain	-	-	2.3.1.1	ko:K00619	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_1
PYH3_k127_8600984_19	348780.NP_1046A	3.389e-29	125.0	arCOG03919@1|root,arCOG03919@2157|Archaea,2XUDK@28890|Euryarchaeota,23TJR@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	NicO
PYH3_k127_8600984_13	552811.Dehly_0365	9.051e-46	171.0	COG0494@1|root,COG0494@2|Bacteria,2G7A1@200795|Chloroflexi,34CJZ@301297|Dehalococcoidia	301297|Dehalococcoidia	L	NUDIX domain	-	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
PYH3_k127_8600984_16	255470.cbdbA415	6.082e-39	149.0	COG0537@1|root,COG0537@2|Bacteria,2G6VV@200795|Chloroflexi,34DCM@301297|Dehalococcoidia	301297|Dehalococcoidia	FG	Scavenger mRNA decapping enzyme C-term binding	-	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
PYH3_k127_8600984_9	469618.FVAG_01721	2.494e-67	233.0	COG1838@1|root,COG1838@2|Bacteria,378E0@32066|Fusobacteria	32066|Fusobacteria	C	Fumarase C-terminus	-	-	4.2.1.2	ko:K01678	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase_C
PYH3_k127_8600984_1	311424.DhcVS_395	3.226e-110	362.0	COG1951@1|root,COG1951@2|Bacteria,2G6YI@200795|Chloroflexi,34CR9@301297|Dehalococcoidia	301297|Dehalococcoidia	C	Fumarate hydratase (Fumerase)	-	-	4.2.1.2	ko:K01677	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase
PYH3_k127_8600984_2	42256.RradSPS_1262	4.552e-104	348.0	COG0039@1|root,COG0039@2|Bacteria,2GN5S@201174|Actinobacteria	201174|Actinobacteria	C	Belongs to the LDH MDH superfamily. LDH family	mdh	-	1.1.1.27,1.1.1.37	ko:K00016,ko:K00024	ko00010,ko00020,ko00270,ko00620,ko00630,ko00640,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04922,map00010,map00020,map00270,map00620,map00630,map00640,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200,map04922	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R00703,R01000,R03104,R07136	RC00031,RC00044	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Ldh_1_C,Ldh_1_N
PYH3_k127_8600984_17	258594.RPA1451	3.953e-34	143.0	28HWH@1|root,2Z82E@2|Bacteria,1MUF7@1224|Proteobacteria,2TV8Z@28211|Alphaproteobacteria,3JV6A@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_8600984_3	383372.Rcas_2300	4.817e-96	321.0	COG1878@1|root,COG1878@2|Bacteria,2G6VY@200795|Chloroflexi,3777F@32061|Chloroflexia	32061|Chloroflexia	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
PYH3_k127_8600984_18	795359.TOPB45_1126	1.014e-31	132.0	COG1913@1|root,COG1913@2|Bacteria,2GHQB@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	Peptidase family M54	-	-	-	ko:K06974	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M54
PYH3_k127_8600984_8	246197.MXAN_2179	1.422e-69	246.0	COG1250@1|root,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,42M6J@68525|delta/epsilon subdivisions,2WJZQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	PFAM 3-hydroxyacyl-CoA dehydrogenase	-	-	1.1.1.108,1.1.1.157	ko:K00074,ko:K17735	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
PYH3_k127_8600984_5	479434.Sthe_3486	5.344e-84	299.0	COG4867@1|root,COG4867@2|Bacteria,2G8A6@200795|Chloroflexi,27XPF@189775|Thermomicrobia	189775|Thermomicrobia	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_8600984_4	186497.PF0532	1.328e-95	330.0	COG1042@1|root,arCOG01340@2157|Archaea,2XT9G@28890|Euryarchaeota,242UT@183968|Thermococci	183968|Thermococci	C	CoA binding domain	-	-	6.2.1.13	ko:K01905	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	CoA_binding_2,Succ_CoA_lig
PYH3_k127_8600984_14	1229780.BN381_10308	3.828e-45	173.0	COG1277@1|root,COG1277@2|Bacteria,2ID14@201174|Actinobacteria	201174|Actinobacteria	CP	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
PYH3_k127_8600984_7	33876.JNXY01000015_gene7541	7.917e-77	263.0	COG4152@1|root,COG4152@2|Bacteria,2I2U6@201174|Actinobacteria,4DMD2@85008|Micromonosporales	201174|Actinobacteria	S	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	AAA_21,ABC_tran,DUF4162
PYH3_k127_8643705_1	335543.Sfum_2280	4.046e-183	581.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,42MSR@68525|delta/epsilon subdivisions,2WIXG@28221|Deltaproteobacteria,2MRCD@213462|Syntrophobacterales	28221|Deltaproteobacteria	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
PYH3_k127_8643705_2	311424.DhcVS_1180	3.295e-127	415.0	COG0484@1|root,COG0484@2|Bacteria,2G5NV@200795|Chloroflexi,34CYJ@301297|Dehalococcoidia	301297|Dehalococcoidia	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
PYH3_k127_8643705_0	552811.Dehly_0057	2.045e-313	970.0	COG0443@1|root,COG0443@2|Bacteria,2G5U5@200795|Chloroflexi,34D7Q@301297|Dehalococcoidia	301297|Dehalococcoidia	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
PYH3_k127_8643705_5	324602.Caur_2075	2.98e-39	152.0	COG0576@1|root,COG0576@2|Bacteria,2G77I@200795|Chloroflexi,375MV@32061|Chloroflexia	32061|Chloroflexia	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
PYH3_k127_8643705_3	243164.DET1401	2.908e-95	323.0	COG1420@1|root,COG1420@2|Bacteria,2G6AQ@200795|Chloroflexi,34D90@301297|Dehalococcoidia	301297|Dehalococcoidia	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	-	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HrcA
PYH3_k127_8643705_4	255470.cbdbA1363	3.041e-77	265.0	COG2220@1|root,COG2220@2|Bacteria,2G6IQ@200795|Chloroflexi,34D5Y@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
PYH3_k127_8643705_6	1121396.KB892935_gene3861	7.927e-39	162.0	COG2271@1|root,COG2271@2|Bacteria,1QTW2@1224|Proteobacteria,42PZA@68525|delta/epsilon subdivisions,2WJ9A@28221|Deltaproteobacteria,2MKHA@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
PYH3_k127_8643705_7	215803.DB30_3071	1.512e-17	97.0	COG3227@1|root,COG4733@1|root,COG3227@2|Bacteria,COG4733@2|Bacteria,1NNV4@1224|Proteobacteria,42Q3S@68525|delta/epsilon subdivisions,2WYNH@28221|Deltaproteobacteria,2YZIM@29|Myxococcales	28221|Deltaproteobacteria	E	cellulase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_8725318_4	311424.DhcVS_8	6.924e-32	133.0	COG0344@1|root,COG0344@2|Bacteria,2G9EG@200795|Chloroflexi,34D7V@301297|Dehalococcoidia	301297|Dehalococcoidia	I	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP	-	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
PYH3_k127_8725318_3	309801.trd_A0580	3.834e-51	192.0	COG1307@1|root,COG1307@2|Bacteria,2G6PH@200795|Chloroflexi,27YU3@189775|Thermomicrobia	189775|Thermomicrobia	S	Uncharacterised protein, DegV family COG1307	-	-	-	-	-	-	-	-	-	-	-	-	DegV
PYH3_k127_8725318_8	1121938.AUDY01000007_gene2501	8.19e-06	53.0	2DR03@1|root,339MB@2|Bacteria,1VK6Y@1239|Firmicutes,4HR34@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_8725318_2	1121918.ARWE01000001_gene43	9.473e-59	209.0	COG0243@1|root,COG0243@2|Bacteria,1MWPS@1224|Proteobacteria,42QIW@68525|delta/epsilon subdivisions,2WJPY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM Molybdopterin oxidoreductase Fe4S4 region	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,TAT_signal
PYH3_k127_8725318_0	795359.TOPB45_0497	3.929e-288	906.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,2GGUA@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
PYH3_k127_8725318_1	56780.SYN_00604	7.817e-71	250.0	COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,42RMQ@68525|delta/epsilon subdivisions,2WNRZ@28221|Deltaproteobacteria,2MSK1@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Formate dehydrogenase iron-sulfur subunit	fdnH-2	-	-	ko:K00124	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001	-	-	-	Fer4_11,Fer4_4,Form-deh_trans
PYH3_k127_8725318_6	1034347.CAHJ01000032_gene4095	3.788e-29	125.0	COG2864@1|root,COG2864@2|Bacteria,1V757@1239|Firmicutes,4I18J@91061|Bacilli,1ZIX9@1386|Bacillus	91061|Bacilli	C	Prokaryotic cytochrome b561	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB
PYH3_k127_8725318_5	1121423.JONT01000006_gene2421	9.216e-32	136.0	COG3058@1|root,COG3058@2|Bacteria,1VD22@1239|Firmicutes,24P6T@186801|Clostridia,262GU@186807|Peptococcaceae	186801|Clostridia	O	Necessary for formate dehydrogenase activity	-	-	-	ko:K02380	-	-	-	-	ko00000	-	-	-	FdhE
PYH3_k127_8725318_7	330214.NIDE3273	8.591e-10	62.0	COG1826@1|root,COG1826@2|Bacteria,3J1A4@40117|Nitrospirae	40117|Nitrospirae	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	-	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
PYH3_k127_8725318_9	1121448.DGI_2197	0.0001674	47.0	COG1826@1|root,COG1826@2|Bacteria,1NI3F@1224|Proteobacteria,42VIZ@68525|delta/epsilon subdivisions,2WRC5@28221|Deltaproteobacteria,2MDCV@213115|Desulfovibrionales	28221|Deltaproteobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes	tatB	-	-	ko:K03116,ko:K03117	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
