## Mon Nov 11 23:30:53 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/4635/R/REGS1_bin.27.fa -m mmseqs --itype genome -o REGS1_bin.27 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/bins_4635/REGS1_bin.27 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
REGS1_k127_1000916_0	926550.CLDAP_06400	6.612e-291	908.0	COG3383@1|root,COG3383@2|Bacteria,2GBH3@200795|Chloroflexi	200795|Chloroflexi	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Fer4,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
REGS1_k127_100139_0	926550.CLDAP_07440	4.245e-14	85.0	COG4713@1|root,COG4713@2|Bacteria	2|Bacteria	M	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	DUF2142
REGS1_k127_1001499_0	1123488.ATUF01000004_gene1607	1.091e-23	100.0	COG0178@1|root,COG0178@2|Bacteria,2GJUV@201174|Actinobacteria,4D3K9@85005|Actinomycetales	201174|Actinobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	GO:0000018,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009892,GO:0009987,GO:0010605,GO:0016020,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0045910,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051716,GO:0060255,GO:0060542,GO:0060543,GO:0065007,GO:0071944,GO:0080090	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
REGS1_k127_1004528_11	868595.Desca_0253	1.699e-10	62.0	COG2078@1|root,COG3885@1|root,COG2078@2|Bacteria,COG3885@2|Bacteria,1TQH8@1239|Firmicutes,2491Q@186801|Clostridia,26152@186807|Peptococcaceae	186801|Clostridia	S	pfam ammecr1	-	-	-	ko:K06990,ko:K09141	-	-	-	-	ko00000,ko04812	-	-	-	AMMECR1,LigB
REGS1_k127_1004528_10	1304875.JAFZ01000001_gene952	1.991e-13	78.0	COG2197@1|root,COG2197@2|Bacteria,3TB23@508458|Synergistetes	508458|Synergistetes	K	response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
REGS1_k127_1004528_8	1128421.JAGA01000002_gene1640	1.23e-26	121.0	COG2259@1|root,COG2259@2|Bacteria,2NQ4C@2323|unclassified Bacteria	2|Bacteria	S	DoxX	-	-	1.8.5.2	ko:K15977,ko:K16937	ko00920,ko01120,map00920,map01120	-	R07177	-	ko00000,ko00001,ko01000	3.D.4.9	-	-	DoxX
REGS1_k127_1004528_9	292459.STH2407	2.613e-16	84.0	COG2259@1|root,COG2259@2|Bacteria,1V38Q@1239|Firmicutes,25DF1@186801|Clostridia	186801|Clostridia	S	DoxX	-	-	1.8.5.2	ko:K16937	ko00920,ko01120,map00920,map01120	-	R07177	-	ko00000,ko00001,ko01000	3.D.4.9	-	-	DoxX
REGS1_k127_1004528_4	1382356.JQMP01000004_gene592	9.042e-68	238.0	COG2197@1|root,COG2197@2|Bacteria,2G8EU@200795|Chloroflexi,27XKP@189775|Thermomicrobia	189775|Thermomicrobia	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
REGS1_k127_1004528_5	479434.Sthe_0156	1.096e-62	232.0	COG3850@1|root,COG3850@2|Bacteria,2GBH4@200795|Chloroflexi,27XF0@189775|Thermomicrobia	189775|Thermomicrobia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA_3
REGS1_k127_1004528_0	926569.ANT_16680	4.628e-221	706.0	COG0317@1|root,COG0317@2|Bacteria,2G67Y@200795|Chloroflexi	200795|Chloroflexi	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
REGS1_k127_1004528_3	1304880.JAGB01000002_gene2320	2.082e-89	313.0	COG0037@1|root,COG0037@2|Bacteria,1TPXP@1239|Firmicutes,248TY@186801|Clostridia	186801|Clostridia	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3,TilS,TilS_C
REGS1_k127_1004528_7	1382306.JNIM01000001_gene1619	1.089e-26	115.0	COG0799@1|root,COG0799@2|Bacteria,2G77A@200795|Chloroflexi	200795|Chloroflexi	J	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation	rsfS	-	-	ko:K09710	-	-	-	-	ko00000,ko03009	-	-	-	RsfS
REGS1_k127_1004528_6	572546.Arcpr_0498	2.279e-50	184.0	COG0105@1|root,arCOG04313@2157|Archaea,2XWSK@28890|Euryarchaeota,2465T@183980|Archaeoglobi	183980|Archaeoglobi	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	-	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
REGS1_k127_1004528_12	936455.KI421499_gene3169	3.19e-06	61.0	COG0457@1|root,COG0457@2|Bacteria,1MUZK@1224|Proteobacteria,2TS0U@28211|Alphaproteobacteria,3JRSC@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9,TPR_1,TPR_10,TPR_11,TPR_16,TPR_19,TPR_2,TPR_4,TPR_7,TPR_8
REGS1_k127_1004528_1	1128421.JAGA01000002_gene1016	8.051e-101	340.0	COG0123@1|root,COG0123@2|Bacteria,2NPB6@2323|unclassified Bacteria	2|Bacteria	BQ	Histone deacetylase domain	acuC	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
REGS1_k127_1004528_2	479434.Sthe_0890	1.325e-96	327.0	COG1215@1|root,COG1215@2|Bacteria,2G6E4@200795|Chloroflexi,27Z3C@189775|Thermomicrobia	189775|Thermomicrobia	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
REGS1_k127_1011385_1	926550.CLDAP_23390	7.594e-21	106.0	COG1807@1|root,COG1807@2|Bacteria,2G9BJ@200795|Chloroflexi	2|Bacteria	M	Protein of unknown function (DUF2723)	-	-	-	ko:K14340	-	-	-	-	ko00000,ko01000,ko01003	-	-	-	PMT_2
REGS1_k127_1011385_0	926550.CLDAP_05500	1.14e-207	672.0	COG1193@1|root,COG1193@2|Bacteria,2G5R8@200795|Chloroflexi	200795|Chloroflexi	L	Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity	mutS2	-	-	ko:K07456	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_III,MutS_V,Smr
REGS1_k127_1011385_3	765420.OSCT_0940	2.68e-05	53.0	2BY4B@1|root,2ZSE3@2|Bacteria,2GAFB@200795|Chloroflexi,375X8@32061|Chloroflexia	32061|Chloroflexia	S	Colicin V production protein	-	-	-	ko:K03558	-	-	-	-	ko00000	-	-	-	Colicin_V
REGS1_k127_1011385_2	926569.ANT_24980	4.605e-14	73.0	COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,2G5QR@200795|Chloroflexi	200795|Chloroflexi	J	phenylalanyl-tRNA synthetase beta subunit	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
REGS1_k127_1017195_2	391624.OIHEL45_05760	7.271e-17	88.0	COG1409@1|root,COG1409@2|Bacteria,1MW6B@1224|Proteobacteria,2U57H@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	phosphohydrolases	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Metallophos_2
REGS1_k127_1017195_0	525904.Tter_0560	1.32e-215	681.0	COG1012@1|root,COG1012@2|Bacteria,2NNR8@2323|unclassified Bacteria	2|Bacteria	C	Belongs to the aldehyde dehydrogenase family	ycbD	-	1.2.1.3	ko:K00128,ko:K22187	ko00010,ko00040,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00040,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146,R11768	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
REGS1_k127_1017195_3	926550.CLDAP_35190	8.453e-15	78.0	2FKJC@1|root,34C6D@2|Bacteria,2G9T3@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_1017195_1	926560.KE387027_gene263	7.458e-21	102.0	COG2120@1|root,COG2120@2|Bacteria	2|Bacteria	S	N-acetylglucosaminylinositol deacetylase activity	-	-	-	ko:K22135	-	-	-	-	ko00000,ko01000	-	-	-	PIG-L
REGS1_k127_1021944_1	525904.Tter_1614	1.457e-97	341.0	COG0768@1|root,COG0768@2|Bacteria,2NNWR@2323|unclassified Bacteria	2|Bacteria	M	Penicillin-binding Protein dimerisation domain	ftsI	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008144,GO:0008150,GO:0008658,GO:0008955,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0031224,GO:0031226,GO:0031406,GO:0032153,GO:0033218,GO:0033293,GO:0036094,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043177,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051301,GO:0071944,GO:0097159,GO:1901363,GO:1901681	3.4.16.4	ko:K03587,ko:K08384	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	iSSON_1240.SSON_0092	PASTA,PBP_dimer,Transpeptidase
REGS1_k127_1021944_2	383372.Rcas_1103	4.217e-93	313.0	COG0275@1|root,COG0275@2|Bacteria,2G658@200795|Chloroflexi,374SY@32061|Chloroflexia	32061|Chloroflexia	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
REGS1_k127_1021944_4	1123239.KB898623_gene961	6.739e-35	143.0	COG2001@1|root,COG2001@2|Bacteria,1V3JD@1239|Firmicutes,4HH23@91061|Bacilli	91061|Bacilli	K	Belongs to the MraZ family	mraZ	GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
REGS1_k127_1021944_8	552811.Dehly_0125	7.579e-13	77.0	COG1579@1|root,COG1579@2|Bacteria,2G775@200795|Chloroflexi,34D9U@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Zn-ribbon protein possibly nucleic acid-binding	-	-	-	ko:K07164	-	-	-	-	ko00000	-	-	-	zf-RING_7
REGS1_k127_1021944_6	378806.STAUR_6388	1.173e-31	129.0	COG0328@1|root,COG0328@2|Bacteria,1MZD1@1224|Proteobacteria,42UI6@68525|delta/epsilon subdivisions,2WQSU@28221|Deltaproteobacteria,2YXKN@29|Myxococcales	28221|Deltaproteobacteria	L	Reverse transcriptase-like	rnhA	-	3.1.26.4	ko:K03469	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RVT_3
REGS1_k127_1021944_7	635013.TherJR_1860	9.304e-23	100.0	COG1872@1|root,COG1872@2|Bacteria,1VFSH@1239|Firmicutes,24T87@186801|Clostridia,262RJ@186807|Peptococcaceae	186801|Clostridia	S	Belongs to the UPF0235 family	-	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
REGS1_k127_1021944_5	240015.ACP_2902	3.299e-34	136.0	COG1051@1|root,COG1051@2|Bacteria,3Y5BM@57723|Acidobacteria,2JJTC@204432|Acidobacteriia	204432|Acidobacteriia	F	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
REGS1_k127_1021944_0	765420.OSCT_2657	2.422e-143	473.0	COG0608@1|root,COG0608@2|Bacteria,2G5US@200795|Chloroflexi,374UZ@32061|Chloroflexia	32061|Chloroflexia	L	PFAM phosphoesterase, RecJ domain protein	-	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
REGS1_k127_1021944_3	926569.ANT_20820	4.535e-62	220.0	COG0223@1|root,COG0223@2|Bacteria,2G69J@200795|Chloroflexi	200795|Chloroflexi	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
REGS1_k127_1045871_6	926550.CLDAP_04900	1.507e-08	68.0	COG3391@1|root,COG4447@1|root,COG3391@2|Bacteria,COG4447@2|Bacteria,2G9C0@200795|Chloroflexi	200795|Chloroflexi	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_1045871_4	272630.MexAM1_META1p4527	2.901e-15	91.0	COG3391@1|root,COG3391@2|Bacteria,1RF7X@1224|Proteobacteria,2U7M2@28211|Alphaproteobacteria,1JTA5@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	TIGRFAM 40-residue YVTN family beta-propeller repeat protein	mxaE	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_D1,Lactonase,NHL
REGS1_k127_1045871_0	697284.ERIC2_c01510	3.374e-40	153.0	COG0359@1|root,COG0359@2|Bacteria,1V6QG@1239|Firmicutes,4HIKJ@91061|Bacilli,26X3A@186822|Paenibacillaceae	91061|Bacilli	J	binds to the 23S rRNA	rplI	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
REGS1_k127_1045871_1	1168289.AJKI01000002_gene2245	9.149e-36	139.0	COG3118@1|root,COG3118@2|Bacteria,4NQ5B@976|Bacteroidetes,2FTV5@200643|Bacteroidia,3XK86@558415|Marinilabiliaceae	976|Bacteroidetes	O	Thioredoxin-like domain	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
REGS1_k127_1045871_5	1246626.BleG1_2423	6.15e-14	75.0	COG1937@1|root,COG1937@2|Bacteria,1VEF5@1239|Firmicutes,4HKJV@91061|Bacilli,1ZQH8@1386|Bacillus	91061|Bacilli	S	transcriptional	csoR	GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141	-	ko:K21600	-	-	-	-	ko00000,ko03000	-	-	-	Trns_repr_metal
REGS1_k127_1045871_2	880073.Calab_1228	4.633e-34	137.0	COG3634@1|root,COG3634@2|Bacteria,2NPR2@2323|unclassified Bacteria	2|Bacteria	O	Thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_3
REGS1_k127_1045871_3	644966.Tmar_0248	4.397e-18	86.0	COG3634@1|root,COG3634@2|Bacteria,1V40Z@1239|Firmicutes,24JKA@186801|Clostridia	186801|Clostridia	O	TIGRFAM Glutaredoxin-like domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_3
REGS1_k127_107251_0	1382306.JNIM01000001_gene663	1.565e-180	588.0	COG2366@1|root,COG2366@2|Bacteria,2G63N@200795|Chloroflexi	200795|Chloroflexi	S	PFAM peptidase S45 penicillin amidase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
REGS1_k127_107251_1	926560.KE387027_gene1021	1.326e-105	353.0	2DB7V@1|root,2Z7NX@2|Bacteria,1WM7S@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_1100086_0	196490.AUEZ01000042_gene7227	0.0	1058.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TQMW@28211|Alphaproteobacteria,3JSZE@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
REGS1_k127_1100086_1	1123024.AUII01000009_gene1953	4.539e-46	168.0	COG0388@1|root,COG0388@2|Bacteria,2HW1E@201174|Actinobacteria,4EAGX@85010|Pseudonocardiales	201174|Actinobacteria	S	Carbon-nitrogen hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
REGS1_k127_110500_2	316067.Geob_2547	4.153e-10	63.0	COG3089@1|root,COG3089@2|Bacteria	2|Bacteria	S	Uncharacterised protein family (UPF0270)	yheU	-	-	ko:K07019,ko:K09898	-	-	-	-	ko00000	-	-	-	UPF0270
REGS1_k127_110500_1	926569.ANT_25520	5.668e-53	195.0	COG0503@1|root,COG0503@2|Bacteria,2G71F@200795|Chloroflexi	200795|Chloroflexi	F	Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis	xpt	-	2.4.2.22	ko:K03816	ko00230,ko01100,ko01110,map00230,map01100,map01110	-	R01229,R02142	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
REGS1_k127_110500_0	357808.RoseRS_2132	8.918e-164	527.0	COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,2G5WB@200795|Chloroflexi,374SN@32061|Chloroflexia	32061|Chloroflexia	F	Catalyzes the synthesis of GMP from XMP	guaA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C
REGS1_k127_111534_6	553219.CAMSH0001_0752	1.528e-10	73.0	COG0845@1|root,COG0845@2|Bacteria,1R3U4@1224|Proteobacteria,43D29@68525|delta/epsilon subdivisions,2YTFT@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	M	HlyD family secretion protein	-	-	-	ko:K01993	-	-	-	-	ko00000	-	-	-	HlyD_3
REGS1_k127_111534_0	264732.Moth_1900	8.572e-105	348.0	COG1131@1|root,COG1131@2|Bacteria,1TQKM@1239|Firmicutes,25B35@186801|Clostridia,42FFN@68295|Thermoanaerobacterales	186801|Clostridia	V	pfam abc	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
REGS1_k127_111534_1	243231.GSU3608	1.453e-92	313.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,42PIB@68525|delta/epsilon subdivisions,2WKFC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	ABC transporter	ybhF-N	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
REGS1_k127_111534_3	1444309.JAQG01000020_gene600	1.536e-47	184.0	COG0842@1|root,COG0842@2|Bacteria,1TQG7@1239|Firmicutes,4H9MK@91061|Bacilli,274ZQ@186822|Paenibacillaceae	91061|Bacilli	V	ABC-2 type transporter	ybhR	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane,ABC2_membrane_3
REGS1_k127_111534_2	264732.Moth_1899	7.971e-56	210.0	COG0842@1|root,COG0842@2|Bacteria,1TQG7@1239|Firmicutes,249TT@186801|Clostridia,42ETY@68295|Thermoanaerobacterales	186801|Clostridia	V	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
REGS1_k127_111534_5	926550.CLDAP_36910	8.495e-12	73.0	COG1309@1|root,COG1309@2|Bacteria,2G8XR@200795|Chloroflexi	200795|Chloroflexi	K	PFAM regulatory protein TetR	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
REGS1_k127_111534_4	1121272.KB903290_gene4634	2.418e-25	111.0	COG0697@1|root,COG0697@2|Bacteria,2IH82@201174|Actinobacteria	201174|Actinobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
REGS1_k127_1121882_7	1268072.PSAB_13800	9.818e-18	94.0	COG0167@1|root,COG0167@2|Bacteria,1TPFV@1239|Firmicutes,4HA5H@91061|Bacilli,26TD6@186822|Paenibacillaceae	91061|Bacilli	F	Catalyzes the conversion of dihydroorotate to orotate	pyrD	GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	1.3.1.14,1.3.98.1	ko:K00226,ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01867,R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	iYO844.BSU15540	DHO_dh
REGS1_k127_1121882_4	867845.KI911784_gene2238	1.066e-49	181.0	COG1490@1|root,COG1490@2|Bacteria,2G6P5@200795|Chloroflexi,3778M@32061|Chloroflexia	32061|Chloroflexia	J	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality	dtd	GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360	-	ko:K07560	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Tyr_Deacylase
REGS1_k127_1121882_5	926569.ANT_19040	4.642e-23	102.0	2EUFH@1|root,31CAS@2|Bacteria,2G9NZ@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_1121882_8	479434.Sthe_1592	2.251e-16	83.0	COG2331@1|root,COG2331@2|Bacteria,2G752@200795|Chloroflexi,27YP8@189775|Thermomicrobia	189775|Thermomicrobia	S	Putative regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
REGS1_k127_1121882_2	1125863.JAFN01000001_gene3190	1.528e-79	275.0	COG2199@1|root,COG3706@2|Bacteria,1QUKY@1224|Proteobacteria,42NYY@68525|delta/epsilon subdivisions,2WKIY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	PFAM GGDEF domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Response_reg
REGS1_k127_1121882_3	926569.ANT_03800	4.437e-74	259.0	COG0030@1|root,COG0030@2|Bacteria,2G6DA@200795|Chloroflexi	200795|Chloroflexi	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
REGS1_k127_1121882_1	926550.CLDAP_30410	4.217e-81	289.0	COG3583@1|root,COG3584@1|root,COG3583@2|Bacteria,COG3584@2|Bacteria,2G8CU@200795|Chloroflexi	200795|Chloroflexi	S	Domain of unknown function (DUF348)	-	-	-	-	-	-	-	-	-	-	-	-	DUF348,G5
REGS1_k127_1121882_0	525904.Tter_0805	5.693e-176	560.0	COG0334@1|root,COG0334@2|Bacteria,2NNRJ@2323|unclassified Bacteria	2|Bacteria	E	Belongs to the Glu Leu Phe Val dehydrogenases family	gdhA	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
REGS1_k127_1121882_6	1232428.CAVO010000051_gene2162	1.76e-19	90.0	COG0064@1|root,COG0064@2|Bacteria,1TPG3@1239|Firmicutes,4H327@909932|Negativicutes	909932|Negativicutes	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	-	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
REGS1_k127_1126089_2	926569.ANT_30100	1.19e-28	132.0	COG2905@1|root,COG2905@2|Bacteria	2|Bacteria	T	signal-transduction protein containing cAMP-binding and CBS domains	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin,Lactamase_B,Lactamase_B_2,cNMP_binding
REGS1_k127_1126089_0	1304880.JAGB01000001_gene365	4.391e-191	616.0	COG0322@1|root,COG0322@2|Bacteria,1TP4B@1239|Firmicutes,247TQ@186801|Clostridia	186801|Clostridia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
REGS1_k127_1126089_1	926569.ANT_23560	1.174e-37	148.0	2DM5T@1|root,31U0Y@2|Bacteria,2G78W@200795|Chloroflexi	200795|Chloroflexi	S	Domain of unknown function (DUF4126)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4126
REGS1_k127_1126089_5	926550.CLDAP_09750	2.71e-08	60.0	COG4818@1|root,COG4818@2|Bacteria,2G9PA@200795|Chloroflexi	200795|Chloroflexi	S	Domain of unknown function (DUF4870)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4870
REGS1_k127_1126089_3	309801.trd_0665	1.356e-24	113.0	2DPX2@1|root,333RW@2|Bacteria,2G7A0@200795|Chloroflexi,27Z8D@189775|Thermomicrobia	189775|Thermomicrobia	S	Protein of unknown function (DUF4013)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4013
REGS1_k127_1134742_0	926550.CLDAP_38200	0.0	1155.0	COG0086@1|root,COG0086@2|Bacteria,2G632@200795|Chloroflexi	200795|Chloroflexi	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
REGS1_k127_1134742_1	1123252.ATZF01000007_gene246	4.227e-18	95.0	COG4974@1|root,COG4974@2|Bacteria,1TSHQ@1239|Firmicutes,4HG9P@91061|Bacilli,27C9F@186824|Thermoactinomycetaceae	91061|Bacilli	L	Phage integrase family	-	-	-	ko:K03733	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_int_SAM_4,Phage_integrase
