## Thu Oct 17 12:59:50 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/Potential_rubisco_autotrophic/PYH3_bin.61.fa -m mmseqs --itype genome -o PYH3_bin.61 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/all_bins_1385/PYH3_bin.61 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
PYH3_k127_1027398_0	224325.AF_0907	6.126e-80	282.0	COG0477@1|root,arCOG00130@2157|Archaea,2Y8EJ@28890|Euryarchaeota	28890|Euryarchaeota	G	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
PYH3_k127_1027398_9	410359.Pcal_0622	5.329e-06	52.0	arCOG04057@1|root,arCOG04057@2157|Archaea	2157|Archaea	J	Belongs to the eukaryotic ribosomal protein eL38 family	rpl38e	-	-	ko:K02923	ko03010,map03010	M00177	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L38e
PYH3_k127_1027398_10	186497.PF0543	4.694e-05	49.0	COG1977@1|root,arCOG00536@2157|Archaea,2XZ69@28890|Euryarchaeota,244I1@183968|Thermococci	183968|Thermococci	H	ThiS family	-	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
PYH3_k127_1027398_4	1151117.AJLF01000001_gene1091	2.184e-23	102.0	COG1581@1|root,arCOG01753@2157|Archaea,2XZH4@28890|Euryarchaeota,244BC@183968|Thermococci	183968|Thermococci	K	Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes	albA	-	-	ko:K03622	-	-	-	-	ko00000	-	-	-	Alba
PYH3_k127_1027398_8	933801.Ahos_0792	7.223e-09	59.0	COG1383@1|root,arCOG01885@2157|Archaea,2XRGM@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eS17 family	rps17e	GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02962	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17e
PYH3_k127_1027398_6	1183377.Py04_1713	1.533e-14	76.0	COG2036@1|root,arCOG02144@2157|Archaea,2XZYK@28890|Euryarchaeota,244HP@183968|Thermococci	183968|Thermococci	L	Binds and compact DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils. Increases the resistance of DNA to thermal denaturation	-	-	-	-	-	-	-	-	-	-	-	-	CBFD_NFYB_HMF
PYH3_k127_1027398_2	399550.Smar_0791	9.904e-33	136.0	COG1936@1|root,arCOG01038@2157|Archaea,2XQII@28889|Crenarchaeota	28889|Crenarchaeota	F	Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates	-	-	2.7.4.3	ko:K18532	ko00230,ko01100,ko01110,ko01130,ko03008,map00230,map01100,map01110,map01130,map03008	M00049	R00127,R01547	RC00002	ko00000,ko00001,ko00002,ko01000,ko03009	-	-	-	AAA_18
PYH3_k127_1027398_3	1459636.NTE_03306	2.43e-25	111.0	COG1958@1|root,arCOG00999@2157|Archaea	2157|Archaea	K	PFAM Like-Sm ribonucleoprotein, core	-	-	-	-	-	-	-	-	-	-	-	-	LSM,Lsm_C,SM-ATX
PYH3_k127_1027398_1	877455.Metbo_0211	8.123e-38	151.0	COG2047@1|root,arCOG00348@2157|Archaea,2XSX4@28890|Euryarchaeota,23P1D@183925|Methanobacteria	183925|Methanobacteria	S	PAC2 family	-	-	-	ko:K07159	-	-	-	-	ko00000	-	-	-	PAC2
PYH3_k127_1027398_7	1154757.Q5C_00210	1.824e-10	64.0	COG1942@1|root,COG1942@2|Bacteria,1VKD5@1239|Firmicutes,4HRBS@91061|Bacilli,4AY5W@81850|Leuconostocaceae	91061|Bacilli	G	protein, 4-oxalocrotonate tautomerase homolog	dmpI	GO:0003674,GO:0003824,GO:0006725,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0044237	5.3.2.6	ko:K01821	ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220	M00569	R03966,R05389	RC01040,RC01355	ko00000,ko00001,ko00002,ko01000	-	-	-	Tautomerase
PYH3_k127_1027398_5	572478.Vdis_1864	2.14e-18	87.0	COG0343@1|root,arCOG00989@2157|Archaea,2XPSY@28889|Crenarchaeota	28889|Crenarchaeota	J	Exchanges the guanine residue with 7-cyano-7- deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D- loop) of archaeal tRNAs	tgtA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046116,GO:0046483,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.2.48	ko:K18779	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TGT
PYH3_k127_106661_9	1365176.N186_04385	2.156e-28	117.0	COG0142@1|root,arCOG01726@2157|Archaea,2XPZM@28889|Crenarchaeota	28889|Crenarchaeota	H	Belongs to the FPP GGPP synthase family	fgs	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13787	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
PYH3_k127_106661_5	439481.Aboo_0423	4.475e-48	183.0	COG1608@1|root,arCOG00860@2157|Archaea,2XSUI@28890|Euryarchaeota,3F2Y8@33867|unclassified Euryarchaeota	28890|Euryarchaeota	I	Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids	argB1	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006629,GO:0006720,GO:0006721,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016114,GO:0016740,GO:0016772,GO:0016776,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0102043,GO:1901576	2.7.4.26	ko:K06981	ko00900,ko01110,ko01130,map00900,map01110,map01130	-	R10093	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
PYH3_k127_106661_12	768679.TTX_1480	1.725e-14	77.0	COG4352@1|root,arCOG01013@2157|Archaea,2XRIE@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eL13 family	rpl13e	-	-	ko:K02873	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13e,Ribosomal_L15e
PYH3_k127_106661_7	591019.Shell_1617	3.707e-41	156.0	COG1632@1|root,arCOG04209@2157|Archaea,2XPQ8@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eL15 family	rpl15e	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02877	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L15e
PYH3_k127_106661_10	195522.BD01_0968	2.218e-17	85.0	COG4003@1|root,arCOG05763@2157|Archaea,2Y3NV@28890|Euryarchaeota,2446V@183968|Thermococci	183968|Thermococci	S	Uncharacterized protein conserved in archaea (DUF2095)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2095
PYH3_k127_106661_1	420247.Msm_0655	5.508e-111	372.0	COG1208@1|root,arCOG00666@2157|Archaea,2XT8U@28890|Euryarchaeota,23NRH@183925|Methanobacteria	183925|Methanobacteria	M	Bacterial transferase hexapeptide repeat	-	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
PYH3_k127_106661_2	272844.PAB1666	2.284e-107	364.0	COG1109@1|root,arCOG00767@2157|Archaea,2XT1X@28890|Euryarchaeota,242T7@183968|Thermococci	183968|Thermococci	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	-	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
PYH3_k127_106661_4	768672.Desfe_1430	4.257e-52	191.0	COG1890@1|root,arCOG04186@2157|Archaea,2XPNX@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eS1 family	rps3ae	GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576	-	ko:K02984	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S3Ae
PYH3_k127_106661_0	523845.AQXV01000055_gene15	2.236e-113	385.0	COG0172@1|root,arCOG00403@2157|Archaea,2XUK2@28890|Euryarchaeota,23QBS@183939|Methanococci	183939|Methanococci	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2b
PYH3_k127_106661_3	673860.AciM339_1443	3.202e-92	321.0	COG0608@1|root,arCOG00427@2157|Archaea,2XT8Y@28890|Euryarchaeota,3F2FV@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	DHHA1 domain	recJ	-	-	ko:K07463	-	-	-	-	ko00000	-	-	-	DHHA1
PYH3_k127_106661_6	1449063.JMLS01000003_gene1831	5.516e-45	171.0	COG2032@1|root,COG2032@2|Bacteria,1V3HM@1239|Firmicutes,4HHM6@91061|Bacilli,26YB1@186822|Paenibacillaceae	91061|Bacilli	P	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	yojM_2	-	1.15.1.1	ko:K04565	ko04146,ko04213,ko05014,ko05016,ko05020,map04146,map04213,map05014,map05016,map05020	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Cu
PYH3_k127_106661_8	572478.Vdis_1974	9.158e-41	156.0	COG0184@1|root,arCOG04185@2157|Archaea,2XQ88@28889|Crenarchaeota	28889|Crenarchaeota	J	ribosomal protein S15	rps15	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13_N,Ribosomal_S15
PYH3_k127_106661_11	224324.aq_951	2.944e-16	79.0	COG0077@1|root,COG1605@1|root,COG0077@2|Bacteria,COG1605@2|Bacteria,2G3JS@200783|Aquificae	200783|Aquificae	E	Prephenate dehydratase	pheA	GO:0003674,GO:0003824,GO:0004664,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006558,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009094,GO:0009095,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0019438,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902221,GO:1902223	4.2.1.51,5.4.99.5	ko:K14170	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R00691,R01373,R01715	RC00360,RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,CM_2,PDT
PYH3_k127_1334560_2	368408.Tpen_0750	6.489e-53	192.0	COG1793@1|root,arCOG01347@2157|Archaea,2XPV8@28889|Crenarchaeota	28889|Crenarchaeota	L	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair	lig	GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016874,GO:0016886,GO:0022616,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360,GO:1901576	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N
PYH3_k127_1334560_4	1123373.ATXI01000024_gene116	1.721e-50	185.0	COG0778@1|root,COG0778@2|Bacteria,2GHHZ@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	C	Putative TM nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
PYH3_k127_1334560_0	1041930.Mtc_0381	2.638e-146	473.0	COG0269@1|root,arCOG00103@2157|Archaea,2XUYW@28890|Euryarchaeota,2N9CN@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin	fae-hps	-	4.1.2.43,4.2.1.147	ko:K13812	ko00030,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00680,map01100,map01120,map01200,map01230	M00345,M00580	R05338,R08058	RC00421,RC00422,RC01583,RC01795	ko00000,ko00001,ko00002,ko01000	-	-	-	Fae,OMPdecase
PYH3_k127_1334560_1	192952.MM_0471	7.308e-56	207.0	COG0122@1|root,arCOG00464@2157|Archaea,2XU5Y@28890|Euryarchaeota,2N9M2@224756|Methanomicrobia	224756|Methanomicrobia	L	8-oxoguanine DNA glycosylase domain protein	-	-	4.2.99.18	ko:K03660	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD,OGG_N
PYH3_k127_1334560_9	368408.Tpen_0482	3.531e-09	67.0	arCOG03727@1|root,arCOG03727@2157|Archaea	2157|Archaea	-	-	-	-	2.7.7.7	ko:K02339	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	Mrr_cat,NERD
PYH3_k127_1334560_3	1131266.ARWQ01000015_gene750	8.014e-52	198.0	COG0750@1|root,arCOG00609@2157|Archaea,41S8V@651137|Thaumarchaeota	651137|Thaumarchaeota	M	Peptidase family M50	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
PYH3_k127_1334560_5	444157.Tneu_0025	7.276e-50	183.0	COG0456@1|root,arCOG00833@2157|Archaea,2XQJH@28889|Crenarchaeota	28889|Crenarchaeota	S	TIGRFAM ribosomal-protein-alanine acetyltransferase	-	GO:0003674,GO:0003824,GO:0004596,GO:0005575,GO:0005622,GO:0005623,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0031248,GO:0031365,GO:0032991,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051604,GO:0071704,GO:1901564,GO:1902493,GO:1902494,GO:1990234	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
PYH3_k127_1334560_7	374847.Kcr_0527	4.835e-20	101.0	COG0517@1|root,arCOG00606@2157|Archaea	2157|Archaea	I	CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
PYH3_k127_1334560_8	436308.Nmar_0932	1.907e-16	83.0	COG1758@1|root,arCOG01268@2157|Archaea,41ST9@651137|Thaumarchaeota	651137|Thaumarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoK	-	-	ko:K03014	ko00230,ko00240,ko01100,ko03020,ko04623,ko05016,ko05169,map00230,map00240,map01100,map03020,map04623,map05016,map05169	M00180,M00181,M00182	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
PYH3_k127_1334560_6	1071085.KK033114_gene518	4.971e-35	138.0	COG0459@1|root,arCOG01257@2157|Archaea,2XUDQ@28890|Euryarchaeota,23SSR@183963|Halobacteria	183963|Halobacteria	O	Belongs to the TCP-1 chaperonin family	ths1	-	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
PYH3_k127_1349961_1	868131.MSWAN_1950	6.632e-79	280.0	COG0595@1|root,arCOG00547@2157|Archaea,2XTIB@28890|Euryarchaeota,23PHA@183925|Methanobacteria	183925|Methanobacteria	J	PFAM RNA-metabolising metallo-beta-lactamase	-	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B_2,RMMBL
PYH3_k127_1349961_6	221288.JH992901_gene3767	3.503e-35	147.0	COG0823@1|root,COG0823@2|Bacteria,1G8I3@1117|Cyanobacteria	1117|Cyanobacteria	U	WD40-like Beta Propeller Repeat	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40
PYH3_k127_1349961_12	365046.Rta_12870	3.857e-10	62.0	COG1942@1|root,COG1942@2|Bacteria,1N8I6@1224|Proteobacteria,2VW8C@28216|Betaproteobacteria,4AFEI@80864|Comamonadaceae	28216|Betaproteobacteria	G	4-oxalocrotonate tautomerase	-	-	5.3.2.6	ko:K01821	ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220	M00569	R03966,R05389	RC01040,RC01355	ko00000,ko00001,ko00002,ko01000	-	-	-	Tautomerase
PYH3_k127_1349961_7	1380408.AVGH01000005_gene2565	2.559e-24	108.0	COG0607@1|root,COG0607@2|Bacteria,1VES3@1239|Firmicutes,4HQN2@91061|Bacilli,21X2R@150247|Anoxybacillus	91061|Bacilli	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
PYH3_k127_1349961_2	192952.MM_0633	9.751e-72	258.0	arCOG05009@1|root,arCOG05009@2157|Archaea,2XZTV@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554
PYH3_k127_1349961_0	1291050.JAGE01000002_gene3569	2.339e-139	460.0	COG1233@1|root,COG1233@2|Bacteria,1TS4A@1239|Firmicutes,249K1@186801|Clostridia,3WHBS@541000|Ruminococcaceae	186801|Clostridia	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
PYH3_k127_1349961_5	410358.Mlab_1687	2.159e-38	150.0	arCOG04820@1|root,arCOG04820@2157|Archaea,2XX4W@28890|Euryarchaeota	28890|Euryarchaeota	T	PFAM SOUL heme-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SOUL
PYH3_k127_1349961_3	243274.THEMA_05620	2.099e-54	201.0	COG1028@1|root,COG1028@2|Bacteria,2GCDH@200918|Thermotogae	200918|Thermotogae	IQ	Short-chain dehydrogenase reductase SDR	fabG	GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
PYH3_k127_1349961_4	868131.MSWAN_0446	9.789e-43	161.0	COG0456@1|root,arCOG00833@2157|Archaea	2157|Archaea	C	PFAM GCN5-related N-acetyltransferase	-	-	2.3.1.1,2.3.1.178	ko:K06718,ko:K22477	ko00220,ko00260,ko01100,ko01120,ko01210,ko01230,map00220,map00260,map01100,map01120,map01210,map01230	M00028,M00033	R00259,R06978	RC00004,RC00064,RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_1
PYH3_k127_1349961_10	164757.Mjls_4463	1.553e-15	83.0	COG3467@1|root,COG3467@2|Bacteria,2IK9H@201174|Actinobacteria,239SR@1762|Mycobacteriaceae	201174|Actinobacteria	S	pyridoxamine 5'-phosphate	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
PYH3_k127_1349961_13	566466.NOR53_2807	4.478e-07	61.0	arCOG09742@1|root,2ZBGR@2|Bacteria,1R9H3@1224|Proteobacteria,1S2HM@1236|Gammaproteobacteria,1J9ND@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_1349961_8	877455.Metbo_0294	2.366e-22	102.0	COG0517@1|root,arCOG00606@2157|Archaea,2XX11@28890|Euryarchaeota,23PS9@183925|Methanobacteria	183925|Methanobacteria	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
PYH3_k127_1349961_11	926690.KE386573_gene340	2.021e-12	73.0	COG1917@1|root,arCOG02999@2157|Archaea,2XZ2S@28890|Euryarchaeota,23X15@183963|Halobacteria	183963|Halobacteria	S	conserved protein, contains double-stranded beta-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
PYH3_k127_1349961_15	1051632.TPY_3783	0.0004395	45.0	COG1814@1|root,COG1814@2|Bacteria,1V011@1239|Firmicutes	1239|Firmicutes	S	VIT family	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
PYH3_k127_1399485_66	868131.MSWAN_2069	2.297e-17	83.0	COG3269@1|root,arCOG01641@2157|Archaea,2Y1N9@28890|Euryarchaeota	28890|Euryarchaeota	S	PFAM Deoxyribonuclease rho motif-related TRAM	-	-	-	-	-	-	-	-	-	-	-	-	TRAM
PYH3_k127_1399485_14	1121403.AUCV01000039_gene4362	9.036e-87	296.0	COG0492@1|root,COG0492@2|Bacteria,1R82E@1224|Proteobacteria,42PSM@68525|delta/epsilon subdivisions,2WJYX@28221|Deltaproteobacteria,2MN1E@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_3
PYH3_k127_1399485_74	224325.AF_0529	1.311e-07	58.0	arCOG07522@1|root,arCOG07522@2157|Archaea,2Y1I3@28890|Euryarchaeota,247FV@183980|Archaeoglobi	183980|Archaeoglobi	K	Transcriptional regulator, TrmB	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_1399485_40	1459636.NTE_00462	4.179e-44	170.0	COG0455@1|root,arCOG00589@2157|Archaea	2157|Archaea	D	COG0455 ATPases involved in chromosome partitioning	-	-	-	ko:K03496,ko:K03609	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31,CbiA
PYH3_k127_1399485_79	479433.Caci_1445	0.0002994	52.0	COG3325@1|root,COG3325@2|Bacteria,2I2ZC@201174|Actinobacteria	201174|Actinobacteria	G	Glycosyl hydrolases family 18	-	-	3.2.1.14	ko:K01183	ko00520,ko01100,map00520,map01100	-	R01206,R02334	RC00467	ko00000,ko00001,ko01000	-	GH18	-	CBM_4_9,Glyco_hydro_18
PYH3_k127_1399485_31	1499967.BAYZ01000177_gene5729	4.793e-49	185.0	COG0207@1|root,COG0207@2|Bacteria	2|Bacteria	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis	thyA	-	2.1.1.45	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylat_synt
PYH3_k127_1399485_65	333138.LQ50_21220	1.329e-17	95.0	COG0726@1|root,COG1215@1|root,COG3858@1|root,COG0726@2|Bacteria,COG1215@2|Bacteria,COG3858@2|Bacteria,1TR2P@1239|Firmicutes,4HAQN@91061|Bacilli,1ZS1A@1386|Bacillus	91061|Bacilli	M	Glycosyl transferase family group 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_18,Glycos_transf_2,Polysacc_deac_1
PYH3_k127_1399485_13	572478.Vdis_0369	1.551e-89	302.0	COG1830@1|root,arCOG04044@2157|Archaea,2XPUI@28889|Crenarchaeota	28889|Crenarchaeota	G	PFAM deoxyribose-phosphate aldolase phospho-2-dehydro-3-deoxyheptonate aldolase	fba	-	4.1.2.13	ko:K11645	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	DeoC
PYH3_k127_1399485_21	457570.Nther_2188	2.378e-75	273.0	COG4805@1|root,COG4805@2|Bacteria	2|Bacteria	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
PYH3_k127_1399485_67	485913.Krac_1305	1.197e-16	83.0	COG1308@1|root,COG1308@2|Bacteria	2|Bacteria	K	protein transport	-	-	-	-	-	-	-	-	-	-	-	-	DUF4342
PYH3_k127_1399485_3	374847.Kcr_0867	4.579e-152	493.0	COG0351@1|root,arCOG00020@2157|Archaea	2157|Archaea	H	Phosphomethylpyrimidine kinase	thiD	-	2.5.1.3,2.7.1.49,2.7.4.7	ko:K00941,ko:K21219,ko:K21220	ko00730,ko01100,map00730,map01100	M00127	R03223,R03471,R04509,R10712	RC00002,RC00017,RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	Phos_pyr_kin,ThiP_synth
PYH3_k127_1399485_11	357808.RoseRS_2771	7.603e-125	413.0	COG1457@1|root,COG1457@2|Bacteria,2G9KC@200795|Chloroflexi,376PN@32061|Chloroflexia	32061|Chloroflexia	F	Permease for cytosine/purines, uracil, thiamine, allantoin	-	-	-	-	-	-	-	-	-	-	-	-	Transp_cyt_pur
PYH3_k127_1399485_75	573063.Metin_0350	9.376e-06	56.0	arCOG06562@1|root,arCOG06562@2157|Archaea,2Y5QT@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_1399485_63	1121403.AUCV01000015_gene4723	1.068e-17	91.0	COG1341@1|root,COG1341@2|Bacteria	2|Bacteria	S	polynucleotide 5'-hydroxyl-kinase activity	-	-	-	ko:K06947	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	CLP1_P
PYH3_k127_1399485_47	469381.Dpep_1537	9.205e-37	144.0	COG4732@1|root,COG4732@2|Bacteria,3TB6R@508458|Synergistetes	508458|Synergistetes	S	TIGRFAM thiW protein	thiW	-	-	-	-	-	-	-	-	-	-	-	ThiW
PYH3_k127_1399485_78	1245469.S58_68130	0.0002447	49.0	COG2010@1|root,COG3391@1|root,COG2010@2|Bacteria,COG3391@2|Bacteria,1PYK3@1224|Proteobacteria,2TVHI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Cytochrome D1 heme domain	nirN	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_D1,Cytochrome_CBB3
PYH3_k127_1399485_25	374847.Kcr_0368	1.367e-59	218.0	COG0281@1|root,arCOG01331@2157|Archaea	2157|Archaea	C	Zn-dependent protease with chaperone function	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
PYH3_k127_1399485_80	368407.Memar_1960	0.0004734	47.0	COG1460@1|root,arCOG01016@2157|Archaea,2XXZX@28890|Euryarchaeota,2N9UM@224756|Methanomicrobia	224756|Methanomicrobia	K	PFAM RNA polymerase Rpb4	rpoF	-	2.7.7.6	ko:K03051	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb4
PYH3_k127_1399485_59	273063.STK_04590	1.655e-25	108.0	COG2139@1|root,arCOG04129@2157|Archaea,2XQR1@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eL21 family	rpl21e	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02889	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21e
PYH3_k127_1399485_4	1183377.Py04_1586	3.498e-149	484.0	COG0541@1|root,arCOG01228@2157|Archaea,2XTWX@28890|Euryarchaeota,24377@183968|Thermococci	183968|Thermococci	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	srp54	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
PYH3_k127_1399485_16	1220534.B655_2454	2.229e-81	281.0	COG1899@1|root,arCOG04142@2157|Archaea,2XSTD@28890|Euryarchaeota,23NS4@183925|Methanobacteria	183925|Methanobacteria	O	Deoxyhypusine synthase	dys	-	2.5.1.46	ko:K00809	-	-	-	-	ko00000,ko01000	-	-	-	DS
PYH3_k127_1399485_43	1365176.N186_03075	8.597e-41	156.0	COG0231@1|root,arCOG04277@2157|Archaea,2XQCW@28889|Crenarchaeota	28889|Crenarchaeota	J	Functions by promoting the formation of the first peptide bond	eif5a	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03263	-	-	-	-	ko00000,ko03012	-	-	-	EFP_N,eIF-5a
PYH3_k127_1399485_37	868131.MSWAN_0315	7.543e-46	176.0	COG0061@1|root,arCOG01348@2157|Archaea,2XTP6@28890|Euryarchaeota,23NXW@183925|Methanobacteria	183925|Methanobacteria	F	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	Inositol_P,NAD_kinase
PYH3_k127_1399485_64	439481.Aboo_0130	1.098e-17	90.0	COG1439@1|root,arCOG00721@2157|Archaea,2XWH2@28890|Euryarchaeota,3F2SW@33867|unclassified Euryarchaeota	28890|Euryarchaeota	V	PIN domain of ribonuclease	nob1	GO:0000469,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005575,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0022613,GO:0030490,GO:0030684,GO:0030688,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1990904	-	ko:K07060	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PIN_6
PYH3_k127_1399485_28	186497.PF1862	1.528e-57	207.0	COG1491@1|root,arCOG04130@2157|Archaea,2XXAI@28890|Euryarchaeota,242KI@183968|Thermococci	183968|Thermococci	J	Protein of unknown function (DUF655)	-	-	-	ko:K07572	-	-	-	-	ko00000	-	-	-	DUF655
PYH3_k127_1399485_32	304371.MCP_0726	9.286e-49	184.0	COG0030@1|root,arCOG04131@2157|Archaea,2XU1Q@28890|Euryarchaeota,2N9HP@224756|Methanomicrobia	224756|Methanomicrobia	J	Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
PYH3_k127_1399485_46	304371.MCP_0730	6.73e-37	148.0	COG0565@1|root,arCOG01018@2157|Archaea,2XUIY@28890|Euryarchaeota,2N9I5@224756|Methanomicrobia	224756|Methanomicrobia	J	TIGRFAM RNA methyltransferase, TrmH family, group 1	-	-	-	ko:K02533	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
PYH3_k127_1399485_39	523845.AQXV01000053_gene665	3.209e-44	166.0	COG0197@1|root,arCOG04113@2157|Archaea,2XTHT@28890|Euryarchaeota,23QNQ@183939|Methanococci	183939|Methanococci	J	Belongs to the universal ribosomal protein uL16 family	rpl10e	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02866	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
PYH3_k127_1399485_22	877455.Metbo_0198	3.114e-68	244.0	COG1736@1|root,arCOG04112@2157|Archaea,2XSY5@28890|Euryarchaeota,23NUP@183925|Methanobacteria	183925|Methanobacteria	J	Diphthamide	-	-	2.5.1.108	ko:K07561	-	-	R10455	RC00021,RC03180	ko00000,ko01000,ko03012	-	-	-	Diphthamide_syn
PYH3_k127_1399485_38	1183377.Py04_0367	1.074e-44	170.0	COG2263@1|root,arCOG00910@2157|Archaea,2XU4P@28890|Euryarchaeota,24393@183968|Thermococci	183968|Thermococci	J	Conserved hypothetical protein 95	-	-	-	ko:K07579	-	-	-	-	ko00000	-	-	-	MTS,PrmA
PYH3_k127_1399485_56	192952.MM_1879	3.657e-27	119.0	COG1096@1|root,arCOG00676@2157|Archaea,2XYYA@28890|Euryarchaeota,2N9T0@224756|Methanomicrobia	224756|Methanomicrobia	J	Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs	csl4	-	-	ko:K07573	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	ECR1_N,EXOSC1
PYH3_k127_1399485_70	386456.JQKN01000012_gene988	7.626e-15	78.0	COG1761@1|root,arCOG04111@2157|Archaea,2XYYQ@28890|Euryarchaeota,23P9S@183925|Methanobacteria	183925|Methanobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoL	-	2.7.7.6	ko:K03056	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_L_2
PYH3_k127_1399485_61	69014.TK1166	1.677e-19	93.0	arCOG05836@1|root,arCOG05836@2157|Archaea,2Y48U@28890|Euryarchaeota,2444T@183968|Thermococci	183968|Thermococci	S	Ribonuclease III	-	-	-	-	-	-	-	-	-	-	-	-	Ribonucleas_3_2
PYH3_k127_1399485_35	679926.Mpet_1691	1.919e-47	177.0	COG1628@1|root,arCOG00928@2157|Archaea,2XXBV@28890|Euryarchaeota,2N9K3@224756|Methanomicrobia	224756|Methanomicrobia	L	Belongs to the UPF0215 family	-	-	-	ko:K09120	-	-	-	-	ko00000	-	-	-	DUF99
PYH3_k127_1399485_57	453591.Igni_0852	1.893e-26	111.0	COG1594@1|root,arCOG00579@2157|Archaea,2XQQ6@28889|Crenarchaeota	28889|Crenarchaeota	K	Belongs to the archaeal rpoM eukaryotic RPA12 RPB9 RPC11 RNA polymerase family	tfs	GO:0003674,GO:0005488,GO:0006355,GO:0008150,GO:0008270,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141	-	ko:K03057	ko01100,map01100	-	-	-	br01611,ko00000,ko03021	-	-	-	RNA_POL_M_15KD,TFIIS_C
PYH3_k127_1399485_36	633148.Tagg_0042	1.09e-46	177.0	COG0592@1|root,arCOG00488@2157|Archaea,2XQCF@28889|Crenarchaeota	28889|Crenarchaeota	L	Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication	pcn	GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006272,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0022616,GO:0030234,GO:0030337,GO:0032991,GO:0034641,GO:0034645,GO:0043170,GO:0043626,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0044796,GO:0046483,GO:0050790,GO:0065007,GO:0065009,GO:0071704,GO:0090304,GO:0098772,GO:1901360,GO:1901576	-	ko:K04802	ko03030,ko03410,ko03420,ko03430,ko04110,ko04530,ko05161,ko05166,map03030,map03410,map03420,map03430,map04110,map04530,map05161,map05166	M00295	-	-	ko00000,ko00001,ko00002,ko03032,ko03400	-	-	-	PCNA_C,PCNA_N
PYH3_k127_1399485_30	192952.MM_1396	1.366e-50	193.0	COG2219@1|root,arCOG03013@2157|Archaea,2XTDT@28890|Euryarchaeota,2N9HY@224756|Methanomicrobia	224756|Methanomicrobia	L	Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair	priL	-	-	ko:K18882	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_primase_lrg
PYH3_k127_1399485_23	368408.Tpen_0622	1.037e-67	246.0	COG1467@1|root,arCOG04110@2157|Archaea,2XQI5@28889|Crenarchaeota	28889|Crenarchaeota	L	Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair	priS	GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0003896,GO:0003899,GO:0005488,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006269,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901363,GO:1901576	-	ko:K02683	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_primase_S
PYH3_k127_1399485_77	1459636.NTE_00425	0.0001802	52.0	COG1711@1|root,arCOG00551@2157|Archaea,41SVQ@651137|Thaumarchaeota	651137|Thaumarchaeota	L	protein conserved in archaea	-	-	-	ko:K09723	-	-	-	-	ko00000,ko03032	-	-	-	-
PYH3_k127_1399485_54	1459636.NTE_03120	8.018e-28	115.0	COG1631@1|root,arCOG04109@2157|Archaea,41SQZ@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Binds to the 23S rRNA	rpl44e	-	-	ko:K02929	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L44
PYH3_k127_1399485_68	573063.Metin_0775	5.799e-15	78.0	COG2051@1|root,arCOG04108@2157|Archaea,2XZW2@28890|Euryarchaeota,23R97@183939|Methanococci	183939|Methanococci	J	PFAM Ribosomal protein S27E	rps27e	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02978	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S27e
PYH3_k127_1399485_29	272844.PAB0568	3.074e-55	202.0	COG1093@1|root,arCOG04107@2157|Archaea,2XTV0@28890|Euryarchaeota,243FV@183968|Thermococci	183968|Thermococci	J	eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA	eif2a	GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K03237	ko03013,ko04138,ko04140,ko04141,ko04210,ko04932,ko05160,ko05162,ko05164,ko05168,map03013,map04138,map04140,map04141,map04210,map04932,map05160,map05162,map05164,map05168	-	-	-	ko00000,ko00001,ko03012	-	-	-	EIF_2_alpha,S1
PYH3_k127_1399485_72	436308.Nmar_0076	4.284e-11	65.0	COG2260@1|root,arCOG00906@2157|Archaea,41SUI@651137|Thaumarchaeota	651137|Thaumarchaeota	J	more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA	nop10	-	-	ko:K11130	ko03008,map03008	M00425	-	-	ko00000,ko00001,ko00002,ko03009,ko03032	-	-	-	Nop10p
PYH3_k127_1399485_34	224325.AF_0525	2.774e-48	184.0	COG2047@1|root,arCOG00348@2157|Archaea,2XSX4@28890|Euryarchaeota,2463Z@183980|Archaeoglobi	183980|Archaeoglobi	S	PAC2 family	-	-	-	ko:K07159	-	-	-	-	ko00000	-	-	-	PAC2
PYH3_k127_1399485_20	3641.EOY19667	4.481e-77	289.0	COG1287@1|root,KOG2292@2759|Eukaryota,37M0F@33090|Viridiplantae,3G8TE@35493|Streptophyta	35493|Streptophyta	O	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit	STT3B	GO:0003674,GO:0003824,GO:0004576,GO:0004579,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005789,GO:0005886,GO:0006464,GO:0006486,GO:0006487,GO:0006807,GO:0008150,GO:0008152,GO:0008250,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009987,GO:0012505,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0018193,GO:0018196,GO:0018279,GO:0019538,GO:0031984,GO:0032991,GO:0034645,GO:0036211,GO:0042175,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0043413,GO:0043687,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0070085,GO:0071704,GO:0071944,GO:0098796,GO:0098827,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1902494,GO:1990234	2.4.99.18	ko:K07151	ko00510,ko00513,ko01100,ko04141,map00510,map00513,map01100,map04141	M00072	R04216,R05976	RC00005,RC00482	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT66	-	STT3
PYH3_k127_1399485_0	368408.Tpen_0130	9.052e-310	983.0	COG0060@1|root,arCOG00807@2157|Archaea,2XPWM@28889|Crenarchaeota	28889|Crenarchaeota	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
PYH3_k127_1399485_73	247490.KSU1_D0453	2.186e-09	63.0	2EGSE@1|root,33AII@2|Bacteria,2J3TB@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_1399485_44	330214.NIDE2201	5.219e-40	157.0	COG2755@1|root,COG2755@2|Bacteria	2|Bacteria	E	lipolytic protein G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
PYH3_k127_1399485_48	1160707.AJIK01000016_gene2745	7.174e-36	140.0	COG0509@1|root,COG0509@2|Bacteria,1V6WV@1239|Firmicutes,4HIMA@91061|Bacilli,26F58@186818|Planococcaceae	91061|Bacilli	E	Is also involved in protein lipoylation via its role as an octanoyl lipoyl carrier protein intermediate	gcvH	GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
PYH3_k127_1399485_49	426368.MmarC7_0973	2.165e-34	137.0	COG0575@1|root,arCOG04106@2157|Archaea,2XWNR@28890|Euryarchaeota,23QZ6@183939|Methanococci	183939|Methanococci	I	Catalyzes the formation of CDP-2,3-bis-(O- geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O- geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids	carS	-	2.7.7.67	ko:K19664	ko00564,map00564	-	R08966	RC00002	ko00000,ko00001,ko01000	-	-	-	CarS-like
PYH3_k127_1399485_71	69781.S7Z6F4	5.392e-14	81.0	COG0468@1|root,KOG1564@2759|Eukaryota,38E66@33154|Opisthokonta,3NY37@4751|Fungi,3QRB4@4890|Ascomycota,20CPK@147545|Eurotiomycetes,3S7GU@5042|Eurotiales	4751|Fungi	L	DNA repair protein	rhp57	GO:0000003,GO:0000150,GO:0000217,GO:0000280,GO:0000400,GO:0000707,GO:0000722,GO:0000723,GO:0000724,GO:0000725,GO:0000730,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003697,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005657,GO:0005694,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006312,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007049,GO:0007127,GO:0007131,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022402,GO:0022414,GO:0022607,GO:0030491,GO:0032200,GO:0032991,GO:0033061,GO:0033062,GO:0033063,GO:0033170,GO:0033554,GO:0034622,GO:0034641,GO:0035825,GO:0035861,GO:0042148,GO:0042592,GO:0042623,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044446,GO:0044464,GO:0045003,GO:0046483,GO:0046982,GO:0046983,GO:0048285,GO:0050896,GO:0051276,GO:0051321,GO:0051716,GO:0060249,GO:0061982,GO:0065003,GO:0065004,GO:0065007,GO:0065008,GO:0071704,GO:0071824,GO:0071840,GO:0090304,GO:0090734,GO:0090735,GO:0097159,GO:0140013,GO:0140097,GO:1901360,GO:1901363,GO:1903046	-	ko:K10880,ko:K10958	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	Rad51
PYH3_k127_1399485_45	368408.Tpen_0195	1.446e-38	158.0	COG5623@1|root,arCOG04127@2157|Archaea,2XPVW@28889|Crenarchaeota	28889|Crenarchaeota	A	PFAM Molybdopterin guanine dinucleotide synthesis protein B	-	-	-	ko:K06947	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	CLP1_P
PYH3_k127_1399485_12	386456.JQKN01000014_gene3125	4.858e-96	327.0	COG2423@1|root,arCOG01035@2157|Archaea,2XTTC@28890|Euryarchaeota,23PUF@183925|Methanobacteria	183925|Methanobacteria	E	Catalyzes the NAD( )-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate	ala	-	1.4.1.1	ko:K19244	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	OCD_Mu_crystall
PYH3_k127_1399485_8	118163.Ple7327_0425	1.319e-130	428.0	COG0436@1|root,COG0436@2|Bacteria,1GHX7@1117|Cyanobacteria,3VM7E@52604|Pleurocapsales	1117|Cyanobacteria	E	PFAM Aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
PYH3_k127_1399485_33	335543.Sfum_0345	1.415e-48	186.0	COG2306@1|root,COG2306@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF402)	-	-	-	ko:K07586,ko:K09145	-	-	-	-	ko00000	-	-	-	DUF402
PYH3_k127_1399485_7	1449126.JQKL01000004_gene620	5.667e-140	456.0	COG0154@1|root,COG0154@2|Bacteria,1TP0C@1239|Firmicutes,24911@186801|Clostridia,2689E@186813|unclassified Clostridiales	186801|Clostridia	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	-	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
PYH3_k127_1399485_1	290512.Paes_1085	1.483e-268	851.0	COG0433@1|root,COG0433@2|Bacteria,1FEIF@1090|Chlorobi	1090|Chlorobi	S	AAA-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF87
PYH3_k127_1399485_41	1365176.N186_07110	4.987e-44	169.0	COG0013@1|root,arCOG01254@2157|Archaea,2XQGA@28889|Crenarchaeota	28889|Crenarchaeota	J	Threonyl and Alanyl tRNA synthetase second additional domain	-	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2c,tRNA_SAD
PYH3_k127_1399485_9	368407.Memar_0876	4.184e-130	426.0	COG0535@1|root,arCOG00938@2157|Archaea,2XUJG@28890|Euryarchaeota,2N9IV@224756|Methanomicrobia	224756|Methanomicrobia	S	SMART Elongator protein 3 MiaB NifB	-	-	-	ko:K22226	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SPASM
PYH3_k127_1399485_51	1408422.JHYF01000012_gene3081	1.088e-33	135.0	COG1522@1|root,COG1522@2|Bacteria,1V6TH@1239|Firmicutes,24JH9@186801|Clostridia,36JUP@31979|Clostridiaceae	186801|Clostridia	K	transcriptional regulator, AsnC family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_AsnC-type
PYH3_k127_1399485_58	349161.Dred_2158	5.979e-26	122.0	COG1522@1|root,COG1522@2|Bacteria,1V6TK@1239|Firmicutes,24KE6@186801|Clostridia,2627S@186807|Peptococcaceae	186801|Clostridia	K	SMART Transcription regulator, AsnC-type	nirD	-	-	-	-	-	-	-	-	-	-	-	HTH_AsnC-type
PYH3_k127_1399485_52	386456.JQKN01000002_gene2388	2.11e-32	141.0	COG1587@1|root,arCOG02048@2157|Archaea,2XTA1@28890|Euryarchaeota,23NZX@183925|Methanobacteria	183925|Methanobacteria	H	synthase	hemD	-	4.2.1.75	ko:K01719	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165	RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4
PYH3_k127_1399485_17	643648.Slip_1426	5.139e-81	277.0	COG0007@1|root,COG1587@1|root,COG0007@2|Bacteria,COG1587@2|Bacteria,1TQNH@1239|Firmicutes,2487I@186801|Clostridia,42JPK@68298|Syntrophomonadaceae	186801|Clostridia	H	Belongs to the precorrin methyltransferase family	cobA	-	1.3.1.76,2.1.1.107,4.2.1.75,4.99.1.4	ko:K02302,ko:K02303,ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03165,R03194,R03947	RC00003,RC00871,RC01012,RC01034,RC01861	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS15755	HEM4,Porphobil_deam,Porphobil_deamC,TP_methylase
PYH3_k127_1399485_15	1459636.NTE_01012	1.734e-82	284.0	COG0181@1|root,arCOG04299@2157|Archaea,41S6Z@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	-	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	-	Porphobil_deam,Porphobil_deamC
PYH3_k127_1399485_5	565033.GACE_0110	3.979e-142	462.0	COG0001@1|root,arCOG00918@2157|Archaea,2XTRI@28890|Euryarchaeota,245Z9@183980|Archaeoglobi	183980|Archaeoglobi	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
PYH3_k127_1399485_10	429009.Adeg_1257	6.442e-126	411.0	COG0113@1|root,COG0113@2|Bacteria,1TP09@1239|Firmicutes,2496V@186801|Clostridia,42EWI@68295|Thermoanaerobacterales	186801|Clostridia	H	Delta-aminolevulinic acid dehydratase	hemB	-	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iHN637.CLJU_RS15750	ALAD
PYH3_k127_1399485_19	1220534.B655_0419	1.302e-77	275.0	COG0373@1|root,arCOG01036@2157|Archaea,2XTTG@28890|Euryarchaeota,23NUA@183925|Methanobacteria	183925|Methanobacteria	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	-	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
PYH3_k127_1399485_55	868131.MSWAN_0201	1.176e-27	120.0	COG1648@1|root,arCOG01044@2157|Archaea,2XWMY@28890|Euryarchaeota,23P2N@183925|Methanobacteria	183925|Methanobacteria	H	synthase	cysG	-	1.3.1.76,4.99.1.4	ko:K02304	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03947	RC01012,RC01034	ko00000,ko00001,ko00002,ko01000	-	-	-	NAD_binding_7
PYH3_k127_1399485_53	374847.Kcr_0770	5.462e-30	127.0	COG1522@1|root,arCOG01580@2157|Archaea	2157|Archaea	K	COG1522 Transcriptional regulators	-	-	-	ko:K03718	-	-	-	-	ko00000,ko03000	-	-	-	HTH_AsnC-type
PYH3_k127_1399485_76	591019.Shell_0193	0.0001596	53.0	arCOG04155@1|root,arCOG04155@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_1399485_27	529709.PYCH_03610	2.395e-58	210.0	COG0639@1|root,arCOG01143@2157|Archaea,2XUDG@28890|Euryarchaeota,2435N@183968|Thermococci	183968|Thermococci	T	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos_2
PYH3_k127_1399485_18	1459636.NTE_01027	3.332e-79	280.0	COG1078@1|root,arCOG04430@2157|Archaea,41T0P@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K06885	-	-	-	-	ko00000	-	-	-	HD
PYH3_k127_1399485_42	70601.3258125	3.452e-41	160.0	COG0125@1|root,arCOG01891@2157|Archaea,2XTAM@28890|Euryarchaeota,242TV@183968|Thermococci	183968|Thermococci	F	thymidylate kinase	tmk	GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
PYH3_k127_1399485_2	1209989.TepiRe1_0613	1.664e-197	638.0	COG1152@1|root,COG1614@1|root,COG1152@2|Bacteria,COG1614@2|Bacteria,1TSWZ@1239|Firmicutes,248Y2@186801|Clostridia,42EW2@68295|Thermoanaerobacterales	186801|Clostridia	C	CO dehydrogenase acetyl-CoA synthase complex beta subunit	cdhC	-	2.3.1.169	ko:K14138	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00377	R08433,R10243	RC00004,RC00113,RC01144,RC02963,RC02964,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhC
PYH3_k127_1399485_6	234267.Acid_1940	1.69e-140	454.0	COG3386@1|root,COG3386@2|Bacteria,3Y6YH@57723|Acidobacteria	57723|Acidobacteria	G	SMP-30/Gluconolaconase/LRE-like region	-	-	-	-	-	-	-	-	-	-	-	-	SGL
PYH3_k127_1399485_26	589924.Ferp_0844	2.31e-58	226.0	COG1138@1|root,arCOG06807@1|root,arCOG00270@2157|Archaea,arCOG06807@2157|Archaea,2XUDS@28890|Euryarchaeota,245X5@183980|Archaeoglobi	183980|Archaeoglobi	O	c-type cytochrome biogenesis protein CcmF	-	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
PYH3_k127_1399485_69	471854.Dfer_0576	6.342e-15	85.0	COG0454@1|root,COG0456@2|Bacteria,4NT7Q@976|Bacteroidetes,47VTT@768503|Cytophagia	976|Bacteroidetes	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
PYH3_k127_1399485_24	1459636.NTE_01556	5.802e-67	233.0	arCOG00517@1|root,arCOG00517@2157|Archaea,41SHJ@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
PYH3_k127_1399485_50	237368.SCABRO_00982	1.008e-33	140.0	COG2014@1|root,COG2014@2|Bacteria	2|Bacteria	F	Putative heavy-metal chelation	-	-	-	ko:K09138	-	-	-	-	ko00000	-	-	-	DUF364,DUF4213
PYH3_k127_1399485_62	1365176.N186_04575	8.435e-18	87.0	COG1645@1|root,arCOG00578@2157|Archaea,2XR3I@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM Sjogrens syndrome scleroderma autoantigen 1	-	-	-	ko:K07143	-	-	-	-	ko00000	-	-	-	Auto_anti-p27
PYH3_k127_1399485_60	933801.Ahos_0533	2.285e-23	102.0	COG1698@1|root,arCOG04308@2157|Archaea,2XQVN@28889|Crenarchaeota	28889|Crenarchaeota	S	Belongs to the UPF0147 family	-	-	-	ko:K09721	-	-	-	-	ko00000	-	-	-	UPF0147
PYH3_k127_1482636_2	868131.MSWAN_1995	1.783e-27	117.0	COG3467@1|root,arCOG00520@2157|Archaea,2XXWD@28890|Euryarchaeota	28890|Euryarchaeota	S	PFAM pyridoxamine 5'-phosphate oxidase-related, FMN-binding	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Pyridox_ox_2
PYH3_k127_1482636_0	926692.AZYG01000086_gene736	8.452e-48	181.0	COG1030@1|root,COG1030@2|Bacteria,1V6UR@1239|Firmicutes,24D2S@186801|Clostridia,3WBYU@53433|Halanaerobiales	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	TspO_MBR
PYH3_k127_1482636_3	580340.Tlie_1588	1.086e-07	55.0	28XQZ@1|root,2ZJMK@2|Bacteria,3TCGY@508458|Synergistetes	508458|Synergistetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_1482636_1	453591.Igni_1337	1.143e-37	144.0	COG1173@1|root,arCOG00749@2157|Archaea,2XPU7@28889|Crenarchaeota	28889|Crenarchaeota	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
PYH3_k127_1506442_0	1304284.L21TH_1732	3.216e-82	280.0	COG1236@1|root,COG1236@2|Bacteria,1TQBH@1239|Firmicutes,248QR@186801|Clostridia,36DQZ@31979|Clostridiaceae	186801|Clostridia	J	metallo-beta-lactamase	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,Lactamase_B_6,RMMBL
PYH3_k127_1506442_2	177437.HRM2_10530	1.784e-28	119.0	COG1047@1|root,COG1047@2|Bacteria,1RD35@1224|Proteobacteria,42MCS@68525|delta/epsilon subdivisions,2WQGI@28221|Deltaproteobacteria,2MK26@213118|Desulfobacterales	28221|Deltaproteobacteria	O	peptidyl-prolyl cis-trans isomerase	-	-	5.2.1.8	ko:K01802	-	-	-	-	ko00000,ko01000	-	-	-	FKBP_C
PYH3_k127_1506442_1	926692.AZYG01000040_gene1505	8.463e-56	222.0	COG0507@1|root,COG1112@1|root,COG0507@2|Bacteria,COG1112@2|Bacteria,1TR8E@1239|Firmicutes,24B4D@186801|Clostridia,3WACJ@53433|Halanaerobiales	186801|Clostridia	L	TIGRFAM DNA helicase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_11,AAA_12,DbpA
PYH3_k127_1506442_3	204536.SULAZ_0008	6.737e-20	103.0	COG0420@1|root,COG0420@2|Bacteria,2G45D@200783|Aquificae	200783|Aquificae	L	SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity	sbcD	-	-	ko:K03547	-	-	-	-	ko00000,ko03400	-	-	-	Metallophos
PYH3_k127_1506442_4	634498.mru_1106	8.56e-11	69.0	COG0419@1|root,arCOG00368@2157|Archaea,2XTC7@28890|Euryarchaeota,23PEH@183925|Methanobacteria	183925|Methanobacteria	L	Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50 Mre11 complex	rad50	-	-	ko:K03546	-	-	-	-	ko00000,ko03400	-	-	-	AAA_21,AAA_23,Rad50_zn_hook,SMC_N
PYH3_k127_1513390_13	1365176.N186_03390	2.063e-41	158.0	COG0091@1|root,arCOG04098@2157|Archaea,2XQCP@28889|Crenarchaeota	28889|Crenarchaeota	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rpl22	-	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
PYH3_k127_1513390_20	399549.Msed_2053	5.234e-11	69.0	arCOG05900@1|root,arCOG05900@2157|Archaea,2XRDZ@28889|Crenarchaeota	28889|Crenarchaeota	K	regulatory protein, arsR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,LexA_DNA_bind
PYH3_k127_1513390_12	529709.PYCH_01410	9.69e-44	163.0	COG0185@1|root,arCOG04099@2157|Archaea,2XWI9@28890|Euryarchaeota,24405@183968|Thermococci	183968|Thermococci	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rps19p	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
PYH3_k127_1513390_8	591019.Shell_1444	5.272e-73	253.0	COG0090@1|root,arCOG04067@2157|Archaea,2XPW8@28889|Crenarchaeota	28889|Crenarchaeota	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rpl2	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
PYH3_k127_1513390_17	342949.PNA2_0380	1.65e-23	102.0	COG0089@1|root,arCOG04072@2157|Archaea,2XYPG@28890|Euryarchaeota,244AA@183968|Thermococci	183968|Thermococci	J	Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome	rpl23	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
PYH3_k127_1513390_7	1220534.B655_1959	1.587e-74	258.0	COG0469@1|root,arCOG04071@2157|Archaea,2XTXX@28890|Euryarchaeota,23NJ7@183925|Methanobacteria	183925|Methanobacteria	J	50S ribosomal protein L4	rpl4	-	-	ko:K02930	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
PYH3_k127_1513390_4	523845.AQXV01000031_gene1139	2.591e-90	308.0	COG0087@1|root,arCOG04070@2157|Archaea,2XT9B@28890|Euryarchaeota,23QD1@183939|Methanococci	183939|Methanococci	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rpl3	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
PYH3_k127_1513390_10	634498.mru_0850	8.427e-53	197.0	COG2106@1|root,arCOG04069@2157|Archaea,2XSZI@28890|Euryarchaeota,23NTH@183925|Methanobacteria	183925|Methanobacteria	S	Putative RNA methyltransferase	-	-	-	ko:K09142	-	-	-	-	ko00000	-	-	-	Methyltrn_RNA_3
PYH3_k127_1513390_11	1379698.RBG1_1C00001G1620	2.083e-49	191.0	COG2222@1|root,COG2222@2|Bacteria,2NQVV@2323|unclassified Bacteria	2|Bacteria	M	Bacterial phospho-glucose isomerase C-terminal SIS domain	pgi	-	5.3.1.8,5.3.1.9	ko:K15916	ko00010,ko00030,ko00051,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R01819,R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	SIS,bact-PGI_C
PYH3_k127_1513390_1	391623.TERMP_00599	8.868e-197	624.0	COG1690@1|root,arCOG04246@2157|Archaea,2XTIC@28890|Euryarchaeota,24310@183968|Thermococci	183968|Thermococci	J	tRNA-splicing ligase that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs	rtcB	GO:0000166,GO:0000394,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003972,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008380,GO:0008452,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016886,GO:0017076,GO:0019001,GO:0019002,GO:0030145,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901363	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Intein_splicing,LAGLIDADG_3,RtcB
PYH3_k127_1513390_15	273063.STK_04060	2.014e-33	134.0	COG1371@1|root,arCOG04055@2157|Archaea,2XQYK@28889|Crenarchaeota	28889|Crenarchaeota	J	Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently	-	-	-	-	-	-	-	-	-	-	-	-	Archease
PYH3_k127_1513390_21	5762.XP_002674029.1	5.586e-11	67.0	COG5133@1|root,KOG3381@2759|Eukaryota	2759|Eukaryota	B	chromosome segregation	-	GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016043,GO:0016226,GO:0019538,GO:0022607,GO:0031163,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0051186,GO:0051604,GO:0071704,GO:0071840,GO:0097428,GO:0106035,GO:1901564	-	-	-	-	-	-	-	-	-	-	FeS_assembly_P
PYH3_k127_1513390_16	1054217.TALC_01282	2.761e-28	121.0	COG1945@1|root,arCOG04490@2157|Archaea	2157|Archaea	S	Pyruvoyl-dependent arginine decarboxylase	pdaD	-	4.1.1.19	ko:K02626	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A2039	PvlArgDC
PYH3_k127_1513390_18	1131266.ARWQ01000005_gene818	4.032e-18	87.0	COG1599@1|root,arCOG01510@2157|Archaea,41SV1@651137|Thaumarchaeota	651137|Thaumarchaeota	L	COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins	-	-	-	ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko03000,ko03032,ko03400	-	-	-	tRNA_anti-codon
PYH3_k127_1513390_0	368408.Tpen_0325	3.65e-286	902.0	COG0525@1|root,arCOG00808@2157|Archaea,2XPW9@28889|Crenarchaeota	28889|Crenarchaeota	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
PYH3_k127_1513390_9	439481.Aboo_0810	4.445e-64	230.0	COG1235@1|root,arCOG00499@2157|Archaea,2XT48@28890|Euryarchaeota,3F2JB@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
PYH3_k127_1513390_19	1131266.ARWQ01000006_gene246	4.797e-11	74.0	arCOG08741@1|root,arCOG08741@2157|Archaea,41SWQ@651137|Thaumarchaeota	651137|Thaumarchaeota	E	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
PYH3_k127_1513390_2	515635.Dtur_0921	9.628e-150	483.0	COG1812@1|root,COG1812@2|Bacteria	2|Bacteria	E	S-adenosylmethionine synthetase (AdoMet synthetase)	metK-2	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	AdoMet_Synthase
PYH3_k127_1513390_14	1499967.BAYZ01000076_gene805	2.834e-40	155.0	2DS8H@1|root,32USH@2|Bacteria	2|Bacteria	S	Putative redox-active protein (C_GCAxxG_C_C)	-	-	-	-	-	-	-	-	-	-	-	-	C_GCAxxG_C_C
PYH3_k127_1513390_5	1379698.RBG1_1C00001G0892	4.779e-88	301.0	COG1062@1|root,COG1062@2|Bacteria	2|Bacteria	C	S-(hydroxymethyl)glutathione dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N
PYH3_k127_1513390_6	706587.Desti_2480	1.563e-80	276.0	COG4912@1|root,COG4912@2|Bacteria,1RGVM@1224|Proteobacteria,42ZZV@68525|delta/epsilon subdivisions,2WVCM@28221|Deltaproteobacteria,2MRS8@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	DNA alkylation repair enzyme	-	-	-	-	-	-	-	-	-	-	-	-	DNA_alkylation
PYH3_k127_1513390_3	304371.MCP_2481	1.821e-131	428.0	COG1759@1|root,arCOG04346@2157|Archaea,2XUFR@28890|Euryarchaeota,2N9HE@224756|Methanomicrobia	224756|Methanomicrobia	F	Protein of unknown function (DUF1246)	-	-	6.3.4.23	ko:K06863	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R06975	RC00263,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1246,DUF1297
PYH3_k127_1532565_3	694429.Pyrfu_0369	0.000683	47.0	arCOG00552@1|root,arCOG00552@2157|Archaea,2XR6J@28889|Crenarchaeota	28889|Crenarchaeota	L	GINS complex protein	-	-	-	ko:K09723	-	-	-	-	ko00000,ko03032	-	-	-	Sld5
PYH3_k127_1532565_2	589924.Ferp_1683	2.532e-59	222.0	COG0683@1|root,arCOG01020@2157|Archaea,2XVWV@28890|Euryarchaeota,245XV@183980|Archaeoglobi	183980|Archaeoglobi	E	Periplasmic binding protein domain	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
PYH3_k127_1532565_0	1009370.ALO_19767	5.099e-96	321.0	COG0543@1|root,COG0543@2|Bacteria,1TP6D@1239|Firmicutes,4H2FP@909932|Negativicutes	909932|Negativicutes	C	PFAM oxidoreductase FAD NAD(P)-binding domain protein	pyrK_1	-	1.18.1.2,1.19.1.1	ko:K00528	-	-	R10159	-	ko00000,ko01000	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
PYH3_k127_1532565_1	1449126.JQKL01000010_gene463	2.63e-82	280.0	COG0493@1|root,COG0493@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,267YC@186813|unclassified Clostridiales	186801|Clostridia	C	Psort location Cytoplasmic, score	gltA	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
PYH3_k127_1629308_1	880073.Calab_2318	5.115e-05	53.0	COG0500@1|root,COG2226@2|Bacteria,2NR2G@2323|unclassified Bacteria	2|Bacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25
PYH3_k127_1629308_0	589924.Ferp_1683	4.801e-24	110.0	COG0683@1|root,arCOG01020@2157|Archaea,2XVWV@28890|Euryarchaeota,245XV@183980|Archaeoglobi	183980|Archaeoglobi	E	Periplasmic binding protein domain	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
PYH3_k127_1663132_7	926569.ANT_26550	2.674e-17	89.0	COG3212@1|root,COG3212@2|Bacteria	2|Bacteria	T	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	PepSY
PYH3_k127_1663132_8	869210.Marky_2134	1.22e-07	59.0	COG3462@1|root,COG3462@2|Bacteria	2|Bacteria	S	membrane protein (DUF2078)	-	-	-	ko:K08982	-	-	-	-	ko00000	-	-	-	SHOCT
PYH3_k127_1663132_1	660470.Theba_0060	3.411e-89	313.0	COG2159@1|root,COG2159@2|Bacteria	2|Bacteria	E	amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
PYH3_k127_1663132_0	264732.Moth_1287	7.365e-152	489.0	COG0426@1|root,COG0426@2|Bacteria,1TQE9@1239|Firmicutes,249CU@186801|Clostridia,42FP2@68295|Thermoanaerobacterales	186801|Clostridia	C	flavodoxin nitric oxide synthase	norV	-	1.6.3.4	ko:K22405	-	-	-	-	ko00000,ko01000	-	-	-	Flavodoxin_1,Lactamase_B
PYH3_k127_1663132_2	269797.Mbar_A0560	3.353e-88	303.0	COG0389@1|root,arCOG04582@2157|Archaea,2XTZZ@28890|Euryarchaeota,2NA7S@224756|Methanomicrobia	224756|Methanomicrobia	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis	-	-	2.7.7.7	ko:K04479	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
PYH3_k127_1663132_5	436308.Nmar_0715	9.605e-24	105.0	COG1310@1|root,arCOG01139@2157|Archaea,41SQ7@651137|Thaumarchaeota	651137|Thaumarchaeota	S	metal-dependent protease of the PAD1 JAB1 superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Prok-JAB
PYH3_k127_1663132_3	693661.Arcve_1580	2.844e-78	282.0	COG0038@1|root,arCOG02569@2157|Archaea,2XW6N@28890|Euryarchaeota,2461Y@183980|Archaeoglobi	183980|Archaeoglobi	P	Chloride channel	-	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	-	CBS,Voltage_CLC
PYH3_k127_1663132_4	1210908.HSB1_04910	5.254e-43	167.0	COG2041@1|root,arCOG00264@2157|Archaea,2XU2G@28890|Euryarchaeota,23SCW@183963|Halobacteria	183963|Halobacteria	S	COG2041 Sulfite oxidase and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_molyb
PYH3_k127_1663132_6	1382304.JNIL01000001_gene2826	3.074e-21	100.0	COG0500@1|root,COG2226@2|Bacteria,1VAEA@1239|Firmicutes,4HIUG@91061|Bacilli	91061|Bacilli	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
