## Mon Nov 11 21:33:48 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/4635/R/REGS1_bin.20.fa -m mmseqs --itype genome -o REGS1_bin.20 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/bins_4635/REGS1_bin.20 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
REGS1_k127_1015389_2	443143.GM18_2745	3.647e-90	303.0	COG3146@1|root,COG3146@2|Bacteria,1R5A3@1224|Proteobacteria,4317B@68525|delta/epsilon subdivisions,2WWUG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_6
REGS1_k127_1015389_0	443143.GM18_2744	5.016e-152	485.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,42MV1@68525|delta/epsilon subdivisions,2WM7T@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	ABC transporter	-	-	-	ko:K01990,ko:K09695	ko02010,map02010	M00252,M00254	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.102	-	-	ABC_tran,DUF4162
REGS1_k127_1015389_1	443143.GM18_2743	7.706e-150	480.0	COG0842@1|root,COG0842@2|Bacteria,1Q99P@1224|Proteobacteria,42M53@68525|delta/epsilon subdivisions,2WMEY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane,ABC2_membrane_3
REGS1_k127_102037_2	269799.Gmet_2035	7.02e-72	254.0	COG3852@1|root,COG3852@2|Bacteria,1NR54@1224|Proteobacteria,42YYW@68525|delta/epsilon subdivisions,2WU15@28221|Deltaproteobacteria,43TG5@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	2.7.13.3	ko:K07708	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c
REGS1_k127_102037_0	1123376.AUIU01000011_gene939	1.071e-191	617.0	COG0449@1|root,COG0449@2|Bacteria,3J0CP@40117|Nitrospirae	40117|Nitrospirae	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
REGS1_k127_102037_1	338963.Pcar_1805	4.598e-130	436.0	COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,42KZ7@68525|delta/epsilon subdivisions,2WJP6@28221|Deltaproteobacteria,43S1W@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	iAF987.Gmet_1487	GATase_6,SIS
REGS1_k127_102037_3	1230457.C476_13892	7.779e-12	66.0	COG2340@1|root,arCOG03962@2157|Archaea,2XT4K@28890|Euryarchaeota,23W0I@183963|Halobacteria	183963|Halobacteria	S	Cysteine-rich secretory protein family	-	-	-	-	-	-	-	-	-	-	-	-	CAP
REGS1_k127_1031570_1	580332.Slit_1327	1.898e-78	294.0	COG2203@1|root,COG3829@1|root,COG4251@1|root,COG2203@2|Bacteria,COG3829@2|Bacteria,COG4251@2|Bacteria,1RGKE@1224|Proteobacteria,2WHFM@28216|Betaproteobacteria,44WPK@713636|Nitrosomonadales	28216|Betaproteobacteria	T	SMART ATP-binding region ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_4
REGS1_k127_1031570_0	32057.KB217478_gene2230	2.446e-109	388.0	COG1352@1|root,COG2201@1|root,COG5002@1|root,COG1352@2|Bacteria,COG2201@2|Bacteria,COG5002@2|Bacteria,1GHEK@1117|Cyanobacteria	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	2.1.1.80,3.1.1.61	ko:K13924	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,CheR,CheR_N,HATPase_c,HisKA,PAS_10,PAS_4
REGS1_k127_1042732_0	690850.Desaf_1218	2.321e-280	882.0	COG1924@1|root,COG3580@1|root,COG3581@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,COG3581@2|Bacteria,1PKG6@1224|Proteobacteria,42MY4@68525|delta/epsilon subdivisions,2WJFI@28221|Deltaproteobacteria,2M8T9@213115|Desulfovibrionales	28221|Deltaproteobacteria	I	ATPase BadF BadG BcrA BcrD type	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,DUF2229
REGS1_k127_1081140_5	243231.GSU0083	1.066e-07	53.0	COG1496@1|root,COG1496@2|Bacteria,1MW2H@1224|Proteobacteria,42SE9@68525|delta/epsilon subdivisions,2WMQE@28221|Deltaproteobacteria,43TE9@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Multi-copper polyphenol oxidoreductase laccase	-	-	-	ko:K05810	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_4
REGS1_k127_1081140_2	589865.DaAHT2_0243	6.211e-39	150.0	COG0517@1|root,COG0517@2|Bacteria,1QUKQ@1224|Proteobacteria,42TPD@68525|delta/epsilon subdivisions,2WQQ5@28221|Deltaproteobacteria,2MK07@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
REGS1_k127_1081140_3	1121405.dsmv_0207	1.457e-25	111.0	COG0802@1|root,COG0802@2|Bacteria,1RGYU@1224|Proteobacteria,42VU4@68525|delta/epsilon subdivisions,2WQBA@28221|Deltaproteobacteria,2MKGC@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Threonylcarbamoyl adenosine biosynthesis protein TsaE	yjeE	-	-	ko:K06925	-	-	-	-	ko00000,ko03016	-	-	-	TsaE
REGS1_k127_1081140_0	671143.DAMO_0325	3.671e-96	322.0	COG0061@1|root,COG0061@2|Bacteria,2NP7T@2323|unclassified Bacteria	2|Bacteria	G	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	GO:0000166,GO:0003674,GO:0003824,GO:0003951,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006741,GO:0006753,GO:0006766,GO:0006767,GO:0006769,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008976,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009820,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016776,GO:0017076,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	iEcSMS35_1347.EcSMS35_2767,iHN637.CLJU_RS05480,iLJ478.TM1733,iSB619.SA_RS04895	NAD_kinase
REGS1_k127_1081140_1	1499967.BAYZ01000115_gene2921	1.023e-65	232.0	COG1573@1|root,COG1573@2|Bacteria,2NP99@2323|unclassified Bacteria	2|Bacteria	L	Uracil DNA glycosylase superfamily	ung	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
REGS1_k127_1081140_4	1121439.dsat_1583	4.645e-11	68.0	COG0760@1|root,COG0760@2|Bacteria,1MVB3@1224|Proteobacteria,42QXH@68525|delta/epsilon subdivisions,2WMN3@28221|Deltaproteobacteria,2M8YR@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	peptidylprolyl isomerase	surA	-	5.2.1.8	ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N,SurA_N_3
REGS1_k127_109269_2	1120966.AUBU01000008_gene2572	4.971e-33	133.0	COG4731@1|root,COG4731@2|Bacteria,4NQCK@976|Bacteroidetes,47R93@768503|Cytophagia	976|Bacteroidetes	S	Uncharacterized protein conserved in bacteria (DUF2147)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2147
REGS1_k127_109269_0	316067.Geob_2058	1.69e-102	340.0	COG0500@1|root,COG2226@2|Bacteria,1MXP4@1224|Proteobacteria	1224|Proteobacteria	Q	Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25,Methyltransf_31,Ubie_methyltran
REGS1_k127_109269_1	289376.THEYE_A0070	6.109e-82	277.0	COG0118@1|root,COG0118@2|Bacteria,3J0K7@40117|Nitrospirae	40117|Nitrospirae	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	-	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
REGS1_k127_1109267_1	589865.DaAHT2_2409	2.53e-60	216.0	COG1216@1|root,COG1216@2|Bacteria,1R13V@1224|Proteobacteria,43D64@68525|delta/epsilon subdivisions,2X8CV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
REGS1_k127_1109267_0	589865.DaAHT2_2410	1.161e-118	394.0	COG0535@1|root,COG0535@2|Bacteria,1RADC@1224|Proteobacteria,42RDA@68525|delta/epsilon subdivisions,2WN4I@28221|Deltaproteobacteria,2MM5N@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Iron-sulfur cluster-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_14,Radical_SAM,SPASM
REGS1_k127_1109267_2	1121403.AUCV01000038_gene4239	4.841e-15	87.0	COG1305@1|root,COG1305@2|Bacteria	2|Bacteria	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DUF3857,Transglut_core
REGS1_k127_1131736_4	398767.Glov_3082	9.564e-45	164.0	COG2038@1|root,COG2038@2|Bacteria,1MVAM@1224|Proteobacteria,42M3Z@68525|delta/epsilon subdivisions,2WJIR@28221|Deltaproteobacteria,43TYS@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB)	cobT	GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008939,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0017144,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042364,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.4.2.21	ko:K00768	ko00860,ko01100,map00860,map01100	M00122	R04148	RC00033,RC00063	ko00000,ko00001,ko00002,ko01000	-	-	-	DBI_PRT
REGS1_k127_1131736_3	909663.KI867150_gene1701	7.637e-50	183.0	COG2087@1|root,COG2087@2|Bacteria,1RH0A@1224|Proteobacteria,42TMF@68525|delta/epsilon subdivisions,2WQNM@28221|Deltaproteobacteria,2MQK1@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate	cobU	-	2.7.1.156,2.7.7.62	ko:K02231	ko00860,ko01100,map00860,map01100	M00122	R05221,R05222,R06558	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	CobU
REGS1_k127_1131736_2	398767.Glov_3559	5.116e-54	199.0	COG1120@1|root,COG1120@2|Bacteria,1QV5A@1224|Proteobacteria,43CPR@68525|delta/epsilon subdivisions,2X7WZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	ABC transporter	-	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
REGS1_k127_1131736_0	398767.Glov_3558	1.671e-92	313.0	COG0609@1|root,COG0609@2|Bacteria,1MV9W@1224|Proteobacteria,42N28@68525|delta/epsilon subdivisions,2WN16@28221|Deltaproteobacteria,43V85@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily	-	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
REGS1_k127_1131736_1	398767.Glov_3557	1.108e-58	213.0	COG0614@1|root,COG0614@2|Bacteria,1MWVF@1224|Proteobacteria,42PQA@68525|delta/epsilon subdivisions,2WKNZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	PFAM periplasmic binding protein	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
REGS1_k127_1145734_3	1499967.BAYZ01000050_gene2864	4.143e-146	474.0	COG0003@1|root,COG0003@2|Bacteria	2|Bacteria	P	Pfam Anion-transporting ATPase	-	-	3.6.3.16	ko:K01551	-	-	-	-	ko00000,ko01000,ko02000	3.A.19.1,3.A.21.1,3.A.4.1	-	-	ArsA_ATPase
REGS1_k127_1145734_11	1131814.JAFO01000001_gene4561	0.0006046	44.0	COG0316@1|root,COG0316@2|Bacteria,1N011@1224|Proteobacteria,2UDNP@28211|Alphaproteobacteria,3F1SR@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	Iron-sulphur cluster biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	Fe-S_biosyn
REGS1_k127_1145734_9	696281.Desru_2111	1.002e-24	107.0	2DMHQ@1|root,32RMG@2|Bacteria,1VB95@1239|Firmicutes,24K45@186801|Clostridia,26204@186807|Peptococcaceae	186801|Clostridia	S	Arsenical resistance operon trans-acting repressor ArsD	arsD	-	-	-	-	-	-	-	-	-	-	-	ArsD
REGS1_k127_1145734_2	207559.Dde_2791	2.929e-167	535.0	COG0798@1|root,COG0798@2|Bacteria,1MUXY@1224|Proteobacteria,42M0Z@68525|delta/epsilon subdivisions,2WK36@28221|Deltaproteobacteria,2M8NG@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	PFAM Bile acid sodium symporter	arsB	-	-	ko:K03325	-	-	-	-	ko00000,ko02000	2.A.59	-	-	SBF
REGS1_k127_1145734_7	760568.Desku_0316	1.894e-44	166.0	COG0394@1|root,COG0394@2|Bacteria,1V3JW@1239|Firmicutes,24HBX@186801|Clostridia,26390@186807|Peptococcaceae	186801|Clostridia	T	Catalyzes the reduction of arsenate As(V) to arsenite As(III)	arsC	-	1.20.4.1	ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
REGS1_k127_1145734_8	909663.KI867150_gene292	9.163e-39	148.0	COG0640@1|root,COG0640@2|Bacteria,1MZT1@1224|Proteobacteria,42VSP@68525|delta/epsilon subdivisions,2WRGT@28221|Deltaproteobacteria,2MSJQ@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
REGS1_k127_1145734_10	289376.THEYE_A0941	9.435e-23	99.0	COG0526@1|root,COG0526@2|Bacteria	2|Bacteria	CO	cell redox homeostasis	-	-	-	-	-	-	-	-	-	-	-	-	DUF4369,Thioredoxin_3
REGS1_k127_1145734_5	269799.Gmet_0515	4.663e-80	273.0	COG0053@1|root,COG0053@2|Bacteria,1ND3V@1224|Proteobacteria,431R3@68525|delta/epsilon subdivisions,2WWYS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Cation efflux family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux
REGS1_k127_1145734_4	289376.THEYE_A0651	6.491e-92	309.0	COG1183@1|root,COG1183@2|Bacteria,3J0KW@40117|Nitrospirae	40117|Nitrospirae	I	CDP-alcohol phosphatidyltransferase	-	-	2.7.8.8	ko:K17103	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	M00093	R01800	RC00002,RC00017,RC02795	ko00000,ko00001,ko00002,ko01000	-	-	-	CDP-OH_P_transf
REGS1_k127_1145734_1	330214.NIDE1002	4.256e-212	669.0	COG0119@1|root,COG0119@2|Bacteria,3J0F7@40117|Nitrospirae	40117|Nitrospirae	E	Belongs to the alpha-IPM synthase homocitrate synthase family	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
REGS1_k127_1145734_0	909663.KI867150_gene1564	0.0	1068.0	COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,42NJD@68525|delta/epsilon subdivisions,2WJFK@28221|Deltaproteobacteria,2MQ92@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	Belongs to the peptidase S16 family	-	-	3.4.21.53	ko:K01338,ko:K04076	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA_32,Lon_C,Mg_chelatase
REGS1_k127_1145734_6	316067.Geob_2104	5.562e-47	176.0	COG1560@1|root,COG1560@2|Bacteria,1MVNI@1224|Proteobacteria,42N6U@68525|delta/epsilon subdivisions,2WQ3X@28221|Deltaproteobacteria,43UMV@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	PFAM lipid A biosynthesis acyltransferase	htrB	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
REGS1_k127_1159256_2	443143.GM18_1375	8.413e-06	53.0	2E6Z6@1|root,331IC@2|Bacteria,1NY0D@1224|Proteobacteria,430VK@68525|delta/epsilon subdivisions,2WVKD@28221|Deltaproteobacteria,43VJN@69541|Desulfuromonadales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_1159256_1	909663.KI867149_gene3436	4.712e-32	136.0	COG3209@1|root,COG3209@2|Bacteria,1PGQF@1224|Proteobacteria,43F38@68525|delta/epsilon subdivisions,2X37N@28221|Deltaproteobacteria,2MSB0@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	COG3209 Rhs family protein	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_1159256_0	1232410.KI421424_gene1673	0.0	1067.0	COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,42MGP@68525|delta/epsilon subdivisions,2WIZ2@28221|Deltaproteobacteria,43RZ4@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	Bacterial DNA polymerase III alpha subunit	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
REGS1_k127_1177614_5	399795.CtesDRAFT_PD1596	3.327e-34	140.0	2DBPG@1|root,2ZA96@2|Bacteria,1QVNF@1224|Proteobacteria,2VP5D@28216|Betaproteobacteria,4ACJ0@80864|Comamonadaceae	28216|Betaproteobacteria	M	Domain of unknown function (DUF4382)	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,DUF4382
REGS1_k127_1177614_0	335543.Sfum_2640	1.427e-142	464.0	29QS6@1|root,30BS1@2|Bacteria,1REGY@1224|Proteobacteria,42RJ2@68525|delta/epsilon subdivisions,2WNQQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_1177614_6	314345.SPV1_04403	7.806e-20	98.0	COG4254@1|root,COG4254@2|Bacteria,1NATC@1224|Proteobacteria	1224|Proteobacteria	M	FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	FecR
REGS1_k127_1177614_7	944479.JQLX01000013_gene1439	1.812e-07	63.0	COG0457@1|root,COG0457@2|Bacteria,1NI26@1224|Proteobacteria,42WVU@68525|delta/epsilon subdivisions,2WT35@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	BBP2_2,TPR_16,TPR_19
REGS1_k127_1177614_4	909663.KI867150_gene1034	1.86e-60	215.0	COG3762@1|root,COG3762@2|Bacteria,1R61N@1224|Proteobacteria,42UTC@68525|delta/epsilon subdivisions,2WR18@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Pfam:TPM	-	-	-	ko:K08988	-	-	-	-	ko00000	-	-	-	TPM_phosphatase
REGS1_k127_1177614_3	909663.KI867150_gene1033	4.368e-75	265.0	COG1512@1|root,COG1512@2|Bacteria,1PB41@1224|Proteobacteria,42R0Q@68525|delta/epsilon subdivisions,2WN87@28221|Deltaproteobacteria,2MS9N@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	TPM domain	-	-	-	ko:K06872	-	-	-	-	ko00000	-	-	-	TPM_phosphatase
REGS1_k127_1177614_1	443144.GM21_1794	1.267e-90	301.0	COG1704@1|root,COG1704@2|Bacteria,1MVH0@1224|Proteobacteria,42R4C@68525|delta/epsilon subdivisions,2WKG9@28221|Deltaproteobacteria,43S01@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	PFAM LemA family protein	-	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
REGS1_k127_1177614_2	247490.KSU1_D0014	6.617e-82	283.0	COG0642@1|root,COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG2205@2|Bacteria,COG4191@2|Bacteria,2IZWU@203682|Planctomycetes	203682|Planctomycetes	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg
REGS1_k127_1221156_0	289376.THEYE_A1347	0.0	1817.0	COG0085@1|root,COG0085@2|Bacteria,3J0CW@40117|Nitrospirae	40117|Nitrospirae	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
REGS1_k127_1221156_1	289376.THEYE_A1346	8.548e-297	917.0	COG0086@1|root,COG0086@2|Bacteria,3J0BT@40117|Nitrospirae	40117|Nitrospirae	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
REGS1_k127_1229299_0	289376.THEYE_A1795	8.145e-111	366.0	COG2870@1|root,COG2870@2|Bacteria,3J0GT@40117|Nitrospirae	40117|Nitrospirae	M	Phosphomethylpyrimidine kinase	-	-	2.7.1.167,2.7.7.70	ko:K03272	ko00540,ko01100,map00540,map01100	M00064	R05644,R05646	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	PfkB
REGS1_k127_1229299_1	1125863.JAFN01000001_gene370	1.229e-83	285.0	COG0301@1|root,COG0301@2|Bacteria,1N1R1@1224|Proteobacteria,42MQ9@68525|delta/epsilon subdivisions,2WJPN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Thiamine biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF814,ThiI
REGS1_k127_1256831_1	1265505.ATUG01000001_gene3620	9.837e-52	187.0	COG0225@1|root,COG0225@2|Bacteria,1N2DQ@1224|Proteobacteria,42UC3@68525|delta/epsilon subdivisions,2WQBZ@28221|Deltaproteobacteria,2MNC1@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Peptide methionine sulfoxide reductase	msrA	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
REGS1_k127_1256831_4	1125863.JAFN01000001_gene1465	7.831e-11	69.0	2A816@1|root,30X1I@2|Bacteria,1PIU3@1224|Proteobacteria,432YM@68525|delta/epsilon subdivisions,2WXEE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_1256831_2	1304885.AUEY01000005_gene887	4.833e-46	168.0	COG3123@1|root,COG3123@2|Bacteria,1MZ8N@1224|Proteobacteria,42TQH@68525|delta/epsilon subdivisions,2WQ2M@28221|Deltaproteobacteria,2MNRY@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF1255)	ppnP	-	2.4.2.1,2.4.2.2	ko:K09913	ko00230,ko00240,map00230,map00240	-	R01561,R01570,R01863,R01876,R02147,R02296,R02297	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	DUF1255
REGS1_k127_1256831_3	706587.Desti_3965	1.441e-21	101.0	COG0666@1|root,COG0666@2|Bacteria,1NH1G@1224|Proteobacteria	1224|Proteobacteria	S	FOG Ankyrin repeat	-	-	-	ko:K06867,ko:K21440	-	-	-	-	ko00000,ko04131	-	-	-	Ank_2,Ank_4,Ank_5
REGS1_k127_1256831_0	1121448.DGI_2887	5.081e-208	657.0	COG1760@1|root,COG1760@2|Bacteria,1MUZN@1224|Proteobacteria,42N88@68525|delta/epsilon subdivisions,2WISX@28221|Deltaproteobacteria,2M8PI@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	PFAM serine dehydratase alpha chain	-	-	4.3.1.17	ko:K01752	ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230	-	R00220,R00590	RC00331,RC02600	ko00000,ko00001,ko01000	-	-	-	SDH_alpha,SDH_beta
REGS1_k127_1265333_1	1242864.D187_003259	0.0006609	49.0	2BS7F@1|root,32M8R@2|Bacteria,1Q33Y@1224|Proteobacteria,433XP@68525|delta/epsilon subdivisions,2X2HG@28221|Deltaproteobacteria,2YXTX@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_1265333_0	289376.THEYE_A1004	1.234e-184	585.0	COG0148@1|root,COG0148@2|Bacteria,3J0DB@40117|Nitrospirae	40117|Nitrospirae	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
REGS1_k127_1277170_1	1121468.AUBR01000008_gene2058	4.569e-08	57.0	COG1228@1|root,COG1228@2|Bacteria,1TQQ0@1239|Firmicutes,24EHA@186801|Clostridia,42GIK@68295|Thermoanaerobacterales	186801|Clostridia	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
REGS1_k127_1277170_0	1267535.KB906767_gene2350	4.381e-263	822.0	COG1217@1|root,COG1217@2|Bacteria,3Y33Q@57723|Acidobacteria,2JIIC@204432|Acidobacteriia	204432|Acidobacteriia	T	GTP-binding protein TypA	-	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
REGS1_k127_129947_2	477641.MODMU_3779	0.0006075	50.0	COG3850@1|root,COG5001@1|root,COG3850@2|Bacteria,COG5001@2|Bacteria,2GIZF@201174|Actinobacteria	201174|Actinobacteria	T	signal transduction protein containing a membrane domain an EAL and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS,PAS_4,PAS_9,Peripla_BP_3
REGS1_k127_129947_1	671143.DAMO_2558	3.145e-130	431.0	COG0297@1|root,COG0297@2|Bacteria,2NP1F@2323|unclassified Bacteria	2|Bacteria	G	Synthesizes alpha-1,4-glucan chains using ADP-glucose	glgA	GO:0003674,GO:0003824,GO:0016740,GO:0016757	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
REGS1_k127_129947_0	289376.THEYE_A1493	2.393e-150	479.0	COG1085@1|root,COG1085@2|Bacteria,3J0ER@40117|Nitrospirae	40117|Nitrospirae	H	Galactose-1-phosphate uridyl transferase, N-terminal domain	galT	-	2.7.7.12	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	M00362,M00554,M00632	R00955	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	GalP_UDP_tr_C,GalP_UDP_transf
REGS1_k127_1304584_1	909663.KI867149_gene3402	2.105e-98	325.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,42MV1@68525|delta/epsilon subdivisions,2WM7T@28221|Deltaproteobacteria,2MQFC@213462|Syntrophobacterales	28221|Deltaproteobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990,ko:K09695	ko02010,map02010	M00252,M00254	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.102	-	-	ABC_tran,DUF4162
REGS1_k127_1304584_0	909663.KI867149_gene3401	2.841e-101	336.0	COG0842@1|root,COG0842@2|Bacteria,1N55T@1224|Proteobacteria,42N8F@68525|delta/epsilon subdivisions,2WK3B@28221|Deltaproteobacteria,2MQHF@213462|Syntrophobacterales	28221|Deltaproteobacteria	V	ABC-2 type transporter	-	-	-	ko:K09694	ko02010,map02010	M00252	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.102	-	-	ABC2_membrane
REGS1_k127_1311387_6	269799.Gmet_0694	1.039e-33	130.0	COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,42SJJ@68525|delta/epsilon subdivisions,2WP4E@28221|Deltaproteobacteria,43V1V@69541|Desulfuromonadales	28221|Deltaproteobacteria	K	Nitrogen regulatory protein P-II	glnK	-	-	ko:K04751	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
REGS1_k127_1311387_0	667014.Thein_2196	4.493e-235	734.0	COG0174@1|root,COG0174@2|Bacteria,2GH5N@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	E	Glutamine synthetase, catalytic domain	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
REGS1_k127_1311387_5	1401067.HMPREF0872_01125	1.739e-64	243.0	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,1TP3F@1239|Firmicutes,4H2BH@909932|Negativicutes	909932|Negativicutes	KLT	serine threonine protein kinase	prkC	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
REGS1_k127_1311387_4	933262.AXAM01000025_gene3430	4.163e-74	256.0	COG0631@1|root,COG0631@2|Bacteria,1R7UF@1224|Proteobacteria,42QUA@68525|delta/epsilon subdivisions,2WMWM@28221|Deltaproteobacteria,2MJKU@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Serine/threonine phosphatases, family 2C, catalytic domain	-	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C_2
REGS1_k127_1311387_1	1499967.BAYZ01000190_gene3817	4.167e-216	680.0	COG1249@1|root,COG1249@2|Bacteria	2|Bacteria	C	cell redox homeostasis	merA	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim
REGS1_k127_1311387_3	289376.THEYE_A0053	1.485e-90	305.0	COG3359@1|root,COG3359@2|Bacteria,3J137@40117|Nitrospirae	40117|Nitrospirae	L	RNase_H superfamily	-	-	-	ko:K07502	-	-	-	-	ko00000	-	-	-	RNase_H_2
REGS1_k127_1311387_2	1123376.AUIU01000011_gene830	6.018e-94	316.0	COG4974@1|root,COG4974@2|Bacteria,3J0KV@40117|Nitrospirae	40117|Nitrospirae	D	Phage integrase, N-terminal SAM-like domain	xerD	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
REGS1_k127_1316713_0	289376.THEYE_A1106	3.583e-165	535.0	COG1197@1|root,COG1197@2|Bacteria,3J0BA@40117|Nitrospirae	40117|Nitrospirae	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
REGS1_k127_1337084_1	1123376.AUIU01000013_gene1726	9.399e-138	447.0	COG0593@1|root,COG0593@2|Bacteria,3J0FQ@40117|Nitrospirae	40117|Nitrospirae	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
REGS1_k127_1337084_2	1123376.AUIU01000013_gene1727	3.34e-106	355.0	COG0592@1|root,COG0592@2|Bacteria,3J0RU@40117|Nitrospirae	40117|Nitrospirae	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	dnaN	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
REGS1_k127_1337084_0	289376.THEYE_A0017	2.009e-298	935.0	COG0187@1|root,COG0187@2|Bacteria,3J0BB@40117|Nitrospirae	40117|Nitrospirae	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
REGS1_k127_1337133_2	931626.Awo_c07580	1.814e-53	190.0	COG2070@1|root,COG2070@2|Bacteria,1UJNK@1239|Firmicutes,25F6P@186801|Clostridia	186801|Clostridia	S	PFAM ferredoxin-dependent glutamate synthase	-	-	-	-	-	-	-	-	-	-	-	-	Glu_synthase
REGS1_k127_1337133_0	1123373.ATXI01000003_gene1294	1.938e-274	851.0	COG1304@1|root,COG1304@2|Bacteria,2GHFE@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	C	Conserved region in glutamate synthase	-	-	-	-	-	-	-	-	-	-	-	-	Glu_synthase
REGS1_k127_1337133_1	909663.KI867150_gene1083	9.019e-115	379.0	COG1693@1|root,COG1693@2|Bacteria,1RAC2@1224|Proteobacteria,42QW9@68525|delta/epsilon subdivisions,2WMZV@28221|Deltaproteobacteria,2MQWZ@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Ribonuclease R winged-helix domain	-	-	-	ko:K09720	-	-	-	-	ko00000,ko03000	-	-	-	DUF128,HTH_12
REGS1_k127_1337133_3	648996.Theam_0628	3.904e-51	183.0	COG0347@1|root,COG0347@2|Bacteria,2G43N@200783|Aquificae	200783|Aquificae	K	Belongs to the P(II) protein family	-	-	-	ko:K04751	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
REGS1_k127_1369545_0	671143.DAMO_2479	2.473e-76	280.0	COG1450@1|root,COG1450@2|Bacteria,2NQ01@2323|unclassified Bacteria	2|Bacteria	NU	Bacterial type II and III secretion system protein	gspD	-	-	ko:K02453,ko:K03219	ko03070,ko05111,map03070,map05111	M00331,M00332,M00542	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15,3.A.6.1,3.A.6.3	-	-	Secretin,Secretin_N
REGS1_k127_1369545_1	439235.Dalk_2218	2.048e-61	219.0	COG1216@1|root,COG1216@2|Bacteria,1QW1K@1224|Proteobacteria,43BRI@68525|delta/epsilon subdivisions,2WN0V@28221|Deltaproteobacteria,2MM2M@213118|Desulfobacterales	28221|Deltaproteobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
REGS1_k127_1369545_3	1283299.AUKG01000001_gene2259	2.906e-10	65.0	COG2456@1|root,COG2456@2|Bacteria,2HR2A@201174|Actinobacteria,4CSX5@84995|Rubrobacteria	84995|Rubrobacteria	S	Uncharacterized conserved protein (DUF2304)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2304
REGS1_k127_1369545_2	439235.Dalk_2170	3.163e-50	203.0	COG0457@1|root,COG0457@2|Bacteria,1NFQW@1224|Proteobacteria,42MT2@68525|delta/epsilon subdivisions,2WKWA@28221|Deltaproteobacteria,2MJFK@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_2,TPR_4,TPR_8
REGS1_k127_1369545_4	608538.HTH_1652	9.475e-06	49.0	COG0438@1|root,COG0438@2|Bacteria,2G4RK@200783|Aquificae	200783|Aquificae	H	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4
REGS1_k127_1370580_0	671143.DAMO_2489	4.176e-106	357.0	COG2804@1|root,COG2804@2|Bacteria,2NNNI@2323|unclassified Bacteria	2|Bacteria	NU	Type II secretion system (T2SS), protein E, N-terminal domain	xpsE	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K02454,ko:K02652	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	T2SSE,T2SSE_N
REGS1_k127_1370580_1	1123376.AUIU01000011_gene1045	1.829e-96	328.0	COG0787@1|root,COG0787@2|Bacteria,3J0JH@40117|Nitrospirae	40117|Nitrospirae	E	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
REGS1_k127_1370580_2	289376.THEYE_A0340	6.876e-20	90.0	COG1826@1|root,COG1826@2|Bacteria,3J1A4@40117|Nitrospirae	40117|Nitrospirae	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	-	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
REGS1_k127_1407803_1	555779.Dthio_PD3238	1.175e-63	223.0	COG0369@1|root,COG1151@2|Bacteria,1NYH2@1224|Proteobacteria,42NE1@68525|delta/epsilon subdivisions,2WIVX@28221|Deltaproteobacteria,2M9QY@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	TIGRFAM Carbon-monoxide dehydrogenase, catalytic subunit	-	-	1.2.7.4	ko:K00198	ko00633,ko00680,ko00720,ko01120,ko01200,map00633,map00680,map00720,map01120,map01200	M00377	R07157,R08034	RC00250,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Prismane
REGS1_k127_1407803_0	555779.Dthio_PD3239	3.333e-262	826.0	COG1614@1|root,COG1614@2|Bacteria,1MVI5@1224|Proteobacteria,42N9A@68525|delta/epsilon subdivisions,2WK4H@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM CO dehydrogenase acetyl-CoA synthase complex beta subunit	-	-	2.3.1.169	ko:K14138	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00377	R08433,R10243	RC00004,RC00113,RC01144,RC02963,RC02964,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhC
REGS1_k127_1407803_2	289376.THEYE_A1471	1.778e-47	172.0	COG1456@1|root,COG1456@2|Bacteria	2|Bacteria	C	acetyl-CoA catabolic process	acsC	-	2.1.1.245	ko:K00197	ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200	M00357,M00377,M00422	R09096,R10219,R10243	RC00004,RC00113,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhD,FeS
REGS1_k127_1416544_0	56780.SYN_01481	4.869e-46	187.0	COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,42N5S@68525|delta/epsilon subdivisions,2WIUS@28221|Deltaproteobacteria,2MQZ2@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	Adenylyl cyclase class-3 4 guanylyl cyclase	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc
REGS1_k127_1416544_2	1123376.AUIU01000015_gene364	4.755e-41	156.0	COG1611@1|root,COG1611@2|Bacteria,3J0TX@40117|Nitrospirae	40117|Nitrospirae	S	Belongs to the LOG family	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	-
REGS1_k127_1416544_3	1313304.CALK_2268	0.0007647	44.0	COG0694@1|root,COG0694@2|Bacteria	2|Bacteria	O	iron-sulfur cluster assembly	nifU	-	-	-	-	-	-	-	-	-	-	-	NifU
REGS1_k127_1416544_1	192952.MM_0667	3.904e-42	157.0	COG0778@1|root,arCOG00288@2157|Archaea,2Y7D7@28890|Euryarchaeota,2NAYZ@224756|Methanomicrobia	224756|Methanomicrobia	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
REGS1_k127_1457372_1	909663.KI867150_gene214	2.054e-72	265.0	COG0457@1|root,COG1807@1|root,COG0457@2|Bacteria,COG1807@2|Bacteria,1NNJ6@1224|Proteobacteria,42PBD@68525|delta/epsilon subdivisions,2WKWJ@28221|Deltaproteobacteria,2MRCI@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	PFAM Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2,TPR_1,TPR_11,TPR_16,TPR_17,TPR_2,TPR_8
REGS1_k127_1457372_0	760154.Sulba_2458	5.227e-138	446.0	COG1088@1|root,COG1088@2|Bacteria,1MU5E@1224|Proteobacteria,42MFN@68525|delta/epsilon subdivisions,2YNDN@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	M	Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily	-	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
REGS1_k127_1457372_3	402626.Rpic_1490	7.613e-36	145.0	COG0500@1|root,COG2226@2|Bacteria,1RFBE@1224|Proteobacteria,2VJY1@28216|Betaproteobacteria,1K66S@119060|Burkholderiaceae	28216|Betaproteobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25
REGS1_k127_1457372_2	204773.HEAR1125	7.696e-41	159.0	COG0500@1|root,COG2226@2|Bacteria,1N867@1224|Proteobacteria	1224|Proteobacteria	Q	Nodulation protein S (NodS)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
REGS1_k127_1470534_0	1123376.AUIU01000014_gene724	6.609e-133	435.0	COG4591@1|root,COG4591@2|Bacteria,3J0EF@40117|Nitrospirae	40117|Nitrospirae	M	MacB-like periplasmic core domain	-	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
REGS1_k127_1470534_1	56780.SYN_00922	5.723e-72	249.0	COG1136@1|root,COG1136@2|Bacteria,1MVSQ@1224|Proteobacteria,42QNS@68525|delta/epsilon subdivisions,2WMSN@28221|Deltaproteobacteria,2MQF7@213462|Syntrophobacterales	28221|Deltaproteobacteria	V	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner	lolD	-	-	ko:K09810	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.125	-	-	ABC_tran
REGS1_k127_1470534_2	1267535.KB906767_gene646	1.123e-32	128.0	COG5552@1|root,COG5552@2|Bacteria	2|Bacteria	S	Uncharacterized conserved protein (DUF2277)	MA20_01405	-	-	-	-	-	-	-	-	-	-	-	DUF2277
REGS1_k127_1470534_3	755178.Cyan10605_1639	8.58e-26	108.0	2E46S@1|root,32Z2Q@2|Bacteria,1GA29@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_147775_6	448385.sce2756	9.86e-13	79.0	COG1413@1|root,COG1413@2|Bacteria,1RK8P@1224|Proteobacteria,42VXW@68525|delta/epsilon subdivisions,2WRH4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PBS lyase HEAT-like repeat	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
REGS1_k127_147775_0	269799.Gmet_2305	1.364e-109	362.0	COG1352@1|root,COG1352@2|Bacteria,1MU6W@1224|Proteobacteria,42QPJ@68525|delta/epsilon subdivisions,2WMNM@28221|Deltaproteobacteria,43UG4@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP	cheR40H-1	-	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheR,CheR_N
REGS1_k127_147775_1	243231.GSU2214	1.274e-92	316.0	COG2201@1|root,COG2201@2|Bacteria,1R5IM@1224|Proteobacteria,42Q4X@68525|delta/epsilon subdivisions,2WMDB@28221|Deltaproteobacteria,43T38@69541|Desulfuromonadales	28221|Deltaproteobacteria	NT	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	cheB40H-1	-	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,Response_reg
REGS1_k127_147775_2	1232410.KI421413_gene806	2.67e-90	304.0	COG2203@1|root,COG2203@2|Bacteria,1RJ35@1224|Proteobacteria,42T0K@68525|delta/epsilon subdivisions,2WPIM@28221|Deltaproteobacteria,43T60@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GAF_3
REGS1_k127_147775_5	1121918.ARWE01000001_gene1277	9.215e-45	165.0	COG2199@1|root,COG3706@2|Bacteria,1N0N3@1224|Proteobacteria,43CGB@68525|delta/epsilon subdivisions,2X60G@28221|Deltaproteobacteria,43W37@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	cheY-homologous receiver domain	-	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
REGS1_k127_147775_3	1232437.KL662047_gene5175	1.429e-55	197.0	COG1917@1|root,COG1917@2|Bacteria,1N0G1@1224|Proteobacteria,42U3P@68525|delta/epsilon subdivisions,2WPN5@28221|Deltaproteobacteria,2MNEN@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
REGS1_k127_147775_4	237368.SCABRO_03062	1.648e-47	177.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1,Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31
REGS1_k127_1494402_0	289376.THEYE_A0147	1.356e-203	640.0	COG0001@1|root,COG0001@2|Bacteria,3J0B3@40117|Nitrospirae	40117|Nitrospirae	H	Aminotransferase class-III	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
REGS1_k127_1494402_1	404589.Anae109_0112	1.199e-33	142.0	COG0484@1|root,COG0484@2|Bacteria	2|Bacteria	O	heat shock protein binding	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_1509956_2	1046714.AMRX01000001_gene1408	1.564e-36	145.0	COG4262@1|root,COG4262@2|Bacteria,1RFZS@1224|Proteobacteria,1S1NP@1236|Gammaproteobacteria,468RU@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_1509956_1	1278073.MYSTI_06053	1.943e-44	173.0	COG0421@1|root,COG0421@2|Bacteria,1N1PJ@1224|Proteobacteria,43C7V@68525|delta/epsilon subdivisions,2X7I7@28221|Deltaproteobacteria,2Z1WH@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	-	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synth
REGS1_k127_1509956_0	388413.ALPR1_13335	5.21e-182	589.0	COG1233@1|root,COG1233@2|Bacteria	2|Bacteria	Q	all-trans-retinol 13,14-reductase activity	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase,FAD_oxidored
REGS1_k127_1516787_3	338966.Ppro_0378	7.227e-40	152.0	COG2204@1|root,COG2204@2|Bacteria,1PAPS@1224|Proteobacteria,42NMK@68525|delta/epsilon subdivisions,2WK6K@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Sigma-54 factor interaction domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
REGS1_k127_1516787_1	338966.Ppro_0377	1.338e-122	421.0	COG2202@1|root,COG3829@1|root,COG4191@1|root,COG2202@2|Bacteria,COG3829@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42PZ5@68525|delta/epsilon subdivisions,2WM1A@28221|Deltaproteobacteria,43U1A@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	PFAM ATP-binding region, ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_9
REGS1_k127_1516787_2	316067.Geob_1643	9.172e-70	242.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,43BJY@68525|delta/epsilon subdivisions,2WIWD@28221|Deltaproteobacteria,43TK1@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Molybdopterin oxidoreductase Fe4S4 domain	fdnG-2	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal
REGS1_k127_1516787_0	1123376.AUIU01000014_gene673	0.0	1245.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,3J0UR@40117|Nitrospirae	40117|Nitrospirae	C	Molydopterin dinucleotide binding domain	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
REGS1_k127_1516787_4	255470.cbdbA131	2.762e-10	61.0	COG0437@1|root,COG0437@2|Bacteria,2G6VF@200795|Chloroflexi,34D8G@301297|Dehalococcoidia	301297|Dehalococcoidia	C	PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	ko:K00124	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001	-	-	-	Fer4_11,Fer4_4
REGS1_k127_1540971_0	322710.Avin_45490	6.475e-82	278.0	COG1385@1|root,COG1385@2|Bacteria,1MZBG@1224|Proteobacteria,1S0HM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	-	-	-	-	-	-	-	-	-	-	-	-	Methyltrans_RNA
REGS1_k127_1540971_1	1232410.KI421415_gene2936	2.664e-79	268.0	COG0778@1|root,COG0778@2|Bacteria,1MZN8@1224|Proteobacteria,42SJF@68525|delta/epsilon subdivisions,2WP4X@28221|Deltaproteobacteria,43U8B@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
REGS1_k127_1544137_2	1123376.AUIU01000011_gene1069	1.818e-05	50.0	COG0470@1|root,COG0470@2|Bacteria,3J16Q@40117|Nitrospirae	40117|Nitrospirae	L	DNA polymerase III, delta subunit	-	-	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2
REGS1_k127_1544137_1	246194.CHY_0052	2.528e-71	250.0	COG1774@1|root,COG1774@2|Bacteria,1TP1V@1239|Firmicutes,247Q6@186801|Clostridia,42ETV@68295|Thermoanaerobacterales	186801|Clostridia	S	PSP1 domain protein	yaaT	-	-	-	-	-	-	-	-	-	-	-	PSP1
REGS1_k127_1544137_0	289376.THEYE_A0382	5.139e-139	447.0	COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,3J0AI@40117|Nitrospirae	40117|Nitrospirae	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
REGS1_k127_156055_4	335543.Sfum_2395	2.037e-11	66.0	COG1914@1|root,COG1914@2|Bacteria,1N0XH@1224|Proteobacteria,43B4Q@68525|delta/epsilon subdivisions,2X6IC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	PFAM natural resistance-associated macrophage protein	-	-	-	-	-	-	-	-	-	-	-	-	Nramp
REGS1_k127_156055_1	316067.Geob_0760	9.157e-74	252.0	28HPC@1|root,2Z7XD@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4337)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4337
REGS1_k127_156055_0	289376.THEYE_A1139	4.244e-108	362.0	COG1092@1|root,COG1092@2|Bacteria,3J0IV@40117|Nitrospirae	40117|Nitrospirae	J	S-adenosylmethionine-dependent methyltransferase	-	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
REGS1_k127_156055_3	289376.THEYE_A0153	4.831e-40	158.0	COG1525@1|root,COG1525@2|Bacteria	2|Bacteria	L	nuclease	nucH	GO:0003674,GO:0003824,GO:0004518,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:1901360,GO:1901361,GO:1901575	2.1.1.113,3.1.31.1	ko:K00590,ko:K01174	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	Excalibur,SNase
REGS1_k127_156055_2	661478.OP10G_0435	1.299e-70	253.0	COG3437@1|root,COG3437@2|Bacteria	2|Bacteria	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	CHASE2,GAF,GAF_2,GAF_3,HD,HD_5,PAS,PAS_3,PAS_4,PAS_9,Response_reg
REGS1_k127_1569090_1	1395513.P343_03450	5.527e-52	196.0	COG0669@1|root,COG0669@2|Bacteria,1V3MR@1239|Firmicutes,4HH47@91061|Bacilli,26NRN@186821|Sporolactobacillaceae	91061|Bacilli	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	-	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
REGS1_k127_1569090_2	292459.STH1438	2.227e-33	136.0	COG0742@1|root,COG0742@2|Bacteria,1V3JF@1239|Firmicutes,24JHR@186801|Clostridia	186801|Clostridia	L	RNA methyltransferase, RsmD family	rsmD	-	2.1.1.171	ko:K08316	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Cons_hypoth95
REGS1_k127_1569090_0	289376.THEYE_A0758	9.987e-279	871.0	COG0466@1|root,COG0466@2|Bacteria,3J0DQ@40117|Nitrospirae	40117|Nitrospirae	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,Lon_C,Response_reg
REGS1_k127_157275_3	398767.Glov_1657	3.399e-56	202.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,43UCF@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	response regulator	pilR	-	-	ko:K02667	ko02020,map02020	M00501	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	HTH_8,Response_reg,Sigma54_activat
REGS1_k127_157275_4	316067.Geob_3655	1.461e-48	186.0	COG1413@1|root,COG1413@2|Bacteria,1QX4H@1224|Proteobacteria,42Z02@68525|delta/epsilon subdivisions,2WUJ9@28221|Deltaproteobacteria,43VYE@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Type II secretion system (T2SS), protein E, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,T2SSE_N
REGS1_k127_157275_0	289376.THEYE_A0678	4.129e-203	646.0	COG0029@1|root,COG0029@2|Bacteria,3J0DI@40117|Nitrospirae	40117|Nitrospirae	H	FAD binding domain	nadB	-	1.4.3.16	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481	RC00006,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
REGS1_k127_157275_1	338963.Pcar_2983	2.83e-128	424.0	COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,42N30@68525|delta/epsilon subdivisions,2WJSW@28221|Deltaproteobacteria,43TCB@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	Belongs to the pyruvate kinase family	pyk	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	iAF987.Gmet_0122	Fer4_9,PK,PK_C
REGS1_k127_157275_2	1125863.JAFN01000001_gene365	2.627e-76	259.0	COG1611@1|root,COG1611@2|Bacteria,1MU6N@1224|Proteobacteria,42P56@68525|delta/epsilon subdivisions,2WK5J@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Belongs to the LOG family	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
REGS1_k127_1588797_2	324925.Ppha_0514	4.746e-130	425.0	COG0514@1|root,COG0514@2|Bacteria,1FDF2@1090|Chlorobi	1090|Chlorobi	L	DEAD DEAH box helicase domain protein	-	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,HRDC,Helicase_C,RQC,RecQ_Zn_bind
REGS1_k127_1588797_10	335543.Sfum_1729	1.516e-66	231.0	COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,42SQU@68525|delta/epsilon subdivisions,2WPRP@28221|Deltaproteobacteria,2MRV2@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	[2Fe-2S] binding domain	-	-	1.3.99.16	ko:K07302	-	-	-	-	ko00000,ko01000	-	-	-	Fer2,Fer2_2
REGS1_k127_1588797_0	335543.Sfum_1730	2.376e-249	790.0	COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,42NU9@68525|delta/epsilon subdivisions,2WKXG@28221|Deltaproteobacteria,2MRDM@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL CutL-like protein	-	-	1.3.99.16	ko:K07303	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2,Fer2_2
REGS1_k127_1588797_5	221288.JH992901_gene3454	1.233e-102	340.0	COG0412@1|root,COG0412@2|Bacteria,1G4HV@1117|Cyanobacteria	1117|Cyanobacteria	Q	dienelactone hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	DLH
REGS1_k127_1588797_8	243231.GSU0202	1.353e-70	248.0	COG1975@1|root,COG1975@2|Bacteria,1MXKU@1224|Proteobacteria,42QUY@68525|delta/epsilon subdivisions,2WMVP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	NTP_transf_3,XdhC_C,XdhC_CoxI
REGS1_k127_1588797_14	243231.GSU0203	6.959e-48	179.0	COG2068@1|root,COG2068@2|Bacteria,1RAAE@1224|Proteobacteria	1224|Proteobacteria	S	PFAM Metal-dependent phosphohydrolase, HD	-	-	2.7.7.76	ko:K07141	ko00790,map00790	-	R11582	-	ko00000,ko00001,ko01000	-	-	-	HD,NTP_transf_3
REGS1_k127_1588797_12	105559.Nwat_0860	6.844e-60	215.0	COG4446@1|root,COG4446@2|Bacteria,1N31A@1224|Proteobacteria,1RRKY@1236|Gammaproteobacteria,1X0TK@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function (DUF1499)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1499
REGS1_k127_1588797_3	289376.THEYE_A1970	3.909e-127	415.0	COG3264@1|root,COG3264@2|Bacteria,3J0R7@40117|Nitrospirae	40117|Nitrospirae	M	Mechanosensitive ion channel	-	-	-	ko:K03442	-	-	-	-	ko00000,ko02000	1.A.23.2	-	-	MS_channel
REGS1_k127_1588797_13	1232410.KI421416_gene2615	5.392e-55	198.0	COG2206@1|root,COG2206@2|Bacteria,1REAA@1224|Proteobacteria,42S1X@68525|delta/epsilon subdivisions,2WNGR@28221|Deltaproteobacteria,43SIV@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Metal-dependent phosphohydrolase	-	-	-	ko:K06950	-	-	-	-	ko00000	-	-	-	HD
REGS1_k127_1588797_9	340099.Teth39_0407	8.44e-68	240.0	COG0101@1|root,COG0101@2|Bacteria,1TQUY@1239|Firmicutes,248W2@186801|Clostridia,42FMH@68295|Thermoanaerobacterales	186801|Clostridia	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	-	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
REGS1_k127_1588797_6	1459636.NTE_03099	1.711e-84	287.0	COG4912@1|root,arCOG05122@2157|Archaea	2157|Archaea	L	PFAM DNA alkylation repair enzyme	-	-	-	-	-	-	-	-	-	-	-	-	DNA_alkylation
REGS1_k127_1588797_1	316067.Geob_2270	1.394e-166	530.0	COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,42M27@68525|delta/epsilon subdivisions,2WJ2S@28221|Deltaproteobacteria,43S6W@69541|Desulfuromonadales	28221|Deltaproteobacteria	NT	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	cheB34H	-	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,Response_reg
REGS1_k127_1588797_15	243231.GSU1144	1.111e-33	139.0	COG1871@1|root,COG1871@2|Bacteria,1RI55@1224|Proteobacteria,42W4V@68525|delta/epsilon subdivisions,2WRZ4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	NT	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis	cheD	-	3.5.1.44	ko:K03411	ko02030,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheD
REGS1_k127_1588797_4	269799.Gmet_2420	1.499e-116	383.0	COG1352@1|root,COG1352@2|Bacteria,1MU6W@1224|Proteobacteria,42MR2@68525|delta/epsilon subdivisions,2WKKH@28221|Deltaproteobacteria,43SBQ@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP	cheR34H	-	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheR,CheR_N,Response_reg
REGS1_k127_1588797_7	909663.KI867150_gene362	8.784e-75	254.0	COG0835@1|root,COG0835@2|Bacteria,1RAH1@1224|Proteobacteria,42SH0@68525|delta/epsilon subdivisions,2WPFU@28221|Deltaproteobacteria,2MS7I@213462|Syntrophobacterales	28221|Deltaproteobacteria	NT	Two component signalling adaptor domain	-	-	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
REGS1_k127_1588797_11	573370.DMR_27400	3.76e-63	222.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,42KZR@68525|delta/epsilon subdivisions,2WJ2T@28221|Deltaproteobacteria,2M7RA@213115|Desulfovibrionales	28221|Deltaproteobacteria	NT	PFAM chemotaxis	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,HAMP,HBM,MCPsignal
REGS1_k127_159536_0	398767.Glov_1116	1.772e-60	214.0	COG2984@1|root,COG2984@2|Bacteria	2|Bacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
REGS1_k127_159536_1	706587.Desti_3270	1.604e-48	194.0	COG2202@1|root,COG2203@1|root,COG2204@1|root,COG4191@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2204@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIU5@28221|Deltaproteobacteria,2MQZQ@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
REGS1_k127_1636161_0	269799.Gmet_0566	2.626e-141	455.0	COG0535@1|root,COG0535@2|Bacteria,1MUQP@1224|Proteobacteria,42N9E@68525|delta/epsilon subdivisions	1224|Proteobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	-	ko:K22226	-	-	-	-	ko00000	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
REGS1_k127_1636161_3	316067.Geob_3351	1.242e-61	223.0	COG0535@1|root,COG0535@2|Bacteria	2|Bacteria	I	radical SAM domain protein	pqqC	-	1.3.3.11	ko:K06137,ko:K06138	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,PqqD,Radical_SAM,SPASM,TENA_THI-4
REGS1_k127_1636161_2	316067.Geob_1467	9.892e-88	311.0	COG0457@1|root,COG0457@2|Bacteria,1NFQW@1224|Proteobacteria,42MT2@68525|delta/epsilon subdivisions,2WKWA@28221|Deltaproteobacteria,43TXB@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	PFAM Tetratricopeptide TPR_1 repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_2,TPR_4,TPR_8
REGS1_k127_1636161_1	643562.Daes_1976	5.217e-119	390.0	COG1915@1|root,COG1915@2|Bacteria,1R35F@1224|Proteobacteria,43DJ9@68525|delta/epsilon subdivisions,2X8QI@28221|Deltaproteobacteria,2M8W9@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM LOR SDH bifunctional enzyme conserved region	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_1636161_4	1121440.AUMA01000005_gene2577	9.236e-57	201.0	COG0615@1|root,COG2870@1|root,COG0615@2|Bacteria,COG2870@2|Bacteria,1R7DJ@1224|Proteobacteria,4321W@68525|delta/epsilon subdivisions,2WWR1@28221|Deltaproteobacteria,2M9G9@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose	-	-	-	-	-	-	-	-	-	-	-	-	CTP_transf_like,PfkB
REGS1_k127_1636161_5	156889.Mmc1_1062	6.73e-30	124.0	COG0615@1|root,COG2870@1|root,COG0615@2|Bacteria,COG2870@2|Bacteria,1R7DJ@1224|Proteobacteria,2VF2S@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose	-	-	-	-	-	-	-	-	-	-	-	-	CTP_transf_like,PfkB
REGS1_k127_1651418_2	1157490.EL26_10435	7.696e-16	82.0	COG2204@1|root,COG2204@2|Bacteria,1V6R9@1239|Firmicutes,4HIXH@91061|Bacilli,27AT9@186823|Alicyclobacillaceae	91061|Bacilli	T	cheY-homologous receiver domain	spo0F	-	-	ko:K02490	ko02020,ko02024,map02020,map02024	M00485	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg
REGS1_k127_1651418_1	243231.GSU1615	4.585e-107	364.0	COG0526@1|root,COG0526@2|Bacteria,1MWDE@1224|Proteobacteria,42RCT@68525|delta/epsilon subdivisions,2WKJ9@28221|Deltaproteobacteria,43UJX@69541|Desulfuromonadales	28221|Deltaproteobacteria	CO	COG0526, thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	Glutaredoxin
REGS1_k127_1651418_0	237368.SCABRO_01611	7.17e-194	608.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,2IYDT@203682|Planctomycetes	203682|Planctomycetes	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	-	-	-	-	-	-	-	-	-	-	-	-	EKR,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C
REGS1_k127_1658836_2	479431.Namu_3036	2.118e-09	62.0	COG3152@1|root,COG3152@2|Bacteria,2GSS4@201174|Actinobacteria	201174|Actinobacteria	S	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_1658836_0	1121918.ARWE01000001_gene685	5.949e-40	158.0	2ENGF@1|root,33G3Y@2|Bacteria,1P8WT@1224|Proteobacteria,43261@68525|delta/epsilon subdivisions,2WXJG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_1658836_1	867900.Celly_2282	1.661e-38	152.0	COG1047@1|root,COG1047@2|Bacteria,4NM29@976|Bacteroidetes,1I1ZU@117743|Flavobacteriia,1F9DH@104264|Cellulophaga	976|Bacteroidetes	G	COGs COG1047 FKBP-type peptidyl-prolyl cis-trans isomerase 2	slyD	-	5.2.1.8	ko:K01802,ko:K03774,ko:K03775	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C
REGS1_k127_1663975_1	1158756.AQXQ01000012_gene2036	1.033e-69	251.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	nirF	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	1.7.2.1,1.7.99.1	ko:K15864,ko:K19345	ko00910,ko01120,map00910,map01120	M00529	R00143,R00783,R00785	RC00086,RC02797	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytochrom_D1,Cytochrome_CBB3
REGS1_k127_1663975_6	1123376.AUIU01000019_gene1288	1.736e-15	82.0	28U9C@1|root,2ZGEW@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_1663975_0	290397.Adeh_2106	2.463e-114	376.0	COG0053@1|root,COG0053@2|Bacteria,1MUDS@1224|Proteobacteria,42NCJ@68525|delta/epsilon subdivisions,2WM7V@28221|Deltaproteobacteria,2Z1U0@29|Myxococcales	28221|Deltaproteobacteria	P	Dimerisation domain of Zinc Transporter	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
REGS1_k127_1663975_3	237368.SCABRO_03569	7.207e-23	102.0	29WUZ@1|root,30IGG@2|Bacteria,2J4C2@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_1663975_4	247490.KSU1_C1594	7.943e-18	86.0	2A5W3@1|root,30UMY@2|Bacteria,2J4MS@203682|Planctomycetes	203682|Planctomycetes	S	Domain of unknown function (DUF1858)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1858
REGS1_k127_1663975_7	401526.TcarDRAFT_0849	4.165e-05	46.0	COG1149@1|root,COG1149@2|Bacteria,1VUEG@1239|Firmicutes,4H522@909932|Negativicutes	909932|Negativicutes	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_1663975_2	748449.Halha_0709	1.574e-58	213.0	COG0648@1|root,COG0648@2|Bacteria,1TP1D@1239|Firmicutes,2499E@186801|Clostridia,3WABN@53433|Halanaerobiales	186801|Clostridia	L	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin	nfo	-	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
REGS1_k127_1663975_5	671143.DAMO_1183	8.735e-18	89.0	COG1669@1|root,COG1669@2|Bacteria	2|Bacteria	S	nucleotidyltransferase activity	-	-	-	ko:K07075	-	-	-	-	ko00000	-	-	-	DUF86,NTP_transf_2
REGS1_k127_1666867_0	443143.GM18_4329	0.0	1273.0	COG2373@1|root,COG2373@2|Bacteria,1MV7J@1224|Proteobacteria,42MJ8@68525|delta/epsilon subdivisions,2WIVP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Large extracellular alpha-helical protein	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,MG1,Thiol-ester_cl
REGS1_k127_1667933_3	247490.KSU1_C1575	8.559e-84	287.0	COG4191@1|root,COG4191@2|Bacteria,2IZWU@203682|Planctomycetes	203682|Planctomycetes	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg
REGS1_k127_1667933_6	247490.KSU1_C1576	8.395e-40	151.0	COG2204@1|root,COG3829@1|root,COG2204@2|Bacteria,COG3829@2|Bacteria,2J2D8@203682|Planctomycetes	203682|Planctomycetes	KT	Sigma-54 interaction domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,PAS_10,PAS_4,Response_reg,Sigma54_activat
REGS1_k127_1667933_2	443143.GM18_4008	3.098e-90	312.0	COG0642@1|root,COG0745@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42R7Z@68525|delta/epsilon subdivisions,2WN0B@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	PFAM ATP-binding region, ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_9,Response_reg
REGS1_k127_1667933_1	443143.GM18_0072	1.9e-103	341.0	COG2204@1|root,COG2204@2|Bacteria,1QWDW@1224|Proteobacteria	1224|Proteobacteria	T	Pfam Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
REGS1_k127_1667933_5	1121918.ARWE01000001_gene3199	1.376e-69	246.0	COG2199@1|root,COG2202@1|root,COG4191@1|root,COG5002@1|root,COG2202@2|Bacteria,COG3706@2|Bacteria,COG4191@2|Bacteria,COG5002@2|Bacteria,1RCM9@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_8,PAS_9,Response_reg
REGS1_k127_1667933_4	1121918.ARWE01000001_gene3199	1.412e-79	293.0	COG2199@1|root,COG2202@1|root,COG4191@1|root,COG5002@1|root,COG2202@2|Bacteria,COG3706@2|Bacteria,COG4191@2|Bacteria,COG5002@2|Bacteria,1RCM9@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_8,PAS_9,Response_reg
REGS1_k127_1667933_7	443143.GM18_4007	2.34e-39	151.0	COG0745@1|root,COG0745@2|Bacteria,1RD7E@1224|Proteobacteria,43BPD@68525|delta/epsilon subdivisions,2X70Q@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	PFAM response regulator receiver	-	-	-	ko:K11443	ko02020,ko04112,map02020,map04112	M00511	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg
REGS1_k127_1667933_8	243231.GSU2542	1.088e-05	51.0	2ES19@1|root,33JKA@2|Bacteria,1NJ84@1224|Proteobacteria,42X3J@68525|delta/epsilon subdivisions,2WSS2@28221|Deltaproteobacteria,43VSI@69541|Desulfuromonadales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_1667933_0	909663.KI867150_gene1368	6.369e-128	417.0	COG0539@1|root,COG0539@2|Bacteria,1N2EJ@1224|Proteobacteria,42NXS@68525|delta/epsilon subdivisions,2WJ0A@28221|Deltaproteobacteria,2MRA1@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Ribosomal protein S1-like RNA-binding domain	-	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
REGS1_k127_1669245_0	589865.DaAHT2_0550	3.909e-127	415.0	COG0303@1|root,COG0303@2|Bacteria,1QUKM@1224|Proteobacteria,42NTF@68525|delta/epsilon subdivisions,2X75Q@28221|Deltaproteobacteria,2MITK@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Probable molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	MoCF_biosynth
REGS1_k127_1669245_2	1158318.ATXC01000001_gene235	1.171e-06	52.0	COG5428@1|root,COG5428@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF2283)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2283
REGS1_k127_1728241_0	555779.Dthio_PD3229	3.015e-184	584.0	COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,42SPZ@68525|delta/epsilon subdivisions,2WIV9@28221|Deltaproteobacteria,2M8TZ@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
REGS1_k127_1728241_1	555779.Dthio_PD3230	4.09e-160	510.0	COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,43BP2@68525|delta/epsilon subdivisions,2WK8X@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	molybdopterin oxidoreductase Fe4S4 region	sfrA	-	1.17.1.10	ko:K05299	ko00680,ko00720,ko01100,ko01120,ko01200,map00680,map00720,map01100,map01120,map01200	M00377	R00134	RC02796	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_4,Fer4_10,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
REGS1_k127_1728241_2	1304880.JAGB01000001_gene619	1.931e-67	231.0	COG1894@1|root,COG1894@2|Bacteria,1TQB0@1239|Firmicutes,2483E@186801|Clostridia	186801|Clostridia	C	Respiratory-chain NADH dehydrogenase domain 51 kDa subunit	hymB	-	1.12.1.3,1.17.1.11,1.6.5.3	ko:K00335,ko:K18331,ko:K22339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
REGS1_k127_1745346_1	717231.Flexsi_0412	8.959e-89	299.0	COG1271@1|root,COG1271@2|Bacteria,2GF7E@200930|Deferribacteres	200930|Deferribacteres	C	Cytochrome bd terminal oxidase subunit I	-	-	1.10.3.14	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_I
REGS1_k127_1745346_0	269799.Gmet_1929	8.969e-146	470.0	COG1294@1|root,COG1294@2|Bacteria,1MURP@1224|Proteobacteria,42NHN@68525|delta/epsilon subdivisions,2WJ4S@28221|Deltaproteobacteria,43TP0@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	TIGRFAM cytochrome d ubiquinol oxidase, subunit II	cydB	-	1.10.3.14	ko:K00426	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_II
REGS1_k127_1745346_2	589865.DaAHT2_0174	5.112e-40	152.0	COG1959@1|root,COG1959@2|Bacteria,1MZ1C@1224|Proteobacteria,42SPF@68525|delta/epsilon subdivisions,2WPVC@28221|Deltaproteobacteria,2MM91@213118|Desulfobacterales	28221|Deltaproteobacteria	K	TIGRFAM transcriptional regulator, Rrf2 family	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
REGS1_k127_1745346_3	443144.GM21_1881	5.805e-20	94.0	COG1314@1|root,COG1314@2|Bacteria	2|Bacteria	U	P-P-bond-hydrolysis-driven protein transmembrane transporter activity	secG	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0022857,GO:0022884,GO:0031522,GO:0032978,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0042886,GO:0042887,GO:0043952,GO:0044464,GO:0045047,GO:0045184,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680	-	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecG
REGS1_k127_1752563_2	289376.THEYE_A1837	6.406e-59	209.0	COG0127@1|root,COG0127@2|Bacteria,3J0ST@40117|Nitrospirae	40117|Nitrospirae	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	rdgB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
REGS1_k127_1752563_3	269799.Gmet_1218	1.418e-53	207.0	COG2202@1|root,COG4191@1|root,COG2202@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42NFR@68525|delta/epsilon subdivisions,2X7KX@28221|Deltaproteobacteria,43T3C@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,PAS_4
REGS1_k127_1752563_1	398767.Glov_3521	1.424e-140	460.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria	1224|Proteobacteria	T	Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains	-	-	-	ko:K02481,ko:K11384	ko02020,map02020	M00505	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
REGS1_k127_1752563_5	909663.KI867150_gene1899	6.111e-38	145.0	COG0745@1|root,COG0745@2|Bacteria,1RHDD@1224|Proteobacteria,42SAC@68525|delta/epsilon subdivisions,2WP7J@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	PFAM response regulator receiver	cheY34H-1	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
REGS1_k127_1752563_6	1122226.AUHX01000007_gene2688	4.781e-14	77.0	COG2204@1|root,COG2204@2|Bacteria,4NE89@976|Bacteroidetes,1HWWK@117743|Flavobacteriia	976|Bacteroidetes	T	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	zraR	-	-	ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
REGS1_k127_1752563_4	909663.KI867150_gene1899	7.124e-49	179.0	COG0745@1|root,COG0745@2|Bacteria,1RHDD@1224|Proteobacteria,42SAC@68525|delta/epsilon subdivisions,2WP7J@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	PFAM response regulator receiver	cheY34H-1	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
REGS1_k127_1752563_0	243231.GSU1290	6.155e-157	511.0	COG0643@1|root,COG0643@2|Bacteria,1MUAG@1224|Proteobacteria,42M6Q@68525|delta/epsilon subdivisions,2WJ5U@28221|Deltaproteobacteria,43S4S@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Signal transducing histidine kinase homodimeric	cheA34H	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt
REGS1_k127_1765553_5	269799.Gmet_3382	5.441e-70	254.0	COG5000@1|root,COG5002@1|root,COG5000@2|Bacteria,COG5002@2|Bacteria,1QTV1@1224|Proteobacteria,43BSP@68525|delta/epsilon subdivisions,2X7EK@28221|Deltaproteobacteria,43W43@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	histidine kinase, HAMP	-	-	2.7.13.3	ko:K07642	ko02020,map02020	M00450,M00645,M00646,M00648	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
REGS1_k127_1765553_4	945713.IALB_0152	1.097e-77	265.0	COG0745@1|root,COG0745@2|Bacteria	945713.IALB_0152|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_1765553_6	1121403.AUCV01000001_gene737	2.047e-48	178.0	COG0680@1|root,COG0680@2|Bacteria,1RE1C@1224|Proteobacteria,42REH@68525|delta/epsilon subdivisions,2WP4D@28221|Deltaproteobacteria,2MKC0@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Hydrogenase maturation protease	hybD	-	-	ko:K03605	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	HycI
REGS1_k127_1765553_0	1121403.AUCV01000054_gene2604	8.577e-242	754.0	COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,42M4S@68525|delta/epsilon subdivisions,2WJQS@28221|Deltaproteobacteria,2MI12@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Belongs to the NiFe NiFeSe hydrogenase large subunit family	hynA	-	1.12.2.1,1.12.5.1,1.12.99.6	ko:K00437,ko:K05922,ko:K06281	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
REGS1_k127_1765553_7	1123372.AUIT01000003_gene845	1.837e-34	132.0	COG0374@1|root,COG0374@2|Bacteria,2GH4N@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	C	Nickel-dependent hydrogenase	-	-	1.12.99.6	ko:K06281	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
REGS1_k127_1765553_2	1121403.AUCV01000054_gene2603	2.441e-121	400.0	COG5557@1|root,COG5557@2|Bacteria,1MWYI@1224|Proteobacteria,42PH3@68525|delta/epsilon subdivisions,2WJZH@28221|Deltaproteobacteria,2MIN0@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Polysulphide reductase, NrfD	-	-	-	-	-	-	-	-	-	-	-	-	NrfD
REGS1_k127_1765553_3	1121403.AUCV01000054_gene2605	2.145e-117	386.0	COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,42S59@68525|delta/epsilon subdivisions,2WNGW@28221|Deltaproteobacteria,2MPWP@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	hybA	-	-	-	-	-	-	-	-	-	-	-	Fer4_11,Fer4_4,TAT_signal
REGS1_k127_1765553_1	1121403.AUCV01000054_gene2606	8.157e-156	500.0	COG1740@1|root,COG1740@2|Bacteria,1MWAC@1224|Proteobacteria,42MI0@68525|delta/epsilon subdivisions,2WIW4@28221|Deltaproteobacteria,2MJ8Z@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Hydrogenase (NiFe) small subunit HydA	hynB	-	1.12.2.1,1.12.5.1,1.12.99.6	ko:K05927,ko:K06282,ko:K18008	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFe_hyd_SSU_C,Oxidored_q6,TAT_signal
REGS1_k127_1765553_8	523791.Kkor_1288	6.155e-12	70.0	COG2010@1|root,COG2010@2|Bacteria,1RFJV@1224|Proteobacteria,1S4GY@1236|Gammaproteobacteria,1XPKF@135619|Oceanospirillales	135619|Oceanospirillales	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
REGS1_k127_1765553_9	45351.EDO28397	0.0003959	49.0	COG0642@1|root,KOG0519@2759|Eukaryota	2759|Eukaryota	T	phosphorelay sensor kinase activity	-	-	2.7.13.3	ko:K19691	ko02020,map02020	M00516	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	GAF,HATPase_c,HisKA,PAS,PAS_3,Response_reg
REGS1_k127_17664_0	1121405.dsmv_2974	1.917e-241	750.0	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,42MGK@68525|delta/epsilon subdivisions,2X5GV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	EF	Carbamoyl-phosphate synthetase large chain, oligomerisation domain	-	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
REGS1_k127_17664_3	879212.DespoDRAFT_01355	0.000222	48.0	2AT6X@1|root,31IPI@2|Bacteria,1RHW1@1224|Proteobacteria,42SHT@68525|delta/epsilon subdivisions,2WP67@28221|Deltaproteobacteria,2MK8G@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_17664_2	909663.KI867150_gene1546	1.396e-14	79.0	2EQZT@1|root,33IJD@2|Bacteria,1NKTX@1224|Proteobacteria,42XNG@68525|delta/epsilon subdivisions,2WTCK@28221|Deltaproteobacteria,2MQPM@213462|Syntrophobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_17664_1	1125863.JAFN01000001_gene3501	5.62e-37	150.0	COG0739@1|root,COG0739@2|Bacteria,1MY2X@1224|Proteobacteria,42U06@68525|delta/epsilon subdivisions,2WP2C@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	PFAM Peptidase M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
REGS1_k127_1770738_6	289376.THEYE_A1948	1.177e-31	124.0	COG0205@1|root,COG0205@2|Bacteria,3J0Y1@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	-	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
REGS1_k127_1770738_0	289376.THEYE_A1945	3.297e-193	612.0	COG0191@1|root,COG0191@2|Bacteria,3J0WJ@40117|Nitrospirae	40117|Nitrospirae	G	Fructose-bisphosphate aldolase class-II	-	-	-	-	-	-	-	-	-	-	-	-	F_bP_aldolase
REGS1_k127_1770738_3	1499967.BAYZ01000154_gene1483	2e-57	210.0	2CKE1@1|root,32T5C@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_1770738_5	247490.KSU1_C0388	7.472e-48	175.0	COG0432@1|root,COG0432@2|Bacteria,2J0R1@203682|Planctomycetes	203682|Planctomycetes	S	PFAM Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
REGS1_k127_1770738_2	926692.AZYG01000040_gene1541	1.916e-58	215.0	COG1663@1|root,COG1663@2|Bacteria,1TWGA@1239|Firmicutes,24HYU@186801|Clostridia,3WAME@53433|Halanaerobiales	186801|Clostridia	M	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)	lpxK	-	2.7.1.130	ko:K00912	ko00540,ko01100,map00540,map01100	M00060	R04657	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxK
REGS1_k127_1770738_9	1121459.AQXE01000005_gene1506	0.00036	52.0	2AKQ6@1|root,31BGX@2|Bacteria,1RCS3@1224|Proteobacteria,43CF4@68525|delta/epsilon subdivisions,2X855@28221|Deltaproteobacteria,2M9YM@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	TIGRFAM MJ0042 family finger-like protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3426,zinc_ribbon_4
REGS1_k127_1770738_7	485913.Krac_8476	3.99e-19	93.0	COG3794@1|root,COG3794@2|Bacteria,2G7GX@200795|Chloroflexi	200795|Chloroflexi	C	Copper binding proteins, plastocyanin/azurin family	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cupredoxin_1
REGS1_k127_1770738_1	589865.DaAHT2_2430	2.598e-177	563.0	COG1902@1|root,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,42NA7@68525|delta/epsilon subdivisions,2WIN5@28221|Deltaproteobacteria,2MJ30@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM NADH flavin oxidoreductase NADH oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN
REGS1_k127_1770738_4	1499967.BAYZ01000009_gene5260	6.634e-56	203.0	2AY4N@1|root,31Q6J@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_1783492_0	243231.GSU0547	2.677e-250	795.0	COG1193@1|root,COG1193@2|Bacteria,1QUJI@1224|Proteobacteria,42P7P@68525|delta/epsilon subdivisions,2WK5H@28221|Deltaproteobacteria,43U0Y@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity	mutS2	-	-	ko:K07456	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_V,Smr
REGS1_k127_1783492_5	290315.Clim_0353	2.088e-86	288.0	COG0503@1|root,COG0503@2|Bacteria,1FE1Q@1090|Chlorobi	1090|Chlorobi	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	apt	-	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
REGS1_k127_1783492_2	9668.ENSMPUP00000015872	1.008e-93	314.0	COG0005@1|root,KOG3985@2759|Eukaryota,38GVK@33154|Opisthokonta,3BF5F@33208|Metazoa,3CS6F@33213|Bilateria,4813S@7711|Chordata,490J1@7742|Vertebrata,3J1QQ@40674|Mammalia,3EUQW@33554|Carnivora	33208|Metazoa	F	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates	MTAP	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004645,GO:0004731,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006555,GO:0006725,GO:0006790,GO:0006807,GO:0007154,GO:0007165,GO:0007166,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0010033,GO:0016053,GO:0016740,GO:0016757,GO:0016758,GO:0016763,GO:0017061,GO:0017144,GO:0019221,GO:0019509,GO:0019752,GO:0023052,GO:0032259,GO:0034097,GO:0034641,GO:0035722,GO:0042221,GO:0043094,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070671,GO:0070887,GO:0071265,GO:0071267,GO:0071310,GO:0071345,GO:0071349,GO:0071704,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
REGS1_k127_1783492_3	1123376.AUIU01000001_gene791	3.944e-93	311.0	COG0378@1|root,COG0378@2|Bacteria,3J128@40117|Nitrospirae	40117|Nitrospirae	KO	CobW/HypB/UreG, nucleotide-binding domain	hypB	-	-	ko:K04652	-	-	-	-	ko00000,ko03110	-	-	-	cobW
REGS1_k127_1783492_7	289376.THEYE_A1390	8.238e-32	128.0	COG0375@1|root,COG0375@2|Bacteria	2|Bacteria	S	nickel cation binding	hypA	-	-	ko:K04651,ko:K19640	-	-	-	-	ko00000,ko02022,ko03110	-	-	-	HypA
REGS1_k127_1783492_8	909663.KI867150_gene1792	7.084e-24	107.0	COG4980@1|root,COG4980@2|Bacteria,1NB49@1224|Proteobacteria,42W0M@68525|delta/epsilon subdivisions,2WRVH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	YtxH-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YtxH
REGS1_k127_1783492_1	289376.THEYE_A1298	8.144e-134	436.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,3J0H2@40117|Nitrospirae	40117|Nitrospirae	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	ribD	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
REGS1_k127_1783492_4	589865.DaAHT2_0980	1.246e-87	299.0	COG0837@1|root,COG0837@2|Bacteria,1MVFI@1224|Proteobacteria,42RJH@68525|delta/epsilon subdivisions,2WP0R@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Belongs to the bacterial glucokinase family	glk	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucokinase
REGS1_k127_1783492_6	880072.Desac_0702	9.172e-55	198.0	COG1751@1|root,COG1751@2|Bacteria,1NERB@1224|Proteobacteria,42W3N@68525|delta/epsilon subdivisions,2WS20@28221|Deltaproteobacteria,2MS0Q@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	PFAM Pyruvate kinase, alpha beta domain	-	-	-	ko:K09126	-	-	-	-	ko00000	-	-	-	PK_C
REGS1_k127_1783532_0	289376.THEYE_A0718	3.595e-176	567.0	COG0007@1|root,COG1587@1|root,COG0007@2|Bacteria,COG1587@2|Bacteria,3J0B6@40117|Nitrospirae	40117|Nitrospirae	H	Belongs to the precorrin methyltransferase family	-	-	2.1.1.107,4.2.1.75	ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165,R03194	RC00003,RC00871,RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4,TP_methylase
REGS1_k127_1783532_1	765913.ThidrDRAFT_2857	3.078e-44	175.0	COG1199@1|root,COG1199@2|Bacteria,1MVCU@1224|Proteobacteria,1RMNX@1236|Gammaproteobacteria,1WWG0@135613|Chromatiales	135613|Chromatiales	L	Helicase	-	-	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,Helicase_C_2
REGS1_k127_1810508_1	243231.GSU2656	1.667e-152	491.0	COG0508@1|root,COG0508@2|Bacteria,1MU7K@1224|Proteobacteria,42MYB@68525|delta/epsilon subdivisions,2WIUY@28221|Deltaproteobacteria,43TUD@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	e3 binding domain	bkdF	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
REGS1_k127_1810508_0	338966.Ppro_1589	5.393e-162	521.0	COG1042@1|root,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,42KZW@68525|delta/epsilon subdivisions,2WIQB@28221|Deltaproteobacteria,43TJ2@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	CoA binding domain	-	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
REGS1_k127_1810508_2	1167006.UWK_03283	2.049e-27	119.0	COG3448@1|root,COG3448@2|Bacteria,1Q1A8@1224|Proteobacteria,42SIQ@68525|delta/epsilon subdivisions,2WPF0@28221|Deltaproteobacteria,2MKBJ@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
REGS1_k127_1821801_1	243231.GSU1989	2.053e-121	396.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42Z13@68525|delta/epsilon subdivisions,2WTMT@28221|Deltaproteobacteria,43UA4@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
REGS1_k127_1821801_0	1232410.KI421414_gene2877	2.686e-158	523.0	COG1086@1|root,COG1086@2|Bacteria,1MWKY@1224|Proteobacteria,42MMR@68525|delta/epsilon subdivisions,2WJEB@28221|Deltaproteobacteria,43TVP@69541|Desulfuromonadales	28221|Deltaproteobacteria	GM	Polysaccharide biosynthesis protein CapD	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding_3,Polysacc_synt_2
REGS1_k127_1821801_3	330214.NIDE0886	5.588e-62	220.0	COG2148@1|root,COG2148@2|Bacteria	2|Bacteria	M	undecaprenyl-phosphate glucose phosphotransferase activity	bplG	-	-	-	-	-	-	-	-	-	-	-	Bac_transf
REGS1_k127_1821801_2	204536.SULAZ_0355	1.915e-105	349.0	COG0399@1|root,COG0399@2|Bacteria,2G4VK@200783|Aquificae	200783|Aquificae	E	Cys/Met metabolism PLP-dependent enzyme	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
REGS1_k127_1822952_1	880073.Calab_2035	3.372e-105	348.0	COG0543@1|root,COG0543@2|Bacteria,2NNUA@2323|unclassified Bacteria	2|Bacteria	CH	Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B	gltA	-	1.18.1.2,1.19.1.1,1.4.1.13,1.4.1.14	ko:K00266,ko:K00528,ko:K02823	ko00240,ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00240,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248,R10159	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	DHODB_Fe-S_bind,Fer4_20,NAD_binding_1,Pyr_redox_2
REGS1_k127_1822952_0	56780.SYN_00606	9.493e-131	422.0	COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,42MGY@68525|delta/epsilon subdivisions,2WJHC@28221|Deltaproteobacteria,2MREN@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	TIGRFAM glutamate synthase (NADPH), homotetrameric	-	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
REGS1_k127_1862348_0	1123371.ATXH01000001_gene1239	1.02e-180	585.0	COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,2GHHP@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	GT	Pyruvate phosphate dikinase, PEP/pyruvate binding domain	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
REGS1_k127_1862348_1	1123376.AUIU01000004_gene1151	4.302e-60	210.0	COG0021@1|root,COG0021@2|Bacteria,3J0MM@40117|Nitrospirae	40117|Nitrospirae	G	Transketolase, pyrimidine binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
REGS1_k127_1883684_1	877455.Metbo_1412	1.506e-63	242.0	COG0642@1|root,COG0784@1|root,arCOG02348@1|root,arCOG06712@1|root,arCOG02348@2157|Archaea,arCOG02393@2157|Archaea,arCOG06192@2157|Archaea,arCOG06712@2157|Archaea,2Y7RQ@28890|Euryarchaeota	28890|Euryarchaeota	T	ATP-binding region, ATPase domain protein domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA_2,PAS_3,PAS_9,Response_reg
REGS1_k127_1883684_0	671143.DAMO_2651	5.469e-274	858.0	COG0021@1|root,COG0021@2|Bacteria,2NS3T@2323|unclassified Bacteria	2|Bacteria	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	tkt	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
REGS1_k127_1883684_2	547144.HydHO_1080	3.576e-15	77.0	COG0425@1|root,COG0425@2|Bacteria	2|Bacteria	O	sulfur carrier activity	-	-	-	ko:K04085	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DrsE,TusA
REGS1_k127_1889365_3	552398.HMPREF0866_02313	4.085e-79	274.0	COG0410@1|root,COG0410@2|Bacteria,1TPW4@1239|Firmicutes,247PN@186801|Clostridia,3WHG1@541000|Ruminococcaceae	186801|Clostridia	E	ABC transporter, ATP-binding protein	livF1	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
REGS1_k127_1889365_2	2045.KR76_11610	3.402e-79	272.0	COG0411@1|root,COG0411@2|Bacteria,2GMEE@201174|Actinobacteria,4DPPJ@85009|Propionibacteriales	201174|Actinobacteria	E	Amino acid amide ABC transporter ATP-binding protein 1, HAAT family	livG	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
REGS1_k127_1889365_0	671143.DAMO_1396	3.287e-96	327.0	COG0411@1|root,COG4177@1|root,COG0411@2|Bacteria,COG4177@2|Bacteria,2NNYG@2323|unclassified Bacteria	2|Bacteria	E	Branched-chain amino acid ATP-binding cassette transporter	livM	GO:0003333,GO:0003674,GO:0005215,GO:0005304,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015173,GO:0015175,GO:0015179,GO:0015188,GO:0015192,GO:0015238,GO:0015318,GO:0015658,GO:0015711,GO:0015801,GO:0015803,GO:0015804,GO:0015807,GO:0015818,GO:0015823,GO:0015829,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:1902475,GO:1903714,GO:1903785,GO:1903825,GO:1905039	-	ko:K01995,ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	iPC815.YPO3806,iSDY_1059.SDY_3605	ABC_tran,BCA_ABC_TP_C,BPD_transp_2,DUF3382
REGS1_k127_1889365_1	671143.DAMO_1397	9.813e-86	288.0	COG0559@1|root,COG0559@2|Bacteria,2NP7Z@2323|unclassified Bacteria	2|Bacteria	E	Branched-chain amino acid transport system / permease component	livH	GO:0003333,GO:0003674,GO:0005215,GO:0005304,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015173,GO:0015175,GO:0015179,GO:0015188,GO:0015190,GO:0015192,GO:0015238,GO:0015318,GO:0015658,GO:0015711,GO:0015801,GO:0015803,GO:0015804,GO:0015807,GO:0015818,GO:0015820,GO:0015823,GO:0015829,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0043090,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0089718,GO:0098655,GO:0098656,GO:0098657,GO:0098713,GO:0098739,GO:1902475,GO:1903714,GO:1903785,GO:1903825,GO:1905039	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	iJN746.PP_4866,iSFV_1184.SFV_3460,iSF_1195.SF3475,iSFxv_1172.SFxv_3791,iS_1188.S4288	BPD_transp_2
REGS1_k127_1901217_4	457570.Nther_1645	1.014e-46	172.0	COG0251@1|root,COG0251@2|Bacteria,1V6G4@1239|Firmicutes,24IS7@186801|Clostridia	186801|Clostridia	J	translation initiation inhibitor, yjgF family	-	-	-	-	-	-	-	-	-	-	-	-	YjgF_endoribonc
REGS1_k127_1901217_2	316067.Geob_1539	5.555e-73	250.0	COG0066@1|root,COG0066@2|Bacteria,1MVXB@1224|Proteobacteria,42RR2@68525|delta/epsilon subdivisions,2WNPQ@28221|Deltaproteobacteria,43TIT@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1269	Aconitase_C
REGS1_k127_1901217_0	443143.GM18_2603	8.301e-229	713.0	COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,42M5D@68525|delta/epsilon subdivisions,2WJ59@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
REGS1_k127_1901217_3	1415779.JOMH01000001_gene2821	1.336e-60	220.0	COG0583@1|root,COG0583@2|Bacteria,1NSNV@1224|Proteobacteria,1RPNG@1236|Gammaproteobacteria,1X5G3@135614|Xanthomonadales	135614|Xanthomonadales	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
REGS1_k127_1901217_1	880072.Desac_0564	4.233e-125	408.0	COG0730@1|root,COG0730@2|Bacteria,1PYDH@1224|Proteobacteria,42P28@68525|delta/epsilon subdivisions,2WK6D@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
REGS1_k127_1901217_5	1123376.AUIU01000018_gene29	2.918e-45	175.0	COG0622@1|root,COG0622@2|Bacteria	2|Bacteria	S	retrograde transport, endosome to Golgi	-	-	-	ko:K07095	-	-	-	-	ko00000	-	-	-	DinB_2,Metallophos_2
REGS1_k127_1906005_0	913325.N799_00650	0.0	1103.0	COG1002@1|root,COG1002@2|Bacteria,1MWRH@1224|Proteobacteria,1RRRA@1236|Gammaproteobacteria,1X4J5@135614|Xanthomonadales	135614|Xanthomonadales	V	Type II restriction enzyme, methylase	-	-	-	-	-	-	-	-	-	-	-	-	N6_Mtase
REGS1_k127_1906005_2	572546.Arcpr_1033	2.172e-69	244.0	COG0327@1|root,arCOG04454@2157|Archaea,2XT5G@28890|Euryarchaeota,246Y5@183980|Archaeoglobi	183980|Archaeoglobi	S	NIF3 (NGG1p interacting factor 3)	-	-	-	-	-	-	-	-	-	-	-	-	NIF3
REGS1_k127_1906005_1	289376.THEYE_A0317	5.203e-113	379.0	COG0457@1|root,COG1066@1|root,COG5416@1|root,COG0457@2|Bacteria,COG1066@2|Bacteria,COG5416@2|Bacteria,3J1FE@40117|Nitrospirae	40117|Nitrospirae	O	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_1906005_4	316067.Geob_0611	4.762e-35	138.0	COG1576@1|root,COG1576@2|Bacteria,1N7WB@1224|Proteobacteria,42V41@68525|delta/epsilon subdivisions,2X6IT@28221|Deltaproteobacteria,43UX0@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA	rlmH	-	2.1.1.177	ko:K00783	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SPOUT_MTase
REGS1_k127_1906005_5	1120973.AQXL01000135_gene1480	1.944e-30	125.0	COG0799@1|root,COG0799@2|Bacteria,1VA2Z@1239|Firmicutes,4HKEJ@91061|Bacilli,278I1@186823|Alicyclobacillaceae	91061|Bacilli	J	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation	rsfS	GO:0003674,GO:0005488,GO:0006417,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0043021,GO:0043023,GO:0044087,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:0090069,GO:0090071,GO:2000112,GO:2000113	-	ko:K09710	-	-	-	-	ko00000,ko03009	-	-	-	RsfS
REGS1_k127_1906005_3	289376.THEYE_A0791	2.569e-50	186.0	COG1057@1|root,COG1057@2|Bacteria,3J0T3@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	-	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
REGS1_k127_1925514_3	289376.THEYE_A1479	4.628e-20	90.0	COG0333@1|root,COG0333@2|Bacteria	2|Bacteria	J	Belongs to the bacterial ribosomal protein bL32 family	rpmF	GO:0000027,GO:0000302,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006950,GO:0006979,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042221,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1901700,GO:1990904	-	ko:K02911	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_L32p