REGS1_k127_1173399_2	316274.Haur_0619	8.29e-57	209.0	COG0194@1|root,COG0194@2|Bacteria,2G6EW@200795|Chloroflexi,375HJ@32061|Chloroflexia	32061|Chloroflexia	F	Essential for recycling GMP and indirectly, cGMP	gmk	-	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
REGS1_k127_1173399_0	246197.MXAN_2689	2.166e-147	481.0	COG0677@1|root,COG0677@2|Bacteria,1MUC6@1224|Proteobacteria,42M4F@68525|delta/epsilon subdivisions,2WJEW@28221|Deltaproteobacteria,2YTWM@29|Myxococcales	28221|Deltaproteobacteria	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	capL	-	1.1.1.136,1.1.1.336	ko:K02472,ko:K02474,ko:K13015	ko00520,ko05111,map00520,map05111	-	R00421,R03317,R06894	RC00291	ko00000,ko00001,ko01000,ko01005	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
REGS1_k127_1173399_3	383372.Rcas_0345	2.989e-08	64.0	2DPX2@1|root,333RW@2|Bacteria,2G7A0@200795|Chloroflexi,377B3@32061|Chloroflexia	32061|Chloroflexia	S	Protein of unknown function (DUF4013)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4013
REGS1_k127_1173399_1	357808.RoseRS_4524	8.637e-75	258.0	COG0472@1|root,COG0472@2|Bacteria,2G7WQ@200795|Chloroflexi,375BA@32061|Chloroflexia	32061|Chloroflexia	M	PFAM glycosyl transferase family 4	-	-	2.7.8.33,2.7.8.35	ko:K02851	-	-	R08856	RC00002	ko00000,ko01000,ko01003,ko01005	-	-	-	Glycos_transf_4
REGS1_k127_118266_9	357808.RoseRS_4300	8.557e-43	175.0	COG1807@1|root,COG1807@2|Bacteria,2G8TF@200795|Chloroflexi,376E7@32061|Chloroflexia	32061|Chloroflexia	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
REGS1_k127_118266_4	1128421.JAGA01000002_gene382	1.97e-73	273.0	COG1807@1|root,COG3063@1|root,COG1807@2|Bacteria,COG3063@2|Bacteria	2|Bacteria	NU	photosynthesis	pilF	-	-	ko:K02453,ko:K02656	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15	-	-	ANAPC5,Secretin,TPR_16,TPR_19,TPR_2,TPR_4,TPR_8
REGS1_k127_118266_10	246197.MXAN_4014	3.769e-07	64.0	COG4409@1|root,COG4409@2|Bacteria	2|Bacteria	G	exo-alpha-(2->6)-sialidase activity	nanA	GO:0001573,GO:0003674,GO:0003824,GO:0004308,GO:0004553,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006629,GO:0006643,GO:0006664,GO:0006665,GO:0006672,GO:0006687,GO:0006689,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009311,GO:0009313,GO:0009987,GO:0016020,GO:0016042,GO:0016052,GO:0016787,GO:0016798,GO:0016997,GO:0019377,GO:0030149,GO:0034641,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043603,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044424,GO:0044464,GO:0046466,GO:0046479,GO:0046514,GO:0071704,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575,GO:1903509	3.2.1.18	ko:K01186	ko00511,ko00600,ko04142,map00511,map00600,map04142	-	R04018	RC00028,RC00077	ko00000,ko00001,ko01000,ko02042	-	GH33	-	BNR_2,Gram_pos_anchor,Sialidase,YSIRK_signal
REGS1_k127_118266_3	316274.Haur_4272	5.673e-84	298.0	COG3463@1|root,COG3463@2|Bacteria,2G8G9@200795|Chloroflexi,375MF@32061|Chloroflexia	32061|Chloroflexia	S	Predicted membrane protein (DUF2079)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2079
REGS1_k127_118266_0	316274.Haur_4277	7.854e-113	385.0	COG1287@1|root,COG1287@2|Bacteria,2G9P1@200795|Chloroflexi,375X4@32061|Chloroflexia	32061|Chloroflexia	S	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
REGS1_k127_118266_5	1128421.JAGA01000002_gene383	4.877e-72	255.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	2.1.1.222,2.1.1.64	ko:K00568	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11
REGS1_k127_118266_7	316274.Haur_4275	1.895e-62	234.0	COG2244@1|root,COG2244@2|Bacteria,2GAD3@200795|Chloroflexi,375HA@32061|Chloroflexia	32061|Chloroflexia	S	polysaccharide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt_C
REGS1_k127_118266_6	279714.FuraDRAFT_0228	1.636e-64	236.0	COG0438@1|root,COG0438@2|Bacteria,1PEZ0@1224|Proteobacteria,2W92V@28216|Betaproteobacteria,2KT86@206351|Neisseriales	206351|Neisseriales	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
REGS1_k127_118266_2	1128421.JAGA01000004_gene2536	2.9e-94	325.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
REGS1_k127_118266_8	316274.Haur_4274	4.444e-53	194.0	COG0500@1|root,COG2226@2|Bacteria,2G780@200795|Chloroflexi	200795|Chloroflexi	Q	PFAM Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
REGS1_k127_118266_1	383372.Rcas_3084	9.091e-109	361.0	COG0451@1|root,COG0451@2|Bacteria,2G6ET@200795|Chloroflexi,375HU@32061|Chloroflexia	32061|Chloroflexia	M	short-chain dehydrogenase reductase SDR	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
REGS1_k127_1195908_2	926550.CLDAP_34520	4.187e-70	243.0	COG1186@1|root,COG1186@2|Bacteria,2G5P6@200795|Chloroflexi	200795|Chloroflexi	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
REGS1_k127_1195908_1	457570.Nther_1366	9.329e-88	301.0	COG0552@1|root,COG0552@2|Bacteria,1TPRI@1239|Firmicutes,247JD@186801|Clostridia	186801|Clostridia	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
REGS1_k127_1195908_3	1123322.KB904662_gene4130	3.047e-12	70.0	COG0695@1|root,COG0695@2|Bacteria,2IR0P@201174|Actinobacteria	201174|Actinobacteria	O	PFAM Glutaredoxin 2	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF836
REGS1_k127_1195908_0	926550.CLDAP_10300	4.779e-94	330.0	COG0587@1|root,COG0587@2|Bacteria,2G5IY@200795|Chloroflexi	200795|Chloroflexi	L	TIGRFAM DNA polymerase III, alpha subunit	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
REGS1_k127_120564_0	383372.Rcas_2508	8.574e-137	450.0	COG1721@1|root,COG1721@2|Bacteria,2G7PU@200795|Chloroflexi,375DS@32061|Chloroflexia	32061|Chloroflexia	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
REGS1_k127_120564_1	357808.RoseRS_1835	1.597e-134	434.0	COG0714@1|root,COG0714@2|Bacteria,2G85W@200795|Chloroflexi,3759A@32061|Chloroflexia	32061|Chloroflexia	S	ATPase associated with various cellular activities, AAA_3	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
REGS1_k127_1213601_3	383372.Rcas_3156	1.973e-78	274.0	2DSCK@1|root,32USS@2|Bacteria,2GAKK@200795|Chloroflexi,376NF@32061|Chloroflexia	32061|Chloroflexia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_1213601_6	1343739.PAP_04770	1.385e-41	156.0	COG1545@1|root,arCOG01285@2157|Archaea,2XXGF@28890|Euryarchaeota,24400@183968|Thermococci	183968|Thermococci	V	DUF35 OB-fold domain, acyl-CoA-associated	acaC	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
REGS1_k127_1213601_2	926550.CLDAP_27990	8.175e-131	428.0	COG0183@1|root,COG0183@2|Bacteria,2G63J@200795|Chloroflexi	200795|Chloroflexi	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
REGS1_k127_1213601_0	342949.PNA2_1291	2.893e-145	468.0	COG3425@1|root,arCOG01767@2157|Archaea,2XTWE@28890|Euryarchaeota,243JV@183968|Thermococci	183968|Thermococci	I	Belongs to the UPF0219 family	-	-	2.3.3.10	ko:K01641	ko00072,ko00280,ko00650,ko00900,ko01100,ko01110,ko01130,map00072,map00280,map00650,map00900,map01100,map01110,map01130	M00088,M00095	R01978	RC00004,RC00503	ko00000,ko00001,ko00002,ko01000	-	-	-	ACP_syn_III,ACP_syn_III_C,HMG_CoA_synt_N
REGS1_k127_1213601_1	324602.Caur_0236	6.673e-132	433.0	COG1257@1|root,COG1257@2|Bacteria,2G5QV@200795|Chloroflexi,375AX@32061|Chloroflexia	32061|Chloroflexia	C	Belongs to the HMG-CoA reductase family	-	-	1.1.1.88	ko:K00054	ko00900,ko01110,ko01130,map00900,map01110,map01130	-	R02081	RC00004,RC00644	ko00000,ko00001,ko01000	-	-	-	HMG-CoA_red
REGS1_k127_1213601_9	1279017.AQYJ01000024_gene1130	9.655e-05	52.0	COG3303@1|root,COG3303@2|Bacteria,1R5JF@1224|Proteobacteria,1S13K@1236|Gammaproteobacteria,4667Z@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	Cytochrome c3	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C552,Cytochrom_c3_2
REGS1_k127_1213601_5	525904.Tter_0584	1.112e-59	222.0	COG2041@1|root,COG2041@2|Bacteria,2NQ7J@2323|unclassified Bacteria	2|Bacteria	S	Oxidoreductase molybdopterin binding domain	yedY	-	1.8.3.1	ko:K00387,ko:K07147	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00533	RC00168	ko00000,ko00001,ko01000	-	-	-	Mo-co_dimer,Oxidored_molyb
REGS1_k127_1213601_8	926550.CLDAP_20100	8.603e-08	61.0	COG0723@1|root,COG0723@2|Bacteria,2G7BG@200795|Chloroflexi	200795|Chloroflexi	C	Rieske [2Fe-2S] domain	-	-	1.10.9.1	ko:K02636	ko00195,ko01100,map00195,map01100	M00162	R03817,R08409	RC01002	ko00000,ko00001,ko00002,ko00194,ko01000	-	-	-	Rieske
REGS1_k127_1213601_7	1125863.JAFN01000001_gene3579	9.4e-10	62.0	COG1977@1|root,COG1977@2|Bacteria,1NH6M@1224|Proteobacteria,42X05@68525|delta/epsilon subdivisions,2WSK5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	PFAM thiamineS protein	-	-	-	-	-	-	-	-	-	-	-	-	ThiS,Ub-Mut7C
REGS1_k127_1213601_4	335543.Sfum_1736	2.47e-70	251.0	COG1893@1|root,COG1893@2|Bacteria,1MX5M@1224|Proteobacteria,43DN9@68525|delta/epsilon subdivisions,2X25J@28221|Deltaproteobacteria,2MS0P@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
REGS1_k127_1216317_5	760192.Halhy_1744	2.125e-36	151.0	COG0641@1|root,COG0641@2|Bacteria,4NG1N@976|Bacteroidetes,1IUNW@117747|Sphingobacteriia	976|Bacteroidetes	C	Anaerobic sulfatase maturase	atsB	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
REGS1_k127_1216317_0	485913.Krac_0006	2.52e-183	583.0	COG1219@1|root,COG1219@2|Bacteria,2G661@200795|Chloroflexi	200795|Chloroflexi	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	-	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
REGS1_k127_1216317_3	311424.DhcVS_617	1.185e-75	263.0	COG0740@1|root,COG0740@2|Bacteria,2G6BN@200795|Chloroflexi,34D07@301297|Dehalococcoidia	301297|Dehalococcoidia	O	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
REGS1_k127_1216317_4	562970.Btus_0642	7.809e-58	219.0	COG0544@1|root,COG0544@2|Bacteria,1TQQ8@1239|Firmicutes,4H9Q8@91061|Bacilli,277WA@186823|Alicyclobacillaceae	91061|Bacilli	D	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
REGS1_k127_1216317_7	526227.Mesil_2780	1.736e-11	77.0	COG3794@1|root,COG3794@2|Bacteria,1WKPV@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Copper binding proteins, plastocyanin/azurin family	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1
REGS1_k127_1216317_6	926550.CLDAP_26340	9.304e-15	88.0	COG1572@1|root,COG3292@1|root,COG1572@2|Bacteria,COG3292@2|Bacteria	2|Bacteria	NU	bacterial-type flagellum-dependent cell motility	-	-	-	-	-	-	-	-	-	-	-	-	BNR_assoc_N,Beta_helix,CARDB,Cleaved_Adhesin,DUF4465,Glyco_tran_WbsX,fn3
REGS1_k127_1216317_1	383372.Rcas_3187	4.952e-144	472.0	COG0527@1|root,COG0527@2|Bacteria,2G5U9@200795|Chloroflexi,37577@32061|Chloroflexia	32061|Chloroflexia	E	PFAM aspartate glutamate uridylate kinase	-	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT
REGS1_k127_1216317_2	309801.trd_0366	7.888e-123	403.0	COG0136@1|root,COG0136@2|Bacteria,2G5T9@200795|Chloroflexi,27XNM@189775|Thermomicrobia	189775|Thermomicrobia	C	Belongs to the aspartate-semialdehyde dehydrogenase family	-	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
REGS1_k127_1216317_8	290315.Clim_0586	3.59e-11	68.0	COG1403@1|root,COG1403@2|Bacteria	2|Bacteria	V	endonuclease activity	ninG	-	-	-	-	-	-	-	-	-	-	-	NinG
REGS1_k127_1246774_4	102129.Lepto7375DRAFT_1331	9.448e-07	51.0	COG0277@1|root,COG0277@2|Bacteria,1G176@1117|Cyanobacteria,1H7RA@1150|Oscillatoriales	1117|Cyanobacteria	C	FAD linked oxidases, C-terminal domain	glcE	-	-	ko:K11472	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	FAD-oxidase_C,FAD_binding_4
REGS1_k127_1246774_0	926569.ANT_07600	1.269e-111	366.0	COG0483@1|root,COG0483@2|Bacteria,2G7NN@200795|Chloroflexi	200795|Chloroflexi	G	PFAM inositol monophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Inositol_P
REGS1_k127_1246774_1	926550.CLDAP_37650	6.826e-105	347.0	COG2141@1|root,COG2141@2|Bacteria,2G5QC@200795|Chloroflexi	200795|Chloroflexi	C	PFAM Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
REGS1_k127_1246774_3	1234364.AMSF01000061_gene2077	5.577e-12	72.0	2EUEA@1|root,33MWN@2|Bacteria,1NYM7@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_1246774_2	666685.R2APBS1_0569	3.549e-40	151.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,1X3A2@135614|Xanthomonadales	135614|Xanthomonadales	P	COG0474 Cation transport ATPase	-	-	3.6.3.2	ko:K01531	-	-	-	-	ko00000,ko01000	3.A.3.4	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
REGS1_k127_1268886_5	694429.Pyrfu_0407	2.993e-24	107.0	COG1656@1|root,arCOG04290@2157|Archaea,2XQD5@28889|Crenarchaeota	28889|Crenarchaeota	S	Mut7-C RNAse domain	-	-	-	ko:K09122	-	-	-	-	ko00000	-	-	-	Mut7-C
REGS1_k127_1268886_8	426114.THI_0985	1.583e-16	84.0	COG3794@1|root,COG3794@2|Bacteria,1RI9G@1224|Proteobacteria,2VX9Q@28216|Betaproteobacteria	28216|Betaproteobacteria	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cupredoxin_1
REGS1_k127_1268886_0	926569.ANT_25420	6.5e-187	593.0	COG0148@1|root,COG0148@2|Bacteria,2G5VB@200795|Chloroflexi	200795|Chloroflexi	F	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
REGS1_k127_1268886_3	926550.CLDAP_10960	4.054e-46	173.0	COG2030@1|root,COG2030@2|Bacteria,2G966@200795|Chloroflexi	200795|Chloroflexi	I	MaoC like domain	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
REGS1_k127_1268886_4	439235.Dalk_1417	8.72e-33	130.0	COG1586@1|root,COG1586@2|Bacteria,1REQP@1224|Proteobacteria,42RVE@68525|delta/epsilon subdivisions,2WNJ5@28221|Deltaproteobacteria,2MJVH@213118|Desulfobacterales	28221|Deltaproteobacteria	E	S-adenosylmethionine decarboxylase	-	-	-	-	-	-	-	-	-	-	-	-	AdoMet_dc
REGS1_k127_1268886_1	671143.DAMO_2995	8.148e-114	377.0	COG1064@1|root,COG1064@2|Bacteria,2NP06@2323|unclassified Bacteria	2|Bacteria	S	Alcohol dehydrogenase GroES-like domain	adhA	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
REGS1_k127_1268886_7	926550.CLDAP_05380	3.71e-23	108.0	COG2318@1|root,COG2318@2|Bacteria,2G7AU@200795|Chloroflexi	200795|Chloroflexi	S	PFAM DinB family protein	-	-	-	-	-	-	-	-	-	-	-	-	DinB
REGS1_k127_1268886_6	1379698.RBG1_1C00001G0743	6.276e-24	110.0	COG2318@1|root,COG2318@2|Bacteria,2NRHG@2323|unclassified Bacteria	2|Bacteria	S	DinB superfamily	dinB	-	-	ko:K07552	-	-	-	-	ko00000,ko02000	2.A.1.2	-	-	DinB
REGS1_k127_1268886_2	479434.Sthe_0993	3.557e-66	237.0	COG1028@1|root,COG1028@2|Bacteria,2G8P1@200795|Chloroflexi,27XUC@189775|Thermomicrobia	189775|Thermomicrobia	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
REGS1_k127_1268892_0	525904.Tter_2700	1.161e-28	122.0	COG0673@1|root,COG0673@2|Bacteria,2NRRS@2323|unclassified Bacteria	2|Bacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	1.1.1.18,1.1.1.369	ko:K00010	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130	-	R01183,R09951	RC00182	ko00000,ko00001,ko01000	-	-	-	GFO_IDH_MocA
REGS1_k127_1268892_3	1449063.JMLS01000024_gene3715	1.804e-07	60.0	COG0613@1|root,COG0613@2|Bacteria,1V2U3@1239|Firmicutes,4HF4C@91061|Bacilli,26WDG@186822|Paenibacillaceae	91061|Bacilli	S	DNA polymerase alpha chain like domain	-	-	-	-	-	-	-	-	-	-	-	-	PHP
REGS1_k127_1268892_2	1128421.JAGA01000001_gene2056	1.422e-14	78.0	COG5002@1|root,COG5002@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	lisK	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
REGS1_k127_1268892_1	1232428.CAVO010000022_gene843	8.195e-20	91.0	COG0577@1|root,COG0577@2|Bacteria,1TPUU@1239|Firmicutes,4H2H6@909932|Negativicutes	909932|Negativicutes	V	Efflux ABC transporter permease protein	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
REGS1_k127_1312518_4	272623.L26878	5.281e-08	59.0	COG1963@1|root,COG1963@2|Bacteria,1VAVC@1239|Firmicutes,4HHA6@91061|Bacilli,1YCCB@1357|Lactococcus	91061|Bacilli	S	Divergent PAP2 family	yuiD	-	-	ko:K09775	-	-	-	-	ko00000	-	-	-	DUF212
REGS1_k127_1312518_3	591001.Acfer_0849	2.904e-10	67.0	COG1722@1|root,COG1722@2|Bacteria	2|Bacteria	L	exodeoxyribonuclease VII activity	xseB	-	3.1.11.6	ko:K03602	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_S
REGS1_k127_1312518_0	926569.ANT_26230	2.54e-109	366.0	COG1570@1|root,COG1570@2|Bacteria,2G5M3@200795|Chloroflexi	200795|Chloroflexi	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
REGS1_k127_1312518_1	1382356.JQMP01000003_gene2334	7.909e-64	225.0	COG0231@1|root,COG0231@2|Bacteria,2G6PY@200795|Chloroflexi,27Y78@189775|Thermomicrobia	189775|Thermomicrobia	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	efp	-	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
REGS1_k127_1312518_5	324057.Pjdr2_2672	0.0003695	46.0	2DRB4@1|root,33B1T@2|Bacteria,1VQCB@1239|Firmicutes,4I6X7@91061|Bacilli,26VDQ@186822|Paenibacillaceae	91061|Bacilli	S	YcxB-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YcxB
REGS1_k127_1312518_2	926569.ANT_15410	1.423e-41	155.0	COG1199@1|root,COG2176@1|root,COG1199@2|Bacteria,COG2176@2|Bacteria,2G5P4@200795|Chloroflexi	200795|Chloroflexi	L	PFAM Exonuclease, RNase T and DNA polymerase III	-	-	2.7.7.7,3.6.4.12	ko:K02342,ko:K03722	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DEAD,DEAD_2,Helicase_C_2,RNase_T
REGS1_k127_131304_2	526227.Mesil_3344	9.445e-25	113.0	COG5295@1|root,COG5295@2|Bacteria	2|Bacteria	UW	Hep Hag repeat protein	yeeJ	-	-	ko:K21449	-	-	-	-	ko00000,ko02000	1.B.40.2	-	-	DUF5122,Peptidase_S74,YadA_head,YadA_stalk
REGS1_k127_131304_1	573061.Clocel_3479	6.766e-36	146.0	COG0494@1|root,COG0494@2|Bacteria,1V5CY@1239|Firmicutes,24HM6@186801|Clostridia,36MGF@31979|Clostridiaceae	186801|Clostridia	L	NUDIX domain	-	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
REGS1_k127_131304_3	1069534.LRC_17510	2.035e-17	90.0	COG0406@1|root,COG0406@2|Bacteria,1V6ES@1239|Firmicutes,4HGZI@91061|Bacilli,3F5SD@33958|Lactobacillaceae	91061|Bacilli	G	phosphoglycerate mutase	pgm1	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
REGS1_k127_131304_0	436229.JOEH01000017_gene6937	4.613e-69	252.0	COG0477@1|root,COG2814@2|Bacteria,2HX42@201174|Actinobacteria,2NMEZ@228398|Streptacidiphilus	201174|Actinobacteria	EGP	Transmembrane secretion effector	bacE	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
REGS1_k127_1313259_0	926569.ANT_20890	7.313e-250	785.0	COG0465@1|root,COG0465@2|Bacteria,2G5J3@200795|Chloroflexi	200795|Chloroflexi	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
REGS1_k127_1313259_3	1449126.JQKL01000057_gene2258	6.899e-35	137.0	COG5496@1|root,COG5496@2|Bacteria,1VAZJ@1239|Firmicutes,24MWR@186801|Clostridia,2692N@186813|unclassified Clostridiales	186801|Clostridia	S	Thioesterase superfamily	-	-	3.1.2.29	ko:K18700	-	-	-	-	ko00000,ko01000	-	-	-	4HBT
REGS1_k127_1313259_2	926569.ANT_02700	1.287e-41	159.0	COG0346@1|root,COG0346@2|Bacteria,2G79M@200795|Chloroflexi	200795|Chloroflexi	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	5.1.99.1	ko:K05606	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R02765,R09979	RC00780,RC02739	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase_4