PYH3_k127_8743374_4	311424.DhcVS_281	2.027e-49	179.0	COG2001@1|root,COG2001@2|Bacteria,2G6ZC@200795|Chloroflexi,34DCV@301297|Dehalococcoidia	301297|Dehalococcoidia	K	MraZ protein, putative antitoxin-like	mraZ	-	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
PYH3_k127_8743374_2	311424.DhcVS_282	1.54e-115	380.0	COG0275@1|root,COG0275@2|Bacteria,2G658@200795|Chloroflexi,34CIZ@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	mraW	-	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
PYH3_k127_8743374_0	243164.DET0342	1.104e-177	564.0	COG0849@1|root,COG0849@2|Bacteria,2G5V5@200795|Chloroflexi,34CNF@301297|Dehalococcoidia	301297|Dehalococcoidia	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	-	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
PYH3_k127_8743374_1	552811.Dehly_1234	3.654e-160	512.0	COG0206@1|root,COG0206@2|Bacteria,2G5V2@200795|Chloroflexi,34D9X@301297|Dehalococcoidia	301297|Dehalococcoidia	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	-	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
PYH3_k127_8743374_3	311424.DhcVS_140	2.133e-54	193.0	COG2423@1|root,COG2423@2|Bacteria,2G6BQ@200795|Chloroflexi,34CKP@301297|Dehalococcoidia	301297|Dehalococcoidia	C	Catalyzes the NAD( )-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate	arcB	-	1.4.1.1,4.3.1.12	ko:K01750,ko:K19244	ko00250,ko00330,ko00430,ko01100,ko01110,ko01130,ko01230,map00250,map00330,map00430,map01100,map01110,map01130,map01230	-	R00396,R00671	RC00008,RC00354	ko00000,ko00001,ko01000	-	-	-	OCD_Mu_crystall
PYH3_k127_8748557_8	1429046.RR21198_4974	1.539e-13	71.0	COG4689@1|root,COG4689@2|Bacteria	2|Bacteria	Q	acetoacetate decarboxylase activity	adc	-	4.1.1.4	ko:K01574	ko00072,ko00640,ko01100,map00072,map00640,map01100	M00088	R01366	RC00040	ko00000,ko00001,ko00002,ko01000	-	-	-	ADC
PYH3_k127_8748557_0	330084.JNYZ01000015_gene5941	3.607e-145	469.0	COG0183@1|root,COG0183@2|Bacteria,2GKH4@201174|Actinobacteria,4E85G@85010|Pseudonocardiales	201174|Actinobacteria	I	Acetyl-CoA acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Thiolase_C
PYH3_k127_8748557_6	330084.JNYZ01000015_gene5940	8.417e-41	154.0	COG1545@1|root,COG1545@2|Bacteria,2II25@201174|Actinobacteria	201174|Actinobacteria	EGP	nucleic-acid-binding protein containing a Zn-ribbon	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
PYH3_k127_8748557_3	552811.Dehly_1213	5.658e-95	326.0	COG2211@1|root,COG2211@2|Bacteria,2G8SN@200795|Chloroflexi	200795|Chloroflexi	G	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_8748557_4	1499967.BAYZ01000019_gene6264	3.384e-74	257.0	COG0546@1|root,COG0546@2|Bacteria,2NPKQ@2323|unclassified Bacteria	2|Bacteria	S	Haloacid dehalogenase-like hydrolase	gph	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
PYH3_k127_8748557_1	1089553.Tph_c19650	3.828e-124	405.0	COG1071@1|root,COG1071@2|Bacteria,1TQDG@1239|Firmicutes,249HX@186801|Clostridia,42ENM@68295|Thermoanaerobacterales	186801|Clostridia	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	pdhA	-	1.2.4.1	ko:K00161,ko:K21416	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
PYH3_k127_8748557_2	1121472.AQWN01000007_gene1130	5.648e-114	376.0	COG0022@1|root,COG0022@2|Bacteria,1TP3J@1239|Firmicutes,249UD@186801|Clostridia,25ZZC@186807|Peptococcaceae	186801|Clostridia	C	PFAM Transketolase	-	-	-	ko:K21417	-	-	-	-	ko00000,ko01000	-	-	-	Transket_pyr,Transketolase_C
PYH3_k127_8748557_9	339670.Bamb_6376	1.349e-12	79.0	COG2271@1|root,COG2271@2|Bacteria,1MVPS@1224|Proteobacteria,2VKBG@28216|Betaproteobacteria,1K3MX@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Major Facilitator Superfamily	-	-	-	ko:K03535,ko:K08194	-	-	-	-	ko00000,ko02000	2.A.1.14.1,2.A.1.14.7	-	-	MFS_1
PYH3_k127_8748557_7	1379698.RBG1_1C00001G0600	3.388e-35	142.0	COG1670@1|root,COG1670@2|Bacteria,2NPXX@2323|unclassified Bacteria	2|Bacteria	J	Acetyltransferase (GNAT) domain	yokL1	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
PYH3_k127_8748557_5	237368.SCABRO_00409	2.227e-45	171.0	COG1670@1|root,COG1670@2|Bacteria	2|Bacteria	J	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins	BB1022	-	2.3.1.128	ko:K03790	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_3
PYH3_k127_8795562_5	479434.Sthe_3486	1.937e-111	376.0	COG4867@1|root,COG4867@2|Bacteria,2G8A6@200795|Chloroflexi,27XPF@189775|Thermomicrobia	189775|Thermomicrobia	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_8795562_1	1382306.JNIM01000001_gene1826	1.919e-186	593.0	COG1239@1|root,COG1239@2|Bacteria,2G5WJ@200795|Chloroflexi	200795|Chloroflexi	H	introduces a magnesium ion into protoporphyrin IX to yield Mg-protoporphyrin IX	-	-	6.6.1.1	ko:K03404,ko:K03405	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03877	RC01012	ko00000,ko00001,ko01000	-	-	-	AAA_5,Mg_chelatase,VWA_2
PYH3_k127_8795562_11	1280944.HY17_09545	5.781e-39	156.0	COG1024@1|root,COG1024@2|Bacteria,1PK10@1224|Proteobacteria,2TS4M@28211|Alphaproteobacteria,43Y1C@69657|Hyphomonadaceae	28211|Alphaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
PYH3_k127_8795562_26	1382230.ASAP_2763	7.808e-09	61.0	2DPM9@1|root,332MQ@2|Bacteria,1NAPW@1224|Proteobacteria,2UWJH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_8795562_15	1125701.HMPREF1221_00764	5.702e-29	117.0	2DPM9@1|root,332MQ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_8795562_21	1131269.AQVV01000018_gene1940	1.787e-18	87.0	2DPX5@1|root,333S8@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_8795562_25	411466.ACTODO_00001	3.595e-10	61.0	2DMHR@1|root,32RMI@2|Bacteria,2HC0U@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_8795562_18	402777.KB235903_gene430	1.23e-22	98.0	2AFZF@1|root,3163A@2|Bacteria,1GG27@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_8795562_23	1168289.AJKI01000004_gene2926	2.447e-17	83.0	COG2827@1|root,COG2827@2|Bacteria,4P9EH@976|Bacteroidetes,2FZ8T@200643|Bacteroidia	976|Bacteroidetes	L	GIY-YIG catalytic domain	-	-	-	ko:K07461	-	-	-	-	ko00000	-	-	-	GIY-YIG
PYH3_k127_8795562_19	1122927.KB895414_gene5100	5.337e-22	96.0	COG1476@1|root,COG1476@2|Bacteria,1VEGF@1239|Firmicutes,4HWXY@91061|Bacilli,2704G@186822|Paenibacillaceae	91061|Bacilli	K	Helix-turn-helix XRE-family like proteins	-	-	-	ko:K07729	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3
PYH3_k127_8795562_20	1294142.CINTURNW_2002	5.569e-22	99.0	COG0504@1|root,COG0504@2|Bacteria,1V9C7@1239|Firmicutes,250HA@186801|Clostridia,36RPS@31979|Clostridiaceae	186801|Clostridia	F	Glutamine amidotransferase class-I	-	-	-	-	-	-	-	-	-	-	-	-	GATase
PYH3_k127_8795562_13	1173026.Glo7428_3376	3.097e-32	130.0	COG0504@1|root,COG0504@2|Bacteria,1G0ET@1117|Cyanobacteria	1117|Cyanobacteria	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	-	-	-	-	-	-	-	-	-	-	-	-	GATase
PYH3_k127_8795562_10	56107.Cylst_3397	6.345e-44	185.0	COG0656@1|root,COG0656@2|Bacteria,1G6K0@1117|Cyanobacteria,1HNPA@1161|Nostocales	1117|Cyanobacteria	M	Domain of unknown function (DUF4157)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4157,Ntox11
PYH3_k127_8795562_8	1121468.AUBR01000047_gene1866	4.262e-54	198.0	COG3383@1|root,COG3383@2|Bacteria,1TTC3@1239|Firmicutes,24BAV@186801|Clostridia,42I2T@68295|Thermoanaerobacterales	186801|Clostridia	C	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region	-	-	1.17.1.11	ko:K22338	-	-	-	-	ko00000,ko01000	-	-	-	Fer2_4,Fer4,Fer4_21,Fer4_6,Fer4_7,Molybdop_Fe4S4,NADH-G_4Fe-4S_3
PYH3_k127_8795562_14	1410617.JHXH01000005_gene1065	3.636e-29	122.0	COG1905@1|root,COG1905@2|Bacteria,1V737@1239|Firmicutes,24HFB@186801|Clostridia,3WISW@541000|Ruminococcaceae	186801|Clostridia	C	NADH-quinone oxidoreductase, E subunit	nuoE	-	1.12.1.3,1.17.1.11,1.6.5.3	ko:K00334,ko:K18330,ko:K22340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
PYH3_k127_8795562_3	335541.Swol_1018	3.674e-130	427.0	COG1894@1|root,COG1894@2|Bacteria,1TQB0@1239|Firmicutes,2483E@186801|Clostridia	2|Bacteria	C	Respiratory-chain NADH dehydrogenase domain 51 kDa subunit	nqo1	-	1.12.1.3,1.6.5.3	ko:K00335,ko:K18331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB
PYH3_k127_8795562_7	2325.TKV_c19890	3.346e-59	212.0	COG4656@1|root,COG4656@2|Bacteria,1TS9H@1239|Firmicutes,24DQ7@186801|Clostridia,42FJ0@68295|Thermoanaerobacterales	186801|Clostridia	C	Methylene-tetrahydrofolate reductase C terminal	metV	-	-	-	-	-	-	-	-	-	-	-	MTHFR_C