PYH3_k127_1665462_3	1121405.dsmv_1537	7.726e-151	483.0	COG0369@1|root,COG1151@2|Bacteria,1N88B@1224|Proteobacteria,42M2C@68525|delta/epsilon subdivisions,2WIVE@28221|Deltaproteobacteria,2MJD6@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O	hcp	-	1.7.99.1	ko:K05601	ko00910,map00910	-	R00143	RC02797	ko00000,ko00001,ko01000	-	-	-	Prismane
PYH3_k127_1665462_22	272844.PAB1229	0.0007856	46.0	COG0640@1|root,arCOG01683@2157|Archaea,2Y3PS@28890|Euryarchaeota,243P1@183968|Thermococci	183968|Thermococci	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
PYH3_k127_1665462_8	387631.Asulf_01857	4.399e-59	222.0	COG0683@1|root,arCOG01020@2157|Archaea,2XVWV@28890|Euryarchaeota,245XV@183980|Archaeoglobi	183980|Archaeoglobi	E	Periplasmic binding protein domain	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
PYH3_k127_1665462_5	1343739.PAP_04815	5.106e-102	342.0	COG1184@1|root,arCOG01124@2157|Archaea,2XUFM@28890|Euryarchaeota,2434J@183968|Thermococci	183968|Thermococci	J	Belongs to the eIF-2B alpha beta delta subunits family	-	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0019509,GO:0019752,GO:0043094,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046523,GO:0071265,GO:0071267,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.29	ko:K18237	-	-	-	-	ko00000,ko01000	-	-	-	IF-2B
PYH3_k127_1665462_2	368408.Tpen_0093	1.771e-155	506.0	COG0213@1|root,arCOG02013@2157|Archaea,2XPZT@28889|Crenarchaeota	28889|Crenarchaeota	F	Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO	-	-	2.4.2.57	ko:K18931	-	-	R10836,R10837,R10838	RC00063	ko00000,ko01000	-	-	-	CDC48_N,Glycos_trans_3N,Glycos_transf_3,PYNP_C
PYH3_k127_1665462_4	693661.Arcve_0786	7.929e-145	470.0	COG1850@1|root,arCOG04443@2157|Archaea,2XVBP@28890|Euryarchaeota,245T4@183980|Archaeoglobi	183980|Archaeoglobi	G	Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase	rbcL	-	4.1.1.39	ko:K01601	ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200	M00165,M00166,M00532	R00024,R03140	RC00172,RC00859	ko00000,ko00001,ko00002,ko01000	-	-	-	RuBisCO_large,RuBisCO_large_N
PYH3_k127_1665462_9	192952.MM_0073	1.681e-53	196.0	COG0120@1|root,arCOG01122@2157|Archaea,2XTXI@28890|Euryarchaeota,2N9IQ@224756|Methanomicrobia	224756|Methanomicrobia	G	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate	rpiA	-	5.3.1.6	ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167,M00580	R01056	RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	Rib_5-P_isom_A
PYH3_k127_1665462_6	515635.Dtur_0864	4.375e-79	279.0	COG0644@1|root,COG0644@2|Bacteria	2|Bacteria	C	geranylgeranyl reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3,FAD_oxidored,Trp_halogenase
PYH3_k127_1665462_16	1267534.KB906756_gene645	4.806e-20	102.0	COG1470@1|root,COG3391@1|root,COG4934@1|root,COG1470@2|Bacteria,COG3391@2|Bacteria,COG4934@2|Bacteria,3Y62V@57723|Acidobacteria,2JKVU@204432|Acidobacteriia	204432|Acidobacteriia	O	PFAM Peptidase S53, propeptide	-	-	-	-	-	-	-	-	-	-	-	-	Pro-kuma_activ
PYH3_k127_1665462_17	162425.CADANIAP00001467	1.611e-10	69.0	COG5078@1|root,KOG0423@2759|Eukaryota,38F8H@33154|Opisthokonta,3P325@4751|Fungi,3QUXJ@4890|Ascomycota,20C80@147545|Eurotiomycetes,3S4XP@5042|Eurotiales	4751|Fungi	O	Belongs to the ubiquitin-conjugating enzyme family	-	-	2.3.2.23	ko:K10583	ko04120,map04120	-	-	-	ko00000,ko00001,ko01000,ko04121	-	-	-	UQ_con
PYH3_k127_1665462_13	530564.Psta_4146	5.455e-31	137.0	COG0476@1|root,COG0476@2|Bacteria,2IY9K@203682|Planctomycetes	203682|Planctomycetes	H	PFAM UBA THIF-type NAD FAD binding protein	-	-	-	-	-	-	-	-	-	-	-	-	ThiF
PYH3_k127_1665462_21	877455.Metbo_1600	4.169e-06	60.0	arCOG02487@1|root,arCOG02555@1|root,arCOG03270@1|root,arCOG02487@2157|Archaea,arCOG02555@2157|Archaea,arCOG03270@2157|Archaea,2Y7UE@28890|Euryarchaeota,23PA5@183925|Methanobacteria	183925|Methanobacteria	S	Right handed beta helix region	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_5
PYH3_k127_1665462_7	1232453.BAIF02000027_gene4189	2.993e-61	227.0	COG0407@1|root,COG0407@2|Bacteria,1V4WM@1239|Firmicutes,24BVD@186801|Clostridia	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
PYH3_k127_1665462_10	697303.Thewi_2114	4.055e-53	194.0	COG5012@1|root,COG5012@2|Bacteria,1V1P0@1239|Firmicutes,24G08@186801|Clostridia,42FJI@68295|Thermoanaerobacterales	186801|Clostridia	S	Methionine synthase B12-binding module cap domain protein	-	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2
PYH3_k127_1665462_15	374847.Kcr_0936	3.82e-26	127.0	arCOG08038@1|root,arCOG08038@2157|Archaea	2157|Archaea	S	protein secretion by the type IV secretion system	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_1665462_20	234267.Acid_7022	3.138e-07	64.0	COG5555@1|root,COG5555@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
PYH3_k127_1665462_1	591019.Shell_1559	6.543e-195	622.0	COG0459@1|root,arCOG01257@2157|Archaea,2XPYR@28889|Crenarchaeota	28889|Crenarchaeota	O	PFAM chaperonin Cpn60 TCP-1	thsB	GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0042802,GO:0044183,GO:0051082,GO:0061077	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
PYH3_k127_1665462_18	70601.3257171	9.761e-10	65.0	COG1356@1|root,arCOG04554@2157|Archaea,2XXGH@28890|Euryarchaeota,243ZZ@183968|Thermococci	183968|Thermococci	K	Transcriptional regulator	tfx	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141	-	ko:K09714	-	-	-	-	ko00000	-	-	-	Sigma70_r4,TFX_C
PYH3_k127_1665462_11	667014.Thein_2107	1.898e-49	181.0	COG0437@1|root,COG0437@2|Bacteria,2GIJ6@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
PYH3_k127_1665462_0	368408.Tpen_1817	2.853e-226	715.0	COG2414@1|root,arCOG00706@2157|Archaea,2XPT1@28889|Crenarchaeota	28889|Crenarchaeota	C	Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
PYH3_k127_1665462_12	521011.Mpal_1987	3.399e-36	147.0	COG1994@1|root,arCOG00614@2157|Archaea,2XX7B@28890|Euryarchaeota	28890|Euryarchaeota	S	Peptidase M50	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_1665462_19	1197130.BAFM01000024_gene2976	2.572e-07	61.0	COG0705@1|root,arCOG01768@2157|Archaea,2XTJH@28890|Euryarchaeota,23SS3@183963|Halobacteria	183963|Halobacteria	E	nucleic acid binding protein containing the AN1-type Zn-finger	-	-	-	ko:K07059	-	-	-	-	ko00000	-	-	-	Rhomboid,zf-AN1
PYH3_k127_1665462_14	1236689.MMALV_02890	2.479e-27	113.0	COG0162@1|root,arCOG01886@2157|Archaea,2XTA0@28890|Euryarchaeota,3F2HA@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0004832,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	tRNA-synt_1b
PYH3_k127_1895513_1	1230343.CANP01000029_gene2243	3.768e-41	163.0	COG4948@1|root,COG4948@2|Bacteria,1MW76@1224|Proteobacteria,1RXJG@1236|Gammaproteobacteria,1JFMJ@118969|Legionellales	118969|Legionellales	M	Mandelate racemase / muconate lactonizing enzyme, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
PYH3_k127_1895513_2	1459636.NTE_00644	4.403e-27	116.0	arCOG07179@1|root,arCOG07179@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_1895513_0	349124.Hhal_0116	7.308e-91	308.0	COG0320@1|root,COG0320@2|Bacteria,1MVRD@1224|Proteobacteria,1RMAT@1236|Gammaproteobacteria,1WXEN@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	-	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
PYH3_k127_204342_3	485913.Krac_8495	1.923e-46	176.0	COG1143@1|root,COG2006@1|root,COG1143@2|Bacteria,COG2006@2|Bacteria	2|Bacteria	U	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF362,Fer4_17,FrhB_FdhB_C
PYH3_k127_204342_7	224325.AF_0601	4.789e-27	123.0	COG0500@1|root,arCOG01400@2157|Archaea,2Y0KF@28890|Euryarchaeota	28890|Euryarchaeota	Q	Methyltransferase FkbM domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_21
PYH3_k127_204342_8	1403819.BATR01000181_gene6162	1.919e-24	116.0	COG0438@1|root,COG0438@2|Bacteria,46WHJ@74201|Verrucomicrobia,2IVEA@203494|Verrucomicrobiae	203494|Verrucomicrobiae	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
PYH3_k127_204342_1	645991.Sgly_0859	1.026e-100	341.0	COG0535@1|root,COG0535@2|Bacteria,1UXWS@1239|Firmicutes,247NG@186801|Clostridia	186801|Clostridia	C	Radical SAM	-	-	-	ko:K22227	-	-	-	-	ko00000	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
PYH3_k127_204342_6	485913.Krac_8437	1.866e-33	140.0	COG1215@1|root,COG1215@2|Bacteria,2G8CP@200795|Chloroflexi	200795|Chloroflexi	M	Glycosyl transferase family group 2	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_204342_12	933801.Ahos_0101	1.669e-05	57.0	COG4346@1|root,arCOG00561@2157|Archaea,2XQ35@28889|Crenarchaeota	28889|Crenarchaeota	M	PFAM glycosyl transferase family 39	-	-	-	-	-	-	-	-	-	-	-	-	PMT,PMT_2
PYH3_k127_204342_9	453591.Igni_1169	1.784e-23	115.0	arCOG06883@1|root,arCOG06883@2157|Archaea,2XRBA@28889|Crenarchaeota	28889|Crenarchaeota	K	Winged helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_204342_11	768679.TTX_0072	4.306e-09	68.0	COG4346@1|root,arCOG00561@2157|Archaea,2XQ35@28889|Crenarchaeota	28889|Crenarchaeota	M	PFAM glycosyl transferase family 39	-	-	-	-	-	-	-	-	-	-	-	-	PMT,PMT_2
PYH3_k127_204342_2	1144275.COCOR_02785	1.262e-46	186.0	COG0433@1|root,COG0433@2|Bacteria,1MUSH@1224|Proteobacteria,42RE9@68525|delta/epsilon subdivisions,2WNSX@28221|Deltaproteobacteria,2YU8K@29|Myxococcales	28221|Deltaproteobacteria	S	AAA-like domain	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF853,DUF87
PYH3_k127_204342_4	693661.Arcve_1241	7.423e-37	150.0	COG2064@1|root,arCOG01808@2157|Archaea,2XT4Q@28890|Euryarchaeota,245QB@183980|Archaeoglobi	183980|Archaeoglobi	N	PFAM type II secretion system	-	-	-	ko:K07333	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSF
PYH3_k127_204342_5	1229909.NSED_05290	6.39e-35	146.0	COG2064@1|root,arCOG01808@2157|Archaea	2157|Archaea	NU	Type II secretion system	-	-	-	ko:K07333	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSF
PYH3_k127_204342_0	1229909.NSED_05285	3.043e-145	479.0	COG4962@1|root,arCOG01817@2157|Archaea,41T25@651137|Thaumarchaeota	651137|Thaumarchaeota	N	COG0630 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis	-	-	-	ko:K07332	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
PYH3_k127_204342_10	368408.Tpen_1214	1.735e-15	82.0	arCOG03871@1|root,arCOG03871@2157|Archaea,2XRGZ@28889|Crenarchaeota	28889|Crenarchaeota	N	TIGRFAM archaeal flagellin N-terminal-like domain	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_2180805_5	694429.Pyrfu_1064	1.582e-47	185.0	COG0683@1|root,arCOG01020@2157|Archaea,2XQM1@28889|Crenarchaeota	28889|Crenarchaeota	E	Periplasmic binding protein	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
PYH3_k127_2180805_13	56780.SYN_01364	0.0008616	51.0	COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42NFR@68525|delta/epsilon subdivisions	1224|Proteobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	GAF_2,HAMP,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
PYH3_k127_2180805_0	521011.Mpal_1433	0.0	1296.0	COG0574@1|root,arCOG01111@2157|Archaea,2XU2T@28890|Euryarchaeota,2N97B@224756|Methanomicrobia	224756|Methanomicrobia	G	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
PYH3_k127_2180805_8	1499967.BAYZ01000033_gene1105	1.409e-35	141.0	COG0655@1|root,COG0655@2|Bacteria	2|Bacteria	S	NAD(P)H dehydrogenase (quinone) activity	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
PYH3_k127_2180805_11	693661.Arcve_1058	5.507e-11	66.0	COG1280@1|root,arCOG01947@2157|Archaea,2XXV9@28890|Euryarchaeota,246CA@183980|Archaeoglobi	183980|Archaeoglobi	E	PFAM Lysine exporter protein (LYSE YGGA)	-	-	-	-	-	-	-	-	-	-	-	-	LysE
PYH3_k127_2180805_6	589865.DaAHT2_1598	1.191e-42	163.0	2C5Z2@1|root,32U5Z@2|Bacteria,1N4MT@1224|Proteobacteria,42TX0@68525|delta/epsilon subdivisions,2WQZM@28221|Deltaproteobacteria,2MKYF@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF3786)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3786
PYH3_k127_2180805_12	521460.Athe_0413	3.044e-06	58.0	2DBCH@1|root,2Z8DH@2|Bacteria,1UZYN@1239|Firmicutes,24B0Q@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	AMPK1_CBM
PYH3_k127_2180805_7	1343739.PAP_00210	4.723e-41	159.0	arCOG01792@1|root,arCOG01792@2157|Archaea,2XWRG@28890|Euryarchaeota,244Y6@183968|Thermococci	183968|Thermococci	Q	O-methyltransferase	-	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_25
PYH3_k127_2180805_10	1034943.BN1094_02354	2.318e-15	80.0	COG0662@1|root,COG0662@2|Bacteria,1RHWU@1224|Proteobacteria,1S5VV@1236|Gammaproteobacteria,1JF0R@118969|Legionellales	118969|Legionellales	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
PYH3_k127_2180805_9	1038859.AXAU01000011_gene2414	1.803e-27	115.0	COG3070@1|root,COG3070@2|Bacteria,1P6Z6@1224|Proteobacteria	1224|Proteobacteria	K	TfoX N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	TfoX_N
PYH3_k127_2180805_1	247490.KSU1_C0538	2.41e-145	466.0	COG1741@1|root,COG1741@2|Bacteria,2IXVU@203682|Planctomycetes	203682|Planctomycetes	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
PYH3_k127_2180805_2	1459636.NTE_01319	1.239e-100	333.0	arCOG00517@1|root,arCOG00517@2157|Archaea	2157|Archaea	P	COG0607 Rhodanese-related sulfurtransferase	-	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Lactamase_B,Rhodanese
PYH3_k127_2180805_3	1298920.KI911353_gene4460	6.42e-63	224.0	COG0500@1|root,COG2226@2|Bacteria,1UVHG@1239|Firmicutes,25KIB@186801|Clostridia,221KJ@1506553|Lachnoclostridium	186801|Clostridia	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
PYH3_k127_2180805_4	1089553.Tph_c23940	3.593e-59	214.0	COG0167@1|root,COG1149@1|root,COG0167@2|Bacteria,COG1149@2|Bacteria,1TRPI@1239|Firmicutes,24A0Z@186801|Clostridia,42FY6@68295|Thermoanaerobacterales	186801|Clostridia	C	TIGRFAM dihydroorotate dehydrogenase family protein	-	-	1.3.1.1,1.3.98.1	ko:K00226,ko:K17723	ko00240,ko00410,ko00770,ko01100,map00240,map00410,map00770,map01100	M00046,M00051	R00977,R01414,R01867,R11026	RC00051,RC00072,RC00123	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh,Fer4,Fer4_21
PYH3_k127_2269065_31	192952.MM_0081	0.0002416	44.0	COG2848@1|root,arCOG04321@2157|Archaea,2XU9Z@28890|Euryarchaeota,2N9BH@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterised ACR (DUF711)	-	-	-	ko:K09157	-	-	-	-	ko00000	-	-	-	DUF711
PYH3_k127_2269065_7	453591.Igni_1108	2.474e-104	354.0	COG0644@1|root,arCOG00570@2157|Archaea,2XPWV@28889|Crenarchaeota	28889|Crenarchaeota	C	TIGRFAM geranylgeranyl reductase	-	-	1.3.1.101,1.3.7.11	ko:K17830	ko00564,map00564	-	R10325,R10326,R10331	RC03134	ko00000,ko00001,ko01000	-	-	-	DAO,FAD_binding_2,FAD_binding_3,FAD_oxidored,Trp_halogenase
PYH3_k127_2269065_2	1121090.KB894716_gene2762	7.108e-152	491.0	COG0538@1|root,COG0538@2|Bacteria,1UHPE@1239|Firmicutes,4H9US@91061|Bacilli,1ZBWV@1386|Bacillus	91061|Bacilli	C	isocitrate	icd	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
PYH3_k127_2269065_11	1229909.NSED_02900	4.399e-54	192.0	COG0432@1|root,arCOG04214@2157|Archaea	2157|Archaea	S	PFAM Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
PYH3_k127_2269065_24	410358.Mlab_0946	8.673e-28	122.0	arCOG02879@1|root,arCOG02879@2157|Archaea	2157|Archaea	S	Protein of unknown function (DUF4013)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4013
PYH3_k127_2269065_20	391623.TERMP_01551	4.368e-35	144.0	COG4044@1|root,arCOG04612@2157|Archaea,2XT7E@28890|Euryarchaeota,242Y4@183968|Thermococci	183968|Thermococci	S	Uncharacterized protein conserved in archaea (DUF2110)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2110
PYH3_k127_2269065_16	243232.MJ_0778	4.662e-44	166.0	COG1418@1|root,arCOG01858@2157|Archaea,2XY7Y@28890|Euryarchaeota,23R1B@183939|Methanococci	183939|Methanococci	S	PFAM metal-dependent phosphohydrolase, HD sub domain	-	-	-	ko:K06950	-	-	-	-	ko00000	-	-	-	HD
PYH3_k127_2269065_9	1282876.BAOK01000001_gene3616	4.572e-80	280.0	COG1063@1|root,COG1063@2|Bacteria,1MV9A@1224|Proteobacteria,2TSWA@28211|Alphaproteobacteria,4BSFK@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Alcohol dehydrogenase GroES-like domain	MA20_31690	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
PYH3_k127_2269065_13	1089553.Tph_c27670	1.34e-51	190.0	COG5012@1|root,COG5012@2|Bacteria,1V1P0@1239|Firmicutes,24G08@186801|Clostridia,42FJI@68295|Thermoanaerobacterales	186801|Clostridia	S	Methionine synthase B12-binding module cap domain protein	-	-	2.1.1.13	ko:K00548,ko:K14084	ko00270,ko00450,ko00670,ko00680,ko01100,ko01110,ko01120,ko01200,ko01230,map00270,map00450,map00670,map00680,map01100,map01110,map01120,map01200,map01230	M00017,M00563	R00946,R09124,R09365	RC00035,RC00113,RC00732,RC01241,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2
PYH3_k127_2269065_18	195522.BD01_1951	6.524e-40	154.0	COG1675@1|root,arCOG04270@2157|Archaea,2XSWK@28890|Euryarchaeota,2438P@183968|Thermococci	183968|Thermococci	K	Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes	tfe	-	-	ko:K03136	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIE_alpha
PYH3_k127_2269065_12	415426.Hbut_1137	4.826e-53	192.0	COG1303@1|root,arCOG01857@2157|Archaea,2XQAA@28889|Crenarchaeota	28889|Crenarchaeota	J	Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs	-	-	2.1.1.206	ko:K07254	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Trm56
PYH3_k127_2269065_26	1094980.Mpsy_2073	1.274e-19	95.0	COG1813@1|root,arCOG01863@2157|Archaea,2XYZ0@28890|Euryarchaeota,2N9WA@224756|Methanomicrobia	224756|Methanomicrobia	K	Helix-turn-helix domain protein	-	-	-	ko:K03627	-	-	-	-	ko00000	-	-	-	HTH_3
PYH3_k127_2269065_22	572546.Arcpr_0261	1.607e-31	129.0	COG1370@1|root,arCOG00991@2157|Archaea,2XYFT@28890|Euryarchaeota,2471G@183980|Archaeoglobi	183980|Archaeoglobi	O	PUA domain containing protein	-	-	-	ko:K07398	-	-	-	-	ko00000	-	-	-	PUA,TGT_C2
PYH3_k127_2269065_28	1120949.KB903316_gene74	2.854e-10	73.0	COG1404@1|root,COG3506@1|root,COG1404@2|Bacteria,COG3506@2|Bacteria,2I8MD@201174|Actinobacteria,4DM2S@85008|Micromonosporales	201174|Actinobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Peptidase_S8,SLH,fn3_5
PYH3_k127_2269065_14	693661.Arcve_1732	2.955e-50	203.0	COG1131@1|root,arCOG00194@2157|Archaea,2XUK9@28890|Euryarchaeota	28890|Euryarchaeota	E	COG1131 ABC-type multidrug transport system ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
PYH3_k127_2269065_21	877455.Metbo_2057	2.398e-33	143.0	COG0842@1|root,arCOG01463@2157|Archaea,2XWB7@28890|Euryarchaeota,23PY9@183925|Methanobacteria	183925|Methanobacteria	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
PYH3_k127_2269065_30	272557.APE_0198.1	3.122e-06	55.0	COG1308@1|root,arCOG04061@2157|Archaea,2XR2D@28889|Crenarchaeota	28889|Crenarchaeota	J	Contacts the emerging nascent chain on the ribosome	nac	-	-	ko:K03626	-	-	-	-	ko00000	-	-	-	NAC
PYH3_k127_2269065_17	529709.PYCH_15760	7.332e-41	158.0	COG1394@1|root,arCOG04101@2157|Archaea,2XTQ5@28890|Euryarchaeota,242NT@183968|Thermococci	183968|Thermococci	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpD	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
PYH3_k127_2269065_1	342949.PNA2_0837	4.125e-226	707.0	COG1156@1|root,arCOG00865@2157|Archaea,2XSYQ@28890|Euryarchaeota,2433N@183968|Thermococci	183968|Thermococci	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit	atpB	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
PYH3_k127_2269065_0	868131.MSWAN_1972	3.905e-242	762.0	COG1155@1|root,arCOG00868@2157|Archaea,2XT8I@28890|Euryarchaeota,23NK7@183925|Methanobacteria	183925|Methanobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit	atpA	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
PYH3_k127_2269065_8	1121472.AQWN01000007_gene1075	1.914e-90	309.0	COG2309@1|root,COG2309@2|Bacteria,1UMYG@1239|Firmicutes,24BYI@186801|Clostridia,266UN@186807|Peptococcaceae	186801|Clostridia	E	Thermophilic metalloprotease (M29)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M29
PYH3_k127_2269065_29	543526.Htur_2542	2.548e-08	62.0	COG1992@1|root,arCOG00021@2157|Archaea,2XTP7@28890|Euryarchaeota,23SNG@183963|Halobacteria	183963|Halobacteria	H	Transcriptional regulator	thiN2	-	-	ko:K22206	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3,ThiP_synth
PYH3_k127_2269065_27	1121413.JMKT01000011_gene2391	5.864e-13	70.0	COG4231@1|root,COG4231@2|Bacteria,1N6WI@1224|Proteobacteria,42V3I@68525|delta/epsilon subdivisions,2WRKA@28221|Deltaproteobacteria,2MD6W@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM 4Fe-4S ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
PYH3_k127_2269065_6	1408303.JNJJ01000046_gene980	1.906e-106	358.0	COG0436@1|root,COG0436@2|Bacteria,1TP0J@1239|Firmicutes,4IMZ2@91061|Bacilli,1ZM9X@1386|Bacillus	91061|Bacilli	E	DegT/DnrJ/EryC1/StrS aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
PYH3_k127_2269065_4	218284.CCDN010000001_gene315	4.74e-110	369.0	COG1473@1|root,COG1473@2|Bacteria,1TQ7B@1239|Firmicutes,4HAIK@91061|Bacilli,1ZDIH@1386|Bacillus	91061|Bacilli	S	amidohydrolase	hmrA	-	-	ko:K21613	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
PYH3_k127_2269065_25	1499967.BAYZ01000009_gene5283	3.342e-21	93.0	COG1773@1|root,COG1773@2|Bacteria,2NS28@2323|unclassified Bacteria	2|Bacteria	C	Rubredoxin	rub	-	-	-	-	-	-	-	-	-	-	-	Rubredoxin
PYH3_k127_2269065_15	515635.Dtur_0260	2.144e-47	177.0	COG1014@1|root,COG1014@2|Bacteria	2|Bacteria	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	porC	-	1.2.7.1	ko:K00172	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
PYH3_k127_2269065_23	985053.VMUT_0348	1.136e-28	119.0	COG1144@1|root,arCOG01604@2157|Archaea,2XQU1@28889|Crenarchaeota	28889|Crenarchaeota	C	TIGRFAM 2-oxoacid acceptor oxidoreductase, delta subunit, pyruvate 2-ketoisovalerate family	-	-	1.2.7.1	ko:K00171	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4
PYH3_k127_2269065_3	926561.KB900617_gene2305	4.057e-120	399.0	COG0674@1|root,COG0674@2|Bacteria,1VS48@1239|Firmicutes,25E5U@186801|Clostridia,3WAF8@53433|Halanaerobiales	186801|Clostridia	C	PFAM Pyruvate flavodoxin ferredoxin oxidoreductase	porA	-	1.2.7.1	ko:K00169	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
PYH3_k127_2269065_5	368408.Tpen_0574	1.661e-106	353.0	COG1013@1|root,arCOG01601@2157|Archaea,2XPQR@28889|Crenarchaeota	28889|Crenarchaeota	C	PFAM Thiamine pyrophosphate	-	-	1.2.7.1	ko:K00170	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
PYH3_k127_2269065_19	1121422.AUMW01000002_gene2121	2.162e-37	144.0	COG1917@1|root,COG1917@2|Bacteria,1UHAE@1239|Firmicutes,24C81@186801|Clostridia	186801|Clostridia	S	Cupin domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
PYH3_k127_2269065_10	1094980.Mpsy_1503	4.55e-73	254.0	COG1122@1|root,arCOG00203@2157|Archaea,2Y7N4@28890|Euryarchaeota	28890|Euryarchaeota	P	part of an ABC transporter complex. Responsible for energy coupling to the transport system	ecfA	-	-	ko:K02006	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	ABC_tran
PYH3_k127_2302485_4	1365176.N186_01960	2.018e-55	201.0	COG0081@1|root,arCOG04289@2157|Archaea,2XQ8W@28889|Crenarchaeota	28889|Crenarchaeota	J	Binds directly to 23S rRNA. Probably involved in E site tRNA release	rpl1	GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
PYH3_k127_2302485_3	1459636.NTE_00712	6.238e-61	220.0	COG0244@1|root,arCOG04288@2157|Archaea,41S9R@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rpl10	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
PYH3_k127_2302485_5	933801.Ahos_1298	1.672e-19	91.0	COG2058@1|root,arCOG04287@2157|Archaea,2XQSC@28889|Crenarchaeota	28889|Crenarchaeota	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rpl12	GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02869	ko03010,map03010	M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_60s
PYH3_k127_2302485_1	529709.PYCH_13670	3.045e-243	782.0	COG0013@1|root,arCOG01255@2157|Archaea,2XSXB@28890|Euryarchaeota,243PB@183968|Thermococci	183968|Thermococci	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	GO:0000049,GO:0002161,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0097159,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
PYH3_k127_2302485_0	1041930.Mtc_2296	2.136e-267	853.0	COG0495@1|root,arCOG00809@2157|Archaea,2XU7M@28890|Euryarchaeota,2N99R@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1g
PYH3_k127_2302485_2	289376.THEYE_A1153	8.862e-124	403.0	COG0115@1|root,COG0115@2|Bacteria,3J0BM@40117|Nitrospirae	40117|Nitrospirae	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
PYH3_k127_2302485_6	1006006.Mcup_0847	2.038e-12	68.0	COG1720@1|root,arCOG00761@2157|Archaea,2XS09@28889|Crenarchaeota	28889|Crenarchaeota	S	Uncharacterised protein family UPF0066	-	-	-	-	-	-	-	-	-	-	-	-	UPF0066
PYH3_k127_2368422_2	304371.MCP_0978	1.035e-31	128.0	COG2146@1|root,arCOG02852@2157|Archaea,2Y74T@28890|Euryarchaeota,2NBB7@224756|Methanomicrobia	224756|Methanomicrobia	P	Rieske 2Fe-2S	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
PYH3_k127_2368422_0	304371.MCP_0977	1.427e-50	181.0	COG4802@1|root,arCOG01099@2157|Archaea,2Y47M@28890|Euryarchaeota,2NB0P@224756|Methanomicrobia	224756|Methanomicrobia	C	Ferredoxin thioredoxin reductase catalytic beta chain	-	-	-	-	-	-	-	-	-	-	-	-	FeThRed_B
PYH3_k127_2368422_4	304371.MCP_0976	8.232e-27	111.0	COG0695@1|root,arCOG02606@2157|Archaea,2Y25G@28890|Euryarchaeota	28890|Euryarchaeota	O	Glutaredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Glutaredoxin
PYH3_k127_2368422_1	304371.MCP_0975	7.906e-35	135.0	COG2146@1|root,arCOG02852@2157|Archaea,2Y72M@28890|Euryarchaeota,2NB71@224756|Methanomicrobia	224756|Methanomicrobia	P	Rieske-like [2Fe-2S] domain	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
PYH3_k127_2368422_5	521011.Mpal_2600	7.306e-18	91.0	COG1970@1|root,arCOG05213@2157|Archaea,2XZ6U@28890|Euryarchaeota,2N9XV@224756|Methanomicrobia	224756|Methanomicrobia	M	Large-conductance mechanosensitive channel, MscL	-	-	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
PYH3_k127_2368422_3	370438.PTH_1653	1.365e-29	120.0	COG1254@1|root,COG1254@2|Bacteria,1VC7N@1239|Firmicutes,259HS@186801|Clostridia,2633Z@186807|Peptococcaceae	186801|Clostridia	C	Acylphosphatase	-	-	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	-	R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000	-	-	-	Acylphosphatase
PYH3_k127_2495402_5	123214.PERMA_1932	1.951e-18	87.0	COG2005@1|root,COG2005@2|Bacteria	2|Bacteria	P	Transcriptional regulator	modE	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0042802,GO:0044424,GO:0044444,GO:0044464	-	ko:K02019,ko:K05772	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000,ko03000	3.A.1.6.2,3.A.1.6.4	-	-	HTH_1,TOBE
PYH3_k127_2495402_7	1229909.NSED_08930	3.664e-10	72.0	arCOG10597@1|root,arCOG10597@2157|Archaea	2157|Archaea	O	serine-type endopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_2495402_8	1121342.AUCO01000002_gene824	3.06e-07	64.0	2CC4I@1|root,2Z8PZ@2|Bacteria,1TQTT@1239|Firmicutes,24AJ3@186801|Clostridia,36F6T@31979|Clostridiaceae	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_2495402_2	443143.GM18_4304	2.138e-69	248.0	COG2006@1|root,COG2006@2|Bacteria,1QMGX@1224|Proteobacteria,42PRJ@68525|delta/epsilon subdivisions,2WMFN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
PYH3_k127_2495402_0	56780.SYN_02058	8.723e-99	342.0	COG0348@1|root,COG1143@1|root,COG1245@1|root,COG0348@2|Bacteria,COG1143@2|Bacteria,COG1245@2|Bacteria,1MY5M@1224|Proteobacteria,43BPV@68525|delta/epsilon subdivisions,2WJVS@28221|Deltaproteobacteria,2MSKF@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_5,Fer4_7
PYH3_k127_2495402_4	1165841.SULAR_02623	2.718e-26	112.0	COG1051@1|root,COG1051@2|Bacteria,1QUM0@1224|Proteobacteria,42SY6@68525|delta/epsilon subdivisions,2YPEG@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	F	ADP-ribose pyrophosphatase	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
PYH3_k127_2495402_3	273057.SSO1591	1.897e-34	142.0	arCOG05339@1|root,arCOG05339@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_2495402_1	1229909.NSED_02970	1.226e-74	259.0	COG0412@1|root,arCOG10350@1|root,arCOG01659@2157|Archaea,arCOG10350@2157|Archaea,41T1E@651137|Thaumarchaeota	651137|Thaumarchaeota	Q	Chlorophyllase	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
PYH3_k127_2495402_6	1054213.HMPREF9946_02468	3.361e-16	83.0	COG0346@1|root,COG0346@2|Bacteria,1RCYX@1224|Proteobacteria,2U7A8@28211|Alphaproteobacteria,2JS47@204441|Rhodospirillales	204441|Rhodospirillales	E	Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione	-	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
PYH3_k127_2524925_4	591019.Shell_1403	2.347e-25	112.0	arCOG00022@1|root,arCOG00022@2157|Archaea,2XQTH@28889|Crenarchaeota	28889|Crenarchaeota	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
PYH3_k127_2524925_0	1121405.dsmv_2802	4.675e-149	476.0	COG0039@1|root,COG0039@2|Bacteria,1MV57@1224|Proteobacteria,42KZJ@68525|delta/epsilon subdivisions,2WJ4U@28221|Deltaproteobacteria,2MJ7T@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	-	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
PYH3_k127_2524925_1	572546.Arcpr_1849	1.051e-139	456.0	COG0281@1|root,arCOG00853@2157|Archaea,2XSTN@28890|Euryarchaeota,246RP@183980|Archaeoglobi	183980|Archaeoglobi	C	Malic enzyme, NAD binding domain	-	-	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	-	R00214	RC00105	ko00000,ko00001,ko01000	-	-	-	Malic_M,malic
PYH3_k127_2524925_6	247156.NFA_51250	3.141e-06	53.0	COG0346@1|root,COG0346@2|Bacteria,2IG0S@201174|Actinobacteria,4G0ZN@85025|Nocardiaceae	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
PYH3_k127_2524925_3	1220534.B655_1291	5.541e-40	154.0	COG0778@1|root,arCOG00288@2157|Archaea,2XZHP@28890|Euryarchaeota	28890|Euryarchaeota	C	Putative TM nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase,TM1586_NiRdase
PYH3_k127_2524925_2	374847.Kcr_0400	9.558e-110	366.0	COG1759@1|root,arCOG04346@2157|Archaea	2157|Archaea	F	Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'- monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1- beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates	purP	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016874,GO:0016879,GO:0016881,GO:0043774,GO:0044424,GO:0044464	6.3.4.23	ko:K06863	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R06975	RC00263,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1246,DUF1297
PYH3_k127_2524925_5	1229909.NSED_04285	1.711e-10	62.0	COG1759@1|root,arCOG04346@2157|Archaea,41S79@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Domain of unknown function (DUF1297)	-	-	6.3.4.23	ko:K06863	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R06975	RC00263,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1246,DUF1297
PYH3_k127_2610182_3	45351.EDO47192	1.336e-05	48.0	COG1896@1|root,KOG3197@2759|Eukaryota,38FZH@33154|Opisthokonta,3BIBA@33208|Metazoa	33208|Metazoa	S	HD domain	HDDC2	GO:0008150,GO:0030431,GO:0032501	-	ko:K07023	-	-	-	-	ko00000	-	-	-	HD_3
PYH3_k127_2610182_0	386456.JQKN01000002_gene2748	1.248e-127	420.0	COG1503@1|root,arCOG01742@2157|Archaea,2XSV5@28890|Euryarchaeota,23NWK@183925|Methanobacteria	183925|Methanobacteria	J	Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA	prf1	-	-	ko:K03265	ko03015,map03015	-	-	-	ko00000,ko00001,ko03012,ko03019	-	-	-	eRF1_1,eRF1_2,eRF1_3
PYH3_k127_2610182_2	243231.GSU0773	1.407e-18	98.0	COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,42NA4@68525|delta/epsilon subdivisions,2WKTU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	EGP	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
PYH3_k127_2610182_1	1220534.B655_0165	9.073e-55	199.0	COG0528@1|root,arCOG00858@2157|Archaea,2XT3U@28890|Euryarchaeota,23NRI@183925|Methanobacteria	183925|Methanobacteria	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
PYH3_k127_2656681_1	572546.Arcpr_0277	2.215e-05	55.0	COG1989@1|root,arCOG02298@2157|Archaea,2XUQP@28890|Euryarchaeota,24693@183980|Archaeoglobi	183980|Archaeoglobi	N	Peptidase A24B, FlaK domain protein	-	-	3.4.23.52	ko:K07991	-	-	-	-	ko00000,ko01000,ko01002,ko02035,ko02044	-	-	-	Arc_PepC_II,Peptidase_A24
PYH3_k127_2656681_0	523850.TON_0889	1.705e-38	153.0	COG0467@1|root,arCOG01171@2157|Archaea,2Y7MI@28890|Euryarchaeota,243IW@183968|Thermococci	183968|Thermococci	T	KaiC	-	-	-	-	-	-	-	-	-	-	-	-	ATPase
PYH3_k127_2706821_42	401526.TcarDRAFT_0297	1.6e-39	156.0	COG2045@1|root,COG2045@2|Bacteria,1V56I@1239|Firmicutes,4H464@909932|Negativicutes	909932|Negativicutes	H	Belongs to the ComB family	comB	-	3.1.3.71	ko:K05979	ko00680,ko01120,map00680,map01120	M00358	R05789	RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	2-ph_phosp
PYH3_k127_2706821_8	386456.JQKN01000002_gene2571	1.745e-145	475.0	COG1964@1|root,arCOG00933@2157|Archaea,2XTMK@28890|Euryarchaeota,23NK2@183925|Methanobacteria	183925|Methanobacteria	S	4Fe-4S single cluster domain	-	-	-	ko:K06937	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
PYH3_k127_2706821_30	1459636.NTE_00618	1.852e-70	243.0	COG2101@1|root,arCOG01764@2157|Archaea,41SZD@651137|Thaumarchaeota	651137|Thaumarchaeota	K	General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation	-	-	-	ko:K03120	ko03022,ko05016,ko05165,ko05166,ko05168,ko05169,ko05203,map03022,map05016,map05165,map05166,map05168,map05169,map05203	-	-	-	ko00000,ko00001,ko03000,ko03021	-	-	-	TBP
PYH3_k127_2706821_76	490899.DKAM_0885	6.491e-08	61.0	COG0681@1|root,arCOG01739@2157|Archaea	2157|Archaea	U	Signal peptidase	-	GO:0003674,GO:0003824,GO:0006465,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0010467,GO:0016485,GO:0016787,GO:0019538,GO:0034641,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:0140096,GO:1901564	3.4.21.89	ko:K13280	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
PYH3_k127_2706821_66	536227.CcarbDRAFT_5112	1.056e-13	76.0	COG1695@1|root,COG1695@2|Bacteria,1VA94@1239|Firmicutes,24PWU@186801|Clostridia,36KKH@31979|Clostridiaceae	186801|Clostridia	K	transcriptional regulator PadR family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
PYH3_k127_2706821_26	1385511.N783_02050	2.243e-80	279.0	COG1063@1|root,COG1063@2|Bacteria,1TS6I@1239|Firmicutes,4HD08@91061|Bacilli,2Y9HK@289201|Pontibacillus	91061|Bacilli	E	Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate	tdh	-	1.1.1.103	ko:K00060	ko00260,map00260	-	R01465	RC00525	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
PYH3_k127_2706821_12	484770.UFO1_3738	2.225e-117	389.0	COG1995@1|root,COG1995@2|Bacteria,1TQGT@1239|Firmicutes,4H3IP@909932|Negativicutes	909932|Negativicutes	H	Belongs to the PdxA family	-	-	1.1.1.408,1.1.1.409	ko:K22024	-	-	-	-	ko00000,ko01000	-	-	-	PdxA
PYH3_k127_2706821_22	748449.Halha_1188	2.261e-86	301.0	COG3395@1|root,COG3395@2|Bacteria,1TPNP@1239|Firmicutes,24AJF@186801|Clostridia,3WBXK@53433|Halanaerobiales	186801|Clostridia	S	Putative nucleotide-binding of sugar-metabolising enzyme	-	-	2.7.1.219,2.7.1.220	ko:K22129	-	-	-	-	ko00000,ko01000	-	-	-	DUF1357_C,DUF1537
PYH3_k127_2706821_46	273116.14325081	1.613e-36	145.0	COG2220@1|root,arCOG00497@2157|Archaea,2XTCN@28890|Euryarchaeota,241XY@183967|Thermoplasmata	183967|Thermoplasmata	S	hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
PYH3_k127_2706821_34	1094508.Tsac_0624	8.363e-55	203.0	COG1208@1|root,COG1208@2|Bacteria,1VDBC@1239|Firmicutes,24AGU@186801|Clostridia,42EZG@68295|Thermoanaerobacterales	186801|Clostridia	M	Transferase hexapeptide repeat	-	-	2.7.7.13	ko:K00966	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
PYH3_k127_2706821_73	926554.KI912653_gene4149	5.022e-10	72.0	2EZGX@1|root,2ZBAK@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_2706821_55	502558.EGYY_10820	4.012e-27	125.0	COG3875@1|root,COG3875@2|Bacteria,2I9JU@201174|Actinobacteria,4CVYU@84998|Coriobacteriia	84998|Coriobacteriia	S	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
PYH3_k127_2706821_39	1459636.NTE_00615	6.819e-47	176.0	COG0461@1|root,arCOG00029@2157|Archaea,41SJU@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
PYH3_k127_2706821_59	1410676.JNKL01000013_gene1940	2.73e-23	114.0	COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,1RPZS@1236|Gammaproteobacteria,1Y3K1@135624|Aeromonadales	135624|Aeromonadales	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
PYH3_k127_2706821_19	693661.Arcve_0243	1.318e-91	318.0	COG0303@1|root,arCOG00217@2157|Archaea,2Y7W9@28890|Euryarchaeota,247I1@183980|Archaeoglobi	183980|Archaeoglobi	H	Molybdenum cofactor synthesis domain protein	-	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
PYH3_k127_2706821_1	397948.Cmaq_0710	1.985e-201	644.0	COG2414@1|root,arCOG00706@2157|Archaea,2XQ6E@28889|Crenarchaeota	28889|Crenarchaeota	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
PYH3_k127_2706821_31	397948.Cmaq_0711	6.989e-59	211.0	COG0235@1|root,arCOG04226@2157|Archaea,2XQGF@28889|Crenarchaeota	28889|Crenarchaeota	G	Class II aldolase adducin family protein	-	-	4.1.2.17	ko:K01628	ko00051,ko01120,map00051,map01120	-	R02262	RC00603,RC00604	ko00000,ko00001,ko01000	-	-	-	Aldolase_II
PYH3_k127_2706821_14	1094980.Mpsy_1639	2.883e-116	386.0	COG0183@1|root,arCOG01278@2157|Archaea,2XT38@28890|Euryarchaeota,2N94P@224756|Methanomicrobia	224756|Methanomicrobia	I	PFAM Thiolase	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iAF692.Mbar_A0550	Thiolase_C,Thiolase_N
PYH3_k127_2706821_61	573064.Mefer_1486	1.256e-20	96.0	COG1545@1|root,arCOG01285@2157|Archaea,2XXGF@28890|Euryarchaeota,23QWX@183939|Methanococci	183939|Methanococci	V	DUF35 OB-fold domain, acyl-CoA-associated	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
PYH3_k127_2706821_43	342949.PNA2_0706	1.797e-39	157.0	COG0467@1|root,arCOG01171@2157|Archaea,2Y7MQ@28890|Euryarchaeota,243HH@183968|Thermococci	183968|Thermococci	T	KaiC	-	-	-	-	-	-	-	-	-	-	-	-	ATPase
PYH3_k127_2706821_0	1365176.N186_05140	1.883e-220	699.0	COG0441@1|root,arCOG00401@2157|Archaea,2XQ02@28889|Crenarchaeota	28889|Crenarchaeota	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr)	thrS	GO:0002161,GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-Thr_ED,tRNA-synt_2b
PYH3_k127_2706821_70	1459636.NTE_00679	4.237e-11	65.0	arCOG05330@1|root,arCOG05330@2157|Archaea,41SUC@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_2706821_54	1220534.B655_0542	2.527e-27	119.0	COG0558@1|root,arCOG00670@2157|Archaea,2XWJ0@28890|Euryarchaeota,23P32@183925|Methanobacteria	183925|Methanobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.39	ko:K17884	-	-	R10464	RC00002,RC00078	ko00000,ko01000	-	-	-	CDP-OH_P_transf
PYH3_k127_2706821_53	1229909.NSED_05155	4.646e-28	115.0	COG4830@1|root,arCOG04305@2157|Archaea,41SNM@651137|Thaumarchaeota	651137|Thaumarchaeota	J	ribosomal protein	-	-	-	ko:K02976	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S26e
PYH3_k127_2706821_3	1459636.NTE_01640	3.338e-196	622.0	COG0008@1|root,arCOG00402@2157|Archaea,41SFI@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro)	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,ProRS-C_1,tRNA-synt_2b
PYH3_k127_2706821_10	1379698.RBG1_1C00001G1833	1.056e-121	403.0	COG1379@1|root,COG1379@2|Bacteria,2NNW8@2323|unclassified Bacteria	2|Bacteria	L	DNA helicase	yqxK	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DUF4178,PHP_C,UvrD-helicase,UvrD_C
PYH3_k127_2706821_60	399550.Smar_1276	5.451e-21	100.0	arCOG04054@1|root,arCOG04054@2157|Archaea,2XPUY@28889|Crenarchaeota	28889|Crenarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PRC
PYH3_k127_2706821_52	1163730.FFONT_0132	3.182e-29	124.0	COG5491@1|root,arCOG00452@2157|Archaea,2XQBW@28889|Crenarchaeota	28889|Crenarchaeota	D	Conserved protein implicated in secretion	-	-	-	-	-	-	-	-	-	-	-	-	Snf7
PYH3_k127_2706821_36	1408323.JQKK01000007_gene696	1.976e-48	183.0	COG1136@1|root,COG1136@2|Bacteria,1TP6H@1239|Firmicutes,247JJ@186801|Clostridia,27IAJ@186928|unclassified Lachnospiraceae	186801|Clostridia	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
PYH3_k127_2706821_77	1536770.R50345_03650	9.634e-07	57.0	COG1522@1|root,COG1522@2|Bacteria,1V45K@1239|Firmicutes,4HH2H@91061|Bacilli,26YRG@186822|Paenibacillaceae	91061|Bacilli	K	transcriptional	lrpB	GO:0001101,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010033,GO:0010243,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0042221,GO:0043200,GO:0043565,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1901698,GO:1901700,GO:1903506,GO:2000112,GO:2001141	-	ko:K03719	-	-	-	-	ko00000,ko03000,ko03036	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
PYH3_k127_2706821_11	1459636.NTE_03020	5.859e-121	399.0	COG0464@1|root,arCOG01307@2157|Archaea,41SA4@651137|Thaumarchaeota	651137|Thaumarchaeota	D	AAA domain (Cdc48 subfamily)	-	-	-	-	-	-	-	-	-	-	-	-	AAA,MIT,Vps4_C
PYH3_k127_2706821_58	1006006.Mcup_0109	6.943e-25	114.0	COG5491@1|root,arCOG00452@2157|Archaea,2XQBW@28889|Crenarchaeota	28889|Crenarchaeota	D	Conserved protein implicated in secretion	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_2706821_64	1184251.TCELL_0036	1.615e-17	91.0	arCOG04054@1|root,arCOG04054@2157|Archaea,2XPUY@28889|Crenarchaeota	28889|Crenarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PRC
PYH3_k127_2706821_44	930945.SiRe_1200	7.14e-39	155.0	COG5491@1|root,arCOG00452@2157|Archaea,2XQBW@28889|Crenarchaeota	28889|Crenarchaeota	D	Conserved protein implicated in secretion	-	-	-	-	-	-	-	-	-	-	-	-	Snf7
PYH3_k127_2706821_56	933262.AXAM01000005_gene2471	1.122e-26	113.0	COG1545@1|root,COG1545@2|Bacteria,1NPAR@1224|Proteobacteria,42WW8@68525|delta/epsilon subdivisions,2WSYD@28221|Deltaproteobacteria,2MM8Q@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Rubredoxin-like zinc ribbon domain (DUF35_N)	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
PYH3_k127_2706821_38	1041930.Mtc_1046	3.555e-47	176.0	COG0529@1|root,arCOG01040@2157|Archaea,2XU4H@28890|Euryarchaeota,2NBDX@224756|Methanomicrobia	224756|Methanomicrobia	P	Adenylylsulphate kinase	cysC	-	2.7.1.25	ko:K00860	ko00230,ko00920,ko01100,ko01120,map00230,map00920,map01100,map01120	M00176	R00509,R04928	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase
PYH3_k127_2706821_27	1041930.Mtc_1045	6.546e-75	265.0	arCOG01186@1|root,arCOG01186@2157|Archaea	2157|Archaea	G	Mn2 dependent serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	APH
PYH3_k127_2706821_6	289376.THEYE_A0111	6.349e-170	542.0	COG0499@1|root,COG0499@2|Bacteria,3J0AH@40117|Nitrospirae	40117|Nitrospirae	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
PYH3_k127_2706821_5	391623.TERMP_00216	2.604e-173	562.0	COG0008@1|root,arCOG04302@2157|Archaea,2XSYV@28890|Euryarchaeota,242MB@183968|Thermococci	183968|Thermococci	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
PYH3_k127_2706821_24	439481.Aboo_1203	6.406e-84	288.0	COG2896@1|root,arCOG00930@2157|Archaea,2XT7P@28890|Euryarchaeota,3F33B@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Mob_synth_C,Radical_SAM
PYH3_k127_2706821_45	368408.Tpen_0312	1.464e-38	151.0	COG0521@1|root,arCOG00214@2157|Archaea,2XQH2@28889|Crenarchaeota	28889|Crenarchaeota	H	TIGRFAM molybdenum cofactor synthesis domain	moaB	-	2.7.7.75	ko:K03638	ko00790,ko01100,map00790,map01100	-	R09726	RC00002	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth
PYH3_k127_2706821_41	272844.PAB2103	3.634e-41	157.0	COG0315@1|root,arCOG01530@2157|Archaea,2XWHQ@28890|Euryarchaeota,243UY@183968|Thermococci	183968|Thermococci	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
PYH3_k127_2706821_71	1459636.NTE_01448	7.052e-11	70.0	arCOG08765@1|root,arCOG08765@2157|Archaea	1459636.NTE_01448|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_2706821_20	391623.TERMP_00481	1.163e-88	303.0	COG0309@1|root,arCOG00636@2157|Archaea,2XTAH@28890|Euryarchaeota,245CI@183968|Thermococci	183968|Thermococci	O	AIR synthase related protein, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AIRS,AIRS_C
PYH3_k127_2706821_62	1303518.CCALI_02180	5.722e-19	94.0	COG0586@1|root,COG0586@2|Bacteria	2|Bacteria	S	FtsZ-dependent cytokinesis	dedA	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
PYH3_k127_2706821_21	573064.Mefer_0665	2.164e-86	295.0	COG0167@1|root,arCOG00603@2157|Archaea,2XTMB@28890|Euryarchaeota,23QC5@183939|Methanococci	183939|Methanococci	F	Catalyzes the conversion of dihydroorotate to orotate	pyrD	GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	1.3.1.14	ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
PYH3_k127_2706821_18	1056495.Calag_0321	1.111e-99	338.0	COG1498@1|root,arCOG01923@2157|Archaea,2XPYC@28889|Crenarchaeota	28889|Crenarchaeota	J	PFAM Pre-mRNA processing ribonucleoprotein, binding	-	-	-	ko:K14564	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	Nop
PYH3_k127_2706821_29	694429.Pyrfu_0791	1.187e-72	251.0	COG0513@1|root,arCOG00078@2157|Archaea,2XPRR@28889|Crenarchaeota	28889|Crenarchaeota	J	Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA	flpA	GO:0000154,GO:0000494,GO:0001510,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0006139,GO:0006325,GO:0006364,GO:0006396,GO:0006464,GO:0006479,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008213,GO:0008276,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0016074,GO:0016569,GO:0016570,GO:0016571,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0022613,GO:0031123,GO:0031126,GO:0031167,GO:0032259,GO:0033967,GO:0034470,GO:0034641,GO:0034660,GO:0034963,GO:0036009,GO:0036211,GO:0042054,GO:0042254,GO:0043144,GO:0043170,GO:0043412,GO:0043414,GO:0043628,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046483,GO:0051276,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140096,GO:0140098,GO:0140102,GO:1901360,GO:1901363,GO:1901564,GO:1990258,GO:1990259	-	ko:K04795	-	-	-	-	ko00000,ko03009	-	-	-	Fibrillarin
PYH3_k127_2706821_80	186497.PF0452	0.0005322	49.0	COG2083@1|root,arCOG01921@2157|Archaea,2Y13G@28890|Euryarchaeota,244BU@183968|Thermococci	183968|Thermococci	S	Belongs to the UPF0216 family	-	-	-	ko:K09737	-	-	-	-	ko00000	-	-	-	DUF61
PYH3_k127_2706821_40	1183377.Py04_1540	1.965e-46	175.0	COG0164@1|root,arCOG04121@2157|Archaea,2XWYC@28890|Euryarchaeota,242VW@183968|Thermococci	183968|Thermococci	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
PYH3_k127_2706821_48	1365176.N186_06370	8.492e-33	135.0	COG1618@1|root,arCOG01034@2157|Archaea,2XR6D@28889|Crenarchaeota	28889|Crenarchaeota	F	Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency	-	-	3.6.1.15	ko:K06928	ko00230,ko00730,ko01100,map00230,map00730,map01100	-	R00086,R00615	RC00002	ko00000,ko00001,ko01000	-	-	-	NTPase_1
PYH3_k127_2706821_25	1220534.B655_1721	1.926e-82	287.0	COG1867@1|root,arCOG01219@2157|Archaea,2XTUF@28890|Euryarchaeota,23NVN@183925|Methanobacteria	183925|Methanobacteria	J	Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups	trm1	-	2.1.1.215,2.1.1.216	ko:K00555	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TRM
PYH3_k127_2706821_37	416348.Hlac_0434	1.786e-47	177.0	COG0293@1|root,arCOG00079@2157|Archaea,2XT12@28890|Euryarchaeota,23T6V@183963|Halobacteria	183963|Halobacteria	J	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit	rrmJ	-	2.1.1.166	ko:K02427	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ,TRAM
PYH3_k127_2706821_69	1365176.N186_02870	1.525e-11	69.0	COG1522@1|root,arCOG04153@2157|Archaea,2XR1T@28889|Crenarchaeota	28889|Crenarchaeota	K	COG1522 Transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	B-block_TFIIIC,HTH_24,MarR
PYH3_k127_2706821_7	877455.Metbo_1210	6.662e-152	494.0	COG0215@1|root,arCOG00486@2157|Archaea,2XTRY@28890|Euryarchaeota,23NUS@183925|Methanobacteria	183925|Methanobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e,tRNA-synt_1g
PYH3_k127_2706821_32	98439.AJLL01000100_gene502	1.234e-58	210.0	COG1839@1|root,COG1839@2|Bacteria,1G575@1117|Cyanobacteria	1117|Cyanobacteria	S	PFAM Adenosine specific kinase	-	-	-	ko:K09129	-	-	-	-	ko00000	-	-	-	Adenosine_kin
PYH3_k127_2706821_16	933262.AXAM01000005_gene2470	1.31e-109	367.0	COG0183@1|root,COG0183@2|Bacteria,1MU8C@1224|Proteobacteria,42N6X@68525|delta/epsilon subdivisions,2WJIE@28221|Deltaproteobacteria,2MK14@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Thiolase, C-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
PYH3_k127_2706821_15	1236689.MMALV_00330	1.577e-111	368.0	COG1405@1|root,arCOG01981@2157|Archaea,2XT0Z@28890|Euryarchaeota,3F2FH@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	tfb	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
PYH3_k127_2706821_68	186497.PF1791	1.692e-13	72.0	COG3277@1|root,arCOG02466@2157|Archaea,2Y1T0@28890|Euryarchaeota,244GS@183968|Thermococci	183968|Thermococci	J	H ACA RNA-protein complex	-	-	-	ko:K07569	-	-	-	-	ko00000,ko03009	-	-	-	Gar1
PYH3_k127_2706821_4	693661.Arcve_0242	1.883e-195	629.0	COG0303@1|root,COG1910@1|root,arCOG00217@2157|Archaea,arCOG00230@2157|Archaea,2XT2V@28890|Euryarchaeota,245ZM@183980|Archaeoglobi	183980|Archaeoglobi	H	Molybdenum cofactor synthesis domain protein	-	-	2.10.1.1	ko:K03750,ko:K07219	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N,PBP_like
PYH3_k127_2706821_67	1220534.B655_2369	1.622e-13	74.0	COG1400@1|root,arCOG01217@2157|Archaea,2XYV0@28890|Euryarchaeota,23P73@183925|Methanobacteria	183925|Methanobacteria	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP	srp19	-	-	ko:K03105	ko03060,map03060	-	-	-	ko00000,ko00001,ko02044	3.A.5.7,3.A.5.9	-	-	SRP19
PYH3_k127_2706821_51	644281.MFS40622_1507	2.418e-29	122.0	COG2007@1|root,arCOG04154@2157|Archaea,2XYXX@28890|Euryarchaeota,23R0Z@183939|Methanococci	183939|Methanococci	J	PFAM ribosomal protein S8E	rps8e	GO:0000462,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044085,GO:0044237,GO:0044238,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360,GO:1990904	-	ko:K02995	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8e
PYH3_k127_2706821_57	529709.PYCH_12850	4.18e-26	115.0	COG1386@1|root,arCOG02613@2157|Archaea,2XZ7Q@28890|Euryarchaeota,242WQ@183968|Thermococci	183968|Thermococci	K	Segregation and condensation complex subunit ScpB	-	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
PYH3_k127_2706821_79	268739.Nmlp_1668	0.00026	51.0	COG1354@1|root,arCOG02610@2157|Archaea,2XT0N@28890|Euryarchaeota,23TJC@183963|Halobacteria	183963|Halobacteria	L	chromosome segregation and condensation protein ScpA	scpA	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
PYH3_k127_2706821_9	1183377.Py04_1724	1.597e-138	483.0	COG1196@1|root,arCOG00371@2157|Archaea,2XSVK@28890|Euryarchaeota,242QE@183968|Thermococci	183968|Thermococci	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
PYH3_k127_2706821_23	436308.Nmar_1416	2.522e-86	292.0	COG0020@1|root,arCOG01532@2157|Archaea,41S8J@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids	uppS	-	2.5.1.89	ko:K15888	ko00900,map00900	-	R09730	RC00279,RC02839	ko00000,ko00001,ko01000	-	-	-	Prenyltransf
PYH3_k127_2706821_72	415426.Hbut_1089	1.058e-10	72.0	COG1340@1|root,arCOG01159@2157|Archaea,2XQW7@28889|Crenarchaeota	28889|Crenarchaeota	S	archaeal coiled-coil protein	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_2706821_65	1131266.ARWQ01000008_gene328	4.205e-14	77.0	COG0328@1|root,arCOG02942@2157|Archaea,41SWJ@651137|Thaumarchaeota	651137|Thaumarchaeota	L	RNase H	-	-	3.1.26.4	ko:K03469	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RVT_3
PYH3_k127_2706821_28	195522.BD01_0213	1.796e-73	254.0	COG1042@1|root,arCOG01338@2157|Archaea,2XXCA@28890|Euryarchaeota,2435P@183968|Thermococci	183968|Thermococci	C	ATP-grasp domain	-	-	6.2.1.13	ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5
PYH3_k127_2706821_33	1459636.NTE_02213	7.894e-55	201.0	COG1100@1|root,arCOG01225@2157|Archaea,41T0A@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Conserved hypothetical ATP binding protein	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	ATP_bind_1
PYH3_k127_2706821_35	572478.Vdis_1330	3.793e-51	192.0	COG1058@1|root,arCOG00215@2157|Archaea,2XQA2@28889|Crenarchaeota	28889|Crenarchaeota	S	molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	MoCF_biosynth
PYH3_k127_2706821_78	1392491.JIAE01000001_gene1155	8.419e-05	48.0	COG1996@1|root,COG1996@2|Bacteria,1UI9I@1239|Firmicutes,24IQ4@186801|Clostridia	186801|Clostridia	K	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_2706821_2	694429.Pyrfu_1762	1.821e-196	629.0	COG1245@1|root,arCOG00187@2157|Archaea,2XPQF@28889|Crenarchaeota	28889|Crenarchaeota	E	in RNase L inhibitor, RLI	-	-	-	ko:K06174	-	-	-	-	ko00000,ko03009	-	-	-	ABC_tran,Fer4,Fer4_6,RLI