REGS1_k127_1313259_1	926550.CLDAP_17630	1.234e-217	681.0	COG1884@1|root,COG1884@2|Bacteria,2G62T@200795|Chloroflexi	200795|Chloroflexi	I	TIGRFAM methylmalonyl-CoA mutase, large subunit	-	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
REGS1_k127_132420_3	926569.ANT_16300	1.135e-71	246.0	COG0345@1|root,COG0345@2|Bacteria,2G5QD@200795|Chloroflexi	200795|Chloroflexi	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	-	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_oxidored,P5CR_dimer
REGS1_k127_132420_4	1504981.KO116_2280	5.061e-62	227.0	COG0644@1|root,COG0644@2|Bacteria,1R4JF@1224|Proteobacteria	1224|Proteobacteria	C	COG0644 Dehydrogenases (flavoproteins)	-	-	-	-	-	-	-	-	-	-	-	-	HI0933_like,NAD_binding_8
REGS1_k127_132420_2	926550.CLDAP_07930	2.81e-101	353.0	COG2720@1|root,COG2720@2|Bacteria,2G67R@200795|Chloroflexi	200795|Chloroflexi	V	PFAM VanW family protein	-	-	-	-	-	-	-	-	-	-	-	-	G5,PG_binding_4,VanW
REGS1_k127_132420_1	1382356.JQMP01000003_gene2308	8.047e-111	366.0	COG0616@1|root,COG0616@2|Bacteria,2G635@200795|Chloroflexi,27XH7@189775|Thermomicrobia	189775|Thermomicrobia	OU	Serine dehydrogenase proteinase	-	-	-	-	-	-	-	-	-	-	-	-	SDH_sah
REGS1_k127_132420_8	1157490.EL26_06935	1.883e-13	83.0	COG3023@1|root,COG3023@2|Bacteria,1TR62@1239|Firmicutes,4HGHR@91061|Bacilli,27AKP@186823|Alicyclobacillaceae	91061|Bacilli	V	Ami_2	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_2,SLT
REGS1_k127_132420_6	324602.Caur_0648	2.564e-51	199.0	COG3103@1|root,COG4991@2|Bacteria	2|Bacteria	T	sh3 domain protein	-	-	3.2.1.96	ko:K01227,ko:K03642	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000	-	-	-	DUF1236,Glucosaminidase,LysM,NLPC_P60,PA14,SH3_3,SLH
REGS1_k127_132420_9	907348.TresaDRAFT_2787	6.274e-05	54.0	COG0824@1|root,COG0824@2|Bacteria,2J837@203691|Spirochaetes	203691|Spirochaetes	S	acyl-CoA thioester hydrolase, YbgC YbaW family	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2
REGS1_k127_132420_7	1173025.GEI7407_3834	1.04e-13	82.0	COG0824@1|root,COG0824@2|Bacteria,1G6JT@1117|Cyanobacteria,1HBX0@1150|Oscillatoriales	1117|Cyanobacteria	S	TIGRFAM acyl-CoA thioester hydrolase, YbgC YbaW family	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	Acyl-ACP_TE
REGS1_k127_132420_0	632292.Calhy_1998	1.464e-123	408.0	COG1914@1|root,COG1914@2|Bacteria,1TPT1@1239|Firmicutes,24ACU@186801|Clostridia,42F5H@68295|Thermoanaerobacterales	186801|Clostridia	P	PFAM natural resistance-associated macrophage protein	-	-	-	-	-	-	-	-	-	-	-	-	Nramp
REGS1_k127_132420_5	485916.Dtox_1739	5.651e-59	209.0	COG1914@1|root,COG1914@2|Bacteria,1TPT1@1239|Firmicutes,24ACU@186801|Clostridia,260WD@186807|Peptococcaceae	186801|Clostridia	P	TIGRFAM NRAMP (natural resistance-associated macrophage protein) metal ion transporters	-	-	-	-	-	-	-	-	-	-	-	-	Nramp
REGS1_k127_1362830_12	552811.Dehly_1587	1.397e-11	69.0	COG1514@1|root,COG1514@2|Bacteria,2G76S@200795|Chloroflexi,34D41@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	-	-	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
REGS1_k127_1362830_0	926550.CLDAP_15350	3.618e-241	786.0	COG0744@1|root,COG0744@2|Bacteria,2G5ZG@200795|Chloroflexi	200795|Chloroflexi	M	PFAM glycosyl transferase, family 51	-	-	-	-	-	-	-	-	-	-	-	-	BiPBP_C,Transgly,Transpeptidase
REGS1_k127_1362830_9	1382356.JQMP01000003_gene2449	5.268e-20	93.0	COG4454@1|root,COG4454@2|Bacteria,2GA6H@200795|Chloroflexi,27YMB@189775|Thermomicrobia	189775|Thermomicrobia	P	Copper binding proteins, plastocyanin/azurin family	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1
REGS1_k127_1362830_5	926569.ANT_05580	2.126e-82	284.0	COG0496@1|root,COG0496@2|Bacteria,2G6XI@200795|Chloroflexi	200795|Chloroflexi	S	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates	surE	-	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	SurE
REGS1_k127_1362830_1	251229.Chro_5104	5.822e-181	576.0	COG0769@1|root,COG0769@2|Bacteria,1G226@1117|Cyanobacteria,3VI9J@52604|Pleurocapsales	1117|Cyanobacteria	M	Mur ligase middle domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF1727,Mur_ligase_M
REGS1_k127_1362830_2	1173021.ALWA01000012_gene1390	1.408e-117	383.0	COG3442@1|root,COG3442@2|Bacteria,1G1S3@1117|Cyanobacteria	1117|Cyanobacteria	S	PFAM CobB CobQ-like glutamine amidotransferase domain	-	-	-	ko:K07009	-	-	-	-	ko00000	-	-	-	GATase_3
REGS1_k127_1362830_3	1382306.JNIM01000001_gene3516	2.128e-113	374.0	COG0115@1|root,COG0115@2|Bacteria,2G5PM@200795|Chloroflexi	200795|Chloroflexi	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
REGS1_k127_1362830_13	1382356.JQMP01000004_gene265	3.227e-08	61.0	2A4QB@1|root,30TBJ@2|Bacteria,2GB9N@200795|Chloroflexi,27YCD@189775|Thermomicrobia	189775|Thermomicrobia	S	Protein of unknown function (DUF1648)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1648,bPH_5
REGS1_k127_1362830_7	485913.Krac_8513	6.627e-64	230.0	COG1836@1|root,COG1836@2|Bacteria,2G6N3@200795|Chloroflexi	200795|Chloroflexi	S	Integral membrane protein DUF92	-	-	-	-	-	-	-	-	-	-	-	-	DUF92
REGS1_k127_1362830_14	1521187.JPIM01000068_gene749	2.21e-07	65.0	COG2931@1|root,COG2931@2|Bacteria,2GA9F@200795|Chloroflexi,3775D@32061|Chloroflexia	32061|Chloroflexia	Q	TIGRFAM polymorphic outer membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	Chlam_PMP
REGS1_k127_1362830_8	479434.Sthe_0586	3.538e-54	218.0	COG3266@1|root,COG3266@2|Bacteria,2GBHM@200795|Chloroflexi,27Y68@189775|Thermomicrobia	189775|Thermomicrobia	S	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix
REGS1_k127_1362830_11	765420.OSCT_1103	8.464e-13	74.0	COG3212@1|root,COG3212@2|Bacteria,2GAED@200795|Chloroflexi,375S7@32061|Chloroflexia	32061|Chloroflexia	S	PFAM Propeptide, PepSY amd peptidase M4	-	-	-	-	-	-	-	-	-	-	-	-	PepSY
REGS1_k127_1362830_4	357808.RoseRS_0609	7.842e-97	326.0	COG1477@1|root,COG1477@2|Bacteria,2G6WH@200795|Chloroflexi,375JB@32061|Chloroflexia	32061|Chloroflexia	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	-	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
REGS1_k127_1362830_6	383372.Rcas_0225	2.559e-64	227.0	COG4097@1|root,COG4097@2|Bacteria,2G71Y@200795|Chloroflexi,375FI@32061|Chloroflexia	32061|Chloroflexia	P	Ferric reductase like transmembrane component	-	-	-	-	-	-	-	-	-	-	-	-	Ferric_reduct
REGS1_k127_1362830_10	671143.DAMO_2818	6.624e-18	85.0	COG0745@1|root,COG0745@2|Bacteria,2NPCK@2323|unclassified Bacteria	2|Bacteria	T	Two component transcriptional regulator, winged helix family	-	-	-	ko:K07658,ko:K07668	ko02020,map02020	M00434,M00459	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
REGS1_k127_1370448_4	1295642.H839_10223	1.244e-07	54.0	COG1984@1|root,COG1984@2|Bacteria,1TR6U@1239|Firmicutes,4HACC@91061|Bacilli,1WE6K@129337|Geobacillus	91061|Bacilli	E	Allophanate hydrolase subunit 2	kipA	-	-	ko:K06350	-	-	-	-	ko00000	-	-	-	CT_A_B
REGS1_k127_1370448_0	865861.AZSU01000003_gene2104	1.275e-102	346.0	COG1228@1|root,COG1228@2|Bacteria,1TQQ0@1239|Firmicutes,24EHA@186801|Clostridia,36DKU@31979|Clostridiaceae	186801|Clostridia	Q	Psort location Cytoplasmic, score 7.50	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
REGS1_k127_1370448_1	926550.CLDAP_08060	7.43e-81	279.0	COG2003@1|root,COG2003@2|Bacteria,2G6BK@200795|Chloroflexi	200795|Chloroflexi	L	Belongs to the UPF0758 family	-	-	-	ko:K03630	-	-	-	-	ko00000	-	-	-	RadC
REGS1_k127_1370448_3	1198114.AciX9_3377	1.467e-11	71.0	COG2318@1|root,COG2318@2|Bacteria,3Y4HW@57723|Acidobacteria,2JJ7C@204432|Acidobacteriia	204432|Acidobacteriia	S	Mycothiol maleylpyruvate isomerase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
REGS1_k127_1370448_2	525904.Tter_0060	3.1e-37	143.0	COG0772@1|root,COG0772@2|Bacteria,2NNRP@2323|unclassified Bacteria	2|Bacteria	D	Peptidoglycan polymerase that is essential for cell wall elongation	rodA	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
REGS1_k127_1376370_0	1128421.JAGA01000002_gene287	2.271e-70	248.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
REGS1_k127_1376370_2	1183438.GKIL_0830	1.034e-21	100.0	28NSZ@1|root,2ZBRT@2|Bacteria,1G51D@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_1376370_1	1521187.JPIM01000003_gene2965	1.745e-52	198.0	COG1466@1|root,COG1466@2|Bacteria,2G6XX@200795|Chloroflexi,37690@32061|Chloroflexia	32061|Chloroflexia	L	TIGRFAM DNA polymerase III, delta subunit	-	-	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta
REGS1_k127_1436945_3	644966.Tmar_0298	3.466e-18	83.0	COG0006@1|root,COG0006@2|Bacteria,1UY7B@1239|Firmicutes,24E77@186801|Clostridia	186801|Clostridia	E	Creatinase/Prolidase N-terminal domain	-	-	3.5.3.3	ko:K08688	ko00260,ko00330,ko01100,map00260,map00330,map01100	-	R01566	RC00548,RC00549	ko00000,ko00001,ko01000	-	-	-	Creatinase_N,Peptidase_M24
REGS1_k127_1436945_0	926569.ANT_19690	1.228e-196	622.0	COG0624@1|root,COG0624@2|Bacteria,2G5IT@200795|Chloroflexi	200795|Chloroflexi	E	PFAM peptidase M20	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
REGS1_k127_1436945_2	756272.Plabr_0071	3.093e-144	469.0	COG3635@1|root,COG3635@2|Bacteria,2IY5S@203682|Planctomycetes	203682|Planctomycetes	G	phosphoglycerate mutase	-	-	5.4.2.12	ko:K15635	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,PhosphMutase
REGS1_k127_1436945_1	945713.IALB_2901	9.03e-148	476.0	COG4948@1|root,COG4948@2|Bacteria	2|Bacteria	M	carboxylic acid catabolic process	menC	GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663	4.2.1.113	ko:K02549	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R04031	RC01053	ko00000,ko00001,ko00002,ko01000	-	-	-	AMP-binding,AMP-binding_C,MR_MLE_C,MR_MLE_N
REGS1_k127_1452632_8	1163408.UU9_09087	2.13e-07	53.0	COG5483@1|root,COG5483@2|Bacteria,1RDGV@1224|Proteobacteria,1S5VD@1236|Gammaproteobacteria,1XBWX@135614|Xanthomonadales	135614|Xanthomonadales	S	Protein of unknown function, DUF488	-	-	-	-	-	-	-	-	-	-	-	-	DUF488
REGS1_k127_1452632_6	1266925.JHVX01000001_gene2477	1.029e-31	126.0	2DP0W@1|root,3302Q@2|Bacteria,1N8JI@1224|Proteobacteria,2VWC3@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein of unknown function (DUF2945)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2945
REGS1_k127_1452632_3	246197.MXAN_7348	4.26e-55	196.0	COG3631@1|root,COG3631@2|Bacteria,1RDED@1224|Proteobacteria,43810@68525|delta/epsilon subdivisions,2X3B2@28221|Deltaproteobacteria,2YV6Y@29|Myxococcales	28221|Deltaproteobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
REGS1_k127_1452632_2	591158.SSMG_04372	3.095e-65	238.0	COG1454@1|root,COG3485@1|root,COG1454@2|Bacteria,COG3485@2|Bacteria,2I2FD@201174|Actinobacteria	201174|Actinobacteria	C	alcohol dehydrogenase	macA	-	1.3.1.32	ko:K00217	ko00361,ko00362,ko00364,ko00623,ko01100,ko01120,ko01220,map00361,map00362,map00364,map00623,map01100,map01120,map01220	-	R02988,R02989,R05355,R06848,R07781,R09137,R09138,R09223,R09224	RC00107,RC01335,RC01689,RC02442	ko00000,ko00001,ko01000	-	-	-	Dioxygenase_C,Dioxygenase_N,Fe-ADH
REGS1_k127_1452632_4	1298863.AUEP01000008_gene1241	9.984e-49	184.0	29ZNQ@1|root,30MP9@2|Bacteria,2IJUR@201174|Actinobacteria,4DUE8@85009|Propionibacteriales	201174|Actinobacteria	S	Mycothiol maleylpyruvate isomerase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_N
REGS1_k127_1452632_0	1382306.JNIM01000001_gene1512	1.235e-94	313.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
REGS1_k127_1452632_7	1382306.JNIM01000001_gene1513	6.132e-23	111.0	COG1670@1|root,COG1670@2|Bacteria	2|Bacteria	J	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_3,GNAT_acetyltran
REGS1_k127_1452632_1	485913.Krac_5625	1.039e-81	278.0	COG0400@1|root,COG0400@2|Bacteria,2G8M6@200795|Chloroflexi	200795|Chloroflexi	S	Phospholipase/Carboxylesterase	-	-	-	ko:K06999	-	-	-	-	ko00000	-	-	-	Abhydrolase_2
REGS1_k127_1452632_5	518766.Rmar_2770	6.518e-48	178.0	COG1975@1|root,COG2608@1|root,COG1975@2|Bacteria,COG2608@2|Bacteria,4NP35@976|Bacteroidetes	976|Bacteroidetes	O	COGs COG1975 Xanthine and CO dehydrogenase maturation factor XdhC CoxF family	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI,YHS
REGS1_k127_14653_3	1128421.JAGA01000002_gene1835	3.736e-26	110.0	COG0639@1|root,COG0639@2|Bacteria,2NPHT@2323|unclassified Bacteria	2|Bacteria	T	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos_2
REGS1_k127_14653_2	273068.TTE1898	4.265e-67	247.0	COG1568@1|root,COG1568@2|Bacteria,1UZNH@1239|Firmicutes,24CT0@186801|Clostridia,42F77@68295|Thermoanaerobacterales	186801|Clostridia	H	Involved in the biosynthesis of branched-chain polyamines, which support the growth of thermophiles under high- temperature conditions. Catalyzes the sequential condensation of spermidine with the aminopropyl groups of decarboxylated S- adenosylmethionines to produce N(4)-bis(aminopropyl)spermidine via N(4)-aminopropylspermidine	bpsA	-	2.5.1.128	ko:K07057	-	-	-	-	ko00000,ko01000	-	-	-	DUF43
REGS1_k127_14653_4	267377.MMP1583	1.377e-20	106.0	COG1586@1|root,arCOG00279@2157|Archaea,2XX6W@28890|Euryarchaeota,23QY1@183939|Methanococci	183939|Methanococci	F	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine	speH	-	4.1.1.50	ko:K01611	ko00270,ko00330,ko01100,map00270,map00330,map01100	M00034,M00133	R00178	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	AdoMet_dc
REGS1_k127_14653_1	1385514.N782_09870	4.061e-76	263.0	COG1277@1|root,COG1277@2|Bacteria,1V787@1239|Firmicutes,4IRME@91061|Bacilli,2YBAS@289201|Pontibacillus	91061|Bacilli	S	Bacitracin ABC transporter permease	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_4
REGS1_k127_14653_0	1034769.KB910518_gene2025	3.605e-83	282.0	COG1131@1|root,COG1131@2|Bacteria,1TPBQ@1239|Firmicutes,4HBXP@91061|Bacilli,26VNN@186822|Paenibacillaceae	91061|Bacilli	V	Bacitracin ABC transporter, ATP-binding protein	bcrA	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
REGS1_k127_1471103_2	1038862.KB893873_gene7491	3.034e-09	64.0	COG0392@1|root,COG0392@2|Bacteria,1MVZ8@1224|Proteobacteria,2TTDM@28211|Alphaproteobacteria,3JUC5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
REGS1_k127_1471103_1	357808.RoseRS_3472	4.607e-74	265.0	COG0438@1|root,COG0438@2|Bacteria,2GABK@200795|Chloroflexi,374ZN@32061|Chloroflexia	32061|Chloroflexia	M	PFAM glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
REGS1_k127_1471103_0	326427.Cagg_1401	1.647e-93	320.0	COG0438@1|root,COG0438@2|Bacteria,2GABS@200795|Chloroflexi,3752C@32061|Chloroflexia	32061|Chloroflexia	M	PFAM glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
REGS1_k127_1504084_3	926550.CLDAP_28940	6.332e-24	111.0	COG3266@1|root,COG3266@2|Bacteria	2|Bacteria	GM	domain, Protein	-	-	-	ko:K09766	-	-	-	-	ko00000	-	-	-	YSIRK_signal
REGS1_k127_1504084_1	926569.ANT_12010	7.862e-118	391.0	COG0533@1|root,COG0533@2|Bacteria,2G5V0@200795|Chloroflexi	200795|Chloroflexi	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0019538,GO:0043170,GO:0044238,GO:0071704,GO:1901564	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
REGS1_k127_1504084_2	290317.Cpha266_0893	2.13e-89	304.0	COG1357@1|root,COG1357@2|Bacteria	2|Bacteria	S	protein homooligomerization	-	-	-	-	-	-	-	-	-	-	-	-	Pentapeptide,TIR_2
REGS1_k127_1504084_0	926550.CLDAP_05570	3.147e-121	398.0	COG1921@1|root,COG1921@2|Bacteria,2G5VV@200795|Chloroflexi	200795|Chloroflexi	H	Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis	selA	-	2.9.1.1	ko:K01042	ko00450,ko00970,map00450,map00970	-	R08219	RC01246	ko00000,ko00001,ko01000	-	-	-	Se-cys_synth_N,SelA
REGS1_k127_1513501_5	1128421.JAGA01000002_gene682	2.184e-19	88.0	COG0214@1|root,COG0214@2|Bacteria,2NNZ6@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively	pdxS	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016020,GO:0016829,GO:0016840,GO:0016843,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0040007,GO:0042364,GO:0042802,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046184,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	4.3.3.6	ko:K06215	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SOR_SNZ
REGS1_k127_1513501_1	525904.Tter_0035	2.005e-76	260.0	COG0311@1|root,COG0311@2|Bacteria,2NPDR@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS	pdxT	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0008614,GO:0009058,GO:0009108,GO:0009110,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016829,GO:0016840,GO:0016843,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0040007,GO:0042364,GO:0042802,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0051716,GO:0071496,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1902494,GO:1903600	4.3.3.6	ko:K08681	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS19495	SNO
REGS1_k127_1513501_3	316274.Haur_2676	1.69e-39	154.0	COG1564@1|root,COG1564@2|Bacteria,2G6VK@200795|Chloroflexi,375VW@32061|Chloroflexia	32061|Chloroflexia	H	PFAM Thiamin pyrophosphokinase, catalytic region	-	-	2.7.6.2	ko:K00949	ko00730,ko01100,map00730,map01100	-	R00619	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	TPK_B1_binding,TPK_catalytic
REGS1_k127_1513501_4	926550.CLDAP_14700	6.354e-29	126.0	COG1825@1|root,COG1825@2|Bacteria,2G7A4@200795|Chloroflexi	200795|Chloroflexi	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	-	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
REGS1_k127_1513501_0	357808.RoseRS_3600	7.836e-94	330.0	COG1293@1|root,COG1293@2|Bacteria,2G5TC@200795|Chloroflexi,375AD@32061|Chloroflexia	32061|Chloroflexia	K	Fibronectin-binding A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF814,FbpA
REGS1_k127_1513501_2	926550.CLDAP_23250	1.602e-44	167.0	COG0500@1|root,COG2226@2|Bacteria,2G9CY@200795|Chloroflexi	200795|Chloroflexi	Q	Methyltransferase type 12	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
REGS1_k127_1527937_2	1205680.CAKO01000010_gene3723	6.915e-44	162.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2TRII@28211|Alphaproteobacteria,2JQ74@204441|Rhodospirillales	204441|Rhodospirillales	I	AMP-binding enzyme C-terminal domain	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
REGS1_k127_1527937_1	684949.ATTJ01000001_gene1944	3.129e-65	232.0	COG0639@1|root,COG0639@2|Bacteria	2|Bacteria	T	phosphoprotein phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos_2
REGS1_k127_1527937_0	926569.ANT_11560	5.754e-90	316.0	COG1269@1|root,COG1269@2|Bacteria	2|Bacteria	C	ATP hydrolysis coupled proton transport	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
REGS1_k127_1535140_1	479434.Sthe_1282	5.893e-28	121.0	COG0472@1|root,COG0472@2|Bacteria,2G6H5@200795|Chloroflexi,27Y1S@189775|Thermomicrobia	189775|Thermomicrobia	M	Glycosyl transferase family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_4
REGS1_k127_1535140_2	926550.CLDAP_10530	1.382e-12	80.0	COG0457@1|root,COG0823@1|root,COG0457@2|Bacteria,COG0823@2|Bacteria,2G8PZ@200795|Chloroflexi	200795|Chloroflexi	U	WD40 domain protein beta Propeller	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40