PYH3_k127_8795562_9	880073.Calab_0423	1.239e-53	207.0	COG0642@1|root,COG2205@2|Bacteria	880073.Calab_0423|-	T	PhoQ Sensor	-	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	-
PYH3_k127_8795562_4	1123371.ATXH01000023_gene932	4.326e-118	387.0	COG0457@1|root,COG0685@1|root,COG2069@1|root,COG0457@2|Bacteria,COG0685@2|Bacteria,COG2069@2|Bacteria,2GHER@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	CE	CO dehydrogenase/acetyl-CoA synthase delta subunit	-	-	2.1.1.245	ko:K00194	ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200	M00357,M00377,M00422	R09096,R10219,R10243	RC00004,RC00113,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhD,MTHFR
PYH3_k127_8795562_16	880072.Desac_0830	1.064e-24	109.0	COG0745@1|root,COG0745@2|Bacteria,1PGXZ@1224|Proteobacteria,437JJ@68525|delta/epsilon subdivisions,2X2TK@28221|Deltaproteobacteria,2MSE0@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
PYH3_k127_8795562_17	439235.Dalk_3262	2.242e-23	106.0	COG0745@1|root,COG0745@2|Bacteria,1RINR@1224|Proteobacteria,42T1R@68525|delta/epsilon subdivisions,2WPHY@28221|Deltaproteobacteria,2MK8T@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
PYH3_k127_8795562_24	247490.KSU1_A0074	2.498e-13	76.0	COG0664@1|root,COG0664@2|Bacteria,2J0N9@203682|Planctomycetes	203682|Planctomycetes	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
PYH3_k127_8795562_0	290397.Adeh_2216	1.056e-187	620.0	2DBW6@1|root,2ZBEP@2|Bacteria,1QUH5@1224|Proteobacteria,43CCA@68525|delta/epsilon subdivisions,2X7N7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	TIGRFAM decaheme c-type cytochrome, OmcA MtrC family	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_8795562_6	1379698.RBG1_1C00001G1216	1.113e-91	311.0	COG0407@1|root,COG0407@2|Bacteria,2NPIC@2323|unclassified Bacteria	2|Bacteria	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
PYH3_k127_8795562_2	485913.Krac_10219	1.15e-160	518.0	COG1964@1|root,COG1964@2|Bacteria	2|Bacteria	Q	Radical SAM superfamily	-	-	-	ko:K06937	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Fer4_14,Radical_SAM
PYH3_k127_8795562_12	661478.OP10G_4384	3.972e-36	148.0	COG0682@1|root,COG0682@2|Bacteria	2|Bacteria	M	lipoprotein biosynthetic process	-	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
PYH3_k127_8821988_4	255470.cbdbA779	5.567e-69	241.0	COG5495@1|root,COG5495@2|Bacteria,2G6F3@200795|Chloroflexi,34D9G@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Rossmann-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF2520,Rossmann-like
PYH3_k127_8821988_2	439235.Dalk_3391	2.96e-98	339.0	COG2368@1|root,COG2368@2|Bacteria,1PEQG@1224|Proteobacteria,42NUH@68525|delta/epsilon subdivisions,2WISE@28221|Deltaproteobacteria,2MI4T@213118|Desulfobacterales	28221|Deltaproteobacteria	Q	PFAM 4-hydroxyphenylacetate 3-hydroxylase N terminal	-	-	4.2.1.120,5.3.3.3	ko:K14534	ko00650,ko00720,ko01100,ko01120,ko01200,map00650,map00720,map01100,map01120,map01200	M00374,M00375	R03031,R10782	RC01857,RC03277	ko00000,ko00001,ko00002,ko01000	-	-	-	HpaB,HpaB_N
PYH3_k127_8821988_11	525904.Tter_0505	1.383e-35	141.0	COG0265@1|root,COG0695@1|root,COG0265@2|Bacteria,COG0695@2|Bacteria,2NQ8T@2323|unclassified Bacteria	2|Bacteria	O	Glutaredoxin	grxC	-	3.4.21.107	ko:K03676,ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	Glutaredoxin,PDZ_2
PYH3_k127_8821988_13	324602.Caur_1567	1.201e-11	67.0	COG1143@1|root,COG1143@2|Bacteria,2G9MP@200795|Chloroflexi,377RF@32061|Chloroflexia	32061|Chloroflexia	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
PYH3_k127_8821988_9	671143.DAMO_1690	1.818e-48	184.0	COG0664@1|root,COG0664@2|Bacteria,2NPVK@2323|unclassified Bacteria	2|Bacteria	K	Transcriptional regulator, Crp Fnr family	-	-	-	ko:K10914,ko:K21563	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
PYH3_k127_8821988_0	1125863.JAFN01000001_gene434	7.645e-137	458.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,42PDA@68525|delta/epsilon subdivisions,2WK05@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	NADH flavin oxidoreductase NADH oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN,Pyr_redox_2
PYH3_k127_8821988_5	768706.Desor_0870	2.429e-59	214.0	COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,247PV@186801|Clostridia,260VS@186807|Peptococcaceae	186801|Clostridia	IQ	PFAM short chain dehydrogenase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short,adh_short_C2
PYH3_k127_8821988_7	1449063.JMLS01000002_gene1094	1.692e-53	193.0	COG1247@1|root,COG1247@2|Bacteria,1V6X5@1239|Firmicutes,4HIP1@91061|Bacilli,274WU@186822|Paenibacillaceae	91061|Bacilli	M	Acetyltransferase (GNAT) domain	pat	-	2.3.1.183	ko:K03823	ko00440,ko01130,map00440,map01130	-	R08871,R08938	RC00004,RC00064	ko00000,ko00001,ko01000	-	-	-	Acetyltransf_4
PYH3_k127_8821988_10	768706.Desor_0870	1.379e-42	167.0	COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,247PV@186801|Clostridia,260VS@186807|Peptococcaceae	186801|Clostridia	IQ	PFAM short chain dehydrogenase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short,adh_short_C2
PYH3_k127_8821988_6	1297865.APJD01000009_gene2851	5.961e-59	226.0	COG0747@1|root,COG0747@2|Bacteria,1PFW6@1224|Proteobacteria,2U1GT@28211|Alphaproteobacteria,3JUHW@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Peptide ABC transporter substrate-binding protein	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
PYH3_k127_8821988_3	1429916.X566_03935	1.215e-88	303.0	COG1173@1|root,COG1173@2|Bacteria,1MU26@1224|Proteobacteria,2VF5U@28211|Alphaproteobacteria,3JXA1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
PYH3_k127_8821988_1	1297865.APJD01000009_gene2849	1.281e-100	338.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TR0N@28211|Alphaproteobacteria,3JUIB@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
PYH3_k127_8821988_12	345219.Bcoa_1423	1.13e-29	127.0	COG1309@1|root,COG1309@2|Bacteria,1UZQU@1239|Firmicutes,4HD4B@91061|Bacilli,1ZBMP@1386|Bacillus	91061|Bacilli	K	Transcriptional regulator	kstR2_2	-	-	-	-	-	-	-	-	-	-	-	TetR_N
PYH3_k127_8821988_8	1185876.BN8_01928	5.756e-50	184.0	COG1073@1|root,COG1073@2|Bacteria	2|Bacteria	S	thiolester hydrolase activity	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
PYH3_k127_8838012_0	644282.Deba_2978	2.352e-104	347.0	COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,42MHF@68525|delta/epsilon subdivisions,2WJ1R@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	acoA	-	1.2.4.1	ko:K00161,ko:K21416	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
PYH3_k127_8838012_2	1499968.TCA2_3102	1.339e-48	184.0	COG1028@1|root,COG1028@2|Bacteria,1TSWA@1239|Firmicutes,4HBHR@91061|Bacilli,274QR@186822|Paenibacillaceae	91061|Bacilli	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
PYH3_k127_8838012_1	913865.DOT_0091	2.257e-95	336.0	COG0247@1|root,COG0247@2|Bacteria,1TPG1@1239|Firmicutes,24HJC@186801|Clostridia,264WD@186807|Peptococcaceae	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	1.8.98.1	ko:K08264	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	-	R04540	RC00011	ko00000,ko00001,ko01000	-	-	-	CCG,Fer4_10,Fer4_8
PYH3_k127_8839435_1	439235.Dalk_3105	5.102e-89	298.0	COG0411@1|root,COG0411@2|Bacteria,1R9G9@1224|Proteobacteria,42QH8@68525|delta/epsilon subdivisions,2WKUJ@28221|Deltaproteobacteria,2MNGW@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
PYH3_k127_8839435_0	439235.Dalk_3104	6.99e-212	672.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42M5F@68525|delta/epsilon subdivisions,2WISF@28221|Deltaproteobacteria,2MIAR@213118|Desulfobacterales	28221|Deltaproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
PYH3_k127_8840978_5	742725.HMPREF9450_00262	2.124e-17	83.0	COG1285@1|root,COG1285@2|Bacteria,4NM47@976|Bacteroidetes,2FP38@200643|Bacteroidia,22V3Z@171550|Rikenellaceae	976|Bacteroidetes	S	MgtC family	-	-	-	ko:K07507	-	-	-	-	ko00000,ko02000	9.B.20	-	-	MgtC
PYH3_k127_8840978_0	243164.DET0830	5.338e-228	715.0	COG0119@1|root,COG0119@2|Bacteria,2G5V9@200795|Chloroflexi,34CY8@301297|Dehalococcoidia	301297|Dehalococcoidia	H	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
PYH3_k127_8840978_1	243164.DET0831	4.504e-138	447.0	COG0059@1|root,COG0059@2|Bacteria,2G5NP@200795|Chloroflexi,34D0K@301297|Dehalococcoidia	301297|Dehalococcoidia	H	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
PYH3_k127_8840978_4	1382356.JQMP01000003_gene1440	3.021e-39	158.0	COG0589@1|root,COG0589@2|Bacteria,2G768@200795|Chloroflexi,27Y8A@189775|Thermomicrobia	189775|Thermomicrobia	T	Belongs to the universal stress protein A family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