PYH3_k127_2706821_63	240292.Ava_4069	6.13e-18	93.0	COG1011@1|root,COG1011@2|Bacteria,1GAP5@1117|Cyanobacteria,1HQCC@1161|Nostocales	1117|Cyanobacteria	S	HAD-hyrolase-like	-	-	3.1.3.5	ko:K07025,ko:K08723	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
PYH3_k127_2706821_50	399549.Msed_2121	8.991e-30	129.0	COG1058@1|root,arCOG00215@2157|Archaea,2XQA2@28889|Crenarchaeota	28889|Crenarchaeota	S	molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	MoCF_biosynth
PYH3_k127_2706821_75	1220534.B655_0136	6.053e-09	64.0	COG1617@1|root,arCOG02197@2157|Archaea,2Y789@28890|Euryarchaeota,23P8E@183925|Methanobacteria	183925|Methanobacteria	S	Kinase binding protein CGI-121	-	-	-	ko:K09119	-	-	-	-	ko00000,ko03016	-	-	-	CGI-121
PYH3_k127_2706821_49	436308.Nmar_1428	8.835e-33	133.0	COG1818@1|root,arCOG00084@2157|Archaea,41SNW@651137|Thaumarchaeota	651137|Thaumarchaeota	S	THUMP domain	-	-	-	ko:K06963	-	-	-	-	ko00000,ko03016	-	-	-	THUMP
PYH3_k127_2706821_74	368408.Tpen_0870	1.287e-09	69.0	COG3389@1|root,arCOG04463@2157|Archaea,2XSEQ@28889|Crenarchaeota	28889|Crenarchaeota	S	protein conserved in archaea	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_2706821_13	1459636.NTE_03316	1.027e-116	390.0	COG1236@1|root,arCOG00541@2157|Archaea,41SAJ@651137|Thaumarchaeota	651137|Thaumarchaeota	J	exonuclease of the beta-lactamase fold involved in RNA processing	-	-	-	ko:K07577	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B_6,RMMBL
PYH3_k127_2706821_47	694429.Pyrfu_0097	9.708e-34	139.0	COG1938@1|root,arCOG00347@2157|Archaea,2XPV9@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM PAC2 family	-	-	-	ko:K06869	-	-	-	-	ko00000	-	-	-	PAC2
PYH3_k127_2706821_17	694429.Pyrfu_0098	4.809e-106	361.0	COG0343@1|root,arCOG00989@2157|Archaea,2XPSY@28889|Crenarchaeota	28889|Crenarchaeota	J	Exchanges the guanine residue with 7-cyano-7- deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D- loop) of archaeal tRNAs	tgtA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046116,GO:0046483,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.2.48	ko:K18779	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TGT
PYH3_k127_275872_0	1382358.JHVN01000002_gene2168	2.546e-65	231.0	COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,4HAA6@91061|Bacilli,21W76@150247|Anoxybacillus	91061|Bacilli	IQ	Enoyl-(Acyl carrier protein) reductase	fabG	GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	iYO844.BSU15910	adh_short_C2
PYH3_k127_275872_1	525904.Tter_0136	6.488e-27	128.0	COG0823@1|root,COG0823@2|Bacteria,2NPHZ@2323|unclassified Bacteria	2|Bacteria	U	WD40-like Beta Propeller Repeat	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40
PYH3_k127_2865249_6	1487923.DP73_10845	6.627e-34	134.0	COG0755@1|root,COG0755@2|Bacteria,1V4A6@1239|Firmicutes,24IWH@186801|Clostridia,264K0@186807|Peptococcaceae	186801|Clostridia	O	Cytochrome c assembly protein	-	-	-	ko:K02195	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	Cytochrom_C_asm
PYH3_k127_2865249_7	589924.Ferp_0352	9.086e-26	115.0	COG2386@1|root,arCOG01328@2157|Archaea,2XTAS@28890|Euryarchaeota,2466T@183980|Archaeoglobi	183980|Archaeoglobi	O	ABC-type transport system involved in cytochrome c biogenesis permease component	-	-	-	ko:K02194	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	CcmB
PYH3_k127_2865249_5	1449080.JQMV01000003_gene2173	5.784e-44	168.0	COG4555@1|root,COG4555@2|Bacteria,1WIIB@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	CP	ABC transporter	-	-	3.6.3.7	ko:K09697	ko02010,ko02020,map02010,map02020	M00253	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.115	-	-	ABC_tran
PYH3_k127_2865249_2	1459636.NTE_02820	1.192e-138	453.0	COG0017@1|root,arCOG00406@2157|Archaea,41SBT@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	-	-	6.1.1.23	ko:K09759	ko00970,map00970	M00360	R03647,R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
PYH3_k127_2865249_10	1094980.Mpsy_1324	1.263e-14	77.0	COG0721@1|root,arCOG02726@2157|Archaea,2XYQ0@28890|Euryarchaeota,2N9Z4@224756|Methanomicrobia	224756|Methanomicrobia	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	-	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Glu-tRNAGln
PYH3_k127_2865249_0	748449.Halha_2302	5.506e-166	535.0	COG0154@1|root,COG0154@2|Bacteria,1TP0C@1239|Firmicutes,24911@186801|Clostridia,3WA7Q@53433|Halanaerobiales	186801|Clostridia	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
PYH3_k127_2865249_1	273063.STK_02820	3.883e-150	488.0	COG0064@1|root,arCOG01718@2157|Archaea,2XQ1U@28889|Crenarchaeota	28889|Crenarchaeota	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
PYH3_k127_2865249_8	666510.ASAC_0761	2.984e-25	111.0	COG1599@1|root,arCOG01510@2157|Archaea	2157|Archaea	L	COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins	-	-	3.6.4.12	ko:K03658,ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko01000,ko03000,ko03032,ko03400	-	-	-	PLDc_2,UvrD-helicase,UvrD_C,tRNA_anti-codon
PYH3_k127_2865249_9	351160.RCIX2408	7.142e-22	101.0	COG0314@1|root,arCOG00533@2157|Archaea,2XVFP@28890|Euryarchaeota,2N9H4@224756|Methanomicrobia	224756|Methanomicrobia	H	MoaE protein	mobB	-	2.8.1.12	ko:K03635	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoaE,MobB
PYH3_k127_2865249_3	633148.Tagg_0998	3.336e-80	282.0	COG0144@1|root,arCOG00973@2157|Archaea,arCOG00975@2157|Archaea,2XPN6@28889|Crenarchaeota	28889|Crenarchaeota	J	PFAM Fmu (Sun) domain protein	-	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,PUA
PYH3_k127_2865249_4	926692.AZYG01000086_gene736	9.01e-52	192.0	COG1030@1|root,COG1030@2|Bacteria,1V6UR@1239|Firmicutes,24D2S@186801|Clostridia,3WBYU@53433|Halanaerobiales	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	TspO_MBR
PYH3_k127_2885195_13	1160137.KB907307_gene1402	1.231e-39	157.0	COG1402@1|root,COG1402@2|Bacteria,2HCRK@201174|Actinobacteria,4G0CR@85025|Nocardiaceae	201174|Actinobacteria	S	Creatinine amidohydrolase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
PYH3_k127_2885195_0	436308.Nmar_0067	5.763e-266	848.0	COG1615@1|root,arCOG06128@2157|Archaea,41SCS@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Uncharacterised protein family (UPF0182)	-	-	-	ko:K09118	-	-	-	-	ko00000	-	-	-	UPF0182
PYH3_k127_2885195_18	1229909.NSED_07725	2.897e-11	70.0	arCOG01841@1|root,arCOG01841@2157|Archaea,41SPP@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_2885195_16	985053.VMUT_2051	8.358e-26	110.0	COG1324@1|root,arCOG04231@2157|Archaea,2XR9J@28889|Crenarchaeota	28889|Crenarchaeota	P	PFAM CutA1 divalent ion tolerance protein	-	-	-	ko:K03926	-	-	-	-	ko00000	-	-	-	CutA1
PYH3_k127_2885195_17	547559.Nmag_1532	6.785e-16	83.0	COG1310@1|root,arCOG01138@2157|Archaea,2XXA9@28890|Euryarchaeota,23VWD@183963|Halobacteria	183963|Halobacteria	S	metal-dependent protease of the PAD1 JAB1 superfamily	jamm1	-	3.4.19.15	ko:K20110	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Prok-JAB
PYH3_k127_2885195_8	1459636.NTE_00019	2.816e-56	214.0	COG0527@1|root,arCOG00861@2157|Archaea,41SFK@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Amino acid kinase family	-	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
PYH3_k127_2885195_19	416348.Hlac_3545	1.162e-08	67.0	COG0517@1|root,arCOG00601@2157|Archaea,2XVRW@28890|Euryarchaeota,23S35@183963|Halobacteria	183963|Halobacteria	S	COG0517 FOG CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
PYH3_k127_2885195_4	1281779.H009_16621	8.481e-71	253.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQMJ@28211|Alphaproteobacteria,4BAI9@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Belongs to the ABC transporter superfamily	potA-1	-	-	ko:K02052	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	ABC_tran,TOBE_2
PYH3_k127_2885195_6	351160.RCIX1623	4.102e-69	243.0	COG0555@1|root,arCOG00164@2157|Archaea,2XVJ4@28890|Euryarchaeota,2N9S1@224756|Methanomicrobia	224756|Methanomicrobia	P	PFAM binding-protein-dependent transport systems inner membrane component	modB	-	-	ko:K02018	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	BPD_transp_1
PYH3_k127_2885195_14	351160.RCIX1621	1.442e-39	158.0	COG0725@1|root,arCOG00219@2157|Archaea,2XWT8@28890|Euryarchaeota,2N9WQ@224756|Methanomicrobia	224756|Methanomicrobia	P	TIGRFAM molybdenum ABC transporter, periplasmic molybdate-binding protein	modA	-	-	ko:K02020	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	SBP_bac_11
PYH3_k127_2885195_7	374847.Kcr_0043	4.605e-57	211.0	COG0611@1|root,arCOG00638@2157|Archaea	2157|Archaea	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0006725,GO:0006732,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009030,GO:0009058,GO:0009108,GO:0009229,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0018130,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0035639,GO:0036094,GO:0042357,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0046483,GO:0046983,GO:0051186,GO:0051188,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
PYH3_k127_2885195_3	374847.Kcr_0960	4.583e-71	247.0	COG0013@1|root,arCOG01254@2157|Archaea	2157|Archaea	J	Related to alanyl-tRNA synthetase HxxxH domain	alaXM	GO:0002161,GO:0003674,GO:0003824,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360	6.1.1.7	ko:K01872,ko:K07050	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF692.Mbar_A2092	tRNA-synt_2c,tRNA_SAD
PYH3_k127_2885195_15	1459636.NTE_01018	1.085e-34	135.0	COG3432@1|root,arCOG01063@2157|Archaea,41T7S@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Winged helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HTH_45
PYH3_k127_2885195_2	572546.Arcpr_1848	1.053e-79	272.0	COG0410@1|root,arCOG00924@2157|Archaea,2XT1R@28890|Euryarchaeota,245VS@183980|Archaeoglobi	183980|Archaeoglobi	E	ABC transporter	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
PYH3_k127_2885195_5	374847.Kcr_0826	3.287e-70	245.0	COG0411@1|root,arCOG00926@2157|Archaea	2157|Archaea	E	COG0411 ABC-type branched-chain amino acid transport systems ATPase component	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
PYH3_k127_2885195_9	572546.Arcpr_1846	4.747e-53	199.0	COG4177@1|root,arCOG01274@2157|Archaea,2XW08@28890|Euryarchaeota,2463K@183980|Archaeoglobi	183980|Archaeoglobi	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
PYH3_k127_2885195_12	1037409.BJ6T_15790	2.549e-40	160.0	COG0559@1|root,COG0559@2|Bacteria,1N5XH@1224|Proteobacteria,2TSH5@28211|Alphaproteobacteria,3JS3Y@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
PYH3_k127_2885195_21	255470.cbdbA1365	4.691e-06	59.0	COG4249@1|root,COG4249@2|Bacteria,2GARQ@200795|Chloroflexi,34D6K@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Peptidase C13 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14
PYH3_k127_2885195_20	660470.Theba_0226	8.112e-08	64.0	COG1404@1|root,COG1520@1|root,COG4412@1|root,COG1404@2|Bacteria,COG1520@2|Bacteria,COG4412@2|Bacteria,2GED2@200918|Thermotogae	200918|Thermotogae	O	M6 family metalloprotease domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_2885195_1	192952.MM_1737	3.189e-95	324.0	COG0535@1|root,arCOG00938@2157|Archaea,2Y8D0@28890|Euryarchaeota,2N9ER@224756|Methanomicrobia	224756|Methanomicrobia	S	SMART Elongator protein 3 MiaB NifB	-	-	-	ko:K22227	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SPASM
PYH3_k127_2885195_10	694429.Pyrfu_1064	5.322e-48	189.0	COG0683@1|root,arCOG01020@2157|Archaea,2XQM1@28889|Crenarchaeota	28889|Crenarchaeota	E	Periplasmic binding protein	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
PYH3_k127_2885195_11	694429.Pyrfu_1064	2.159e-44	178.0	COG0683@1|root,arCOG01020@2157|Archaea,2XQM1@28889|Crenarchaeota	28889|Crenarchaeota	E	Periplasmic binding protein	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
PYH3_k127_290750_0	1195236.CTER_0541	9.573e-198	632.0	COG3808@1|root,COG3808@2|Bacteria,1TNZI@1239|Firmicutes,248KS@186801|Clostridia,3WHVU@541000|Ruminococcaceae	186801|Clostridia	C	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
PYH3_k127_290750_4	342949.PNA2_0786	1.601e-59	213.0	COG2236@1|root,arCOG00040@2157|Archaea,2XU0E@28890|Euryarchaeota,24312@183968|Thermococci	183968|Thermococci	F	Phosphoribosyl transferase domain	-	-	-	ko:K07101	-	-	-	-	ko00000	-	-	-	Pribosyltran
PYH3_k127_290750_2	1459636.NTE_00642	3.115e-99	330.0	COG0005@1|root,arCOG01327@2157|Archaea,41SDR@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates	mtnP	-	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
PYH3_k127_290750_3	765177.Desmu_0797	2.503e-61	230.0	COG3425@1|root,arCOG01767@2157|Archaea,2XPKK@28889|Crenarchaeota	28889|Crenarchaeota	I	Belongs to the UPF0219 family	-	-	2.3.3.10	ko:K01641	ko00072,ko00280,ko00650,ko00900,ko01100,ko01110,ko01130,map00072,map00280,map00650,map00900,map01100,map01110,map01130	M00088,M00095	R01978	RC00004,RC00503	ko00000,ko00001,ko00002,ko01000	-	-	-	ACP_syn_III,ACP_syn_III_C,HMG_CoA_synt_N,Thiolase_N
PYH3_k127_290750_5	1459636.NTE_01764	3.144e-53	192.0	COG1676@1|root,arCOG01701@2157|Archaea,41SHW@651137|Thaumarchaeota	651137|Thaumarchaeota	L	tRNA intron endonuclease, N-terminal domain	-	-	4.6.1.16	ko:K01170	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_int_endo,tRNA_int_endo_N
PYH3_k127_290750_6	436308.Nmar_1038	4.739e-18	92.0	COG1392@1|root,arCOG02640@2157|Archaea,41SGI@651137|Thaumarchaeota	651137|Thaumarchaeota	P	Protein of unknown function DUF47	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
PYH3_k127_290750_1	694429.Pyrfu_1705	2.176e-181	582.0	COG0423@1|root,arCOG00405@2157|Archaea,2XPSF@28889|Crenarchaeota	28889|Crenarchaeota	J	PFAM tRNA synthetase, class II (G, H, P and S)	glyS	GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0016874,GO:0016875,GO:0046983,GO:0140098,GO:0140101	6.1.1.14	ko:K01880	ko00970,map00970	M00359,M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	HGTP_anticodon,tRNA-synt_2b
PYH3_k127_2988959_0	768672.Desfe_0142	1.347e-36	147.0	COG0467@1|root,arCOG01171@2157|Archaea,2XPNC@28889|Crenarchaeota	28889|Crenarchaeota	T	Belongs to the UPF0273 family	-	-	-	-	-	-	-	-	-	-	-	-	ATPase
PYH3_k127_2988959_1	370438.PTH_0749	9.733e-09	64.0	COG0467@1|root,COG0467@2|Bacteria,1V05P@1239|Firmicutes,24ED2@186801|Clostridia,263QT@186807|Peptococcaceae	186801|Clostridia	T	Pfam:KaiC	-	-	-	-	-	-	-	-	-	-	-	-	ATPase
PYH3_k127_300245_5	523841.HFX_0996	2.08e-52	195.0	COG0006@1|root,arCOG01000@2157|Archaea,2XTI9@28890|Euryarchaeota,23TKY@183963|Halobacteria	183963|Halobacteria	E	Belongs to the peptidase M24B family	pepQ1	-	-	-	-	-	-	-	-	-	-	-	Creatinase_N,Peptidase_M24
PYH3_k127_300245_7	1094980.Mpsy_1303	1.563e-36	142.0	COG0526@1|root,arCOG01972@2157|Archaea,2XXRJ@28890|Euryarchaeota,2N9YG@224756|Methanomicrobia	224756|Methanomicrobia	O	Thioredoxin	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
PYH3_k127_300245_3	795359.TOPB45_0617	7.402e-78	265.0	COG0177@1|root,COG0177@2|Bacteria,2GH3R@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
PYH3_k127_300245_6	192952.MM_0209	3.471e-52	189.0	COG1793@1|root,arCOG05256@2157|Archaea,2XY7Z@28890|Euryarchaeota,2N9V7@224756|Methanomicrobia	224756|Methanomicrobia	L	DNA polymerase Ligase (LigD)	-	-	-	-	-	-	-	-	-	-	-	-	LigD_N
PYH3_k127_300245_8	933801.Ahos_1963	9.636e-10	63.0	COG1146@1|root,arCOG04548@2157|Archaea	2157|Archaea	C	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions	ferB	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_7
PYH3_k127_300245_1	247490.KSU1_C1332	6.984e-145	466.0	COG1180@1|root,COG1180@2|Bacteria,2IYWA@203682|Planctomycetes	203682|Planctomycetes	C	Radical SAM superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM
PYH3_k127_300245_2	224325.AF_2298	2.624e-79	274.0	COG1467@1|root,arCOG04110@2157|Archaea,2Y7DK@28890|Euryarchaeota,246SV@183980|Archaeoglobi	183980|Archaeoglobi	L	Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_300245_0	1041930.Mtc_1790	6.901e-148	478.0	COG0180@1|root,arCOG01887@2157|Archaea,2XSVC@28890|Euryarchaeota,2N997@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM aminoacyl-tRNA synthetase class Ib	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF692.Mbar_A1374	tRNA-synt_1b
PYH3_k127_300245_9	679926.Mpet_0592	6.594e-07	61.0	COG1941@1|root,arCOG02473@2157|Archaea,2XUXH@28890|Euryarchaeota,2N9H2@224756|Methanomicrobia	224756|Methanomicrobia	C	NADH ubiquinone oxidoreductase 20 kDa subunit	frhG-1	-	1.12.98.1	ko:K00443	ko00680,ko01100,ko01120,map00680,map01100,map01120	-	R03025	RC02628	ko00000,ko00001,ko01000	-	-	-	Fer4,Oxidored_q6
PYH3_k127_300245_4	1220534.B655_2215	8.879e-53	200.0	COG1035@1|root,arCOG02651@2157|Archaea,2XUH6@28890|Euryarchaeota,23NWU@183925|Methanobacteria	183925|Methanobacteria	C	PFAM Coenzyme F420 hydrogenase dehydrogenase beta subunit	frhB1	-	1.12.98.1	ko:K00441	ko00680,ko01100,ko01120,map00680,map01100,map01120	-	R03025	RC02628	ko00000,ko00001,ko01000	-	-	-	FrhB_FdhB_C,FrhB_FdhB_N
PYH3_k127_300245_10	338963.Pcar_0413	9.893e-06	50.0	COG1597@1|root,COG1597@2|Bacteria,1MY37@1224|Proteobacteria,42RSB@68525|delta/epsilon subdivisions,2WNIX@28221|Deltaproteobacteria,43SHX@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	Diacylglycerol kinase catalytic domain (presumed)	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
PYH3_k127_3025404_0	525904.Tter_0750	5.76e-90	306.0	COG0123@1|root,COG0123@2|Bacteria,2NP8V@2323|unclassified Bacteria	2|Bacteria	BQ	Histone deacetylase domain	-	-	-	ko:K04768	-	-	-	-	ko00000	-	-	-	Hist_deacetyl
PYH3_k127_3025404_1	195522.BD01_1077	3.525e-15	82.0	COG0071@1|root,arCOG01832@2157|Archaea,2XYW4@28890|Euryarchaeota,243RJ@183968|Thermococci	183968|Thermococci	O	Belongs to the small heat shock protein (HSP20) family	hsp20	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
PYH3_k127_3025404_2	797302.Halru_2435	1.023e-14	84.0	COG1938@1|root,arCOG00347@2157|Archaea,2XT93@28890|Euryarchaeota,23SEU@183963|Halobacteria	183963|Halobacteria	S	COG1938 Archaeal enzymes of ATP-grasp superfamily	-	-	-	ko:K06869	-	-	-	-	ko00000	-	-	-	PAC2
PYH3_k127_3123527_1	399550.Smar_1224	1.415e-74	263.0	COG0470@1|root,arCOG00470@2157|Archaea,2XPN9@28889|Crenarchaeota	28889|Crenarchaeota	L	Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA	rfcL	-	-	ko:K04800	ko03030,map03030	-	-	-	ko00000,ko00001,ko03032	-	-	-	AAA,RFC1,Rad17
PYH3_k127_3123527_4	1173024.KI912153_gene51	0.0001915	51.0	COG2405@1|root,COG2405@2|Bacteria,1G5DX@1117|Cyanobacteria	1117|Cyanobacteria	S	nucleic acid-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3368
PYH3_k127_3123527_3	1114856.C496_20020	9.677e-05	52.0	arCOG04629@1|root,arCOG04629@2157|Archaea,2XYVJ@28890|Euryarchaeota,23WZG@183963|Halobacteria	183963|Halobacteria	S	Uncharacterised protein family (UPF0175)	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1,UPF0175
PYH3_k127_3123527_2	436308.Nmar_1783	4.349e-40	158.0	COG2112@1|root,arCOG01182@2157|Archaea,41SJV@651137|Thaumarchaeota	651137|Thaumarchaeota	T	Ser thr protein kinase	-	-	-	ko:K07176	-	-	-	-	ko00000	-	-	-	RIO1
PYH3_k127_3123527_0	868131.MSWAN_0911	4.871e-80	284.0	COG1746@1|root,arCOG04249@2157|Archaea,2XT5J@28890|Euryarchaeota,23NVX@183925|Methanobacteria	183925|Methanobacteria	J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate	cca	-	2.7.7.72	ko:K07558	-	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko01000,ko03016	-	-	-	NTP_transf_2,tRNA_NucTransf2
PYH3_k127_3222847_6	56110.Oscil6304_5587	1.195e-18	94.0	COG2848@1|root,COG2848@2|Bacteria,1G3IK@1117|Cyanobacteria	1117|Cyanobacteria	S	Uncharacterised ACR (DUF711)	-	-	-	ko:K09157	-	-	-	-	ko00000	-	-	-	DUF711
PYH3_k127_3222847_8	1131266.ARWQ01000001_gene1084	2.137e-15	81.0	arCOG05529@1|root,arCOG05529@2157|Archaea,41SSJ@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	dsDNA_bind
PYH3_k127_3222847_2	415426.Hbut_1592	3.706e-60	215.0	COG1756@1|root,arCOG04122@2157|Archaea,2XQJ6@28889|Crenarchaeota	28889|Crenarchaeota	J	Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA	nep1	GO:0000154,GO:0000462,GO:0001510,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0019843,GO:0022613,GO:0030490,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070037,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140098,GO:0140102,GO:1901360,GO:1901363	2.1.1.260	ko:K14568	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko03009	-	-	-	EMG1
PYH3_k127_3222847_4	342949.PNA2_0186	4.881e-25	108.0	COG2023@1|root,arCOG04345@2157|Archaea,2XYX0@28890|Euryarchaeota,244AW@183968|Thermococci	183968|Thermococci	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp4	GO:0000966,GO:0001682,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0032991,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1902555,GO:1905348,GO:1990904	3.1.26.5	ko:K03540	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Rpr2
PYH3_k127_3222847_10	456442.Mboo_1888	2.064e-05	51.0	COG1534@1|root,arCOG01346@2157|Archaea	2157|Archaea	J	RNA-binding protein containing KH domain possibly ribosomal protein	-	-	-	ko:K07574	-	-	-	-	ko00000,ko03009	-	-	-	CRS1_YhbY
PYH3_k127_3222847_0	247490.KSU1_C0752	2.119e-111	377.0	COG1488@1|root,COG1488@2|Bacteria,2IXDA@203682|Planctomycetes	203682|Planctomycetes	F	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP	-	-	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	-	NAPRTase
PYH3_k127_3222847_3	1184251.TCELL_0376	6.33e-37	144.0	COG2238@1|root,arCOG01344@2157|Archaea,2XQKX@28889|Crenarchaeota	28889|Crenarchaeota	J	May be involved in maturation of the 30S ribosomal subunit	rps19e	-	-	ko:K02966	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19e
PYH3_k127_3222847_5	930945.SiRe_1648	6.695e-25	107.0	COG2118@1|root,arCOG04179@2157|Archaea,2XQYZ@28889|Crenarchaeota	28889|Crenarchaeota	L	Belongs to the PDCD5 family	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K06875	-	-	-	-	ko00000	-	-	-	dsDNA_bind
PYH3_k127_3222847_9	342949.PNA2_1157	3.825e-11	64.0	COG2167@1|root,arCOG04177@2157|Archaea,2XZSY@28890|Euryarchaeota,244NC@183968|Thermococci	183968|Thermococci	J	Belongs to the eukaryotic ribosomal protein eL39 family	rpl39e	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02924	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L39
PYH3_k127_3222847_7	1220534.B655_1851	7.392e-18	88.0	COG2097@1|root,arCOG04473@2157|Archaea,2XYWX@28890|Euryarchaeota,23P8C@183925|Methanobacteria	183925|Methanobacteria	J	Belongs to the ribosomal protein L31e family	rpl31e	-	-	ko:K02910	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31e
PYH3_k127_3222847_1	224325.AF_1199	3.246e-83	287.0	COG1788@1|root,arCOG01987@2157|Archaea,2XVRA@28890|Euryarchaeota,246WP@183980|Archaeoglobi	183980|Archaeoglobi	I	Coenzyme A transferase	-	-	2.8.3.12	ko:K01039	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
PYH3_k127_3475268_0	1382306.JNIM01000001_gene2320	7.668e-142	469.0	COG1123@1|root,COG4172@2|Bacteria,2GBJ7@200795|Chloroflexi	2|Bacteria	P	COGs COG1123 ATPase components of various ABC-type transport systems contain duplicated ATPase	-	-	3.6.3.24	ko:K02031,ko:K02032,ko:K10824,ko:K15587,ko:K16784,ko:K16786,ko:K16787	ko02010,ko02024,map02010,map02024	M00239,M00440,M00581,M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.25.1,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35,3.A.1.5	-	-	ABC_tran
PYH3_k127_3475268_1	1382306.JNIM01000001_gene2321	1.523e-36	149.0	COG0619@1|root,COG0619@2|Bacteria	2|Bacteria	P	transmembrane transporter activity	-	-	-	ko:K16785,ko:K16786,ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran,CbiQ
PYH3_k127_3475268_2	1265505.ATUG01000002_gene2506	1.832e-15	81.0	COG5598@1|root,COG5598@2|Bacteria,1N18H@1224|Proteobacteria,43BDY@68525|delta/epsilon subdivisions,2X6SF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Trimethylamine methyltransferase (MTTB)	-	-	-	-	-	-	-	-	-	-	-	-	MTTB
PYH3_k127_3522376_4	1321778.HMPREF1982_02017	1.274e-53	196.0	COG0631@1|root,COG0631@2|Bacteria,1V6K5@1239|Firmicutes,24JD4@186801|Clostridia,26800@186813|unclassified Clostridiales	186801|Clostridia	T	Serine/threonine phosphatases, family 2C, catalytic domain	stp	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C,PP2C_2
PYH3_k127_3522376_6	134676.ACPL_6512	2.95e-28	128.0	COG0515@1|root,COG0515@2|Bacteria,2GMPZ@201174|Actinobacteria,4DAJ5@85008|Micromonosporales	201174|Actinobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
PYH3_k127_3522376_3	1123371.ATXH01000003_gene1893	1.495e-61	219.0	COG1926@1|root,COG1926@2|Bacteria	2|Bacteria	Q	phosphoribosyltransferase	-	-	-	ko:K07100	-	-	-	-	ko00000	-	-	-	Pribosyltran
PYH3_k127_3522376_1	1459636.NTE_02288	1.956e-90	312.0	COG4046@1|root,arCOG04181@2157|Archaea,41S8T@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Protein of unknown function (DUF1512)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1512
PYH3_k127_3522376_2	391623.TERMP_00696	2.525e-75	262.0	COG0024@1|root,arCOG01001@2157|Archaea,2XT8G@28890|Euryarchaeota,242WX@183968|Thermococci	183968|Thermococci	E	Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val)	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
PYH3_k127_3522376_0	1459636.NTE_01984	3.508e-152	490.0	COG0012@1|root,arCOG00357@2157|Archaea,41S8X@651137|Thaumarchaeota	651137|Thaumarchaeota	J	GTPase of unknown function C-terminal	-	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,MMR_HSR1_C,TGS
PYH3_k127_3522376_5	263820.PTO1105	5.278e-36	143.0	COG3620@1|root,arCOG00608@2157|Archaea,2XTDG@28890|Euryarchaeota,241RM@183967|Thermoplasmata	183967|Thermoplasmata	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,HTH_3
PYH3_k127_3528320_10	342949.PNA2_1862	6.321e-35	137.0	COG0251@1|root,arCOG01630@2157|Archaea,2XXUZ@28890|Euryarchaeota,244C0@183968|Thermococci	183968|Thermococci	J	Endoribonuclease L-PSP	-	GO:0003674,GO:0003824,GO:0016787,GO:0019239	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
PYH3_k127_3528320_5	593750.Metfor_2560	9.368e-93	313.0	COG0648@1|root,arCOG01894@2157|Archaea,2XV5I@28890|Euryarchaeota	28890|Euryarchaeota	L	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin	nfo	-	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
PYH3_k127_3528320_9	1047013.AQSP01000115_gene356	1.848e-42	179.0	COG0436@1|root,COG0436@2|Bacteria,2NP1C@2323|unclassified Bacteria	2|Bacteria	E	Aminotransferase	aspB	GO:0003674,GO:0003824,GO:0008483,GO:0016740,GO:0016769,GO:0047297	2.6.1.1,2.6.1.14	ko:K00812,ko:K22457	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R01346,R02433,R02619,R05052	RC00006,RC00025	ko00000,ko00001,ko01000,ko01007	-	-	iHN637.CLJU_RS06550	Aminotran_1_2
PYH3_k127_3528320_1	247490.KSU1_D0718	3.467e-203	662.0	COG1866@1|root,COG1866@2|Bacteria	2|Bacteria	H	phosphoenolpyruvate carboxykinase (ATP) activity	pckA	-	4.1.1.49	ko:K01610	ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00170	R00341	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_ATP
PYH3_k127_3528320_12	1459636.NTE_02170	4.086e-08	60.0	COG5431@1|root,arCOG01120@2157|Archaea,41SW3@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_3528320_7	1094980.Mpsy_0913	2.183e-51	192.0	COG1407@1|root,arCOG01150@2157|Archaea,2XU3W@28890|Euryarchaeota,2N9DU@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM metallophosphoesterase	-	-	-	ko:K06953	-	-	-	-	ko00000	-	-	-	Metallophos,Metallophos_2
PYH3_k127_3528320_11	1459636.NTE_01997	1.287e-18	89.0	COG1828@1|root,arCOG04462@2157|Archaea,41STY@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purS	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	PurS
PYH3_k127_3528320_6	192952.MM_2807	5.366e-79	269.0	COG0047@1|root,arCOG00102@2157|Archaea,2XTPA@28890|Euryarchaeota,2N9HC@224756|Methanomicrobia	224756|Methanomicrobia	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purQ	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A2755	GATase_5
PYH3_k127_3528320_0	1449126.JQKL01000015_gene2926	1.333e-209	675.0	COG0046@1|root,COG0046@2|Bacteria,1TPAS@1239|Firmicutes,247W2@186801|Clostridia,267K1@186813|unclassified Clostridiales	186801|Clostridia	F	AIR synthase related protein, C-terminal domain	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C,GATase_5
PYH3_k127_3528320_3	868131.MSWAN_0509	1.05e-130	432.0	COG0034@1|root,arCOG00093@2157|Archaea,2XSWJ@28890|Euryarchaeota,23NJB@183925|Methanobacteria	183925|Methanobacteria	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
PYH3_k127_3528320_8	269797.Mbar_A3125	1.518e-46	172.0	COG0041@1|root,arCOG02464@2157|Archaea,2XU0P@28890|Euryarchaeota,2N9SG@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
PYH3_k127_3528320_4	1459636.NTE_02880	5.292e-95	323.0	COG0150@1|root,arCOG00639@2157|Archaea,41SEE@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Phosphoribosylformylglycinamidine cyclo-ligase	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
PYH3_k127_3528320_2	555079.Toce_2249	3.303e-181	578.0	COG2509@1|root,COG2509@2|Bacteria,1TP9I@1239|Firmicutes,247QM@186801|Clostridia,42FH5@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM FAD dependent oxidoreductase	-	-	-	ko:K07137	-	-	-	-	ko00000	-	-	-	FAD_binding_2,HI0933_like,Pyr_redox_2,Thi4
PYH3_k127_3528320_13	665571.STHERM_c15490	3.469e-07	58.0	2E8ZQ@1|root,33397@2|Bacteria,2J942@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_3558851_7	926569.ANT_00120	1.321e-29	125.0	COG1668@1|root,COG1668@2|Bacteria,2G76A@200795|Chloroflexi	200795|Chloroflexi	CP	ABC-2 family transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_2
PYH3_k127_3558851_3	1144275.COCOR_06077	8.21e-70	247.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,42S2J@68525|delta/epsilon subdivisions,2X7BN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	ABC transporter, ATP-binding protein	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
PYH3_k127_3558851_0	1443122.Z958_00375	1.442e-110	363.0	COG1951@1|root,COG1951@2|Bacteria,1TPXQ@1239|Firmicutes,248T7@186801|Clostridia,36DM3@31979|Clostridiaceae	186801|Clostridia	C	Fe-S type, tartrate fumarate subfamily, alpha	-	-	4.2.1.2	ko:K01677	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase
PYH3_k127_3558851_4	1118054.CAGW01000056_gene2099	1.596e-67	237.0	COG1838@1|root,COG1838@2|Bacteria,1V1CP@1239|Firmicutes,4IQVA@91061|Bacilli	91061|Bacilli	C	COG1838 Tartrate dehydratase beta subunit Fumarate hydratase class I, C-terminal domain	-	-	4.2.1.2	ko:K01678	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase_C
PYH3_k127_3558851_2	1347392.CCEZ01000043_gene137	1.624e-77	270.0	COG0031@1|root,COG0031@2|Bacteria,1TP30@1239|Firmicutes,2497G@186801|Clostridia,36EJD@31979|Clostridiaceae	186801|Clostridia	E	Belongs to the cysteine synthase cystathionine beta- synthase family	cysK	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
PYH3_k127_3558851_6	1121422.AUMW01000008_gene502	2.639e-33	133.0	COG2050@1|root,COG2050@2|Bacteria,1VFHF@1239|Firmicutes,24QNY@186801|Clostridia,262QC@186807|Peptococcaceae	186801|Clostridia	Q	PFAM thioesterase superfamily	-	-	-	ko:K02614	ko00360,map00360	-	R09840	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	4HBT
PYH3_k127_3558851_5	797209.ZOD2009_07809	2.433e-48	179.0	COG2041@1|root,arCOG00264@2157|Archaea,2XU2G@28890|Euryarchaeota,23SCW@183963|Halobacteria	183963|Halobacteria	S	COG2041 Sulfite oxidase and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_molyb
PYH3_k127_3558851_8	398511.BpOF4_07260	5.231e-13	78.0	COG0454@1|root,COG0456@2|Bacteria,1U521@1239|Firmicutes,4HBEJ@91061|Bacilli,1ZCHR@1386|Bacillus	91061|Bacilli	K	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases	ykwB	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
PYH3_k127_3558851_1	1459636.NTE_01332	9.164e-100	338.0	COG0477@1|root,arCOG00130@2157|Archaea	2157|Archaea	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
PYH3_k127_3764587_10	645991.Sgly_1017	3.278e-74	258.0	COG1924@1|root,COG1924@2|Bacteria,1TQSD@1239|Firmicutes,2481W@186801|Clostridia,261IU@186807|Peptococcaceae	186801|Clostridia	I	PFAM BadF BadG BcrA BcrD ATPase family	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG
PYH3_k127_3764587_19	269797.Mbar_A0578	1.321e-28	131.0	COG0348@1|root,arCOG02772@2157|Archaea	2157|Archaea	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_5
PYH3_k127_3764587_21	1183377.Py04_0340	1.297e-24	110.0	COG1852@1|root,arCOG02078@2157|Archaea,2XWB4@28890|Euryarchaeota,243SX@183968|Thermococci	183968|Thermococci	S	Protein of unknown function DUF116	-	-	-	ko:K09729	-	-	-	-	ko00000	-	-	-	DUF116
PYH3_k127_3764587_2	986075.CathTA2_1446	4.634e-122	403.0	COG1804@1|root,COG1804@2|Bacteria,1TP54@1239|Firmicutes,4HC4S@91061|Bacilli	91061|Bacilli	C	carnitine dehydratase	amacr	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
PYH3_k127_3764587_3	387631.Asulf_00867	1.175e-111	377.0	COG1042@1|root,arCOG01338@2157|Archaea,arCOG01340@2157|Archaea,2XT9G@28890|Euryarchaeota,246RE@183980|Archaeoglobi	183980|Archaeoglobi	C	acetyl coenzyme A synthetase	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
PYH3_k127_3764587_6	1343739.PAP_10190	2.5e-94	317.0	COG4608@1|root,arCOG00184@2157|Archaea,2Y5BH@28890|Euryarchaeota,243F9@183968|Thermococci	183968|Thermococci	E	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
PYH3_k127_3764587_9	765177.Desmu_0799	2.225e-80	276.0	COG0444@1|root,arCOG00181@2157|Archaea,2XPR3@28889|Crenarchaeota	28889|Crenarchaeota	E	TIGRFAM oligopeptide dipeptide ABC transporter, ATPase subunit	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
PYH3_k127_3764587_4	580340.Tlie_0352	2.514e-99	349.0	COG0747@1|root,COG0747@2|Bacteria,3TAM5@508458|Synergistetes	508458|Synergistetes	E	PFAM Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
PYH3_k127_3764587_8	572547.Amico_1778	1.344e-85	294.0	COG0601@1|root,COG0601@2|Bacteria,3TAG1@508458|Synergistetes	508458|Synergistetes	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
PYH3_k127_3764587_13	272844.PAB1195	6.511e-73	267.0	COG1173@1|root,arCOG00749@2157|Archaea,2Y86R@28890|Euryarchaeota,243AT@183968|Thermococci	183968|Thermococci	P	N-terminal TM domain of oligopeptide transport permease C	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
PYH3_k127_3764587_12	592015.HMPREF1705_00648	1.758e-73	256.0	COG0095@1|root,COG0095@2|Bacteria,3TBDG@508458|Synergistetes	508458|Synergistetes	H	PFAM Biotin lipoate A B protein ligase family	-	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
PYH3_k127_3764587_26	1184251.TCELL_1336	1.278e-10	65.0	COG0095@1|root,arCOG03837@2157|Archaea,2XRCT@28889|Crenarchaeota	28889|Crenarchaeota	H	Bacterial lipoate protein ligase C-terminus	-	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	Lip_prot_lig_C
PYH3_k127_3764587_24	1196031.ALEG01000008_gene5098	1.574e-16	87.0	COG0526@1|root,COG0526@2|Bacteria,1VAPY@1239|Firmicutes,4HJN1@91061|Bacilli,1ZFAP@1386|Bacillus	91061|Bacilli	CO	COG0526 Thiol-disulfide isomerase and thioredoxins	stoA	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
PYH3_k127_3764587_22	742735.HMPREF9467_00193	8.591e-24	111.0	COG1028@1|root,COG1028@2|Bacteria,1TPIK@1239|Firmicutes,25073@186801|Clostridia	186801|Clostridia	IQ	Psort location Cytoplasmic, score	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
PYH3_k127_3764587_17	1348908.KI518587_gene2918	6.112e-57	207.0	COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,4HAA6@91061|Bacilli,1ZCDY@1386|Bacillus	91061|Bacilli	IQ	reductase	fabG	GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	iYO844.BSU15910	adh_short_C2
PYH3_k127_3764587_23	1122223.KB890687_gene2892	1.688e-19	93.0	COG2905@1|root,COG2905@2|Bacteria,1WJV4@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	T	signal-transduction protein containing cAMP-binding and CBS domains	-	-	-	-	-	-	-	-	-	-	-	-	CBS
PYH3_k127_3764587_5	456442.Mboo_1369	5.961e-95	327.0	COG1456@1|root,arCOG01979@2157|Archaea,2XUSG@28890|Euryarchaeota,2N9BD@224756|Methanomicrobia	224756|Methanomicrobia	C	Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing	cdhE	-	2.1.1.245	ko:K00197	ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200	M00357,M00377,M00422	R09096,R10219,R10243	RC00004,RC00113,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhD,FeS
PYH3_k127_3764587_16	693661.Arcve_1125	4.026e-57	211.0	COG2069@1|root,arCOG01980@2157|Archaea,2XTXS@28890|Euryarchaeota,245TW@183980|Archaeoglobi	183980|Archaeoglobi	C	Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). Probably maintains the overall quaternary structure of the ACDS complex	cdhD	-	2.1.1.245	ko:K00194	ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200	M00357,M00377,M00422	R09096,R10219,R10243	RC00004,RC00113,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhD
PYH3_k127_3764587_27	985053.VMUT_0928	1.182e-06	55.0	COG4755@1|root,arCOG04123@2157|Archaea,2XQIF@28889|Crenarchaeota	28889|Crenarchaeota	S	protein conserved in archaea (DUF2153)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2153
PYH3_k127_3764587_15	1459636.NTE_00618	6.47e-64	224.0	COG2101@1|root,arCOG01764@2157|Archaea,41SZD@651137|Thaumarchaeota	651137|Thaumarchaeota	K	General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation	-	-	-	ko:K03120	ko03022,ko05016,ko05165,ko05166,ko05168,ko05169,ko05203,map03022,map05016,map05165,map05166,map05168,map05169,map05203	-	-	-	ko00000,ko00001,ko03000,ko03021	-	-	-	TBP
PYH3_k127_3764587_25	1070774.J07HN4v3_00095	2.137e-11	75.0	arCOG07655@1|root,arCOG07655@2157|Archaea,2Y71F@28890|Euryarchaeota,23UID@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_3764587_28	1094508.Tsac_0839	0.0002488	47.0	COG3703@1|root,COG3703@2|Bacteria	2|Bacteria	P	gamma-glutamylcyclotransferase activity	ykqA	-	-	-	-	-	-	-	-	-	-	-	AIG2_2,GGACT
PYH3_k127_3764587_0	1459636.NTE_02878	1.641e-180	580.0	COG1384@1|root,arCOG00485@2157|Archaea,41SB4@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the class-I aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04566	ko00970,map00970	M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1f
PYH3_k127_3764587_7	453591.Igni_0637	2.734e-88	306.0	COG0519@1|root,arCOG00085@2157|Archaea,2XPVC@28889|Crenarchaeota	28889|Crenarchaeota	F	GMP synthase, glutamine-hydrolyzing	guaA	GO:0000162,GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005950,GO:0006082,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0032991,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042401,GO:0042430,GO:0042435,GO:0042451,GO:0042455,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046129,GO:0046219,GO:0046390,GO:0046394,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901657,GO:1901659,GO:1902494	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
PYH3_k127_3764587_1	391623.TERMP_00652	1.281e-163	538.0	COG0550@1|root,arCOG01305@1|root,arCOG01305@2157|Archaea,arCOG01527@2157|Archaea,2XU6T@28890|Euryarchaeota,242TJ@183968|Thermococci	183968|Thermococci	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Intein_splicing,LAGLIDADG_3,Topoisom_bac,Toprim,zf-C4_Topoisom
PYH3_k127_3764587_11	448385.sce8608	7.843e-74	264.0	COG1215@1|root,COG1215@2|Bacteria,1MX08@1224|Proteobacteria,42MS6@68525|delta/epsilon subdivisions,2WIYE@28221|Deltaproteobacteria,2YUMA@29|Myxococcales	28221|Deltaproteobacteria	M	Glycosyl transferase family 21	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3
PYH3_k127_3764587_18	1192034.CAP_5784	6.389e-38	152.0	COG1216@1|root,COG1216@2|Bacteria,1QX3U@1224|Proteobacteria,42RP8@68525|delta/epsilon subdivisions,2WNF5@28221|Deltaproteobacteria,2Z30X@29|Myxococcales	28221|Deltaproteobacteria	S	Glycosyltransferase like family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
PYH3_k127_3764587_14	930945.SiRe_1558	1.109e-67	240.0	COG0010@1|root,arCOG01700@2157|Archaea,2XQGD@28889|Crenarchaeota	28889|Crenarchaeota	E	Belongs to the arginase family	speB	-	3.5.3.11	ko:K01480	ko00330,ko01100,map00330,map01100	M00133	R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
PYH3_k127_3764587_20	1125863.JAFN01000001_gene1966	1.009e-27	130.0	COG0823@1|root,COG0823@2|Bacteria,1QW3I@1224|Proteobacteria	1224|Proteobacteria	U	Beta Propeller	-	-	-	-	-	-	-	-	-	-	-	-	PD40
PYH3_k127_3852702_3	1459636.NTE_01660	1.479e-05	50.0	arCOG07192@1|root,arCOG07192@2157|Archaea,41SVA@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_3852702_0	330779.Saci_0773	2.221e-280	878.0	COG0464@1|root,arCOG01308@2157|Archaea,2XPPI@28889|Crenarchaeota	28889|Crenarchaeota	O	Cell division protein 48 (CDC48), domain 2	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N,Vps4_C
PYH3_k127_3852702_2	1056495.Calag_1447	1.399e-14	79.0	COG2092@1|root,arCOG01988@2157|Archaea,2XR49@28889|Crenarchaeota	28889|Crenarchaeota	J	Promotes the exchange of GDP for GTP in EF-1-alpha GDP, thus allowing the regeneration of EF-1-alpha GTP that could then be used to form the ternary complex EF-1-alpha GTP AAtRNA	ef1b	-	-	ko:K03232	-	-	-	-	ko00000,ko03012	-	-	-	EF1_GNE
PYH3_k127_3852702_1	368408.Tpen_0662	8.566e-17	81.0	COG2888@1|root,arCOG01989@2157|Archaea,2XRFA@28889|Crenarchaeota	28889|Crenarchaeota	J	Domain of unknown function (DUF1610)	-	-	-	ko:K07580	-	-	-	-	ko00000	-	-	-	DUF1610
PYH3_k127_3857360_13	1220534.B655_2423	3.488e-12	68.0	COG0053@1|root,arCOG01475@2157|Archaea,2Y8CZ@28890|Euryarchaeota	28890|Euryarchaeota	P	TIGRFAM cation diffusion facilitator family transporter	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,Nitro_FeMo-Co,ZT_dimer
PYH3_k127_3857360_12	1390370.O203_14825	5.771e-13	81.0	COG0477@1|root,COG2814@2|Bacteria,1MVQQ@1224|Proteobacteria,1RNR4@1236|Gammaproteobacteria,1YDPS@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	EGP	Uncharacterised MFS-type transporter YbfB	benK	-	-	ko:K05548	-	-	-	-	ko00000,ko02000	2.A.1.15	-	-	MFS_1,MFS_4,Sugar_tr
PYH3_k127_3857360_10	640511.BC1002_6762	9.194e-16	83.0	COG0071@1|root,COG0071@2|Bacteria,1RH6E@1224|Proteobacteria,2VRIE@28216|Betaproteobacteria,1K4NJ@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
PYH3_k127_3857360_8	926560.KE387027_gene654	8.11e-80	289.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1WKH0@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	EU	PFAM Prolyl oligopeptidase family	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
PYH3_k127_3857360_3	1459636.NTE_00936	5.994e-166	533.0	COG0151@1|root,arCOG04415@2157|Archaea	2157|Archaea	F	Belongs to the GARS family	purD1	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C
PYH3_k127_3857360_1	1499967.BAYZ01000069_gene1853	0.0	1055.0	COG0474@1|root,COG0474@2|Bacteria,2NNSC@2323|unclassified Bacteria	2|Bacteria	P	Cation transporter/ATPase, N-terminus	pacL	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
PYH3_k127_3857360_7	690850.Desaf_1848	7.321e-85	294.0	COG0517@1|root,COG1994@1|root,COG0517@2|Bacteria,COG1994@2|Bacteria,1MY9R@1224|Proteobacteria,42R1V@68525|delta/epsilon subdivisions,2WN7S@28221|Deltaproteobacteria,2MEHG@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Belongs to the peptidase M50B family	-	-	-	-	-	-	-	-	-	-	-	-	CBS,Peptidase_M50,Peptidase_M50B
PYH3_k127_3857360_11	869210.Marky_1036	3.062e-13	70.0	COG3350@1|root,COG3350@2|Bacteria,1WN5Y@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	YHS domain	-	-	-	-	-	-	-	-	-	-	-	-	YHS
PYH3_k127_3857360_5	247490.KSU1_C0456	4.216e-124	410.0	COG3635@1|root,COG3635@2|Bacteria,2IY5S@203682|Planctomycetes	203682|Planctomycetes	G	phosphoglycerate mutase	-	-	5.4.2.12	ko:K15635	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,PhosphMutase
PYH3_k127_3857360_4	1459636.NTE_01678	2.313e-126	416.0	COG0126@1|root,arCOG00496@2157|Archaea,41SMB@651137|Thaumarchaeota	651137|Thaumarchaeota	G	Phosphoglycerate kinase	pgk	-	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
PYH3_k127_3857360_14	1227499.C493_17556	1.31e-05	56.0	COG0697@1|root,arCOG00272@2157|Archaea,2XUQJ@28890|Euryarchaeota,23UUC@183963|Halobacteria	183963|Halobacteria	G	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
PYH3_k127_3857360_9	742766.HMPREF9455_03265	1.254e-54	203.0	COG0152@1|root,COG0152@2|Bacteria,4NF1Z@976|Bacteroidetes,2FPKZ@200643|Bacteroidia,22WD6@171551|Porphyromonadaceae	976|Bacteroidetes	F	Catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis	purC	-	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
PYH3_k127_3857360_6	391623.TERMP_01070	3.531e-112	372.0	COG0009@1|root,arCOG01952@2157|Archaea,2XVGC@28890|Euryarchaeota,243AA@183968|Thermococci	183968|Thermococci	J	required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine	-	GO:0002949,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	SUA5,Sua5_yciO_yrdC
PYH3_k127_3857360_2	521011.Mpal_0225	1.987e-303	953.0	COG0474@1|root,arCOG01578@2157|Archaea,2XW9Y@28890|Euryarchaeota,2N9BB@224756|Methanomicrobia	224756|Methanomicrobia	P	Cation transporter/ATPase, N-terminus	-	-	3.6.3.2	ko:K01531	-	-	-	-	ko00000,ko01000	3.A.3.4	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
PYH3_k127_3857360_0	572546.Arcpr_0660	0.0	1471.0	COG0458@1|root,arCOG01594@2157|Archaea,2XTVE@28890|Euryarchaeota,245PG@183980|Archaeoglobi	183980|Archaeoglobi	F	Belongs to the CarB family	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
PYH3_k127_3937733_0	573064.Mefer_0922	4.673e-73	265.0	COG1328@1|root,arCOG03714@1|root,arCOG03714@2157|Archaea,arCOG04889@2157|Archaea,2XT2S@28890|Euryarchaeota,23Q3Z@183939|Methanococci	183939|Methanococci	F	TIGRFAM anaerobic ribonucleoside-triphosphate reductase	-	-	1.1.98.6	ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R11633,R11634,R11635,R11636	RC00613	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-cone,Intein_splicing,LAGLIDADG_3,NRDD
PYH3_k127_3937733_1	452637.Oter_2385	1.503e-25	112.0	COG1694@1|root,COG1694@2|Bacteria,46W6C@74201|Verrucomicrobia,3K875@414999|Opitutae	414999|Opitutae	S	MazG-like family	-	-	-	-	-	-	-	-	-	-	-	-	MazG-like
PYH3_k127_4037253_2	290398.Csal_2166	1.269e-37	148.0	COG0077@1|root,COG1605@1|root,COG0077@2|Bacteria,COG1605@2|Bacteria,1MU60@1224|Proteobacteria,1RNRD@1236|Gammaproteobacteria,1XISZ@135619|Oceanospirillales	135619|Oceanospirillales	E	Prephenate dehydratase	pheA	-	4.2.1.51,5.4.99.5	ko:K14170	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R00691,R01373,R01715	RC00360,RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,CM_2,PDT
PYH3_k127_4037253_0	1220534.B655_1543	1.134e-113	381.0	COG0141@1|root,arCOG04352@2157|Archaea,2XT6M@28890|Euryarchaeota,23NVT@183925|Methanobacteria	183925|Methanobacteria	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	-	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
PYH3_k127_4037253_1	1304880.JAGB01000001_gene290	1.63e-63	232.0	COG0079@1|root,COG0079@2|Bacteria,1TPUV@1239|Firmicutes,24837@186801|Clostridia	186801|Clostridia	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	GO:0003674,GO:0003824,GO:0008110,GO:0008483,GO:0016740,GO:0016769	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
PYH3_k127_4037253_3	1071085.KK033114_gene302	3.546e-25	119.0	COG0546@1|root,arCOG04692@2157|Archaea,2XUI7@28890|Euryarchaeota,23SAI@183963|Halobacteria	183963|Halobacteria	S	hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2,Hydrolase
PYH3_k127_4053370_11	415426.Hbut_0543	1.739e-42	159.0	COG1358@1|root,arCOG01751@2157|Archaea,2XQH4@28889|Crenarchaeota	28889|Crenarchaeota	J	Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H ACA, box C D and box C' D' sRNAs	rpl7ae	GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02936	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03009,ko03011	-	-	-	Ribosomal_L7Ae
PYH3_k127_4053370_14	591019.Shell_1641	3.709e-27	111.0	COG2053@1|root,arCOG04314@2157|Archaea,2XQTB@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eS28 family	rps28e	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990904	-	ko:K02979	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S28e
PYH3_k127_4053370_18	273063.STK_02804	6.946e-18	84.0	COG2075@1|root,arCOG01950@2157|Archaea,2XR6Q@28889|Crenarchaeota	28889|Crenarchaeota	J	binds to the 23S rRNA	rpl24e	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1902626,GO:1990904	-	ko:K02896	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L24e
PYH3_k127_4053370_8	589924.Ferp_0618	4.259e-45	169.0	COG0105@1|root,arCOG04313@2157|Archaea,2XWSK@28890|Euryarchaeota,2465T@183980|Archaeoglobi	183980|Archaeoglobi	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	-	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
PYH3_k127_4053370_0	694429.Pyrfu_1882	1.771e-189	608.0	COG0532@1|root,arCOG01560@2157|Archaea,2XPQ5@28889|Crenarchaeota	28889|Crenarchaeota	J	Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2	infB	-	-	ko:K03243	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D4,IF-2
PYH3_k127_4053370_15	1459636.NTE_03034	1.001e-26	114.0	COG2125@1|root,arCOG01946@2157|Archaea,41SPC@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the eukaryotic ribosomal protein eS6 family	rps6e	-	-	ko:K02991	ko01521,ko03010,ko04066,ko04150,ko04151,ko04371,ko04714,ko04910,ko05205,map01521,map03010,map04066,map04150,map04151,map04371,map04714,map04910,map05205	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S6e
PYH3_k127_4053370_21	1184251.TCELL_0551	1.334e-08	62.0	COG2004@1|root,arCOG04182@2157|Archaea,2XQW2@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eS24 family	rps24e	-	-	ko:K02974	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S24e
PYH3_k127_4053370_19	272557.APE_1132a	7.992e-17	81.0	COG1998@1|root,arCOG04183@2157|Archaea,2XR6N@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eS31 family	rps27ae	-	-	ko:K02977	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko04147	-	-	-	Ribosomal_S27
PYH3_k127_4053370_20	192952.MM_0598	8.453e-16	84.0	COG1909@1|root,arCOG04076@2157|Archaea,2XXSG@28890|Euryarchaeota,2N9R8@224756|Methanomicrobia	224756|Methanomicrobia	S	Belongs to the UPF0218 family	-	-	-	ko:K09735	-	-	-	-	ko00000	-	-	-	DUF359
PYH3_k127_4053370_17	1183377.Py04_0406	4.866e-20	90.0	COG2093@1|root,arCOG04077@2157|Archaea,2Y0D6@28890|Euryarchaeota,244KC@183968|Thermococci	183968|Thermococci	K	Transcription elongation factor Spt4	spt4	-	2.7.7.6	ko:K03050	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	Spt4
PYH3_k127_4053370_6	436308.Nmar_1235	3.529e-58	207.0	COG1095@1|root,arCOG00675@2157|Archaea,41SGF@651137|Thaumarchaeota	651137|Thaumarchaeota	K	DNA-directed RNA polymerase	-	-	2.7.7.6	ko:K03049	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	S1,SHS2_Rpb7-N
PYH3_k127_4053370_16	591019.Shell_1635	1.93e-20	96.0	COG1412@1|root,arCOG04312@2157|Archaea,2XR40@28889|Crenarchaeota	28889|Crenarchaeota	V	SMART Nucleotide binding protein, PINc	-	-	-	ko:K07158	-	-	-	-	ko00000	-	-	-	Fcf1,PIN
PYH3_k127_4053370_2	573063.Metin_0173	6.393e-147	475.0	COG3276@1|root,arCOG01563@2157|Archaea,2XUKU@28890|Euryarchaeota,23QPD@183939|Methanococci	183939|Methanococci	J	eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA	eif2g	-	-	ko:K03242	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,eIF2_C
PYH3_k127_4053370_4	1131266.ARWQ01000001_gene1205	4.035e-106	354.0	COG0533@1|root,arCOG01183@2157|Archaea,41SDX@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37	kae1	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
PYH3_k127_4053370_7	529709.PYCH_18600	4.204e-50	185.0	COG0533@1|root,arCOG01185@2157|Archaea,2XX5D@28890|Euryarchaeota,2436E@183968|Thermococci	183968|Thermococci	T	serine threonine protein kinase	-	GO:0000408,GO:0002949,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360	2.7.11.1	ko:K08851	-	-	-	-	ko00000,ko01000,ko01001,ko03016	-	-	-	RIO1
PYH3_k127_4053370_9	589924.Ferp_1277	4.011e-44	167.0	COG0127@1|root,arCOG04184@2157|Archaea,2XTS4@28890|Euryarchaeota,24673@183980|Archaeoglobi	183980|Archaeoglobi	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	-	GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035870,GO:0036222,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
PYH3_k127_4053370_23	933801.Ahos_0782	5.842e-05	50.0	COG1522@1|root,arCOG01117@2157|Archaea,2XR1K@28889|Crenarchaeota	28889|Crenarchaeota	K	PFAM regulatory protein AsnC Lrp family	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
PYH3_k127_4053370_22	1045009.AFXQ01000001_gene2327	3.565e-08	57.0	COG1522@1|root,COG1522@2|Bacteria,2IQD4@201174|Actinobacteria,1W9QU@1268|Micrococcaceae	201174|Actinobacteria	K	AsnC family	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