REGS1_k127_1535140_0	1123248.KB893314_gene3562	5.511e-65	233.0	COG1030@1|root,COG1030@2|Bacteria,4NGGV@976|Bacteroidetes,1IPJY@117747|Sphingobacteriia	976|Bacteroidetes	O	NfeD-like C-terminal, partner-binding	-	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	CLP_protease,NfeD
REGS1_k127_1538981_0	926550.CLDAP_03240	1.526e-73	259.0	COG1287@1|root,COG1287@2|Bacteria	2|Bacteria	S	oligosaccharyl transferase activity	-	-	2.4.99.18	ko:K07151	ko00510,ko00513,ko01100,ko04141,map00510,map00513,map01100,map04141	M00072	R04216,R05976	RC00005,RC00482	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT66	-	-
REGS1_k127_1538981_1	926550.CLDAP_03230	5.357e-10	67.0	COG5617@1|root,COG5617@2|Bacteria	2|Bacteria	M	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	PTPS_related,YfhO
REGS1_k127_1553278_1	926550.CLDAP_07480	4.783e-106	353.0	COG0568@1|root,COG0568@2|Bacteria,2G5W3@200795|Chloroflexi	200795|Chloroflexi	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
REGS1_k127_1553278_0	309801.trd_1549	7.614e-296	921.0	COG0556@1|root,COG0556@2|Bacteria,2G5SU@200795|Chloroflexi,27XME@189775|Thermomicrobia	189775|Thermomicrobia	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
REGS1_k127_1553278_7	1089551.KE386572_gene3918	4.788e-06	57.0	COG0662@1|root,COG0662@2|Bacteria,1R2AI@1224|Proteobacteria,2TZEX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Cupin	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
REGS1_k127_1553278_4	485913.Krac_7750	3.905e-29	121.0	COG1610@1|root,COG1610@2|Bacteria,2G7B8@200795|Chloroflexi	200795|Chloroflexi	S	Yqey-like protein	-	-	-	ko:K09117	-	-	-	-	ko00000	-	-	-	YqeY
REGS1_k127_1553278_3	379066.GAU_2760	5.851e-42	159.0	COG1986@1|root,COG1986@2|Bacteria,1ZUVB@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions	-	-	-	-	-	-	-	-	-	-	-	-	NTPase_I-T
REGS1_k127_1553278_6	401526.TcarDRAFT_2320	1.536e-06	58.0	COG4254@1|root,COG4254@2|Bacteria	2|Bacteria	UW	PFAM FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	FecR
REGS1_k127_1553278_5	68570.DC74_938	7.554e-11	74.0	COG0235@1|root,COG0235@2|Bacteria	2|Bacteria	G	Class ii aldolase	-	-	2.2.1.8,4.1.2.17	ko:K01628,ko:K18847	ko00051,ko01120,map00051,map01120	-	R02262	RC00603,RC00604	ko00000,ko00001,ko01000	-	-	-	Aldolase_II
REGS1_k127_1553278_2	1209989.TepiRe1_0381	5.812e-93	321.0	COG0534@1|root,COG0534@2|Bacteria,1TQMT@1239|Firmicutes,249WJ@186801|Clostridia,42FNE@68295|Thermoanaerobacterales	186801|Clostridia	V	PFAM multi antimicrobial extrusion protein MatE	-	-	-	-	-	-	-	-	-	-	-	-	MatE
REGS1_k127_1594508_0	118173.KB235914_gene221	2.292e-107	357.0	COG2046@1|root,COG2046@2|Bacteria,1G0E8@1117|Cyanobacteria,1H7XJ@1150|Oscillatoriales	1117|Cyanobacteria	P	Belongs to the sulfate adenylyltransferase family	sat	-	2.7.7.4	ko:K00958	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-sulfurylase,PUA_2
REGS1_k127_1594508_3	1382306.JNIM01000001_gene2710	7.499e-36	151.0	COG5542@1|root,COG5542@2|Bacteria,2G72S@200795|Chloroflexi	200795|Chloroflexi	S	integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	Mannosyl_trans2
REGS1_k127_1594508_2	1047013.AQSP01000131_gene1797	1.21e-78	272.0	COG0823@1|root,COG0823@2|Bacteria,2NPHZ@2323|unclassified Bacteria	2|Bacteria	U	WD40-like Beta Propeller Repeat	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40
REGS1_k127_1594508_1	765910.MARPU_14455	1.054e-93	328.0	COG3379@1|root,COG3379@2|Bacteria,1PWC6@1224|Proteobacteria,1TKB0@1236|Gammaproteobacteria,1X1DI@135613|Chromatiales	135613|Chromatiales	S	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
REGS1_k127_1594508_4	398512.JQKC01000025_gene3126	8.338e-06	49.0	COG2199@1|root,COG3706@2|Bacteria,1V9Y7@1239|Firmicutes,24A8B@186801|Clostridia,3WN7V@541000|Ruminococcaceae	186801|Clostridia	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
REGS1_k127_1614399_7	272558.10175033	1.193e-21	96.0	COG0532@1|root,COG0532@2|Bacteria,1TPAI@1239|Firmicutes,4HA8S@91061|Bacilli,1ZBWA@1386|Bacillus	91061|Bacilli	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
REGS1_k127_1614399_8	1449337.JQLL01000001_gene456	5.712e-16	83.0	COG0858@1|root,COG0858@2|Bacteria,1VA0P@1239|Firmicutes,4HII1@91061|Bacilli,27GDX@186828|Carnobacteriaceae	91061|Bacilli	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
REGS1_k127_1614399_4	580331.Thit_1185	2.08e-55	206.0	COG0618@1|root,COG0618@2|Bacteria,1TPXX@1239|Firmicutes,248R3@186801|Clostridia,42ER4@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM phosphoesterase, RecJ domain protein	nrnA	-	3.1.13.3,3.1.3.7	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
REGS1_k127_1614399_3	1123368.AUIS01000006_gene688	4.66e-68	242.0	COG0130@1|root,COG0130@2|Bacteria,1MV0N@1224|Proteobacteria,1RMKP@1236|Gammaproteobacteria,2NCPG@225057|Acidithiobacillales	225057|Acidithiobacillales	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	-	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB-C_2,TruB_C_2,TruB_N
REGS1_k127_1614399_2	324602.Caur_2955	6.345e-71	251.0	COG0196@1|root,COG0196@2|Bacteria,2G6JF@200795|Chloroflexi,374TG@32061|Chloroflexia	32061|Chloroflexia	H	TIGRFAM riboflavin biosynthesis protein RibF	-	-	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
REGS1_k127_1614399_5	1173028.ANKO01000166_gene4309	9.863e-33	131.0	COG1371@1|root,COG1371@2|Bacteria,1G81W@1117|Cyanobacteria,1HG37@1150|Oscillatoriales	1117|Cyanobacteria	S	Archease protein family (MTH1598/TM1083)	-	-	-	-	-	-	-	-	-	-	-	-	Archease
REGS1_k127_1614399_0	879212.DespoDRAFT_01391	5.968e-210	663.0	COG1690@1|root,COG1690@2|Bacteria,1MUHA@1224|Proteobacteria,42MZN@68525|delta/epsilon subdivisions,2WJGK@28221|Deltaproteobacteria,2MHPF@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Belongs to the RtcB family	rtcB	-	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
REGS1_k127_1614399_1	383372.Rcas_0660	1.955e-86	296.0	COG0303@1|root,COG0303@2|Bacteria,2G99Q@200795|Chloroflexi,3772N@32061|Chloroflexia	32061|Chloroflexia	H	PFAM molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	MoCF_biosynth
REGS1_k127_1614399_6	706587.Desti_4721	6.5e-27	114.0	2DZFA@1|root,32V98@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_1614399_9	1157490.EL26_07795	1.287e-09	59.0	COG1159@1|root,COG1159@2|Bacteria,1TP3R@1239|Firmicutes,4H9WF@91061|Bacilli,2788K@186823|Alicyclobacillaceae	91061|Bacilli	S	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism	era	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006275,GO:0008150,GO:0008156,GO:0009889,GO:0009890,GO:0009892,GO:0010556,GO:0010558,GO:0010605,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0019219,GO:0019222,GO:0030174,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032297,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0045934,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051302,GO:0051781,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0090329,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:2000104,GO:2000112,GO:2000113	-	ko:K03595	-	-	-	-	ko00000,ko03009,ko03029	-	-	-	KH_2,MMR_HSR1
REGS1_k127_1626184_1	1123405.AUMM01000034_gene1692	8.402e-47	178.0	COG0122@1|root,COG0122@2|Bacteria	2|Bacteria	L	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase	alkA	-	4.2.99.18	ko:K03660	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD,OGG_N
REGS1_k127_1626184_0	338963.Pcar_2900	1.733e-69	244.0	COG0084@1|root,COG0084@2|Bacteria,1R450@1224|Proteobacteria,42WEC@68525|delta/epsilon subdivisions	1224|Proteobacteria	L	TatD related DNase	-	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
REGS1_k127_1626184_2	1869.MB27_10525	2.14e-07	55.0	COG3871@1|root,COG3871@2|Bacteria,2I2TZ@201174|Actinobacteria	201174|Actinobacteria	S	pyridoxamine 5-phosphate	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Putative_PNPOx
REGS1_k127_1628118_0	635013.TherJR_2099	2.088e-208	674.0	COG1200@1|root,COG1200@2|Bacteria,1TQ6I@1239|Firmicutes,247T0@186801|Clostridia,260I6@186807|Peptococcaceae	186801|Clostridia	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
REGS1_k127_1628118_3	525904.Tter_1651	1.79e-70	248.0	COG1307@1|root,COG1307@2|Bacteria,2NQTE@2323|unclassified Bacteria	2|Bacteria	S	Uncharacterised protein, DegV family COG1307	degV	-	-	-	-	-	-	-	-	-	-	-	DegV
REGS1_k127_1628118_4	316274.Haur_0364	4.398e-64	230.0	COG1307@1|root,COG1307@2|Bacteria,2G6P2@200795|Chloroflexi,374VJ@32061|Chloroflexia	32061|Chloroflexia	S	PFAM DegV family protein	-	-	-	-	-	-	-	-	-	-	-	-	DegV
REGS1_k127_1628118_1	1382306.JNIM01000001_gene214	2.05e-140	465.0	COG1461@1|root,COG1461@2|Bacteria,2G61Z@200795|Chloroflexi	200795|Chloroflexi	S	PFAM Dak phosphatase	-	-	-	ko:K07030	-	-	-	-	ko00000	-	-	-	Dak1_2,Dak2
REGS1_k127_1628118_7	1128421.JAGA01000002_gene199	2.54e-30	124.0	COG1302@1|root,COG1302@2|Bacteria	2|Bacteria	M	Protein conserved in bacteria	asp	-	-	-	-	-	-	-	-	-	-	-	Asp23
REGS1_k127_1628118_5	1123284.KB899042_gene1343	5.012e-53	191.0	COG1970@1|root,COG1970@2|Bacteria,1VA14@1239|Firmicutes,4HKIA@91061|Bacilli,26PZ3@186821|Sporolactobacillaceae	91061|Bacilli	M	Large-conductance mechanosensitive channel, MscL	mscL	GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0032535,GO:0042592,GO:0044425,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0090066	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
REGS1_k127_1628118_9	1304888.ATWF01000002_gene363	1.161e-11	66.0	COG0227@1|root,COG0227@2|Bacteria,2GG02@200930|Deferribacteres	200930|Deferribacteres	J	Ribosomal L28 family	rpmB	-	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
REGS1_k127_1628118_2	1033734.CAET01000018_gene712	4.441e-82	278.0	COG0036@1|root,COG0036@2|Bacteria,1TQK8@1239|Firmicutes,4H9RW@91061|Bacilli,1ZCUF@1386|Bacillus	91061|Bacilli	G	Belongs to the ribulose-phosphate 3-epimerase family	rpe	GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046496,GO:0046872,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
REGS1_k127_1628118_6	99598.Cal7507_0697	1.491e-52	189.0	2DQ25@1|root,334FF@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_1628118_8	926550.CLDAP_41040	3.627e-24	114.0	COG5305@1|root,COG5305@2|Bacteria,2G7EE@200795|Chloroflexi	2|Bacteria	S	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
REGS1_k127_1688993_4	1218075.BAYA01000046_gene6673	1.944e-50	183.0	COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2VHII@28216|Betaproteobacteria,1KIDY@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase	-	-	1.3.99.16	ko:K00256	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
REGS1_k127_1688993_0	926569.ANT_11040	1.155e-158	519.0	COG0441@1|root,COG0572@1|root,COG0441@2|Bacteria,COG0572@2|Bacteria,2G9NH@200795|Chloroflexi	200795|Chloroflexi	F	Phosphoribulokinase / Uridine kinase family	-	-	2.7.1.48	ko:K00876	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PRK
REGS1_k127_1688993_6	1382359.JIAL01000001_gene2414	9.045e-34	132.0	COG1146@1|root,COG1146@2|Bacteria,3Y59N@57723|Acidobacteria,2JJRG@204432|Acidobacteriia	204432|Acidobacteriia	C	4Fe-4S dicluster domain	-	-	-	ko:K05524	-	-	-	-	ko00000	-	-	-	Fer4,Fer4_4
REGS1_k127_1688993_5	1120973.AQXL01000035_gene3094	6.611e-43	164.0	COG1309@1|root,COG1309@2|Bacteria,1V3QD@1239|Firmicutes,4IQ6R@91061|Bacilli,27AQ7@186823|Alicyclobacillaceae	91061|Bacilli	K	YsiA-like protein, C-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_4,TetR_N
REGS1_k127_1688993_8	1200792.AKYF01000010_gene1908	2.17e-09	65.0	COG0526@1|root,COG0526@2|Bacteria,1VAPY@1239|Firmicutes,4HIQ3@91061|Bacilli,274A1@186822|Paenibacillaceae	91061|Bacilli	CO	Thioredoxin-like	resA	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
REGS1_k127_1688993_3	1123405.AUMM01000028_gene1406	7.55e-66	233.0	COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,4HAA6@91061|Bacilli,26N9U@186821|Sporolactobacillaceae	91061|Bacilli	IQ	PFAM short-chain dehydrogenase reductase SDR	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
REGS1_k127_1688993_1	1385513.N780_06200	3.687e-107	361.0	COG0183@1|root,COG0183@2|Bacteria,1TP07@1239|Firmicutes,4H9RJ@91061|Bacilli,2Y8N8@289201|Pontibacillus	91061|Bacilli	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
REGS1_k127_1688993_2	760568.Desku_2349	2.089e-94	321.0	COG1804@1|root,COG1804@2|Bacteria,1TP54@1239|Firmicutes,24AFB@186801|Clostridia,2607C@186807|Peptococcaceae	186801|Clostridia	C	PFAM CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
REGS1_k127_1688993_7	1145276.T479_17185	2.003e-27	115.0	COG1024@1|root,COG1024@2|Bacteria,1TQ89@1239|Firmicutes,4HB73@91061|Bacilli,3IWPE@400634|Lysinibacillus	91061|Bacilli	I	Belongs to the enoyl-CoA hydratase isomerase family	fadB	GO:0003674,GO:0003824,GO:0004300,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575	4.2.1.17	ko:K13767	ko00071,ko00362,ko01100,ko01120,ko01212,map00071,map00362,map01100,map01120,map01212	M00087	R03026,R04170,R04738,R04740,R04744,R04746	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
REGS1_k127_1696993_0	1120973.AQXL01000068_gene20	1.956e-74	264.0	COG0683@1|root,COG0683@2|Bacteria,1TPQ2@1239|Firmicutes,4HAE3@91061|Bacilli	91061|Bacilli	E	ABC transporter (Permease	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
REGS1_k127_1696993_1	1382306.JNIM01000001_gene1025	3.338e-32	129.0	COG1541@1|root,COG1541@2|Bacteria,2G695@200795|Chloroflexi	200795|Chloroflexi	H	AMP-binding enzyme	-	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
REGS1_k127_1705071_3	1089548.KI783301_gene465	4.588e-84	285.0	COG0247@1|root,COG0247@2|Bacteria,1TPFC@1239|Firmicutes,4HAKC@91061|Bacilli,3WF6V@539002|Bacillales incertae sedis	91061|Bacilli	C	Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source	lutA	-	-	ko:K18928	-	-	-	-	ko00000	-	-	-	CCG
REGS1_k127_1705071_0	1128421.JAGA01000003_gene3367	4.725e-148	482.0	COG1139@1|root,COG1139@2|Bacteria,2NQQF@2323|unclassified Bacteria	2|Bacteria	C	LUD domain	lutB	-	-	ko:K18929	-	-	-	-	ko00000	-	-	iSF_1195.SF0259,iSFxv_1172.SFxv_0274,iS_1188.S0280	DUF3390,Fer4_8,LUD_dom
REGS1_k127_1705071_4	266117.Rxyl_2993	8.451e-25	113.0	COG1556@1|root,COG1556@2|Bacteria,2GY0B@201174|Actinobacteria	201174|Actinobacteria	S	LUD domain	-	-	-	ko:K00782	-	-	-	-	ko00000	-	-	-	LUD_dom
REGS1_k127_1705071_2	479434.Sthe_1760	1.167e-93	314.0	COG3959@1|root,COG3959@2|Bacteria,2GA6J@200795|Chloroflexi,27XHY@189775|Thermomicrobia	189775|Thermomicrobia	G	XFP N-terminal domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
REGS1_k127_1705071_1	1382356.JQMP01000004_gene545	4.229e-111	367.0	COG3958@1|root,COG3958@2|Bacteria,2G8E1@200795|Chloroflexi,27XY5@189775|Thermomicrobia	189775|Thermomicrobia	G	Transketolase, pyrimidine binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
REGS1_k127_1719568_1	1121422.AUMW01000028_gene3403	2.467e-35	138.0	COG0421@1|root,COG0421@2|Bacteria,1TPG5@1239|Firmicutes,24827@186801|Clostridia,260Q6@186807|Peptococcaceae	186801|Clostridia	H	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	speE	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synt_N,Spermine_synth
REGS1_k127_1719568_3	711393.AYRX01000082_gene4873	3.832e-05	54.0	COG0500@1|root,COG2226@2|Bacteria,2GK7A@201174|Actinobacteria	201174|Actinobacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_31
REGS1_k127_1719568_0	357808.RoseRS_1979	1.212e-248	779.0	COG0173@1|root,COG0173@2|Bacteria,2G5RX@200795|Chloroflexi,374WK@32061|Chloroflexia	32061|Chloroflexia	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
REGS1_k127_1719568_2	525903.Taci_0751	1.675e-07	57.0	COG1994@1|root,COG1994@2|Bacteria,3TAT7@508458|Synergistetes	508458|Synergistetes	S	PFAM Peptidase family M50	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
REGS1_k127_173308_4	32049.SYNPCC7002_A0258	3.074e-07	56.0	COG1357@1|root,COG1357@2|Bacteria,1G1VX@1117|Cyanobacteria,1H2S9@1129|Synechococcus	1117|Cyanobacteria	S	Pentapeptide repeats (9 copies)	-	-	-	-	-	-	-	-	-	-	-	-	Pentapeptide
REGS1_k127_173308_2	765420.OSCT_1557	4.585e-91	314.0	COG1079@1|root,COG1079@2|Bacteria,2G6BT@200795|Chloroflexi,374T2@32061|Chloroflexia	32061|Chloroflexia	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
REGS1_k127_173308_1	1128421.JAGA01000002_gene341	1.841e-93	323.0	COG4603@1|root,COG4603@2|Bacteria	2|Bacteria	L	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
REGS1_k127_173308_0	867845.KI911784_gene2333	2.073e-198	630.0	COG3845@1|root,COG3845@2|Bacteria,2G625@200795|Chloroflexi,374YV@32061|Chloroflexia	32061|Chloroflexia	S	PFAM ABC transporter related	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
REGS1_k127_173308_3	357808.RoseRS_1320	2.561e-09	58.0	COG1744@1|root,COG1744@2|Bacteria,2G6UB@200795|Chloroflexi,375H7@32061|Chloroflexia	32061|Chloroflexia	M	PFAM basic membrane lipoprotein	-	-	-	ko:K07335	-	-	-	-	ko00000	-	-	-	Bmp
REGS1_k127_1848836_3	1463861.JNXE01000002_gene6275	6.199e-06	58.0	COG2182@1|root,COG2182@2|Bacteria	2|Bacteria	G	maltose binding	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
REGS1_k127_1848836_0	644282.Deba_0199	4.599e-81	290.0	COG1215@1|root,COG1215@2|Bacteria,1QVA1@1224|Proteobacteria,43BP8@68525|delta/epsilon subdivisions,2X70I@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	PFAM Glycosyl transferase family 2	-	-	2.4.1.268	ko:K21349	-	-	-	-	ko00000,ko01000	-	GT81	-	Glycos_transf_2
REGS1_k127_1848836_2	926569.ANT_19460	2.605e-28	120.0	COG3088@1|root,COG3088@2|Bacteria,2G72W@200795|Chloroflexi	200795|Chloroflexi	O	subunit of a heme lyase	ccmH	-	-	ko:K02200	-	-	-	-	ko00000	-	-	-	CcmH
REGS1_k127_1848836_1	926550.CLDAP_40040	8.026e-43	166.0	COG0526@1|root,COG0526@2|Bacteria,2G737@200795|Chloroflexi	200795|Chloroflexi	CO	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	-	ko:K02199	-	-	-	-	ko00000,ko03110	-	-	-	AhpC-TSA,DnaJ
REGS1_k127_1889449_2	1128421.JAGA01000002_gene879	3.184e-80	277.0	COG0318@1|root,COG0318@2|Bacteria,2NPH9@2323|unclassified Bacteria	2|Bacteria	IQ	COGs COG0318 Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II	fadD	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
REGS1_k127_1889449_5	463191.SSEG_07584	6.133e-09	63.0	COG0526@1|root,COG0526@2|Bacteria,2GP7J@201174|Actinobacteria	201174|Actinobacteria	CO	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	resA	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
REGS1_k127_1889449_3	1123392.AQWL01000005_gene2891	1.08e-20	91.0	COG0545@1|root,COG0545@2|Bacteria,1RDA1@1224|Proteobacteria,2VSIG@28216|Betaproteobacteria,1KRW4@119069|Hydrogenophilales	119069|Hydrogenophilales	O	FKBP-type peptidyl-prolyl cis-trans isomerase	-	-	5.2.1.8	ko:K03772	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C
REGS1_k127_1889449_4	575540.Isop_1727	2.551e-18	85.0	COG0545@1|root,COG0545@2|Bacteria,2J3IN@203682|Planctomycetes	203682|Planctomycetes	O	FKBP-type peptidyl-prolyl cis-trans isomerase	-	-	5.2.1.8	ko:K01802	-	-	-	-	ko00000,ko01000	-	-	-	FKBP_C