PYH3_k127_8840978_3	485916.Dtox_0591	1.871e-50	185.0	COG0440@1|root,COG0440@2|Bacteria,1V2AJ@1239|Firmicutes,24HZM@186801|Clostridia,261FW@186807|Peptococcaceae	186801|Clostridia	E	TIGRFAM Acetolactate synthase, small subunit	ilvH	-	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,ACT_5,ALS_ss_C
PYH3_k127_8840978_2	243164.DET0833	9.235e-84	281.0	COG0028@1|root,COG0028@2|Bacteria,2G5Q7@200795|Chloroflexi,34CWN@301297|Dehalococcoidia	301297|Dehalococcoidia	H	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain	ilvB	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
PYH3_k127_8873019_0	243164.DET0947	1.136e-216	688.0	COG4231@1|root,COG4231@2|Bacteria,2G65M@200795|Chloroflexi,34CTB@301297|Dehalococcoidia	301297|Dehalococcoidia	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	iorA	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR_N,TPP_enzyme_C
PYH3_k127_8873019_4	767817.Desgi_1940	5.006e-50	186.0	COG1014@1|root,COG1014@2|Bacteria,1V1DT@1239|Firmicutes,24HIC@186801|Clostridia,261U9@186807|Peptococcaceae	186801|Clostridia	C	PFAM pyruvate ferredoxin flavodoxin oxidoreductase	-	-	1.2.7.8	ko:K00180	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR
PYH3_k127_8873019_1	370438.PTH_1421	3.586e-144	470.0	COG0436@1|root,COG0436@2|Bacteria,1TP36@1239|Firmicutes,248ZV@186801|Clostridia,260AB@186807|Peptococcaceae	186801|Clostridia	E	PFAM Aminotransferase class I and II	yhdR	-	2.6.1.1	ko:K11358	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
PYH3_k127_8873019_2	552811.Dehly_0093	2.31e-88	308.0	COG0617@1|root,COG0617@2|Bacteria,2G8YQ@200795|Chloroflexi,34CU1@301297|Dehalococcoidia	301297|Dehalococcoidia	H	Poly A polymerase head domain	-	-	2.7.7.72	ko:K00974	ko03013,map03013	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	PolyA_pol,PolyA_pol_RNAbd
PYH3_k127_8873019_3	264732.Moth_1867	5.319e-85	297.0	COG0469@1|root,COG0469@2|Bacteria,1TPGG@1239|Firmicutes,2489V@186801|Clostridia,42F1S@68295|Thermoanaerobacterales	186801|Clostridia	G	Belongs to the pyruvate kinase family	pyk	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PEP-utilizers,PK,PK_C
PYH3_k127_8873019_5	644282.Deba_1250	3.335e-09	57.0	COG1592@1|root,COG1592@2|Bacteria,1R9WG@1224|Proteobacteria,42RFX@68525|delta/epsilon subdivisions,2WN92@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
PYH3_k127_8880506_2	552811.Dehly_1209	2.969e-08	55.0	COG0543@1|root,COG0543@2|Bacteria,2GAKZ@200795|Chloroflexi,34CQB@301297|Dehalococcoidia	301297|Dehalococcoidia	C	Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B	-	-	1.18.1.2,1.19.1.1	ko:K00528	-	-	R10159	-	ko00000,ko01000	-	-	-	DHODB_Fe-S_bind
PYH3_k127_8880506_0	1047013.AQSP01000084_gene759	1.618e-218	685.0	COG0493@1|root,COG0493@2|Bacteria,2NNXN@2323|unclassified Bacteria	2|Bacteria	E	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	gltA	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	DHODB_Fe-S_bind,Fer4_20,NAD_binding_1,Pyr_redox_2
PYH3_k127_8880506_1	1382306.JNIM01000001_gene2739	1.094e-143	464.0	COG0249@1|root,COG0249@2|Bacteria,2G5IU@200795|Chloroflexi	200795|Chloroflexi	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
PYH3_k127_8888502_3	243164.DET1251	2.821e-48	179.0	COG0655@1|root,COG0655@2|Bacteria,2G9U1@200795|Chloroflexi,34CYE@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Flavodoxin-like fold	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
PYH3_k127_8888502_2	365528.KB891137_gene386	1.205e-75	269.0	COG1804@1|root,COG1804@2|Bacteria,2GRB0@201174|Actinobacteria,4EUN0@85013|Frankiales	201174|Actinobacteria	C	PFAM L-carnitine dehydratase bile acid-inducible protein F	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
PYH3_k127_8888502_4	1120971.AUCA01000032_gene3028	5.436e-47	180.0	COG1028@1|root,COG1028@2|Bacteria,1UETI@1239|Firmicutes,4HB6V@91061|Bacilli,279MG@186823|Alicyclobacillaceae	91061|Bacilli	IQ	PFAM short-chain dehydrogenase reductase SDR	fabG_4	-	1.1.1.69	ko:K00046	-	-	-	-	ko00000,ko01000	-	-	-	adh_short_C2
PYH3_k127_8888502_0	484770.UFO1_0330	8.618e-147	473.0	COG0019@1|root,COG0019@2|Bacteria,1TPQI@1239|Firmicutes,4H3J8@909932|Negativicutes	909932|Negativicutes	E	carboxynorspermidine decarboxylase	nspC	-	4.1.1.96	ko:K13747	ko00330,ko01100,map00330,map01100	-	R09081,R09082	RC00299	ko00000,ko00001,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
PYH3_k127_8888502_1	1123288.SOV_3c07190	8.605e-130	419.0	COG1748@1|root,COG1748@2|Bacteria,1TQTN@1239|Firmicutes,4H2K0@909932|Negativicutes	909932|Negativicutes	E	Saccharopine dehydrogenase	LYS1	-	1.5.1.7	ko:K00290	ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230	M00030,M00032	R00715	RC00217,RC01532	ko00000,ko00001,ko00002,ko01000	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP
PYH3_k127_8925923_6	456442.Mboo_1037	0.0003267	46.0	COG2006@1|root,arCOG02446@2157|Archaea,2XV9B@28890|Euryarchaeota	28890|Euryarchaeota	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
PYH3_k127_8925923_3	118168.MC7420_528	1.582e-11	67.0	COG2006@1|root,COG2006@2|Bacteria,1G0X0@1117|Cyanobacteria,1HF8Q@1150|Oscillatoriales	1117|Cyanobacteria	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
PYH3_k127_8925923_2	1128421.JAGA01000002_gene993	8.805e-19	96.0	2BHS8@1|root,33DMI@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_4
PYH3_k127_8925923_0	1382306.JNIM01000001_gene857	7.135e-82	282.0	COG1131@1|root,COG1131@2|Bacteria,2G7YX@200795|Chloroflexi	200795|Chloroflexi	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
PYH3_k127_8925923_1	479432.Sros_6613	4.162e-64	229.0	COG4221@1|root,COG4221@2|Bacteria,2ICEF@201174|Actinobacteria,4EMIW@85012|Streptosporangiales	201174|Actinobacteria	S	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
PYH3_k127_8925923_4	1457250.BBMO01000001_gene361	7.847e-09	58.0	COG0667@1|root,arCOG06306@2157|Archaea,2XSXS@28890|Euryarchaeota,23TY2@183963|Halobacteria	183963|Halobacteria	C	oxidoreductases (related to aryl-alcohol dehydrogenases)	mocA	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
PYH3_k127_8925923_5	1035308.AQYY01000001_gene2925	5.871e-06	52.0	COG0667@1|root,COG0667@2|Bacteria,1UHXA@1239|Firmicutes,25E68@186801|Clostridia,267DB@186807|Peptococcaceae	186801|Clostridia	C	Aldo/keto reductase family	-	-	-	ko:K07079	-	-	-	-	ko00000	-	-	-	Aldo_ket_red
PYH3_k127_8957919_0	796606.BMMGA3_06895	5.261e-132	444.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,4HBR0@91061|Bacilli,1ZQ9D@1386|Bacillus	91061|Bacilli	C	NADH:flavin oxidoreductase / NADH oxidase family	-	-	1.3.1.34	ko:K00219	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_FMN,Pyr_redox_2
PYH3_k127_8957919_1	2325.TKV_c18760	3.826e-103	360.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,247V1@186801|Clostridia,42EQG@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM NADH flavin oxidoreductase NADH oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN,Pyr_redox_2
PYH3_k127_8957919_6	1122915.AUGY01000012_gene3839	2.454e-27	128.0	COG0526@1|root,COG0526@2|Bacteria,1VAPY@1239|Firmicutes,4HJN1@91061|Bacilli,26XRF@186822|Paenibacillaceae	91061|Bacilli	CO	Thioredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
PYH3_k127_8957919_2	439235.Dalk_2665	6.744e-58	216.0	COG1960@1|root,COG1960@2|Bacteria,1MUBH@1224|Proteobacteria,42S7G@68525|delta/epsilon subdivisions,2WNH7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
PYH3_k127_8957919_4	13690.CP98_00468	1.303e-35	151.0	COG1960@1|root,COG1960@2|Bacteria,1P8I7@1224|Proteobacteria,2U0AW@28211|Alphaproteobacteria,2K1N3@204457|Sphingomonadales	204457|Sphingomonadales	C	Acyl-CoA dehydrogenase, middle domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
PYH3_k127_8957919_5	1408254.T458_23355	1.66e-29	122.0	COG1024@1|root,COG1024@2|Bacteria,1TQ2V@1239|Firmicutes,4HBT0@91061|Bacilli,26UEW@186822|Paenibacillaceae	91061|Bacilli	I	Belongs to the enoyl-CoA hydratase isomerase family	paaG	-	5.3.3.18	ko:K15866	ko00360,ko01120,map00360,map01120	-	R09837,R09839	RC00004,RC00326,RC02689,RC03003	ko00000,ko00001,ko01000	-	-	-	ECH_1
PYH3_k127_9036259_3	439235.Dalk_0173	1.736e-98	330.0	COG2721@1|root,COG2721@2|Bacteria,1MU9V@1224|Proteobacteria,42M37@68525|delta/epsilon subdivisions,2WK30@28221|Deltaproteobacteria,2MNA5@213118|Desulfobacterales	28221|Deltaproteobacteria	G	D-galactarate dehydratase / Altronate hydrolase, C terminus	-	-	4.2.1.7	ko:K16850	ko00040,ko01100,map00040,map01100	M00631	R01540	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	GD_AH_C