REGS1_k127_1925514_1	289376.THEYE_A1478	4.903e-127	414.0	COG0416@1|root,COG0416@2|Bacteria,3J0DY@40117|Nitrospirae	40117|Nitrospirae	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA	plsX	-	2.3.1.15	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_synthesis
REGS1_k127_1925514_0	289376.THEYE_A1477	4.696e-131	425.0	COG0332@1|root,COG0332@2|Bacteria,3J0FW@40117|Nitrospirae	40117|Nitrospirae	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
REGS1_k127_1925514_2	335543.Sfum_2268	2.541e-70	242.0	COG0398@1|root,COG0398@2|Bacteria,1QKZU@1224|Proteobacteria,42SRQ@68525|delta/epsilon subdivisions,2WP35@28221|Deltaproteobacteria,2MQG7@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	PFAM SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
REGS1_k127_1950055_0	706587.Desti_0512	5.863e-58	206.0	COG1607@1|root,COG1607@2|Bacteria,1RAEQ@1224|Proteobacteria,42SPA@68525|delta/epsilon subdivisions,2WPPE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	PFAM thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
REGS1_k127_1950055_1	886293.Sinac_0386	9.987e-48	182.0	COG1555@1|root,COG1555@2|Bacteria	2|Bacteria	L	photosystem II stabilization	comEA	-	-	ko:K02237	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	HHH_3,SLBB
REGS1_k127_1950055_2	269799.Gmet_1680	3.552e-29	119.0	2CFNS@1|root,331AJ@2|Bacteria,1NBYG@1224|Proteobacteria,42VZ5@68525|delta/epsilon subdivisions,2WR8A@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_1950055_3	159087.Daro_3855	0.0005401	43.0	COG3753@1|root,COG3753@2|Bacteria,1N7FF@1224|Proteobacteria,2VVTK@28216|Betaproteobacteria,2KZ92@206389|Rhodocyclales	206389|Rhodocyclales	S	Bacterial protein of unknown function (DUF937)	-	-	-	-	-	-	-	-	-	-	-	-	DUF937
REGS1_k127_2015198_3	1304885.AUEY01000015_gene2987	1.942e-13	72.0	COG4464@1|root,COG4464@2|Bacteria,1R5E2@1224|Proteobacteria,42UBJ@68525|delta/epsilon subdivisions,2WQ5M@28221|Deltaproteobacteria,2MKG9@213118|Desulfobacterales	28221|Deltaproteobacteria	GM	PFAM PHP domain protein	-	-	3.1.3.48	ko:K01104	-	-	-	-	ko00000,ko01000	-	-	-	-
REGS1_k127_2015198_1	289376.THEYE_A1527	8.65e-69	240.0	COG0546@1|root,COG0546@2|Bacteria	2|Bacteria	S	glycolate biosynthetic process	gph1	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD,HAD_2,Hydrolase_like
REGS1_k127_2015198_0	1123376.AUIU01000011_gene1116	3.448e-80	277.0	COG0190@1|root,COG0190@2|Bacteria,3J0FT@40117|Nitrospirae	40117|Nitrospirae	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
REGS1_k127_2015198_2	247490.KSU1_B0227	5.779e-23	100.0	COG2336@1|root,COG2336@2|Bacteria	2|Bacteria	T	PFAM SpoVT AbrB	mazE	-	-	ko:K07172,ko:K18842	-	-	-	-	ko00000,ko02048	-	-	-	MazE_antitoxin
REGS1_k127_2042960_1	690850.Desaf_0206	6.283e-08	61.0	COG3166@1|root,COG3166@2|Bacteria,1PD1G@1224|Proteobacteria,42UEP@68525|delta/epsilon subdivisions,2WR1V@28221|Deltaproteobacteria,2MF5A@213115|Desulfovibrionales	28221|Deltaproteobacteria	NU	Fimbrial assembly protein (PilN)	-	-	-	ko:K02461	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	PilM_2,PilN
REGS1_k127_2042960_0	671143.DAMO_2479	7.05e-66	243.0	COG1450@1|root,COG1450@2|Bacteria,2NQ01@2323|unclassified Bacteria	2|Bacteria	NU	Bacterial type II and III secretion system protein	gspD	-	-	ko:K02453,ko:K03219	ko03070,ko05111,map03070,map05111	M00331,M00332,M00542	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15,3.A.6.1,3.A.6.3	-	-	Secretin,Secretin_N
REGS1_k127_2052091_3	1261545.MBE-HAL_1391	1.197e-11	68.0	COG1378@1|root,arCOG02038@2157|Archaea,2XTR7@28890|Euryarchaeota,23RWX@183963|Halobacteria	183963|Halobacteria	K	Transcriptional regulators	trmB	-	-	-	-	-	-	-	-	-	-	-	Regulator_TrmB,TrmB
REGS1_k127_2052091_0	760142.Hipma_0943	2.428e-174	570.0	COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,42M04@68525|delta/epsilon subdivisions,2WJJD@28221|Deltaproteobacteria,2M6AE@213113|Desulfurellales	28221|Deltaproteobacteria	J	DALR_2	cysS	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e,tRNA-synt_1g
REGS1_k127_2052091_1	635013.TherJR_0273	1.336e-60	218.0	COG0566@1|root,COG0566@2|Bacteria,1TP9G@1239|Firmicutes,247SC@186801|Clostridia,2602K@186807|Peptococcaceae	186801|Clostridia	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	yacO	-	2.1.1.185	ko:K03218	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SpoU_methylase,SpoU_sub_bind
REGS1_k127_2052091_5	717785.HYPMC_1707	5.945e-06	49.0	2DGHW@1|root,2ZW1T@2|Bacteria,1P867@1224|Proteobacteria,2UWAZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Evidence 5 No homology to any previously reported sequences	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_2052091_4	1461580.CCAS010000015_gene1842	1.373e-06	50.0	2AWWM@1|root,31NU5@2|Bacteria,1TZQ8@1239|Firmicutes,4II4F@91061|Bacilli,1ZJ4J@1386|Bacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_2052091_2	1123229.AUBC01000041_gene3825	4.284e-18	83.0	COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,2TQP8@28211|Alphaproteobacteria,3JRYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
REGS1_k127_2064269_3	1499967.BAYZ01000181_gene4488	6.593e-13	71.0	COG1514@1|root,COG1514@2|Bacteria,2NPRT@2323|unclassified Bacteria	2|Bacteria	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	ligT	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008104,GO:0008150,GO:0009966,GO:0010646,GO:0010738,GO:0023051,GO:0033036,GO:0034237,GO:0044424,GO:0044444,GO:0044464,GO:0048583,GO:0050789,GO:0050794,GO:0051018,GO:0051179,GO:0065007,GO:1902531	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
REGS1_k127_2064269_0	289376.THEYE_A0533	3.399e-156	500.0	COG0468@1|root,COG0468@2|Bacteria,3J0C1@40117|Nitrospirae	40117|Nitrospirae	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	-	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
REGS1_k127_2064269_1	404589.Anae109_3433	1.514e-155	499.0	COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,42M7F@68525|delta/epsilon subdivisions,2WJ28@28221|Deltaproteobacteria,2YWA0@29|Myxococcales	28221|Deltaproteobacteria	NU	Type II/IV secretion system protein	pilT-1	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
REGS1_k127_2064269_2	748449.Halha_1605	2.967e-13	76.0	COG2137@1|root,COG2137@2|Bacteria,1V72V@1239|Firmicutes,24KZH@186801|Clostridia,3WAVE@53433|Halanaerobiales	186801|Clostridia	S	Modulates RecA activity	recX	-	-	ko:K03565	-	-	-	-	ko00000,ko03400	-	-	-	RecX
REGS1_k127_2074503_0	1121472.AQWN01000003_gene1583	2.098e-86	299.0	COG2195@1|root,COG2195@2|Bacteria,1TP3A@1239|Firmicutes,248JJ@186801|Clostridia,26079@186807|Peptococcaceae	186801|Clostridia	E	TIGRFAM peptidase T-like protein	-	-	3.4.11.4	ko:K01258	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
REGS1_k127_2074503_2	742767.HMPREF9456_00001	0.0009127	49.0	COG0727@1|root,COG0727@2|Bacteria,4NJH9@976|Bacteroidetes,2FT9S@200643|Bacteroidia,22Y7M@171551|Porphyromonadaceae	976|Bacteroidetes	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
REGS1_k127_2074503_1	289376.THEYE_A0823	3.241e-31	125.0	COG0068@1|root,COG0068@2|Bacteria,3J0WS@40117|Nitrospirae	40117|Nitrospirae	O	Telomere recombination	hypF	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
REGS1_k127_21033_2	289376.THEYE_A1869	7.538e-15	76.0	COG2928@1|root,COG2928@2|Bacteria,3J0R2@40117|Nitrospirae	40117|Nitrospirae	S	Protein of unknown function (DUF502)	-	-	-	-	-	-	-	-	-	-	-	-	DUF502
REGS1_k127_21033_1	1123376.AUIU01000011_gene938	3.676e-130	430.0	COG1207@1|root,COG1207@2|Bacteria,3J0CG@40117|Nitrospirae	40117|Nitrospirae	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transf_3
REGS1_k127_21033_0	671143.DAMO_1991	2.823e-185	592.0	COG0449@1|root,COG0449@2|Bacteria,2NNWC@2323|unclassified Bacteria	2|Bacteria	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	iAF987.Gmet_1487	GATase_6,SIS
REGS1_k127_2115223_1	552811.Dehly_0758	8.186e-57	204.0	COG0784@1|root,COG0784@2|Bacteria	2|Bacteria	T	Response regulator, receiver	arcB_2	-	-	-	-	-	-	-	-	-	-	-	Response_reg
REGS1_k127_2115223_0	1220534.B655_0987	2.667e-93	333.0	arCOG02348@1|root,arCOG02348@2157|Archaea	2157|Archaea	T	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA_2,PAS,PAS_3,PAS_4,PAS_9,Response_reg
REGS1_k127_2115223_2	404380.Gbem_1487	8.963e-44	170.0	COG3221@1|root,COG3221@2|Bacteria,1MXD8@1224|Proteobacteria,42R3U@68525|delta/epsilon subdivisions,2WMPK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	phosphonate ABC transporter, periplasmic phosphonate binding protein	-	-	-	ko:K02044	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	Phosphonate-bd
REGS1_k127_2137089_2	857087.Metme_4169	0.0005002	48.0	COG3291@1|root,COG3656@1|root,COG3291@2|Bacteria,COG3656@2|Bacteria,1QXQ7@1224|Proteobacteria,1T3G4@1236|Gammaproteobacteria,1XGBG@135618|Methylococcales	135618|Methylococcales	M	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	REJ
REGS1_k127_2137089_0	760142.Hipma_1124	2.156e-51	196.0	2EH25@1|root,33AU4@2|Bacteria,1Q6QJ@1224|Proteobacteria,432AQ@68525|delta/epsilon subdivisions,2WXJV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_2137089_1	1112214.AHIS01000102_gene1545	5.563e-06	50.0	2ES5B@1|root,33JQ4@2|Bacteria,1NHPR@1224|Proteobacteria,2UN83@28211|Alphaproteobacteria,2K67H@204457|Sphingomonadales	204457|Sphingomonadales	S	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
REGS1_k127_2145775_7	105559.Nwat_2350	9.426e-26	112.0	COG1450@1|root,COG4796@1|root,COG1450@2|Bacteria,COG4796@2|Bacteria,1MUUA@1224|Proteobacteria,1RPJS@1236|Gammaproteobacteria,1WVZW@135613|Chromatiales	135613|Chromatiales	NU	Type II and III secretion system protein	-	-	-	ko:K02453	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	Secretin,Secretin_N
REGS1_k127_2145775_6	868131.MSWAN_0111	1.255e-33	132.0	COG0599@1|root,arCOG02148@2157|Archaea,2XXZ4@28890|Euryarchaeota	28890|Euryarchaeota	S	PFAM Carboxymuconolactone decarboxylase	-	-	-	-	-	-	-	-	-	-	-	-	CMD
REGS1_k127_2145775_9	946483.Cenrod_1489	2.238e-20	106.0	COG2831@1|root,COG3209@1|root,COG4964@1|root,COG2831@2|Bacteria,COG3209@2|Bacteria,COG4964@2|Bacteria,1MWWH@1224|Proteobacteria,2VU6Q@28216|Betaproteobacteria,4AFBU@80864|Comamonadaceae	28216|Betaproteobacteria	U	PFAM Ig domain protein, group 1 domain protein	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	-
REGS1_k127_2145775_0	289376.THEYE_A0946	2.73e-146	480.0	COG0241@1|root,COG0859@1|root,COG0241@2|Bacteria,COG0859@2|Bacteria,3J0PZ@40117|Nitrospirae	40117|Nitrospirae	EM	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	ko:K02843	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9,Hydrolase_like
REGS1_k127_2145775_3	1123376.AUIU01000014_gene614	4.73e-97	328.0	COG0859@1|root,COG0859@2|Bacteria,3J0KI@40117|Nitrospirae	40117|Nitrospirae	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	ko:K02841,ko:K02843	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
REGS1_k127_2145775_11	644282.Deba_2368	1.381e-06	54.0	2DP9Z@1|root,3316S@2|Bacteria,1R1CI@1224|Proteobacteria,42V8N@68525|delta/epsilon subdivisions,2X8FK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_2145775_5	589865.DaAHT2_0148	7.523e-44	166.0	COG0607@1|root,COG0607@2|Bacteria,1NN37@1224|Proteobacteria	1224|Proteobacteria	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
REGS1_k127_2145775_1	1123257.AUFV01000002_gene2395	1.086e-131	435.0	COG2391@1|root,COG2391@2|Bacteria,1PF9B@1224|Proteobacteria,1SH3M@1236|Gammaproteobacteria,1XBJT@135614|Xanthomonadales	135614|Xanthomonadales	S	Sulphur transport	-	-	-	-	-	-	-	-	-	-	-	-	Sulf_transp
REGS1_k127_2145775_8	396588.Tgr7_0064	2.737e-24	105.0	COG0425@1|root,COG0425@2|Bacteria,1QSN1@1224|Proteobacteria,1SS7P@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Belongs to the sulfur carrier protein TusA family	-	-	-	-	-	-	-	-	-	-	-	-	TusA
REGS1_k127_2145775_10	376733.IT41_10365	8.44e-11	71.0	COG0589@1|root,COG0589@2|Bacteria,1PR99@1224|Proteobacteria,2V3IN@28211|Alphaproteobacteria,2PYR4@265|Paracoccus	28211|Alphaproteobacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
REGS1_k127_2145775_4	65393.PCC7424_4196	4.742e-55	201.0	COG1232@1|root,COG1232@2|Bacteria,1G05M@1117|Cyanobacteria,3KGQ6@43988|Cyanothece	1117|Cyanobacteria	H	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
REGS1_k127_2152286_1	1123376.AUIU01000014_gene714	8.719e-60	218.0	COG0760@1|root,COG0760@2|Bacteria,3J16U@40117|Nitrospirae	40117|Nitrospirae	O	PPIC-type PPIASE domain	-	-	5.2.1.8	ko:K03769	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase_2,SurA_N_3
REGS1_k127_2152286_4	649349.Lbys_0432	2.103e-24	114.0	COG0732@1|root,COG0827@1|root,COG1002@1|root,COG0732@2|Bacteria,COG0827@2|Bacteria,COG1002@2|Bacteria,4NEHR@976|Bacteroidetes,47M22@768503|Cytophagia	976|Bacteroidetes	L	PFAM Eco57I restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Eco57I,TaqI_C
REGS1_k127_2152286_2	402777.KB235904_gene3331	7.058e-28	114.0	2FK9Q@1|root,34BXC@2|Bacteria,1GFFS@1117|Cyanobacteria,1HGBU@1150|Oscillatoriales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_2152286_3	32057.KB217478_gene3548	1.291e-27	113.0	COG5428@1|root,COG5428@2|Bacteria,1G8AS@1117|Cyanobacteria	1117|Cyanobacteria	S	Protein of unknown function (DUF2283)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2283
REGS1_k127_2152286_0	289376.THEYE_A1989	2.518e-239	754.0	COG0744@1|root,COG0744@2|Bacteria,3J1FP@40117|Nitrospirae	40117|Nitrospirae	M	Transglycosylase	-	-	2.4.1.129,3.4.16.4	ko:K05365,ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
REGS1_k127_2171851_1	1123376.AUIU01000011_gene973	1.921e-149	488.0	COG0265@1|root,COG0265@2|Bacteria,3J0VW@40117|Nitrospirae	40117|Nitrospirae	O	Trypsin	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
REGS1_k127_2171851_0	161156.JQKW01000014_gene237	8.725e-173	556.0	COG3604@1|root,COG3604@2|Bacteria,2GGRI@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	T	GAF domain	-	-	-	ko:K02584	ko02020,map02020	-	-	-	ko00000,ko00001,ko03000	-	-	-	GAF,GAF_2,HTH_8,Sigma54_activat
REGS1_k127_2205078_5	1313265.JNIE01000002_gene1065	3.19e-12	66.0	COG0780@1|root,COG0780@2|Bacteria,2G4AN@200783|Aquificae	200783|Aquificae	H	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)	queF	-	1.7.1.13	ko:K09457	ko00790,ko01100,map00790,map01100	-	R07605	RC01875	ko00000,ko00001,ko01000,ko03016	-	-	-	QueF
REGS1_k127_2205078_4	338966.Ppro_1292	2.656e-65	233.0	COG0135@1|root,COG0135@2|Bacteria,1RA87@1224|Proteobacteria,42QQ3@68525|delta/epsilon subdivisions,2WNPH@28221|Deltaproteobacteria,43U0C@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Belongs to the TrpF family	trpF	-	5.3.1.24	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03509	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	PRAI
REGS1_k127_2205078_0	289376.THEYE_A0084	7.386e-226	707.0	COG1350@1|root,COG1350@2|Bacteria,3J1FC@40117|Nitrospirae	40117|Nitrospirae	E	Pyridoxal-phosphate dependent enzyme	-	-	4.2.1.20	ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
REGS1_k127_2205078_2	944481.JAFP01000001_gene1380	5.641e-69	243.0	COG1327@1|root,COG1327@2|Bacteria,1NVQW@1224|Proteobacteria,430GP@68525|delta/epsilon subdivisions,2WW5K@28221|Deltaproteobacteria,2M6VJ@213113|Desulfurellales	28221|Deltaproteobacteria	K	ATP cone domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-cone,Mrr_cat
REGS1_k127_2205078_1	1123499.KB908030_gene559	9.588e-119	389.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,2VJI3@28216|Betaproteobacteria,2KPYW@206351|Neisseriales	206351|Neisseriales	E	Belongs to the cysteine synthase cystathionine beta- synthase family	cysK	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
REGS1_k127_2205078_3	1337936.IJ00_02975	3.532e-66	252.0	COG0142@1|root,COG5621@1|root,COG0142@2|Bacteria,COG5621@2|Bacteria,1G3K9@1117|Cyanobacteria	1117|Cyanobacteria	H	Lipocalin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CrtC,Lipocalin_9,polyprenyl_synt
REGS1_k127_2213807_1	1121422.AUMW01000002_gene2106	3.237e-54	194.0	COG0822@1|root,COG0822@2|Bacteria,1V3H9@1239|Firmicutes,24HDD@186801|Clostridia,261QI@186807|Peptococcaceae	186801|Clostridia	C	FeS cluster assembly scaffold protein NifU	nifU	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
REGS1_k127_2213807_0	515635.Dtur_0719	7.028e-128	420.0	COG1104@1|root,COG1104@2|Bacteria	2|Bacteria	E	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
REGS1_k127_2213807_3	747365.Thena_0211	3.152e-22	99.0	COG0425@1|root,COG0425@2|Bacteria,1UF14@1239|Firmicutes,25K1R@186801|Clostridia,42IV0@68295|Thermoanaerobacterales	186801|Clostridia	O	Sulfurtransferase TusA	-	-	-	-	-	-	-	-	-	-	-	-	TusA
REGS1_k127_2213807_2	161156.JQKW01000007_gene653	1.105e-40	155.0	COG1959@1|root,COG1959@2|Bacteria,2GGXM@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
REGS1_k127_2217345_2	1121396.KB893060_gene2849	1.389e-46	193.0	COG3852@1|root,COG3852@2|Bacteria,1NTTH@1224|Proteobacteria,42MC9@68525|delta/epsilon subdivisions,2WIYS@28221|Deltaproteobacteria,2MHU3@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	2.7.13.3	ko:K07709	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS_4,PAS_9,sCache_3_2
REGS1_k127_2217345_0	484770.UFO1_2557	3.591e-85	293.0	COG2201@1|root,COG2201@2|Bacteria,1TRHC@1239|Firmicutes,4H2ES@909932|Negativicutes	909932|Negativicutes	NT	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	cheB	-	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,Response_reg
REGS1_k127_2217345_3	404380.Gbem_0746	4.333e-32	139.0	COG1413@1|root,COG1413@2|Bacteria,1N55Z@1224|Proteobacteria,42Q7F@68525|delta/epsilon subdivisions,2WPWV@28221|Deltaproteobacteria,43UH8@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	HEAT repeat	-	-	-	-	-	-	-	-	-	-	-	-	HEAT,HEAT_2,HEAT_PBS
REGS1_k127_2217345_1	316067.Geob_3381	1.787e-56	207.0	COG1352@1|root,COG1352@2|Bacteria,1MU6W@1224|Proteobacteria,42QPJ@68525|delta/epsilon subdivisions	1224|Proteobacteria	H	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP	cheR1	-	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheR,CheR_N
REGS1_k127_2217345_4	635013.TherJR_0123	2.169e-24	110.0	COG0840@1|root,COG5278@1|root,COG0840@2|Bacteria,COG5278@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia,261EY@186807|Peptococcaceae	186801|Clostridia	NT	histidine kinase HAMP region domain protein	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,CHASE3,HAMP,MCPsignal,dCache_1
REGS1_k127_2228453_0	289376.THEYE_A1491	4.565e-209	691.0	COG2203@1|root,COG3829@1|root,COG3852@1|root,COG2203@2|Bacteria,COG3829@2|Bacteria,COG3852@2|Bacteria,3J0YT@40117|Nitrospirae	40117|Nitrospirae	T	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_9
REGS1_k127_2228453_2	289376.THEYE_A1490	3.277e-46	169.0	COG0745@1|root,COG0745@2|Bacteria	289376.THEYE_A1490|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_2228453_1	1123325.JHUV01000011_gene1553	5.717e-54	202.0	COG2265@1|root,COG2265@2|Bacteria,2G3V7@200783|Aquificae	200783|Aquificae	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	rumA	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	tRNA_U5-meth_tr
REGS1_k127_2246631_2	1336243.JAEA01000001_gene1768	5.611e-11	63.0	COG1278@1|root,COG1278@2|Bacteria,1QW5N@1224|Proteobacteria,2U8SB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Sigma 54 modulation protein / S30EA ribosomal protein	-	-	-	-	-	-	-	-	-	-	-	-	CSD,Ribosomal_S30AE
REGS1_k127_2246631_0	926560.KE387023_gene2277	1.267e-27	113.0	COG4309@1|root,COG4309@2|Bacteria,1WKCP@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Uncharacterized conserved protein (DUF2249)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2249
REGS1_k127_2246631_3	289376.THEYE_A0789	9.636e-10	63.0	COG1141@1|root,COG1141@2|Bacteria	2|Bacteria	C	electron transfer activity	-	-	-	ko:K05337,ko:K17247	-	-	-	-	ko00000	-	-	-	Fer4_13,Ferric_reduct
REGS1_k127_2246631_1	1121918.ARWE01000001_gene2220	3.834e-12	75.0	COG0745@1|root,COG0745@2|Bacteria,1QZ5N@1224|Proteobacteria,4307W@68525|delta/epsilon subdivisions,2X7RC@28221|Deltaproteobacteria,43UV3@69541|Desulfuromonadales	28221|Deltaproteobacteria	KT	PilZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PilZ,Response_reg
REGS1_k127_2248304_3	717231.Flexsi_0152	3.359e-11	67.0	COG1917@1|root,COG1917@2|Bacteria	2|Bacteria	L	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
REGS1_k127_2248304_2	563192.HMPREF0179_02304	2.971e-15	76.0	COG1146@1|root,COG1146@2|Bacteria,1QWQ4@1224|Proteobacteria,43BUY@68525|delta/epsilon subdivisions,2X75X@28221|Deltaproteobacteria,2MHB0@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_7
REGS1_k127_2248304_0	1123376.AUIU01000011_gene934	1.128e-78	266.0	COG0461@1|root,COG0461@2|Bacteria,3J0T8@40117|Nitrospirae	40117|Nitrospirae	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
REGS1_k127_2248304_1	298655.KI912267_gene7479	1.601e-44	173.0	COG1391@1|root,COG1391@2|Bacteria,2GJ91@201174|Actinobacteria,4ERDC@85013|Frankiales	201174|Actinobacteria	H	Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell	glnE	GO:0000820,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006521,GO:0008150,GO:0008882,GO:0010565,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0030312,GO:0031323,GO:0033238,GO:0040007,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0060359,GO:0062012,GO:0065007,GO:0070566,GO:0071944,GO:0080090,GO:1901698	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
REGS1_k127_2255660_0	1123376.AUIU01000004_gene1150	1.669e-133	439.0	COG0568@1|root,COG0568@2|Bacteria,3J0E4@40117|Nitrospirae	40117|Nitrospirae	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
REGS1_k127_2255660_2	323261.Noc_1096	6.813e-44	161.0	COG1359@1|root,COG1359@2|Bacteria,1N1AN@1224|Proteobacteria,1S750@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_2255660_1	1163617.SCD_n02200	6.425e-120	398.0	COG3267@1|root,COG3409@1|root,COG3267@2|Bacteria,COG3409@2|Bacteria,1MU3G@1224|Proteobacteria,2VIK1@28216|Betaproteobacteria	28216|Betaproteobacteria	U	SMART AAA ATPase	exeA	-	-	ko:K02450	-	M00331	-	-	ko00000,ko00002,ko02044	9.B.42	-	-	AAA_22,PG_binding_1
REGS1_k127_2255660_3	1121918.ARWE01000001_gene2828	1.068e-17	91.0	COG5373@1|root,COG5373@2|Bacteria,1QZY0@1224|Proteobacteria,42XBF@68525|delta/epsilon subdivisions,2WSP1@28221|Deltaproteobacteria,43VT6@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Type II secretion system protein B	-	-	-	ko:K02451	-	M00331	-	-	ko00000,ko00002,ko02044	9.B.42	-	-	T2SSB
REGS1_k127_2268302_2	795359.TOPB45_1242	9.882e-52	194.0	COG0589@1|root,COG0589@2|Bacteria,2GHQN@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	T	PFAM UspA	-	-	-	-	-	-	-	-	-	-	-	-	Usp
REGS1_k127_2268302_1	335543.Sfum_0645	1.402e-83	284.0	2C5J8@1|root,30F9Z@2|Bacteria,1RE16@1224|Proteobacteria,42RYB@68525|delta/epsilon subdivisions,2WNIF@28221|Deltaproteobacteria,2MRTU@213462|Syntrophobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_2268302_0	644968.DFW101_3614	8.089e-110	359.0	COG0730@1|root,COG0730@2|Bacteria,1MWX2@1224|Proteobacteria,42MRE@68525|delta/epsilon subdivisions,2WIP0@28221|Deltaproteobacteria,2M81I@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
REGS1_k127_2270128_1	648996.Theam_0736	1.438e-88	296.0	COG1894@1|root,COG1894@2|Bacteria,2G3V6@200783|Aquificae	200783|Aquificae	C	PFAM Respiratory-chain NADH dehydrogenase domain 51 kDa subunit	nuoF	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
REGS1_k127_2270128_2	1191523.MROS_0156	6.685e-39	152.0	COG1905@1|root,COG1905@2|Bacteria	2|Bacteria	C	2 iron, 2 sulfur cluster binding	nuoE	-	1.6.5.3	ko:K00334,ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
REGS1_k127_2270128_0	289376.THEYE_A0914	5.025e-139	449.0	COG0649@1|root,COG0649@2|Bacteria,3J0FM@40117|Nitrospirae	40117|Nitrospirae	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	-	1.6.5.3	ko:K00333,ko:K13378	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa,NiFeSe_Hases
REGS1_k127_2313591_0	243231.GSU0522	1.248e-150	485.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,42MGZ@68525|delta/epsilon subdivisions,2WIY6@28221|Deltaproteobacteria,43TW5@69541|Desulfuromonadales	28221|Deltaproteobacteria	JKL	DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA	rhlB	-	3.6.4.13	ko:K03732	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03019	-	-	-	DEAD,Helicase_C,R3H
REGS1_k127_2313591_1	243274.THEMA_06140	1.914e-11	68.0	COG0584@1|root,COG0584@2|Bacteria,2GD9A@200918|Thermotogae	200918|Thermotogae	C	PFAM Glycerophosphoryl diester phosphodiesterase	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
REGS1_k127_2318627_2	1254432.SCE1572_28445	1.925e-38	151.0	28H8R@1|root,2Z7KJ@2|Bacteria,1Q390@1224|Proteobacteria,43905@68525|delta/epsilon subdivisions,2X457@28221|Deltaproteobacteria,2YYAC@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_2318627_0	880073.Calab_0981	1.499e-80	280.0	COG0628@1|root,COG0628@2|Bacteria,2NPYJ@2323|unclassified Bacteria	2|Bacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
REGS1_k127_2318627_1	880073.Calab_0980	6.178e-43	163.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
REGS1_k127_2324403_2	316067.Geob_1015	8.576e-61	214.0	2EE9W@1|root,3384B@2|Bacteria,1NCE1@1224|Proteobacteria,42VUH@68525|delta/epsilon subdivisions,2WSA1@28221|Deltaproteobacteria,43V30@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Menaquinol oxidoreductase complex Cbc4, cytochrome c subunit	cbcS	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_c3_2,Cytochrome_C554,Paired_CXXCH_1
REGS1_k127_2324403_1	269799.Gmet_3519	1.1e-139	447.0	COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,42QZ2@68525|delta/epsilon subdivisions,2WMS4@28221|Deltaproteobacteria,43T2N@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	cbcT	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_11,Fer4_2,Fer4_3,Fer4_7
REGS1_k127_2324403_0	243231.GSU0070	9.369e-198	623.0	COG4881@1|root,COG4881@2|Bacteria,1QXMX@1224|Proteobacteria,43C41@68525|delta/epsilon subdivisions,2WKYD@28221|Deltaproteobacteria,43TBN@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Polysulphide reductase, NrfD	cbcU	-	-	-	-	-	-	-	-	-	-	-	NrfD
REGS1_k127_2324403_5	1123376.AUIU01000011_gene960	1.127e-23	106.0	COG3381@1|root,COG3381@2|Bacteria	2|Bacteria	S	protein complex oligomerization	-	-	-	-	-	-	-	-	-	-	-	-	Nitrate_red_del
REGS1_k127_2324403_6	1121406.JAEX01000023_gene1471	7.425e-09	61.0	COG5336@1|root,COG5336@2|Bacteria,1NHIS@1224|Proteobacteria,42WTD@68525|delta/epsilon subdivisions,2WSRU@28221|Deltaproteobacteria,2MDF1@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter	atpZ	-	-	ko:K02116	-	-	-	-	ko00000,ko00194	3.A.2.1	-	-	ATPase_gene1
REGS1_k127_2324403_3	436114.SYO3AOP1_1085	1.411e-35	142.0	COG1573@1|root,COG1573@2|Bacteria,2G41P@200783|Aquificae	200783|Aquificae	L	TIGRFAM Phage SPO1 DNA polymerase-related protein	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
REGS1_k127_2328458_4	909663.KI867150_gene185	6.4e-66	229.0	COG1871@1|root,COG1871@2|Bacteria,1RDDB@1224|Proteobacteria,42S9S@68525|delta/epsilon subdivisions,2WNSD@28221|Deltaproteobacteria,2MQQV@213462|Syntrophobacterales	28221|Deltaproteobacteria	NT	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis	cheD2	-	3.5.1.44	ko:K03411	ko02030,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheD
REGS1_k127_2328458_0	247490.KSU1_D1053	1.985e-152	493.0	COG0501@1|root,COG0501@2|Bacteria,2J0GY@203682|Planctomycetes	203682|Planctomycetes	O	CAAX prenyl protease N-terminal, five membrane helices	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48,Peptidase_M48_N
REGS1_k127_2328458_8	1123371.ATXH01000023_gene938	2.542e-11	65.0	2ED51@1|root,3371S@2|Bacteria,2GIK1@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_2328458_1	289376.THEYE_A1958	8.456e-125	406.0	COG0107@1|root,COG0107@2|Bacteria,3J0GV@40117|Nitrospirae	40117|Nitrospirae	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
REGS1_k127_2328458_3	289376.THEYE_A1955	8.748e-79	275.0	COG0106@1|root,COG0106@2|Bacteria,3J0KA@40117|Nitrospirae	40117|Nitrospirae	E	Histidine biosynthesis protein	hisA	GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
REGS1_k127_2328458_5	316067.Geob_0675	5.371e-64	227.0	COG3170@1|root,COG3170@2|Bacteria,1REZ7@1224|Proteobacteria,42RFW@68525|delta/epsilon subdivisions,2WS8K@28221|Deltaproteobacteria,43VBZ@69541|Desulfuromonadales	28221|Deltaproteobacteria	NU	Protein of unknown function (DUF3108)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3108
REGS1_k127_2328458_2	380749.HY04AAS1_0831	7.968e-117	392.0	COG1086@1|root,COG2148@1|root,COG1086@2|Bacteria,COG2148@2|Bacteria,2G3XH@200783|Aquificae	200783|Aquificae	M	sugar transferase	-	-	2.7.8.6	ko:K00996	-	-	-	-	ko00000,ko01000,ko01005	-	-	-	Bac_transf,CoA_binding_3
REGS1_k127_2328458_6	243233.MCA2561	3.227e-62	223.0	COG1216@1|root,COG4942@1|root,COG1216@2|Bacteria,COG4942@2|Bacteria,1MX5Z@1224|Proteobacteria	1224|Proteobacteria	J	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tran_WbsX,Glyco_transf_4,Glycos_transf_1,Glycos_transf_2
REGS1_k127_2329225_0	289376.THEYE_A0706	2.74e-114	378.0	COG0249@1|root,COG0249@2|Bacteria,3J0CE@40117|Nitrospirae	40117|Nitrospirae	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
REGS1_k127_2329225_1	338966.Ppro_2064	8.283e-110	357.0	28HB2@1|root,2Z7N8@2|Bacteria,1P4RV@1224|Proteobacteria,42NVF@68525|delta/epsilon subdivisions,2WKNV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Fatty acid cis/trans isomerase (CTI)	-	-	-	-	-	-	-	-	-	-	-	-	CTI
REGS1_k127_2359373_2	1235792.C808_04044	0.0005261	46.0	2E11F@1|root,32WHB@2|Bacteria,1VD34@1239|Firmicutes,24J9R@186801|Clostridia,27PD4@186928|unclassified Lachnospiraceae	186801|Clostridia	S	PilZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PilZ
REGS1_k127_2359373_0	1123376.AUIU01000011_gene1054	5.744e-67	241.0	COG1463@1|root,COG1463@2|Bacteria,3J164@40117|Nitrospirae	40117|Nitrospirae	Q	MlaD protein	-	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
REGS1_k127_2367097_0	314230.DSM3645_11616	6.388e-166	531.0	COG0448@1|root,COG0448@2|Bacteria,2IXP5@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
REGS1_k127_2367097_3	269799.Gmet_2313	2.77e-39	160.0	COG0745@1|root,COG0745@2|Bacteria,1N9YT@1224|Proteobacteria,42W15@68525|delta/epsilon subdivisions,2WS2V@28221|Deltaproteobacteria,43T56@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	regulator, PATAN and FRGAF domain-containing	-	-	-	-	-	-	-	-	-	-	-	-	DUF4388,Response_reg
REGS1_k127_2367097_4	243231.GSU2223	1.151e-38	147.0	COG0745@1|root,COG0745@2|Bacteria,1N1TA@1224|Proteobacteria,42V03@68525|delta/epsilon subdivisions,2WPZR@28221|Deltaproteobacteria,43V4S@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	PFAM response regulator receiver	cheY40H-1	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
REGS1_k127_2367097_1	316067.Geob_2159	9.021e-165	540.0	COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,42M6Q@68525|delta/epsilon subdivisions,2WJ5U@28221|Deltaproteobacteria,43S5Y@69541|Desulfuromonadales	28221|Deltaproteobacteria	NT	Signal transducing histidine kinase homodimeric	cheA40H	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt
REGS1_k127_2367097_2	443143.GM18_3609	1.792e-39	149.0	COG3267@1|root,COG3267@2|Bacteria,1REY9@1224|Proteobacteria,42RJB@68525|delta/epsilon subdivisions,2WN99@28221|Deltaproteobacteria,43TEB@69541|Desulfuromonadales	28221|Deltaproteobacteria	U	Pfam:Arch_ATPase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22
REGS1_k127_2383404_7	1336241.JAEB01000008_gene1004	1.514e-13	75.0	COG0212@1|root,COG0212@2|Bacteria,1VA91@1239|Firmicutes,24N7H@186801|Clostridia,25WW2@186806|Eubacteriaceae	186801|Clostridia	H	5-formyltetrahydrofolate cyclo-ligase	fthC	-	6.3.3.2	ko:K01934	ko00670,ko01100,map00670,map01100	-	R02301	RC00183	ko00000,ko00001,ko01000	-	-	-	5-FTHF_cyc-lig
REGS1_k127_2383404_5	2325.TKV_c20090	2.189e-91	307.0	COG3640@1|root,COG3640@2|Bacteria,1TPCY@1239|Firmicutes,247JM@186801|Clostridia,42F6P@68295|Thermoanaerobacterales	186801|Clostridia	D	CO dehydrogenase	cooC	-	-	ko:K07321	-	-	-	-	ko00000	-	-	-	CbiA
REGS1_k127_2383404_3	909663.KI867150_gene1470	3.911e-99	336.0	COG1237@1|root,COG1237@2|Bacteria,1NK2I@1224|Proteobacteria,42QRA@68525|delta/epsilon subdivisions,2WN1V@28221|Deltaproteobacteria,2MQMM@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	2.5.1.105	ko:K06897	ko00790,map00790	-	R10339	RC00121	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
REGS1_k127_2383404_1	289376.THEYE_A0671	1.822e-160	517.0	COG4992@1|root,COG4992@2|Bacteria,3J0AB@40117|Nitrospirae	40117|Nitrospirae	E	Aminotransferase class-III	argD	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
REGS1_k127_2383404_2	289376.THEYE_A0670	5.154e-110	363.0	COG0078@1|root,COG0078@2|Bacteria,3J0G7@40117|Nitrospirae	40117|Nitrospirae	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	-	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
REGS1_k127_2383404_4	671143.DAMO_1593	1.099e-91	313.0	COG3437@1|root,COG3437@2|Bacteria,2NPBP@2323|unclassified Bacteria	2|Bacteria	T	HD domain	-	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	HD,HD_5,Response_reg
REGS1_k127_2383404_0	314345.SPV1_02432	2.916e-188	629.0	COG0642@1|root,COG2199@1|root,COG2205@2|Bacteria,COG3706@2|Bacteria,1NRP8@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,GAF_2,HAMP,HATPase_c,HisKA,MASE4,PAS,PAS_3,PAS_9,Response_reg,dCache_1
REGS1_k127_2383404_6	1356854.N007_06865	2.668e-48	174.0	COG0595@1|root,COG0595@2|Bacteria,1TQ9G@1239|Firmicutes,4HAAP@91061|Bacilli,277WB@186823|Alicyclobacillaceae	91061|Bacilli	S	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay	rnj	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,RMMBL
REGS1_k127_2387431_2	880072.Desac_1220	1.06e-60	223.0	COG0589@1|root,COG0589@2|Bacteria,1RA7K@1224|Proteobacteria,42V2P@68525|delta/epsilon subdivisions,2WR88@28221|Deltaproteobacteria,2MSCK@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
REGS1_k127_2387431_0	1123368.AUIS01000031_gene1418	1.717e-164	524.0	COG0730@1|root,COG0730@2|Bacteria,1MWX2@1224|Proteobacteria,1T8C8@1236|Gammaproteobacteria,2NCKI@225057|Acidithiobacillales	225057|Acidithiobacillales	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
REGS1_k127_2387431_4	795359.TOPB45_1244	2.097e-18	88.0	2EGXE@1|root,33APK@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_2387431_1	795359.TOPB45_1248	3.07e-135	444.0	COG2204@1|root,COG2204@2|Bacteria,2GH05@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	T	Two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
REGS1_k127_2387431_3	667014.Thein_2063	7.68e-37	145.0	COG4191@1|root,COG4191@2|Bacteria,2GIGP@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
REGS1_k127_2445942_0	1163617.SCD_n00935	3.34e-124	408.0	COG1352@1|root,COG2201@1|root,COG1352@2|Bacteria,COG2201@2|Bacteria,1NQTI@1224|Proteobacteria	1224|Proteobacteria	NT	Chemotaxis	-	-	2.1.1.80,3.1.1.61	ko:K13924	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,CheR,CheR_N,HWE_HK,PAS,PAS_10,PAS_4
REGS1_k127_2445942_1	316067.Geob_3659	1.428e-46	175.0	COG1215@1|root,COG1215@2|Bacteria,1PC79@1224|Proteobacteria,42QYP@68525|delta/epsilon subdivisions,2X6HG@28221|Deltaproteobacteria,43UDX@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Glycosyl transferase family group 2	hpnI	-	2.4.1.80	ko:K00720	ko00600,ko01100,map00600,map01100	M00066	R01497	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko02000	4.D.1.4	GT21	-	Glyco_transf_21
REGS1_k127_2449658_0	748247.AZKH_1490	6.799e-206	658.0	COG1680@1|root,COG3876@1|root,COG1680@2|Bacteria,COG3876@2|Bacteria,1MX3S@1224|Proteobacteria,2VMMF@28216|Betaproteobacteria,2KXTY@206389|Rhodocyclales	206389|Rhodocyclales	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,DUF1343
REGS1_k127_2449658_1	380394.Lferr_1829	9.56e-149	482.0	COG1306@1|root,COG1306@2|Bacteria,1MWBY@1224|Proteobacteria,1SMIH@1236|Gammaproteobacteria,2NDMU@225057|Acidithiobacillales	225057|Acidithiobacillales	S	Putative glycosyl hydrolase domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4015
REGS1_k127_2449658_2	316067.Geob_1672	1.566e-103	342.0	COG0726@1|root,COG0726@2|Bacteria,1MWUE@1224|Proteobacteria,42QSJ@68525|delta/epsilon subdivisions,2WQ2V@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	PFAM Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
REGS1_k127_2449658_4	644282.Deba_0346	4.649e-05	48.0	COG1360@1|root,COG1360@2|Bacteria,1MU4S@1224|Proteobacteria,42Q7D@68525|delta/epsilon subdivisions,2WN6T@28221|Deltaproteobacteria	28221|Deltaproteobacteria	N	PFAM OmpA MotB domain protein	-	-	-	ko:K02557	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotB_plug,OmpA
REGS1_k127_2449658_3	1121918.ARWE01000001_gene401	3.832e-31	128.0	COG1762@1|root,COG1762@2|Bacteria,1RG0Z@1224|Proteobacteria,42RSF@68525|delta/epsilon subdivisions,2WNXB@28221|Deltaproteobacteria,43TNV@69541|Desulfuromonadales	28221|Deltaproteobacteria	GT	Helix-turn-helix domain	-	-	-	ko:K02806	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	HTH_17,PTS_EIIA_2
REGS1_k127_2468092_2	573370.DMR_17110	1.113e-100	334.0	COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,42M5V@68525|delta/epsilon subdivisions,2WIR6@28221|Deltaproteobacteria,2M92B@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine	nifS-1	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
REGS1_k127_2468092_1	1125863.JAFN01000001_gene2666	1.333e-104	348.0	COG0694@1|root,COG0822@1|root,COG0694@2|Bacteria,COG0822@2|Bacteria,1RD5K@1224|Proteobacteria,42MT6@68525|delta/epsilon subdivisions,2WJBU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	CO	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins	nifU	-	-	ko:K13819	-	-	-	-	ko00000	-	-	-	Fer2_BFD,NifU,NifU_N
REGS1_k127_2468092_5	289376.THEYE_A1821	1.024e-36	140.0	COG4274@1|root,COG4274@2|Bacteria	2|Bacteria	S	GYD domain	-	-	-	-	-	-	-	-	-	-	-	-	GYD
REGS1_k127_2468092_8	608538.HTH_1886	2.949e-25	107.0	COG0425@1|root,COG0425@2|Bacteria	2|Bacteria	O	sulfur carrier activity	-	-	-	ko:K04085	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DrsE,TusA
REGS1_k127_2468092_10	1120963.KB894496_gene2675	4.551e-08	55.0	2DS85@1|root,33EYM@2|Bacteria,1NJQN@1224|Proteobacteria,1SHH9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_2468092_4	443143.GM18_4487	3.692e-38	155.0	COG2897@1|root,COG2897@2|Bacteria,1QQTJ@1224|Proteobacteria,43A4S@68525|delta/epsilon subdivisions,2WUSF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	SMART Rhodanese domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
REGS1_k127_2468092_14	713586.KB900536_gene2198	2.824e-05	51.0	COG2897@1|root,COG2897@2|Bacteria	2|Bacteria	P	thiosulfate sulfurtransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
REGS1_k127_2468092_0	589865.DaAHT2_2441	3.676e-126	415.0	COG3746@1|root,COG3746@2|Bacteria,1QXPF@1224|Proteobacteria,42TW0@68525|delta/epsilon subdivisions,2WQ4G@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	PFAM Phosphate-selective porin O and P	-	-	-	-	-	-	-	-	-	-	-	-	Porin_O_P
REGS1_k127_2468092_3	443143.GM18_3762	9.231e-58	205.0	COG2165@1|root,COG2165@2|Bacteria,1RDX2@1224|Proteobacteria,42SFB@68525|delta/epsilon subdivisions,2WP3B@28221|Deltaproteobacteria	28221|Deltaproteobacteria	U	general secretion pathway protein G	gspG	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSG
REGS1_k127_2468092_9	443144.GM21_0604	9.556e-23	104.0	COG4970@1|root,COG4970@2|Bacteria,1NA3K@1224|Proteobacteria,42XEU@68525|delta/epsilon subdivisions,2WSX4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	U	Prokaryotic N-terminal methylation motif	gspH	-	-	ko:K02457	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl
REGS1_k127_2468092_12	1121918.ARWE01000001_gene732	2.425e-06	55.0	COG4967@1|root,COG4967@2|Bacteria,1PSVT@1224|Proteobacteria,43EXX@68525|delta/epsilon subdivisions,2X2IT@28221|Deltaproteobacteria,43VM1@69541|Desulfuromonadales	28221|Deltaproteobacteria	NU	Prokaryotic N-terminal methylation motif	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl
REGS1_k127_2468092_7	316067.Geob_0890	3.075e-26	115.0	COG4795@1|root,COG4795@2|Bacteria,1NPEC@1224|Proteobacteria,42WZG@68525|delta/epsilon subdivisions,2WSPB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	U	Type II secretion system (T2SS), protein J	gspJ	-	-	ko:K02459	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSJ
REGS1_k127_2468092_6	443144.GM21_0601	5.604e-30	130.0	COG3156@1|root,COG3156@2|Bacteria,1N9I4@1224|Proteobacteria,42V0N@68525|delta/epsilon subdivisions,2WRR8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	U	PFAM General secretion pathway protein K	gspK	-	-	ko:K02460	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSK
REGS1_k127_2468092_13	1278073.MYSTI_02888	5.109e-06	55.0	COG4972@1|root,COG4972@2|Bacteria,1MYIB@1224|Proteobacteria,42SIX@68525|delta/epsilon subdivisions,2WP1G@28221|Deltaproteobacteria,2YVKD@29|Myxococcales	28221|Deltaproteobacteria	NU	Type IV pilus assembly protein PilM;	gspL	-	-	ko:K02461	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	GspL_C,PilM_2,PilN,T2SSL
REGS1_k127_2477987_2	289376.THEYE_A1796	1.173e-09	62.0	COG0124@1|root,COG0124@2|Bacteria,3J0EC@40117|Nitrospirae	40117|Nitrospirae	J	Histidyl-tRNA synthetase	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
REGS1_k127_2477987_0	387631.Asulf_01024	2.477e-35	147.0	COG2855@1|root,arCOG03873@2157|Archaea	2157|Archaea	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	Cons_hypoth698
REGS1_k127_2477987_1	646529.Desaci_1723	5.085e-13	81.0	COG2199@1|root,COG2206@1|root,COG2199@2|Bacteria,COG2206@2|Bacteria,1V6WM@1239|Firmicutes,25E5R@186801|Clostridia,2603J@186807|Peptococcaceae	186801|Clostridia	T	diguanylate cyclase (GGDEF) domain	-	-	-	-	-	-	-	-	-	-	-	-	5TM-5TMR_LYT,GGDEF,HD,HD_5,HisKA_7TM,PAS_9
REGS1_k127_2491701_3	1232410.KI421428_gene1050	5.903e-06	57.0	2E2XW@1|root,32XYS@2|Bacteria,1N3ID@1224|Proteobacteria,42UFM@68525|delta/epsilon subdivisions,2WQKF@28221|Deltaproteobacteria,43SQ0@69541|Desulfuromonadales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_2491701_2	398767.Glov_1585	1.223e-08	65.0	COG0457@1|root,COG0457@2|Bacteria	398767.Glov_1585|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_2491701_1	1123376.AUIU01000007_gene1185	1.827e-131	426.0	COG0152@1|root,COG0152@2|Bacteria,3J0U6@40117|Nitrospirae	40117|Nitrospirae	F	SAICAR synthetase	purC	GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
REGS1_k127_2491701_0	289376.THEYE_A1151	3.199e-147	472.0	COG0064@1|root,COG0064@2|Bacteria,3J0FK@40117|Nitrospirae	40117|Nitrospirae	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
REGS1_k127_249723_3	289376.THEYE_A1122	4.149e-57	204.0	COG0852@1|root,COG0852@2|Bacteria,3J168@40117|Nitrospirae	40117|Nitrospirae	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
REGS1_k127_249723_2	1123376.AUIU01000012_gene1386	4.661e-74	253.0	COG0377@1|root,COG0377@2|Bacteria,3J11S@40117|Nitrospirae	40117|Nitrospirae	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
REGS1_k127_249723_4	1232410.KI421424_gene1780	5.588e-39	148.0	COG0838@1|root,COG0838@2|Bacteria,1RGUT@1224|Proteobacteria,42UPV@68525|delta/epsilon subdivisions,2WQB6@28221|Deltaproteobacteria,43UXF@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3	nuoA	-	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
REGS1_k127_249723_1	243231.GSU0599	6.353e-103	353.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42P9E@68525|delta/epsilon subdivisions,2WMH3@28221|Deltaproteobacteria,43SU5@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	histidine kinase, HAMP	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4
REGS1_k127_249723_5	439235.Dalk_5071	2.83e-35	138.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42P5K@68525|delta/epsilon subdivisions,2WMEF@28221|Deltaproteobacteria,2MJFC@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
REGS1_k127_249723_0	338969.Rfer_2741	3.485e-124	407.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria	28216|Betaproteobacteria	T	response regulator	-	-	-	ko:K02481	-	-	-	-	ko00000,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
REGS1_k127_2503362_7	373903.Hore_13637	8.929e-44	167.0	COG0655@1|root,COG0655@2|Bacteria,1TRKM@1239|Firmicutes,24AD6@186801|Clostridia,3WAXS@53433|Halanaerobiales	186801|Clostridia	S	Flavodoxin-like fold	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red,Flavodoxin_2,SCP2
REGS1_k127_2503362_5	517418.Ctha_1584	5.449e-53	195.0	COG0431@1|root,COG0431@2|Bacteria	2|Bacteria	S	FMN reductase (NADPH) activity	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_2,FMN_bind,Flavodoxin_2,TIR_2
REGS1_k127_2503362_3	1120951.AUBG01000002_gene1238	7.789e-84	293.0	COG1680@1|root,COG1680@2|Bacteria,4P1Z2@976|Bacteroidetes	976|Bacteroidetes	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
REGS1_k127_2503362_0	706587.Desti_1303	0.0	1074.0	COG0506@1|root,COG1012@1|root,COG0506@2|Bacteria,COG1012@2|Bacteria,1MV93@1224|Proteobacteria,42MQH@68525|delta/epsilon subdivisions,2WJPV@28221|Deltaproteobacteria,2MR91@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Belongs to the aldehyde dehydrogenase family	putA	-	1.2.1.88,1.5.5.2	ko:K13821	ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130	-	R00245,R00707,R00708,R01253,R04444,R04445,R05051	RC00080,RC00083,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000,ko03000	-	-	iAF987.Gmet_3512	Aldedh,Pro_dh
REGS1_k127_2503362_4	289376.THEYE_A1276	2.363e-75	256.0	COG0440@1|root,COG0440@2|Bacteria,3J0K8@40117|Nitrospirae	40117|Nitrospirae	E	ACT domain	-	-	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,ACT_5,ALS_ss_C
REGS1_k127_2503362_1	289376.THEYE_A1275	5.827e-295	913.0	COG0028@1|root,COG0028@2|Bacteria,3J0D6@40117|Nitrospirae	40117|Nitrospirae	H	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
REGS1_k127_2503362_8	335543.Sfum_2816	7.754e-39	151.0	COG4314@1|root,COG4314@2|Bacteria,1N43A@1224|Proteobacteria,42U7U@68525|delta/epsilon subdivisions,2X378@28221|Deltaproteobacteria,2MS9C@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	NosL	-	-	-	-	-	-	-	-	-	-	-	-	NosL
REGS1_k127_2503362_9	765913.ThidrDRAFT_1392	5.313e-14	75.0	2E5GP@1|root,3308B@2|Bacteria,1N858@1224|Proteobacteria,1SV3I@1236|Gammaproteobacteria,1X1TC@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_2503362_6	765913.ThidrDRAFT_1391	8.729e-47	177.0	COG4591@1|root,COG4591@2|Bacteria,1QVSQ@1224|Proteobacteria,1SM1V@1236|Gammaproteobacteria,1X00A@135613|Chromatiales	135613|Chromatiales	M	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
REGS1_k127_2537284_0	247490.KSU1_C0675	0.0	1074.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1144@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1144@2|Bacteria,2IYDT@203682|Planctomycetes	203682|Planctomycetes	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	-	-	-	-	-	-	-	-	-	-	-	-	EKR,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C
REGS1_k127_2537284_1	338966.Ppro_3108	1.011e-152	495.0	COG2204@1|root,COG2204@2|Bacteria,1NR02@1224|Proteobacteria,42Y6M@68525|delta/epsilon subdivisions,2WU28@28221|Deltaproteobacteria,43TU1@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
REGS1_k127_2537284_2	1232410.KI421418_gene2197	1.254e-54	199.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,42M0W@68525|delta/epsilon subdivisions,2WIK8@28221|Deltaproteobacteria,43TXF@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS,PAS_9,Response_reg
REGS1_k127_2593887_1	1121459.AQXE01000002_gene1422	7.034e-42	162.0	COG0247@1|root,COG1139@1|root,COG0247@2|Bacteria,COG1139@2|Bacteria,1MV6J@1224|Proteobacteria,42MN2@68525|delta/epsilon subdivisions,2WIMJ@28221|Deltaproteobacteria,2M99N@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	LUD domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_7,Fer4_8,LUD_dom
REGS1_k127_2593887_0	289376.THEYE_A0167	1.242e-94	315.0	COG0176@1|root,COG0176@2|Bacteria,3J0YY@40117|Nitrospirae	40117|Nitrospirae	F	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	-	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
REGS1_k127_2593887_3	1123376.AUIU01000018_gene47	1.477e-20	92.0	COG2331@1|root,COG2331@2|Bacteria	2|Bacteria	P	Regulatory protein, FmdB family	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
REGS1_k127_2629318_2	742823.HMPREF9465_00585	1.551e-26	110.0	COG4942@1|root,COG4942@2|Bacteria,1MY3E@1224|Proteobacteria,2VIV9@28216|Betaproteobacteria,4PQVK@995019|Sutterellaceae	28216|Betaproteobacteria	D	Peptidase family M23	envC	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
REGS1_k127_2629318_0	289376.THEYE_A1481	3.15e-150	486.0	COG0793@1|root,COG0793@2|Bacteria,3J09Y@40117|Nitrospirae	40117|Nitrospirae	M	tail specific protease	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ,Peptidase_S41
REGS1_k127_2629318_1	945713.IALB_2257	1.347e-54	199.0	COG3298@1|root,COG3298@2|Bacteria	2|Bacteria	L	Predicted 3'-5' exonuclease related to the exonuclease domain of PolB	wlaX	-	-	ko:K07501	-	-	-	-	ko00000	-	-	-	DNA_pol_B_exo2
REGS1_k127_263499_4	639282.DEFDS_0601	1.005e-12	69.0	COG0206@1|root,COG0206@2|Bacteria,2GF5R@200930|Deferribacteres	200930|Deferribacteres	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
REGS1_k127_263499_0	316067.Geob_0785	3.178e-121	405.0	COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,42MS2@68525|delta/epsilon subdivisions,2WIQ0@28221|Deltaproteobacteria,43SXW@69541|Desulfuromonadales	28221|Deltaproteobacteria	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
REGS1_k127_263499_3	1123376.AUIU01000016_gene202	1.358e-32	136.0	COG1589@1|root,COG1589@2|Bacteria	2|Bacteria	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly	ftsQ	GO:0000003,GO:0000278,GO:0000281,GO:0000910,GO:0000917,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0019954,GO:0022402,GO:0022414,GO:0022607,GO:0031224,GO:0031226,GO:0032153,GO:0032505,GO:0032506,GO:0040007,GO:0042802,GO:0043093,GO:0044085,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0051301,GO:0061640,GO:0071840,GO:0071944,GO:0090529,GO:1902410,GO:1903047	6.3.2.4	ko:K01921,ko:K03589,ko:K06438	ko00473,ko00550,ko01100,ko01502,ko04112,map00473,map00550,map01100,map01502,map04112	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	FtsQ,POTRA_1
REGS1_k127_263499_1	289376.THEYE_A1319	3.475e-114	376.0	COG1181@1|root,COG1181@2|Bacteria,3J0JM@40117|Nitrospirae	40117|Nitrospirae	F	Cell wall formation	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
REGS1_k127_263499_2	580331.Thit_1648	3.737e-64	231.0	COG0812@1|root,COG0812@2|Bacteria,1TP3W@1239|Firmicutes,247IU@186801|Clostridia,42ETQ@68295|Thermoanaerobacterales	186801|Clostridia	M	Cell wall formation	murB	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
REGS1_k127_2697452_1	96561.Dole_0222	3.436e-156	499.0	COG0057@1|root,COG0057@2|Bacteria,1R8ZT@1224|Proteobacteria,42PY6@68525|delta/epsilon subdivisions,2WKEI@28221|Deltaproteobacteria,2MII4@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	-	-	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
REGS1_k127_2697452_0	1121405.dsmv_0564	0.0	1250.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MXBU@1224|Proteobacteria,42M59@68525|delta/epsilon subdivisions,2WIUK@28221|Deltaproteobacteria,2MICN@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Pyruvate phosphate dikinase, PEP	-	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
REGS1_k127_2711225_2	289376.THEYE_A0234	2.645e-52	190.0	COG1544@1|root,COG1544@2|Bacteria,3J0V7@40117|Nitrospirae	40117|Nitrospirae	J	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase	hpf	-	-	ko:K05808	-	-	-	-	ko00000,ko03009	-	-	-	Ribosom_S30AE_C,Ribosomal_S30AE
REGS1_k127_2711225_0	289376.THEYE_A0233	3.376e-162	524.0	COG1508@1|root,COG1508@2|Bacteria,3J0AT@40117|Nitrospirae	40117|Nitrospirae	K	Sigma-54 factor, Activator interacting domain (AID)	rpoN	-	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
REGS1_k127_2711225_1	243159.AFE_3026	1.517e-85	289.0	COG1137@1|root,COG1137@2|Bacteria,1MU8M@1224|Proteobacteria,1RPW1@1236|Gammaproteobacteria,2NCI1@225057|Acidithiobacillales	225057|Acidithiobacillales	P	ABC transporter	-	-	-	ko:K06861	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	1.B.42.1	-	-	ABC_tran
REGS1_k127_2711225_3	289376.THEYE_A0231	5.328e-36	139.0	COG1934@1|root,COG1934@2|Bacteria,3J1EG@40117|Nitrospirae	40117|Nitrospirae	S	OstA-like protein	-	-	-	ko:K09774	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA
REGS1_k127_2719993_4	1232410.KI421413_gene814	1.342e-42	161.0	COG3267@1|root,COG3267@2|Bacteria,1REY9@1224|Proteobacteria,42RJB@68525|delta/epsilon subdivisions,2WN99@28221|Deltaproteobacteria,43TEB@69541|Desulfuromonadales	28221|Deltaproteobacteria	U	Pfam:Arch_ATPase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22
REGS1_k127_2719993_6	1121434.AULY01000006_gene482	3.1e-22	106.0	COG0835@1|root,COG0835@2|Bacteria,1RD1W@1224|Proteobacteria,42T5Y@68525|delta/epsilon subdivisions,2WNT6@28221|Deltaproteobacteria,2MAZR@213115|Desulfovibrionales	28221|Deltaproteobacteria	NT	PFAM CheW domain protein	-	-	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
REGS1_k127_2719993_0	483219.LILAB_16735	1.178e-83	310.0	COG0840@1|root,COG3850@1|root,COG0840@2|Bacteria,COG3850@2|Bacteria,1RG2B@1224|Proteobacteria,42RYX@68525|delta/epsilon subdivisions,2WNHC@28221|Deltaproteobacteria,2YU4H@29|Myxococcales	28221|Deltaproteobacteria	NT	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer).	rppA	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal
REGS1_k127_2719993_3	398767.Glov_1153	1.504e-43	183.0	COG3221@1|root,COG3221@2|Bacteria,1MXD8@1224|Proteobacteria,42VZ4@68525|delta/epsilon subdivisions,2WRDI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	ABC transporter, phosphonate, periplasmic substrate-binding protein	phnD	-	-	ko:K02044	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	Phosphonate-bd
REGS1_k127_2719993_2	296591.Bpro_1647	7.427e-45	173.0	COG0226@1|root,COG0226@2|Bacteria,1MVXP@1224|Proteobacteria,2WG0X@28216|Betaproteobacteria	28216|Betaproteobacteria	P	PBP superfamily domain	-	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
REGS1_k127_2719993_1	290397.Adeh_0058	8.086e-76	280.0	COG0840@1|root,COG3850@1|root,COG0840@2|Bacteria,COG3850@2|Bacteria,1RG2B@1224|Proteobacteria,42RYX@68525|delta/epsilon subdivisions,2WNHC@28221|Deltaproteobacteria,2YU4H@29|Myxococcales	28221|Deltaproteobacteria	NT	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer).	rppA	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal
REGS1_k127_2719993_5	1121413.JMKT01000014_gene2634	9.91e-28	118.0	COG0835@1|root,COG0835@2|Bacteria,1RAH1@1224|Proteobacteria,42S69@68525|delta/epsilon subdivisions,2X5TT@28221|Deltaproteobacteria,2MGVV@213115|Desulfovibrionales	28221|Deltaproteobacteria	NT	Two component signalling adaptor domain	cheW	-	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
REGS1_k127_2732512_0	555779.Dthio_PD1689	5.365e-42	160.0	COG1848@1|root,COG1848@2|Bacteria,1N5KS@1224|Proteobacteria,42UG5@68525|delta/epsilon subdivisions,2WQVY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	PIN
REGS1_k127_2732512_2	589865.DaAHT2_2647	1.343e-18	87.0	COG2002@1|root,COG2002@2|Bacteria,1NH3J@1224|Proteobacteria,42X1Z@68525|delta/epsilon subdivisions,2WT86@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	TIGRFAM transcriptional regulator, AbrB family	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin
REGS1_k127_2732512_1	555779.Dthio_PD0015	1.211e-29	122.0	COG1569@1|root,COG1569@2|Bacteria,1Q9X7@1224|Proteobacteria,42X9V@68525|delta/epsilon subdivisions,2WT2V@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN_3
REGS1_k127_2732512_3	1123354.AUDR01000012_gene1753	2.533e-18	86.0	COG2336@1|root,COG2336@2|Bacteria,1NBUD@1224|Proteobacteria,2VWF5@28216|Betaproteobacteria	28216|Betaproteobacteria	T	PFAM SpoVT AbrB	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_2746289_1	929556.Solca_3263	3.751e-169	541.0	COG3328@1|root,COG3328@2|Bacteria,4NFQS@976|Bacteroidetes,1IPP3@117747|Sphingobacteriia	976|Bacteroidetes	L	COG3328 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
REGS1_k127_2746289_2	1167006.UWK_02010	8.838e-159	514.0	COG1032@1|root,COG1032@2|Bacteria,1MWR0@1224|Proteobacteria	1224|Proteobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
REGS1_k127_2746289_3	909663.KI867150_gene1012	9.528e-138	447.0	COG0577@1|root,COG0577@2|Bacteria,1MWBK@1224|Proteobacteria,42PZC@68525|delta/epsilon subdivisions,2WK59@28221|Deltaproteobacteria,2MQUU@213462|Syntrophobacterales	28221|Deltaproteobacteria	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
REGS1_k127_2746289_0	289376.THEYE_A0114	8.951e-206	642.0	COG0473@1|root,COG0473@2|Bacteria,3J0JQ@40117|Nitrospirae	40117|Nitrospirae	C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
REGS1_k127_2746289_4	909663.KI867150_gene410	1.433e-49	183.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MFW@68525|delta/epsilon subdivisions,2WKMP@28221|Deltaproteobacteria,2MQVW@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_9,Response_reg
REGS1_k127_2752288_2	696281.Desru_0234	1.225e-05	51.0	COG0801@1|root,COG0801@2|Bacteria,1V6PR@1239|Firmicutes,249YP@186801|Clostridia,2629P@186807|Peptococcaceae	186801|Clostridia	H	PFAM 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK	folK	-	2.7.6.3,4.1.2.25	ko:K00950,ko:K13940	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503,R03504	RC00002,RC00017,RC00721,RC00943	ko00000,ko00001,ko00002,ko01000	-	-	-	FolB,HPPK
REGS1_k127_2752288_0	289376.THEYE_A0137	5.987e-179	567.0	COG0436@1|root,COG0436@2|Bacteria,3J0G2@40117|Nitrospirae	40117|Nitrospirae	E	Aminotransferase class I and II	-	-	2.6.1.83	ko:K10206	ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230	M00527	R07613	RC00006,RC01847	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
REGS1_k127_2752288_1	1242864.D187_010394	5.933e-17	92.0	COG2905@1|root,COG2905@2|Bacteria,1R0B9@1224|Proteobacteria,43CTI@68525|delta/epsilon subdivisions,2X8MP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	ko:K04739	ko04910,map04910	-	-	-	ko00000,ko00001	-	-	-	cNMP_binding
REGS1_k127_2752950_3	1123376.AUIU01000011_gene970	1.067e-23	107.0	COG0247@1|root,COG0247@2|Bacteria	2|Bacteria	C	lactate metabolic process	-	-	-	ko:K11473,ko:K18928	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	CCG,Fer4_8
REGS1_k127_2752950_2	580327.Tthe_1034	2.907e-83	284.0	COG1606@1|root,COG1606@2|Bacteria,1TPB2@1239|Firmicutes,2485J@186801|Clostridia,42FCT@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM PP-loop domain protein	-	-	-	ko:K06864	-	-	-	-	ko00000	-	-	-	ATP_bind_3,NAD_synthase
REGS1_k127_2752950_0	316067.Geob_1241	1.359e-186	596.0	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,42M5E@68525|delta/epsilon subdivisions,2WIV6@28221|Deltaproteobacteria,43TM0@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	TIGRFAM ribonuclease, Rne Rng family	cafA	-	3.1.26.12	ko:K08300,ko:K08301	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
REGS1_k127_2752950_1	1123376.AUIU01000011_gene968	2.154e-87	304.0	COG1032@1|root,COG5011@1|root,COG1032@2|Bacteria,COG5011@2|Bacteria	2|Bacteria	C	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF2344,Radical_SAM
REGS1_k127_278197_3	1379698.RBG1_1C00001G0657	7.534e-61	211.0	COG2259@1|root,COG2259@2|Bacteria	2|Bacteria	S	methylamine metabolic process	Z012_09115	-	-	ko:K15977	-	-	-	-	ko00000	-	-	-	DoxX
REGS1_k127_278197_0	477974.Daud_0348	1.696e-177	572.0	COG0517@1|root,COG1227@1|root,COG0517@2|Bacteria,COG1227@2|Bacteria,1TPH6@1239|Firmicutes,248RQ@186801|Clostridia,260EW@186807|Peptococcaceae	186801|Clostridia	C	DHHA2 domain	ppaC	-	3.6.1.1	ko:K15986	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	CBS,DHH,DHHA2,DRTGG
REGS1_k127_278197_4	351627.Csac_2301	1.02e-25	108.0	2E32K@1|root,32Y2U@2|Bacteria,1VFFP@1239|Firmicutes,24RID@186801|Clostridia,42IMC@68295|Thermoanaerobacterales	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_278197_2	289376.THEYE_A1223	1.717e-148	489.0	COG0486@1|root,COG0486@2|Bacteria,3J0JZ@40117|Nitrospirae	40117|Nitrospirae	S	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34	trmE	-	-	ko:K03650	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko01000,ko03016	-	-	-	MMR_HSR1,MnmE_helical,TrmE_N
REGS1_k127_278197_1	289376.THEYE_A1224	5.412e-153	499.0	COG0706@1|root,COG0706@2|Bacteria,3J0GD@40117|Nitrospirae	40117|Nitrospirae	U	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins	yidC	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP,YidC_periplas
REGS1_k127_278197_5	580332.Slit_2995	3.866e-24	102.0	COG0759@1|root,COG0759@2|Bacteria,1N6U4@1224|Proteobacteria,2VVTR@28216|Betaproteobacteria,44W1S@713636|Nitrosomonadales	28216|Betaproteobacteria	S	Could be involved in insertion of integral membrane proteins into the membrane	yidD	-	-	ko:K08998	-	-	-	-	ko00000	-	-	-	Haemolytic
REGS1_k127_278197_7	1160721.RBI_I02074	7.597e-14	76.0	COG0594@1|root,COG0594@2|Bacteria,1VA78@1239|Firmicutes,24QK5@186801|Clostridia,3WKGV@541000|Ruminococcaceae	186801|Clostridia	J	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme	rnpA	-	3.1.26.5	ko:K03536	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_P
REGS1_k127_278197_6	1123376.AUIU01000014_gene718	8.147e-17	81.0	COG0230@1|root,COG0230@2|Bacteria	2|Bacteria	J	Ribosomal protein L34	rpmH	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02914	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L34
REGS1_k127_278197_8	1047013.AQSP01000109_gene2440	8.55e-13	72.0	COG2002@1|root,COG2002@2|Bacteria	2|Bacteria	K	toxin-antitoxin pair type II binding	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin
REGS1_k127_2841131_0	429009.Adeg_0336	1.088e-141	461.0	COG1614@1|root,COG1614@2|Bacteria,1TSWZ@1239|Firmicutes,248Y2@186801|Clostridia,42EW2@68295|Thermoanaerobacterales	186801|Clostridia	C	CO dehydrogenase acetyl-CoA synthase complex beta subunit	cdhC	-	2.3.1.169	ko:K14138	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00377	R08433,R10243	RC00004,RC00113,RC01144,RC02963,RC02964,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhC
REGS1_k127_2865164_2	289376.THEYE_A1846	2.111e-134	437.0	COG0772@1|root,COG0772@2|Bacteria,3J0IA@40117|Nitrospirae	40117|Nitrospirae	D	Peptidoglycan polymerase that is essential for cell wall elongation	mrdB	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
REGS1_k127_2865164_1	243231.GSU2079	1.18e-153	504.0	COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,42M1S@68525|delta/epsilon subdivisions,2WJ02@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Penicillin-binding protein 2	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	iAF987.Gmet_0928	PBP_dimer,Transpeptidase
REGS1_k127_2865164_3	1123376.AUIU01000013_gene1885	4.462e-44	171.0	COG1792@1|root,COG1792@2|Bacteria,3J0S3@40117|Nitrospirae	40117|Nitrospirae	M	shape-determining protein MreC	mreC	-	-	ko:K03570	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreC
REGS1_k127_2865164_0	289376.THEYE_A1842	8.164e-162	514.0	COG1077@1|root,COG1077@2|Bacteria,3J0BS@40117|Nitrospirae	40117|Nitrospirae	D	Actin	-	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
REGS1_k127_2875359_0	243231.GSU0094	6.393e-117	389.0	COG2812@1|root,COG2812@2|Bacteria,1MVCK@1224|Proteobacteria,42M09@68525|delta/epsilon subdivisions,2WJ1G@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
REGS1_k127_2875359_5	880073.Calab_0869	1.315e-12	69.0	COG1180@1|root,COG1180@2|Bacteria,2NNMV@2323|unclassified Bacteria	2|Bacteria	O	Elongator protein 3, MiaB family, Radical SAM	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
REGS1_k127_2875359_1	880073.Calab_0988	2.574e-99	341.0	COG1355@1|root,COG2078@1|root,COG1355@2|Bacteria,COG2078@2|Bacteria,2NPAA@2323|unclassified Bacteria	2|Bacteria	S	AMMECR1	-	-	-	ko:K06990,ko:K09141	-	-	-	-	ko00000,ko04812	-	-	-	AMMECR1,Memo
REGS1_k127_2875359_7	380749.HY04AAS1_0394	0.000159	53.0	COG2201@1|root,COG2201@2|Bacteria,2G4FK@200783|Aquificae	200783|Aquificae	NT	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	cheB	-	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,Response_reg
REGS1_k127_2875359_6	633697.EubceDRAFT1_1084	1.858e-12	78.0	COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,247VG@186801|Clostridia,25UZG@186806|Eubacteriaceae	186801|Clostridia	T	ATPase histidine kinase DNA gyrase B HSP90 domain protein	-	-	2.7.13.3	ko:K02484	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
REGS1_k127_2875359_3	1123288.SOV_1c09750	9.486e-36	151.0	COG0079@1|root,COG0079@2|Bacteria,1TP5D@1239|Firmicutes,4H2R0@909932|Negativicutes	909932|Negativicutes	E	Aminotransferase	-	-	4.1.1.81	ko:K04720	ko00860,map00860	-	R06530	RC00517	ko00000,ko00001,ko01000	-	-	-	Aminotran_1_2
REGS1_k127_2875359_2	1304883.KI912532_gene1266	1.755e-66	241.0	COG2607@1|root,COG2607@2|Bacteria,1MVMX@1224|Proteobacteria,2VID5@28216|Betaproteobacteria,2KUQI@206389|Rhodocyclales	206389|Rhodocyclales	S	ATPase (AAA	-	-	-	ko:K06923	-	-	-	-	ko00000	-	-	-	DUF815
REGS1_k127_2875359_4	690850.Desaf_2565	1.147e-29	121.0	2BIF3@1|root,32CMK@2|Bacteria,1PZIU@1224|Proteobacteria,43602@68525|delta/epsilon subdivisions,2X0HK@28221|Deltaproteobacteria,2MCCC@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
REGS1_k127_2878920_2	96561.Dole_1491	1.872e-05	47.0	COG0500@1|root,COG2226@2|Bacteria,1MX8I@1224|Proteobacteria,42P2Z@68525|delta/epsilon subdivisions,2WNJ6@28221|Deltaproteobacteria,2MJ9N@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)	ubiE	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
REGS1_k127_2878920_0	1122176.KB903544_gene756	2.647e-80	288.0	COG0661@1|root,COG0661@2|Bacteria,4NDUP@976|Bacteroidetes,1IRIK@117747|Sphingobacteriia	976|Bacteroidetes	S	ABC1 family	-	-	-	-	-	-	-	-	-	-	-	-	ABC1,APH
REGS1_k127_2878920_3	926569.ANT_28370	9.384e-05	47.0	COG1651@1|root,COG1651@2|Bacteria,2G769@200795|Chloroflexi	200795|Chloroflexi	O	PFAM DSBA oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_4
REGS1_k127_2878920_1	289376.THEYE_A1305	4.35e-48	175.0	COG1651@1|root,COG1651@2|Bacteria,3J19Z@40117|Nitrospirae	40117|Nitrospirae	O	DSBA-like thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_2883188_4	933262.AXAM01000041_gene1914	5.608e-90	301.0	COG2360@1|root,COG2360@2|Bacteria,1R9W8@1224|Proteobacteria,42QRC@68525|delta/epsilon subdivisions,2WMP7@28221|Deltaproteobacteria,2MHMA@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine	aat	-	2.3.2.6	ko:K00684	-	-	R03813,R11443,R11444	RC00055,RC00064	ko00000,ko01000	-	-	-	Leu_Phe_trans
REGS1_k127_2883188_0	1307759.JOMJ01000003_gene779	5.045e-277	870.0	COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,42M2T@68525|delta/epsilon subdivisions,2WJ2W@28221|Deltaproteobacteria,2M92I@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	ATP-dependent Clp protease ATP-binding subunit ClpA	clpA	-	-	ko:K03694	-	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
REGS1_k127_2883188_7	228405.HNE_1029	7.303e-31	124.0	COG2127@1|root,COG2127@2|Bacteria,1MZU8@1224|Proteobacteria,2U982@28211|Alphaproteobacteria,43XVS@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation	clpS	-	-	ko:K06891	-	-	-	-	ko00000	-	-	-	ClpS
REGS1_k127_2883188_6	1121439.dsat_0683	4.165e-40	158.0	COG0534@1|root,COG0534@2|Bacteria,1NS6X@1224|Proteobacteria,42MWN@68525|delta/epsilon subdivisions,2WMPY@28221|Deltaproteobacteria,2M9QH@213115|Desulfovibrionales	28221|Deltaproteobacteria	V	PFAM Multi antimicrobial extrusion protein MatE	-	-	-	ko:K03327	-	-	-	-	ko00000,ko02000	2.A.66.1	-	-	MatE
REGS1_k127_2883188_5	335543.Sfum_2333	1.86e-65	231.0	COG0534@1|root,COG0534@2|Bacteria,1NS6X@1224|Proteobacteria,42MWN@68525|delta/epsilon subdivisions,2WMPY@28221|Deltaproteobacteria,2MQVZ@213462|Syntrophobacterales	28221|Deltaproteobacteria	V	MatE	-	-	-	ko:K03327	-	-	-	-	ko00000,ko02000	2.A.66.1	-	-	MatE
REGS1_k127_2883188_3	335543.Sfum_4051	3.148e-119	395.0	COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,42M04@68525|delta/epsilon subdivisions,2WJJD@28221|Deltaproteobacteria	68525|delta/epsilon subdivisions	J	Belongs to the class-I aminoacyl-tRNA synthetase family	-	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1e
REGS1_k127_2883188_1	56780.SYN_00538	3.79e-191	611.0	COG1032@1|root,COG1032@2|Bacteria,1PDZR@1224|Proteobacteria,42M73@68525|delta/epsilon subdivisions,2WK6Y@28221|Deltaproteobacteria,2MQ41@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
REGS1_k127_2883188_2	1167006.UWK_02855	3.225e-186	610.0	COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42N46@68525|delta/epsilon subdivisions,2WJT4@28221|Deltaproteobacteria,2MPMZ@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,PocR,Response_reg
REGS1_k127_2919258_4	237368.SCABRO_00899	4.578e-24	102.0	COG1724@1|root,COG1724@2|Bacteria	2|Bacteria	N	mRNA binding	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
REGS1_k127_2919258_3	237368.SCABRO_00900	3.757e-26	109.0	COG1598@1|root,COG1598@2|Bacteria	2|Bacteria	N	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_2919258_1	431943.CKL_2916	1.181e-148	477.0	COG0722@1|root,COG0722@2|Bacteria,1TQI4@1239|Firmicutes,24842@186801|Clostridia,36DMI@31979|Clostridiaceae	186801|Clostridia	E	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)	aroH	-	2.5.1.54	ko:K01626	ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS07240	DAHP_synth_1
REGS1_k127_2919258_5	653733.Selin_0993	2.083e-05	47.0	COG3169@1|root,COG3169@2|Bacteria	2|Bacteria	S	Protein conserved in bacteria	-	-	-	ko:K09922	-	-	-	-	ko00000	-	-	-	DMT_6
REGS1_k127_2919258_6	857087.Metme_3355	2.472e-05	53.0	2AEIT@1|root,314E9@2|Bacteria,1QIXM@1224|Proteobacteria,1TGU1@1236|Gammaproteobacteria,1XGP6@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_2919258_0	1121403.AUCV01000001_gene873	7.685e-216	677.0	COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,42MSQ@68525|delta/epsilon subdivisions,2WISJ@28221|Deltaproteobacteria,2MPW4@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	paaK-1	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
REGS1_k127_2919258_2	589865.DaAHT2_0101	1.132e-72	248.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,42M5A@68525|delta/epsilon subdivisions,2WK03@28221|Deltaproteobacteria,2MJNZ@213118|Desulfobacterales	28221|Deltaproteobacteria	E	ABC transporter	livF	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
REGS1_k127_29453_1	1131269.AQVV01000011_gene2508	1.684e-140	461.0	COG0836@1|root,COG0836@2|Bacteria	2|Bacteria	M	mannose-1-phosphate guanylyltransferase activity	manC	-	2.7.7.13,5.3.1.8,5.4.2.8	ko:K00971,ko:K01840,ko:K16011	ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025	M00114,M00361,M00362	R00885,R01818,R01819	RC00002,RC00376,RC00408	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS00940	MannoseP_isomer,NTP_transferase
REGS1_k127_29453_0	667014.Thein_2165	1.537e-158	512.0	COG1109@1|root,COG1109@2|Bacteria,2GHQ7@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	G	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III	-	-	5.4.2.2,5.4.2.8	ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
REGS1_k127_29453_2	289376.THEYE_A0468	1.238e-132	430.0	COG1087@1|root,COG1087@2|Bacteria,3J0J5@40117|Nitrospirae	40117|Nitrospirae	M	Polysaccharide biosynthesis protein	galE	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
REGS1_k127_3018792_2	909663.KI867150_gene278	2.667e-41	153.0	COG0821@1|root,COG0821@2|Bacteria,1MUAX@1224|Proteobacteria,42M3V@68525|delta/epsilon subdivisions,2WJJ4@28221|Deltaproteobacteria,2MQ70@213462|Syntrophobacterales	28221|Deltaproteobacteria	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046429,GO:0046490,GO:0052592,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
REGS1_k127_3018792_1	909663.KI867150_gene280	1.719e-49	183.0	COG0558@1|root,COG0558@2|Bacteria,1N9TT@1224|Proteobacteria,42V2Q@68525|delta/epsilon subdivisions,2WRYY@28221|Deltaproteobacteria,2MSEQ@213462|Syntrophobacterales	28221|Deltaproteobacteria	I	CDP-alcohol phosphatidyltransferase	-	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf,GtrA
REGS1_k127_3018792_0	909663.KI867150_gene281	1.479e-163	518.0	COG1260@1|root,COG1260@2|Bacteria,1N0D9@1224|Proteobacteria,42NWK@68525|delta/epsilon subdivisions,2WM2T@28221|Deltaproteobacteria,2MQPV@213462|Syntrophobacterales	28221|Deltaproteobacteria	I	Myo-inositol-1-phosphate synthase	-	-	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth,NAD_binding_5
REGS1_k127_3021877_2	177439.DP2415	1.513e-153	494.0	COG0006@1|root,COG0006@2|Bacteria,1N763@1224|Proteobacteria,42PVQ@68525|delta/epsilon subdivisions,2WK4N@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	PFAM peptidase M24	-	-	3.4.11.9,3.4.13.9	ko:K01262,ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
REGS1_k127_3021877_3	289376.THEYE_A0549	4.836e-89	301.0	COG1187@1|root,COG1187@2|Bacteria,3J0RN@40117|Nitrospirae	40117|Nitrospirae	J	Belongs to the pseudouridine synthase RsuA family	-	-	5.4.99.22	ko:K06178	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
REGS1_k127_3021877_0	289376.THEYE_A0617	1.919e-258	809.0	COG0173@1|root,COG0173@2|Bacteria,3J0FR@40117|Nitrospirae	40117|Nitrospirae	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
REGS1_k127_3021877_1	706587.Desti_2042	5.687e-160	519.0	COG0364@1|root,COG0364@2|Bacteria,1MUN0@1224|Proteobacteria,42M0J@68525|delta/epsilon subdivisions,2WK1D@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	zwf	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
REGS1_k127_3021877_4	179408.Osc7112_0763	8.049e-53	194.0	COG1215@1|root,COG1215@2|Bacteria,1GDJY@1117|Cyanobacteria,1H8JX@1150|Oscillatoriales	1117|Cyanobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
REGS1_k127_3021877_5	945713.IALB_1975	2.944e-39	154.0	COG1215@1|root,COG3222@1|root,COG1215@2|Bacteria,COG3222@2|Bacteria	2|Bacteria	S	Uncharacterized protein conserved in bacteria (DUF2064)	-	-	3.4.14.13	ko:K09931,ko:K20742	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DUF2064,Glycos_transf_2
REGS1_k127_3021877_6	1123376.AUIU01000014_gene579	1.696e-25	107.0	COG0564@1|root,COG0564@2|Bacteria,3J0HF@40117|Nitrospirae	40117|Nitrospirae	J	Responsible for synthesis of pseudouridine from uracil	-	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
REGS1_k127_3042444_2	411902.CLOBOL_01826	1.553e-53	196.0	COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,247PV@186801|Clostridia,21YUI@1506553|Lachnoclostridium	186801|Clostridia	IQ	COG COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	fabG	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
REGS1_k127_3042444_1	289376.THEYE_A1875	1.834e-63	225.0	COG0132@1|root,COG0132@2|Bacteria,3J0SI@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring	bioD	GO:0003674,GO:0003824,GO:0004141,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.3.3	ko:K01935	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03182	RC00868	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_26
REGS1_k127_3042444_0	289376.THEYE_A0933	4.779e-141	453.0	COG0329@1|root,COG0329@2|Bacteria,3J0CF@40117|Nitrospirae	40117|Nitrospirae	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
REGS1_k127_3045403_1	289376.THEYE_A0321	9.913e-52	189.0	COG1625@1|root,COG1625@2|Bacteria,3J0XK@40117|Nitrospirae	40117|Nitrospirae	C	Protein of unknown function (DUF512)	-	-	-	-	-	-	-	-	-	-	-	-	DUF512
REGS1_k127_3045403_0	1123376.AUIU01000011_gene893	3.894e-80	278.0	COG0169@1|root,COG0169@2|Bacteria,3J0SM@40117|Nitrospirae	40117|Nitrospirae	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	GO:0000166,GO:0003674,GO:0003824,GO:0004764,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576,GO:1901615	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_DH,Shikimate_dh_N
REGS1_k127_3045403_2	585503.HMPREF7545_0854	5.575e-05	51.0	COG3117@1|root,COG3117@2|Bacteria,1V9U6@1239|Firmicutes,4H4TV@909932|Negativicutes	909932|Negativicutes	S	Lipopolysaccharide-assembly, LptC-related	-	-	-	-	-	-	-	-	-	-	-	-	LptC
REGS1_k127_3051620_2	933262.AXAM01000009_gene1484	1.248e-41	160.0	COG0727@1|root,COG0727@2|Bacteria,1RG3R@1224|Proteobacteria,42RR7@68525|delta/epsilon subdivisions,2WP18@28221|Deltaproteobacteria,2MKRX@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM Uncharacterised protein family (UPF0153)	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_3051620_1	933262.AXAM01000127_gene1027	1.893e-48	182.0	COG0138@1|root,COG0138@2|Bacteria,1N2UC@1224|Proteobacteria,42NFS@68525|delta/epsilon subdivisions,2X5JJ@28221|Deltaproteobacteria,2MIV7@213118|Desulfobacterales	28221|Deltaproteobacteria	F	MGS-like domain	-	-	-	-	-	-	-	-	-	-	-	-	AICARFT_IMPCHas,MGS
REGS1_k127_3051620_0	1125863.JAFN01000001_gene869	6.096e-65	231.0	COG1651@1|root,COG1651@2|Bacteria,1RD39@1224|Proteobacteria,42QRZ@68525|delta/epsilon subdivisions,2WMZS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process	-	-	5.3.4.1	ko:K03981	-	-	-	-	ko00000,ko01000,ko02044,ko03110	3.A.7.11.1	-	-	DsbC_N,Thioredoxin_2
REGS1_k127_306488_1	338966.Ppro_1272	1.488e-34	134.0	COG1943@1|root,COG1943@2|Bacteria,1RIWM@1224|Proteobacteria,42SBY@68525|delta/epsilon subdivisions,2WPSK@28221|Deltaproteobacteria,43V9B@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	Transposase IS200 like	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_306488_0	56780.SYN_00561	1.082e-146	477.0	COG0389@1|root,COG0389@2|Bacteria,1MUUH@1224|Proteobacteria,42NGG@68525|delta/epsilon subdivisions,2WIVT@28221|Deltaproteobacteria,2MQEQ@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
REGS1_k127_3066386_2	877455.Metbo_1710	7.056e-27	120.0	arCOG10445@1|root,arCOG10445@2157|Archaea,2Y3V6@28890|Euryarchaeota	28890|Euryarchaeota	S	Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase	-	-	-	-	-	-	-	-	-	-	-	-	AAT
REGS1_k127_3066386_0	289376.THEYE_A1047	1.325e-244	767.0	COG0442@1|root,COG0442@2|Bacteria,3J0EY@40117|Nitrospirae	40117|Nitrospirae	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
REGS1_k127_3066386_1	1123376.AUIU01000011_gene908	9.801e-44	161.0	COG0782@1|root,COG0782@2|Bacteria,3J0NA@40117|Nitrospirae	40117|Nitrospirae	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	-	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
REGS1_k127_3078216_1	43989.cce_4924	8.038e-08	57.0	COG0864@1|root,COG0864@2|Bacteria,1G9E4@1117|Cyanobacteria	1117|Cyanobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_3078216_0	1232410.KI421422_gene1998	9.106e-160	514.0	COG0535@1|root,COG0535@2|Bacteria,1NJ3W@1224|Proteobacteria,42PQJ@68525|delta/epsilon subdivisions,2WKAV@28221|Deltaproteobacteria,43T18@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_14,Radical_SAM,SPASM
REGS1_k127_309208_3	269799.Gmet_3376	5.588e-67	234.0	2A8Q5@1|root,30XSS@2|Bacteria,1RGZW@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_309208_4	289376.THEYE_A0327	9.946e-65	226.0	COG1852@1|root,COG1852@2|Bacteria	2|Bacteria	S	Protein of unknown function DUF116	-	-	-	ko:K09729	-	-	-	-	ko00000	-	-	-	DUF116,polyprenyl_synt
REGS1_k127_309208_0	289376.THEYE_A0328	7.031e-101	337.0	COG0223@1|root,COG0223@2|Bacteria,3J0GW@40117|Nitrospirae	40117|Nitrospirae	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
REGS1_k127_309208_5	1123376.AUIU01000011_gene1055	1.013e-57	205.0	COG0242@1|root,COG0242@2|Bacteria,3J0RI@40117|Nitrospirae	40117|Nitrospirae	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	-	GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0018193,GO:0018206,GO:0019538,GO:0031365,GO:0036211,GO:0042586,GO:0043170,GO:0043412,GO:0043686,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
REGS1_k127_309208_9	880072.Desac_2312	1.212e-08	66.0	COG1040@1|root,COG1040@2|Bacteria	2|Bacteria	K	competence protein	-	-	-	-	-	-	-	-	-	-	-	-	Band_7_1,DZR,Pribosyltran,Proteasom_PSMB,zinc_ribbon_2
REGS1_k127_309208_1	667014.Thein_0040	1.369e-94	325.0	COG0144@1|root,COG0781@1|root,COG0144@2|Bacteria,COG0781@2|Bacteria,2GGSR@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	J	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA	-	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,NusB