REGS1_k127_1889449_1	383372.Rcas_0160	2.227e-177	564.0	COG0192@1|root,COG0192@2|Bacteria,2G5X0@200795|Chloroflexi,37571@32061|Chloroflexia	32061|Chloroflexia	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
REGS1_k127_1889449_0	926569.ANT_16170	2.751e-203	640.0	COG0499@1|root,COG0499@2|Bacteria,2G5X8@200795|Chloroflexi	200795|Chloroflexi	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
REGS1_k127_1895326_0	671143.DAMO_0766	3.153e-154	505.0	COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,2NNUW@2323|unclassified Bacteria	2|Bacteria	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	pcmB	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6,1.97.1.9	ko:K03388,ko:K12527	ko00450,ko00680,ko01100,ko01120,ko01200,map00450,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R07229,R11928,R11931,R11943,R11944	RC00011,RC02420	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_20,FlpD,Pyr_redox_2,Pyr_redox_3
REGS1_k127_1895326_1	485913.Krac_6667	9.667e-89	299.0	COG1290@1|root,COG1290@2|Bacteria,2G8QQ@200795|Chloroflexi	200795|Chloroflexi	C	Cytochrome b(N-terminal)/b6/petB	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_B
REGS1_k127_190852_6	383372.Rcas_0960	8.326e-89	298.0	COG0745@1|root,COG0745@2|Bacteria,2G85S@200795|Chloroflexi,375HI@32061|Chloroflexia	32061|Chloroflexia	K	Two component transcriptional regulator, winged helix family	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
REGS1_k127_190852_4	1128421.JAGA01000003_gene3536	9.86e-108	367.0	COG5002@1|root,COG5002@2|Bacteria,2NS5D@2323|unclassified Bacteria	2|Bacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	2.7.13.3	ko:K02484,ko:K07642	ko02020,map02020	M00450,M00645,M00646,M00648	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
REGS1_k127_190852_1	1128421.JAGA01000002_gene1080	4.523e-134	440.0	COG2133@1|root,COG2133@2|Bacteria,2NNSP@2323|unclassified Bacteria	2|Bacteria	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	CBM_2,GSDH
REGS1_k127_190852_2	926569.ANT_18200	1.956e-133	435.0	COG0489@1|root,COG0489@2|Bacteria,2G60P@200795|Chloroflexi	200795|Chloroflexi	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	-	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	FeS_assembly_P,ParA
REGS1_k127_190852_8	665571.STHERM_c06620	1.297e-06	55.0	COG0457@1|root,COG0457@2|Bacteria,2J5NB@203691|Spirochaetes	203691|Spirochaetes	S	tetratricopeptide repeat	lmp1	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_2,TPR_6,TPR_7,TPR_8
REGS1_k127_190852_0	867845.KI911784_gene1240	9.993e-213	670.0	COG1027@1|root,COG1027@2|Bacteria,2G5IV@200795|Chloroflexi,37644@32061|Chloroflexia	32061|Chloroflexia	C	PFAM fumarate lyase	-	-	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
REGS1_k127_190852_5	1382304.JNIL01000001_gene3207	1.034e-94	313.0	COG0605@1|root,COG0605@2|Bacteria,1TPXT@1239|Firmicutes,4HA6U@91061|Bacilli,2781X@186823|Alicyclobacillaceae	91061|Bacilli	P	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	sodA	-	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
REGS1_k127_190852_3	1118054.CAGW01000080_gene2776	1.266e-110	369.0	COG1071@1|root,COG1071@2|Bacteria,1TQDG@1239|Firmicutes,4HBEQ@91061|Bacilli,26TZ7@186822|Paenibacillaceae	91061|Bacilli	C	Dehydrogenase E1 component	bfmBAA	-	1.2.4.4	ko:K00166	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iSB619.SA_RS07640	E1_dh
REGS1_k127_190852_7	1089548.KI783301_gene1755	9.327e-54	191.0	COG0022@1|root,COG0022@2|Bacteria,1TP3J@1239|Firmicutes,4HA4H@91061|Bacilli,3WG36@539002|Bacillales incertae sedis	91061|Bacilli	C	Transketolase, pyrimidine binding domain	-	-	1.2.4.1	ko:K00162,ko:K21417	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
REGS1_k127_1909809_4	309798.COPRO5265_1254	9.053e-09	58.0	COG3350@1|root,COG3350@2|Bacteria	2|Bacteria	T	monooxygenase activity	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	DUF2318,YHS
REGS1_k127_1909809_3	795359.TOPB45_0125	5.141e-17	86.0	2DPS5@1|root,3335G@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2703
REGS1_k127_1909809_0	472759.Nhal_2157	3.655e-289	902.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,1WVXM@135613|Chromatiales	135613|Chromatiales	P	heavy metal translocating P-type ATPase	-	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
REGS1_k127_1909809_2	552811.Dehly_1279	6.202e-25	110.0	COG2010@1|root,COG2010@2|Bacteria,2G9FK@200795|Chloroflexi	200795|Chloroflexi	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_1909809_1	1041930.Mtc_2416	7.304e-214	683.0	COG2217@1|root,arCOG02763@1|root,arCOG01576@2157|Archaea,arCOG02763@2157|Archaea,2XT3T@28890|Euryarchaeota,2N94W@224756|Methanomicrobia	224756|Methanomicrobia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	copA	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
REGS1_k127_1958219_0	316274.Haur_2192	9.761e-90	323.0	COG5295@1|root,COG5295@2|Bacteria,2GB82@200795|Chloroflexi,377IZ@32061|Chloroflexia	32061|Chloroflexia	UW	Hep Hag repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	Pectinesterase
REGS1_k127_1958219_2	596319.STAWA0001_0522	7.529e-06	59.0	COG4932@1|root,COG4932@2|Bacteria,1VSCD@1239|Firmicutes,4HV6Y@91061|Bacilli,4H18Q@90964|Staphylococcaceae	91061|Bacilli	M	Cna protein B-type domain	-	-	-	ko:K14194	ko05150,map05150	-	-	-	ko00000,ko00001	-	-	-	Gram_pos_anchor,SdrD_B,SdrG_C_C,YSIRK_signal
REGS1_k127_1958219_1	1382356.JQMP01000003_gene2493	4.756e-10	73.0	COG1595@1|root,COG1595@2|Bacteria,2GBDV@200795|Chloroflexi,27Z17@189775|Thermomicrobia	189775|Thermomicrobia	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2
REGS1_k127_197087_1	479434.Sthe_3074	5.667e-10	62.0	COG1011@1|root,COG1011@2|Bacteria,2G74Q@200795|Chloroflexi	200795|Chloroflexi	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
REGS1_k127_197087_2	215803.DB30_1947	8.426e-09	66.0	2DY29@1|root,32V4J@2|Bacteria,1P2QH@1224|Proteobacteria,43F3S@68525|delta/epsilon subdivisions,2X9U6@28221|Deltaproteobacteria,2YV4T@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_197087_0	765420.OSCT_2101	4.311e-151	489.0	COG2303@1|root,COG2303@2|Bacteria,2G7EB@200795|Chloroflexi	200795|Chloroflexi	E	GMC oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N
REGS1_k127_198789_5	926569.ANT_16410	2.551e-18	85.0	COG0739@1|root,COG1388@1|root,COG0739@2|Bacteria,COG1388@2|Bacteria,2G901@200795|Chloroflexi	200795|Chloroflexi	M	Lysin motif	-	-	-	-	-	-	-	-	-	-	-	-	LysM,Peptidase_M23
REGS1_k127_198789_4	1123371.ATXH01000027_gene160	1.43e-23	104.0	COG0261@1|root,COG0261@2|Bacteria,2GHY6@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	J	This protein binds to 23S rRNA in the presence of protein L20	rplU	-	-	ko:K02888	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21p
REGS1_k127_198789_2	309801.trd_1425	6.406e-36	138.0	COG0211@1|root,COG0211@2|Bacteria,2G7BE@200795|Chloroflexi,27YJD@189775|Thermomicrobia	189775|Thermomicrobia	J	Belongs to the bacterial ribosomal protein bL27 family	rpmA	-	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
REGS1_k127_198789_3	324602.Caur_2316	3.386e-24	107.0	COG0254@1|root,COG0254@2|Bacteria,2G75A@200795|Chloroflexi,375Y4@32061|Chloroflexia	32061|Chloroflexia	J	Binds the 23S rRNA	rpmE	-	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
REGS1_k127_198789_1	316274.Haur_2667	6.631e-75	257.0	COG1435@1|root,COG1435@2|Bacteria,2G6DP@200795|Chloroflexi,375P5@32061|Chloroflexia	32061|Chloroflexia	F	PFAM thymidine kinase	tdk	GO:0003674,GO:0003824,GO:0004797,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006259,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009120,GO:0009123,GO:0009124,GO:0009157,GO:0009162,GO:0009165,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0018130,GO:0019136,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046104,GO:0046125,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0090304,GO:0090407,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657	2.7.1.21	ko:K00857	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01567,R02099,R08233	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	TK
REGS1_k127_198789_0	926550.CLDAP_31820	2.779e-118	406.0	COG5617@1|root,COG5617@2|Bacteria	2|Bacteria	M	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_1995343_2	1382306.JNIM01000001_gene331	2.367e-13	70.0	COG2057@1|root,COG2057@2|Bacteria,2G6MS@200795|Chloroflexi	200795|Chloroflexi	I	Coenzyme A transferase	-	-	2.8.3.12	ko:K01040	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
REGS1_k127_1995343_0	42256.RradSPS_1677	2.332e-161	521.0	COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria,4CRW6@84995|Rubrobacteria	84995|Rubrobacteria	C	Aldehyde dehydrogenase family	-	-	1.2.1.16,1.2.1.20,1.2.1.79	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	M00027	R00713,R00714,R02401	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
REGS1_k127_1995343_1	266117.Rxyl_1760	3.126e-103	340.0	COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria,4CRW6@84995|Rubrobacteria	84995|Rubrobacteria	C	Aldehyde dehydrogenase family	-	-	1.2.1.16,1.2.1.20,1.2.1.79	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	M00027	R00713,R00714,R02401	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
REGS1_k127_2017131_0	515635.Dtur_1626	4.175e-43	173.0	COG0419@1|root,COG0419@2|Bacteria	2|Bacteria	L	ATPase involved in DNA repair	sbcC	-	-	ko:K03546	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,Rad50_zn_hook,SMC_N,SbcCD_C
REGS1_k127_2017131_2	324925.Ppha_1113	3.149e-26	112.0	2ESXY@1|root,33KG8@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_2017131_1	309801.trd_A0609	2.818e-41	162.0	COG2353@1|root,COG2353@2|Bacteria,2G73S@200795|Chloroflexi,27Z4A@189775|Thermomicrobia	189775|Thermomicrobia	S	YceI-like domain	-	-	-	-	-	-	-	-	-	-	-	-	YceI
REGS1_k127_2019370_2	479434.Sthe_1657	1.896e-89	301.0	COG0648@1|root,COG0648@2|Bacteria,2G5XZ@200795|Chloroflexi,27XEG@189775|Thermomicrobia	189775|Thermomicrobia	L	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin	nfo	-	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
REGS1_k127_2019370_1	1265310.CCBD010000064_gene1070	1.609e-156	528.0	COG2114@1|root,COG2197@1|root,COG3903@1|root,COG2114@2|Bacteria,COG2197@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria,233DM@1762|Mycobacteriaceae	201174|Actinobacteria	K	involved in signal transduction (via phosphorylation) involved in transcriptional regulatory mechanism and in the regulation of secondary metabolites catalytic activity ATP a protein ADP a phosphoprotein	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Guanylate_cyc,NB-ARC
REGS1_k127_2019370_3	316274.Haur_2320	5.716e-49	181.0	COG1670@1|root,COG1670@2|Bacteria,2G9NS@200795|Chloroflexi	200795|Chloroflexi	J	COGs COG1670 Acetyltransferase including N-acetylase of ribosomal protein	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
REGS1_k127_2019370_0	1396418.BATQ01000184_gene2632	3.171e-197	633.0	COG2114@1|root,COG3903@1|root,COG2114@2|Bacteria,COG3903@2|Bacteria,46TZ3@74201|Verrucomicrobia	74201|Verrucomicrobia	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,NB-ARC
REGS1_k127_2039477_0	1123386.AUIW01000005_gene1563	1.932e-148	480.0	COG1053@1|root,COG1053@2|Bacteria,1WIYZ@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	succinate dehydrogenase or fumarate reductase, flavoprotein	sdhA	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
REGS1_k127_2039477_1	867903.ThesuDRAFT_00388	6.239e-23	99.0	COG0479@1|root,COG0479@2|Bacteria,1TP17@1239|Firmicutes,24AN0@186801|Clostridia	186801|Clostridia	C	TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein	-	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_8
REGS1_k127_2063862_1	525904.Tter_1681	9.732e-48	190.0	COG2843@1|root,COG3103@1|root,COG2843@2|Bacteria,COG4991@2|Bacteria,2NPJI@2323|unclassified Bacteria	2|Bacteria	M	Bacterial capsule synthesis protein PGA_cap	-	-	2.7.11.1	ko:K07282,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PGA_cap,SH3_3,SH3_4
REGS1_k127_2063862_0	479434.Sthe_1201	9.652e-110	363.0	COG1960@1|root,COG1960@2|Bacteria,2G5K3@200795|Chloroflexi,27YYB@189775|Thermomicrobia	189775|Thermomicrobia	C	acyl-CoA dehydrogenase	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
REGS1_k127_2074101_10	498761.HM1_0352	3.662e-17	87.0	COG1234@1|root,COG1234@2|Bacteria,1VDRF@1239|Firmicutes	1239|Firmicutes	S	Metallo-beta-lactamase superfamily	-	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
REGS1_k127_2074101_4	926569.ANT_09930	3.82e-101	347.0	COG1300@1|root,COG1668@1|root,COG1300@2|Bacteria,COG1668@2|Bacteria,2G8CN@200795|Chloroflexi	200795|Chloroflexi	CP	Stage II sporulation protein M	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane,ABC2_membrane_2,SpoIIM
REGS1_k127_2074101_5	1128421.JAGA01000002_gene12	4.758e-97	326.0	COG1131@1|root,COG1131@2|Bacteria,2NPDQ@2323|unclassified Bacteria	2|Bacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
REGS1_k127_2074101_13	1500306.JQLA01000002_gene1588	1.21e-09	70.0	COG0823@1|root,COG0823@2|Bacteria,1R5P1@1224|Proteobacteria,2U0ZV@28211|Alphaproteobacteria,4B8F5@82115|Rhizobiaceae	28211|Alphaproteobacteria	U	Periplasmic component of the Tol biopolymer transport system	tolB2	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,PD40
REGS1_k127_2074101_11	926550.CLDAP_26450	1.679e-12	80.0	COG3103@1|root,COG3103@2|Bacteria,COG4991@2|Bacteria	2|Bacteria	T	sh3 domain protein	-	-	2.7.11.1,3.4.21.107,3.5.1.28	ko:K01448,ko:K04771,ko:K08884	ko01503,ko02020,map01503,map02020	M00727,M00728	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01001,ko01002,ko01011,ko03036,ko03110	-	-	-	SH3_3
REGS1_k127_2074101_9	525904.Tter_0136	3.347e-19	102.0	COG0823@1|root,COG0823@2|Bacteria,2NPHZ@2323|unclassified Bacteria	2|Bacteria	U	WD40-like Beta Propeller Repeat	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40
REGS1_k127_2074101_7	204669.Acid345_1507	9.682e-58	209.0	COG0730@1|root,COG0730@2|Bacteria,3Y4IM@57723|Acidobacteria	57723|Acidobacteria	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
REGS1_k127_2074101_3	1209989.TepiRe1_0932	7.194e-134	437.0	COG0626@1|root,COG0626@2|Bacteria,1TPC7@1239|Firmicutes,25E6I@186801|Clostridia	186801|Clostridia	E	PFAM Cys Met metabolism	megL	-	2.5.1.48,4.4.1.11	ko:K01739,ko:K01761	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00654,R00999,R01288,R02508,R03217,R03260,R04770,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00196,RC00348,RC00420,RC01209,RC01210,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
REGS1_k127_2074101_1	525904.Tter_0248	1.287e-149	496.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,2NNS9@2323|unclassified Bacteria	2|Bacteria	EU	peptidase S9 prolyl oligopeptidase active site	-	-	-	-	-	-	-	-	-	-	-	-	DPPIV_N,PD40,Peptidase_S9
REGS1_k127_2074101_2	1499967.BAYZ01000036_gene2419	2.448e-148	476.0	COG2152@1|root,COG2152@2|Bacteria,2NPB8@2323|unclassified Bacteria	2|Bacteria	G	beta-1,4-mannooligosaccharide phosphorylase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_130
REGS1_k127_2074101_0	518766.Rmar_1363	1.6e-322	1004.0	COG0438@1|root,COG0438@2|Bacteria,4NEW7@976|Bacteroidetes	976|Bacteroidetes	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
REGS1_k127_2074101_6	671143.DAMO_2120	1.035e-60	229.0	COG0745@1|root,COG2202@1|root,COG2203@1|root,COG4191@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG4191@2|Bacteria,2NQ9F@2323|unclassified Bacteria	2|Bacteria	T	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HAMP,HATPase_c,HisKA,PAS_4,PAS_8,PAS_9,Response_reg
REGS1_k127_2074101_12	47763.JNZA01000012_gene6502	2.093e-11	76.0	COG2340@1|root,COG2340@2|Bacteria,2I39U@201174|Actinobacteria	201174|Actinobacteria	S	Cysteine-rich secretory protein family	-	-	-	-	-	-	-	-	-	-	-	-	CAP
REGS1_k127_2074101_8	1382306.JNIM01000001_gene3668	2.867e-22	107.0	COG0454@1|root,COG0456@2|Bacteria,2G9G9@200795|Chloroflexi	200795|Chloroflexi	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
REGS1_k127_209389_2	42256.RradSPS_1253	1.749e-07	55.0	COG1811@1|root,COG1811@2|Bacteria,2GM75@201174|Actinobacteria,4CQAW@84995|Rubrobacteria	84995|Rubrobacteria	S	Protein of unknown function (DUF554)	-	-	-	ko:K07150	-	-	-	-	ko00000	-	-	-	DUF554
REGS1_k127_209389_0	1121468.AUBR01000045_gene1802	3.342e-120	399.0	COG1228@1|root,COG1228@2|Bacteria,1TP2J@1239|Firmicutes,24AGR@186801|Clostridia,42EXG@68295|Thermoanaerobacterales	186801|Clostridia	F	Belongs to the metallo-dependent hydrolases superfamily. HutI family	hutI	-	3.5.2.7	ko:K01468	ko00340,ko01100,map00340,map01100	M00045	R02288	RC00683	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
REGS1_k127_209389_1	485913.Krac_7111	1.418e-10	74.0	COG2723@1|root,COG2723@2|Bacteria	2|Bacteria	G	beta-glucosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Cellulase,Glyco_hydro_1
REGS1_k127_2093891_2	1128421.JAGA01000002_gene799	1.041e-24	109.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1,Methyltransf_11,Methyltransf_23
REGS1_k127_2093891_0	1128421.JAGA01000002_gene800	2.245e-124	409.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1,Glycos_transf_2,Methyltransf_11
REGS1_k127_2093891_1	867845.KI911784_gene1969	1.009e-115	378.0	COG0451@1|root,COG0451@2|Bacteria,2G6ET@200795|Chloroflexi,375HU@32061|Chloroflexia	32061|Chloroflexia	M	short-chain dehydrogenase reductase SDR	-	-	5.1.3.10	ko:K12454	ko00520,map00520	-	R04266	RC00528	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
REGS1_k127_2116932_4	1489678.RDMS_10970	1.319e-18	87.0	COG1028@1|root,COG1028@2|Bacteria,1WMB5@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
REGS1_k127_2116932_1	316274.Haur_3457	7.841e-117	399.0	COG3118@1|root,COG3118@2|Bacteria,2G8FS@200795|Chloroflexi	200795|Chloroflexi	O	Arylsulfotransferase (ASST)	-	-	-	-	-	-	-	-	-	-	-	-	Arylsulfotran_2
REGS1_k127_2116932_3	926550.CLDAP_03560	1.292e-68	244.0	COG2120@1|root,COG2120@2|Bacteria,2G6FB@200795|Chloroflexi	200795|Chloroflexi	S	PFAM LmbE family protein	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
REGS1_k127_2116932_0	926569.ANT_05220	2.323e-223	707.0	COG0405@1|root,COG0405@2|Bacteria,2G5R2@200795|Chloroflexi	200795|Chloroflexi	E	PFAM Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
REGS1_k127_2116932_2	478741.JAFS01000002_gene125	5.081e-81	280.0	COG0389@1|root,COG0389@2|Bacteria,46SNK@74201|Verrucomicrobia,37GBB@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
REGS1_k127_2125569_1	330214.NIDE0322	1.597e-15	81.0	COG4398@1|root,COG4398@2|Bacteria	2|Bacteria	E	FIST C domain	-	GO:0008150,GO:0040007	-	-	-	-	-	-	-	-	-	-	FIST,FIST_C