PYH3_k127_9036259_11	1536770.R50345_00880	1.49e-13	76.0	COG2721@1|root,COG2721@2|Bacteria,1TPTX@1239|Firmicutes,4HAQZ@91061|Bacilli,26T2Q@186822|Paenibacillaceae	91061|Bacilli	G	Altronate hydrolase	uxaA	GO:0003674,GO:0003824,GO:0005975,GO:0005996,GO:0006063,GO:0006082,GO:0008150,GO:0008152,GO:0008789,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0019586,GO:0019698,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046365,GO:0046395,GO:0046396,GO:0046397,GO:0071704,GO:0072329,GO:1901575	4.2.1.7	ko:K01685	ko00040,ko01100,map00040,map01100	M00631	R01540	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	GD_AH_C,SAF
PYH3_k127_9036259_4	565033.GACE_1690	1.643e-59	213.0	COG0537@1|root,arCOG00419@2157|Archaea,2XWGT@28890|Euryarchaeota,2466N@183980|Archaeoglobi	183980|Archaeoglobi	F	HIT domain	-	-	2.7.7.53	ko:K19710	ko00230,map00230	-	R00126,R01618	RC00002,RC02753,RC02795	ko00000,ko00001,ko01000	-	-	-	HIT
PYH3_k127_9036259_9	552811.Dehly_0786	1.238e-17	84.0	COG0789@1|root,COG0789@2|Bacteria	2|Bacteria	K	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding	-	-	2.1.1.37	ko:K00558,ko:K13639,ko:K13640	ko00270,ko01100,ko05206,map00270,map01100,map05206	M00035	R04858	RC00003,RC00332	ko00000,ko00001,ko00002,ko01000,ko02048,ko03000,ko03032,ko03036	-	-	-	DNA_methylase,MerR,MerR_1
PYH3_k127_9036259_0	311424.DhcVS_1164	8.405e-203	643.0	COG0029@1|root,COG0029@2|Bacteria,2G5JM@200795|Chloroflexi,34D0E@301297|Dehalococcoidia	301297|Dehalococcoidia	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	-	-	1.4.3.16	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481	RC00006,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
PYH3_k127_9036259_7	552811.Dehly_1114	1.755e-19	93.0	COG1862@1|root,COG1862@2|Bacteria,2GAV4@200795|Chloroflexi,34DET@301297|Dehalococcoidia	301297|Dehalococcoidia	U	Preprotein translocase subunit	yajC	-	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
PYH3_k127_9036259_2	309801.trd_0354	4.32e-127	418.0	COG0621@1|root,COG0621@2|Bacteria,2G5QK@200795|Chloroflexi,27Y2T@189775|Thermomicrobia	189775|Thermomicrobia	H	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
PYH3_k127_9036259_8	679926.Mpet_0418	9.071e-18	86.0	arCOG07681@1|root,arCOG07681@2157|Archaea	2157|Archaea	S	Putative zinc ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	Zn_ribbon_2
PYH3_k127_9036259_1	1121422.AUMW01000014_gene1315	7.289e-134	438.0	COG0183@1|root,COG0183@2|Bacteria,1TT8U@1239|Firmicutes,24FFI@186801|Clostridia	186801|Clostridia	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
PYH3_k127_9036259_6	255470.cbdbA565	7.873e-31	126.0	2DRM1@1|root,33C8J@2|Bacteria,2GATW@200795|Chloroflexi,34DBZ@301297|Dehalococcoidia	301297|Dehalococcoidia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_9036259_5	243164.DET0588	3.945e-38	147.0	COG3877@1|root,COG3877@2|Bacteria,2G734@200795|Chloroflexi,34DDB@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Protein of unknown function (DUF2089)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2089
PYH3_k127_9036259_10	706587.Desti_3898	5.314e-15	79.0	COG4871@1|root,COG4871@2|Bacteria	706587.Desti_3898|-	C	Putative Fe-S cluster	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_904270_3	644282.Deba_0071	1.27e-43	166.0	COG1592@1|root,COG1592@2|Bacteria,1R9WG@1224|Proteobacteria,42RFX@68525|delta/epsilon subdivisions,2WN92@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
PYH3_k127_904270_1	65093.PCC7418_3042	5.771e-88	303.0	COG2006@1|root,COG2006@2|Bacteria,1G0X0@1117|Cyanobacteria	1117|Cyanobacteria	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
PYH3_k127_904270_0	134676.ACPL_7704	1.061e-116	384.0	COG1494@1|root,COG1494@2|Bacteria,2GMQU@201174|Actinobacteria,4DASR@85008|Micromonosporales	201174|Actinobacteria	G	fructose-1,6-bisphosphatase	glpX	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0019318,GO:0019319,GO:0019637,GO:0030145,GO:0030388,GO:0042132,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0046872,GO:0046914,GO:0050308,GO:0071704,GO:1901135,GO:1901576	3.1.3.11	ko:K02446	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00165,M00167	R00762,R04780	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_glpX
PYH3_k127_904270_2	330084.JNYZ01000010_gene6836	6.598e-84	297.0	COG3119@1|root,COG3119@2|Bacteria,2GJ8H@201174|Actinobacteria,4EARD@85010|Pseudonocardiales	201174|Actinobacteria	P	Sulfatase	-	-	3.1.6.6	ko:K01133	-	-	-	-	ko00000,ko01000	-	-	-	Choline_sulf_C,Sulfatase
PYH3_k127_904270_4	1384056.N787_06785	1.102e-05	49.0	COG3318@1|root,COG3318@2|Bacteria,1R4KR@1224|Proteobacteria,1RRDM@1236|Gammaproteobacteria,1X4SM@135614|Xanthomonadales	135614|Xanthomonadales	U	Belongs to the UPF0149 family	-	-	-	ko:K07039	-	-	-	-	ko00000	-	-	-	SEC-C,UPF0149
PYH3_k127_9047838_1	311424.DhcVS_140	6.334e-71	246.0	COG2423@1|root,COG2423@2|Bacteria,2G6BQ@200795|Chloroflexi,34CKP@301297|Dehalococcoidia	301297|Dehalococcoidia	C	Catalyzes the NAD( )-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate	arcB	-	1.4.1.1,4.3.1.12	ko:K01750,ko:K19244	ko00250,ko00330,ko00430,ko01100,ko01110,ko01130,ko01230,map00250,map00330,map00430,map01100,map01110,map01130,map01230	-	R00396,R00671	RC00008,RC00354	ko00000,ko00001,ko01000	-	-	-	OCD_Mu_crystall
PYH3_k127_9047838_2	1100720.ALKN01000052_gene507	7.573e-61	226.0	COG2271@1|root,COG2271@2|Bacteria,1QTW2@1224|Proteobacteria	1224|Proteobacteria	G	Major facilitator Superfamily	MA20_02120	-	-	-	-	-	-	-	-	-	-	-	MFS_1
PYH3_k127_9047838_0	439235.Dalk_5191	6.423e-94	325.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,42NTV@68525|delta/epsilon subdivisions,2WJTP@28221|Deltaproteobacteria,2MIWR@213118|Desulfobacterales	1224|Proteobacteria	C	PFAM CoA-binding domain protein	MA20_15065	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
PYH3_k127_9047838_3	1027273.GZ77_01420	1.648e-37	144.0	2DNW1@1|root,32ZFG@2|Bacteria,1NBSM@1224|Proteobacteria,1S8G5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_9047838_4	1392838.AWNM01000006_gene2355	4.338e-20	96.0	COG2128@1|root,COG2128@2|Bacteria,1R4FX@1224|Proteobacteria,2VRKP@28216|Betaproteobacteria,3T3Z5@506|Alcaligenaceae	28216|Betaproteobacteria	S	Carboxymuconolactone decarboxylase family	-	-	-	-	-	-	-	-	-	-	-	-	CMD
PYH3_k127_9047838_5	316274.Haur_4317	6.764e-11	64.0	COG0841@1|root,COG0841@2|Bacteria,2G68V@200795|Chloroflexi,3756J@32061|Chloroflexia	32061|Chloroflexia	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
PYH3_k127_9057728_9	255470.cbdbA643	1.799e-23	103.0	COG0406@1|root,COG0406@2|Bacteria,2G726@200795|Chloroflexi,34CUV@301297|Dehalococcoidia	301297|Dehalococcoidia	G	Phosphoglycerate mutase family	-	-	3.1.3.73	ko:K02226	ko00860,ko01100,map00860,map01100	M00122	R04594,R11173	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
PYH3_k127_9057728_7	243164.DET0778	1.332e-55	201.0	COG0125@1|root,COG0125@2|Bacteria,2G6G2@200795|Chloroflexi,34D8P@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
PYH3_k127_9057728_4	311424.DhcVS_686	3.096e-70	243.0	COG0164@1|root,COG0164@2|Bacteria,2G6KR@200795|Chloroflexi,34CNZ@301297|Dehalococcoidia	301297|Dehalococcoidia	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	-	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
PYH3_k127_9057728_8	574087.Acear_1657	2.673e-27	115.0	COG0792@1|root,COG0792@2|Bacteria,1VFHQ@1239|Firmicutes,24QNK@186801|Clostridia,3WAYF@53433|Halanaerobiales	186801|Clostridia	L	PFAM Uncharacterised protein family UPF0102	-	-	-	ko:K07460	-	-	-	-	ko00000	-	-	-	UPF0102
PYH3_k127_9057728_3	243164.DET0782	1.216e-70	252.0	COG0352@1|root,COG0352@2|Bacteria,2G6P0@200795|Chloroflexi,34D0T@301297|Dehalococcoidia	301297|Dehalococcoidia	H	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)	thiE	-	2.5.1.3	ko:K00788	ko00730,ko01100,map00730,map01100	M00127	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	TMP-TENI
PYH3_k127_9057728_2	255470.cbdbA759	4.577e-73	251.0	COG2178@1|root,COG2178@2|Bacteria,2G6RW@200795|Chloroflexi,34CS2@301297|Dehalococcoidia	301297|Dehalococcoidia	J	PFAM Translin	-	-	-	ko:K07477	-	-	-	-	ko00000	-	-	-	-
PYH3_k127_9057728_6	696281.Desru_3268	3.259e-64	226.0	COG0491@1|root,COG0491@2|Bacteria,1V6FA@1239|Firmicutes,24JGV@186801|Clostridia,261Y2@186807|Peptococcaceae	186801|Clostridia	P	PFAM Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