PYH3_k127_4053370_3	523850.TON_1047	2.589e-108	361.0	COG0371@1|root,arCOG00982@2157|Archaea,2XT0F@28890|Euryarchaeota,243PT@183968|Thermococci	183968|Thermococci	C	Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea	egsA	-	1.1.1.261	ko:K00096	ko00564,map00564	-	R05679,R05680	RC00029	ko00000,ko00001,ko01000	-	-	-	Fe-ADH_2
PYH3_k127_4053370_12	1220534.B655_2010	1.021e-41	174.0	COG3356@1|root,arCOG04351@2157|Archaea,2XVEY@28890|Euryarchaeota,23NN7@183925|Methanobacteria	183925|Methanobacteria	S	Predicted membrane protein (DUF2070)	-	-	-	ko:K08979	-	-	-	-	ko00000	-	-	-	DUF2070
PYH3_k127_4053370_5	272844.PAB0735	2.742e-74	257.0	COG1646@1|root,arCOG01085@2157|Archaea,2XTEC@28890|Euryarchaeota,24399@183968|Thermococci	183968|Thermococci	H	Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids	-	GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763	2.5.1.41	ko:K17104	ko00564,map00564	-	R04158	RC01091	ko00000,ko00001,ko01000	-	-	-	PcrB
PYH3_k127_4053370_10	1056495.Calag_0209	4.172e-44	171.0	COG0382@1|root,arCOG00476@2157|Archaea,2XQNM@28889|Crenarchaeota	28889|Crenarchaeota	H	PFAM UbiA prenyltransferase	-	-	2.5.1.42	ko:K17105	ko00564,map00564	-	R04520	RC01171	ko00000,ko00001,ko01000	-	-	-	UbiA
PYH3_k127_4053370_1	1041930.Mtc_0274	9.284e-176	559.0	COG1257@1|root,arCOG04260@2157|Archaea,2XTV9@28890|Euryarchaeota	28890|Euryarchaeota	I	Belongs to the HMG-CoA reductase family	hmgA-1	-	1.1.1.88	ko:K00054	ko00900,ko01110,ko01130,map00900,map01110,map01130	-	R02081	RC00004,RC00644	ko00000,ko00001,ko01000	-	-	-	HMG-CoA_red
PYH3_k127_4053370_13	868131.MSWAN_1425	5.805e-30	122.0	COG1304@1|root,arCOG00613@2157|Archaea,2XT6H@28890|Euryarchaeota,23NQE@183925|Methanobacteria	183925|Methanobacteria	H	Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)	fni	-	5.3.3.2	ko:K01823	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00095,M00096,M00364,M00365,M00366,M00367	R01123	RC00455	ko00000,ko00001,ko00002,ko01000	-	-	-	FMN_dh
PYH3_k127_4178637_14	198094.BA_2346	0.0006898	49.0	COG0477@1|root,COG2814@2|Bacteria,1TQHD@1239|Firmicutes,4HBCZ@91061|Bacilli,1ZDDG@1386|Bacillus	91061|Bacilli	EGP	COG0477 Permeases of the major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like,MFS_3,Sugar_tr
PYH3_k127_4178637_12	399550.Smar_1074	9.414e-06	53.0	arCOG00022@1|root,arCOG00022@2157|Archaea,2XQTH@28889|Crenarchaeota	28889|Crenarchaeota	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
PYH3_k127_4178637_9	877455.Metbo_2019	1.03e-26	113.0	COG0640@1|root,arCOG00731@2157|Archaea,2XYSK@28890|Euryarchaeota	28890|Euryarchaeota	K	transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5
PYH3_k127_4178637_11	643648.Slip_1684	1.31e-12	71.0	2ED1S@1|root,336YP@2|Bacteria,1VJRI@1239|Firmicutes,24UCF@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_4178637_3	1229909.NSED_01090	2.792e-84	295.0	COG0124@1|root,arCOG00404@2157|Archaea,41S9T@651137|Thaumarchaeota	651137|Thaumarchaeota	J	histidyl-tRNA synthetase	-	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
PYH3_k127_4178637_10	342949.PNA2_0910	4.595e-20	97.0	COG1676@1|root,arCOG01701@2157|Archaea,2XTKB@28890|Euryarchaeota,243N3@183968|Thermococci	183968|Thermococci	J	Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp	endA	GO:0000213,GO:0000379,GO:0000394,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0004549,GO:0006139,GO:0006388,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008380,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016892,GO:0016894,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:0140101,GO:1901360	4.6.1.16	ko:K01170	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_int_endo,tRNA_int_endo_N
PYH3_k127_4178637_2	1459636.NTE_00969	2.037e-101	342.0	COG0182@1|root,arCOG01123@2157|Archaea,41SF9@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	-	-	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	-	IF-2B
PYH3_k127_4178637_5	1183377.Py04_1582	4.081e-58	211.0	COG0503@1|root,arCOG00031@2157|Archaea,2XTD2@28890|Euryarchaeota,242RK@183968|Thermococci	183968|Thermococci	F	Phosphoribosyl transferase domain	-	-	2.4.2.7	ko:K00759,ko:K09685	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko03000,ko04147	-	-	-	HTH_3,Pribosyltran
PYH3_k127_4178637_8	679926.Mpet_0677	6.265e-27	115.0	COG0717@1|root,arCOG04048@2157|Archaea,2Y071@28890|Euryarchaeota	28890|Euryarchaeota	F	Deoxycytidine triphosphate deaminase	dcd	-	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	dUTPase
PYH3_k127_4178637_7	330214.NIDE3885	1.763e-27	115.0	COG1765@1|root,COG1765@2|Bacteria	2|Bacteria	O	OsmC-like protein	ycaO	-	-	ko:K09136	-	-	-	-	ko00000,ko03009	-	-	-	OsmC,YcaO
PYH3_k127_4178637_4	1499967.BAYZ01000073_gene2028	9.514e-59	214.0	COG0040@1|root,COG0040@2|Bacteria	2|Bacteria	F	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity	hisG	GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG,HisG_C
PYH3_k127_4178637_6	1232410.KI421426_gene1402	1.321e-34	139.0	COG0494@1|root,COG0494@2|Bacteria,1RD2C@1224|Proteobacteria,42TAG@68525|delta/epsilon subdivisions,2WPRH@28221|Deltaproteobacteria,43SJK@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
PYH3_k127_4178637_0	1303518.CCALI_00921	4.834e-261	820.0	COG0556@1|root,COG0556@2|Bacteria	2|Bacteria	L	nucleotide-excision repair	uvrB	-	-	ko:K03702,ko:K08999	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
PYH3_k127_4178637_1	555079.Toce_1670	2.927e-195	621.0	COG0178@1|root,COG0178@2|Bacteria,1TPIJ@1239|Firmicutes,2485F@186801|Clostridia,42EYE@68295|Thermoanaerobacterales	186801|Clostridia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
PYH3_k127_4184440_2	269799.Gmet_2041	9.386e-32	139.0	COG0707@1|root,COG1819@1|root,COG0707@2|Bacteria,COG1819@2|Bacteria,1MW1K@1224|Proteobacteria,42Q6U@68525|delta/epsilon subdivisions,2WMIT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	CG	PFAM UDP-glucuronosyl UDP-glucosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tran_28_C
PYH3_k127_4184440_3	1280673.AUJJ01000018_gene997	7.269e-13	78.0	COG0778@1|root,COG0778@2|Bacteria,1V9VR@1239|Firmicutes,24Q35@186801|Clostridia	186801|Clostridia	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
PYH3_k127_4184440_0	660470.Theba_2261	1.439e-70	241.0	2DH26@1|root,2ZY4Z@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF3795)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3795
PYH3_k127_4184440_1	357808.RoseRS_3668	6.588e-51	184.0	COG0350@1|root,COG0350@2|Bacteria	2|Bacteria	L	methylated-DNA-[protein]-cysteine S-methyltransferase activity	ogt	-	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1,Methyltransf_1N
PYH3_k127_4350874_0	330779.Saci_0372	1.225e-196	633.0	COG0308@1|root,arCOG02969@2157|Archaea,2XRK6@28889|Crenarchaeota	28889|Crenarchaeota	E	peptide catabolic process	ape2	-	-	ko:K13722	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	ERAP1_C,Peptidase_M1
PYH3_k127_4350874_3	1232410.KI421413_gene576	1.493e-11	74.0	COG0655@1|root,COG0655@2|Bacteria,1RKK7@1224|Proteobacteria,42T1X@68525|delta/epsilon subdivisions,2WPCQ@28221|Deltaproteobacteria,43V03@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
PYH3_k127_4350874_2	523845.AQXV01000026_gene1469	1.383e-41	168.0	arCOG02545@1|root,arCOG02545@2157|Archaea	2157|Archaea	S	Periplasmic copper-binding protein (NosD)	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,NosD,PKD
PYH3_k127_4350874_1	395961.Cyan7425_2741	5.891e-98	327.0	COG1012@1|root,COG1012@2|Bacteria,1G1BD@1117|Cyanobacteria,3KGCF@43988|Cyanothece	1117|Cyanobacteria	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.16,1.2.1.20,1.2.1.3,1.2.1.39,1.2.1.79,1.2.1.8	ko:K00128,ko:K00130,ko:K00135,ko:K00138,ko:K00146	ko00010,ko00053,ko00071,ko00250,ko00260,ko00280,ko00310,ko00330,ko00340,ko00350,ko00360,ko00380,ko00410,ko00561,ko00620,ko00625,ko00643,ko00650,ko00760,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00250,map00260,map00280,map00310,map00330,map00340,map00350,map00360,map00380,map00410,map00561,map00620,map00625,map00643,map00650,map00760,map00903,map00981,map01100,map01110,map01120,map01130	M00027,M00135,M00555	R00264,R00631,R00710,R00711,R00713,R00714,R00904,R01752,R01986,R02401,R02536,R02549,R02565,R02566,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
PYH3_k127_4368098_2	429009.Adeg_0163	7.858e-33	139.0	COG1541@1|root,COG1541@2|Bacteria,1TQA1@1239|Firmicutes,248G9@186801|Clostridia,42EK2@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	paaK	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
PYH3_k127_4368098_3	509191.AEDB02000076_gene1453	1.359e-08	66.0	COG5542@1|root,COG5542@2|Bacteria	2|Bacteria	O	integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	Mannosyl_trans2,PMT_2
PYH3_k127_4368098_1	909663.KI867150_gene853	6.941e-115	376.0	COG1013@1|root,COG1013@2|Bacteria,1R5BF@1224|Proteobacteria,42MRV@68525|delta/epsilon subdivisions,2WK9C@28221|Deltaproteobacteria,2MR5B@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Pyruvate ferredoxin oxidoreductase beta subunit C terminal	porB	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFO_beta_C,TPP_enzyme_C
PYH3_k127_4368098_0	1094980.Mpsy_2769	3.582e-130	427.0	COG0674@1|root,arCOG01606@2157|Archaea,2XSUJ@28890|Euryarchaeota,2N91I@224756|Methanomicrobia	224756|Methanomicrobia	C	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR,POR_N
PYH3_k127_4505929_0	1122223.KB890687_gene2429	3.506e-36	149.0	COG0438@1|root,COG0438@2|Bacteria,1WKWC@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
PYH3_k127_4505929_1	478749.BRYFOR_07299	3.731e-36	151.0	COG1063@1|root,COG1063@2|Bacteria,1TPWP@1239|Firmicutes,24ATV@186801|Clostridia	186801|Clostridia	E	Psort location Cytoplasmic, score	ydjJ	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
PYH3_k127_4505929_2	1054217.TALC_01013	7.471e-24	105.0	COG2101@1|root,arCOG01764@2157|Archaea,2XTTR@28890|Euryarchaeota,241NQ@183967|Thermoplasmata	183967|Thermoplasmata	K	General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation	tbp	-	-	ko:K03120	ko03022,ko05016,ko05165,ko05166,ko05168,ko05169,ko05203,map03022,map05016,map05165,map05166,map05168,map05169,map05203	-	-	-	ko00000,ko00001,ko03000,ko03021	-	-	-	TBP
PYH3_k127_4534007_13	419665.Maeo_0931	2.798e-18	96.0	COG0620@1|root,arCOG01876@2157|Archaea,2XUCW@28890|Euryarchaeota,23QKE@183939|Methanococci	183939|Methanococci	E	PFAM Methionine synthase, vitamin-B12 independent	metE	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003871,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019752,GO:0032259,GO:0042084,GO:0042085,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0050667,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
PYH3_k127_4534007_17	797209.ZOD2009_04637	4.516e-05	56.0	COG2244@1|root,arCOG02209@2157|Archaea,2XVSG@28890|Euryarchaeota,23TS7@183963|Halobacteria	183963|Halobacteria	S	Membrane protein involved in the export of O-antigen and teichoic acid	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_C
PYH3_k127_4534007_10	386456.JQKN01000005_gene515	8.819e-32	133.0	COG0746@1|root,arCOG01872@2157|Archaea,2XWJR@28890|Euryarchaeota,23PNI@183925|Methanobacteria	183925|Methanobacteria	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	mobA	-	2.7.7.77	ko:K03752	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
PYH3_k127_4534007_15	1365176.N186_05755	2.088e-12	70.0	COG1826@1|root,arCOG02694@2157|Archaea,2XRB5@28889|Crenarchaeota	28889|Crenarchaeota	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	tatA	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
PYH3_k127_4534007_7	1220534.B655_0360	5.623e-51	192.0	COG1578@1|root,arCOG04410@2157|Archaea,2XWGU@28890|Euryarchaeota,23NZ1@183925|Methanobacteria	183925|Methanobacteria	S	Protein of unknown function DUF89	-	-	-	ko:K09116	-	-	-	-	ko00000	-	-	-	DUF89
PYH3_k127_4534007_5	368408.Tpen_0880	1.145e-66	234.0	COG0149@1|root,arCOG01087@2157|Archaea,2XPYA@28889|Crenarchaeota	28889|Crenarchaeota	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM,ThiG
PYH3_k127_4534007_1	368408.Tpen_0196	7.147e-163	519.0	COG1980@1|root,arCOG04180@2157|Archaea,2XPV4@28889|Crenarchaeota	28889|Crenarchaeota	G	Catalyzes two subsequent steps in gluconeogenesis the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P)	fbp	GO:0000287,GO:0003674,GO:0003824,GO:0004332,GO:0005488,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006740,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016829,GO:0016830,GO:0016832,GO:0019203,GO:0019318,GO:0019319,GO:0019362,GO:0019637,GO:0034641,GO:0042132,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044283,GO:0046364,GO:0046483,GO:0046496,GO:0046872,GO:0050308,GO:0051186,GO:0055086,GO:0055114,GO:0071704,GO:0072524,GO:1901360,GO:1901564,GO:1901576	3.1.3.11,4.1.2.13	ko:K01622	ko00010,ko00030,ko00051,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00003	R00762,R01068,R01070,R02568,R04780	RC00017,RC00438,RC00439	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_3
PYH3_k127_4534007_2	858215.Thexy_0814	8.875e-133	434.0	COG0057@1|root,COG0057@2|Bacteria,1TNYU@1239|Firmicutes,247IZ@186801|Clostridia,42F8D@68295|Thermoanaerobacterales	186801|Clostridia	C	TIGRFAM Glyceraldehyde-3-phosphate dehydrogenase, type I	gap	GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
PYH3_k127_4534007_8	1459636.NTE_03124	9.599e-41	164.0	COG0524@1|root,arCOG00014@2157|Archaea	2157|Archaea	G	Belongs to the carbohydrate kinase PfkB family	-	-	2.7.1.15	ko:K00852	ko00030,map00030	-	R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB,Regulator_TrmB,TrmB
PYH3_k127_4534007_3	374847.Kcr_1277	4.178e-128	424.0	COG2379@1|root,arCOG04170@2157|Archaea	2157|Archaea	G	Glycerate kinase	gck	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016491,GO:0016661,GO:0016662,GO:0016740,GO:0016772,GO:0043798,GO:0044237,GO:0055114	2.7.1.165	ko:K11529	ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200	M00346	R08572	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4147,MOFRL
PYH3_k127_4534007_4	374847.Kcr_1548	2.086e-115	381.0	COG1052@1|root,arCOG01755@2157|Archaea	2157|Archaea	C	D-isomer specific 2-hydroxyacid dehydrogenase	gyaR	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0016618,GO:0030267,GO:0044424,GO:0044444,GO:0044464,GO:0055114	1.1.1.26,1.1.1.29	ko:K00015,ko:K00018	ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200	M00346	R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko00002,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
PYH3_k127_4534007_6	401526.TcarDRAFT_2288	7.563e-64	226.0	COG1145@1|root,COG1145@2|Bacteria,1UIDU@1239|Firmicutes,4H7FN@909932|Negativicutes	909932|Negativicutes	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_4534007_14	696369.KI912183_gene2503	1.036e-15	78.0	2AV93@1|root,31M00@2|Bacteria,1V94N@1239|Firmicutes,251VU@186801|Clostridia,265SD@186807|Peptococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_4534007_9	401526.TcarDRAFT_2289	3.337e-37	144.0	2AV93@1|root,31M00@2|Bacteria,1V94N@1239|Firmicutes,4H7KF@909932|Negativicutes	909932|Negativicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_4534007_11	374847.Kcr_0276	5.724e-30	125.0	COG1142@1|root,arCOG01502@2157|Archaea	2157|Archaea	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	porF	-	-	ko:K00196	ko00633,ko00680,ko00720,ko01120,ko01200,map00633,map00680,map00720,map01120,map01200	-	R07157,R08034	RC00250,RC02800	ko00000,ko00001	-	-	-	Fer4,Fer4_11,Fer4_3,Fer4_4,Fer4_6,Fer4_9
PYH3_k127_4534007_16	768672.Desfe_0694	1.43e-05	51.0	COG1977@1|root,arCOG00536@2157|Archaea,2XRHB@28889|Crenarchaeota	28889|Crenarchaeota	H	TIGRFAM MoaD family protein	-	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
PYH3_k127_4534007_0	1449126.JQKL01000016_gene2854	5.851e-196	629.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,26A1J@186813|unclassified Clostridiales	186801|Clostridia	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
PYH3_k127_4534007_12	529709.PYCH_02430	3.143e-22	109.0	COG4346@1|root,arCOG00561@2157|Archaea,2XVUT@28890|Euryarchaeota,243GE@183968|Thermococci	183968|Thermococci	O	PFAM glycosyl transferase family 39	-	-	-	-	-	-	-	-	-	-	-	-	PMT
PYH3_k127_4678207_7	224324.aq_1607	2.53e-06	56.0	COG0717@1|root,COG0717@2|Bacteria,2G4WK@200783|Aquificae	200783|Aquificae	F	Belongs to the dCTP deaminase family	dcd	-	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	dUTPase
PYH3_k127_4678207_9	572478.Vdis_0993	0.0007529	49.0	arCOG06011@1|root,arCOG06011@2157|Archaea	2157|Archaea	S	Domain of unknown function (DUF4382)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4382
PYH3_k127_4678207_1	985053.VMUT_0350	7.052e-100	336.0	COG1013@1|root,arCOG01601@2157|Archaea,2XPQR@28889|Crenarchaeota	28889|Crenarchaeota	C	PFAM Thiamine pyrophosphate	-	-	1.2.7.1	ko:K00170	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
PYH3_k127_4678207_0	351627.Csac_1460	2.515e-117	389.0	COG0674@1|root,COG0674@2|Bacteria,1VS48@1239|Firmicutes,25E5U@186801|Clostridia,42EUF@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein	porA	-	1.2.7.1	ko:K00169	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
PYH3_k127_4678207_4	1365176.N186_03215	4.704e-31	123.0	COG1144@1|root,arCOG01605@2157|Archaea,2XR7D@28889|Crenarchaeota	28889|Crenarchaeota	C	oxidoreductase, delta subunit	-	-	1.2.7.1	ko:K00171	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4
PYH3_k127_4678207_3	1121459.AQXE01000010_gene1976	6.092e-52	189.0	COG1014@1|root,COG1014@2|Bacteria,1N12F@1224|Proteobacteria,42NN1@68525|delta/epsilon subdivisions,2WQFN@28221|Deltaproteobacteria,2M92T@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	-	-	1.2.7.1	ko:K00172	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,POR
PYH3_k127_4678207_6	591019.Shell_1488	1.957e-15	81.0	arCOG05517@1|root,arCOG05517@2157|Archaea,2XSGW@28889|Crenarchaeota	28889|Crenarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_4678207_5	1220534.B655_1656	6.264e-27	116.0	COG1986@1|root,arCOG01223@2157|Archaea,2XWGY@28890|Euryarchaeota,23P4J@183925|Methanobacteria	183925|Methanobacteria	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	-	2.7.7.3	ko:K02201	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
PYH3_k127_4678207_2	401526.TcarDRAFT_2161	6.345e-58	206.0	COG0163@1|root,COG0163@2|Bacteria,1V3JV@1239|Firmicutes,4H44P@909932|Negativicutes	909932|Negativicutes	H	Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN	ubiX	-	2.5.1.129	ko:K03186	ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220	M00117	R01238,R02952,R03367,R04985,R04986,R11225	RC00391,RC00814,RC03392	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavoprotein
PYH3_k127_4678207_8	745776.DGo_CA2737	4.929e-06	52.0	COG0043@1|root,COG0043@2|Bacteria,1WI75@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	H	Belongs to the UbiD family	vdcC	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
PYH3_k127_47656_1	1457250.BBMO01000002_gene2540	5.873e-57	219.0	COG1199@1|root,arCOG00770@2157|Archaea,2XSWZ@28890|Euryarchaeota,23S1B@183963|Halobacteria	183963|Halobacteria	K	COG1199 Rad3-related DNA helicases	-	-	-	-	-	-	-	-	-	-	-	-	DEAD_2,Helicase_C_2
PYH3_k127_47656_5	243233.MCA2192	1.416e-22	111.0	COG4346@1|root,COG4346@2|Bacteria	2|Bacteria	O	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	2.4.1.109	ko:K00728	ko00514,ko00515,ko01100,map00514,map00515,map01100	-	R04072,R07620,R11399	RC00005,RC00059,RC00397	ko00000,ko00001,ko01000,ko01003	-	GT39	-	GT87,PMT,PMT_2,PMT_4TMC
PYH3_k127_47656_6	1365176.N186_09185	1.327e-10	74.0	arCOG03671@1|root,arCOG10888@1|root,arCOG03671@2157|Archaea,arCOG10888@2157|Archaea	2157|Archaea	S	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	Thermopsin
PYH3_k127_47656_0	192952.MM_0946	2.456e-72	248.0	COG1853@1|root,arCOG02016@2157|Archaea,2XYAJ@28890|Euryarchaeota,2N9RF@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM flavin reductase domain protein, FMN-binding	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
PYH3_k127_47656_4	648996.Theam_1284	2.035e-29	125.0	COG1611@1|root,COG1611@2|Bacteria,2G4BX@200783|Aquificae	200783|Aquificae	S	Belongs to the LOG family	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	DNA_processg_A,Lysine_decarbox
PYH3_k127_47656_2	96561.Dole_0563	1.483e-37	148.0	2A4CF@1|root,30SY3@2|Bacteria,1RFXP@1224|Proteobacteria,42RIM@68525|delta/epsilon subdivisions,2WNS6@28221|Deltaproteobacteria,2MNMZ@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Yip1
PYH3_k127_47656_7	1123236.KB899386_gene1842	1.339e-08	65.0	COG0697@1|root,COG0697@2|Bacteria,1R4G2@1224|Proteobacteria,1S08Y@1236|Gammaproteobacteria,465ET@72275|Alteromonadaceae	1236|Gammaproteobacteria	EG	Transporter	-	-	-	-	-	-	-	-	-	-	-	-	EamA
PYH3_k127_47656_3	1089553.Tph_c23980	3.825e-34	140.0	COG0684@1|root,COG0684@2|Bacteria,1UZ9U@1239|Firmicutes,24ADH@186801|Clostridia,42G1P@68295|Thermoanaerobacterales	186801|Clostridia	H	PFAM Dimethylmenaquinone methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	RraA-like
PYH3_k127_4805996_5	387631.Asulf_00545	2.487e-66	233.0	COG4662@1|root,arCOG00166@2157|Archaea,2XTDY@28890|Euryarchaeota,24708@183980|Archaeoglobi	183980|Archaeoglobi	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K05773	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	BPD_transp_1
PYH3_k127_4805996_4	1343739.PAP_00375	4.822e-68	239.0	COG3839@1|root,arCOG00175@2157|Archaea,2Y7NF@28890|Euryarchaeota,242VD@183968|Thermococci	183968|Thermococci	G	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.55	ko:K06857	ko02010,map02010	M00186	R10531	RC00002	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	ABC_tran
PYH3_k127_4805996_3	1121957.ATVL01000011_gene3574	4.042e-77	273.0	COG0659@1|root,COG0659@2|Bacteria	2|Bacteria	P	secondary active sulfate transmembrane transporter activity	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	MFS_MOT1
PYH3_k127_4805996_2	415426.Hbut_0909	2.876e-77	273.0	COG1474@1|root,arCOG00467@2157|Archaea,2XPZB@28889|Crenarchaeota	28889|Crenarchaeota	L	Involved in regulation of DNA replication	cdc6-2	-	-	ko:K10725	-	-	-	-	ko00000,ko03032	-	-	-	AAA_22,Cdc6_C
PYH3_k127_4805996_10	109760.SPPG_05895T0	6.53e-08	63.0	COG0468@1|root,KOG1434@2759|Eukaryota,39J83@33154|Opisthokonta,3NVB0@4751|Fungi	4751|Fungi	L	Belongs to the RecA family	-	GO:0000003,GO:0000018,GO:0000150,GO:0000166,GO:0000217,GO:0000228,GO:0000280,GO:0000400,GO:0000709,GO:0000724,GO:0000725,GO:0000730,GO:0000793,GO:0000794,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003697,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005694,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006311,GO:0006312,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007049,GO:0007059,GO:0007127,GO:0007129,GO:0007130,GO:0007131,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0010520,GO:0010564,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0022402,GO:0022414,GO:0022607,GO:0030554,GO:0031323,GO:0031974,GO:0031981,GO:0032553,GO:0032555,GO:0032559,GO:0033043,GO:0033554,GO:0034622,GO:0034641,GO:0035639,GO:0035822,GO:0035825,GO:0036094,GO:0040020,GO:0042148,GO:0042623,GO:0042802,GO:0043142,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044464,GO:0044877,GO:0045003,GO:0045132,GO:0045143,GO:0046483,GO:0048285,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051128,GO:0051171,GO:0051259,GO:0051260,GO:0051276,GO:0051321,GO:0051445,GO:0051716,GO:0051726,GO:0051783,GO:0060255,GO:0060631,GO:0061982,GO:0065003,GO:0065004,GO:0065007,GO:0070013,GO:0070192,GO:0070193,GO:0071704,GO:0071824,GO:0071840,GO:0080090,GO:0090304,GO:0090735,GO:0097159,GO:0097367,GO:0098813,GO:0140013,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1903046,GO:1905334,GO:2000241	-	ko:K10872,ko:K14545	ko03008,ko04113,map03008,map04113	-	-	-	ko00000,ko00001,ko03009,ko03400	-	-	-	HHH_5,Rad51
PYH3_k127_4805996_11	880072.Desac_2172	8.974e-07	54.0	arCOG07300@1|root,2ZTGG@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_4805996_0	1459636.NTE_00007	1.297e-183	599.0	COG0417@1|root,arCOG00329@2157|Archaea	2157|Archaea	L	DNA polymerase elongation subunit (Family B)	polB2	-	2.7.7.7	ko:K02319	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_pol_B
PYH3_k127_4805996_9	1104324.P186_2618	1.74e-29	130.0	COG0668@1|root,arCOG01568@2157|Archaea,2XQVK@28889|Crenarchaeota	28889|Crenarchaeota	M	PFAM MscS Mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
PYH3_k127_4805996_1	868595.Desca_0924	4.268e-96	324.0	COG0535@1|root,COG0535@2|Bacteria,1TPZ4@1239|Firmicutes,249UR@186801|Clostridia,2606I@186807|Peptococcaceae	186801|Clostridia	S	Protein of unknown function (DUF3641)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3641,Fer4_12,Radical_SAM
PYH3_k127_4805996_7	521011.Mpal_2448	1.737e-50	187.0	COG0463@1|root,arCOG01381@2157|Archaea	2157|Archaea	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glycos_transf_2
PYH3_k127_4805996_8	644281.MFS40622_1443	6.076e-46	171.0	COG1036@1|root,arCOG01705@2157|Archaea,2XXGS@28890|Euryarchaeota,23QUS@183939|Methanococci	183939|Methanococci	C	TIGRFAM archaeoflavoprotein AfpA	-	-	-	-	-	-	-	-	-	-	-	-	Flavoprotein
PYH3_k127_4805996_6	340099.Teth39_0287	1.139e-62	222.0	COG0156@1|root,COG0156@2|Bacteria,1TPUX@1239|Firmicutes,2491D@186801|Clostridia,42FUG@68295|Thermoanaerobacterales	186801|Clostridia	H	PFAM Aminotransferase class I and II	kbl	GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008710,GO:0008890,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.3.1.29,2.3.1.47	ko:K00639,ko:K00652	ko00260,ko00780,ko01100,map00260,map00780,map01100	M00123,M00573,M00577	R00371,R03210,R10124	RC00004,RC00039,RC00394,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
PYH3_k127_4812740_0	694429.Pyrfu_0957	6.939e-200	640.0	COG2511@1|root,arCOG01719@2157|Archaea,2XPPH@28889|Crenarchaeota	28889|Crenarchaeota	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate	gatE	GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.3.5.7	ko:K03330	ko00970,ko01100,map00970,map01100	-	R03905	RC00010	ko00000,ko00001,ko01000	-	-	-	GAD,GatB_N,GatB_Yqey
PYH3_k127_4812740_1	1006006.Mcup_0508	8.638e-36	138.0	COG0252@1|root,arCOG01924@2157|Archaea,2XPTP@28889|Crenarchaeota	28889|Crenarchaeota	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate	gatD	-	6.3.5.7	ko:K09482	ko00970,ko01100,map00970,map01100	-	R03905	RC00010	ko00000,ko00001,ko01000	-	-	-	Asparaginase
PYH3_k127_4862320_25	1198449.ACAM_1275	0.000958	45.0	COG0620@1|root,arCOG01876@2157|Archaea,2XPKF@28889|Crenarchaeota	28889|Crenarchaeota	E	Catalyzes the transfer of a methyl group to L- homocysteine resulting in methionine formation. The physiological methyl donor is	metE	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003871,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019752,GO:0032259,GO:0042084,GO:0042085,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0050667,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
PYH3_k127_4862320_1	868131.MSWAN_0996	8.15e-159	510.0	COG1104@1|root,arCOG00066@2157|Archaea,2Y7J8@28890|Euryarchaeota,23NPK@183925|Methanobacteria	183925|Methanobacteria	E	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
PYH3_k127_4862320_20	411468.CLOSCI_02828	2.845e-28	126.0	COG0348@1|root,COG0348@2|Bacteria,1TPHF@1239|Firmicutes,247KH@186801|Clostridia,21YNG@1506553|Lachnoclostridium	186801|Clostridia	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_5
PYH3_k127_4862320_15	1459636.NTE_03146	1.249e-44	169.0	COG0071@1|root,arCOG01833@2157|Archaea	2157|Archaea	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
PYH3_k127_4862320_19	1410624.JNKK01000001_gene590	1.262e-30	134.0	COG1475@1|root,COG1475@2|Bacteria,1TQ2B@1239|Firmicutes,249VV@186801|Clostridia,27IWA@186928|unclassified Lachnospiraceae	186801|Clostridia	K	ParB-like nuclease domain	spo0J	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
PYH3_k127_4862320_3	415426.Hbut_1178	5.695e-131	441.0	COG0018@1|root,arCOG00487@2157|Archaea,2XPXC@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the class-I aminoacyl-tRNA synthetase family	argS	GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
PYH3_k127_4862320_23	1163730.FFONT_0808	3.354e-22	97.0	COG1522@1|root,arCOG01117@2157|Archaea,2XR1K@28889|Crenarchaeota	28889|Crenarchaeota	K	PFAM regulatory protein AsnC Lrp family	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
PYH3_k127_4862320_14	574087.Acear_0986	1.144e-50	189.0	COG3640@1|root,COG3640@2|Bacteria,1TPCY@1239|Firmicutes,247JM@186801|Clostridia	186801|Clostridia	D	CobQ CobB MinD ParA nucleotide binding domain	cooC	-	-	ko:K07321	-	-	-	-	ko00000	-	-	-	CbiA
PYH3_k127_4862320_11	1292035.H476_0413	4.512e-68	243.0	COG0685@1|root,COG0685@2|Bacteria,1UHX4@1239|Firmicutes,25E62@186801|Clostridia,25R45@186804|Peptostreptococcaceae	186801|Clostridia	E	Methylenetetrahydrofolate reductase	metF	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
PYH3_k127_4862320_12	748727.CLJU_c37620	8.132e-63	222.0	COG4656@1|root,COG4656@2|Bacteria,1TS9H@1239|Firmicutes,24DQ7@186801|Clostridia,36H5R@31979|Clostridiaceae	186801|Clostridia	C	Methylene-tetrahydrofolate reductase C terminal	-	-	-	-	-	-	-	-	-	-	-	iHN637.CLJU_RS18525	MTHFR_C
PYH3_k127_4862320_4	573064.Mefer_0567	1.42e-107	364.0	COG0446@1|root,arCOG01069@2157|Archaea,2XT0A@28890|Euryarchaeota,23Q75@183939|Methanococci	183939|Methanococci	P	FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.6.3.3	ko:K17870	-	-	-	-	ko00000,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
PYH3_k127_4862320_8	387631.Asulf_01966	9.877e-88	299.0	COG3252@1|root,arCOG02675@2157|Archaea,2XUB2@28890|Euryarchaeota,2460U@183980|Archaeoglobi	183980|Archaeoglobi	H	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT	mch	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	3.5.4.27	ko:K01499	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03464	RC01870	ko00000,ko00001,ko00002,ko01000	-	-	-	MCH
PYH3_k127_4862320_16	386456.JQKN01000009_gene1140	1.167e-42	166.0	COG2218@1|root,arCOG00097@2157|Archaea,2XWD0@28890|Euryarchaeota,23NYT@183925|Methanobacteria	183925|Methanobacteria	C	formylmethanofuran dehydrogenase, subunit C	fwdC	-	1.2.7.12	ko:K00202	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060,R11743	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	GXGXG
PYH3_k127_4862320_0	573064.Mefer_0155	6.257e-195	623.0	COG1229@1|root,arCOG04461@2157|Archaea,2XV5V@28890|Euryarchaeota,23QNZ@183939|Methanococci	183939|Methanococci	C	PFAM Amidohydrolase 3	fwdA	-	1.2.7.12	ko:K00200	ko00680,ko01100,ko01120,ko01130,ko01200,map00680,map01100,map01120,map01130,map01200	M00567	R03015,R08060	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_3
PYH3_k127_4862320_2	644281.MFS40622_0826	2.209e-144	469.0	COG1029@1|root,arCOG01499@2157|Archaea,2XTPW@28890|Euryarchaeota,23Q0U@183939|Methanococci	183939|Methanococci	C	TIGRFAM formylmethanofuran dehydrogenase subunit B	-	-	1.2.7.12	ko:K00201	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Molybdopterin
PYH3_k127_4862320_22	323259.Mhun_1984	7.891e-25	109.0	COG1153@1|root,arCOG02674@2157|Archaea,2XXYM@28890|Euryarchaeota,2NB08@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM molydopterin dinucleotide-binding region	fwdD-1	-	1.2.7.12	ko:K00203	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060,R11743	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Molydop_binding
PYH3_k127_4862320_9	1286171.EAL2_c10130	7.338e-78	270.0	COG0413@1|root,COG0413@2|Bacteria,1TPZA@1239|Firmicutes,248RR@186801|Clostridia,25V3K@186806|Eubacteriaceae	186801|Clostridia	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
PYH3_k127_4862320_7	868595.Desca_2548	6.004e-88	301.0	COG3958@1|root,COG3958@2|Bacteria,1V0K5@1239|Firmicutes,24914@186801|Clostridia,26093@186807|Peptococcaceae	186801|Clostridia	G	PFAM Transketolase, C-terminal domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
PYH3_k127_4862320_10	697281.Mahau_0475	3.859e-74	258.0	COG3959@1|root,COG3959@2|Bacteria,1TT51@1239|Firmicutes,247IK@186801|Clostridia,42EYC@68295|Thermoanaerobacterales	186801|Clostridia	G	PFAM Transketolase	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
PYH3_k127_4862320_24	1105031.HMPREF1141_1232	8.598e-12	71.0	COG1661@1|root,COG1661@2|Bacteria,1VBWE@1239|Firmicutes,24HQ2@186801|Clostridia,36K5V@31979|Clostridiaceae	186801|Clostridia	S	Domain of unknown function (DUF296)	-	-	-	ko:K06934	-	-	-	-	ko00000	-	-	-	DUF296
PYH3_k127_4862320_6	589924.Ferp_1018	1.044e-91	310.0	COG1927@1|root,arCOG04382@2157|Archaea,2XUX3@28890|Euryarchaeota,24626@183980|Archaeoglobi	183980|Archaeoglobi	C	Catalyzes the oxidation of methylene-H(4)MPT to methenyl-H(4)MPT( )	mtd	-	1.5.98.1	ko:K00319	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R04456	RC00202	ko00000,ko00001,ko00002,ko01000	-	-	-	MTD
PYH3_k127_4862320_5	573063.Metin_0870	1.033e-96	325.0	COG2037@1|root,arCOG02695@2157|Archaea,2XT8E@28890|Euryarchaeota,23Q6M@183939|Methanococci	183939|Methanococci	H	Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) so as to produce 5-formyl tetrahydromethanopterin (5- formyl-H(4)MPT) and methanofuran (MFR)	ftr	-	2.3.1.101	ko:K00672	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03390	RC00197,RC00870,RC02881	ko00000,ko00001,ko00002,ko01000	-	-	-	FTR,FTR_C
PYH3_k127_4862320_17	386456.JQKN01000016_gene901	1.848e-41	166.0	COG1665@1|root,arCOG01831@2157|Archaea,2XVY6@28890|Euryarchaeota,23NTJ@183925|Methanobacteria	183925|Methanobacteria	S	DNA polymerase beta domain protein region	-	-	-	ko:K09717	-	-	-	-	ko00000	-	-	-	-
PYH3_k127_4862320_13	877455.Metbo_1082	8.843e-63	227.0	COG1767@1|root,arCOG04238@2157|Archaea,2XT6S@28890|Euryarchaeota,23P0Y@183925|Methanobacteria	183925|Methanobacteria	H	ATP dephospho-CoA triphosphoribosyl transferase	citG	-	2.4.2.52	ko:K05966	ko02020,map02020	-	R09675	RC00049,RC00063	ko00000,ko00001,ko01000	-	-	-	CitG
PYH3_k127_4862320_18	386456.JQKN01000001_gene2134	1.135e-40	162.0	COG4071@1|root,arCOG02715@2157|Archaea,2XUMN@28890|Euryarchaeota,23NY6@183925|Methanobacteria	183925|Methanobacteria	H	F420-0:Gamma-glutamyl ligase	-	-	-	-	-	-	-	-	-	-	-	-	F420_ligase
PYH3_k127_4862320_21	592015.HMPREF1705_02186	3.852e-25	111.0	COG0189@1|root,COG0189@2|Bacteria,3TBW9@508458|Synergistetes	508458|Synergistetes	HJ	Prokaryotic glutathione synthetase, ATP-grasp domain	-	-	-	-	-	-	-	-	-	-	-	-	RimK
PYH3_k127_4870195_0	368408.Tpen_0393	1.122e-191	619.0	COG0417@1|root,arCOG00328@2157|Archaea,2XPM8@28889|Crenarchaeota	28889|Crenarchaeota	L	TIGRFAM DNA polymerase (pol2)	-	-	2.7.7.7	ko:K02319	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_pol_B,DNA_pol_B_exo1
PYH3_k127_4870195_1	272557.APE_2096.1	5.994e-19	89.0	COG0358@1|root,arCOG04281@2157|Archaea,2XPXM@28889|Crenarchaeota	28889|Crenarchaeota	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	Toprim_4
PYH3_k127_4973036_0	453591.Igni_0623	6.007e-109	365.0	COG0381@1|root,arCOG01392@2157|Archaea,2XQ7Q@28889|Crenarchaeota	28889|Crenarchaeota	M	UDP-N-acetylglucosamine 2-epimerase	-	-	5.1.3.14	ko:K01791	ko00520,ko01100,ko05111,map00520,map01100,map05111	M00362	R00420	RC00290	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase_2
PYH3_k127_4973036_1	365528.KB891220_gene1174	2.541e-48	190.0	COG1215@1|root,COG1215@2|Bacteria,2I5R7@201174|Actinobacteria	201174|Actinobacteria	M	Glycosyl transferase family group 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glyco_trans_2_3
PYH3_k127_4973036_3	1410653.JHVC01000001_gene1544	6.714e-13	82.0	COG5298@1|root,COG5298@2|Bacteria,1TSDC@1239|Firmicutes,25E03@186801|Clostridia,36FPX@31979|Clostridiaceae	186801|Clostridia	S	Uncharacterized protein conserved in bacteria (DUF2334)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2334
PYH3_k127_5069944_2	523845.AQXV01000053_gene664	3.887e-99	333.0	COG0043@1|root,arCOG01671@2157|Archaea,2XUDW@28890|Euryarchaeota,23Q1S@183939|Methanococci	183939|Methanococci	H	TIGRFAM UbiD family decarboxylase	-	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044464	-	-	-	-	-	-	-	-	-	-	UbiD
PYH3_k127_5069944_0	573063.Metin_0709	1.445e-116	388.0	COG1679@1|root,arCOG04278@2157|Archaea,2XTY6@28890|Euryarchaeota,23QFZ@183939|Methanococci	183939|Methanococci	S	Protein of unknown function (DUF521)	-	-	-	ko:K09123	-	-	-	-	ko00000	-	-	-	DUF521
PYH3_k127_5069944_3	269797.Mbar_A0718	1.927e-38	148.0	COG1786@1|root,arCOG04279@2157|Archaea,2XYXJ@28890|Euryarchaeota,2N9R7@224756|Methanomicrobia	224756|Methanomicrobia	C	Belongs to the UPF0107 family	-	-	-	ko:K09128	-	-	-	-	ko00000	-	-	-	DUF126
PYH3_k127_5069944_1	1459636.NTE_01473	1.838e-107	356.0	COG1405@1|root,arCOG01981@2157|Archaea,41SXZ@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	-	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
PYH3_k127_5069944_4	224719.Abm4_1269	2.259e-30	123.0	COG0023@1|root,arCOG04223@2157|Archaea,2XXW5@28890|Euryarchaeota,23PKF@183925|Methanobacteria	183925|Methanobacteria	J	Belongs to the SUI1 family	-	-	-	ko:K03113	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	SUI1
PYH3_k127_5069944_7	1280.SAXN108_2806	6.547e-08	64.0	COG0110@1|root,COG0110@2|Bacteria,1TQEX@1239|Firmicutes,4HGH2@91061|Bacilli,4H1ED@90964|Staphylococcaceae	91061|Bacilli	S	Maltose acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep,Hexapep_2,Mac
PYH3_k127_5069944_5	572478.Vdis_0458	8.099e-23	109.0	COG0463@1|root,arCOG01385@2157|Archaea	2157|Archaea	M	COG0463 Glycosyltransferases involved in cell wall biogenesis	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
PYH3_k127_5069944_6	797302.Halru_0995	1.311e-11	72.0	arCOG01792@1|root,arCOG01792@2157|Archaea	2157|Archaea	K	Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
PYH3_k127_5069944_8	546270.GEMHA0001_1085	1.419e-07	63.0	COG1215@1|root,COG1215@2|Bacteria,1U4ZW@1239|Firmicutes,4HBT3@91061|Bacilli	91061|Bacilli	M	group 2 family protein	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
PYH3_k127_5091269_1	1343739.PAP_00020	7.503e-210	680.0	COG1372@1|root,COG1933@1|root,arCOG03145@2157|Archaea,arCOG04447@2157|Archaea,2XU5S@28890|Euryarchaeota,24309@183968|Thermococci	183968|Thermococci	L	Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase	polC	GO:0003674,GO:0005488,GO:0005515,GO:0042802	2.7.7.7	ko:K02322	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	M00264	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	Intein_splicing,LAGLIDADG_3,PolC_DP2
PYH3_k127_5091269_26	555779.Dthio_PD2721	0.0006493	51.0	28K33@1|root,2Z9SC@2|Bacteria,1Q1U9@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_5091269_13	580331.Thit_0099	4.669e-38	152.0	COG0084@1|root,COG0084@2|Bacteria,1TNY1@1239|Firmicutes,248HE@186801|Clostridia,42FZQ@68295|Thermoanaerobacterales	186801|Clostridia	L	TIGRFAM hydrolase, TatD family	yabD	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
PYH3_k127_5091269_20	953739.SVEN_1801	1.412e-13	79.0	COG0705@1|root,COG0705@2|Bacteria,2GNPK@201174|Actinobacteria	201174|Actinobacteria	S	PFAM Rhomboid family protein	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
PYH3_k127_5091269_22	985053.VMUT_1615	5.73e-10	63.0	COG4888@1|root,arCOG04136@2157|Archaea,2XRI7@28889|Crenarchaeota	28889|Crenarchaeota	J	Transcription elongation factor Elf1 like	-	-	-	-	-	-	-	-	-	-	-	-	Elf1
PYH3_k127_5091269_12	457570.Nther_2211	1.707e-55	203.0	COG1975@1|root,COG1975@2|Bacteria,1URM5@1239|Firmicutes,24AHV@186801|Clostridia	186801|Clostridia	O	XanTHIne and CO dehydrogenases maturation factor, XdhC CoxF family	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI
PYH3_k127_5091269_17	572546.Arcpr_1468	3.564e-28	119.0	COG0171@1|root,COG1372@1|root,arCOG00069@2157|Archaea,arCOG03145@2157|Archaea,2XT7M@28890|Euryarchaeota,24632@183980|Archaeoglobi	183980|Archaeoglobi	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source	nadE	-	6.3.1.5	ko:K01916	ko00760,ko01100,map00760,map01100	M00115	R00189	RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	NAD_synthase
PYH3_k127_5091269_15	985053.VMUT_0432	3.017e-30	124.0	COG0171@1|root,arCOG00069@2157|Archaea,2XQ3J@28889|Crenarchaeota	28889|Crenarchaeota	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source	nadE	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.1.5	ko:K01916	ko00760,ko01100,map00760,map01100	M00115	R00189	RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	NAD_synthase
PYH3_k127_5091269_11	1444306.JFZC01000012_gene2013	1.538e-55	204.0	COG0388@1|root,COG0388@2|Bacteria,1V4HM@1239|Firmicutes,4IQ6E@91061|Bacilli	91061|Bacilli	S	Carbon-nitrogen hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
PYH3_k127_5091269_21	1459636.NTE_00083	1.598e-13	76.0	arCOG04038@1|root,arCOG04038@2157|Archaea,41SQU@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_5091269_0	880072.Desac_1143	0.0	1093.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,42NDJ@68525|delta/epsilon subdivisions,2WJSH@28221|Deltaproteobacteria,2MQB6@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
PYH3_k127_5091269_5	593117.TGAM_0128	3.026e-118	394.0	COG1474@1|root,arCOG00467@2157|Archaea,2XU73@28890|Euryarchaeota,242PQ@183968|Thermococci	183968|Thermococci	L	Involved in regulation of DNA replication	cdc6	-	-	ko:K10725	-	-	-	-	ko00000,ko03032	-	-	-	AAA,AAA_16,Cdc6_C
PYH3_k127_5091269_8	1041930.Mtc_0452	1.383e-98	340.0	COG1311@1|root,arCOG04455@2157|Archaea,2XSUG@28890|Euryarchaeota,2N96N@224756|Methanomicrobia	224756|Methanomicrobia	L	Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase	polB	-	2.7.7.7	ko:K02323	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	M00264	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	DNA_pol_E_B,Metallophos,tRNA_anti-codon
PYH3_k127_5091269_3	342949.PNA2_1872	6.157e-135	445.0	COG1530@1|root,arCOG00321@2157|Archaea,2XU9U@28890|Euryarchaeota,243NV@183968|Thermococci	183968|Thermococci	L	Putative modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
PYH3_k127_5091269_7	391623.TERMP_00332	2.824e-102	347.0	COG0312@1|root,arCOG00322@2157|Archaea,2XVT5@28890|Euryarchaeota,2435V@183968|Thermococci	183968|Thermococci	S	Putative modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
PYH3_k127_5091269_19	1365176.N186_07420	1.445e-21	101.0	COG2606@1|root,arCOG04332@2157|Archaea	2157|Archaea	S	YbaK prolyl-tRNA synthetase associated	ybaK	-	-	ko:K03976	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_edit
PYH3_k127_5091269_9	478749.BRYFOR_08002	2.968e-84	291.0	COG2220@1|root,COG2220@2|Bacteria,1TSFV@1239|Firmicutes,249MG@186801|Clostridia	186801|Clostridia	S	Beta-lactamase superfamily domain	ulaG	-	-	ko:K03476	ko00053,ko01100,ko01120,map00053,map01100,map01120	M00550	R07677	RC02793	ko00000,ko00001,ko00002,ko01000	-	-	-	Lactamase_B_2,Lactamase_B_3
PYH3_k127_5091269_18	696281.Desru_1598	1.371e-26	114.0	COG0589@1|root,COG0589@2|Bacteria,1VEJR@1239|Firmicutes,24QQ6@186801|Clostridia,262ZF@186807|Peptococcaceae	186801|Clostridia	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
PYH3_k127_5091269_2	351160.RCIX231	2.676e-206	674.0	COG1201@1|root,arCOG00557@2157|Archaea,2XSTH@28890|Euryarchaeota,2N90P@224756|Methanomicrobia	224756|Methanomicrobia	L	DEAD DEAH box helicase domain protein	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
PYH3_k127_5091269_6	589924.Ferp_0652	7.13e-104	348.0	COG0123@1|root,arCOG00324@2157|Archaea,2XT0B@28890|Euryarchaeota,246V5@183980|Archaeoglobi	183980|Archaeoglobi	BQ	PFAM histone deacetylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
PYH3_k127_5091269_14	1094980.Mpsy_1791	1.42e-32	144.0	COG1599@1|root,arCOG01510@2157|Archaea,2XTJP@28890|Euryarchaeota,2N93V@224756|Methanomicrobia	224756|Methanomicrobia	L	PFAM nucleic acid binding, OB-fold, tRNA helicase-type	-	-	-	ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko03000,ko03032,ko03400	-	-	-	tRNA_anti-codon
PYH3_k127_5091269_10	1229909.NSED_09885	4.157e-63	225.0	COG0177@1|root,arCOG00459@2157|Archaea,41SFM@651137|Thaumarchaeota	651137|Thaumarchaeota	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
PYH3_k127_5091269_4	247490.KSU1_D0451	5.199e-121	398.0	COG1899@1|root,COG1899@2|Bacteria,2IY4N@203682|Planctomycetes	203682|Planctomycetes	O	Deoxyhypusine synthase	-	-	2.5.1.46	ko:K00809	-	-	-	-	ko00000,ko01000	-	-	-	DS
PYH3_k127_5091269_23	591019.Shell_0769	7.311e-10	63.0	COG2388@1|root,arCOG03647@2157|Archaea,2XR3B@28889|Crenarchaeota	28889|Crenarchaeota	S	GCN5-related N-acetyl-transferase	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_5091269_25	351160.RCIX663	0.0002209	47.0	COG1763@1|root,arCOG00532@2157|Archaea	2157|Archaea	H	molybdopterin-guanine dinucleotide biosynthesis protein	mobB	-	2.8.1.12	ko:K03635,ko:K03753	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	FeS,MobB
PYH3_k127_5091269_16	1131266.ARWQ01000002_gene497	6.888e-29	117.0	COG0760@1|root,arCOG07441@2157|Archaea,41SSK@651137|Thaumarchaeota	651137|Thaumarchaeota	O	PPIC-type PPIASE domain	-	-	5.2.1.8	ko:K07533	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase_3
PYH3_k127_5091269_24	1391647.AVSV01000003_gene1570	9.728e-05	45.0	COG0251@1|root,COG0251@2|Bacteria,1V6HG@1239|Firmicutes,24J8Y@186801|Clostridia,36JHE@31979|Clostridiaceae	186801|Clostridia	J	endoribonuclease L-PSP	yjgF	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
PYH3_k127_5175816_15	1120985.AUMI01000021_gene2791	8.961e-32	130.0	COG1661@1|root,COG1661@2|Bacteria,1VIGP@1239|Firmicutes	1239|Firmicutes	S	Domain of unknown function (DUF296)	-	-	-	-	-	-	-	-	-	-	-	-	DUF296
PYH3_k127_5175816_1	374847.Kcr_0825	9.512e-72	249.0	COG0410@1|root,arCOG00924@2157|Archaea	2157|Archaea	E	ABC-type branched-chain amino acid transport systems ATPase component	livF5	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
PYH3_k127_5175816_2	374847.Kcr_0826	3.023e-70	245.0	COG0411@1|root,arCOG00926@2157|Archaea	2157|Archaea	E	COG0411 ABC-type branched-chain amino acid transport systems ATPase component	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
PYH3_k127_5175816_9	1158318.ATXC01000001_gene306	2.206e-48	185.0	COG4177@1|root,COG4177@2|Bacteria,2G5A3@200783|Aquificae	200783|Aquificae	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
PYH3_k127_5175816_10	675635.Psed_3734	3.367e-48	184.0	COG0559@1|root,COG0559@2|Bacteria,2GKAR@201174|Actinobacteria,4E4VX@85010|Pseudonocardiales	201174|Actinobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
PYH3_k127_5175816_3	589924.Ferp_1683	2.604e-61	228.0	COG0683@1|root,arCOG01020@2157|Archaea,2XVWV@28890|Euryarchaeota,245XV@183980|Archaeoglobi	183980|Archaeoglobi	E	Periplasmic binding protein domain	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
PYH3_k127_5175816_8	926569.ANT_22050	5.692e-49	183.0	COG3260@1|root,COG3260@2|Bacteria,2G8XX@200795|Chloroflexi	200795|Chloroflexi	C	NADH ubiquinone oxidoreductase, 20 Kd subunit	echC	-	-	ko:K14088	-	-	-	-	ko00000	-	-	-	Oxidored_q6
PYH3_k127_5175816_17	649764.HMPREF0762_01011	1.356e-24	113.0	COG1143@1|root,COG1143@2|Bacteria,2GJNU@201174|Actinobacteria,4CW59@84998|Coriobacteriia	84998|Coriobacteriia	C	4Fe-4S dicluster domain	-	-	-	ko:K12143	-	-	-	-	ko00000	-	-	-	Fer4,Fer4_7
PYH3_k127_5175816_6	246194.CHY_1831	1.313e-60	220.0	COG1005@1|root,COG1005@2|Bacteria,1TQNU@1239|Firmicutes,25E6Z@186801|Clostridia,42JFJ@68295|Thermoanaerobacterales	186801|Clostridia	C	NADH dehydrogenase	-	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
PYH3_k127_5175816_0	338966.Ppro_3524	3.915e-111	370.0	COG3261@1|root,COG3261@2|Bacteria,1QUBF@1224|Proteobacteria,43DST@68525|delta/epsilon subdivisions,2WJ4E@28221|Deltaproteobacteria,43TGG@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	PFAM NADH-ubiquinone oxidoreductase, chain 49kDa	-	-	1.6.5.3	ko:K00333,ko:K14090	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa,NiFeSe_Hases
PYH3_k127_5175816_5	579137.Metvu_0280	8.53e-61	220.0	COG2048@1|root,arCOG00338@2157|Archaea,2XTWJ@28890|Euryarchaeota,23Q3U@183939|Methanococci	183939|Methanococci	C	heterodisulfide reductase, subunit B	hdrB2	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
PYH3_k127_5175816_23	1120977.JHUX01000003_gene1828	0.0003153	51.0	COG0649@1|root,COG0852@1|root,COG0649@2|Bacteria,COG0852@2|Bacteria,1MVIN@1224|Proteobacteria,1RM98@1236|Gammaproteobacteria,3NKS1@468|Moraxellaceae	1236|Gammaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:0098797,GO:0098803,GO:1901135,GO:1901360,GO:1901564,GO:1902494,GO:1990204	1.6.5.3	ko:K13378	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iECDH10B_1368.ECDH10B_2448,iECDH1ME8569_1439.ECDH1ME8569_2223,iETEC_1333.ETEC_2421,iEcDH1_1363.EcDH1_1371,iPC815.YPO2553,iUMNK88_1353.UMNK88_2836	Complex1_30kDa,Complex1_49kDa
PYH3_k127_5175816_14	304371.MCP_2644	2.245e-38	149.0	COG0437@1|root,arCOG01500@2157|Archaea,2Y7H8@28890|Euryarchaeota,2NB5B@224756|Methanomicrobia	224756|Methanomicrobia	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_6
PYH3_k127_5175816_20	861299.J421_3199	5.421e-14	77.0	COG0824@1|root,COG0824@2|Bacteria,1ZTY3@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Thioesterase-like superfamily	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT
PYH3_k127_5175816_22	522772.Dacet_2830	4.774e-08	55.0	COG0537@1|root,COG0537@2|Bacteria,2GFI1@200930|Deferribacteres	200930|Deferribacteres	FG	Protein similar to CwfJ C-terminus 1	-	-	2.7.7.53	ko:K19710	ko00230,map00230	-	R00126,R01618	RC00002,RC02753,RC02795	ko00000,ko00001,ko01000	-	-	-	HIT
PYH3_k127_5175816_19	521011.Mpal_1670	2.821e-16	80.0	COG0425@1|root,arCOG02062@2157|Archaea	2157|Archaea	O	redox protein regulator of disulfide bond formation	-	-	-	-	-	-	-	-	-	-	-	-	TusA
PYH3_k127_5175816_4	565033.GACE_1086	4.131e-61	212.0	COG0822@1|root,arCOG02077@2157|Archaea,2XX32@28890|Euryarchaeota,2467Y@183980|Archaeoglobi	183980|Archaeoglobi	C	NifU-like N terminal domain	-	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
PYH3_k127_5175816_16	243164.DET0395	5.76e-25	112.0	COG0637@1|root,COG1214@1|root,COG0637@2|Bacteria,COG1214@2|Bacteria,2G6ZZ@200795|Chloroflexi,34D2B@301297|Dehalococcoidia	301297|Dehalococcoidia	O	Glycoprotease family	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2,Peptidase_M22
PYH3_k127_5175816_13	1408422.JHYF01000003_gene903	4.986e-44	170.0	COG1526@1|root,COG1526@2|Bacteria,1TU8R@1239|Firmicutes,24G61@186801|Clostridia,36HJU@31979|Clostridiaceae	186801|Clostridia	C	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH	fdhD	-	-	ko:K02379	-	-	-	-	ko00000	-	-	-	FdhD-NarQ
PYH3_k127_5175816_21	224325.AF_0566	2.762e-11	68.0	COG2522@1|root,arCOG00017@2157|Archaea,2Y7D1@28890|Euryarchaeota,246J1@183980|Archaeoglobi	183980|Archaeoglobi	K	Transcriptional regulator	-	-	-	ko:K07108	-	-	-	-	ko00000	-	-	-	HTH_3
PYH3_k127_5175816_11	909663.KI867150_gene2911	1.35e-47	185.0	COG0006@1|root,COG0006@2|Bacteria,1QNPN@1224|Proteobacteria,431BA@68525|delta/epsilon subdivisions,2WW9X@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Creatinase/Prolidase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Creatinase_N,Peptidase_M24
PYH3_k127_5175816_7	558169.AGAV01000018_gene3462	1.794e-60	220.0	COG0388@1|root,COG0388@2|Bacteria,1TQR9@1239|Firmicutes,4HDUI@91061|Bacilli	91061|Bacilli	S	Carbon-nitrogen hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
PYH3_k127_5175816_18	589924.Ferp_2452	8.609e-20	94.0	COG0727@1|root,arCOG02579@2157|Archaea,2XZM5@28890|Euryarchaeota,246D5@183980|Archaeoglobi	183980|Archaeoglobi	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
PYH3_k127_5175816_12	694429.Pyrfu_1477	2.265e-45	173.0	COG1100@1|root,arCOG01225@2157|Archaea,2XPWA@28889|Crenarchaeota	28889|Crenarchaeota	S	COG1100 GTPase SAR1 and related small G	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	ATP_bind_1
PYH3_k127_5216506_4	647113.Metok_0784	1.748e-31	129.0	COG2147@1|root,arCOG04089@2157|Archaea,2XWU1@28890|Euryarchaeota,23QT2@183939|Methanococci	183939|Methanococci	J	binds to the 23S rRNA	rpl19e	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02885	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19e