REGS1_k127_2125569_0	1121918.ARWE01000001_gene385	1.397e-168	540.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,42MFC@68525|delta/epsilon subdivisions,2WTRK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Aminotransferase class-III	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_3
REGS1_k127_2125569_2	1121440.AUMA01000016_gene113	9.953e-08	61.0	COG0457@1|root,COG0457@2|Bacteria,1N0Q1@1224|Proteobacteria,42TBT@68525|delta/epsilon subdivisions,2WQ96@28221|Deltaproteobacteria,2MCPE@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	SMART Tetratricopeptide	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_2,TPR_6,TPR_8
REGS1_k127_214307_2	357808.RoseRS_3973	5.073e-13	72.0	COG1413@1|root,COG1413@2|Bacteria,2G6MW@200795|Chloroflexi,375QB@32061|Chloroflexia	32061|Chloroflexia	C	PBS lyase HEAT domain protein repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
REGS1_k127_214307_0	326427.Cagg_0536	2.34e-41	158.0	COG1468@1|root,COG1468@2|Bacteria,2G6VA@200795|Chloroflexi,375P8@32061|Chloroflexia	32061|Chloroflexia	L	Domain of unknown function DUF83	-	-	3.1.12.1	ko:K07464	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	Cas_Cas4
REGS1_k127_214307_1	748247.AZKH_p0139	2.798e-26	113.0	COG1051@1|root,COG1051@2|Bacteria,1QVI6@1224|Proteobacteria,2WGSD@28216|Betaproteobacteria,2KY2Q@206389|Rhodocyclales	206389|Rhodocyclales	F	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
REGS1_k127_2215982_2	479434.Sthe_1169	9.486e-49	185.0	COG0566@1|root,COG0566@2|Bacteria,2G6MC@200795|Chloroflexi,27YC9@189775|Thermomicrobia	189775|Thermomicrobia	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	-	-	-	ko:K03437	-	-	-	-	ko00000,ko03016	-	-	-	SpoU_methylase,SpoU_sub_bind
REGS1_k127_2215982_3	644966.Tmar_0828	1.091e-36	142.0	COG0292@1|root,COG0292@2|Bacteria,1V6DB@1239|Firmicutes,24JBJ@186801|Clostridia,3WCM5@538999|Clostridiales incertae sedis	186801|Clostridia	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	-	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
REGS1_k127_2215982_4	1121927.GOHSU_02_01200	1.005e-05	49.0	COG0291@1|root,COG0291@2|Bacteria,2GQZW@201174|Actinobacteria,4GEUI@85026|Gordoniaceae	201174|Actinobacteria	J	Ribosomal protein L35	rpmI	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02916	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35p
REGS1_k127_2215982_1	383372.Rcas_1434	6.107e-55	199.0	COG0290@1|root,COG0290@2|Bacteria,2G6N2@200795|Chloroflexi,375HT@32061|Chloroflexia	32061|Chloroflexia	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	-	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
REGS1_k127_2215982_0	926569.ANT_30990	8.163e-77	263.0	COG1117@1|root,COG1117@2|Bacteria	2|Bacteria	P	ATPase-coupled phosphate ion transmembrane transporter activity	pstB	-	3.6.3.27,3.6.3.55	ko:K02036,ko:K06857	ko02010,map02010	M00186,M00222	R10531	RC00002	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.6.2,3.A.1.6.4,3.A.1.7	-	-	ABC_tran
REGS1_k127_2256496_6	72019.SARC_09696T1	1.446e-40	153.0	COG0590@1|root,KOG1018@2759|Eukaryota,3A5V2@33154|Opisthokonta	33154|Opisthokonta	F	deaminase	-	GO:0003674,GO:0003824,GO:0004131,GO:0005488,GO:0006139,GO:0006206,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009112,GO:0009451,GO:0009987,GO:0016070,GO:0016787,GO:0016810,GO:0016814,GO:0019239,GO:0019858,GO:0034641,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0072527,GO:0090304,GO:1901360,GO:1901564	-	-	-	-	-	-	-	-	-	-	MafB19-deam,dCMP_cyt_deam_1
REGS1_k127_2256496_7	1185876.BN8_00946	6.544e-14	83.0	COG0823@1|root,COG0823@2|Bacteria,4NYXJ@976|Bacteroidetes	976|Bacteroidetes	U	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	PD40
REGS1_k127_2256496_1	477974.Daud_0100	9.899e-108	357.0	COG0413@1|root,COG0413@2|Bacteria,1TPZA@1239|Firmicutes,248RR@186801|Clostridia,260CY@186807|Peptococcaceae	186801|Clostridia	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
REGS1_k127_2256496_3	765420.OSCT_0762	5.717e-72	253.0	COG1893@1|root,COG1893@2|Bacteria,2G9PB@200795|Chloroflexi,3772C@32061|Chloroflexia	32061|Chloroflexia	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
REGS1_k127_2256496_2	1128421.JAGA01000002_gene351	8.655e-100	333.0	COG0414@1|root,COG0414@2|Bacteria,2NP0J@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate	panC	GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_ligase
REGS1_k127_2256496_0	504728.K649_12300	3.249e-110	362.0	COG1521@1|root,COG1521@2|Bacteria,1WI0G@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	F	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis	coaX	-	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Pan_kinase
REGS1_k127_2256496_4	1242864.D187_008621	9.208e-63	225.0	COG4377@1|root,COG4377@2|Bacteria,1QACG@1224|Proteobacteria,43DZN@68525|delta/epsilon subdivisions,2WZAB@28221|Deltaproteobacteria,2Z1PM@29|Myxococcales	28221|Deltaproteobacteria	S	Putative membrane peptidase family (DUF2324)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2324
REGS1_k127_2256496_5	251221.35210810	2.416e-57	211.0	COG5295@1|root,COG5295@2|Bacteria,1GB93@1117|Cyanobacteria	1117|Cyanobacteria	UW	Hep Hag repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_226254_2	383372.Rcas_2343	2.925e-50	188.0	COG0500@1|root,COG2226@2|Bacteria,2GACE@200795|Chloroflexi,37588@32061|Chloroflexia	32061|Chloroflexia	Q	PFAM Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
REGS1_k127_226254_1	324602.Caur_0634	2.085e-64	239.0	COG1807@1|root,COG1807@2|Bacteria,2GBWH@200795|Chloroflexi,3756N@32061|Chloroflexia	32061|Chloroflexia	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
REGS1_k127_226254_0	357808.RoseRS_2840	2.163e-83	290.0	COG0438@1|root,COG0438@2|Bacteria,2G9D7@200795|Chloroflexi,3754H@32061|Chloroflexia	32061|Chloroflexia	M	PFAM glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_2,Glyco_trans_1_4,Glyco_trans_4_4
REGS1_k127_226254_3	1128421.JAGA01000002_gene386	3.674e-12	70.0	COG0297@1|root,COG0297@2|Bacteria	2|Bacteria	G	glycogen (starch) synthase activity	-	-	2.4.1.345	ko:K08256	-	-	R11702	-	ko00000,ko01000,ko01003	-	GT4	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
REGS1_k127_228323_1	1382356.JQMP01000004_gene499	4.421e-85	291.0	COG1063@1|root,COG1063@2|Bacteria,2G7NV@200795|Chloroflexi,27Y3N@189775|Thermomicrobia	189775|Thermomicrobia	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
REGS1_k127_228323_5	130081.XP_005706043.1	4.474e-21	105.0	KOG3178@1|root,KOG3178@2759|Eukaryota	2759|Eukaryota	D	O-methyltransferase activity	ASMTL	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008172,GO:0008757,GO:0009058,GO:0009059,GO:0009308,GO:0009309,GO:0009987,GO:0010467,GO:0010817,GO:0016740,GO:0016741,GO:0017096,GO:0017144,GO:0018130,GO:0019438,GO:0019538,GO:0030186,GO:0030187,GO:0032259,GO:0034641,GO:0034645,GO:0034754,GO:0042401,GO:0042430,GO:0042435,GO:0042445,GO:0042446,GO:0042802,GO:0042803,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046483,GO:0046983,GO:0048519,GO:0050789,GO:0050793,GO:0051093,GO:0051239,GO:0051241,GO:0065007,GO:0065008,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1905939,GO:1905940,GO:2000018,GO:2000019,GO:2000026,GO:2000241,GO:2000242	2.1.1.4	ko:K00543,ko:K13169	ko00380,ko01100,map00380,map01100	M00037	R03130,R04905	RC00003,RC00392	ko00000,ko00001,ko00002,ko01000,ko03041	-	-	-	Dimerisation2,Maf,Methyltransf_2
REGS1_k127_228323_0	926569.ANT_04950	2.129e-184	584.0	COG0183@1|root,COG0183@2|Bacteria,2G5YW@200795|Chloroflexi	200795|Chloroflexi	I	Belongs to the thiolase family	-	-	-	-	-	-	-	-	-	-	-	-	Thiolase_C,Thiolase_N
REGS1_k127_228323_2	1201288.M900_1155	9.783e-79	272.0	COG3396@1|root,COG3396@2|Bacteria,1MVQ7@1224|Proteobacteria,43187@68525|delta/epsilon subdivisions,2WWG4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Phenylacetic acid catabolic protein	-	-	1.14.13.149	ko:K02609	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001,ko01000	-	-	-	PaaA_PaaC
REGS1_k127_228323_4	401053.AciPR4_3666	2.821e-47	181.0	COG2267@1|root,COG2267@2|Bacteria,3Y77N@57723|Acidobacteria	2|Bacteria	I	PFAM Alpha beta hydrolase	pip	-	3.4.11.5	ko:K01259	ko00330,map00330	-	R00135	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Abhydrolase_1
REGS1_k127_228323_3	644966.Tmar_2131	6.684e-76	263.0	COG1024@1|root,COG1024@2|Bacteria,1TQ2V@1239|Firmicutes,24HM8@186801|Clostridia,3WDT7@538999|Clostridiales incertae sedis	186801|Clostridia	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	5.3.3.18	ko:K15866	ko00360,ko01120,map00360,map01120	-	R09837,R09839	RC00004,RC00326,RC02689,RC03003	ko00000,ko00001,ko01000	-	-	-	ECH_1
REGS1_k127_2311545_1	357808.RoseRS_3869	3.779e-55	195.0	COG0451@1|root,COG0451@2|Bacteria,2G7KN@200795|Chloroflexi,375A6@32061|Chloroflexia	32061|Chloroflexia	M	PFAM NAD-dependent epimerase dehydratase	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
REGS1_k127_2311545_0	604354.TSIB_2051	2.612e-117	388.0	COG0399@1|root,arCOG00118@2157|Archaea,2XTRQ@28890|Euryarchaeota,243U2@183968|Thermococci	183968|Thermococci	E	Beta-eliminating lyase	-	-	2.6.1.102	ko:K13010	ko00520,map00520	-	R10460	RC00006,RC00781	ko00000,ko00001,ko01000,ko01005,ko01007	-	-	-	DegT_DnrJ_EryC1
REGS1_k127_2311545_3	326427.Cagg_2232	3.626e-16	84.0	COG2510@1|root,COG2510@2|Bacteria	2|Bacteria	EG	membrane	-	-	-	ko:K08978,ko:K12962	ko01503,map01503	M00721	-	-	ko00000,ko00001,ko00002,ko01005,ko02000	2.A.7.2,2.A.7.22	-	-	EamA
REGS1_k127_2311545_2	326427.Cagg_2232	9.214e-24	105.0	COG2510@1|root,COG2510@2|Bacteria	2|Bacteria	EG	membrane	-	-	-	ko:K08978,ko:K12962	ko01503,map01503	M00721	-	-	ko00000,ko00001,ko00002,ko01005,ko02000	2.A.7.2,2.A.7.22	-	-	EamA
REGS1_k127_2311545_4	479434.Sthe_0212	8.044e-16	78.0	2DRHT@1|root,33BTG@2|Bacteria,2G7I1@200795|Chloroflexi,27YR7@189775|Thermomicrobia	189775|Thermomicrobia	S	TIGRFAM lysine biosynthesis protein LysW	-	-	-	ko:K05826	-	M00031,M00763	-	-	ko00000,ko00001,ko00002	-	-	-	-
REGS1_k127_2314721_1	383372.Rcas_4275	1.761e-40	158.0	COG2812@1|root,COG2812@2|Bacteria,2G6K3@200795|Chloroflexi,37807@32061|Chloroflexia	32061|Chloroflexia	L	TIGRFAM DNA polymerase III, delta prime subunit	-	-	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2
REGS1_k127_2314721_0	1541065.JRFE01000024_gene1028	4.025e-109	362.0	COG1304@1|root,COG1304@2|Bacteria,1G2KC@1117|Cyanobacteria,3VJ5M@52604|Pleurocapsales	1117|Cyanobacteria	C	Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)	fni	-	5.3.3.2	ko:K01823	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00095,M00096,M00364,M00365,M00366,M00367	R01123	RC00455	ko00000,ko00001,ko00002,ko01000	-	-	-	FMN_dh
REGS1_k127_2314721_2	1128421.JAGA01000002_gene1527	1.892e-28	133.0	COG1287@1|root,COG1287@2|Bacteria	2|Bacteria	S	oligosaccharyl transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,PMT_2
REGS1_k127_2332687_0	398767.Glov_2400	3.884e-116	387.0	COG1775@1|root,COG1775@2|Bacteria,1NKED@1224|Proteobacteria,430HE@68525|delta/epsilon subdivisions,2WVZI@28221|Deltaproteobacteria,43V4N@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	2-hydroxyglutaryl-CoA dehydratase, D-component	-	-	1.3.7.8	ko:K04113	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R02451	RC00002,RC01839	ko00000,ko00001,ko00002,ko01000	-	-	-	HGD-D
REGS1_k127_2332687_1	398767.Glov_2399	2.246e-94	317.0	COG1924@1|root,COG1924@2|Bacteria,1R6HU@1224|Proteobacteria,42RWX@68525|delta/epsilon subdivisions,2WNC9@28221|Deltaproteobacteria,43V8M@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	BadF/BadG/BcrA/BcrD ATPase family	yjiL	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG
REGS1_k127_2332687_2	398767.Glov_2399	1.776e-59	215.0	COG1924@1|root,COG1924@2|Bacteria,1R6HU@1224|Proteobacteria,42RWX@68525|delta/epsilon subdivisions,2WNC9@28221|Deltaproteobacteria,43V8M@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	BadF/BadG/BcrA/BcrD ATPase family	yjiL	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG
REGS1_k127_234391_1	926569.ANT_09980	9.787e-209	663.0	COG0085@1|root,COG0085@2|Bacteria,2G5VH@200795|Chloroflexi	200795|Chloroflexi	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
REGS1_k127_234391_2	1128421.JAGA01000002_gene690	1.427e-63	222.0	COG0048@1|root,COG0048@2|Bacteria,2NPA7@2323|unclassified Bacteria	2|Bacteria	J	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit	rpsL	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
REGS1_k127_234391_3	525904.Tter_0711	3.005e-56	203.0	COG0049@1|root,COG0049@2|Bacteria,2NP7H@2323|unclassified Bacteria	2|Bacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA	rpsG	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0016020,GO:0016043,GO:0017148,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
REGS1_k127_234391_0	525904.Tter_0712	1.485e-270	845.0	COG0480@1|root,COG0480@2|Bacteria,2NNSV@2323|unclassified Bacteria	2|Bacteria	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0019538,GO:0030312,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
REGS1_k127_2352431_4	449447.MAE_20920	1.091e-63	222.0	COG3335@1|root,COG3335@2|Bacteria,1G5W5@1117|Cyanobacteria	1117|Cyanobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3
REGS1_k127_2352431_0	1128421.JAGA01000002_gene1253	1.048e-150	490.0	COG0464@1|root,COG0464@2|Bacteria	2|Bacteria	O	ATPase activity	-	-	-	-	-	-	-	-	-	-	-	-	AAA
REGS1_k127_2352431_7	573065.Astex_1574	1.994e-24	116.0	28MCN@1|root,2ZAQR@2|Bacteria,1N00X@1224|Proteobacteria,2UG9Y@28211|Alphaproteobacteria,2KJ78@204458|Caulobacterales	204458|Caulobacterales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_2352431_8	1480694.DC28_01030	5.85e-24	106.0	COG0724@1|root,COG0724@2|Bacteria	2|Bacteria	K	RNA recognition motif	rbp	-	-	-	-	-	-	-	-	-	-	-	RRM_1
REGS1_k127_2352431_1	926550.CLDAP_05980	7.034e-94	320.0	COG3842@1|root,COG3842@2|Bacteria,2G6S3@200795|Chloroflexi	200795|Chloroflexi	P	Belongs to the ABC transporter superfamily	-	-	3.6.3.29	ko:K02017	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.8	-	-	ABC_tran,TOBE_2
REGS1_k127_2352431_2	694440.JOMF01000006_gene451	2.557e-65	233.0	COG0555@1|root,arCOG00164@2157|Archaea,2XVJ4@28890|Euryarchaeota,2N9S1@224756|Methanomicrobia	224756|Methanomicrobia	P	PFAM binding-protein-dependent transport systems inner membrane component	modB	-	-	ko:K02018	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	BPD_transp_1
REGS1_k127_2352431_3	765420.OSCT_1869	1.284e-64	231.0	COG0725@1|root,COG0725@2|Bacteria,2G6J6@200795|Chloroflexi,376S8@32061|Chloroflexia	32061|Chloroflexia	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02020	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	SBP_bac_11
REGS1_k127_2352431_6	383372.Rcas_2179	7.701e-31	128.0	COG1695@1|root,COG1695@2|Bacteria,2G7I0@200795|Chloroflexi,377DV@32061|Chloroflexia	32061|Chloroflexia	K	PFAM transcriptional regulator PadR family protein	-	-	-	-	-	-	-	-	-	-	-	-	PadR,Vir_act_alpha_C
REGS1_k127_2352431_5	485913.Krac_7095	8.862e-57	213.0	COG5433@1|root,COG5433@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_assoc
REGS1_k127_2380110_0	479434.Sthe_3518	4.414e-135	444.0	COG0215@1|root,COG0215@2|Bacteria,2G5Z0@200795|Chloroflexi,27XXR@189775|Thermomicrobia	189775|Thermomicrobia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	-	-	6.3.1.13	ko:K15526	-	-	-	-	ko00000,ko01000	-	-	-	DALR_2,tRNA-synt_1e,tRNA-synt_1g
REGS1_k127_2380110_2	1128421.JAGA01000004_gene2627	2.525e-103	347.0	COG0836@1|root,COG0836@2|Bacteria,2NP3C@2323|unclassified Bacteria	2|Bacteria	M	Mannose-6-phosphate isomerase	manC	-	2.7.7.13,5.3.1.8	ko:K00971,ko:K16011	ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025	M00114,M00361,M00362	R00885,R01819	RC00002,RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
REGS1_k127_2380110_11	335541.Swol_1062	3.801e-20	106.0	COG3023@1|root,COG3023@2|Bacteria,1V7IR@1239|Firmicutes,24QVZ@186801|Clostridia	186801|Clostridia	V	Negative regulator of beta-lactamase expression	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_2
REGS1_k127_2380110_10	309801.trd_1030	3.255e-27	125.0	COG0823@1|root,COG0823@2|Bacteria,2G78A@200795|Chloroflexi,27XKD@189775|Thermomicrobia	189775|Thermomicrobia	U	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_2380110_14	1382306.JNIM01000001_gene3784	0.0002928	52.0	COG1316@1|root,COG1316@2|Bacteria,2G6PZ@200795|Chloroflexi	200795|Chloroflexi	K	TIGRFAM cell envelope-related function transcriptional attenuator, LytR CpsA family	-	-	-	-	-	-	-	-	-	-	-	-	LytR_C,LytR_cpsA_psr
REGS1_k127_2380110_3	485913.Krac_8642	3.673e-97	330.0	COG0206@1|root,COG0206@2|Bacteria,2G5V2@200795|Chloroflexi	200795|Chloroflexi	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
REGS1_k127_2380110_6	1329516.JPST01000014_gene449	4.303e-44	184.0	COG2247@1|root,COG2247@2|Bacteria	2|Bacteria	M	cell wall organization	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,CW_binding_2,Peptidase_S8,SH3_3,SLT,SpoIID,WG_beta_rep
REGS1_k127_2380110_13	1304880.JAGB01000001_gene667	8.378e-13	77.0	COG1193@1|root,COG1193@2|Bacteria,1UHZ5@1239|Firmicutes,25E7T@186801|Clostridia	186801|Clostridia	L	negative regulation of DNA recombination	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_2380110_4	926569.ANT_16850	4.332e-58	228.0	29DKV@1|root,300IP@2|Bacteria,2G8H2@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_2380110_8	215803.DB30_2713	1.622e-33	152.0	COG0457@1|root,COG0457@2|Bacteria,1PEH7@1224|Proteobacteria,42TVC@68525|delta/epsilon subdivisions,2WSCX@28221|Deltaproteobacteria,2YZCB@29|Myxococcales	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_11,TPR_14,TPR_16,TPR_2,TPR_4,TPR_6,TPR_8
REGS1_k127_2380110_7	1382359.JIAL01000001_gene84	7.876e-35	156.0	COG0457@1|root,COG0457@2|Bacteria,3Y4S2@57723|Acidobacteria,2JM74@204432|Acidobacteriia	204432|Acidobacteriia	NU	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_11,TPR_16,TPR_6,TPR_8
REGS1_k127_2380110_12	383372.Rcas_0214	3.115e-14	77.0	2ERVP@1|root,33JEV@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_2380110_1	350688.Clos_1079	1.485e-115	384.0	COG2204@1|root,COG2204@2|Bacteria,1VSKG@1239|Firmicutes,24ZP4@186801|Clostridia,36EVK@31979|Clostridiaceae	186801|Clostridia	T	Two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
REGS1_k127_2380110_5	269799.Gmet_2562	2.017e-46	193.0	COG3852@1|root,COG3852@2|Bacteria,1NTTH@1224|Proteobacteria,42MC9@68525|delta/epsilon subdivisions,2WIYS@28221|Deltaproteobacteria,43T97@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Nitrogen fixation master sensor histidine kinase, PAS domain-containing	gnfL	-	2.7.13.3	ko:K02668,ko:K07708,ko:K07709	ko02020,map02020	M00497,M00499,M00501	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_8
REGS1_k127_2380110_9	485913.Krac_10920	1.949e-33	133.0	COG1508@1|root,COG1508@2|Bacteria,2G5VM@200795|Chloroflexi	200795|Chloroflexi	K	TIGRFAM RNA polymerase sigma-54 factor, RpoN	-	-	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