REGS1_k127_309208_10	1405498.SSIM_08195	0.0002978	51.0	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,1TP3F@1239|Firmicutes,4H9KD@91061|Bacilli,4GY5R@90964|Staphylococcaceae	91061|Bacilli	KLT	Serine threonine protein kinase	prkC	GO:0002237,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005539,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009617,GO:0009719,GO:0009847,GO:0009987,GO:0010033,GO:0010243,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0023052,GO:0032494,GO:0032502,GO:0036211,GO:0042221,GO:0042834,GO:0043170,GO:0043207,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051704,GO:0051707,GO:0051716,GO:0065007,GO:0070887,GO:0071216,GO:0071219,GO:0071224,GO:0071310,GO:0071417,GO:0071495,GO:0071704,GO:0071944,GO:0097367,GO:0140096,GO:1901564,GO:1901698,GO:1901699,GO:1901700,GO:1901701	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
REGS1_k127_309208_2	1499680.CCFE01000024_gene2793	1.811e-83	282.0	COG0036@1|root,COG0036@2|Bacteria,1TQK8@1239|Firmicutes,4H9RW@91061|Bacilli,1ZCUF@1386|Bacillus	91061|Bacilli	G	Belongs to the ribulose-phosphate 3-epimerase family	rpe	GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046496,GO:0046872,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
REGS1_k127_309208_6	1123376.AUIU01000011_gene1061	2.29e-57	213.0	COG0457@1|root,COG0457@2|Bacteria	1123376.AUIU01000011_gene1061|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_309208_8	1232410.KI421414_gene2904	1.006e-31	130.0	COG0558@1|root,COG0558@2|Bacteria,1MZ8B@1224|Proteobacteria,42TIF@68525|delta/epsilon subdivisions,2WQC4@28221|Deltaproteobacteria,43SR3@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	CDP-alcohol phosphatidyltransferase	pgsA-2	-	2.7.8.41	ko:K08744	ko00564,ko01100,map00564,map01100	-	R02030	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
REGS1_k127_309208_7	289376.THEYE_A0321	8.425e-54	194.0	COG1625@1|root,COG1625@2|Bacteria,3J0XK@40117|Nitrospirae	40117|Nitrospirae	C	Protein of unknown function (DUF512)	-	-	-	-	-	-	-	-	-	-	-	-	DUF512
REGS1_k127_3106746_1	1123376.AUIU01000011_gene1067	8.794e-54	194.0	COG0620@1|root,COG0620@2|Bacteria	2|Bacteria	E	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation	-	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
REGS1_k127_3106746_2	378806.STAUR_5941	2.28e-05	55.0	COG2027@1|root,COG2027@2|Bacteria,1RKPD@1224|Proteobacteria,42S90@68525|delta/epsilon subdivisions,2WNM2@28221|Deltaproteobacteria,2YWWU@29|Myxococcales	28221|Deltaproteobacteria	M	Protein of unknown function (DUF1460)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1460
REGS1_k127_3106746_0	1123376.AUIU01000011_gene1065	3.668e-139	451.0	COG1924@1|root,COG3580@1|root,COG3581@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,COG3581@2|Bacteria,3J0XX@40117|Nitrospirae	40117|Nitrospirae	I	CoA enzyme activase uncharacterised domain (DUF2229)	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,DUF2229
REGS1_k127_3153988_4	398767.Glov_1270	3.478e-53	199.0	2A20V@1|root,30QAU@2|Bacteria,1RDQH@1224|Proteobacteria,4330X@68525|delta/epsilon subdivisions,2WXN7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_3153988_3	269799.Gmet_0248	1.411e-53	198.0	COG1999@1|root,COG1999@2|Bacteria,1R9EM@1224|Proteobacteria,42N5F@68525|delta/epsilon subdivisions,2WKG7@28221|Deltaproteobacteria,43RX9@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	protein SCO1 SenC PrrC involved in biogenesis of respiratory and photosynthetic systems	sco	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	-
REGS1_k127_3153988_0	1191523.MROS_0038	5.884e-238	745.0	COG0843@1|root,COG0843@2|Bacteria	2|Bacteria	C	heme-copper terminal oxidase activity	ctaD	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
REGS1_k127_3153988_2	945713.IALB_1395	1.114e-70	244.0	COG1845@1|root,COG1845@2|Bacteria	2|Bacteria	C	cytochrome c oxidase, subunit III	coxC	-	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
REGS1_k127_3153988_1	269799.Gmet_0252	2.896e-91	309.0	COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,1MWHZ@1224|Proteobacteria,42M7N@68525|delta/epsilon subdivisions,2WM4F@28221|Deltaproteobacteria,43T32@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	coxB	-	1.10.3.10,1.9.3.1	ko:K02275,ko:K02297	ko00190,ko01100,map00190,map01100	M00155,M00417	R00081,R11335	RC00016,RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.5,3.D.4.6	-	-	COX2,COX2_TM,COX_ARM,Cytochrom_C,Cytochrome_CBB3
REGS1_k127_3153988_5	1408473.JHXO01000012_gene284	4.411e-44	168.0	COG0109@1|root,COG0109@2|Bacteria,4NF5A@976|Bacteroidetes	976|Bacteroidetes	O	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	ctaB	-	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
REGS1_k127_3158661_1	1160707.AJIK01000004_gene1213	1.029e-62	220.0	COG1196@1|root,COG1196@2|Bacteria,1TPJV@1239|Firmicutes,4HB89@91061|Bacilli,26DBM@186818|Planococcaceae	91061|Bacilli	D	Required for chromosome condensation and partitioning	smc	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
REGS1_k127_3158661_0	1123376.AUIU01000015_gene427	5.335e-176	555.0	COG2221@1|root,COG2221@2|Bacteria	2|Bacteria	C	Nitrite and sulphite reductase 4Fe-4S	dsrA	-	1.8.99.5	ko:K11180	ko00633,ko00920,ko01100,ko01120,map00633,map00920,map01100,map01120	M00596	R00295,R00861,R08035	RC00065,RC01760	ko00000,ko00001,ko00002,ko01000	-	-	-	NIR_SIR,NIR_SIR_ferr
REGS1_k127_3209622_3	1123376.AUIU01000016_gene208	2.045e-102	346.0	COG0771@1|root,COG0771@2|Bacteria,3J0HT@40117|Nitrospirae	40117|Nitrospirae	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase_C,Mur_ligase_M
REGS1_k127_3209622_1	289376.THEYE_A1323	8.524e-118	391.0	COG0772@1|root,COG0772@2|Bacteria,3J0M8@40117|Nitrospirae	40117|Nitrospirae	D	Cell cycle protein	ftsW	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
REGS1_k127_3209622_2	1123376.AUIU01000016_gene206	1.241e-112	375.0	COG0707@1|root,COG0707@2|Bacteria,3J0JS@40117|Nitrospirae	40117|Nitrospirae	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
REGS1_k127_3209622_0	1123376.AUIU01000016_gene205	1.679e-173	555.0	COG0773@1|root,COG0773@2|Bacteria,3J0D5@40117|Nitrospirae	40117|Nitrospirae	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
REGS1_k127_3261896_1	1158345.JNLL01000001_gene1097	1.563e-88	297.0	COG0226@1|root,COG0226@2|Bacteria,2G3MA@200783|Aquificae	200783|Aquificae	P	Belongs to the PstS family	pstS	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
REGS1_k127_3261896_0	56780.SYN_01009	0.0	1236.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2WIU0@28221|Deltaproteobacteria,2MR2C@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	Cation transporter/ATPase, N-terminus	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
REGS1_k127_3307713_2	1123376.AUIU01000013_gene1812	3.943e-131	425.0	COG3635@1|root,COG3635@2|Bacteria,3J0YA@40117|Nitrospirae	40117|Nitrospirae	G	Metalloenzyme superfamily	-	-	5.4.2.12	ko:K15635	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,PhosphMutase
REGS1_k127_3307713_1	944480.ATUV01000002_gene289	2.54e-161	518.0	COG0527@1|root,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,42NDT@68525|delta/epsilon subdivisions,2WIWZ@28221|Deltaproteobacteria,2M6AW@213113|Desulfurellales	28221|Deltaproteobacteria	E	ACT domain	lysC	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7
REGS1_k127_3307713_0	1123376.AUIU01000011_gene1018	6.201e-236	740.0	COG0119@1|root,COG0119@2|Bacteria,3J0DC@40117|Nitrospirae	40117|Nitrospirae	E	Belongs to the alpha-IPM synthase homocitrate synthase family	-	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
REGS1_k127_3307713_3	1121948.AUAC01000002_gene1544	4.18e-07	53.0	COG0263@1|root,COG0263@2|Bacteria,1MUBG@1224|Proteobacteria,2TRKB@28211|Alphaproteobacteria,43WEA@69657|Hyphomonadaceae	28211|Alphaproteobacteria	E	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate	proB	GO:0003674,GO:0003824,GO:0004349,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0018130,GO:0019202,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.11	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	M00015	R00239	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,PUA
REGS1_k127_3320973_2	264732.Moth_0258	1.045e-77	269.0	COG1660@1|root,COG1660@2|Bacteria,1TPS4@1239|Firmicutes,248KQ@186801|Clostridia,42EYZ@68295|Thermoanaerobacterales	186801|Clostridia	S	Displays ATPase and GTPase activities	yvcJ	-	-	ko:K06958	-	-	-	-	ko00000,ko03019	-	-	-	ATP_bind_2
REGS1_k127_3320973_1	1123376.AUIU01000016_gene196	8.7e-109	363.0	COG1104@1|root,COG1104@2|Bacteria,3J0AX@40117|Nitrospirae	40117|Nitrospirae	E	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	-	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
REGS1_k127_3320973_0	316067.Geob_0830	2.309e-118	386.0	2C2QQ@1|root,32RAW@2|Bacteria,1NSUD@1224|Proteobacteria,42YHI@68525|delta/epsilon subdivisions,2WUH7@28221|Deltaproteobacteria,43TPF@69541|Desulfuromonadales	28221|Deltaproteobacteria	-	-	omcX	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_3337467_2	742823.HMPREF9465_00524	2.236e-19	96.0	COG0204@1|root,COG0204@2|Bacteria,1N2DG@1224|Proteobacteria,2VSJD@28216|Betaproteobacteria,4PQZS@995019|Sutterellaceae	28216|Betaproteobacteria	I	Acyltransferase	plsC	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
REGS1_k127_3337467_1	243231.GSU3130	5.927e-41	159.0	COG3784@1|root,COG3784@2|Bacteria,1Q1FT@1224|Proteobacteria,43788@68525|delta/epsilon subdivisions,2X9VZ@28221|Deltaproteobacteria,43U2G@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF1318)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1318
REGS1_k127_3337467_0	338966.Ppro_1809	2.529e-44	185.0	COG2982@1|root,COG2982@2|Bacteria,1NSFI@1224|Proteobacteria,42YB5@68525|delta/epsilon subdivisions,2WU8N@28221|Deltaproteobacteria,43TA1@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Protein involved in outer membrane biogenesis	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_3338719_1	443143.GM18_0872	2.682e-63	220.0	COG1741@1|root,COG1741@2|Bacteria,1MWIP@1224|Proteobacteria,42N8V@68525|delta/epsilon subdivisions,2WJWB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
REGS1_k127_3338719_5	1392838.AWNM01000095_gene3173	8.277e-28	117.0	2ECF7@1|root,336DF@2|Bacteria,1NZI6@1224|Proteobacteria,2W3M2@28216|Betaproteobacteria,3T7TU@506|Alcaligenaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_3338719_2	289376.THEYE_A0959	9.328e-56	201.0	COG0811@1|root,COG0811@2|Bacteria,3J0PX@40117|Nitrospirae	40117|Nitrospirae	U	MotA/TolQ/ExbB proton channel family	-	-	-	ko:K03562	ko01120,map01120	-	-	-	ko00000,ko02000	1.A.30.2.2	-	-	MotA_ExbB
REGS1_k127_3338719_4	289376.THEYE_A0958	6.069e-37	144.0	COG0848@1|root,COG0848@2|Bacteria,3J0T6@40117|Nitrospirae	40117|Nitrospirae	U	Biopolymer transport protein ExbD/TolR	-	-	-	ko:K03560	-	-	-	-	ko00000,ko02000	1.A.30.2.2	-	-	ExbD
REGS1_k127_3338719_6	1123376.AUIU01000004_gene1155	1.322e-14	83.0	COG0810@1|root,COG0810@2|Bacteria	2|Bacteria	M	energy transducer activity	tolA	-	-	ko:K03646,ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1,2.C.1.2	-	-	TonB_2
REGS1_k127_3338719_0	443143.GM18_0574	6.581e-74	267.0	COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,42PHP@68525|delta/epsilon subdivisions,2WIXN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	U	Involved in the TonB-independent uptake of proteins	tolB	GO:0003674,GO:0005215,GO:0006810,GO:0008150,GO:0019534,GO:0022857,GO:0051179,GO:0051234,GO:0055085,GO:1901998	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40,TolB_N
REGS1_k127_3338719_3	289376.THEYE_A2098	6.579e-40	154.0	COG2885@1|root,COG2885@2|Bacteria,3J17Q@40117|Nitrospirae	40117|Nitrospirae	M	Belongs to the ompA family	-	-	-	ko:K03640	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	OmpA
REGS1_k127_3358572_1	5911.EAR92058	1.696e-07	61.0	COG3914@1|root,KOG0198@1|root,KOG0198@2759|Eukaryota,KOG4626@2759|Eukaryota	2759|Eukaryota	O	protein N-acetylglucosaminyltransferase activity	-	GO:0000166,GO:0001101,GO:0003008,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0004694,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006417,GO:0006446,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0007155,GO:0007165,GO:0007588,GO:0008144,GO:0008150,GO:0008152,GO:0009267,GO:0009605,GO:0009889,GO:0009892,GO:0009893,GO:0009894,GO:0009895,GO:0009987,GO:0009991,GO:0010035,GO:0010468,GO:0010556,GO:0010604,GO:0010605,GO:0010608,GO:0010628,GO:0010646,GO:0010998,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0019219,GO:0019222,GO:0019538,GO:0019932,GO:0019933,GO:0019935,GO:0022610,GO:0023052,GO:0030421,GO:0030554,GO:0030587,GO:0031152,GO:0031156,GO:0031157,GO:0031158,GO:0031323,GO:0031324,GO:0031326,GO:0031329,GO:0031330,GO:0031589,GO:0031667,GO:0031668,GO:0031669,GO:0032101,GO:0032104,GO:0032107,GO:0032268,GO:0032501,GO:0032502,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034248,GO:0035556,GO:0035639,GO:0036094,GO:0036211,GO:0042221,GO:0042594,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043487,GO:0043488,GO:0043489,GO:0043555,GO:0043558,GO:0043900,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0044764,GO:0045182,GO:0045934,GO:0048255,GO:0048518,GO:0048519,GO:0048523,GO:0048583,GO:0048856,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051246,GO:0051252,GO:0051253,GO:0051703,GO:0051704,GO:0051716,GO:0060176,GO:0060255,GO:0061013,GO:0065007,GO:0065008,GO:0071496,GO:0071704,GO:0071944,GO:0080090,GO:0080134,GO:0080135,GO:0090702,GO:0097159,GO:0097367,GO:0098609,GO:0098630,GO:0098743,GO:0099120,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1902369,GO:1902373,GO:1902617,GO:1903311,GO:1903312,GO:2000112	2.7.11.1,4.2.99.18	ko:K05391,ko:K10773,ko:K16196	ko03410,ko04138,ko04140,ko04141,ko04626,ko05160,ko05162,ko05164,ko05168,ko05169,map03410,map04138,map04140,map04141,map04626,map05160,map05162,map05164,map05168,map05169	-	-	-	ko00000,ko00001,ko01000,ko01001,ko03400,ko04040	1.A.1.5	-	-	HGTP_anticodon2,Pkinase,TPR_1,TPR_11,TPR_16,TPR_17,TPR_19,TPR_2,TPR_8,tRNA-synt_His,zf-B_box
REGS1_k127_3358572_0	289376.THEYE_A0216	1.477e-27	119.0	2DU0J@1|root,32UW9@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_3360716_2	697303.Thewi_0152	7.944e-10	60.0	COG3872@1|root,COG3872@2|Bacteria,1TPBU@1239|Firmicutes,25C8E@186801|Clostridia,42F2N@68295|Thermoanaerobacterales	186801|Clostridia	S	Protein of unknown function (DUF1385)	prmC	-	-	-	-	-	-	-	-	-	-	-	DUF1385,MTS
REGS1_k127_3360716_0	289376.THEYE_A0369	1.658e-155	497.0	COG0216@1|root,COG0216@2|Bacteria,3J0F6@40117|Nitrospirae	40117|Nitrospirae	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
REGS1_k127_3360716_1	289376.THEYE_A0370	7.628e-69	247.0	COG2890@1|root,COG2890@2|Bacteria,3J0N5@40117|Nitrospirae	40117|Nitrospirae	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	-	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0044424,GO:0044444,GO:0044464	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS
REGS1_k127_3363259_10	419665.Maeo_0964	0.0002881	46.0	COG1553@1|root,arCOG02068@2157|Archaea,2Y0VW@28890|Euryarchaeota	28890|Euryarchaeota	P	DsrE/DsrF-like family	-	-	-	ko:K07235	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DrsE
REGS1_k127_3363259_8	471881.PROPEN_01575	4.923e-06	53.0	COG2168@1|root,COG2168@2|Bacteria,1NGF3@1224|Proteobacteria,1SGPI@1236|Gammaproteobacteria,3Z2XC@583|Proteus	1236|Gammaproteobacteria	J	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions	tusB	GO:0002097,GO:0002098,GO:0002143,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1902494,GO:1990228,GO:1990234	-	ko:K07237	ko04122,map04122	-	-	-	ko00000,ko00001,ko03016	-	-	-	DsrH
REGS1_k127_3363259_6	338963.Pcar_2069	3.712e-16	83.0	COG1651@1|root,COG1651@2|Bacteria,1RD39@1224|Proteobacteria,42QRZ@68525|delta/epsilon subdivisions,2WMZS@28221|Deltaproteobacteria,43SGM@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process	-	-	5.3.4.1	ko:K03981	-	-	-	-	ko00000,ko01000,ko02044,ko03110	3.A.7.11.1	-	-	DsbC_N,Thioredoxin_2
REGS1_k127_3363259_5	1232410.KI421415_gene3019	1.499e-32	129.0	COG1651@1|root,COG1651@2|Bacteria,1RD39@1224|Proteobacteria,42QRZ@68525|delta/epsilon subdivisions,2WMZS@28221|Deltaproteobacteria,43SGM@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process	-	-	5.3.4.1	ko:K03981	-	-	-	-	ko00000,ko01000,ko02044,ko03110	3.A.7.11.1	-	-	DsbC_N,Thioredoxin_2
REGS1_k127_3363259_0	56780.SYN_02798	3.196e-267	842.0	COG0550@1|root,COG0551@1|root,COG0550@2|Bacteria,COG0551@2|Bacteria,1MUFZ@1224|Proteobacteria,42MM9@68525|delta/epsilon subdivisions,2WJTT@28221|Deltaproteobacteria,2MQTZ@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,zf-C4_Topoisom
REGS1_k127_3363259_3	1123376.AUIU01000014_gene701	6.925e-96	326.0	COG0758@1|root,COG0758@2|Bacteria,3J0Q8@40117|Nitrospirae	40117|Nitrospirae	L	DNA recombination-mediator protein A	-	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A,HHH_5
REGS1_k127_3363259_1	1123376.AUIU01000014_gene702	9.475e-194	610.0	COG0137@1|root,COG0137@2|Bacteria,3J0BU@40117|Nitrospirae	40117|Nitrospirae	E	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	-	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
REGS1_k127_3363259_4	237368.SCABRO_03716	5.75e-37	143.0	COG0735@1|root,COG0735@2|Bacteria,2IZJY@203682|Planctomycetes	203682|Planctomycetes	P	Belongs to the Fur family	-	-	-	ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
REGS1_k127_3363259_2	404589.Anae109_2250	7.903e-167	541.0	COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,42PVA@68525|delta/epsilon subdivisions,2WJ10@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	transporter of a GTP-driven Fe(2 ) uptake system	feoB-1	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
REGS1_k127_3382720_0	247490.KSU1_C0895	8.204e-53	199.0	COG2203@1|root,COG3829@1|root,COG4191@1|root,COG5002@1|root,COG2203@2|Bacteria,COG3829@2|Bacteria,COG4191@2|Bacteria,COG5002@2|Bacteria,2IZWU@203682|Planctomycetes	203682|Planctomycetes	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg
REGS1_k127_3382720_1	289376.THEYE_A0132	5.885e-46	168.0	COG0234@1|root,COG0234@2|Bacteria	2|Bacteria	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009987,GO:0010033,GO:0035966,GO:0042221,GO:0042802,GO:0043167,GO:0043169,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0061077	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
REGS1_k127_3382720_4	368407.Memar_2058	4.097e-15	80.0	COG0599@1|root,arCOG02148@2157|Archaea,2Y12T@28890|Euryarchaeota,2N9VC@224756|Methanomicrobia	224756|Methanomicrobia	S	TIGRFAM alkylhydroperoxidase like protein, AhpD family	-	-	-	-	-	-	-	-	-	-	-	-	CMD
REGS1_k127_3382720_3	1379281.AVAG01000018_gene1019	4.478e-24	102.0	COG0694@1|root,COG0694@2|Bacteria,1MVQ1@1224|Proteobacteria,42V85@68525|delta/epsilon subdivisions,2WR93@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	PFAM nitrogen-fixing NifU domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Nfu_N,NifU
REGS1_k127_3382720_2	502025.Hoch_0090	2.677e-37	147.0	COG2353@1|root,COG2353@2|Bacteria	2|Bacteria	O	YceI-like domain	-	-	-	-	-	-	-	-	-	-	-	-	YceI
REGS1_k127_3395932_1	635013.TherJR_0525	4.728e-226	706.0	COG0427@1|root,COG1670@1|root,COG0427@2|Bacteria,COG1670@2|Bacteria,1TPHC@1239|Firmicutes,247V0@186801|Clostridia,260IW@186807|Peptococcaceae	186801|Clostridia	C	PFAM Acetyl-CoA hydrolase transferase	cat	-	-	ko:K18122	ko00650,ko01100,ko01200,map00650,map01100,map01200	-	R05336	RC00012,RC00014	ko00000,ko00001,ko01000	-	-	-	AcetylCoA_hyd_C,AcetylCoA_hydro
REGS1_k127_3395932_5	637389.Acaty_c0435	3.279e-76	278.0	COG1164@1|root,COG1164@2|Bacteria,1MXAC@1224|Proteobacteria,1S6M5@1236|Gammaproteobacteria,2NBV4@225057|Acidithiobacillales	225057|Acidithiobacillales	E	Oligopeptidase F	-	-	-	ko:K08602	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3,Peptidase_M3_N
REGS1_k127_3395932_2	56780.SYN_00221	1.132e-143	466.0	COG0116@1|root,COG0116@2|Bacteria,1MUQM@1224|Proteobacteria,42NJ1@68525|delta/epsilon subdivisions,2WJ5S@28221|Deltaproteobacteria,2MQHY@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	Putative RNA methylase family UPF0020	rlmL	-	2.1.1.173,2.1.1.264	ko:K07444,ko:K12297	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM,THUMP,UPF0020
REGS1_k127_3395932_6	243231.GSU0317	3.725e-70	245.0	28PU4@1|root,2ZCF6@2|Bacteria,1RBK2@1224|Proteobacteria,43B3D@68525|delta/epsilon subdivisions,2WVDQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_3395932_4	909663.KI867150_gene711	3.156e-88	297.0	COG0545@1|root,COG0545@2|Bacteria,1RDA1@1224|Proteobacteria,43A29@68525|delta/epsilon subdivisions,2X21K@28221|Deltaproteobacteria,2MS4J@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	FKBP-type peptidyl-prolyl cis-trans isomerase	-	-	-	-	-	-	-	-	-	-	-	-	FKBP_C
REGS1_k127_3395932_0	795359.TOPB45_0633	3.914e-252	796.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,2GH97@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	C	Succinyl-CoA ligase like flavodoxin domain	-	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
REGS1_k127_3395932_3	161156.JQKW01000001_gene1434	1.073e-100	338.0	COG0857@1|root,COG0857@2|Bacteria,2GHJ8@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	C	DRTGG domain	-	-	-	ko:K06873	-	-	-	-	ko00000	-	-	-	AAA_26,DRTGG
REGS1_k127_3395932_7	1123376.AUIU01000015_gene371	2.814e-19	88.0	COG1611@1|root,COG1611@2|Bacteria,3J169@40117|Nitrospirae	40117|Nitrospirae	S	Possible lysine decarboxylase	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
REGS1_k127_3411717_0	330214.NIDE1676	1.604e-113	374.0	COG1066@1|root,COG1066@2|Bacteria,3J0BP@40117|Nitrospirae	40117|Nitrospirae	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	ATPase,ChlI,Lon_C
REGS1_k127_3411717_1	1392491.JIAE01000001_gene168	1.83e-56	206.0	COG0351@1|root,COG0351@2|Bacteria,1TQ4A@1239|Firmicutes,2483H@186801|Clostridia,3WGHQ@541000|Ruminococcaceae	186801|Clostridia	H	Phosphomethylpyrimidine kinase	thiD	-	2.5.1.3,2.7.1.35,2.7.1.49,2.7.4.7	ko:K00868,ko:K00941,ko:K14153	ko00730,ko00750,ko01100,map00730,map00750,map01100	M00127	R00174,R01909,R02493,R03223,R03471,R04509,R10712	RC00002,RC00017,RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	Phos_pyr_kin
REGS1_k127_3413217_1	316067.Geob_0020	1.104e-127	414.0	COG1281@1|root,COG1281@2|Bacteria,1MUMU@1224|Proteobacteria,42Q9R@68525|delta/epsilon subdivisions,2WKU4@28221|Deltaproteobacteria,43SCY@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress	hslO	-	-	ko:K04083	-	-	-	-	ko00000,ko03110	-	-	-	HSP33
REGS1_k127_3413217_2	933262.AXAM01000213_gene1883	3.156e-52	186.0	2DN2Z@1|root,32V89@2|Bacteria,1N3VG@1224|Proteobacteria,42TI7@68525|delta/epsilon subdivisions,2WQNX@28221|Deltaproteobacteria,2MKM9@213118|Desulfobacterales	28221|Deltaproteobacteria	S	zinc-ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	zf-ribbon_3
REGS1_k127_3413217_0	1121918.ARWE01000001_gene1679	6.541e-147	477.0	COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,42NF8@68525|delta/epsilon subdivisions,2WKBA@28221|Deltaproteobacteria,43TAY@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
REGS1_k127_3414189_0	316067.Geob_0763	5.874e-117	382.0	COG3245@1|root,COG3245@2|Bacteria,1RJCX@1224|Proteobacteria	1224|Proteobacteria	C	Cytochrome c7 and related cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C7
REGS1_k127_3414189_1	316067.Geob_0764	7.561e-85	292.0	COG3245@1|root,COG3245@2|Bacteria,1RJCX@1224|Proteobacteria	1224|Proteobacteria	C	Cytochrome c7 and related cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C7
REGS1_k127_3414189_2	1121918.ARWE01000001_gene827	7.59e-84	292.0	COG3005@1|root,COG3005@2|Bacteria,1R8V7@1224|Proteobacteria,42YES@68525|delta/epsilon subdivisions,2WU80@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	TIGRFAM cytochrome C family protein	-	-	-	-	-	-	-	-	-	-	-	-	Paired_CXXCH_1
REGS1_k127_3420363_3	330214.NIDE2538	7.197e-64	224.0	COG2065@1|root,COG2065@2|Bacteria,3J0JX@40117|Nitrospirae	40117|Nitrospirae	F	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant	pyrR	-	2.4.2.9	ko:K02825	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000,ko03000	-	-	-	Pribosyltran
REGS1_k127_3420363_2	485916.Dtox_2355	3.172e-120	392.0	COG0540@1|root,COG0540@2|Bacteria,1TQ96@1239|Firmicutes,2496D@186801|Clostridia,260AV@186807|Peptococcaceae	186801|Clostridia	F	Belongs to the ATCase OTCase family	pyrB	-	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
REGS1_k127_3420363_1	330214.NIDE2540	2.394e-154	499.0	COG0044@1|root,COG0044@2|Bacteria,3J0D7@40117|Nitrospirae	40117|Nitrospirae	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	pyrC	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
REGS1_k127_3420363_0	289376.THEYE_A1240	6.732e-157	504.0	COG0505@1|root,COG0505@2|Bacteria,3J0CS@40117|Nitrospirae	40117|Nitrospirae	F	Carbamoyl-phosphate synthase small chain, CPSase domain	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
REGS1_k127_342290_5	243231.GSU1051	2.334e-08	61.0	294M8@1|root,2ZS0P@2|Bacteria,1PAVG@1224|Proteobacteria,433BR@68525|delta/epsilon subdivisions,2WXV1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PilZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PilZ
REGS1_k127_342290_0	671143.DAMO_1167	1.855e-290	930.0	COG2982@1|root,COG2982@2|Bacteria	2|Bacteria	M	Protein involved in outer membrane biogenesis	-	-	-	-	-	-	-	-	-	-	-	-	DUF748
REGS1_k127_342290_2	237368.SCABRO_01237	4.075e-85	287.0	2C8XG@1|root,2Z7PK@2|Bacteria,2J377@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF4197)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4197
REGS1_k127_342290_3	909663.KI867149_gene3383	3.631e-60	211.0	COG1970@1|root,COG1970@2|Bacteria,1RHG8@1224|Proteobacteria,42RNC@68525|delta/epsilon subdivisions,2WP7G@28221|Deltaproteobacteria,2MRIV@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Large-conductance mechanosensitive channel, MscL	mscL	GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0032535,GO:0042592,GO:0044425,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0090066	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
REGS1_k127_342290_4	1122143.AUEG01000003_gene965	6.216e-16	85.0	COG1247@1|root,COG1247@2|Bacteria,1VA2F@1239|Firmicutes,4HJB4@91061|Bacilli,27HXA@186828|Carnobacteriaceae	91061|Bacilli	M	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
REGS1_k127_342290_1	289376.THEYE_A0769	1.518e-176	560.0	COG0281@1|root,COG0281@2|Bacteria,3J0WV@40117|Nitrospirae	40117|Nitrospirae	C	Malic enzyme, NAD binding domain	-	-	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	-	R00214	RC00105	ko00000,ko00001,ko01000	-	-	-	ACT_4,Malic_M,malic
REGS1_k127_3443333_3	439235.Dalk_0099	2.435e-13	72.0	2ARUS@1|root,31H6C@2|Bacteria,1RFAK@1224|Proteobacteria,42SPB@68525|delta/epsilon subdivisions,2WPJK@28221|Deltaproteobacteria,2MKD1@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Type I restriction enzyme R protein N terminus (HSDR_N)	-	-	-	-	-	-	-	-	-	-	-	-	HSDR_N_2
REGS1_k127_3443333_1	289376.THEYE_A1888	4.145e-76	262.0	COG1145@1|root,COG1145@2|Bacteria	2|Bacteria	C	4fe-4S ferredoxin, iron-sulfur binding domain protein	napF	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006950,GO:0006979,GO:0008150,GO:0044424,GO:0044464,GO:0050896	-	ko:K02572	-	-	-	-	ko00000	-	-	-	Fer4,Fer4_4,Fer4_6,Fer4_7,Fer4_9
REGS1_k127_3443333_2	439235.Dalk_0099	1.718e-27	120.0	2ARUS@1|root,31H6C@2|Bacteria,1RFAK@1224|Proteobacteria,42SPB@68525|delta/epsilon subdivisions,2WPJK@28221|Deltaproteobacteria,2MKD1@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Type I restriction enzyme R protein N terminus (HSDR_N)	-	-	-	-	-	-	-	-	-	-	-	-	HSDR_N_2
REGS1_k127_3443333_0	1123393.KB891317_gene2190	4.138e-181	582.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2VJJV@28216|Betaproteobacteria,1KSRR@119069|Hydrogenophilales	119069|Hydrogenophilales	EH	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain	-	-	-	-	-	-	-	-	-	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
REGS1_k127_3459080_0	883.DvMF_3023	1.534e-152	485.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,42M8M@68525|delta/epsilon subdivisions,2WJE2@28221|Deltaproteobacteria,2M80K@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	TIGRFAM Ammonium transporter	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
REGS1_k127_3459080_2	269799.Gmet_1351	1.905e-48	175.0	COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,42SJJ@68525|delta/epsilon subdivisions,2WP4E@28221|Deltaproteobacteria,43V1G@69541|Desulfuromonadales	28221|Deltaproteobacteria	K	Belongs to the P(II) protein family	glnB	-	-	ko:K04751	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
REGS1_k127_3459080_1	693661.Arcve_0331	7.182e-91	310.0	COG4756@1|root,arCOG04052@2157|Archaea,2XWD2@28890|Euryarchaeota	28890|Euryarchaeota	S	Protein of unknown function (DUF1646)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1646
REGS1_k127_3459080_3	1232437.KL661961_gene3039	2.685e-29	124.0	COG2905@1|root,COG2905@2|Bacteria,1QTTR@1224|Proteobacteria,42TN6@68525|delta/epsilon subdivisions,2WPMT@28221|Deltaproteobacteria,2MKDM@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
REGS1_k127_3459080_4	1089553.Tph_c14890	2.477e-10	63.0	COG1905@1|root,COG1905@2|Bacteria,1V4BY@1239|Firmicutes,24HER@186801|Clostridia,42ICF@68295|Thermoanaerobacterales	186801|Clostridia	C	Thioredoxin-like [2Fe-2S] ferredoxin	-	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
REGS1_k127_3465018_7	289376.THEYE_A1334	0.0005763	44.0	COG1472@1|root,COG1472@2|Bacteria,3J0MK@40117|Nitrospirae	40117|Nitrospirae	G	Glycosyl hydrolase family 3 N terminal domain	-	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3
REGS1_k127_3465018_6	1125863.JAFN01000001_gene1445	1.015e-13	76.0	COG4393@1|root,COG4393@2|Bacteria,1R507@1224|Proteobacteria,42NQA@68525|delta/epsilon subdivisions,2WQ0C@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Predicted membrane protein (DUF2318)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2318
REGS1_k127_3465018_1	289376.THEYE_A1839	6.753e-108	357.0	COG0552@1|root,COG0552@2|Bacteria,3J0GY@40117|Nitrospirae	40117|Nitrospirae	D	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
REGS1_k127_3465018_2	913865.DOT_6248	1.274e-62	217.0	COG5561@1|root,COG5561@2|Bacteria,1VJ0D@1239|Firmicutes,24RTC@186801|Clostridia,265JS@186807|Peptococcaceae	186801|Clostridia	S	CGGC	-	-	-	-	-	-	-	-	-	-	-	-	CGGC
REGS1_k127_3465018_3	767817.Desgi_0205	4.873e-55	196.0	COG0826@1|root,COG0826@2|Bacteria	2|Bacteria	O	peptidase U32	-	-	-	-	-	-	-	-	-	-	-	-	DUF3656,DUF3795,Peptidase_U32
REGS1_k127_3465018_5	269799.Gmet_3079	7.099e-21	93.0	2ER59@1|root,33IQV@2|Bacteria,1NMF6@1224|Proteobacteria,42Y36@68525|delta/epsilon subdivisions,2WT0Q@28221|Deltaproteobacteria,43VTT@69541|Desulfuromonadales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_3465018_0	123214.PERMA_1556	0.0	1156.0	COG5492@1|root,COG5492@2|Bacteria	2|Bacteria	N	domain, Protein	-	-	3.2.1.52	ko:K12373	ko00511,ko00513,ko00520,ko00531,ko00603,ko00604,ko01100,ko04142,map00511,map00513,map00520,map00531,map00603,map00604,map01100,map04142	M00079	R00022,R06004,R11316	RC00049	ko00000,ko00001,ko00002,ko01000,ko03110	-	GH20	-	Amidase_3,Big_2,F5_F8_type_C,Flg_new,Glyco_hydro_20,Glyco_hydro_20b,LRR_5,Peptidase_S8,RicinB_lectin_2,SLH
REGS1_k127_347844_0	706587.Desti_3124	8.422e-201	642.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2WIPP@28221|Deltaproteobacteria,2MQ93@213462|Syntrophobacterales	28221|Deltaproteobacteria	NU	TIGRFAM type IV-A pilus assembly ATPase PilB	pilB	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N,cNMP_binding
REGS1_k127_347844_1	1125863.JAFN01000001_gene2903	9.747e-141	450.0	COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,42M7F@68525|delta/epsilon subdivisions,2WIMF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	NU	twitching motility protein	pilT-4	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
REGS1_k127_347844_3	671143.DAMO_3012	1.178e-25	108.0	COG2805@1|root,COG2805@2|Bacteria,2NNR7@2323|unclassified Bacteria	2|Bacteria	NU	Type II/IV secretion system protein	pilT	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
REGS1_k127_347844_2	502025.Hoch_4826	4.725e-110	368.0	COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,42NES@68525|delta/epsilon subdivisions,2WJ0V@28221|Deltaproteobacteria,2YU38@29|Myxococcales	28221|Deltaproteobacteria	NU	Type II secretion system (T2SS), protein F	pilC	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
REGS1_k127_347844_4	316067.Geob_3371	1.643e-19	97.0	COG5000@1|root,COG5000@2|Bacteria,1QVAT@1224|Proteobacteria,43BPZ@68525|delta/epsilon subdivisions,2X717@28221|Deltaproteobacteria,43TK3@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Sensor histidine kinase PilS, PAS domain-containing	pilS	-	2.7.13.3	ko:K02668,ko:K07709	ko02020,map02020	M00499,M00501	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	HATPase_c,HisKA,PAS,PAS_4
REGS1_k127_3494068_4	1121423.JONT01000009_gene1453	3.146e-66	244.0	COG3383@1|root,COG3383@2|Bacteria,1TT6D@1239|Firmicutes,24YN9@186801|Clostridia,267CA@186807|Peptococcaceae	186801|Clostridia	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	fdhA	-	1.17.1.10,1.17.1.9	ko:K00123,ko:K05299	ko00630,ko00680,ko00720,ko01100,ko01120,ko01200,map00630,map00680,map00720,map01100,map01120,map01200	M00377	R00134,R00519	RC02796	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_4,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
REGS1_k127_3494068_3	747365.Thena_1751	6.291e-129	421.0	COG1005@1|root,COG1005@2|Bacteria,1TQNU@1239|Firmicutes,25E6Z@186801|Clostridia,42FT6@68295|Thermoanaerobacterales	186801|Clostridia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
REGS1_k127_3494068_5	161156.JQKW01000009_gene1590	1.545e-42	162.0	COG1143@1|root,COG1143@2|Bacteria,2GHTR@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
REGS1_k127_3494068_6	667014.Thein_1631	3.343e-41	157.0	COG0839@1|root,COG0839@2|Bacteria,2GHWH@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	C	NADH-ubiquinone/plastoquinone oxidoreductase chain 6	-	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
REGS1_k127_3494068_7	517418.Ctha_2484	8.289e-31	123.0	COG0713@1|root,COG0713@2|Bacteria,1FFEB@1090|Chlorobi	1090|Chlorobi	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
REGS1_k127_3494068_0	1123376.AUIU01000014_gene642	7.249e-245	771.0	COG1009@1|root,COG1009@2|Bacteria,3J0AN@40117|Nitrospirae	40117|Nitrospirae	CP	NADH-quinone oxidoreductase	-	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
REGS1_k127_3494068_1	525146.Ddes_1656	1.304e-191	611.0	COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,42NGD@68525|delta/epsilon subdivisions,2WJDC@28221|Deltaproteobacteria,2M89W@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M	nuoM-1	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q5_N,Proton_antipo_M
REGS1_k127_3494068_2	1123371.ATXH01000017_gene653	2.364e-137	452.0	COG1007@1|root,COG1007@2|Bacteria,2GH6M@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
REGS1_k127_3494658_3	555779.Dthio_PD3232	3.378e-27	113.0	COG1905@1|root,COG1905@2|Bacteria,1RHBU@1224|Proteobacteria,42U8S@68525|delta/epsilon subdivisions,2WQ8V@28221|Deltaproteobacteria,2MAD2@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Thioredoxin-like [2Fe-2S] ferredoxin	nuoE-1	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
REGS1_k127_3494658_0	639282.DEFDS_1980	8.261e-244	766.0	COG1894@1|root,COG1894@2|Bacteria,2GF0Z@200930|Deferribacteres	200930|Deferribacteres	C	PFAM Respiratory-chain NADH dehydrogenase domain 51 kDa subunit	-	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
REGS1_k127_3494658_1	555779.Dthio_PD3230	7.227e-149	478.0	COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,43BP2@68525|delta/epsilon subdivisions,2WK8X@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	molybdopterin oxidoreductase Fe4S4 region	sfrA	-	1.17.1.10	ko:K05299	ko00680,ko00720,ko01100,ko01120,ko01200,map00680,map00720,map01100,map01120,map01200	M00377	R00134	RC02796	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_4,Fer4_10,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
REGS1_k127_3494658_2	207559.Dde_0473	1.288e-37	143.0	COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,42SPZ@68525|delta/epsilon subdivisions,2WIV9@28221|Deltaproteobacteria,2M8TZ@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.17.1.10,1.17.1.9	ko:K00123,ko:K05299	ko00630,ko00680,ko00720,ko01100,ko01120,ko01200,map00630,map00680,map00720,map01100,map01120,map01200	M00377	R00134,R00519	RC02796	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_4,Fer4,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
REGS1_k127_3500330_2	1121405.dsmv_0806	0.0001619	49.0	2F35T@1|root,33W0F@2|Bacteria,1NVX1@1224|Proteobacteria,42ZTR@68525|delta/epsilon subdivisions,2WVA2@28221|Deltaproteobacteria,2MNJ3@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl
REGS1_k127_3500330_0	289376.THEYE_A0690	5.534e-153	488.0	COG0113@1|root,COG0113@2|Bacteria,3J0DV@40117|Nitrospirae	40117|Nitrospirae	H	Delta-aminolevulinic acid dehydratase	hemB	-	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
REGS1_k127_3500330_1	289376.THEYE_A0691	6.979e-31	124.0	COG0316@1|root,COG0316@2|Bacteria,3J0TZ@40117|Nitrospirae	40117|Nitrospirae	S	Belongs to the HesB IscA family	-	-	-	ko:K15724	-	-	-	-	ko00000	-	-	-	Fe-S_biosyn
REGS1_k127_3552760_5	330214.NIDE4197	4.465e-16	81.0	COG2199@1|root,COG3706@2|Bacteria	2|Bacteria	T	GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GGDEF,HATPase_c,HisKA,PAS,Response_reg
REGS1_k127_3552760_2	880072.Desac_1033	1.765e-117	392.0	COG0612@1|root,COG0612@2|Bacteria,1MU6R@1224|Proteobacteria,42M74@68525|delta/epsilon subdivisions,2X1XQ@28221|Deltaproteobacteria,2MRAF@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Peptidase M16 domain protein	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
REGS1_k127_3552760_1	671143.DAMO_0005	3.619e-136	446.0	COG0612@1|root,COG0612@2|Bacteria,2NP50@2323|unclassified Bacteria	2|Bacteria	S	Insulinase (Peptidase family M16)	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
REGS1_k127_3552760_3	289376.THEYE_A0972	1.336e-59	216.0	COG0483@1|root,COG0483@2|Bacteria	2|Bacteria	G	inositol monophosphate 1-phosphatase activity	suhB	-	3.1.3.25,3.1.3.7	ko:K01082,ko:K01092	ko00521,ko00562,ko00920,ko01100,ko01120,ko01130,ko04070,map00521,map00562,map00920,map01100,map01120,map01130,map04070	M00131	R00188,R00508,R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	Inositol_P
REGS1_k127_3552760_0	247490.KSU1_C1682	1.071e-258	807.0	COG0058@1|root,COG0058@2|Bacteria,2IY0J@203682|Planctomycetes	203682|Planctomycetes	G	COG0058 Glucan phosphorylase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphorylase
REGS1_k127_3552760_4	330214.NIDE1012	1.275e-26	113.0	COG1714@1|root,COG1714@2|Bacteria,3J0U3@40117|Nitrospirae	40117|Nitrospirae	S	RDD family	-	-	-	-	-	-	-	-	-	-	-	-	RDD
REGS1_k127_3567957_0	1121440.AUMA01000009_gene561	2.063e-260	831.0	COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,1MU0R@1224|Proteobacteria,42MW3@68525|delta/epsilon subdivisions,2WIXV@28221|Deltaproteobacteria,2MAEK@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	Pyruvate phosphate dikinase, PEP/pyruvate binding domain	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
REGS1_k127_3579569_4	55529.EKX40827	5.17e-63	229.0	COG0574@1|root,2QS3J@2759|Eukaryota	2759|Eukaryota	G	6-phosphoglucan, water dikinase activity	PWD1	GO:0000272,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005976,GO:0005982,GO:0005983,GO:0006073,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009251,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009987,GO:0016052,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016781,GO:0019200,GO:0019538,GO:0036211,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044260,GO:0044262,GO:0044264,GO:0044267,GO:0044275,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046777,GO:0046835,GO:0051752,GO:0071704,GO:1901564,GO:1901575	2.7.9.5	ko:K15535	-	-	-	-	ko00000,ko01000	-	-	-	CBM_20,PPDK_N
REGS1_k127_3579569_1	1283300.ATXB01000001_gene664	1.506e-162	539.0	COG0366@1|root,COG0366@2|Bacteria,1MWBZ@1224|Proteobacteria,1RYKS@1236|Gammaproteobacteria,1XFWC@135618|Methylococcales	135618|Methylococcales	G	Alpha amylase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	hDGE_amylase
REGS1_k127_3579569_9	289376.THEYE_A0802	3.07e-29	124.0	COG1734@1|root,COG1734@2|Bacteria,3J0TH@40117|Nitrospirae	40117|Nitrospirae	T	Prokaryotic dksA/traR C4-type zinc finger	-	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
REGS1_k127_3579569_6	289376.THEYE_A0345	1.659e-54	199.0	COG1381@1|root,COG1381@2|Bacteria,3J0S8@40117|Nitrospirae	40117|Nitrospirae	L	Involved in DNA repair and RecF pathway recombination	recO	-	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
REGS1_k127_3579569_3	289376.THEYE_A0344	4.068e-72	245.0	COG1259@1|root,COG1259@2|Bacteria,3J0RC@40117|Nitrospirae	40117|Nitrospirae	S	Bifunctional nuclease	-	-	-	ko:K08999	-	-	-	-	ko00000	-	-	-	DNase-RNase
REGS1_k127_3579569_2	289376.THEYE_A0343	6.737e-105	348.0	COG1159@1|root,COG1159@2|Bacteria,3J0IB@40117|Nitrospirae	40117|Nitrospirae	S	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism	era	-	-	ko:K03595	-	-	-	-	ko00000,ko03009,ko03029	-	-	-	KH_2,MMR_HSR1
REGS1_k127_3579569_0	289376.THEYE_A0342	6.416e-183	580.0	COG0436@1|root,COG0436@2|Bacteria,3J0EV@40117|Nitrospirae	40117|Nitrospirae	E	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
REGS1_k127_3579569_5	123214.PERMA_0133	6.18e-61	213.0	COG0450@1|root,COG0450@2|Bacteria,2G3ZJ@200783|Aquificae	200783|Aquificae	O	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	ahpC	-	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	1-cysPrx_C,AhpC-TSA
REGS1_k127_3579569_11	589865.DaAHT2_2091	5.767e-16	78.0	COG0450@1|root,COG0450@2|Bacteria,1MWPY@1224|Proteobacteria,42MAJ@68525|delta/epsilon subdivisions,2WNIG@28221|Deltaproteobacteria,2MJSH@213118|Desulfobacterales	28221|Deltaproteobacteria	O	AhpC/TSA family	-	-	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	1-cysPrx_C,AhpC-TSA
REGS1_k127_3579569_8	667014.Thein_0096	5.061e-39	149.0	2E978@1|root,333FR@2|Bacteria,2GIHH@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_3579569_7	56780.SYN_02524	2.321e-53	190.0	COG0735@1|root,COG0735@2|Bacteria,1N0HW@1224|Proteobacteria,42TU6@68525|delta/epsilon subdivisions,2WPZ1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Belongs to the Fur family	-	-	-	ko:K03711,ko:K09825	-	-	-	-	ko00000,ko03000	-	-	-	FUR
REGS1_k127_3579569_10	269799.Gmet_1930	4.481e-16	78.0	COG1271@1|root,COG1271@2|Bacteria,1MV60@1224|Proteobacteria,42MB8@68525|delta/epsilon subdivisions,2WIW7@28221|Deltaproteobacteria,43UFE@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Cytochrome bd terminal oxidase subunit I	cydA	-	1.10.3.14	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_I
REGS1_k127_3590915_0	555779.Dthio_PD3229	8.697e-168	537.0	COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,42SPZ@68525|delta/epsilon subdivisions,2WIV9@28221|Deltaproteobacteria,2M8TZ@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
REGS1_k127_3590915_1	289376.THEYE_A0692	2.78e-69	243.0	COG1526@1|root,COG1526@2|Bacteria	2|Bacteria	C	Mo-molybdopterin cofactor metabolic process	fdhD	-	-	ko:K02379	-	-	-	-	ko00000	-	-	-	FdhD-NarQ
REGS1_k127_3590915_4	1118235.CAJH01000041_gene2633	4.911e-05	54.0	COG5661@1|root,COG5661@2|Bacteria,1PCP9@1224|Proteobacteria,1SW6Z@1236|Gammaproteobacteria,1XBB6@135614|Xanthomonadales	135614|Xanthomonadales	O	Bacterial protein of unknown function (DUF922)	-	-	-	-	-	-	-	-	-	-	-	-	DUF922
REGS1_k127_3590915_2	1122915.AUGY01000138_gene3189	1.759e-42	166.0	COG0095@1|root,COG0095@2|Bacteria,1TQ5U@1239|Firmicutes,4HABG@91061|Bacilli,26S5X@186822|Paenibacillaceae	91061|Bacilli	H	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation	lipM	GO:0003674,GO:0003824,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016415,GO:0016740,GO:0016746,GO:0016747,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
REGS1_k127_3599661_3	1232410.KI421414_gene2896	1.481e-16	79.0	COG1386@1|root,COG1386@2|Bacteria,1PUA6@1224|Proteobacteria,42SVD@68525|delta/epsilon subdivisions,2WPFX@28221|Deltaproteobacteria,43US2@69541|Desulfuromonadales	28221|Deltaproteobacteria	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves	scpB	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
REGS1_k127_3599661_0	289376.THEYE_A1300	4.588e-71	255.0	COG0791@1|root,COG1388@1|root,COG0791@2|Bacteria,COG1388@2|Bacteria	2|Bacteria	M	LysM domain	xynZ	-	3.5.1.28	ko:K01449,ko:K19223	-	-	R04112	RC00064,RC00141	ko00000,ko01000,ko01002,ko01011	-	CBM50	-	DUF823,DUF824,Esterase,LysM,NLPC_P60
REGS1_k127_3599661_1	926569.ANT_03380	5.989e-31	126.0	COG0239@1|root,COG0239@2|Bacteria,2G760@200795|Chloroflexi	200795|Chloroflexi	D	Important for reducing fluoride concentration in the cell, thus reducing its toxicity	crcB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425	-	ko:K06199	-	-	-	-	ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3	-	-	CRCB
REGS1_k127_3599661_2	309801.trd_1378	4.893e-22	99.0	COG1993@1|root,COG1993@2|Bacteria	2|Bacteria	T	acr, cog1993	-	-	-	ko:K09137	-	-	-	-	ko00000	-	-	-	CBS,DUF190
REGS1_k127_3625665_3	909663.KI867150_gene1421	7.715e-14	75.0	COG1651@1|root,COG1651@2|Bacteria,1NZDM@1224|Proteobacteria,430XZ@68525|delta/epsilon subdivisions,2WVMU@28221|Deltaproteobacteria,2MRVZ@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	Thioredoxin	-	-	-	ko:K03673	ko01503,map01503	M00728	-	-	ko00000,ko00001,ko00002,ko03110	-	-	-	Thioredoxin_4
REGS1_k127_3625665_1	713586.KB900536_gene2038	5.179e-55	203.0	COG0589@1|root,COG0589@2|Bacteria,1NBKV@1224|Proteobacteria,1SHMY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Universal stress protein family	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE,Usp
REGS1_k127_3625665_0	1131462.DCF50_p1172	3.741e-215	679.0	COG1032@1|root,COG1032@2|Bacteria,1UYAF@1239|Firmicutes,24D1D@186801|Clostridia,2612Q@186807|Peptococcaceae	186801|Clostridia	C	PFAM Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4070,Radical_SAM
REGS1_k127_3625665_2	589865.DaAHT2_1598	3.023e-45	170.0	2C5Z2@1|root,32U5Z@2|Bacteria,1N4MT@1224|Proteobacteria,42TX0@68525|delta/epsilon subdivisions,2WQZM@28221|Deltaproteobacteria,2MKYF@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF3786)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3786
REGS1_k127_369584_2	264462.Bd1403	5.504e-17	82.0	COG3324@1|root,COG3324@2|Bacteria,1N7Q5@1224|Proteobacteria,42Y00@68525|delta/epsilon subdivisions,2WT7X@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Glyoxalase-like domain	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	Glyoxalase
REGS1_k127_369584_0	796606.BMMGA3_06895	9.747e-119	405.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,4HBR0@91061|Bacilli,1ZQ9D@1386|Bacillus	91061|Bacilli	C	NADH:flavin oxidoreductase / NADH oxidase family	-	-	1.3.1.34	ko:K00219	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_FMN,Pyr_redox_2
REGS1_k127_369584_3	237368.SCABRO_00761	8.417e-11	63.0	COG1487@1|root,COG1487@2|Bacteria	2|Bacteria	S	nuclease activity	vapC	-	-	-	-	-	-	-	-	-	-	-	PIN
REGS1_k127_369584_1	1187851.A33M_3441	1.971e-37	142.0	COG0538@1|root,COG0538@2|Bacteria,1MUIB@1224|Proteobacteria,2TQWD@28211|Alphaproteobacteria,3FCUC@34008|Rhodovulum	28211|Alphaproteobacteria	C	Isocitrate/isopropylmalate dehydrogenase	icd	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
REGS1_k127_3741208_0	118173.KB235914_gene1738	4.482e-141	455.0	COG1899@1|root,COG1899@2|Bacteria,1G448@1117|Cyanobacteria,1H6YM@1150|Oscillatoriales	1117|Cyanobacteria	O	Belongs to the deoxyhypusine synthase family	-	-	2.5.1.46	ko:K00809	-	-	-	-	ko00000,ko01000	-	-	-	DS
REGS1_k127_3741208_3	593750.Metfor_1459	3.731e-84	282.0	COG1945@1|root,arCOG04490@2157|Archaea,2XX0H@28890|Euryarchaeota,2N9J2@224756|Methanomicrobia	224756|Methanomicrobia	E	Belongs to the PdaD family	pdaD	-	4.1.1.19	ko:K02626	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PvlArgDC
REGS1_k127_3741208_2	1121931.AUHG01000010_gene642	2.389e-88	305.0	COG0010@1|root,COG0010@2|Bacteria,4NE01@976|Bacteroidetes,1HYIB@117743|Flavobacteriia	976|Bacteroidetes	E	Belongs to the arginase family	speB	-	3.5.3.11	ko:K01480	ko00330,ko01100,map00330,map01100	M00133	R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
REGS1_k127_3741208_5	289376.THEYE_A0442	1.67e-14	75.0	COG2104@1|root,COG2104@2|Bacteria	2|Bacteria	H	thiamine diphosphate biosynthetic process	thiS	-	-	ko:K03154	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
REGS1_k127_3741208_1	289376.THEYE_A0443	4.525e-137	438.0	COG2022@1|root,COG2022@2|Bacteria,3J0EI@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S	thiG	-	2.8.1.10	ko:K03149	ko00730,ko01100,map00730,map01100	-	R10247	RC03096,RC03097,RC03461	ko00000,ko00001,ko01000	-	-	-	ThiG
REGS1_k127_3741208_4	289376.THEYE_A0444	1.951e-18	87.0	COG0352@1|root,COG0352@2|Bacteria,3J0QS@40117|Nitrospirae	40117|Nitrospirae	H	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)	thiE2	-	2.5.1.3	ko:K00788	ko00730,ko01100,map00730,map01100	M00127	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	TMP-TENI
REGS1_k127_3781141_4	1123376.AUIU01000016_gene215	3.239e-102	340.0	COG0275@1|root,COG0275@2|Bacteria,3J0NU@40117|Nitrospirae	40117|Nitrospirae	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	mraW	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
REGS1_k127_3781141_0	289376.THEYE_A1329	5.78e-191	612.0	COG0768@1|root,COG0768@2|Bacteria,3J0FH@40117|Nitrospirae	40117|Nitrospirae	M	Penicillin-binding Protein dimerisation domain	-	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PBP_dimer,Transpeptidase
REGS1_k127_3781141_2	289376.THEYE_A1328	1.829e-135	447.0	COG0769@1|root,COG0769@2|Bacteria,3J0DS@40117|Nitrospirae	40117|Nitrospirae	M	acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
REGS1_k127_3781141_3	289376.THEYE_A1327	3.198e-107	362.0	COG0770@1|root,COG0770@2|Bacteria,3J0PW@40117|Nitrospirae	40117|Nitrospirae	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
REGS1_k127_3781141_1	289376.THEYE_A1326	1.209e-162	521.0	COG0472@1|root,COG0472@2|Bacteria,3J0C4@40117|Nitrospirae	40117|Nitrospirae	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
REGS1_k127_3781141_5	289376.THEYE_A1325	9.364e-72	257.0	COG1686@1|root,COG1686@2|Bacteria,3J179@40117|Nitrospirae	40117|Nitrospirae	M	Belongs to the peptidase S11 family	-	-	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	Peptidase_S11
REGS1_k127_3781141_6	404589.Anae109_3882	6.689e-48	180.0	COG0771@1|root,COG0771@2|Bacteria,1MVYD@1224|Proteobacteria,42MJY@68525|delta/epsilon subdivisions,2WJAQ@28221|Deltaproteobacteria,2YU89@29|Myxococcales	28221|Deltaproteobacteria	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	AlaDh_PNT_C,FAD_binding_3,Mur_ligase_C,Mur_ligase_M,NAD_binding_8
REGS1_k127_3783606_1	62928.azo1401	7.062e-77	262.0	COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,2VJJ1@28216|Betaproteobacteria,2KUZS@206389|Rhodocyclales	206389|Rhodocyclales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	nuoF	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
REGS1_k127_3783606_0	330214.NIDE0609	1.211e-102	345.0	COG3383@1|root,COG3383@2|Bacteria,3J0UR@40117|Nitrospirae	40117|Nitrospirae	C	Molydopterin dinucleotide binding domain	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdopterin,Molydop_binding
REGS1_k127_3790466_4	439235.Dalk_4490	4.753e-75	263.0	COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,42M4Q@68525|delta/epsilon subdivisions,2X5DU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	iAF987.Gmet_0069	GGDEF,Response_reg
REGS1_k127_3790466_0	760568.Desku_2943	1.231e-242	766.0	COG0303@1|root,COG1910@1|root,COG0303@2|Bacteria,COG1910@2|Bacteria,1TRH3@1239|Firmicutes,24ATZ@186801|Clostridia,2612F@186807|Peptococcaceae	186801|Clostridia	HP	TIGRFAM molybdenum cofactor synthesis	-	-	2.10.1.1	ko:K03750,ko:K07219	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N,PBP_like
REGS1_k127_3790466_2	1121468.AUBR01000102_gene3096	2.609e-112	380.0	COG3894@1|root,COG3894@2|Bacteria,1TP0H@1239|Firmicutes,247S0@186801|Clostridia,42F3G@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
REGS1_k127_3790466_3	243231.GSU3312	4.066e-98	330.0	COG0276@1|root,COG0276@2|Bacteria,1MVR1@1224|Proteobacteria,42M0C@68525|delta/epsilon subdivisions,2WMJ2@28221|Deltaproteobacteria,43TS8@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes the ferrous insertion into protoporphyrin IX	hemH	GO:0003674,GO:0003824,GO:0004325,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	Ferrochelatase
REGS1_k127_3790466_1	289376.THEYE_A0719	3.258e-140	460.0	COG1232@1|root,COG1232@2|Bacteria,3J0PQ@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX	-	-	1.3.3.15,1.3.3.4	ko:K00231	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03222,R04178	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
REGS1_k127_3803417_2	289376.THEYE_A1953	1.452e-97	324.0	COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,3J0GG@40117|Nitrospirae	40117|Nitrospirae	M	Belongs to the SIS family. GutQ KpsF subfamily	-	-	5.3.1.13	ko:K06041	ko00540,ko01100,map00540,map01100	M00063	R01530	RC00541	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CBS,SIS
REGS1_k127_3803417_1	398767.Glov_2172	1.292e-112	371.0	COG2877@1|root,COG2877@2|Bacteria,1MV91@1224|Proteobacteria,42M61@68525|delta/epsilon subdivisions,2WIXU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	3-deoxy-D-manno-octulosonic acid 8-phosphate synthase	kdsA	-	2.5.1.55	ko:K01627	ko00540,ko01100,map00540,map01100	M00063	R03254	RC00435	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	DAHP_synth_1
REGS1_k127_3803417_0	335543.Sfum_2075	3.801e-247	774.0	COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,42MEU@68525|delta/epsilon subdivisions,2WJ0F@28221|Deltaproteobacteria,2MQ5R@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1276	CTP_synth_N,GATase
REGS1_k127_3803417_3	316067.Geob_2272	1.691e-70	247.0	COG1212@1|root,COG1212@2|Bacteria,1MUUU@1224|Proteobacteria,42PTX@68525|delta/epsilon subdivisions,2WMQW@28221|Deltaproteobacteria,43T2I@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria	kdsB	-	2.7.7.38	ko:K00979	ko00540,ko01100,map00540,map01100	M00063	R03351,R11396	RC00152,RC00910	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_3
REGS1_k127_3805724_1	46234.ANA_C11362	3.639e-142	458.0	COG0641@1|root,COG0641@2|Bacteria,1GAI2@1117|Cyanobacteria	1117|Cyanobacteria	C	Radical SAM additional 4Fe4S-binding domain	-	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SPASM
REGS1_k127_3805724_2	259536.Psyc_1587	0.0009522	42.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,3NIYQ@468|Moraxellaceae	1236|Gammaproteobacteria	P	P-type ATPase	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hydrolase,YHS
REGS1_k127_3805724_0	1304885.AUEY01000031_gene51	1.226e-260	814.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,42NCZ@68525|delta/epsilon subdivisions,2WK3X@28221|Deltaproteobacteria,2MI5E@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K07787	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4	-	iAF987.Gmet_1547	ACR_tran
REGS1_k127_3823661_8	289376.THEYE_A1677	1.193e-85	294.0	COG1127@1|root,COG1127@2|Bacteria,3J12B@40117|Nitrospirae	40117|Nitrospirae	Q	ABC transporter	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
REGS1_k127_3823661_6	289376.THEYE_A1676	4.3e-102	339.0	COG0767@1|root,COG0767@2|Bacteria,3J15A@40117|Nitrospirae	40117|Nitrospirae	Q	Permease MlaE	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
REGS1_k127_3823661_10	289376.THEYE_A1617	1.749e-17	89.0	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
REGS1_k127_3823661_9	1125863.JAFN01000001_gene1446	4.192e-23	102.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K02481	-	-	-	-	ko00000,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
REGS1_k127_3823661_0	1123376.AUIU01000013_gene1777	7.183e-202	647.0	COG2905@1|root,COG2905@2|Bacteria,3J0UW@40117|Nitrospirae	40117|Nitrospirae	T	Domain in cystathionine beta-synthase and other proteins.	-	-	-	ko:K07182	-	-	-	-	ko00000	-	-	-	CBS,DUF294,DUF294_C,cNMP_binding
REGS1_k127_3823661_4	716928.AJQT01000047_gene2152	2.193e-107	354.0	COG0395@1|root,COG0395@2|Bacteria,1N4I0@1224|Proteobacteria,2TT14@28211|Alphaproteobacteria,4B7QA@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	ABC transporter (Permease	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
REGS1_k127_3823661_7	716928.AJQT01000047_gene2151	3.939e-97	326.0	COG1175@1|root,COG1175@2|Bacteria,1MWB7@1224|Proteobacteria,2TUAN@28211|Alphaproteobacteria,4B76N@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	ABC transporter permease	MA20_03545	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
REGS1_k127_3823661_3	323097.Nham_1207	3.219e-121	397.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQQJ@28211|Alphaproteobacteria,3JQYC@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Part of the ABC transporter complex UgpABCE involved in sn-glycerol-3-phosphate import. Responsible for energy coupling to the transport system	-	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE_2
REGS1_k127_3823661_1	716928.AJQT01000047_gene2149	2.249e-181	578.0	COG1653@1|root,COG1653@2|Bacteria,1MU64@1224|Proteobacteria,2VFE8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
REGS1_k127_3823661_5	666681.M301_1219	4.384e-106	354.0	COG0628@1|root,COG0628@2|Bacteria,1MW34@1224|Proteobacteria,2VIKI@28216|Betaproteobacteria,2KM46@206350|Nitrosomonadales	206350|Nitrosomonadales	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
REGS1_k127_3823661_11	1121423.JONT01000006_gene2416	1.794e-11	66.0	COG1826@1|root,COG1826@2|Bacteria,1TV3X@1239|Firmicutes,259BA@186801|Clostridia,2639X@186807|Peptococcaceae	186801|Clostridia	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	tatA	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
REGS1_k127_3823661_2	309799.DICTH_0361	1.533e-167	535.0	COG1914@1|root,COG1914@2|Bacteria	2|Bacteria	P	metal ion transmembrane transporter activity	mntH	-	-	ko:K03322	-	-	-	-	ko00000,ko02000	2.A.55.2.6,2.A.55.3	-	-	Nramp
REGS1_k127_3925245_1	289376.THEYE_A0879	4.841e-91	305.0	COG1127@1|root,COG1127@2|Bacteria,3J0J2@40117|Nitrospirae	40117|Nitrospirae	Q	ABC transporter	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
REGS1_k127_3925245_0	1123376.AUIU01000014_gene686	6.531e-107	352.0	COG0767@1|root,COG0767@2|Bacteria,3J0I7@40117|Nitrospirae	40117|Nitrospirae	Q	Permease MlaE	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
REGS1_k127_3925245_2	690850.Desaf_1094	3.113e-37	146.0	COG3735@1|root,COG3735@2|Bacteria,1MVCW@1224|Proteobacteria,42T82@68525|delta/epsilon subdivisions,2WTPA@28221|Deltaproteobacteria,2MC89@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	TraB family	-	-	-	ko:K09973	-	-	-	-	ko00000	-	-	-	TraB
REGS1_k127_3934358_5	289376.THEYE_A0567	5.882e-37	141.0	COG1960@1|root,COG1960@2|Bacteria,3J13U@40117|Nitrospirae	40117|Nitrospirae	C	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
REGS1_k127_3934358_1	1459636.NTE_02180	3.892e-106	351.0	COG1830@1|root,arCOG04044@2157|Archaea,41S64@651137|Thaumarchaeota	651137|Thaumarchaeota	E	DeoC/LacD family aldolase	-	-	2.3.1.245	ko:K08321	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000	-	-	-	DeoC
REGS1_k127_3934358_0	247490.KSU1_C0515	2.273e-129	422.0	COG1063@1|root,COG1063@2|Bacteria,2J2DX@203682|Planctomycetes	203682|Planctomycetes	E	Alcohol dehydrogenase GroES-like domain	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
REGS1_k127_3934358_2	269799.Gmet_0947	4.95e-102	347.0	COG0312@1|root,COG0312@2|Bacteria,1MUVW@1224|Proteobacteria,42RID@68525|delta/epsilon subdivisions,2WN9N@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Peptidase U62 modulator of DNA gyrase	pmbA	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
REGS1_k127_3934358_4	289376.THEYE_A0569	1.113e-46	171.0	COG0720@1|root,COG0720@2|Bacteria,3J0TW@40117|Nitrospirae	40117|Nitrospirae	H	6-pyruvoyl tetrahydropterin synthase	-	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
REGS1_k127_3934358_3	289376.THEYE_A0570	2.068e-58	205.0	COG0634@1|root,COG0634@2|Bacteria,3J0NZ@40117|Nitrospirae	40117|Nitrospirae	F	Phosphoribosyl transferase domain	hpt	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
REGS1_k127_3942260_2	111780.Sta7437_1526	5.503e-30	124.0	COG2334@1|root,COG2334@2|Bacteria,1G3HF@1117|Cyanobacteria,3VJ46@52604|Pleurocapsales	1117|Cyanobacteria	S	homoserine kinase type II (Protein kinase fold)	-	-	-	-	-	-	-	-	-	-	-	-	APH
REGS1_k127_3942260_9	1232437.KL662056_gene5408	0.0001413	51.0	2CHB9@1|root,340BH@2|Bacteria,1NX7J@1224|Proteobacteria,430HF@68525|delta/epsilon subdivisions,2WVKT@28221|Deltaproteobacteria,2MNP8@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_3942260_0	316067.Geob_0942	4.405e-135	448.0	COG2133@1|root,COG2133@2|Bacteria,1MV2E@1224|Proteobacteria	1224|Proteobacteria	G	glucose sorbosone	gdhB	-	1.1.5.2	ko:K00117	ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130	-	R06620	RC00066	ko00000,ko00001,ko01000	-	-	-	CBM_2,GSDH
REGS1_k127_3942260_3	448385.sce6756	1.856e-28	126.0	2E0EH@1|root,2ZZNI@2|Bacteria,1Q8YZ@1224|Proteobacteria,438YN@68525|delta/epsilon subdivisions,2X441@28221|Deltaproteobacteria,2YY76@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_3942260_6	883078.HMPREF9695_04682	2.189e-15	87.0	2ADPM@1|root,313EP@2|Bacteria,1N6GG@1224|Proteobacteria,2UEKX@28211|Alphaproteobacteria,3K0FH@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Kazal type serine protease inhibitors	-	-	-	-	-	-	-	-	-	-	-	-	Kazal_1
REGS1_k127_3942260_5	211165.AJLN01000120_gene795	7.996e-20	94.0	COG0727@1|root,COG0727@2|Bacteria,1GFCE@1117|Cyanobacteria	1117|Cyanobacteria	S	Putative zinc- or iron-chelating domain	-	-	-	-	-	-	-	-	-	-	-	-	CxxCxxCC
REGS1_k127_3942260_1	1304885.AUEY01000009_gene1980	1.254e-110	365.0	COG2885@1|root,COG2885@2|Bacteria,1MWHF@1224|Proteobacteria	1224|Proteobacteria	M	Belongs to the ompA family	-	-	-	ko:K03286	-	-	-	-	ko00000,ko02000	1.B.6	-	-	BON,OMP_b-brl,OmpA
REGS1_k127_3942260_4	744872.Spica_0425	3.499e-27	112.0	COG2026@1|root,COG2026@2|Bacteria,2J95Y@203691|Spirochaetes	203691|Spirochaetes	DJ	Addiction module toxin, RelE StbE family	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_3942260_8	1123073.KB899242_gene1309	2.678e-05	49.0	293J8@1|root,2ZR19@2|Bacteria,1R6Y4@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_3942260_10	1123371.ATXH01000006_gene834	0.000148	51.0	COG3215@1|root,COG3215@2|Bacteria,2GIKF@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	NU	PilZ domain	-	-	-	ko:K02676	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilZ
REGS1_k127_3946139_1	289376.THEYE_A0828	1.169e-115	379.0	COG0399@1|root,COG0399@2|Bacteria,3J09X@40117|Nitrospirae	40117|Nitrospirae	E	Belongs to the DegT DnrJ EryC1 family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
REGS1_k127_3946139_2	1047013.AQSP01000085_gene1995	1.038e-78	273.0	COG0673@1|root,COG0673@2|Bacteria,2NNUQ@2323|unclassified Bacteria	2|Bacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	gnnA	-	-	ko:K09949	-	-	-	-	ko00000	-	-	iAF987.Gmet_2352	GFO_IDH_MocA
REGS1_k127_3946139_0	289376.THEYE_A0539	6.617e-140	452.0	COG0232@1|root,COG0232@2|Bacteria	2|Bacteria	F	Belongs to the dGTPase family. Type 2 subfamily	dgt	GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008832,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009151,GO:0009155,GO:0009166,GO:0009200,GO:0009204,GO:0009215,GO:0009217,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016787,GO:0016788,GO:0016793,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042578,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046070,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	-	HD,HD_assoc
REGS1_k127_3946139_3	338963.Pcar_0398	4.195e-32	129.0	arCOG05277@1|root,336C4@2|Bacteria,1NZZE@1224|Proteobacteria,43162@68525|delta/epsilon subdivisions,2WWEH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_3946139_5	1123073.KB899241_gene1946	0.0008399	49.0	COG0457@1|root,COG0457@2|Bacteria,1MVMG@1224|Proteobacteria,1RU5N@1236|Gammaproteobacteria,1X4BW@135614|Xanthomonadales	135614|Xanthomonadales	S	Sulfotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3,TPR_16
REGS1_k127_3946139_4	448385.sce2419	2.424e-09	66.0	COG0484@1|root,COG0484@2|Bacteria,1R0C7@1224|Proteobacteria,43CUM@68525|delta/epsilon subdivisions,2X82A@28221|Deltaproteobacteria,2Z3JM@29|Myxococcales	28221|Deltaproteobacteria	O	DnaJ molecular chaperone homology domain	-	-	-	-	-	-	-	-	-	-	-	-	DnaJ
REGS1_k127_3947972_4	395494.Galf_2614	4.04e-38	147.0	COG2193@1|root,COG2193@2|Bacteria	2|Bacteria	P	ferroxidase activity	bfr	GO:0006873,GO:0006875,GO:0006879,GO:0006880,GO:0008150,GO:0009987,GO:0019725,GO:0030003,GO:0042592,GO:0046916,GO:0048878,GO:0050801,GO:0051179,GO:0051235,GO:0051238,GO:0051641,GO:0051651,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0097577,GO:0098771	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
REGS1_k127_3947972_3	589865.DaAHT2_1612	1.1e-45	179.0	COG2897@1|root,COG2897@2|Bacteria,1MW4B@1224|Proteobacteria,42P9A@68525|delta/epsilon subdivisions,2WIW1@28221|Deltaproteobacteria,2MKQR@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Rhodanese Homology Domain	-	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
REGS1_k127_3947972_7	1254432.SCE1572_13065	1.283e-11	68.0	2CE3X@1|root,33E3Z@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_3947972_1	485916.Dtox_0124	8.931e-100	332.0	COG0491@1|root,COG0491@2|Bacteria,1V2XF@1239|Firmicutes,24JW4@186801|Clostridia	186801|Clostridia	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
REGS1_k127_3947972_5	497964.CfE428DRAFT_3727	1.966e-22	103.0	2FH6M@1|root,34912@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4203)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4203
REGS1_k127_3947972_0	1232410.KI421412_gene312	3.834e-188	608.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,42MKU@68525|delta/epsilon subdivisions,2WJR3@28221|Deltaproteobacteria,43RY9@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	UvrD-like helicase C-terminal domain	rep	-	3.6.4.12	ko:K03656,ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
REGS1_k127_3947972_2	404380.Gbem_0269	3.98e-83	284.0	COG1276@1|root,COG4892@1|root,COG1276@2|Bacteria,COG4892@2|Bacteria	2|Bacteria	S	Cytochrome b5-like Heme/Steroid binding domain	copC	-	-	ko:K07245,ko:K14166	-	-	-	-	ko00000,ko02000	9.B.62.1	-	-	CopC,CopD,Cyt-b5,Cytochrome_CBB3
REGS1_k127_3959445_0	909663.KI867150_gene1700	4.944e-91	303.0	COG2038@1|root,COG2038@2|Bacteria,1MVAM@1224|Proteobacteria,42M3Z@68525|delta/epsilon subdivisions,2WJIR@28221|Deltaproteobacteria,2MQA3@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB)	cobT	GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008939,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0017144,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042364,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.4.2.21	ko:K00768	ko00860,ko01100,map00860,map01100	M00122	R04148	RC00033,RC00063	ko00000,ko00001,ko00002,ko01000	-	-	-	DBI_PRT
REGS1_k127_3959445_3	161156.JQKW01000008_gene563	5.922e-46	177.0	COG0368@1|root,COG0368@2|Bacteria,2GI54@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	H	Cobalamin-5-phosphate synthase	-	-	2.7.8.26	ko:K02233	ko00860,ko01100,map00860,map01100	M00122	R05223,R11174	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CobS
REGS1_k127_3959445_1	589865.DaAHT2_1519	4.682e-68	241.0	COG0406@1|root,COG0406@2|Bacteria,1RHAT@1224|Proteobacteria,42SUD@68525|delta/epsilon subdivisions,2WP5H@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	PFAM Phosphoglycerate mutase	cobC	-	3.1.3.73	ko:K02226	ko00860,ko01100,map00860,map01100	M00122	R04594,R11173	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
REGS1_k127_3959445_2	555779.Dthio_PD2848	1.998e-61	229.0	COG4206@1|root,COG4206@2|Bacteria,1QTTF@1224|Proteobacteria,43D2X@68525|delta/epsilon subdivisions,2X8A2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	PFAM TonB-dependent Receptor Plug	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug
REGS1_k127_3972019_0	909663.KI867150_gene1244	2.578e-169	537.0	COG2070@1|root,COG2070@2|Bacteria,1N52W@1224|Proteobacteria,42N6F@68525|delta/epsilon subdivisions,2WKX7@28221|Deltaproteobacteria,2MQUQ@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Nitronate monooxygenase	-	-	1.13.12.16	ko:K00459	ko00910,map00910	-	R00025	RC02541,RC02759	ko00000,ko00001,ko01000	-	-	-	NMO
REGS1_k127_3972019_6	638303.Thal_0112	2.654e-19	89.0	COG0425@1|root,COG0425@2|Bacteria,2G5AY@200783|Aquificae	200783|Aquificae	O	Belongs to the sulfur carrier protein TusA family	-	-	-	-	-	-	-	-	-	-	-	-	TusA
REGS1_k127_3972019_4	237368.SCABRO_00962	9.74e-112	366.0	COG0476@1|root,COG0476@2|Bacteria,2IY5K@203682|Planctomycetes	203682|Planctomycetes	H	ThiF family	-	-	-	-	-	-	-	-	-	-	-	-	ThiF
REGS1_k127_3972019_5	644966.Tmar_1104	1.066e-27	116.0	COG1310@1|root,COG1310@2|Bacteria,1V6TY@1239|Firmicutes,24JI8@186801|Clostridia	186801|Clostridia	S	Mov34 MPN PAD-1 family	-	-	3.13.1.6	ko:K21140	ko04122,map04122	-	R11524	RC00064,RC00090	ko00000,ko00001,ko01000	-	-	-	Prok-JAB
REGS1_k127_3972019_3	1123376.AUIU01000014_gene728	2.76e-113	372.0	COG0501@1|root,COG0501@2|Bacteria,3J0QG@40117|Nitrospirae	40117|Nitrospirae	O	Peptidase family M48	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
REGS1_k127_3972019_2	247490.KSU1_B0189	9.26e-130	425.0	COG3424@1|root,COG3424@2|Bacteria,2IYDA@203682|Planctomycetes	203682|Planctomycetes	Q	Chalcone and stilbene synthases, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Chal_sti_synt_C,Chal_sti_synt_N
REGS1_k127_3972019_1	247490.KSU1_B0190	2.169e-167	537.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
REGS1_k127_3978036_0	323848.Nmul_A0355	3.095e-98	331.0	COG0446@1|root,COG0446@2|Bacteria,1NR3M@1224|Proteobacteria,2VJSV@28216|Betaproteobacteria,372DS@32003|Nitrosomonadales	28216|Betaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	camA	-	1.18.1.3	ko:K00529,ko:K18227,ko:K18249	ko00071,ko00360,ko00622,ko00627,ko01120,ko01220,map00071,map00360,map00622,map00627,map01120,map01220	M00539,M00545,M00637	R00823,R00825,R02000,R05247,R06782,R06783	RC00098,RC00192,RC00267	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	Pyr_redox_2,Reductase_C
REGS1_k127_3978036_6	1122201.AUAZ01000033_gene3220	1.903e-24	107.0	COG2154@1|root,COG2154@2|Bacteria,1RH99@1224|Proteobacteria,1S5YX@1236|Gammaproteobacteria,467XF@72275|Alteromonadaceae	1236|Gammaproteobacteria	H	pterin-4-alpha-carbinolamine dehydratase	phhB	-	4.2.1.96	ko:K01724	ko00790,map00790	-	R04734	RC01208	ko00000,ko00001,ko01000,ko04147	-	-	-	Pterin_4a
REGS1_k127_3978036_9	1394178.AWOO02000025_gene4979	9.366e-07	52.0	COG1028@1|root,COG1028@2|Bacteria	1394178.AWOO02000025_gene4979|-	IQ	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_3978036_5	156889.Mmc1_0329	4.653e-27	113.0	COG1539@1|root,COG1539@2|Bacteria	2|Bacteria	H	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin	folX	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0008719,GO:0009987,GO:0016853,GO:0019752,GO:0034641,GO:0042558,GO:0043436,GO:0043603,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0071704,GO:1901360,GO:1901564	1.13.11.81,4.1.2.25,5.1.99.7,5.1.99.8	ko:K01633,ko:K07589	ko00790,ko01100,map00790,map01100	M00126,M00840	R03504,R11037,R11073,R11082	RC00721,RC00943,RC01479,RC03333,RC03334	ko00000,ko00001,ko00002,ko01000	-	-	-	FolB
REGS1_k127_3978036_4	397948.Cmaq_0517	4.963e-43	164.0	COG0801@1|root,arCOG07203@2157|Archaea	2157|Archaea	H	Dihydroneopterin aldolase	-	-	-	-	-	-	-	-	-	-	-	-	FolB,HPPK
REGS1_k127_3978036_3	1499967.BAYZ01000145_gene6204	1.357e-71	246.0	COG0302@1|root,COG0302@2|Bacteria,2NPAT@2323|unclassified Bacteria	2|Bacteria	H	GTP cyclohydrolase I	folE	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydroI
REGS1_k127_3978036_7	289376.THEYE_A1382	1.975e-22	110.0	COG0860@1|root,COG0860@2|Bacteria	2|Bacteria	M	N-Acetylmuramoyl-L-alanine amidase	-	-	3.5.1.28	ko:K01448,ko:K02172	ko01501,ko01503,map01501,map01503	M00627,M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504,ko03036	-	-	-	Amidase_3,Cu_amine_oxidN1,Glucosaminidase,PG_binding_1,Peptidase_M56,Y_Y_Y
REGS1_k127_3978036_8	439235.Dalk_3055	4.177e-15	83.0	COG5401@1|root,COG5401@2|Bacteria,1NA0G@1224|Proteobacteria,42V1V@68525|delta/epsilon subdivisions,2WRCV@28221|Deltaproteobacteria,2MKUK@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Sporulation and spore germination	-	-	-	-	-	-	-	-	-	-	-	-	Germane
REGS1_k127_3978036_2	443143.GM18_0312	9.387e-91	306.0	COG0796@1|root,COG0796@2|Bacteria,1NAI2@1224|Proteobacteria,42P58@68525|delta/epsilon subdivisions,2WKYK@28221|Deltaproteobacteria,43TAQ@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Provides the (R)-glutamate required for cell wall biosynthesis	murI	-	5.1.1.3	ko:K01776	ko00471,ko01100,map00471,map01100	-	R00260	RC00302	ko00000,ko00001,ko01000,ko01011	-	-	iAF987.Gmet_0547	Asp_Glu_race
REGS1_k127_3978036_1	289376.THEYE_A1385	2.051e-95	317.0	COG0689@1|root,COG0689@2|Bacteria,3J0B8@40117|Nitrospirae	40117|Nitrospirae	J	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates	rph	GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575	2.7.7.56	ko:K00989	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNase_PH,RNase_PH_C
REGS1_k127_4001827_1	102125.Xen7305DRAFT_00018640	2.882e-114	382.0	COG1134@1|root,COG1134@2|Bacteria,1G28R@1117|Cyanobacteria,3VIKU@52604|Pleurocapsales	1117|Cyanobacteria	GM	ABC-type polysaccharide polyol phosphate transport system ATPase component	-	-	-	ko:K09691	ko02010,map02010	M00250	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.103	-	-	ABC_tran,Wzt_C
REGS1_k127_4001827_3	1346330.M472_19230	1.103e-40	153.0	COG0399@1|root,COG0399@2|Bacteria,4PKRF@976|Bacteroidetes,1IU6R@117747|Sphingobacteriia	976|Bacteroidetes	J	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
REGS1_k127_4001827_2	237368.SCABRO_01358	4.38e-106	352.0	COG1682@1|root,COG1682@2|Bacteria,2IYXC@203682|Planctomycetes	203682|Planctomycetes	U	COG1682 ABC-type polysaccharide polyol phosphate export systems, permease component	-	-	-	ko:K09690	ko02010,map02010	M00250	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.103	-	-	ABC2_membrane
REGS1_k127_4001827_0	289376.THEYE_A0472	1.839e-173	547.0	COG0451@1|root,COG0451@2|Bacteria,3J0BW@40117|Nitrospirae	40117|Nitrospirae	M	3-beta hydroxysteroid dehydrogenase/isomerase family	-	-	4.1.1.35,4.2.1.46	ko:K01710,ko:K08678	ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00520,map00521,map00523,map00525,map01055,map01100,map01130	M00361,M00793	R01384,R06513	RC00402,RC00508	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
REGS1_k127_4001827_5	1047013.AQSP01000144_gene777	1.13e-27	116.0	COG1846@1|root,COG1846@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	ko:K18996	-	-	-	-	ko00000,ko03032	-	-	-	HTH_24
REGS1_k127_4001827_4	768670.Calni_0452	2.55e-34	137.0	COG0250@1|root,COG0250@2|Bacteria,2GGK9@200930|Deferribacteres	200930|Deferribacteres	K	KOW (Kyprides, Ouzounis, Woese) motif.	-	-	-	ko:K05785	-	-	-	-	ko00000,ko03000	-	-	-	NusG
REGS1_k127_4001827_6	1287116.X734_00295	2.78e-24	108.0	COG4464@1|root,COG4464@2|Bacteria,1R5E2@1224|Proteobacteria,2U3T5@28211|Alphaproteobacteria,43NA7@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	GM	PFAM PHP domain protein	-	-	3.1.3.48	ko:K01104	-	-	-	-	ko00000,ko01000	-	-	-	-
REGS1_k127_4003341_0	338966.Ppro_0559	1.491e-53	194.0	COG2853@1|root,COG2853@2|Bacteria,1MVX0@1224|Proteobacteria,42RII@68525|delta/epsilon subdivisions,2WNS9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	PFAM VacJ family lipoprotein	-	-	-	ko:K04754	-	-	-	-	ko00000	-	-	-	MlaA
REGS1_k127_4003341_1	289376.THEYE_A0882	4.447e-53	193.0	COG2854@1|root,COG2854@2|Bacteria,3J13Z@40117|Nitrospirae	40117|Nitrospirae	Q	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K07323	ko02010,map02010	M00210	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27.3	-	-	MlaC
REGS1_k127_4003341_2	289376.THEYE_A0880	5.397e-46	170.0	COG1463@1|root,COG1463@2|Bacteria,3J191@40117|Nitrospirae	40117|Nitrospirae	Q	MlaD protein	-	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
REGS1_k127_4015793_0	289376.THEYE_A0536	1.059e-311	977.0	COG0013@1|root,COG0013@2|Bacteria,3J0D3@40117|Nitrospirae	40117|Nitrospirae	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
REGS1_k127_4015793_3	634956.Geoth_2092	3.706e-07	56.0	COG3937@1|root,COG3937@2|Bacteria,1VF6E@1239|Firmicutes,4HQ9W@91061|Bacilli,1WGPY@129337|Geobacillus	91061|Bacilli	S	ATP synthase, subunit b	-	-	-	-	-	-	-	-	-	-	-	-	Phasin
REGS1_k127_4015793_1	1123376.AUIU01000012_gene1420	4.37e-181	582.0	COG0661@1|root,COG0661@2|Bacteria,3J0ZH@40117|Nitrospirae	40117|Nitrospirae	S	ABC1 family	-	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1,APH
REGS1_k127_4015793_2	1125863.JAFN01000001_gene3400	2.116e-18	93.0	COG2201@1|root,COG2201@2|Bacteria	2|Bacteria	NT	protein-glutamate methylesterase activity	-	-	2.1.1.80,3.1.1.61,3.5.1.44	ko:K00575,ko:K03412,ko:K03413,ko:K07719	ko02020,ko02030,map02020,map02030	M00506,M00518	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,CheR,CheR_N,HATPase_c,HisKA,Response_reg
REGS1_k127_4049294_0	243231.GSU0319	7.085e-24	111.0	2DRH1@1|root,33BQ8@2|Bacteria	2|Bacteria	-	-	gspN	-	-	-	-	-	-	-	-	-	-	-	AsmA_2
REGS1_k127_4049294_1	1123376.AUIU01000016_gene307	1.66e-15	83.0	COG1734@1|root,COG1734@2|Bacteria,3J0R1@40117|Nitrospirae	40117|Nitrospirae	T	Prokaryotic dksA/traR C4-type zinc finger	-	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
REGS1_k127_4051021_2	289376.THEYE_A1235	1.294e-28	119.0	COG0789@1|root,COG0789@2|Bacteria,3J0VF@40117|Nitrospirae	40117|Nitrospirae	K	helix_turn_helix, mercury resistance	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
REGS1_k127_4051021_3	404589.Anae109_1886	8.018e-27	112.0	COG0776@1|root,COG0776@2|Bacteria,1RH5Z@1224|Proteobacteria,42TK0@68525|delta/epsilon subdivisions,2WQ5D@28221|Deltaproteobacteria,2YVCZ@29|Myxococcales	28221|Deltaproteobacteria	K	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control	himA	-	-	ko:K04764	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
REGS1_k127_4051021_0	1089553.Tph_c15450	4.329e-215	677.0	COG0043@1|root,COG0043@2|Bacteria,1TQ6V@1239|Firmicutes,248WY@186801|Clostridia,42F6I@68295|Thermoanaerobacterales	186801|Clostridia	H	Belongs to the UbiD family	-	-	4.1.1.61,4.1.1.98	ko:K03182,ko:K16239	ko00130,ko00627,ko01100,ko01110,ko01120,map00130,map00627,map01100,map01110,map01120	M00117	R01238,R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
REGS1_k127_4051021_4	765420.OSCT_2916	1.823e-26	113.0	COG1950@1|root,COG1950@2|Bacteria,2G7E6@200795|Chloroflexi,375XQ@32061|Chloroflexia	32061|Chloroflexia	S	PFAM membrane protein of	-	-	-	ko:K08972	-	-	-	-	ko00000	-	-	-	Phage_holin_4_2
REGS1_k127_4051021_1	370438.PTH_2596	2.264e-127	413.0	COG0031@1|root,COG0031@2|Bacteria,1TRM4@1239|Firmicutes,25BF7@186801|Clostridia,260E0@186807|Peptococcaceae	186801|Clostridia	E	TIGRFAM cysteine	-	-	2.5.1.47	ko:K12339	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03132,R03601,R04859	RC00020,RC02814,RC02821,RC02876	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
REGS1_k127_4051021_5	443143.GM18_3774	2.361e-10	63.0	COG4980@1|root,COG4980@2|Bacteria	2|Bacteria	D	gas vesicle protein	XK27_07760	-	-	-	-	-	-	-	-	-	-	-	YtxH
REGS1_k127_4056030_0	1123376.AUIU01000012_gene1403	1.521e-93	313.0	COG1995@1|root,COG1995@2|Bacteria,3J0GF@40117|Nitrospirae	40117|Nitrospirae	C	Pyridoxal phosphate biosynthetic protein PdxA	pdxA	-	1.1.1.262,1.1.1.408,1.1.1.409	ko:K00097,ko:K22024	ko00750,ko01100,map00750,map01100	M00124	R05681,R05837,R07406	RC00089,RC00675,RC01475	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxA
REGS1_k127_4056030_1	926561.KB900617_gene2281	8.638e-59	210.0	COG0030@1|root,COG0030@2|Bacteria,1TP9W@1239|Firmicutes,248RY@186801|Clostridia,3WAFX@53433|Halanaerobiales	186801|Clostridia	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
REGS1_k127_4114440_1	933262.AXAM01000017_gene3113	4.241e-184	595.0	COG4206@1|root,COG4206@2|Bacteria,1MW63@1224|Proteobacteria,42PQU@68525|delta/epsilon subdivisions,2WM3U@28221|Deltaproteobacteria,2MMU8@213118|Desulfobacterales	28221|Deltaproteobacteria	H	TonB dependent receptor	-	-	-	ko:K16092	-	-	-	-	ko00000,ko02000	1.B.14.3	-	-	Plug,TonB_dep_Rec