PYH3_k127_5216506_5	673860.AciM339_1115	7.098e-25	110.0	COG1717@1|root,arCOG00781@2157|Archaea,2XSZ4@28890|Euryarchaeota,3F2PV@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Belongs to the eukaryotic ribosomal protein eL32 family	rpl32e	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02912	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	HHH_5,Ribosomal_L32e
PYH3_k127_5216506_3	529709.PYCH_01540	1.221e-46	176.0	COG0097@1|root,arCOG04090@2157|Archaea,2XTIS@28890|Euryarchaeota,243D5@183968|Thermococci	183968|Thermococci	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rpl6	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
PYH3_k127_5216506_2	342949.PNA2_0366	3.268e-49	180.0	COG0096@1|root,arCOG04091@2157|Archaea,2XWMU@28890|Euryarchaeota,2440K@183968|Thermococci	183968|Thermococci	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rps8	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
PYH3_k127_5216506_6	72558.CBQ73293	4.221e-13	73.0	COG0199@1|root,KOG3506@2759|Eukaryota,3A8G0@33154|Opisthokonta,3P6KV@4751|Fungi,3V2GP@5204|Basidiomycota,3N1KM@452284|Ustilaginomycotina	4751|Fungi	J	Ribosomal protein S14p/S29e	RPS29	GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02980	ko03010,map03010	M00177	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
PYH3_k127_5216506_0	1459636.NTE_01824	2.553e-55	198.0	COG0094@1|root,arCOG04092@2157|Archaea,41SJP@651137|Thaumarchaeota	651137|Thaumarchaeota	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rpl5	-	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
PYH3_k127_5216506_1	591019.Shell_1432	2.512e-54	197.0	COG1471@1|root,arCOG04093@2157|Archaea,2XPPZ@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eS4 family	rps4e	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02987	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	RS4NT,Ribosomal_S4e,S4
PYH3_k127_5372764_14	1094980.Mpsy_1848	1.164e-06	51.0	arCOG03571@1|root,arCOG03571@2157|Archaea,2Y1FB@28890|Euryarchaeota,2NAR3@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF3795)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3795
PYH3_k127_5372764_2	1041930.Mtc_2082	5.051e-67	237.0	COG1798@1|root,arCOG04161@2157|Archaea,2XV63@28890|Euryarchaeota,2N986@224756|Methanomicrobia	224756|Methanomicrobia	J	S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF- 2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis	dphB	-	2.1.1.98	ko:K20215	-	-	R04481,R08468,R08469,R10306	RC00003,RC00190,RC01155,RC02136,RC02308	ko00000,ko01000	-	-	iAF692.Mbar_A2900	TP_methylase
PYH3_k127_5372764_12	999630.TUZN_1850	4.961e-12	69.0	COG0615@1|root,COG1849@1|root,arCOG01222@2157|Archaea,arCOG01224@2157|Archaea,2XQ8K@28889|Crenarchaeota	28889|Crenarchaeota	M	TIGRFAM cytidyltransferase-related domain	-	-	2.7.7.2	ko:K14656	ko00740,ko01100,ko01110,map00740,map01100,map01110	-	R00161	RC00002	ko00000,ko00001,ko01000	-	-	-	CTP_transf_like,DUF357
PYH3_k127_5372764_9	1220534.B655_2088	1.574e-25	111.0	COG0615@1|root,arCOG01222@2157|Archaea,2XX70@28890|Euryarchaeota,23P3H@183925|Methanobacteria	183925|Methanobacteria	F	Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme	ribL	-	2.7.7.2	ko:K14656	ko00740,ko01100,ko01110,map00740,map01100,map01110	-	R00161	RC00002	ko00000,ko00001,ko01000	-	-	-	CTP_transf_like
PYH3_k127_5372764_7	589924.Ferp_0920	1.614e-42	165.0	COG1339@1|root,arCOG01904@2157|Archaea,2XTFW@28890|Euryarchaeota,245S3@183980|Archaeoglobi	183980|Archaeoglobi	H	Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN)	ribK	-	2.7.1.161	ko:K07732	ko00740,ko01100,map00740,map01100	-	R08574	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	CTP-dep_RFKase,HTH_24
PYH3_k127_5372764_6	1196095.GAPWK_1534	1.916e-48	181.0	COG1515@1|root,COG1515@2|Bacteria,1MWRN@1224|Proteobacteria,1RRYH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA	nfi	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0016888,GO:0016893,GO:0034641,GO:0043170,GO:0043737,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360	3.1.21.7	ko:K05982	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Endonuclease_5
PYH3_k127_5372764_8	1365176.N186_04700	1.188e-30	129.0	COG2178@1|root,arCOG04318@2157|Archaea,2XQKT@28889|Crenarchaeota	28889|Crenarchaeota	J	PFAM Translin	-	-	-	ko:K07477	-	-	-	-	ko00000	-	-	-	Translin
PYH3_k127_5372764_0	694429.Pyrfu_0840	7.534e-97	327.0	COG0731@1|root,arCOG04174@2157|Archaea,2XPM3@28889|Crenarchaeota	28889|Crenarchaeota	C	Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe)	taw1	-	4.1.3.44	ko:K15449	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,Wyosine_form
PYH3_k127_5372764_4	694429.Pyrfu_0204	1.406e-57	207.0	COG0638@1|root,arCOG00970@2157|Archaea,2XQG7@28889|Crenarchaeota	28889|Crenarchaeota	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	psmB1	-	3.4.25.1	ko:K03433	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
PYH3_k127_5372764_13	573063.Metin_1282	1.055e-10	65.0	COG1531@1|root,arCOG01302@2157|Archaea,2Y015@28890|Euryarchaeota,23R8W@183939|Methanococci	183939|Methanococci	S	Belongs to the UPF0248 family	-	-	-	ko:K09715	-	-	-	-	ko00000	-	-	-	DUF504
PYH3_k127_5372764_1	410359.Pcal_2009	2.879e-80	280.0	COG0430@1|root,arCOG04125@2157|Archaea,2XPT6@28889|Crenarchaeota	28889|Crenarchaeota	J	Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP	rtcA	GO:0003674,GO:0003824,GO:0003963,GO:0009975,GO:0016874,GO:0016886,GO:0140098	6.5.1.4	ko:K01974	-	-	-	-	ko00000,ko01000	-	-	-	RTC,RTC_insert
PYH3_k127_5372764_10	309799.DICTH_1221	2.799e-25	109.0	COG0251@1|root,COG0251@2|Bacteria	2|Bacteria	J	oxidation-reduction process	-	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
PYH3_k127_5372764_11	311424.DhcVS_1238	1.815e-18	93.0	COG0350@1|root,COG0350@2|Bacteria,2G6TT@200795|Chloroflexi,34DBJ@301297|Dehalococcoidia	301297|Dehalococcoidia	L	6-O-methylguanine DNA methyltransferase, DNA binding domain	ogt	-	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1
PYH3_k127_5372764_5	933801.Ahos_0777	4.78e-51	186.0	COG1056@1|root,arCOG00972@2157|Archaea,2XQI1@28889|Crenarchaeota	28889|Crenarchaeota	F	nicotinamide-nucleotide adenylyltransferase	-	-	2.7.7.1	ko:K00952	ko00760,ko01100,map00760,map01100	-	R00137,R03005	RC00002	ko00000,ko00001,ko01000	-	-	-	CTP_transf_like
PYH3_k127_5372764_3	999630.TUZN_1856	2.259e-60	220.0	COG1912@1|root,arCOG04309@2157|Archaea,2XQIS@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM S-adenosyl-l-methionine hydroxide adenosyltransferase	-	-	-	ko:K22205	-	-	-	-	ko00000,ko01000	-	-	-	SAM_adeno_trans
PYH3_k127_5403200_3	760568.Desku_1178	1.877e-24	114.0	COG0745@1|root,COG0745@2|Bacteria,1TPWS@1239|Firmicutes,25AZ2@186801|Clostridia,2605V@186807|Peptococcaceae	186801|Clostridia	K	PFAM response regulator receiver	phoB	-	-	ko:K02483,ko:K07658,ko:K07668	ko02020,map02020	M00434,M00459	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
PYH3_k127_5403200_1	521045.Kole_1017	7.213e-46	180.0	COG0642@1|root,COG2205@2|Bacteria	521045.Kole_1017|-	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_5403200_2	304371.MCP_0374	6.085e-29	122.0	COG0680@1|root,arCOG04429@2157|Archaea,2Y0UT@28890|Euryarchaeota,2NB7J@224756|Methanomicrobia	224756|Methanomicrobia	C	Hydrogenase maturation protease	vhtD	-	-	ko:K03605	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	HycI
PYH3_k127_5403200_0	311424.DhcVS_121	2.687e-80	282.0	COG1740@1|root,COG1740@2|Bacteria,2G6Y3@200795|Chloroflexi,34D71@301297|Dehalococcoidia	301297|Dehalococcoidia	C	NiFe/NiFeSe hydrogenase small subunit C-terminal	hupS	-	1.12.99.6	ko:K06282	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFe_hyd_SSU_C,Oxidored_q6
PYH3_k127_5403200_4	138119.DSY2100	6.009e-22	96.0	COG0374@1|root,COG0374@2|Bacteria,1TQMW@1239|Firmicutes,248BB@186801|Clostridia,25ZXY@186807|Peptococcaceae	186801|Clostridia	C	Belongs to the NiFe NiFeSe hydrogenase large subunit family	-	-	1.12.99.6	ko:K06281	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
PYH3_k127_543521_3	314230.DSM3645_04550	1.498e-47	175.0	COG0542@1|root,COG0542@2|Bacteria,2IWYZ@203682|Planctomycetes	203682|Planctomycetes	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
PYH3_k127_543521_1	1379698.RBG1_1C00001G1029	9.757e-147	475.0	COG0334@1|root,COG0334@2|Bacteria,2NNRJ@2323|unclassified Bacteria	2|Bacteria	E	Belongs to the Glu Leu Phe Val dehydrogenases family	gdhA	-	1.4.1.3,1.4.1.4	ko:K00261,ko:K00262	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
PYH3_k127_543521_0	671065.MetMK1DRAFT_00013130	2.646e-155	506.0	COG1892@1|root,arCOG04435@2157|Archaea,2XQ6V@28889|Crenarchaeota	28889|Crenarchaeota	G	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle	ppcA	GO:0000287,GO:0003674,GO:0003824,GO:0004611,GO:0005488,GO:0006082,GO:0006107,GO:0008150,GO:0008152,GO:0008964,GO:0009987,GO:0015977,GO:0016829,GO:0016830,GO:0016831,GO:0019752,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0044237,GO:0044281,GO:0046872,GO:0071704	4.1.1.31	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00168,M00170,M00171,M00172,M00173,M00346,M00374	R00345	RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPcase_2
PYH3_k127_543521_2	1094980.Mpsy_1848	3.595e-48	173.0	arCOG03571@1|root,arCOG03571@2157|Archaea,2Y1FB@28890|Euryarchaeota,2NAR3@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF3795)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3795
PYH3_k127_5445334_1	521011.Mpal_1530	5.079e-64	225.0	COG5423@1|root,arCOG04361@2157|Archaea,2Y00P@28890|Euryarchaeota,2N9Y9@224756|Methanomicrobia	224756|Methanomicrobia	S	Predicted metal-binding protein (DUF2284)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2284
PYH3_k127_5445334_2	69014.TK1007	1.481e-34	148.0	COG0477@1|root,arCOG00130@2157|Archaea,2Y8EG@28890|Euryarchaeota,245MW@183968|Thermococci	183968|Thermococci	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
PYH3_k127_5445334_5	1250232.JQNJ01000001_gene3235	1.56e-15	84.0	COG5403@1|root,COG5403@2|Bacteria,4NEX0@976|Bacteroidetes,1HYHW@117743|Flavobacteriia	976|Bacteroidetes	S	PFAM Bacterial protein of	-	-	-	-	-	-	-	-	-	-	-	-	DUF937
PYH3_k127_5445334_3	289376.THEYE_A2013	6.351e-19	92.0	2E88U@1|root,332MT@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_5445334_0	768706.Desor_3837	3.365e-67	246.0	COG1600@1|root,COG1600@2|Bacteria,1V0B5@1239|Firmicutes,24FDD@186801|Clostridia,262G9@186807|Peptococcaceae	186801|Clostridia	C	TIGRFAM reductive dehalogenase	-	-	-	-	-	-	-	-	-	-	-	-	Dehalogenase,Fer4_16
PYH3_k127_5445334_4	1459636.NTE_00576	4.703e-17	85.0	arCOG09752@1|root,arCOG09752@2157|Archaea,41T9M@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_5468960_0	1365176.N186_04140	9.932e-137	449.0	COG0160@1|root,arCOG00915@2157|Archaea,2XPMC@28889|Crenarchaeota	28889|Crenarchaeota	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	gabT	-	2.6.1.19,2.6.1.22	ko:K00823,ko:K07250	ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648,R04188	RC00006,RC00062,RC00160	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
PYH3_k127_5468960_3	453591.Igni_0174	1.126e-16	83.0	COG1581@1|root,arCOG01753@2157|Archaea,2XQTM@28889|Crenarchaeota	28889|Crenarchaeota	K	Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes	albA	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K03622	-	-	-	-	ko00000	-	-	-	Alba
PYH3_k127_5468960_2	368408.Tpen_0621	2.056e-34	147.0	COG1236@1|root,arCOG00545@2157|Archaea,2XQ4Z@28889|Crenarchaeota	28889|Crenarchaeota	J	exonuclease of the beta-lactamase fold involved in RNA processing	-	-	-	ko:K07577	-	-	-	-	ko00000	-	-	-	Lactamase_B,Lactamase_B_2,Lactamase_B_3
PYH3_k127_5468960_4	1131266.ARWQ01000006_gene249	3.972e-07	54.0	COG4023@1|root,arCOG02957@2157|Archaea,41SUS@651137|Thaumarchaeota	651137|Thaumarchaeota	U	Sec61beta family	-	-	-	-	-	-	-	-	-	-	-	-	Sec61_beta
PYH3_k127_5468960_1	572547.Amico_1311	1.552e-65	237.0	COG4927@1|root,COG4927@2|Bacteria,3TB4S@508458|Synergistetes	508458|Synergistetes	S	Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase	-	-	-	ko:K19200	ko00311,ko01100,ko01130,map00311,map01100,map01130	-	-	-	ko00000,ko00001,ko01002	-	-	-	AAT
PYH3_k127_5468960_5	1104324.P186_1857	0.000838	46.0	COG0640@1|root,arCOG00731@2157|Archaea,2XR3K@28889|Crenarchaeota	28889|Crenarchaeota	K	regulatory protein, arsR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5
PYH3_k127_5520905_3	579137.Metvu_0983	1.61e-88	298.0	COG0136@1|root,arCOG00494@2157|Archaea,2XTKH@28890|Euryarchaeota,23QAD@183939|Methanococci	183939|Methanococci	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
PYH3_k127_5520905_2	573063.Metin_0016	3.606e-90	303.0	COG1830@1|root,arCOG04044@2157|Archaea,2XTBQ@28890|Euryarchaeota,23QJD@183939|Methanococci	183939|Methanococci	E	Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids	aroA'	-	2.2.1.10,4.1.2.13	ko:K16306	ko00010,ko00030,ko00051,ko00400,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00400,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001	R01068,R01070,R02568,R08568	RC00438,RC00439,RC00721,RC02301	ko00000,ko00001,ko00002,ko01000	-	-	-	DeoC
PYH3_k127_5520905_4	573063.Metin_0931	4.339e-79	276.0	COG1465@1|root,arCOG04353@2157|Archaea,2XSXD@28890|Euryarchaeota,23QQQ@183939|Methanococci	183939|Methanococci	E	Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis	aroB'	-	1.4.1.24	ko:K11646	ko00400,ko01110,ko01130,map00400,map01110,map01130	-	R08569	RC02302	ko00000,ko00001,ko01000	-	-	-	DHQS
PYH3_k127_5520905_5	255470.cbdbA430	1.782e-34	141.0	COG0710@1|root,COG0710@2|Bacteria,2GBUG@200795|Chloroflexi,34CTN@301297|Dehalococcoidia	301297|Dehalococcoidia	E	Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate	aroD	-	4.2.1.10	ko:K03785	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_I
PYH3_k127_5520905_1	203119.Cthe_3086	1.405e-116	389.0	COG0128@1|root,COG0128@2|Bacteria,1TPIH@1239|Firmicutes,2488G@186801|Clostridia,3WG99@541000|Ruminococcaceae	186801|Clostridia	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
PYH3_k127_5520905_0	720554.Clocl_1829	1.409e-130	427.0	COG0082@1|root,COG0082@2|Bacteria,1TQ40@1239|Firmicutes,24998@186801|Clostridia,3WG94@541000|Ruminococcaceae	186801|Clostridia	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	-	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
PYH3_k127_5520905_7	1121396.KB893099_gene4285	1.62e-08	59.0	COG0077@1|root,COG1605@1|root,COG0077@2|Bacteria,COG1605@2|Bacteria,1MU60@1224|Proteobacteria,42MGN@68525|delta/epsilon subdivisions,2WJET@28221|Deltaproteobacteria,2MIFU@213118|Desulfobacterales	28221|Deltaproteobacteria	E	PFAM Prephenate dehydratase	pheA	-	4.2.1.51,5.4.99.5	ko:K14170	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R00691,R01373,R01715	RC00360,RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,CM_2,PDT
PYH3_k127_5520905_6	453591.Igni_0892	8.103e-28	124.0	COG0722@1|root,COG1605@1|root,arCOG00245@2157|Archaea,arCOG02098@2157|Archaea,2XQJX@28889|Crenarchaeota	28889|Crenarchaeota	E	chorismate mutase	tyrA	-	1.3.1.12,5.4.99.5	ko:K14187	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00024,M00025	R01715,R01728	RC00125,RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	CM_2,PDH
PYH3_k127_5537964_1	368408.Tpen_0291	3.002e-175	561.0	COG0459@1|root,arCOG01257@2157|Archaea,2XPTW@28889|Crenarchaeota	28889|Crenarchaeota	O	PFAM chaperonin Cpn60 TCP-1	thsA	GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0044183,GO:0051082,GO:0061077	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
PYH3_k127_5537964_6	386456.JQKN01000013_gene3004	2.108e-102	345.0	COG0399@1|root,arCOG00118@2157|Archaea,2XTRQ@28890|Euryarchaeota,23NU5@183925|Methanobacteria	183925|Methanobacteria	E	Belongs to the DegT DnrJ EryC1 family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
PYH3_k127_5537964_21	868131.MSWAN_0689	2.719e-15	80.0	COG2164@1|root,arCOG04488@2157|Archaea,2XXU6@28890|Euryarchaeota	28890|Euryarchaeota	S	Cyclophilin-like	-	-	-	ko:K09143	-	-	-	-	ko00000	-	-	-	Cyclophil_like
PYH3_k127_5537964_22	273057.SSO0425	5.667e-05	50.0	COG4901@1|root,arCOG04327@2157|Archaea,2XRD4@28889|Crenarchaeota	28889|Crenarchaeota	J	S25 ribosomal protein	rps25e	-	-	ko:K02975	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S25
PYH3_k127_5537964_3	255470.cbdbA943	7.203e-133	432.0	COG1260@1|root,COG1260@2|Bacteria,2G5YH@200795|Chloroflexi,34CJX@301297|Dehalococcoidia	301297|Dehalococcoidia	I	Myo-inositol-1-phosphate synthase	-	-	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth
PYH3_k127_5537964_18	1459636.NTE_00653	4.891e-35	143.0	COG0284@1|root,arCOG00081@2157|Archaea,41SMN@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Orotidine 5'-phosphate decarboxylase / HUMPS family	-	-	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
PYH3_k127_5537964_7	1459636.NTE_01645	1.273e-87	301.0	COG1260@1|root,arCOG04213@2157|Archaea,41SEZ@651137|Thaumarchaeota	651137|Thaumarchaeota	I	Myo-inositol-1-phosphate synthase	-	-	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth
PYH3_k127_5537964_2	589924.Ferp_1748	4.947e-166	543.0	COG0633@1|root,COG3894@1|root,arCOG02035@2157|Archaea,arCOG02842@2157|Archaea,2XVBE@28890|Euryarchaeota,246NQ@183980|Archaeoglobi	183980|Archaeoglobi	C	Domain of unknown function (DUF4445)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
PYH3_k127_5537964_8	42256.RradSPS_0871	1.007e-79	273.0	COG1478@1|root,COG1478@2|Bacteria,2GMJ8@201174|Actinobacteria,4CQ5F@84995|Rubrobacteria	84995|Rubrobacteria	C	F420-0:Gamma-glutamyl ligase	-	-	6.3.2.31,6.3.2.34	ko:K12234	ko00680,ko01120,map00680,map01120	M00378	R09399,R09400	RC00064,RC00090,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_ligase
PYH3_k127_5537964_9	1125973.JNLC01000011_gene655	7.235e-70	249.0	COG1995@1|root,COG1995@2|Bacteria,1MXGJ@1224|Proteobacteria,2TUEU@28211|Alphaproteobacteria,3JU0Y@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	H	Pyridoxal phosphate biosynthetic protein PdxA	-	-	1.1.1.262	ko:K00097	ko00750,ko01100,map00750,map01100	M00124	R05681,R05837,R07406	RC00089,RC00675,RC01475	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxA
PYH3_k127_5537964_0	1229909.NSED_05405	3.47e-243	778.0	COG0417@1|root,arCOG15272@2157|Archaea,41S91@651137|Thaumarchaeota	651137|Thaumarchaeota	L	DNA polymerase	-	-	2.7.7.7	ko:K02319	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_pol_B,DNA_pol_B_exo1
PYH3_k127_5537964_13	720554.Clocl_2569	2.017e-50	196.0	COG0144@1|root,COG0781@1|root,COG0144@2|Bacteria,COG0781@2|Bacteria,1TP3N@1239|Firmicutes,248CS@186801|Clostridia,3WGKM@541000|Ruminococcaceae	186801|Clostridia	J	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA	sun	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,Methyltr_RsmF_N,NusB
PYH3_k127_5537964_16	304371.MCP_2644	6.482e-39	150.0	COG0437@1|root,arCOG01500@2157|Archaea,2Y7H8@28890|Euryarchaeota,2NB5B@224756|Methanomicrobia	224756|Methanomicrobia	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_6
PYH3_k127_5537964_11	523845.AQXV01000047_gene768	1.743e-53	200.0	COG2048@1|root,arCOG00338@2157|Archaea,2XTWJ@28890|Euryarchaeota,23Q7G@183939|Methanococci	183939|Methanococci	C	heterodisulfide reductase	hdrB1	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
PYH3_k127_5537964_23	304371.MCP_2641	0.0002145	49.0	arCOG13258@1|root,arCOG13258@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_5537964_14	1041930.Mtc_0296	8.913e-47	187.0	COG1009@1|root,arCOG01539@2157|Archaea,2Y85E@28890|Euryarchaeota,2NAU9@224756|Methanomicrobia	224756|Methanomicrobia	C	Proton-conducting membrane transporter	-	-	-	ko:K05565,ko:K12137	-	-	-	-	ko00000,ko01000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M
PYH3_k127_5537964_4	1041930.Mtc_0483	1.008e-120	407.0	COG0852@1|root,COG3261@1|root,arCOG01547@2157|Archaea,arCOG01551@2157|Archaea,2Y7K6@28890|Euryarchaeota,2N9MK@224756|Methanomicrobia	224756|Methanomicrobia	C	Membrane bound hydrogenase subunit	-	-	1.12.7.2	ko:K18016	-	-	R00019	-	ko00000,ko01000	-	-	-	Complex1_30kDa,Complex1_49kDa,NiFeSe_Hases
PYH3_k127_5537964_10	351160.RCIX481	4.692e-60	220.0	COG1005@1|root,arCOG01546@2157|Archaea,2XT7N@28890|Euryarchaeota,2N9XC@224756|Methanomicrobia	224756|Methanomicrobia	C	Component of the F(420)H(2) dehydrogenase (FPO complex) which is part of the energy-conserving F(420)H(2) heterodisulfide oxidoreductase system. The membrane-bound electron transfer system of the complex plays an important role in the metabolism of methylotrophic methanogens when the organisms grow on methanol or methylamines. Catalyzes the oxidation of methanophenazine to dihydromethanophenazine. It shuttles electrons from F(420)H(2), via FAD and iron-sulfur (Fe-S) centers, to methanophenazine (an electron carrier in the membrane). It couples the redox reaction to proton translocation (for every two electrons transferred, two hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	fpoH	-	1.5.98.3,1.6.5.3	ko:K00337,ko:K22163	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1,3.D.9.1	-	-	NADHdh
PYH3_k127_5537964_20	304371.MCP_2638	1.992e-24	112.0	COG1143@1|root,arCOG01543@2157|Archaea	2157|Archaea	C	Formate hydrogenlyase subunit 6 NADH ubiquinone oxidoreductase 23 kD subunit (chain I)	ehbL	-	1.1.98.4,1.12.98.1,1.17.1.9,1.8.4.10,1.8.4.8,1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K00123,ko:K00390,ko:K00441,ko:K03388,ko:K14121,ko:K22174	ko00630,ko00680,ko00920,ko01100,ko01120,ko01200,map00630,map00680,map00920,map01100,map01120,map01200	M00176,M00356,M00357,M00563,M00567	R00519,R02021,R03025,R04540,R11928,R11931,R11943,R11944	RC00007,RC00011,RC02628,RC02796,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh,Fer4,Fer4_4,Fer4_7,PAPS_reduct
PYH3_k127_5537964_15	304371.MCP_2637	1.753e-46	171.0	COG3260@1|root,arCOG01553@2157|Archaea,2Y8IV@28890|Euryarchaeota,2NAU2@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM NADH ubiquinone oxidoreductase 20 kDa subunit	-	-	1.12.7.2	ko:K18023	-	-	R00019	-	ko00000,ko01000	-	-	-	Oxidored_q6
PYH3_k127_5537964_19	309801.trd_0144	6.561e-28	117.0	COG0509@1|root,COG0509@2|Bacteria	2|Bacteria	E	glycine decarboxylation via glycine cleavage system	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
PYH3_k127_5537964_5	646529.Desaci_0969	9.004e-117	391.0	COG0277@1|root,COG0277@2|Bacteria,1TPBC@1239|Firmicutes,24A99@186801|Clostridia,262B7@186807|Peptococcaceae	186801|Clostridia	C	FAD linked oxidases, C-terminal domain	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
PYH3_k127_5537964_12	1236689.MMALV_14890	4.599e-51	196.0	COG0247@1|root,arCOG00333@2157|Archaea,2Y696@28890|Euryarchaeota,3F2WC@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	Cysteine-rich domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG
PYH3_k127_5537964_17	1239962.C943_03877	6.13e-36	154.0	COG0823@1|root,COG0823@2|Bacteria,4NEPF@976|Bacteroidetes,47NVJ@768503|Cytophagia	976|Bacteroidetes	U	WD40-like Beta Propeller Repeat	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	CarbopepD_reg_2,CarboxypepD_reg,PD40
PYH3_k127_5549229_11	565033.GACE_0493	6.941e-43	167.0	COG0463@1|root,arCOG00895@2157|Archaea,2Y7SU@28890|Euryarchaeota	28890|Euryarchaeota	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
PYH3_k127_5549229_9	696369.KI912183_gene1363	8.649e-56	205.0	2DBZQ@1|root,2ZC2Y@2|Bacteria,1V2KN@1239|Firmicutes,24G8V@186801|Clostridia,261UW@186807|Peptococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_5549229_10	1365176.N186_03345	2.532e-51	189.0	COG1976@1|root,arCOG04176@2157|Archaea,2XQJ0@28889|Crenarchaeota	28889|Crenarchaeota	J	Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex	eif6	GO:0000460,GO:0000470,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0030684,GO:0030687,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042273,GO:0043021,GO:0043023,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046483,GO:0065003,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360,GO:1902626,GO:1990904	-	ko:K03264	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009,ko03012	-	-	-	eIF-6
PYH3_k127_5549229_20	342949.PNA2_1154	5.186e-08	58.0	COG2157@1|root,arCOG04175@2157|Archaea,2Y0R1@28890|Euryarchaeota,244JC@183968|Thermococci	183968|Thermococci	J	rRNA binding	rplX	-	-	ko:K02944	ko03010,map03010	M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18A
PYH3_k127_5549229_17	386456.JQKN01000002_gene2858	5.421e-14	77.0	COG1730@1|root,arCOG01341@2157|Archaea,2Y0XZ@28890|Euryarchaeota,23P6V@183925|Methanobacteria	183925|Methanobacteria	O	Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding	pfdA	-	-	ko:K04797	-	-	-	-	ko00000,ko03110	-	-	-	Prefoldin
PYH3_k127_5549229_4	391623.TERMP_00503	8.427e-94	316.0	COG0552@1|root,arCOG01227@2157|Archaea,2XUBI@28890|Euryarchaeota,242QW@183968|Thermococci	183968|Thermococci	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
PYH3_k127_5549229_16	1343739.PAP_03140	3.364e-15	81.0	COG2451@1|root,arCOG04304@2157|Archaea,2Y0KT@28890|Euryarchaeota,244KT@183968|Thermococci	183968|Thermococci	J	Belongs to the eukaryotic ribosomal protein eL33 family	rpl35ae	-	-	ko:K02917	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35Ae
PYH3_k127_5549229_19	305700.B447_19054	1.057e-08	64.0	COG2457@1|root,COG2457@2|Bacteria,1RD0V@1224|Proteobacteria,2VS9E@28216|Betaproteobacteria,2KWHC@206389|Rhodocyclales	206389|Rhodocyclales	S	Protein of unknown function (DUF447)	-	-	-	ko:K09154	-	-	-	-	ko00000	-	-	-	DUF447
PYH3_k127_5549229_6	1041930.Mtc_1505	1.351e-79	277.0	COG1907@1|root,arCOG01026@2157|Archaea,2XUFK@28890|Euryarchaeota,2N92U@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P)	-	-	2.4.2.54	ko:K06984	ko00790,map00790	-	R10337,R11102	-	ko00000,ko00001,ko01000	-	-	-	GHMP_kinases_C
PYH3_k127_5549229_5	351160.RCIX1510	2.409e-89	314.0	COG0294@1|root,arCOG01978@2157|Archaea,2XTEW@28890|Euryarchaeota,2N967@224756|Methanomicrobia	224756|Methanomicrobia	H	PFAM dihydropteroate synthase, DHPS	-	-	-	-	-	-	-	-	-	-	-	-	DUF4346,Pterin_bind
PYH3_k127_5549229_21	1094980.Mpsy_2167	4.862e-07	60.0	arCOG06562@1|root,arCOG06562@2157|Archaea,2Y5QT@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_5549229_12	877455.Metbo_0053	6.096e-32	132.0	COG1280@1|root,arCOG01947@2157|Archaea,2XY47@28890|Euryarchaeota	28890|Euryarchaeota	E	PFAM Lysine exporter protein (LYSE YGGA)	-	-	-	-	-	-	-	-	-	-	-	-	LysE
PYH3_k127_5549229_18	1365176.N186_09185	1.633e-09	70.0	arCOG03671@1|root,arCOG10888@1|root,arCOG03671@2157|Archaea,arCOG10888@2157|Archaea	2157|Archaea	S	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	Thermopsin
PYH3_k127_5549229_0	1459636.NTE_01192	5.118e-211	670.0	COG0459@1|root,arCOG01257@2157|Archaea,41SDG@651137|Thaumarchaeota	651137|Thaumarchaeota	O	PFAM TCP-1 cpn60 chaperonin family	-	-	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
PYH3_k127_5549229_2	694429.Pyrfu_0102	1.127e-203	647.0	COG0459@1|root,arCOG01257@2157|Archaea,2XPYR@28889|Crenarchaeota	28889|Crenarchaeota	O	PFAM chaperonin Cpn60 TCP-1	thsB	GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0042802,GO:0044183,GO:0051082,GO:0061077	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
PYH3_k127_5549229_15	399550.Smar_0944	1.396e-22	98.0	COG2126@1|root,arCOG04126@2157|Archaea,2XR4H@28889|Crenarchaeota	28889|Crenarchaeota	J	Binds to the 23S rRNA	rpl37e	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02922	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L37e
PYH3_k127_5549229_14	1459636.NTE_02161	1.626e-23	101.0	COG1958@1|root,arCOG00998@2157|Archaea,41SU9@651137|Thaumarchaeota	651137|Thaumarchaeota	K	snRNP Sm proteins	-	-	-	ko:K04796	-	-	-	-	ko00000	-	-	-	LSM
PYH3_k127_5549229_13	267377.MMP0055	4.235e-24	108.0	COG2016@1|root,arCOG00985@2157|Archaea,2XX1R@28890|Euryarchaeota,23QZV@183939|Methanococci	183939|Methanococci	J	PFAM PUA domain containing protein	-	GO:0001731,GO:0002181,GO:0002183,GO:0002188,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K07575	-	-	-	-	ko00000	-	-	-	DUF1947,PUA
PYH3_k127_5549229_1	693661.Arcve_1165	2.564e-210	671.0	COG1782@1|root,arCOG00543@2157|Archaea,2XTIM@28890|Euryarchaeota,245T2@183980|Archaeoglobi	183980|Archaeoglobi	S	metal-dependent RNase, consists of a metallo-beta-lactamase domain and an RNA-binding KH domain	-	-	-	ko:K07041	-	-	-	-	ko00000	-	-	-	Beta-Casp,KH_2,KH_7,Lactamase_B,RMMBL
PYH3_k127_5549229_7	565033.GACE_1789	1.774e-60	216.0	COG0638@1|root,arCOG00970@2157|Archaea,2XUIZ@28890|Euryarchaeota,245UT@183980|Archaeoglobi	183980|Archaeoglobi	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	psmB	GO:0000502,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0019774,GO:0032991,GO:0044424,GO:0044464,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03433	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
PYH3_k127_5549229_8	1459636.NTE_02621	9.825e-60	215.0	COG1047@1|root,arCOG00980@2157|Archaea,41T0T@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Peptidyl-prolyl cis-trans	-	-	5.2.1.8	ko:K01802	-	-	-	-	ko00000,ko01000	-	-	-	FKBP_C
PYH3_k127_5549229_3	604354.TSIB_0686	1.292e-115	398.0	COG1111@1|root,arCOG00872@2157|Archaea,2XTBV@28890|Euryarchaeota,243CX@183968|Thermococci	183968|Thermococci	L	ERCC4 domain	-	-	-	ko:K10896	ko03460,map03460	M00413	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	DEAD,ERCC4,HHH_2,Helicase_C
PYH3_k127_5590682_2	1459636.NTE_01695	7.967e-125	408.0	COG1163@1|root,arCOG00358@2157|Archaea,41SAD@651137|Thaumarchaeota	651137|Thaumarchaeota	S	small GTP-binding protein	-	-	-	ko:K06944	-	-	-	-	ko00000	-	-	-	MMR_HSR1,MMR_HSR1_Xtn,TGS
PYH3_k127_5590682_11	1122921.KB898194_gene841	2.171e-18	89.0	COG1917@1|root,COG1917@2|Bacteria,1V7FN@1239|Firmicutes,4IPSM@91061|Bacilli,26XMU@186822|Paenibacillaceae	91061|Bacilli	S	conserved protein, contains double-stranded beta-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
PYH3_k127_5590682_7	755731.Clo1100_2670	3.839e-60	213.0	COG1853@1|root,COG1853@2|Bacteria,1V1EA@1239|Firmicutes,24FWS@186801|Clostridia,36FKV@31979|Clostridiaceae	186801|Clostridia	S	flavin reductase	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
PYH3_k127_5590682_6	485918.Cpin_5807	1.111e-67	234.0	COG0847@1|root,COG0847@2|Bacteria,4NJMP@976|Bacteroidetes,1IX24@117747|Sphingobacteriia	976|Bacteroidetes	L	Exonuclease RNase T and DNA polymerase III	-	-	-	-	-	-	-	-	-	-	-	-	DUF5051
PYH3_k127_5590682_9	877455.Metbo_1675	2.425e-50	188.0	arCOG01151@1|root,arCOG01151@2157|Archaea	2157|Archaea	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Metallophos_2
PYH3_k127_5590682_3	456442.Mboo_1155	3.636e-95	322.0	arCOG06074@1|root,arCOG06074@2157|Archaea,2XXIH@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_5590682_0	1220534.B655_1154	9.843e-137	458.0	COG2217@1|root,arCOG01576@2157|Archaea,2XTD8@28890|Euryarchaeota,23NU1@183925|Methanobacteria	183925|Methanobacteria	P	heavy metal-(Cd Co Hg Pb Zn)-translocating	-	-	3.6.3.3,3.6.3.5	ko:K01534	-	-	-	-	ko00000,ko01000	3.A.3.6	-	-	E1-E2_ATPase,Hydrolase
PYH3_k127_5590682_8	368407.Memar_1117	9.831e-59	211.0	COG3382@1|root,arCOG04250@2157|Archaea,2Y2KD@28890|Euryarchaeota,2NAIE@224756|Methanomicrobia	224756|Methanomicrobia	S	B3/4 domain	-	-	-	-	-	-	-	-	-	-	-	-	B3_4
PYH3_k127_5590682_1	1209989.TepiRe1_1685	1.481e-134	446.0	COG0322@1|root,COG0322@2|Bacteria,1TP4B@1239|Firmicutes,247TQ@186801|Clostridia,42ER0@68295|Thermoanaerobacterales	186801|Clostridia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
PYH3_k127_5590682_4	477974.Daud_1317	6.284e-69	251.0	COG0614@1|root,COG0614@2|Bacteria,1UNE3@1239|Firmicutes,24AKE@186801|Clostridia,261KK@186807|Peptococcaceae	186801|Clostridia	P	PFAM periplasmic binding protein	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
PYH3_k127_5590682_10	1121468.AUBR01000054_gene1450	4.468e-38	154.0	COG0109@1|root,COG0109@2|Bacteria,1TPS1@1239|Firmicutes,249CW@186801|Clostridia,42HNV@68295|Thermoanaerobacterales	186801|Clostridia	O	UbiA prenyltransferase family	ctaB	-	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
PYH3_k127_5590682_5	192952.MM_1844	1.558e-68	248.0	COG0247@1|root,arCOG00333@2157|Archaea,2Y85G@28890|Euryarchaeota,2N92Q@224756|Methanomicrobia	224756|Methanomicrobia	C	Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). HdrD may act as the catalytic subunit	hdrD	GO:0003674,GO:0003824,GO:0006091,GO:0008150,GO:0008152,GO:0009058,GO:0009061,GO:0009987,GO:0015947,GO:0015948,GO:0015975,GO:0015980,GO:0016491,GO:0016667,GO:0043446,GO:0043447,GO:0044237,GO:0044249,GO:0045333,GO:0051912,GO:0055114,GO:0071704,GO:1901576	1.8.98.1	ko:K08264	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	-	R04540	RC00011	ko00000,ko00001,ko01000	-	-	-	CCG,Fer4_8
PYH3_k127_5590682_12	765911.Thivi_2699	0.0007747	43.0	COG2181@1|root,COG2181@2|Bacteria,1QQCT@1224|Proteobacteria,1RRNM@1236|Gammaproteobacteria,1WW5S@135613|Chromatiales	135613|Chromatiales	C	nitrate reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_5603935_6	1499967.BAYZ01000171_gene5541	1.391e-103	346.0	COG2084@1|root,COG2084@2|Bacteria,2NQRW@2323|unclassified Bacteria	2|Bacteria	I	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	garR	GO:0003674,GO:0003824,GO:0005975,GO:0006082,GO:0008150,GO:0008152,GO:0008679,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0017144,GO:0019392,GO:0019394,GO:0019577,GO:0019579,GO:0019580,GO:0019752,GO:0042737,GO:0042836,GO:0042838,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046392,GO:0046395,GO:0055114,GO:0071704,GO:1901575	1.1.1.60	ko:K00042	ko00630,ko01100,map00630,map01100	-	R01745,R01747	RC00099	ko00000,ko00001,ko01000	-	-	iNRG857_1313.NRG857_15520	NAD_binding_11,NAD_binding_2
PYH3_k127_5603935_15	883078.HMPREF9695_03131	4.225e-60	224.0	COG0683@1|root,COG0683@2|Bacteria,1MUCB@1224|Proteobacteria,2TRWV@28211|Alphaproteobacteria,3JVAV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Periplasmic binding protein domain	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
PYH3_k127_5603935_7	1040989.AWZU01000008_gene3801	6.071e-74	259.0	COG0559@1|root,COG0559@2|Bacteria,1MY1E@1224|Proteobacteria,2TSIQ@28211|Alphaproteobacteria,3JR6D@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
PYH3_k127_5603935_11	426355.Mrad2831_5859	2.482e-66	238.0	COG4177@1|root,COG4177@2|Bacteria,1MWP3@1224|Proteobacteria,2VEXG@28211|Alphaproteobacteria,1JU4A@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
PYH3_k127_5603935_12	751944.HALDL1_10280	8.79e-66	233.0	COG0411@1|root,arCOG00926@2157|Archaea	751944.HALDL1_10280|-	E	COG0411 ABC-type branched-chain amino acid transport systems ATPase component	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	-
PYH3_k127_5603935_10	913865.DOT_4546	1.693e-68	239.0	COG0410@1|root,COG0410@2|Bacteria,1TPW4@1239|Firmicutes,247PN@186801|Clostridia,264ZY@186807|Peptococcaceae	186801|Clostridia	E	ABC transporter, ATP-binding protein	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
PYH3_k127_5603935_17	1519464.HY22_10255	9.469e-22	104.0	COG0671@1|root,COG0671@2|Bacteria,1FE3Y@1090|Chlorobi	1090|Chlorobi	I	phosphoesterase, PA-phosphatase related	-	-	-	-	-	-	-	-	-	-	-	-	PAP2
PYH3_k127_5603935_9	698769.JFBD01000019_gene1982	2.037e-69	242.0	COG1878@1|root,COG1878@2|Bacteria,1UZ93@1239|Firmicutes,4IRAF@91061|Bacilli	91061|Bacilli	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
PYH3_k127_5603935_19	604354.TSIB_2058	4.582e-12	76.0	arCOG10658@1|root,arCOG10658@2157|Archaea,2Y6VU@28890|Euryarchaeota,2459U@183968|Thermococci	183968|Thermococci	S	Winged helix-turn-helix DNA-binding	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_5603935_0	456442.Mboo_1047	3.852e-262	812.0	COG5310@1|root,arCOG05182@2157|Archaea,2Y2E8@28890|Euryarchaeota,2NAFG@224756|Methanomicrobia	224756|Methanomicrobia	Q	Saccharopine dehydrogenase C-terminal domain	-	-	2.5.1.44	ko:K00808	ko00960,ko01110,map00960,map01110	-	R00018	RC00053	ko00000,ko00001,ko01000	-	-	iAF692.Mbar_A2685	Sacchrp_dh_C,Sacchrp_dh_NADP
PYH3_k127_5603935_1	521011.Mpal_2447	4.851e-205	645.0	COG0019@1|root,arCOG02268@2157|Archaea,2XYK2@28890|Euryarchaeota,2N9RB@224756|Methanomicrobia	224756|Methanomicrobia	E	Pyridoxal-dependent decarboxylase, pyridoxal binding domain	-	-	4.1.1.17	ko:K01581	ko00330,ko00480,ko01100,ko01110,ko01130,map00330,map00480,map01100,map01110,map01130	M00134	R00670	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A2177	Orn_Arg_deC_N,Orn_DAP_Arg_deC
PYH3_k127_5603935_2	697303.Thewi_0375	5.958e-189	608.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,42ERP@68295|Thermoanaerobacterales	186801|Clostridia	C	Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
PYH3_k127_5603935_16	439235.Dalk_0703	2.664e-30	124.0	COG1142@1|root,COG1142@2|Bacteria,1MWE1@1224|Proteobacteria,42TYZ@68525|delta/epsilon subdivisions,2WQSE@28221|Deltaproteobacteria,2MQ1Z@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_11
PYH3_k127_5603935_21	529709.PYCH_09440	4.586e-08	59.0	COG1977@1|root,arCOG00536@2157|Archaea,2Y6GG@28890|Euryarchaeota,244HE@183968|Thermococci	183968|Thermococci	H	ThiS family	-	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
PYH3_k127_5603935_13	485913.Krac_4630	9.803e-66	235.0	COG2084@1|root,COG2084@2|Bacteria,2G8J4@200795|Chloroflexi	200795|Chloroflexi	C	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_11,NAD_binding_2
PYH3_k127_5603935_18	1459636.NTE_02727	1.449e-18	98.0	COG1630@1|root,arCOG00367@2157|Archaea	2157|Archaea	S	PFAM NurA domain	-	-	-	-	-	-	-	-	-	-	-	-	NurA
PYH3_k127_5603935_5	1459636.NTE_02728	2.677e-117	393.0	COG0433@1|root,arCOG00280@2157|Archaea	2157|Archaea	I	COG0433 Predicted ATPase	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF853,DUF87
PYH3_k127_5603935_8	439481.Aboo_0831	4.252e-70	247.0	COG0543@1|root,arCOG02199@2157|Archaea,2XSY9@28890|Euryarchaeota,3F2KR@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B	pyrK	-	-	ko:K02823	ko00240,ko01100,map00240,map01100	-	-	-	ko00000,ko00001	-	-	-	DHODB_Fe-S_bind,NAD_binding_1
PYH3_k127_5603935_20	1131266.ARWQ01000004_gene1491	7.156e-10	62.0	COG4919@1|root,arCOG04293@2157|Archaea,41SVI@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Ribosomal protein S30	-	-	-	ko:K02983	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko04121	-	-	-	Ribosomal_S30
PYH3_k127_5603935_14	1128421.JAGA01000001_gene2396	6.855e-65	236.0	COG2234@1|root,COG2234@2|Bacteria,2NP7A@2323|unclassified Bacteria	2|Bacteria	S	Peptidase M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
PYH3_k127_5603935_3	604354.TSIB_1807	3.146e-158	514.0	COG1243@1|root,arCOG01361@2157|Archaea,2XT9Z@28890|Euryarchaeota,2430Z@183968|Thermococci	183968|Thermococci	K	Radical_SAM C-terminal domain	-	-	2.3.1.48	ko:K07739	-	-	-	-	ko00000,ko01000,ko03016,ko03036	-	-	-	Acetyltransf_1,Radical_SAM,Radical_SAM_C
PYH3_k127_5603935_4	694429.Pyrfu_0958	1.479e-133	439.0	COG0252@1|root,arCOG01924@2157|Archaea,2XPTP@28889|Crenarchaeota	28889|Crenarchaeota	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate	gatD	-	6.3.5.7	ko:K09482	ko00970,ko01100,map00970,map01100	-	R03905	RC00010	ko00000,ko00001,ko01000	-	-	-	Asparaginase
PYH3_k127_5642014_4	671143.DAMO_0611	1.188e-32	141.0	COG1216@1|root,COG1216@2|Bacteria,2NRAF@2323|unclassified Bacteria	2|Bacteria	S	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	GT87
PYH3_k127_5642014_6	6500.XP_005111686.1	7.111e-05	51.0	KOG2649@1|root,KOG2649@2759|Eukaryota,38R1Y@33154|Opisthokonta,3BD7D@33208|Metazoa,3CSIH@33213|Bilateria	33208|Metazoa	S	metallocarboxypeptidase activity	CPM	GO:0003674,GO:0003824,GO:0004180,GO:0004181,GO:0004185,GO:0005575,GO:0005576,GO:0005615,GO:0005623,GO:0005886,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008236,GO:0008237,GO:0008238,GO:0009653,GO:0009986,GO:0009987,GO:0010467,GO:0016020,GO:0016485,GO:0016787,GO:0017171,GO:0019538,GO:0032502,GO:0034641,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044421,GO:0044464,GO:0048856,GO:0051604,GO:0070008,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564	3.4.17.12	ko:K01296	-	-	-	-	ko00000,ko00537,ko01000,ko01002	-	-	-	CarboxypepD_reg,Peptidase_M14
PYH3_k127_5642014_5	536233.CLO_0797	1.698e-10	70.0	COG1410@1|root,COG1410@2|Bacteria,1V7JJ@1239|Firmicutes,24AE1@186801|Clostridia,36GKK@31979|Clostridiaceae	186801|Clostridia	E	Vitamin B12 dependent methionine synthase activation	metH2	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Met_synt_B12
PYH3_k127_5642014_3	521045.Kole_0994	2.34e-34	147.0	COG3875@1|root,COG3875@2|Bacteria,2GD6T@200918|Thermotogae	200918|Thermotogae	S	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
PYH3_k127_5642014_0	224325.AF_0009	5.244e-66	236.0	COG1962@1|root,arCOG04336@2157|Archaea,2XV9A@28890|Euryarchaeota,2474P@183980|Archaeoglobi	183980|Archaeoglobi	H	Tetrahydromethanopterin S-methyltransferase MtrH subunit	-	-	2.1.1.86	ko:K00584	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00357,M00567	R04347	RC00035,RC00113,RC02892	ko00000,ko00001,ko00002,ko01000	-	-	-	MtrH
PYH3_k127_5642014_2	1268072.PSAB_12505	9.276e-62	221.0	COG1028@1|root,COG1028@2|Bacteria,1UETI@1239|Firmicutes,4HB6V@91061|Bacilli,26SBQ@186822|Paenibacillaceae	91061|Bacilli	IQ	short-chain	-	-	1.1.1.47,1.1.1.53,1.1.1.69	ko:K00034,ko:K00038,ko:K00046	ko00030,ko00140,ko01100,ko01120,ko01200,map00030,map00140,map01100,map01120,map01200	-	R01520,R01521,R04831,R04834,R04844,R04847	RC00066,RC00139,RC01219,RC01220	ko00000,ko00001,ko01000	-	-	-	adh_short_C2
PYH3_k127_5642014_1	1307436.PBF_16399	4.379e-64	227.0	COG0001@1|root,COG0001@2|Bacteria,1TRD7@1239|Firmicutes,4HA12@91061|Bacilli,1ZCDI@1386|Bacillus	91061|Bacilli	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
PYH3_k127_5646673_1	555079.Toce_0967	3.305e-27	115.0	COG0745@1|root,COG0745@2|Bacteria,1TPWS@1239|Firmicutes,25AZ2@186801|Clostridia,42JDU@68295|Thermoanaerobacterales	186801|Clostridia	K	Response regulator receiver	phoP	-	-	ko:K02483,ko:K07658,ko:K07668	ko02020,map02020	M00434,M00459	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
PYH3_k127_5646673_3	47716.JOFH01000029_gene3194	1.345e-18	98.0	COG0726@1|root,COG1215@1|root,COG0726@2|Bacteria,COG1215@2|Bacteria,2GJCE@201174|Actinobacteria	201174|Actinobacteria	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Polysacc_deac_1
PYH3_k127_5646673_4	1121007.AUML01000022_gene841	5.978e-09	63.0	28JYU@1|root,2Z9NZ@2|Bacteria,4NKTR@976|Bacteroidetes,1I0RC@117743|Flavobacteriia,2YJ0V@290174|Aquimarina	976|Bacteroidetes	P	Doubled CXXCH motif (Paired_CXXCH_1)	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,Cytochrome_C7,Paired_CXXCH_1
PYH3_k127_5646673_0	706587.Desti_3013	1.895e-89	319.0	COG0247@1|root,COG1150@1|root,COG0247@2|Bacteria,COG1150@2|Bacteria,1MUMH@1224|Proteobacteria,42N9U@68525|delta/epsilon subdivisions,2WINY@28221|Deltaproteobacteria	1224|Proteobacteria	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
PYH3_k127_5646673_2	713586.KB900536_gene1017	1.872e-20	107.0	COG2181@1|root,COG2181@2|Bacteria,1R48S@1224|Proteobacteria,1RYZ2@1236|Gammaproteobacteria,1WW9H@135613|Chromatiales	135613|Chromatiales	C	PFAM Nitrate reductase gamma subunit	-	-	-	-	-	-	-	-	-	-	-	-	Nitrate_red_gam
PYH3_k127_5674444_3	1121445.ATUZ01000011_gene673	2.328e-13	72.0	COG4231@1|root,COG4231@2|Bacteria,1N6WI@1224|Proteobacteria,42V3I@68525|delta/epsilon subdivisions,2WRKA@28221|Deltaproteobacteria,2MD6W@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM 4Fe-4S ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
PYH3_k127_5674444_0	589924.Ferp_0652	5.823e-83	287.0	COG0123@1|root,arCOG00324@2157|Archaea,2XT0B@28890|Euryarchaeota,246V5@183980|Archaeoglobi	183980|Archaeoglobi	BQ	PFAM histone deacetylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
PYH3_k127_5674444_1	224325.AF_0075	2.291e-58	217.0	COG0608@1|root,arCOG00427@2157|Archaea,2Y2ZU@28890|Euryarchaeota,246X7@183980|Archaeoglobi	183980|Archaeoglobi	L	phosphoesterase RecJ domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_5674444_2	523845.AQXV01000047_gene780	4.817e-20	96.0	COG0034@1|root,arCOG00093@2157|Archaea,2XSWJ@28890|Euryarchaeota,23Q7H@183939|Methanococci	183939|Methanococci	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_7,Pribosyltran
PYH3_k127_581187_7	386456.JQKN01000003_gene421	3.889e-84	289.0	COG0524@1|root,arCOG00014@2157|Archaea,2XU7Z@28890|Euryarchaeota,23NZS@183925|Methanobacteria	183925|Methanobacteria	G	Belongs to the carbohydrate kinase PfkB family	-	-	2.7.1.15	ko:K00852	ko00030,map00030	-	R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
PYH3_k127_581187_4	868131.MSWAN_0958	2.528e-120	393.0	COG2037@1|root,arCOG02695@2157|Archaea,2XUV2@28890|Euryarchaeota,23NJN@183925|Methanobacteria	183925|Methanobacteria	C	Formylmethanofuran-tetrahydromethanopterin formyltransferase	ftr1	-	2.3.1.101	ko:K00672	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03390	RC00197,RC00870,RC02881	ko00000,ko00001,ko00002,ko01000	-	-	-	FTR,FTR_C
PYH3_k127_581187_6	868131.MSWAN_0957	3.141e-87	300.0	COG4030@1|root,arCOG01161@2157|Archaea,2XWWH@28890|Euryarchaeota,23NXN@183925|Methanobacteria	183925|Methanobacteria	S	Protein of unknown function (DUF2961)	ehaR	-	-	ko:K14109	-	-	-	-	ko00000	-	-	-	-
PYH3_k127_581187_9	304371.MCP_2597	5.14e-70	255.0	COG0151@1|root,arCOG04415@2157|Archaea,2XTRV@28890|Euryarchaeota,2N976@224756|Methanomicrobia	224756|Methanomicrobia	F	PFAM Phosphoribosylglycinamide synthetase	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A3513	GARS_A,GARS_C,GARS_N
PYH3_k127_581187_10	1519464.HY22_13825	1.125e-68	244.0	COG0345@1|root,COG0345@2|Bacteria,1FE2A@1090|Chlorobi	1090|Chlorobi	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	-	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_oxidored,P5CR_dimer
PYH3_k127_581187_22	981383.AEWH01000041_gene3607	3.735e-06	52.0	COG0425@1|root,COG0425@2|Bacteria,1VEEC@1239|Firmicutes,4HNQT@91061|Bacilli	91061|Bacilli	O	Belongs to the sulfur carrier protein TusA family	-	-	-	-	-	-	-	-	-	-	-	-	TusA
PYH3_k127_581187_18	269799.Gmet_3453	1.543e-11	76.0	COG2391@1|root,COG2391@2|Bacteria,1MXSE@1224|Proteobacteria,42V4B@68525|delta/epsilon subdivisions	1224|Proteobacteria	S	Sulphur transport	soxT	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
PYH3_k127_581187_20	478801.Ksed_00550	1.31e-09	65.0	COG2391@1|root,COG2391@2|Bacteria,2GNSI@201174|Actinobacteria	201174|Actinobacteria	O	Belongs to the sulfur carrier protein TusA family	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp,TusA
PYH3_k127_581187_14	269797.Mbar_A0578	5.591e-23	112.0	COG0348@1|root,arCOG02772@2157|Archaea	2157|Archaea	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_5
PYH3_k127_581187_19	5911.EAR97143	3.878e-10	70.0	COG1310@1|root,KOG1555@2759|Eukaryota,3ZCWI@5878|Ciliophora	5878|Ciliophora	O	Prokaryotic homologs of the JAB domain	-	-	-	ko:K03030	ko03050,ko05169,map03050,map05169	M00341	-	-	ko00000,ko00001,ko00002,ko01002,ko03051,ko04121	-	-	-	JAB,MitMem_reg
PYH3_k127_581187_16	436308.Nmar_0544	7.518e-21	97.0	COG1184@1|root,arCOG01127@2157|Archaea,41T2Z@651137|Thaumarchaeota	651137|Thaumarchaeota	L	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
PYH3_k127_581187_2	593750.Metfor_1721	0.0	1074.0	COG1152@1|root,arCOG02428@2157|Archaea,2XTBY@28890|Euryarchaeota,2N9CY@224756|Methanomicrobia	224756|Methanomicrobia	C	Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase	cdhA	-	1.2.7.4	ko:K00192	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00422	R07157	RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_7,Fer4_9,Prismane
PYH3_k127_581187_12	351160.LRC458	2.16e-47	176.0	COG1880@1|root,arCOG04408@2157|Archaea,2XWPE@28890|Euryarchaeota,2NA4Z@224756|Methanomicrobia	224756|Methanomicrobia	C	Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. The precise role of the epsilon subunit is unclear	cdhB	-	-	ko:K00195	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00422	R07157	RC02800	ko00000,ko00001,ko00002	-	-	-	CO_dh
PYH3_k127_581187_21	435842.HMPREF0848_01167	2.655e-07	59.0	COG4708@1|root,COG4708@2|Bacteria,1V99E@1239|Firmicutes	1239|Firmicutes	S	QueT transporter	-	-	-	-	-	-	-	-	-	-	-	-	QueT
PYH3_k127_581187_15	523850.TON_0216	5.576e-22	97.0	COG2012@1|root,arCOG04258@2157|Archaea,2Y0EY@28890|Euryarchaeota,244K3@183968|Thermococci	183968|Thermococci	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoH	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03053	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb5_C
PYH3_k127_581187_1	1459636.NTE_02750	0.0	1301.0	COG0085@1|root,arCOG01762@2157|Archaea,41SF5@651137|Thaumarchaeota	651137|Thaumarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	-	-	2.7.7.6	ko:K13798	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_4,RNA_pol_Rpb2_5,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
PYH3_k127_581187_0	1459636.NTE_02749	0.0	1425.0	COG0086@1|root,arCOG04256@2157|Archaea,arCOG04257@2157|Archaea,41SB2@651137|Thaumarchaeota	651137|Thaumarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA2	-	2.7.7.6	ko:K03041	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
PYH3_k127_581187_17	415426.Hbut_1576	2.103e-19	91.0	COG1911@1|root,arCOG01752@2157|Archaea,2XR8J@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eL30 family	rpl30e	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02908	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L7Ae
PYH3_k127_581187_13	1163730.FFONT_0598	1.783e-39	151.0	COG0195@1|root,arCOG01760@2157|Archaea,2XQDA@28889|Crenarchaeota	28889|Crenarchaeota	K	Participates in transcription termination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_2,KH_5
PYH3_k127_581187_8	573063.Metin_0870	2.359e-78	271.0	COG2037@1|root,arCOG02695@2157|Archaea,2XT8E@28890|Euryarchaeota,23Q6M@183939|Methanococci	183939|Methanococci	H	Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) so as to produce 5-formyl tetrahydromethanopterin (5- formyl-H(4)MPT) and methanofuran (MFR)	ftr	-	2.3.1.101	ko:K00672	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03390	RC00197,RC00870,RC02881	ko00000,ko00001,ko00002,ko01000	-	-	-	FTR,FTR_C
PYH3_k127_581187_23	1123252.ATZF01000018_gene1635	0.0001481	53.0	COG3209@1|root,COG3209@2|Bacteria,1TR8F@1239|Firmicutes,4HWJ1@91061|Bacilli,27CIP@186824|Thermoactinomycetaceae	91061|Bacilli	M	RHS Repeat	-	-	-	-	-	-	-	-	-	-	-	-	RHS_repeat
PYH3_k127_581187_11	593117.TGAM_1921	8.721e-55	195.0	COG0048@1|root,arCOG04255@2157|Archaea,2XX4A@28890|Euryarchaeota,243D7@183968|Thermococci	183968|Thermococci	J	With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits	rps12	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
PYH3_k127_581187_3	387631.Asulf_00417	3.003e-159	510.0	COG0505@1|root,arCOG00064@2157|Archaea,2XT0H@28890|Euryarchaeota,245NS@183980|Archaeoglobi	183980|Archaeoglobi	F	Belongs to the CarA family	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
PYH3_k127_581187_5	565033.GACE_0556	6.516e-99	326.0	COG0458@1|root,arCOG01594@2157|Archaea,2XTVE@28890|Euryarchaeota,245PG@183980|Archaeoglobi	183980|Archaeoglobi	F	Belongs to the CarB family	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
PYH3_k127_5890392_5	634498.mru_0914	1.009e-106	358.0	COG0148@1|root,arCOG01169@2157|Archaea,2XSXT@28890|Euryarchaeota,23NP2@183925|Methanobacteria	183925|Methanobacteria	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
PYH3_k127_5890392_21	1365176.N186_02290	2.671e-26	109.0	COG1644@1|root,arCOG04244@2157|Archaea,2XR60@28889|Crenarchaeota	28889|Crenarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoN	GO:0000428,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0008270,GO:0030880,GO:0032991,GO:0043167,GO:0043169,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03058	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_N
PYH3_k127_5890392_17	877455.Metbo_0811	1.119e-35	140.0	COG0088@1|root,arCOG04243@2157|Archaea,2XWK0@28890|Euryarchaeota,23PIA@183925|Methanobacteria	183925|Methanobacteria	J	Belongs to the universal ribosomal protein uS9 family	rps9	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
PYH3_k127_5890392_24	673860.AciM339_1029	4.181e-21	98.0	COG0102@1|root,arCOG04242@2157|Archaea,2XWN6@28890|Euryarchaeota,3F2SC@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rpl13	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
PYH3_k127_5890392_20	323259.Mhun_2898	3.173e-29	121.0	COG1727@1|root,arCOG00780@2157|Archaea,2XZ6R@28890|Euryarchaeota,2N9UH@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the eukaryotic ribosomal protein eL18 family	rpl18e	-	-	ko:K02883	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18