REGS1_k127_2408704_0	867845.KI911784_gene450	7.387e-49	185.0	COG1413@1|root,COG1413@2|Bacteria,2G6MW@200795|Chloroflexi,375QB@32061|Chloroflexia	32061|Chloroflexia	C	PBS lyase HEAT domain protein repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
REGS1_k127_2408704_1	926569.ANT_25740	3.101e-32	145.0	COG0863@1|root,COG0863@2|Bacteria	2|Bacteria	L	N-4 methylation of cytosine	-	-	2.1.1.113	ko:K00590	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	-
REGS1_k127_2415164_9	65071.PYU1_T014044	7.266e-81	273.0	COG0458@1|root,KOG0370@2759|Eukaryota,1MADF@121069|Pythiales	121069|Pythiales	EF	Aspartate carbamoyltransferase. Source PGD	-	-	-	-	-	-	-	-	-	-	-	-	OTCace,OTCace_N
REGS1_k127_2415164_2	5693.XP_811679.1	3.951e-156	505.0	COG0461@1|root,KOG1377@2759|Eukaryota,3XSWC@5653|Kinetoplastida	5653|Kinetoplastida	F	Orotidine-5-phosphate decarboxylase orotate phosphoribosyltransferase	-	-	2.4.2.10,4.1.1.23	ko:K01591,ko:K13421	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00051	R00965,R01870,R08231	RC00063,RC00409,RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase,Pribosyltran
REGS1_k127_2415164_7	1122221.JHVI01000018_gene1505	5.061e-95	322.0	COG0167@1|root,COG0167@2|Bacteria,1WI2W@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	F	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor	pyrD	-	1.3.5.2	ko:K00254	ko00240,ko01100,map00240,map01100	M00051	R01868	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
REGS1_k127_2415164_5	926550.CLDAP_28240	1.016e-104	343.0	COG0235@1|root,COG0235@2|Bacteria,2G63H@200795|Chloroflexi	200795|Chloroflexi	G	Class II Aldolase and Adducin N-terminal domain	-	-	5.1.3.4	ko:K03077	ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120	M00550	R05850	RC01479	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase_II
REGS1_k127_2415164_0	926569.ANT_13670	1.699e-263	821.0	COG1069@1|root,COG1069@2|Bacteria,2G8AT@200795|Chloroflexi	200795|Chloroflexi	C	FGGY family of carbohydrate kinases, N-terminal domain	araB	-	2.7.1.16	ko:K00853	ko00040,ko01100,map00040,map01100	-	R01526,R02439	RC00002,RC00538	ko00000,ko00001,ko01000	-	-	-	FGGY_C,FGGY_N
REGS1_k127_2415164_6	28444.JODQ01000017_gene6503	6.879e-99	333.0	COG1063@1|root,COG1063@2|Bacteria,2GKC7@201174|Actinobacteria,4EPJ4@85012|Streptosporangiales	201174|Actinobacteria	C	Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.14,1.1.1.264,1.1.1.303,1.1.1.4	ko:K00004,ko:K00008,ko:K00098	ko00040,ko00051,ko00650,ko01100,map00040,map00051,map00650,map01100	M00014	R00875,R01896,R02855,R02946,R05684,R10504	RC00085,RC00089,RC00102,RC00205,RC00525	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
REGS1_k127_2415164_3	926550.CLDAP_28230	4.24e-134	437.0	COG0006@1|root,COG0006@2|Bacteria,2G6N9@200795|Chloroflexi	200795|Chloroflexi	E	Metallopeptidase family M24	-	-	-	ko:K18829	-	-	-	-	ko00000,ko02048	-	-	-	Peptidase_M24
REGS1_k127_2415164_8	1499967.BAYZ01000073_gene2029	3.609e-84	283.0	COG2755@1|root,COG2755@2|Bacteria	2|Bacteria	E	lipolytic protein G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
REGS1_k127_2415164_1	926569.ANT_26630	1.345e-156	499.0	COG0667@1|root,COG0667@2|Bacteria,2G5VT@200795|Chloroflexi	200795|Chloroflexi	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
REGS1_k127_2415164_4	1128421.JAGA01000001_gene2416	1.864e-130	421.0	COG2160@1|root,COG2160@2|Bacteria	2|Bacteria	G	L-arabinose isomerase activity	araA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008733,GO:0009056,GO:0009058,GO:0009987,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019323,GO:0019566,GO:0019568,GO:0019569,GO:0019572,GO:0019637,GO:0044237,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046373,GO:0051167,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901159,GO:1901575,GO:1901576	5.3.1.4	ko:K01804	ko00040,ko01100,map00040,map01100	-	R01761	RC00516	ko00000,ko00001,ko01000	-	-	iAPECO1_1312.APECO1_1922,iB21_1397.B21_00063,iBWG_1329.BWG_0058,iE2348C_1286.E2348C_0063,iECBD_1354.ECBD_3555,iECD_1391.ECD_00064,iECED1_1282.ECED1_0061,iECIAI1_1343.ECIAI1_0062,iECNA114_1301.ECNA114_0050,iECO103_1326.ECO103_0063,iECO26_1355.ECO26_0064,iECOK1_1307.ECOK1_0061,iECP_1309.ECP_0063,iECS88_1305.ECS88_0065,iECSE_1348.ECSE_0062,iECW_1372.ECW_m0060,iEKO11_1354.EKO11_3852,iEcE24377_1341.EcE24377A_0064,iEcHS_1320.EcHS_A0066,iEcSMS35_1347.EcSMS35_0064,iEcolC_1368.EcolC_3595,iLF82_1304.LF82_0105,iLJ478.TM0276,iNRG857_1313.NRG857_00320,iSBO_1134.SBO_0049,iSSON_1240.SSON_0068,iUMN146_1321.UM146_23095,iUTI89_1310.UTI89_C0067,iWFL_1372.ECW_m0060	Arabinose_Iso_C,Arabinose_Isome
REGS1_k127_2435180_1	1379698.RBG1_1C00001G0703	1.08e-47	177.0	COG0124@1|root,COG0124@2|Bacteria,2NNZ7@2323|unclassified Bacteria	2|Bacteria	J	Histidyl-tRNA synthetase	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
REGS1_k127_2435180_2	926550.CLDAP_01890	2.794e-31	135.0	COG0834@1|root,COG0834@2|Bacteria,2G8WT@200795|Chloroflexi	200795|Chloroflexi	ET	extracellular solute-binding protein, family 3	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
REGS1_k127_2435180_0	926550.CLDAP_01880	1.653e-135	441.0	COG3664@1|root,COG3664@2|Bacteria,2G82D@200795|Chloroflexi	200795|Chloroflexi	G	PFAM glycoside hydrolase family 39	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_2440160_1	497965.Cyan7822_0257	4.252e-37	143.0	COG1506@1|root,COG1506@2|Bacteria,1G200@1117|Cyanobacteria,3KFR1@43988|Cyanothece	1117|Cyanobacteria	E	PFAM peptidase S9 prolyl oligopeptidase active site domain protein	dap2	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
REGS1_k127_2440160_0	383372.Rcas_0339	9.473e-224	706.0	COG1217@1|root,COG1217@2|Bacteria,2G5NQ@200795|Chloroflexi,3757V@32061|Chloroflexia	32061|Chloroflexia	T	elongation factor Tu domain 2 protein	-	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
REGS1_k127_2444915_0	485913.Krac_5846	2.74e-139	447.0	COG0076@1|root,COG0076@2|Bacteria,2G76V@200795|Chloroflexi	200795|Chloroflexi	H	COGs COG0076 Glutamate decarboxylase and related PLP-dependent protein	-	-	4.1.2.27	ko:K01634	ko00600,ko01100,ko04071,map00600,map01100,map04071	M00100	R02464,R06516	RC00264,RC00721,RC01266	ko00000,ko00001,ko00002,ko01000	-	-	-	Pyridoxal_deC
REGS1_k127_2451395_2	760192.Halhy_1193	2.542e-75	263.0	COG2010@1|root,COG2010@2|Bacteria,4NHQV@976|Bacteroidetes,1IXTS@117747|Sphingobacteriia	976|Bacteroidetes	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
REGS1_k127_2451395_0	357808.RoseRS_2057	1.88e-105	359.0	COG2770@1|root,COG5002@1|root,COG2770@2|Bacteria,COG5002@2|Bacteria,2G68T@200795|Chloroflexi,375B4@32061|Chloroflexia	32061|Chloroflexia	T	histidine kinase HAMP region domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
REGS1_k127_2451395_3	357808.RoseRS_4428	4.657e-37	143.0	COG0399@1|root,COG0399@2|Bacteria,2G7J4@200795|Chloroflexi	200795|Chloroflexi	E	Belongs to the DegT DnrJ EryC1 family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
REGS1_k127_2451395_1	926569.ANT_28720	2.116e-92	308.0	COG0745@1|root,COG0745@2|Bacteria,2G5TG@200795|Chloroflexi	200795|Chloroflexi	K	Two component transcriptional regulator, winged helix family	-	-	-	ko:K07669	ko02020,map02020	M00460	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
REGS1_k127_2456191_9	398512.JQKC01000013_gene1407	3.728e-09	63.0	COG5513@1|root,COG5513@2|Bacteria,1VGF2@1239|Firmicutes,24UJK@186801|Clostridia,3WN94@541000|Ruminococcaceae	186801|Clostridia	M	Chagasin family peptidase inhibitor I42	-	-	-	ko:K14475	ko05143,map05143	-	-	-	ko00000,ko00001	-	-	-	Dockerin_1,Inhibitor_I42
REGS1_k127_2456191_0	671143.DAMO_0652	2.132e-218	684.0	COG0183@1|root,COG0183@2|Bacteria,2NP9T@2323|unclassified Bacteria	2|Bacteria	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
REGS1_k127_2456191_6	671143.DAMO_0654	2.395e-53	193.0	COG1545@1|root,COG1545@2|Bacteria	2|Bacteria	I	DUF35 OB-fold domain, acyl-CoA-associated	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
REGS1_k127_2456191_4	1382306.JNIM01000001_gene2595	6.022e-102	342.0	COG0604@1|root,COG0604@2|Bacteria,2G6DS@200795|Chloroflexi	200795|Chloroflexi	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
REGS1_k127_2456191_1	1081644.IMCC13023_12700	7.118e-153	497.0	COG0017@1|root,COG0017@2|Bacteria,2I2KQ@201174|Actinobacteria,4FKWR@85023|Microbacteriaceae	201174|Actinobacteria	J	Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp)	aspS	-	6.1.1.12,6.1.1.23	ko:K01876,ko:K09759	ko00970,map00970	M00359,M00360	R03647,R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	tRNA-synt_2,tRNA_anti-codon
REGS1_k127_2456191_5	1128421.JAGA01000002_gene1813	2.995e-88	303.0	COG3407@1|root,COG3407@2|Bacteria,2NQTF@2323|unclassified Bacteria	2|Bacteria	I	GHMP kinases N terminal domain	mvaD	-	4.1.1.33	ko:K01597	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00095	R01121	RC00453	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
REGS1_k127_2456191_7	309801.trd_1057	1.184e-50	200.0	COG0750@1|root,COG0750@2|Bacteria,2G6HV@200795|Chloroflexi,27XS5@189775|Thermomicrobia	189775|Thermomicrobia	M	Domain present in PSD-95, Dlg, and ZO-1/2.	-	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_M50
REGS1_k127_2456191_3	485913.Krac_3074	2.753e-129	424.0	COG0665@1|root,COG0665@2|Bacteria,2G6XM@200795|Chloroflexi	200795|Chloroflexi	E	FAD dependent oxidoreductase	-	-	1.5.3.1	ko:K00301	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO
REGS1_k127_2456191_2	1382306.JNIM01000001_gene2737	3.294e-141	464.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3,Sugar_tr
REGS1_k127_2456191_10	635013.TherJR_1117	0.0002086	51.0	COG3005@1|root,COG3005@2|Bacteria,1VTRU@1239|Firmicutes,2500S@186801|Clostridia,264IC@186807|Peptococcaceae	2|Bacteria	C	denitrification pathway	-	-	-	ko:K02569,ko:K15876	ko00910,ko01120,map00910,map01120	M00530	R05712	RC00176	ko00000,ko00001,ko00002	-	-	-	Cytochrom_NNT
REGS1_k127_2456191_8	1123242.JH636435_gene2319	4.974e-41	153.0	COG0842@1|root,COG0842@2|Bacteria	2|Bacteria	V	Transport permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
REGS1_k127_2467513_1	526227.Mesil_1308	3.941e-72	251.0	COG1914@1|root,COG1914@2|Bacteria,1WM66@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	Natural resistance-associated macrophage protein	-	-	-	-	-	-	-	-	-	-	-	-	Nramp
REGS1_k127_2467513_0	1121377.KB906405_gene101	4.253e-126	412.0	COG0208@1|root,COG0208@2|Bacteria,1WM54@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	F	fatty acid desaturase	staD	-	1.14.19.11,1.14.19.2,1.14.19.26	ko:K03921	ko00061,ko01040,ko01212,map00061,map01040,map01212	-	R03370,R08161,R11108,R11109	RC00917	ko00000,ko00001,ko01000,ko01004	-	-	-	FA_desaturase_2
REGS1_k127_2467513_3	1214101.BN159_8012	1.43e-56	209.0	COG2230@1|root,COG2230@2|Bacteria	2|Bacteria	M	cyclopropane-fatty-acyl-phospholipid synthase	-	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS,Methyltransf_25
REGS1_k127_2467513_2	439235.Dalk_1526	9.642e-59	228.0	COG0457@1|root,COG2114@1|root,COG3899@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,42NXT@68525|delta/epsilon subdivisions,2WIZ3@28221|Deltaproteobacteria,2MKIU@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,DZR,Guanylate_cyc,Pkinase,TPR_12
REGS1_k127_2471763_2	1120966.AUBU01000014_gene597	9.016e-79	272.0	COG1235@1|root,COG1235@2|Bacteria,4NM16@976|Bacteroidetes,47U32@768503|Cytophagia	976|Bacteroidetes	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
REGS1_k127_2471763_4	1239962.C943_02138	3.725e-39	149.0	2BWYK@1|root,32R5D@2|Bacteria,4NS4D@976|Bacteroidetes,47UWC@768503|Cytophagia	976|Bacteroidetes	T	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	PAS_4,PAS_8
REGS1_k127_2471763_3	640511.BC1002_7112	3.527e-76	268.0	COG0644@1|root,COG0644@2|Bacteria,1PGHR@1224|Proteobacteria,2VT2Q@28216|Betaproteobacteria,1KAQP@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Lycopene cyclase protein	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_2471763_1	41431.PCC8801_2625	8.041e-106	362.0	28IH4@1|root,2Z8IE@2|Bacteria,1G5H6@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_2471763_0	357808.RoseRS_3819	1.018e-109	366.0	COG0153@1|root,COG0153@2|Bacteria,2G6CE@200795|Chloroflexi,375CJ@32061|Chloroflexia	32061|Chloroflexia	F	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)	galK	-	2.7.1.6	ko:K00849	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00554,M00632	R01092	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg
REGS1_k127_2471763_5	1410676.JNKL01000038_gene1487	5.432e-11	64.0	COG1085@1|root,COG1085@2|Bacteria,1MU3E@1224|Proteobacteria,1RMDK@1236|Gammaproteobacteria,1Y5EM@135624|Aeromonadales	135624|Aeromonadales	C	Galactose-1-phosphate uridyl transferase, C-terminal domain	galT	-	2.7.7.12	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	M00362,M00554,M00632	R00955	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	GalP_UDP_tr_C,GalP_UDP_transf
REGS1_k127_2482246_0	926569.ANT_14380	8.215e-158	510.0	COG0624@1|root,COG0624@2|Bacteria,2G5KY@200795|Chloroflexi	200795|Chloroflexi	E	peptidase dimerisation domain protein	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
REGS1_k127_2482246_1	1173024.KI912149_gene6518	4.353e-09	59.0	COG0814@1|root,COG0814@2|Bacteria,1G4RP@1117|Cyanobacteria	1117|Cyanobacteria	E	amino acid	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_2484018_0	426355.Mrad2831_0213	9.65e-160	534.0	COG0642@1|root,COG2199@1|root,COG2205@2|Bacteria,COG3706@2|Bacteria,1NRP8@1224|Proteobacteria,2VDSR@28211|Alphaproteobacteria,1JRF8@119045|Methylobacteriaceae	28211|Alphaproteobacteria	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS_3,PAS_7,Response_reg
REGS1_k127_2484149_0	521045.Kole_0624	3.478e-81	279.0	COG1028@1|root,COG1028@2|Bacteria	521045.Kole_0624|-	IQ	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_2484149_7	446470.Snas_5852	9.062e-24	110.0	2EIQA@1|root,33CFR@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_2484149_4	768710.DesyoDRAFT_1329	8.139e-54	211.0	COG0596@1|root,COG0596@2|Bacteria,1V0M4@1239|Firmicutes,24AEI@186801|Clostridia,262HK@186807|Peptococcaceae	186801|Clostridia	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
REGS1_k127_2484149_6	1150398.JIBJ01000012_gene2070	4.827e-41	171.0	COG3832@1|root,COG3832@2|Bacteria,2GY9A@201174|Actinobacteria	201174|Actinobacteria	E	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_2484149_2	485913.Krac_12560	6.791e-61	218.0	COG0745@1|root,COG0745@2|Bacteria,2G5ND@200795|Chloroflexi	200795|Chloroflexi	K	Two component transcriptional regulator, winged helix family	-	-	-	ko:K07667,ko:K07668	ko02020,ko02024,map02020,map02024	M00454,M00459	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
REGS1_k127_2484149_5	1122222.AXWR01000019_gene2702	4.616e-43	163.0	COG0517@1|root,COG0517@2|Bacteria,1WMQJ@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	ko:K04767	-	-	-	-	ko00000	-	-	-	CBS
REGS1_k127_2484149_3	485917.Phep_3370	9.755e-55	213.0	COG2202@1|root,COG4191@1|root,COG5002@1|root,COG2202@2|Bacteria,COG4191@2|Bacteria,COG5002@2|Bacteria,4P35V@976|Bacteroidetes,1IS0N@117747|Sphingobacteriia	976|Bacteroidetes	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_9
REGS1_k127_2484149_1	1123511.KB905843_gene1003	4.489e-68	245.0	COG0348@1|root,COG0348@2|Bacteria,1U9JQ@1239|Firmicutes	1239|Firmicutes	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_5
REGS1_k127_2492031_1	1462527.CCDM010000001_gene2083	1.255e-70	250.0	COG0395@1|root,COG0395@2|Bacteria,1TRCP@1239|Firmicutes,4HBKE@91061|Bacilli,23KMC@182709|Oceanobacillus	91061|Bacilli	G	Binding-protein-dependent transport system inner membrane component	malF	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
REGS1_k127_2492031_2	1122918.KB907245_gene5306	3.815e-65	236.0	COG1175@1|root,COG1175@2|Bacteria,1TREE@1239|Firmicutes	2|Bacteria	P	ABC transporter (Permease	-	-	-	ko:K02025,ko:K15771	ko02010,map02010	M00207,M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.16,3.A.1.1.2	-	-	BPD_transp_1
REGS1_k127_2492031_3	383372.Rcas_3538	2.434e-47	186.0	COG0628@1|root,COG0628@2|Bacteria	2|Bacteria	D	permease	-	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
REGS1_k127_2492031_5	1056512.D515_00682	1.241e-08	65.0	COG0454@1|root,COG0456@2|Bacteria,1N4U8@1224|Proteobacteria	1224|Proteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
REGS1_k127_2492031_0	768671.ThimaDRAFT_1489	3.015e-104	347.0	COG0463@1|root,COG0463@2|Bacteria,1MWE5@1224|Proteobacteria,1RPCE@1236|Gammaproteobacteria,1WXRF@135613|Chromatiales	135613|Chromatiales	M	PFAM Glycosyl transferase family 2	-	-	2.4.2.53	ko:K10012,ko:K20534	ko00520,ko01503,map00520,map01503	M00721,M00761	R07661	RC00005,RC02954	ko00000,ko00001,ko00002,ko01000,ko01005,ko02000	4.D.2.1.8,4.D.2.1.9	GT2	-	Glycos_transf_2
REGS1_k127_2492031_4	926550.CLDAP_32470	8.38e-18	98.0	COG1807@1|root,COG1807@2|Bacteria,2G8DG@200795|Chloroflexi	200795|Chloroflexi	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
REGS1_k127_252652_4	1462526.BN990_03318	0.0002405	44.0	COG0624@1|root,COG0624@2|Bacteria,1TQ0P@1239|Firmicutes,4HAE4@91061|Bacilli,4C68P@84406|Virgibacillus	91061|Bacilli	E	Peptidase family M28	-	-	3.5.1.6,3.5.1.87	ko:K06016	ko00240,ko01100,map00240,map01100	M00046	R00905,R04666	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
REGS1_k127_252652_3	1128421.JAGA01000002_gene283	4.016e-32	129.0	COG0629@1|root,COG0629@2|Bacteria,2NPUB@2323|unclassified Bacteria	2|Bacteria	L	Single-strand binding protein family	ssb	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
REGS1_k127_252652_0	215803.DB30_7188	1.342e-72	255.0	COG0514@1|root,COG0514@2|Bacteria,1MVGG@1224|Proteobacteria,42MV3@68525|delta/epsilon subdivisions,2WJZB@28221|Deltaproteobacteria,2YX5W@29|Myxococcales	28221|Deltaproteobacteria	L	DNA helicase	-	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,HRDC,Helicase_C,RQC,RecQ_Zn_bind
REGS1_k127_252652_2	485916.Dtox_0011	2.205e-50	203.0	COG0514@1|root,COG0514@2|Bacteria,1TPN5@1239|Firmicutes,247ZA@186801|Clostridia,260VD@186807|Peptococcaceae	186801|Clostridia	L	TIGRFAM ATP-dependent DNA helicase, RecQ	recQ	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,HRDC,HTH_40,Helicase_C,RQC,RecQ_Zn_bind
REGS1_k127_252652_1	56780.SYN_02797	1.124e-56	209.0	COG0758@1|root,COG4277@1|root,COG0758@2|Bacteria,COG4277@2|Bacteria,1MVF6@1224|Proteobacteria,42N10@68525|delta/epsilon subdivisions,2WJI9@28221|Deltaproteobacteria,2MQD6@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	TIGRFAM DNA protecting protein DprA	dprA	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
REGS1_k127_2557594_0	1382306.JNIM01000001_gene426	2.403e-209	664.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2G5W2@200795|Chloroflexi	200795|Chloroflexi	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