REGS1_k127_4114440_3	243231.GSU1891	8.693e-128	418.0	COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,42QB7@68525|delta/epsilon subdivisions,2WM6Y@28221|Deltaproteobacteria,43UAJ@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	HD domain	-	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	HD,Response_reg
REGS1_k127_4114440_0	1123392.AQWL01000001_gene1526	2.457e-189	596.0	COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,2VH2N@28216|Betaproteobacteria,1KS2R@119069|Hydrogenophilales	119069|Hydrogenophilales	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
REGS1_k127_4114440_2	289376.THEYE_A0113	7.177e-166	529.0	COG0136@1|root,COG0136@2|Bacteria,3J0BR@40117|Nitrospirae	40117|Nitrospirae	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
REGS1_k127_4114440_4	289376.THEYE_A1213	5.27e-37	143.0	COG0402@1|root,COG0402@2|Bacteria	2|Bacteria	F	S-adenosylhomocysteine deaminase activity	mtaD	-	3.5.4.28,3.5.4.31	ko:K12960	ko00270,ko01100,map00270,map01100	-	R09660	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
REGS1_k127_4119825_4	574087.Acear_2162	1.068e-10	71.0	2C678@1|root,32X5N@2|Bacteria	2|Bacteria	S	PFAM Sulfotransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_1,Sulfotransfer_3
REGS1_k127_4119825_3	1224746.B932_3723	7.622e-11	71.0	COG3012@1|root,COG3012@2|Bacteria,1NV40@1224|Proteobacteria,2U21K@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	SEC-C Motif Domain Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_4119825_2	1121403.AUCV01000078_gene4202	2.371e-18	86.0	COG1141@1|root,COG1141@2|Bacteria,1NFMM@1224|Proteobacteria,42WKK@68525|delta/epsilon subdivisions,2WRFD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Divergent 4Fe-4S mono-cluster	-	-	-	ko:K05337	-	-	-	-	ko00000	-	-	-	Fer4_13
REGS1_k127_4119825_0	289376.THEYE_A0971	1.049e-112	373.0	COG0079@1|root,COG0079@2|Bacteria,3J11B@40117|Nitrospirae	40117|Nitrospirae	E	Aminotransferase class I and II	-	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
REGS1_k127_4119825_1	269799.Gmet_0386	1.086e-72	250.0	COG0131@1|root,COG0131@2|Bacteria,1MWBS@1224|Proteobacteria,42NIV@68525|delta/epsilon subdivisions,2WNA4@28221|Deltaproteobacteria,43SWF@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	imidazoleglycerol-phosphate dehydratase activity	hisB	GO:0000105,GO:0003674,GO:0003824,GO:0004424,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.1.19	ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03457	RC00932	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPD
REGS1_k127_4173358_1	1047013.AQSP01000135_gene1559	2.78e-47	183.0	COG0860@1|root,COG0860@2|Bacteria,2NPCZ@2323|unclassified Bacteria	2|Bacteria	M	Ami_3	amiC	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	AMIN,Amidase_3,TPR_6
REGS1_k127_4173358_0	1142394.PSMK_08370	6.604e-95	321.0	COG1077@1|root,COG1077@2|Bacteria	2|Bacteria	D	Cell shape determining protein MreB Mrl	mreB2	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
REGS1_k127_4186502_0	289376.THEYE_A1884	1.861e-294	921.0	COG0532@1|root,COG0532@2|Bacteria,3J0CC@40117|Nitrospirae	40117|Nitrospirae	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
REGS1_k127_4186502_2	289376.THEYE_A1885	2.824e-39	149.0	COG0858@1|root,COG0858@2|Bacteria,3J0VV@40117|Nitrospirae	40117|Nitrospirae	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
REGS1_k127_4186502_1	1123376.AUIU01000011_gene954	6.731e-70	248.0	COG0618@1|root,COG0618@2|Bacteria	2|Bacteria	S	phosphoesterase RecJ domain protein	nrnA	GO:0008150,GO:0040007	3.1.13.3,3.1.3.7	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
REGS1_k127_4186502_3	232346.JHQL01000005_gene3153	3.88e-31	125.0	COG0130@1|root,COG0130@2|Bacteria,1MV0N@1224|Proteobacteria,1RMKP@1236|Gammaproteobacteria,1XH40@135619|Oceanospirillales	135619|Oceanospirillales	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	-	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB-C_2,TruB_C_2,TruB_N
REGS1_k127_4216959_2	926562.Oweho_1507	5.563e-45	173.0	COG0500@1|root,COG2226@2|Bacteria,4NEDR@976|Bacteroidetes,1HX52@117743|Flavobacteriia,2PA5X@246874|Cryomorphaceae	976|Bacteroidetes	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)	menG	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
REGS1_k127_4216959_1	1123376.AUIU01000015_gene362	7.59e-81	276.0	COG3842@1|root,COG3842@2|Bacteria	2|Bacteria	P	ATPase activity	gtsA	-	3.6.3.30,3.6.3.55	ko:K02010,ko:K02049,ko:K02068,ko:K02071,ko:K06857,ko:K10112	ko02010,map02010	M00186,M00188,M00190,M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00211,M00238,M00491,M00602,M00605,M00606	R10531	RC00002	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.1,3.A.1.10,3.A.1.16,3.A.1.17,3.A.1.24,3.A.1.6.2,3.A.1.6.4	-	-	ABC_tran,TOBE_2
REGS1_k127_4216959_0	289376.THEYE_A0048	1.259e-82	279.0	COG4662@1|root,COG4662@2|Bacteria,3J12J@40117|Nitrospirae	40117|Nitrospirae	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K05773	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	BPD_transp_1
REGS1_k127_4217933_3	373903.Hore_21140	2.848e-05	49.0	COG0760@1|root,COG0760@2|Bacteria,1TX3R@1239|Firmicutes,25C37@186801|Clostridia,3WAP3@53433|Halanaerobiales	186801|Clostridia	M	PPIC-type PPIASE domain	-	-	5.2.1.8	ko:K03769,ko:K07533	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Cu_amine_oxidN1,Rotamase_2,Rotamase_3,SurA_N_3
REGS1_k127_4217933_2	1121920.AUAU01000030_gene2713	1.279e-12	74.0	2E6X5@1|root,331GM@2|Bacteria,3Y5N8@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_4217933_0	289376.THEYE_A1671	1.078e-99	330.0	COG0854@1|root,COG0854@2|Bacteria,3J0KZ@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate	pdxJ	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	2.6.99.2	ko:K03474	ko00750,ko01100,map00750,map01100	M00124	R05838	RC01476	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxJ
REGS1_k127_4217933_1	1121472.AQWN01000002_gene2107	2.453e-18	87.0	COG0736@1|root,COG0736@2|Bacteria,1VA0T@1239|Firmicutes,24RC0@186801|Clostridia,262C8@186807|Peptococcaceae	186801|Clostridia	I	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein	acpS	-	2.7.8.7	ko:K00997	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS01470	ACPS
REGS1_k127_4278439_0	289376.THEYE_A0372	1.258e-89	300.0	COG0448@1|root,COG0448@2|Bacteria,3J0BI@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
REGS1_k127_4278439_1	1242864.D187_007036	1.041e-07	60.0	COG1572@1|root,COG1572@2|Bacteria,1QX4M@1224|Proteobacteria	1224|Proteobacteria	S	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,CARDB,CBM_35,F5_F8_type_C
REGS1_k127_4278439_2	795359.TOPB45_0258	6.391e-05	55.0	COG0760@1|root,COG0760@2|Bacteria,2GHR3@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	O	SurA N-terminal domain	-	-	5.2.1.8	ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase_2,SurA_N_3
REGS1_k127_4325303_3	596315.HMPREF0634_0203	6.948e-08	54.0	COG1211@1|root,COG1211@2|Bacteria,1V3M7@1239|Firmicutes,248E6@186801|Clostridia,25RGS@186804|Peptostreptococcaceae	186801|Clostridia	I	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)	ispD	-	2.7.7.60	ko:K00991	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS20335	IspD
REGS1_k127_4325303_0	411459.RUMOBE_03655	5.806e-55	197.0	COG0245@1|root,COG0245@2|Bacteria,1V3P0@1239|Firmicutes,24HCM@186801|Clostridia,3XZW5@572511|Blautia	186801|Clostridia	H	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)	ispF	-	2.7.7.60,4.6.1.12	ko:K01770,ko:K12506	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633,R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD,YgbB
REGS1_k127_4325303_2	1370125.AUWT01000006_gene3243	8.146e-09	65.0	COG5473@1|root,COG5473@2|Bacteria,2GN5K@201174|Actinobacteria,234B0@1762|Mycobacteriaceae	201174|Actinobacteria	J	Zn-ribbon protein possibly nucleic acid-binding	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_4325303_4	471854.Dfer_3244	6.973e-07	59.0	COG1525@1|root,COG1525@2|Bacteria,4NT0S@976|Bacteroidetes	976|Bacteroidetes	L	nuclease	lpxP	-	3.1.31.1	ko:K01174	-	-	-	-	ko00000,ko01000	-	-	-	SNase
REGS1_k127_4325303_5	515635.Dtur_0288	1.522e-06	51.0	COG1028@1|root,COG1028@2|Bacteria	515635.Dtur_0288|-	IQ	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_4325303_1	1167006.UWK_01886	1.71e-22	101.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	cpeZ	-	-	ko:K05384,ko:K05386	ko00196,ko01100,map00196,map01100	-	-	-	ko00000,ko00001,ko00194	-	-	-	HEAT,HEAT_2
REGS1_k127_4331314_2	1278307.KB906975_gene1851	4.444e-53	199.0	COG1262@1|root,COG1262@2|Bacteria,1NQ5K@1224|Proteobacteria,1S2PN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	PFAM Sulphatase-modifying factor	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
REGS1_k127_4331314_0	1244869.H261_15537	2.254e-130	428.0	COG2271@1|root,COG2271@2|Bacteria,1QVY6@1224|Proteobacteria,2TWTV@28211|Alphaproteobacteria,2JZ5K@204441|Rhodospirillales	204441|Rhodospirillales	G	Uncharacterised MFS-type transporter YbfB	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
REGS1_k127_4331314_1	269799.Gmet_2453	2.512e-81	284.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,43TS4@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	response regulator	-	-	-	ko:K02481,ko:K07715	ko02020,ko02024,map02020,map02024	M00502	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
REGS1_k127_4341542_0	56780.SYN_00726	1.836e-34	137.0	COG0589@1|root,COG0589@2|Bacteria,1NY54@1224|Proteobacteria,430VB@68525|delta/epsilon subdivisions,2WW2X@28221|Deltaproteobacteria,2MSCI@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
REGS1_k127_4341542_1	269799.Gmet_3498	6.624e-30	122.0	COG0589@1|root,COG0589@2|Bacteria,1Q0M5@1224|Proteobacteria,430YY@68525|delta/epsilon subdivisions,2WVQA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
REGS1_k127_4380439_0	589865.DaAHT2_2441	1.041e-114	384.0	COG3746@1|root,COG3746@2|Bacteria,1QXPF@1224|Proteobacteria,42TW0@68525|delta/epsilon subdivisions,2WQ4G@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	PFAM Phosphate-selective porin O and P	-	-	-	-	-	-	-	-	-	-	-	-	Porin_O_P
REGS1_k127_4391601_3	1392501.JIAC01000001_gene1134	3.495e-37	147.0	COG0566@1|root,COG0566@2|Bacteria,1V3JP@1239|Firmicutes,4H3JJ@909932|Negativicutes	909932|Negativicutes	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	-	-	-	ko:K03437	-	-	-	-	ko00000,ko03016	-	-	-	SpoU_methylase,SpoU_sub_bind
REGS1_k127_4391601_2	289376.THEYE_A0254	8.532e-81	285.0	COG0544@1|root,COG0544@2|Bacteria,3J12E@40117|Nitrospirae	40117|Nitrospirae	O	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03545	-	-	-	-	ko00000	-	-	-	Trigger_C,Trigger_N
REGS1_k127_4391601_1	289376.THEYE_A0255	2.778e-99	328.0	COG0740@1|root,COG0740@2|Bacteria,3J0A3@40117|Nitrospirae	40117|Nitrospirae	O	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
REGS1_k127_4391601_0	671143.DAMO_2181	1.935e-129	418.0	COG1219@1|root,COG1219@2|Bacteria,2NNN2@2323|unclassified Bacteria	2|Bacteria	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	GO:0000166,GO:0000502,GO:0002020,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009376,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019899,GO:0019904,GO:0030163,GO:0030164,GO:0030312,GO:0030554,GO:0031333,GO:0031597,GO:0032271,GO:0032272,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043254,GO:0043335,GO:0044087,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051301,GO:0051704,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0097718,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1904949,GO:1905368,GO:1905369	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
REGS1_k127_4451240_1	1121918.ARWE01000001_gene285	1.233e-102	342.0	COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,42SPZ@68525|delta/epsilon subdivisions,2WIV9@28221|Deltaproteobacteria,43T8B@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region	nuoG-1	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iAF987.Gmet_3349	Fer2_4,Fer4_10,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
REGS1_k127_4451240_0	177437.HRM2_16600	3.708e-262	820.0	COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,42N6N@68525|delta/epsilon subdivisions,2WJ1W@28221|Deltaproteobacteria,2MJ8N@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Respiratory-chain NADH dehydrogenase domain 51 kDa subunit	-	-	1.12.1.3,1.6.5.2,1.6.5.3	ko:K00124,ko:K00335,ko:K00355,ko:K18331	ko00130,ko00190,ko00630,ko00680,ko01100,ko01110,ko01120,ko01200,ko05200,ko05225,ko05418,map00130,map00190,map00630,map00680,map01100,map01110,map01120,map01200,map05200,map05225,map05418	M00144	R00519,R02964,R03643,R03816,R11945	RC00061,RC00819,RC02796	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
REGS1_k127_4451240_2	706587.Desti_2752	2.804e-37	144.0	COG3411@1|root,COG3411@2|Bacteria,1N1N9@1224|Proteobacteria,42U7G@68525|delta/epsilon subdivisions,2WQFG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Ferredoxin	-	-	1.12.1.3	ko:K17992	-	-	-	-	ko00000,ko01000	-	-	-	-
REGS1_k127_4451240_3	696369.KI912183_gene1328	2.32e-07	53.0	COG1905@1|root,COG1905@2|Bacteria,1V737@1239|Firmicutes,24I29@186801|Clostridia,266VH@186807|Peptococcaceae	186801|Clostridia	C	Thioredoxin-like [2Fe-2S] ferredoxin	-	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
REGS1_k127_4454809_1	909663.KI867150_gene2097	1.07e-99	334.0	COG0042@1|root,COG0042@2|Bacteria,1MV5V@1224|Proteobacteria,42N3M@68525|delta/epsilon subdivisions,2WKM7@28221|Deltaproteobacteria,2MQHB@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	nifR3	-	-	ko:K05540	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
REGS1_k127_4454809_0	289376.THEYE_A0662	3.194e-109	362.0	COG0123@1|root,COG0123@2|Bacteria,3J0P2@40117|Nitrospirae	40117|Nitrospirae	BQ	Histone deacetylase domain	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
REGS1_k127_4454809_2	269799.Gmet_3488	4.276e-26	110.0	2DBVK@1|root,2ZBBH@2|Bacteria,1PWZS@1224|Proteobacteria,432W2@68525|delta/epsilon subdivisions,2WXWI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Ion channel	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2
REGS1_k127_4462144_0	153721.MYP_1412	5.688e-173	561.0	COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria,4NESR@976|Bacteroidetes,47NMI@768503|Cytophagia	976|Bacteroidetes	L	DNA polymerase Ligase (LigD)	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
REGS1_k127_4462144_1	706587.Desti_0133	1.806e-92	316.0	COG3285@1|root,COG3285@2|Bacteria,1MVWY@1224|Proteobacteria,42Z1A@68525|delta/epsilon subdivisions,2WU2C@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	DNA polymerase LigD polymerase domain	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	-
REGS1_k127_4462144_4	290397.Adeh_0963	3.574e-47	180.0	COG1273@1|root,COG1273@2|Bacteria,1N4UX@1224|Proteobacteria,42RD5@68525|delta/epsilon subdivisions,2WMZ1@28221|Deltaproteobacteria,2YV5B@29|Myxococcales	28221|Deltaproteobacteria	L	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD	ku	-	-	ko:K10979	ko03450,map03450	-	-	-	ko00000,ko00001,ko03400	-	-	-	Ku
REGS1_k127_4462144_3	401526.TcarDRAFT_0620	1.037e-48	183.0	COG1273@1|root,COG1273@2|Bacteria,1TSY5@1239|Firmicutes,4H2SP@909932|Negativicutes	909932|Negativicutes	L	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD	ku	-	-	ko:K10979	ko03450,map03450	-	-	-	ko00000,ko00001,ko03400	-	-	-	Ku
REGS1_k127_4462144_2	1123376.AUIU01000012_gene1419	2.162e-60	214.0	COG0163@1|root,COG0163@2|Bacteria	2|Bacteria	H	prenyltransferase activity	ubiX	GO:0003674,GO:0003824,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008694,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663	2.5.1.129	ko:K03186,ko:K16875	ko00130,ko00365,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00365,map00627,map00940,map01100,map01110,map01120,map01220	M00117	R01238,R02952,R03367,R04985,R04986,R10213,R11225	RC00391,RC00814,RC03086,RC03392	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b2311,iAF987.Gmet_3392,iAPECO1_1312.APECO1_4253,iB21_1397.B21_02196,iBWG_1329.BWG_2085,iE2348C_1286.E2348C_2451,iEC55989_1330.EC55989_2555,iECBD_1354.ECBD_1348,iECB_1328.ECB_02236,iECDH10B_1368.ECDH10B_2473,iECDH1ME8569_1439.ECDH1ME8569_2249,iECD_1391.ECD_02236,iECED1_1282.ECED1_2775,iECH74115_1262.ECH74115_3451,iECIAI39_1322.ECIAI39_2460,iECNA114_1301.ECNA114_2401,iECO103_1326.ECO103_2775,iECOK1_1307.ECOK1_2544,iECP_1309.ECP_2350,iECS88_1305.ECS88_2458,iECSE_1348.ECSE_2620,iECSF_1327.ECSF_2187,iECSP_1301.ECSP_3186,iECs_1301.ECs3195,iETEC_1333.ETEC_2447,iEcDH1_1363.EcDH1_1345,iEcE24377_1341.EcE24377A_2605,iEcHS_1320.EcHS_A2462,iEcSMS35_1347.EcSMS35_2467,iG2583_1286.G2583_2848,iJO1366.b2311,iJR904.b2311,iLF82_1304.LF82_2354,iNRG857_1313.NRG857_11705,iSDY_1059.SDY_2510,iUMN146_1321.UM146_05255,iUMNK88_1353.UMNK88_2862,iUTI89_1310.UTI89_C2595,iY75_1357.Y75_RS12120,iZ_1308.Z3573	Flavoprotein
REGS1_k127_4465791_2	1220534.B655_1300	4.155e-78	264.0	COG1488@1|root,arCOG01481@2157|Archaea,2XU8Y@28890|Euryarchaeota	28890|Euryarchaeota	H	Nicotinic acid phosphoribosyltransferase	pncB	-	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	-	QRPTase_C,QRPTase_N
REGS1_k127_4465791_3	269799.Gmet_1009	4.136e-68	237.0	COG1881@1|root,COG1881@2|Bacteria,1N0Y4@1224|Proteobacteria,42T3J@68525|delta/epsilon subdivisions,2X5P0@28221|Deltaproteobacteria,43W2U@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Phosphatidylethanolamine-binding protein	-	-	-	ko:K06910	-	-	-	-	ko00000	-	-	-	PBP
REGS1_k127_4465791_0	671143.DAMO_2884	2.488e-319	992.0	COG0296@1|root,COG0296@2|Bacteria	2|Bacteria	G	1,4-alpha-glucan branching enzyme activity	glgB	GO:0000271,GO:0003674,GO:0003824,GO:0003844,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0055114,GO:0071704,GO:1901576	2.4.1.18,3.2.1.141	ko:K00700,ko:K01236	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110,R09995,R11256	RC00049	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
REGS1_k127_4465791_1	404380.Gbem_0296	1.57e-104	354.0	COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,42N5S@68525|delta/epsilon subdivisions,2WIUS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Adenylyl cyclase class-3 4 guanylyl cyclase	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc
REGS1_k127_4485467_1	75379.Tint_2511	6.533e-18	87.0	COG2010@1|root,COG2010@2|Bacteria,1NJ3U@1224|Proteobacteria,2VYBQ@28216|Betaproteobacteria	28216|Betaproteobacteria	C	cytochrome C oxidoreductase subunit B	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_4485467_0	264198.Reut_A3083	1.021e-130	429.0	COG2041@1|root,COG2041@2|Bacteria,1MX9E@1224|Proteobacteria,2VK72@28216|Betaproteobacteria,1JZY2@119060|Burkholderiaceae	28216|Betaproteobacteria	S	C oxidoreductase subunit A	sorA	-	-	-	-	-	-	-	-	-	-	-	Mo-co_dimer,Oxidored_molyb
REGS1_k127_449823_2	1123376.AUIU01000012_gene1597	4.101e-46	173.0	COG1376@1|root,COG1388@1|root,COG1376@2|Bacteria,COG1388@2|Bacteria	2|Bacteria	M	LysM domain	mltD	-	-	ko:K08307,ko:K12204,ko:K16291	-	-	-	-	ko00000,ko01000,ko01002,ko01011,ko02044	3.A.7.10.1,3.A.7.9.1	-	-	LysM,SLT,T4SS_TraI,YkuD
REGS1_k127_449823_0	398767.Glov_1256	1.133e-86	290.0	COG1704@1|root,COG1704@2|Bacteria,1MVH0@1224|Proteobacteria,42R4C@68525|delta/epsilon subdivisions,2WKG9@28221|Deltaproteobacteria,43S01@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	PFAM LemA family protein	-	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
REGS1_k127_449823_1	909663.KI867150_gene1033	5.897e-82	281.0	COG1512@1|root,COG1512@2|Bacteria,1PB41@1224|Proteobacteria,42R0Q@68525|delta/epsilon subdivisions,2WN87@28221|Deltaproteobacteria,2MS9N@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	TPM domain	-	-	-	ko:K06872	-	-	-	-	ko00000	-	-	-	TPM_phosphatase
REGS1_k127_4515779_0	589865.DaAHT2_0436	2.844e-105	355.0	COG0577@1|root,COG0577@2|Bacteria,1R5BD@1224|Proteobacteria	1224|Proteobacteria	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
REGS1_k127_4515779_2	589865.DaAHT2_0437	5.943e-83	282.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,4308T@68525|delta/epsilon subdivisions,2WKJ3@28221|Deltaproteobacteria,2MIDE@213118|Desulfobacterales	28221|Deltaproteobacteria	V	PFAM ABC transporter related	lolD-2	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
REGS1_k127_4515779_1	330214.NIDE3218	5.851e-105	347.0	COG0388@1|root,COG0388@2|Bacteria,3J11H@40117|Nitrospirae	40117|Nitrospirae	S	Carbon-nitrogen hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
REGS1_k127_4515779_3	1232410.KI421421_gene3574	5.98e-05	46.0	COG4393@1|root,COG4393@2|Bacteria,1R507@1224|Proteobacteria,42NQA@68525|delta/epsilon subdivisions,2WQ0C@28221|Deltaproteobacteria,43VBI@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Predicted membrane protein (DUF2318)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2318
REGS1_k127_453583_0	1499967.BAYZ01000118_gene3292	1.707e-151	505.0	COG2804@1|root,COG2804@2|Bacteria,2NNNI@2323|unclassified Bacteria	2|Bacteria	NU	Type II secretion system (T2SS), protein E, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	T2SSE,T2SSE_N
REGS1_k127_453583_3	459495.SPLC1_S051580	1.237e-58	205.0	COG0745@1|root,COG0745@2|Bacteria,1G5XG@1117|Cyanobacteria,1HB6Y@1150|Oscillatoriales	1117|Cyanobacteria	T	Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
REGS1_k127_453583_5	647113.Metok_0186	4.38e-17	95.0	COG1148@1|root,arCOG02235@2157|Archaea,2XT3X@28890|Euryarchaeota,23QA9@183939|Methanococci	183939|Methanococci	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Pyr_redox_2
REGS1_k127_453583_4	1121403.AUCV01000001_gene776	5.026e-21	108.0	COG1148@1|root,COG1908@1|root,COG1148@2|Bacteria,COG1908@2|Bacteria,1R68U@1224|Proteobacteria,42M71@68525|delta/epsilon subdivisions,2WKG0@28221|Deltaproteobacteria,2MJ02@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Methyl-viologen-reducing hydrogenase, delta subunit	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,FlpD
REGS1_k127_453583_2	523845.AQXV01000051_gene1214	7.729e-67	239.0	COG1941@1|root,arCOG02472@2157|Archaea,2XV6A@28890|Euryarchaeota,23QG6@183939|Methanococci	183939|Methanococci	C	PFAM NADH ubiquinone oxidoreductase 20 kDa subunit	-	-	1.8.98.5	ko:K14128	ko00680,map00680	-	R00019,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	Oxidored_q6
REGS1_k127_453583_1	386456.JQKN01000001_gene1862	2.208e-70	245.0	COG0374@1|root,arCOG01549@2157|Archaea,2XTHE@28890|Euryarchaeota,23NPA@183925|Methanobacteria	183925|Methanobacteria	C	Belongs to the NiFe NiFeSe hydrogenase large subunit family	-	-	1.8.98.5	ko:K14126	ko00680,map00680	-	R00019,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
REGS1_k127_4585037_0	706587.Desti_0850	6.442e-108	377.0	COG0745@1|root,COG2202@1|root,COG2203@1|root,COG4191@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIU5@28221|Deltaproteobacteria,2MQZQ@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
REGS1_k127_4585037_1	1121403.AUCV01000031_gene2838	6.83e-21	104.0	COG1361@1|root,COG3540@1|root,COG4733@1|root,COG1361@2|Bacteria,COG3540@2|Bacteria,COG4733@2|Bacteria,1QVSF@1224|Proteobacteria	1224|Proteobacteria	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,OmpA_membrane
REGS1_k127_4585868_4	289376.THEYE_A0236	1.195e-25	112.0	COG0711@1|root,COG0711@2|Bacteria	2|Bacteria	C	ATP synthesis coupled proton transport	atpF	GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0016020,GO:0016469,GO:0032991,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045259,GO:0045260,GO:0071944,GO:0098796,GO:0098797	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
REGS1_k127_4585868_2	289376.THEYE_A0237	1.622e-39	157.0	COG0711@1|root,COG0711@2|Bacteria	2|Bacteria	C	ATP synthesis coupled proton transport	atpF	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045263,GO:0045264,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02109,ko:K18682	ko00190,ko00195,ko01100,ko03018,map00190,map00195,map01100,map03018	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000,ko03019	3.A.2.1	-	-	ATP-synt_B
REGS1_k127_4585868_3	1123376.AUIU01000011_gene1098	2.362e-39	152.0	COG0712@1|root,COG0712@2|Bacteria,3J1BY@40117|Nitrospirae	40117|Nitrospirae	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	-	-	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	OSCP
REGS1_k127_4585868_0	289376.THEYE_A0239	9.452e-243	758.0	COG0056@1|root,COG0056@2|Bacteria,3J0CZ@40117|Nitrospirae	40117|Nitrospirae	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
REGS1_k127_4585868_1	289376.THEYE_A0240	6.83e-64	224.0	COG0224@1|root,COG0224@2|Bacteria,3J0J8@40117|Nitrospirae	40117|Nitrospirae	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	-	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
REGS1_k127_4605975_4	909663.KI867150_gene2952	3.844e-34	133.0	COG0861@1|root,COG0861@2|Bacteria,1QZU6@1224|Proteobacteria,42S1Q@68525|delta/epsilon subdivisions,2WNNS@28221|Deltaproteobacteria,2MQEU@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	PFAM Integral membrane protein TerC	-	-	-	-	-	-	-	-	-	-	-	-	TerC
REGS1_k127_4605975_2	909663.KI867150_gene2953	6.311e-74	257.0	COG1102@1|root,COG1102@2|Bacteria,1R4GX@1224|Proteobacteria,42QKV@68525|delta/epsilon subdivisions,2X6GW@28221|Deltaproteobacteria,2MRNW@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	Cytidylate kinase-like family	-	-	-	-	-	-	-	-	-	-	-	-	Cytidylate_kin2
REGS1_k127_4605975_3	909663.KI867150_gene921	1.758e-46	169.0	COG0507@1|root,COG0507@2|Bacteria,1MW43@1224|Proteobacteria,42M8J@68525|delta/epsilon subdivisions,2WJD6@28221|Deltaproteobacteria,2MQAU@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity	recD2	-	3.1.11.5	ko:K03581	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_30,HHH_4,HHH_5,UvrD_C_2
REGS1_k127_4605975_0	909663.KI867150_gene921	3.27e-244	767.0	COG0507@1|root,COG0507@2|Bacteria,1MW43@1224|Proteobacteria,42M8J@68525|delta/epsilon subdivisions,2WJD6@28221|Deltaproteobacteria,2MQAU@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity	recD2	-	3.1.11.5	ko:K03581	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_30,HHH_4,HHH_5,UvrD_C_2
REGS1_k127_4605975_1	289376.THEYE_A0372	1.204e-84	283.0	COG0448@1|root,COG0448@2|Bacteria,3J0BI@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
REGS1_k127_461940_0	1167006.UWK_02855	2.87e-178	570.0	COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42N46@68525|delta/epsilon subdivisions,2WJT4@28221|Deltaproteobacteria,2MPMZ@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,PocR,Response_reg
REGS1_k127_461940_1	883126.HMPREF9710_04699	2.548e-97	329.0	COG3181@1|root,COG3181@2|Bacteria,1MW18@1224|Proteobacteria,2VHVS@28216|Betaproteobacteria,472N8@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
REGS1_k127_4635105_2	289376.THEYE_A0930	1.443e-96	325.0	COG0774@1|root,COG0774@2|Bacteria,3J0JG@40117|Nitrospirae	40117|Nitrospirae	M	Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis	lpxC	-	3.5.1.108	ko:K02535	ko00540,ko01100,map00540,map01100	M00060	R04587	RC00166,RC00300	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxC
REGS1_k127_4635105_0	269799.Gmet_2720	8.391e-166	533.0	COG0312@1|root,COG0312@2|Bacteria,1MUSK@1224|Proteobacteria,42QCV@68525|delta/epsilon subdivisions,2WJP8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Peptidase U62 modulator of DNA gyrase	tldD	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
REGS1_k127_4635105_3	1123376.AUIU01000012_gene1416	6.57e-76	262.0	COG0005@1|root,COG0005@2|Bacteria,3J0HC@40117|Nitrospirae	40117|Nitrospirae	F	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates	mtnP	-	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
REGS1_k127_4635105_1	1379698.RBG1_1C00001G1265	4.254e-98	326.0	COG2204@1|root,COG2204@2|Bacteria,2NNWS@2323|unclassified Bacteria	2|Bacteria	T	Two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
REGS1_k127_4638953_1	289376.THEYE_A1849	1.498e-101	342.0	COG0467@1|root,COG1396@1|root,COG1917@1|root,COG0467@2|Bacteria,COG1396@2|Bacteria,COG1917@2|Bacteria,3J0VE@40117|Nitrospirae	40117|Nitrospirae	K	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,HTH_3
REGS1_k127_4638953_2	1392502.JNIO01000007_gene1113	5.897e-85	294.0	COG0067@1|root,COG0067@2|Bacteria,1TQX1@1239|Firmicutes,4H35M@909932|Negativicutes	909932|Negativicutes	E	PFAM Glutamine amidotransferase, class-II	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_4638953_0	289376.THEYE_A1687	2.787e-193	609.0	COG0069@1|root,COG1149@1|root,COG0069@2|Bacteria,COG1149@2|Bacteria,3J0SV@40117|Nitrospirae	40117|Nitrospirae	C	Conserved region in glutamate synthase	-	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
REGS1_k127_464031_1	404589.Anae109_1805	1.1e-80	275.0	COG3005@1|root,COG3005@2|Bacteria,1QYG3@1224|Proteobacteria,43CC8@68525|delta/epsilon subdivisions,2X7N4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Cytochrome c3	-	-	-	-	-	-	-	-	-	-	-	-	Paired_CXXCH_1
REGS1_k127_464031_2	290397.Adeh_2001	1.203e-65	232.0	COG2864@1|root,COG2864@2|Bacteria,1NJEJ@1224|Proteobacteria,42NQM@68525|delta/epsilon subdivisions,2WK76@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	denitrification pathway	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB
REGS1_k127_464031_0	404589.Anae109_1809	3.114e-83	299.0	COG4585@1|root,COG4585@2|Bacteria,1N0JE@1224|Proteobacteria,42UG3@68525|delta/epsilon subdivisions,2WQFT@28221|Deltaproteobacteria,2Z1DF@29|Myxococcales	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA_3
REGS1_k127_464031_3	404589.Anae109_1810	2.408e-65	229.0	COG2197@1|root,COG2197@2|Bacteria,1R9GN@1224|Proteobacteria,42PU2@68525|delta/epsilon subdivisions,2X60T@28221|Deltaproteobacteria,2Z327@29|Myxococcales	28221|Deltaproteobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
REGS1_k127_4644627_4	1123400.KB904780_gene1850	5.496e-05	50.0	COG4967@1|root,COG4967@2|Bacteria,1N992@1224|Proteobacteria,1T2RT@1236|Gammaproteobacteria,463TR@72273|Thiotrichales	72273|Thiotrichales	NU	Prokaryotic N-terminal methylation motif	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl
REGS1_k127_4644627_6	870187.Thini_3449	0.0002602	51.0	COG2165@1|root,COG2165@2|Bacteria,1NH1V@1224|Proteobacteria,1SFJC@1236|Gammaproteobacteria,463DQ@72273|Thiotrichales	72273|Thiotrichales	NU	Prokaryotic N-terminal methylation motif	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl
REGS1_k127_4644627_0	933262.AXAM01000042_gene1817	5.066e-46	179.0	COG1555@1|root,COG3156@1|root,COG1555@2|Bacteria,COG3156@2|Bacteria,1PQMW@1224|Proteobacteria,42T9B@68525|delta/epsilon subdivisions,2WPYT@28221|Deltaproteobacteria,2MKAN@213118|Desulfobacterales	28221|Deltaproteobacteria	LU	Type II secretion system (T2SS), protein K	-	-	-	ko:K02460	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSK
REGS1_k127_4644627_3	1249627.D779_0860	2.17e-08	67.0	COG3166@1|root,COG3166@2|Bacteria,1RJTG@1224|Proteobacteria,1S6RT@1236|Gammaproteobacteria,1WXKF@135613|Chromatiales	135613|Chromatiales	NU	fimbrial assembly	-	-	-	ko:K02461	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	PilM_2,PilN
REGS1_k127_4644627_2	1123399.AQVE01000023_gene419	5.389e-09	69.0	COG3166@1|root,COG3166@2|Bacteria,1RJTG@1224|Proteobacteria,1S6RT@1236|Gammaproteobacteria,4633V@72273|Thiotrichales	72273|Thiotrichales	NU	Fimbrial assembly protein (PilN)	-	-	-	-	-	-	-	-	-	-	-	-	PilN
REGS1_k127_4644627_1	713586.KB900536_gene2476	1.377e-09	66.0	2DKUH@1|root,30CV1@2|Bacteria,1NCRM@1224|Proteobacteria,1S4X4@1236|Gammaproteobacteria,1WY93@135613|Chromatiales	135613|Chromatiales	S	General secretion pathway protein M	-	-	-	ko:K02462	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSM_b
REGS1_k127_4644627_7	177437.HRM2_30120	0.0005313	51.0	28QJI@1|root,2ZD1D@2|Bacteria,1P6BU@1224|Proteobacteria,433FY@68525|delta/epsilon subdivisions,2WY3H@28221|Deltaproteobacteria,2MP4N@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_4650514_2	909663.KI867149_gene3360	8.227e-62	217.0	COG1463@1|root,COG1463@2|Bacteria,1NCUG@1224|Proteobacteria,42SCT@68525|delta/epsilon subdivisions,2WPA7@28221|Deltaproteobacteria,2MQJI@213462|Syntrophobacterales	28221|Deltaproteobacteria	Q	MlaD protein	-	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
REGS1_k127_4650514_0	909663.KI867149_gene3359	1.319e-169	544.0	COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,42NI4@68525|delta/epsilon subdivisions,2WKRT@28221|Deltaproteobacteria,2MQX9@213462|Syntrophobacterales	28221|Deltaproteobacteria	Q	ABC transporter	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran,GGDEF
REGS1_k127_4650514_1	909663.KI867149_gene3358	3.925e-98	323.0	COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,42MR1@68525|delta/epsilon subdivisions,2WKC9@28221|Deltaproteobacteria,2MQW9@213462|Syntrophobacterales	28221|Deltaproteobacteria	Q	Permease MlaE	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
REGS1_k127_4697726_1	314345.SPV1_01847	1.591e-161	515.0	COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria	1224|Proteobacteria	V	Abc-type multidrug transport system, permease component	ybhR	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006855,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0015562,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0033554,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0071944	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
REGS1_k127_4697726_2	335543.Sfum_2392	8.157e-156	500.0	COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,42P7V@68525|delta/epsilon subdivisions,2WJQA@28221|Deltaproteobacteria,2MQ5A@213462|Syntrophobacterales	28221|Deltaproteobacteria	V	ABC-2 family transporter protein	ybhS	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_3
REGS1_k127_4697726_0	335543.Sfum_2391	5.71e-253	794.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,42MV1@68525|delta/epsilon subdivisions,2WK9W@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	PFAM ABC transporter	-	-	-	ko:K01990,ko:K01992,ko:K09695	ko02010,map02010	M00252,M00254	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.102	-	-	ABC2_membrane_3,ABC_tran
REGS1_k127_4697726_4	1454004.AW11_02751	2.269e-104	349.0	COG0845@1|root,COG0845@2|Bacteria,1MUG6@1224|Proteobacteria,2VH7G@28216|Betaproteobacteria	28216|Betaproteobacteria	M	PFAM secretion protein HlyD family protein	-	-	-	ko:K01993,ko:K16922	-	-	-	-	ko00000,ko01002	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
REGS1_k127_4697726_3	1121438.JNJA01000005_gene995	8.87e-130	428.0	COG0642@1|root,COG2205@2|Bacteria,1QHXX@1224|Proteobacteria,42NW1@68525|delta/epsilon subdivisions,2WJUF@28221|Deltaproteobacteria,2M85B@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	PFAM ATP-binding region ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
REGS1_k127_4697726_6	909663.KI867150_gene2165	1.539e-32	139.0	COG3170@1|root,COG3170@2|Bacteria,1NHGQ@1224|Proteobacteria,42X64@68525|delta/epsilon subdivisions,2WSMQ@28221|Deltaproteobacteria,2MQPS@213462|Syntrophobacterales	28221|Deltaproteobacteria	NU	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	DUF2275,zf-HC2
REGS1_k127_4697726_5	909663.KI867150_gene2166	1.908e-67	233.0	COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,42U04@68525|delta/epsilon subdivisions,2WQA9@28221|Deltaproteobacteria,2MRPA@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
REGS1_k127_4709036_0	1123368.AUIS01000010_gene2358	3.917e-106	352.0	COG2081@1|root,COG2081@2|Bacteria,1MUGC@1224|Proteobacteria,1RNCW@1236|Gammaproteobacteria,2NBRS@225057|Acidithiobacillales	225057|Acidithiobacillales	S	HI0933-like protein	-	-	-	ko:K07007	-	-	-	-	ko00000	-	-	-	HI0933_like
REGS1_k127_4709036_1	1042163.BRLA_c012410	4.673e-49	183.0	COG0424@1|root,COG0424@2|Bacteria,1V6FH@1239|Firmicutes,4HIMK@91061|Bacilli,26X4A@186822|Paenibacillaceae	91061|Bacilli	D	Maf-like protein	maf	GO:0000278,GO:0000281,GO:0000910,GO:0000917,GO:0005575,GO:0005623,GO:0007049,GO:0008150,GO:0009987,GO:0016043,GO:0022402,GO:0022607,GO:0030428,GO:0032506,GO:0044085,GO:0044464,GO:0051301,GO:0061640,GO:0071840,GO:0090529,GO:1902410,GO:1903047	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
REGS1_k127_474209_8	443144.GM21_0268	5.312e-34	134.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WKJX@28221|Deltaproteobacteria,43S25@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Domains REC, sigma54 interaction, HTH8	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
REGS1_k127_474209_5	1232410.KI421428_gene1053	2.38e-68	251.0	COG4191@1|root,COG4191@2|Bacteria,1N2VE@1224|Proteobacteria,43AY6@68525|delta/epsilon subdivisions,2X6CJ@28221|Deltaproteobacteria,43T05@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
REGS1_k127_474209_3	1123376.AUIU01000014_gene704	4.001e-109	363.0	COG0755@1|root,COG0755@2|Bacteria,3J0NY@40117|Nitrospirae	40117|Nitrospirae	O	Cytochrome C assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
REGS1_k127_474209_2	589865.DaAHT2_0780	2.281e-117	393.0	COG1333@1|root,COG1333@2|Bacteria,1N6XE@1224|Proteobacteria,42NBB@68525|delta/epsilon subdivisions,2WIMD@28221|Deltaproteobacteria,2MIEB@213118|Desulfobacterales	28221|Deltaproteobacteria	O	PFAM ResB family protein	-	-	-	ko:K07399	-	-	-	-	ko00000	-	-	-	ResB
REGS1_k127_474209_7	1123376.AUIU01000014_gene603	1.937e-38	149.0	COG1917@1|root,COG1917@2|Bacteria	2|Bacteria	L	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,DUF4440
REGS1_k127_474209_0	1123376.AUIU01000014_gene601	2.603e-131	428.0	COG1063@1|root,COG1063@2|Bacteria	2|Bacteria	E	alcohol dehydrogenase	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
REGS1_k127_474209_4	443143.GM18_2049	6.08e-87	296.0	COG1801@1|root,COG1801@2|Bacteria,1N4QE@1224|Proteobacteria,42PDW@68525|delta/epsilon subdivisions,2WK6H@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
REGS1_k127_474209_1	1123376.AUIU01000018_gene79	3.224e-122	400.0	COG1063@1|root,COG1063@2|Bacteria,3J1FG@40117|Nitrospirae	40117|Nitrospirae	E	Glucose dehydrogenase C-terminus	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
REGS1_k127_474209_9	768670.Calni_1347	4.837e-17	83.0	28ISQ@1|root,33DSE@2|Bacteria,2GG1G@200930|Deferribacteres	200930|Deferribacteres	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_474209_6	1499967.BAYZ01000074_gene2175	5.099e-55	196.0	COG4277@1|root,COG4277@2|Bacteria	2|Bacteria	-	-	MA20_15955	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	HHH_3,Radical_SAM
REGS1_k127_4757144_7	113355.CM001775_gene4048	5.812e-47	177.0	COG1232@1|root,COG1232@2|Bacteria,1G05M@1117|Cyanobacteria	1117|Cyanobacteria	H	Protoporphyrinogen oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
REGS1_k127_4757144_0	589865.DaAHT2_2411	3.125e-216	681.0	COG1032@1|root,COG1032@2|Bacteria,1MWR0@1224|Proteobacteria,42PFW@68525|delta/epsilon subdivisions,2WJ1N@28221|Deltaproteobacteria,2MI4U@213118|Desulfobacterales	28221|Deltaproteobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
REGS1_k127_4757144_5	237368.SCABRO_03971	2.166e-55	197.0	COG4807@1|root,COG4807@2|Bacteria	2|Bacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF1456
REGS1_k127_4757144_4	443143.GM18_0292	7.342e-97	320.0	COG0225@1|root,COG0225@2|Bacteria,1R33Z@1224|Proteobacteria,42RS2@68525|delta/epsilon subdivisions,2X9GK@28221|Deltaproteobacteria,43W2H@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
REGS1_k127_4757144_8	671143.DAMO_1988	5.176e-45	173.0	COG1262@1|root,COG1262@2|Bacteria,2NR8C@2323|unclassified Bacteria	2|Bacteria	S	Sulfatase-modifying factor enzyme 1	-	-	1.14.99.50	ko:K18912	ko00340,map00340	-	R11013	RC03323,RC03324	ko00000,ko00001,ko01000	-	-	-	FGE-sulfatase
REGS1_k127_4757144_1	1124780.ANNU01000023_gene3214	5.286e-112	377.0	COG1570@1|root,COG1570@2|Bacteria,4NE64@976|Bacteroidetes,47NEW@768503|Cytophagia	976|Bacteroidetes	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
REGS1_k127_4757144_15	1408473.JHXO01000006_gene1172	5.845e-11	66.0	COG1722@1|root,COG1722@2|Bacteria	2|Bacteria	L	exodeoxyribonuclease VII activity	xseB	-	3.1.11.6	ko:K03602	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_S
REGS1_k127_4757144_12	644281.MFS40622_1398	4.503e-19	95.0	COG1418@1|root,arCOG01858@2157|Archaea,2XY7Y@28890|Euryarchaeota,23R1B@183939|Methanococci	183939|Methanococci	S	PFAM metal-dependent phosphohydrolase, HD sub domain	-	-	-	ko:K06950	-	-	-	-	ko00000	-	-	-	HD
REGS1_k127_4757144_14	439235.Dalk_3347	6.878e-13	70.0	COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,42QPM@68525|delta/epsilon subdivisions,2WMRG@28221|Deltaproteobacteria,2MI75@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	-	ECH_1
REGS1_k127_4757144_11	1122179.KB890443_gene1191	1.823e-20	100.0	COG3527@1|root,COG3527@2|Bacteria,4NKWJ@976|Bacteroidetes	976|Bacteroidetes	Q	Alpha-acetolactate decarboxylase	-	-	4.1.1.5	ko:K01575	ko00650,ko00660,map00650,map00660	-	R02948	RC00812	ko00000,ko00001,ko01000	-	-	-	AAL_decarboxy
REGS1_k127_4757144_17	1121468.AUBR01000054_gene1456	1.65e-08	59.0	COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia,42IAF@68295|Thermoanaerobacterales	186801|Clostridia	T	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer).	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,HAMP,MCPsignal
REGS1_k127_4757144_13	1408823.AXUS01000073_gene990	8.59e-14	74.0	2DR59@1|root,33A7S@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_4757144_9	330214.NIDE3738	4.928e-40	157.0	COG0741@1|root,COG0741@2|Bacteria,3J19T@40117|Nitrospirae	40117|Nitrospirae	M	Transglycosylase SLT domain	-	-	-	-	-	-	-	-	-	-	-	-	SLT
REGS1_k127_4757144_2	1123376.AUIU01000015_gene509	1.691e-111	368.0	COG0379@1|root,COG0379@2|Bacteria,3J0NV@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	-	NadA
REGS1_k127_4757144_10	247490.KSU1_D0452	9.412e-40	160.0	COG0859@1|root,COG0859@2|Bacteria,2J4DC@203682|Planctomycetes	203682|Planctomycetes	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9
REGS1_k127_4757144_16	1121438.JNJA01000007_gene1726	1.268e-09	64.0	COG1406@1|root,COG1406@2|Bacteria,1N7TT@1224|Proteobacteria,43BHP@68525|delta/epsilon subdivisions,2X6W6@28221|Deltaproteobacteria,2M8TV@213115|Desulfovibrionales	28221|Deltaproteobacteria	N	Chemotaxis phosphatase CheX	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_4757144_6	289376.THEYE_A1388	9.991e-54	192.0	COG0590@1|root,COG0590@2|Bacteria,3J0PE@40117|Nitrospirae	40117|Nitrospirae	FJ	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)	tadA	-	3.5.4.33	ko:K11991	-	-	R10223	RC00477	ko00000,ko01000,ko03016	-	-	-	MafB19-deam
REGS1_k127_4757144_3	292564.Cyagr_0200	5.793e-98	331.0	COG0598@1|root,COG0598@2|Bacteria,1G1AG@1117|Cyanobacteria	1117|Cyanobacteria	P	Mediates influx of magnesium ions	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
REGS1_k127_4769001_0	880073.Calab_2422	5.11e-126	423.0	COG1449@1|root,COG1449@2|Bacteria,2NQNB@2323|unclassified Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 57 family	amyA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.4.1.25	ko:K22451	ko00500,map00500	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH57	-	DUF1925,DUF1926,Glyco_hydro_57
REGS1_k127_4769001_2	1123376.AUIU01000013_gene1792	1.291e-75	276.0	2EPNU@1|root,33H9F@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_4769001_1	1158338.JNLJ01000001_gene900	2.66e-77	266.0	COG0020@1|root,COG0020@2|Bacteria,2G3Y0@200783|Aquificae	200783|Aquificae	H	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS	GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
REGS1_k127_4771070_4	1379698.RBG1_1C00001G1750	2.289e-26	117.0	COG0457@1|root,COG0457@2|Bacteria,2NRMR@2323|unclassified Bacteria	2|Bacteria	O	heat shock protein binding	-	-	-	-	-	-	-	-	-	-	-	-	DUF4388
REGS1_k127_4771070_2	1123376.AUIU01000012_gene1328	6.689e-61	215.0	COG2078@1|root,COG2078@2|Bacteria	2|Bacteria	S	ferrous iron binding	amrA	-	-	ko:K06990,ko:K09141	-	-	-	-	ko00000,ko04812	-	-	-	AMMECR1,LigB
REGS1_k127_4771070_1	1123376.AUIU01000015_gene476	1.593e-100	338.0	COG0142@1|root,COG0142@2|Bacteria,3J0H0@40117|Nitrospirae	40117|Nitrospirae	H	Polyprenyl synthetase	-	-	2.5.1.90	ko:K02523	ko00900,ko01110,map00900,map01110	-	R09248	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
REGS1_k127_4771070_0	289376.THEYE_A1501	7.381e-124	406.0	COG0182@1|root,COG0182@2|Bacteria,3J0G0@40117|Nitrospirae	40117|Nitrospirae	E	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	mtnA	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0019509,GO:0019752,GO:0043094,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046523,GO:0071265,GO:0071267,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	-	IF-2B
REGS1_k127_4771070_3	289376.THEYE_A0249	1.474e-48	177.0	COG4198@1|root,COG4198@2|Bacteria,3J0IE@40117|Nitrospirae	40117|Nitrospirae	S	Protein of unknown function (DUF1015)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1015
REGS1_k127_4774114_1	1232410.KI421412_gene129	2.376e-78	270.0	COG2234@1|root,COG2234@2|Bacteria,1MXZS@1224|Proteobacteria,42S82@68525|delta/epsilon subdivisions,2WNUR@28221|Deltaproteobacteria,43TZW@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
REGS1_k127_4774114_0	909663.KI867151_gene3153	1.052e-191	606.0	COG1379@1|root,COG1379@2|Bacteria,1QYWZ@1224|Proteobacteria,43CDU@68525|delta/epsilon subdivisions,2X7PS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_4804698_2	269799.Gmet_2818	9.474e-51	187.0	COG0784@1|root,COG2202@1|root,COG2208@1|root,COG3829@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2208@2|Bacteria,COG3829@2|Bacteria,1NC9X@1224|Proteobacteria,43C4D@68525|delta/epsilon subdivisions,2X7EU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Domains REC, PAS, PAS, PP2C	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	PAS_3,PAS_9,Response_reg,SpoIIE
REGS1_k127_4804698_1	63737.Npun_F3676	2.009e-61	214.0	COG0745@1|root,COG0745@2|Bacteria,1G79X@1117|Cyanobacteria,1HS8I@1161|Nostocales	1117|Cyanobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
REGS1_k127_4804698_3	706587.Desti_3079	2.377e-07	62.0	COG4733@1|root,COG4733@2|Bacteria,1NA5J@1224|Proteobacteria,42WEQ@68525|delta/epsilon subdivisions,2WSA0@28221|Deltaproteobacteria,2MSD2@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Fibronectin type 3 domain	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_4804698_0	1123376.AUIU01000016_gene291	1.939e-155	498.0	COG0165@1|root,COG0165@2|Bacteria,3J0EN@40117|Nitrospirae	40117|Nitrospirae	E	Argininosuccinate lyase C-terminal	argH	-	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
REGS1_k127_4836520_1	1121403.AUCV01000037_gene4267	2.011e-24	114.0	COG2911@1|root,COG3210@1|root,COG4733@1|root,COG4870@1|root,COG2911@2|Bacteria,COG3210@2|Bacteria,COG4733@2|Bacteria,COG4870@2|Bacteria,1P8N9@1224|Proteobacteria	1224|Proteobacteria	MU	HemY domain protein	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_3_2,DUF1573,DUF5122,SWM_repeat
REGS1_k127_4836520_0	340099.Teth39_1632	6.548e-54	203.0	COG0438@1|root,COG0438@2|Bacteria,1UASH@1239|Firmicutes,248VW@186801|Clostridia,42GN4@68295|Thermoanaerobacterales	186801|Clostridia	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
REGS1_k127_4843622_4	289376.THEYE_A0660	7.073e-17	80.0	COG0279@1|root,COG0279@2|Bacteria,3J0HG@40117|Nitrospirae	40117|Nitrospirae	G	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate	gmhA	-	5.3.1.28	ko:K03271	ko00540,ko01100,map00540,map01100	M00064	R05645,R09768,R09769	RC00434	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	SIS_2
REGS1_k127_4843622_3	1487923.DP73_02570	1.016e-38	154.0	COG0817@1|root,COG0817@2|Bacteria,1V3N9@1239|Firmicutes,24HMI@186801|Clostridia,261I9@186807|Peptococcaceae	186801|Clostridia	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group	ruvC	-	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
REGS1_k127_4843622_2	1131269.AQVV01000002_gene1184	3.801e-47	175.0	COG0632@1|root,COG0632@2|Bacteria	2|Bacteria	L	four-way junction helicase activity	ruvA	GO:0000217,GO:0000400,GO:0000724,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009378,GO:0009379,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0022607,GO:0031668,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051276,GO:0051289,GO:0051716,GO:0065003,GO:0071103,GO:0071496,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
REGS1_k127_4843622_0	289376.THEYE_A0876	1.276e-146	471.0	COG2255@1|root,COG2255@2|Bacteria,3J0AU@40117|Nitrospirae	40117|Nitrospirae	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
REGS1_k127_4843622_1	443143.GM18_3434	1.156e-54	198.0	COG1636@1|root,COG1636@2|Bacteria,1MUG5@1224|Proteobacteria,42M1E@68525|delta/epsilon subdivisions,2WVRH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)	queH	-	1.17.99.6	ko:K09765	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF208
REGS1_k127_4846383_1	396588.Tgr7_2954	3.394e-06	49.0	COG4828@1|root,COG4828@2|Bacteria,1NPF1@1224|Proteobacteria,1SH6F@1236|Gammaproteobacteria,1X1YB@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function (DUF1622)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1622
REGS1_k127_4846383_0	555088.DealDRAFT_1209	0.0	1562.0	COG0458@1|root,COG0458@2|Bacteria,1TPID@1239|Firmicutes,24819@186801|Clostridia	1239|Firmicutes	F	Belongs to the CarB family	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
REGS1_k127_4877747_0	289376.THEYE_A1009	4.302e-264	830.0	COG0317@1|root,COG0317@2|Bacteria,3J0CX@40117|Nitrospirae	40117|Nitrospirae	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	-	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
REGS1_k127_4877747_1	289376.THEYE_A0278	1.638e-48	182.0	COG0608@1|root,COG0608@2|Bacteria,3J0PF@40117|Nitrospirae	40117|Nitrospirae	L	DHH family	recJ	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
REGS1_k127_4884083_1	555079.Toce_0687	7.093e-65	236.0	COG1477@1|root,COG1477@2|Bacteria,1TR9C@1239|Firmicutes,248KJ@186801|Clostridia,42FAD@68295|Thermoanaerobacterales	186801|Clostridia	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	apbE	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
REGS1_k127_4884083_0	1123376.AUIU01000014_gene578	6e-322	1007.0	COG0178@1|root,COG0178@2|Bacteria,3J0C7@40117|Nitrospirae	40117|Nitrospirae	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	-	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
REGS1_k127_4887440_1	1123373.ATXI01000005_gene900	7.048e-76	271.0	COG1208@1|root,COG3178@1|root,COG1208@2|Bacteria,COG3178@2|Bacteria,2GHXN@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	JM	Ecdysteroid kinase	-	-	2.7.1.221	ko:K07102	ko00520,ko01100,map00520,map01100	-	R08968,R11024	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	APH,NTP_transferase
REGS1_k127_4887440_0	289376.THEYE_A0955	1.394e-165	529.0	COG3876@1|root,COG3876@2|Bacteria	2|Bacteria	G	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF1343
REGS1_k127_4893999_1	1287276.X752_17805	4.33e-22	98.0	COG2081@1|root,COG2081@2|Bacteria,1MUGC@1224|Proteobacteria,2TTXA@28211|Alphaproteobacteria,43HGM@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	HI0933-like protein	yhiN	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K07007	-	-	-	-	ko00000	-	-	-	HI0933_like
REGS1_k127_4893999_0	290397.Adeh_2000	5.23e-27	121.0	COG0501@1|root,COG0501@2|Bacteria	2|Bacteria	O	metalloendopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48,Peptidase_M56
REGS1_k127_4895824_3	1110502.TMO_3540	6.047e-07	52.0	COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,2TRQN@28211|Alphaproteobacteria,2JR3D@204441|Rhodospirillales	204441|Rhodospirillales	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	HHH_5,KH_5,NusA_N,S1
REGS1_k127_4895824_0	748449.Halha_1207	3.955e-186	604.0	COG1200@1|root,COG1200@2|Bacteria,1TQ6I@1239|Firmicutes,247T0@186801|Clostridia,3WA9E@53433|Halanaerobiales	186801|Clostridia	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
REGS1_k127_4895824_1	243231.GSU2043	1.4e-81	278.0	COG1989@1|root,COG1989@2|Bacteria,1MUZF@1224|Proteobacteria,42S2A@68525|delta/epsilon subdivisions,2WMQ8@28221|Deltaproteobacteria,43TK2@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue	pilD	-	3.4.23.43	ko:K02654	-	M00331	-	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2	-	-	DiS_P_DiS,Peptidase_A24
REGS1_k127_4911987_7	656519.Halsa_0405	0.0002544	44.0	COG0355@1|root,COG0355@2|Bacteria,1VA89@1239|Firmicutes,24ND7@186801|Clostridia,3WATC@53433|Halanaerobiales	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	iHN637.CLJU_RS01195	ATP-synt_DE,ATP-synt_DE_N
REGS1_k127_4911987_0	269799.Gmet_1245	3.251e-140	467.0	COG4206@1|root,COG4206@2|Bacteria,1MW63@1224|Proteobacteria,42PQU@68525|delta/epsilon subdivisions,2WM3U@28221|Deltaproteobacteria,43W44@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	TonB dependent receptor	-	-	-	ko:K16092	-	-	-	-	ko00000,ko02000	1.B.14.3	-	-	Plug,TonB_dep_Rec
REGS1_k127_4911987_1	933262.AXAM01000017_gene3115	2.395e-122	408.0	COG0641@1|root,COG0641@2|Bacteria,1QJ1D@1224|Proteobacteria,4376M@68525|delta/epsilon subdivisions,2X26M@28221|Deltaproteobacteria,2MNYP@213118|Desulfobacterales	28221|Deltaproteobacteria	C	radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_4911987_4	243231.GSU1444	1.9e-61	222.0	COG2984@1|root,COG2984@2|Bacteria,1Q1HH@1224|Proteobacteria,42UE1@68525|delta/epsilon subdivisions,2WR33@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
REGS1_k127_4911987_3	269799.Gmet_1243	2.131e-111	378.0	COG0745@1|root,COG4191@1|root,COG0745@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria,43VZ7@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Domains HAMP, HisKA, HATPase_c, REC	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	GAF,HAMP,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,PocR,Response_reg,sCache_2
REGS1_k127_4911987_2	589865.DaAHT2_0647	2.593e-118	394.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2MIB8@213118|Desulfobacterales	28221|Deltaproteobacteria	T	response regulator receiver	-	-	-	ko:K02481,ko:K07712	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
REGS1_k127_4911987_6	1304872.JAGC01000005_gene2081	1.204e-16	82.0	COG2197@1|root,COG2197@2|Bacteria,1PTWI@1224|Proteobacteria,436RK@68525|delta/epsilon subdivisions,2X1EM@28221|Deltaproteobacteria,2MEW7@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	Autoinducer binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Autoind_bind,GerE
REGS1_k127_4911987_5	1121448.DGI_3363	1.491e-47	184.0	COG2159@1|root,COG2159@2|Bacteria,1R7E1@1224|Proteobacteria,42NK6@68525|delta/epsilon subdivisions,2WR4B@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
REGS1_k127_4927261_0	1049564.TevJSym_ac00600	3.958e-134	447.0	COG1271@1|root,COG1271@2|Bacteria	2|Bacteria	C	aerobic electron transport chain	-	-	1.10.3.14	ko:K00425,ko:K08738	ko00190,ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00190,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00153,M00595	R10151,R11325	RC00061,RC03151,RC03152	ko00000,ko00001,ko00002,ko01000	3.D.4.3,3.D.4.6	-	-	Cyt_bd_oxida_I,Cytochrome_CBB3
REGS1_k127_4927261_1	247490.KSU1_B0267	5.145e-14	80.0	COG2010@1|root,COG2010@2|Bacteria,2IXPN@203682|Planctomycetes	203682|Planctomycetes	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
REGS1_k127_493408_5	289376.THEYE_A1762	1.301e-10	61.0	COG0019@1|root,COG0019@2|Bacteria	2|Bacteria	E	diaminopimelate decarboxylase activity	speC	-	4.1.1.17	ko:K01581	ko00330,ko00480,ko01100,ko01110,ko01130,map00330,map00480,map01100,map01110,map01130	M00134	R00670	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
REGS1_k127_493408_1	289376.THEYE_A1761	2.197e-128	415.0	COG0421@1|root,COG0421@2|Bacteria	2|Bacteria	E	spermidine synthase activity	speE	GO:0003674,GO:0003824,GO:0004766,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0016740,GO:0016765,GO:0034641,GO:0042401,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	AdoMet_dc,Spermine_synt_N,Spermine_synth
REGS1_k127_493408_2	289376.THEYE_A0186	1.159e-109	359.0	COG0682@1|root,COG0682@2|Bacteria,3J0G4@40117|Nitrospirae	40117|Nitrospirae	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
REGS1_k127_493408_3	289376.THEYE_A1760	3.062e-93	316.0	COG1420@1|root,COG1420@2|Bacteria,3J15C@40117|Nitrospirae	40117|Nitrospirae	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	-	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HrcA
REGS1_k127_493408_4	289376.THEYE_A1759	3.729e-38	151.0	COG0576@1|root,COG0576@2|Bacteria,3J0QP@40117|Nitrospirae	40117|Nitrospirae	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
REGS1_k127_493408_0	289376.THEYE_A1758	2.033e-320	987.0	COG0443@1|root,COG0443@2|Bacteria,3J0D2@40117|Nitrospirae	40117|Nitrospirae	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
REGS1_k127_4947967_1	667014.Thein_0586	1.441e-78	268.0	COG2191@1|root,COG2191@2|Bacteria,2GICJ@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	C	FmdE, Molybdenum formylmethanofuran dehydrogenase operon	-	-	1.2.7.12	ko:K11261	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060,R11743	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	FmdE
REGS1_k127_4947967_6	443143.GM18_4465	1.845e-26	115.0	COG2005@1|root,COG2005@2|Bacteria,1MZ31@1224|Proteobacteria,42NA0@68525|delta/epsilon subdivisions,2WRTB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	ko:K02019	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1
REGS1_k127_4947967_0	589865.DaAHT2_0550	5.862e-128	419.0	COG0303@1|root,COG0303@2|Bacteria,1QUKM@1224|Proteobacteria,42NTF@68525|delta/epsilon subdivisions,2X75Q@28221|Deltaproteobacteria,2MITK@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Probable molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	MoCF_biosynth
REGS1_k127_4947967_3	292459.STH802	3.813e-62	226.0	COG0559@1|root,COG0559@2|Bacteria,1TR24@1239|Firmicutes,2480A@186801|Clostridia	186801|Clostridia	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
REGS1_k127_4947967_4	649638.Trad_0573	5.186e-52	196.0	COG4177@1|root,COG4177@2|Bacteria,1WJ7X@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	branched-chain amino acid transport system, permease component	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
REGS1_k127_4947967_2	292459.STH800	5.349e-75	259.0	COG0411@1|root,COG0411@2|Bacteria,1TR0P@1239|Firmicutes,2490B@186801|Clostridia	186801|Clostridia	E	Abc transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
REGS1_k127_4947967_5	1089548.KI783301_gene2383	1.744e-44	165.0	COG0410@1|root,COG0410@2|Bacteria	2|Bacteria	E	branched-chain amino acid transmembrane transporter activity	livF	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
REGS1_k127_495930_2	1033739.CAEU01000041_gene809	2.584e-06	54.0	COG2608@1|root,COG2608@2|Bacteria,1VERB@1239|Firmicutes,4HNP0@91061|Bacilli,26G9W@186818|Planococcaceae	91061|Bacilli	P	Copper chaperone	copZ	-	-	ko:K07213	ko04978,map04978	-	-	-	ko00000,ko00001	-	-	-	HMA
REGS1_k127_495930_1	511051.CSE_09940	9.139e-28	119.0	COG0526@1|root,COG0526@2|Bacteria	2|Bacteria	CO	cell redox homeostasis	resA	-	-	ko:K02199	-	-	-	-	ko00000,ko03110	-	-	-	AhpC-TSA,Thioredoxin_8
REGS1_k127_495930_0	1173027.Mic7113_3377	3.012e-89	309.0	COG0745@1|root,COG2114@1|root,COG5002@1|root,COG0745@2|Bacteria,COG2114@2|Bacteria,COG5002@2|Bacteria,1GHFQ@1117|Cyanobacteria,1H9WN@1150|Oscillatoriales	1117|Cyanobacteria	T	7TM diverse intracellular signalling	-	-	-	ko:K19694	-	-	-	-	ko00000,ko01001,ko02022	-	-	-	7TMR-DISM_7TM,Guanylate_cyc,HAMP,HATPase_c,HisKA,PAS_9,Response_reg,dCache_1
REGS1_k127_4960556_4	575586.HMPREF0016_00598	4.934e-05	48.0	COG2852@1|root,COG2852@2|Bacteria,1N0QU@1224|Proteobacteria,1SAT7@1236|Gammaproteobacteria,3NNGV@468|Moraxellaceae	1236|Gammaproteobacteria	S	Protein of unknown function (DUF559)	-	-	-	-	-	-	-	-	-	-	-	-	DUF559
REGS1_k127_4960556_0	1499967.BAYZ01000076_gene837	8.374e-127	415.0	COG0123@1|root,COG0123@2|Bacteria,2NP8V@2323|unclassified Bacteria	2|Bacteria	BQ	Histone deacetylase domain	acuC	-	-	ko:K04768	-	-	-	-	ko00000	-	-	-	Hist_deacetyl
REGS1_k127_4960556_3	1217715.F994_01571	4.795e-09	66.0	COG2199@1|root,COG3706@2|Bacteria,1REBC@1224|Proteobacteria,1SQ27@1236|Gammaproteobacteria,3NK5S@468|Moraxellaceae	1236|Gammaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
REGS1_k127_4960556_2	289376.THEYE_A0985	2.966e-26	111.0	COG2920@1|root,COG2920@2|Bacteria	2|Bacteria	P	part of a sulfur-relay system	-	-	-	ko:K11179	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DsrC
REGS1_k127_4960556_1	927677.ALVU02000001_gene4655	6.711e-41	161.0	COG2334@1|root,COG2334@2|Bacteria,1G3HF@1117|Cyanobacteria,1H5CW@1142|Synechocystis	1117|Cyanobacteria	S	Ecdysteroid kinase	-	-	-	-	-	-	-	-	-	-	-	-	APH
REGS1_k127_4963615_2	289376.THEYE_A1109	8.646e-58	208.0	COG0491@1|root,COG0491@2|Bacteria,3J0VN@40117|Nitrospirae	40117|Nitrospirae	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
REGS1_k127_4963615_4	289376.THEYE_A0216	3.135e-22	103.0	2DU0J@1|root,32UW9@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_4963615_1	443144.GM21_2073	1.332e-71	250.0	COG2930@1|root,COG2930@2|Bacteria,1RHV6@1224|Proteobacteria,42TN0@68525|delta/epsilon subdivisions,2WQ75@28221|Deltaproteobacteria,43UMS@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Las17-binding protein actin regulator	-	-	-	-	-	-	-	-	-	-	-	-	Ysc84
REGS1_k127_4963615_0	909663.KI867150_gene2219	2.445e-77	266.0	COG0657@1|root,COG0657@2|Bacteria,1R74D@1224|Proteobacteria,4379T@68525|delta/epsilon subdivisions,2X2DS@28221|Deltaproteobacteria,2MSHY@213462|Syntrophobacterales	28221|Deltaproteobacteria	I	Protein of unknown function (DUF1460)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1460
REGS1_k127_4963615_3	909663.KI867150_gene2220	7.167e-25	105.0	COG2211@1|root,COG2211@2|Bacteria,1QTSE@1224|Proteobacteria,43C8U@68525|delta/epsilon subdivisions,2X7J6@28221|Deltaproteobacteria,2MSKV@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	Acetyl-coenzyme A transporter 1	-	-	-	ko:K08218	ko01501,map01501	M00628	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.25	-	-	MFS_1
REGS1_k127_4972780_0	156889.Mmc1_2110	2.324e-131	430.0	COG1453@1|root,COG1453@2|Bacteria,1RAU3@1224|Proteobacteria	1224|Proteobacteria	S	PFAM aldo keto reductase	-	-	-	ko:K07079	-	-	-	-	ko00000	-	-	-	Aldo_ket_red
REGS1_k127_4972780_4	886293.Sinac_4158	3.022e-21	94.0	2C51Y@1|root,33J3U@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_4972780_1	56780.SYN_02009	4.902e-53	192.0	COG2890@1|root,COG2890@2|Bacteria,1QUYS@1224|Proteobacteria,42UV8@68525|delta/epsilon subdivisions,2WQQU@28221|Deltaproteobacteria,2MRUR@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Tellurite resistance protein TehB	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
REGS1_k127_4972780_5	756067.MicvaDRAFT_0297	2.586e-11	66.0	COG2203@1|root,COG5001@1|root,COG2203@2|Bacteria,COG5001@2|Bacteria,1G0SY@1117|Cyanobacteria,1H7V4@1150|Oscillatoriales	1117|Cyanobacteria	T	signal transduction protein containing a membrane domain an EAL and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF_2,GGDEF,PAS_3,PAS_9
REGS1_k127_5045700_1	1232410.KI421415_gene3019	2.431e-52	190.0	COG1651@1|root,COG1651@2|Bacteria,1RD39@1224|Proteobacteria,42QRZ@68525|delta/epsilon subdivisions,2WMZS@28221|Deltaproteobacteria,43SGM@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process	-	-	5.3.4.1	ko:K03981	-	-	-	-	ko00000,ko01000,ko02044,ko03110	3.A.7.11.1	-	-	DsbC_N,Thioredoxin_2
REGS1_k127_5045700_0	608538.HTH_1652	3.424e-56	208.0	COG0438@1|root,COG0438@2|Bacteria,2G4RK@200783|Aquificae	200783|Aquificae	H	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4
REGS1_k127_5050831_3	1232410.KI421412_gene22	0.0002708	49.0	2EKQ7@1|root,33EDZ@2|Bacteria,1NHK0@1224|Proteobacteria,42WYF@68525|delta/epsilon subdivisions,2WSKJ@28221|Deltaproteobacteria,43VUS@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF2845)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2845
REGS1_k127_5050831_1	671143.DAMO_2539	1.168e-38	158.0	COG1276@1|root,COG2372@1|root,COG1276@2|Bacteria,COG2372@2|Bacteria,2NPS1@2323|unclassified Bacteria	2|Bacteria	P	Evidence 5 No homology to any previously reported sequences	-	-	-	ko:K07156,ko:K07245,ko:K14166	-	-	-	-	ko00000,ko02000	9.B.62.1,9.B.62.2	-	-	CopC,CopD
REGS1_k127_5050831_2	671143.DAMO_1907	6.283e-34	134.0	COG2372@1|root,COG2372@2|Bacteria	2|Bacteria	C	response to copper ion	-	-	-	ko:K07156,ko:K14166	-	-	-	-	ko00000,ko02000	9.B.62.2	-	-	CopC,CopD
REGS1_k127_5050831_0	1472716.KBK24_0134845	2.64e-72	250.0	28HTF@1|root,2Z80A@2|Bacteria,1PEXH@1224|Proteobacteria,2W3AU@28216|Betaproteobacteria,1K43D@119060|Burkholderiaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_506413_1	675635.Psed_3477	2.601e-56	205.0	COG1926@1|root,COG2312@1|root,COG1926@2|Bacteria,COG2312@2|Bacteria,2GJUU@201174|Actinobacteria,4EFE0@85010|Pseudonocardiales	201174|Actinobacteria	S	Erythromycin esterase	-	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K07100	-	-	-	-	ko00000	-	-	-	Erythro_esteras,Pribosyltran
REGS1_k127_506413_0	1123376.AUIU01000016_gene289	1.655e-58	205.0	COG0102@1|root,COG0102@2|Bacteria,3J0NE@40117|Nitrospirae	40117|Nitrospirae	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	-	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
REGS1_k127_506413_2	338963.Pcar_1899	1.979e-44	166.0	COG0103@1|root,COG0103@2|Bacteria,1RD4A@1224|Proteobacteria,42SVI@68525|delta/epsilon subdivisions,2WP7T@28221|Deltaproteobacteria,43SIQ@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Ribosomal protein S9/S16	rpsI	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
REGS1_k127_5078317_2	404380.Gbem_3372	1.134e-55	215.0	2EUXR@1|root,33ND1@2|Bacteria,1P0HH@1224|Proteobacteria,431FA@68525|delta/epsilon subdivisions,2WWMS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_5078317_4	314278.NB231_16078	4.643e-21	108.0	COG2010@1|root,COG2010@2|Bacteria,1N97E@1224|Proteobacteria,1SCE9@1236|Gammaproteobacteria,1WZFR@135613|Chromatiales	135613|Chromatiales	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	ko:K02305	ko00910,ko01120,map00910,map01120	M00529	R00294	RC02794	ko00000,ko00001,ko00002	3.D.4.10	-	-	Cytochrom_C
REGS1_k127_5078317_1	690850.Desaf_1548	5.057e-80	267.0	COG0432@1|root,COG0432@2|Bacteria,1RA5G@1224|Proteobacteria,42QZ8@68525|delta/epsilon subdivisions,2WMV9@28221|Deltaproteobacteria,2MB2S@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
REGS1_k127_5078317_5	1047013.AQSP01000122_gene2227	0.0003156	48.0	COG2197@1|root,COG2197@2|Bacteria	2|Bacteria	K	response regulator	-	-	-	ko:K02282,ko:K07705	ko02020,map02020	M00492	-	-	ko00000,ko00001,ko00002,ko02022,ko02035,ko02044	-	-	-	GerE,Response_reg,TauD
REGS1_k127_5078317_0	522772.Dacet_1803	9.828e-146	471.0	COG2230@1|root,COG2230@2|Bacteria,2GENQ@200930|Deferribacteres	200930|Deferribacteres	H	Mycolic acid cyclopropane synthetase	-	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
REGS1_k127_5082696_2	289376.THEYE_A1303	1.237e-15	77.0	COG1858@1|root,COG1858@2|Bacteria,3J0GH@40117|Nitrospirae	40117|Nitrospirae	C	Di-haem cytochrome c peroxidase	-	-	1.11.1.5	ko:K00428	-	-	-	-	ko00000,ko01000	-	-	-	CCP_MauG,Cytochrom_C
REGS1_k127_5082696_1	443143.GM18_2739	3.09e-154	501.0	COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,42PV9@68525|delta/epsilon subdivisions,2WKF2@28221|Deltaproteobacteria,43UX8@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	PLD-like domain	-	-	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2
REGS1_k127_5082696_0	1289135.A966_11576	1.385e-162	527.0	COG0111@1|root,COG0111@2|Bacteria,2J7TF@203691|Spirochaetes	203691|Spirochaetes	C	D-isomer specific 2-hydroxyacid dehydrogenase	serA	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
REGS1_k127_5096314_1	1232410.KI421420_gene3156	1.476e-108	374.0	COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,42MCT@68525|delta/epsilon subdivisions,2WINW@28221|Deltaproteobacteria,43T20@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell	glnE	-	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
REGS1_k127_5096314_0	880072.Desac_2878	2.599e-121	394.0	COG1173@1|root,COG1173@2|Bacteria,1MU26@1224|Proteobacteria,42MFP@68525|delta/epsilon subdivisions,2WJ47@28221|Deltaproteobacteria,2MQ6J@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
REGS1_k127_5100963_0	330214.NIDE3201	1.021e-13	75.0	2C4PS@1|root,2ZHNK@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_5106060_0	234267.Acid_7170	9.139e-176	558.0	COG1523@1|root,COG1523@2|Bacteria,3Y3YA@57723|Acidobacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 13 family	glgX	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
REGS1_k127_5106060_3	269799.Gmet_3132	6.733e-54	196.0	COG1392@1|root,COG1392@2|Bacteria,1R4SP@1224|Proteobacteria,42SPV@68525|delta/epsilon subdivisions,2WPTH@28221|Deltaproteobacteria,43SW8@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	Protein of unknown function DUF47	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
REGS1_k127_5106060_1	525904.Tter_0129	9.694e-123	401.0	COG0306@1|root,COG0306@2|Bacteria,2NP4R@2323|unclassified Bacteria	2|Bacteria	P	Phosphate transporter family	pit	GO:0003674,GO:0005215,GO:0005315,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0015291,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0035435,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
REGS1_k127_5106060_2	1158338.JNLJ01000001_gene320	1.289e-105	347.0	COG0133@1|root,COG0133@2|Bacteria,2G3PS@200783|Aquificae	200783|Aquificae	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	GO:0000162,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
REGS1_k127_5116983_6	641112.ACOK01000042_gene1671	2.185e-13	76.0	COG0663@1|root,COG4124@1|root,COG0663@2|Bacteria,COG4124@2|Bacteria,1UMGS@1239|Firmicutes,25GHN@186801|Clostridia	186801|Clostridia	G	Belongs to the glycosyl hydrolase 26 family	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_5116983_3	589865.DaAHT2_0654	3.49e-41	167.0	COG0642@1|root,COG2204@1|root,COG2204@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,Hpt,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
REGS1_k127_5116983_1	1499967.BAYZ01000022_gene231	8.143e-72	248.0	COG0778@1|root,COG0778@2|Bacteria,2NPP2@2323|unclassified Bacteria	2|Bacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
REGS1_k127_5116983_5	242619.PG_0982	1.848e-14	81.0	COG0457@1|root,COG0457@2|Bacteria,4NGGZ@976|Bacteroidetes,2FUXM@200643|Bacteroidia,22YRA@171551|Porphyromonadaceae	976|Bacteroidetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_2,TPR_8
REGS1_k127_5116983_0	1123376.AUIU01000014_gene703	7.068e-122	400.0	COG0533@1|root,COG0533@2|Bacteria,3J0I3@40117|Nitrospirae	40117|Nitrospirae	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
REGS1_k127_5116983_2	204669.Acid345_2866	3.379e-51	196.0	COG2203@1|root,COG2206@1|root,COG2203@2|Bacteria,COG2206@2|Bacteria,3Y52R@57723|Acidobacteria	57723|Acidobacteria	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_5116983_7	357808.RoseRS_3288	1.507e-09	63.0	COG1366@1|root,COG1366@2|Bacteria,2G9K5@200795|Chloroflexi,375MW@32061|Chloroflexia	32061|Chloroflexia	T	PFAM Sulfate transporter antisigma-factor antagonist STAS	-	-	-	-	-	-	-	-	-	-	-	-	STAS
REGS1_k127_5116983_4	487796.Flav2ADRAFT_1527	2.057e-15	81.0	COG2172@1|root,COG2172@2|Bacteria	2|Bacteria	T	sigma factor antagonist activity	-	-	2.7.11.1	ko:K04757	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	HATPase_c_2
REGS1_k127_5119149_3	671143.DAMO_0447	8.281e-31	125.0	COG1694@1|root,COG3956@2|Bacteria,2NP9V@2323|unclassified Bacteria	2|Bacteria	E	MazG nucleotide pyrophosphohydrolase domain	mazG	GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009147,GO:0009149,GO:0009151,GO:0009155,GO:0009164,GO:0009166,GO:0009199,GO:0009200,GO:0009203,GO:0009204,GO:0009208,GO:0009210,GO:0009211,GO:0009213,GO:0009215,GO:0009217,GO:0009218,GO:0009219,GO:0009222,GO:0009223,GO:0009259,GO:0009261,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046046,GO:0046047,GO:0046051,GO:0046052,GO:0046060,GO:0046061,GO:0046070,GO:0046075,GO:0046076,GO:0046080,GO:0046081,GO:0046131,GO:0046133,GO:0046135,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658	3.6.1.66,3.6.1.9	ko:K02428,ko:K02499,ko:K04765	ko00230,ko00240,ko00760,ko00770,ko01100,map00230,map00240,map00760,map00770,map01100	-	R00086,R00087,R00103,R00287,R00426,R00515,R00662,R00720,R01855,R02100,R02720,R03004,R03036,R03531,R11323	RC00002	ko00000,ko00001,ko01000,ko03036	-	-	iJN678.sll1005	MazG,TP_methylase
REGS1_k127_5119149_2	696281.Desru_1133	6.076e-92	315.0	COG0635@1|root,COG0635@2|Bacteria,1TPES@1239|Firmicutes,247P8@186801|Clostridia,260TE@186807|Peptococcaceae	186801|Clostridia	H	Involved in the biosynthesis of porphyrin-containing compound	hemN	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
REGS1_k127_5119149_0	443143.GM18_2340	1.493e-172	551.0	COG0477@1|root,COG0477@2|Bacteria,1QWM9@1224|Proteobacteria	1224|Proteobacteria	EGP	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
REGS1_k127_5119149_1	289376.THEYE_A1139	2.364e-115	383.0	COG1092@1|root,COG1092@2|Bacteria,3J0IV@40117|Nitrospirae	40117|Nitrospirae	J	S-adenosylmethionine-dependent methyltransferase	-	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
REGS1_k127_5143944_2	289376.THEYE_A2099	3.151e-159	521.0	COG0751@1|root,COG0751@2|Bacteria,3J0F0@40117|Nitrospirae	40117|Nitrospirae	J	Glycyl-tRNA synthetase beta subunit	glyS	-	6.1.1.14	ko:K01879	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_1,tRNA_synt_2f
REGS1_k127_5143944_3	768670.Calni_0744	8.168e-146	467.0	COG0752@1|root,COG0752@2|Bacteria,2GEZ4@200930|Deferribacteres	200930|Deferribacteres	J	Glycyl-tRNA synthetase alpha subunit	glyQ	-	6.1.1.14	ko:K01878	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2e
REGS1_k127_5143944_4	289376.THEYE_A1971	2.198e-141	457.0	COG0674@1|root,COG0674@2|Bacteria	2|Bacteria	C	oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor	vorA	-	1.2.7.11,1.2.7.3,1.2.7.7	ko:K00174,ko:K00186	ko00010,ko00020,ko00280,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00280,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197,R07160,R08566,R08567	RC00004,RC02742,RC02833,RC02856	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1307	PFOR_II,POR_N
REGS1_k127_5143944_5	909663.KI867150_gene448	2.062e-66	231.0	COG2110@1|root,COG2110@2|Bacteria,1RCWP@1224|Proteobacteria,42RVP@68525|delta/epsilon subdivisions,2WNCX@28221|Deltaproteobacteria,2MQI0@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Appr-1'-p processing enzyme	ymdB	-	-	-	-	-	-	-	-	-	-	-	Macro
REGS1_k127_5143944_0	338963.Pcar_2043	8.89e-192	614.0	COG2262@1|root,COG2262@2|Bacteria,1MUA0@1224|Proteobacteria,42NA6@68525|delta/epsilon subdivisions,2WIMU@28221|Deltaproteobacteria,43SCK@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	GTP-binding GTPase Middle Region	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
REGS1_k127_5143944_1	589865.DaAHT2_1941	3.299e-173	546.0	COG0535@1|root,COG0535@2|Bacteria,1MUQP@1224|Proteobacteria,42M55@68525|delta/epsilon subdivisions,2WIKM@28221|Deltaproteobacteria,2MJ60@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Radical SAM domain protein	-	-	-	ko:K22227	-	-	-	-	ko00000	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
REGS1_k127_5145890_1	1232683.ADIMK_4078	2.233e-05	56.0	COG3391@1|root,COG3391@2|Bacteria,1P862@1224|Proteobacteria,1RQZK@1236|Gammaproteobacteria,465NT@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	40-residue YVTN family beta-propeller repeat	pedA	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_D1,Lactonase
REGS1_k127_5145890_0	1128398.Curi_c19960	1.321e-18	89.0	COG0577@1|root,COG0577@2|Bacteria,1UYZ9@1239|Firmicutes,2484S@186801|Clostridia,26A4A@186813|unclassified Clostridiales	186801|Clostridia	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
REGS1_k127_5161483_2	234267.Acid_0907	3.577e-10	60.0	COG0103@1|root,COG0103@2|Bacteria,3Y4IK@57723|Acidobacteria	57723|Acidobacteria	J	Belongs to the universal ribosomal protein uS9 family	rpsI	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
REGS1_k127_5161483_0	289376.THEYE_A1580	1.137e-132	431.0	COG0002@1|root,COG0002@2|Bacteria,3J0H9@40117|Nitrospirae	40117|Nitrospirae	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	-	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
REGS1_k127_5161483_1	1123376.AUIU01000011_gene1133	3.054e-124	409.0	COG1364@1|root,COG1364@2|Bacteria,3J0B5@40117|Nitrospirae	40117|Nitrospirae	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	argJ	-	2.3.1.1,2.3.1.35	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgJ
REGS1_k127_5185570_4	439235.Dalk_3656	2.598e-147	499.0	COG0591@1|root,COG3852@1|root,COG0591@2|Bacteria,COG3852@2|Bacteria,1NTTH@1224|Proteobacteria,43CEX@68525|delta/epsilon subdivisions,2X7PW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	SMART PAS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HisKA,PAS
REGS1_k127_5185570_3	289376.THEYE_A0039	1.415e-149	486.0	COG2204@1|root,COG2204@2|Bacteria,3J10B@40117|Nitrospirae	40117|Nitrospirae	T	Sigma-54 interaction domain	-	-	-	ko:K07714	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
REGS1_k127_5185570_1	289376.THEYE_A0033	1.478e-255	803.0	COG2905@1|root,COG2905@2|Bacteria,3J0UW@40117|Nitrospirae	40117|Nitrospirae	T	Domain in cystathionine beta-synthase and other proteins.	-	-	-	ko:K07182	-	-	-	-	ko00000	-	-	-	CBS,DUF294,DUF294_C,cNMP_binding
REGS1_k127_5185570_5	289376.THEYE_A0037	1.532e-36	147.0	COG0847@1|root,COG0847@2|Bacteria	2|Bacteria	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease	dnaQ	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
REGS1_k127_5185570_6	1123376.AUIU01000013_gene1775	6.681e-29	118.0	COG3162@1|root,COG3162@2|Bacteria	2|Bacteria	S	Protein of unknown function, DUF485	yjcH	-	-	-	-	-	-	-	-	-	-	-	DUF485
REGS1_k127_5185570_2	404589.Anae109_3836	2.564e-195	625.0	COG4147@1|root,COG4147@2|Bacteria,1MVJ8@1224|Proteobacteria,42MJE@68525|delta/epsilon subdivisions,2WK5T@28221|Deltaproteobacteria,2YWIX@29|Myxococcales	28221|Deltaproteobacteria	S	Sodium:solute symporter family	aplA	-	-	ko:K14393	-	-	-	-	ko00000,ko02000	2.A.21.7	-	iAF987.Gmet_0739	SSF
REGS1_k127_5185570_0	289376.THEYE_A0029	1.149e-276	856.0	COG0365@1|root,COG0365@2|Bacteria,3J0BJ@40117|Nitrospirae	40117|Nitrospirae	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
REGS1_k127_5205492_2	1123242.JH636435_gene1763	8.839e-43	162.0	2DM5T@1|root,31U0Y@2|Bacteria,2J16S@203682|Planctomycetes	203682|Planctomycetes	S	Domain of unknown function (DUF4126)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4126
REGS1_k127_5205492_3	1166018.FAES_5086	2.72e-24	106.0	COG3016@1|root,COG3016@2|Bacteria,4NEQ4@976|Bacteroidetes,47MCF@768503|Cytophagia	976|Bacteroidetes	S	Haem-binding uptake, Tiki superfamily, ChaN	-	-	-	-	-	-	-	-	-	-	-	-	Cofac_haem_bdg
REGS1_k127_5205492_0	247490.KSU1_C1622	8.878e-203	644.0	COG1730@1|root,COG1730@2|Bacteria	2|Bacteria	O	sister chromatid segregation	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,Multi-haem_cyto
REGS1_k127_5205492_1	909663.KI867150_gene1859	8.568e-198	623.0	COG0426@1|root,COG0426@2|Bacteria,1NDXY@1224|Proteobacteria,42N11@68525|delta/epsilon subdivisions,2WJ8Z@28221|Deltaproteobacteria,2MQWF@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Metallo-beta-lactamase superfamily	roo	-	1.6.3.4	ko:K22405	-	-	-	-	ko00000,ko01000	-	-	-	Flavodoxin_1,Lactamase_B
REGS1_k127_5273299_2	521460.Athe_0060	1.429e-81	280.0	COG1091@1|root,COG1091@2|Bacteria,1TP71@1239|Firmicutes,247PG@186801|Clostridia,42G83@68295|Thermoanaerobacterales	186801|Clostridia	C	Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose	rfbD	-	1.1.1.133	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000	-	-	-	RmlD_sub_bind
REGS1_k127_5273299_4	1121422.AUMW01000016_gene2059	1.153e-20	99.0	COG1434@1|root,COG1434@2|Bacteria,1VB45@1239|Firmicutes,24RV0@186801|Clostridia,262UT@186807|Peptococcaceae	186801|Clostridia	S	DUF218 domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF218
REGS1_k127_5273299_3	1123376.AUIU01000011_gene848	5.58e-27	112.0	COG0776@1|root,COG0776@2|Bacteria,3J19J@40117|Nitrospirae	40117|Nitrospirae	L	bacterial (prokaryotic) histone like domain	-	-	-	ko:K05788	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
REGS1_k127_5273299_1	289376.THEYE_A1771	1.461e-93	317.0	COG0616@1|root,COG0616@2|Bacteria,3J0J0@40117|Nitrospirae	40117|Nitrospirae	OU	Peptidase family S49	-	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