PYH3_k127_9057728_0	552811.Dehly_1005	1.945e-183	578.0	COG1980@1|root,COG1980@2|Bacteria,2G63P@200795|Chloroflexi,34CJF@301297|Dehalococcoidia	301297|Dehalococcoidia	G	Catalyzes two subsequent steps in gluconeogenesis the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P)	fbp	-	3.1.3.11,4.1.2.13	ko:K01622	ko00010,ko00030,ko00051,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00003	R00762,R01068,R01070,R02568,R04780	RC00017,RC00438,RC00439	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_3
PYH3_k127_9057728_5	243164.DET1226	4.719e-70	242.0	COG0127@1|root,COG0127@2|Bacteria,2G6GK@200795|Chloroflexi,34CM3@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	-	-	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
PYH3_k127_9057728_1	243164.DET1227	1.055e-148	479.0	COG0592@1|root,COG0592@2|Bacteria,2G641@200795|Chloroflexi,34CUN@301297|Dehalococcoidia	301297|Dehalococcoidia	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	dnaN	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
PYH3_k127_9057728_10	331113.SNE_A18580	0.0005303	44.0	COG3070@1|root,COG3070@2|Bacteria	2|Bacteria	K	positive regulation of type IV pilus biogenesis	-	-	-	ko:K07343	-	-	-	-	ko00000	-	-	-	TfoX_N
PYH3_k127_9057784_0	926692.AZYG01000085_gene833	1.159e-63	220.0	COG0415@1|root,COG0415@2|Bacteria,1UDZT@1239|Firmicutes,249FJ@186801|Clostridia,3WAHJ@53433|Halanaerobiales	186801|Clostridia	L	PFAM DNA photolyase	phr	-	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase
PYH3_k127_9057784_3	665571.STHERM_c16540	4.389e-05	46.0	2DBF0@1|root,2Z8VT@2|Bacteria,2J5RW@203691|Spirochaetes	203691|Spirochaetes	S	3-oxo-5-alpha-steroid 4-dehydrogenase	-	-	1.3.1.22	ko:K12343	ko00140,map00140	-	R02208,R02497,R08954,R10242	RC00145	ko00000,ko00001,ko01000	-	-	-	Steroid_dh
PYH3_k127_9057784_2	1501230.ET33_18710	9.559e-57	208.0	COG3173@1|root,COG3173@2|Bacteria,1V511@1239|Firmicutes,4ISNU@91061|Bacilli,2775A@186822|Paenibacillaceae	91061|Bacilli	S	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
PYH3_k127_9057784_1	880072.Desac_2148	2.682e-61	228.0	COG0034@1|root,COG0034@2|Bacteria,1R7JX@1224|Proteobacteria,42MAC@68525|delta/epsilon subdivisions,2WKFD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Glutamine phosphoribosylpyrophosphate amidotransferase	-	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_7
PYH3_k127_9057784_4	1500306.JQLA01000002_gene1854	0.0009222	42.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TR7Q@28211|Alphaproteobacteria,4B81P@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	carnitine dehydratase	caiB	GO:0003674,GO:0003824,GO:0008410,GO:0016740,GO:0016782,GO:0047369	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
PYH3_k127_9193144_1	404589.Anae109_1810	3.523e-71	246.0	COG2197@1|root,COG2197@2|Bacteria,1R9GN@1224|Proteobacteria,42PU2@68525|delta/epsilon subdivisions,2X60T@28221|Deltaproteobacteria,2Z327@29|Myxococcales	28221|Deltaproteobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
PYH3_k127_9193144_2	926550.CLDAP_25550	5.388e-55	213.0	COG2203@1|root,COG4585@1|root,COG5002@1|root,COG2203@2|Bacteria,COG4585@2|Bacteria,COG5002@2|Bacteria,2G8PE@200795|Chloroflexi	200795|Chloroflexi	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
PYH3_k127_9193144_0	552811.Dehly_0134	2.354e-82	283.0	COG1526@1|root,COG1526@2|Bacteria,2G74E@200795|Chloroflexi	200795|Chloroflexi	C	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH	fdhD	-	-	ko:K02379	-	-	-	-	ko00000	-	-	-	FdhD-NarQ
PYH3_k127_9193144_3	552811.Dehly_0247	7.562e-06	48.0	COG0309@1|root,COG0309@2|Bacteria,2G7TM@200795|Chloroflexi,34CX4@301297|Dehalococcoidia	301297|Dehalococcoidia	O	AIR synthase related protein, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AIRS,AIRS_C
PYH3_k127_9326459_3	311424.DhcVS_1203	2.023e-60	219.0	COG0037@1|root,COG0037@2|Bacteria,2G6AD@200795|Chloroflexi,34CWT@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3,TilS_C
PYH3_k127_9326459_5	397291.C804_00124	2.232e-37	145.0	COG0139@1|root,COG0139@2|Bacteria	2|Bacteria	E	phosphoribosyl-AMP cyclohydrolase activity	hisI	-	3.5.4.19,3.6.1.31	ko:K01496,ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035,R04037	RC00002,RC01055	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-CH
PYH3_k127_9326459_2	195522.BD01_0213	1.03e-66	234.0	COG1042@1|root,arCOG01338@2157|Archaea,2XXCA@28890|Euryarchaeota,2435P@183968|Thermococci	183968|Thermococci	C	ATP-grasp domain	-	-	6.2.1.13	ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5
PYH3_k127_9326459_6	573063.Metin_0820	1.222e-34	139.0	COG0655@1|root,arCOG02573@2157|Archaea,2XVMU@28890|Euryarchaeota,23QEP@183939|Methanococci	183939|Methanococci	S	PFAM NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
PYH3_k127_9326459_1	696281.Desru_2615	1.005e-66	239.0	COG0778@1|root,COG0778@2|Bacteria,1UZC3@1239|Firmicutes,24BKG@186801|Clostridia,264TH@186807|Peptococcaceae	186801|Clostridia	C	PFAM Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	TM1586_NiRdase
PYH3_k127_9326459_0	1499967.BAYZ01000195_gene3082	2.339e-106	355.0	COG1453@1|root,COG1453@2|Bacteria	2|Bacteria	S	Aldo/keto reductase family	-	-	-	ko:K07079	-	-	-	-	ko00000	-	-	-	Aldo_ket_red,Fer4_17
PYH3_k127_9326459_8	439235.Dalk_3239	2.497e-31	131.0	COG0484@1|root,COG0484@2|Bacteria,1MUZ4@1224|Proteobacteria,42NBY@68525|delta/epsilon subdivisions,2WJV2@28221|Deltaproteobacteria,2MIIH@213118|Desulfobacterales	28221|Deltaproteobacteria	O	heat shock protein DnaJ domain protein	-	-	-	ko:K03686,ko:K05516	-	-	-	-	ko00000,ko03029,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C
PYH3_k127_9326459_7	255470.cbdbA1428	2.103e-34	138.0	COG0350@1|root,COG0350@2|Bacteria,2G6TT@200795|Chloroflexi,34DBJ@301297|Dehalococcoidia	301297|Dehalococcoidia	L	6-O-methylguanine DNA methyltransferase, DNA binding domain	ogt	-	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1
PYH3_k127_9326459_4	255470.cbdbA1432	1.111e-59	211.0	COG2003@1|root,COG2003@2|Bacteria,2GAJE@200795|Chloroflexi,34CJ0@301297|Dehalococcoidia	301297|Dehalococcoidia	E	RadC-like JAB domain	-	-	-	ko:K03630	-	-	-	-	ko00000	-	-	-	RadC
PYH3_k127_93852_3	311424.DhcVS_291	7.18e-52	202.0	COG3103@1|root,COG4991@2|Bacteria,2G9F6@200795|Chloroflexi,34D2H@301297|Dehalococcoidia	301297|Dehalococcoidia	T	sh3 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	TIG
PYH3_k127_93852_5	311424.DhcVS_1226	6.686e-32	133.0	COG0344@1|root,COG0344@2|Bacteria,2GAX8@200795|Chloroflexi,34DIK@301297|Dehalococcoidia	301297|Dehalococcoidia	I	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP	-	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
PYH3_k127_93852_1	1121324.CLIT_13c01530	1.905e-103	344.0	COG3958@1|root,COG3958@2|Bacteria,1V0K5@1239|Firmicutes,24914@186801|Clostridia,25QQ5@186804|Peptostreptococcaceae	186801|Clostridia	G	Transketolase	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
PYH3_k127_93852_0	477974.Daud_2078	1.631e-108	357.0	COG3959@1|root,COG3959@2|Bacteria,1TT51@1239|Firmicutes,247IK@186801|Clostridia,2607I@186807|Peptococcaceae	186801|Clostridia	G	PFAM Transketolase, thiamine diphosphate binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
PYH3_k127_93852_2	1343739.PAP_05870	7.729e-90	315.0	COG1042@1|root,arCOG01340@2157|Archaea,2XT9G@28890|Euryarchaeota,243Q6@183968|Thermococci	183968|Thermococci	C	CoA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding_2,Succ_CoA_lig
PYH3_k127_93852_4	370438.PTH_2212	3.08e-51	188.0	COG2110@1|root,COG2755@1|root,COG2110@2|Bacteria,COG2755@2|Bacteria,1VDE2@1239|Firmicutes,24N6X@186801|Clostridia,262J2@186807|Peptococcaceae	186801|Clostridia	E	PFAM GDSL-like Lipase Acylhydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
PYH3_k127_93852_6	1382356.JQMP01000001_gene1055	5.878e-31	134.0	28HQ3@1|root,2Z7XW@2|Bacteria,2G9Q4@200795|Chloroflexi,27XYJ@189775|Thermomicrobia	189775|Thermomicrobia	S	Protein of unknown function (DUF2851)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2851
PYH3_k127_944729_2	690850.Desaf_1800	1.467e-69	240.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,43BJY@68525|delta/epsilon subdivisions,2WIWD@28221|Deltaproteobacteria,2M9AS@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Formate dehydrogenase, alpha subunit	fdnG-2	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal
PYH3_k127_944729_5	1117379.BABA_10916	1.964e-55	201.0	COG0243@1|root,COG0243@2|Bacteria,1V2XY@1239|Firmicutes,4HWR9@91061|Bacilli,1ZB6J@1386|Bacillus	91061|Bacilli	C	COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,TAT_signal
PYH3_k127_944729_1	485913.Krac_4978	1.581e-91	316.0	COG0517@1|root,COG1994@1|root,COG0517@2|Bacteria,COG1994@2|Bacteria,2G5WG@200795|Chloroflexi	200795|Chloroflexi	S	Belongs to the peptidase M50B family	-	-	-	-	-	-	-	-	-	-	-	-	CBS,Peptidase_M50