PYH3_k127_5890392_9	1220534.B655_1477	3.284e-64	229.0	COG0202@1|root,arCOG04241@2157|Archaea,2XTQB@28890|Euryarchaeota,23NZ9@183925|Methanobacteria	183925|Methanobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoD	-	2.7.7.6	ko:K03047	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	Fer4,RNA_pol_A_bac,RNA_pol_L
PYH3_k127_5890392_15	1121374.KB891575_gene861	8.154e-47	172.0	COG3193@1|root,COG3193@2|Bacteria,1RB2H@1224|Proteobacteria,1S5K1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	protein possibly involved in utilization of glycolate and propanediol	-	-	-	-	-	-	-	-	-	-	-	-	Haem_degrading
PYH3_k127_5890392_18	1459636.NTE_01676	2.524e-33	141.0	arCOG08669@1|root,arCOG08669@2157|Archaea,41SEB@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_5890392_8	911008.GLAD_02810	1.698e-85	295.0	COG2220@1|root,COG2220@2|Bacteria,1N50Z@1224|Proteobacteria,1RRU3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Probably catalyzes the hydrolysis of L-ascorbate-6-P into 3-keto-L-gulonate-6-P. Is essential for L-ascorbate utilization under anaerobic conditions	ulaG	-	-	ko:K03476	ko00053,ko01100,ko01120,map00053,map01100,map01120	M00550	R07677	RC02793	ko00000,ko00001,ko00002,ko01000	-	-	iYL1228.KPN_04585	Lactamase_B_2,Lactamase_B_3
PYH3_k127_5890392_13	572478.Vdis_0027	3.699e-56	210.0	COG2262@1|root,arCOG00353@2157|Archaea,2XQ0E@28889|Crenarchaeota	28889|Crenarchaeota	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0043021,GO:0043022,GO:0044424,GO:0044464,GO:0044877	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
PYH3_k127_5890392_6	436308.Nmar_1146	5.223e-96	327.0	COG0265@1|root,arCOG02833@2157|Archaea,41S9W@651137|Thaumarchaeota	2157|Archaea	O	Trypsin-like serine protease with C-terminal PDZ domain	degP	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
PYH3_k127_5890392_2	555079.Toce_0910	2.393e-122	403.0	COG0484@1|root,COG0484@2|Bacteria,1TP00@1239|Firmicutes,248EM@186801|Clostridia,42ESV@68295|Thermoanaerobacterales	186801|Clostridia	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686,ko:K05516	-	-	-	-	ko00000,ko03029,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
PYH3_k127_5890392_0	1289135.A966_12311	7.362e-197	631.0	COG0443@1|root,COG0443@2|Bacteria,2J5I0@203691|Spirochaetes	203691|Spirochaetes	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
PYH3_k127_5890392_22	696369.KI912183_gene91	1.109e-25	114.0	COG0576@1|root,COG0576@2|Bacteria,1V6G2@1239|Firmicutes,24MQK@186801|Clostridia,26214@186807|Peptococcaceae	186801|Clostridia	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
PYH3_k127_5890392_25	222984.JNCS01000003_gene2970	2.27e-17	90.0	arCOG04522@1|root,arCOG04522@2157|Archaea,2XTU5@28890|Euryarchaeota,23U1D@183963|Halobacteria	183963|Halobacteria	O	cytochrome c biogenesis protein	dsbD	-	-	ko:K06196	-	-	-	-	ko00000,ko02000	5.A.1.2	-	-	DsbD
PYH3_k127_5890392_11	269797.Mbar_A1392	1.251e-58	217.0	COG2520@1|root,arCOG00033@2157|Archaea,2XTSI@28890|Euryarchaeota,2N925@224756|Methanomicrobia	224756|Methanomicrobia	J	Methyltransferase	-	-	2.1.1.228	ko:K15429	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	Met_10
PYH3_k127_5890392_19	224325.AF_1068	1.024e-31	129.0	COG2090@1|root,arCOG04171@2157|Archaea,2XXWX@28890|Euryarchaeota,246DZ@183980|Archaeoglobi	183980|Archaeoglobi	S	Domain of unknown function (DUF371)	-	-	-	ko:K09738	-	-	-	-	ko00000	-	-	-	DUF371
PYH3_k127_5890392_10	415426.Hbut_0632	3.811e-61	220.0	COG2518@1|root,arCOG00976@2157|Archaea,2XPYU@28889|Crenarchaeota	28889|Crenarchaeota	J	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
PYH3_k127_5890392_30	671065.MetMK1DRAFT_00033040	6.941e-05	51.0	COG5491@1|root,arCOG00452@2157|Archaea,2XQBW@28889|Crenarchaeota	28889|Crenarchaeota	D	Conserved protein implicated in secretion	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_5890392_3	694429.Pyrfu_0109	9.57e-119	391.0	COG0258@1|root,arCOG04050@2157|Archaea,2XPRH@28889|Crenarchaeota	28889|Crenarchaeota	L	Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into	fen	-	-	ko:K04799	ko03030,ko03410,ko03450,map03030,map03410,map03450	-	-	-	ko00000,ko00001,ko01000,ko03032,ko03400,ko04147	-	-	-	XPG_I,XPG_N
PYH3_k127_5890392_4	1236689.MMALV_07510	3.817e-118	395.0	COG1602@1|root,arCOG04269@2157|Archaea,2XTEQ@28890|Euryarchaeota,3F34R@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Archaeal Nre, N-terminal	nreA	-	-	-	-	-	-	-	-	-	-	-	Nre_C,Nre_N
PYH3_k127_5890392_31	446470.Snas_4283	0.0002965	53.0	COG1409@1|root,COG1409@2|Bacteria	2|Bacteria	S	acid phosphatase activity	phoA	-	-	-	-	-	-	-	-	-	-	-	Metallophos
PYH3_k127_5890392_27	1459636.NTE_02437	8.223e-11	66.0	COG1552@1|root,arCOG04049@2157|Archaea,41T87@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the eukaryotic ribosomal protein eL40 family	-	-	-	ko:K02927	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	-
PYH3_k127_5890392_1	1459636.NTE_02820	1.322e-135	444.0	COG0017@1|root,arCOG00406@2157|Archaea,41SBT@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	-	-	6.1.1.23	ko:K09759	ko00970,map00970	M00360	R03647,R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
PYH3_k127_5890392_23	386456.JQKN01000019_gene1279	1.356e-23	106.0	COG0195@1|root,arCOG01761@2157|Archaea,2XWJU@28890|Euryarchaeota	28890|Euryarchaeota	K	Transcription elongation factor	-	-	-	-	-	-	-	-	-	-	-	-	KH_5
PYH3_k127_5890392_28	1449126.JQKL01000030_gene2493	1.807e-07	55.0	COG0078@1|root,COG0078@2|Bacteria,1TPF2@1239|Firmicutes,248I5@186801|Clostridia,26827@186813|unclassified Clostridiales	186801|Clostridia	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	-	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
PYH3_k127_5890392_7	70601.3257134	5.388e-91	306.0	COG0448@1|root,arCOG00912@2157|Archaea,2XTI4@28890|Euryarchaeota,242ZT@183968|Thermococci	183968|Thermococci	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
PYH3_k127_5890392_14	593117.TGAM_0482	3.259e-49	185.0	COG1650@1|root,arCOG01616@2157|Archaea,2XUM0@28890|Euryarchaeota,243DT@183968|Thermococci	183968|Thermococci	J	D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo	dtdA	-	3.1.1.96	ko:K09716	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_deacylase
PYH3_k127_5890392_29	490899.DKAM_1106	8.203e-06	51.0	COG2443@1|root,arCOG02204@2157|Archaea,2XR4B@28889|Crenarchaeota	28889|Crenarchaeota	U	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation	-	-	-	ko:K07342	ko03060,ko04141,ko04145,ko05110,map03060,map04141,map04145,map05110	M00401	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.7,3.A.5.8,3.A.5.9	-	-	-
PYH3_k127_5890392_16	186497.PF1990	8.768e-36	142.0	COG0250@1|root,arCOG01920@2157|Archaea,2XWGQ@28890|Euryarchaeota,2441S@183968|Thermococci	183968|Thermococci	K	Transcription elongation factor Spt5	spt5	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,Spt5-NGN
PYH3_k127_5890392_12	877455.Metbo_2250	5.622e-57	202.0	COG0080@1|root,arCOG04372@2157|Archaea,2XTJN@28890|Euryarchaeota,23NZG@183925|Methanobacteria	183925|Methanobacteria	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rpl11	-	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
PYH3_k127_5890392_26	1220534.B655_0244	2.702e-17	84.0	COG0081@1|root,arCOG04289@2157|Archaea,2XTJF@28890|Euryarchaeota,23NR7@183925|Methanobacteria	183925|Methanobacteria	J	Binds directly to 23S rRNA. Probably involved in E site tRNA release	rpl1	-	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
PYH3_k127_6182331_1	374847.Kcr_0387	2.599e-21	101.0	arCOG03119@1|root,arCOG03119@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
PYH3_k127_6182331_2	1133849.O3I_024320	1.6e-18	86.0	COG3422@1|root,COG3422@2|Bacteria,2I1EE@201174|Actinobacteria,4G4W9@85025|Nocardiaceae	201174|Actinobacteria	S	Domain of unknown function (DUF1508)	-	-	-	ko:K09946	-	-	-	-	ko00000	-	-	-	DUF1508
PYH3_k127_6215164_4	768679.TTX_1341	6.194e-07	61.0	COG2244@1|root,arCOG02209@2157|Archaea,2XQQ1@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_C
PYH3_k127_6215164_1	368408.Tpen_1720	2.236e-82	283.0	COG1210@1|root,arCOG00665@2157|Archaea	2157|Archaea	M	PFAM Nucleotidyl transferase	galU	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
PYH3_k127_6215164_2	1131266.ARWQ01000003_gene1564	1.613e-69	245.0	COG0463@1|root,arCOG00894@2157|Archaea,41T1Z@651137|Thaumarchaeota	651137|Thaumarchaeota	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
PYH3_k127_6215164_0	186497.PF1357	7.349e-112	370.0	COG0451@1|root,arCOG01369@2157|Archaea,2XTTP@28890|Euryarchaeota,243ND@183968|Thermococci	28890|Euryarchaeota	M	3-beta hydroxysteroid dehydrogenase/isomerase family	-	-	4.1.1.35	ko:K08678	ko00520,ko01100,map00520,map01100	M00361	R01384	RC00508	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
PYH3_k127_6215164_3	675635.Psed_1848	7.742e-08	54.0	COG1004@1|root,COG1004@2|Bacteria,2GJQB@201174|Actinobacteria,4E15T@85010|Pseudonocardiales	201174|Actinobacteria	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	algD	-	1.1.1.132	ko:K00066	ko00051,ko00520,ko02020,map00051,map00520,map02020	-	R00880	RC00291	ko00000,ko00001,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
PYH3_k127_6216467_5	272844.PAB1102	2.151e-19	101.0	COG1361@1|root,arCOG02079@2157|Archaea,2XZCT@28890|Euryarchaeota,242X1@183968|Thermococci	183968|Thermococci	M	S-layer protein	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_6216467_1	868131.MSWAN_2252	2.03e-70	250.0	COG1131@1|root,arCOG00194@2157|Archaea,2XTJV@28890|Euryarchaeota	28890|Euryarchaeota	E	ABC-type multidrug transport system, ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
PYH3_k127_6216467_8	903818.KI912268_gene1703	2.971e-11	75.0	COG0842@1|root,COG0842@2|Bacteria	2|Bacteria	V	Transport permease protein	ybhR	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006855,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0015562,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0033554,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0071944	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
PYH3_k127_6216467_6	1216966.BAUC01000005_gene1891	2.264e-17	94.0	COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,1RPB4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	ABC-type multidrug transport system, permease component	ybhS	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006855,GO:0008150,GO:0015562,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071944	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_3
PYH3_k127_6216467_0	1286171.EAL2_808p06950	5.707e-121	400.0	COG0436@1|root,COG0436@2|Bacteria,1TP0J@1239|Firmicutes,247NQ@186801|Clostridia,25VAD@186806|Eubacteriaceae	186801|Clostridia	E	Psort location Cytoplasmic, score	aspC	-	2.6.1.1	ko:K00812,ko:K10907	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
PYH3_k127_6216467_3	1232453.BAIF02000031_gene2557	1.374e-42	170.0	COG0407@1|root,COG0407@2|Bacteria,1URPV@1239|Firmicutes,24XIW@186801|Clostridia	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
PYH3_k127_6216467_2	368408.Tpen_1553	4.237e-62	223.0	COG3839@1|root,arCOG00175@2157|Archaea,2XPVK@28889|Crenarchaeota	28889|Crenarchaeota	E	PFAM ABC transporter related	-	-	3.6.3.30	ko:K02010	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10	-	-	ABC_tran
PYH3_k127_6216467_4	667014.Thein_0487	1.035e-29	128.0	COG0555@1|root,COG0555@2|Bacteria,2GI4G@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02018	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	BPD_transp_1
PYH3_k127_6216467_7	399550.Smar_1578	7.603e-14	75.0	arCOG03119@1|root,arCOG03119@2157|Archaea,2XQUD@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
PYH3_k127_6234705_5	313628.LNTAR_21023	5.489e-16	85.0	COG0138@1|root,COG0138@2|Bacteria	2|Bacteria	F	bifunctional purine biosynthesis protein purh	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
PYH3_k127_6234705_1	237368.SCABRO_02780	1.219e-56	204.0	COG0138@1|root,COG0138@2|Bacteria,2IXB5@203682|Planctomycetes	203682|Planctomycetes	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
PYH3_k127_6234705_0	1276221.SDIMI_v3c07870	1.605e-113	383.0	COG0516@1|root,COG0516@2|Bacteria,3WT11@544448|Tenericutes	544448|Tenericutes	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
PYH3_k127_6234705_4	247490.KSU1_C1282	9.038e-26	119.0	28K4S@1|root,30U3F@2|Bacteria,2J1UP@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_6234705_2	797114.C475_03309	2.418e-52	193.0	COG1136@1|root,arCOG00922@2157|Archaea,2XUH3@28890|Euryarchaeota,23T7A@183963|Halobacteria	183963|Halobacteria	E	ABC-type antimicrobial peptide transport system, ATPase component	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
PYH3_k127_6234705_3	589865.DaAHT2_0922	1.913e-50	196.0	COG4591@1|root,COG4591@2|Bacteria,1QVSQ@1224|Proteobacteria,43BSZ@68525|delta/epsilon subdivisions,2WME9@28221|Deltaproteobacteria,2MMBK@213118|Desulfobacterales	28221|Deltaproteobacteria	M	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
PYH3_k127_6234705_6	456442.Mboo_2163	1.07e-06	57.0	arCOG06510@1|root,arCOG06510@2157|Archaea	2157|Archaea	S	Domain of unknown function (DUF4389)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4389
PYH3_k127_6285217_6	246969.TAM4_2011	7.046e-07	63.0	COG5617@1|root,arCOG07110@2157|Archaea,2Y38Y@28890|Euryarchaeota,24337@183968|Thermococci	183968|Thermococci	S	6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	PTPS_related
PYH3_k127_6285217_3	1459636.NTE_00782	2.575e-51	202.0	COG1708@1|root,arCOG01186@1|root,arCOG01186@2157|Archaea,arCOG07292@2157|Archaea	2157|Archaea	G	Nucleotidyltransferase domain	-	-	-	ko:K07076	-	-	-	-	ko00000	-	-	-	APH,NTP_transf_2
PYH3_k127_6285217_4	246969.TAM4_704	4.237e-39	154.0	COG0560@1|root,arCOG01158@2157|Archaea,2XT0C@28890|Euryarchaeota,242US@183968|Thermococci	183968|Thermococci	E	phosphoserine phosphatase	-	-	3.1.3.3	ko:K01079	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R00582	RC00017	ko00000,ko00001,ko00002,ko01000,ko01009	-	-	-	HAD
PYH3_k127_6285217_1	1459636.NTE_03013	1.333e-64	230.0	COG2519@1|root,arCOG00978@2157|Archaea,41SEF@651137|Thaumarchaeota	651137|Thaumarchaeota	Q	tRNA methyltransferase complex GCD14 subunit	-	-	2.1.1.219,2.1.1.220	ko:K07442	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	GCD14
PYH3_k127_6285217_0	1209989.TepiRe1_0442	1.811e-69	246.0	COG2084@1|root,COG2084@2|Bacteria,1TR4F@1239|Firmicutes,249YG@186801|Clostridia,42JCA@68295|Thermoanaerobacterales	186801|Clostridia	C	COGs COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenase	-	-	1.1.1.291,1.1.1.31,1.1.1.60	ko:K00020,ko:K00042,ko:K19647	ko00280,ko00630,ko00760,ko01100,ko01120,map00280,map00630,map00760,map01100,map01120	-	R01745,R01747,R05066,R07985	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
PYH3_k127_6285217_5	666510.ASAC_0035	3.906e-07	55.0	arCOG05464@1|root,arCOG05464@2157|Archaea,2XR3S@28889|Crenarchaeota	28889|Crenarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_6285217_2	1195236.CTER_0541	6.184e-60	212.0	COG3808@1|root,COG3808@2|Bacteria,1TNZI@1239|Firmicutes,248KS@186801|Clostridia,3WHVU@541000|Ruminococcaceae	186801|Clostridia	C	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
PYH3_k127_6387137_3	768706.Desor_4420	1.05e-108	368.0	COG5598@1|root,COG5598@2|Bacteria,1TR30@1239|Firmicutes,24CK1@186801|Clostridia	186801|Clostridia	H	PFAM Trimethylamine methyltransferase (MTTB)	-	-	2.1.1.250	ko:K14083	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09124,R10016	RC00035,RC00732,RC01144,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	MTTB
PYH3_k127_6387137_8	1089553.Tph_c27670	2.353e-59	212.0	COG5012@1|root,COG5012@2|Bacteria,1V1P0@1239|Firmicutes,24G08@186801|Clostridia,42FJI@68295|Thermoanaerobacterales	186801|Clostridia	S	Methionine synthase B12-binding module cap domain protein	-	-	2.1.1.13	ko:K00548,ko:K14084	ko00270,ko00450,ko00670,ko00680,ko01100,ko01110,ko01120,ko01200,ko01230,map00270,map00450,map00670,map00680,map01100,map01110,map01120,map01200,map01230	M00017,M00563	R00946,R09124,R09365	RC00035,RC00113,RC00732,RC01241,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2
PYH3_k127_6387137_0	1265505.ATUG01000002_gene2462	1.025e-111	369.0	COG2355@1|root,COG2355@2|Bacteria,1MWEW@1224|Proteobacteria,42NXB@68525|delta/epsilon subdivisions,2WMBF@28221|Deltaproteobacteria,2MPC0@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Membrane dipeptidase (Peptidase family M19)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M19
PYH3_k127_6387137_7	589924.Ferp_1610	6.166e-83	289.0	COG2768@1|root,arCOG02448@2157|Archaea,2XW30@28890|Euryarchaeota,246RQ@183980|Archaeoglobi	183980|Archaeoglobi	C	Domain of unknown function (DUF362)	-	-	-	ko:K07138	-	-	-	-	ko00000	-	-	-	DUF362,Fer4
PYH3_k127_6387137_6	323259.Mhun_1311	3.264e-84	284.0	COG1592@1|root,arCOG01097@2157|Archaea,2XWSA@28890|Euryarchaeota,2NBII@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM Rubrerythrin	rbr-1	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
PYH3_k127_6387137_11	693661.Arcve_0342	8.89e-49	180.0	COG4739@1|root,arCOG04483@2157|Archaea,2XYZT@28890|Euryarchaeota,24725@183980|Archaeoglobi	183980|Archaeoglobi	S	Uncharacterized protein containing a ferredoxin domain (DUF2148)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2148,FeS
PYH3_k127_6387137_2	335543.Sfum_2466	5.438e-109	368.0	COG1042@1|root,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,42KZW@68525|delta/epsilon subdivisions,2WIQB@28221|Deltaproteobacteria,2MR9S@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	CoA binding domain	-	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
PYH3_k127_6387137_1	1009370.ALO_11729	2.554e-109	367.0	COG2768@1|root,COG2768@2|Bacteria,1TPRV@1239|Firmicutes,4H3EN@909932|Negativicutes	909932|Negativicutes	C	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
PYH3_k127_6387137_13	903814.ELI_3312	2.304e-35	145.0	COG1146@1|root,COG2006@1|root,COG1146@2|Bacteria,COG2006@2|Bacteria,1TRX2@1239|Firmicutes,249GX@186801|Clostridia,25VVJ@186806|Eubacteriaceae	186801|Clostridia	C	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362,Fer4,Fer4_10,Fer4_7
PYH3_k127_6387137_14	565033.GACE_1311	1.58e-34	143.0	COG2057@1|root,arCOG05316@2157|Archaea,2XW2C@28890|Euryarchaeota,246AI@183980|Archaeoglobi	183980|Archaeoglobi	I	Coenzyme A transferase	-	-	2.8.3.12	ko:K01040	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
PYH3_k127_6387137_9	224325.AF_1199	4.561e-55	203.0	COG1788@1|root,arCOG01987@2157|Archaea,2XVRA@28890|Euryarchaeota,246WP@183980|Archaeoglobi	183980|Archaeoglobi	I	Coenzyme A transferase	-	-	2.8.3.12	ko:K01039	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
PYH3_k127_6387137_4	867903.ThesuDRAFT_00399	2.862e-107	355.0	COG0492@1|root,COG0492@2|Bacteria,1TNZS@1239|Firmicutes,2491M@186801|Clostridia,3WCH9@538999|Clostridiales incertae sedis	186801|Clostridia	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	trxB	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
PYH3_k127_6387137_5	192952.MM_2455	2.577e-95	323.0	COG1131@1|root,arCOG00194@2157|Archaea,2XUK9@28890|Euryarchaeota,2N95K@224756|Methanomicrobia	224756|Methanomicrobia	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
PYH3_k127_6387137_10	456442.Mboo_0613	1.85e-51	198.0	COG0842@1|root,arCOG01467@2157|Archaea,2Y87M@28890|Euryarchaeota,2NBP0@224756|Methanomicrobia	224756|Methanomicrobia	V	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
PYH3_k127_6387137_12	604354.TSIB_0031	1.328e-47	177.0	COG2890@1|root,arCOG00109@2157|Archaea,2XWJZ@28890|Euryarchaeota,242YQ@183968|Thermococci	183968|Thermococci	Q	Pfam:Methyltransf_26	-	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS
PYH3_k127_6414887_6	342949.PNA2_1866	3.689e-111	369.0	COG0015@1|root,arCOG01747@2157|Archaea,2XUQ5@28890|Euryarchaeota,24385@183968|Thermococci	183968|Thermococci	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	purB	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
PYH3_k127_6414887_9	1220534.B655_1361	3.427e-53	205.0	COG0367@1|root,arCOG00071@2157|Archaea,2XSYP@28890|Euryarchaeota,23NSW@183925|Methanobacteria	183925|Methanobacteria	E	TIGRFAM asparagine synthase (glutamine-hydrolyzing)	asnB	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
PYH3_k127_6414887_4	1054217.TALC_01492	1.421e-121	400.0	COG0309@1|root,arCOG00636@2157|Archaea,2XTAH@28890|Euryarchaeota,241W7@183967|Thermoplasmata	183967|Thermoplasmata	O	AIR synthase related protein, C-terminal domain	-	-	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
PYH3_k127_6414887_3	1236689.MMALV_11490	6.232e-125	409.0	COG0409@1|root,arCOG04428@2157|Archaea,2XTJA@28890|Euryarchaeota,3F2F1@33867|unclassified Euryarchaeota	28890|Euryarchaeota	O	TIGRFAM hydrogenase expression formation protein HypD	hypD	-	-	ko:K04654	-	-	-	-	ko00000	-	-	-	HypD
PYH3_k127_6414887_12	868131.MSWAN_0444	1.147e-26	113.0	COG0375@1|root,arCOG04426@2157|Archaea,2XZI2@28890|Euryarchaeota,23P60@183925|Methanobacteria	183925|Methanobacteria	S	Probably plays a role in a hydrogenase nickel cofactor insertion step	hypA	-	-	ko:K04651	-	-	-	-	ko00000,ko03110	-	-	-	HypA
PYH3_k127_6414887_8	579137.Metvu_0183	1.364e-64	228.0	COG0378@1|root,arCOG01231@2157|Archaea,2XUJS@28890|Euryarchaeota,23QIT@183939|Methanococci	183939|Methanococci	O	TIGRFAM Hydrogenase accessory protein HypB	-	-	-	ko:K04652	-	-	-	-	ko00000,ko03110	-	-	-	cobW
PYH3_k127_6414887_13	1236689.MMALV_14480	9.675e-21	93.0	COG0298@1|root,arCOG04427@2157|Archaea,2Y0AJ@28890|Euryarchaeota,3F2UW@33867|unclassified Euryarchaeota	28890|Euryarchaeota	O	TIGRFAM hydrogenase assembly chaperone hypC hupF	hypC	-	-	ko:K04653	-	-	-	-	ko00000	-	-	-	HupF_HypC
PYH3_k127_6414887_1	868131.MSWAN_2243	1.36e-213	687.0	COG0068@1|root,arCOG01187@2157|Archaea,2XTHZ@28890|Euryarchaeota,23NPD@183925|Methanobacteria	183925|Methanobacteria	O	Belongs to the carbamoyltransferase HypF family	hypF	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
PYH3_k127_6414887_14	634498.mru_0698	4.788e-15	83.0	COG1390@1|root,arCOG00869@2157|Archaea,2Y782@28890|Euryarchaeota,23P3B@183925|Methanobacteria	183925|Methanobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpE	-	-	ko:K02121	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_E
PYH3_k127_6414887_11	589924.Ferp_2309	2.54e-32	144.0	COG1269@1|root,arCOG04138@2157|Archaea,2XTQP@28890|Euryarchaeota,245R0@183980|Archaeoglobi	183980|Archaeoglobi	C	Belongs to the V-ATPase 116 kDa subunit family	-	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
PYH3_k127_6414887_17	1499967.BAYZ01000009_gene5287	4.012e-06	53.0	COG0636@1|root,COG0636@2|Bacteria	2|Bacteria	C	ATP hydrolysis coupled proton transport	atpE	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02110,ko:K02124	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157,M00159	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1,3.A.2.2,3.A.2.3	-	-	ATP-synt_C
PYH3_k127_6414887_15	339860.Msp_1137	2.468e-13	82.0	COG1527@1|root,arCOG02459@2157|Archaea,2XTK5@28890|Euryarchaeota,23NMG@183925|Methanobacteria	183925|Methanobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	-	-	ko:K02119	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_AC39
PYH3_k127_6414887_16	342949.PNA2_0834	3.25e-06	59.0	COG1527@1|root,arCOG02459@2157|Archaea,2XTK5@28890|Euryarchaeota,2432C@183968|Thermococci	183968|Thermococci	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	-	-	ko:K02119	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_AC39
PYH3_k127_6414887_7	255470.cbdbA1054	4.962e-78	269.0	COG0070@1|root,COG0070@2|Bacteria,2GAN8@200795|Chloroflexi,34CUP@301297|Dehalococcoidia	301297|Dehalococcoidia	E	GXGXG motif	-	-	-	-	-	-	-	-	-	-	-	-	GXGXG
PYH3_k127_6414887_0	387631.Asulf_00011	6.221e-229	720.0	COG0069@1|root,arCOG00619@2157|Archaea,2Y7H6@28890|Euryarchaeota,245Q2@183980|Archaeoglobi	183980|Archaeoglobi	E	Belongs to the glutamate synthase family	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Glu_syn_central,Glu_synthase
PYH3_k127_6414887_2	552811.Dehly_0989	5.112e-153	491.0	COG0067@1|root,COG0067@2|Bacteria,2GAS0@200795|Chloroflexi,34D79@301297|Dehalococcoidia	301297|Dehalococcoidia	E	Glutamine amidotransferases class-II	-	-	-	-	-	-	-	-	-	-	-	-	GATase_2
PYH3_k127_6414887_5	552811.Dehly_0990	6.353e-113	378.0	COG1251@1|root,COG1251@2|Bacteria,2G6YZ@200795|Chloroflexi,34D0M@301297|Dehalococcoidia	301297|Dehalococcoidia	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2
PYH3_k127_6414887_10	552811.Dehly_0992	2.383e-52	191.0	COG1142@1|root,COG1142@2|Bacteria,2GAMK@200795|Chloroflexi,34CSF@301297|Dehalococcoidia	301297|Dehalococcoidia	C	4Fe-4S dicluster domain	-	-	-	ko:K00196	ko00633,ko00680,ko00720,ko01120,ko01200,map00633,map00680,map00720,map01120,map01200	-	R07157,R08034	RC00250,RC02800	ko00000,ko00001	-	-	-	Fer4,Fer4_11
PYH3_k127_6522056_2	591019.Shell_1353	3.806e-134	441.0	COG0403@1|root,arCOG00077@2157|Archaea,2XQ1W@28889|Crenarchaeota	28889|Crenarchaeota	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPA	-	1.4.4.2	ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
PYH3_k127_6522056_0	272844.PAB1172	2.758e-198	629.0	COG1003@1|root,arCOG00076@2157|Archaea,2XT3V@28890|Euryarchaeota,242MV@183968|Thermococci	183968|Thermococci	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPB	-	1.4.4.2	ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
PYH3_k127_6522056_1	1229909.NSED_09600	7.19e-172	549.0	COG0112@1|root,arCOG00070@2157|Archaea,41S7U@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
PYH3_k127_6522056_4	374847.Kcr_0835	1.35e-54	202.0	COG1478@1|root,arCOG02714@2157|Archaea	2157|Archaea	E	Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives	cofE	GO:0003674,GO:0003824,GO:0016874,GO:0016879,GO:0016881,GO:0052618	6.3.2.31,6.3.2.34	ko:K12234	ko00680,ko01120,map00680,map01120	M00378	R09399,R09400	RC00064,RC00090,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_ligase
PYH3_k127_6522056_7	445972.ANACOL_02308	1.563e-11	74.0	COG1082@1|root,COG1082@2|Bacteria,1UUVZ@1239|Firmicutes,24E3D@186801|Clostridia	186801|Clostridia	L	COG COG1082 Sugar phosphate isomerases epimerases	-	-	-	ko:K10709	-	-	-	-	ko00000	-	-	-	AP_endonuc_2
PYH3_k127_6522056_3	340099.Teth39_0287	3.257e-128	421.0	COG0156@1|root,COG0156@2|Bacteria,1TPUX@1239|Firmicutes,2491D@186801|Clostridia,42FUG@68295|Thermoanaerobacterales	186801|Clostridia	H	PFAM Aminotransferase class I and II	kbl	GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008710,GO:0008890,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.3.1.29,2.3.1.47	ko:K00639,ko:K00652	ko00260,ko00780,ko01100,map00260,map00780,map01100	M00123,M00573,M00577	R00371,R03210,R10124	RC00004,RC00039,RC00394,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
PYH3_k127_6522056_6	1408428.JNJP01000024_gene3773	3.695e-24	111.0	COG2159@1|root,COG2159@2|Bacteria,1PWNH@1224|Proteobacteria,43EMG@68525|delta/epsilon subdivisions,2X128@28221|Deltaproteobacteria,2ME1X@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
PYH3_k127_6522056_5	345219.Bcoa_2272	2.553e-36	141.0	COG0509@1|root,COG0509@2|Bacteria,1V6WV@1239|Firmicutes,4HIMA@91061|Bacilli,1ZGG0@1386|Bacillus	91061|Bacilli	E	Is also involved in protein lipoylation via its role as an octanoyl lipoyl carrier protein intermediate	gcvH	GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
PYH3_k127_6522056_8	404380.Gbem_0395	7.634e-11	64.0	COG0404@1|root,COG0404@2|Bacteria,1MV96@1224|Proteobacteria,42QM6@68525|delta/epsilon subdivisions,2WJ8G@28221|Deltaproteobacteria,43TN6@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	PFAM glycine cleavage T protein (aminomethyl transferase)	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
PYH3_k127_6691227_13	1459636.NTE_01695	2.882e-46	170.0	COG1163@1|root,arCOG00358@2157|Archaea,41SAD@651137|Thaumarchaeota	651137|Thaumarchaeota	S	small GTP-binding protein	-	-	-	ko:K06944	-	-	-	-	ko00000	-	-	-	MMR_HSR1,MMR_HSR1_Xtn,TGS
PYH3_k127_6691227_15	880073.Calab_2491	2.77e-39	160.0	COG0407@1|root,COG0407@2|Bacteria,2NRD5@2323|unclassified Bacteria	2|Bacteria	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
PYH3_k127_6691227_11	1121422.AUMW01000010_gene1062	2.304e-59	212.0	COG2110@1|root,COG2110@2|Bacteria,1TPCU@1239|Firmicutes,24ARG@186801|Clostridia,261T9@186807|Peptococcaceae	186801|Clostridia	S	PFAM Appr-1-p processing	ymdB	-	-	-	-	-	-	-	-	-	-	-	Macro
PYH3_k127_6691227_16	579137.Metvu_0459	3.265e-35	142.0	COG0705@1|root,arCOG01770@2157|Archaea,2Y895@28890|Euryarchaeota,23RKY@183939|Methanococci	183939|Methanococci	E	PFAM Rhomboid family protein	-	-	-	ko:K07059	-	-	-	-	ko00000	-	-	-	Rhomboid
PYH3_k127_6691227_6	1123288.SOV_1c09030	6.269e-86	294.0	COG1237@1|root,COG1237@2|Bacteria,1VDQ3@1239|Firmicutes	1239|Firmicutes	S	Beta-lactamase superfamily domain	dhpS	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
PYH3_k127_6691227_9	1125863.JAFN01000001_gene3045	1.784e-68	241.0	COG1024@1|root,COG1024@2|Bacteria,1MUJ7@1224|Proteobacteria,42PEX@68525|delta/epsilon subdivisions,2WK6S@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
PYH3_k127_6691227_12	767817.Desgi_3267	7.796e-48	174.0	COG1149@1|root,COG1149@2|Bacteria,1VUEG@1239|Firmicutes,2503A@186801|Clostridia,267CF@186807|Peptococcaceae	186801|Clostridia	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_21,Fer4_6
PYH3_k127_6691227_3	926550.CLDAP_20810	1.339e-127	417.0	COG0585@1|root,COG0585@2|Bacteria	2|Bacteria	J	pseudouridine synthase activity	truD	GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0016070,GO:0016853,GO:0016866,GO:0034641,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360	5.4.99.27	ko:K06176	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruD
PYH3_k127_6691227_8	868131.MSWAN_0032	9.365e-69	246.0	COG2768@1|root,arCOG02448@2157|Archaea,2XW30@28890|Euryarchaeota,23PAX@183925|Methanobacteria	183925|Methanobacteria	C	Domain of unknown function (DUF362)	-	-	-	ko:K07138	-	-	-	-	ko00000	-	-	-	DUF362,Fer4
PYH3_k127_6691227_5	1156937.MFUM_310051	1.395e-110	368.0	COG1064@1|root,COG1064@2|Bacteria,46VKT@74201|Verrucomicrobia,37H8I@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	C	Zinc-binding dehydrogenase	-	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
PYH3_k127_6691227_20	1449126.JQKL01000006_gene737	1.82e-20	103.0	COG2006@1|root,COG2006@2|Bacteria,1TRYQ@1239|Firmicutes,24966@186801|Clostridia,26BAW@186813|unclassified Clostridiales	186801|Clostridia	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
PYH3_k127_6691227_1	237368.SCABRO_00111	4.489e-276	865.0	COG1331@1|root,COG1331@2|Bacteria,2IX0N@203682|Planctomycetes	203682|Planctomycetes	O	COG1331 Highly conserved protein containing a thioredoxin domain	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	DsbC,GlcNAc_2-epim,Thioredox_DsbH
PYH3_k127_6691227_19	1365176.N186_09310	1.223e-20	93.0	COG1872@1|root,arCOG04058@2157|Archaea	2157|Archaea	S	Belongs to the UPF0235 family	-	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
PYH3_k127_6691227_7	1379698.RBG1_1C00001G1876	2.568e-83	287.0	COG0301@1|root,COG0301@2|Bacteria,2NP8U@2323|unclassified Bacteria	2|Bacteria	H	Thiamine biosynthesis protein (ThiI)	-	-	-	-	-	-	-	-	-	-	-	-	DUF814,ThiI,tRNA_Me_trans
PYH3_k127_6691227_14	880073.Calab_3225	4.873e-41	162.0	COG0170@1|root,COG1836@1|root,COG0170@2|Bacteria,COG1836@2|Bacteria,2NPNT@2323|unclassified Bacteria	2|Bacteria	I	Integral membrane protein DUF92	-	GO:0005575,GO:0016020	2.7.1.182,2.7.7.41	ko:K00981,ko:K18678	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799,R10659	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF92
PYH3_k127_6691227_17	1343739.PAP_01610	4.618e-35	143.0	COG0170@1|root,arCOG01880@2157|Archaea,2XY6G@28890|Euryarchaeota	28890|Euryarchaeota	I	PFAM phosphatidate cytidylyltransferase	-	-	2.7.1.182	ko:K18678	-	-	R10659	RC00002,RC00017	ko00000,ko01000	-	-	-	-
PYH3_k127_6691227_18	304371.MCP_2678	3.845e-33	139.0	arCOG04609@1|root,arCOG04609@2157|Archaea,2XVS1@28890|Euryarchaeota,2N9XU@224756|Methanomicrobia	224756|Methanomicrobia	S	Domain of unknown function (DUF4349)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4349
PYH3_k127_6691227_2	1131462.DCF50_p1758	5.771e-199	641.0	COG2217@1|root,COG2217@2|Bacteria,1TP5S@1239|Firmicutes,247MW@186801|Clostridia,2608V@186807|Peptococcaceae	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
PYH3_k127_6691227_21	57918.XP_004298734.1	5.931e-09	61.0	COG2217@1|root,KOG0207@2759|Eukaryota,37HKS@33090|Viridiplantae,3G7MY@35493|Streptophyta,4JJ7G@91835|fabids	35493|Streptophyta	P	Copper-transporting ATPase	-	GO:0003674,GO:0003824,GO:0005215,GO:0005388,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006816,GO:0006950,GO:0008150,GO:0008324,GO:0009636,GO:0010035,GO:0010038,GO:0010273,GO:0015075,GO:0015085,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042623,GO:0042625,GO:0042626,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043492,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046688,GO:0046873,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0061687,GO:0070588,GO:0070838,GO:0071944,GO:0072511,GO:0090662,GO:0097501,GO:0098655,GO:0098660,GO:0098662,GO:0098754,GO:0099131,GO:0099132,GO:1990169	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
PYH3_k127_6691227_0	56780.SYN_02589	0.0	1657.0	COG0458@1|root,COG0458@2|Bacteria,1NPMZ@1224|Proteobacteria,42NF3@68525|delta/epsilon subdivisions,2WM4C@28221|Deltaproteobacteria,2MQ8X@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	Carbamoyl-phosphate synthetase large chain, oligomerisation	-	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_0661	CPSase_L_D2,CPSase_L_D3,MGS
PYH3_k127_6691227_4	706587.Desti_2694	2.265e-125	410.0	COG0057@1|root,COG0057@2|Bacteria,1N2N1@1224|Proteobacteria	1224|Proteobacteria	G	Glyceraldehyde-3-phosphate dehydrogenase	-	-	1.2.1.59	ko:K00150	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166	R01061,R01063	RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_N,Gp_dh_C
PYH3_k127_6691227_25	255470.cbdbA1147	4.691e-06	55.0	2A4HG@1|root,30T3R@2|Bacteria,2GAZU@200795|Chloroflexi,34DNN@301297|Dehalococcoidia	301297|Dehalococcoidia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_6691227_22	1237149.C900_02118	6.667e-09	63.0	COG1266@1|root,COG1266@2|Bacteria,4NVAP@976|Bacteroidetes,47SVF@768503|Cytophagia	976|Bacteroidetes	S	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
PYH3_k127_6691227_24	1349820.M707_09050	1.34e-07	60.0	COG0716@1|root,COG0716@2|Bacteria	2|Bacteria	C	FMN binding	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_1,Flavodoxin_3,Flavodoxin_5
PYH3_k127_6691227_10	644282.Deba_0147	1.162e-61	226.0	COG2515@1|root,COG2515@2|Bacteria,1MVYF@1224|Proteobacteria,42PWI@68525|delta/epsilon subdivisions,2WPU4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Pyridoxal-phosphate dependent enzyme	-	-	4.4.1.15	ko:K05396	ko00270,map00270	-	R01874	RC00382	ko00000,ko00001,ko01000	-	-	-	PALP
PYH3_k127_6692802_2	192952.MM_0420	7.619e-59	214.0	COG0674@1|root,arCOG01606@2157|Archaea,2XSUJ@28890|Euryarchaeota,2N91I@224756|Methanomicrobia	224756|Methanomicrobia	C	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR,POR_N
PYH3_k127_6692802_7	1121342.AUCO01000010_gene2337	5.649e-09	68.0	COG5650@1|root,COG5650@2|Bacteria,1TQVD@1239|Firmicutes,25CFN@186801|Clostridia,36DSE@31979|Clostridiaceae	186801|Clostridia	S	integral membrane protein	-	-	2.4.1.109	ko:K00728	ko00514,ko00515,ko01100,map00514,map00515,map01100	-	R04072,R07620,R11399	RC00005,RC00059,RC00397	ko00000,ko00001,ko01000,ko01003	-	GT39	-	GT87,PMT_2
PYH3_k127_6692802_1	251221.35211855	2.426e-93	322.0	COG1032@1|root,COG1032@2|Bacteria,1G3ZK@1117|Cyanobacteria	1117|Cyanobacteria	C	TIGRFAM Hopanoid biosynthesis associated radical SAM protein HpnJ	-	-	1.21.98.3	ko:K04034	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R06268,R06269,R06270	RC00741,RC01491,RC01492	ko00000,ko00001,ko01000	-	-	-	B12-binding,Radical_SAM
PYH3_k127_6692802_6	1536774.H70357_19720	8.313e-10	66.0	COG0346@1|root,COG0346@2|Bacteria,1V235@1239|Firmicutes,4HHQP@91061|Bacilli,26WSR@186822|Paenibacillaceae	91061|Bacilli	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
PYH3_k127_6692802_5	592015.HMPREF1705_01721	1.795e-10	66.0	28XQZ@1|root,2ZJMK@2|Bacteria,3TCGY@508458|Synergistetes	508458|Synergistetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_6692802_4	1303518.CCALI_02450	6.676e-33	143.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
PYH3_k127_6692802_3	311424.DhcVS_766	1.101e-42	164.0	COG1905@1|root,COG1905@2|Bacteria,2G6Q5@200795|Chloroflexi,34CKC@301297|Dehalococcoidia	301297|Dehalococcoidia	C	Thioredoxin-like [2Fe-2S] ferredoxin	-	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
PYH3_k127_6692802_0	269799.Gmet_2080	6.066e-191	606.0	COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,42N6N@68525|delta/epsilon subdivisions,2WJ1W@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Respiratory-chain NADH dehydrogenase domain 51 kDa subunit	bamH	-	1.6.5.3	ko:K00124,ko:K00335,ko:K05587	ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200	M00144	R00519,R11945	RC00061,RC02796	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iAF987.Gmet_2080	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
PYH3_k127_6693963_6	436308.Nmar_1555	1.506e-55	200.0	COG0131@1|root,arCOG04398@2157|Archaea,41SGY@651137|Thaumarchaeota	651137|Thaumarchaeota	E	imidazoleglycerol-phosphate dehydratase	hisB	-	4.2.1.19	ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03457	RC00932	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPD
PYH3_k127_6693963_4	1121422.AUMW01000001_gene2344	1.059e-59	213.0	COG0118@1|root,COG0118@2|Bacteria,1TQT0@1239|Firmicutes,248SH@186801|Clostridia,260M0@186807|Peptococcaceae	186801|Clostridia	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	-	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
PYH3_k127_6693963_5	243232.MJ_1532	1.166e-58	212.0	COG0106@1|root,arCOG00618@2157|Archaea,2XSUF@28890|Euryarchaeota,23QJK@183939|Methanococci	183939|Methanococci	E	TIGRFAM Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase	hisA	GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
PYH3_k127_6693963_2	579137.Metvu_0824	2.972e-102	340.0	COG0107@1|root,arCOG00617@2157|Archaea,2XU22@28890|Euryarchaeota,23Q2Q@183939|Methanococci	183939|Methanococci	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
PYH3_k127_6693963_7	717605.Theco_3504	1.993e-47	179.0	COG0139@1|root,COG0140@1|root,COG0139@2|Bacteria,COG0140@2|Bacteria,1UYNA@1239|Firmicutes,4HA9R@91061|Bacilli,26S4F@186822|Paenibacillaceae	91061|Bacilli	E	Histidine biosynthesis bifunctional protein HisIE	hisI	-	3.5.4.19,3.6.1.31	ko:K01496,ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035,R04037	RC00002,RC01055	ko00000,ko00001,ko00002,ko01000	-	-	iSB619.SA_RS14110,iYO844.BSU34860	PRA-CH,PRA-PH
PYH3_k127_6693963_1	1047013.AQSP01000140_gene2452	1.411e-163	522.0	COG0473@1|root,COG0473@2|Bacteria,2NNUM@2323|unclassified Bacteria	2|Bacteria	CE	Isocitrate/isopropylmalate dehydrogenase	dlpA	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh,MoCF_biosynth,RraA-like
PYH3_k127_6693963_0	1459636.NTE_02176	6.887e-189	602.0	COG0119@1|root,arCOG02092@2157|Archaea,41SBX@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Belongs to the alpha-IPM synthase homocitrate synthase family	-	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
PYH3_k127_6693963_8	511062.GU3_06935	1.373e-08	58.0	COG0473@1|root,COG0473@2|Bacteria,1QU2H@1224|Proteobacteria,1T1N6@1236|Gammaproteobacteria,1Y53V@135624|Aeromonadales	135624|Aeromonadales	C	Isocitrate/isopropylmalate dehydrogenase	-	-	1.1.1.41	ko:K00030	ko00020,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010	R00709	RC00114	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
PYH3_k127_6693963_3	289376.THEYE_A0114	8.006e-67	229.0	COG0473@1|root,COG0473@2|Bacteria,3J0JQ@40117|Nitrospirae	40117|Nitrospirae	C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
PYH3_k127_6809137_0	868595.Desca_2530	5.666e-239	748.0	COG0178@1|root,COG0178@2|Bacteria,1TPIJ@1239|Firmicutes,2485F@186801|Clostridia,260NC@186807|Peptococcaceae	186801|Clostridia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
PYH3_k127_6809137_7	1250278.JQNQ01000001_gene2559	1.099e-13	82.0	COG3408@1|root,COG3408@2|Bacteria,4NGZM@976|Bacteroidetes,1I02Y@117743|Flavobacteriia	976|Bacteroidetes	G	Alkaline and neutral invertase	-	-	-	-	-	-	-	-	-	-	-	-	GDE_C,Glyco_hydro_100,S6PP
PYH3_k127_6809137_2	304371.MCP_1164	1.784e-136	443.0	COG0535@1|root,arCOG00938@2157|Archaea,2XUDB@28890|Euryarchaeota,2NAB8@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM
PYH3_k127_6809137_3	1094980.Mpsy_1152	1.48e-122	403.0	COG0263@1|root,arCOG00864@2157|Archaea,2XV1I@28890|Euryarchaeota,2NAAX@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate	proB	-	2.7.2.11	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	M00015	R00239	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,PUA
PYH3_k127_6809137_1	519442.Huta_1371	1.788e-153	496.0	COG0014@1|root,arCOG01253@2157|Archaea,2XU44@28890|Euryarchaeota,23U59@183963|Halobacteria	183963|Halobacteria	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate	proA	-	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
PYH3_k127_6809137_6	568768.CM001975_gene1537	3.653e-22	106.0	COG0778@1|root,COG0778@2|Bacteria,1NIJ8@1224|Proteobacteria,1RMRT@1236|Gammaproteobacteria,2JBYT@204037|Dickeya	1236|Gammaproteobacteria	C	Nitroreductase family	nfsA	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0010181,GO:0016491,GO:0016651,GO:0016657,GO:0032553,GO:0034567,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050662,GO:0055114,GO:0097159,GO:0097367,GO:1901265,GO:1901363	1.5.1.38	ko:K10678,ko:K19285	ko00633,ko00740,ko01100,ko01120,map00633,map00740,map01100,map01120	-	R05706,R08014,R08017,R08042	RC00126,RC00250	ko00000,ko00001,ko01000	-	-	-	Nitroreductase
PYH3_k127_6809137_4	671065.MetMK1DRAFT_00021910	2.181e-38	153.0	COG1011@1|root,arCOG02291@2157|Archaea	2157|Archaea	S	hydrolase (HAD superfamily)	-	-	3.8.1.2	ko:K01560,ko:K07025	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05287	RC00697	ko00000,ko00001,ko01000	-	-	-	HAD_2
PYH3_k127_6809137_5	797209.ZOD2009_13406	1.057e-26	110.0	COG0006@1|root,arCOG01000@2157|Archaea,2XTI9@28890|Euryarchaeota,23TKY@183963|Halobacteria	183963|Halobacteria	E	Belongs to the peptidase M24B family	pepQ1	-	-	-	-	-	-	-	-	-	-	-	Creatinase_N,Peptidase_M24
PYH3_k127_6842022_3	237368.SCABRO_01833	5.54e-29	130.0	COG0463@1|root,COG0463@2|Bacteria	2|Bacteria	M	Glycosyl transferase, family 2	-	-	2.7.8.20	ko:K01002,ko:K20534	ko01100,map01100	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.2.1.9	GT2	-	GT87,Glycos_transf_2
PYH3_k127_6842022_4	1382359.JIAL01000001_gene418	5.146e-21	98.0	COG0454@1|root,COG0456@2|Bacteria,3Y5G1@57723|Acidobacteria,2JJWU@204432|Acidobacteriia	204432|Acidobacteriia	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
PYH3_k127_6842022_1	546271.Selsp_1453	2.68e-58	209.0	COG0652@1|root,COG0652@2|Bacteria,1TRHW@1239|Firmicutes,4H408@909932|Negativicutes	909932|Negativicutes	M	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	ppiB	-	-	-	-	-	-	-	-	-	-	-	Pro_isomerase
PYH3_k127_6842022_8	529709.PYCH_06310	1.297e-07	59.0	COG0440@1|root,arCOG00811@2157|Archaea,2XY7D@28890|Euryarchaeota,2449W@183968|Thermococci	183968|Thermococci	E	ACT domain	-	-	-	-	-	-	-	-	-	-	-	-	ACT
PYH3_k127_6842022_2	1365176.N186_02695	1.463e-54	214.0	COG1269@1|root,arCOG04138@2157|Archaea,2XQ7V@28889|Crenarchaeota	28889|Crenarchaeota	C	Belongs to the V-ATPase 116 kDa subunit family	atpI	GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005515,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006873,GO:0006885,GO:0007035,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019725,GO:0019829,GO:0019899,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030003,GO:0030004,GO:0030641,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042592,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044769,GO:0045851,GO:0046034,GO:0046390,GO:0046483,GO:0046961,GO:0048878,GO:0050801,GO:0051117,GO:0051179,GO:0051234,GO:0051452,GO:0051453,GO:0055067,GO:0055080,GO:0055082,GO:0055085,GO:0055086,GO:0065007,GO:0065008,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098771,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
PYH3_k127_6842022_7	1499967.BAYZ01000009_gene5287	6.365e-13	74.0	COG0636@1|root,COG0636@2|Bacteria	2|Bacteria	C	ATP hydrolysis coupled proton transport	atpE	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02110,ko:K02124	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157,M00159	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1,3.A.2.2,3.A.2.3	-	-	ATP-synt_C
PYH3_k127_6842022_5	373903.Hore_19450	2.809e-19	100.0	COG1527@1|root,COG1527@2|Bacteria,1U1QE@1239|Firmicutes,24A4E@186801|Clostridia	186801|Clostridia	C	Archaeal vacuolar-type H -ATPase subunit C	ntpC	-	-	ko:K02119	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_AC39
PYH3_k127_6842022_6	760011.Spico_0755	1.808e-14	81.0	COG1394@1|root,COG1394@2|Bacteria,2J5V1@203691|Spirochaetes	203691|Spirochaetes	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpD	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
PYH3_k127_6842022_0	374847.Kcr_1301	2.068e-182	578.0	COG1156@1|root,arCOG00865@2157|Archaea	2157|Archaea	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit	atpB	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
PYH3_k127_6856245_5	374847.Kcr_1470	8.839e-46	181.0	COG1819@1|root,arCOG01393@2157|Archaea	2157|Archaea	CG	Glycosyltransferase 28 domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tran_28_C,Glyco_trans_1_3
PYH3_k127_6856245_4	246969.TAM4_1600	7.04e-66	231.0	COG2078@1|root,arCOG01336@2157|Archaea,2XUAP@28890|Euryarchaeota,242T1@183968|Thermococci	183968|Thermococci	S	AMMECR1	-	-	-	ko:K09141	-	-	-	-	ko00000	-	-	-	AMMECR1
PYH3_k127_6856245_6	415426.Hbut_1150	1.004e-36	143.0	COG1656@1|root,arCOG04290@2157|Archaea,2XQD5@28889|Crenarchaeota	28889|Crenarchaeota	S	Mut7-C RNAse domain	-	-	-	ko:K09122	-	-	-	-	ko00000	-	-	-	Mut7-C
PYH3_k127_6856245_2	1220534.B655_0054	4.1e-84	295.0	COG0044@1|root,arCOG00689@2157|Archaea,2XTQU@28890|Euryarchaeota,23NQR@183925|Methanobacteria	183925|Methanobacteria	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	pyrC	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
PYH3_k127_6856245_7	1459636.NTE_03282	3.081e-31	130.0	COG0517@1|root,arCOG00606@2157|Archaea	2157|Archaea	I	CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
PYH3_k127_6856245_0	386456.JQKN01000001_gene2034	6.374e-109	377.0	COG1293@1|root,arCOG01695@2157|Archaea,2XTMF@28890|Euryarchaeota,23NMS@183925|Methanobacteria	183925|Methanobacteria	K	Domain of unknown function (DUF814)	-	-	-	-	-	-	-	-	-	-	-	-	DUF814,FbpA
PYH3_k127_6856245_8	195522.BD01_1581	5.854e-06	55.0	arCOG05775@1|root,arCOG05775@2157|Archaea,2XXSH@28890|Euryarchaeota,244BF@183968|Thermococci	183968|Thermococci	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_6856245_1	1343739.PAP_10275	1.941e-102	343.0	COG0468@1|root,arCOG00415@2157|Archaea,2XT80@28890|Euryarchaeota,242UY@183968|Thermococci	183968|Thermococci	L	Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules	radA	GO:0000150,GO:0000217,GO:0000400,GO:0000724,GO:0000725,GO:0000730,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003697,GO:0003824,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006312,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022607,GO:0033554,GO:0034622,GO:0034641,GO:0042148,GO:0042623,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0045003,GO:0046483,GO:0050896,GO:0051716,GO:0065003,GO:0065004,GO:0071704,GO:0071824,GO:0071840,GO:0090304,GO:0090735,GO:0097159,GO:0140097,GO:1901360,GO:1901363	-	ko:K04483	-	-	-	-	ko00000,ko03400	-	-	-	HHH_5,Intein_splicing,LAGLIDADG_3,Rad51
PYH3_k127_6856245_3	1196322.A370_03522	2.911e-66	234.0	COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,247PV@186801|Clostridia,36EGR@31979|Clostridiaceae	186801|Clostridia	IQ	reductase	fabG	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
PYH3_k127_7006731_1	439481.Aboo_0302	1.887e-175	569.0	COG4231@1|root,arCOG01609@2157|Archaea,2XUNR@28890|Euryarchaeota,3F2HQ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	iorA	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,Fer4_7,POR_N,TPP_enzyme_C
PYH3_k127_7006731_11	1054217.TALC_00961	1.083e-43	166.0	COG1014@1|root,arCOG01602@2157|Archaea,2XXK2@28890|Euryarchaeota,242GA@183967|Thermoplasmata	183967|Thermoplasmata	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	-	-	1.2.7.8	ko:K00180	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR
PYH3_k127_7006731_9	323259.Mhun_0326	4.268e-68	249.0	COG0683@1|root,arCOG01020@2157|Archaea,2XVWV@28890|Euryarchaeota	2157|Archaea	E	ABC-type branched-chain amino acid transport systems, periplasmic component	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
PYH3_k127_7006731_5	593750.Metfor_1699	1.945e-93	314.0	COG0559@1|root,arCOG01270@2157|Archaea,2XUY9@28890|Euryarchaeota	28890|Euryarchaeota	E	COG0559 Branched-chain amino acid ABC-type transport system, permease components	livH5	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
PYH3_k127_7006731_6	593750.Metfor_1700	1.969e-77	269.0	COG4177@1|root,arCOG01274@2157|Archaea,2XVR5@28890|Euryarchaeota	28890|Euryarchaeota	E	Branched-chain amino acid transport system permease component	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
PYH3_k127_7006731_8	1499967.BAYZ01000159_gene528	2.64e-72	250.0	COG0410@1|root,COG0410@2|Bacteria,2NNXF@2323|unclassified Bacteria	2|Bacteria	E	ABC transporter	livF	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
PYH3_k127_7006731_10	323259.Mhun_0330	1.815e-65	231.0	COG0411@1|root,arCOG00925@2157|Archaea,2XU75@28890|Euryarchaeota	28890|Euryarchaeota	E	COG0411 ABC-type branched-chain amino acid transport systems ATPase component	livG-6	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
PYH3_k127_7006731_0	1094980.Mpsy_2737	9.255e-186	589.0	COG1541@1|root,arCOG02620@2157|Archaea,2XU3A@28890|Euryarchaeota,2N95A@224756|Methanomicrobia	224756|Methanomicrobia	H	AMP-binding enzyme C-terminal domain	paaK-2	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
PYH3_k127_7006731_15	935948.KE386494_gene175	4.296e-16	83.0	COG4747@1|root,COG4747@2|Bacteria,1V7U2@1239|Firmicutes,24JE5@186801|Clostridia,42GI5@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM amino acid-binding ACT domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ACT
PYH3_k127_7006731_7	309799.DICTH_1155	2.91e-75	260.0	COG1045@1|root,COG1045@2|Bacteria	2|Bacteria	E	serine acetyltransferase	cysE	GO:0000096,GO:0000097,GO:0000098,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009001,GO:0009056,GO:0009058,GO:0009063,GO:0009066,GO:0009068,GO:0009069,GO:0009070,GO:0009087,GO:0009987,GO:0016053,GO:0016054,GO:0016407,GO:0016412,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044272,GO:0044273,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	iSB619.SA_RS02865,iYO844.BSU00930	Hexapep,SATase_N
PYH3_k127_7006731_12	1094980.Mpsy_0709	1.374e-29	128.0	COG0673@1|root,arCOG01622@2157|Archaea,2XTZY@28890|Euryarchaeota,2N9E7@224756|Methanomicrobia	224756|Methanomicrobia	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	1.1.1.374	ko:K18855	-	-	-	-	ko00000,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
PYH3_k127_7006731_16	1232437.KL661967_gene5056	4.248e-14	79.0	COG1763@1|root,COG1763@2|Bacteria,1RD3Q@1224|Proteobacteria,42RZK@68525|delta/epsilon subdivisions,2WQ3C@28221|Deltaproteobacteria,2MKAT@213118|Desulfobacterales	28221|Deltaproteobacteria	H	molybdopterin-guanine dinucleotide biosynthesis protein	mobB	-	2.7.7.77	ko:K03753,ko:K13818	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	MobB,NTP_transf_3