REGS1_k127_5273299_0	330214.NIDE0426	4.883e-153	493.0	COG0539@1|root,COG1185@1|root,COG0539@2|Bacteria,COG1185@2|Bacteria,3J0CA@40117|Nitrospirae	40117|Nitrospirae	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	-	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
REGS1_k127_5302768_5	1123376.AUIU01000011_gene850	1.129e-29	122.0	COG0539@1|root,COG0539@2|Bacteria,3J0CA@40117|Nitrospirae	40117|Nitrospirae	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	-	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
REGS1_k127_5302768_2	289376.THEYE_A1769	9.115e-96	321.0	COG0761@1|root,COG0761@2|Bacteria,3J0PP@40117|Nitrospirae	40117|Nitrospirae	IM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	-	LYTB
REGS1_k127_5302768_4	1123376.AUIU01000011_gene852	1.883e-52	194.0	COG0283@1|root,COG0283@2|Bacteria,3J0MY@40117|Nitrospirae	40117|Nitrospirae	F	Belongs to the cytidylate kinase family. Type 1 subfamily	cmk	GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin
REGS1_k127_5302768_0	398767.Glov_2148	1.952e-143	466.0	COG0128@1|root,COG0128@2|Bacteria,1MWMK@1224|Proteobacteria,42N01@68525|delta/epsilon subdivisions,2WKJQ@28221|Deltaproteobacteria,43TXZ@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
REGS1_k127_5302768_3	289376.THEYE_A1766	3.68e-78	270.0	COG0287@1|root,COG0287@2|Bacteria,3J0SQ@40117|Nitrospirae	40117|Nitrospirae	C	Prephenate dehydrogenase	-	-	1.3.1.12	ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025	R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	PDH
REGS1_k127_5302768_1	289376.THEYE_A1765	2.842e-110	359.0	COG2876@1|root,COG2876@2|Bacteria,3J0A5@40117|Nitrospirae	40117|Nitrospirae	E	NeuB family	-	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
REGS1_k127_5326044_4	1121422.AUMW01000027_gene420	7.92e-60	209.0	COG2258@1|root,COG2258@2|Bacteria,1V6DS@1239|Firmicutes,24HBA@186801|Clostridia,261U0@186807|Peptococcaceae	186801|Clostridia	S	PFAM MOSC domain	-	-	-	-	-	-	-	-	-	-	-	-	MOSC,MoCF_biosynth
REGS1_k127_5326044_3	289376.THEYE_A1202	2.221e-61	215.0	COG0521@1|root,COG0521@2|Bacteria,3J194@40117|Nitrospirae	40117|Nitrospirae	H	Probable molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	MoCF_biosynth
REGS1_k127_5326044_2	330214.NIDE0851	6.333e-66	237.0	COG0785@1|root,COG0785@2|Bacteria,3J0KU@40117|Nitrospirae	40117|Nitrospirae	O	Cytochrome C biogenesis protein transmembrane region	ccdA	-	-	ko:K06196	-	-	-	-	ko00000,ko02000	5.A.1.2	-	-	DsbD
REGS1_k127_5326044_5	765952.PUV_26370	1.572e-33	132.0	2E3V1@1|root,32YSA@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_5326044_1	1254432.SCE1572_09230	1.834e-92	309.0	COG0745@1|root,COG0745@2|Bacteria,1MWZ5@1224|Proteobacteria,42QTM@68525|delta/epsilon subdivisions,2WN5R@28221|Deltaproteobacteria,2YXCH@29|Myxococcales	28221|Deltaproteobacteria	K	Transcriptional regulatory protein, C terminal	kdpE	-	-	ko:K07667	ko02020,ko02024,map02020,map02024	M00454	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
REGS1_k127_5326044_0	671143.DAMO_0414	7.998e-314	984.0	COG0642@1|root,COG2205@2|Bacteria,2NNNV@2323|unclassified Bacteria	2|Bacteria	T	Osmosensitive K+ channel His kinase sensor domain	-	-	2.7.13.3	ko:K07646	ko02020,map02020	M00454	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF4118,HATPase_c,HisKA,KdpD,Usp
REGS1_k127_5354035_0	289376.THEYE_A1762	1.622e-131	428.0	COG0019@1|root,COG0019@2|Bacteria	2|Bacteria	E	diaminopimelate decarboxylase activity	speC	-	4.1.1.17	ko:K01581	ko00330,ko00480,ko01100,ko01110,ko01130,map00330,map00480,map01100,map01110,map01130	M00134	R00670	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
REGS1_k127_5354035_1	247490.KSU1_C0802	4.545e-50	181.0	COG1569@1|root,COG1569@2|Bacteria	2|Bacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN_3
REGS1_k127_5372223_5	443143.GM18_4434	7.851e-22	95.0	COG0755@1|root,COG0755@2|Bacteria	2|Bacteria	O	cytochrome complex assembly	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
REGS1_k127_5372223_2	243231.GSU3625	4.881e-47	181.0	COG1333@1|root,COG1333@2|Bacteria,1RIJF@1224|Proteobacteria,42T2N@68525|delta/epsilon subdivisions,2WPA1@28221|Deltaproteobacteria,43VTI@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	cytochrome c biogenesis protein	-	-	-	-	-	-	-	-	-	-	-	-	ResB
REGS1_k127_5372223_1	289376.THEYE_A0546	4.432e-56	198.0	COG1793@1|root,COG1793@2|Bacteria	2|Bacteria	L	dna ligase	ligD	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
REGS1_k127_5372223_3	1192034.CAP_7471	1.898e-45	173.0	COG0457@1|root,COG0457@2|Bacteria,1N5BD@1224|Proteobacteria,42U63@68525|delta/epsilon subdivisions,2WQUR@28221|Deltaproteobacteria,2YUQA@29|Myxococcales	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_11,TPR_16,TPR_19,TPR_2,TPR_4,TPR_8
REGS1_k127_5372223_0	1304880.JAGB01000003_gene1333	3.522e-114	376.0	COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,247NN@186801|Clostridia	186801|Clostridia	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031,ko:K02032,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
REGS1_k127_5372223_4	1395513.P343_18030	4.313e-36	143.0	COG4608@1|root,COG4608@2|Bacteria,1V36J@1239|Firmicutes,4H9YB@91061|Bacilli,26NGG@186821|Sporolactobacillaceae	91061|Bacilli	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
REGS1_k127_5379078_6	56780.SYN_02012	1.424e-15	77.0	COG0389@1|root,COG0389@2|Bacteria,1MUUH@1224|Proteobacteria,42NGG@68525|delta/epsilon subdivisions,2WIVT@28221|Deltaproteobacteria,2MQEQ@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
REGS1_k127_5379078_3	289376.THEYE_A2090	1.663e-87	296.0	COG1694@1|root,COG3956@2|Bacteria,3J0Q7@40117|Nitrospirae	40117|Nitrospirae	S	MazG nucleotide pyrophosphohydrolase domain	-	-	-	ko:K02499	-	-	-	-	ko00000,ko03036	-	-	-	MazG
REGS1_k127_5379078_2	635013.TherJR_2454	3.322e-89	306.0	COG0635@1|root,COG0635@2|Bacteria,1TPES@1239|Firmicutes,247P8@186801|Clostridia,260TE@186807|Peptococcaceae	186801|Clostridia	H	Involved in the biosynthesis of porphyrin-containing compound	hemN	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
REGS1_k127_5379078_4	1121472.AQWN01000008_gene1879	4.164e-86	288.0	COG0655@1|root,COG0655@2|Bacteria,1TT84@1239|Firmicutes,248W0@186801|Clostridia,261MC@186807|Peptococcaceae	186801|Clostridia	S	PFAM NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
REGS1_k127_5379078_5	626887.J057_08826	2.811e-44	167.0	COG1678@1|root,COG1678@2|Bacteria,1RCXM@1224|Proteobacteria,1S3YV@1236|Gammaproteobacteria,466MP@72275|Alteromonadaceae	1236|Gammaproteobacteria	K	Belongs to the UPF0301 (AlgH) family	yqgE	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K07735	-	-	-	-	ko00000,ko03000	-	-	-	DUF179
REGS1_k127_5379078_1	795359.TOPB45_0290	3.437e-110	361.0	COG0207@1|root,COG0207@2|Bacteria	2|Bacteria	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis	-	-	2.1.1.45	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylat_synt
REGS1_k127_5379078_0	289376.THEYE_A0654	0.0	1137.0	COG0060@1|root,COG0060@2|Bacteria,3J0BF@40117|Nitrospirae	40117|Nitrospirae	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
REGS1_k127_5395210_1	289376.THEYE_A0100	3.344e-75	263.0	COG1940@1|root,COG1940@2|Bacteria	2|Bacteria	GK	ROK family	-	-	2.7.1.188,2.7.1.2,2.7.1.214,2.7.1.60,5.1.3.9	ko:K00845,ko:K13967,ko:K19979,ko:K20433	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko00525,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map00525,map01100,map01110,map01120,map01130,map01200	M00001,M00549,M00814,M00815	R00299,R01600,R01786,R02087,R02705,R11185,R11234	RC00002,RC00017,RC00290	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
REGS1_k127_5395210_0	289376.THEYE_A0099	6.71e-283	878.0	COG0481@1|root,COG0481@2|Bacteria,3J0D1@40117|Nitrospirae	40117|Nitrospirae	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C
REGS1_k127_5395210_2	398767.Glov_1621	2.553e-55	198.0	COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,42NJE@68525|delta/epsilon subdivisions,2WKMA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	U	Belongs to the peptidase S26 family	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
REGS1_k127_542212_3	404380.Gbem_0999	9.073e-53	194.0	COG0671@1|root,COG0818@1|root,COG0671@2|Bacteria,COG0818@2|Bacteria,1Q5TS@1224|Proteobacteria,42SZA@68525|delta/epsilon subdivisions,2WPDT@28221|Deltaproteobacteria,43T24@69541|Desulfuromonadales	28221|Deltaproteobacteria	IM	Prokaryotic diacylglycerol kinase	-	-	2.7.1.107	ko:K00901	ko00561,ko00564,ko01100,ko01110,ko04070,ko04072,ko05231,map00561,map00564,map01100,map01110,map04070,map04072,map05231	-	R02240	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_2369	DAGK_prokar,PAP2
REGS1_k127_542212_4	986075.CathTA2_1810	8.442e-22	101.0	COG0319@1|root,COG0319@2|Bacteria,1V6BU@1239|Firmicutes,4HIIE@91061|Bacilli	91061|Bacilli	S	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA	ybeY	-	-	ko:K07042	-	-	-	-	ko00000,ko03009	-	-	-	UPF0054
REGS1_k127_542212_0	289376.THEYE_A0869	3.767e-149	487.0	COG1480@1|root,COG1480@2|Bacteria,3J11A@40117|Nitrospirae	40117|Nitrospirae	S	7TM receptor with intracellular HD hydrolase	-	-	-	ko:K07037	-	-	-	-	ko00000	-	-	-	7TM-7TMR_HD,HD
REGS1_k127_542212_1	330214.NIDE4089	8.115e-118	387.0	COG1702@1|root,COG1702@2|Bacteria,3J0AD@40117|Nitrospirae	40117|Nitrospirae	T	PhoH-like protein	-	-	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
REGS1_k127_542212_5	1265502.KB905929_gene2277	5.988e-05	53.0	COG3147@1|root,COG3147@2|Bacteria,1R7IV@1224|Proteobacteria,2VPE1@28216|Betaproteobacteria,4AC9S@80864|Comamonadaceae	28216|Betaproteobacteria	D	PFAM Sporulation domain protein	dedD	-	-	ko:K03749	-	-	-	-	ko00000	-	-	-	SPOR
REGS1_k127_542212_2	289376.THEYE_A0872	1.248e-93	316.0	COG0809@1|root,COG0809@2|Bacteria,3J0HB@40117|Nitrospirae	40117|Nitrospirae	J	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	queA	GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
REGS1_k127_5468767_0	289376.THEYE_A1002	4.126e-245	777.0	COG1449@1|root,COG1449@2|Bacteria,3J0AQ@40117|Nitrospirae	40117|Nitrospirae	G	Glycosyl hydrolase family 57	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_57
REGS1_k127_5468767_2	289376.THEYE_A1003	1.611e-16	83.0	COG2919@1|root,COG2919@2|Bacteria	2|Bacteria	D	cell cycle	divIC	-	-	ko:K05589,ko:K12065,ko:K13052	-	-	-	-	ko00000,ko02044,ko03036	3.A.7.11.1	-	-	DivIC
REGS1_k127_5468767_1	1123376.AUIU01000014_gene634	8.448e-189	598.0	COG0148@1|root,COG0148@2|Bacteria,3J0DB@40117|Nitrospirae	40117|Nitrospirae	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
REGS1_k127_5468767_3	1242864.D187_003259	0.0005251	48.0	2BS7F@1|root,32M8R@2|Bacteria,1Q33Y@1224|Proteobacteria,433XP@68525|delta/epsilon subdivisions,2X2HG@28221|Deltaproteobacteria,2YXTX@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_5481314_2	1165841.SULAR_02873	3.676e-12	71.0	2EG21@1|root,339U1@2|Bacteria,1P2NF@1224|Proteobacteria,42X8D@68525|delta/epsilon subdivisions,2YQRR@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	Protein required for attachment to host cells	-	-	-	-	-	-	-	-	-	-	-	-	Host_attach
REGS1_k127_5481314_0	243231.GSU2292	1.853e-151	487.0	COG0686@1|root,COG0686@2|Bacteria,1QTX1@1224|Proteobacteria,42MSF@68525|delta/epsilon subdivisions,2WKJ5@28221|Deltaproteobacteria,43T2M@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Belongs to the AlaDH PNT family	ald	-	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_1099	AlaDh_PNT_C,AlaDh_PNT_N
REGS1_k127_5481314_1	289376.THEYE_A1039	9.226e-59	218.0	COG3170@1|root,COG3170@2|Bacteria,3J1DA@40117|Nitrospirae	40117|Nitrospirae	NU	Protein of unknown function (DUF3108)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3108
REGS1_k127_5484674_1	1449126.JQKL01000047_gene2736	2.766e-60	218.0	COG0842@1|root,COG0842@2|Bacteria,1UYEB@1239|Firmicutes,24BUQ@186801|Clostridia	186801|Clostridia	V	Transport permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
REGS1_k127_5484674_0	1382306.JNIM01000001_gene660	1.815e-108	361.0	COG1131@1|root,COG1131@2|Bacteria,2G5RD@200795|Chloroflexi	200795|Chloroflexi	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
REGS1_k127_5491160_3	1123376.AUIU01000018_gene7	3.367e-18	87.0	COG0298@1|root,COG0298@2|Bacteria	2|Bacteria	O	carbon dioxide binding	hypC	-	-	ko:K04653	-	-	-	-	ko00000	-	-	iHN637.CLJU_RS11355	HupF_HypC
REGS1_k127_5491160_1	1123376.AUIU01000018_gene4	3.762e-76	259.0	COG0717@1|root,COG0717@2|Bacteria	2|Bacteria	F	dUTP biosynthetic process	dcd	GO:0003674,GO:0003824,GO:0006139,GO:0006220,GO:0006244,GO:0006253,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008829,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009166,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009223,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046065,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	dUTPase
REGS1_k127_5491160_2	1232410.KI421428_gene1213	1.382e-60	219.0	COG0284@1|root,COG0284@2|Bacteria,1MW2C@1224|Proteobacteria,42N5N@68525|delta/epsilon subdivisions,2WMJ5@28221|Deltaproteobacteria,43S93@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Orotidine 5'-phosphate decarboxylase / HUMPS family	pyrF	GO:0003674,GO:0003824,GO:0004590,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
REGS1_k127_5491160_0	574087.Acear_2309	1.013e-121	407.0	COG0147@1|root,COG0147@2|Bacteria,1TQAP@1239|Firmicutes,24946@186801|Clostridia,3WBGE@53433|Halanaerobiales	186801|Clostridia	EH	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	pabB	-	2.6.1.85,4.1.3.27,4.1.3.38	ko:K01657,ko:K01665,ko:K03342,ko:K13950	ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986,R01716,R05553	RC00010,RC01418,RC01843,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Anth_synt_I_N,Chorismate_bind,GATase
REGS1_k127_5547572_2	404589.Anae109_3758	2.082e-96	317.0	COG1100@1|root,COG1100@2|Bacteria,1R6NS@1224|Proteobacteria,42NIX@68525|delta/epsilon subdivisions,2WJ44@28221|Deltaproteobacteria,2YU2F@29|Myxococcales	28221|Deltaproteobacteria	S	ADP-ribosylation factor family	mglA	GO:0008150,GO:0032879,GO:0032880,GO:0050789,GO:0065007	-	ko:K06883	-	-	-	-	ko00000	-	-	-	Arf,Ras
REGS1_k127_5547572_4	269799.Gmet_3418	6.552e-61	214.0	COG2018@1|root,COG2018@2|Bacteria,1RDN5@1224|Proteobacteria,42S13@68525|delta/epsilon subdivisions,2WNKB@28221|Deltaproteobacteria,43T83@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	PFAM Roadblock LC7 family protein	mglB	-	-	-	-	-	-	-	-	-	-	-	Robl_LC7
REGS1_k127_5547572_1	903818.KI912268_gene798	1.06e-155	495.0	COG1013@1|root,COG1013@2|Bacteria	2|Bacteria	C	oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor	porB	-	1.2.7.1	ko:K00170	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iLJ478.TM0018	TPP_enzyme_C
REGS1_k127_5547572_0	289376.THEYE_A0909	8.056e-196	616.0	COG0674@1|root,COG0674@2|Bacteria,3J0HY@40117|Nitrospirae	40117|Nitrospirae	C	Pyruvate:ferredoxin oxidoreductase core domain II	-	-	1.2.7.1	ko:K00169	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
REGS1_k127_5547572_7	289376.THEYE_A0908	1.641e-49	177.0	COG1144@1|root,COG1144@2|Bacteria	2|Bacteria	C	oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor	porD	-	1.2.7.1	ko:K00171,ko:K00172	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_21
REGS1_k127_5547572_3	1123376.AUIU01000014_gene654	3.33e-94	312.0	COG1014@1|root,COG1014@2|Bacteria,3J0TG@40117|Nitrospirae	40117|Nitrospirae	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	-	-	1.2.7.1	ko:K00172	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
REGS1_k127_5547572_5	1123376.AUIU01000013_gene1756	2.197e-60	220.0	COG1561@1|root,COG1561@2|Bacteria,3J0QJ@40117|Nitrospirae	40117|Nitrospirae	S	Domain of unknown function (DUF1732)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1732,YicC_N
REGS1_k127_5547572_9	381764.Fnod_1678	1.805e-26	111.0	COG2052@1|root,COG2052@2|Bacteria,2GD5V@200918|Thermotogae	200918|Thermotogae	S	Belongs to the UPF0296 family	-	-	-	ko:K09777	-	-	-	-	ko00000	-	-	-	DUF370
REGS1_k127_5547572_6	868864.Dester_0178	3.997e-51	190.0	COG0194@1|root,COG0194@2|Bacteria,2G3ZQ@200783|Aquificae	200783|Aquificae	F	Essential for recycling GMP and indirectly, cGMP	gmk	-	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
REGS1_k127_5547572_8	289376.THEYE_A0403	4.272e-27	115.0	COG1758@1|root,COG1758@2|Bacteria,3J0UJ@40117|Nitrospirae	40117|Nitrospirae	K	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits	rpoZ	-	2.7.7.6	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
REGS1_k127_5547572_10	1134474.O59_000632	5.922e-15	77.0	COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,1RMKQ@1236|Gammaproteobacteria,1FFUM@10|Cellvibrio	1236|Gammaproteobacteria	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	GO:0000166,GO:0003674,GO:0003824,GO:0004632,GO:0004633,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0010181,GO:0015936,GO:0015937,GO:0016829,GO:0016830,GO:0016831,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032553,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	iEC042_1314.EC042_3945,iECUMN_1333.ECUMN_4154,iJN746.PP_5285,iSBO_1134.SBO_3641	DFP,Flavoprotein
REGS1_k127_5550166_1	378806.STAUR_1844	3.559e-135	446.0	COG2374@1|root,COG5492@1|root,COG2374@2|Bacteria,COG5492@2|Bacteria,1PZBJ@1224|Proteobacteria,42UE8@68525|delta/epsilon subdivisions,2WVIZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	N	Bacterial Ig-like domain 2	-	-	-	-	-	-	-	-	-	-	-	-	Big_2
REGS1_k127_5550166_2	118005.AWNK01000007_gene739	5.438e-53	201.0	COG2885@1|root,COG3047@1|root,COG2885@2|Bacteria,COG3047@2|Bacteria	2|Bacteria	M	chlorophyll binding	oprF	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944	-	ko:K03286,ko:K07275	-	-	-	-	ko00000,ko02000	1.B.6	-	-	OMP_b-brl,OmpA,OprF
REGS1_k127_5550166_3	99598.Cal7507_1772	6.726e-28	130.0	COG2931@1|root,COG3210@1|root,COG2931@2|Bacteria,COG3210@2|Bacteria,1GIZT@1117|Cyanobacteria,1HMI7@1161|Nostocales	1117|Cyanobacteria	Q	Haemolysin-type calcium-binding repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind,VCBS
REGS1_k127_5550166_0	909663.KI867150_gene1671	2.467e-137	452.0	COG0784@1|root,COG4191@1|root,COG5002@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,COG5002@2|Bacteria,1RCM9@1224|Proteobacteria,42N46@68525|delta/epsilon subdivisions,2WJT4@28221|Deltaproteobacteria,2MQX0@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4,Response_reg
REGS1_k127_5552297_2	909663.KI867150_gene2531	3.578e-53	189.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,42M1X@68525|delta/epsilon subdivisions,2WJA2@28221|Deltaproteobacteria,2MQ8Y@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Thiamine pyrophosphate enzyme, central	ilvB	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
REGS1_k127_5552297_0	909663.KI867150_gene2528	1.025e-140	452.0	COG0463@1|root,COG0463@2|Bacteria,1MWE5@1224|Proteobacteria,42NYX@68525|delta/epsilon subdivisions,2WJV8@28221|Deltaproteobacteria,2MQEX@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	PFAM Glycosyl transferase family 2	arnC	-	2.4.2.53	ko:K10012,ko:K20534	ko00520,ko01503,map00520,map01503	M00721,M00761	R07661	RC00005,RC02954	ko00000,ko00001,ko00002,ko01000,ko01005,ko02000	4.D.2.1.8,4.D.2.1.9	GT2	-	Glycos_transf_2
REGS1_k127_5552297_1	909663.KI867150_gene2527	7.889e-121	397.0	COG0223@1|root,COG0223@2|Bacteria,1MWH1@1224|Proteobacteria,42QSB@68525|delta/epsilon subdivisions,2WMWD@28221|Deltaproteobacteria,2MQSR@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Formyl transferase, C-terminal domain	arnG	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
REGS1_k127_5553694_1	243231.GSU1832	5.285e-47	175.0	COG1354@1|root,COG1354@2|Bacteria,1MVCN@1224|Proteobacteria,42RG5@68525|delta/epsilon subdivisions,2WNRE@28221|Deltaproteobacteria,43SVJ@69541|Desulfuromonadales	28221|Deltaproteobacteria	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	scpA	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
REGS1_k127_5553694_2	1111730.ATTM01000003_gene477	3.572e-07	56.0	COG0457@1|root,COG0457@2|Bacteria,4NJN9@976|Bacteroidetes,1HY86@117743|Flavobacteriia,2NVPE@237|Flavobacterium	976|Bacteroidetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_2,TPR_6,TPR_8
REGS1_k127_5553694_0	880073.Calab_2036	4.773e-61	214.0	COG0493@1|root,COG0493@2|Bacteria,2NNXN@2323|unclassified Bacteria	2|Bacteria	E	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	gltA	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	DHODB_Fe-S_bind,Fer4_20,NAD_binding_1,Pyr_redox_2
REGS1_k127_5559760_7	398767.Glov_1467	0.000729	44.0	COG3291@1|root,COG3291@2|Bacteria,1NS55@1224|Proteobacteria,43CPJ@68525|delta/epsilon subdivisions,2X7WV@28221|Deltaproteobacteria	1224|Proteobacteria	C	Chitobiase/beta-hexosaminidase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	CHB_HEX_C_1,Cytochrome_cB
REGS1_k127_5559760_5	1521187.JPIM01000076_gene1200	5.188e-07	54.0	COG5428@1|root,COG5428@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF2283)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2283
REGS1_k127_5559760_6	338963.Pcar_1791	6.5e-07	51.0	COG1943@1|root,COG1943@2|Bacteria,1MX0E@1224|Proteobacteria,42NN0@68525|delta/epsilon subdivisions,2WM14@28221|Deltaproteobacteria,43UIC@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	Transposase IS200 like	-	-	-	-	-	-	-	-	-	-	-	-	Bac_DnaA_C,Y1_Tnp
REGS1_k127_5559760_0	290317.Cpha266_0514	2.401e-171	546.0	COG0477@1|root,COG0477@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
REGS1_k127_5559760_1	289376.THEYE_A1244	1.1e-84	290.0	COG3431@1|root,COG3431@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Protoglobin,PsiE
REGS1_k127_5559760_3	243164.DET0624	6.786e-35	152.0	COG3437@1|root,COG3437@2|Bacteria,2G6QF@200795|Chloroflexi,34CZJ@301297|Dehalococcoidia	301297|Dehalococcoidia	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	HD,Response_reg
REGS1_k127_5559760_2	269799.Gmet_1910	3.653e-73	249.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,42N8M@68525|delta/epsilon subdivisions,2WJRT@28221|Deltaproteobacteria,43SXK@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdJ	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN
REGS1_k127_5603349_1	1123376.AUIU01000012_gene1406	1.419e-109	357.0	COG0064@1|root,COG0064@2|Bacteria,3J0FK@40117|Nitrospirae	40117|Nitrospirae	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
REGS1_k127_5603349_0	289376.THEYE_A1150	3.127e-227	712.0	COG0154@1|root,COG0154@2|Bacteria,3J0AA@40117|Nitrospirae	40117|Nitrospirae	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
REGS1_k127_5603349_2	1123376.AUIU01000013_gene1705	1.436e-31	128.0	COG3814@1|root,COG3814@2|Bacteria	2|Bacteria	S	Stringent starvation protein B	MA20_02250	-	-	ko:K09985	-	-	-	-	ko00000	-	-	-	SspB
REGS1_k127_5603349_3	517418.Ctha_1422	4.232e-28	123.0	COG4733@1|root,COG4733@2|Bacteria	2|Bacteria	S	cellulase activity	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_3_5,Big_5,fn3
REGS1_k127_5641237_2	1125863.JAFN01000001_gene381	7.736e-66	239.0	COG2199@1|root,COG3706@2|Bacteria,1REEI@1224|Proteobacteria,42RTM@68525|delta/epsilon subdivisions	1224|Proteobacteria	T	PFAM GGDEF domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GGDEF,HAMP
REGS1_k127_5641237_0	243231.GSU1939	2.188e-266	840.0	COG0642@1|root,COG2203@1|root,COG2206@1|root,COG2203@2|Bacteria,COG2205@2|Bacteria,COG2206@2|Bacteria,1NSAV@1224|Proteobacteria,42Z68@68525|delta/epsilon subdivisions,2WURV@28221|Deltaproteobacteria,43U68@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Domains GAF, HisKA, HATPase_c, GAF, HD-GYP-related	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HD_5,HisKA
REGS1_k127_5641237_1	880072.Desac_0172	2.703e-74	254.0	COG1680@1|root,COG3876@1|root,COG1680@2|Bacteria,COG3876@2|Bacteria,1MVPR@1224|Proteobacteria,42TQ5@68525|delta/epsilon subdivisions,2WQ0T@28221|Deltaproteobacteria,2MRV7@213462|Syntrophobacterales	28221|Deltaproteobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
REGS1_k127_5651173_4	404380.Gbem_1021	5.708e-74	251.0	COG1741@1|root,COG1741@2|Bacteria,1MWIP@1224|Proteobacteria,42N8V@68525|delta/epsilon subdivisions,2WJWB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
REGS1_k127_5651173_2	589865.DaAHT2_2402	1.731e-104	347.0	293RH@1|root,2ZR74@2|Bacteria,1RGTJ@1224|Proteobacteria,42RWW@68525|delta/epsilon subdivisions,2WNTI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554
REGS1_k127_5651173_6	589865.DaAHT2_2403	2.737e-24	105.0	2DG9R@1|root,2ZV2B@2|Bacteria,1P70I@1224|Proteobacteria,432AA@68525|delta/epsilon subdivisions,2WX9H@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_5651173_5	1280706.AUJE01000011_gene480	2.964e-71	251.0	COG0030@1|root,COG0030@2|Bacteria,1TP9W@1239|Firmicutes,4H210@909932|Negativicutes	909932|Negativicutes	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
REGS1_k127_5651173_1	289376.THEYE_A1148	2.258e-109	364.0	COG1995@1|root,COG1995@2|Bacteria,3J0GF@40117|Nitrospirae	40117|Nitrospirae	C	Pyridoxal phosphate biosynthetic protein PdxA	pdxA	-	1.1.1.262,1.1.1.408,1.1.1.409	ko:K00097,ko:K22024	ko00750,ko01100,map00750,map01100	M00124	R05681,R05837,R07406	RC00089,RC00675,RC01475	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxA
REGS1_k127_5651173_3	338966.Ppro_2985	2.331e-90	309.0	COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,42QUN@68525|delta/epsilon subdivisions,2WN6Q@28221|Deltaproteobacteria,43SIU@69541|Desulfuromonadales	28221|Deltaproteobacteria	OU	Peptidase family S49	sppA2	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
REGS1_k127_5651173_0	608538.HTH_1104	3.406e-124	407.0	COG1858@1|root,COG1858@2|Bacteria,2G4TF@200783|Aquificae	200783|Aquificae	C	Di-haem cytochrome c peroxidase	-	-	1.11.1.5	ko:K00428	-	-	-	-	ko00000,ko01000	-	-	-	CCP_MauG,Cytochrom_C
REGS1_k127_5655133_1	289376.THEYE_A0069	2.981e-112	391.0	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,3J0VB@40117|Nitrospirae	40117|Nitrospirae	S	Competence protein	-	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,Lactamase_B
REGS1_k127_5655133_0	671143.DAMO_1560	3.468e-161	521.0	COG1109@1|root,COG1109@2|Bacteria,2NNWU@2323|unclassified Bacteria	2|Bacteria	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	GO:0003674,GO:0003824,GO:0004614,GO:0004615,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006040,GO:0006047,GO:0006048,GO:0006139,GO:0006464,GO:0006468,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008966,GO:0009058,GO:0009225,GO:0009226,GO:0009987,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0018130,GO:0019438,GO:0019538,GO:0034641,GO:0034654,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046349,GO:0046483,GO:0046777,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901576	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_1886,iSBO_1134.SBO_3206	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
REGS1_k127_5655133_5	479436.Vpar_0293	3.317e-10	69.0	COG4856@1|root,COG4856@2|Bacteria,1TSIV@1239|Firmicutes,4H3WS@909932|Negativicutes	909932|Negativicutes	S	YbbR-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YbbR
REGS1_k127_5655133_2	289376.THEYE_A0044	2.668e-97	324.0	COG1624@1|root,COG1624@2|Bacteria,3J0XP@40117|Nitrospirae	40117|Nitrospirae	S	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria	dacA	-	2.7.7.85	ko:K18672	-	-	-	-	ko00000,ko01000	-	-	-	DisA_N
REGS1_k127_5655133_3	768670.Calni_1235	2.413e-56	202.0	COG1666@1|root,COG1666@2|Bacteria,2GFMW@200930|Deferribacteres	200930|Deferribacteres	S	Protein of unknown function (DUF520)	-	-	-	ko:K09767	-	-	-	-	ko00000	-	-	-	DUF520
REGS1_k127_5655133_4	768671.ThimaDRAFT_1465	3.514e-13	77.0	COG4083@1|root,COG4083@2|Bacteria,1RI8D@1224|Proteobacteria,1S812@1236|Gammaproteobacteria,1X10E@135613|Chromatiales	135613|Chromatiales	S	Transmembrane exosortase (Exosortase_EpsH)	-	-	-	-	-	-	-	-	-	-	-	-	Exosortase_EpsH
REGS1_k127_5671318_13	351160.RCIX2343	2.157e-11	64.0	COG2002@1|root,arCOG00822@2157|Archaea,2Y1VV@28890|Euryarchaeota,2NB89@224756|Methanomicrobia	224756|Methanomicrobia	K	SpoVT / AbrB like domain	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin
REGS1_k127_5671318_4	555088.DealDRAFT_3158	5.106e-88	303.0	COG1456@1|root,COG1456@2|Bacteria,1TPYJ@1239|Firmicutes	1239|Firmicutes	C	CO dehydrogenase acetyl-CoA synthase delta subunit	-	-	2.1.1.245	ko:K00197	ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200	M00357,M00377,M00422	R09096,R10219,R10243	RC00004,RC00113,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhD
REGS1_k127_5671318_9	913865.DOT_5807	3.342e-34	133.0	COG4231@1|root,COG4231@2|Bacteria,1VAJQ@1239|Firmicutes,24MVB@186801|Clostridia,262JW@186807|Peptococcaceae	186801|Clostridia	C	PFAM 4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_7
REGS1_k127_5671318_7	289376.THEYE_A0283	1.915e-45	168.0	COG2149@1|root,COG2149@2|Bacteria	2|Bacteria	S	membrane	-	-	-	ko:K00389	-	-	-	-	ko00000	-	-	-	DUF202
REGS1_k127_5671318_3	1232410.KI421417_gene2744	6.558e-108	355.0	COG2107@1|root,COG2107@2|Bacteria,1NYEA@1224|Proteobacteria,42MXB@68525|delta/epsilon subdivisions,2WIMS@28221|Deltaproteobacteria,43TEZ@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnD	-	-	ko:K11785	ko00130,ko01110,map00130,map01110	-	R08589	RC02330	ko00000,ko00001,ko01000	-	-	-	VitK2_biosynth
REGS1_k127_5671318_6	269799.Gmet_3381	8.118e-56	204.0	COG0775@1|root,COG0775@2|Bacteria,1NDXU@1224|Proteobacteria,42TU4@68525|delta/epsilon subdivisions,2WQX3@28221|Deltaproteobacteria,43U5Q@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnB	-	3.2.2.26	ko:K11783	ko00130,ko01110,map00130,map01110	-	R08587	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
REGS1_k127_5671318_1	289376.THEYE_A0631	2.697e-214	671.0	COG1158@1|root,COG1158@2|Bacteria,3J0BK@40117|Nitrospirae	40117|Nitrospirae	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
REGS1_k127_5671318_11	574087.Acear_0330	3.441e-21	100.0	COG2050@1|root,COG2050@2|Bacteria,1V824@1239|Firmicutes,24R76@186801|Clostridia,3WAU7@53433|Halanaerobiales	186801|Clostridia	Q	PFAM thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
REGS1_k127_5671318_8	404589.Anae109_0112	1.87e-38	155.0	COG0484@1|root,COG0484@2|Bacteria	2|Bacteria	O	heat shock protein binding	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_5671318_12	1449126.JQKL01000028_gene2588	8.013e-21	98.0	COG1765@1|root,COG1765@2|Bacteria,1V7SN@1239|Firmicutes,24NPX@186801|Clostridia	186801|Clostridia	O	redox protein regulator of disulfide bond formation	-	-	-	ko:K07397	-	-	-	-	ko00000	-	-	-	OsmC
REGS1_k127_5671318_0	1123376.AUIU01000013_gene1878	0.0	1259.0	COG0542@1|root,COG0542@2|Bacteria,3J0AV@40117|Nitrospirae	40117|Nitrospirae	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
REGS1_k127_5671318_10	289376.THEYE_A1929	2.577e-31	126.0	COG0789@1|root,COG0789@2|Bacteria	2|Bacteria	K	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding	hspR	GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	ko:K13640	-	-	-	-	ko00000,ko03000	-	-	-	MerR_1
REGS1_k127_5671318_2	1123376.AUIU01000013_gene1876	1.753e-111	371.0	COG0484@1|root,COG0484@2|Bacteria,3J0A7@40117|Nitrospirae	40117|Nitrospirae	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
REGS1_k127_5671318_5	289376.THEYE_A1948	7.026e-83	278.0	COG0205@1|root,COG0205@2|Bacteria,3J0Y1@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	-	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
REGS1_k127_5695782_2	401526.TcarDRAFT_1997	6.979e-31	124.0	COG0841@1|root,COG0841@2|Bacteria,1TQ03@1239|Firmicutes,4H20U@909932|Negativicutes	1239|Firmicutes	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
REGS1_k127_5695782_0	909663.KI867150_gene2030	4.31e-202	644.0	COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,42Q71@68525|delta/epsilon subdivisions,2WK8Q@28221|Deltaproteobacteria,2MQ91@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	Belongs to the 5'-nucleotidase family	-	-	3.1.3.5,3.6.1.45	ko:K11751,ko:K17224	ko00230,ko00240,ko00760,ko00920,ko01100,ko01110,ko01120,map00230,map00240,map00760,map00920,map01100,map01110,map01120	M00595	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346,R10151	RC00017,RC03151,RC03152	ko00000,ko00001,ko00002,ko01000	-	-	-	5_nucleotid_C,Metallophos
REGS1_k127_5695782_3	1211844.CBLM010000024_gene2191	5.813e-13	80.0	COG2804@1|root,COG2804@2|Bacteria,1TPGE@1239|Firmicutes,3VNXK@526524|Erysipelotrichia	526524|Erysipelotrichia	NU	Type II secretion system (T2SS), protein E, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	T2SSE,T2SSE_N
REGS1_k127_5695782_1	326427.Cagg_1565	1.254e-49	182.0	COG2353@1|root,COG2353@2|Bacteria,2G6G9@200795|Chloroflexi,376J9@32061|Chloroflexia	32061|Chloroflexia	S	Belongs to the UPF0312 family	-	-	-	-	-	-	-	-	-	-	-	-	YceI
REGS1_k127_5703823_6	1356854.N007_02110	3.172e-06	49.0	COG3829@1|root,COG3829@2|Bacteria,1TP0E@1239|Firmicutes,4HADT@91061|Bacilli,278Y5@186823|Alicyclobacillaceae	91061|Bacilli	K	Sigma-54 interaction domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,PAS,PrpR_N,Sigma54_activat
REGS1_k127_5703823_5	243231.GSU2743	5.433e-28	117.0	COG2010@1|root,COG2010@2|Bacteria,1P1Y0@1224|Proteobacteria,43213@68525|delta/epsilon subdivisions,2WWTT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	ko:K08906	ko00195,map00195	-	-	-	ko00000,ko00001,ko00194	-	-	-	Cytochrome_CBB3
REGS1_k127_5703823_0	1167006.UWK_01341	2.286e-185	592.0	COG3259@1|root,COG3259@2|Bacteria,1QUQ7@1224|Proteobacteria,42N63@68525|delta/epsilon subdivisions,2WJPA@28221|Deltaproteobacteria,2MHPB@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM nickel-dependent hydrogenase large subunit	mvhL	-	1.12.1.2,1.8.98.5	ko:K00436,ko:K14126	ko00680,map00680	-	R00019,R00700,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
REGS1_k127_5703823_3	1167006.UWK_01340	1.886e-107	355.0	COG1941@1|root,COG1941@2|Bacteria,1NS0E@1224|Proteobacteria,42U69@68525|delta/epsilon subdivisions,2WQJZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	NADH ubiquinone oxidoreductase 20 kDa subunit	hyhS	-	1.8.98.5	ko:K14128	ko00680,map00680	-	R00019,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	Oxidored_q6
REGS1_k127_5703823_2	1167006.UWK_01339	9.412e-126	409.0	COG0543@1|root,COG0543@2|Bacteria,1R6QZ@1224|Proteobacteria,42MVW@68525|delta/epsilon subdivisions,2WKKC@28221|Deltaproteobacteria,2MJAK@213118|Desulfobacterales	28221|Deltaproteobacteria	CH	Oxidoreductase FAD-binding domain	hyhG	-	-	-	-	-	-	-	-	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
REGS1_k127_5703823_1	1167006.UWK_01338	1.147e-141	457.0	COG1150@1|root,COG1150@2|Bacteria,1QWNB@1224|Proteobacteria,43BTA@68525|delta/epsilon subdivisions,2X741@28221|Deltaproteobacteria,2MI1V@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_22
REGS1_k127_5703823_4	933262.AXAM01000047_gene2337	5.895e-52	191.0	COG1413@1|root,COG1413@2|Bacteria,1RBEY@1224|Proteobacteria,42QE1@68525|delta/epsilon subdivisions,2WKQU@28221|Deltaproteobacteria,2MJEC@213118|Desulfobacterales	28221|Deltaproteobacteria	C	lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	zf-ribbon_3
REGS1_k127_5723833_0	289376.THEYE_A0859	1.459e-186	589.0	COG0466@1|root,COG0466@2|Bacteria,3J0DQ@40117|Nitrospirae	40117|Nitrospirae	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
REGS1_k127_5723833_3	289376.THEYE_A0858	1.456e-62	228.0	COG0611@1|root,COG0611@2|Bacteria,3J0TF@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
REGS1_k127_5723833_5	330214.NIDE3048	4.997e-22	100.0	COG3216@1|root,COG3216@2|Bacteria,3J1DC@40117|Nitrospirae	40117|Nitrospirae	S	Uncharacterized protein conserved in bacteria (DUF2062)	-	-	-	ko:K09928	-	-	-	-	ko00000	-	-	-	DUF2062
REGS1_k127_5723833_1	289376.THEYE_A0857	3.392e-130	428.0	COG0621@1|root,COG0621@2|Bacteria,3J0CD@40117|Nitrospirae	40117|Nitrospirae	J	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12	rimO	-	2.8.4.4	ko:K14441	-	-	R10652	RC00003,RC03217	ko00000,ko01000,ko03009	-	-	-	Radical_SAM,TRAM,UPF0004
REGS1_k127_5723833_2	289376.THEYE_A0856	1.422e-92	312.0	COG1994@1|root,COG1994@2|Bacteria,3J0KK@40117|Nitrospirae	40117|Nitrospirae	S	Peptidase family M50	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
REGS1_k127_5723833_4	443143.GM18_0017	2.464e-43	165.0	COG2067@1|root,COG2067@2|Bacteria,1MV7W@1224|Proteobacteria,42NZ4@68525|delta/epsilon subdivisions,2WQTT@28221|Deltaproteobacteria,43VJV@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	Outer membrane protein transport protein (OMPP1/FadL/TodX)	-	-	-	ko:K06076	-	-	-	-	ko00000,ko02000	1.B.9	-	-	Toluene_X
REGS1_k127_5724006_5	289376.THEYE_A1803	8.757e-22	101.0	28U9C@1|root,2ZGEW@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_5724006_2	269799.Gmet_0986	2.805e-70	246.0	COG1427@1|root,COG1427@2|Bacteria,1RCS0@1224|Proteobacteria,42SPW@68525|delta/epsilon subdivisions,2WP7F@28221|Deltaproteobacteria,43U6I@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnA	-	4.2.1.151	ko:K11782	ko00130,ko01110,map00130,map01110	-	R10666	RC03232	ko00000,ko00001,ko01000	-	-	-	VitK2_biosynth
REGS1_k127_5724006_0	289376.THEYE_A1750	3.153e-172	547.0	COG1690@1|root,COG1690@2|Bacteria,3J0X0@40117|Nitrospirae	40117|Nitrospirae	S	tRNA-splicing ligase RtcB	rtcB	-	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
REGS1_k127_5724006_3	374847.Kcr_1407	1.552e-35	137.0	COG1690@1|root,arCOG04246@2157|Archaea	2157|Archaea	L	Belongs to the RtcB family	rtcB	GO:0000166,GO:0000394,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003972,GO:0005488,GO:0006139,GO:0006388,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008380,GO:0008452,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016886,GO:0017076,GO:0019001,GO:0019002,GO:0030145,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901363	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Intein_splicing,LAGLIDADG_3,RtcB
REGS1_k127_5724006_4	289376.THEYE_A1749	1.605e-31	130.0	COG1371@1|root,COG1371@2|Bacteria	2|Bacteria	J	PFAM Archease protein family (DUF101 UPF0211)	-	-	-	-	-	-	-	-	-	-	-	-	Archease
REGS1_k127_5724006_7	1056495.Calag_0523	2.71e-05	53.0	arCOG00022@1|root,arCOG00022@2157|Archaea	2157|Archaea	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_5724006_6	330214.NIDE4083	2.456e-14	81.0	COG0671@1|root,COG0671@2|Bacteria,3J1CX@40117|Nitrospirae	40117|Nitrospirae	I	PAP2 superfamily	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
REGS1_k127_5724006_1	289376.THEYE_A1815	1.484e-143	471.0	COG1807@1|root,COG1807@2|Bacteria,3J12H@40117|Nitrospirae	40117|Nitrospirae	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_5726126_1	1304885.AUEY01000009_gene1980	9.946e-71	248.0	COG2885@1|root,COG2885@2|Bacteria,1MWHF@1224|Proteobacteria	1224|Proteobacteria	M	Belongs to the ompA family	-	-	-	ko:K03286	-	-	-	-	ko00000,ko02000	1.B.6	-	-	BON,OMP_b-brl,OmpA
REGS1_k127_5726126_3	1278073.MYSTI_01659	3.71e-31	125.0	COG5531@1|root,COG5531@2|Bacteria,1N3MD@1224|Proteobacteria,430NN@68525|delta/epsilon subdivisions,2WVYS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	B	SWI complex, BAF60b domains	-	-	-	-	-	-	-	-	-	-	-	-	SWIB
REGS1_k127_5726126_4	261292.Nit79A3_0929	7.033e-11	68.0	COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,2VI13@28216|Betaproteobacteria,372T8@32003|Nitrosomonadales	28216|Betaproteobacteria	NT	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	cheB	-	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,Response_reg
REGS1_k127_5726126_0	547144.HydHO_0782	4.199e-161	539.0	COG0204@1|root,COG1022@1|root,COG0204@2|Bacteria,COG1022@2|Bacteria,2G3NC@200783|Aquificae	200783|Aquificae	I	PFAM AMP-dependent synthetase and ligase	fadD	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C,Acyltransferase,PP-binding
REGS1_k127_5726126_2	335543.Sfum_1244	4.228e-59	216.0	2CB8R@1|root,2Z90U@2|Bacteria,1R4DV@1224|Proteobacteria,42R2G@68525|delta/epsilon subdivisions,2WMQS@28221|Deltaproteobacteria,2MRR0@213462|Syntrophobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_5766752_1	523791.Kkor_0965	1.839e-69	240.0	COG0302@1|root,COG0302@2|Bacteria,1MY3N@1224|Proteobacteria,1RMQM@1236|Gammaproteobacteria,1XIJW@135619|Oceanospirillales	135619|Oceanospirillales	H	catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water	folE	-	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydroI
REGS1_k127_5766752_3	330779.Saci_1101	4.978e-41	157.0	COG0801@1|root,arCOG07203@2157|Archaea	2157|Archaea	H	Dihydroneopterin aldolase	-	-	-	-	-	-	-	-	-	-	-	-	FolB,HPPK
REGS1_k127_5766752_4	1499967.BAYZ01000145_gene6206	7.645e-36	139.0	COG1539@1|root,COG1539@2|Bacteria,2NQ1A@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin	folX	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0008719,GO:0009987,GO:0016853,GO:0019752,GO:0034641,GO:0042558,GO:0043436,GO:0043603,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0071704,GO:1901360,GO:1901564	1.13.11.81,4.1.2.25,5.1.99.7,5.1.99.8	ko:K01633,ko:K07589	ko00790,ko01100,map00790,map01100	M00126,M00840	R03504,R11037,R11073,R11082	RC00721,RC00943,RC01479,RC03333,RC03334	ko00000,ko00001,ko00002,ko01000	-	-	-	FolB
REGS1_k127_5766752_2	1499967.BAYZ01000145_gene6207	6.899e-64	228.0	COG1028@1|root,COG1028@2|Bacteria,2NQVU@2323|unclassified Bacteria	2|Bacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.5.1.33	ko:K03793	-	-	-	-	ko00000,ko01000	-	-	-	adh_short_C2
REGS1_k127_5766752_5	293826.Amet_4266	2.196e-19	91.0	COG2154@1|root,COG2154@2|Bacteria,1VERE@1239|Firmicutes,24NE1@186801|Clostridia,36SAJ@31979|Clostridiaceae	186801|Clostridia	H	Pterin 4 alpha carbinolamine dehydratase	-	-	4.2.1.96	ko:K01724	ko00790,map00790	-	R04734	RC01208	ko00000,ko00001,ko01000,ko04147	-	-	-	Pterin_4a
REGS1_k127_5766752_0	697282.Mettu_0616	8.988e-108	362.0	COG0446@1|root,COG0446@2|Bacteria,1NR3M@1224|Proteobacteria,1RN6P@1236|Gammaproteobacteria,1XEW5@135618|Methylococcales	135618|Methylococcales	C	Apoptosis-inducing factor, mitochondrion-associated, C-term	-	-	-	-	-	-	-	-	-	-	-	-	AIF_C,Pyr_redox_2
REGS1_k127_5766999_1	589865.DaAHT2_1392	2.609e-09	59.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,42QN5@68525|delta/epsilon subdivisions,2WMD7@28221|Deltaproteobacteria,2MJC9@213118|Desulfobacterales	28221|Deltaproteobacteria	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
REGS1_k127_5766999_0	96561.Dole_0153	1.69e-67	250.0	28M0D@1|root,2ZAFE@2|Bacteria,1R6YH@1224|Proteobacteria,42NPF@68525|delta/epsilon subdivisions,2WM7K@28221|Deltaproteobacteria,2MIG7@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Putative ATP-binding cassette	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran_2
REGS1_k127_5766999_2	589865.DaAHT2_2441	9.353e-06	48.0	COG3746@1|root,COG3746@2|Bacteria,1QXPF@1224|Proteobacteria,42TW0@68525|delta/epsilon subdivisions,2WQ4G@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	PFAM Phosphate-selective porin O and P	-	-	-	-	-	-	-	-	-	-	-	-	Porin_O_P
REGS1_k127_5787534_0	335543.Sfum_0739	5.031e-301	934.0	COG0308@1|root,COG0308@2|Bacteria,1MUCI@1224|Proteobacteria,42KZI@68525|delta/epsilon subdivisions,2WJ2C@28221|Deltaproteobacteria,2MQX8@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	Domain of unknown function (DUF3458_C) ARM repeats	pepN	-	3.4.11.2	ko:K01256,ko:K08776	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3458,DUF3458_C,ERAP1_C,HEAT_2,Peptidase_M1
REGS1_k127_5787534_3	555079.Toce_1201	4.508e-125	413.0	COG0334@1|root,COG0334@2|Bacteria,1TP45@1239|Firmicutes,24960@186801|Clostridia,42FA1@68295|Thermoanaerobacterales	186801|Clostridia	C	Belongs to the Glu Leu Phe Val dehydrogenases family	-	-	1.4.1.2,1.4.1.3,1.4.1.4	ko:K00260,ko:K00261,ko:K00262	ko00220,ko00250,ko00430,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00430,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
REGS1_k127_5787534_8	1123376.AUIU01000016_gene219	5.789e-21	99.0	COG2142@1|root,COG2142@2|Bacteria	2|Bacteria	C	succinate dehydrogenase activity	sdhD	-	-	ko:K00242,ko:K00246	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00149,M00150,M00173	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
REGS1_k127_5787534_7	289376.THEYE_A0772	3.391e-23	103.0	COG2009@1|root,COG2009@2|Bacteria	2|Bacteria	C	succinate dehydrogenase	-	-	-	ko:K00241,ko:K00247	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00149,M00150,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
REGS1_k127_5787534_6	1121440.AUMA01000009_gene680	6.957e-78	266.0	COG0517@1|root,COG0517@2|Bacteria,1RA25@1224|Proteobacteria,42R80@68525|delta/epsilon subdivisions,2WMW6@28221|Deltaproteobacteria,2ME90@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	ko:K04767	-	-	-	-	ko00000	-	-	-	CBS
REGS1_k127_5787534_5	1125863.JAFN01000001_gene1061	3.213e-92	309.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,42MSC@68525|delta/epsilon subdivisions,2WJAH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	ABC transporter related	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
REGS1_k127_5787534_4	1121440.AUMA01000009_gene682	1.778e-106	350.0	COG0411@1|root,COG0411@2|Bacteria,1MUFT@1224|Proteobacteria,42QV6@68525|delta/epsilon subdivisions,2WMN1@28221|Deltaproteobacteria,2M9HK@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	pfam abc	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
REGS1_k127_5787534_2	1121440.AUMA01000009_gene683	8.213e-131	430.0	COG4177@1|root,COG4177@2|Bacteria,1MU52@1224|Proteobacteria,42RI3@68525|delta/epsilon subdivisions,2WNVC@28221|Deltaproteobacteria,2MA30@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
REGS1_k127_5787534_1	1121440.AUMA01000009_gene684	7.723e-150	478.0	COG0559@1|root,COG0559@2|Bacteria,1N5XH@1224|Proteobacteria,42PN7@68525|delta/epsilon subdivisions,2WIRP@28221|Deltaproteobacteria,2M8YK@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
REGS1_k127_5788939_1	63737.Npun_F3675	1.65e-68	251.0	COG4251@1|root,COG5278@1|root,COG4251@2|Bacteria,COG5278@2|Bacteria,1G2QC@1117|Cyanobacteria,1HR6C@1161|Nostocales	1117|Cyanobacteria	T	Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,PAS_3,PAS_4
REGS1_k127_5788939_3	316067.Geob_3568	1.642e-40	152.0	COG4251@1|root,COG4251@2|Bacteria,1N44A@1224|Proteobacteria,431XF@68525|delta/epsilon subdivisions,2WWPK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	KaiB	-	-	-	ko:K08481	-	-	-	-	ko00000	-	-	-	KaiB
REGS1_k127_5788939_2	28072.Nos7524_2637	9.175e-43	159.0	COG4251@1|root,COG4251@2|Bacteria,1G7XH@1117|Cyanobacteria,1HSW9@1161|Nostocales	1117|Cyanobacteria	T	KaiB	-	-	-	ko:K08481	-	-	-	-	ko00000	-	-	-	KaiB
REGS1_k127_5788939_0	316067.Geob_3570	2.678e-133	434.0	COG0467@1|root,COG0467@2|Bacteria,1NEWW@1224|Proteobacteria,42P4F@68525|delta/epsilon subdivisions,2WJVT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Pfam:KaiC	-	-	-	ko:K08482	-	-	-	-	ko00000	-	-	-	ATPase
REGS1_k127_5790659_6	1057002.KB905370_gene3535	8.302e-05	54.0	COG3391@1|root,COG3391@2|Bacteria,1P862@1224|Proteobacteria,2TR6Z@28211|Alphaproteobacteria,4BDNX@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	TIGRFAM 40-residue YVTN family beta-propeller repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_D1,Lactonase
REGS1_k127_5790659_0	456442.Mboo_2006	7.957e-68	246.0	COG0577@1|root,arCOG02312@2157|Archaea	2157|Archaea	V	ABC-type antimicrobial peptide transport system, permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
REGS1_k127_5790659_5	264732.Moth_1598	1.263e-14	82.0	COG0457@1|root,COG0457@2|Bacteria,1VBE6@1239|Firmicutes,25NPZ@186801|Clostridia,42HFH@68295|Thermoanaerobacterales	186801|Clostridia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_2,TPR_8
REGS1_k127_5790659_2	383372.Rcas_0694	3.583e-57	206.0	COG1136@1|root,COG1136@2|Bacteria,2G69N@200795|Chloroflexi,376XE@32061|Chloroflexia	32061|Chloroflexia	V	Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides	macB	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
REGS1_k127_5790659_1	289376.THEYE_A0927	3.135e-60	216.0	COG4123@1|root,COG4123@2|Bacteria	2|Bacteria	AJ	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)	smtA	-	2.1.1.172,2.1.1.223	ko:K00564,ko:K15460	-	-	R07234	RC00003	ko00000,ko01000,ko03009,ko03016	-	-	-	MTS,Methyltransf_31
REGS1_k127_5790659_3	289376.THEYE_A2088	1.461e-54	199.0	COG0546@1|root,COG0546@2|Bacteria,3J0QE@40117|Nitrospirae	40117|Nitrospirae	S	HAD-hyrolase-like	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
REGS1_k127_5790659_4	909663.KI867150_gene1773	5.494e-49	176.0	COG1403@1|root,COG1403@2|Bacteria,1RGZQ@1224|Proteobacteria,42UXJ@68525|delta/epsilon subdivisions,2WQ0I@28221|Deltaproteobacteria,2MS3A@213462|Syntrophobacterales	28221|Deltaproteobacteria	V	HNH nucleases	-	-	-	-	-	-	-	-	-	-	-	-	HNH
REGS1_k127_5832262_3	1123376.AUIU01000013_gene1881	5.066e-53	188.0	COG0054@1|root,COG0054@2|Bacteria,3J0QT@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
REGS1_k127_5832262_4	289376.THEYE_A1848	2.21e-32	131.0	COG0781@1|root,COG0781@2|Bacteria,3J0RV@40117|Nitrospirae	40117|Nitrospirae	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
REGS1_k127_5832262_2	946483.Cenrod_2114	3.593e-94	315.0	COG2003@1|root,COG2003@2|Bacteria,1MXZ5@1224|Proteobacteria,2VKTW@28216|Betaproteobacteria,4ABDV@80864|Comamonadaceae	28216|Betaproteobacteria	E	Belongs to the UPF0758 family	-	-	-	ko:K03630	-	-	-	-	ko00000	-	-	-	RadC
REGS1_k127_5832262_1	289376.THEYE_A0555	5.966e-196	619.0	COG0015@1|root,COG0015@2|Bacteria,3J0EM@40117|Nitrospirae	40117|Nitrospirae	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	purB	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
REGS1_k127_5832262_0	289376.THEYE_A0629	0.0	1680.0	COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,3J0TJ@40117|Nitrospirae	40117|Nitrospirae	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C,GATase_5
REGS1_k127_5878334_1	452637.Oter_3648	5.938e-14	78.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	ko:K12263	-	-	-	-	ko00000	-	-	-	Cytochrome_CBB3,SirB
REGS1_k127_5878334_0	289376.THEYE_A1214	2.818e-107	355.0	COG0382@1|root,COG0382@2|Bacteria,3J0TY@40117|Nitrospirae	40117|Nitrospirae	H	UbiA prenyltransferase family	-	-	2.5.1.39	ko:K03179	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R05000,R05615	RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
REGS1_k127_5888184_0	269799.Gmet_2983	8.073e-128	425.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,42NAV@68525|delta/epsilon subdivisions,2WJ3W@28221|Deltaproteobacteria,43TIJ@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
REGS1_k127_5890005_5	289376.THEYE_A1058	1.112e-87	313.0	COG3005@1|root,COG3005@2|Bacteria	2|Bacteria	C	denitrification pathway	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_c3_2,Cytochrome_C554,Ni_hydr_CYTB,Paired_CXXCH_1
REGS1_k127_5890005_6	289376.THEYE_A1057	6.734e-76	259.0	COG4117@1|root,COG4117@2|Bacteria	2|Bacteria	C	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)	ydhU	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03620,ko:K08354	ko00920,ko01120,ko02020,map00920,map01120,map02020	-	R10149	RC02823	ko00000,ko00001,ko02000	5.A.3.5	-	-	Cytochrome_C7,Ni_hydr_CYTB
REGS1_k127_5890005_10	690850.Desaf_0190	5.009e-40	156.0	COG2854@1|root,COG2854@2|Bacteria,1N275@1224|Proteobacteria	1224|Proteobacteria	Q	PFAM toluene tolerance	-	-	-	ko:K07323	ko02010,map02010	M00210	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27.3	-	-	MlaC
REGS1_k127_5890005_2	105559.Nwat_1369	1.575e-175	584.0	COG1033@1|root,COG1033@2|Bacteria,1QW3H@1224|Proteobacteria,1RZA3@1236|Gammaproteobacteria,1X2NT@135613|Chromatiales	135613|Chromatiales	S	TIGRFAM hopanoid biosynthesis associated RND transporter like protein HpnN	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
REGS1_k127_5890005_1	1380394.JADL01000005_gene5573	4.571e-176	565.0	COG1032@1|root,COG1032@2|Bacteria,1MWR0@1224|Proteobacteria,2TRFJ@28211|Alphaproteobacteria,2JRB5@204441|Rhodospirillales	204441|Rhodospirillales	C	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
REGS1_k127_5890005_8	46234.ANA_C13135	2.373e-47	181.0	COG3394@1|root,COG3394@2|Bacteria,1G2GK@1117|Cyanobacteria,1HJHS@1161|Nostocales	1117|Cyanobacteria	G	YdjC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	GtrA,YdjC
REGS1_k127_5890005_12	269799.Gmet_2414	1.732e-21	100.0	COG2510@1|root,COG2510@2|Bacteria,1NDZV@1224|Proteobacteria,42V6K@68525|delta/epsilon subdivisions,2WRTX@28221|Deltaproteobacteria,43UXY@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
REGS1_k127_5890005_0	243231.GSU0688	2.481e-233	739.0	COG1657@1|root,COG1657@2|Bacteria,1MUIP@1224|Proteobacteria,42Q4W@68525|delta/epsilon subdivisions,2WJ9H@28221|Deltaproteobacteria,43UJ3@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	Squalene-hopene cyclase C-terminal domain	shc-1	-	4.2.1.129,5.4.99.17,5.4.99.7	ko:K01852,ko:K06045	ko00100,ko00909,ko01100,ko01110,ko01130,map00100,map00909,map01100,map01110,map01130	M00101	R03199,R07322,R07323	RC00874,RC01850,RC01851	ko00000,ko00001,ko00002,ko01000	-	-	-	SQHop_cyclase_C,SQHop_cyclase_N
REGS1_k127_5890005_3	269799.Gmet_2821	1.384e-122	402.0	COG0451@1|root,COG0451@2|Bacteria,1MW32@1224|Proteobacteria,42NJT@68525|delta/epsilon subdivisions,2WM7E@28221|Deltaproteobacteria,43UJ6@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	NmrA-like family	hpnA	-	1.1.1.219	ko:K00091	-	-	-	-	ko00000,ko01000	-	-	-	Epimerase
REGS1_k127_5890005_9	1157490.EL26_01200	1.386e-42	166.0	COG1852@1|root,COG1852@2|Bacteria,1V1B5@1239|Firmicutes,4HUDI@91061|Bacilli,279H3@186823|Alicyclobacillaceae	91061|Bacilli	S	Protein of unknown function DUF116	-	-	-	-	-	-	-	-	-	-	-	-	DUF116
REGS1_k127_5890005_4	335543.Sfum_0865	9.651e-119	390.0	COG0535@1|root,COG0535@2|Bacteria,1MXM1@1224|Proteobacteria,42PCW@68525|delta/epsilon subdivisions,2WMDU@28221|Deltaproteobacteria,2MRE8@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Radical SAM domain protein	hpnH	-	-	-	-	-	-	-	-	-	-	-	DUF3463,Fer4_12,Fer4_14,Radical_SAM
REGS1_k127_5890005_7	335543.Sfum_0866	2.106e-75	261.0	COG2324@1|root,COG2324@2|Bacteria,1RCF6@1224|Proteobacteria,42QNN@68525|delta/epsilon subdivisions,2WN3U@28221|Deltaproteobacteria,2MRMC@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Carotenoid biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Caroten_synth
REGS1_k127_5890005_13	398767.Glov_0361	1.648e-18	95.0	COG0775@1|root,COG0775@2|Bacteria,1Q1C0@1224|Proteobacteria,43EX0@68525|delta/epsilon subdivisions,2WRFZ@28221|Deltaproteobacteria,43V4A@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	PFAM purine or other phosphorylase family 1	-	-	3.2.2.9	ko:K01243	ko00270,ko01100,ko01230,map00270,map01100,map01230	M00034,M00609	R00194,R01401	RC00063,RC00318	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
REGS1_k127_5890005_11	243231.GSU0697	3.556e-32	133.0	COG1215@1|root,COG1215@2|Bacteria,1PC79@1224|Proteobacteria,42QYP@68525|delta/epsilon subdivisions,2X6HG@28221|Deltaproteobacteria,43UDX@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Glycosyl transferase family group 2	hpnI	-	2.4.1.80	ko:K00720	ko00600,ko01100,map00600,map01100	M00066	R01497	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko02000	4.D.1.4	GT21	-	Glyco_transf_21
REGS1_k127_5906435_0	1123376.AUIU01000012_gene1485	6.65e-120	392.0	COG0195@1|root,COG0195@2|Bacteria,3J0DF@40117|Nitrospirae	40117|Nitrospirae	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_5,NusA_N,S1
REGS1_k127_5906435_1	289376.THEYE_A0698	3.592e-34	136.0	COG0779@1|root,COG0779@2|Bacteria,3J0UD@40117|Nitrospirae	40117|Nitrospirae	J	Required for maturation of 30S ribosomal subunits	rimP	GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576	-	ko:K09748	-	-	-	-	ko00000,ko03009	-	-	-	DUF150,DUF150_C
REGS1_k127_5906435_2	521000.PROVRETT_07268	7.278e-08	55.0	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,1RPIW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	N-acyl-D-aspartate D-glutamate deacylase	dan	-	3.5.1.81,3.5.1.82	ko:K01461,ko:K06015	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Amidohydro_3
REGS1_k127_5941123_0	247490.KSU1_D0230	4.088e-62	235.0	COG2199@1|root,COG2203@1|root,COG3452@1|root,COG2199@2|Bacteria,COG2203@2|Bacteria,COG3452@2|Bacteria	2|Bacteria	T	CHASE	ytrP	-	2.7.7.65	ko:K02488,ko:K21009	ko02020,ko02025,ko04112,map02020,map02025,map04112	M00511	R08057	-	ko00000,ko00001,ko00002,ko01000,ko02022	-	-	-	CHASE,GAF,GAF_2,GGDEF,HATPase_c,HisKA,PAS_3,PAS_8,Response_reg
REGS1_k127_5941123_2	671143.DAMO_2368	3.013e-07	60.0	COG3678@1|root,COG3678@2|Bacteria,2NRWA@2323|unclassified Bacteria	2|Bacteria	NPTU	Evidence 5 No homology to any previously reported sequences	-	-	-	-	-	-	-	-	-	-	-	-	Metal_resist
REGS1_k127_5941123_1	56780.SYN_03004	3.852e-25	111.0	COG3064@1|root,COG3064@2|Bacteria,1R7D3@1224|Proteobacteria,42Y44@68525|delta/epsilon subdivisions,2X6IP@28221|Deltaproteobacteria,2MRQW@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_5965426_10	742723.HMPREF9477_01883	3.687e-21	97.0	COG2109@1|root,COG2109@2|Bacteria,1V70U@1239|Firmicutes,24JNB@186801|Clostridia,27TTR@186928|unclassified Lachnospiraceae	186801|Clostridia	H	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP	btuR	-	2.5.1.17	ko:K19221	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	CobA_CobO_BtuR
REGS1_k127_5965426_6	289376.THEYE_A1393	8.655e-50	183.0	COG0558@1|root,COG0558@2|Bacteria	2|Bacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA1	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf,DUF4833
REGS1_k127_5965426_1	289376.THEYE_A1394	1.465e-162	518.0	COG1260@1|root,COG1260@2|Bacteria	2|Bacteria	I	inositol-3-phosphate synthase activity	ino1	GO:0003674,GO:0003824,GO:0004512,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009405,GO:0009987,GO:0010125,GO:0010126,GO:0016137,GO:0016138,GO:0016853,GO:0016872,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044272,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth
REGS1_k127_5965426_2	909663.KI867150_gene1374	2.474e-118	392.0	COG0039@1|root,COG0039@2|Bacteria,1MV57@1224|Proteobacteria,42KZJ@68525|delta/epsilon subdivisions,2WJ4U@28221|Deltaproteobacteria,2MQPY@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	-	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
REGS1_k127_5965426_3	335543.Sfum_0500	2.852e-109	358.0	COG0105@1|root,COG0105@2|Bacteria,1R9ZA@1224|Proteobacteria,42RIR@68525|delta/epsilon subdivisions,2WP3R@28221|Deltaproteobacteria,2MSCP@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:0072521,GO:0072527,GO:1901360,GO:1901564	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
REGS1_k127_5965426_0	330214.NIDE2457	0.0	1099.0	COG0542@1|root,COG0542@2|Bacteria,3J0B4@40117|Nitrospirae	40117|Nitrospirae	O	C-terminal, D2-small domain, of ClpB protein	-	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
REGS1_k127_5965426_9	289376.THEYE_A0252	1.281e-33	135.0	COG0526@1|root,COG0526@2|Bacteria,3J0SG@40117|Nitrospirae	40117|Nitrospirae	CO	Thioredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
REGS1_k127_5965426_8	289376.THEYE_A0253	2.872e-37	146.0	2CA4A@1|root,32RQK@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4416)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4416
REGS1_k127_5965426_4	289376.THEYE_A0805	7.685e-90	301.0	COG0299@1|root,COG0299@2|Bacteria,3J0MC@40117|Nitrospirae	40117|Nitrospirae	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	purN	-	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	Formyl_trans_N
REGS1_k127_5965426_5	1123376.AUIU01000013_gene1863	1.02e-69	248.0	COG0760@1|root,COG0760@2|Bacteria,3J0SR@40117|Nitrospirae	40117|Nitrospirae	O	SurA N-terminal domain	-	-	5.2.1.8	ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase_3,SurA_N
REGS1_k127_5965426_7	555779.Dthio_PD3232	3.542e-41	154.0	COG1905@1|root,COG1905@2|Bacteria,1RHBU@1224|Proteobacteria,42U8S@68525|delta/epsilon subdivisions,2WQ8V@28221|Deltaproteobacteria,2MAD2@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Thioredoxin-like [2Fe-2S] ferredoxin	nuoE-1	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
REGS1_k127_5984609_6	247490.KSU1_C1013	3.968e-66	231.0	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	yvkB	GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0043565,GO:0044212,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1903506,GO:1990837,GO:2000112,GO:2001141	-	-	-	-	-	-	-	-	-	-	Phage_integrase,TetR_C_11,TetR_N
REGS1_k127_5984609_2	56780.SYN_01993	1.995e-137	447.0	COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,42NVA@68525|delta/epsilon subdivisions,2WMQK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	HlyD_D23
REGS1_k127_5984609_5	1304874.JAFY01000002_gene147	8.625e-95	316.0	COG1136@1|root,COG1136@2|Bacteria,3TAPT@508458|Synergistetes	508458|Synergistetes	P	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
REGS1_k127_5984609_1	56780.SYN_01995	3.674e-194	612.0	COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,42MAR@68525|delta/epsilon subdivisions,2WJEU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	ABC-type antimicrobial peptide transport system, permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
REGS1_k127_5984609_3	909663.KI867150_gene151	9.795e-123	409.0	COG1538@1|root,COG1538@2|Bacteria,1Q1F4@1224|Proteobacteria,42NUU@68525|delta/epsilon subdivisions,2WK3P@28221|Deltaproteobacteria,2MRMW@213462|Syntrophobacterales	28221|Deltaproteobacteria	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
REGS1_k127_5984609_4	909663.KI867150_gene63	2.036e-117	388.0	COG1566@1|root,COG1566@2|Bacteria,1MU7I@1224|Proteobacteria,42NIC@68525|delta/epsilon subdivisions,2WKV5@28221|Deltaproteobacteria,2MQDK@213462|Syntrophobacterales	28221|Deltaproteobacteria	V	HlyD membrane-fusion protein of T1SS	-	-	-	ko:K03543	-	M00701	-	-	ko00000,ko00002,ko02000	8.A.1.1	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
REGS1_k127_5984609_0	909663.KI867150_gene149	1.34e-233	732.0	COG0477@1|root,COG0477@2|Bacteria,1RGPN@1224|Proteobacteria,43BMI@68525|delta/epsilon subdivisions,2X6ZQ@28221|Deltaproteobacteria,2MQAD@213462|Syntrophobacterales	28221|Deltaproteobacteria	EGP	Sugar (and other) transporter	-	-	-	ko:K03446	-	M00701	-	-	ko00000,ko00002,ko02000	2.A.1.3	-	-	MFS_1
REGS1_k127_5984609_7	926550.CLDAP_21560	5.186e-13	82.0	COG5305@1|root,COG5305@2|Bacteria,2G7AA@200795|Chloroflexi	200795|Chloroflexi	S	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
REGS1_k127_5985456_7	637389.Acaty_c2485	2.841e-08	64.0	COG3307@1|root,COG3307@2|Bacteria,1PEP9@1224|Proteobacteria,1T8HT@1236|Gammaproteobacteria,2NCXB@225057|Acidithiobacillales	225057|Acidithiobacillales	M	O-Antigen ligase	-	-	-	ko:K02847	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01005,ko02000	9.B.67.4,9.B.67.5	-	-	Wzy_C
REGS1_k127_5985456_1	667014.Thein_0689	9.1e-87	294.0	COG1215@1|root,COG1215@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	hyaD	-	2.4.1.175,2.4.1.226	ko:K13500	ko00532,ko01100,map00532,map01100	-	R04603,R05931,R05932,R05933,R05934,R07336	RC00005,RC00049	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glyco_transf_7C,Glycos_transf_2
REGS1_k127_5985456_0	443144.GM21_3415	8.313e-153	502.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,42M01@68525|delta/epsilon subdivisions,2WJ7M@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation	msbA	-	-	ko:K06147,ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
REGS1_k127_5985456_6	1206101.AZXC01000031_gene5168	1.124e-09	66.0	COG1437@1|root,COG1437@2|Bacteria,2GNX6@201174|Actinobacteria	201174|Actinobacteria	F	CYTH domain	-	-	4.6.1.1	ko:K05873	ko00230,map00230	-	R00089,R00434	RC00295	ko00000,ko00001,ko01000	-	-	-	CYTH
REGS1_k127_5985456_4	289376.THEYE_A1823	7.229e-32	128.0	COG0776@1|root,COG0776@2|Bacteria,3J0V6@40117|Nitrospirae	40117|Nitrospirae	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions	-	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
REGS1_k127_5985456_3	56780.SYN_02018	2.814e-35	137.0	COG0011@1|root,COG0011@2|Bacteria,1N0UT@1224|Proteobacteria,43B8R@68525|delta/epsilon subdivisions	1224|Proteobacteria	S	Thiamine-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Thiamine_BP
REGS1_k127_5985456_5	1125863.JAFN01000001_gene229	3.357e-18	87.0	2EH48@1|root,33AW7@2|Bacteria,1NIYU@1224|Proteobacteria,42XKK@68525|delta/epsilon subdivisions,2WSKU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_5985456_2	289376.THEYE_A1333	1.398e-46	171.0	COG0156@1|root,COG0156@2|Bacteria,3J0XU@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide	-	-	2.3.1.47	ko:K00652	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03210,R10124	RC00004,RC00039,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
REGS1_k127_5997417_1	177437.HRM2_25550	1.848e-87	303.0	COG5338@1|root,COG5338@2|Bacteria,1QTI0@1224|Proteobacteria,42PG4@68525|delta/epsilon subdivisions,2WKB2@28221|Deltaproteobacteria,2MJF0@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Putative beta-barrel porin 2	-	-	-	ko:K20920	ko05111,map05111	-	-	-	ko00000,ko00001,ko02000	1.B.66.3.1,1.B.66.3.2	-	-	BBP2_2
REGS1_k127_5997417_2	1121403.AUCV01000014_gene4607	2.087e-84	290.0	COG1596@1|root,COG1596@2|Bacteria,1N7GP@1224|Proteobacteria,42MNP@68525|delta/epsilon subdivisions,2WMJZ@28221|Deltaproteobacteria,2MJAM@213118|Desulfobacterales	28221|Deltaproteobacteria	M	export protein	wza2	-	-	ko:K01991	ko02026,map02026	-	-	-	ko00000,ko00001,ko02000	1.B.18	-	-	Poly_export,SLBB
REGS1_k127_5997417_0	177437.HRM2_25570	2.042e-102	346.0	COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,1MVI9@1224|Proteobacteria,42NB4@68525|delta/epsilon subdivisions,2WK9E@28221|Deltaproteobacteria,2MHUB@213118|Desulfobacterales	28221|Deltaproteobacteria	D	G-rich domain on putative tyrosine kinase	wzc2	-	-	ko:K16554	ko05111,map05111	-	-	-	ko00000,ko00001,ko02000	8.A.3.1	-	-	AAA_31,CbiA,GNVR,ParA,Wzz
REGS1_k127_6003397_10	269799.Gmet_0139	1.401e-23	111.0	COG5295@1|root,COG5295@2|Bacteria	2|Bacteria	UW	Hep Hag repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	Pectinesterase,YadA_stalk
REGS1_k127_6003397_7	243231.GSU3317	7.442e-28	125.0	COG5295@1|root,COG5295@2|Bacteria	2|Bacteria	UW	Hep Hag repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	Pectinesterase,YadA_stalk
REGS1_k127_6003397_4	555779.Dthio_PD2102	1.214e-54	200.0	2FCCG@1|root,344G3@2|Bacteria,1P0M6@1224|Proteobacteria,431HA@68525|delta/epsilon subdivisions,2WX59@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_6003397_15	574087.Acear_0855	6.933e-06	56.0	COG0745@1|root,COG0745@2|Bacteria,1TPWS@1239|Firmicutes,25AZ2@186801|Clostridia,3WAJ5@53433|Halanaerobiales	186801|Clostridia	K	PFAM response regulator receiver	phoP	-	-	ko:K02483,ko:K07658,ko:K07668	ko02020,map02020	M00434,M00459	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
REGS1_k127_6003397_6	1151117.AJLF01000001_gene746	7.201e-42	162.0	COG0009@1|root,arCOG01952@2157|Archaea,2XVGC@28890|Euryarchaeota,243AA@183968|Thermococci	183968|Thermococci	J	required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine	-	GO:0002949,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	SUA5,Sua5_yciO_yrdC
REGS1_k127_6003397_11	880072.Desac_1064	1.276e-21	97.0	COG0724@1|root,COG0724@2|Bacteria,1N6VR@1224|Proteobacteria,42V9Q@68525|delta/epsilon subdivisions,2WRRT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM RNP-1 like RNA-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
REGS1_k127_6003397_2	1487923.DP73_13035	1.937e-65	236.0	COG1578@1|root,COG1578@2|Bacteria,1UURD@1239|Firmicutes,2492C@186801|Clostridia,261E1@186807|Peptococcaceae	186801|Clostridia	S	Protein of unknown function DUF89	-	-	-	ko:K09116	-	-	-	-	ko00000	-	-	-	DUF89
REGS1_k127_6003397_3	96561.Dole_1427	3.262e-58	207.0	COG0041@1|root,COG0151@1|root,COG0041@2|Bacteria,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,42MCI@68525|delta/epsilon subdivisions,2WJ7H@28221|Deltaproteobacteria,2MIPF@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC,GARS_A,GARS_C,GARS_N
REGS1_k127_6003397_0	289376.THEYE_A1245	1.379e-185	591.0	COG0151@1|root,COG0151@2|Bacteria,3J0H5@40117|Nitrospirae	40117|Nitrospirae	F	Phosphoribosylglycinamide synthetase, C domain	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
REGS1_k127_6003397_9	1123376.AUIU01000011_gene1072	9.978e-25	108.0	COG2003@1|root,COG2003@2|Bacteria,3J0HV@40117|Nitrospirae	40117|Nitrospirae	E	RadC-like JAB domain	-	-	-	ko:K03630	-	-	-	-	ko00000	-	-	-	RadC
REGS1_k127_6003397_1	1304885.AUEY01000014_gene3352	1.007e-97	332.0	COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,42MH9@68525|delta/epsilon subdivisions,2WJE0@28221|Deltaproteobacteria,2MIYV@213118|Desulfobacterales	28221|Deltaproteobacteria	NU	Type II secretion system (T2SS), protein F	-	-	-	ko:K02455	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSF
REGS1_k127_6003397_5	335543.Sfum_0102	2.548e-50	182.0	COG2165@1|root,COG2165@2|Bacteria,1RDX2@1224|Proteobacteria,42SFB@68525|delta/epsilon subdivisions,2WP3B@28221|Deltaproteobacteria,2MS2E@213462|Syntrophobacterales	28221|Deltaproteobacteria	U	PFAM type II secretion system protein G	gspG	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSG
REGS1_k127_6003397_12	671143.DAMO_2485	3.408e-12	72.0	COG4967@1|root,COG4967@2|Bacteria	2|Bacteria	NU	type IV pilus modification protein PilV	-	-	-	ko:K02458	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl
REGS1_k127_6003397_14	177437.HRM2_30160	6.302e-06	56.0	COG4966@1|root,COG4966@2|Bacteria,1QEE6@1224|Proteobacteria,433H9@68525|delta/epsilon subdivisions,2WY1D@28221|Deltaproteobacteria,2MPCI@213118|Desulfobacterales	28221|Deltaproteobacteria	NU	pilus assembly protein PilW	-	-	-	ko:K02459	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	-
REGS1_k127_6003397_8	269799.Gmet_0353	2.444e-27	124.0	COG2067@1|root,COG2067@2|Bacteria,1RFDS@1224|Proteobacteria,42UMQ@68525|delta/epsilon subdivisions,2WQY1@28221|Deltaproteobacteria,43TT0@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	Protein of unknown function (DUF3187)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3187
REGS1_k127_6009200_0	706587.Desti_4488	1.934e-102	347.0	COG1641@1|root,COG1641@2|Bacteria,1MUKU@1224|Proteobacteria,42MHQ@68525|delta/epsilon subdivisions,2WJAC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Belongs to the LarC family	-	-	4.99.1.12	ko:K09121	-	-	-	-	ko00000,ko01000	-	-	-	DUF111
REGS1_k127_6016380_3	289376.THEYE_A1747	1.548e-61	215.0	COG0492@1|root,COG0492@2|Bacteria,3J0M0@40117|Nitrospirae	40117|Nitrospirae	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_3
REGS1_k127_6016380_0	289376.THEYE_A1745	1.214e-148	478.0	COG1060@1|root,COG1060@2|Bacteria	2|Bacteria	H	7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase activity	mqnC	GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016765,GO:0044237,GO:0044249,GO:0044689,GO:0051186,GO:0051188	1.21.98.1,2.5.1.120,2.5.1.77	ko:K11779,ko:K11780,ko:K11781,ko:K11784,ko:K18285	ko00130,ko00680,ko01110,ko01120,map00130,map00680,map01110,map01120	M00378	R08588,R09396,R10667	RC00021,RC01381,RC02329,RC03002,RC03007,RC03234	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
REGS1_k127_6016380_1	289376.THEYE_A1742	7.946e-146	469.0	COG1060@1|root,COG1060@2|Bacteria	2|Bacteria	H	7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase activity	mqnE	GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016765,GO:0044237,GO:0044249,GO:0044689,GO:0051186,GO:0051188	1.21.98.1,2.5.1.120,2.5.1.77	ko:K11779,ko:K11780,ko:K11781,ko:K11784,ko:K18285	ko00130,ko00680,ko01110,ko01120,map00130,map00680,map01110,map01120	M00378	R08588,R09396,R10667	RC00021,RC01381,RC02329,RC03002,RC03007,RC03234	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_3391	Radical_SAM
REGS1_k127_6016380_8	1123376.AUIU01000011_gene1026	2.969e-27	114.0	COG0360@1|root,COG0360@2|Bacteria	2|Bacteria	J	Binds together with S18 to 16S ribosomal RNA	rpsF	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0097159,GO:1901363,GO:1990904	-	ko:K02990	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S6
REGS1_k127_6016380_5	289376.THEYE_A0794	1.733e-45	169.0	COG0629@1|root,COG0629@2|Bacteria,3J0NB@40117|Nitrospirae	40117|Nitrospirae	L	Single-strand binding protein family	-	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
REGS1_k127_6016380_10	289376.THEYE_A0795	6.59e-24	102.0	COG0238@1|root,COG0238@2|Bacteria,3J1F7@40117|Nitrospirae	40117|Nitrospirae	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit	rpsR	-	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
REGS1_k127_6016380_9	1123376.AUIU01000011_gene1029	1.52e-24	106.0	COG2952@1|root,COG2952@2|Bacteria,3J1ED@40117|Nitrospirae	40117|Nitrospirae	S	Protein of unknown function (DUF507)	-	-	-	-	-	-	-	-	-	-	-	-	DUF507
REGS1_k127_6016380_7	289376.THEYE_A0797	2.842e-27	113.0	COG2952@1|root,COG2952@2|Bacteria,3J1DP@40117|Nitrospirae	40117|Nitrospirae	S	Protein of unknown function (DUF507)	-	-	-	-	-	-	-	-	-	-	-	-	DUF507
REGS1_k127_6016380_4	378806.STAUR_4188	7.23e-61	234.0	COG2199@1|root,COG2203@1|root,COG2203@2|Bacteria,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,42PVX@68525|delta/epsilon subdivisions,2WPGK@28221|Deltaproteobacteria,2YTYN@29|Myxococcales	28221|Deltaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,GGDEF
REGS1_k127_6016380_6	404380.Gbem_2452	1.039e-40	156.0	COG1403@1|root,COG1403@2|Bacteria,1MWEQ@1224|Proteobacteria,42U6P@68525|delta/epsilon subdivisions,2WQ00@28221|Deltaproteobacteria,43V75@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	SMART HNH nuclease	-	-	-	ko:K07451	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HNH_5
REGS1_k127_6016380_2	1123376.AUIU01000011_gene1071	3.044e-102	343.0	COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,3J0AI@40117|Nitrospirae	40117|Nitrospirae	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
REGS1_k127_6034061_1	1123371.ATXH01000001_gene1241	1.045e-127	415.0	COG0730@1|root,COG0730@2|Bacteria,2GI6P@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
REGS1_k127_6034061_0	289376.THEYE_A0743	4.343e-134	440.0	COG2204@1|root,COG2204@2|Bacteria,3J10B@40117|Nitrospirae	40117|Nitrospirae	T	Sigma-54 interaction domain	-	-	-	ko:K07714	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
REGS1_k127_6034061_2	667014.Thein_2063	1.062e-57	208.0	COG4191@1|root,COG4191@2|Bacteria,2GIGP@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
REGS1_k127_6042542_0	247490.KSU1_C0356	1.846e-182	581.0	COG1109@1|root,COG1109@2|Bacteria	2|Bacteria	G	phosphoglucosamine mutase activity	femD	-	5.4.2.2,5.4.2.8	ko:K01835,ko:K01840	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114,M00549	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
REGS1_k127_6042542_1	443143.GM18_3296	1.466e-70	248.0	arCOG03165@1|root,30AIC@2|Bacteria,1QYWT@1224|Proteobacteria,43CDP@68525|delta/epsilon subdivisions,2X7PJ@28221|Deltaproteobacteria,43V63@69541|Desulfuromonadales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_6042542_2	485916.Dtox_0166	1.409e-12	69.0	COG1826@1|root,COG1826@2|Bacteria,1TV3X@1239|Firmicutes,259BA@186801|Clostridia,2639X@186807|Peptococcaceae	186801|Clostridia	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	tatA	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
REGS1_k127_6089948_0	243231.GSU3089	6.844e-117	395.0	COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,42N2S@68525|delta/epsilon subdivisions,2WJ0E@28221|Deltaproteobacteria,43U19@69541|Desulfuromonadales	28221|Deltaproteobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	rpoD	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
REGS1_k127_6089948_1	269799.Gmet_0138	1.275e-104	345.0	COG5316@1|root,COG5316@2|Bacteria,1QCVP@1224|Proteobacteria,42QA4@68525|delta/epsilon subdivisions,2WKD1@28221|Deltaproteobacteria,43SDE@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4139)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4139,DUF4140
REGS1_k127_6108708_2	330214.NIDE4308	1.498e-31	128.0	COG0824@1|root,COG0824@2|Bacteria,3J1EV@40117|Nitrospirae	40117|Nitrospirae	S	Thioesterase-like superfamily	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT
REGS1_k127_6108708_1	639282.DEFDS_0124	1.287e-106	356.0	COG0750@1|root,COG0750@2|Bacteria,2GEXF@200930|Deferribacteres	200930|Deferribacteres	M	Peptidase family M50	-	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_M50
REGS1_k127_6108708_0	1292035.H476_0869	8.86e-134	436.0	COG0743@1|root,COG0743@2|Bacteria,1TP1C@1239|Firmicutes,2483M@186801|Clostridia,25QE4@186804|Peptostreptococcaceae	186801|Clostridia	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	-	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS06420	DXPR_C,DXP_redisom_C,DXP_reductoisom
REGS1_k127_6108708_3	340177.Cag_1470	5.387e-22	97.0	COG4589@1|root,COG4589@2|Bacteria,1FE1V@1090|Chlorobi	1090|Chlorobi	M	Belongs to the CDS family	-	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
REGS1_k127_6108719_2	289376.THEYE_A0249	6.38e-68	240.0	COG4198@1|root,COG4198@2|Bacteria,3J0IE@40117|Nitrospirae	40117|Nitrospirae	S	Protein of unknown function (DUF1015)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1015
REGS1_k127_6108719_1	1232410.KI421413_gene533	3.05e-147	472.0	COG0057@1|root,COG0057@2|Bacteria,1MU93@1224|Proteobacteria,42N9Q@68525|delta/epsilon subdivisions,2WIK1@28221|Deltaproteobacteria,43S9H@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	gapA	-	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
REGS1_k127_6108719_0	289376.THEYE_A0247	4.106e-201	632.0	COG0126@1|root,COG0126@2|Bacteria,3J0DE@40117|Nitrospirae	40117|Nitrospirae	G	Phosphoglycerate kinase	pgk	-	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
REGS1_k127_6108719_3	1123376.AUIU01000013_gene1779	7.658e-48	172.0	COG1586@1|root,COG1586@2|Bacteria,3J15H@40117|Nitrospirae	40117|Nitrospirae	F	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine	speH	-	4.1.1.50	ko:K01611	ko00270,ko00330,ko01100,map00270,map00330,map01100	M00034,M00133	R00178	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	AdoMet_dc
REGS1_k127_6108861_10	289376.THEYE_A1438	1.589e-14	76.0	COG0255@1|root,COG0255@2|Bacteria	2|Bacteria	J	Belongs to the universal ribosomal protein uL29 family	rpmC	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
REGS1_k127_6108861_3	289376.THEYE_A1439	1.842e-67	231.0	COG0197@1|root,COG0197@2|Bacteria,3J0H7@40117|Nitrospirae	40117|Nitrospirae	J	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs	rplP	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904	-	ko:K02878	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
REGS1_k127_6108861_1	289376.THEYE_A1440	6.083e-102	335.0	COG0092@1|root,COG0092@2|Bacteria,3J0AP@40117|Nitrospirae	40117|Nitrospirae	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
REGS1_k127_6108861_7	1123376.AUIU01000005_gene1203	1.141e-35	138.0	COG0091@1|root,COG0091@2|Bacteria,3J0RZ@40117|Nitrospirae	40117|Nitrospirae	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rplV	-	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
REGS1_k127_6108861_6	289376.THEYE_A1442	4.475e-40	150.0	COG0185@1|root,COG0185@2|Bacteria,3J0MU@40117|Nitrospirae	40117|Nitrospirae	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rpsS	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
REGS1_k127_6108861_0	335543.Sfum_1558	6.046e-114	373.0	COG0090@1|root,COG0090@2|Bacteria,1MVTD@1224|Proteobacteria,42MBV@68525|delta/epsilon subdivisions,2WIRE@28221|Deltaproteobacteria,2MR4Z@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
REGS1_k127_6108861_8	289376.THEYE_A1444	1.022e-21	97.0	COG0089@1|root,COG0089@2|Bacteria,3J0TP@40117|Nitrospirae	40117|Nitrospirae	J	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome	rplW	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
REGS1_k127_6108861_4	935948.KE386495_gene1511	6.188e-66	231.0	COG0088@1|root,COG0088@2|Bacteria,1TPGW@1239|Firmicutes,248SY@186801|Clostridia,42ERX@68295|Thermoanaerobacterales	186801|Clostridia	J	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome	rplD	-	-	ko:K02926	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
REGS1_k127_6108861_2	1123376.AUIU01000005_gene1198	8.942e-86	289.0	COG0087@1|root,COG0087@2|Bacteria,3J0HP@40117|Nitrospirae	40117|Nitrospirae	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
REGS1_k127_6108861_5	272568.GDI3405	7.282e-46	168.0	COG0051@1|root,COG0051@2|Bacteria,1RGWF@1224|Proteobacteria,2U95D@28211|Alphaproteobacteria,2JST1@204441|Rhodospirillales	204441|Rhodospirillales	J	Involved in the binding of tRNA to the ribosomes	rpsJ	-	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
REGS1_k127_6108861_9	671143.DAMO_0537	2.66e-18	84.0	COG0050@1|root,COG0050@2|Bacteria,2NNQV@2323|unclassified Bacteria	2|Bacteria	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