PYH3_k127_944729_0	311424.DhcVS_1210	3.119e-243	761.0	COG0459@1|root,COG0459@2|Bacteria,2G65N@200795|Chloroflexi,34CMY@301297|Dehalococcoidia	301297|Dehalococcoidia	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groEL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
PYH3_k127_944729_8	309801.trd_1301	8.199e-37	141.0	COG0234@1|root,COG0234@2|Bacteria,2G6WW@200795|Chloroflexi,27YJ2@189775|Thermomicrobia	189775|Thermomicrobia	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	-	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
PYH3_k127_944729_4	871963.Desdi_1500	4.894e-59	222.0	COG2271@1|root,COG2271@2|Bacteria,1TRHT@1239|Firmicutes,24C2D@186801|Clostridia,263AG@186807|Peptococcaceae	186801|Clostridia	G	Major Facilitator	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
PYH3_k127_944729_7	113395.AXAI01000031_gene615	1.289e-43	174.0	COG2271@1|root,COG2271@2|Bacteria,1QTW2@1224|Proteobacteria,2U07Z@28211|Alphaproteobacteria,3JR8H@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Major Facilitator Superfamily	MA20_02120	-	-	-	-	-	-	-	-	-	-	-	MFS_1
PYH3_k127_944729_3	706587.Desti_5196	4.209e-62	229.0	COG2271@1|root,COG2271@2|Bacteria,1QTW2@1224|Proteobacteria	1224|Proteobacteria	G	Major facilitator Superfamily	MA20_02120	-	-	-	-	-	-	-	-	-	-	-	MFS_1
PYH3_k127_944729_6	552811.Dehly_0962	9.686e-48	173.0	COG0498@1|root,COG0498@2|Bacteria,2G66Y@200795|Chloroflexi,34D2S@301297|Dehalococcoidia	301297|Dehalococcoidia	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	thrC	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
PYH3_k127_955871_0	1089553.Tph_c28000	3.946e-56	212.0	COG0407@1|root,COG0407@2|Bacteria,1TPQ6@1239|Firmicutes,25DH9@186801|Clostridia	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
PYH3_k127_955871_1	1089553.Tph_c28000	4.758e-48	178.0	COG0407@1|root,COG0407@2|Bacteria,1TPQ6@1239|Firmicutes,25DH9@186801|Clostridia	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
PYH3_k127_9578750_16	255470.cbdbA1009	3.989e-19	92.0	COG0265@1|root,COG0265@2|Bacteria,2GAJH@200795|Chloroflexi,34CVE@301297|Dehalococcoidia	301297|Dehalococcoidia	M	Trypsin-like serine protease	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin_2
PYH3_k127_9578750_1	1047013.AQSP01000141_gene116	2.84e-203	641.0	COG1350@1|root,COG1350@2|Bacteria,2NNY3@2323|unclassified Bacteria	2|Bacteria	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K01696,ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
PYH3_k127_9578750_2	311424.DhcVS_300	1.853e-181	580.0	28MN1@1|root,2ZAXN@2|Bacteria,2G6CU@200795|Chloroflexi,34D42@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Terminase-like family	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_9578750_11	255470.cbdbA297	1.199e-36	142.0	2BQ9G@1|root,32J4A@2|Bacteria,2GAU8@200795|Chloroflexi,34DCZ@301297|Dehalococcoidia	301297|Dehalococcoidia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_9578750_14	243164.DET0359	2.687e-25	114.0	COG1579@1|root,COG1579@2|Bacteria,2G775@200795|Chloroflexi,34D9U@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Zn-ribbon protein possibly nucleic acid-binding	-	-	-	ko:K07164	-	-	-	-	ko00000	-	-	-	zf-RING_7
PYH3_k127_9578750_12	994479.GL877878_gene2561	4.207e-33	133.0	COG0328@1|root,COG0406@1|root,COG0328@2|Bacteria,COG0406@2|Bacteria,2GJ9R@201174|Actinobacteria,4E04U@85010|Pseudonocardiales	201174|Actinobacteria	GL	phosphoglycerate mutase	rnhA	GO:0003674,GO:0003676,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005488,GO:0006139,GO:0006401,GO:0006725,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016070,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016891,GO:0016893,GO:0017144,GO:0018130,GO:0019438,GO:0019439,GO:0032296,GO:0033013,GO:0033014,GO:0034641,GO:0034655,GO:0042364,GO:0042578,GO:0043170,GO:0043755,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0046700,GO:0051186,GO:0051188,GO:0071667,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576	3.1.26.4,3.1.3.73	ko:K02226,ko:K22316	ko00860,ko01100,ko03030,map00860,map01100,map03030	M00122	R04594,R11173	RC00017	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	His_Phos_1,RVT_3
PYH3_k127_9578750_5	255470.cbdbA783	6.041e-144	467.0	COG0477@1|root,COG2814@2|Bacteria,2G65U@200795|Chloroflexi,34D0C@301297|Dehalococcoidia	301297|Dehalococcoidia	EGP	MFS/sugar transport protein	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
PYH3_k127_9578750_10	909663.KI867150_gene1506	2.65e-51	199.0	COG1775@1|root,COG1775@2|Bacteria,1NKED@1224|Proteobacteria,42NFZ@68525|delta/epsilon subdivisions,2WMBX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	PFAM 2-hydroxyglutaryl-CoA dehydratase, D-component	-	-	-	-	-	-	-	-	-	-	-	-	HGD-D
PYH3_k127_9578750_3	255470.cbdbA525	4.383e-163	526.0	COG0568@1|root,COG0568@2|Bacteria,2G5W3@200795|Chloroflexi,34D2Y@301297|Dehalococcoidia	301297|Dehalococcoidia	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	rpoD	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
PYH3_k127_9578750_4	243164.DET0552	2.098e-156	512.0	COG0358@1|root,COG0358@2|Bacteria,2G65X@200795|Chloroflexi,34CVJ@301297|Dehalococcoidia	301297|Dehalococcoidia	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,Toprim_2,Toprim_N,zf-CHC2
PYH3_k127_9578750_6	243164.DET0553	3.029e-128	419.0	COG0232@1|root,COG0232@2|Bacteria,2G5VZ@200795|Chloroflexi,34CSV@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Phosphohydrolase-associated domain	-	-	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	-	HD,HD_assoc
PYH3_k127_9578750_0	552811.Dehly_0790	8.968e-295	922.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2G6K4@200795|Chloroflexi,34CQ2@301297|Dehalococcoidia	301297|Dehalococcoidia	H	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	ppsA	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
PYH3_k127_9578750_8	1226325.HMPREF1548_00599	1.434e-68	247.0	COG5012@1|root,COG5012@2|Bacteria,1V82H@1239|Firmicutes,25NHT@186801|Clostridia,36SAV@31979|Clostridiaceae	186801|Clostridia	S	cobalamin binding	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_9578750_7	439235.Dalk_5191	3.31e-104	356.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,42NTV@68525|delta/epsilon subdivisions,2WJTP@28221|Deltaproteobacteria,2MIWR@213118|Desulfobacterales	1224|Proteobacteria	C	PFAM CoA-binding domain protein	MA20_15065	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
PYH3_k127_9578750_15	994573.T472_0205565	2.2e-21	96.0	2C539@1|root,33HA4@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_9578750_9	1038859.AXAU01000002_gene328	2.667e-53	197.0	COG1028@1|root,COG1028@2|Bacteria,1MUFX@1224|Proteobacteria,2TRWN@28211|Alphaproteobacteria,3JSZZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	MA20_17615	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
PYH3_k127_9578750_13	278957.ABEA03000203_gene2742	4.666e-31	128.0	COG3467@1|root,COG3467@2|Bacteria,46WZ0@74201|Verrucomicrobia,3K94J@414999|Opitutae	414999|Opitutae	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Pyridox_ox_2
PYH3_k127_9578750_17	1254432.SCE1572_35515	2.271e-16	83.0	COG5649@1|root,COG5649@2|Bacteria	2|Bacteria	E	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
PYH3_k127_9605379_7	1343739.PAP_02640	4.091e-34	139.0	arCOG07677@1|root,arCOG07677@2157|Archaea,2XWVM@28890|Euryarchaeota,244MD@183968|Thermococci	183968|Thermococci	S	Possible catecholamine-binding domain present in a variety of eukaryotic proteins.	-	-	-	-	-	-	-	-	-	-	-	-	DOMON
PYH3_k127_9605379_5	868131.MSWAN_2227	2.059e-39	149.0	COG2146@1|root,arCOG02852@2157|Archaea,2XUZH@28890|Euryarchaeota	28890|Euryarchaeota	P	COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases	-	-	-	-	-	-	-	-	-	-	-	-	Rieske,Rieske_2
PYH3_k127_9605379_6	1232410.KI421416_gene2675	1.87e-35	137.0	COG0599@1|root,COG0599@2|Bacteria,1N2ZQ@1224|Proteobacteria,42VDR@68525|delta/epsilon subdivisions,2WRKS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM Carboxymuconolactone decarboxylase	-	-	-	-	-	-	-	-	-	-	-	-	CMD
PYH3_k127_9605379_1	243231.GSU1158	4.532e-94	311.0	COG0605@1|root,COG0605@2|Bacteria,1R4Z3@1224|Proteobacteria,42QV7@68525|delta/epsilon subdivisions,2WMPC@28221|Deltaproteobacteria,43VQC@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Iron/manganese superoxide dismutases, C-terminal domain	sodA	-	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