PYH3_k127_7006731_2	1365176.N186_02690	3.278e-147	482.0	COG1042@1|root,arCOG01340@2157|Archaea,2XPR9@28889|Crenarchaeota	28889|Crenarchaeota	C	PFAM CoA-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding_2,Succ_CoA_lig
PYH3_k127_7006731_14	387631.Asulf_00452	1.564e-17	84.0	COG0826@1|root,arCOG03202@2157|Archaea	2157|Archaea	O	PFAM peptidase U32	-	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_U32
PYH3_k127_7006731_4	374847.Kcr_1603	1.595e-132	438.0	COG0016@1|root,arCOG00410@2157|Archaea	2157|Archaea	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily	pheS	GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2d
PYH3_k127_7006731_3	272844.PAB2427	9.585e-138	457.0	COG0072@1|root,arCOG00412@2157|Archaea,2XTD5@28890|Euryarchaeota,242YE@183968|Thermococci	183968|Thermococci	J	Phenylalanyl-tRNA synthetase beta subunit	pheT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,tRNA-synt_2d
PYH3_k127_7006731_13	552811.Dehly_1590	2.956e-24	106.0	COG1720@1|root,COG1720@2|Bacteria,2G799@200795|Chloroflexi,34DAJ@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Uncharacterised protein family UPF0066	-	-	-	-	-	-	-	-	-	-	-	-	UPF0066
PYH3_k127_7060349_1	469383.Cwoe_5897	5.622e-09	67.0	COG5542@1|root,COG5542@2|Bacteria,2HNS4@201174|Actinobacteria,4CPZM@84995|Rubrobacteria	84995|Rubrobacteria	S	Mannosyltransferase (PIG-V)	-	-	-	-	-	-	-	-	-	-	-	-	Mannosyl_trans2
PYH3_k127_7060349_0	342949.PNA2_1115	9.965e-57	212.0	COG0297@1|root,COG0438@1|root,arCOG01403@2157|Archaea,arCOG01420@2157|Archaea,2XVAJ@28890|Euryarchaeota,243HN@183968|Thermococci	183968|Thermococci	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
PYH3_k127_7109988_2	857293.CAAU_0436	3.703e-68	241.0	COG0601@1|root,COG0601@2|Bacteria,1TP1S@1239|Firmicutes,247IP@186801|Clostridia,36F10@31979|Clostridiaceae	186801|Clostridia	P	PFAM binding-protein-dependent transport systems inner membrane component	appB	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
PYH3_k127_7109988_3	926561.KB900620_gene2923	1.128e-65	234.0	COG1173@1|root,COG1173@2|Bacteria,1TP4R@1239|Firmicutes,2489T@186801|Clostridia,3WBHC@53433|Halanaerobiales	186801|Clostridia	EP	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02034,ko:K15582	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1,OppC_N
PYH3_k127_7109988_1	292459.STH2824	1.037e-119	392.0	COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,247NN@186801|Clostridia	186801|Clostridia	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031,ko:K02032,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
PYH3_k127_7109988_0	1209989.TepiRe1_2045	1.079e-131	426.0	COG4608@1|root,COG4608@2|Bacteria,1V36J@1239|Firmicutes,24C3R@186801|Clostridia,42F38@68295|Thermoanaerobacterales	186801|Clostridia	P	TIGRFAM oligopeptide dipeptide ABC transporter, ATPase subunit	-	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
PYH3_k127_7228983_2	693661.Arcve_0901	1.2e-74	256.0	COG0778@1|root,arCOG00288@2157|Archaea,2XXW2@28890|Euryarchaeota	28890|Euryarchaeota	C	Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
PYH3_k127_7228983_4	694429.Pyrfu_1064	3.715e-44	177.0	COG0683@1|root,arCOG01020@2157|Archaea,2XQM1@28889|Crenarchaeota	28889|Crenarchaeota	E	Periplasmic binding protein	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
PYH3_k127_7228983_6	693661.Arcve_0901	2.309e-13	71.0	COG0778@1|root,arCOG00288@2157|Archaea,2XXW2@28890|Euryarchaeota	28890|Euryarchaeota	C	Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
PYH3_k127_7228983_1	330214.NIDE3111	3.636e-93	317.0	COG0179@1|root,COG0179@2|Bacteria,3J1AP@40117|Nitrospirae	40117|Nitrospirae	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
PYH3_k127_7228983_0	1499967.BAYZ01000119_gene3222	9.127e-170	543.0	COG0174@1|root,COG0174@2|Bacteria,2NNY0@2323|unclassified Bacteria	2|Bacteria	E	glutamine synthetase	glnA2	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016787,GO:0016810,GO:0016811,GO:0044464,GO:0050001,GO:0071944	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
PYH3_k127_7228983_3	1123229.AUBC01000010_gene3368	4.324e-68	245.0	COG1748@1|root,COG1748@2|Bacteria,1QXB2@1224|Proteobacteria	1224|Proteobacteria	E	Saccharopine dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_7228983_5	604354.TSIB_1199	3.841e-20	94.0	COG1581@1|root,arCOG01753@2157|Archaea,2XZH4@28890|Euryarchaeota,244BC@183968|Thermococci	183968|Thermococci	K	Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes	albA	-	-	ko:K03622	-	-	-	-	ko00000	-	-	-	Alba
PYH3_k127_7368458_4	1041930.Mtc_0352	6.937e-40	162.0	COG0463@1|root,arCOG01385@2157|Archaea,2Y0V7@28890|Euryarchaeota,2NB3P@224756|Methanomicrobia	224756|Methanomicrobia	M	N-terminal domain of galactosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
PYH3_k127_7368458_1	368408.Tpen_0461	6.377e-86	291.0	COG0130@1|root,arCOG00987@2157|Archaea,2XPWX@28889|Crenarchaeota	28889|Crenarchaeota	J	Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs	truB	GO:0000154,GO:0000495,GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016072,GO:0016073,GO:0016074,GO:0016556,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0031120,GO:0031123,GO:0031126,GO:0033979,GO:0034470,GO:0034641,GO:0034660,GO:0034964,GO:0040031,GO:0042254,GO:0043144,GO:0043170,GO:0043412,GO:0043628,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360,GO:1990481	5.4.99.25	ko:K03177,ko:K11131	ko03008,map03008	M00425	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03016,ko03032	-	-	-	DKCLD,PUA,TruB_C_2,TruB_N
PYH3_k127_7368458_8	490899.DKAM_1147	2.129e-19	90.0	COG0130@1|root,arCOG00987@2157|Archaea,2XPWX@28889|Crenarchaeota	28889|Crenarchaeota	J	Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs	truB	GO:0000154,GO:0000495,GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016072,GO:0016073,GO:0016074,GO:0016556,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0031120,GO:0031123,GO:0031126,GO:0033979,GO:0034470,GO:0034641,GO:0034660,GO:0034964,GO:0040031,GO:0042254,GO:0043144,GO:0043170,GO:0043412,GO:0043628,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360,GO:1990481	5.4.99.25	ko:K03177,ko:K11131	ko03008,map03008	M00425	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03016,ko03032	-	-	-	DKCLD,PUA,TruB_C_2,TruB_N
PYH3_k127_7368458_6	273057.SSO5763	2.981e-25	108.0	COG2163@1|root,arCOG04167@2157|Archaea,2XQT9@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eL14 family	rpl14e	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02875	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14e
PYH3_k127_7368458_5	694429.Pyrfu_1686	2.744e-38	150.0	COG1102@1|root,arCOG01037@2157|Archaea,2XQ8J@28889|Crenarchaeota	28889|Crenarchaeota	F	Belongs to the cytidylate kinase family. Type 2 subfamily	cmk	-	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin2
PYH3_k127_7368458_10	1459636.NTE_02792	6.615e-05	51.0	COG1422@1|root,arCOG02673@2157|Archaea,41SNR@651137|Thaumarchaeota	651137|Thaumarchaeota	U	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF106
PYH3_k127_7368458_0	1365176.N186_02080	8.698e-121	404.0	COG5253@1|root,arCOG04169@2157|Archaea,2XPYG@28889|Crenarchaeota	28889|Crenarchaeota	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	Plug_translocon,SecY
PYH3_k127_7368458_7	985053.VMUT_1762	6.916e-25	108.0	COG0200@1|root,arCOG00779@2157|Archaea,2XQH0@28889|Crenarchaeota	28889|Crenarchaeota	J	Binds to the 23S rRNA	rpl15	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
PYH3_k127_7368458_9	673860.AciM339_1119	2.713e-15	82.0	COG1841@1|root,arCOG04086@2157|Archaea,2XWGP@28890|Euryarchaeota,3F2NM@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Ribosomal protein L30p/L7e	rpl30	GO:0000463,GO:0000470,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
PYH3_k127_7368458_2	768679.TTX_1410	3.731e-69	241.0	COG0098@1|root,arCOG04087@2157|Archaea,2XPK9@28889|Crenarchaeota	28889|Crenarchaeota	J	With S4 and S12 plays an important role in translational accuracy	rps5	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
PYH3_k127_7368458_3	604354.TSIB_0308	1.134e-58	210.0	COG0256@1|root,arCOG04088@2157|Archaea,2XTWT@28890|Euryarchaeota,243VI@183968|Thermococci	183968|Thermococci	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rpl18	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18_c,Ribosomal_L5e
PYH3_k127_7368458_11	419665.Maeo_1402	0.0002496	43.0	COG2147@1|root,arCOG04089@2157|Archaea,2XWU1@28890|Euryarchaeota,23QT2@183939|Methanococci	183939|Methanococci	J	binds to the 23S rRNA	rpl19e	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02885	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19e
PYH3_k127_7388369_25	589924.Ferp_1087	0.0002065	44.0	COG0247@1|root,arCOG00333@2157|Archaea,2Y3NQ@28890|Euryarchaeota,24747@183980|Archaeoglobi	183980|Archaeoglobi	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
PYH3_k127_7388369_21	1232410.KI421424_gene1760	1.789e-09	66.0	COG2010@1|root,COG2010@2|Bacteria,1QYFZ@1224|Proteobacteria,43CC3@68525|delta/epsilon subdivisions,2WQTQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_7388369_16	314230.DSM3645_11122	1.055e-23	104.0	COG1917@1|root,COG1917@2|Bacteria,2J1N5@203682|Planctomycetes	203682|Planctomycetes	G	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_7388369_0	1459636.NTE_00800	6.037e-268	842.0	COG0480@1|root,arCOG01559@2157|Archaea,41S9B@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K03234	ko04152,ko04921,map04152,map04921	-	-	-	ko00000,ko00001,ko03012,ko04147	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
PYH3_k127_7388369_10	529709.PYCH_00170	6.718e-57	205.0	COG2102@1|root,arCOG00035@2157|Archaea,2XTNJ@28890|Euryarchaeota,242TE@183968|Thermococci	183968|Thermococci	S	Diphthamide synthase	-	-	6.3.1.14	ko:K06927	-	-	R03613	RC00358	ko00000,ko01000,ko03012	-	-	-	Diphthami_syn_2
PYH3_k127_7388369_8	399550.Smar_0385	1.836e-63	223.0	COG0794@1|root,arCOG00068@2157|Archaea,2XQ7R@28889|Crenarchaeota	28889|Crenarchaeota	M	PFAM sugar isomerase (SIS)	hxlB	-	5.3.1.27	ko:K08094	ko00030,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00680,map01100,map01120,map01200,map01230	M00345,M00580	R05339,R09780	RC00377	ko00000,ko00001,ko00002,ko01000	-	-	-	SIS
PYH3_k127_7388369_13	666510.ASAC_0386	1.771e-33	139.0	COG1948@1|root,arCOG04206@2157|Archaea,2XQJU@28889|Crenarchaeota	28889|Crenarchaeota	L	ERCC4 domain protein	-	-	-	ko:K10848	ko03420,ko03460,map03420,map03460	-	-	-	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	ERCC4,HHH_5
PYH3_k127_7388369_12	368408.Tpen_0712	3.027e-44	170.0	COG0619@1|root,arCOG02250@2157|Archaea	2157|Archaea	P	PFAM Cobalt transport protein	-	-	-	ko:K16785	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	CbiQ
PYH3_k127_7388369_3	368408.Tpen_0713	1.267e-80	276.0	COG1122@1|root,arCOG00202@2157|Archaea	2157|Archaea	P	ABC-type cobalt transport system ATPase component	cbiO	-	-	ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran
PYH3_k127_7388369_7	485916.Dtox_1967	1.533e-70	248.0	COG0488@1|root,COG0488@2|Bacteria,1UI2R@1239|Firmicutes,25EBF@186801|Clostridia,267CI@186807|Peptococcaceae	186801|Clostridia	S	PFAM ABC transporter related	-	-	-	ko:K16785,ko:K16786,ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran
PYH3_k127_7388369_14	591019.Shell_1603	1.565e-31	136.0	COG0618@1|root,arCOG01565@2157|Archaea,2XQUB@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM phosphoesterase, RecJ domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DHH,DHHA1
PYH3_k127_7388369_17	1459636.NTE_01347	5.198e-22	100.0	COG1382@1|root,arCOG01342@2157|Archaea,41SPD@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding	pfdB	-	-	ko:K04798	-	-	-	-	ko00000,ko03110	-	-	-	Prefoldin_2
PYH3_k127_7388369_23	1220534.B655_1246	5.772e-06	51.0	COG2892@1|root,arCOG04414@2157|Archaea,2Y1HA@28890|Euryarchaeota,23P8R@183925|Methanobacteria	183925|Methanobacteria	S	Transcription factor Pcc1	-	-	-	ko:K09741	-	-	-	-	ko00000,ko03016	-	-	-	Pcc1
PYH3_k127_7388369_22	453591.Igni_0794	5.201e-06	55.0	COG2136@1|root,arCOG03247@2157|Archaea,2XQKN@28889|Crenarchaeota	28889|Crenarchaeota	J	Probably involved in the biogenesis of the ribosome	-	-	-	ko:K14561	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	-
PYH3_k127_7388369_18	604354.TSIB_1345	7.545e-17	85.0	COG1997@1|root,arCOG04208@2157|Archaea,2XYWD@28890|Euryarchaeota,244K8@183968|Thermococci	183968|Thermococci	J	binds to the 23S rRNA	rpl37ae	-	-	ko:K02921	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L37ae
PYH3_k127_7388369_2	1151117.AJLF01000002_gene83	3.476e-87	296.0	COG2123@1|root,arCOG01574@2157|Archaea,2XWTK@28890|Euryarchaeota,2433E@183968|Thermococci	183968|Thermococci	J	Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site	rrp42	GO:0000177,GO:0000178,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0017091,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1902494,GO:1905354	-	ko:K12589	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	RNase_PH,RNase_PH_C
PYH3_k127_7388369_1	391623.TERMP_00163	2.006e-90	304.0	COG0689@1|root,arCOG01575@2157|Archaea,2XVHI@28890|Euryarchaeota,242PZ@183968|Thermococci	183968|Thermococci	J	Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'- 5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails	rrp41	GO:0000177,GO:0000178,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575,GO:1902494,GO:1905354	-	ko:K11600	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	RNase_PH,RNase_PH_C
PYH3_k127_7388369_9	694429.Pyrfu_1743	4.434e-57	207.0	COG1097@1|root,arCOG00678@2157|Archaea,2XQE2@28889|Crenarchaeota	28889|Crenarchaeota	J	Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome	rrp4	GO:0000178,GO:0000288,GO:0000291,GO:0000459,GO:0000460,GO:0000466,GO:0000467,GO:0000469,GO:0000956,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006364,GO:0006396,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016072,GO:0016073,GO:0016074,GO:0016180,GO:0019222,GO:0019439,GO:0022613,GO:0031123,GO:0031125,GO:0031126,GO:0032991,GO:0034470,GO:0034472,GO:0034475,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0042254,GO:0043144,GO:0043170,GO:0043628,GO:0043928,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071034,GO:0071043,GO:0071051,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1902494,GO:1905354	-	ko:K03679	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	KH_1,KH_6
PYH3_k127_7388369_6	1459636.NTE_01339	1.148e-71	249.0	COG1500@1|root,arCOG04187@2157|Archaea,41SC7@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Shwachman-Bodian-Diamond syndrome (SBDS) protein	-	-	-	ko:K14574	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	SBDS,SBDS_C
PYH3_k127_7388369_4	647113.Metok_0269	2.002e-74	257.0	COG0638@1|root,arCOG00971@2157|Archaea,2XUKA@28890|Euryarchaeota,23QEI@183939|Methanococci	183939|Methanococci	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	psmA	GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0019538,GO:0019773,GO:0030163,GO:0032991,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03432	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome,Proteasome_A_N
PYH3_k127_7388369_24	1227500.C494_17533	4.291e-05	52.0	COG1369@1|root,arCOG01365@2157|Archaea,2XX63@28890|Euryarchaeota,23VN6@183963|Halobacteria	183963|Halobacteria	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp2	-	3.1.26.5	ko:K03537	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03016,ko03029	-	-	-	RNase_P_Rpp14
PYH3_k127_7388369_20	1220534.B655_1256	2.537e-11	73.0	COG1603@1|root,arCOG00307@2157|Archaea,2XU7Q@28890|Euryarchaeota,23P4P@183925|Methanobacteria	183925|Methanobacteria	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp3	-	3.1.26.5	ko:K03539	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03016,ko03029	-	-	-	RNase_P_p30
PYH3_k127_7388369_19	694429.Pyrfu_0825	9.598e-16	84.0	COG1325@1|root,arCOG01042@2157|Archaea,2XQSI@28889|Crenarchaeota	28889|Crenarchaeota	J	exosome subunit	-	-	-	ko:K07581	-	-	-	-	ko00000	-	-	-	RNA_binding
PYH3_k127_7388369_11	195522.BD01_0986	1.053e-49	185.0	COG1409@1|root,arCOG01153@2157|Archaea,2XWZF@28890|Euryarchaeota,242KP@183968|Thermococci	183968|Thermococci	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
PYH3_k127_7388369_15	185453.XP_006833696.1	2.577e-31	126.0	COG1990@1|root,KOG3282@2759|Eukaryota,3A5QT@33154|Opisthokonta,3BSXK@33208|Metazoa,3D9MM@33213|Bilateria,48QWJ@7711|Chordata,49MGJ@7742|Vertebrata,3JPW6@40674|Mammalia,358T4@311790|Afrotheria	33208|Metazoa	S	Peptidyl-tRNA hydrolase PTH2	PTRH2	GO:0003674,GO:0003824,GO:0004045,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009892,GO:0010468,GO:0010605,GO:0010629,GO:0010941,GO:0010942,GO:0016787,GO:0016788,GO:0019222,GO:0042981,GO:0043065,GO:0043066,GO:0043067,GO:0043068,GO:0043069,GO:0044424,GO:0044444,GO:0044464,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0052689,GO:0060255,GO:0060548,GO:0065007,GO:0140098,GO:0140101,GO:2000209,GO:2000210,GO:2000811	3.1.1.29	ko:K04794,ko:K18177	ko04714,map04714	-	-	-	ko00000,ko00001,ko01000,ko03012,ko03029	-	-	-	PTH2
PYH3_k127_7388369_5	1365176.N186_04385	3.649e-74	259.0	COG0142@1|root,arCOG01726@2157|Archaea,2XPZM@28889|Crenarchaeota	28889|Crenarchaeota	H	Belongs to the FPP GGPP synthase family	fgs	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13787	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
PYH3_k127_7409428_3	1125863.JAFN01000001_gene2114	2.472e-63	229.0	COG0226@1|root,COG0226@2|Bacteria,1MVXP@1224|Proteobacteria,42P0G@68525|delta/epsilon subdivisions,2WK7Y@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	TIGRFAM phosphate binding protein	pstS	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
PYH3_k127_7409428_2	1459636.NTE_00452	4.532e-75	265.0	COG0704@1|root,arCOG00318@2157|Archaea,41SC5@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Phosphate uptake regulator	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin,PhoU
PYH3_k127_7409428_5	273063.STK_12370	2.184e-29	125.0	COG5491@1|root,arCOG00452@2157|Archaea,2XQBW@28889|Crenarchaeota	28889|Crenarchaeota	D	Conserved protein implicated in secretion	-	-	-	-	-	-	-	-	-	-	-	-	Snf7
PYH3_k127_7409428_0	883.DvMF_2992	4.561e-268	853.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2WIU0@28221|Deltaproteobacteria,2M7WE@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
PYH3_k127_7409428_4	410358.Mlab_0997	2.793e-41	160.0	COG1392@1|root,arCOG02640@2157|Archaea	2157|Archaea	P	Phosphate transport regulator	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
PYH3_k127_7409428_1	632518.Calow_1264	4.21e-83	286.0	COG0306@1|root,COG0306@2|Bacteria,1TQ3D@1239|Firmicutes,247ZC@186801|Clostridia,42F2R@68295|Thermoanaerobacterales	186801|Clostridia	P	PFAM phosphate transporter	-	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
PYH3_k127_7440917_6	1365176.N186_02675	2.088e-07	55.0	arCOG07440@1|root,arCOG07440@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_7440917_2	1056495.Calag_0487	7.346e-42	165.0	COG2520@1|root,arCOG00033@2157|Archaea,2XPMY@28889|Crenarchaeota	28889|Crenarchaeota	J	Methyltransferase	-	-	2.1.1.228	ko:K15429	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	Met_10
PYH3_k127_7440917_7	930945.SiRe_1557	4.313e-05	48.0	COG1996@1|root,arCOG04341@2157|Archaea	2157|Archaea	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoP	-	2.7.7.6	ko:K03059	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	DNA_RNApol_7kD
PYH3_k127_7440917_5	323259.Mhun_1587	6.28e-10	66.0	COG0727@1|root,arCOG02579@2157|Archaea,2XTK2@28890|Euryarchaeota,2N9XG@224756|Methanomicrobia	224756|Methanomicrobia	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
PYH3_k127_7440917_0	397948.Cmaq_0065	1.472e-117	390.0	COG0012@1|root,arCOG00357@2157|Archaea,2XPTY@28889|Crenarchaeota	28889|Crenarchaeota	J	GTPase of	-	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,MMR_HSR1_C,TGS
PYH3_k127_7440917_3	525904.Tter_1207	2.326e-19	102.0	COG1376@1|root,COG4447@1|root,COG1376@2|Bacteria,COG4447@2|Bacteria,2NQ80@2323|unclassified Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	TIG,VCBS,YkuD
PYH3_k127_7440917_1	178306.PAE2159	5.624e-62	230.0	COG0644@1|root,arCOG00570@2157|Archaea,2XPWV@28889|Crenarchaeota	28889|Crenarchaeota	C	TIGRFAM geranylgeranyl reductase	-	-	1.3.1.101,1.3.7.11	ko:K17830	ko00564,map00564	-	R10325,R10326,R10331	RC03134	ko00000,ko00001,ko01000	-	-	-	DAO,FAD_binding_2,FAD_binding_3,FAD_oxidored,Trp_halogenase
PYH3_k127_7440917_4	1087448.Eab7_2253	3.367e-17	91.0	COG0546@1|root,COG0546@2|Bacteria,1TPPZ@1239|Firmicutes,4HE7X@91061|Bacilli,3WFN6@539002|Bacillales incertae sedis	91061|Bacilli	S	haloacid dehalogenase-like hydrolase	ppaX	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008967,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360	3.6.1.1	ko:K06019	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	HAD_2
PYH3_k127_7465084_4	694431.DESACE_07530	1.514e-35	150.0	COG2223@1|root,COG2223@2|Bacteria,1MXAA@1224|Proteobacteria,43BPJ@68525|delta/epsilon subdivisions,2WK2H@28221|Deltaproteobacteria,2M6U1@213113|Desulfurellales	28221|Deltaproteobacteria	P	Major Facilitator Superfamily	-	-	-	ko:K08223	-	-	-	-	ko00000,ko02000	2.A.1.35	-	-	MFS_1
PYH3_k127_7465084_3	1459636.NTE_00042	6.418e-42	162.0	COG0704@1|root,arCOG00232@2157|Archaea,41T42@651137|Thaumarchaeota	651137|Thaumarchaeota	P	PhoU domain	-	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
PYH3_k127_7465084_0	635013.TherJR_2127	8.575e-105	347.0	COG1117@1|root,COG1117@2|Bacteria,1TP1M@1239|Firmicutes,247RD@186801|Clostridia,260A5@186807|Peptococcaceae	186801|Clostridia	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
PYH3_k127_7465084_1	269797.Mbar_A1780	1.711e-81	280.0	COG0581@1|root,arCOG00168@2157|Archaea,2XTWW@28890|Euryarchaeota,2N9P6@224756|Methanomicrobia	224756|Methanomicrobia	P	Binding-protein-dependent transport system inner membrane component	pstA	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
PYH3_k127_7465084_2	574087.Acear_0863	1.782e-75	263.0	COG0573@1|root,COG0573@2|Bacteria,1TSPP@1239|Firmicutes,249KQ@186801|Clostridia,3WAH0@53433|Halanaerobiales	186801|Clostridia	P	probably responsible for the translocation of the substrate across the membrane	pstC	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
PYH3_k127_7465084_5	945550.VISI1226_15431	1.293e-14	77.0	COG0226@1|root,COG0226@2|Bacteria,1MVXP@1224|Proteobacteria,1RQDH@1236|Gammaproteobacteria,1XTH3@135623|Vibrionales	135623|Vibrionales	P	Phosphate ABC transporter, periplasmic phosphate-binding protein	-	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
PYH3_k127_7502174_5	1459636.NTE_03061	1.066e-42	161.0	COG0842@1|root,arCOG01467@2157|Archaea,41SQQ@651137|Thaumarchaeota	651137|Thaumarchaeota	V	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
PYH3_k127_7502174_3	309801.trd_0142	1.488e-76	269.0	COG0095@1|root,COG0095@2|Bacteria	2|Bacteria	H	Lipoate-protein ligase	-	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB,Lip_prot_lig_C
PYH3_k127_7502174_7	247490.KSU1_C0904	5.517e-17	88.0	COG0170@1|root,COG0560@1|root,COG0170@2|Bacteria,COG0560@2|Bacteria	2|Bacteria	E	Phosphoserine phosphatase	cdsA_1	-	3.1.3.3	ko:K01079,ko:K05967,ko:K07025	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R00582	RC00017	ko00000,ko00001,ko00002,ko01000,ko01009	-	-	-	HAD,NT5C
PYH3_k127_7502174_4	945713.IALB_2866	1.351e-49	180.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	yiiD	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006473,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0009987,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0071704,GO:1901564	-	ko:K06323	-	-	-	-	ko00000	-	-	-	Acetyltransf_1,Acetyltransf_10,YiiD_C
PYH3_k127_7502174_1	710696.Intca_3130	3.284e-100	340.0	COG2141@1|root,COG2141@2|Bacteria,2GJRF@201174|Actinobacteria,4FJQG@85021|Intrasporangiaceae	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	ko:K14728	-	-	-	-	ko00000,ko01000	-	-	-	Bac_luciferase
PYH3_k127_7502174_6	604354.TSIB_0281	3.073e-30	134.0	COG0477@1|root,arCOG00130@2157|Archaea,2Y8EI@28890|Euryarchaeota,242RF@183968|Thermococci	183968|Thermococci	G	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
PYH3_k127_7502174_2	358396.C445_18396	3.132e-96	321.0	COG2057@1|root,arCOG05316@2157|Archaea,2XW2C@28890|Euryarchaeota,23U50@183963|Halobacteria	183963|Halobacteria	I	COG2057 Acyl CoA acetate 3-ketoacid CoA transferase, beta subunit	-	-	2.8.3.12	ko:K01040	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
PYH3_k127_7502174_0	224325.AF_1199	2.556e-134	435.0	COG1788@1|root,arCOG01987@2157|Archaea,2XVRA@28890|Euryarchaeota,246WP@183980|Archaeoglobi	183980|Archaeoglobi	I	Coenzyme A transferase	-	-	2.8.3.12	ko:K01039	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
PYH3_k127_7502174_9	263820.PTO0611	0.0002115	47.0	COG0112@1|root,arCOG00070@2157|Archaea,2XU0H@28890|Euryarchaeota,241JA@183967|Thermoplasmata	183967|Thermoplasmata	E	Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
PYH3_k127_7502174_8	439235.Dalk_4954	2.072e-05	49.0	COG0247@1|root,COG0247@2|Bacteria,1MUMH@1224|Proteobacteria,42S94@68525|delta/epsilon subdivisions,2WNCW@28221|Deltaproteobacteria,2MNBQ@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Cysteine-rich domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG
PYH3_k127_7584778_5	1459636.NTE_03061	1.39e-77	267.0	COG0842@1|root,arCOG01467@2157|Archaea,41SQQ@651137|Thaumarchaeota	651137|Thaumarchaeota	V	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
PYH3_k127_7584778_3	304371.MCP_2633	2.177e-111	370.0	COG1131@1|root,arCOG00194@2157|Archaea,2XUK9@28890|Euryarchaeota,2N95K@224756|Methanomicrobia	224756|Methanomicrobia	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
PYH3_k127_7584778_0	1163671.JAGI01000003_gene514	8.44e-285	902.0	COG0474@1|root,COG0474@2|Bacteria,1TPF5@1239|Firmicutes,249KX@186801|Clostridia,36H4W@31979|Clostridiaceae	186801|Clostridia	P	Cation transporter/ATPase, N-terminus	-	-	-	-	-	-	-	-	-	-	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
PYH3_k127_7584778_7	580327.Tthe_1946	4.268e-57	205.0	COG0569@1|root,COG0569@2|Bacteria,1TPNS@1239|Firmicutes,24830@186801|Clostridia	186801|Clostridia	P	domain protein	-	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
PYH3_k127_7584778_8	1120746.CCNL01000010_gene1351	1.391e-25	111.0	COG0569@1|root,COG0569@2|Bacteria,2NPN3@2323|unclassified Bacteria	2|Bacteria	P	TrkA-C domain	trkA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
PYH3_k127_7584778_10	1304885.AUEY01000026_gene3577	6.707e-07	57.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	gloA	-	3.2.2.1	ko:K01239,ko:K08234	ko00230,ko00760,ko01100,map00230,map00760,map01100	-	R01245,R01273,R01677,R01770,R02143	RC00033,RC00063,RC00122,RC00318,RC00485	ko00000,ko00001,ko01000	-	-	-	Glyoxalase,Glyoxalase_4
PYH3_k127_7584778_4	696369.KI912183_gene1157	5.101e-85	296.0	COG1454@1|root,COG1454@2|Bacteria,1TPB4@1239|Firmicutes,247IQ@186801|Clostridia	186801|Clostridia	C	alcohol dehydrogenase	-	-	-	ko:K19954	-	-	-	-	ko00000,ko01000	-	-	-	Fe-ADH
PYH3_k127_7584778_2	1123371.ATXH01000001_gene1323	7.021e-159	525.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,2GH97@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	C	Succinyl-CoA ligase like flavodoxin domain	-	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
PYH3_k127_7584778_1	1449126.JQKL01000014_gene3030	2.414e-173	563.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,26A1J@186813|unclassified Clostridiales	186801|Clostridia	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
PYH3_k127_7584778_6	1238184.CM001792_gene3038	1.394e-68	241.0	COG1028@1|root,COG1028@2|Bacteria,1TPZ8@1239|Firmicutes,4HCS5@91061|Bacilli	91061|Bacilli	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
PYH3_k127_7584778_9	935837.JAEK01000023_gene1196	7.895e-19	88.0	COG1352@1|root,COG2201@1|root,COG4191@1|root,COG1352@2|Bacteria,COG2201@2|Bacteria,COG4191@2|Bacteria,1VCNJ@1239|Firmicutes,4HVBX@91061|Bacilli,1ZS41@1386|Bacillus	91061|Bacilli	T	Histidine kinase	-	-	2.1.1.80,3.1.1.61	ko:K13924	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,CheR,CheR_N,HATPase_c,HisKA,PAS_10,PAS_4,PAS_9
PYH3_k127_7713540_2	525904.Tter_2623	3.605e-85	291.0	COG1060@1|root,COG1060@2|Bacteria,2NP8W@2323|unclassified Bacteria	2|Bacteria	H	Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2)	fbiC	-	1.21.98.1,2.5.1.77	ko:K11779,ko:K11784	ko00130,ko00680,ko01110,ko01120,map00130,map00680,map01110,map01120	M00378	R08588,R09396	RC01381,RC02329,RC03002,RC03007	ko00000,ko00001,ko00002,ko01000	-	-	-	CofC,Radical_SAM
PYH3_k127_7713540_7	573063.Metin_1271	7.001e-61	218.0	COG1985@1|root,arCOG01484@2157|Archaea,2XU47@28890|Euryarchaeota,23QM6@183939|Methanococci	183939|Methanococci	H	PFAM bifunctional deaminase-reductase domain protein	-	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006139,GO:0006725,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009451,GO:0009987,GO:0016070,GO:0016491,GO:0016614,GO:0016616,GO:0017144,GO:0018130,GO:0034641,GO:0036094,GO:0042364,GO:0042726,GO:0042727,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0046983,GO:0048037,GO:0050661,GO:0050662,GO:0051287,GO:0055114,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	1.1.1.302	ko:K14654	ko00740,ko01100,map00740,map01100	-	R09375,R09376	RC00933	ko00000,ko00001,ko01000	-	-	-	RibD_C,Toprim_2
PYH3_k127_7713540_4	1459636.NTE_03546	1.003e-71	257.0	COG0402@1|root,arCOG00692@2157|Archaea,41S61@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
PYH3_k127_7713540_6	877455.Metbo_2437	1.756e-68	242.0	COG2429@1|root,arCOG04202@2157|Archaea,2XSWH@28890|Euryarchaeota,23NUD@183925|Methanobacteria	183925|Methanobacteria	F	Catalyzes the formation of 2-amino-5-formylamino-6- ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity	gch3	-	3.5.4.29	ko:K08096	ko00740,ko01100,map00740,map01100	-	R07306	RC01790	ko00000,ko00001,ko01000	-	-	-	GCH_III
PYH3_k127_7713540_8	323259.Mhun_3201	1.119e-26	114.0	COG0745@1|root,arCOG02595@2157|Archaea	2157|Archaea	T	response regulator, receiver	-	-	-	ko:K07669	ko02020,map02020	M00460	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg
PYH3_k127_7713540_5	1379698.RBG1_1C00001G1718	1.481e-68	247.0	COG0438@1|root,COG0438@2|Bacteria,2NNZH@2323|unclassified Bacteria	2|Bacteria	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
PYH3_k127_7713540_3	518766.Rmar_2615	1.051e-73	258.0	COG2152@1|root,COG2152@2|Bacteria,4NG7B@976|Bacteroidetes	976|Bacteroidetes	G	PFAM glycosidase, PH1107-related	-	-	2.4.1.339,2.4.1.340	ko:K20885	-	-	R11397,R11398	RC00049,RC02748	ko00000,ko01000	-	GH130	-	Glyco_hydro_130
PYH3_k127_7713540_1	518766.Rmar_1363	3.08e-100	346.0	COG0438@1|root,COG0438@2|Bacteria,4NEW7@976|Bacteroidetes	976|Bacteroidetes	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
PYH3_k127_7713540_9	204536.SULAZ_1315	2.524e-11	76.0	COG0517@1|root,COG2199@1|root,COG2905@1|root,COG0517@2|Bacteria,COG2905@2|Bacteria,COG3706@2|Bacteria,2G47E@200783|Aquificae	200783|Aquificae	T	GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,GGDEF
PYH3_k127_7713540_0	1487923.DP73_14175	3.554e-107	357.0	COG0491@1|root,COG0491@2|Bacteria,1TQPX@1239|Firmicutes,24BDQ@186801|Clostridia,261Z4@186807|Peptococcaceae	186801|Clostridia	S	Zn-dependent hydrolase, glyoxylase	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
PYH3_k127_7762561_1	273057.SSO0469	4.197e-67	250.0	COG0433@1|root,arCOG00283@2157|Archaea,2XST3@28889|Crenarchaeota	28889|Crenarchaeota	L	AAA-like domain	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF87
PYH3_k127_7762561_2	1121346.KB899821_gene2714	2.11e-65	233.0	COG2084@1|root,COG2084@2|Bacteria,1TR4F@1239|Firmicutes,4H9MA@91061|Bacilli,26QSG@186822|Paenibacillaceae	91061|Bacilli	I	3-hydroxyisobutyrate dehydrogenase	hopR	-	1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2,PilZ
PYH3_k127_7762561_7	1128421.JAGA01000002_gene910	4.869e-06	49.0	2DQ8Q@1|root,335AV@2|Bacteria,2NQY5@2323|unclassified Bacteria	2|Bacteria	S	F420H(2)-dependent quinone reductase	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red
PYH3_k127_7762561_8	383372.Rcas_1279	0.0006973	45.0	2DQ8Q@1|root,335AV@2|Bacteria,2G9D1@200795|Chloroflexi	200795|Chloroflexi	S	pyridoxamine 5'-phosphate oxidase-related, FMN-binding	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red
PYH3_k127_7762561_0	1183377.Py04_1720	8.02e-100	342.0	COG1042@1|root,arCOG01340@2157|Archaea,2XT9G@28890|Euryarchaeota,243Q6@183968|Thermococci	183968|Thermococci	C	CoA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding_2,Succ_CoA_lig
PYH3_k127_7762561_3	694429.Pyrfu_1064	3.792e-46	183.0	COG0683@1|root,arCOG01020@2157|Archaea,2XQM1@28889|Crenarchaeota	28889|Crenarchaeota	E	Periplasmic binding protein	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
PYH3_k127_7762561_5	1121381.JNIV01000007_gene2221	1.341e-08	63.0	COG2318@1|root,COG2318@2|Bacteria	2|Bacteria	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB
PYH3_k127_7762561_4	1179773.BN6_58260	1.672e-16	93.0	COG2234@1|root,COG3979@1|root,COG2234@2|Bacteria,COG3979@2|Bacteria,2GIT0@201174|Actinobacteria,4EFDV@85010|Pseudonocardiales	201174|Actinobacteria	O	Peptidase family M28	-	-	3.4.11.24	ko:K19702	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	FTP,P_proprotein,Peptidase_M28,Peptidase_M4,Peptidase_M4_C
PYH3_k127_7762561_6	579137.Metvu_1353	6.529e-07	59.0	arCOG06562@1|root,arCOG06562@2157|Archaea,2Y5QT@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_7785063_2	1461582.BN1048_01761	1.39e-05	54.0	COG0477@1|root,COG2814@2|Bacteria,1TQHD@1239|Firmicutes,4HBCZ@91061|Bacilli,4GWWE@90964|Staphylococcaceae	91061|Bacilli	EGP	Major facilitator	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
PYH3_k127_7785063_1	269797.Mbar_A1859	2.88e-21	97.0	COG0526@1|root,arCOG01972@2157|Archaea,2XZVP@28890|Euryarchaeota,2NA27@224756|Methanomicrobia	224756|Methanomicrobia	O	Thioredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin
PYH3_k127_7785063_3	593750.Metfor_2439	0.0002197	47.0	arCOG03911@1|root,arCOG03911@2157|Archaea	2157|Archaea	S	membrane protein (DUF2078)	-	-	-	ko:K08982	-	-	-	-	ko00000	-	-	-	SHOCT
PYH3_k127_7785063_0	1162668.LFE_1240	1.748e-36	144.0	COG1765@1|root,COG1765@2|Bacteria	1162668.LFE_1240|-	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_7863164_11	868131.MSWAN_2069	6.864e-08	53.0	COG3269@1|root,arCOG01641@2157|Archaea,2Y1N9@28890|Euryarchaeota	28890|Euryarchaeota	S	PFAM Deoxyribonuclease rho motif-related TRAM	-	-	-	-	-	-	-	-	-	-	-	-	TRAM
PYH3_k127_7863164_9	693661.Arcve_1029	9.6e-10	67.0	COG2047@1|root,arCOG00348@2157|Archaea,2XSX4@28890|Euryarchaeota,2463Z@183980|Archaeoglobi	183980|Archaeoglobi	S	PAC2 family	-	-	-	ko:K07159	-	-	-	-	ko00000	-	-	-	PAC2
PYH3_k127_7863164_2	868131.MSWAN_1961	3.427e-128	424.0	COG1571@1|root,arCOG01115@2157|Archaea,2XTGD@28890|Euryarchaeota,23NMB@183925|Methanobacteria	183925|Methanobacteria	J	ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA	tiaS	-	6.3.4.22	ko:K06932	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1743,tRNA_anti-codon
PYH3_k127_7863164_6	1163730.FFONT_0808	2.319e-27	113.0	COG1522@1|root,arCOG01117@2157|Archaea,2XR1K@28889|Crenarchaeota	28889|Crenarchaeota	K	PFAM regulatory protein AsnC Lrp family	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
PYH3_k127_7863164_1	933801.Ahos_2288	1.107e-146	481.0	COG0063@1|root,arCOG00018@2157|Archaea,2XPXN@28889|Crenarchaeota	28889|Crenarchaeota	G	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
PYH3_k127_7863164_5	436308.Nmar_0617	2.119e-34	138.0	COG2042@1|root,arCOG04733@2157|Archaea,41SMC@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Ribosome biogenesis protein, C-terminal	-	-	-	ko:K09140	-	-	-	-	ko00000,ko03009	-	-	-	RLI,Ribo_biogen_C
PYH3_k127_7863164_3	457415.HMPREF1006_01226	3.259e-49	183.0	COG2109@1|root,COG2109@2|Bacteria,3TB75@508458|Synergistetes	508458|Synergistetes	H	PFAM ATP corrinoid adenosyltransferase BtuR CobO CobP	-	-	2.5.1.17	ko:K19221	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	CobA_CobO_BtuR
PYH3_k127_7863164_10	195522.BD01_0509	5.659e-09	65.0	COG3363@1|root,arCOG04727@2157|Archaea,2XTEV@28890|Euryarchaeota,243RW@183968|Thermococci	183968|Thermococci	F	Catalyzes the cyclization of 5-formylamidoimidazole-4- carboxamide ribonucleotide to IMP	purO	-	3.5.4.10	ko:K11176	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R01127	RC00456	ko00000,ko00001,ko00002,ko01000	-	-	-	IMP_cyclohyd
PYH3_k127_7863164_8	243164.DET1403	5.215e-17	94.0	COG4249@1|root,COG4249@2|Bacteria,2GARQ@200795|Chloroflexi,34D6K@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Peptidase C13 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14
PYH3_k127_7863164_4	1365176.N186_05185	5.714e-38	154.0	COG1829@1|root,arCOG04263@2157|Archaea,2XQG1@28889|Crenarchaeota	28889|Crenarchaeota	S	kinase, sugar kinase superfamily	-	-	2.7.1.169	ko:K06982	ko00770,ko01100,map00770,map01100	-	R09378	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	GHMP_kinases_N
PYH3_k127_7863164_12	415426.Hbut_0677	2.523e-07	62.0	arCOG10417@1|root,arCOG10417@2157|Archaea,2XSG1@28889|Crenarchaeota	28889|Crenarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_7863164_0	1089553.Tph_c19800	2.197e-147	488.0	COG0119@1|root,COG0119@2|Bacteria,1TRIK@1239|Firmicutes,249Q4@186801|Clostridia,42EVB@68295|Thermoanaerobacterales	186801|Clostridia	E	Belongs to the alpha-IPM synthase homocitrate synthase family	leuA3	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
PYH3_k127_7894154_1	555079.Toce_0156	4.593e-159	510.0	COG0137@1|root,COG0137@2|Bacteria,1TP3X@1239|Firmicutes,247MF@186801|Clostridia,42EKQ@68295|Thermoanaerobacterales	186801|Clostridia	F	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	-	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
PYH3_k127_7894154_10	1459636.NTE_00733	2.339e-84	288.0	COG0189@1|root,arCOG01589@2157|Archaea,41SCQ@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Lysine biosynthesis	-	-	6.3.2.43	ko:K05827	ko00300,ko01100,ko01210,ko01230,map00300,map01100,map01210,map01230	M00031	R09775	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	RimK
PYH3_k127_7894154_15	1459636.NTE_01583	1.168e-14	76.0	arCOG01588@1|root,arCOG01588@2157|Archaea,41STK@651137|Thaumarchaeota	651137|Thaumarchaeota	E	lysine biosynthesis protein LysW	-	-	-	ko:K05826	-	M00031,M00763	-	-	ko00000,ko00001,ko00002	-	-	-	-
PYH3_k127_7894154_14	1459636.NTE_00737	1.016e-37	146.0	COG1522@1|root,arCOG01580@2157|Archaea,41SNE@651137|Thaumarchaeota	651137|Thaumarchaeota	K	helix_turn_helix ASNC type	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_AsnC-type
PYH3_k127_7894154_16	436308.Nmar_1287	2.71e-11	66.0	arCOG01588@1|root,arCOG01588@2157|Archaea,41SVX@651137|Thaumarchaeota	651137|Thaumarchaeota	E	lysine biosynthesis protein LysW	-	-	-	ko:K05826	-	M00031,M00763	-	-	ko00000,ko00001,ko00002	-	-	-	-
PYH3_k127_7894154_8	1459636.NTE_01582	2.37e-89	302.0	COG0189@1|root,arCOG01589@2157|Archaea,41SE8@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Lysine biosynthesis	-	-	6.3.2.43	ko:K05827	ko00300,ko01100,ko01210,ko01230,map00300,map01100,map01210,map01230	M00031	R09775	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	RimK
PYH3_k127_7894154_5	1131266.ARWQ01000004_gene1453	9.571e-133	431.0	COG0002@1|root,arCOG00495@2157|Archaea,41S8R@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily	lysY	-	-	ko:K05829	ko00220,ko00300,ko01100,ko01110,ko01210,ko01230,map00220,map00300,map01100,map01110,map01210,map01230	M00031,M00763	R09777,R10931	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
PYH3_k127_7894154_11	1131266.ARWQ01000004_gene1454	1.338e-83	285.0	COG0548@1|root,arCOG00862@2157|Archaea,41SFB@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis)	lysZ	-	-	ko:K05828	ko00220,ko00300,ko01100,ko01110,ko01210,ko01230,map00220,map00300,map01100,map01110,map01210,map01230	M00031,M00763	R09776,R10930	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
PYH3_k127_7894154_6	1459636.NTE_00736	8.702e-131	428.0	COG4992@1|root,arCOG00914@2157|Archaea,41SC8@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	lysJ	-	-	ko:K05830	ko00220,ko00300,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01130,map01210,map01230	M00031,M00763	R09778,R10932	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
PYH3_k127_7894154_9	1459636.NTE_01581	1.66e-88	304.0	COG0624@1|root,arCOG01107@2157|Archaea,41SAX@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Catalyzes the release of L-lysine from LysW -gamma-L- lysine and the release of L-ornithine from LysW -L-ornithine	lysK	-	-	ko:K05831	ko00220,ko00300,ko01100,ko01210,ko01230,map00220,map00300,map01100,map01210,map01230	M00031,M00763	R09779,R10933	RC00064,RC00090	ko00000,ko00001,ko00002	-	-	-	M20_dimer,Peptidase_M20
PYH3_k127_7894154_3	933801.Ahos_1431	1.552e-146	477.0	COG0119@1|root,arCOG02092@2157|Archaea,2XQ53@28889|Crenarchaeota	28889|Crenarchaeota	E	Homocitrate synthase	-	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	AsnC_trans_reg,HMGL-like
PYH3_k127_7894154_0	1459636.NTE_02178	8.635e-210	666.0	COG0028@1|root,arCOG01998@2157|Archaea,41S63@651137|Thaumarchaeota	651137|Thaumarchaeota	E	TIGRFAM acetolactate synthase, large subunit, biosynthetic type	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
PYH3_k127_7894154_13	386456.JQKN01000015_gene2928	3.179e-53	192.0	COG0440@1|root,arCOG04445@2157|Archaea,2XVFX@28890|Euryarchaeota,23P3W@183925|Methanobacteria	183925|Methanobacteria	E	Acetolactate synthase, small subunit	ilvN	-	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,ACT_5,ALS_ss_C
PYH3_k127_7894154_4	342949.PNA2_1345	6.921e-134	434.0	COG0059@1|root,arCOG04465@2157|Archaea,2XTGU@28890|Euryarchaeota,242YF@183968|Thermococci	183968|Thermococci	E	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
PYH3_k127_7894154_2	386456.JQKN01000008_gene1469	5.525e-149	484.0	COG0065@1|root,arCOG01698@2157|Archaea,2XTWH@28890|Euryarchaeota,23NPF@183925|Methanobacteria	183925|Methanobacteria	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	aksD	-	4.2.1.114	ko:K16792	ko00300,ko00680,ko01100,ko01120,ko01130,ko01210,ko01230,map00300,map00680,map01100,map01120,map01130,map01210,map01230	M00433,M00608	R03444,R04371,R09720,R10391,R10392,R10393,R10394,R10395,R10396	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
PYH3_k127_7894154_12	1304880.JAGB01000004_gene1484	6.111e-56	199.0	COG0066@1|root,COG0066@2|Bacteria,1V1I6@1239|Firmicutes,24FUI@186801|Clostridia	186801|Clostridia	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
PYH3_k127_7894154_7	1123376.AUIU01000013_gene1818	4.044e-120	389.0	COG0473@1|root,COG0473@2|Bacteria,3J0JQ@40117|Nitrospirae	40117|Nitrospirae	C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
PYH3_k127_8173281_4	589924.Ferp_1683	8.1e-46	180.0	COG0683@1|root,arCOG01020@2157|Archaea,2XVWV@28890|Euryarchaeota,245XV@183980|Archaeoglobi	183980|Archaeoglobi	E	Periplasmic binding protein domain	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
PYH3_k127_8173281_3	309807.SRU_1457	1.212e-59	218.0	COG1335@1|root,COG1335@2|Bacteria,4NKPP@976|Bacteroidetes,1FIZM@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	Q	Isochorismatase family	pncA	-	3.5.1.19	ko:K08281	ko00760,ko01100,map00760,map01100	-	R01268	RC00100	ko00000,ko00001,ko01000	-	-	-	Isochorismatase
PYH3_k127_8173281_5	589924.Ferp_1683	4.536e-45	180.0	COG0683@1|root,arCOG01020@2157|Archaea,2XVWV@28890|Euryarchaeota,245XV@183980|Archaeoglobi	183980|Archaeoglobi	E	Periplasmic binding protein domain	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
PYH3_k127_8173281_10	604354.TSIB_0281	8.068e-22	108.0	COG0477@1|root,arCOG00130@2157|Archaea,2Y8EI@28890|Euryarchaeota,242RF@183968|Thermococci	183968|Thermococci	G	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
PYH3_k127_8173281_2	593750.Metfor_2107	5.439e-64	224.0	COG4802@1|root,arCOG01100@2157|Archaea,2XXWK@28890|Euryarchaeota,2NAWN@224756|Methanomicrobia	224756|Methanomicrobia	C	Ferredoxin thioredoxin reductase catalytic beta chain	-	-	-	-	-	-	-	-	-	-	-	-	FeThRed_B
PYH3_k127_8173281_7	386456.JQKN01000001_gene2349	9.928e-34	132.0	COG0695@1|root,arCOG02606@2157|Archaea,2Y0MA@28890|Euryarchaeota	28890|Euryarchaeota	O	PFAM glutaredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Glutaredoxin
PYH3_k127_8173281_0	485916.Dtox_0814	1.639e-100	338.0	COG0205@1|root,COG0205@2|Bacteria,1TPF4@1239|Firmicutes,248PB@186801|Clostridia,2603F@186807|Peptococcaceae	186801|Clostridia	G	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	pfkA	-	2.7.1.11	ko:K00850	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
PYH3_k127_8173281_8	269799.Gmet_2233	2.952e-30	131.0	COG0491@1|root,COG0491@2|Bacteria,1MXKX@1224|Proteobacteria,42R8E@68525|delta/epsilon subdivisions,2WN6V@28221|Deltaproteobacteria,43TY5@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
PYH3_k127_8173281_9	693661.Arcve_0343	7.532e-27	126.0	COG0607@1|root,arCOG02021@2157|Archaea,2XY1R@28890|Euryarchaeota,246BX@183980|Archaeoglobi	183980|Archaeoglobi	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
PYH3_k127_8173281_6	386456.JQKN01000012_gene1046	2.344e-35	141.0	COG0778@1|root,arCOG00288@2157|Archaea,2XZHP@28890|Euryarchaeota	28890|Euryarchaeota	C	Putative TM nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase,TM1586_NiRdase
PYH3_k127_8173281_1	935567.JAES01000001_gene2285	7.171e-66	233.0	COG1236@1|root,COG1236@2|Bacteria,1MUDD@1224|Proteobacteria,1RPZC@1236|Gammaproteobacteria,1X523@135614|Xanthomonadales	135614|Xanthomonadales	J	exonuclease of the beta-lactamase fold involved in RNA processing	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,RMMBL
PYH3_k127_8183405_7	368408.Tpen_1050	3.285e-28	120.0	arCOG09435@1|root,arCOG09435@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_8183405_2	877455.Metbo_0069	7.835e-69	249.0	COG4012@1|root,arCOG04365@2157|Archaea,2XUWU@28890|Euryarchaeota,23PCC@183925|Methanobacteria	183925|Methanobacteria	S	Putative pyruvate format-lyase activating enzyme (DUF1786)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1786
PYH3_k127_8183405_6	289376.THEYE_A1926	2.698e-31	127.0	COG3118@1|root,COG3118@2|Bacteria,3J0P6@40117|Nitrospirae	40117|Nitrospirae	O	Thioredoxin-like domain	-	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
PYH3_k127_8183405_10	387631.Asulf_02068	2.213e-07	62.0	COG1378@1|root,arCOG02038@2157|Archaea	2157|Archaea	K	transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	Regulator_TrmB,TrmB
PYH3_k127_8183405_8	515635.Dtur_0654	2.69e-22	102.0	COG1833@1|root,COG1833@2|Bacteria	2|Bacteria	J	Belongs to the SfsA family	sfsA	-	6.1.1.21	ko:K01892,ko:K06206	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DUF123,SfsA
PYH3_k127_8183405_3	1184251.TCELL_0842	4.257e-62	230.0	COG1109@1|root,COG1208@1|root,arCOG00666@2157|Archaea,arCOG00767@2157|Archaea,2XRVU@28889|Crenarchaeota	28889|Crenarchaeota	M	transferase hexapeptide repeat containing protein	-	-	2.7.7.13,5.4.2.8	ko:K00966,ko:K16881	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114,M00361,M00362	R00885,R01818	RC00002,RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase,PGM_PMM_I,PGM_PMM_II,PGM_PMM_III
PYH3_k127_8183405_0	694429.Pyrfu_1421	3.427e-128	424.0	COG1109@1|root,arCOG00767@2157|Archaea,2XPXR@28889|Crenarchaeota	28889|Crenarchaeota	G	Belongs to the phosphohexose mutase family	-	-	5.4.2.10,5.4.2.2,5.4.2.8	ko:K01840,ko:K03431,ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R02060,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
PYH3_k127_8183405_5	374847.Kcr_1445	1.438e-36	151.0	COG0472@1|root,arCOG03199@2157|Archaea	2157|Archaea	M	PFAM Glycosyl transferase family 4	-	-	2.7.8.15	ko:K01001	ko00510,ko01100,map00510,map01100	M00055	R05969	RC00002	ko00000,ko00001,ko00002,ko01000,ko01003	-	-	-	Glycos_transf_4
PYH3_k127_8183405_4	1459636.NTE_02312	8.515e-54	202.0	COG1817@1|root,arCOG01395@2157|Archaea,41S8D@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Protein of unknown function (DUF354)	-	-	-	ko:K09726	-	-	-	-	ko00000	-	-	-	DUF354
PYH3_k127_8183405_1	1163730.FFONT_0918	7.89e-89	309.0	COG0677@1|root,arCOG00252@2157|Archaea,2XQDG@28889|Crenarchaeota	28889|Crenarchaeota	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	-	-	1.1.1.336	ko:K02472	ko00520,ko05111,map00520,map05111	-	R03317	RC00291	ko00000,ko00001,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
PYH3_k127_8183405_11	401526.TcarDRAFT_2535	5.548e-06	51.0	COG0334@1|root,COG0334@2|Bacteria,1TP45@1239|Firmicutes,4H2M1@909932|Negativicutes	909932|Negativicutes	E	Belongs to the Glu Leu Phe Val dehydrogenases family	gdhA	-	1.4.1.3,1.4.1.4	ko:K00261,ko:K00262	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
PYH3_k127_8183405_9	436308.Nmar_0246	5.079e-22	96.0	COG2835@1|root,arCOG04124@2157|Archaea,41STB@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Trm112p-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Trm112p
PYH3_k127_8189337_3	525904.Tter_2722	8.456e-23	101.0	COG0640@1|root,COG0640@2|Bacteria,2NQ74@2323|unclassified Bacteria	2|Bacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_20,HTH_5
PYH3_k127_8189337_1	374847.Kcr_1538	1.122e-51	187.0	COG2210@1|root,arCOG02064@2157|Archaea	2157|Archaea	S	DsrE/DsrF/DrsH-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE_2
PYH3_k127_8189337_4	1408303.JNJJ01000016_gene213	3.167e-19	89.0	COG0446@1|root,COG0607@1|root,COG0446@2|Bacteria,COG0607@2|Bacteria,1TPWW@1239|Firmicutes,4HA11@91061|Bacilli,1ZATE@1386|Bacillus	91061|Bacilli	P	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	DrsE_2,Pyr_redox_2,Pyr_redox_dim,Rhodanese,TusA
PYH3_k127_8189337_2	1449126.JQKL01000042_gene1027	8.582e-33	136.0	COG2181@1|root,COG2181@2|Bacteria,1V6BS@1239|Firmicutes,249A5@186801|Clostridia	186801|Clostridia	C	PFAM Nitrate reductase gamma subunit	-	-	-	-	-	-	-	-	-	-	-	-	Nitrate_red_gam
PYH3_k127_8189337_0	246194.CHY_2406	8.176e-100	341.0	COG0247@1|root,COG0247@2|Bacteria,1UZQ0@1239|Firmicutes,24E5H@186801|Clostridia,42F8Q@68295|Thermoanaerobacterales	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_17
PYH3_k127_8619666_0	720554.Clocl_1771	8.587e-112	365.0	COG0107@1|root,COG0107@2|Bacteria,1TP0W@1239|Firmicutes,24900@186801|Clostridia,3WGQE@541000|Ruminococcaceae	186801|Clostridia	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	-	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS05755	His_biosynth
PYH3_k127_8619666_4	1365176.N186_07220	3.541e-17	87.0	arCOG03871@1|root,arCOG03871@2157|Archaea,2XRGZ@28889|Crenarchaeota	28889|Crenarchaeota	N	TIGRFAM archaeal flagellin N-terminal-like domain	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_8619666_2	491205.JARQ01000001_gene646	3.475e-51	193.0	COG1073@1|root,COG1073@2|Bacteria,4PFZM@976|Bacteroidetes,1IISB@117743|Flavobacteriia,3ZS27@59732|Chryseobacterium	976|Bacteroidetes	S	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_8619666_5	273075.Ta0785	2.534e-16	87.0	COG3371@1|root,arCOG02008@2157|Archaea,2Y1QQ@28890|Euryarchaeota,242HN@183967|Thermoplasmata	183967|Thermoplasmata	S	Protein of unknown function (DUF998)	-	-	-	-	-	-	-	-	-	-	-	-	DUF998
PYH3_k127_8619666_1	2325.TKV_c18760	6.215e-93	316.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,247V1@186801|Clostridia,42EQG@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM NADH flavin oxidoreductase NADH oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN,Pyr_redox_2
PYH3_k127_8619666_3	646529.Desaci_1421	1.655e-44	164.0	COG3370@1|root,COG3370@2|Bacteria,1VC7H@1239|Firmicutes,24PJC@186801|Clostridia,265XN@186807|Peptococcaceae	186801|Clostridia	S	PFAM DsrE DsrF-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE
PYH3_k127_868818_0	70601.3258205	4.087e-58	211.0	COG0092@1|root,arCOG04097@2157|Archaea,2XTHR@28890|Euryarchaeota,243EH@183968|Thermococci	183968|Thermococci	J	Binds the lower part of the 30S subunit head	rps3	GO:0000702,GO:0002181,GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003735,GO:0003824,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006259,GO:0006281,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008534,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