REGS1_k127_6120788_0	1131269.AQVV01000020_gene2212	1.382e-193	616.0	COG1615@1|root,COG1615@2|Bacteria	2|Bacteria	S	Uncharacterised protein family (UPF0182)	-	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K09118	-	-	-	-	ko00000	-	-	-	UPF0182
REGS1_k127_6120788_4	78245.Xaut_3221	6.689e-65	229.0	COG0120@1|root,COG0120@2|Bacteria,1MVGR@1224|Proteobacteria,2TU68@28211|Alphaproteobacteria,3EYPQ@335928|Xanthobacteraceae	28211|Alphaproteobacteria	G	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate	rpiA	-	5.3.1.6	ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167,M00580	R01056	RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	Rib_5-P_isom_A
REGS1_k127_6120788_5	868595.Desca_1876	7.654e-45	165.0	COG0537@1|root,COG0537@2|Bacteria,1V9ZJ@1239|Firmicutes,24JCW@186801|Clostridia,262CU@186807|Peptococcaceae	186801|Clostridia	FG	PFAM Histidine triad (HIT) protein	hinT	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
REGS1_k127_6120788_7	697282.Mettu_1668	4.475e-26	110.0	COG0140@1|root,COG0140@2|Bacteria,1MZEE@1224|Proteobacteria,1S8R4@1236|Gammaproteobacteria,1XF9W@135618|Methylococcales	135618|Methylococcales	E	PFAM Phosphoribosyl-ATP pyrophosphohydrolase	hisE	GO:0000105,GO:0003674,GO:0003824,GO:0004636,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	3.6.1.31	ko:K01523	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-PH
REGS1_k127_6120788_6	926692.AZYG01000097_gene2348	1.1e-44	164.0	COG0139@1|root,COG0140@1|root,COG0139@2|Bacteria,COG0140@2|Bacteria,1UYNA@1239|Firmicutes,247RS@186801|Clostridia,3WANP@53433|Halanaerobiales	186801|Clostridia	E	Histidine biosynthesis bifunctional protein HisIE	hisI	-	3.5.4.19,3.6.1.31	ko:K01496,ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035,R04037	RC00002,RC01055	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS05760	His_biosynth,PRA-CH,PRA-PH
REGS1_k127_6120788_3	243231.GSU1185	2.299e-77	263.0	COG1839@1|root,COG1839@2|Bacteria,1RBCB@1224|Proteobacteria,42S44@68525|delta/epsilon subdivisions,2WMAS@28221|Deltaproteobacteria,43UGI@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Adenosine specific kinase	-	-	-	ko:K09129	-	-	-	-	ko00000	-	-	-	Adenosine_kin
REGS1_k127_6120788_2	289376.THEYE_A1378	4.458e-152	504.0	COG5000@1|root,COG5000@2|Bacteria,3J0B7@40117|Nitrospirae	40117|Nitrospirae	T	GHKL domain	-	-	2.7.13.3	ko:K13598	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS
REGS1_k127_6120788_1	1123376.AUIU01000001_gene779	2.129e-159	512.0	COG2204@1|root,COG2204@2|Bacteria,3J0C2@40117|Nitrospirae	40117|Nitrospirae	T	Bacterial regulatory protein, Fis family	-	-	-	ko:K13599	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
REGS1_k127_6124397_14	1235792.C808_04370	1.664e-25	107.0	COG0186@1|root,COG0186@2|Bacteria,1V9YC@1239|Firmicutes,24MSW@186801|Clostridia,27NW5@186928|unclassified Lachnospiraceae	186801|Clostridia	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rpsQ	-	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
REGS1_k127_6124397_6	289376.THEYE_A1436	1.074e-58	205.0	COG0093@1|root,COG0093@2|Bacteria,3J0JD@40117|Nitrospirae	40117|Nitrospirae	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rplN	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0097159,GO:1901363,GO:1990904	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
REGS1_k127_6124397_12	289376.THEYE_A1435	3.308e-33	134.0	COG0198@1|root,COG0198@2|Bacteria,3J0VK@40117|Nitrospirae	40117|Nitrospirae	J	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit	rplX	-	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,ribosomal_L24
REGS1_k127_6124397_2	1123376.AUIU01000005_gene1210	5.554e-83	278.0	COG0094@1|root,COG0094@2|Bacteria,3J0HN@40117|Nitrospirae	40117|Nitrospirae	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rplE	-	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
REGS1_k127_6124397_13	944481.JAFP01000001_gene1466	6.812e-26	107.0	COG0199@1|root,COG0199@2|Bacteria,1PDMJ@1224|Proteobacteria,42VCE@68525|delta/epsilon subdivisions,2WR7W@28221|Deltaproteobacteria,2M7GG@213113|Desulfurellales	28221|Deltaproteobacteria	J	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site	rpsN	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
REGS1_k127_6124397_7	289376.THEYE_A1432	3.858e-56	198.0	COG0096@1|root,COG0096@2|Bacteria,3J0SJ@40117|Nitrospirae	40117|Nitrospirae	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rpsH	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
REGS1_k127_6124397_3	289376.THEYE_A1431	3.428e-67	233.0	COG0097@1|root,COG0097@2|Bacteria,3J0JB@40117|Nitrospirae	40117|Nitrospirae	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rplF	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
REGS1_k127_6124397_10	498761.HM1_1394	5.833e-38	145.0	COG0256@1|root,COG0256@2|Bacteria,1V6DM@1239|Firmicutes,24JCS@186801|Clostridia	186801|Clostridia	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rplR	-	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18p
REGS1_k127_6124397_4	1123376.AUIU01000005_gene1214	1.179e-61	216.0	COG0098@1|root,COG0098@2|Bacteria,3J0M3@40117|Nitrospirae	40117|Nitrospirae	J	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body	rpsE	-	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
REGS1_k127_6124397_16	1122216.AUHW01000005_gene480	5.207e-10	62.0	COG1841@1|root,COG1841@2|Bacteria,1VEG4@1239|Firmicutes,4H5JF@909932|Negativicutes	909932|Negativicutes	J	Ribosomal protein L30	rpmD	-	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
REGS1_k127_6124397_8	555079.Toce_0137	1.871e-52	188.0	COG0200@1|root,COG0200@2|Bacteria,1V3KE@1239|Firmicutes,24HAJ@186801|Clostridia,42G84@68295|Thermoanaerobacterales	186801|Clostridia	J	Binds to the 23S rRNA	rplO	-	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
REGS1_k127_6124397_0	289376.THEYE_A1427	2.133e-213	669.0	COG0201@1|root,COG0201@2|Bacteria,3J0C0@40117|Nitrospirae	40117|Nitrospirae	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
REGS1_k127_6124397_1	1120985.AUMI01000006_gene2203	1.019e-98	327.0	COG0024@1|root,COG0024@2|Bacteria,1TQC1@1239|Firmicutes,4H2VZ@909932|Negativicutes	909932|Negativicutes	E	Methionine aminopeptidase	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
REGS1_k127_6124397_11	1347368.HG964409_gene7369	2.211e-35	135.0	COG0361@1|root,COG0361@2|Bacteria,1V9ZK@1239|Firmicutes,4HKF4@91061|Bacilli,1ZHWN@1386|Bacillus	91061|Bacilli	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	GO:0001871,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0009986,GO:0030246,GO:0030247,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:2001065	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
REGS1_k127_6124397_15	1280668.ATVT01000003_gene2508	1.24e-15	76.0	COG0257@1|root,COG0257@2|Bacteria,1VK4F@1239|Firmicutes,24UGF@186801|Clostridia,4C0FI@830|Butyrivibrio	186801|Clostridia	J	Ribosomal protein L36	rpmJ	-	-	ko:K02919	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L36
REGS1_k127_6124397_9	935948.KE386495_gene1487	2.399e-49	178.0	COG0099@1|root,COG0099@2|Bacteria,1V3JH@1239|Firmicutes,24HCT@186801|Clostridia,42G97@68295|Thermoanaerobacterales	186801|Clostridia	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	-	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
REGS1_k127_6124397_5	289376.THEYE_A1423	4.162e-59	206.0	COG0100@1|root,COG0100@2|Bacteria,3J0KE@40117|Nitrospirae	40117|Nitrospirae	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome	rpsK	-	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
REGS1_k127_6124397_17	338963.Pcar_0727	2.465e-06	49.0	COG0522@1|root,COG0522@2|Bacteria,1MW0U@1224|Proteobacteria,42M5X@68525|delta/epsilon subdivisions,2WJGN@28221|Deltaproteobacteria,43SEI@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Ribosomal protein S4/S9 N-terminal domain	rpsD	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
REGS1_k127_6139845_2	1123376.AUIU01000013_gene1881	1.857e-27	113.0	COG0054@1|root,COG0054@2|Bacteria,3J0QT@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
REGS1_k127_6139845_0	1123376.AUIU01000007_gene1178	1.388e-193	612.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,3J0E0@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribBA	-	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2
REGS1_k127_6139845_1	289376.THEYE_A0097	1.628e-57	206.0	COG0307@1|root,COG0307@2|Bacteria,3J0PR@40117|Nitrospirae	40117|Nitrospirae	H	Lumazine binding domain	ribE	-	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	Lum_binding
REGS1_k127_6139845_3	1304885.AUEY01000013_gene3080	4.165e-07	51.0	COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,42NJE@68525|delta/epsilon subdivisions,2WKMA@28221|Deltaproteobacteria,2MIAI@213118|Desulfobacterales	28221|Deltaproteobacteria	U	Belongs to the peptidase S26 family	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
REGS1_k127_6151386_2	69279.BG36_02925	2.927e-21	101.0	COG1765@1|root,COG1765@2|Bacteria,1MWPR@1224|Proteobacteria,2U1VW@28211|Alphaproteobacteria,43RI2@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
REGS1_k127_6151386_4	706587.Desti_1495	0.0002688	48.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K02481,ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
REGS1_k127_6151386_0	589924.Ferp_1758	1.012e-91	314.0	COG0407@1|root,arCOG03323@2157|Archaea,2XV21@28890|Euryarchaeota	28890|Euryarchaeota	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	hemE	-	2.1.1.246,4.1.1.37	ko:K01599,ko:K14080	ko00680,ko00860,ko01100,ko01110,ko01120,ko01200,map00680,map00860,map01100,map01110,map01120,map01200	M00121,M00356	R03197,R04972,R09098,R10000	RC00035,RC00872,RC01144,RC02440	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
REGS1_k127_6151386_1	589924.Ferp_1757	1.985e-40	155.0	COG0599@1|root,arCOG02148@2157|Archaea	2157|Archaea	S	PFAM Carboxymuconolactone decarboxylase	-	-	-	-	-	-	-	-	-	-	-	-	CMD
REGS1_k127_6151386_3	635013.TherJR_0981	2.665e-09	61.0	COG1962@1|root,COG1962@2|Bacteria,1UYYD@1239|Firmicutes,24AC2@186801|Clostridia,26150@186807|Peptococcaceae	186801|Clostridia	H	Tetrahydromethanopterin S-methyltransferase MtrH subunit	-	-	2.1.1.86	ko:K00584	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00357,M00567	R04347	RC00035,RC00113,RC02892	ko00000,ko00001,ko00002,ko01000	-	-	-	MtrH
REGS1_k127_6151690_4	1173029.JH980292_gene2839	2.431e-39	148.0	COG3657@1|root,COG3657@2|Bacteria,1G6YT@1117|Cyanobacteria,1HCJV@1150|Oscillatoriales	1117|Cyanobacteria	S	Phage derived protein Gp49-like (DUF891)	-	-	-	-	-	-	-	-	-	-	-	-	Gp49
REGS1_k127_6151690_6	1162668.LFE_0136	3.468e-38	145.0	COG3636@1|root,COG3636@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_6151690_2	330214.NIDE2578	1.721e-66	237.0	2F9RH@1|root,3421I@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_6151690_5	255470.cbdbA627	2.436e-38	160.0	COG0036@1|root,COG0036@2|Bacteria,2G6EU@200795|Chloroflexi,34D4E@301297|Dehalococcoidia	301297|Dehalococcoidia	G	Ribulose-phosphate 3 epimerase family	-	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
REGS1_k127_6151690_3	1183438.GKIL_4241	2.335e-51	199.0	COG0363@1|root,COG0363@2|Bacteria,1G20H@1117|Cyanobacteria	1117|Cyanobacteria	G	6-phosphogluconolactonase	pgl	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009051,GO:0009117,GO:0009987,GO:0016787,GO:0016788,GO:0017057,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0052689,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564	3.1.1.31	ko:K01057	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R02035	RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucosamine_iso
REGS1_k127_6151690_1	596151.DesfrDRAFT_3924	5.213e-110	362.0	COG0176@1|root,COG0176@2|Bacteria,1MWQ8@1224|Proteobacteria,42M39@68525|delta/epsilon subdivisions,2WJEZ@28221|Deltaproteobacteria,2M90T@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	-	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
REGS1_k127_6151690_0	289376.THEYE_A0954	1.083e-204	647.0	COG0021@1|root,COG0021@2|Bacteria,3J0MM@40117|Nitrospirae	40117|Nitrospirae	G	Transketolase, pyrimidine binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
REGS1_k127_6160421_3	316067.Geob_3384	4.892e-93	329.0	COG0840@1|root,COG1511@1|root,COG0840@2|Bacteria,COG1511@2|Bacteria,1MU9B@1224|Proteobacteria,42M22@68525|delta/epsilon subdivisions,2WM8F@28221|Deltaproteobacteria	28221|Deltaproteobacteria	NT	Chemotaxis sensory transducer	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,HAMP,MCPsignal,PAS_4,dCache_1
REGS1_k127_6160421_7	316067.Geob_3385	2.021e-38	153.0	COG0835@1|root,COG0835@2|Bacteria,1RAH1@1224|Proteobacteria,42QS2@68525|delta/epsilon subdivisions,2WMXG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	NT	PFAM CheW domain protein	-	-	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
REGS1_k127_6160421_2	744872.Spica_0958	6.35e-98	340.0	COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,2J5F4@203691|Spirochaetes	203691|Spirochaetes	NT	chemotaxis protein	cheA	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,P2
REGS1_k127_6160421_6	316067.Geob_3387	1.082e-40	157.0	COG0745@1|root,COG0745@2|Bacteria,1R9AR@1224|Proteobacteria,42YHD@68525|delta/epsilon subdivisions,2WU58@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	cheY-homologous receiver domain	-	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
REGS1_k127_6160421_8	316067.Geob_3388	3.986e-31	128.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	DUF4388,GGDEF,Response_reg
REGS1_k127_6160421_1	1123371.ATXH01000019_gene586	7.565e-116	387.0	COG2204@1|root,COG2204@2|Bacteria,2GH1I@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	T	Bacterial regulatory protein, Fis family	-	-	-	ko:K13599	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
REGS1_k127_6160421_5	483219.LILAB_31775	1.098e-54	195.0	COG1327@1|root,COG1327@2|Bacteria,1RE7V@1224|Proteobacteria,42SJP@68525|delta/epsilon subdivisions,2WPK0@28221|Deltaproteobacteria,2YVAV@29|Myxococcales	28221|Deltaproteobacteria	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	-	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
REGS1_k127_6160421_0	857293.CAAU_2589	9.198e-178	565.0	COG0112@1|root,COG0112@2|Bacteria,1TQVM@1239|Firmicutes,248W5@186801|Clostridia,36EMY@31979|Clostridiaceae	186801|Clostridia	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
REGS1_k127_6160421_4	289376.THEYE_A1386	2.391e-58	205.0	COG0698@1|root,COG0698@2|Bacteria,3J14S@40117|Nitrospirae	40117|Nitrospirae	G	Ribose/Galactose Isomerase	-	-	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	LacAB_rpiB
REGS1_k127_6176356_4	1122201.AUAZ01000023_gene3051	4.064e-08	62.0	COG1075@1|root,COG1075@2|Bacteria,1N2W0@1224|Proteobacteria,1SAMR@1236|Gammaproteobacteria,46CGJ@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	PGAP1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6,PGAP1
REGS1_k127_6176356_3	1123376.AUIU01000014_gene616	1.328e-27	112.0	2EK9R@1|root,33E01@2|Bacteria,3J1B5@40117|Nitrospirae	40117|Nitrospirae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_6176356_2	857087.Metme_3902	1.608e-62	217.0	COG0784@1|root,COG0784@2|Bacteria,1QUN7@1224|Proteobacteria,1T3Z8@1236|Gammaproteobacteria,1XGIJ@135618|Methylococcales	135618|Methylococcales	T	SMART Signal transduction response regulator, receiver region	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
REGS1_k127_6176356_1	309798.COPRO5265_0030	7.185e-79	302.0	COG3829@1|root,COG4251@1|root,COG3829@2|Bacteria,COG4251@2|Bacteria,1V0TU@1239|Firmicutes,24FNP@186801|Clostridia,42I3Z@68295|Thermoanaerobacterales	186801|Clostridia	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_9
REGS1_k127_6176356_0	443143.GM18_4017	0.0	2293.0	COG0515@1|root,COG2203@1|root,COG3899@1|root,COG0515@2|Bacteria,COG2203@2|Bacteria,COG3899@2|Bacteria,1RGKE@1224|Proteobacteria,43DX3@68525|delta/epsilon subdivisions,2X71G@28221|Deltaproteobacteria	28221|Deltaproteobacteria	KLT	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GAF,GAF_2,HATPase_c,HisKA_3,Pkinase,STAS
REGS1_k127_6222934_2	243233.MCA1752	3.364e-161	515.0	COG2373@1|root,COG2373@2|Bacteria,1MV7J@1224|Proteobacteria,1RNRY@1236|Gammaproteobacteria,1XFSK@135618|Methylococcales	135618|Methylococcales	S	Alpha-2-Macroglobulin	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,MG1
REGS1_k127_6222934_0	909663.KI867149_gene3353	8.778e-232	738.0	COG4953@1|root,COG4953@2|Bacteria,1MUA9@1224|Proteobacteria,42MSV@68525|delta/epsilon subdivisions,2WJ6U@28221|Deltaproteobacteria,2MQCS@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Penicillin-Binding Protein C-terminus Family	pbp2	-	2.4.1.129	ko:K05367	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	BiPBP_C,Transgly,Transpeptidase
REGS1_k127_6222934_1	289376.THEYE_A0790	3.186e-170	542.0	COG0014@1|root,COG0014@2|Bacteria,3J0ET@40117|Nitrospirae	40117|Nitrospirae	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate	proA	GO:0003674,GO:0003824,GO:0004350,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
REGS1_k127_6231089_5	396588.Tgr7_0628	4.005e-08	59.0	COG2026@1|root,COG2026@2|Bacteria,1NGC6@1224|Proteobacteria	1224|Proteobacteria	DJ	cytotoxic translational repressor of toxin-antitoxin	-	-	-	ko:K06218	-	-	-	-	ko00000,ko02048	-	-	-	ParE_toxin
REGS1_k127_6231089_4	979556.MTES_2116	1.27e-09	63.0	COG2161@1|root,COG2161@2|Bacteria,2GV08@201174|Actinobacteria,4FQEB@85023|Microbacteriaceae	201174|Actinobacteria	D	Antitoxin component of a toxin-antitoxin (TA) module	relB	GO:0003674,GO:0005488,GO:0005515,GO:0008150,GO:0040008,GO:0045927,GO:0048518,GO:0050789,GO:0065007,GO:0097351	-	ko:K19159	-	-	-	-	ko00000,ko02048	-	-	-	PhdYeFM_antitox
REGS1_k127_6231089_6	1121091.AUMP01000006_gene4105	4.005e-07	51.0	2DTBP@1|root,33JKJ@2|Bacteria,1VKDH@1239|Firmicutes,4I0AV@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_6231089_1	243231.GSU0038	5.484e-37	147.0	COG4765@1|root,COG4765@2|Bacteria,1N5MU@1224|Proteobacteria,42TQ6@68525|delta/epsilon subdivisions,2WR2C@28221|Deltaproteobacteria,43VB1@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2155)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2155
REGS1_k127_6231089_3	1322246.BN4_11865	7.154e-11	69.0	COG1633@1|root,COG1633@2|Bacteria,1N997@1224|Proteobacteria,42VKE@68525|delta/epsilon subdivisions,2WRKQ@28221|Deltaproteobacteria,2MC42@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
REGS1_k127_6231089_0	1499967.BAYZ01000080_gene951	6.594e-48	190.0	COG0642@1|root,COG2205@2|Bacteria,2NPIU@2323|unclassified Bacteria	2|Bacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,Response_reg
REGS1_k127_6250712_7	404589.Anae109_1476	6.783e-06	49.0	COG0784@1|root,COG0784@2|Bacteria,1QYG7@1224|Proteobacteria,43E8C@68525|delta/epsilon subdivisions,2X7NA@28221|Deltaproteobacteria,2Z11B@29|Myxococcales	28221|Deltaproteobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
REGS1_k127_6250712_6	1191523.MROS_1164	8.033e-08	55.0	COG2331@1|root,COG2331@2|Bacteria	2|Bacteria	P	Regulatory protein, FmdB family	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
REGS1_k127_6250712_0	56780.SYN_01240	8.923e-153	490.0	COG1180@1|root,COG1180@2|Bacteria,1NQC1@1224|Proteobacteria,42N7U@68525|delta/epsilon subdivisions,2WJ81@28221|Deltaproteobacteria,2MQ4H@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	PFAM Radical SAM	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
REGS1_k127_6250712_5	1345695.CLSA_c05710	1.205e-29	126.0	COG0454@1|root,COG0456@2|Bacteria,1V6KU@1239|Firmicutes,24J9Z@186801|Clostridia,36JIM@31979|Clostridiaceae	186801|Clostridia	K	This enzyme acetylates the N-terminal alanine of ribosomal protein S18	rimI	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1,Acetyltransf_10
REGS1_k127_6250712_4	1499967.BAYZ01000084_gene3996	6.575e-56	203.0	COG1214@1|root,COG1214@2|Bacteria,2NPK8@2323|unclassified Bacteria	2|Bacteria	O	Glycoprotease family	yeaZ	GO:0002949,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070011,GO:0070525,GO:0071704,GO:0090304,GO:0140096,GO:1901360,GO:1901564	2.3.1.234	ko:K01409,ko:K14742	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
REGS1_k127_6250712_1	760568.Desku_0392	3.513e-95	327.0	COG0477@1|root,COG2814@2|Bacteria,1TRUT@1239|Firmicutes,25E84@186801|Clostridia,260VE@186807|Peptococcaceae	186801|Clostridia	EGP	PFAM Bacterial protein of	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
REGS1_k127_6250712_2	880072.Desac_0142	4.51e-66	236.0	COG0803@1|root,COG0803@2|Bacteria,1MVW9@1224|Proteobacteria,42MBX@68525|delta/epsilon subdivisions,2WJYG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	PFAM periplasmic solute binding protein	-	-	-	ko:K09815	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ZnuA
REGS1_k127_6250712_3	1158345.JNLL01000001_gene1148	5.298e-60	219.0	COG1121@1|root,COG1121@2|Bacteria,2G4SK@200783|Aquificae	200783|Aquificae	P	ABC transporter	-	-	-	ko:K09817	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ABC_tran
REGS1_k127_6257845_1	1123376.AUIU01000016_gene303	7.301e-34	133.0	COG0536@1|root,COG0536@2|Bacteria,3J0E3@40117|Nitrospirae	40117|Nitrospirae	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	GTP1_OBG,MMR_HSR1
REGS1_k127_6257845_0	1232410.KI421412_gene395	3.235e-91	308.0	COG0263@1|root,COG0263@2|Bacteria,1MUBG@1224|Proteobacteria,42NEA@68525|delta/epsilon subdivisions,2WIVS@28221|Deltaproteobacteria,43T3Q@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase	proB	GO:0003674,GO:0003824,GO:0004349,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0018130,GO:0019202,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.11	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	M00015	R00239	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_3198	AA_kinase,PUA
REGS1_k127_6264293_0	289376.THEYE_A1980	5.154e-44	163.0	COG1674@1|root,COG1674@2|Bacteria,3J0BQ@40117|Nitrospirae	40117|Nitrospirae	D	Ftsk_gamma	ftsK	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
REGS1_k127_6264293_1	289376.THEYE_A1147	1.881e-39	154.0	COG2834@1|root,COG2834@2|Bacteria,3J1C6@40117|Nitrospirae	40117|Nitrospirae	M	Outer membrane lipoprotein carrier protein LolA	-	-	-	ko:K03634	-	-	-	-	ko00000	-	-	-	LolA
REGS1_k127_6264293_2	1499967.BAYZ01000100_gene3454	5.262e-14	82.0	2EVWS@1|root,33PAF@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_6286182_3	378806.STAUR_4245	2.174e-52	197.0	COG0451@1|root,COG0451@2|Bacteria,1MX2J@1224|Proteobacteria,42TZR@68525|delta/epsilon subdivisions,2WQAW@28221|Deltaproteobacteria,2YV9A@29|Myxococcales	28221|Deltaproteobacteria	M	NmrA-like family	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
REGS1_k127_6286182_0	289376.THEYE_A0594	6.099e-200	629.0	COG0156@1|root,COG0156@2|Bacteria,3J0XU@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide	-	-	2.3.1.29	ko:K00639	ko00260,map00260	-	R00371	RC00004,RC00394	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
REGS1_k127_6286182_1	289376.THEYE_A0577	9.13e-122	401.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
REGS1_k127_6286182_2	937774.TEQUI_1101	6.308e-103	348.0	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,2VI6I@28216|Betaproteobacteria,3T22E@506|Alcaligenaceae	28216|Betaproteobacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0016740,GO:0016746,GO:0016747,GO:0033817	2.3.1.179	ko:K00646,ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004,ko01008	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
REGS1_k127_6286182_4	246194.CHY_1163	8.888e-16	87.0	COG1426@1|root,COG1426@2|Bacteria,1V1N7@1239|Firmicutes,24M2Q@186801|Clostridia,42J4X@68295|Thermoanaerobacterales	186801|Clostridia	S	Domain of unknown function (DUF4115)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4115,HTH_25
REGS1_k127_6317080_0	204536.SULAZ_0355	3.168e-136	440.0	COG0399@1|root,COG0399@2|Bacteria,2G4VK@200783|Aquificae	200783|Aquificae	E	Cys/Met metabolism PLP-dependent enzyme	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
REGS1_k127_6317080_4	866895.HBHAL_4427	8.917e-54	202.0	COG4447@1|root,COG4447@2|Bacteria,1UKJF@1239|Firmicutes	1239|Firmicutes	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_6317080_2	222984.JNCS01000010_gene93	4.74e-130	426.0	COG0677@1|root,arCOG00252@2157|Archaea,2XUJT@28890|Euryarchaeota,23U0F@183963|Halobacteria	183963|Halobacteria	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	-	-	1.1.1.336	ko:K02472	ko00520,ko05111,map00520,map05111	-	R03317	RC00291	ko00000,ko00001,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
REGS1_k127_6317080_1	335541.Swol_0634	4.269e-134	434.0	COG0451@1|root,COG0451@2|Bacteria,1U9KB@1239|Firmicutes,24EDU@186801|Clostridia	186801|Clostridia	GM	PFAM NAD dependent epimerase dehydratase family	-	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
REGS1_k127_6317080_3	880073.Calab_0603	1.603e-77	274.0	COG0438@1|root,COG0438@2|Bacteria,2NQ20@2323|unclassified Bacteria	2|Bacteria	M	Glycosyl transferases group 1	-	-	-	ko:K00786	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
REGS1_k127_6317080_5	1123368.AUIS01000004_gene271	5.199e-23	109.0	COG1434@1|root,COG1434@2|Bacteria,1MVW8@1224|Proteobacteria,1RNZC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Gram-negative-bacterium-type cell wall biogenesis	ycbC	GO:0000270,GO:0005575,GO:0005623,GO:0005886,GO:0006022,GO:0006807,GO:0008150,GO:0008152,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0030203,GO:0031224,GO:0042546,GO:0043164,GO:0043170,GO:0044085,GO:0044425,GO:0044464,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901564	-	-	-	-	-	-	-	-	-	-	DUF218
REGS1_k127_6317080_6	420246.GTNG_2116	8.694e-19	91.0	COG0438@1|root,COG0438@2|Bacteria,1TPS8@1239|Firmicutes,4HA43@91061|Bacilli,1WE1P@129337|Geobacillus	91061|Bacilli	M	Glycosyl transferase 4-like	bshA	GO:0003674,GO:0003824,GO:0016740,GO:0016757	-	ko:K00754	-	-	-	-	ko00000,ko01000	-	GT4	-	Glyco_transf_4,Glycos_transf_1
REGS1_k127_6320120_8	868864.Dester_0316	3.169e-12	68.0	COG0548@1|root,COG0548@2|Bacteria,2G3SD@200783|Aquificae	200783|Aquificae	F	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
REGS1_k127_6320120_4	289376.THEYE_A1399	6.729e-68	235.0	COG2191@1|root,COG2191@2|Bacteria	2|Bacteria	C	Formylmethanofuran dehydrogenase, subunit e	fwdE	-	1.2.7.12	ko:K11261	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060,R11743	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	FmdE,zf-dskA_traR
REGS1_k127_6320120_6	316067.Geob_1085	1.433e-56	202.0	COG3012@1|root,COG3012@2|Bacteria,1MZZK@1224|Proteobacteria,42RE5@68525|delta/epsilon subdivisions,2WNNI@28221|Deltaproteobacteria,43V2V@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	SEC-C motif	-	-	-	ko:K09858	-	-	-	-	ko00000	-	-	-	SEC-C
REGS1_k127_6320120_5	1123376.AUIU01000001_gene800	6.127e-66	232.0	COG0797@1|root,COG3087@1|root,COG0797@2|Bacteria,COG3087@2|Bacteria,3J0PD@40117|Nitrospirae	40117|Nitrospirae	M	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	rlpA	-	-	ko:K03642	-	-	-	-	ko00000	-	-	-	DPBB_1,SPOR
REGS1_k127_6320120_0	289376.THEYE_A1397	1.587e-206	649.0	COG1220@1|root,COG1220@2|Bacteria,3J0XE@40117|Nitrospirae	40117|Nitrospirae	O	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis	hslU	-	-	ko:K03667	-	-	-	-	ko00000,ko03110	-	-	-	AAA_2,ClpB_D2-small
REGS1_k127_6320120_3	289376.THEYE_A1396	2.066e-82	277.0	COG5405@1|root,COG5405@2|Bacteria,3J10R@40117|Nitrospirae	40117|Nitrospirae	O	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery	hslV	-	3.4.25.2	ko:K01419	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Proteasome
REGS1_k127_6320120_2	289376.THEYE_A1395	1.266e-108	359.0	COG4974@1|root,COG4974@2|Bacteria,3J0PS@40117|Nitrospirae	40117|Nitrospirae	L	Phage integrase, N-terminal SAM-like domain	xerC	-	-	ko:K03733	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
REGS1_k127_6320120_1	243231.GSU2547	2.343e-155	501.0	COG1206@1|root,COG1206@2|Bacteria,1MWNQ@1224|Proteobacteria,42MTS@68525|delta/epsilon subdivisions,2WJ50@28221|Deltaproteobacteria,43T6Q@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs	trmFO	GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363	2.1.1.74	ko:K04094	-	-	-	-	ko00000,ko01000,ko03016,ko03036	-	-	-	GIDA
REGS1_k127_6320120_7	765420.OSCT_0770	8.906e-22	100.0	COG5295@1|root,COG5295@2|Bacteria,2GB82@200795|Chloroflexi,377IZ@32061|Chloroflexia	32061|Chloroflexia	UW	Hep Hag repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	Pectinesterase
REGS1_k127_6377161_0	243231.GSU2907	8.058e-240	756.0	COG0701@1|root,COG0701@2|Bacteria	2|Bacteria	S	Predicted permease	-	-	-	ko:K07089	-	-	-	-	ko00000	-	-	-	ArsP_1
REGS1_k127_6377161_2	1121918.ARWE01000001_gene1558	3.685e-104	353.0	COG2391@1|root,COG2391@2|Bacteria,1NCH7@1224|Proteobacteria,42NKG@68525|delta/epsilon subdivisions,2WJFC@28221|Deltaproteobacteria,43TGF@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Sulphur transport	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
REGS1_k127_6377161_7	1121918.ARWE01000001_gene1557	5.252e-08	61.0	COG0457@1|root,COG0457@2|Bacteria	1121918.ARWE01000001_gene1557|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_6377161_3	269799.Gmet_0568	6.206e-100	334.0	COG3221@1|root,COG3221@2|Bacteria,1NPBT@1224|Proteobacteria,42NX8@68525|delta/epsilon subdivisions,2X5DW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	ABC transporter, phosphonate, periplasmic substrate-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Phosphonate-bd
REGS1_k127_6377161_4	269799.Gmet_0562	3.786e-96	323.0	COG1333@1|root,COG1333@2|Bacteria	2|Bacteria	O	cytochrome c biogenesis protein	ccs1	-	-	ko:K07399	-	-	-	-	ko00000	-	-	-	ResB
REGS1_k127_6377161_6	316067.Geob_3355	6.931e-42	162.0	COG1732@1|root,COG1732@2|Bacteria	2|Bacteria	M	glycine betaine transport	yehZ	-	-	ko:K05845,ko:K05846	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	BPD_transp_1,OpuAC
REGS1_k127_6377161_1	269799.Gmet_0559	1.534e-137	452.0	COG3420@1|root,COG3420@2|Bacteria	2|Bacteria	P	alginic acid biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,NosD
REGS1_k127_6393909_1	1123376.AUIU01000016_gene331	7.308e-36	139.0	COG0193@1|root,COG0193@2|Bacteria,3J0QR@40117|Nitrospirae	40117|Nitrospirae	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	GO:0003674,GO:0003824,GO:0004045,GO:0016787,GO:0016788,GO:0052689,GO:0140098,GO:0140101	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
REGS1_k127_6393909_0	269799.Gmet_1948	7.672e-88	297.0	COG0149@1|root,COG0149@2|Bacteria,1MWK5@1224|Proteobacteria,42MIF@68525|delta/epsilon subdivisions,2WIQF@28221|Deltaproteobacteria,43T81@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	-	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
REGS1_k127_6399612_7	1125863.JAFN01000001_gene3430	2.166e-23	103.0	COG0640@1|root,COG0640@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	arsR	-	3.6.4.12	ko:K03655,ko:K03892,ko:K21903	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03000,ko03400	-	-	-	HTH_20,HTH_5
REGS1_k127_6399612_6	565033.GACE_0288	1.304e-38	148.0	COG1553@1|root,arCOG02068@2157|Archaea,2Y6XQ@28890|Euryarchaeota,2478Y@183980|Archaeoglobi	183980|Archaeoglobi	P	DsrE/DsrF-like family	-	-	-	ko:K06039	-	-	-	-	ko00000	-	-	-	DrsE
REGS1_k127_6399612_9	1259795.ARJK01000003_gene1182	0.0002535	46.0	COG1553@1|root,COG1553@2|Bacteria,1VG50@1239|Firmicutes,24R7R@186801|Clostridia,42H7U@68295|Thermoanaerobacterales	186801|Clostridia	P	DsrE/DsrF-like family	-	-	-	ko:K07235	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DrsE
REGS1_k127_6399612_10	269797.Mbar_A2151	0.0007563	48.0	arCOG02070@1|root,arCOG02070@2157|Archaea	269797.Mbar_A2151|-	S	DsrE/DsrF/DrsH-like family	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_6399612_8	2423.NA23_0201010	2.771e-08	59.0	COG2168@1|root,COG2168@2|Bacteria,2GDEY@200918|Thermotogae	200918|Thermotogae	P	sulfur relay protein TusB DsrH	-	-	-	ko:K07237	ko04122,map04122	-	-	-	ko00000,ko00001,ko03016	-	-	-	DsrH
REGS1_k127_6399612_1	589865.DaAHT2_2661	1.817e-146	474.0	COG0446@1|root,COG0446@2|Bacteria,1QSGB@1224|Proteobacteria,43A36@68525|delta/epsilon subdivisions,2WZXC@28221|Deltaproteobacteria,2MP72@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
REGS1_k127_6399612_0	1379698.RBG1_1C00001G0564	2.842e-294	921.0	COG1033@1|root,COG1033@2|Bacteria,2NQ2I@2323|unclassified Bacteria	2|Bacteria	S	MMPL family	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	LolA_like,MMPL
REGS1_k127_6399612_3	1379698.RBG1_1C00001G0565	4.664e-94	315.0	COG2834@1|root,COG2834@2|Bacteria,2NQJ8@2323|unclassified Bacteria	2|Bacteria	M	Outer membrane lipoprotein-sorting protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF4292,DUF4367,LolA_like
REGS1_k127_6399612_2	1379698.RBG1_1C00001G0567	1.486e-132	434.0	COG4773@1|root,COG4773@2|Bacteria	2|Bacteria	P	Receptor	-	-	-	-	-	-	-	-	-	-	-	-	Plug
REGS1_k127_6399612_4	429009.Adeg_0304	4.148e-93	316.0	COG0709@1|root,COG0709@2|Bacteria,1TQCJ@1239|Firmicutes,247NS@186801|Clostridia,42ENJ@68295|Thermoanaerobacterales	186801|Clostridia	F	Synthesizes selenophosphate from selenide and ATP	selD	-	2.7.9.3	ko:K01008	ko00450,ko01100,map00450,map01100	-	R03595	RC00002,RC02878	ko00000,ko00001,ko01000,ko03016	-	-	-	AIRS,AIRS_C
REGS1_k127_6399612_5	867903.ThesuDRAFT_02312	5.857e-61	219.0	COG0730@1|root,COG0730@2|Bacteria,1TRIE@1239|Firmicutes	1239|Firmicutes	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
REGS1_k127_6416824_1	243231.GSU1649	6.929e-75	257.0	COG1290@1|root,COG1290@2|Bacteria,1MV97@1224|Proteobacteria,42MD6@68525|delta/epsilon subdivisions,2WPA2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	cbcW	-	-	ko:K00412	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko03029	-	-	-	Cytochrom_B_C,Cytochrom_B_N_2,Cytochrom_C,Cytochrome_B,Cytochrome_CBB3
REGS1_k127_6416824_3	1121918.ARWE01000001_gene2160	1.039e-30	128.0	COG0723@1|root,COG0723@2|Bacteria,1RAA2@1224|Proteobacteria,42R5N@68525|delta/epsilon subdivisions,2X67B@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Rieske [2Fe-2S] domain	-	-	1.10.9.1	ko:K02636	ko00195,ko01100,map00195,map01100	M00162	R03817,R08409	RC01002	ko00000,ko00001,ko00002,ko00194,ko01000	-	-	-	Rieske
REGS1_k127_6416824_0	335543.Sfum_4019	3.922e-305	941.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,42MMK@68525|delta/epsilon subdivisions,2WJC1@28221|Deltaproteobacteria,2MSIG@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	ABC transporter	yjjK	-	3.6.3.25	ko:K06020	-	-	-	-	ko00000,ko01000	-	-	-	ABC_tran,ABC_tran_Xtn
REGS1_k127_6416824_2	1379698.RBG1_1C00001G1199	2.867e-61	224.0	COG3852@1|root,COG3852@2|Bacteria,2NS4D@2323|unclassified Bacteria	2|Bacteria	T	Signal transduction histidine kinase, nitrogen specific, NtrB	-	-	2.7.13.3	ko:K07708	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_9
REGS1_k127_6444200_3	891968.Anamo_1899	8.526e-18	83.0	COG1249@1|root,COG1249@2|Bacteria,3TAHW@508458|Synergistetes	508458|Synergistetes	C	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
REGS1_k127_6444200_1	289376.THEYE_A1007	2.646e-48	176.0	COG0509@1|root,COG0509@2|Bacteria,3J0SD@40117|Nitrospirae	40117|Nitrospirae	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
REGS1_k127_6444200_0	1123376.AUIU01000012_gene1332	1.025e-286	904.0	COG0249@1|root,COG0249@2|Bacteria,3J0CE@40117|Nitrospirae	40117|Nitrospirae	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
REGS1_k127_6444200_2	1123376.AUIU01000015_gene450	6.214e-42	159.0	COG1399@1|root,COG1399@2|Bacteria,3J0UQ@40117|Nitrospirae	40117|Nitrospirae	S	Uncharacterized ACR, COG1399	-	-	-	ko:K07040	-	-	-	-	ko00000	-	-	-	DUF177
REGS1_k127_6447788_0	404380.Gbem_3986	2.457e-154	496.0	COG0477@1|root,COG2814@2|Bacteria,1NE49@1224|Proteobacteria,42PR8@68525|delta/epsilon subdivisions,2WK8J@28221|Deltaproteobacteria	28221|Deltaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
REGS1_k127_6447788_2	443598.AUFA01000028_gene7138	2.065e-71	248.0	COG4275@1|root,COG4275@2|Bacteria,1MYDE@1224|Proteobacteria,2TV61@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Chromate resistance exported protein	-	-	-	-	-	-	-	-	-	-	-	-	Chrome_Resist
REGS1_k127_6447788_3	768670.Calni_1515	5.331e-37	143.0	COG2005@1|root,COG2005@2|Bacteria,2GG3A@200930|Deferribacteres	200930|Deferribacteres	K	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	ko:K02019	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,TOBE
REGS1_k127_6447788_1	1123376.AUIU01000015_gene360	7.792e-123	398.0	COG2998@1|root,COG2998@2|Bacteria	2|Bacteria	H	PBP superfamily domain	-	-	-	ko:K05772	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	PBP_like_2
REGS1_k127_6464462_0	1125863.JAFN01000001_gene674	1.298e-269	842.0	COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,42MFA@68525|delta/epsilon subdivisions,2WJ20@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
REGS1_k127_6500506_3	269799.Gmet_3232	8.743e-44	160.0	COG0755@1|root,COG0755@2|Bacteria,1RCCI@1224|Proteobacteria,42PVM@68525|delta/epsilon subdivisions,2WJ7I@28221|Deltaproteobacteria,43TXA@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	PFAM cytochrome c assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
REGS1_k127_6500506_0	1123376.AUIU01000019_gene1250	1.233e-138	452.0	COG0373@1|root,COG0373@2|Bacteria,3J0BD@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	-	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
REGS1_k127_6500506_1	1125863.JAFN01000001_gene1122	2.543e-116	383.0	COG0181@1|root,COG0181@2|Bacteria,1MU56@1224|Proteobacteria,42M84@68525|delta/epsilon subdivisions,2WJ5V@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	-	Porphobil_deam,Porphobil_deamC
REGS1_k127_6500506_2	398767.Glov_2376	1.141e-55	206.0	292MS@1|root,2ZQ5N@2|Bacteria,1N3H9@1224|Proteobacteria,43142@68525|delta/epsilon subdivisions,2WW78@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_6500506_8	387631.Asulf_00539	2.237e-11	69.0	COG4747@1|root,arCOG04444@2157|Archaea,2XXTI@28890|Euryarchaeota,24737@183980|Archaeoglobi	183980|Archaeoglobi	S	ACT domain	-	-	-	-	-	-	-	-	-	-	-	-	ACT
REGS1_k127_6500506_5	1499967.BAYZ01000079_gene888	1.969e-33	132.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	cNMP_binding
REGS1_k127_6500506_4	335541.Swol_2275	5.539e-38	146.0	COG3654@1|root,COG3654@2|Bacteria,1TTED@1239|Firmicutes,25MP6@186801|Clostridia,42KS7@68298|Syntrophomonadaceae	186801|Clostridia	S	Fic/DOC family	-	-	-	ko:K07341	-	-	-	-	ko00000,ko02048	-	-	-	Fic
REGS1_k127_6500506_6	671143.DAMO_2725	2.805e-21	94.0	COG2336@1|root,COG2336@2|Bacteria	2|Bacteria	T	PFAM SpoVT AbrB	-	-	-	ko:K07172,ko:K18842	-	-	-	-	ko00000,ko02048	-	-	-	MazE_antitoxin
REGS1_k127_6500506_7	1196028.ALEF01000031_gene1265	8.318e-20	94.0	COG5635@1|root,COG5635@2|Bacteria,1TR89@1239|Firmicutes,4HW38@91061|Bacilli	91061|Bacilli	T	Nacht domain	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_6539329_3	335543.Sfum_1244	2.892e-15	79.0	2CB8R@1|root,2Z90U@2|Bacteria,1R4DV@1224|Proteobacteria,42R2G@68525|delta/epsilon subdivisions,2WMQS@28221|Deltaproteobacteria,2MRR0@213462|Syntrophobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_6539329_2	398767.Glov_2045	1.097e-59	223.0	COG2206@1|root,COG2206@2|Bacteria,1RAQS@1224|Proteobacteria,42MEJ@68525|delta/epsilon subdivisions,2X71A@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	metal-dependent phosphohydrolase HD region	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,GAF_3,HAMP,HD,HD_5
REGS1_k127_6539329_0	289376.THEYE_A1817	1.114e-157	507.0	COG0141@1|root,COG0141@2|Bacteria,3J0C6@40117|Nitrospirae	40117|Nitrospirae	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	-	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
REGS1_k127_6539329_1	289376.THEYE_A0436	7.737e-134	432.0	COG0040@1|root,COG0040@2|Bacteria,3J0T5@40117|Nitrospirae	40117|Nitrospirae	F	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity	hisG	GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG,HisG_C
REGS1_k127_6565535_0	338969.Rfer_2741	2.697e-45	169.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria	28216|Betaproteobacteria	T	response regulator	-	-	-	ko:K02481	-	-	-	-	ko00000,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
REGS1_k127_6565535_2	1123373.ATXI01000004_gene1419	8.204e-25	113.0	COG2204@1|root,COG2204@2|Bacteria,2GHIR@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	T	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
REGS1_k127_6565535_3	1191523.MROS_1567	1.197e-22	109.0	COG0509@1|root,COG2204@1|root,COG0509@2|Bacteria,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GAF_2,GCV_H,Response_reg
REGS1_k127_6565535_1	632335.Calkr_1280	5.614e-29	128.0	COG1905@1|root,COG1905@2|Bacteria,1V737@1239|Firmicutes,24HJT@186801|Clostridia,42JBQ@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit	-	-	1.12.1.3	ko:K18330	-	-	-	-	ko00000,ko01000	-	-	-	2Fe-2S_thioredx
REGS1_k127_6573552_3	398578.Daci_1302	1.765e-08	61.0	COG4970@1|root,COG4970@2|Bacteria,1NBWI@1224|Proteobacteria,2VTQ2@28216|Betaproteobacteria,4AEEW@80864|Comamonadaceae	28216|Betaproteobacteria	U	TIGRFAM general secretion pathway protein H	-	-	-	ko:K02457	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	GspH,N_methyl
REGS1_k127_6573552_1	933262.AXAM01000042_gene1810	2.332e-115	384.0	COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,42MH9@68525|delta/epsilon subdivisions,2WJE0@28221|Deltaproteobacteria,2MIYV@213118|Desulfobacterales	28221|Deltaproteobacteria	NU	Type II secretion system (T2SS), protein F	-	-	-	ko:K02455	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSF
REGS1_k127_6573552_0	1304885.AUEY01000014_gene3351	4.291e-177	568.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2WIPP@28221|Deltaproteobacteria,2MHPE@213118|Desulfobacterales	28221|Deltaproteobacteria	NU	type II secretion system protein E	-	-	-	ko:K02454	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSE,T2SSE_N
REGS1_k127_6573552_2	380749.HY04AAS1_1578	2.568e-100	335.0	COG1216@1|root,COG1216@2|Bacteria	2|Bacteria	V	Glycosyl transferase, family 2	rfbN	-	-	ko:K12992	ko02025,map02025	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01005	-	GT2	-	Glyco_tranf_2_3,Glycos_transf_2
REGS1_k127_6577372_3	1121422.AUMW01000013_gene1506	4.832e-12	71.0	COG0640@1|root,COG0640@2|Bacteria,1VEER@1239|Firmicutes,24QZK@186801|Clostridia	186801|Clostridia	K	regulatory protein, arsR	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
REGS1_k127_6577372_1	909663.KI867150_gene1143	7.636e-132	436.0	COG1538@1|root,COG1538@2|Bacteria,1PFBI@1224|Proteobacteria,43A4C@68525|delta/epsilon subdivisions,2X9UW@28221|Deltaproteobacteria,2MS4H@213462|Syntrophobacterales	28221|Deltaproteobacteria	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
REGS1_k127_6577372_2	909663.KI867150_gene1144	2.3e-115	382.0	COG0845@1|root,COG0845@2|Bacteria,1MXGH@1224|Proteobacteria,42STT@68525|delta/epsilon subdivisions,2WPJI@28221|Deltaproteobacteria,2MQHI@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
REGS1_k127_6577372_0	909663.KI867150_gene1145	0.0	1303.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MQ0@68525|delta/epsilon subdivisions,2WISW@28221|Deltaproteobacteria,2MQA5@213462|Syntrophobacterales	28221|Deltaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
REGS1_k127_6588337_0	909663.KI867150_gene2220	2.688e-136	441.0	COG2211@1|root,COG2211@2|Bacteria,1QTSE@1224|Proteobacteria,43C8U@68525|delta/epsilon subdivisions,2X7J6@28221|Deltaproteobacteria,2MSKV@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	Acetyl-coenzyme A transporter 1	-	-	-	ko:K08218	ko01501,map01501	M00628	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.25	-	-	MFS_1
REGS1_k127_6588337_2	876269.ARWA01000001_gene266	4.788e-56	227.0	COG2199@1|root,COG4191@1|root,COG3706@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TYH2@28211|Alphaproteobacteria,3NCC3@45404|Beijerinckiaceae	28211|Alphaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
REGS1_k127_6588337_1	247490.KSU1_C0282	6.651e-118	430.0	COG3829@1|root,COG4191@1|root,COG3829@2|Bacteria,COG4191@2|Bacteria,2J2QC@203682|Planctomycetes	203682|Planctomycetes	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_3,PAS_4
REGS1_k127_6588337_3	247490.KSU1_C1576	3.672e-36	139.0	COG2204@1|root,COG3829@1|root,COG2204@2|Bacteria,COG3829@2|Bacteria,2J2D8@203682|Planctomycetes	203682|Planctomycetes	KT	Sigma-54 interaction domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,PAS_10,PAS_4,Response_reg,Sigma54_activat
REGS1_k127_6635214_0	1410653.JHVC01000005_gene2573	1.203e-13	83.0	COG3307@1|root,COG3307@2|Bacteria,1TQGY@1239|Firmicutes,24AB7@186801|Clostridia,36ERI@31979|Clostridiaceae	186801|Clostridia	M	O-Antigen ligase	-	-	-	ko:K18814	-	-	-	-	ko00000,ko02000	9.B.67.1	-	-	Wzy_C
REGS1_k127_6635347_3	56780.SYN_02092	3.125e-57	213.0	COG2199@1|root,COG3850@1|root,COG2199@2|Bacteria,COG3850@2|Bacteria,1PDZX@1224|Proteobacteria,439X0@68525|delta/epsilon subdivisions,2X9W0@28221|Deltaproteobacteria,2MRYK@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	Diguanylate cyclase, GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
REGS1_k127_6635347_0	671143.DAMO_2945	6.397e-312	974.0	COG0188@1|root,COG0188@2|Bacteria,2NNNR@2323|unclassified Bacteria	2|Bacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
REGS1_k127_6635347_5	289376.THEYE_A0584	3.012e-40	156.0	COG0357@1|root,COG0357@2|Bacteria,3J18F@40117|Nitrospirae	40117|Nitrospirae	J	Specifically methylates the N7 position of a guanine in 16S rRNA	gidB	-	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB
REGS1_k127_6635347_2	1123371.ATXH01000005_gene2042	1.649e-75	258.0	COG2231@1|root,COG2231@2|Bacteria,2GH00@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	L	endonuclease III	-	-	-	ko:K07457	-	-	-	-	ko00000	-	-	-	HhH-GPD
REGS1_k127_6635347_4	1047013.AQSP01000122_gene2257	1.729e-40	153.0	COG1186@1|root,COG1186@2|Bacteria	2|Bacteria	J	translation release factor activity	prfA3	-	-	-	-	-	-	-	-	-	-	-	RF-1
REGS1_k127_6635347_6	903814.ELI_2355	1.176e-09	61.0	COG0024@1|root,COG0024@2|Bacteria,1TQC1@1239|Firmicutes,248I8@186801|Clostridia,25VYS@186806|Eubacteriaceae	186801|Clostridia	J	Metallopeptidase family M24	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24,SEC-C
REGS1_k127_6635347_1	1123376.AUIU01000012_gene1453	3.967e-231	725.0	COG0445@1|root,COG0445@2|Bacteria,3J0E9@40117|Nitrospirae	40117|Nitrospirae	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
REGS1_k127_6662310_0	909663.KI867150_gene1564	9.335e-220	691.0	COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,42NJD@68525|delta/epsilon subdivisions,2WJFK@28221|Deltaproteobacteria,2MQ92@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	Belongs to the peptidase S16 family	-	-	3.4.21.53	ko:K01338,ko:K04076	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA_32,Lon_C,Mg_chelatase
REGS1_k127_6721172_3	1263831.F543_20540	2.053e-09	58.0	COG2852@1|root,COG2852@2|Bacteria,1N0QU@1224|Proteobacteria,1SAT7@1236|Gammaproteobacteria,1Y8ME@135625|Pasteurellales	135625|Pasteurellales	S	Protein of unknown function (DUF559)	-	-	-	-	-	-	-	-	-	-	-	-	DUF559
REGS1_k127_6721172_2	289376.THEYE_A0224	1.567e-33	134.0	COG1051@1|root,COG1051@2|Bacteria,3J1FA@40117|Nitrospirae	40117|Nitrospirae	F	Belongs to the Nudix hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
REGS1_k127_6721172_1	289376.THEYE_A0223	9.793e-57	203.0	COG0615@1|root,COG1778@1|root,COG0615@2|Bacteria,COG1778@2|Bacteria,3J0JP@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose	-	-	-	-	-	-	-	-	-	-	-	-	CTP_transf_like,Hydrolase_3
REGS1_k127_6721172_0	1329516.JPST01000015_gene805	7.692e-225	731.0	COG1197@1|root,COG1197@2|Bacteria,1TPF1@1239|Firmicutes,4H9NB@91061|Bacilli,27AZA@186824|Thermoactinomycetaceae	91061|Bacilli	L	TRCF	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
REGS1_k127_6721931_0	289376.THEYE_A1233	2.911e-175	557.0	COG1190@1|root,COG1190@2|Bacteria,3J0AW@40117|Nitrospirae	40117|Nitrospirae	J	tRNA synthetases class II (D, K and N)	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
REGS1_k127_6721931_1	637389.Acaty_c1088	1.438e-37	144.0	COG0282@1|root,COG0282@2|Bacteria,1MW61@1224|Proteobacteria,1RMKB@1236|Gammaproteobacteria,2NBRA@225057|Acidithiobacillales	225057|Acidithiobacillales	H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	-	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetate_kinase
REGS1_k127_6736766_9	717231.Flexsi_0107	7.211e-05	49.0	COG0745@1|root,COG0745@2|Bacteria,2GFSV@200930|Deferribacteres	200930|Deferribacteres	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
REGS1_k127_6736766_0	316067.Geob_3082	0.0	1075.0	COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,42MPZ@68525|delta/epsilon subdivisions,2WIR9@28221|Deltaproteobacteria,43TAT@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
REGS1_k127_6736766_2	289376.THEYE_A0886	3.548e-87	296.0	COG0157@1|root,COG0157@2|Bacteria,3J0JY@40117|Nitrospirae	40117|Nitrospirae	H	Quinolinate phosphoribosyl transferase, C-terminal domain	nadC	-	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	-	QRPTase_C,QRPTase_N
REGS1_k127_6736766_7	1123376.AUIU01000012_gene1352	7.647e-26	109.0	COG1254@1|root,COG1254@2|Bacteria	2|Bacteria	C	Belongs to the acylphosphatase family	acyP	GO:0003674,GO:0003824,GO:0003998,GO:0016787,GO:0016817,GO:0016818	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	-	R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000	-	-	-	Acylphosphatase
REGS1_k127_6736766_8	796606.BMMGA3_12605	6.371e-22	104.0	COG2804@1|root,COG2804@2|Bacteria,1TPGE@1239|Firmicutes,4HB0C@91061|Bacilli,1ZD5J@1386|Bacillus	91061|Bacilli	NU	COG2804 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB	pilB	-	-	ko:K02243,ko:K02652	-	M00429	-	-	ko00000,ko00002,ko02035,ko02044	3.A.14.1,3.A.15.2	-	-	T2SSE,T2SSE_N
REGS1_k127_6736766_1	1123376.AUIU01000013_gene1740	1.44e-94	320.0	COG0502@1|root,COG0502@2|Bacteria,3J0I9@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism	bioB	-	2.8.1.6	ko:K01012	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000	-	-	-	BATS,Radical_SAM
REGS1_k127_6736766_5	289376.THEYE_A0810	2.141e-51	193.0	COG1424@1|root,COG1424@2|Bacteria,3J1AG@40117|Nitrospirae	40117|Nitrospirae	H	6-carboxyhexanoate--CoA ligase	-	-	6.2.1.14	ko:K01906	ko00780,ko01100,map00780,map01100	M00577	R03209	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	BioW
REGS1_k127_6736766_4	289376.THEYE_A0811	2.016e-66	236.0	COG1597@1|root,COG1597@2|Bacteria,3J1CE@40117|Nitrospirae	40117|Nitrospirae	I	Diacylglycerol kinase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
REGS1_k127_6736766_3	1485545.JQLW01000010_gene1621	1.337e-67	241.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,GAF_2,HAMP,HATPase_c,HisKA,PAS,PAS_3,PAS_9,Response_reg,dCache_1
REGS1_k127_6737350_1	1123376.AUIU01000002_gene1673	1.696e-63	222.0	COG0691@1|root,COG0691@2|Bacteria,3J0Q4@40117|Nitrospirae	40117|Nitrospirae	O	the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA	smpB	-	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
REGS1_k127_6737350_0	1123376.AUIU01000016_gene199	2.598e-101	343.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
REGS1_k127_6759569_2	1123376.AUIU01000011_gene844	1.283e-36	151.0	COG0641@1|root,COG0641@2|Bacteria	2|Bacteria	C	radical SAM	-	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
REGS1_k127_6759569_1	909663.KI867150_gene1861	1.271e-75	258.0	COG0655@1|root,COG0655@2|Bacteria,1NANP@1224|Proteobacteria,42Q16@68525|delta/epsilon subdivisions,2WIJ7@28221|Deltaproteobacteria,2MQJ5@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	PFAM NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red,LMWPc
REGS1_k127_6759569_0	269799.Gmet_2726	3.133e-128	415.0	COG2321@1|root,COG2321@2|Bacteria,1MU4U@1224|Proteobacteria,42N0U@68525|delta/epsilon subdivisions,2WJH3@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Putative neutral zinc metallopeptidase	-	-	-	ko:K07054	-	-	-	-	ko00000	-	-	-	Zn_peptidase
REGS1_k127_6787805_1	309799.DICTH_1783	9.986e-84	286.0	COG3259@1|root,COG3259@2|Bacteria	2|Bacteria	C	Nickel-dependent hydrogenase	-	-	1.12.1.2	ko:K00436	-	-	R00700	-	ko00000,ko01000	-	-	-	NiFeSe_Hases
REGS1_k127_6787805_0	56110.Oscil6304_3385	7.264e-202	654.0	COG0515@1|root,COG2199@1|root,COG3899@1|root,COG5002@1|root,COG0515@2|Bacteria,COG3706@2|Bacteria,COG3899@2|Bacteria,COG5002@2|Bacteria,1GBKM@1117|Cyanobacteria,1H7D9@1150|Oscillatoriales	2|Bacteria	KLT	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GAF,GAF_2,GGDEF,Guanylate_cyc,HATPase_c,HisKA,PAS_9,Pkinase,Response_reg
REGS1_k127_6787805_2	1089553.Tph_c22670	1.424e-19	94.0	COG0680@1|root,COG0680@2|Bacteria,1V7KQ@1239|Firmicutes,24IHW@186801|Clostridia,42HCG@68295|Thermoanaerobacterales	186801|Clostridia	C	hydrogenase maturation protease	-	-	-	ko:K03605	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	HycI
REGS1_k127_6808339_3	1304885.AUEY01000052_gene1549	7.612e-24	105.0	2CCD9@1|root,2ZWK6@2|Bacteria	2|Bacteria	S	YtkA-like	-	-	-	-	-	-	-	-	-	-	-	-	YtkA
REGS1_k127_6808339_1	1304885.AUEY01000052_gene1548	1.032e-121	405.0	COG1538@1|root,COG1538@2|Bacteria,1PCPQ@1224|Proteobacteria,42PZ3@68525|delta/epsilon subdivisions,2WJU4@28221|Deltaproteobacteria,2MIHB@213118|Desulfobacterales	28221|Deltaproteobacteria	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
REGS1_k127_6808339_0	1304885.AUEY01000052_gene1547	3.303e-122	406.0	COG0845@1|root,COG0845@2|Bacteria,1MVAS@1224|Proteobacteria,42PKU@68525|delta/epsilon subdivisions,2WM5K@28221|Deltaproteobacteria,2MIM9@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K07798,ko:K15727	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4,8.A.1,8.A.1.2.1	-	-	DUF3347,HlyD_D23
REGS1_k127_6808339_2	1304885.AUEY01000031_gene51	8.023e-71	241.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,42NCZ@68525|delta/epsilon subdivisions,2WK3X@28221|Deltaproteobacteria,2MI5E@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K07787	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4	-	iAF987.Gmet_1547	ACR_tran
REGS1_k127_6814314_1	443143.GM18_0321	8.557e-43	175.0	2DTK4@1|root,33KQK@2|Bacteria,1NIAG@1224|Proteobacteria,42XD2@68525|delta/epsilon subdivisions,2WTAV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_6814314_0	859657.RPSI07_3268	1.181e-71	275.0	COG4625@1|root,COG4625@2|Bacteria,1QU2X@1224|Proteobacteria,2VHDJ@28216|Betaproteobacteria,1KAIY@119060|Burkholderiaceae	28216|Betaproteobacteria	S	TIGRFAM outer membrane autotransporter barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Autotransporter,He_PIG,TIG
REGS1_k127_6817367_0	1173025.GEI7407_1092	1.195e-60	227.0	COG1472@1|root,COG1472@2|Bacteria,1G29F@1117|Cyanobacteria,1H8WD@1150|Oscillatoriales	1117|Cyanobacteria	G	PFAM Glycosyl hydrolase family 3 N terminal domain	bgl	-	3.2.1.21,3.2.1.52	ko:K01207,ko:K05349	ko00460,ko00500,ko00520,ko00531,ko00940,ko01100,ko01110,ko01501,map00460,map00500,map00520,map00531,map00940,map01100,map01110,map01501	M00628	R00022,R00026,R02558,R02887,R02985,R03527,R04949,R04998,R05963,R07809,R07810,R10035,R10039,R10040,R10831	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko00002,ko01000	-	GH3	-	Glyco_hydro_3
REGS1_k127_6817367_5	1123376.AUIU01000018_gene60	6.632e-07	58.0	2C9ST@1|root,2ZVIC@2|Bacteria	1123376.AUIU01000018_gene60|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_6817367_4	1379698.RBG1_1C00001G0531	2.994e-30	132.0	COG0451@1|root,COG0451@2|Bacteria,2NPC7@2323|unclassified Bacteria	2|Bacteria	GM	NAD(P)H-binding	JD73_00815	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
REGS1_k127_6817367_1	335543.Sfum_0440	4.505e-59	209.0	COG0778@1|root,COG0778@2|Bacteria,1PDTZ@1224|Proteobacteria,42SQ3@68525|delta/epsilon subdivisions,2WPC5@28221|Deltaproteobacteria,2MQPP@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
REGS1_k127_6817367_2	1121035.AUCH01000005_gene125	3.305e-44	178.0	COG2199@1|root,COG3706@2|Bacteria,1MYK0@1224|Proteobacteria	1224|Proteobacteria	T	COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Response_reg
REGS1_k127_6817367_3	504472.Slin_6011	6.091e-38	146.0	COG1309@1|root,COG1309@2|Bacteria,4NKU9@976|Bacteroidetes,47MM9@768503|Cytophagia	976|Bacteroidetes	K	WHG domain	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N,WHG
REGS1_k127_684664_1	868595.Desca_1454	2.109e-161	525.0	COG0513@1|root,COG0513@2|Bacteria,1TPAP@1239|Firmicutes,247IT@186801|Clostridia,2600W@186807|Peptococcaceae	186801|Clostridia	L	Belongs to the DEAD box helicase family	cshA	-	3.6.4.13	ko:K05592	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,DbpA,Helicase_C
REGS1_k127_684664_2	929703.KE386491_gene2674	3.269e-31	129.0	COG1430@1|root,COG1430@2|Bacteria,4NQ5G@976|Bacteroidetes,47R49@768503|Cytophagia	976|Bacteroidetes	S	Uncharacterized ACR, COG1430	-	-	-	ko:K09005	-	-	-	-	ko00000	-	-	-	DUF192
REGS1_k127_684664_0	338966.Ppro_2348	4.922e-287	904.0	COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,42MD4@68525|delta/epsilon subdivisions,2WJ7Z@28221|Deltaproteobacteria,43S5U@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	TIGRFAM ATP-dependent helicase HrpB	hrpB	-	3.6.4.13	ko:K03579	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HA2,Helicase_C,HrpB_C
REGS1_k127_684664_3	1453503.AU05_10110	7.269e-28	115.0	COG0727@1|root,32S46@2|Bacteria,1MZCU@1224|Proteobacteria,1SCG7@1236|Gammaproteobacteria,1YGY5@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	Putative zinc- or iron-chelating domain	yeiW	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
REGS1_k127_6937640_0	215803.DB30_6870	7.418e-172	560.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,42MKU@68525|delta/epsilon subdivisions,2WJR3@28221|Deltaproteobacteria,2YWBK@29|Myxococcales	28221|Deltaproteobacteria	L	UvrD-like helicase C-terminal domain	-	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
REGS1_k127_6937640_2	1123376.AUIU01000015_gene349	7.989e-34	133.0	COG1862@1|root,COG1862@2|Bacteria,3J0UB@40117|Nitrospirae	40117|Nitrospirae	U	Preprotein translocase subunit	yajC	-	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
REGS1_k127_6937640_1	289376.THEYE_A0280	5.65e-104	349.0	COG0342@1|root,COG0342@2|Bacteria,3J09Z@40117|Nitrospirae	40117|Nitrospirae	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
REGS1_k127_6972996_2	398767.Glov_1901	3.674e-175	556.0	COG0519@1|root,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,42M0I@68525|delta/epsilon subdivisions,2WJ6D@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Catalyzes the synthesis of GMP from XMP	guaA	GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase,tRNA_Me_trans
REGS1_k127_6972996_0	289376.THEYE_A0206	4.226e-228	724.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,3J0A1@40117|Nitrospirae	40117|Nitrospirae	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
REGS1_k127_6972996_4	589865.DaAHT2_0247	8.498e-22	99.0	28XS9@1|root,2ZJNQ@2|Bacteria	2|Bacteria	P	Cytochrome c7 and related cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C7
REGS1_k127_6972996_3	289376.THEYE_A1153	6.442e-150	478.0	COG0115@1|root,COG0115@2|Bacteria,3J0BM@40117|Nitrospirae	40117|Nitrospirae	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
REGS1_k127_6972996_1	1380391.JIAS01000011_gene5214	2.336e-207	661.0	COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,2TS3Y@28211|Alphaproteobacteria,2JQHX@204441|Rhodospirillales	204441|Rhodospirillales	J	Arginyl-tRNA synthetase	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
REGS1_k127_6972996_5	1479239.JQMU01000001_gene1698	3.048e-09	65.0	COG2197@1|root,COG2197@2|Bacteria,1RGXD@1224|Proteobacteria,2VEYZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
REGS1_k127_6973818_2	243090.RB8978	1.024e-72	253.0	COG1235@1|root,COG1235@2|Bacteria,2IZQK@203682|Planctomycetes	203682|Planctomycetes	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
REGS1_k127_6973818_5	706587.Desti_1382	6.603e-36	142.0	COG2391@1|root,COG2391@2|Bacteria,1N3PQ@1224|Proteobacteria,42URY@68525|delta/epsilon subdivisions,2WQYF@28221|Deltaproteobacteria,2MRYS@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Sulphur transport	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
REGS1_k127_6973818_4	706587.Desti_1381	1.55e-41	161.0	COG2391@1|root,COG2391@2|Bacteria,1RIWE@1224|Proteobacteria,42QRV@68525|delta/epsilon subdivisions,2WMUE@28221|Deltaproteobacteria,2MS98@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	Sulphur transport	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
REGS1_k127_6973818_6	1205680.CAKO01000035_gene218	5.808e-13	79.0	COG1295@1|root,COG1295@2|Bacteria,1R9UY@1224|Proteobacteria,2U3WV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	TIGRFAM YihY family protein (not ribonuclease BN)	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
REGS1_k127_6973818_0	1243664.CAVL020000008_gene4089	1.298e-121	404.0	COG1160@1|root,COG1160@2|Bacteria,1TPNM@1239|Firmicutes,4HAJ6@91061|Bacilli,1ZAUP@1386|Bacillus	91061|Bacilli	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
REGS1_k127_6973818_1	316067.Geob_3454	3.269e-103	360.0	COG2203@1|root,COG2206@1|root,COG3850@1|root,COG2203@2|Bacteria,COG2206@2|Bacteria,COG3850@2|Bacteria,1RAQS@1224|Proteobacteria,42MEJ@68525|delta/epsilon subdivisions,2WP5V@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	metal-dependent phosphohydrolase, HD sub domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HAMP,HD_5
REGS1_k127_6973818_3	748280.NH8B_1791	3.406e-46	174.0	COG1226@1|root,COG1226@2|Bacteria,1MU1R@1224|Proteobacteria,2WEJI@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Ion transport 2 domain protein	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans_2,TrkA_N
REGS1_k127_6996595_2	289376.THEYE_A0166	3.738e-155	499.0	COG0265@1|root,COG0265@2|Bacteria,3J0VW@40117|Nitrospirae	40117|Nitrospirae	O	Trypsin	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
REGS1_k127_6996595_5	525897.Dbac_1921	2.926e-65	228.0	COG3448@1|root,COG3448@2|Bacteria,1MXJG@1224|Proteobacteria,42RSQ@68525|delta/epsilon subdivisions,2WNED@28221|Deltaproteobacteria,2MBBZ@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	HPP family	-	-	-	ko:K07168	-	-	-	-	ko00000	-	-	-	HPP
REGS1_k127_6996595_7	439235.Dalk_3566	1.267e-32	135.0	COG3448@1|root,COG3448@2|Bacteria,1Q1A8@1224|Proteobacteria,42SIQ@68525|delta/epsilon subdivisions,2WPF0@28221|Deltaproteobacteria,2MKBJ@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
REGS1_k127_6996595_6	404589.Anae109_1413	6.287e-41	160.0	COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,42UBZ@68525|delta/epsilon subdivisions,2WQ0E@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	Belongs to the SUA5 family	-	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	Sua5_yciO_yrdC
REGS1_k127_6996595_0	56780.SYN_00538	3.852e-187	597.0	COG1032@1|root,COG1032@2|Bacteria,1PDZR@1224|Proteobacteria,42M73@68525|delta/epsilon subdivisions,2WK6Y@28221|Deltaproteobacteria,2MQ41@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
REGS1_k127_6996595_1	1445613.JALM01000009_gene829	8.825e-172	557.0	COG3119@1|root,COG3119@2|Bacteria,2GJ8H@201174|Actinobacteria,4DZR1@85010|Pseudonocardiales	201174|Actinobacteria	P	Sulfatase	-	-	3.1.6.14	ko:K01137	ko00531,ko01100,ko04142,map00531,map01100,map04142	M00078,M00079	R07808,R07819	-	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4976,Sulfatase
REGS1_k127_6996595_8	485916.Dtox_0166	2.301e-13	72.0	COG1826@1|root,COG1826@2|Bacteria,1TV3X@1239|Firmicutes,259BA@186801|Clostridia,2639X@186807|Peptococcaceae	186801|Clostridia	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	tatA	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
REGS1_k127_6996595_4	583345.Mmol_0126	9.915e-70	250.0	COG4251@1|root,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria,2W8ZW@28216|Betaproteobacteria,2KNV7@206350|Nitrosomonadales	206350|Nitrosomonadales	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_9,Protoglobin
REGS1_k127_6996595_3	316067.Geob_1840	1.118e-77	266.0	COG1801@1|root,COG1801@2|Bacteria,1MU7F@1224|Proteobacteria,43BI9@68525|delta/epsilon subdivisions,2X6WN@28221|Deltaproteobacteria,43U6T@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
REGS1_k127_7009297_1	316067.Geob_0970	8.225e-27	117.0	COG3064@1|root,COG3064@2|Bacteria,1NKQI@1224|Proteobacteria,43B4Y@68525|delta/epsilon subdivisions,2WSRY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_7009297_0	552811.Dehly_0886	6.569e-142	464.0	COG1249@1|root,COG1249@2|Bacteria,2G5MR@200795|Chloroflexi,34DQQ@301297|Dehalococcoidia	200795|Chloroflexi	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	lpd	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
REGS1_k127_7026231_4	1123376.AUIU01000011_gene922	1.41e-161	522.0	COG0265@1|root,COG0265@2|Bacteria,3J0X9@40117|Nitrospirae	40117|Nitrospirae	M	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
REGS1_k127_7026231_2	1123376.AUIU01000014_gene605	3.936e-172	547.0	COG0075@1|root,COG0075@2|Bacteria,3J0FC@40117|Nitrospirae	40117|Nitrospirae	E	Evidence 2b Function of strongly homologous gene	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
REGS1_k127_7026231_1	1123376.AUIU01000014_gene606	2.791e-234	736.0	COG0111@1|root,COG0111@2|Bacteria,3J0DZ@40117|Nitrospirae	40117|Nitrospirae	E	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	serA	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
REGS1_k127_7026231_3	1162668.LFE_2059	9.524e-164	525.0	COG0104@1|root,COG0104@2|Bacteria,3J0FV@40117|Nitrospirae	40117|Nitrospirae	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
REGS1_k127_7026231_6	1232410.KI421412_gene403	3.335e-41	161.0	COG1040@1|root,COG1040@2|Bacteria,1RHAV@1224|Proteobacteria,42TFK@68525|delta/epsilon subdivisions,2WPQG@28221|Deltaproteobacteria,43UBR@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	competence protein	-	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
REGS1_k127_7026231_0	1125863.JAFN01000001_gene1819	0.0	1065.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,42MHP@68525|delta/epsilon subdivisions,2WJY2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.17	ko:K01908	ko00640,ko01100,map00640,map01100	-	R00926,R01354	RC00004,RC00043,RC00070,RC02816	ko00000,ko00001,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
REGS1_k127_7026231_7	373903.Hore_06720	1.352e-09	61.0	COG3290@1|root,COG3829@1|root,COG3290@2|Bacteria,COG3829@2|Bacteria,1TP0E@1239|Firmicutes,247MB@186801|Clostridia,3WBBB@53433|Halanaerobiales	186801|Clostridia	KT	Sigma54 specific transcriptional regulator, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,PAS,PAS_9,Sigma54_activat
REGS1_k127_7026231_5	289376.THEYE_A0609	1.269e-81	278.0	COG1387@1|root,COG1387@2|Bacteria	2|Bacteria	E	zinc ion binding	-	-	-	-	-	-	-	-	-	-	-	-	PHP
REGS1_k127_7042987_1	56780.SYN_02012	1.537e-116	382.0	COG0389@1|root,COG0389@2|Bacteria,1MUUH@1224|Proteobacteria,42NGG@68525|delta/epsilon subdivisions,2WIVT@28221|Deltaproteobacteria,2MQEQ@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
REGS1_k127_7042987_3	1231241.Mc24_07834	1.067e-48	178.0	COG1490@1|root,COG1490@2|Bacteria,2GCYQ@200918|Thermotogae	200918|Thermotogae	J	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality	dtd	GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360	-	ko:K07560	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Tyr_Deacylase
REGS1_k127_7042987_2	1123376.AUIU01000002_gene1664	2.734e-104	346.0	COG1210@1|root,COG1210@2|Bacteria,3J0B2@40117|Nitrospirae	40117|Nitrospirae	M	Nucleotidyl transferase	galU	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
REGS1_k127_7042987_0	1123376.AUIU01000002_gene1663	5.373e-188	595.0	COG0466@1|root,COG0466@2|Bacteria,3J0DQ@40117|Nitrospirae	40117|Nitrospirae	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
REGS1_k127_7083580_5	1156937.MFUM_270049	1.016e-18	86.0	28N8G@1|root,2ZBCV@2|Bacteria,46YX3@74201|Verrucomicrobia,37GD5@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_7083580_2	243231.GSU1160	1.303e-35	140.0	COG3794@1|root,COG3794@2|Bacteria,1N0BX@1224|Proteobacteria	1224|Proteobacteria	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1
REGS1_k127_7083580_1	1232410.KI421413_gene779	1.498e-39	153.0	COG3794@1|root,COG3794@2|Bacteria,1N3IJ@1224|Proteobacteria,42TYB@68525|delta/epsilon subdivisions,2WR42@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Cytochrome P460	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_P460
REGS1_k127_7083580_4	1307759.JOMJ01000004_gene2996	5.126e-26	110.0	COG1225@1|root,COG1225@2|Bacteria,1N16N@1224|Proteobacteria	1224|Proteobacteria	O	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
REGS1_k127_7083580_6	1121381.JNIV01000031_gene2418	0.0003617	44.0	COG1225@1|root,COG1225@2|Bacteria	2|Bacteria	O	peroxiredoxin activity	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
REGS1_k127_7083580_0	1123376.AUIU01000007_gene1193	2.617e-84	284.0	COG0177@1|root,COG0177@2|Bacteria,3J0K6@40117|Nitrospirae	40117|Nitrospirae	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
REGS1_k127_7083580_3	335543.Sfum_3094	4.649e-30	122.0	28HPC@1|root,2Z7XD@2|Bacteria,1PQBF@1224|Proteobacteria,42WX9@68525|delta/epsilon subdivisions,2WT62@28221|Deltaproteobacteria,2MSEC@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4337)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4337
REGS1_k127_708463_1	289376.THEYE_A1047	3.654e-97	324.0	COG0442@1|root,COG0442@2|Bacteria,3J0EY@40117|Nitrospirae	40117|Nitrospirae	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
REGS1_k127_708463_0	32057.KB217478_gene2230	6.342e-305	966.0	COG1352@1|root,COG2201@1|root,COG5002@1|root,COG1352@2|Bacteria,COG2201@2|Bacteria,COG5002@2|Bacteria,1GHEK@1117|Cyanobacteria	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	2.1.1.80,3.1.1.61	ko:K13924	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,CheR,CheR_N,HATPase_c,HisKA,PAS_10,PAS_4
REGS1_k127_7085057_1	289376.THEYE_A0726	2.123e-86	299.0	COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria	2|Bacteria	GT	kinase activity	ppdK	-	2.7.9.1,2.7.9.2	ko:K01006,ko:K01007	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173,M00374	R00199,R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
REGS1_k127_7085057_2	289377.HL41_08255	6.113e-45	168.0	COG0517@1|root,COG0517@2|Bacteria,2GIDB@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	IMP dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_7085057_0	1123392.AQWL01000006_gene639	1.576e-164	523.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,1KSIU@119069|Hydrogenophilales	119069|Hydrogenophilales	T	Sigma-54 interaction domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
REGS1_k127_71027_3	909663.KI867150_gene1931	7.493e-71	244.0	COG2064@1|root,COG2064@2|Bacteria,1MWAZ@1224|Proteobacteria,42R2X@68525|delta/epsilon subdivisions,2WMU1@28221|Deltaproteobacteria,2MQBQ@213462|Syntrophobacterales	28221|Deltaproteobacteria	NU	PFAM type II secretion system	-	-	-	ko:K12511	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
REGS1_k127_71027_8	521098.Aaci_1182	6.469e-14	80.0	COG2020@1|root,COG2020@2|Bacteria	2|Bacteria	O	methyltransferase activity	ste14	-	-	-	-	-	-	-	-	-	-	-	ICMT,PEMT
REGS1_k127_71027_5	1347369.CCAD010000055_gene4191	2.329e-20	103.0	COG1466@1|root,COG1466@2|Bacteria,1TRM0@1239|Firmicutes,4HBB4@91061|Bacilli,1ZBST@1386|Bacillus	91061|Bacilli	L	DNA polymerase III delta subunit	holA	-	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta
REGS1_k127_71027_0	289376.THEYE_A1204	0.0	1109.0	COG0495@1|root,COG0495@2|Bacteria,3J0F8@40117|Nitrospirae	40117|Nitrospirae	J	Leucyl-tRNA synthetase, Domain 2	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1
REGS1_k127_71027_6	102129.Lepto7375DRAFT_1712	6.873e-18	93.0	COG0745@1|root,COG4251@1|root,COG0745@2|Bacteria,COG4251@2|Bacteria,1GHFQ@1117|Cyanobacteria,1HHWS@1150|Oscillatoriales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,PAS_9,Response_reg
REGS1_k127_71027_2	671143.DAMO_0410	6.173e-259	812.0	COG2060@1|root,COG2060@2|Bacteria,2NP13@2323|unclassified Bacteria	2|Bacteria	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane	kdpA	GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0030312,GO:0030955,GO:0031004,GO:0031224,GO:0031226,GO:0031420,GO:0032991,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043167,GO:0043169,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0090533,GO:0090662,GO:0098533,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1902494,GO:1902495,GO:1904949,GO:1990351	3.6.3.12	ko:K01546	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	iAPECO1_1312.APECO1_1369,iECUMN_1333.ECUMN_0780,iYL1228.KPN_00717	KdpA
REGS1_k127_71027_1	448385.sce1353	0.0	1013.0	COG2216@1|root,COG2216@2|Bacteria,1MU7D@1224|Proteobacteria,42NGX@68525|delta/epsilon subdivisions,2WJC0@28221|Deltaproteobacteria,2YWXY@29|Myxococcales	28221|Deltaproteobacteria	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system	kdpB	-	3.6.3.12	ko:K01547	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	iAF987.Gmet_2434	E1-E2_ATPase,Hydrolase
REGS1_k127_71027_4	243233.MCA2215	1.603e-69	240.0	COG2156@1|root,COG2156@2|Bacteria,1RABG@1224|Proteobacteria,1S2B0@1236|Gammaproteobacteria,1XF8W@135618|Methylococcales	135618|Methylococcales	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex	kdpC	-	3.6.3.12	ko:K01548	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	-	KdpC
REGS1_k127_71027_10	269799.Gmet_1561	1.482e-09	66.0	2CCGA@1|root,343UD@2|Bacteria,1P3JZ@1224|Proteobacteria,43123@68525|delta/epsilon subdivisions,2WWQS@28221|Deltaproteobacteria,43VIT@69541|Desulfuromonadales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_710382_1	1232410.KI421422_gene1992	4.689e-59	213.0	COG4191@1|root,COG4191@2|Bacteria,1R6WR@1224|Proteobacteria,42PFK@68525|delta/epsilon subdivisions,2WJSP@28221|Deltaproteobacteria,43TXV@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_4,PAS_9
REGS1_k127_710382_0	880073.Calab_2887	3.43e-135	443.0	COG2204@1|root,COG2204@2|Bacteria,2NQHI@2323|unclassified Bacteria	2|Bacteria	T	Sigma-54 interaction domain	-	-	-	ko:K02481,ko:K07714	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
REGS1_k127_710382_2	903818.KI912268_gene1303	1.342e-27	116.0	COG4191@1|root,COG4191@2|Bacteria,3Y2IQ@57723|Acidobacteria	57723|Acidobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg
REGS1_k127_7139040_2	983920.Y88_1081	1.804e-28	121.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2TQWE@28211|Alphaproteobacteria,2K1JW@204457|Sphingomonadales	204457|Sphingomonadales	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
REGS1_k127_7139040_4	349161.Dred_0717	1.653e-16	81.0	COG1872@1|root,COG1872@2|Bacteria,1VFSH@1239|Firmicutes,24T87@186801|Clostridia,262RJ@186807|Peptococcaceae	186801|Clostridia	S	Belongs to the UPF0235 family	-	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
REGS1_k127_7139040_6	243231.GSU3563	1.308e-05	52.0	2BXCM@1|root,34044@2|Bacteria,1NYPR@1224|Proteobacteria,430TJ@68525|delta/epsilon subdivisions,2WVQ3@28221|Deltaproteobacteria,43V6P@69541|Desulfuromonadales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_7139040_5	1121918.ARWE01000001_gene1964	2.655e-09	66.0	2DX7M@1|root,343RD@2|Bacteria,1QC6U@1224|Proteobacteria,4320F@68525|delta/epsilon subdivisions,2WWWP@28221|Deltaproteobacteria,43VHZ@69541|Desulfuromonadales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_7139040_1	1469607.KK073768_gene4603	2.134e-35	142.0	COG1047@1|root,COG1047@2|Bacteria,1G5R4@1117|Cyanobacteria,1HSF7@1161|Nostocales	1117|Cyanobacteria	O	FKBP-type peptidyl-prolyl cis-trans isomerase	-	-	5.2.1.8	ko:K01802	-	-	-	-	ko00000,ko01000	-	-	-	FKBP_C
REGS1_k127_7139040_0	1123376.AUIU01000015_gene372	9.477e-108	360.0	COG0820@1|root,COG0820@2|Bacteria,3J0CH@40117|Nitrospirae	40117|Nitrospirae	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	-	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Fer4_14,Radical_SAM
REGS1_k127_7139040_3	161156.JQKW01000012_gene33	4.711e-19	94.0	COG3063@1|root,COG3063@2|Bacteria,2GHJH@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	NU	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_2,TPR_8
REGS1_k127_7151397_4	706587.Desti_0262	6.069e-37	144.0	COG0500@1|root,COG2226@2|Bacteria,1PEBD@1224|Proteobacteria,42T7H@68525|delta/epsilon subdivisions,2WPN7@28221|Deltaproteobacteria,2MQP2@213462|Syntrophobacterales	28221|Deltaproteobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_31
REGS1_k127_7151397_3	269799.Gmet_1733	6.005e-63	228.0	COG0500@1|root,COG0500@2|Bacteria,1QW86@1224|Proteobacteria,42N1Q@68525|delta/epsilon subdivisions,2WJJS@28221|Deltaproteobacteria,43TSG@69541|Desulfuromonadales	28221|Deltaproteobacteria	Q	Dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	Dimerisation2,Methyltransf_2
REGS1_k127_7151397_5	289376.THEYE_A0043	4.382e-35	142.0	COG0760@1|root,COG0760@2|Bacteria,3J1BR@40117|Nitrospirae	40117|Nitrospirae	O	SurA N-terminal domain	-	-	5.2.1.8	ko:K03770	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	SurA_N_3
REGS1_k127_7151397_6	1137799.GZ78_11955	7.624e-21	93.0	COG1923@1|root,COG1923@2|Bacteria,1MZM1@1224|Proteobacteria,1S8W0@1236|Gammaproteobacteria,1XKET@135619|Oceanospirillales	135619|Oceanospirillales	J	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs	hfq	-	-	ko:K03666	ko02024,ko03018,ko05111,map02024,map03018,map05111	-	-	-	ko00000,ko00001,ko03019,ko03036	-	-	-	Hfq
REGS1_k127_7151397_2	289376.THEYE_A0817	9.598e-101	338.0	COG0324@1|root,COG0324@2|Bacteria,3J0KS@40117|Nitrospirae	40117|Nitrospirae	J	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
REGS1_k127_7151397_0	289376.THEYE_A2083	4.116e-126	423.0	COG0323@1|root,COG0323@2|Bacteria,3J0GN@40117|Nitrospirae	40117|Nitrospirae	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
REGS1_k127_7151397_1	589865.DaAHT2_1512	1.872e-114	372.0	COG0563@1|root,COG0563@2|Bacteria,1MXCZ@1224|Proteobacteria,42M8E@68525|delta/epsilon subdivisions,2WJH0@28221|Deltaproteobacteria,2MIFR@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK,ATP_bind_3
REGS1_k127_7232462_0	1131269.AQVV01000001_gene1469	4.918e-48	180.0	COG0457@1|root,COG1262@1|root,COG0457@2|Bacteria,COG1262@2|Bacteria	2|Bacteria	T	PFAM Formylglycine-generating sulfatase enzyme	-	-	1.14.99.50	ko:K18912	ko00340,map00340	-	R11013	RC03323,RC03324	ko00000,ko00001,ko01000	-	-	-	FGE-sulfatase,Pkinase
REGS1_k127_7232462_1	177437.HRM2_25590	6.594e-43	162.0	2E1XZ@1|root,32X6W@2|Bacteria,1N6BA@1224|Proteobacteria,42UBW@68525|delta/epsilon subdivisions,2WR12@28221|Deltaproteobacteria,2MKEJ@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_7232462_2	1167006.UWK_01787	2.748e-38	150.0	COG2770@1|root,COG2770@2|Bacteria,1R08R@1224|Proteobacteria,43CRE@68525|delta/epsilon subdivisions,2X7Z3@28221|Deltaproteobacteria,2MPM2@213118|Desulfobacterales	28221|Deltaproteobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_7232462_3	177437.HRM2_25610	1.548e-36	147.0	COG0760@1|root,COG0760@2|Bacteria,1RM0I@1224|Proteobacteria,42SHK@68525|delta/epsilon subdivisions,2WPY4@28221|Deltaproteobacteria,2MKD9@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_7257025_2	1123376.AUIU01000007_gene1192	1.71e-16	87.0	COG2976@1|root,COG2976@2|Bacteria,3J1C7@40117|Nitrospirae	40117|Nitrospirae	S	Tetratricopeptide repeat-like domain	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_7257025_0	1123376.AUIU01000012_gene1443	2.07e-111	373.0	COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,3J0J4@40117|Nitrospirae	40117|Nitrospirae	M	Lysin motif	-	-	-	ko:K08307	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	LysM,SLT
REGS1_k127_7257025_1	1123371.ATXH01000004_gene1782	6.366e-42	159.0	COG5483@1|root,COG5483@2|Bacteria,2GI0U@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	Protein of unknown function, DUF488	-	-	-	-	-	-	-	-	-	-	-	-	DUF488
REGS1_k127_7288204_11	204669.Acid345_2497	4.752e-16	91.0	COG2203@1|root,COG2204@1|root,COG4191@1|root,COG2203@2|Bacteria,COG2204@2|Bacteria,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K02482,ko:K03557	ko05111,map05111	-	-	-	ko00000,ko00001,ko01000,ko01001,ko02022,ko03000,ko03036,ko03400	-	-	-	GAF,GAF_2,HATPase_c,HTH_8,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,RsbRD_N
REGS1_k127_7288204_10	909663.KI867150_gene615	1.621e-17	84.0	COG2608@1|root,COG2608@2|Bacteria	2|Bacteria	P	mercury ion transmembrane transporter activity	-	-	-	ko:K07213	ko04978,map04978	-	-	-	ko00000,ko00001	-	-	-	HMA