PYH3_k127_9605379_0	264732.Moth_1905	2.061e-99	335.0	COG0620@1|root,COG0620@2|Bacteria,1V08M@1239|Firmicutes,24BMV@186801|Clostridia	186801|Clostridia	E	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_9605379_2	290397.Adeh_2002	4.91e-62	226.0	COG3005@1|root,COG3005@2|Bacteria,1QYG3@1224|Proteobacteria,43CC8@68525|delta/epsilon subdivisions,2X7N4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Cytochrome c3	-	-	-	-	-	-	-	-	-	-	-	-	Paired_CXXCH_1
PYH3_k127_9605379_3	290397.Adeh_2001	1.108e-46	177.0	COG2864@1|root,COG2864@2|Bacteria,1NJEJ@1224|Proteobacteria,42NQM@68525|delta/epsilon subdivisions,2WK76@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	denitrification pathway	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB
PYH3_k127_9605379_8	387631.Asulf_00796	7.103e-18	85.0	COG2835@1|root,arCOG04124@2157|Archaea,2XZRS@28890|Euryarchaeota,247DV@183980|Archaeoglobi	183980|Archaeoglobi	S	Belongs to the UPF0434 family	-	-	-	-	-	-	-	-	-	-	-	-	Trm112p
PYH3_k127_9605379_4	255470.cbdbA1699	9.194e-40	151.0	COG0720@1|root,COG0720@2|Bacteria,2G7B6@200795|Chloroflexi,34DDV@301297|Dehalococcoidia	301297|Dehalococcoidia	H	6-pyruvoyl tetrahydropterin synthase	-	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
PYH3_k127_9613956_2	1047013.AQSP01000120_gene951	7.477e-39	147.0	COG4104@1|root,COG4104@2|Bacteria	2|Bacteria	T	PAAR repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	PAAR_motif
PYH3_k127_9613956_1	1382306.JNIM01000001_gene3322	1.762e-48	176.0	COG3628@1|root,COG3628@2|Bacteria,2G7CQ@200795|Chloroflexi	200795|Chloroflexi	S	PFAM GPW gp25 family protein	-	-	-	ko:K06903	-	-	-	-	ko00000	-	-	-	GPW_gp25
PYH3_k127_9613956_0	1382306.JNIM01000001_gene3321	2.824e-161	531.0	COG3299@1|root,COG3299@2|Bacteria,2G84U@200795|Chloroflexi	200795|Chloroflexi	S	Baseplate J-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Baseplate_J
PYH3_k127_9613956_3	56107.Cylst_1936	1.681e-26	115.0	COG4385@1|root,COG4385@2|Bacteria,1G2G6@1117|Cyanobacteria,1HMIY@1161|Nostocales	1117|Cyanobacteria	S	PFAM Phage tail protein (Tail_P2_I)	-	-	-	-	-	-	-	-	-	-	-	-	Tail_P2_I
PYH3_k127_9701765_0	479434.Sthe_1821	2.246e-98	332.0	COG0820@1|root,COG0820@2|Bacteria,2G5SD@200795|Chloroflexi,27XRH@189775|Thermomicrobia	189775|Thermomicrobia	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	-	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Radical_SAM
PYH3_k127_9701765_3	529709.PYCH_12630	6.04e-47	177.0	COG1208@1|root,arCOG00666@2157|Archaea,2XUA6@28890|Euryarchaeota,2431F@183968|Thermococci	183968|Thermococci	M	Nucleotidyl transferase	-	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
PYH3_k127_9701765_1	319225.Plut_0242	1.224e-69	251.0	COG1215@1|root,COG1215@2|Bacteria,1FDR6@1090|Chlorobi	1090|Chlorobi	M	PFAM glycosyl transferase family 2	-	-	-	ko:K14597	ko00906,map00906	-	R07544,R07546	RC00262	ko00000,ko00001	-	-	-	Glyco_tranf_2_3,Glycos_transf_2
PYH3_k127_9701765_4	926569.ANT_13450	4.025e-28	121.0	COG0344@1|root,COG0344@2|Bacteria,2G8ZF@200795|Chloroflexi	200795|Chloroflexi	I	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP	-	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
PYH3_k127_9701765_10	330779.Saci_1853	0.0001907	54.0	arCOG06052@1|root,arCOG06052@2157|Archaea	2157|Archaea	-	-	-	-	3.4.23.42	ko:K01385	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	CARDB
PYH3_k127_9701765_8	882083.SacmaDRAFT_3182	8.717e-07	57.0	COG0716@1|root,COG0716@2|Bacteria,2IQZD@201174|Actinobacteria,4E5JA@85010|Pseudonocardiales	201174|Actinobacteria	C	PFAM Flavodoxin	-	-	1.6.5.2	ko:K03809	ko00130,ko01110,map00130,map01110	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	Flavodoxin_1,Flavodoxin_5
PYH3_k127_9701765_7	1163617.SCD_n01153	3.182e-08	65.0	COG2391@1|root,COG2391@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
PYH3_k127_9701765_2	795359.TOPB45_1238	1.118e-50	190.0	COG0063@1|root,COG0063@2|Bacteria,2GHG3@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	G	Carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	Carb_kinase
PYH3_k127_9701765_9	644282.Deba_0012	2.467e-06	50.0	arCOG05017@1|root,3015V@2|Bacteria,1RDNC@1224|Proteobacteria,42RJ5@68525|delta/epsilon subdivisions,2WNJP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Protein of unknown function (DUF3343)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3343
PYH3_k127_9701765_5	1121445.ATUZ01000019_gene2209	2.989e-22	101.0	arCOG05017@1|root,3015V@2|Bacteria,1RDNC@1224|Proteobacteria,42RJ5@68525|delta/epsilon subdivisions,2WNJP@28221|Deltaproteobacteria,2MBMV@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF3343)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3343
PYH3_k127_9701765_6	644282.Deba_2487	2.313e-17	89.0	COG2020@1|root,COG2020@2|Bacteria,1PK64@1224|Proteobacteria,432NT@68525|delta/epsilon subdivisions,2WX82@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	PFAM Isoprenylcysteine carboxyl methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_971_3	243164.DET0729	1.422e-87	292.0	COG1894@1|root,COG1894@2|Bacteria,2G5K9@200795|Chloroflexi,34D48@301297|Dehalococcoidia	301297|Dehalococcoidia	C	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region	-	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
PYH3_k127_971_5	255470.cbdbA685	9.137e-77	264.0	COG3383@1|root,COG3383@2|Bacteria,2GAS8@200795|Chloroflexi,34D7W@301297|Dehalococcoidia	301297|Dehalococcoidia	C	2Fe-2S iron-sulfur cluster binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer2_4,Fer4
PYH3_k127_971_7	1089553.Tph_c22670	1.095e-30	126.0	COG0680@1|root,COG0680@2|Bacteria,1V7KQ@1239|Firmicutes,24IHW@186801|Clostridia,42HCG@68295|Thermoanaerobacterales	186801|Clostridia	C	hydrogenase maturation protease	-	-	-	ko:K03605	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	HycI
PYH3_k127_971_0	646529.Desaci_2270	6.948e-192	621.0	COG0685@1|root,COG0685@2|Bacteria,1W739@1239|Firmicutes,25NME@186801|Clostridia,260RW@186807|Peptococcaceae	186801|Clostridia	E	Methylenetetrahydrofolate reductase	-	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR,MTHFR_C
PYH3_k127_971_8	62977.ACIAD0787	6.942e-07	58.0	COG0745@1|root,COG0745@2|Bacteria,1RI9T@1224|Proteobacteria,1S5UT@1236|Gammaproteobacteria,3NN3I@468|Moraxellaceae	1236|Gammaproteobacteria	KT	Response regulator receiver domain	pilH	-	-	ko:K02658	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko02022,ko02035,ko02044	-	-	-	Response_reg
PYH3_k127_971_6	1121382.JQKG01000017_gene1858	4.043e-65	229.0	COG2197@1|root,COG2197@2|Bacteria,1WI4W@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	T	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
PYH3_k127_971_4	555088.DealDRAFT_1801	7.185e-82	297.0	COG4585@1|root,COG4585@2|Bacteria,1TQI3@1239|Firmicutes,249R9@186801|Clostridia	186801|Clostridia	T	Histidine kinase	-	-	2.7.13.3	ko:K07777	ko02020,map02020	M00478	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA_3,PAS
PYH3_k127_971_2	926550.CLDAP_05570	1.583e-136	448.0	COG1921@1|root,COG1921@2|Bacteria,2G5VV@200795|Chloroflexi	200795|Chloroflexi	H	Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis	selA	-	2.9.1.1	ko:K01042	ko00450,ko00970,map00450,map00970	-	R08219	RC01246	ko00000,ko00001,ko01000	-	-	-	Se-cys_synth_N,SelA
PYH3_k127_971_1	309801.trd_0508	1.153e-183	592.0	COG3276@1|root,COG3276@2|Bacteria,2G5JX@200795|Chloroflexi,27XRW@189775|Thermomicrobia	189775|Thermomicrobia	J	Elongation factor SelB, winged helix	-	-	-	ko:K03833	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,SelB-wing_2,SelB-wing_3
PYH3_k127_9739357_2	1313172.YM304_13600	1.37e-52	200.0	COG3178@1|root,COG3178@2|Bacteria,2GN8T@201174|Actinobacteria	201174|Actinobacteria	S	Ecdysteroid kinase	-	-	-	-	-	-	-	-	-	-	-	-	EcKinase
PYH3_k127_9739357_3	469381.Dpep_2388	2.518e-49	185.0	COG0496@1|root,COG0496@2|Bacteria,3T9W9@508458|Synergistetes	508458|Synergistetes	S	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates	surE	-	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	SurE
PYH3_k127_9739357_0	552811.Dehly_1315	1.073e-124	408.0	COG2008@1|root,COG2008@2|Bacteria,2G5XG@200795|Chloroflexi,34CXV@301297|Dehalococcoidia	301297|Dehalococcoidia	E	Beta-eliminating lyase	gly1	-	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	-	R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
PYH3_k127_9739357_1	1094980.Mpsy_1982	3.046e-73	259.0	arCOG02487@1|root,arCOG02487@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4129
## 1980 queries scanned
## Total time (seconds): 74.89891195297241
## Rate: 26.44 q/s