PYH3_k127_868818_6	1041930.Mtc_1329	6.051e-09	59.0	COG0255@1|root,arCOG00785@2157|Archaea,2XZUQ@28890|Euryarchaeota,2NA4R@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the universal ribosomal protein uL29 family	rpl29	-	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
PYH3_k127_868818_5	868131.MSWAN_1462	1.827e-22	99.0	COG1588@1|root,arCOG00784@2157|Archaea,2Y0EN@28890|Euryarchaeota,23PQP@183925|Methanobacteria	183925|Methanobacteria	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp1	-	3.1.26.5	ko:K03538	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03016,ko03029	-	-	-	UPF0086
PYH3_k127_868818_2	521011.Mpal_0451	3.097e-35	137.0	COG0186@1|root,arCOG04096@2157|Archaea,2XYPE@28890|Euryarchaeota,2N9XI@224756|Methanomicrobia	224756|Methanomicrobia	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rps17	-	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
PYH3_k127_868818_1	1459636.NTE_01827	4.804e-51	184.0	COG0093@1|root,arCOG04095@2157|Archaea,41SHG@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rpl14	-	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
PYH3_k127_868818_4	633148.Tagg_0858	1.765e-25	109.0	COG0198@1|root,arCOG04094@2157|Archaea,2XQQB@28889|Crenarchaeota	28889|Crenarchaeota	J	Located at the polypeptide exit tunnel on the outside of the subunit	rpl24	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,Ribosomal_L26
PYH3_k127_868818_3	453591.Igni_1410	4.206e-26	109.0	COG1471@1|root,arCOG04093@2157|Archaea,2XPPZ@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eS4 family	rps4e	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02987	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	RS4NT,Ribosomal_S4e,S4
PYH3_k127_8710491_0	877455.Metbo_1245	2.918e-46	179.0	COG0053@1|root,arCOG01475@2157|Archaea,2Y8CZ@28890|Euryarchaeota	28890|Euryarchaeota	P	TIGRFAM cation diffusion facilitator family transporter	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,Nitro_FeMo-Co,ZT_dimer
PYH3_k127_8710491_1	1229485.AMYV01000086_gene2751	1.195e-33	132.0	COG5507@1|root,COG5507@2|Bacteria,1RH3Q@1224|Proteobacteria,1SF1D@1236|Gammaproteobacteria,1JBJF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	NIPSNAP	-	-	-	-	-	-	-	-	-	-	-	-	NIPSNAP
PYH3_k127_8733911_0	368408.Tpen_0497	4.199e-182	592.0	COG1241@1|root,arCOG00439@2157|Archaea,2XQ2Z@28889|Crenarchaeota	28889|Crenarchaeota	L	Belongs to the MCM family	-	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K10726	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	Intein_splicing,MCM,MCM_N,MCM_OB
PYH3_k127_8733911_2	694429.Pyrfu_0369	1.378e-10	69.0	arCOG00552@1|root,arCOG00552@2157|Archaea,2XR6J@28889|Crenarchaeota	28889|Crenarchaeota	L	GINS complex protein	-	-	-	ko:K09723	-	-	-	-	ko00000,ko03032	-	-	-	Sld5
PYH3_k127_8733911_1	694429.Pyrfu_1064	1.761e-17	89.0	COG0683@1|root,arCOG01020@2157|Archaea,2XQM1@28889|Crenarchaeota	28889|Crenarchaeota	E	Periplasmic binding protein	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
PYH3_k127_8797790_2	525904.Tter_0750	2.853e-11	67.0	COG0123@1|root,COG0123@2|Bacteria,2NP8V@2323|unclassified Bacteria	2|Bacteria	BQ	Histone deacetylase domain	-	-	-	ko:K04768	-	-	-	-	ko00000	-	-	-	Hist_deacetyl
PYH3_k127_8797790_0	909663.KI867149_gene3218	9.364e-97	329.0	COG2271@1|root,COG2271@2|Bacteria,1QX38@1224|Proteobacteria,42NSX@68525|delta/epsilon subdivisions,2WK8G@28221|Deltaproteobacteria,2MSIF@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	Uncharacterised MFS-type transporter YbfB	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_4,Sugar_tr
PYH3_k127_8797790_1	273063.STK_06230	1.931e-71	248.0	COG0308@1|root,arCOG02969@2157|Archaea,2XRK6@28889|Crenarchaeota	28889|Crenarchaeota	E	peptide catabolic process	ape2	-	-	ko:K13722	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	ERAP1_C,Peptidase_M1
PYH3_k127_8825333_3	204669.Acid345_1869	3.758e-62	228.0	COG0577@1|root,COG0577@2|Bacteria,3Y36A@57723|Acidobacteria,2JIYT@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
PYH3_k127_8825333_2	717231.Flexsi_1874	1.349e-72	251.0	COG1136@1|root,COG1136@2|Bacteria,2GFQJ@200930|Deferribacteres	200930|Deferribacteres	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
PYH3_k127_8825333_6	63737.Npun_R0694	6.06e-06	50.0	COG0631@1|root,COG0631@2|Bacteria,1FZZK@1117|Cyanobacteria,1HJGG@1161|Nostocales	1117|Cyanobacteria	T	PFAM protein phosphatase 2C	-	-	3.1.3.16	ko:K01090	-	-	-	-	ko00000,ko01000	-	-	-	DZR,PP2C_2
PYH3_k127_8825333_5	1448860.BBJO01000009_gene694	6.808e-13	81.0	COG2304@1|root,arCOG02902@2157|Archaea,2XZJD@28890|Euryarchaeota,23X73@183963|Halobacteria	183963|Halobacteria	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA
PYH3_k127_8825333_1	1459636.NTE_02780	1.531e-89	310.0	COG1641@1|root,arCOG02701@2157|Archaea,41SDC@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Protein of unknown function DUF111	-	-	4.99.1.12	ko:K09121	-	-	-	-	ko00000,ko01000	-	-	-	DUF111
PYH3_k127_8825333_7	697281.Mahau_1555	4.083e-05	55.0	2EIBY@1|root,33C3A@2|Bacteria,1VQ1V@1239|Firmicutes,24FGH@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_8825333_0	768706.Desor_0383	2.254e-99	341.0	COG0477@1|root,COG2814@2|Bacteria,1TPRN@1239|Firmicutes,249RZ@186801|Clostridia,263IU@186807|Peptococcaceae	186801|Clostridia	U	TIGRFAM drug resistance transporter, EmrB QacA subfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
PYH3_k127_8825333_4	273068.TTE1310	1.829e-43	164.0	COG0494@1|root,COG0494@2|Bacteria,1V6F5@1239|Firmicutes,24JFS@186801|Clostridia,42GHZ@68295|Thermoanaerobacterales	186801|Clostridia	L	PFAM NUDIX hydrolase	nudF	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS05505	NUDIX
PYH3_k127_8844070_16	1459636.NTE_00865	3.02e-12	68.0	COG0306@1|root,arCOG02267@2157|Archaea,41SD8@651137|Thaumarchaeota	651137|Thaumarchaeota	P	Phosphate transporter family	-	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
PYH3_k127_8844070_2	795359.TOPB45_1251	1.53e-172	553.0	COG1350@1|root,COG1350@2|Bacteria,2GHCP@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	-	-	4.2.1.20	ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
PYH3_k127_8844070_7	868131.MSWAN_0589	1.02e-38	151.0	COG2150@1|root,arCOG02316@2157|Archaea,2XWH9@28890|Euryarchaeota,23P42@183925|Methanobacteria	183925|Methanobacteria	K	regulator of amino acid metabolism, contains ACT domain	trpY	-	-	ko:K07103	-	-	-	-	ko00000	-	-	-	-
PYH3_k127_8844070_5	768706.Desor_0834	8.286e-50	184.0	COG0778@1|root,COG0778@2|Bacteria,1V9PC@1239|Firmicutes,24M6A@186801|Clostridia,266UE@186807|Peptococcaceae	186801|Clostridia	C	PFAM Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
PYH3_k127_8844070_8	903814.ELI_3642	1.646e-38	153.0	COG2122@1|root,COG2122@2|Bacteria,1TQ6A@1239|Firmicutes,249KT@186801|Clostridia,25YHZ@186806|Eubacteriaceae	186801|Clostridia	S	PFAM ApbE family	-	-	-	ko:K09740	-	-	-	-	ko00000	-	-	-	-
PYH3_k127_8844070_14	224325.AF_1185	2.073e-27	116.0	COG1145@1|root,arCOG02460@2157|Archaea,2Y0N6@28890|Euryarchaeota,246EW@183980|Archaeoglobi	183980|Archaeoglobi	C	4Fe-4S ferredoxin iron-sulfur binding	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,NIL
PYH3_k127_8844070_1	1041930.Mtc_0355	1.197e-180	578.0	COG1900@1|root,arCOG00620@2157|Archaea,2XVEU@28890|Euryarchaeota,2N93A@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,HcyBio
PYH3_k127_8844070_17	178306.PAE0463	9.967e-10	69.0	arCOG07689@1|root,arCOG07689@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_8844070_3	1041930.Mtc_0466	5.32e-69	252.0	COG0329@1|root,arCOG04172@2157|Archaea,2XSZX@28890|Euryarchaeota,2N99W@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
PYH3_k127_8844070_12	1365176.N186_05735	9.971e-32	129.0	COG2164@1|root,arCOG04488@2157|Archaea	2157|Archaea	S	Cyclophilin-like	-	-	-	ko:K09143	-	-	-	-	ko00000	-	-	-	Cyclophil_like
PYH3_k127_8844070_6	304371.MCP_0763	2.03e-44	172.0	COG0110@1|root,arCOG01848@2157|Archaea,2XWJM@28890|Euryarchaeota,2N98J@224756|Methanomicrobia	224756|Methanomicrobia	S	transferase hexapeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep,Hexapep_2
PYH3_k127_8844070_18	556268.OFAG_00423	1.622e-05	51.0	COG1977@1|root,COG1977@2|Bacteria,1N0IE@1224|Proteobacteria,2VVSP@28216|Betaproteobacteria,474XC@75682|Oxalobacteraceae	28216|Betaproteobacteria	H	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin	moaD	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
PYH3_k127_8844070_11	406552.NJ7G_3071	8.808e-33	135.0	COG0613@1|root,arCOG00302@2157|Archaea,2XSWE@28890|Euryarchaeota,23TEN@183963|Halobacteria	183963|Halobacteria	S	metal-dependent phosphoesterases (PHP family)	-	-	-	-	-	-	-	-	-	-	-	-	PHP,PHP_C
PYH3_k127_8844070_0	694429.Pyrfu_0888	3.718e-214	678.0	COG0143@1|root,arCOG00810@2157|Archaea,2XPMW@28889|Crenarchaeota	28889|Crenarchaeota	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g
PYH3_k127_8844070_10	386456.JQKN01000002_gene2878	6.042e-34	136.0	COG1601@1|root,arCOG01640@2157|Archaea,2XTVZ@28890|Euryarchaeota,23P0P@183925|Methanobacteria	183925|Methanobacteria	J	eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA	eif2b	-	-	ko:K03238	ko03013,map03013	-	-	-	ko00000,ko00001,ko01009,ko03012	-	-	-	eIF-5_eIF-2B
PYH3_k127_8844070_15	224325.AF_2325	1.09e-17	85.0	COG2412@1|root,arCOG04051@2157|Archaea,2XYQK@28890|Euryarchaeota,246CS@183980|Archaeoglobi	183980|Archaeoglobi	S	Protein of unknown function (DUF424)	-	-	-	ko:K09148	-	-	-	-	ko00000	-	-	-	DUF424
PYH3_k127_8844070_13	1131266.ARWQ01000005_gene783	1.372e-28	117.0	COG0361@1|root,arCOG01179@2157|Archaea,41SRK@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits	-	-	-	ko:K03236	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	eIF-1a
PYH3_k127_8844070_4	453591.Igni_0675	2.4e-64	229.0	COG1718@1|root,arCOG01180@2157|Archaea,2XPTK@28889|Crenarchaeota	28889|Crenarchaeota	T	Serine threonine protein kinase	-	-	2.7.11.1	ko:K07178	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko01001,ko03009	-	-	-	RIO1
PYH3_k127_8844070_9	419665.Maeo_0593	5.102e-35	138.0	COG1094@1|root,arCOG04150@2157|Archaea,2XUHX@28890|Euryarchaeota,23QSQ@183939|Methanococci	183939|Methanococci	J	SMART KH domain protein	-	-	-	ko:K06961	-	-	-	-	ko00000,ko03009	-	-	-	KH_1
PYH3_k127_8872184_1	391623.TERMP_01864	4.3e-17	95.0	COG0419@1|root,arCOG00368@2157|Archaea,2XTC7@28890|Euryarchaeota,244YZ@183968|Thermococci	183968|Thermococci	L	Rad50 zinc hook motif	-	-	-	ko:K03546	-	-	-	-	ko00000,ko03400	-	-	-	AAA_21,Rad50_zn_hook
PYH3_k127_8872184_0	555079.Toce_0030	1.409e-44	169.0	COG0535@1|root,COG0535@2|Bacteria,1V3MC@1239|Firmicutes,24I1P@186801|Clostridia,42J5X@68295|Thermoanaerobacterales	186801|Clostridia	S	Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_14,Radical_SAM
PYH3_k127_8888917_0	1365176.N186_01615	4.092e-38	151.0	COG1801@1|root,arCOG04291@2157|Archaea	2157|Archaea	L	DUF72 domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
PYH3_k127_8888917_1	926569.ANT_26680	1.391e-36	151.0	COG0725@1|root,COG0725@2|Bacteria,2G6J6@200795|Chloroflexi	200795|Chloroflexi	P	Molybdenum ABC transporter, periplasmic molybdate-binding protein	modA	-	-	ko:K02020	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	SBP_bac_11
PYH3_k127_8898535_2	309801.trd_A0900	8.033e-89	299.0	COG1060@1|root,COG1060@2|Bacteria,2G7YI@200795|Chloroflexi,27YSR@189775|Thermomicrobia	189775|Thermomicrobia	H	Elongator protein 3, MiaB family, Radical SAM	-	-	2.5.1.77	ko:K11779	ko00680,ko01120,map00680,map01120	M00378	R09396	RC01381,RC03002,RC03007	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
PYH3_k127_8898535_0	1382356.JQMP01000001_gene1157	2.732e-138	450.0	COG1060@1|root,COG1060@2|Bacteria,2GBD4@200795|Chloroflexi,27YV4@189775|Thermomicrobia	189775|Thermomicrobia	H	Elongator protein 3, MiaB family, Radical SAM	-	-	2.5.1.77	ko:K11779	ko00680,ko01120,map00680,map01120	M00378	R09396	RC01381,RC03002,RC03007	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
PYH3_k127_8898535_1	498761.HM1_2374	6.491e-111	370.0	COG0513@1|root,COG0513@2|Bacteria,1TPAP@1239|Firmicutes,247IT@186801|Clostridia	186801|Clostridia	L	Belongs to the DEAD box helicase family	cshA	-	3.6.4.13	ko:K05592	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,DbpA,Helicase_C
PYH3_k127_8898535_8	267377.MMP1032	3.769e-06	57.0	COG1599@1|root,arCOG01510@2157|Archaea,2XTJP@28890|Euryarchaeota,23Q10@183939|Methanococci	183939|Methanococci	L	PFAM nucleic acid binding, OB-fold, tRNA helicase-type	rpa	-	-	ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko03000,ko03032,ko03400	-	-	-	Rep_fac-A_C,tRNA_anti-codon
PYH3_k127_8898535_5	1041930.Mtc_1091	3.026e-19	87.0	arCOG03272@1|root,arCOG03272@2157|Archaea,2Y1VM@28890|Euryarchaeota,2NA39@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	2.7.7.6	ko:K00960	-	-	-	-	ko00000,ko01000	-	-	-	-
PYH3_k127_8898535_4	1313421.JHBV01000005_gene4566	2.573e-50	191.0	COG0451@1|root,COG0451@2|Bacteria,4NE3U@976|Bacteroidetes,1IQ61@117747|Sphingobacteriia	976|Bacteroidetes	M	PFAM NAD dependent epimerase dehydratase family	tdh	-	-	-	-	-	-	-	-	-	-	-	Epimerase
PYH3_k127_8898535_6	351160.RCIX2657	1.39e-15	87.0	COG1575@1|root,arCOG00480@2157|Archaea,2XXM6@28890|Euryarchaeota	28890|Euryarchaeota	H	PFAM UbiA prenyltransferase	-	-	2.5.1.74	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R05617,R06858,R10757	RC02935,RC02936,RC03264	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
PYH3_k127_8898535_3	391625.PPSIR1_26958	1.865e-51	194.0	COG0451@1|root,COG0451@2|Bacteria,1MU1A@1224|Proteobacteria,42RJF@68525|delta/epsilon subdivisions,2WNGK@28221|Deltaproteobacteria,2Z0BU@29|Myxococcales	28221|Deltaproteobacteria	GM	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
PYH3_k127_8898535_7	1121898.Q766_18335	5.173e-14	75.0	COG0467@1|root,COG0467@2|Bacteria,4NKD2@976|Bacteroidetes,1I7AB@117743|Flavobacteriia,2NV2J@237|Flavobacterium	976|Bacteroidetes	T	KaiC	-	-	-	ko:K08482	-	-	-	-	ko00000	-	-	-	ATPase
PYH3_k127_9016555_2	591019.Shell_1647	1.016e-68	238.0	COG0052@1|root,arCOG04245@2157|Archaea,2XPP9@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the universal ribosomal protein uS2 family	rps2	GO:0000028,GO:0000447,GO:0000460,GO:0000461,GO:0000462,GO:0000466,GO:0000469,GO:0000478,GO:0000479,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0031123,GO:0031125,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043628,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
PYH3_k127_9016555_0	694429.Pyrfu_0913	7.727e-86	292.0	COG1355@1|root,arCOG01728@2157|Archaea,2XPQS@28889|Crenarchaeota	28889|Crenarchaeota	S	Belongs to the MEMO1 family	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0032886,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0065007	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
PYH3_k127_9016555_3	1365176.N186_05790	7.846e-53	199.0	COG1577@1|root,arCOG01028@2157|Archaea,2XQ8U@28889|Crenarchaeota	28889|Crenarchaeota	F	Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids	mvk	GO:0003674,GO:0003824,GO:0004496,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006084,GO:0006139,GO:0006163,GO:0006629,GO:0006637,GO:0006644,GO:0006720,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008202,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009117,GO:0009150,GO:0009240,GO:0009259,GO:0009987,GO:0016125,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019287,GO:0019637,GO:0019693,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046490,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901135,GO:1901360,GO:1901564,GO:1901576,GO:1901615	2.7.1.36	ko:K00869	ko00900,ko01100,ko01110,ko01130,ko04146,map00900,map01100,map01110,map01130,map04146	M00095	R02245	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg
PYH3_k127_9016555_1	868131.MSWAN_1425	4.023e-82	282.0	COG1304@1|root,arCOG00613@2157|Archaea,2XT6H@28890|Euryarchaeota,23NQE@183925|Methanobacteria	183925|Methanobacteria	H	Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)	fni	-	5.3.3.2	ko:K01823	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00095,M00096,M00364,M00365,M00366,M00367	R01123	RC00455	ko00000,ko00001,ko00002,ko01000	-	-	-	FMN_dh
PYH3_k127_9093039_6	224325.AF_0356	1.821e-05	46.0	COG0524@1|root,arCOG00014@2157|Archaea,2XU7Z@28890|Euryarchaeota,245UH@183980|Archaeoglobi	183980|Archaeoglobi	G	Belongs to the carbohydrate kinase PfkB family	-	-	2.7.1.15	ko:K00852	ko00030,map00030	-	R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
PYH3_k127_9093039_2	436114.SYO3AOP1_1258	1.683e-71	246.0	COG0605@1|root,COG0605@2|Bacteria,2G4HC@200783|Aquificae	200783|Aquificae	C	radicals which are normally produced within the cells and which are toxic to biological systems	sodA	-	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
PYH3_k127_9093039_5	386456.JQKN01000007_gene3350	2.729e-13	74.0	COG1436@1|root,arCOG04102@2157|Archaea,2Y1TB@28890|Euryarchaeota,23P7Q@183925|Methanobacteria	183925|Methanobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	ahaF	-	-	ko:K02122	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_F
PYH3_k127_9093039_3	1041930.Mtc_0455	2.303e-48	177.0	COG1781@1|root,arCOG04229@2157|Archaea,2XWP4@28890|Euryarchaeota,2N9RS@224756|Methanomicrobia	224756|Methanomicrobia	F	Involved in allosteric regulation of aspartate carbamoyltransferase	pyrI	-	-	ko:K00610	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002	-	-	-	PyrI,PyrI_C
PYH3_k127_9093039_0	665571.STHERM_c07830	6.047e-146	471.0	COG2021@1|root,COG2021@2|Bacteria,2JA6P@203691|Spirochaetes	203691|Spirochaetes	E	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine	metXA	-	2.3.1.31	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	-	R01776	RC00004,RC00041	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
PYH3_k127_9093039_1	529709.PYCH_07500	7.592e-110	363.0	COG0540@1|root,arCOG00911@2157|Archaea,2XSZ7@28890|Euryarchaeota,242WA@183968|Thermococci	183968|Thermococci	F	Aspartate carbamoyltransferase	pyrB	GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
PYH3_k127_9093039_4	877455.Metbo_2531	1.792e-45	178.0	COG1328@1|root,COG2074@1|root,arCOG03714@1|root,arCOG01967@2157|Archaea,arCOG03714@2157|Archaea,arCOG04889@2157|Archaea,2XT2S@28890|Euryarchaeota,23NKA@183925|Methanobacteria	183925|Methanobacteria	F	Ribonucleoside-triphosphate reductase	nrdD	-	1.1.98.6	ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R11633,R11634,R11635,R11636	RC00613	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-cone,NRDD
PYH3_k127_9167929_23	292459.STH1872	2.407e-49	180.0	COG0156@1|root,COG0156@2|Bacteria,1TPUX@1239|Firmicutes,2491D@186801|Clostridia	186801|Clostridia	H	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide	kbl	GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008710,GO:0008890,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.3.1.29	ko:K00639	ko00260,map00260	-	R00371	RC00004,RC00394	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
PYH3_k127_9167929_35	269799.Gmet_3184	3.51e-27	114.0	2EU5A@1|root,33MMY@2|Bacteria,1NE4I@1224|Proteobacteria,42WER@68525|delta/epsilon subdivisions,2WRAE@28221|Deltaproteobacteria,43VD3@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Nitrous oxide-stimulated promoter	-	-	-	-	-	-	-	-	-	-	-	-	YgbA_NO
PYH3_k127_9167929_0	589924.Ferp_1340	2.614e-277	859.0	COG3256@1|root,arCOG04703@2157|Archaea,2XU3H@28890|Euryarchaeota	28890|Euryarchaeota	P	COG3256 Nitric oxide reductase large subunit	norB	-	1.7.2.5	ko:K04561	ko00910,ko01120,map00910,map01120	M00529	R00294	RC02794	ko00000,ko00001,ko00002,ko01000	3.D.4.10	-	-	COX1
PYH3_k127_9167929_14	589924.Ferp_1339	5.641e-85	291.0	COG0109@1|root,arCOG00479@2157|Archaea,2XUEM@28890|Euryarchaeota,247C6@183980|Archaeoglobi	183980|Archaeoglobi	H	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	ctaB	-	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
PYH3_k127_9167929_26	589924.Ferp_1683	9.644e-44	176.0	COG0683@1|root,arCOG01020@2157|Archaea,2XVWV@28890|Euryarchaeota,245XV@183980|Archaeoglobi	183980|Archaeoglobi	E	Periplasmic binding protein domain	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
PYH3_k127_9167929_7	304371.MCP_1481	1.343e-110	364.0	28M2T@1|root,2N55N@2157|Archaea,2Y31V@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_9167929_32	1041930.Mtc_1553	1.368e-32	137.0	COG2968@1|root,arCOG04715@2157|Archaea,2XZAZ@28890|Euryarchaeota,2N9TF@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF541)	-	-	-	ko:K09807	-	-	-	-	ko00000	-	-	-	SIMPL
PYH3_k127_9167929_19	1094980.Mpsy_2824	7.839e-73	274.0	COG0784@1|root,COG2202@1|root,COG2203@1|root,arCOG02349@1|root,arCOG02352@1|root,arCOG02376@1|root,arCOG04001@1|root,arCOG02349@2157|Archaea,arCOG02352@2157|Archaea,arCOG02357@2157|Archaea,arCOG02376@2157|Archaea,arCOG02391@2157|Archaea,arCOG02591@2157|Archaea,arCOG04001@2157|Archaea,arCOG06918@2157|Archaea,2Y82D@28890|Euryarchaeota,2NBNN@224756|Methanomicrobia	2157|Archaea	T	Histidine Phosphotransfer domain	-	-	-	ko:K03413,ko:K07662,ko:K07667,ko:K11443	ko01503,ko02020,ko02024,ko02030,ko04112,map01503,map02020,map02024,map02030,map04112	M00447,M00454,M00506,M00511,M00727,M00728	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	GAF_2,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
PYH3_k127_9167929_34	543632.JOJL01000020_gene528	2.561e-28	116.0	COG3324@1|root,COG3324@2|Bacteria,2IRXF@201174|Actinobacteria,4DEWK@85008|Micromonosporales	201174|Actinobacteria	S	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	Glyoxalase
PYH3_k127_9167929_3	374847.Kcr_0911	3.086e-201	641.0	COG0129@1|root,arCOG04045@2157|Archaea	2157|Archaea	H	Belongs to the IlvD Edd family	ilvD	GO:0003674,GO:0003824,GO:0004160,GO:0016829,GO:0016835,GO:0016836	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
PYH3_k127_9167929_20	1163730.FFONT_0663	1.294e-67	239.0	COG5014@1|root,arCOG05120@2157|Archaea,2XPWW@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM
PYH3_k127_9167929_44	926569.ANT_15990	3.138e-06	50.0	COG0550@1|root,COG0550@2|Bacteria,2G5ZR@200795|Chloroflexi	200795|Chloroflexi	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,zf-C4_Topoisom
PYH3_k127_9167929_41	985053.VMUT_1519	1.908e-13	75.0	COG1917@1|root,arCOG02999@2157|Archaea	2157|Archaea	S	conserved protein, contains double-stranded beta-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
PYH3_k127_9167929_28	565033.GACE_1086	4.554e-38	147.0	COG0822@1|root,arCOG02077@2157|Archaea,2XX32@28890|Euryarchaeota,2467Y@183980|Archaeoglobi	183980|Archaeoglobi	C	NifU-like N terminal domain	-	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
PYH3_k127_9167929_45	1380347.JNII01000007_gene681	1.351e-05	55.0	COG2314@1|root,COG2314@2|Bacteria	2|Bacteria	J	TM2 domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF2510,DUF4190,DUF4352
PYH3_k127_9167929_36	351160.LRC349	5.248e-26	113.0	COG3467@1|root,arCOG00520@2157|Archaea,2XXWD@28890|Euryarchaeota,2NAW4@224756|Methanomicrobia	224756|Methanomicrobia	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Pyridox_ox_2
PYH3_k127_9167929_4	37659.JNLN01000001_gene1543	7.556e-180	574.0	COG0415@1|root,COG0415@2|Bacteria,1UDZT@1239|Firmicutes,249FJ@186801|Clostridia,36FVA@31979|Clostridiaceae	186801|Clostridia	L	DNA photolyase	phr	-	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase
PYH3_k127_9167929_6	386456.JQKN01000002_gene2765	2.501e-115	380.0	COG1683@1|root,arCOG04848@2157|Archaea,2XV91@28890|Euryarchaeota	28890|Euryarchaeota	S	Protein of unknown function (DUF1722)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1722,DUF523
PYH3_k127_9167929_27	999630.TUZN_0370	9.62e-43	162.0	COG0500@1|root,arCOG01631@2157|Archaea,2XQ7P@28889|Crenarchaeota	28889|Crenarchaeota	Q	RNA methylase	-	GO:0003674,GO:0003824,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016278,GO:0016279,GO:0016740,GO:0016741,GO:0018022,GO:0018193,GO:0018205,GO:0019538,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:0140096,GO:1901564	-	-	-	-	-	-	-	-	-	-	CMAS,DOT1,Methyltransf_25,Methyltransf_31,PrmA
PYH3_k127_9167929_15	1459636.NTE_00077	2.512e-81	284.0	COG0476@1|root,COG1977@1|root,arCOG00536@2157|Archaea,arCOG01676@2157|Archaea,41S5X@651137|Thaumarchaeota	651137|Thaumarchaeota	H	ThiF family	-	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF,ThiS
PYH3_k127_9167929_9	1122216.AUHW01000001_gene726	7.003e-105	356.0	COG2271@1|root,COG2271@2|Bacteria,1UHSG@1239|Firmicutes,4H22F@909932|Negativicutes	909932|Negativicutes	G	Transporter, major facilitator family protein	naiP	-	-	ko:K08369	-	-	-	-	ko00000,ko02000	2.A.1	-	-	MFS_1,MFS_4,Sugar_tr
PYH3_k127_9167929_42	374847.Kcr_0944	2.04e-12	76.0	arCOG02103@1|root,arCOG02103@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4443
PYH3_k127_9167929_8	574087.Acear_0770	6.449e-108	364.0	COG1120@1|root,COG1120@2|Bacteria,1TP2Q@1239|Firmicutes,2492Z@186801|Clostridia,3WAET@53433|Halanaerobiales	186801|Clostridia	HP	PFAM ABC transporter	-	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
PYH3_k127_9167929_11	574087.Acear_0769	4.006e-95	323.0	COG0609@1|root,COG0609@2|Bacteria,1TPX6@1239|Firmicutes,248IS@186801|Clostridia,3WAHZ@53433|Halanaerobiales	186801|Clostridia	P	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily	-	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
PYH3_k127_9167929_17	868131.MSWAN_0360	5.053e-74	263.0	COG3635@1|root,arCOG01696@2157|Archaea,2XTE8@28890|Euryarchaeota,23NX3@183925|Methanobacteria	183925|Methanobacteria	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	apgM	-	5.4.2.12	ko:K15635	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,PhosphMutase
PYH3_k127_9167929_16	635013.TherJR_1312	2.625e-78	276.0	COG0079@1|root,COG0079@2|Bacteria,1TP5D@1239|Firmicutes,248Q0@186801|Clostridia,260RS@186807|Peptococcaceae	186801|Clostridia	E	PFAM Aminotransferase class I and II	-	-	4.1.1.81	ko:K04720	ko00860,map00860	-	R06530	RC00517	ko00000,ko00001,ko01000	-	-	-	Aminotran_1_2
PYH3_k127_9167929_21	1131266.ARWQ01000009_gene957	4.557e-63	228.0	COG1270@1|root,arCOG04274@2157|Archaea,41S6I@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group	cobD	-	6.3.1.10	ko:K02227	ko00860,ko01100,map00860,map01100	M00122	R06529,R07302	RC00090,RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	CobD_Cbib
PYH3_k127_9167929_13	572478.Vdis_0591	1.036e-89	311.0	COG2038@1|root,arCOG04272@2157|Archaea,2XQ64@28889|Crenarchaeota	28889|Crenarchaeota	H	Belongs to the UPF0284 family	-	-	-	-	-	-	-	-	-	-	-	-	DBI_PRT
PYH3_k127_9167929_38	1423321.AS29_20980	1.755e-17	94.0	COG1120@1|root,COG1120@2|Bacteria,1TP2Q@1239|Firmicutes,4HA28@91061|Bacilli,1ZASR@1386|Bacillus	91061|Bacilli	HP	COG1120 ABC-type cobalamin Fe3 -siderophores transport systems, ATPase components	yvrA	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran,CbiZ
PYH3_k127_9167929_33	269797.Mbar_A3455	6.924e-30	132.0	COG1267@1|root,arCOG01869@2157|Archaea,2XZTX@28890|Euryarchaeota,2NA1N@224756|Methanomicrobia	224756|Methanomicrobia	I	PFAM Phosphatidylglycerophosphatase A	-	-	-	-	-	-	-	-	-	-	-	-	PgpA
PYH3_k127_9167929_31	1220534.B655_0041	9.803e-33	136.0	COG0368@1|root,arCOG04338@2157|Archaea,2XU3T@28890|Euryarchaeota,23P3E@183925|Methanobacteria	183925|Methanobacteria	H	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate	cobS	-	2.7.8.26	ko:K02233	ko00860,ko01100,map00860,map01100	M00122	R05223,R11174	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CobS
PYH3_k127_9167929_29	386456.JQKN01000013_gene3046	3.305e-34	139.0	COG2266@1|root,arCOG01871@2157|Archaea,2XZP4@28890|Euryarchaeota,23P5D@183925|Methanobacteria	183925|Methanobacteria	M	Cytidylyltransferase	cobY	-	2.7.7.62	ko:K19712	ko00860,ko01100,map00860,map01100	-	R05222	RC00002	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
PYH3_k127_9167929_46	386456.JQKN01000008_gene1353	0.0002464	51.0	COG0457@1|root,COG1266@1|root,arCOG02769@2157|Archaea,arCOG03045@2157|Archaea,2XYZF@28890|Euryarchaeota	28890|Euryarchaeota	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi,TPR_12
PYH3_k127_9167929_1	439481.Aboo_1160	4.516e-250	790.0	COG0209@1|root,arCOG03713@1|root,arCOG03713@2157|Archaea,arCOG04276@2157|Archaea,2XUBW@28890|Euryarchaeota,3F2JF@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdJ	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	ATP-cone,Intein_splicing,LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN
PYH3_k127_9167929_10	693661.Arcve_2086	4.867e-96	326.0	COG0079@1|root,arCOG04273@2157|Archaea,2XTFZ@28890|Euryarchaeota,24602@183980|Archaeoglobi	183980|Archaeoglobi	E	Imidazole acetol-phosphate transaminase	-	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
PYH3_k127_9167929_30	589924.Ferp_1663	5.498e-33	130.0	arCOG10225@1|root,arCOG10225@2157|Archaea,2XZRF@28890|Euryarchaeota,246F4@183980|Archaeoglobi	183980|Archaeoglobi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_9167929_2	693661.Arcve_1684	5.682e-228	714.0	COG0174@1|root,arCOG01909@2157|Archaea,2XSYS@28890|Euryarchaeota,245NJ@183980|Archaeoglobi	183980|Archaeoglobi	E	glutamine synthetase	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
PYH3_k127_9167929_24	1459636.NTE_02630	3.112e-46	171.0	COG1522@1|root,arCOG01580@2157|Archaea,41T4E@651137|Thaumarchaeota	651137|Thaumarchaeota	K	helix_turn_helix ASNC type	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
PYH3_k127_9167929_25	1041930.Mtc_1078	9.004e-44	175.0	COG0438@1|root,arCOG01410@2157|Archaea,2Y8CA@28890|Euryarchaeota,2NBP9@224756|Methanomicrobia	224756|Methanomicrobia	M	Glycosyl transferase 4-like	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
PYH3_k127_9167929_40	761193.Runsl_0031	5.28e-14	80.0	COG0463@1|root,COG0560@1|root,COG0463@2|Bacteria,COG0560@2|Bacteria,4NHAG@976|Bacteroidetes,47RYN@768503|Cytophagia	976|Bacteroidetes	EM	Putative Phosphatase	serB	-	3.1.3.3	ko:K01079	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R00582	RC00017	ko00000,ko00001,ko00002,ko01000,ko01009	-	-	-	ACT_6,HAD
PYH3_k127_9167929_37	221360.RS9917_03533	2.422e-24	117.0	COG1215@1|root,COG1215@2|Bacteria,1G3BH@1117|Cyanobacteria,1GZ24@1129|Synechococcus	1117|Cyanobacteria	M	COG0463 Glycosyltransferases involved in cell wall biogenesis	-	-	2.4.1.266	ko:K13693	-	-	-	-	ko00000,ko01000,ko01003	-	GT81	-	-
PYH3_k127_9167929_5	521011.Mpal_0789	1.947e-135	452.0	COG4907@1|root,arCOG03432@2157|Archaea,2XVA0@28890|Euryarchaeota,2NA0A@224756|Methanomicrobia	224756|Methanomicrobia	S	Predicted membrane protein (DUF2207)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2207
PYH3_k127_9167929_18	521011.Mpal_0788	5.306e-73	250.0	COG1704@1|root,arCOG04574@2157|Archaea,2XX6E@28890|Euryarchaeota,2N9YK@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM LemA family	-	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
PYH3_k127_9167929_22	268739.Nmlp_2863	2.127e-55	209.0	COG2262@1|root,arCOG00353@2157|Archaea,2XT2W@28890|Euryarchaeota,23SNU@183963|Halobacteria	183963|Halobacteria	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
PYH3_k127_9167929_43	1459636.NTE_02126	1.682e-11	74.0	COG1599@1|root,arCOG01510@2157|Archaea,41SV1@651137|Thaumarchaeota	651137|Thaumarchaeota	L	COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins	-	-	-	ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko03000,ko03032,ko03400	-	-	-	tRNA_anti-codon
PYH3_k127_9167929_39	313606.M23134_01055	3.057e-16	80.0	COG1968@1|root,COG1968@2|Bacteria,4NGIZ@976|Bacteroidetes,47KGZ@768503|Cytophagia	976|Bacteroidetes	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
PYH3_k127_9290375_3	1499967.BAYZ01000160_gene411	1.299e-24	112.0	COG4948@1|root,COG4948@2|Bacteria,2NR7B@2323|unclassified Bacteria	2|Bacteria	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	ykfB	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016854,GO:0034641,GO:0043167,GO:0043169,GO:0043603,GO:0044237,GO:0046872,GO:0071704,GO:1901564	5.1.1.20	ko:K19802	-	-	R10938	RC03309	ko00000,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
PYH3_k127_9290375_2	523845.AQXV01000046_gene840	2.669e-64	235.0	COG0075@1|root,arCOG00082@2157|Archaea,2XTWU@28890|Euryarchaeota,23QRP@183939|Methanococci	183939|Methanococci	E	PFAM aminotransferase class V	-	GO:0001505,GO:0003674,GO:0003824,GO:0004760,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0006082,GO:0006520,GO:0006544,GO:0006545,GO:0006807,GO:0008150,GO:0008152,GO:0008453,GO:0008483,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0017144,GO:0019265,GO:0019752,GO:0042133,GO:0042136,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	-	-	-	-	-	-	-	-	-	-	Aminotran_5
PYH3_k127_9290375_1	247490.KSU1_D0929	5.704e-104	349.0	COG2132@1|root,COG2132@2|Bacteria	2|Bacteria	Q	Multicopper oxidase	nirK	-	1.7.2.1	ko:K00368	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000	-	-	-	Copper-bind,Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3,Cupredoxin_1,Cytochrom_C,Cytochrome_CBB3
PYH3_k127_9290375_0	1121439.dsat_1223	6.236e-119	385.0	COG0369@1|root,COG1151@2|Bacteria,1N88B@1224|Proteobacteria,42M2C@68525|delta/epsilon subdivisions,2WIVE@28221|Deltaproteobacteria,2M8MU@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O	hcp	-	1.7.99.1	ko:K05601	ko00910,map00910	-	R00143	RC02797	ko00000,ko00001,ko01000	-	-	-	Prismane
PYH3_k127_9421288_11	663610.JQKO01000006_gene2609	8.447e-25	106.0	COG0189@1|root,COG0189@2|Bacteria,1MX62@1224|Proteobacteria,2TRUH@28211|Alphaproteobacteria,3NAF4@45404|Beijerinckiaceae	28211|Alphaproteobacteria	HJ	RimK-like ATP-grasp domain	-	-	-	ko:K05844	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	RimK
PYH3_k127_9421288_9	1220534.B655_0325	6.342e-73	254.0	COG3640@1|root,arCOG00587@2157|Archaea,2XT61@28890|Euryarchaeota	28890|Euryarchaeota	D	PFAM Cobyrinic acid a,c-diamide synthase	-	-	-	ko:K07321	-	-	-	-	ko00000	-	-	-	CbiA
PYH3_k127_9421288_0	593750.Metfor_1719	7.011e-195	617.0	COG1614@1|root,arCOG04360@2157|Archaea,2XU0D@28890|Euryarchaeota,2N95I@224756|Methanomicrobia	224756|Methanomicrobia	C	Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex)	cdhC	-	-	ko:K00193	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00357,M00422	R09096,R10219	RC00004,RC00113,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhC
PYH3_k127_9421288_4	593750.Metfor_1718	4.791e-120	397.0	COG2069@1|root,arCOG01980@2157|Archaea,2XTXS@28890|Euryarchaeota,2N93F@224756|Methanomicrobia	224756|Methanomicrobia	C	Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing	cdhD	-	2.1.1.245	ko:K00194	ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200	M00357,M00377,M00422	R09096,R10219,R10243	RC00004,RC00113,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A0200	CdhD
PYH3_k127_9421288_1	593750.Metfor_1717	6.932e-172	553.0	COG1456@1|root,arCOG01979@2157|Archaea,2XUSG@28890|Euryarchaeota,2N9BD@224756|Methanomicrobia	224756|Methanomicrobia	C	Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing	cdhE	-	2.1.1.245	ko:K00197	ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200	M00357,M00377,M00422	R09096,R10219,R10243	RC00004,RC00113,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhD,FeS
PYH3_k127_9421288_3	1229909.NSED_07320	9.942e-123	410.0	COG3569@1|root,arCOG08649@2157|Archaea,41SDH@651137|Thaumarchaeota	651137|Thaumarchaeota	L	DNA Topoisomerase I (eukaryota)	-	-	5.99.1.2	ko:K03163	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	Topo_C_assoc,Topoisom_I,Topoisom_I_N
PYH3_k127_9421288_12	1121035.AUCH01000012_gene3023	7.635e-24	112.0	COG0501@1|root,COG0501@2|Bacteria,1NG7Y@1224|Proteobacteria	1224|Proteobacteria	E	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
PYH3_k127_9421288_7	1268072.PSAB_13605	6.078e-83	286.0	COG3246@1|root,COG3246@2|Bacteria,1TQNV@1239|Firmicutes,4HASC@91061|Bacilli,270SS@186822|Paenibacillaceae	91061|Bacilli	S	beta-keto acid cleavage enzyme	-	-	2.3.1.247	ko:K18013	ko00310,map00310	-	R10564	RC02728,RC03199	ko00000,ko00001,ko01000	-	-	-	BKACE
PYH3_k127_9421288_5	368407.Memar_0659	1.322e-107	357.0	COG1131@1|root,arCOG00194@2157|Archaea,2XUK9@28890|Euryarchaeota,2N9HU@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM ABC transporter related	-	-	-	ko:K09695	ko02010,map02010	M00252	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.102	-	-	ABC_tran
PYH3_k127_9421288_6	1094980.Mpsy_1950	5.678e-95	317.0	COG0842@1|root,arCOG01463@2157|Archaea,2XXQI@28890|Euryarchaeota,2N9MG@224756|Methanomicrobia	224756|Methanomicrobia	P	PFAM ABC-2 type transporter	-	-	-	ko:K09694	ko02010,map02010	M00252	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.102	-	-	ABC2_membrane
PYH3_k127_9421288_8	1268072.PSAB_13605	6.002e-79	277.0	COG3246@1|root,COG3246@2|Bacteria,1TQNV@1239|Firmicutes,4HASC@91061|Bacilli,270SS@186822|Paenibacillaceae	91061|Bacilli	S	beta-keto acid cleavage enzyme	-	-	2.3.1.247	ko:K18013	ko00310,map00310	-	R10564	RC02728,RC03199	ko00000,ko00001,ko01000	-	-	-	BKACE
PYH3_k127_9421288_10	332101.JIBU02000004_gene85	2.603e-25	115.0	COG1073@1|root,COG1073@2|Bacteria,1V84C@1239|Firmicutes,24MJG@186801|Clostridia,36Q2H@31979|Clostridiaceae	186801|Clostridia	S	Prolyl oligopeptidase family	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4,Peptidase_S9
PYH3_k127_9421288_2	368408.Tpen_0750	8.777e-141	457.0	COG1793@1|root,arCOG01347@2157|Archaea,2XPV8@28889|Crenarchaeota	28889|Crenarchaeota	L	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair	lig	GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016874,GO:0016886,GO:0022616,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360,GO:1901576	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N
PYH3_k127_9458046_12	1123073.KB899245_gene96	2.855e-19	103.0	COG1361@1|root,COG3210@1|root,COG4733@1|root,COG5272@1|root,COG1361@2|Bacteria,COG3210@2|Bacteria,COG4733@2|Bacteria,COG5272@2|Bacteria	2|Bacteria	O	ubiquitin	-	-	-	ko:K02927,ko:K20276	ko02024,ko03010,map02024,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Autotransporter,Calx-beta,ubiquitin
PYH3_k127_9458046_14	868131.MSWAN_2069	3.081e-17	82.0	COG3269@1|root,arCOG01641@2157|Archaea,2Y1N9@28890|Euryarchaeota	28890|Euryarchaeota	S	PFAM Deoxyribonuclease rho motif-related TRAM	-	-	-	-	-	-	-	-	-	-	-	-	TRAM
PYH3_k127_9458046_9	694429.Pyrfu_0129	1.3e-43	165.0	COG1514@1|root,arCOG01736@2157|Archaea,2XQM6@28889|Crenarchaeota	28889|Crenarchaeota	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	ligT	-	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
PYH3_k127_9458046_10	529709.PYCH_09240	1.95e-43	165.0	COG0237@1|root,arCOG01045@2157|Archaea,2XWNJ@28890|Euryarchaeota,2433T@183968|Thermococci	183968|Thermococci	H	Belongs to the UPF0200 family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_17
PYH3_k127_9458046_16	444157.Tneu_0685	3.289e-12	72.0	COG1931@1|root,arCOG01043@2157|Archaea,2XQU6@28889|Crenarchaeota	28889|Crenarchaeota	S	Belongs to the UPF0201 family	-	-	-	ko:K09736	-	-	-	-	ko00000	-	-	-	RNA_binding
PYH3_k127_9458046_3	269797.Mbar_A1789	7.29e-80	277.0	COG1234@1|root,arCOG00501@2157|Archaea,2XTJ9@28890|Euryarchaeota,2N96S@224756|Methanomicrobia	224756|Methanomicrobia	J	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA	rnz	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
PYH3_k127_9458046_7	1220534.B655_0134	1.077e-50	194.0	COG1041@1|root,arCOG00047@2157|Archaea,2XTD6@28890|Euryarchaeota,23NJD@183925|Methanobacteria	183925|Methanobacteria	L	methylase	-	-	2.1.1.213	ko:K07446	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	THUMP,UPF0020
PYH3_k127_9458046_5	933801.Ahos_1245	1.89e-64	231.0	COG0462@1|root,arCOG00067@2157|Archaea,2XQE3@28889|Crenarchaeota	28889|Crenarchaeota	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran,Pribosyltran_N
PYH3_k127_9458046_15	1267533.KB906734_gene3891	3.857e-15	81.0	COG1714@1|root,COG1714@2|Bacteria	2|Bacteria	S	RDD family	-	-	-	-	-	-	-	-	-	-	-	-	RDD
PYH3_k127_9458046_2	391623.TERMP_00777	6.212e-89	306.0	COG1313@1|root,arCOG00934@2157|Archaea,2XUM6@28890|Euryarchaeota,242QN@183968|Thermococci	183968|Thermococci	O	4Fe-4S single cluster domain	-	-	1.97.1.4	ko:K04070	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
PYH3_k127_9458046_4	269797.Mbar_A0624	5.254e-71	255.0	COG0119@1|root,arCOG02093@2157|Archaea,2XVVR@28890|Euryarchaeota,2N9C3@224756|Methanomicrobia	224756|Methanomicrobia	E	HMGL-like	-	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
PYH3_k127_9458046_11	1459636.NTE_02630	1.516e-37	146.0	COG1522@1|root,arCOG01580@2157|Archaea,41T4E@651137|Thaumarchaeota	651137|Thaumarchaeota	K	helix_turn_helix ASNC type	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
PYH3_k127_9458046_0	857293.CAAU_1092	6.648e-170	548.0	COG0519@1|root,COG0519@2|Bacteria,1TPG8@1239|Firmicutes,2487F@186801|Clostridia,36EFK@31979|Clostridiaceae	186801|Clostridia	F	Catalyzes the synthesis of GMP from XMP	guaA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase,tRNA_Me_trans
PYH3_k127_9458046_6	338966.Ppro_0593	2.71e-56	201.0	COG3260@1|root,COG3260@2|Bacteria,1QUBE@1224|Proteobacteria,42NH3@68525|delta/epsilon subdivisions,2WNT3@28221|Deltaproteobacteria,43UYP@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	PFAM NADH ubiquinone oxidoreductase 20 kDa subunit	-	-	-	ko:K14088	-	-	-	-	ko00000	-	-	-	Oxidored_q6
PYH3_k127_9458046_13	593750.Metfor_0145	4.295e-19	93.0	COG0852@1|root,arCOG01551@2157|Archaea,2XZK1@28890|Euryarchaeota,2NA35@224756|Methanomicrobia	224756|Methanomicrobia	C	Respiratory-chain NADH dehydrogenase, 30 Kd subunit	-	-	1.5.98.3	ko:K22160	-	-	-	-	ko00000,ko01000	3.D.9.1	-	-	Complex1_30kDa
PYH3_k127_9458046_1	338966.Ppro_3524	7.654e-135	440.0	COG3261@1|root,COG3261@2|Bacteria,1QUBF@1224|Proteobacteria,43DST@68525|delta/epsilon subdivisions,2WJ4E@28221|Deltaproteobacteria,43TGG@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	PFAM NADH-ubiquinone oxidoreductase, chain 49kDa	-	-	1.6.5.3	ko:K00333,ko:K14090	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa,NiFeSe_Hases
PYH3_k127_9458046_8	258594.RPA4258	3.155e-46	178.0	COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,2U2YV@28211|Alphaproteobacteria,3K2ZV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH1	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
PYH3_k127_9753219_0	667014.Thein_1615	8.56e-155	498.0	COG1048@1|root,COG1048@2|Bacteria,2GH01@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	C	Aconitase family (aconitate hydratase)	-	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
PYH3_k127_9753219_3	933801.Ahos_0200	9.625e-56	198.0	COG1225@1|root,arCOG00310@2157|Archaea,2XQPI@28889|Crenarchaeota	28889|Crenarchaeota	O	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	bcp	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
PYH3_k127_9753219_2	431943.CKL_2501	7.774e-75	263.0	COG1606@1|root,COG1606@2|Bacteria,1TPB2@1239|Firmicutes,2485J@186801|Clostridia,36DE3@31979|Clostridiaceae	186801|Clostridia	S	TIGRFAM TIGR00268 family protein	-	-	-	ko:K06864	-	-	-	-	ko00000	-	-	-	ATP_bind_3,NAD_synthase,QueC
PYH3_k127_9753219_1	374847.Kcr_0479	2.489e-90	304.0	COG1691@1|root,arCOG02465@2157|Archaea	2157|Archaea	S	1-(5-Phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase	-	-	-	ko:K06898	-	-	-	-	ko00000	-	-	-	AIRC
PYH3_k127_9753219_4	368408.Tpen_1212	4.483e-52	191.0	COG5012@1|root,arCOG02028@2157|Archaea,2XRVB@28889|Crenarchaeota	28889|Crenarchaeota	S	Methionine synthase B12-binding module cap domain protein	-	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2
PYH3_k127_9753219_5	1499967.BAYZ01000050_gene2827	5.988e-05	53.0	COG0407@1|root,COG0407@2|Bacteria	2|Bacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
PYH3_k127_9775047_6	589924.Ferp_1128	3.554e-55	196.0	COG0136@1|root,arCOG00494@2157|Archaea,2XTKH@28890|Euryarchaeota,245UR@183980|Archaeoglobi	183980|Archaeoglobi	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
PYH3_k127_9775047_4	1220534.B655_1007	6.098e-82	289.0	COG0527@1|root,arCOG00861@2157|Archaea,2XTJ0@28890|Euryarchaeota,23NKX@183925|Methanobacteria	183925|Methanobacteria	E	Belongs to the aspartokinase family	ask	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT_7
PYH3_k127_9775047_1	246969.TAM4_485	1.459e-165	540.0	COG0449@1|root,arCOG00057@2157|Archaea,2XTC0@28890|Euryarchaeota,243IS@183968|Thermococci	183968|Thermococci	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	GO:0003674,GO:0003824,GO:0004360,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
PYH3_k127_9775047_3	485913.Krac_0981	3.541e-92	312.0	COG0391@1|root,COG0391@2|Bacteria,2G5S2@200795|Chloroflexi	200795|Chloroflexi	S	TIGRFAM LPPG domain protein containing protein	cofD	-	2.7.8.28	ko:K11212	ko00680,ko01120,map00680,map01120	M00378	R09398	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	UPF0052
PYH3_k127_9775047_11	1382306.JNIM01000001_gene1898	8.4e-20	97.0	COG1920@1|root,COG1920@2|Bacteria,2G76R@200795|Chloroflexi	200795|Chloroflexi	H	Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor	cofC	GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0043814,GO:0044237,GO:0044249,GO:0051186,GO:0051188,GO:0070568	2.7.7.68	ko:K14941	ko00680,ko01120,map00680,map01120	M00378	R09397	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CofC
PYH3_k127_9775047_2	1229909.NSED_07795	4.065e-124	406.0	COG0104@1|root,arCOG04387@2157|Archaea,41SCA@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
PYH3_k127_9775047_0	246194.CHY_0125	5.418e-194	619.0	COG0504@1|root,COG0504@2|Bacteria,1TP34@1239|Firmicutes,2482E@186801|Clostridia,42F21@68295|Thermoanaerobacterales	186801|Clostridia	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS01075	CTP_synth_N,GATase
PYH3_k127_9775047_8	768672.Desfe_0755	7.279e-32	134.0	COG4720@1|root,arCOG05752@2157|Archaea,2XQ9C@28889|Crenarchaeota	28889|Crenarchaeota	S	ECF-type riboflavin transporter, S component	-	-	-	-	-	-	-	-	-	-	-	-	ECF-ribofla_trS
PYH3_k127_9775047_5	694429.Pyrfu_0799	2.205e-69	245.0	COG0478@1|root,arCOG01181@2157|Archaea,2XPM0@28889|Crenarchaeota	28889|Crenarchaeota	T	RIO-like serine threonine protein kinase fused to N-terminal HTH domain	-	-	2.7.11.1	ko:K07179	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko01001,ko03009	-	-	-	RIO1,Rio2_N
PYH3_k127_9775047_14	1229909.NSED_00125	2.435e-13	72.0	COG1958@1|root,arCOG00998@2157|Archaea,41SS5@651137|Thaumarchaeota	651137|Thaumarchaeota	K	snRNP Sm proteins	-	-	-	ko:K04796	-	-	-	-	ko00000	-	-	-	LSM
PYH3_k127_9775047_7	415426.Hbut_1101	3.789e-53	196.0	COG1637@1|root,arCOG01304@2157|Archaea,2XQ7Z@28889|Crenarchaeota	28889|Crenarchaeota	L	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures	nucS	-	-	ko:K07503	-	-	-	-	ko00000,ko01000	-	-	-	NucS
PYH3_k127_9775047_12	633148.Tagg_1147	1.479e-16	88.0	COG1475@1|root,arCOG01875@2157|Archaea,2XR7V@28889|Crenarchaeota	28889|Crenarchaeota	K	PFAM ParB domain protein nuclease	-	-	-	-	-	-	-	-	-	-	-	-	ParBc
PYH3_k127_9775047_9	1459636.NTE_01393	1.211e-29	137.0	arCOG10172@1|root,arCOG10597@1|root,arCOG10172@2157|Archaea,arCOG10597@2157|Archaea,41TBJ@651137|Thaumarchaeota	2157|Archaea	O	serine-type endopeptidase activity	-	-	1.14.18.1,3.4.21.62	ko:K00505,ko:K01342,ko:K02035	ko00350,ko00950,ko00965,ko01100,ko01110,ko02024,ko04916,map00350,map00950,map00965,map01100,map01110,map02024,map04916	M00042,M00239	R00731,R02078,R02363,R02383,R04693,R04884	RC00046,RC00150,RC00180	ko00000,ko00001,ko00002,ko01000,ko01002,ko02000,ko03110	3.A.1.5	-	-	Peptidase_S8
PYH3_k127_9775047_13	1379270.AUXF01000003_gene3449	2.546e-14	86.0	COG1470@1|root,COG1470@2|Bacteria,1ZT2Y@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_983039_4	368408.Tpen_0341	1.31e-31	127.0	COG1156@1|root,arCOG00865@2157|Archaea,2XPKW@28889|Crenarchaeota	28889|Crenarchaeota	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit	atpB	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
PYH3_k127_983039_0	1343739.PAP_09425	1.64e-201	644.0	COG1155@1|root,arCOG00868@2157|Archaea,2XT8I@28890|Euryarchaeota,243AQ@183968|Thermococci	183968|Thermococci	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit	atpA	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0034220,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044464,GO:0044769,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132,GO:1902600	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn,Intein_splicing,LAGLIDADG_3
PYH3_k127_983039_10	5111.M1W558	0.0001505	51.0	COG1390@1|root,KOG1664@2759|Eukaryota,38FW0@33154|Opisthokonta,3NXSD@4751|Fungi,3QPPF@4890|Ascomycota,2139N@147550|Sordariomycetes,3TD6X@5125|Hypocreales,3FZPR@34397|Clavicipitaceae	4751|Fungi	C	ATP synthase (E/31 kDa) subunit	VMA4	GO:0000221,GO:0000322,GO:0000323,GO:0000324,GO:0000329,GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005773,GO:0005774,GO:0006810,GO:0006811,GO:0006812,GO:0006873,GO:0006885,GO:0007035,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015988,GO:0015991,GO:0016020,GO:0016021,GO:0016462,GO:0016469,GO:0016471,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019725,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030003,GO:0030004,GO:0030641,GO:0031090,GO:0031224,GO:0032991,GO:0033176,GO:0033178,GO:0033180,GO:0034220,GO:0036442,GO:0042592,GO:0042623,GO:0042625,GO:0042626,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043492,GO:0044422,GO:0044424,GO:0044425,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0044769,GO:0045851,GO:0046961,GO:0048878,GO:0050801,GO:0051179,GO:0051234,GO:0051452,GO:0051453,GO:0055067,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0090662,GO:0098588,GO:0098655,GO:0098660,GO:0098662,GO:0098771,GO:0098796,GO:0098805,GO:0098852,GO:0099131,GO:0099132,GO:1902600	-	ko:K02150	ko00190,ko01100,ko04145,ko04150,ko04721,ko04966,ko05110,ko05120,ko05323,map00190,map01100,map04145,map04150,map04721,map04966,map05110,map05120,map05323	M00160	-	-	ko00000,ko00001,ko00002	3.A.2.2	-	-	vATP-synt_E
PYH3_k127_983039_11	69014.TK1596	0.0001686	48.0	COG2811@1|root,arCOG03363@2157|Archaea,2Y4S2@28890|Euryarchaeota,245JU@183968|Thermococci	183968|Thermococci	C	H subunit	-	-	-	ko:K02107	ko00190,map00190	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V-ATPase_G_2
PYH3_k127_983039_9	596151.DesfrDRAFT_1708	7.867e-07	57.0	COG0589@1|root,COG0589@2|Bacteria,1RA7K@1224|Proteobacteria,42V2P@68525|delta/epsilon subdivisions,2WRFB@28221|Deltaproteobacteria,2MBG2@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	Universal stress protein	usp-2	-	-	ko:K06149	-	-	-	-	ko00000	-	-	-	Usp
PYH3_k127_983039_1	589924.Ferp_0178	1.092e-84	293.0	COG1250@1|root,arCOG00251@2157|Archaea,2Y3BN@28890|Euryarchaeota,246SW@183980|Archaeoglobi	183980|Archaeoglobi	I	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	3HCDH,3HCDH_N
PYH3_k127_983039_6	1499967.BAYZ01000139_gene119	8.024e-15	80.0	COG0346@1|root,COG0346@2|Bacteria,2NPRH@2323|unclassified Bacteria	2|Bacteria	E	Glyoxalase-like domain	mce	-	5.1.99.1	ko:K05606	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R02765,R09979	RC00780,RC02739	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase_4
PYH3_k127_983039_7	399550.Smar_0669	3.129e-10	65.0	arCOG12413@1|root,arCOG12413@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PYH3_k127_983039_2	316067.Geob_2830	5.956e-52	192.0	COG1402@1|root,COG1402@2|Bacteria,1MXR9@1224|Proteobacteria,42QNA@68525|delta/epsilon subdivisions,2WMNK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Creatinine amidohydrolase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
PYH3_k127_983039_3	574087.Acear_0240	1.674e-32	138.0	COG1145@1|root,COG2006@1|root,COG1145@2|Bacteria,COG2006@2|Bacteria,1TRX2@1239|Firmicutes,249GX@186801|Clostridia,3WAJ1@53433|Halanaerobiales	186801|Clostridia	C	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362,Fer4,Fer4_10,Fer4_7
PYH3_k127_983039_5	1034809.SLUG_14640	1.211e-26	123.0	COG0547@1|root,COG0547@2|Bacteria,1TP8U@1239|Firmicutes,4H9KQ@91061|Bacilli,4GY66@90964|Staphylococcaceae	91061|Bacilli	F	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0004425,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.18,4.1.3.27	ko:K00766,ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R00985,R00986,R01073	RC00010,RC00440,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
## 1465 queries scanned
## Total time (seconds): 26.05396294593811
## Rate: 56.23 q/s