REGS1_k127_7288204_3	269799.Gmet_1005	5.083e-95	339.0	COG2202@1|root,COG2203@1|root,COG4251@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG4251@2|Bacteria,1NWNJ@1224|Proteobacteria,43C40@68525|delta/epsilon subdivisions,2X7EG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
REGS1_k127_7288204_5	1220534.B655_1971	2.87e-45	187.0	arCOG02348@1|root,arCOG02353@1|root,arCOG03567@1|root,arCOG02348@2157|Archaea,arCOG02353@2157|Archaea,arCOG03567@2157|Archaea	2157|Archaea	T	signal transduction histidine kinase	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	GAF,GAF_2,HATPase_c,HisKA,HisKA_2,MEDS,PAS,PAS_3,PAS_4,PAS_9,Response_reg
REGS1_k127_7288204_1	555079.Toce_1396	4.651e-149	495.0	COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,1TP98@1239|Firmicutes,248BJ@186801|Clostridia,42F4K@68295|Thermoanaerobacterales	186801|Clostridia	J	phenylalanyl-tRNA synthetase (beta subunit)	pheT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA-synt_2d,tRNA_bind
REGS1_k127_7288204_2	289376.THEYE_A1417	3.048e-143	461.0	COG0016@1|root,COG0016@2|Bacteria,3J0SW@40117|Nitrospirae	40117|Nitrospirae	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
REGS1_k127_7288204_6	1123376.AUIU01000005_gene1224	1.808e-39	150.0	COG0292@1|root,COG0292@2|Bacteria,3J0SF@40117|Nitrospirae	40117|Nitrospirae	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015934,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
REGS1_k127_7288204_9	156889.Mmc1_0365	1.705e-18	88.0	COG0291@1|root,COG0291@2|Bacteria	2|Bacteria	J	Belongs to the bacterial ribosomal protein bL35 family	rpmI	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02916	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35p
REGS1_k127_7288204_4	1262914.BN533_01985	1.099e-50	185.0	COG0290@1|root,COG0290@2|Bacteria,1V1RC@1239|Firmicutes,4H3YT@909932|Negativicutes	909932|Negativicutes	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	-	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
REGS1_k127_7288204_0	289376.THEYE_A1229	9.556e-286	889.0	COG0441@1|root,COG0441@2|Bacteria,3J0F4@40117|Nitrospirae	40117|Nitrospirae	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_SAD
REGS1_k127_7288204_7	243231.GSU3030	7.499e-36	151.0	COG2159@1|root,COG2159@2|Bacteria,1R7E1@1224|Proteobacteria,42NK6@68525|delta/epsilon subdivisions,2WR4B@28221|Deltaproteobacteria,43UAR@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
REGS1_k127_7288204_12	883.DvMF_3060	1.197e-11	68.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,42MXI@68525|delta/epsilon subdivisions,2WIX9@28221|Deltaproteobacteria,2M810@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	Chemotaxis sensory transducer	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	MCPsignal,PAS_4,PAS_9
REGS1_k127_7288204_8	1254432.SCE1572_48725	9.988e-20	95.0	2DE4Z@1|root,2ZKI5@2|Bacteria,1RCRV@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_7288204_14	1116472.MGMO_85c00430	7.437e-05	47.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
REGS1_k127_7295009_1	335543.Sfum_3516	4.864e-190	599.0	COG0008@1|root,COG0008@2|Bacteria,1MUC8@1224|Proteobacteria,42MAX@68525|delta/epsilon subdivisions,2WJ5B@28221|Deltaproteobacteria,2MQTV@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	tRNA synthetases class I (E and Q), anti-codon binding domain	glnS	-	6.1.1.18	ko:K01886	ko00970,ko01100,map00970,map01100	M00359,M00360	R03652	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	GatB_Yqey,tRNA-synt_1c,tRNA-synt_1c_C
REGS1_k127_7295009_0	1123376.AUIU01000015_gene420	3.701e-200	633.0	COG0008@1|root,COG0008@2|Bacteria,3J0CJ@40117|Nitrospirae	40117|Nitrospirae	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
REGS1_k127_7295009_2	289376.THEYE_A0896	9.145e-143	467.0	COG0037@1|root,COG0037@2|Bacteria,3J0SX@40117|Nitrospirae	40117|Nitrospirae	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3,TilS_C
REGS1_k127_7319733_0	497964.CfE428DRAFT_5946	2.581e-55	201.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
REGS1_k127_7319733_2	195103.CPF_0326	4.021e-33	134.0	COG0350@1|root,COG0350@2|Bacteria,1VA03@1239|Firmicutes,24JAA@186801|Clostridia,36JKF@31979|Clostridiaceae	186801|Clostridia	L	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated	ogt	-	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1,Methyltransf_1N
REGS1_k127_7319733_1	123214.PERMA_0360	3.021e-33	130.0	COG0780@1|root,COG0780@2|Bacteria,2G4AN@200783|Aquificae	200783|Aquificae	H	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)	queF	-	1.7.1.13	ko:K09457	ko00790,ko01100,map00790,map01100	-	R07605	RC01875	ko00000,ko00001,ko01000,ko03016	-	-	-	QueF
REGS1_k127_7321705_2	375286.mma_1938	6.874e-54	192.0	COG0346@1|root,COG0346@2|Bacteria,1RH3J@1224|Proteobacteria,2VRD4@28216|Betaproteobacteria,477DK@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	gloA3	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
REGS1_k127_7321705_1	1123376.AUIU01000003_gene1644	4.38e-102	338.0	COG1476@1|root,COG1476@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	xre	-	-	-	-	-	-	-	-	-	-	-	HTH_3
REGS1_k127_7321705_3	1047013.AQSP01000142_gene217	1.493e-40	154.0	2EDCN@1|root,3378Z@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_7321705_6	1211814.CAPG01000092_gene4229	4.148e-09	57.0	29S0J@1|root,30D4W@2|Bacteria,1UAUR@1239|Firmicutes,4IM7J@91061|Bacilli,1ZJEQ@1386|Bacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_7321705_5	1125863.JAFN01000001_gene3023	2.247e-25	111.0	COG4232@1|root,COG4232@2|Bacteria	2|Bacteria	CO	protein-disulfide reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	DsbC,LGT,Redoxin
REGS1_k127_7321705_0	671143.DAMO_1445	4.737e-214	687.0	COG0417@1|root,COG1205@1|root,COG0417@2|Bacteria,COG1205@2|Bacteria,2NNKJ@2323|unclassified Bacteria	2|Bacteria	L	Domain of unknown function (DUF1998)	yprA	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360	2.7.7.7	ko:K02336,ko:K06877	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DNA_pol_B,DNA_pol_B_exo1,DUF1998,Helicase_C
REGS1_k127_7321705_4	645991.Sgly_3281	1.051e-39	151.0	COG2131@1|root,COG2131@2|Bacteria,1V3PU@1239|Firmicutes,24HF0@186801|Clostridia,261R0@186807|Peptococcaceae	186801|Clostridia	F	PFAM Cytidine and deoxycytidylate deaminase zinc-binding region	comEB	-	3.5.4.12	ko:K01493	ko00240,ko01100,map00240,map01100	M00429	R01663	RC00074	ko00000,ko00001,ko00002,ko01000,ko02044	-	-	-	dCMP_cyt_deam_1
REGS1_k127_7357566_1	289376.THEYE_A0461	2.175e-57	204.0	COG0414@1|root,COG0414@2|Bacteria,3J0KR@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate	panC	GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_ligase
REGS1_k127_7357566_0	289376.THEYE_A1974	5.676e-174	565.0	COG2871@1|root,COG3894@1|root,COG2871@2|Bacteria,COG3894@2|Bacteria	2|Bacteria	C	2Fe-2S iron-sulfur cluster binding domain	nqrF	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
REGS1_k127_7371002_2	706587.Desti_1408	6.689e-05	49.0	COG2852@1|root,COG2852@2|Bacteria,1N0QU@1224|Proteobacteria,42W6Y@68525|delta/epsilon subdivisions,2WRWM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Protein of unknown function (DUF559)	-	-	-	-	-	-	-	-	-	-	-	-	DUF559
REGS1_k127_7371002_0	1232410.KI421415_gene3082	1.372e-31	126.0	COG1193@1|root,COG1193@2|Bacteria,1NCS6@1224|Proteobacteria,42VGJ@68525|delta/epsilon subdivisions,2WRA6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM Smr protein MutS2	-	-	-	-	-	-	-	-	-	-	-	-	Smr
REGS1_k127_7371002_1	1129374.AJE_11674	6.118e-27	112.0	COG0564@1|root,COG0564@2|Bacteria,1R4IN@1224|Proteobacteria,1S0WR@1236|Gammaproteobacteria,466SG@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	COG0564 Pseudouridylate synthases, 23S RNA-specific	-	-	5.4.99.28,5.4.99.29	ko:K06177	-	-	-	-	ko00000,ko01000,ko03009,ko03016	-	-	-	PseudoU_synth_2
REGS1_k127_739924_0	1123009.AUID01000001_gene1054	2.274e-98	334.0	COG1245@1|root,COG2878@1|root,COG1245@2|Bacteria,COG2878@2|Bacteria,1TQGD@1239|Firmicutes,24904@186801|Clostridia,268S4@186813|unclassified Clostridiales	186801|Clostridia	C	Putative Fe-S cluster	rnfB	-	-	ko:K03616	-	-	-	-	ko00000	-	-	-	FeS,Fer4,Fer4_13,Fer4_4,Fer4_9
REGS1_k127_739924_1	706587.Desti_2906	2.043e-65	228.0	COG4657@1|root,COG4657@2|Bacteria,1MU8X@1224|Proteobacteria,42MCM@68525|delta/epsilon subdivisions,2WKRE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Part of a membrane complex involved in electron transport	rnfA	-	-	ko:K03617	-	-	-	-	ko00000	-	-	-	Rnf-Nqr
REGS1_k127_7427732_0	289376.THEYE_A1980	3.885e-150	499.0	COG1674@1|root,COG1674@2|Bacteria,3J0BQ@40117|Nitrospirae	40117|Nitrospirae	D	Ftsk_gamma	ftsK	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
REGS1_k127_7427732_1	289376.THEYE_A1979	1.024e-84	287.0	COG1968@1|root,COG1968@2|Bacteria,3J0S7@40117|Nitrospirae	40117|Nitrospirae	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP)	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
REGS1_k127_7427732_2	1463887.KL589982_gene4661	5.473e-53	193.0	COG4257@1|root,COG4257@2|Bacteria,2GJU3@201174|Actinobacteria	201174|Actinobacteria	V	Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid	-	-	-	ko:K18235	-	-	-	-	ko00000,ko01000,ko01504	-	-	-	DUF11
REGS1_k127_7432374_0	1123376.AUIU01000019_gene1247	1.364e-196	630.0	COG5009@1|root,COG5009@2|Bacteria,3J0BH@40117|Nitrospirae	40117|Nitrospirae	M	Penicillin-binding protein OB-like domain	-	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	PCB_OB,Transgly,Transpeptidase
REGS1_k127_7432374_14	335543.Sfum_0360	1.062e-34	137.0	COG0789@1|root,COG0789@2|Bacteria,1NP97@1224|Proteobacteria,43DNH@68525|delta/epsilon subdivisions,2X38J@28221|Deltaproteobacteria,2MSE8@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	Transcriptional regulator, MerR family	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
REGS1_k127_7432374_9	289376.THEYE_A1530	1.765e-68	239.0	COG0356@1|root,COG0356@2|Bacteria,3J0RW@40117|Nitrospirae	40117|Nitrospirae	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
REGS1_k127_7432374_16	1121413.JMKT01000008_gene1424	6.199e-22	99.0	COG0636@1|root,COG0636@2|Bacteria,1NAIE@1224|Proteobacteria,42VAI@68525|delta/epsilon subdivisions,2WRI4@28221|Deltaproteobacteria,2MCKI@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpE	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_C
REGS1_k127_7432374_8	1121121.KB894298_gene3983	1.63e-69	241.0	COG2258@1|root,COG2258@2|Bacteria,1UB2C@1239|Firmicutes,4HB26@91061|Bacilli,26T6I@186822|Paenibacillaceae	91061|Bacilli	S	MOSC domain	-	-	-	-	-	-	-	-	-	-	-	-	3-alpha,MOSC
REGS1_k127_7432374_17	338963.Pcar_2636	7.077e-21	95.0	COG2501@1|root,COG2501@2|Bacteria,1N7NW@1224|Proteobacteria,42W9B@68525|delta/epsilon subdivisions,2WS2I@28221|Deltaproteobacteria,43SRM@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	S4 domain	-	-	-	ko:K14761	-	-	-	-	ko00000,ko03009	-	-	-	S4_2
REGS1_k127_7432374_4	880072.Desac_2749	1.336e-95	339.0	COG2203@1|root,COG3605@1|root,COG2203@2|Bacteria,COG3605@2|Bacteria,1RHTM@1224|Proteobacteria,43F2G@68525|delta/epsilon subdivisions,2X340@28221|Deltaproteobacteria,2MRSC@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2
REGS1_k127_7432374_15	485913.Krac_8187	4.485e-23	115.0	COG2203@1|root,COG2203@2|Bacteria	2|Bacteria	T	Gaf domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2
REGS1_k127_7432374_19	1304885.AUEY01000017_gene3733	1.057e-05	59.0	COG2202@1|root,COG4191@1|root,COG2202@2|Bacteria,COG4191@2|Bacteria,1N47P@1224|Proteobacteria,42W9J@68525|delta/epsilon subdivisions,2WSBM@28221|Deltaproteobacteria,2MKZR@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	PAS_3
REGS1_k127_7432374_18	398767.Glov_2700	4.45e-19	102.0	COG2199@1|root,COG3706@2|Bacteria,1RAKG@1224|Proteobacteria,42QYD@68525|delta/epsilon subdivisions,2WN6A@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,PAS_9
REGS1_k127_7432374_12	485915.Dret_0857	1.827e-47	180.0	COG1418@1|root,COG1418@2|Bacteria,1RGCM@1224|Proteobacteria,42RC5@68525|delta/epsilon subdivisions,2WNBA@28221|Deltaproteobacteria,2MBBU@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	mRNA catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	HD
REGS1_k127_7432374_6	269799.Gmet_1388	1.098e-88	302.0	COG0196@1|root,COG0196@2|Bacteria,1MV9I@1224|Proteobacteria,42MV7@68525|delta/epsilon subdivisions,2WJTU@28221|Deltaproteobacteria,43S5P@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	TIGRFAM riboflavin biosynthesis protein RibF	ribF	-	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
REGS1_k127_7432374_13	351160.RRC41	1.226e-36	144.0	COG0529@1|root,arCOG01040@2157|Archaea,2XU4H@28890|Euryarchaeota,2NBDX@224756|Methanomicrobia	224756|Methanomicrobia	P	Adenylylsulphate kinase	cysC	-	2.7.1.25	ko:K00860	ko00230,ko00920,ko01100,ko01120,map00230,map00920,map01100,map01120	M00176	R00509,R04928	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase
REGS1_k127_7432374_10	316067.Geob_1869	4.704e-66	250.0	COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,42N34@68525|delta/epsilon subdivisions,2WJUD@28221|Deltaproteobacteria,43TYF@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane	lptD	-	-	ko:K04744	-	-	-	-	ko00000,ko02000	1.B.42.1	-	iAF987.Gmet_2474	OstA,OstA_2,OstA_C
REGS1_k127_7432374_3	335543.Sfum_1671	1.357e-103	353.0	COG0285@1|root,COG0285@2|Bacteria,1MVCH@1224|Proteobacteria,42N08@68525|delta/epsilon subdivisions,2WIW9@28221|Deltaproteobacteria,2MQBB@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Mur ligase, middle domain	folC	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2475	Mur_ligase_C,Mur_ligase_M
REGS1_k127_7432374_2	289376.THEYE_A0559	1.326e-121	395.0	COG0777@1|root,COG0777@2|Bacteria,3J0CK@40117|Nitrospirae	40117|Nitrospirae	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA	accD	-	2.1.3.15,6.4.1.2	ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
REGS1_k127_7432374_5	316067.Geob_2688	2.814e-91	306.0	COG1234@1|root,COG1234@2|Bacteria,1QU4B@1224|Proteobacteria,42SHU@68525|delta/epsilon subdivisions,2WPGG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	cAMP phosphodiesterases class-II	-	-	3.1.4.17	ko:K01120	ko00230,map00230	-	R00191,R01234	RC00296	ko00000,ko00001,ko01000	-	-	-	Lactamase_B_2,PDEase_II
REGS1_k127_7432374_1	289376.THEYE_A2006	1.12e-129	424.0	COG2203@1|root,COG2206@1|root,COG2203@2|Bacteria,COG2206@2|Bacteria,3J18S@40117|Nitrospirae	40117|Nitrospirae	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_7432374_7	289376.THEYE_A0560	4.326e-83	284.0	COG0159@1|root,COG0159@2|Bacteria,3J0ME@40117|Nitrospirae	40117|Nitrospirae	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
REGS1_k127_7432374_11	289376.THEYE_A0561	1.312e-58	205.0	COG0133@1|root,COG0133@2|Bacteria,3J0E1@40117|Nitrospirae	40117|Nitrospirae	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
REGS1_k127_7441490_1	330214.NIDE0419	2.621e-127	416.0	COG0077@1|root,COG1605@1|root,COG0077@2|Bacteria,COG1605@2|Bacteria,3J0A9@40117|Nitrospirae	40117|Nitrospirae	E	Chorismate mutase type II	-	-	4.2.1.51,5.4.99.5	ko:K14170	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R00691,R01373,R01715	RC00360,RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,CM_2,PDT
REGS1_k127_7441490_0	289376.THEYE_A1764	9.456e-132	430.0	COG0079@1|root,COG0079@2|Bacteria,3J0XY@40117|Nitrospirae	40117|Nitrospirae	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
REGS1_k127_7441490_2	1123376.AUIU01000011_gene855	4.346e-33	130.0	COG2876@1|root,COG2876@2|Bacteria,3J0A5@40117|Nitrospirae	40117|Nitrospirae	E	NeuB family	-	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
REGS1_k127_7444054_1	56780.SYN_00061	2.743e-107	370.0	COG5002@1|root,COG5002@2|Bacteria,1MWF3@1224|Proteobacteria,42NB5@68525|delta/epsilon subdivisions,2WJGX@28221|Deltaproteobacteria,2MQCA@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	Signal transduction histidine kinase	phoR	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_8,sCache_like
REGS1_k127_7444054_2	161156.JQKW01000012_gene55	4.686e-85	287.0	COG0745@1|root,COG0745@2|Bacteria,2GH4D@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	T	Transcriptional regulatory protein, C terminal	-	-	-	ko:K07657	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
REGS1_k127_7444054_0	243233.MCA2606	3.138e-240	749.0	COG0297@1|root,COG0297@2|Bacteria,1P7F2@1224|Proteobacteria,1RZVJ@1236|Gammaproteobacteria,1XG73@135618|Methylococcales	135618|Methylococcales	G	Starch synthase catalytic domain	-	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009011,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0046527,GO:0055114,GO:0071704,GO:1901576	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
REGS1_k127_7444054_3	292415.Tbd_2614	4.988e-13	80.0	COG0589@1|root,COG0589@2|Bacteria,1MZ3K@1224|Proteobacteria,2VSW6@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
REGS1_k127_7453660_0	404380.Gbem_0265	2.582e-196	624.0	COG1387@1|root,COG1387@2|Bacteria,1MYXV@1224|Proteobacteria,42MQX@68525|delta/epsilon subdivisions,2WKUP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	DNA polymerase	-	-	-	ko:K02347	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_palm,DNA_pol_B_thumb,HHH_5,HHH_8,PHP
REGS1_k127_7453688_2	324925.Ppha_1259	0.0001697	46.0	COG1512@1|root,COG1512@2|Bacteria,1FENY@1090|Chlorobi	1090|Chlorobi	S	TPM domain	-	-	-	ko:K06872	-	-	-	-	ko00000	-	-	-	TPM_phosphatase
REGS1_k127_7453688_1	324925.Ppha_1258	1.674e-56	205.0	COG3762@1|root,COG3762@2|Bacteria,1FEPE@1090|Chlorobi	1090|Chlorobi	S	TPM domain	-	-	-	-	-	-	-	-	-	-	-	-	TPM_phosphatase
REGS1_k127_7453688_0	289376.THEYE_A1816	2.288e-245	770.0	COG3158@1|root,COG3158@2|Bacteria,3J0YF@40117|Nitrospirae	40117|Nitrospirae	P	Transport of potassium into the cell	kup	-	-	ko:K03549	-	-	-	-	ko00000,ko02000	2.A.72	-	-	K_trans
REGS1_k127_7458163_8	1121396.KB892990_gene4479	1.389e-07	53.0	COG0730@1|root,COG0730@2|Bacteria,1MWX2@1224|Proteobacteria,42R15@68525|delta/epsilon subdivisions,2WJR6@28221|Deltaproteobacteria,2MIHT@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
REGS1_k127_7458163_3	1123371.ATXH01000001_gene1240	5.513e-47	179.0	2AFUA@1|root,315WQ@2|Bacteria,2GIA0@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	Putative transmembrane protein (Alph_Pro_TM)	-	-	-	-	-	-	-	-	-	-	-	-	Alph_Pro_TM
REGS1_k127_7458163_5	797299.HALLA_03675	5.523e-34	143.0	COG0589@1|root,arCOG00449@2157|Archaea,2XU1E@28890|Euryarchaeota,23TYX@183963|Halobacteria	183963|Halobacteria	T	COG0589 Universal stress protein UspA and related nucleotide-binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Usp
REGS1_k127_7458163_7	416348.Hlac_1467	4.568e-09	64.0	COG0589@1|root,arCOG02053@2157|Archaea,2XX8Y@28890|Euryarchaeota,23VQJ@183963|Halobacteria	183963|Halobacteria	T	COG0589 Universal stress protein UspA and related nucleotide-binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Usp
REGS1_k127_7458163_0	637390.AFOH01000110_gene2869	9.864e-136	450.0	2BH64@1|root,33QKM@2|Bacteria,1NR5U@1224|Proteobacteria,1T8UM@1236|Gammaproteobacteria,2NDG0@225057|Acidithiobacillales	225057|Acidithiobacillales	S	Type II secretion system (T2SS), protein E, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	T2SSE_N
REGS1_k127_7458163_2	637389.Acaty_c2637	3.723e-103	352.0	COG3071@1|root,COG3071@2|Bacteria,1NX21@1224|Proteobacteria,1TE02@1236|Gammaproteobacteria,2NDG3@225057|Acidithiobacillales	225057|Acidithiobacillales	H	Type II secretion system (T2SS), protein E, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	T2SSE_N
REGS1_k127_7458163_1	941449.dsx2_2995	2.664e-122	409.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,439Y6@68525|delta/epsilon subdivisions,2X1VE@28221|Deltaproteobacteria,2M9ND@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	histidine kinase HAMP region domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
REGS1_k127_7458163_4	596152.DesU5LDRAFT_0905	2.5e-44	165.0	COG2204@1|root,COG2204@2|Bacteria,1PZDN@1224|Proteobacteria,435WZ@68525|delta/epsilon subdivisions,2X0DD@28221|Deltaproteobacteria,2MBWS@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	PFAM response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
REGS1_k127_7458163_6	1121396.KB892990_gene4477	3.21e-30	128.0	COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,1QFX3@1224|Proteobacteria,42PIP@68525|delta/epsilon subdivisions,2WKWI@28221|Deltaproteobacteria,2MIZ0@213118|Desulfobacterales	28221|Deltaproteobacteria	GT	PEP-utilising enzyme, mobile domain	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
REGS1_k127_7459342_3	358220.C380_13165	3.485e-65	231.0	COG1680@1|root,COG1680@2|Bacteria,1MVPR@1224|Proteobacteria,2VPXX@28216|Betaproteobacteria	28216|Betaproteobacteria	V	beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
REGS1_k127_7459342_5	521011.Mpal_1200	6.595e-34	137.0	COG0778@1|root,arCOG00288@2157|Archaea,2XYAZ@28890|Euryarchaeota,2N9WV@224756|Methanomicrobia	224756|Methanomicrobia	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
REGS1_k127_7459342_6	1123376.AUIU01000015_gene438	1.052e-30	121.0	COG1278@1|root,COG1278@2|Bacteria,3J0QZ@40117|Nitrospirae	40117|Nitrospirae	K	'Cold-shock' DNA-binding domain	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
REGS1_k127_7459342_1	933262.AXAM01000019_gene1126	7.961e-101	335.0	COG0320@1|root,COG0320@2|Bacteria,1MVRD@1224|Proteobacteria,42P2E@68525|delta/epsilon subdivisions,2WIJQ@28221|Deltaproteobacteria,2MIZC@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	-	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
REGS1_k127_7459342_8	289376.THEYE_A1985	1.523e-13	74.0	COG0436@1|root,COG0436@2|Bacteria,3J0ED@40117|Nitrospirae	40117|Nitrospirae	E	Aminotransferase class I and II	-	-	-	ko:K14261	-	-	-	-	ko00000,ko01000,ko01007	-	-	-	Aminotran_1_2
REGS1_k127_7459342_0	289376.THEYE_A1986	1.083e-170	545.0	COG0460@1|root,COG0460@2|Bacteria,3J0G1@40117|Nitrospirae	40117|Nitrospirae	E	Homoserine dehydrogenase	-	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,Homoserine_dh,NAD_binding_3
REGS1_k127_7459342_7	269799.Gmet_2569	5.861e-15	76.0	2EIC1@1|root,33C3D@2|Bacteria,1NHMH@1224|Proteobacteria,42WXS@68525|delta/epsilon subdivisions,2WT9H@28221|Deltaproteobacteria,43VPD@69541|Desulfuromonadales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Rho_N
REGS1_k127_7459342_2	1123376.AUIU01000015_gene482	2.698e-94	319.0	COG1234@1|root,COG1234@2|Bacteria,3J113@40117|Nitrospirae	40117|Nitrospirae	S	tRNA 3'-trailer cleavage	-	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	-
REGS1_k127_7459342_4	1123376.AUIU01000015_gene483	2.327e-41	154.0	COG1085@1|root,COG1085@2|Bacteria,3J0ER@40117|Nitrospirae	40117|Nitrospirae	H	Galactose-1-phosphate uridyl transferase, N-terminal domain	galT	-	2.7.7.12	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	M00362,M00554,M00632	R00955	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	GalP_UDP_tr_C,GalP_UDP_transf
REGS1_k127_7465298_5	316067.Geob_3740	1.638e-15	89.0	COG3880@1|root,COG3880@2|Bacteria	2|Bacteria	E	PFAM UvrB UvrC protein	mcsA	GO:0003674,GO:0005488,GO:0005507,GO:0006950,GO:0008150,GO:0008270,GO:0010035,GO:0010038,GO:0042221,GO:0043167,GO:0043169,GO:0046686,GO:0046688,GO:0046870,GO:0046872,GO:0046914,GO:0050896,GO:0050897,GO:0097501,GO:1990169,GO:1990170	2.7.14.1	ko:K08999,ko:K19405,ko:K19411	-	-	R11090	RC00002,RC00203	ko00000,ko01000	-	-	-	Cytochrom_CIII,Cytochrome_C7,UVR
REGS1_k127_7465298_0	330214.NIDE0999	3.661e-173	548.0	COG0059@1|root,COG0059@2|Bacteria,3J0DW@40117|Nitrospirae	40117|Nitrospirae	H	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
REGS1_k127_7465298_2	289376.THEYE_A0652	6.572e-60	215.0	COG0688@1|root,COG0688@2|Bacteria,3J0KD@40117|Nitrospirae	40117|Nitrospirae	I	Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer)	psd	-	4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PS_Dcarbxylase
REGS1_k127_7465298_4	865861.AZSU01000005_gene876	2.377e-26	111.0	COG0261@1|root,COG0261@2|Bacteria,1V9YH@1239|Firmicutes,24MRS@186801|Clostridia,36JGP@31979|Clostridiaceae	186801|Clostridia	J	This protein binds to 23S rRNA in the presence of protein L20	rplU	-	-	ko:K02888	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21p
REGS1_k127_7465298_3	1173026.Glo7428_2814	2.247e-41	153.0	COG0211@1|root,COG0211@2|Bacteria,1G7RW@1117|Cyanobacteria	1117|Cyanobacteria	J	Belongs to the bacterial ribosomal protein bL27 family	rpmA	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
REGS1_k127_7465298_1	289376.THEYE_A0433	7.144e-147	471.0	COG0536@1|root,COG0536@2|Bacteria,3J0E3@40117|Nitrospirae	40117|Nitrospirae	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	GTP1_OBG,MMR_HSR1
REGS1_k127_7475928_2	881621.LIV_1819	3.512e-22	100.0	COG0564@1|root,COG0564@2|Bacteria,1TPCM@1239|Firmicutes,4HBG2@91061|Bacilli,26JB4@186820|Listeriaceae	91061|Bacilli	J	Responsible for synthesis of pseudouridine from uracil	rluD	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
REGS1_k127_7475928_0	717785.HYPMC_4901	1.546e-54	198.0	COG0705@1|root,COG0705@2|Bacteria,1MYFP@1224|Proteobacteria,2TSJG@28211|Alphaproteobacteria,3N8E7@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
REGS1_k127_7475928_1	1173028.ANKO01000041_gene3170	2.187e-52	199.0	COG0745@1|root,COG5002@1|root,COG0745@2|Bacteria,COG5002@2|Bacteria,1GHFQ@1117|Cyanobacteria	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	2.1.1.80,3.1.1.61	ko:K13924	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	HATPase_c,HisKA,Hpt,PAS,PAS_4,Response_reg
REGS1_k127_7476747_1	1131266.ARWQ01000013_gene69	2.895e-25	113.0	COG1032@1|root,arCOG01356@2157|Archaea	2157|Archaea	C	SMART Elongator protein 3 MiaB NifB	-	-	1.21.98.3	ko:K04034	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R06268,R06269,R06270	RC00741,RC01491,RC01492	ko00000,ko00001,ko01000	-	-	-	B12-binding,Radical_SAM
REGS1_k127_7476747_3	641526.ADIWIN_1285	2.801e-07	64.0	COG4485@1|root,COG4485@2|Bacteria,4NEE5@976|Bacteroidetes,1HX3C@117743|Flavobacteriia	976|Bacteroidetes	S	PFAM Bacterial membrane protein YfhO	-	-	-	-	-	-	-	-	-	-	-	-	YfhO
REGS1_k127_7476747_2	96561.Dole_2512	1.489e-17	87.0	COG3086@1|root,COG3086@2|Bacteria,1PKXC@1224|Proteobacteria,42UU9@68525|delta/epsilon subdivisions,2WPMZ@28221|Deltaproteobacteria,2MK8X@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM Positive regulator of sigma(E) RseC MucC	-	-	-	ko:K03803	-	-	-	-	ko00000,ko03021	-	-	-	RseC_MucC
REGS1_k127_7476747_0	289376.THEYE_A0554	7.077e-131	426.0	COG0480@1|root,COG0480@2|Bacteria,3J0WU@40117|Nitrospirae	40117|Nitrospirae	J	Elongation factor G, domain IV	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
REGS1_k127_7501062_3	563192.HMPREF0179_03137	3.583e-83	280.0	COG0204@1|root,COG0204@2|Bacteria,1PY44@1224|Proteobacteria,42NR4@68525|delta/epsilon subdivisions,2WKKQ@28221|Deltaproteobacteria,2MAGC@213115|Desulfovibrionales	28221|Deltaproteobacteria	I	PFAM Phospholipid glycerol acyltransferase	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
REGS1_k127_7501062_5	443143.GM18_3041	2.116e-20	93.0	COG1051@1|root,COG1051@2|Bacteria	2|Bacteria	F	GDP-mannose mannosyl hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
REGS1_k127_7501062_6	589865.DaAHT2_0648	2.549e-12	72.0	COG0834@1|root,COG2204@1|root,COG4191@1|root,COG0834@2|Bacteria,COG2204@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42M1R@68525|delta/epsilon subdivisions,2WK3J@28221|Deltaproteobacteria,2MI5F@213118|Desulfobacterales	28221|Deltaproteobacteria	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,SBP_bac_3
REGS1_k127_7501062_1	289376.THEYE_A0589	2.281e-147	492.0	COG0671@1|root,COG1807@1|root,COG0671@2|Bacteria,COG1807@2|Bacteria,3J155@40117|Nitrospirae	40117|Nitrospirae	I	Acid phosphatase homologues	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2,PMT_2
REGS1_k127_7501062_2	289376.THEYE_A0588	2.725e-144	463.0	COG0463@1|root,COG0463@2|Bacteria,3J13C@40117|Nitrospirae	40117|Nitrospirae	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
REGS1_k127_7501062_4	289376.THEYE_A0587	2.122e-42	167.0	COG0392@1|root,COG0392@2|Bacteria	2|Bacteria	M	lysyltransferase activity	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
REGS1_k127_7501062_0	1134413.ANNK01000089_gene367	1.571e-157	511.0	COG0161@1|root,COG0161@2|Bacteria,1TP9N@1239|Firmicutes,4H9QK@91061|Bacilli,1ZR67@1386|Bacillus	91061|Bacilli	H	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor	bioA	-	2.6.1.105,2.6.1.62	ko:K00833,ko:K19563	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03231,R10699	RC00006,RC00062,RC00887	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iSB619.SA_RS12705	Aminotran_3
REGS1_k127_7507899_0	289376.THEYE_A0592	1.682e-144	470.0	COG1030@1|root,COG1030@2|Bacteria,3J0WF@40117|Nitrospirae	40117|Nitrospirae	O	NfeD-like C-terminal, partner-binding	-	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	NfeD
REGS1_k127_7507899_1	289376.THEYE_A1475	1.172e-114	386.0	COG0330@1|root,COG0330@2|Bacteria,3J0NF@40117|Nitrospirae	40117|Nitrospirae	O	prohibitin homologues	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
REGS1_k127_752700_2	338963.Pcar_1177	2.299e-79	282.0	COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,42T0Q@68525|delta/epsilon subdivisions,2WUA0@28221|Deltaproteobacteria,43SZX@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	diguanylate cyclase	-	-	2.7.7.65	ko:K02488	ko02020,ko04112,map02020,map04112	M00511	R08057	-	ko00000,ko00001,ko00002,ko01000,ko02022	-	-	-	GAF_2,GGDEF,Response_reg
REGS1_k127_752700_0	289376.THEYE_A1552	3.518e-265	844.0	COG0517@1|root,COG0617@1|root,COG0618@1|root,COG0517@2|Bacteria,COG0617@2|Bacteria,COG0618@2|Bacteria,3J0NX@40117|Nitrospirae	40117|Nitrospirae	J	Probable RNA and SrmB- binding site of polymerase A	-	-	2.7.7.72	ko:K00974	ko03013,map03013	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	CBS,DHH,DHHA1,PolyA_pol,PolyA_pol_RNAbd
REGS1_k127_752700_1	96561.Dole_1136	6.421e-117	391.0	COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,42QB7@68525|delta/epsilon subdivisions,2WM6Y@28221|Deltaproteobacteria,2MHYS@213118|Desulfobacterales	28221|Deltaproteobacteria	T	metal-dependent phosphohydrolase HD region	-	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	HD,HD_5,Response_reg
REGS1_k127_752700_3	909663.KI867150_gene185	5.314e-39	148.0	COG1871@1|root,COG1871@2|Bacteria,1RDDB@1224|Proteobacteria,42S9S@68525|delta/epsilon subdivisions,2WNSD@28221|Deltaproteobacteria,2MQQV@213462|Syntrophobacterales	28221|Deltaproteobacteria	NT	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis	cheD2	-	3.5.1.44	ko:K03411	ko02030,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheD
REGS1_k127_7558884_0	289376.THEYE_A1303	5.559e-114	375.0	COG1858@1|root,COG1858@2|Bacteria,3J0GH@40117|Nitrospirae	40117|Nitrospirae	C	Di-haem cytochrome c peroxidase	-	-	1.11.1.5	ko:K00428	-	-	-	-	ko00000,ko01000	-	-	-	CCP_MauG,Cytochrom_C
REGS1_k127_7558884_1	289376.THEYE_A1305	1.272e-44	166.0	COG1651@1|root,COG1651@2|Bacteria,3J19Z@40117|Nitrospirae	40117|Nitrospirae	O	DSBA-like thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_7599879_1	289376.THEYE_A0953	2.695e-126	407.0	COG0568@1|root,COG0568@2|Bacteria,3J0E4@40117|Nitrospirae	40117|Nitrospirae	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
REGS1_k127_7599879_3	1123376.AUIU01000004_gene1150	2.752e-14	74.0	COG0568@1|root,COG0568@2|Bacteria,3J0E4@40117|Nitrospirae	40117|Nitrospirae	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
REGS1_k127_7599879_0	1191523.MROS_1494	8.586e-130	428.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	-	-	-	ko:K07714	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
REGS1_k127_7599879_2	1191523.MROS_1493	2.387e-54	215.0	COG4191@1|root,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_9,Response_reg
REGS1_k127_7606832_8	909663.KI867150_gene15	4.866e-95	319.0	COG0430@1|root,COG0430@2|Bacteria,1MX7Q@1224|Proteobacteria,42MZG@68525|delta/epsilon subdivisions,2WKZ3@28221|Deltaproteobacteria,2MQFQ@213462|Syntrophobacterales	28221|Deltaproteobacteria	A	Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP	rtcA	-	6.5.1.4	ko:K01974	-	-	-	-	ko00000,ko01000	-	-	-	RTC,RTC_insert
REGS1_k127_7606832_1	289376.THEYE_A0012	1.017e-157	513.0	COG0815@1|root,COG0815@2|Bacteria,3J0HA@40117|Nitrospirae	40117|Nitrospirae	M	Carbon-nitrogen hydrolase	lnt	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
REGS1_k127_7606832_2	1158318.ATXC01000001_gene1139	2.64e-123	404.0	COG1186@1|root,COG1186@2|Bacteria,2G3P3@200783|Aquificae	200783|Aquificae	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
REGS1_k127_7606832_3	720554.Clocl_2628	5.197e-117	385.0	COG0547@1|root,COG0547@2|Bacteria,1TP8U@1239|Firmicutes,247WY@186801|Clostridia,3WHFS@541000|Ruminococcaceae	186801|Clostridia	E	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	-	2.4.2.18,4.1.3.27	ko:K00766,ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R00985,R00986,R01073	RC00010,RC00440,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
REGS1_k127_7606832_7	289376.THEYE_A1005	1.202e-105	356.0	COG1906@1|root,COG1906@2|Bacteria	2|Bacteria	C	membrane	-	-	-	ko:K09133	-	-	-	-	ko00000	-	-	-	DUF401
REGS1_k127_7606832_4	717605.Theco_1964	1.718e-115	391.0	COG0497@1|root,COG0497@2|Bacteria,1TP99@1239|Firmicutes,4H9ZR@91061|Bacilli,26R70@186822|Paenibacillaceae	91061|Bacilli	L	May be involved in recombinational repair of damaged DNA	recN	GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0033554,GO:0034641,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,SMC_N
REGS1_k127_7606832_9	391009.Tmel_0105	2.55e-19	90.0	COG1146@1|root,COG1146@2|Bacteria,2GDEK@200918|Thermotogae	200918|Thermotogae	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	1.2.7.3	ko:K00176	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4
REGS1_k127_7606832_6	880073.Calab_2940	2.293e-107	360.0	COG0626@1|root,COG0626@2|Bacteria,2NNNS@2323|unclassified Bacteria	2|Bacteria	E	Cys/Met metabolism PLP-dependent enzyme	-	-	4.4.1.11,4.4.1.8	ko:K01760,ko:K01761	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R00654,R00782,R01286,R02408,R04770,R04941	RC00056,RC00069,RC00196,RC00348,RC00382,RC00488,RC00710,RC01209,RC01210,RC01245,RC02303	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
REGS1_k127_7606832_0	1045855.DSC_07980	2.02e-166	535.0	COG0114@1|root,COG0114@2|Bacteria,1MUQI@1224|Proteobacteria,1RNUS@1236|Gammaproteobacteria,1X3ED@135614|Xanthomonadales	135614|Xanthomonadales	C	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate	fumC	-	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
REGS1_k127_7606832_5	289376.THEYE_A0771	1.738e-109	358.0	COG0479@1|root,COG0479@2|Bacteria,3J14K@40117|Nitrospirae	40117|Nitrospirae	C	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family	-	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_10
REGS1_k127_7657776_0	247490.KSU1_C0472	2.628e-191	606.0	COG0465@1|root,COG0465@2|Bacteria,2IXMI@203682|Planctomycetes	203682|Planctomycetes	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	GO:0003674,GO:0003824,GO:0004176,GO:0005575,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009056,GO:0009057,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0030163,GO:0042623,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
REGS1_k127_7657776_1	909663.KI867150_gene1851	6.377e-30	122.0	COG3357@1|root,COG3357@2|Bacteria,1N7JG@1224|Proteobacteria,42VEP@68525|delta/epsilon subdivisions,2WRD7@28221|Deltaproteobacteria,2MQP0@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	transcriptional regulator containing an HTH domain fused to a Zn-ribbon	-	-	-	ko:K07743	-	-	-	-	ko00000	-	-	-	HTH_5
REGS1_k127_7675290_1	99598.Cal7507_3840	0.0001933	51.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
REGS1_k127_7675290_0	153948.NAL212_3007	2.323e-29	126.0	COG2120@1|root,COG2120@2|Bacteria,1MUTM@1224|Proteobacteria,2VRSH@28216|Betaproteobacteria	28216|Betaproteobacteria	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
REGS1_k127_7676677_0	63737.Npun_R1505	3.778e-133	442.0	COG5001@1|root,COG5002@1|root,COG5001@2|Bacteria,COG5002@2|Bacteria,1G0SY@1117|Cyanobacteria	1117|Cyanobacteria	T	signal transduction protein containing a membrane domain an EAL and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,MHYT,PAS,PAS_9
REGS1_k127_7676677_8	247490.KSU1_D0270	8.959e-12	68.0	COG4634@1|root,COG4634@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_7676677_5	1121405.dsmv_2051	3.698e-64	229.0	COG2129@1|root,COG2129@2|Bacteria,1PU6K@1224|Proteobacteria,42VJG@68525|delta/epsilon subdivisions,2WRD6@28221|Deltaproteobacteria,2MP8Y@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Calcineurin-like phosphoesterase	-	-	-	ko:K07096	-	-	-	-	ko00000	-	-	-	Metallophos
REGS1_k127_7676677_1	56780.SYN_00534	1.22e-116	387.0	COG1408@1|root,COG1408@2|Bacteria,1MUH5@1224|Proteobacteria,42N75@68525|delta/epsilon subdivisions,2WKJY@28221|Deltaproteobacteria,2MQC9@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Calcineurin-like phosphoesterase	-	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos
REGS1_k127_7676677_4	335543.Sfum_1140	5.379e-83	280.0	COG0346@1|root,COG0346@2|Bacteria,1PM7Y@1224|Proteobacteria,42RD3@68525|delta/epsilon subdivisions,2WNY7@28221|Deltaproteobacteria,2MRMT@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
REGS1_k127_7676677_2	1123376.AUIU01000012_gene1346	1.383e-96	331.0	COG1519@1|root,COG1519@2|Bacteria,3J0J7@40117|Nitrospirae	40117|Nitrospirae	M	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase)	-	-	2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15	ko:K02527	ko00540,ko01100,map00540,map01100	M00060,M00080	R04658,R05074,R09763	RC00009,RC00077,RC00247	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT30	-	Glycos_transf_N
REGS1_k127_7676677_3	56780.SYN_01565	2.539e-85	297.0	COG0763@1|root,COG0763@2|Bacteria,1MVBI@1224|Proteobacteria,42P35@68525|delta/epsilon subdivisions,2WJFA@28221|Deltaproteobacteria,2MQCW@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxB	GO:0003674,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0019637,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.4.1.182	ko:K00748	ko00540,ko01100,map00540,map01100	M00060	R04606	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT19	-	LpxB
REGS1_k127_7676677_6	289376.THEYE_A0828	1.502e-27	114.0	COG0399@1|root,COG0399@2|Bacteria,3J09X@40117|Nitrospirae	40117|Nitrospirae	E	Belongs to the DegT DnrJ EryC1 family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
REGS1_k127_7683587_4	1210884.HG799466_gene12623	5.877e-77	269.0	COG0615@1|root,COG2870@1|root,COG0615@2|Bacteria,COG2870@2|Bacteria,2J3F5@203682|Planctomycetes	203682|Planctomycetes	IM	Cytidylyltransferase-like	-	-	-	-	-	-	-	-	-	-	-	-	CTP_transf_like,PfkB
REGS1_k127_7683587_5	402777.KB235904_gene3423	1.217e-55	200.0	COG0279@1|root,COG0279@2|Bacteria,1G1I9@1117|Cyanobacteria,1HDBA@1150|Oscillatoriales	1117|Cyanobacteria	G	SIS domain	gmhA	-	5.3.1.28	ko:K03271	ko00540,ko01100,map00540,map01100	M00064	R05645,R09768,R09769	RC00434	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Glyco_transf_4,Glycos_transf_1,SIS_2
REGS1_k127_7683587_1	1121447.JONL01000002_gene1980	5.359e-138	447.0	COG0535@1|root,COG0535@2|Bacteria,1PHAQ@1224|Proteobacteria,42Q23@68525|delta/epsilon subdivisions,2WWQD@28221|Deltaproteobacteria,2MA31@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM,SPASM
REGS1_k127_7683587_3	1291050.JAGE01000001_gene1614	3.952e-107	357.0	COG1071@1|root,COG1071@2|Bacteria,1TQDG@1239|Firmicutes,249HX@186801|Clostridia	186801|Clostridia	C	dehydrogenase, E1 component	-	-	1.2.4.1	ko:K00161,ko:K21416	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
REGS1_k127_7683587_2	1291050.JAGE01000001_gene1613	3.679e-125	409.0	COG0022@1|root,COG0022@2|Bacteria,1TP3J@1239|Firmicutes,249UD@186801|Clostridia	186801|Clostridia	C	COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit	-	-	1.2.4.1	ko:K00162,ko:K21417	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
REGS1_k127_7683587_8	1382356.JQMP01000004_gene418	2.861e-22	106.0	COG0463@1|root,COG0463@2|Bacteria,2G6TA@200795|Chloroflexi,27XT0@189775|Thermomicrobia	189775|Thermomicrobia	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
REGS1_k127_7683587_0	1144319.PMI16_04709	6.973e-146	471.0	COG0535@1|root,COG0535@2|Bacteria,1PHAQ@1224|Proteobacteria,2WEZX@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Iron-sulfur cluster-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM,SPASM
REGS1_k127_7683587_7	1380394.JADL01000001_gene2719	3.516e-36	150.0	COG2227@1|root,COG2227@2|Bacteria,1RI5H@1224|Proteobacteria,2U966@28211|Alphaproteobacteria,2JUN7@204441|Rhodospirillales	204441|Rhodospirillales	H	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
REGS1_k127_7683587_6	1131266.ARWQ01000013_gene69	2.597e-53	198.0	COG1032@1|root,arCOG01356@2157|Archaea	2157|Archaea	C	SMART Elongator protein 3 MiaB NifB	-	-	1.21.98.3	ko:K04034	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R06268,R06269,R06270	RC00741,RC01491,RC01492	ko00000,ko00001,ko01000	-	-	-	B12-binding,Radical_SAM
REGS1_k127_768691_1	269799.Gmet_2473	6.469e-131	427.0	COG1088@1|root,COG1088@2|Bacteria,1MU5E@1224|Proteobacteria,42MFN@68525|delta/epsilon subdivisions,2WIJE@28221|Deltaproteobacteria,43SUT@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily	rmlB	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
REGS1_k127_768691_3	316067.Geob_3480	4.838e-53	190.0	COG1898@1|root,COG1898@2|Bacteria,1RGRQ@1224|Proteobacteria,42RZA@68525|delta/epsilon subdivisions,2WNBP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	dTDP-4-dehydrorhamnose 3,5-epimerase	-	-	5.1.3.13	ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R06514	RC01531	ko00000,ko00001,ko00002,ko01000	-	-	-	dTDP_sugar_isom
REGS1_k127_768691_2	370438.PTH_1078	2.955e-130	424.0	COG1209@1|root,COG1209@2|Bacteria,1V301@1239|Firmicutes,247XE@186801|Clostridia,25ZY9@186807|Peptococcaceae	186801|Clostridia	M	PFAM Nucleotidyl transferase	-	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
REGS1_k127_768691_0	289376.THEYE_A0554	5.231e-157	500.0	COG0480@1|root,COG0480@2|Bacteria,3J0WU@40117|Nitrospirae	40117|Nitrospirae	J	Elongation factor G, domain IV	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
REGS1_k127_7691917_0	3659.XP_004135261.1	3.794e-236	764.0	COG0574@1|root,2QQ6R@2759|Eukaryota,37KSG@33090|Viridiplantae,3GDUC@35493|Streptophyta,4JEYT@91835|fabids	35493|Streptophyta	G	Alpha-glucan water dikinase	-	GO:0000272,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005975,GO:0005976,GO:0005982,GO:0005983,GO:0006073,GO:0006793,GO:0006796,GO:0006950,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009251,GO:0009266,GO:0009409,GO:0009507,GO:0009526,GO:0009532,GO:0009536,GO:0009570,GO:0009605,GO:0009607,GO:0009608,GO:0009610,GO:0009620,GO:0009628,GO:0009631,GO:0009941,GO:0009987,GO:0016052,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016781,GO:0031967,GO:0031975,GO:0043170,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0050521,GO:0050896,GO:0051704,GO:0051707,GO:0071704,GO:1901575	2.7.9.4	ko:K08244	-	-	-	-	ko00000,ko01000	-	-	-	PPDK_N
REGS1_k127_7691917_2	330214.NIDE1479	4.41e-32	135.0	COG3000@1|root,COG3000@2|Bacteria	330214.NIDE1479|-	I	iron ion binding	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_7691917_1	247490.KSU1_C0040	1.663e-73	254.0	COG0229@1|root,COG0229@2|Bacteria,2IZVK@203682|Planctomycetes	203682|Planctomycetes	O	peptide-methionine (R)-S-oxide reductase	msrB	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
REGS1_k127_7697794_0	247490.KSU1_C1578	1.643e-202	639.0	COG3829@1|root,COG3829@2|Bacteria,2J2D8@203682|Planctomycetes	203682|Planctomycetes	KT	Sigma-54 interaction domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,PAS_10,PAS_4,Response_reg,Sigma54_activat
REGS1_k127_7741564_8	589865.DaAHT2_0103	1.274e-21	106.0	COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,42TE0@68525|delta/epsilon subdivisions,2WPEP@28221|Deltaproteobacteria,2MKDG@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
REGS1_k127_7741564_3	1121403.AUCV01000001_gene869	1.158e-127	413.0	COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,42MKP@68525|delta/epsilon subdivisions,2WJU9@28221|Deltaproteobacteria,2MJJN@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	livH	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
REGS1_k127_7741564_2	1167006.UWK_00092	1.894e-145	471.0	COG0683@1|root,COG0683@2|Bacteria,1MXR4@1224|Proteobacteria,42MXX@68525|delta/epsilon subdivisions,2WKJM@28221|Deltaproteobacteria,2MHQS@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
REGS1_k127_7741564_7	880072.Desac_2016	8.545e-60	210.0	COG4747@1|root,COG4747@2|Bacteria,1RDCG@1224|Proteobacteria,42RTD@68525|delta/epsilon subdivisions,2WNC2@28221|Deltaproteobacteria,2MRPV@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	ACT domain	-	-	-	-	-	-	-	-	-	-	-	-	ACT
REGS1_k127_7741564_1	589865.DaAHT2_0107	7.303e-210	659.0	COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,42NKD@68525|delta/epsilon subdivisions,2WIWV@28221|Deltaproteobacteria,2MIVW@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	paaK-2	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_1825	AMP-binding,AMP-binding_C_2
REGS1_k127_7741564_6	177439.DP1265	6.984e-70	244.0	COG1014@1|root,COG1014@2|Bacteria,1RH9B@1224|Proteobacteria,42SK4@68525|delta/epsilon subdivisions,2WPI8@28221|Deltaproteobacteria,2MNKA@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	iorB-1	-	1.2.7.8	ko:K00180	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR
REGS1_k127_7741564_0	589865.DaAHT2_0109	2.147e-268	838.0	COG4231@1|root,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,42N44@68525|delta/epsilon subdivisions,2WIX6@28221|Deltaproteobacteria,2MMVZ@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	iorA-1	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,Fer4_7,POR_N,TPP_enzyme_C
REGS1_k127_7741564_5	589865.DaAHT2_0096	7.596e-94	314.0	COG2159@1|root,COG2159@2|Bacteria,1RDRH@1224|Proteobacteria,42T80@68525|delta/epsilon subdivisions,2WPGY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
REGS1_k127_7741564_4	1123376.AUIU01000002_gene1667	2.437e-127	422.0	28KQH@1|root,2ZA8A@2|Bacteria	2|Bacteria	S	Alginate export	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_exp
REGS1_k127_7741564_9	269799.Gmet_0139	1.248e-12	80.0	COG5295@1|root,COG5295@2|Bacteria	2|Bacteria	UW	Hep Hag repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	Pectinesterase,YadA_stalk
REGS1_k127_7741564_10	649747.HMPREF0083_03356	4.533e-08	55.0	COG1236@1|root,COG1236@2|Bacteria,1TQBH@1239|Firmicutes,4HEYA@91061|Bacilli,275V2@186822|Paenibacillaceae	91061|Bacilli	J	Metallo-beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Beta-Casp,Lactamase_B,Lactamase_B_6,RMMBL
REGS1_k127_7765664_3	1333523.L593_07565	5.321e-35	136.0	COG2314@1|root,arCOG03293@2157|Archaea,2Y83Z@28890|Euryarchaeota,2414J@183963|Halobacteria	183963|Halobacteria	S	TM2 domain	-	-	-	-	-	-	-	-	-	-	-	-	TM2,zf-ribbon_3
REGS1_k127_7765664_0	290397.Adeh_0674	2.572e-167	569.0	COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,42MN9@68525|delta/epsilon subdivisions,2WJZF@28221|Deltaproteobacteria,2YU45@29|Myxococcales	28221|Deltaproteobacteria	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
REGS1_k127_7765664_1	96561.Dole_0002	1.446e-155	503.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,42M0V@68525|delta/epsilon subdivisions,2WIQ1@28221|Deltaproteobacteria,2MI3F@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM FAD linked oxidase domain protein	larD	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_3245	FAD-oxidase_C,FAD_binding_4
REGS1_k127_7765664_2	944479.JQLX01000012_gene1156	2.037e-81	286.0	COG2801@1|root,COG2801@2|Bacteria,1MWVQ@1224|Proteobacteria,439VX@68525|delta/epsilon subdivisions,2X5A1@28221|Deltaproteobacteria,2M7IX@213113|Desulfurellales	28221|Deltaproteobacteria	L	Winged helix-turn helix	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_7765664_4	1232410.KI421424_gene1587	2.517e-31	130.0	COG0526@1|root,COG0526@2|Bacteria,1N726@1224|Proteobacteria,42U61@68525|delta/epsilon subdivisions,2WQRF@28221|Deltaproteobacteria,43VC5@69541|Desulfuromonadales	28221|Deltaproteobacteria	CO	Glutathione peroxidase	resA	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
REGS1_k127_7772395_0	1499967.BAYZ01000068_gene1962	1.93e-100	338.0	COG4972@1|root,COG4972@2|Bacteria,2NPF6@2323|unclassified Bacteria	2|Bacteria	NU	Type IV pilus assembly protein PilM;	pilM	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilM_2
REGS1_k127_7772395_5	1242864.D187_006598	1.802e-05	53.0	COG3166@1|root,COG3166@2|Bacteria,1Q1I0@1224|Proteobacteria,42W65@68525|delta/epsilon subdivisions,2WS79@28221|Deltaproteobacteria	28221|Deltaproteobacteria	NU	PFAM Fimbrial assembly family protein	pilN	-	-	ko:K02663	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilN
REGS1_k127_7772395_2	289376.THEYE_A0420	2.111e-22	105.0	COG3167@1|root,COG3167@2|Bacteria,3J1BH@40117|Nitrospirae	40117|Nitrospirae	NU	Pilus assembly protein, PilO	-	-	-	ko:K02664	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilO
REGS1_k127_7772395_3	525897.Dbac_1981	1.591e-11	71.0	COG3168@1|root,COG3168@2|Bacteria,1PSEK@1224|Proteobacteria,4374W@68525|delta/epsilon subdivisions,2X1MP@28221|Deltaproteobacteria,2MFBC@213115|Desulfovibrionales	28221|Deltaproteobacteria	NU	Pilus assembly protein, PilP	-	-	-	ko:K02665	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilP
REGS1_k127_7772395_1	1125863.JAFN01000001_gene2283	9.342e-83	303.0	COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,42MKN@68525|delta/epsilon subdivisions,2WJV6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	U	Type II and III secretion system protein	pilQ	-	-	ko:K02666	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	AMIN,STN,Secretin,Secretin_N
REGS1_k127_7772395_4	349966.DJ58_3162	2.334e-08	66.0	COG1388@1|root,COG4932@1|root,COG1388@2|Bacteria,COG4932@2|Bacteria,1MX9S@1224|Proteobacteria,1RPK7@1236|Gammaproteobacteria,41E3X@629|Yersinia	1236|Gammaproteobacteria	M	Inverse autotransporter, beta-domain	eaeH	GO:0005575,GO:0005623,GO:0007155,GO:0008150,GO:0009279,GO:0009405,GO:0009987,GO:0016020,GO:0019867,GO:0022610,GO:0030260,GO:0030312,GO:0030313,GO:0031589,GO:0031975,GO:0042710,GO:0043708,GO:0044403,GO:0044409,GO:0044419,GO:0044462,GO:0044464,GO:0044764,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0071944,GO:0090605	-	ko:K13735	ko05100,map05100	-	-	-	ko00000,ko00001	-	-	-	Big_1,Big_2,IAT_beta,Invasin_D3,LysM
REGS1_k127_7772839_1	338963.Pcar_1177	9.454e-41	155.0	COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,42T0Q@68525|delta/epsilon subdivisions,2WUA0@28221|Deltaproteobacteria,43SZX@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	diguanylate cyclase	-	-	2.7.7.65	ko:K02488	ko02020,ko04112,map02020,map04112	M00511	R08057	-	ko00000,ko00001,ko00002,ko01000,ko02022	-	-	-	GAF_2,GGDEF,Response_reg
REGS1_k127_7772839_0	289376.THEYE_A1552	1.183e-161	527.0	COG0517@1|root,COG0617@1|root,COG0618@1|root,COG0517@2|Bacteria,COG0617@2|Bacteria,COG0618@2|Bacteria,3J0NX@40117|Nitrospirae	40117|Nitrospirae	J	Probable RNA and SrmB- binding site of polymerase A	-	-	2.7.7.72	ko:K00974	ko03013,map03013	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	CBS,DHH,DHHA1,PolyA_pol,PolyA_pol_RNAbd
REGS1_k127_7804931_0	269799.Gmet_1386	4.134e-183	595.0	COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,42NGS@68525|delta/epsilon subdivisions,2WIWF@28221|Deltaproteobacteria,43TQ3@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	OB_RNB,RNB,S1
REGS1_k127_7804931_1	517417.Cpar_1205	4.165e-108	356.0	COG1512@1|root,COG1512@2|Bacteria,1FENY@1090|Chlorobi	1090|Chlorobi	S	TPM domain	-	-	-	ko:K06872	-	-	-	-	ko00000	-	-	-	TPM_phosphatase
REGS1_k127_781626_0	926692.AZYG01000034_gene2406	3.722e-111	365.0	COG0115@1|root,COG0115@2|Bacteria,1TPY2@1239|Firmicutes,25CC3@186801|Clostridia,3WAHQ@53433|Halanaerobiales	186801|Clostridia	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
REGS1_k127_781626_1	880073.Calab_3686	4.194e-40	159.0	COG1378@1|root,COG1378@2|Bacteria,2NRFE@2323|unclassified Bacteria	2|Bacteria	K	Archaeal transcriptional regulator TrmB	yrhO1	-	-	-	-	-	-	-	-	-	-	-	Regulator_TrmB,TrmB
REGS1_k127_781626_2	247490.KSU1_B0518	2.935e-36	144.0	COG4275@1|root,COG4275@2|Bacteria	2|Bacteria	S	Chromate resistance exported protein	chrB	-	-	-	-	-	-	-	-	-	-	-	Chrome_Resist
REGS1_k127_7819266_3	56107.Cylst_5512	5.628e-31	128.0	COG1656@1|root,COG1656@2|Bacteria,1G344@1117|Cyanobacteria,1HQGH@1161|Nostocales	1117|Cyanobacteria	S	Mut7-C ubiquitin	-	-	-	ko:K09122	-	-	-	-	ko00000	-	-	-	Mut7-C,Ub-Mut7C
REGS1_k127_7819266_2	1379281.AVAG01000023_gene1915	1.033e-86	290.0	COG1592@1|root,COG1592@2|Bacteria,1R9WG@1224|Proteobacteria,42N9V@68525|delta/epsilon subdivisions,2WJWQ@28221|Deltaproteobacteria,2M9B4@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM Rubrerythrin	rbr	GO:0003674,GO:0005488,GO:0005506,GO:0043167,GO:0043169,GO:0046872,GO:0046914	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
REGS1_k127_7819266_1	525897.Dbac_3408	1.716e-121	398.0	COG0492@1|root,COG0492@2|Bacteria,1MV15@1224|Proteobacteria,42MHR@68525|delta/epsilon subdivisions,2WIY8@28221|Deltaproteobacteria,2M86G@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	trxB-2	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
REGS1_k127_7819266_4	1125863.JAFN01000001_gene284	5.661e-10	71.0	COG1512@1|root,COG1512@2|Bacteria,1PB41@1224|Proteobacteria,42R0Q@68525|delta/epsilon subdivisions,2WN87@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Beta-propeller domains of methanol dehydrogenase type	-	-	-	ko:K06872	-	-	-	-	ko00000	-	-	-	TPM_phosphatase
REGS1_k127_7819266_0	1123376.AUIU01000012_gene1617	0.0	1212.0	COG0086@1|root,COG0086@2|Bacteria,3J0BT@40117|Nitrospirae	40117|Nitrospirae	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
REGS1_k127_7827006_1	289376.THEYE_A0092	1.391e-99	332.0	COG1044@1|root,COG1044@2|Bacteria,3J0GQ@40117|Nitrospirae	40117|Nitrospirae	M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxD	-	2.3.1.191	ko:K02536	ko00540,ko01100,map00540,map01100	M00060	R04550	RC00039,RC00166	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hexapep,LpxD
REGS1_k127_7827006_3	1123376.AUIU01000012_gene1503	2.991e-58	205.0	COG0764@1|root,COG0764@2|Bacteria,3J0NG@40117|Nitrospirae	40117|Nitrospirae	I	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs	fabZ	-	4.2.1.59	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
REGS1_k127_7827006_0	289376.THEYE_A0090	2.911e-112	367.0	COG1043@1|root,COG1043@2|Bacteria,3J0G6@40117|Nitrospirae	40117|Nitrospirae	M	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxA	-	2.3.1.129	ko:K00677	ko00540,ko01100,ko01503,map00540,map01100,map01503	M00060	R04567	RC00039,RC00055	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Acetyltransf_11,Hexapep
REGS1_k127_7827006_2	289376.THEYE_A0089	7.448e-71	248.0	COG3494@1|root,COG3494@2|Bacteria,3J0KP@40117|Nitrospirae	40117|Nitrospirae	S	Protein of unknown function (DUF1009)	-	-	-	ko:K09949	-	-	-	-	ko00000	-	-	-	DUF1009
REGS1_k127_7853472_1	330214.NIDE1676	2.253e-37	143.0	COG1066@1|root,COG1066@2|Bacteria,3J0BP@40117|Nitrospirae	40117|Nitrospirae	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	ATPase,ChlI,Lon_C
REGS1_k127_7853472_0	1242864.D187_006587	4.926e-88	297.0	COG3267@1|root,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,42MM0@68525|delta/epsilon subdivisions,2WKXZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	U	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22
REGS1_k127_7863582_5	1121324.CLIT_13c01630	3.53e-07	61.0	COG4942@1|root,COG4942@2|Bacteria,1TQ5I@1239|Firmicutes,248ZG@186801|Clostridia,25SSP@186804|Peptostreptococcaceae	186801|Clostridia	D	Peptidase family M23	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
REGS1_k127_7863582_2	349161.Dred_3072	2.192e-31	135.0	COG2177@1|root,COG2177@2|Bacteria,1TPND@1239|Firmicutes,24AA6@186801|Clostridia,2611R@186807|Peptococcaceae	186801|Clostridia	D	Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation	ftsX	-	-	ko:K09811	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	FtsX
REGS1_k127_7863582_1	1123376.AUIU01000015_gene454	4.499e-69	241.0	COG2884@1|root,COG2884@2|Bacteria,3J139@40117|Nitrospirae	40117|Nitrospirae	D	ABC transporter	ftsE	-	-	ko:K09812	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	ABC_tran
REGS1_k127_7863582_4	269799.Gmet_0550	4.273e-25	109.0	2ET40@1|root,33KN7@2|Bacteria,1R3K5@1224|Proteobacteria,43DKI@68525|delta/epsilon subdivisions,2X8RQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_7863582_0	316067.Geob_2508	4.252e-97	327.0	COG0709@1|root,COG0709@2|Bacteria,1MWFG@1224|Proteobacteria,42MC3@68525|delta/epsilon subdivisions,2WK3M@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Synthesizes selenophosphate from selenide and ATP	selD	-	2.7.9.3	ko:K01008	ko00450,ko01100,map00450,map01100	-	R03595	RC00002,RC02878	ko00000,ko00001,ko01000,ko03016	-	-	-	AIRS,AIRS_C
REGS1_k127_7863582_3	644966.Tmar_0250	4.471e-26	110.0	COG0640@1|root,COG0640@2|Bacteria,1VPBF@1239|Firmicutes,24VJN@186801|Clostridia	186801|Clostridia	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5
REGS1_k127_7870853_10	945713.IALB_1398	5.044e-12	69.0	COG0109@1|root,COG0109@2|Bacteria	2|Bacteria	O	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	ctaB	GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008495,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
REGS1_k127_7870853_11	926567.TheveDRAFT_0086	4.592e-11	71.0	COG0741@1|root,COG0741@2|Bacteria,3TB7C@508458|Synergistetes	508458|Synergistetes	M	PFAM Lytic transglycosylase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	SLT
REGS1_k127_7870853_7	439235.Dalk_1036	5.509e-27	119.0	COG2840@1|root,COG2840@2|Bacteria,1RH34@1224|Proteobacteria,42TQG@68525|delta/epsilon subdivisions,2WQG8@28221|Deltaproteobacteria,2MNQJ@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM Smr protein MutS2	-	-	-	-	-	-	-	-	-	-	-	-	Smr
REGS1_k127_7870853_9	1121346.KB899813_gene2194	9.571e-19	98.0	COG4244@1|root,COG4244@2|Bacteria,1UHFB@1239|Firmicutes,4HCQT@91061|Bacilli,26UEU@186822|Paenibacillaceae	91061|Bacilli	S	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_7870853_0	335543.Sfum_2105	2.193e-174	555.0	COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,42N8U@68525|delta/epsilon subdivisions,2WJAN@28221|Deltaproteobacteria,2MRE9@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Belongs to the citrate synthase family	citZ	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt,HTH_17
REGS1_k127_7870853_1	909663.KI867150_gene1374	4.482e-126	411.0	COG0039@1|root,COG0039@2|Bacteria,1MV57@1224|Proteobacteria,42KZJ@68525|delta/epsilon subdivisions,2WJ4U@28221|Deltaproteobacteria,2MQPY@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	-	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
REGS1_k127_7870853_2	1232410.KI421412_gene435	9.18e-90	301.0	COG0564@1|root,COG0564@2|Bacteria,1MVJ5@1224|Proteobacteria,42PI3@68525|delta/epsilon subdivisions,2WJN3@28221|Deltaproteobacteria,43TSZ@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	RNA pseudouridylate synthase	-	-	5.4.99.23,5.4.99.28,5.4.99.29	ko:K06177,ko:K06180	-	-	-	-	ko00000,ko01000,ko03009,ko03016	-	-	-	PseudoU_synth_2
REGS1_k127_7870853_5	237368.SCABRO_00505	4.424e-50	184.0	COG2996@1|root,COG2996@2|Bacteria,2J1Y7@203682|Planctomycetes	203682|Planctomycetes	S	S1 domain	-	-	-	ko:K00243	-	-	-	-	ko00000	-	-	-	S1_2
REGS1_k127_7870853_3	289376.THEYE_A1674	5.817e-75	259.0	COG0565@1|root,COG0565@2|Bacteria	2|Bacteria	J	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA	trmJ	-	2.1.1.200,3.5.1.19,6.1.1.16	ko:K01883,ko:K02533,ko:K08281,ko:K15396	ko00760,ko00970,ko01100,map00760,map00970,map01100	M00359,M00360	R01268,R03650	RC00055,RC00100,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	SpoU_methylase
REGS1_k127_7870853_4	1116472.MGMO_97c00020	9.774e-54	191.0	COG0662@1|root,COG0662@2|Bacteria,1N00P@1224|Proteobacteria,1S759@1236|Gammaproteobacteria,1XFIZ@135618|Methylococcales	135618|Methylococcales	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
REGS1_k127_7870853_8	105559.Nwat_1924	9.9e-23	99.0	COG1724@1|root,COG1724@2|Bacteria,1NHPS@1224|Proteobacteria,1SGDT@1236|Gammaproteobacteria,1WZRG@135613|Chromatiales	135613|Chromatiales	N	HicA toxin of bacterial toxin-antitoxin,	-	-	-	ko:K07339	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HicA_toxin
REGS1_k127_7870853_6	472759.Nhal_0804	1.03e-28	116.0	COG1598@1|root,COG1598@2|Bacteria,1NF1P@1224|Proteobacteria,1SDMW@1236|Gammaproteobacteria,1WZBB@135613|Chromatiales	135613|Chromatiales	S	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_791397_1	243231.GSU0230	4.215e-72	247.0	COG2805@1|root,COG2805@2|Bacteria,1R6FY@1224|Proteobacteria,42MPJ@68525|delta/epsilon subdivisions,2WK57@28221|Deltaproteobacteria,43SCV@69541|Desulfuromonadales	28221|Deltaproteobacteria	NU	Type II/IV secretion system protein	pilT-2	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
REGS1_k127_791397_0	269799.Gmet_0261	2.859e-149	492.0	COG1846@1|root,COG1846@2|Bacteria,1NRG9@1224|Proteobacteria,42YC6@68525|delta/epsilon subdivisions,2WTKJ@28221|Deltaproteobacteria,43TP5@69541|Desulfuromonadales	28221|Deltaproteobacteria	K	Domain of unknown function (DUF4388)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4388
REGS1_k127_7925819_2	1123288.SOV_1c07960	8.411e-106	353.0	COG1894@1|root,COG1894@2|Bacteria,1TQB0@1239|Firmicutes,4H266@909932|Negativicutes	909932|Negativicutes	C	NADH dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
REGS1_k127_7925819_3	555779.Dthio_PD3237	1.426e-52	189.0	COG1905@1|root,COG1905@2|Bacteria,1MWS2@1224|Proteobacteria,42SED@68525|delta/epsilon subdivisions,2WPP9@28221|Deltaproteobacteria,2M7XW@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit	nuoE-2	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
REGS1_k127_7925819_0	555779.Dthio_PD3238	5.537e-320	990.0	COG0369@1|root,COG1151@2|Bacteria,1NYH2@1224|Proteobacteria,42NE1@68525|delta/epsilon subdivisions,2WIVX@28221|Deltaproteobacteria,2M9QY@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	TIGRFAM Carbon-monoxide dehydrogenase, catalytic subunit	-	-	1.2.7.4	ko:K00198	ko00633,ko00680,ko00720,ko01120,ko01200,map00633,map00680,map00720,map01120,map01200	M00377	R07157,R08034	RC00250,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Prismane
REGS1_k127_7925819_1	555779.Dthio_PD3239	1.397e-269	848.0	COG1614@1|root,COG1614@2|Bacteria,1MVI5@1224|Proteobacteria,42N9A@68525|delta/epsilon subdivisions,2WK4H@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM CO dehydrogenase acetyl-CoA synthase complex beta subunit	-	-	2.3.1.169	ko:K14138	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00377	R08433,R10243	RC00004,RC00113,RC01144,RC02963,RC02964,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhC
REGS1_k127_7927694_1	289376.THEYE_A0623	5.227e-105	366.0	COG0457@1|root,COG0741@1|root,COG1729@1|root,COG0457@2|Bacteria,COG0741@2|Bacteria,COG1729@2|Bacteria,3J0VD@40117|Nitrospirae	40117|Nitrospirae	M	Transglycosylase SLT domain	-	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	SLT,TPR_3,TPR_6
REGS1_k127_7927694_0	1232410.KI421412_gene445	4.244e-130	434.0	2EWA0@1|root,33PNR@2|Bacteria,1NSPR@1224|Proteobacteria,42YN1@68525|delta/epsilon subdivisions,2WTJI@28221|Deltaproteobacteria,43U3D@69541|Desulfuromonadales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_7928406_2	1121403.AUCV01000062_gene3688	1.44e-104	342.0	COG0519@1|root,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,42M0I@68525|delta/epsilon subdivisions,2WJ6D@28221|Deltaproteobacteria,2MJ7G@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Catalyzes the synthesis of GMP from XMP	guaA	GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase,tRNA_Me_trans
REGS1_k127_7928406_4	316067.Geob_2628	1.254e-89	304.0	COG0142@1|root,COG0142@2|Bacteria,1MWNG@1224|Proteobacteria,42NPN@68525|delta/epsilon subdivisions,2WIY4@28221|Deltaproteobacteria,43U3I@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Polyprenyl synthetase	ispA	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K00795,ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00366	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
REGS1_k127_7928406_0	269799.Gmet_1934	1.683e-233	741.0	COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,42M35@68525|delta/epsilon subdivisions,2WIX5@28221|Deltaproteobacteria,43UFS@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
REGS1_k127_7928406_9	290512.Paes_1915	1.279e-33	144.0	COG1572@1|root,COG1572@2|Bacteria,1FEDB@1090|Chlorobi	2|Bacteria	S	cell adhesion involved in biofilm formation	-	-	-	-	-	-	-	-	-	-	-	-	CARDB
REGS1_k127_7928406_3	373903.Hore_08350	2.26e-98	329.0	COG0705@1|root,COG0705@2|Bacteria,1TSBP@1239|Firmicutes,249D8@186801|Clostridia	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
REGS1_k127_7928406_6	269799.Gmet_1222	6.102e-86	290.0	COG1189@1|root,COG1189@2|Bacteria,1MWP5@1224|Proteobacteria,42R2J@68525|delta/epsilon subdivisions,2WIJ6@28221|Deltaproteobacteria,43S7C@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	ribosomal RNA methyltransferase RrmJ FtsJ	tlyA	-	2.1.1.226,2.1.1.227	ko:K06442	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ,S4
REGS1_k127_7928406_10	1121920.AUAU01000023_gene2406	1.432e-25	114.0	2DMMW@1|root,32SIJ@2|Bacteria,3Y8YH@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_7928406_5	483219.LILAB_16735	3.388e-86	310.0	COG0840@1|root,COG3850@1|root,COG0840@2|Bacteria,COG3850@2|Bacteria,1RG2B@1224|Proteobacteria,42RYX@68525|delta/epsilon subdivisions,2WNHC@28221|Deltaproteobacteria,2YU4H@29|Myxococcales	28221|Deltaproteobacteria	NT	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer).	rppA	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal
REGS1_k127_7928406_7	443143.GM18_3087	2.97e-56	209.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,42MU0@68525|delta/epsilon subdivisions,2WJW5@28221|Deltaproteobacteria,43UU9@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
REGS1_k127_7928406_8	316067.Geob_2911	4.001e-51	205.0	2E1I6@1|root,32WW2@2|Bacteria,1NTI4@1224|Proteobacteria,42YDB@68525|delta/epsilon subdivisions,2WTNY@28221|Deltaproteobacteria,43TFS@69541|Desulfuromonadales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	MtrB_PioB
REGS1_k127_7928406_1	316067.Geob_2912	7.047e-119	390.0	COG3005@1|root,COG3005@2|Bacteria,1RHMA@1224|Proteobacteria,42Z4M@68525|delta/epsilon subdivisions,2WU8J@28221|Deltaproteobacteria,43U75@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	cytochrome C	omcI	-	-	-	-	-	-	-	-	-	-	-	Paired_CXXCH_1
REGS1_k127_7928406_11	316067.Geob_1031	4.581e-22	104.0	COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,42N5S@68525|delta/epsilon subdivisions,2WIUS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Adenylyl cyclase class-3 4 guanylyl cyclase	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc
REGS1_k127_7934507_1	1123376.AUIU01000014_gene534	1.377e-66	233.0	COG0774@1|root,COG0774@2|Bacteria,3J0JG@40117|Nitrospirae	40117|Nitrospirae	M	Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis	lpxC	-	3.5.1.108	ko:K02535	ko00540,ko01100,map00540,map01100	M00060	R04587	RC00166,RC00300	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxC
REGS1_k127_7934507_0	269799.Gmet_2720	5.363e-170	545.0	COG0312@1|root,COG0312@2|Bacteria,1MUSK@1224|Proteobacteria,42QCV@68525|delta/epsilon subdivisions,2WJP8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Peptidase U62 modulator of DNA gyrase	tldD	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
REGS1_k127_797584_4	42099.EPrPV00000014929	9.642e-09	68.0	COG0484@1|root,COG1226@1|root,KOG0550@2759|Eukaryota,KOG2508@2759|Eukaryota,1MGI7@121069|Pythiales	121069|Pythiales	O	DnaJ subfamily C protein. Source PGD	-	-	-	-	-	-	-	-	-	-	-	-	DnaJ,TPR_1,TPR_16,TPR_2
REGS1_k127_797584_2	316067.Geob_2352	3.745e-68	236.0	COG0693@1|root,COG0693@2|Bacteria,1N7T2@1224|Proteobacteria,42RGX@68525|delta/epsilon subdivisions,2WNKJ@28221|Deltaproteobacteria,43SR5@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	DJ-1/PfpI family	-	-	3.5.1.124	ko:K03152,ko:K05520,ko:K05687	ko05012,map05012	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04147	-	-	-	DJ-1_PfpI
REGS1_k127_797584_0	909663.KI867150_gene54	3.145e-237	750.0	COG1331@1|root,COG1331@2|Bacteria,1MUUT@1224|Proteobacteria,42MP3@68525|delta/epsilon subdivisions,2WJ7Y@28221|Deltaproteobacteria,2MQ5N@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	Protein of unknown function, DUF255	yyaL	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	GlcNAc_2-epim,Thioredox_DsbH
REGS1_k127_797584_1	909663.KI867150_gene1365	7.848e-139	449.0	COG0535@1|root,COG0535@2|Bacteria,1MUQP@1224|Proteobacteria,42M55@68525|delta/epsilon subdivisions,2WIKM@28221|Deltaproteobacteria,2MQ84@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM,SPASM
REGS1_k127_797584_3	909663.KI867151_gene3123	1.995e-38	152.0	COG2020@1|root,COG2020@2|Bacteria	2|Bacteria	O	methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	ICMT,PEMT
REGS1_k127_7988539_0	933262.AXAM01000018_gene1014	4.239e-140	454.0	COG2006@1|root,COG2221@1|root,COG2006@2|Bacteria,COG2221@2|Bacteria,1RABP@1224|Proteobacteria,42QQA@68525|delta/epsilon subdivisions,2WMRX@28221|Deltaproteobacteria,2MK55@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF362,Fer4
REGS1_k127_7988539_2	1047013.AQSP01000033_gene1393	4.665e-28	116.0	COG0640@1|root,COG0640@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
REGS1_k127_7988539_1	1047013.AQSP01000033_gene1392	2.232e-37	145.0	2B0BZ@1|root,31SP3@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_7988539_3	1232410.KI421412_gene25	9.652e-20	93.0	COG1729@1|root,COG1729@2|Bacteria,1N0AW@1224|Proteobacteria,42TGH@68525|delta/epsilon subdivisions,2WQ33@28221|Deltaproteobacteria,43VCJ@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Thioredoxin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	TPR_6,Thioredoxin_2,Thioredoxin_7
REGS1_k127_7988962_0	289376.THEYE_A1196	1.488e-226	711.0	COG0034@1|root,COG0034@2|Bacteria,3J0C5@40117|Nitrospirae	40117|Nitrospirae	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_7,Pribosyltran
REGS1_k127_7988962_1	1449126.JQKL01000006_gene825	2.857e-128	419.0	COG0310@1|root,COG0310@2|Bacteria,1TPEN@1239|Firmicutes,248S9@186801|Clostridia	186801|Clostridia	P	PFAM cobalamin (vitamin B12) biosynthesis CbiM	cbiM2	-	-	ko:K02007	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiM,PDGLE
REGS1_k127_7988962_2	1232410.KI421428_gene1009	3.697e-79	272.0	COG0619@1|root,COG0619@2|Bacteria,1R2DN@1224|Proteobacteria,43B6A@68525|delta/epsilon subdivisions,2X6JT@28221|Deltaproteobacteria,43S05@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	Cobalt transport protein	nikQ	-	-	ko:K02008	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiQ
REGS1_k127_8022819_1	243231.GSU0034	2.79e-131	428.0	COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,42KZM@68525|delta/epsilon subdivisions,2WJGP@28221|Deltaproteobacteria,43U2H@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
REGS1_k127_8022819_3	289376.THEYE_A1657	9.373e-50	185.0	COG1385@1|root,COG1385@2|Bacteria,3J18K@40117|Nitrospirae	40117|Nitrospirae	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	-	-	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
REGS1_k127_8022819_0	1123376.AUIU01000012_gene1586	5.54e-139	454.0	COG1253@1|root,COG1253@2|Bacteria,3J0KN@40117|Nitrospirae	40117|Nitrospirae	S	Transporter associated domain	-	-	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
REGS1_k127_8022819_2	289376.THEYE_A0277	1.239e-107	354.0	COG0413@1|root,COG0413@2|Bacteria,3J0GX@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
REGS1_k127_8022819_5	43989.cce_1677	1.319e-09	68.0	COG5413@1|root,COG5413@2|Bacteria,1G3RC@1117|Cyanobacteria,3KGPW@43988|Cyanothece	1117|Cyanobacteria	S	Uncharacterized integral membrane protein (DUF2301)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2301
REGS1_k127_8022819_6	1122182.KB903836_gene5017	0.0009561	48.0	COG1413@1|root,COG1413@2|Bacteria,2IRUS@201174|Actinobacteria,4DF7W@85008|Micromonosporales	201174|Actinobacteria	C	HEAT repeat	-	-	-	-	-	-	-	-	-	-	-	-	HEAT,HEAT_2
REGS1_k127_8104039_1	237368.SCABRO_00950	2.116e-86	298.0	COG1565@1|root,COG1565@2|Bacteria,2J22U@203682|Planctomycetes	203682|Planctomycetes	S	Putative S-adenosyl-L-methionine-dependent methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_28
REGS1_k127_8104039_0	289376.THEYE_A1274	1.055e-90	305.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
REGS1_k127_8104039_2	1123376.AUIU01000012_gene1592	3.44e-23	102.0	COG2331@1|root,COG2331@2|Bacteria,3J0V8@40117|Nitrospirae	40117|Nitrospirae	S	Putative regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
REGS1_k127_8108704_0	909663.KI867150_gene2798	1.614e-217	689.0	COG1615@1|root,COG1615@2|Bacteria,1MZ5A@1224|Proteobacteria,42M4M@68525|delta/epsilon subdivisions,2WIPI@28221|Deltaproteobacteria,2MQB3@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Uncharacterised protein family (UPF0182)	-	-	-	ko:K09118	-	-	-	-	ko00000	-	-	-	UPF0182
REGS1_k127_8108704_1	1121403.AUCV01000001_gene908	6.603e-113	374.0	COG0042@1|root,COG0042@2|Bacteria,1MV5V@1224|Proteobacteria,42M3I@68525|delta/epsilon subdivisions,2WIXZ@28221|Deltaproteobacteria,2MI4J@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	-	-	-	-	-	-	-	-	-	-	-	-	Dus
REGS1_k127_815188_3	865861.AZSU01000002_gene2831	7.739e-09	66.0	COG0760@1|root,COG0760@2|Bacteria,1TX3R@1239|Firmicutes,24C7H@186801|Clostridia,36G5K@31979|Clostridiaceae	186801|Clostridia	M	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins	prsA	-	5.2.1.8	ko:K03769,ko:K07533	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_3
REGS1_k127_815188_2	247490.KSU1_A0071	2.004e-112	372.0	COG0309@1|root,COG0309@2|Bacteria,2IX50@203682|Planctomycetes	203682|Planctomycetes	O	AIR synthase related protein, C-terminal domain	-	-	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
REGS1_k127_815188_1	289376.THEYE_A1019	8.335e-147	473.0	COG0409@1|root,COG0409@2|Bacteria,3J0W7@40117|Nitrospirae	40117|Nitrospirae	O	Hydrogenase formation hypA family	hypD	-	-	ko:K04654	-	-	-	-	ko00000	-	-	-	HypD
REGS1_k127_815188_0	1123376.AUIU01000012_gene1341	1.025e-196	632.0	COG0068@1|root,COG0068@2|Bacteria,3J0WS@40117|Nitrospirae	40117|Nitrospirae	O	Telomere recombination	hypF	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
REGS1_k127_816358_6	1121403.AUCV01000026_gene2353	2.234e-23	105.0	COG0517@1|root,COG0517@2|Bacteria,1N0H3@1224|Proteobacteria,43CQG@68525|delta/epsilon subdivisions	1224|Proteobacteria	S	Domain in cystathionine beta-synthase and other proteins.	MA20_31615	-	-	-	-	-	-	-	-	-	-	-	CBS
REGS1_k127_816358_3	1123376.AUIU01000013_gene1898	4.201e-122	402.0	COG1150@1|root,COG2181@1|root,COG1150@2|Bacteria,COG2181@2|Bacteria	2|Bacteria	C	nitrate reductase activity	dld	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03390,ko:K16887,ko:K18930	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_17,Fer4_7,Fer4_8,Fer4_9,Nitrate_red_gam
REGS1_k127_816358_1	933262.AXAM01000009_gene1491	6.211e-304	949.0	COG1148@1|root,COG1908@1|root,COG1148@2|Bacteria,COG1908@2|Bacteria,1MWAG@1224|Proteobacteria,42NNE@68525|delta/epsilon subdivisions,2WJZX@28221|Deltaproteobacteria,2MI6X@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Methyl-viologen-reducing hydrogenase, delta subunit	qmoB	-	-	ko:K16886	-	-	-	-	ko00000	-	-	-	Fer4,Fer4_9,FlpD,Pyr_redox_2
REGS1_k127_816358_2	1121405.dsmv_0617	4.7e-185	587.0	COG1148@1|root,COG1148@2|Bacteria,1Q0ZF@1224|Proteobacteria,42NHH@68525|delta/epsilon subdivisions,2WJ6M@28221|Deltaproteobacteria,2MIS1@213118|Desulfobacterales	28221|Deltaproteobacteria	C	FAD dependent oxidoreductase	qmoA	-	-	ko:K16885	-	-	-	-	ko00000	-	-	-	FAD_oxidored,NAD_binding_8,Pyr_redox_2
REGS1_k127_816358_0	1121405.dsmv_0618	0.0	1004.0	COG1053@1|root,COG1053@2|Bacteria,1NZBR@1224|Proteobacteria,42PSJ@68525|delta/epsilon subdivisions,2WJDD@28221|Deltaproteobacteria,2MHWQ@213118|Desulfobacterales	28221|Deltaproteobacteria	C	reductase, alpha subunit	aprA	-	1.8.99.2	ko:K00394	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00596	R00860,R04927,R08553	RC00007,RC01239,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2
REGS1_k127_816358_5	411464.DESPIG_02774	2.78e-65	225.0	COG1146@1|root,COG1146@2|Bacteria,1RC9N@1224|Proteobacteria,42QXF@68525|delta/epsilon subdivisions,2WMRJ@28221|Deltaproteobacteria,2M9TJ@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	reductase, beta subunit	aprB	-	1.8.99.2	ko:K00395	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00596	R00860,R04927,R08553	RC00007,RC01239,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	APS-reductase_C,Fer4,Fer4_9
REGS1_k127_816358_4	870187.Thini_2817	7.899e-110	356.0	COG2046@1|root,COG2046@2|Bacteria,1MUQB@1224|Proteobacteria,1RP4Q@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Belongs to the sulfate adenylyltransferase family	sat	-	2.7.7.4	ko:K00958	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-sulfurylase,PUA_2
REGS1_k127_8194497_1	316067.Geob_2945	5.815e-43	162.0	COG0664@1|root,COG0664@2|Bacteria,1MXID@1224|Proteobacteria,42TZY@68525|delta/epsilon subdivisions,2WRWF@28221|Deltaproteobacteria,43UKD@69541|Desulfuromonadales	28221|Deltaproteobacteria	K	Bacterial regulatory proteins, crp family	fnr-2	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
REGS1_k127_8194497_0	177437.HRM2_25580	3.217e-170	561.0	COG0457@1|root,COG3307@1|root,COG0457@2|Bacteria,COG3307@2|Bacteria,1N225@1224|Proteobacteria,42QDQ@68525|delta/epsilon subdivisions,2WM6B@28221|Deltaproteobacteria,2MIM4@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Lipid A core-O-antigen ligase-like enyme	-	-	-	ko:K18814	-	-	-	-	ko00000,ko02000	9.B.67.1	-	-	TPR_14,TPR_16,TPR_8,Wzy_C
REGS1_k127_8194497_2	1232410.KI421421_gene3363	4.616e-17	83.0	COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,1MVI9@1224|Proteobacteria,42NB4@68525|delta/epsilon subdivisions,2WK9E@28221|Deltaproteobacteria,43U6P@69541|Desulfuromonadales	28221|Deltaproteobacteria	DM	Chain length determinant protein	wzc2	-	-	ko:K16554	ko05111,map05111	-	-	-	ko00000,ko00001,ko02000	8.A.3.1	-	-	AAA_31,CbiA,GNVR,ParA,Wzz
REGS1_k127_8202881_3	289376.THEYE_A1068	2.539e-07	60.0	COG2812@1|root,COG2812@2|Bacteria,3J0DD@40117|Nitrospirae	40117|Nitrospirae	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
REGS1_k127_8202881_2	289376.THEYE_A1069	6.997e-38	145.0	COG0718@1|root,COG0718@2|Bacteria,3J1EY@40117|Nitrospirae	40117|Nitrospirae	L	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection	-	-	-	ko:K09747	-	-	-	-	ko00000	-	-	-	YbaB_DNA_bd
REGS1_k127_8202881_1	580327.Tthe_0052	3.295e-70	243.0	COG0353@1|root,COG0353@2|Bacteria,1TR87@1239|Firmicutes,2487H@186801|Clostridia,42F7S@68295|Thermoanaerobacterales	186801|Clostridia	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	-	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	HHH,RecR,Toprim_4
REGS1_k127_8202881_0	760568.Desku_0156	2.735e-105	355.0	COG1171@1|root,COG1171@2|Bacteria,1TP22@1239|Firmicutes,248D5@186801|Clostridia,2615A@186807|Peptococcaceae	186801|Clostridia	E	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA	ilvA	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT_4,PALP
REGS1_k127_8231411_2	861450.HMPREF0080_00897	3.711e-27	119.0	COG4659@1|root,COG4659@2|Bacteria,1V7R1@1239|Firmicutes,4H4F7@909932|Negativicutes	909932|Negativicutes	C	Part of a membrane complex involved in electron transport	rnfG	-	-	ko:K03612	-	-	-	-	ko00000	-	-	-	FMN_bind
REGS1_k127_8231411_1	401526.TcarDRAFT_1671	9.299e-106	353.0	COG4658@1|root,COG4658@2|Bacteria,1TQAY@1239|Firmicutes,4H2AN@909932|Negativicutes	909932|Negativicutes	C	Part of a membrane complex involved in electron transport	rnfD	-	-	ko:K03614	-	-	-	-	ko00000	-	-	-	NQR2_RnfD_RnfE
REGS1_k127_8231411_0	1121289.JHVL01000002_gene2432	1.711e-153	497.0	COG4656@1|root,COG4656@2|Bacteria,1TPCC@1239|Firmicutes,24805@186801|Clostridia,36F8C@31979|Clostridiaceae	186801|Clostridia	C	Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily	rnfC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03615	-	-	-	-	ko00000	-	-	-	Complex1_51K,Fer4,Fer4_10,Fer4_7,Fer4_9,RnfC_N,SLBB
REGS1_k127_8255976_3	309799.DICTH_0585	1.786e-53	212.0	COG2203@1|root,COG5002@1|root,COG2203@2|Bacteria,COG5002@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	saeS	-	2.7.13.3,4.6.1.1	ko:K01768,ko:K02484,ko:K07636,ko:K10681,ko:K10819,ko:K18350,ko:K20487	ko00230,ko01502,ko02020,ko02024,ko02025,ko04113,ko04213,map00230,map01502,map02020,map02024,map02025,map04113,map04213	M00434,M00468,M00652,M00657,M00695,M00816	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000,ko01001,ko01504,ko02022	-	-	-	HAMP,HATPase_c,HisKA
REGS1_k127_8255976_4	272123.Anacy_1659	1.468e-27	117.0	COG0745@1|root,COG0745@2|Bacteria,1G5XG@1117|Cyanobacteria,1HNG1@1161|Nostocales	1117|Cyanobacteria	T	PFAM response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
REGS1_k127_8255976_2	247490.KSU1_C1129	7.967e-60	221.0	COG2203@1|root,COG2206@1|root,COG2203@2|Bacteria,COG2206@2|Bacteria,2IWTK@203682|Planctomycetes	203682|Planctomycetes	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HD
REGS1_k127_8255976_0	289376.THEYE_A1260	2.079e-173	555.0	COG0084@1|root,COG0535@1|root,COG0084@2|Bacteria,COG0535@2|Bacteria,3J0KM@40117|Nitrospirae	40117|Nitrospirae	L	TatD related DNase	-	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_14,Radical_SAM,TatD_DNase
REGS1_k127_8255976_1	1123376.AUIU01000012_gene1424	4.284e-98	326.0	COG3635@1|root,COG3635@2|Bacteria	2|Bacteria	G	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity	apgM	-	5.4.2.12	ko:K15635	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,PhosphMutase
REGS1_k127_8294731_2	289376.THEYE_A1374	4.221e-38	147.0	COG0589@1|root,COG0589@2|Bacteria	2|Bacteria	T	AMP binding	-	-	-	-	-	-	-	-	-	-	-	-	Usp
REGS1_k127_8294731_1	289376.THEYE_A0112	6.847e-198	621.0	COG0192@1|root,COG0192@2|Bacteria,3J0A4@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
REGS1_k127_8294731_0	289376.THEYE_A0111	2.573e-204	642.0	COG0499@1|root,COG0499@2|Bacteria,3J0AH@40117|Nitrospirae	40117|Nitrospirae	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
REGS1_k127_8294731_3	338969.Rfer_0250	1.038e-18	93.0	2DXQM@1|root,3461T@2|Bacteria,1P2RH@1224|Proteobacteria	1224|Proteobacteria	C	Doubled CXXCH motif (Paired_CXXCH_1)	-	-	-	-	-	-	-	-	-	-	-	-	Paired_CXXCH_1
REGS1_k127_831555_1	289376.THEYE_A1341	2.202e-105	347.0	COG1692@1|root,COG1692@2|Bacteria,3J0JW@40117|Nitrospirae	40117|Nitrospirae	S	YmdB-like protein	-	-	-	ko:K09769	-	-	-	-	ko00000	-	-	-	YmdB
REGS1_k127_831555_0	289376.THEYE_A1342	7.142e-206	652.0	COG1418@1|root,COG1418@2|Bacteria,3J0C8@40117|Nitrospirae	40117|Nitrospirae	S	Endoribonuclease that initiates mRNA decay	rny	-	-	ko:K18682	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DUF3552,HD,KH_1
REGS1_k127_831555_2	865861.AZSU01000003_gene1916	2.587e-87	296.0	COG2256@1|root,COG2256@2|Bacteria,1TPVV@1239|Firmicutes,247X2@186801|Clostridia,36EXD@31979|Clostridiaceae	186801|Clostridia	L	AAA ATPase	rarA	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
REGS1_k127_8316668_0	1123376.AUIU01000016_gene222	3.831e-280	869.0	COG1053@1|root,COG1053@2|Bacteria,3J0ZM@40117|Nitrospirae	40117|Nitrospirae	C	Fumarate reductase flavoprotein C-term	-	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
REGS1_k127_8316668_1	289376.THEYE_A0769	1.01e-20	92.0	COG0281@1|root,COG0281@2|Bacteria,3J0WV@40117|Nitrospirae	40117|Nitrospirae	C	Malic enzyme, NAD binding domain	-	-	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	-	R00214	RC00105	ko00000,ko00001,ko01000	-	-	-	ACT_4,Malic_M,malic
REGS1_k127_8375696_0	243231.GSU0946	3.533e-165	533.0	COG5000@1|root,COG5001@1|root,COG5000@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,42M0W@68525|delta/epsilon subdivisions,2WIK8@28221|Deltaproteobacteria,43SWK@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	sensor diguanylate cyclase phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	iAF987.Gmet_0700	EAL,GGDEF,HAMP,PAS_4,PAS_9
REGS1_k127_8375696_6	96561.Dole_2370	0.0009232	49.0	2EC3H@1|root,3362D@2|Bacteria,1NDXP@1224|Proteobacteria,42WQJ@68525|delta/epsilon subdivisions,2WRNF@28221|Deltaproteobacteria,2MKWZ@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PilZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PilZ
REGS1_k127_8375696_2	247490.KSU1_C0709	1.101e-55	198.0	COG1633@1|root,COG1633@2|Bacteria,2J3M5@203682|Planctomycetes	203682|Planctomycetes	S	Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
REGS1_k127_8375696_5	243231.GSU3425	8.756e-30	130.0	2DE9Y@1|root,2ZM4N@2|Bacteria,1Q17X@1224|Proteobacteria,43756@68525|delta/epsilon subdivisions,2X21C@28221|Deltaproteobacteria,43SFZ@69541|Desulfuromonadales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_8375696_4	243159.AFE_2362	2.564e-31	128.0	COG3118@1|root,COG3118@2|Bacteria,1RHUA@1224|Proteobacteria,1S64W@1236|Gammaproteobacteria,2NCWE@225057|Acidithiobacillales	225057|Acidithiobacillales	O	Thioredoxin	-	-	1.8.1.8	ko:K03672	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Thioredoxin
REGS1_k127_8375696_1	316067.Geob_0403	1.696e-134	439.0	COG2876@1|root,COG2876@2|Bacteria,1QVAD@1224|Proteobacteria,42MU4@68525|delta/epsilon subdivisions,2WJ8Y@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	PFAM DAHP synthetase I KDSA	aroG-1	-	2.5.1.54,5.4.99.5	ko:K03856,ko:K04516	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022,M00024,M00025	R01715,R01826	RC00435,RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	CM_2,DAHP_synth_1
REGS1_k127_8375696_3	1192034.CAP_2190	1.539e-38	160.0	COG5184@1|root,COG5184@2|Bacteria	2|Bacteria	DZ	guanyl-nucleotide exchange factor activity	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,Cu-binding_MopE,OppC_N,RCC1,RCC1_2
REGS1_k127_8398545_0	56780.SYN_02802	1.285e-63	228.0	COG0457@1|root,COG0500@1|root,COG4627@1|root,COG4641@1|root,COG0457@2|Bacteria,COG2226@2|Bacteria,COG4627@2|Bacteria,COG4641@2|Bacteria,1Q4D0@1224|Proteobacteria,42W29@68525|delta/epsilon subdivisions,2WRHF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_2
REGS1_k127_8437959_7	289376.THEYE_A1545	1.667e-27	121.0	COG1734@1|root,COG1734@2|Bacteria,3J0R1@40117|Nitrospirae	40117|Nitrospirae	T	Prokaryotic dksA/traR C4-type zinc finger	-	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
REGS1_k127_8437959_5	207559.Dde_1128	1.491e-65	229.0	COG0233@1|root,COG0233@2|Bacteria,1N66T@1224|Proteobacteria,42NAA@68525|delta/epsilon subdivisions,2WNMN@28221|Deltaproteobacteria,2M8XC@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	GO:0002181,GO:0002184,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
REGS1_k127_8437959_1	1123376.AUIU01000016_gene309	2.745e-110	361.0	COG0528@1|root,COG0528@2|Bacteria,3J0BE@40117|Nitrospirae	40117|Nitrospirae	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
REGS1_k127_8437959_3	289376.THEYE_A1542	1.615e-85	287.0	COG0264@1|root,COG0264@2|Bacteria,3J0I2@40117|Nitrospirae	40117|Nitrospirae	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
REGS1_k127_8437959_2	1120973.AQXL01000128_gene2825	1.207e-102	341.0	COG0052@1|root,COG0052@2|Bacteria,1TPNA@1239|Firmicutes,4H9N5@91061|Bacilli,27885@186823|Alicyclobacillaceae	91061|Bacilli	J	Belongs to the universal ribosomal protein uS2 family	rpsB	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
REGS1_k127_8437959_6	247490.KSU1_D0614	1.675e-43	166.0	COG1648@1|root,COG1648@2|Bacteria,2J0PN@203682|Planctomycetes	203682|Planctomycetes	H	Putative NAD(P)-binding	-	-	1.3.1.76,4.99.1.4	ko:K02304	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03947	RC01012,RC01034	ko00000,ko00001,ko00002,ko01000	-	-	-	NAD_binding_7,Sirohm_synth_M
REGS1_k127_8437959_4	289376.THEYE_A0831	3.211e-70	245.0	COG4105@1|root,COG4105@2|Bacteria,3J0UU@40117|Nitrospirae	40117|Nitrospirae	S	Tetratricopeptide repeat	-	-	-	ko:K05807	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	YfiO
REGS1_k127_8437959_0	1123376.AUIU01000011_gene968	8.657e-141	460.0	COG1032@1|root,COG5011@1|root,COG1032@2|Bacteria,COG5011@2|Bacteria	2|Bacteria	C	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF2344,Radical_SAM
REGS1_k127_8455000_1	1121422.AUMW01000045_gene1207	4.237e-35	140.0	COG4191@1|root,COG4191@2|Bacteria,1UMSI@1239|Firmicutes,25GPV@186801|Clostridia,267GQ@186807|Peptococcaceae	186801|Clostridia	T	His Kinase A (phosphoacceptor) domain	-	-	2.7.13.3	ko:K07709	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA
REGS1_k127_8455000_0	289376.THEYE_A1802	1.267e-176	565.0	COG2204@1|root,COG2204@2|Bacteria,3J10B@40117|Nitrospirae	40117|Nitrospirae	T	Sigma-54 interaction domain	-	-	-	ko:K07714	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
REGS1_k127_8463858_2	644966.Tmar_0901	2.759e-52	190.0	COG0045@1|root,COG1042@1|root,COG1670@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG1670@2|Bacteria,1TPTQ@1239|Firmicutes,249CX@186801|Clostridia,3WD0A@538999|Clostridiales incertae sedis	186801|Clostridia	C	TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain	-	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,Acetyltransf_1,CoA_binding_2,Succ_CoA_lig
REGS1_k127_8463858_3	1304885.AUEY01000145_gene1077	2.295e-45	168.0	COG5611@1|root,COG5611@2|Bacteria,1NDBN@1224|Proteobacteria,42VV9@68525|delta/epsilon subdivisions	1224|Proteobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
REGS1_k127_8463858_4	639282.DEFDS_0395	3.701e-12	69.0	2E3UR@1|root,32YS2@2|Bacteria	2|Bacteria	S	SpoVT / AbrB like domain	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin
REGS1_k127_8463858_0	1123376.AUIU01000013_gene1709	6.732e-157	504.0	COG0343@1|root,COG0343@2|Bacteria,3J0DU@40117|Nitrospirae	40117|Nitrospirae	F	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046116,GO:0046483,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
REGS1_k127_8463858_1	1304885.AUEY01000094_gene3536	4.358e-86	289.0	COG2199@1|root,COG3706@2|Bacteria,1N2X1@1224|Proteobacteria,42TUZ@68525|delta/epsilon subdivisions,2WQ1Q@28221|Deltaproteobacteria,2MKGE@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Carbohydrate-binding family 9	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_2
REGS1_k127_847247_0	289376.THEYE_A1872	1.573e-195	623.0	COG0210@1|root,COG0210@2|Bacteria,3J0VX@40117|Nitrospirae	40117|Nitrospirae	L	UvrD-like helicase C-terminal domain	-	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
REGS1_k127_847247_6	35841.BT1A1_0631	1.268e-23	103.0	COG0721@1|root,COG0721@2|Bacteria,1VEK3@1239|Firmicutes,4HNNA@91061|Bacilli,1ZH54@1386|Bacillus	91061|Bacilli	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	-	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Glu-tRNAGln
REGS1_k127_847247_5	330214.NIDE2919	2.267e-39	149.0	COG0853@1|root,COG0853@2|Bacteria,3J0Q2@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine	panD	-	4.1.1.11	ko:K01579	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R00489	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Asp_decarbox
REGS1_k127_847247_2	1121396.KB892918_gene90	5.014e-88	296.0	COG0398@1|root,COG0398@2|Bacteria,1MVF3@1224|Proteobacteria,42PFC@68525|delta/epsilon subdivisions,2WKDP@28221|Deltaproteobacteria,2MIRM@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
REGS1_k127_847247_1	575540.Isop_3507	9.149e-100	335.0	COG0535@1|root,COG0535@2|Bacteria,2IXC0@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF3641)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3641,Radical_SAM
REGS1_k127_847247_3	324925.Ppha_1105	1.197e-86	293.0	COG1462@1|root,COG1462@2|Bacteria	2|Bacteria	M	curli production assembly transport component CsgG	-	-	-	-	-	-	-	-	-	-	-	-	CsgG
REGS1_k127_847247_4	32057.KB217478_gene6749	3.817e-43	159.0	COG3408@1|root,COG3408@2|Bacteria,1GQ41@1117|Cyanobacteria,1HUCI@1161|Nostocales	1117|Cyanobacteria	G	PFAM Mannosyl oligosaccharide glucosidase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_63
REGS1_k127_8474705_3	903814.ELI_3514	2.851e-25	108.0	COG0491@1|root,COG0491@2|Bacteria,1V6FA@1239|Firmicutes,24JGV@186801|Clostridia,25WHB@186806|Eubacteriaceae	186801|Clostridia	S	Metallo-beta-lactamase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
REGS1_k127_8474705_0	289376.THEYE_A1108	3.132e-163	529.0	COG0728@1|root,COG0728@2|Bacteria,3J0CQ@40117|Nitrospirae	40117|Nitrospirae	S	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
REGS1_k127_8474705_1	1121324.CLIT_8c00250	5.589e-66	235.0	COG0134@1|root,COG0134@2|Bacteria,1TR94@1239|Firmicutes,249ZY@186801|Clostridia	186801|Clostridia	E	Belongs to the TrpC family	trpC	-	4.1.1.48	ko:K01609	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508	RC00944	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS
REGS1_k127_8474705_2	1123376.AUIU01000019_gene1240	1.625e-41	159.0	COG0810@1|root,COG0810@2|Bacteria	2|Bacteria	M	energy transducer activity	tonB3	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_2,TonB_C
REGS1_k127_8481252_5	330214.NIDE1378	8.081e-44	163.0	COG0459@1|root,COG0459@2|Bacteria,3J0DA@40117|Nitrospirae	40117|Nitrospirae	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
REGS1_k127_8481252_7	1162668.LFE_1520	1.531e-35	137.0	COG0234@1|root,COG0234@2|Bacteria,3J0RF@40117|Nitrospirae	40117|Nitrospirae	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009987,GO:0010033,GO:0035966,GO:0042221,GO:0043167,GO:0043169,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0061077	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
REGS1_k127_8481252_4	316067.Geob_2164	8.394e-48	182.0	COG0745@1|root,COG0745@2|Bacteria,1NV0N@1224|Proteobacteria,42ZH3@68525|delta/epsilon subdivisions,2WUW0@28221|Deltaproteobacteria,43UQG@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	zinc-ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,zinc_ribbon_4
REGS1_k127_8481252_2	1379698.RBG1_1C00001G0457	1.134e-63	225.0	COG0705@1|root,COG0705@2|Bacteria,2NPGI@2323|unclassified Bacteria	2|Bacteria	S	(Rhomboid) family	GlpG	-	-	ko:K07059	-	-	-	-	ko00000	-	-	-	Rhomboid
REGS1_k127_8481252_3	555079.Toce_0694	3.533e-49	181.0	COG0323@1|root,COG0323@2|Bacteria,1UK25@1239|Firmicutes,25G0Z@186801|Clostridia	186801|Clostridia	L	SMART ATP-binding region ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
REGS1_k127_8481252_1	706587.Desti_2749	1.529e-64	229.0	COG0613@1|root,COG0613@2|Bacteria,1N68X@1224|Proteobacteria,42TYN@68525|delta/epsilon subdivisions,2WR34@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PHP-associated	-	-	3.1.3.97	ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	PHP_C
REGS1_k127_8481252_8	706587.Desti_2748	2.141e-31	128.0	COG4109@1|root,COG4109@2|Bacteria	2|Bacteria	K	DRTGG domain	-	-	-	-	-	-	-	-	-	-	-	-	DRTGG
REGS1_k127_8481252_6	309799.DICTH_0761	1.759e-42	162.0	COG2172@1|root,COG2524@1|root,COG2172@2|Bacteria,COG2524@2|Bacteria	2|Bacteria	K	Domain in cystathionine beta-synthase and other proteins.	RsbW	-	5.3.1.13	ko:K06041	ko00540,ko01100,map00540,map01100	M00063	R01530	RC00541	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CBS,HATPase_c,HATPase_c_2
REGS1_k127_8481252_9	401526.TcarDRAFT_1701	7.593e-29	119.0	COG2172@1|root,COG2172@2|Bacteria,1UJ84@1239|Firmicutes,4H9AW@909932|Negativicutes	909932|Negativicutes	T	DRTGG domain	-	-	-	-	-	-	-	-	-	-	-	-	DRTGG
REGS1_k127_8481252_0	767817.Desgi_2136	6.204e-87	306.0	COG3383@1|root,COG3383@2|Bacteria,1UI1F@1239|Firmicutes,25EAG@186801|Clostridia,260KC@186807|Peptococcaceae	186801|Clostridia	C	TIGRFAM formate dehydrogenase, alpha subunit	-	-	1.17.1.10,1.6.5.3	ko:K00336,ko:K05299	ko00190,ko00680,ko00720,ko01100,ko01120,ko01200,map00190,map00680,map00720,map01100,map01120,map01200	M00144,M00377	R00134,R11945	RC00061,RC02796	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Fer4,Fer4_6,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
REGS1_k127_8500622_8	1397699.JNIS01000001_gene2018	8.09e-18	83.0	COG4895@1|root,COG4895@2|Bacteria,1VEG3@1239|Firmicutes,4HNJA@91061|Bacilli	91061|Bacilli	S	Uncharacterized conserved protein (DUF2196)	ywbE	-	-	-	-	-	-	-	-	-	-	-	DUF2196
REGS1_k127_8500622_4	667014.Thein_1938	7.34e-35	139.0	COG1569@1|root,COG1569@2|Bacteria	2|Bacteria	S	PIN domain	-	-	-	ko:K07063	-	-	-	-	ko00000	-	-	-	PIN_3
REGS1_k127_8500622_7	667014.Thein_1939	7.866e-20	91.0	COG3905@1|root,COG3905@2|Bacteria	2|Bacteria	K	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1
REGS1_k127_8500622_6	269799.Gmet_3077	2.044e-30	122.0	COG4118@1|root,COG4118@2|Bacteria,1P7XR@1224|Proteobacteria,4327E@68525|delta/epsilon subdivisions,2WY4C@28221|Deltaproteobacteria	28221|Deltaproteobacteria	D	Antitoxin Phd_YefM, type II toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
REGS1_k127_8500622_3	269799.Gmet_3076	1.266e-42	160.0	COG1848@1|root,COG1848@2|Bacteria,1MYDN@1224|Proteobacteria,42X7T@68525|delta/epsilon subdivisions,2WT7N@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	PIN
REGS1_k127_8500622_9	1265505.ATUG01000001_gene4031	4.315e-17	81.0	COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,42M27@68525|delta/epsilon subdivisions,2WJ2S@28221|Deltaproteobacteria,2MHVY@213118|Desulfobacterales	28221|Deltaproteobacteria	NT	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	cheB34H	-	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,Response_reg
REGS1_k127_8500622_5	269799.Gmet_0856	3.572e-31	130.0	COG0457@1|root,COG0457@2|Bacteria,1N0Q1@1224|Proteobacteria,42TBT@68525|delta/epsilon subdivisions,2WPII@28221|Deltaproteobacteria,43V2H@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_2,TPR_8
REGS1_k127_8500622_0	289376.THEYE_A1889	1.098e-173	563.0	COG0322@1|root,COG0322@2|Bacteria,3J0F1@40117|Nitrospirae	40117|Nitrospirae	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_5,UVR,UvrC_HhH_N
REGS1_k127_8500622_1	880072.Desac_2570	7.322e-116	381.0	COG0524@1|root,COG0524@2|Bacteria,1QMIR@1224|Proteobacteria,42NDK@68525|delta/epsilon subdivisions,2WK15@28221|Deltaproteobacteria,2MR2Z@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	PFAM PfkB	-	-	2.7.1.20	ko:K00856	ko00230,ko01100,map00230,map01100	-	R00185	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
REGS1_k127_8500622_2	1283300.ATXB01000002_gene2900	2.447e-88	294.0	COG4977@1|root,COG4977@2|Bacteria,1MUDK@1224|Proteobacteria,1S32F@1236|Gammaproteobacteria,1XEVA@135618|Methylococcales	135618|Methylococcales	K	DJ-1/PfpI family	-	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI,HTH_18
REGS1_k127_8547224_4	56780.SYN_01600	2.04e-41	153.0	COG0522@1|root,COG0522@2|Bacteria,1MW0U@1224|Proteobacteria,42M5X@68525|delta/epsilon subdivisions,2WJGN@28221|Deltaproteobacteria,2MRHQ@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
REGS1_k127_8547224_2	56780.SYN_01599	1.05e-65	226.0	COG0100@1|root,COG0100@2|Bacteria,1RD0A@1224|Proteobacteria,42R43@68525|delta/epsilon subdivisions,2WPH1@28221|Deltaproteobacteria,2MQGH@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome	rpsK	GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
REGS1_k127_8547224_3	56780.SYN_01598	9.885e-60	208.0	COG0099@1|root,COG0099@2|Bacteria,1RD1G@1224|Proteobacteria,42RE3@68525|delta/epsilon subdivisions,2WPD5@28221|Deltaproteobacteria,2MRU2@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
REGS1_k127_8547224_6	537970.HCAN_0594	2.763e-13	70.0	COG0257@1|root,COG0257@2|Bacteria,1NGEI@1224|Proteobacteria,42WXD@68525|delta/epsilon subdivisions,2YQQ9@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	J	Belongs to the bacterial ribosomal protein bL36 family	rpmJ	-	-	ko:K02919	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L36
REGS1_k127_8547224_5	56780.SYN_01597	9.139e-37	142.0	COG0361@1|root,COG0361@2|Bacteria,1MZFU@1224|Proteobacteria,42TRU@68525|delta/epsilon subdivisions,2WPZK@28221|Deltaproteobacteria,2MQKC@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
REGS1_k127_8547224_0	56780.SYN_01596	1.721e-108	356.0	COG0024@1|root,COG0024@2|Bacteria,1MU99@1224|Proteobacteria,42MM5@68525|delta/epsilon subdivisions,2WJMN@28221|Deltaproteobacteria,2MQB2@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	TIGRFAM methionine aminopeptidase, type I	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
REGS1_k127_8547224_1	56780.SYN_01595	9.481e-68	231.0	COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,42MGM@68525|delta/epsilon subdivisions,2WIZ7@28221|Deltaproteobacteria,2MQSV@213462|Syntrophobacterales	28221|Deltaproteobacteria	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
REGS1_k127_8563492_6	1123376.AUIU01000016_gene291	2.585e-24	104.0	COG0165@1|root,COG0165@2|Bacteria,3J0EN@40117|Nitrospirae	40117|Nitrospirae	E	Argininosuccinate lyase C-terminal	argH	-	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
REGS1_k127_8563492_7	398767.Glov_1772	2.843e-15	82.0	COG1639@1|root,COG1639@2|Bacteria,1RASR@1224|Proteobacteria	1224|Proteobacteria	T	HDOD domain	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
REGS1_k127_8563492_0	330214.NIDE0344	4.69e-103	343.0	COG0714@1|root,COG0714@2|Bacteria,3J0WQ@40117|Nitrospirae	40117|Nitrospirae	S	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
REGS1_k127_8563492_5	321327.CYA_2265	4.725e-26	120.0	COG1721@1|root,COG1721@2|Bacteria,1G15B@1117|Cyanobacteria,1GZR9@1129|Synechococcus	1117|Cyanobacteria	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
REGS1_k127_8563492_3	330214.NIDE0342	1.024e-60	233.0	COG1305@1|root,COG1305@2|Bacteria,3J150@40117|Nitrospirae	40117|Nitrospirae	E	Transglutaminase/protease-like homologues	-	-	-	-	-	-	-	-	-	-	-	-	DUF3488,Transglut_core
REGS1_k127_8563492_1	1519464.HY22_13745	7.83e-88	299.0	COG0618@1|root,COG0618@2|Bacteria,1FEID@1090|Chlorobi	1090|Chlorobi	S	3'(2'),5'-bisphosphate nucleotidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_8563492_2	289376.THEYE_A1497	3.075e-76	261.0	COG2518@1|root,COG2518@2|Bacteria	2|Bacteria	O	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
REGS1_k127_8563492_4	1031288.AXAA01000015_gene313	6.257e-34	131.0	COG2509@1|root,COG2509@2|Bacteria,1TP9I@1239|Firmicutes,247QM@186801|Clostridia,36F3G@31979|Clostridiaceae	186801|Clostridia	S	Oxidoreductase	-	-	-	ko:K07137	-	-	-	-	ko00000	-	-	-	FAD_binding_2,HI0933_like,Pyr_redox_2,Thi4
REGS1_k127_858956_0	1121918.ARWE01000001_gene1396	1.857e-124	402.0	COG2805@1|root,COG2805@2|Bacteria,1R6FY@1224|Proteobacteria,42MPJ@68525|delta/epsilon subdivisions,2WK57@28221|Deltaproteobacteria,43SCV@69541|Desulfuromonadales	28221|Deltaproteobacteria	NU	Type II/IV secretion system protein	pilT-2	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
REGS1_k127_8596486_0	909663.KI867150_gene1129	1.065e-169	541.0	COG1322@1|root,COG1322@2|Bacteria,1MWHV@1224|Proteobacteria,42NDS@68525|delta/epsilon subdivisions,2WJDE@28221|Deltaproteobacteria,2MQKI@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	RmuC family	-	-	-	ko:K09760	-	-	-	-	ko00000	-	-	-	RmuC
REGS1_k127_8596486_1	909663.KI867150_gene2187	6.224e-94	315.0	COG0744@1|root,COG0744@2|Bacteria,1RDAQ@1224|Proteobacteria,42MBJ@68525|delta/epsilon subdivisions,2WNWX@28221|Deltaproteobacteria,2MQKM@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors	mtgA	-	2.4.1.129	ko:K03814	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly
REGS1_k127_8630617_3	1356854.N007_14890	2.033e-13	72.0	COG1173@1|root,COG1173@2|Bacteria,1TP4R@1239|Firmicutes,4HA7I@91061|Bacilli	91061|Bacilli	P	ABC transporter (Permease	appC	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
REGS1_k127_8630617_1	889378.Spiaf_2073	1.622e-81	281.0	COG0601@1|root,COG0601@2|Bacteria,2J635@203691|Spirochaetes	203691|Spirochaetes	P	Permease	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
REGS1_k127_8630617_0	926561.KB900620_gene2911	4.531e-109	371.0	COG4166@1|root,COG4166@2|Bacteria,1TNYQ@1239|Firmicutes,25E4B@186801|Clostridia	186801|Clostridia	E	Family 5	-	-	-	ko:K02035,ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	SBP_bac_5
REGS1_k127_8630617_2	1123376.AUIU01000016_gene340	1.071e-35	142.0	COG2071@1|root,COG2071@2|Bacteria,3J0PV@40117|Nitrospirae	40117|Nitrospirae	S	Peptidase C26	-	-	-	ko:K07010	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_C26
REGS1_k127_8643261_1	1121423.JONT01000014_gene1270	9.772e-69	243.0	COG0702@1|root,COG0702@2|Bacteria,1UNU6@1239|Firmicutes	1239|Firmicutes	GM	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_8643261_2	697284.ERIC2_c19740	3.816e-57	207.0	COG1838@1|root,COG1951@1|root,COG1838@2|Bacteria,COG1951@2|Bacteria,1TPXQ@1239|Firmicutes,4HA3C@91061|Bacilli,26R8Y@186822|Paenibacillaceae	91061|Bacilli	C	Catalyzes the reversible hydration of fumarate to (S)- malate	fumA	-	4.2.1.2	ko:K01676	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase,Fumerase_C
REGS1_k127_8643261_0	926569.ANT_30960	4.326e-83	284.0	COG1951@1|root,COG1951@2|Bacteria,2G6YI@200795|Chloroflexi	200795|Chloroflexi	C	Fumarate hydratase (Fumerase)	-	-	4.2.1.2	ko:K01676,ko:K01677	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase
REGS1_k127_8643261_5	555779.Dthio_PD0649	1.61e-06	56.0	COG0607@1|root,COG1633@1|root,COG0607@2|Bacteria,COG1633@2|Bacteria,1RJ9V@1224|Proteobacteria,42TC5@68525|delta/epsilon subdivisions,2WPNB@28221|Deltaproteobacteria,2MBYN@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	PFAM Rhodanese domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese,Rubrerythrin
REGS1_k127_8643261_3	1227352.C173_12557	2.615e-34	139.0	COG2345@1|root,COG2345@2|Bacteria,1V3GF@1239|Firmicutes,4HG9G@91061|Bacilli,275GJ@186822|Paenibacillaceae	91061|Bacilli	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_11,HTH_20
REGS1_k127_8643261_4	1051501.AYTL01000030_gene3087	3.438e-15	78.0	COG0156@1|root,COG0156@2|Bacteria,1TPUX@1239|Firmicutes,4HAH3@91061|Bacilli,1ZAUZ@1386|Bacillus	91061|Bacilli	H	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide	bioF	GO:0003674,GO:0003824,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008710,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.3.1.29,2.3.1.47	ko:K00639,ko:K00652	ko00260,ko00780,ko01100,map00260,map00780,map01100	M00123,M00573,M00577	R00371,R03210,R10124	RC00004,RC00039,RC00394,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iSB619.SA_RS12695	Aminotran_1_2
REGS1_k127_866331_6	671143.DAMO_0253	9.499e-12	67.0	COG4552@1|root,COG4552@2|Bacteria	2|Bacteria	S	transferase activity, transferring acyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_9,SCP2_2
REGS1_k127_866331_3	1304888.ATWF01000002_gene387	3.481e-38	156.0	COG0535@1|root,COG0535@2|Bacteria,2GGI6@200930|Deferribacteres	200930|Deferribacteres	C	Iron-sulfur cluster-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM,SPASM
REGS1_k127_866331_5	1122971.BAME01000048_gene4063	2.167e-21	106.0	COG0500@1|root,COG2226@2|Bacteria,4NIQW@976|Bacteroidetes,2FMDT@200643|Bacteroidia	976|Bacteroidetes	Q	Methionine biosynthesis protein MetW	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
REGS1_k127_866331_4	1280680.AUJU01000005_gene1531	4.632e-27	121.0	COG0535@1|root,COG0535@2|Bacteria,1VSHZ@1239|Firmicutes,24YKW@186801|Clostridia,4BXWK@830|Butyrivibrio	186801|Clostridia	S	Iron-sulfur cluster-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
REGS1_k127_866331_7	1123514.KB905899_gene1629	2.851e-05	55.0	COG4261@1|root,COG4261@2|Bacteria,1MVXJ@1224|Proteobacteria,1RNKV@1236|Gammaproteobacteria,461DQ@72273|Thiotrichales	72273|Thiotrichales	S	Bacterial lipid A biosynthesis acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Lip_A_acyltrans
REGS1_k127_866331_1	1304885.AUEY01000002_gene324	7.156e-65	240.0	COG1032@1|root,COG1032@2|Bacteria,1NRWP@1224|Proteobacteria,42S72@68525|delta/epsilon subdivisions,2WNA6@28221|Deltaproteobacteria,2MKAP@213118|Desulfobacterales	28221|Deltaproteobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
REGS1_k127_866331_0	671143.DAMO_0252	2.699e-94	329.0	COG1134@1|root,COG1134@2|Bacteria,2NP4S@2323|unclassified Bacteria	2|Bacteria	GM	ATPases associated with a variety of cellular activities	-	-	3.6.3.38	ko:K09689,ko:K09691	ko02010,map02010	M00249,M00250	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.101,3.A.1.103	-	-	ABC_tran,Wzt_C
REGS1_k127_866331_2	429009.Adeg_0506	1.558e-39	157.0	COG1682@1|root,COG1682@2|Bacteria,1TY8I@1239|Firmicutes,25B42@186801|Clostridia,42FH8@68295|Thermoanaerobacterales	186801|Clostridia	GM	PFAM ABC-2 type transporter	-	-	-	ko:K01992,ko:K09690	ko02010,map02010	M00250,M00254	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.103	-	-	ABC2_membrane
REGS1_k127_86677_1	289376.THEYE_A1041	1.427e-125	431.0	COG4775@1|root,COG4775@2|Bacteria,3J0AC@40117|Nitrospirae	40117|Nitrospirae	M	Surface antigen	-	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
REGS1_k127_86677_0	1123376.AUIU01000014_gene576	3.056e-161	554.0	COG2911@1|root,COG2911@2|Bacteria	2|Bacteria	S	protein secretion	-	-	-	ko:K09800	-	-	-	-	ko00000,ko02000	-	-	-	AsmA_2,DUF748,TamB
REGS1_k127_8696817_0	330214.NIDE2578	1.826e-67	241.0	2F9RH@1|root,3421I@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_8730649_0	1123376.AUIU01000015_gene493	2.72e-239	746.0	COG0459@1|root,COG0459@2|Bacteria,3J0DA@40117|Nitrospirae	40117|Nitrospirae	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
REGS1_k127_8730649_2	289376.THEYE_A0365	1.758e-91	313.0	COG1559@1|root,COG1559@2|Bacteria,3J0IR@40117|Nitrospirae	40117|Nitrospirae	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
REGS1_k127_8730649_1	289376.THEYE_A0366	6.908e-146	470.0	COG0821@1|root,COG0821@2|Bacteria,3J0EA@40117|Nitrospirae	40117|Nitrospirae	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046429,GO:0046490,GO:0052592,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
REGS1_k127_8730649_3	1167006.UWK_00776	1.589e-75	257.0	COG3448@1|root,COG3448@2|Bacteria,1MXJG@1224|Proteobacteria,42RSQ@68525|delta/epsilon subdivisions,2WNED@28221|Deltaproteobacteria,2MJRX@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM HPP family	-	-	-	ko:K07168	-	-	-	-	ko00000	-	-	-	HPP
REGS1_k127_8730649_4	439235.Dalk_3566	6.697e-55	199.0	COG3448@1|root,COG3448@2|Bacteria,1Q1A8@1224|Proteobacteria,42SIQ@68525|delta/epsilon subdivisions,2WPF0@28221|Deltaproteobacteria,2MKBJ@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
REGS1_k127_8730649_5	713586.KB900536_gene2038	1.724e-13	81.0	COG0589@1|root,COG0589@2|Bacteria,1NBKV@1224|Proteobacteria,1SHMY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Universal stress protein family	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE,Usp
REGS1_k127_8737980_1	1123376.AUIU01000016_gene198	1.02e-104	351.0	COG0535@1|root,COG0535@2|Bacteria	2|Bacteria	I	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM
REGS1_k127_8737980_0	247490.KSU1_B0443	2.569e-106	346.0	COG0605@1|root,COG0605@2|Bacteria,2IX16@203682|Planctomycetes	203682|Planctomycetes	C	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	-	-	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
REGS1_k127_8738408_0	289376.THEYE_A1678	1.816e-215	675.0	COG0498@1|root,COG0498@2|Bacteria,3J0FZ@40117|Nitrospirae	40117|Nitrospirae	E	Pyridoxal-phosphate dependent enzyme	thrC1	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
REGS1_k127_8738408_1	289376.THEYE_A1679	1.8e-34	135.0	COG1977@1|root,COG1977@2|Bacteria,3J0T2@40117|Nitrospirae	40117|Nitrospirae	H	ThiS family	-	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
REGS1_k127_8738408_2	289376.THEYE_A1680	1.136e-27	114.0	COG1135@1|root,COG1135@2|Bacteria,3J0VT@40117|Nitrospirae	40117|Nitrospirae	P	NIL	-	-	-	-	-	-	-	-	-	-	-	-	NIL
REGS1_k127_8738408_3	877455.Metbo_1172	1.338e-17	83.0	COG3635@1|root,arCOG01696@2157|Archaea,2XU1U@28890|Euryarchaeota,23NN3@183925|Methanobacteria	183925|Methanobacteria	G	phosphoglycerate mutase	-	-	5.4.2.12	ko:K15635	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,PhosphMutase
REGS1_k127_8739551_2	1094508.Tsac_1304	9.939e-17	84.0	COG5341@1|root,COG5341@2|Bacteria,1VEPD@1239|Firmicutes,24QPH@186801|Clostridia,42GIW@68295|Thermoanaerobacterales	186801|Clostridia	S	NusG domain II	-	-	2.5.1.30	ko:K00805	ko00900,ko01110,map00900,map01110	-	R09247	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	NusG_II
REGS1_k127_8739551_0	1499967.BAYZ01000179_gene4632	5.529e-35	141.0	COG4769@1|root,COG4769@2|Bacteria,2NS0D@2323|unclassified Bacteria	2|Bacteria	S	Heptaprenyl diphosphate synthase component I	hepS	-	2.5.1.30	ko:K00805	ko00900,ko01110,map00900,map01110	-	R09247	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	Hpre_diP_synt_I
REGS1_k127_8739551_1	1217710.F969_01048	5.817e-17	81.0	COG3024@1|root,COG3024@2|Bacteria,1NGJ8@1224|Proteobacteria,1SEPS@1236|Gammaproteobacteria,3NPSB@468|Moraxellaceae	1236|Gammaproteobacteria	S	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase	yacG	-	-	ko:K09862	-	-	-	-	ko00000	-	-	-	YacG
REGS1_k127_8778923_3	322710.Avin_42920	2.312e-15	76.0	COG0782@1|root,COG0782@2|Bacteria,1RCXW@1224|Proteobacteria,1S3UP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	GO:0001098,GO:0001108,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006354,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0032784,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
REGS1_k127_8778923_2	289376.THEYE_A0542	2.358e-58	211.0	COG0543@1|root,COG0543@2|Bacteria	2|Bacteria	C	2 iron, 2 sulfur cluster binding	pyrK	-	1.3.1.14,3.5.2.3	ko:K01465,ko:K02823,ko:K05784,ko:K17828	ko00240,ko00362,ko00364,ko00622,ko01100,ko01120,ko01220,map00240,map00362,map00364,map00622,map01100,map01120,map01220	M00051,M00551	R01869,R01993,R05290,R05291,R05428,R05621,R05622,R05665,R08100,R08101,R08108,R08109,R08110	RC00051,RC00270,RC00632,RC01378,RC01450,RC01910	br01602,ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS17580	DHODB_Fe-S_bind,FAD_binding_6,Fer2,NAD_binding_1
REGS1_k127_8778923_0	56780.SYN_02850	8.865e-119	388.0	COG0167@1|root,COG0167@2|Bacteria,1MU7C@1224|Proteobacteria,42M46@68525|delta/epsilon subdivisions,2WJ7G@28221|Deltaproteobacteria,2MQCF@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	Catalyzes the conversion of dihydroorotate to orotate	pyrD	GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	1.3.1.14,1.3.5.2	ko:K00254,ko:K02823,ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01868,R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
REGS1_k127_8778923_1	289376.THEYE_A0544	2.168e-66	235.0	COG1912@1|root,COG1912@2|Bacteria,3J0RG@40117|Nitrospirae	40117|Nitrospirae	S	S-adenosyl-l-methionine hydroxide adenosyltransferase	-	-	-	ko:K22205	-	-	-	-	ko00000,ko01000	-	-	-	SAM_adeno_trans
REGS1_k127_8784863_1	316067.Geob_3439	4.157e-85	286.0	COG0512@1|root,COG0512@2|Bacteria,1MV5Y@1224|Proteobacteria,42QTS@68525|delta/epsilon subdivisions,2WN02@28221|Deltaproteobacteria,43TCX@69541|Desulfuromonadales	28221|Deltaproteobacteria	EH	TIGRFAM glutamine amidotransferase of anthranilate synthase	trpG	-	2.6.1.85,4.1.3.27	ko:K01658,ko:K01664	ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986,R01716	RC00010,RC01418,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2496	GATase
REGS1_k127_8784863_0	1131269.AQVV01000007_gene1011	4.763e-178	570.0	COG0147@1|root,COG0147@2|Bacteria	2|Bacteria	EH	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
REGS1_k127_8784863_2	1232410.KI421412_gene445	2.404e-23	104.0	2EWA0@1|root,33PNR@2|Bacteria,1NSPR@1224|Proteobacteria,42YN1@68525|delta/epsilon subdivisions,2WTJI@28221|Deltaproteobacteria,43U3D@69541|Desulfuromonadales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_8821753_4	1123376.AUIU01000018_gene71	1.118e-51	184.0	COG0512@1|root,COG0512@2|Bacteria,3J0H8@40117|Nitrospirae	40117|Nitrospirae	EH	Peptidase C26	-	-	4.1.3.27	ko:K01658	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
REGS1_k127_8821753_0	443144.GM21_2012	8.308e-175	557.0	COG0477@1|root,COG2814@2|Bacteria,1NU31@1224|Proteobacteria,43CB2@68525|delta/epsilon subdivisions,2X7MH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	EGP	Major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
REGS1_k127_8821753_1	269799.Gmet_2812	3.731e-101	337.0	COG0524@1|root,COG0524@2|Bacteria,1MUUC@1224|Proteobacteria,42M1U@68525|delta/epsilon subdivisions,2WKK5@28221|Deltaproteobacteria,43USS@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	pfkB family carbohydrate kinase	-	-	2.7.1.15,2.7.1.4	ko:K00847,ko:K00852	ko00030,ko00051,ko00500,ko00520,ko01100,map00030,map00051,map00500,map00520,map01100	-	R00760,R00867,R01051,R02750,R03920	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
REGS1_k127_8821753_2	1121403.AUCV01000008_gene1526	1.528e-75	264.0	COG0727@1|root,COG0727@2|Bacteria,1R3YG@1224|Proteobacteria,42NM0@68525|delta/epsilon subdivisions,2WM96@28221|Deltaproteobacteria,2MHSQ@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
REGS1_k127_8821753_3	335543.Sfum_2995	8.86e-64	220.0	COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,42N1H@68525|delta/epsilon subdivisions,2WJ0R@28221|Deltaproteobacteria,2MQUH@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
REGS1_k127_8833386_7	525897.Dbac_1432	1.586e-41	156.0	COG0745@1|root,COG5002@1|root,COG0745@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,42NK9@68525|delta/epsilon subdivisions,2WMCQ@28221|Deltaproteobacteria,2MH9G@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	5TM-5TMR_LYT,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,SBP_bac_3
REGS1_k127_8833386_6	269799.Gmet_3472	2.368e-66	231.0	COG3437@1|root,COG3437@2|Bacteria,1NW43@1224|Proteobacteria,43007@68525|delta/epsilon subdivisions,2WVGG@28221|Deltaproteobacteria,43UZE@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
REGS1_k127_8833386_0	269799.Gmet_3473	0.0	1124.0	COG2804@1|root,COG3437@1|root,COG2804@2|Bacteria,COG3437@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2WKXB@28221|Deltaproteobacteria,43W1A@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	PFAM type II secretion system protein E	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,T2SSE,T2SSE_N
REGS1_k127_8833386_2	269799.Gmet_3474	9.035e-133	437.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42ZMH@68525|delta/epsilon subdivisions,2WV2I@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
REGS1_k127_8833386_3	243231.GSU2094	8.002e-102	343.0	COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,43C4U@68525|delta/epsilon subdivisions,2WMNA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	metal-dependent phosphohydrolase, HD sub domain	-	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	HD,HD_5,Response_reg
REGS1_k127_8833386_4	269799.Gmet_3475	6.004e-100	331.0	COG1100@1|root,COG1100@2|Bacteria,1RCJJ@1224|Proteobacteria,42R57@68525|delta/epsilon subdivisions,2WN5Y@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Small GTP-binding protein	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	Arf
REGS1_k127_8833386_5	269799.Gmet_3477	7.412e-85	289.0	COG2202@1|root,COG3437@1|root,COG3829@1|root,COG3850@1|root,COG4191@1|root,COG2202@2|Bacteria,COG3437@2|Bacteria,COG3829@2|Bacteria,COG3850@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42PGC@68525|delta/epsilon subdivisions,2WKHK@28221|Deltaproteobacteria,43UFI@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Domains Cache_1, HAMP, PAS, PAS	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_9,dCache_1
REGS1_k127_8833386_1	269799.Gmet_3477	6.101e-140	462.0	COG2202@1|root,COG3437@1|root,COG3829@1|root,COG3850@1|root,COG4191@1|root,COG2202@2|Bacteria,COG3437@2|Bacteria,COG3829@2|Bacteria,COG3850@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42PGC@68525|delta/epsilon subdivisions,2WKHK@28221|Deltaproteobacteria,43UFI@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Domains Cache_1, HAMP, PAS, PAS	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_9,dCache_1
REGS1_k127_8838973_1	289376.THEYE_A0862	1.317e-259	809.0	COG0129@1|root,COG0129@2|Bacteria,3J0ES@40117|Nitrospirae	40117|Nitrospirae	EG	Dehydratase family	ilvD	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
REGS1_k127_8838973_7	335543.Sfum_1233	6.064e-32	128.0	COG0184@1|root,COG0184@2|Bacteria,1MZ2W@1224|Proteobacteria,42TPZ@68525|delta/epsilon subdivisions,2WQ0P@28221|Deltaproteobacteria,2MQJR@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Ribosomal_S15	rpsO	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
REGS1_k127_8838973_0	330214.NIDE4127	2.043e-282	883.0	COG1185@1|root,COG1185@2|Bacteria,3J0DX@40117|Nitrospirae	40117|Nitrospirae	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	-	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
REGS1_k127_8838973_6	1121428.DESHY_80080___1	5.569e-118	392.0	COG0612@1|root,COG0612@2|Bacteria,1TP5I@1239|Firmicutes,248HT@186801|Clostridia,260B8@186807|Peptococcaceae	186801|Clostridia	S	Belongs to the peptidase M16 family	ymxG	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
REGS1_k127_8838973_3	177437.HRM2_11540	5.206e-150	486.0	COG1972@1|root,COG1972@2|Bacteria,1MXXX@1224|Proteobacteria,42PC9@68525|delta/epsilon subdivisions,2WKA4@28221|Deltaproteobacteria,2MJ22@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Na dependent nucleoside transporter	-	-	-	ko:K03317	-	-	-	-	ko00000	2.A.41	-	-	Gate,Nucleos_tra2_C,Nucleos_tra2_N
REGS1_k127_8838973_4	1123376.AUIU01000011_gene930	5.662e-150	486.0	COG1032@1|root,COG1032@2|Bacteria,3J16J@40117|Nitrospirae	40117|Nitrospirae	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
REGS1_k127_8838973_2	1304885.AUEY01000040_gene1611	6.54e-199	634.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2WIPP@28221|Deltaproteobacteria,2MI4H@213118|Desulfobacterales	28221|Deltaproteobacteria	NU	TIGRFAM type IV-A pilus assembly ATPase PilB	epsE	-	-	ko:K02454,ko:K02652	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	T2SSE,T2SSE_N,cNMP_binding
REGS1_k127_8838973_5	1123376.AUIU01000011_gene956	1.035e-148	483.0	COG0166@1|root,COG0166@2|Bacteria,3J174@40117|Nitrospirae	40117|Nitrospirae	G	Phosphoglucose isomerase	pgi	-	5.3.1.9	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI
REGS1_k127_8845210_2	56780.SYN_01341	2.935e-116	382.0	COG0601@1|root,COG0601@2|Bacteria,1NS80@1224|Proteobacteria,42N5D@68525|delta/epsilon subdivisions,2WIRR@28221|Deltaproteobacteria,2MQBC@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
REGS1_k127_8845210_0	56780.SYN_00608	1.307e-216	684.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,42MFK@68525|delta/epsilon subdivisions,2WKBU@28221|Deltaproteobacteria,2MQ6I@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	PFAM Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035,ko:K13893	ko02010,ko02024,map02010,map02024	M00239,M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.21,3.A.1.5.24	-	-	SBP_bac_5
REGS1_k127_8845210_1	391598.FBBAL38_10047	6.38e-178	571.0	COG0178@1|root,COG0178@2|Bacteria,4NFQU@976|Bacteroidetes,1HXMR@117743|Flavobacteriia	976|Bacteroidetes	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA2	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
REGS1_k127_8858102_5	1121441.AUCX01000006_gene964	2.04e-23	111.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MR8@68525|delta/epsilon subdivisions,2WIUA@28221|Deltaproteobacteria,2MA08@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	histidine kinase HAMP region domain protein	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
REGS1_k127_8858102_4	713586.KB900536_gene2038	4.724e-26	114.0	COG0589@1|root,COG0589@2|Bacteria,1NBKV@1224|Proteobacteria,1SHMY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Universal stress protein family	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE,Usp
REGS1_k127_8858102_2	289376.THEYE_A0737	2.769e-48	176.0	2DDIC@1|root,32U1K@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF1634
REGS1_k127_8858102_0	289376.THEYE_A0738	1.765e-141	455.0	COG0730@1|root,COG0730@2|Bacteria	2|Bacteria	S	response to heat	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
REGS1_k127_8858102_3	1382315.JPOI01000001_gene2001	7.213e-32	134.0	COG2188@1|root,COG2188@2|Bacteria,1UYBW@1239|Firmicutes,4HDDG@91061|Bacilli,1WEZR@129337|Geobacillus	91061|Bacilli	K	UTRA	yvoA	-	-	ko:K03710	-	-	-	-	ko00000,ko03000	-	-	-	GntR,UTRA
REGS1_k127_8858102_1	1232410.KI421413_gene501	4.923e-133	454.0	COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,42MN5@68525|delta/epsilon subdivisions,2WINN@28221|Deltaproteobacteria,43SYQ@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism	glnD	-	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	ACT,DUF294,GlnD_UR_UTase,GlnE,HD,NTP_transf_2
REGS1_k127_8872154_11	404589.Anae109_4101	0.0003245	43.0	COG2227@1|root,COG2227@2|Bacteria,1RIMR@1224|Proteobacteria,43CQM@68525|delta/epsilon subdivisions,2X7Y3@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Mycolic acid cyclopropane synthetase	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_8872154_10	370438.PTH_2447	3.42e-06	54.0	COG5304@1|root,COG5304@2|Bacteria,1V6UT@1239|Firmicutes,24JI2@186801|Clostridia,262A3@186807|Peptococcaceae	186801|Clostridia	S	CopG antitoxin of type II toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	CopG_antitoxin
REGS1_k127_8872154_9	1121468.AUBR01000001_gene442	1.944e-19	90.0	COG2929@1|root,COG2929@2|Bacteria,1VBN0@1239|Firmicutes,24N5K@186801|Clostridia,42IIG@68295|Thermoanaerobacterales	186801|Clostridia	S	Ribonuclease toxin, BrnT, of type II toxin-antitoxin system	-	-	-	ko:K09803	-	-	-	-	ko00000	-	-	-	BrnT_toxin
REGS1_k127_8872154_4	909663.KI867150_gene1864	1.006e-69	248.0	28IH6@1|root,2Z8IF@2|Bacteria,1R4Z0@1224|Proteobacteria,42R34@68525|delta/epsilon subdivisions,2WN49@28221|Deltaproteobacteria,2MRQ5@213462|Syntrophobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_8872154_5	1123376.AUIU01000013_gene1711	1.286e-57	207.0	COG0664@1|root,COG0664@2|Bacteria,3J18E@40117|Nitrospirae	40117|Nitrospirae	K	helix_turn_helix, cAMP Regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
REGS1_k127_8872154_8	1121405.dsmv_3328	1.732e-26	113.0	COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,43BSG@68525|delta/epsilon subdivisions,2WM56@28221|Deltaproteobacteria,2MHKW@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM GGDEF domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Response_reg
REGS1_k127_8872154_2	555079.Toce_2222	4.88e-123	404.0	COG2768@1|root,COG2768@2|Bacteria,1TQAW@1239|Firmicutes,247IS@186801|Clostridia,42ETU@68295|Thermoanaerobacterales	186801|Clostridia	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	ko:K07138	-	-	-	-	ko00000	-	-	-	DUF362,Fer4,Fer4_21
REGS1_k127_8872154_6	1047013.AQSP01000140_gene2495	1.648e-50	199.0	COG0501@1|root,COG0501@2|Bacteria	2|Bacteria	O	metalloendopeptidase activity	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
REGS1_k127_8872154_7	521045.Kole_1143	1.943e-47	176.0	COG1704@1|root,COG1704@2|Bacteria,2GCV5@200918|Thermotogae	200918|Thermotogae	S	LemA family	-	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
REGS1_k127_8872154_0	177439.DP0087	8.74e-213	672.0	COG0318@1|root,COG0318@2|Bacteria,1QVGC@1224|Proteobacteria,43BUA@68525|delta/epsilon subdivisions	1224|Proteobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	2.3.1.40,6.2.1.20	ko:K05939	ko00071,ko00564,map00071,map00564	-	R01406,R04864	RC00014,RC00039,RC00041	ko00000,ko00001,ko01000	-	-	-	AMP-binding
REGS1_k127_8872154_1	1232410.KI421417_gene2727	1.221e-138	454.0	COG2067@1|root,COG2067@2|Bacteria,1MUU4@1224|Proteobacteria,42N9J@68525|delta/epsilon subdivisions,2X2B8@28221|Deltaproteobacteria,43U8G@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	Outer membrane protein transport protein (OMPP1/FadL/TodX)	-	-	-	-	-	-	-	-	-	-	-	-	Toluene_X
REGS1_k127_8872154_3	289376.THEYE_A0454	3.953e-100	332.0	COG0313@1|root,COG0313@2|Bacteria,3J0PU@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	-	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
REGS1_k127_8874035_0	1167006.UWK_02855	3.886e-142	461.0	COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42N46@68525|delta/epsilon subdivisions,2WJT4@28221|Deltaproteobacteria,2MPMZ@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,PocR,Response_reg
REGS1_k127_8874035_1	1123487.KB892837_gene4027	9.336e-18	88.0	COG0784@1|root,COG0784@2|Bacteria,1QUN7@1224|Proteobacteria,2WGQ0@28216|Betaproteobacteria,2KWBX@206389|Rhodocyclales	206389|Rhodocyclales	T	response regulator	-	-	-	ko:K02485	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg
REGS1_k127_8874035_2	1232410.KI421421_gene3342	3.064e-10	61.0	COG4251@1|root,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_9
REGS1_k127_8879692_4	443143.GM18_2451	1.207e-24	110.0	COG1436@1|root,COG1436@2|Bacteria	2|Bacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpF	-	-	ko:K02122	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_F
REGS1_k127_8879692_1	1041930.Mtc_2334	3.023e-180	582.0	COG1155@1|root,arCOG00868@2157|Archaea,2XT8I@28890|Euryarchaeota,2NANC@224756|Methanomicrobia	224756|Methanomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit	atpA-2	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
REGS1_k127_8879692_0	443143.GM18_2453	2.153e-206	650.0	COG1156@1|root,COG1156@2|Bacteria,1R4RB@1224|Proteobacteria,42PJC@68525|delta/epsilon subdivisions,2WJB9@28221|Deltaproteobacteria,43SZ6@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	ATP synthase alpha/beta family, nucleotide-binding domain	-	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
REGS1_k127_8879692_2	443143.GM18_2454	1.194e-65	230.0	COG1394@1|root,COG1394@2|Bacteria,1PA1A@1224|Proteobacteria,42VQ3@68525|delta/epsilon subdivisions,2WT1Q@28221|Deltaproteobacteria,43VWT@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	ATP synthase subunit D	-	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
REGS1_k127_8879692_6	747365.Thena_1035	6.471e-12	72.0	COG0607@1|root,305HX@2|Bacteria,1VPPG@1239|Firmicutes,24V0S@186801|Clostridia	186801|Clostridia	P	Protein of unknown function (DUF2892)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2892
REGS1_k127_8879692_5	1461580.CCAS010000003_gene484	1.731e-13	74.0	COG0348@1|root,COG0348@2|Bacteria,1TPHF@1239|Firmicutes,4IJZ2@91061|Bacilli,1ZEQZ@1386|Bacillus	91061|Bacilli	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_10,Fer4_5
REGS1_k127_8887809_2	671143.DAMO_1249	2.011e-99	340.0	COG1615@1|root,COG1615@2|Bacteria,2NQSF@2323|unclassified Bacteria	2|Bacteria	S	Uncharacterised protein family (UPF0182)	-	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K09118	-	-	-	-	ko00000	-	-	-	UPF0182
REGS1_k127_8887809_0	243231.GSU0913	1.077e-230	730.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,42MMK@68525|delta/epsilon subdivisions,2WJC1@28221|Deltaproteobacteria,43T4P@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	ABC transporter C-terminal domain	uup	-	-	ko:K15738	-	-	-	-	ko00000,ko02000	3.A.1.120.6	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
REGS1_k127_8887809_5	909663.KI867151_gene3027	1.124e-25	107.0	COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,42V0K@68525|delta/epsilon subdivisions,2WR92@28221|Deltaproteobacteria,2MS84@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	SMART Cold shock protein	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
REGS1_k127_8887809_3	243231.GSU0802	2.56e-75	259.0	COG1028@1|root,COG1028@2|Bacteria,1RBGC@1224|Proteobacteria,42TP6@68525|delta/epsilon subdivisions,2WQAU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
REGS1_k127_8887809_1	552811.Dehly_0886	5.262e-123	408.0	COG1249@1|root,COG1249@2|Bacteria,2G5MR@200795|Chloroflexi,34DQQ@301297|Dehalococcoidia	200795|Chloroflexi	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	lpd	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
REGS1_k127_8887809_4	247490.KSU1_D0399	7.026e-47	175.0	COG2095@1|root,COG2095@2|Bacteria,2J0YY@203682|Planctomycetes	203682|Planctomycetes	U	MarC family integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	MarC
REGS1_k127_8891755_0	269799.Gmet_2510	4.039e-153	488.0	COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,42N06@68525|delta/epsilon subdivisions,2WK5N@28221|Deltaproteobacteria,43T7Z@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Transketolase, pyrimidine binding domain	bkdB	-	1.2.4.1,1.2.4.4	ko:K00162,ko:K00167	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
REGS1_k127_8891755_2	243231.GSU2654	1.065e-138	449.0	COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,42NW8@68525|delta/epsilon subdivisions,2WJY1@28221|Deltaproteobacteria,43UJJ@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Dehydrogenase E1 component	bkdA	-	1.2.4.1,1.2.4.4	ko:K00161,ko:K00166	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
REGS1_k127_8891755_1	404380.Gbem_2779	3.014e-152	492.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,42MGZ@68525|delta/epsilon subdivisions,2WIY6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Belongs to the DEAD box helicase family	rhlB	-	3.6.4.13	ko:K03732	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03019	-	-	-	DEAD,Helicase_C,R3H
REGS1_k127_8908048_0	933262.AXAM01000004_gene2384	4.415e-196	619.0	COG0126@1|root,COG0126@2|Bacteria,1R5QA@1224|Proteobacteria,42MED@68525|delta/epsilon subdivisions,2WMKU@28221|Deltaproteobacteria,2MMXE@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Phosphoglycerate kinase	-	-	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
REGS1_k127_8908048_1	324925.Ppha_0717	3.934e-170	542.0	COG0205@1|root,COG0205@2|Bacteria,1FEH2@1090|Chlorobi	1090|Chlorobi	G	PFAM phosphofructokinase	-	-	2.7.1.11	ko:K00850	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
REGS1_k127_891038_1	289376.THEYE_A0155	1.024e-131	430.0	COG0337@1|root,COG0337@2|Bacteria,3J0GA@40117|Nitrospirae	40117|Nitrospirae	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	4.2.3.4	ko:K01735	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03083	RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase
REGS1_k127_891038_3	1123376.AUIU01000011_gene1075	2.51e-46	173.0	COG0703@1|root,COG0703@2|Bacteria,3J0R8@40117|Nitrospirae	40117|Nitrospirae	F	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	aroK	GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	SKI
REGS1_k127_891038_0	289376.THEYE_A0624	3.296e-143	465.0	COG0082@1|root,COG0082@2|Bacteria,3J0KQ@40117|Nitrospirae	40117|Nitrospirae	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	-	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
REGS1_k127_891038_2	118163.Ple7327_4539	4.943e-110	377.0	COG0823@1|root,COG1404@1|root,COG2931@1|root,COG0823@2|Bacteria,COG1404@2|Bacteria,COG2931@2|Bacteria,1GJ0J@1117|Cyanobacteria,3VIZ2@52604|Pleurocapsales	1117|Cyanobacteria	QU	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	CBM_6,SdrD_B
REGS1_k127_8916944_2	289376.THEYE_A1800	7.992e-74	256.0	COG0325@1|root,COG0325@2|Bacteria,3J0RJ@40117|Nitrospirae	40117|Nitrospirae	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis	-	-	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
REGS1_k127_8916944_1	289376.THEYE_A1799	1.333e-76	265.0	COG0345@1|root,COG0345@2|Bacteria,3J0N8@40117|Nitrospirae	40117|Nitrospirae	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	-	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_oxidored,P5CR_dimer
REGS1_k127_8916944_4	289376.THEYE_A1798	1.969e-34	135.0	COG0762@1|root,COG0762@2|Bacteria,3J0U5@40117|Nitrospirae	40117|Nitrospirae	S	YGGT family	-	-	-	ko:K02221	-	-	-	-	ko00000,ko02044	-	-	-	YGGT
REGS1_k127_8916944_3	289376.THEYE_A1797	4.358e-61	214.0	COG3599@1|root,COG3599@2|Bacteria,3J19M@40117|Nitrospirae	40117|Nitrospirae	D	DivIVA protein	-	-	-	ko:K04074	-	-	-	-	ko00000,ko03036	-	-	-	DivIVA
REGS1_k127_8916944_0	289376.THEYE_A1796	5.235e-132	430.0	COG0124@1|root,COG0124@2|Bacteria,3J0EC@40117|Nitrospirae	40117|Nitrospirae	J	Histidyl-tRNA synthetase	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
REGS1_k127_8939743_0	1121918.ARWE01000001_gene3201	1.838e-118	411.0	COG0745@1|root,COG4191@1|root,COG0745@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,43BT2@68525|delta/epsilon subdivisions,2WM4H@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4,Response_reg
REGS1_k127_89471_2	867845.KI911784_gene2048	7.459e-13	69.0	COG0193@1|root,COG0193@2|Bacteria,2G6SW@200795|Chloroflexi,375JU@32061|Chloroflexia	32061|Chloroflexia	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	GO:0003674,GO:0003824,GO:0004045,GO:0016787,GO:0016788,GO:0052689,GO:0140098,GO:0140101	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
REGS1_k127_89471_1	289376.THEYE_A1454	3.233e-56	203.0	COG1825@1|root,COG1825@2|Bacteria,3J0NK@40117|Nitrospirae	40117|Nitrospirae	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
REGS1_k127_89471_0	289376.THEYE_A1455	2.376e-133	431.0	COG0462@1|root,COG0462@2|Bacteria,3J0D0@40117|Nitrospirae	40117|Nitrospirae	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
REGS1_k127_89471_3	290512.Paes_1591	1.017e-07	57.0	COG1947@1|root,COG1947@2|Bacteria,1FDN3@1090|Chlorobi	1090|Chlorobi	F	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	ispE	-	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
REGS1_k127_8992662_1	1123376.AUIU01000012_gene1514	9.169e-106	349.0	COG0294@1|root,COG0294@2|Bacteria,3J0NS@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	folP	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
REGS1_k127_8992662_0	1123376.AUIU01000012_gene1515	2.51e-287	890.0	COG0465@1|root,COG0465@2|Bacteria,3J0AG@40117|Nitrospirae	40117|Nitrospirae	D	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
REGS1_k127_9014840_3	1123376.AUIU01000002_gene1676	7.505e-33	128.0	COG0034@1|root,COG0034@2|Bacteria,3J0C5@40117|Nitrospirae	40117|Nitrospirae	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_7,Pribosyltran
REGS1_k127_9014840_1	289376.THEYE_A1195	1.409e-119	395.0	COG2309@1|root,COG2309@2|Bacteria	2|Bacteria	E	aminopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M29
REGS1_k127_9014840_4	1123376.AUIU01000013_gene1907	2.057e-32	128.0	COG1324@1|root,COG1324@2|Bacteria,3J0UM@40117|Nitrospirae	40117|Nitrospirae	P	CutA1 divalent ion tolerance protein	cutA	-	-	ko:K03926	-	-	-	-	ko00000	-	-	-	CutA1
REGS1_k127_9014840_2	589865.DaAHT2_0405	1.916e-76	267.0	COG3221@1|root,COG3221@2|Bacteria,1MXD8@1224|Proteobacteria,42UZB@68525|delta/epsilon subdivisions,2WQSS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	ABC transporter, phosphonate, periplasmic substrate-binding protein	-	-	-	ko:K02044	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	Phosphonate-bd
REGS1_k127_9014840_0	289376.THEYE_A2000	6.524e-244	765.0	COG0272@1|root,COG0272@2|Bacteria,3J0W8@40117|Nitrospirae	40117|Nitrospirae	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
REGS1_k127_905790_1	555779.Dthio_PD3236	2.993e-162	514.0	COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,42N6N@68525|delta/epsilon subdivisions,2WJ1W@28221|Deltaproteobacteria,2M833@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM Respiratory-chain NADH dehydrogenase domain 51 kDa subunit	-	-	1.6.5.3	ko:K00124,ko:K00335	ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200	M00144	R00519,R11945	RC00061,RC02796	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
REGS1_k127_905790_2	555779.Dthio_PD3234	1.343e-49	187.0	COG1894@1|root,COG1894@2|Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	-	-	-	-	-	-	-	-	-	-	-	-	Fe_hyd_SSU,Fe_hyd_lg_C,Fer4,SLBB
REGS1_k127_905790_0	555779.Dthio_PD3233	1.187e-222	708.0	COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,43D31@68525|delta/epsilon subdivisions	1224|Proteobacteria	C	NADH ubiquinone oxidoreductase, subunit G, iron-sulphur binding	nuoG2	-	1.12.7.2,1.17.1.10,1.17.1.9,1.6.5.3	ko:K00123,ko:K00336,ko:K05299,ko:K06441	ko00190,ko00630,ko00680,ko00720,ko01100,ko01120,ko01200,map00190,map00630,map00680,map00720,map01100,map01120,map01200	M00144,M00377	R00019,R00134,R00519,R11945	RC00061,RC02796	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,Fer4_10,Fer4_7,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
REGS1_k127_9062610_4	335543.Sfum_2453	3.047e-71	258.0	COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,1PFBF@1224|Proteobacteria,42RAR@68525|delta/epsilon subdivisions,2WN52@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Protein phosphatase 2C domain	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	GAF,GAF_2,SpoIIE
REGS1_k127_9062610_7	335543.Sfum_2452	2.719e-25	110.0	COG2172@1|root,COG2172@2|Bacteria,1N9EJ@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase-like ATPase domain	-	-	2.7.11.1	ko:K04757	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	HATPase_c_2
REGS1_k127_9062610_9	497964.CfE428DRAFT_5327	7.736e-22	98.0	COG1366@1|root,COG1366@2|Bacteria	2|Bacteria	T	antisigma factor binding	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS,STAS_2
REGS1_k127_9062610_3	1499967.BAYZ01000135_gene84	1.185e-78	271.0	COG0767@1|root,COG0767@2|Bacteria,2NPFZ@2323|unclassified Bacteria	2|Bacteria	Q	ABC-type transport system involved in resistance to organic solvents permease component	mlaE_1	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE,STAS_2
REGS1_k127_9062610_1	1499967.BAYZ01000135_gene85	3.815e-91	306.0	COG1127@1|root,COG1127@2|Bacteria,2NP3U@2323|unclassified Bacteria	2|Bacteria	Q	ABC-type transport system involved in resistance to organic solvents, ATPase component	ttg2A	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
REGS1_k127_9062610_8	207559.Dde_0021	3.003e-25	116.0	COG1463@1|root,COG1463@2|Bacteria,1MU4B@1224|Proteobacteria,42RPB@68525|delta/epsilon subdivisions,2WSF2@28221|Deltaproteobacteria,2M8KX@213115|Desulfovibrionales	28221|Deltaproteobacteria	Q	PFAM Mammalian cell entry related	-	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
REGS1_k127_9062610_10	1033802.SSPSH_003350	2.296e-07	60.0	COG3009@1|root,COG3009@2|Bacteria,1PJIN@1224|Proteobacteria,1RQTB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	protein conserved in bacteria	ymbA	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030288,GO:0030312,GO:0030313,GO:0031224,GO:0031225,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0036405,GO:0036406,GO:0042597,GO:0042802,GO:0044425,GO:0044462,GO:0044464,GO:0071944,GO:0098552	-	ko:K09857	-	-	-	-	ko00000	-	-	-	ABC_trans_aux
REGS1_k127_9062610_6	694431.DESACE_00770	2.362e-47	177.0	COG1280@1|root,COG1280@2|Bacteria,1QT7A@1224|Proteobacteria,43438@68525|delta/epsilon subdivisions,2X50X@28221|Deltaproteobacteria,2M7N4@213113|Desulfurellales	28221|Deltaproteobacteria	E	SPTR Lysine exporter protein (LYSE YGGA)	-	-	-	-	-	-	-	-	-	-	-	-	LysE
REGS1_k127_9062610_2	375286.mma_1560	5.314e-80	280.0	COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,2VI41@28216|Betaproteobacteria,47327@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Phospholipase D. Active site motifs.	cls	-	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2,PLDc_N
REGS1_k127_9062610_0	443143.GM18_2592	3.459e-120	402.0	COG0260@1|root,COG0260@2|Bacteria,1MUF9@1224|Proteobacteria,42M2G@68525|delta/epsilon subdivisions,2WJ80@28221|Deltaproteobacteria,43RYN@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
REGS1_k127_9062610_5	1123376.AUIU01000016_gene330	1.571e-47	179.0	28Q1P@1|root,2ZCJY@2|Bacteria	2|Bacteria	S	Zinc dependent phospholipase C	-	-	-	-	-	-	-	-	-	-	-	-	Zn_dep_PLPC
REGS1_k127_9073132_1	1232410.KI421418_gene2367	1.652e-50	191.0	COG2199@1|root,COG2203@1|root,COG2203@2|Bacteria,COG3706@2|Bacteria,1NECV@1224|Proteobacteria,42PZK@68525|delta/epsilon subdivisions,2WMIG@28221|Deltaproteobacteria,43W33@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GGDEF
REGS1_k127_9073132_0	289376.THEYE_A1045	4.118e-110	360.0	COG1013@1|root,COG1013@2|Bacteria	2|Bacteria	C	oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
REGS1_k127_9073132_2	289376.THEYE_A1044	1.007e-41	156.0	COG1014@1|root,COG1014@2|Bacteria	2|Bacteria	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	porG	-	1.2.7.3,1.2.7.7	ko:K00177,ko:K00187	ko00020,ko00280,ko00720,ko01100,ko01120,ko01200,map00020,map00280,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197,R07160,R08566,R08567	RC00004,RC02833,RC02856	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
REGS1_k127_9115466_3	1123376.AUIU01000015_gene462	1.504e-28	117.0	COG1729@1|root,COG1729@2|Bacteria,3J0RE@40117|Nitrospirae	40117|Nitrospirae	S	Outer membrane lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_6
REGS1_k127_9115466_0	289376.THEYE_A2096	1.035e-105	353.0	COG2896@1|root,COG2896@2|Bacteria,3J0PB@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_14,Mob_synth_C,Radical_SAM
REGS1_k127_9115466_1	370438.PTH_2609	1.578e-58	208.0	COG0315@1|root,COG0315@2|Bacteria,1V3J4@1239|Firmicutes,24H9F@186801|Clostridia,261ZC@186807|Peptococcaceae	186801|Clostridia	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
REGS1_k127_9115466_2	316067.Geob_1852	2.878e-52	190.0	COG1418@1|root,COG1418@2|Bacteria,1RK7K@1224|Proteobacteria,42SRK@68525|delta/epsilon subdivisions,2WP5I@28221|Deltaproteobacteria,43UQH@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Metal-dependent phosphohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HD
REGS1_k127_9131935_2	316067.Geob_1378	4.019e-85	292.0	COG4786@1|root,COG4786@2|Bacteria,1MZXB@1224|Proteobacteria,42MTK@68525|delta/epsilon subdivisions,2WM8U@28221|Deltaproteobacteria	28221|Deltaproteobacteria	N	Protein of unknown function (DUF2950)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2950
REGS1_k127_9131935_3	316067.Geob_1379	1.677e-71	257.0	COG3115@1|root,COG3115@2|Bacteria,1QVM5@1224|Proteobacteria,43CDH@68525|delta/epsilon subdivisions,2X7PC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	D	Protein of unknown function (DUF3300)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3300
REGS1_k127_9131935_1	247490.KSU1_A0025	1.084e-95	329.0	COG0773@1|root,COG0773@2|Bacteria,2J20J@203682|Planctomycetes	203682|Planctomycetes	M	Mur ligase family, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
REGS1_k127_9131935_6	1479238.JQMZ01000001_gene596	0.0001169	54.0	COG4567@1|root,COG4567@2|Bacteria,1RD7J@1224|Proteobacteria,2TSK7@28211|Alphaproteobacteria,43WQ4@69657|Hyphomonadaceae	28211|Alphaproteobacteria	KT	COG4567 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain	regA	GO:0000156,GO:0000160,GO:0003674,GO:0007154,GO:0007165,GO:0008150,GO:0009987,GO:0023052,GO:0035556,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060089,GO:0065007	-	ko:K15012	ko02020,map02020	M00523	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg
REGS1_k127_9131935_0	635013.TherJR_1894	8.995e-134	440.0	COG0826@1|root,COG0826@2|Bacteria,1TPRE@1239|Firmicutes,248I3@186801|Clostridia,260QK@186807|Peptococcaceae	186801|Clostridia	O	PFAM peptidase	yhbU_1	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_U32,Peptidase_U32_C
REGS1_k127_9131935_5	443144.GM21_1764	6.346e-57	203.0	COG0328@1|root,COG0328@2|Bacteria,1RCZ1@1224|Proteobacteria,42SIR@68525|delta/epsilon subdivisions,2WPJY@28221|Deltaproteobacteria,43V2X@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhA	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576	3.1.26.4	ko:K03469	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_H
REGS1_k127_9170922_2	1041930.Mtc_0697	3.124e-91	310.0	COG0715@1|root,arCOG01803@2157|Archaea,2XWEK@28890|Euryarchaeota,2NAA1@224756|Methanomicrobia	224756|Methanomicrobia	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1_2
REGS1_k127_9170922_0	243231.GSU2303	1.769e-164	525.0	COG3004@1|root,COG3004@2|Bacteria,1MW15@1224|Proteobacteria,42MBN@68525|delta/epsilon subdivisions,2WMH2@28221|Deltaproteobacteria,43TI5@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	) H( ) antiporter that extrudes sodium in exchange for external protons	nhaA	GO:0003674,GO:0005215,GO:0005451,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015081,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015318,GO:0015385,GO:0015491,GO:0015672,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0035725,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0098655,GO:0098660,GO:0098662,GO:0099516,GO:1902600	-	ko:K03313	-	-	-	-	ko00000,ko02000	2.A.33.1	-	-	Na_H_antiport_1
REGS1_k127_9170922_3	1163617.SCD_n02027	1.625e-64	230.0	COG3260@1|root,COG3260@2|Bacteria,1QUBE@1224|Proteobacteria,2VP8A@28216|Betaproteobacteria	28216|Betaproteobacteria	C	NADH ubiquinone oxidoreductase 20 kDa subunit	hyfI	-	-	-	-	-	-	-	-	-	-	-	Oxidored_q6
REGS1_k127_9170922_1	314345.SPV1_04533	4.218e-106	353.0	COG3261@1|root,COG3261@2|Bacteria,1QUBF@1224|Proteobacteria	1224|Proteobacteria	C	NADH dehydrogenase	hyfG	-	-	-	-	-	-	-	-	-	-	-	Complex1_30kDa,Complex1_49kDa,NiFeSe_Hases
REGS1_k127_9185167_0	289376.THEYE_A0131	0.0	1026.0	COG0209@1|root,COG0209@2|Bacteria,3J0MG@40117|Nitrospirae	40117|Nitrospirae	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_lgC,Ribonuc_red_lgN,TSCPD
REGS1_k127_9185167_1	671143.DAMO_0826	5.454e-49	188.0	COG3005@1|root,COG3005@2|Bacteria	2|Bacteria	C	denitrification pathway	-	-	-	ko:K02569,ko:K15876	ko00910,ko01120,map00910,map01120	M00530	R05712	RC00176	ko00000,ko00001,ko00002	-	-	-	Cytochrom_NNT,Cytochrome_C7
REGS1_k127_9185167_2	1157490.EL26_22495	1.422e-09	62.0	COG3027@1|root,COG3027@2|Bacteria,1VFZR@1239|Firmicutes,4HNRI@91061|Bacilli,278K2@186823|Alicyclobacillaceae	91061|Bacilli	D	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division	zapA	-	-	ko:K09888	-	-	-	-	ko00000,ko03036	-	-	-	ZapA
REGS1_k127_9195574_2	1122947.FR7_3309	4.431e-97	327.0	COG0331@1|root,COG0331@2|Bacteria,1TPB7@1239|Firmicutes,4H21S@909932|Negativicutes	909932|Negativicutes	I	malonyl CoA-acyl carrier protein transacylase	fabD	-	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
REGS1_k127_9195574_1	1123376.AUIU01000004_gene1162	5.479e-154	496.0	COG2025@1|root,COG2025@2|Bacteria	2|Bacteria	C	fatty acid beta-oxidation using acyl-CoA dehydrogenase	fixB	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006091,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009055,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0019395,GO:0019752,GO:0022900,GO:0030258,GO:0032787,GO:0033539,GO:0034440,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071704,GO:0072329,GO:0097159,GO:1901265,GO:1901363,GO:1901575	1.3.1.108	ko:K03522,ko:K22432	-	-	-	-	ko00000,ko01000,ko04147	-	-	iAF987.Gmet_2066,iAF987.Gmet_2257	ETF,ETF_alpha,Fer4
REGS1_k127_9195574_3	1121403.AUCV01000002_gene511	3.253e-93	312.0	COG2086@1|root,COG2086@2|Bacteria,1MVH6@1224|Proteobacteria,42RCI@68525|delta/epsilon subdivisions,2WM55@28221|Deltaproteobacteria,2MPY6@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Electron transfer flavoprotein	-	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
REGS1_k127_9195574_0	289376.THEYE_A0567	2.274e-161	511.0	COG1960@1|root,COG1960@2|Bacteria,3J13U@40117|Nitrospirae	40117|Nitrospirae	C	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
REGS1_k127_9195902_0	335543.Sfum_0727	2.013e-185	588.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,42MFT@68525|delta/epsilon subdivisions,2WIXC@28221|Deltaproteobacteria,2MRAX@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	Ammonium Transporter Family	amtB	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
REGS1_k127_9195902_4	269799.Gmet_2817	3.797e-67	243.0	COG2206@1|root,COG2206@2|Bacteria,1RE2G@1224|Proteobacteria,42S6Z@68525|delta/epsilon subdivisions,2WNCP@28221|Deltaproteobacteria,43TC7@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	cyclic diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	HD
REGS1_k127_9195902_3	269799.Gmet_2816	2.044e-77	286.0	COG1413@1|root,COG1413@2|Bacteria,1N5TU@1224|Proteobacteria,42UDF@68525|delta/epsilon subdivisions,2WQ3K@28221|Deltaproteobacteria,43TQ4@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
REGS1_k127_9195902_5	1123371.ATXH01000015_gene1639	9.213e-65	236.0	COG0436@1|root,COG0436@2|Bacteria,2GHA1@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	E	DegT/DnrJ/EryC1/StrS aminotransferase family	-	-	2.6.1.2,2.6.1.66	ko:K14260	ko00220,ko00250,ko00290,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00290,map01100,map01110,map01130,map01210,map01230	-	R00258,R01215	RC00006,RC00008,RC00036	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
REGS1_k127_9195902_6	1231190.NA8A_20777	1.57e-18	95.0	COG0234@1|root,COG0234@2|Bacteria,1MZ2X@1224|Proteobacteria,2U9AQ@28211|Alphaproteobacteria,43PFA@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	-	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
REGS1_k127_9195902_1	572477.Alvin_1047	2.789e-123	407.0	COG1449@1|root,COG1449@2|Bacteria,1R5KI@1224|Proteobacteria,1S0ID@1236|Gammaproteobacteria,1WXJ4@135613|Chromatiales	135613|Chromatiales	G	Belongs to the glycosyl hydrolase 57 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_57
REGS1_k127_9195902_2	1232683.ADIMK_1782	8.348e-80	274.0	COG0564@1|root,COG0564@2|Bacteria,1R4IN@1224|Proteobacteria,1S0WR@1236|Gammaproteobacteria,466SG@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	COG0564 Pseudouridylate synthases, 23S RNA-specific	-	-	5.4.99.28,5.4.99.29	ko:K06177	-	-	-	-	ko00000,ko01000,ko03009,ko03016	-	-	-	PseudoU_synth_2
REGS1_k127_9195902_7	1232410.KI421415_gene3082	5.853e-16	78.0	COG1193@1|root,COG1193@2|Bacteria,1NCS6@1224|Proteobacteria,42VGJ@68525|delta/epsilon subdivisions,2WRA6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM Smr protein MutS2	-	-	-	-	-	-	-	-	-	-	-	-	Smr
REGS1_k127_9215338_6	269799.Gmet_0979	4.887e-22	108.0	COG0457@1|root,COG0457@2|Bacteria,1NEMW@1224|Proteobacteria,42WBX@68525|delta/epsilon subdivisions,2WRAD@28221|Deltaproteobacteria,43VAR@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_14,TPR_16,TPR_19,TPR_8
REGS1_k127_9215338_7	1242864.D187_006593	4.248e-18	88.0	COG2018@1|root,COG2018@2|Bacteria,1NG1T@1224|Proteobacteria,42VP4@68525|delta/epsilon subdivisions,2WS9A@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Roadblock/LC7 domain	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_9215338_4	398767.Glov_1595	2.361e-48	178.0	COG0757@1|root,COG0757@2|Bacteria,1RDDT@1224|Proteobacteria,42QU1@68525|delta/epsilon subdivisions,2WP6E@28221|Deltaproteobacteria,43SNK@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Catalyzes a trans-dehydration via an enolate intermediate	aroQ	-	4.2.1.10	ko:K03786	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_II
REGS1_k127_9215338_2	289376.THEYE_A0401	1.38e-82	287.0	COG0006@1|root,COG0006@2|Bacteria,3J0R0@40117|Nitrospirae	40117|Nitrospirae	E	Metallopeptidase family M24	-	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
REGS1_k127_9215338_3	880072.Desac_1365	2.029e-70	242.0	COG0231@1|root,COG0231@2|Bacteria,1MW2J@1224|Proteobacteria,42N6H@68525|delta/epsilon subdivisions,2WNG7@28221|Deltaproteobacteria,2MRIC@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	efp	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
REGS1_k127_9215338_5	1123376.AUIU01000013_gene1763	7.47e-48	175.0	COG0511@1|root,COG0511@2|Bacteria,3J0PI@40117|Nitrospirae	40117|Nitrospirae	I	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA	accB	-	-	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742	RC00040,RC00367	ko00000,ko00001,ko00002	-	-	-	Biotin_lipoyl
REGS1_k127_9215338_0	289376.THEYE_A0398	6.309e-210	660.0	COG0439@1|root,COG0439@2|Bacteria,3J0AJ@40117|Nitrospirae	40117|Nitrospirae	I	Biotin carboxylase C-terminal domain	-	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
REGS1_k127_9215338_8	1454202.PPBDW_80280___1	4.384e-06	53.0	COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,1RN3Z@1236|Gammaproteobacteria,1XSBC@135623|Vibrionales	135623|Vibrionales	U	COG4796 Type II secretory pathway, component HofQ	pilQ	-	-	ko:K02666	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	STN,Secretin,Secretin_N
REGS1_k127_9215338_1	1167006.UWK_02855	4.093e-171	567.0	COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42N46@68525|delta/epsilon subdivisions,2WJT4@28221|Deltaproteobacteria,2MPMZ@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,PocR,Response_reg
REGS1_k127_926693_1	1167006.UWK_01429	2.723e-93	342.0	COG2199@1|root,COG3221@1|root,COG3437@1|root,COG4191@1|root,COG2199@2|Bacteria,COG3221@2|Bacteria,COG3437@2|Bacteria,COG4191@2|Bacteria,1MUB8@1224|Proteobacteria,43C4U@68525|delta/epsilon subdivisions,2WMNA@28221|Deltaproteobacteria,2MPN7@213118|Desulfobacterales	28221|Deltaproteobacteria	KT	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GGDEF,HD
REGS1_k127_926693_0	335543.Sfum_3519	5.604e-136	472.0	COG2204@1|root,COG4191@1|root,COG2204@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42N46@68525|delta/epsilon subdivisions,2WJT4@28221|Deltaproteobacteria,2MQX0@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4,Response_reg
REGS1_k127_951591_1	694427.Palpr_1681	1.357e-106	350.0	COG0119@1|root,COG0119@2|Bacteria,4NHR2@976|Bacteroidetes,2FRGF@200643|Bacteroidia,22YPQ@171551|Porphyromonadaceae	976|Bacteroidetes	E	HMGL-like	-	-	4.1.3.39	ko:K01666	ko00360,ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00360,map00362,map00621,map00622,map01100,map01120,map01220	M00545,M00569	R00750	RC00307,RC00371	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	DmpG_comm,HMGL-like
REGS1_k127_951591_2	1434325.AZQN01000003_gene2373	4.814e-45	173.0	COG0800@1|root,COG0800@2|Bacteria,4NNYN@976|Bacteroidetes,47XPW@768503|Cytophagia	976|Bacteroidetes	G	KDPG and KHG aldolase	-	-	4.1.2.14,4.1.3.42	ko:K01625	ko00030,ko00630,ko01100,ko01120,ko01200,map00030,map00630,map01100,map01120,map01200	M00008,M00061,M00308,M00631	R00470,R05605	RC00307,RC00308,RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase
REGS1_k127_951591_0	1237149.C900_04358	1.753e-200	642.0	COG1001@1|root,COG1001@2|Bacteria,4NFD9@976|Bacteroidetes,47KX0@768503|Cytophagia	976|Bacteroidetes	F	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family	ade	-	3.5.4.2	ko:K01486	ko00230,ko01100,map00230,map01100	-	R01244	RC00477	ko00000,ko00001,ko01000	-	-	-	Adenine_deam_C,Amidohydro_1
REGS1_k127_963861_0	335543.Sfum_1103	1.735e-98	331.0	COG1122@1|root,COG1122@2|Bacteria,1N5X0@1224|Proteobacteria,43ADF@68525|delta/epsilon subdivisions,2WMEV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	part of an ABC transporter complex. Responsible for energy coupling to the transport system	-	-	-	ko:K02006,ko:K16787	ko02010,map02010	M00245,M00246,M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.18,3.A.1.22,3.A.1.23,3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran
REGS1_k127_963861_1	289376.THEYE_A0788	3.038e-55	198.0	COG0494@1|root,COG0494@2|Bacteria,3J0TN@40117|Nitrospirae	40117|Nitrospirae	L	NUDIX domain	-	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
REGS1_k127_963861_2	935863.AWZR01000014_gene2935	3.529e-38	151.0	COG1285@1|root,COG1285@2|Bacteria,1MURJ@1224|Proteobacteria,1RQUD@1236|Gammaproteobacteria,1X84Y@135614|Xanthomonadales	135614|Xanthomonadales	S	MgtC family	-	-	-	ko:K07507	-	-	-	-	ko00000,ko02000	9.B.20	-	-	MgtC
REGS1_k127_986640_1	1219084.AP014508_gene19	2.588e-56	202.0	COG3653@1|root,COG3653@2|Bacteria	2|Bacteria	Q	N-Acyl-D-aspartate D-glutamate deacylase	-	-	3.5.1.81	ko:K06015	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Amidohydro_3
REGS1_k127_986640_4	293826.Amet_4445	5.877e-15	83.0	COG0619@1|root,COG0619@2|Bacteria,1TQ0E@1239|Firmicutes,248AB@186801|Clostridia,36FFB@31979|Clostridiaceae	186801|Clostridia	P	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates	ecfT	-	-	ko:K16783,ko:K16785	ko02010,map02010	M00581,M00582	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.25,3.A.1.25.1,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	CbiQ
REGS1_k127_986640_0	289376.THEYE_A1467	1.058e-101	344.0	COG0860@1|root,COG0860@2|Bacteria,3J0MT@40117|Nitrospirae	40117|Nitrospirae	M	Ami_3	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	AMIN,Amidase_3
REGS1_k127_986640_3	289376.THEYE_A1468	2.062e-23	101.0	COG0694@1|root,COG0694@2|Bacteria	2|Bacteria	O	iron-sulfur cluster assembly	yutI	-	-	-	-	-	-	-	-	-	-	-	NifU
REGS1_k127_986640_2	484770.UFO1_1572	4.508e-24	110.0	COG3852@1|root,COG3852@2|Bacteria,1TRH0@1239|Firmicutes,4H3PA@909932|Negativicutes	909932|Negativicutes	T	SMART ATP-binding region ATPase domain protein, histidine kinase A domain protein	-	-	2.7.13.3	ko:K07710	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS
## 2341 queries scanned
## Total time (seconds): 303.0087938308716
## Rate: 7.73 q/s