REGS1_k127_2557594_1	552811.Dehly_0772	1.936e-166	535.0	COG0423@1|root,COG0423@2|Bacteria,2G62M@200795|Chloroflexi,34D2R@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Catalyzes the attachment of glycine to tRNA(Gly)	glyS	-	6.1.1.14	ko:K01880	ko00970,map00970	M00359,M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	HGTP_anticodon,tRNA-synt_2b
REGS1_k127_2557594_5	1128421.JAGA01000002_gene486	9.464e-67	236.0	COG1381@1|root,COG1381@2|Bacteria,2NPV3@2323|unclassified Bacteria	2|Bacteria	L	Involved in DNA repair and RecF pathway recombination	recO	GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0033554,GO:0034641,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
REGS1_k127_2557594_7	526227.Mesil_0390	3.095e-50	180.0	COG1694@1|root,COG1694@2|Bacteria,1WK7E@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	PFAM MazG nucleotide pyrophosphohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	MazG
REGS1_k127_2557594_11	1123376.AUIU01000016_gene233	7.446e-17	96.0	COG2204@1|root,COG2204@2|Bacteria,3J0ZU@40117|Nitrospirae	40117|Nitrospirae	T	Bacterial regulatory protein, Fis family	-	-	-	ko:K07715	ko02020,ko02024,map02020,map02024	M00502	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
REGS1_k127_2557594_6	1121382.JQKG01000036_gene3899	4.292e-61	239.0	COG4585@1|root,COG4585@2|Bacteria,1WIV0@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,GAF_3,HATPase_c,HisKA_3
REGS1_k127_2557594_3	926550.CLDAP_24880	7.484e-147	473.0	COG0468@1|root,COG0468@2|Bacteria,2G5WE@200795|Chloroflexi	200795|Chloroflexi	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
REGS1_k127_2557594_8	525904.Tter_0073	1.239e-39	156.0	COG2137@1|root,COG2137@2|Bacteria,2NPVT@2323|unclassified Bacteria	2|Bacteria	S	Modulates RecA activity	recX	GO:0003674,GO:0005488,GO:0005515,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0019899,GO:0031668,GO:0033554,GO:0043086,GO:0044092,GO:0050790,GO:0050896,GO:0051716,GO:0065007,GO:0065009,GO:0071496	2.4.1.337	ko:K03565,ko:K19002	ko00561,ko01100,map00561,map01100	-	R10850	RC00005,RC00059	ko00000,ko00001,ko01000,ko01003,ko03400	-	GT4	-	RecX
REGS1_k127_2557594_2	926550.CLDAP_00030	9.787e-161	521.0	COG1418@1|root,COG4372@1|root,COG1418@2|Bacteria,COG4372@2|Bacteria,2G620@200795|Chloroflexi	200795|Chloroflexi	S	Endoribonuclease that initiates mRNA decay	rny	-	-	ko:K18682	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DUF3552,HD,KH_1
REGS1_k127_2557594_10	926569.ANT_28350	2.474e-23	104.0	COG2359@1|root,COG2359@2|Bacteria,2G77N@200795|Chloroflexi	200795|Chloroflexi	S	PFAM Stage V sporulation protein S	-	-	-	ko:K06416	-	-	-	-	ko00000	-	-	-	SpoVS
REGS1_k127_2557594_4	485913.Krac_12477	1.739e-73	258.0	COG0613@1|root,COG0613@2|Bacteria,2G6H4@200795|Chloroflexi	200795|Chloroflexi	S	SMART phosphoesterase PHP domain protein	-	-	3.1.3.97	ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	PHP
REGS1_k127_2557594_9	1382306.JNIM01000001_gene1173	6.604e-37	146.0	COG2812@1|root,COG2812@2|Bacteria,2G6K3@200795|Chloroflexi	200795|Chloroflexi	L	DNA polymerase III, delta prime subunit	holB	-	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNApol3-delta_C
REGS1_k127_2575235_4	926550.CLDAP_03230	2.465e-25	121.0	COG5617@1|root,COG5617@2|Bacteria	2|Bacteria	M	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	PTPS_related,YfhO
REGS1_k127_2575235_1	697281.Mahau_1280	7.38e-156	521.0	COG3387@1|root,COG3387@2|Bacteria,1TSFD@1239|Firmicutes,24EW4@186801|Clostridia,42F5M@68295|Thermoanaerobacterales	186801|Clostridia	G	glycoside hydrolase 15-related	-	-	3.2.1.3	ko:K01178	ko00500,ko01100,map00500,map01100	-	R01790,R01791,R06199	-	ko00000,ko00001,ko01000	-	GH15	-	Glucodextran_N,Glyco_hydro_15
REGS1_k127_2575235_0	63737.Npun_R0954	1.125e-212	688.0	COG2366@1|root,COG2366@2|Bacteria,1G4M5@1117|Cyanobacteria,1HU4F@1161|Nostocales	1117|Cyanobacteria	S	penicillin amidase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
REGS1_k127_2575235_3	635013.TherJR_0220	4.603e-46	178.0	COG0340@1|root,COG1654@1|root,COG0340@2|Bacteria,COG1654@2|Bacteria,1TQCU@1239|Firmicutes,248CK@186801|Clostridia,260CI@186807|Peptococcaceae	186801|Clostridia	HK	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB,HTH_11
REGS1_k127_2575235_2	1173028.ANKO01000120_gene2770	3.274e-123	403.0	COG1052@1|root,COG1052@2|Bacteria,1G1BP@1117|Cyanobacteria,1HED5@1150|Oscillatoriales	1117|Cyanobacteria	C	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	-	-	1.1.1.26,1.20.1.1	ko:K00015,ko:K18916	ko00630,ko01100,ko01110,ko01120,map00630,map01100,map01110,map01120	-	R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
REGS1_k127_2575235_6	698757.Pogu_0546	0.0002177	44.0	COG0537@1|root,arCOG00419@2157|Archaea,2XQK8@28889|Crenarchaeota	28889|Crenarchaeota	F	PFAM histidine triad (HIT) protein	-	-	2.7.7.53	ko:K19710	ko00230,map00230	-	R00126,R01618	RC00002,RC02753,RC02795	ko00000,ko00001,ko01000	-	-	-	HIT
REGS1_k127_2585143_0	926569.ANT_08530	1.185e-112	371.0	COG1087@1|root,COG1087@2|Bacteria,2G8A8@200795|Chloroflexi	200795|Chloroflexi	M	NAD(P)H-binding	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
REGS1_k127_2585143_2	357808.RoseRS_3344	3.934e-68	240.0	COG0846@1|root,COG0846@2|Bacteria,2G6QQ@200795|Chloroflexi,375GJ@32061|Chloroflexia	32061|Chloroflexia	K	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form	-	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
REGS1_k127_2585143_1	864702.OsccyDRAFT_2488	4.141e-70	244.0	COG1515@1|root,COG1515@2|Bacteria,1G2HF@1117|Cyanobacteria,1H8TY@1150|Oscillatoriales	1117|Cyanobacteria	L	DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA	nfi	-	3.1.21.7	ko:K05982	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Endonuclease_5
REGS1_k127_2585143_5	525904.Tter_0999	0.0005682	49.0	COG1560@1|root,COG1560@2|Bacteria,2NPD7@2323|unclassified Bacteria	2|Bacteria	M	Lipid A biosynthesis	htrB	GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016746,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.3.1.241,2.3.1.265	ko:K02517,ko:K22311	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
REGS1_k127_2586049_6	1346791.M529_07780	1.591e-05	47.0	COG3549@1|root,COG3549@2|Bacteria,1MZKX@1224|Proteobacteria,2UBQF@28211|Alphaproteobacteria,2K6HV@204457|Sphingomonadales	204457|Sphingomonadales	S	RelE-like toxin of type II toxin-antitoxin system HigB	-	-	-	ko:K07334	-	-	-	-	ko00000,ko02048	-	-	-	HigB-like_toxin
REGS1_k127_2586049_2	926569.ANT_06070	7.815e-61	226.0	COG1181@1|root,COG1181@2|Bacteria,2G5RS@200795|Chloroflexi	200795|Chloroflexi	F	Belongs to the D-alanine--D-alanine ligase family	-	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
REGS1_k127_2586049_0	1444309.JAQG01000025_gene3776	7.086e-158	511.0	COG1509@1|root,COG1509@2|Bacteria,1TQQZ@1239|Firmicutes,4HE2P@91061|Bacilli,26RVM@186822|Paenibacillaceae	91061|Bacilli	E	radical SAM protein	kamA	-	5.4.3.2	ko:K01843	ko00310,map00310	-	R00461	RC00303	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,LAM_C,Radical_SAM
REGS1_k127_2586049_1	1382306.JNIM01000001_gene385	3.403e-65	230.0	COG0569@1|root,COG0569@2|Bacteria,2G6J8@200795|Chloroflexi	200795|Chloroflexi	C	PFAM TrkA-N domain protein	-	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
REGS1_k127_2586049_4	485913.Krac_8326	1.632e-43	163.0	COG0569@1|root,COG0569@2|Bacteria,2G71A@200795|Chloroflexi	200795|Chloroflexi	C	PFAM TrkA-N domain protein	-	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_N
REGS1_k127_2586049_5	485913.Krac_8186	1.323e-17	90.0	COG0589@1|root,COG0589@2|Bacteria,2G7D7@200795|Chloroflexi	200795|Chloroflexi	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
REGS1_k127_2586049_3	525904.Tter_2069	1.534e-46	174.0	COG0531@1|root,COG0531@2|Bacteria,2NNZQ@2323|unclassified Bacteria	2|Bacteria	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
REGS1_k127_2596227_1	1198114.AciX9_0637	2.842e-16	82.0	COG3536@1|root,COG3536@2|Bacteria,3Y4UI@57723|Acidobacteria,2JJF2@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein of unknown function (DUF971)	-	-	-	-	-	-	-	-	-	-	-	-	DUF971
REGS1_k127_2596227_0	926550.CLDAP_39300	7.365e-98	349.0	COG1305@1|root,COG1305@2|Bacteria,2G66M@200795|Chloroflexi	200795|Chloroflexi	E	PFAM transglutaminase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF4129,Transglut_core
REGS1_k127_2602818_1	269799.Gmet_2437	4.318e-92	308.0	COG0745@1|root,COG0745@2|Bacteria,1MWZ5@1224|Proteobacteria,42QTM@68525|delta/epsilon subdivisions,2WN5R@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Two component transcriptional regulator, winged helix family	kdpE	-	-	ko:K07667	ko02020,ko02024,map02020,map02024	M00454	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
REGS1_k127_2602818_2	562970.Btus_0569	6.487e-89	301.0	COG0745@1|root,COG0745@2|Bacteria,1UDAQ@1239|Firmicutes,4HEFU@91061|Bacilli,279EG@186823|Alicyclobacillaceae	91061|Bacilli	K	Two component transcriptional regulator, winged helix family	kdpE	-	-	ko:K07667	ko02020,ko02024,map02020,map02024	M00454	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
REGS1_k127_2602818_0	243231.GSU2483	1.721e-114	388.0	COG0642@1|root,COG2205@2|Bacteria,1MUZQ@1224|Proteobacteria,42NZF@68525|delta/epsilon subdivisions,2WJNR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase	kdpD	-	2.7.13.3	ko:K07646	ko02020,map02020	M00454	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF4118,GAF_3,HATPase_c,HisKA,KdpD,Usp
REGS1_k127_2602818_5	1379698.RBG1_1C00001G0745	2.615e-07	54.0	COG1574@1|root,COG1574@2|Bacteria,2NNTF@2323|unclassified Bacteria	2|Bacteria	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
REGS1_k127_2602818_4	644966.Tmar_1104	1.665e-27	119.0	COG1310@1|root,COG1310@2|Bacteria,1V6TY@1239|Firmicutes,24JI8@186801|Clostridia	186801|Clostridia	S	Mov34 MPN PAD-1 family	-	-	3.13.1.6	ko:K21140	ko04122,map04122	-	R11524	RC00064,RC00090	ko00000,ko00001,ko01000	-	-	-	Prok-JAB
REGS1_k127_2602818_3	357808.RoseRS_0866	9.41e-34	136.0	COG0407@1|root,COG0407@2|Bacteria,2G6BE@200795|Chloroflexi,377BZ@32061|Chloroflexia	32061|Chloroflexia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
REGS1_k127_262610_1	543734.LCABL_02740	2.145e-79	272.0	COG0274@1|root,COG0274@2|Bacteria,1TPAJ@1239|Firmicutes,4HAAJ@91061|Bacilli,3F4M3@33958|Lactobacillaceae	91061|Bacilli	F	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate	deoC	-	4.1.2.4	ko:K01619	ko00030,map00030	-	R01066	RC00436,RC00437	ko00000,ko00001,ko01000	-	-	-	DeoC,NUDIX
REGS1_k127_262610_3	1121087.AUCK01000005_gene726	2.298e-22	99.0	COG4576@1|root,COG4576@2|Bacteria,1VEI4@1239|Firmicutes,4IKXG@91061|Bacilli,1ZI7Q@1386|Bacillus	91061|Bacilli	CQ	Ethanolamine utilisation protein EutN/carboxysome	-	-	-	-	-	-	-	-	-	-	-	-	EutN_CcmL
REGS1_k127_262610_2	316274.Haur_0836	6.326e-51	194.0	COG3597@1|root,COG3597@2|Bacteria,2G9CM@200795|Chloroflexi,375HR@32061|Chloroflexia	32061|Chloroflexia	S	protein domain associated with	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_262610_0	926569.ANT_07220	3.137e-107	357.0	COG1012@1|root,COG1012@2|Bacteria	2|Bacteria	C	belongs to the aldehyde dehydrogenase family	eutE	-	1.2.1.10	ko:K00132	ko00620,ko00650,ko01100,ko01120,map00620,map00650,map01100,map01120	-	R00228,R01172	RC00004,RC00184,RC01195	ko00000,ko00001,ko01000	-	-	-	Aldedh
REGS1_k127_2648109_0	926569.ANT_14560	1.762e-83	291.0	COG0790@1|root,COG3359@1|root,COG0790@2|Bacteria,COG3359@2|Bacteria,2G6TK@200795|Chloroflexi	200795|Chloroflexi	L	RNase_H superfamily	-	-	-	ko:K07502	-	-	-	-	ko00000	-	-	-	RNase_H_2
REGS1_k127_2648109_2	479434.Sthe_2019	3.259e-41	165.0	COG0726@1|root,COG0726@2|Bacteria,2G6VJ@200795|Chloroflexi,27Y6A@189775|Thermomicrobia	189775|Thermomicrobia	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
REGS1_k127_2648109_3	926550.CLDAP_29830	3.344e-35	157.0	COG0739@1|root,COG0739@2|Bacteria	2|Bacteria	M	heme binding	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Glucosaminidase,Peptidase_M23,Peptidase_M56,SLT
REGS1_k127_2648109_1	1379698.RBG1_1C00001G0703	1.106e-64	228.0	COG0124@1|root,COG0124@2|Bacteria,2NNZ7@2323|unclassified Bacteria	2|Bacteria	J	Histidyl-tRNA synthetase	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
REGS1_k127_2649414_5	1120999.JONM01000001_gene1491	1.393e-52	190.0	COG1914@1|root,COG1914@2|Bacteria,1MW6X@1224|Proteobacteria,2VK6I@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Natural resistance-associated macrophage protein	-	-	-	-	-	-	-	-	-	-	-	-	Nramp
REGS1_k127_2649414_14	370438.PTH_0397	1.513e-08	61.0	COG2026@1|root,COG2026@2|Bacteria,1VBJJ@1239|Firmicutes,24NYG@186801|Clostridia,2638D@186807|Peptococcaceae	186801|Clostridia	DJ	Addiction module toxin, RelE StbE family	-	-	-	-	-	-	-	-	-	-	-	-	ParE_toxin,YafQ_toxin
REGS1_k127_2649414_10	1133849.O3I_014700	7.45e-14	76.0	2C98M@1|root,2ZFXA@2|Bacteria,2HIR3@201174|Actinobacteria,4G4KF@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_2649414_4	1463841.JOIR01000018_gene1022	5.148e-58	216.0	COG4402@1|root,COG4402@2|Bacteria,2I90K@201174|Actinobacteria	201174|Actinobacteria	S	Uncharacterized protein conserved in bacteria (DUF2330)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2330
REGS1_k127_2649414_6	306281.AJLK01000113_gene466	4.379e-48	178.0	COG1247@1|root,COG1247@2|Bacteria,1G5X1@1117|Cyanobacteria	1117|Cyanobacteria	M	Acetyltransferase, gnat family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,FR47
REGS1_k127_2649414_1	926550.CLDAP_17420	4.823e-230	734.0	COG1331@1|root,COG1331@2|Bacteria,2G5R1@200795|Chloroflexi	200795|Chloroflexi	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	GlcNAc_2-epim,Thioredox_DsbH
REGS1_k127_2649414_9	1382306.JNIM01000001_gene2330	2.736e-14	74.0	COG0365@1|root,COG0365@2|Bacteria,2G83G@200795|Chloroflexi	200795|Chloroflexi	I	Acetyl-coenzyme A synthetase N-terminus	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
REGS1_k127_2649414_11	1382306.JNIM01000001_gene466	1.281e-12	69.0	COG1331@1|root,COG1331@2|Bacteria,2G5R1@200795|Chloroflexi	200795|Chloroflexi	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	GlcNAc_2-epim,Thioredox_DsbH
REGS1_k127_2649414_7	292459.STH551	5.216e-46	174.0	2BZ6R@1|root,332GN@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_2649414_12	402777.KB235904_gene3578	1.655e-11	67.0	COG3860@1|root,COG3860@2|Bacteria,1GBAQ@1117|Cyanobacteria	1117|Cyanobacteria	S	GIY-YIG catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	GIY-YIG
REGS1_k127_2649414_13	1382356.JQMP01000004_gene341	3.382e-10	61.0	COG0365@1|root,COG0365@2|Bacteria,2G83G@200795|Chloroflexi,27XZN@189775|Thermomicrobia	189775|Thermomicrobia	I	Acetyl-coenzyme A synthetase N-terminus	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
REGS1_k127_2649414_8	376733.IT41_01945	1.622e-17	87.0	COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,2TRFZ@28211|Alphaproteobacteria,2PU9G@265|Paracoccus	28211|Alphaproteobacteria	T	Transcriptional regulatory protein, C terminal	phoB	-	-	ko:K07657	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
REGS1_k127_2649414_0	485913.Krac_2635	7.145e-260	837.0	COG0457@1|root,COG3629@1|root,COG3899@1|root,COG0457@2|Bacteria,COG3629@2|Bacteria,COG3899@2|Bacteria,2G871@200795|Chloroflexi	200795|Chloroflexi	K	Transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD,TPR_12
REGS1_k127_2649414_3	1380355.JNIJ01000012_gene1054	5.286e-61	222.0	COG2010@1|root,COG2010@2|Bacteria,1MXXQ@1224|Proteobacteria,2U38E@28211|Alphaproteobacteria,3JU2K@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
REGS1_k127_2649414_2	485913.Krac_10552	1.653e-67	246.0	COG4585@1|root,COG4585@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
REGS1_k127_2649414_15	485913.Krac_6021	0.0006046	45.0	COG4585@1|root,COG4585@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
REGS1_k127_2683124_2	292459.STH2612	1.168e-13	76.0	COG0642@1|root,COG2205@2|Bacteria,1TRAB@1239|Firmicutes,24DV3@186801|Clostridia	186801|Clostridia	T	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	DUF4173
REGS1_k127_2683124_1	485913.Krac_2501	9.853e-42	161.0	2EC7T@1|root,3366B@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_2683124_0	309801.trd_0354	1.187e-132	436.0	COG0621@1|root,COG0621@2|Bacteria,2G5QK@200795|Chloroflexi,27Y2T@189775|Thermomicrobia	189775|Thermomicrobia	H	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
REGS1_k127_2683124_3	582899.Hden_3367	1.514e-13	75.0	COG0500@1|root,COG2226@2|Bacteria,1PN45@1224|Proteobacteria,2U64U@28211|Alphaproteobacteria,3N9ET@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
REGS1_k127_2691602_3	65393.PCC7424_5350	7.405e-22	98.0	COG0247@1|root,COG0247@2|Bacteria,1G12G@1117|Cyanobacteria,3KHBN@43988|Cyanothece	1117|Cyanobacteria	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	glcF	-	-	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	iAPECO1_1312.glcF,iJN678.glcF,iUTI89_1310.glcF,ic_1306.glcF	CCG,Fer4_7,Fer4_8
REGS1_k127_2691602_1	485913.Krac_10288	1.664e-72	259.0	COG0277@1|root,COG0277@2|Bacteria,2G6FW@200795|Chloroflexi	200795|Chloroflexi	C	PFAM FAD linked oxidase domain protein	-	-	-	ko:K11472	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	FAD-oxidase_C,FAD_binding_4
REGS1_k127_2691602_0	1382306.JNIM01000001_gene1617	7.689e-164	529.0	COG0277@1|root,COG0277@2|Bacteria,2G5TM@200795|Chloroflexi	200795|Chloroflexi	C	PFAM FAD linked oxidase domain protein	-	-	1.1.2.4,1.1.3.15	ko:K00102,ko:K00104	ko00620,ko00630,ko01100,ko01110,ko01120,ko01130,map00620,map00630,map01100,map01110,map01120,map01130	-	R00197,R00475	RC00042,RC00044	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
REGS1_k127_2691602_2	1040989.AWZU01000003_gene6623	1.744e-55	196.0	COG0395@1|root,COG0395@2|Bacteria,1N4I0@1224|Proteobacteria,2U0UX@28211|Alphaproteobacteria,3JWP8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
REGS1_k127_2696842_8	479434.Sthe_3030	3.474e-91	315.0	COG0285@1|root,COG0285@2|Bacteria,2G64M@200795|Chloroflexi,27Y4Y@189775|Thermomicrobia	189775|Thermomicrobia	H	Mur ligase family, glutamate ligase domain	-	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M
REGS1_k127_2696842_4	234267.Acid_3219	1.61e-129	443.0	COG4447@1|root,COG4447@2|Bacteria,3Y4R8@57723|Acidobacteria	57723|Acidobacteria	O	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_2696842_9	479434.Sthe_0899	1.572e-85	295.0	COG3872@1|root,COG3872@2|Bacteria,2G5XQ@200795|Chloroflexi,27XQ4@189775|Thermomicrobia	189775|Thermomicrobia	S	Protein of unknown function (DUF1385)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1385
REGS1_k127_2696842_7	666685.R2APBS1_1154	8.017e-101	347.0	COG3055@1|root,COG3055@2|Bacteria,1NHAC@1224|Proteobacteria,1RYBY@1236|Gammaproteobacteria,1XAGU@135614|Xanthomonadales	135614|Xanthomonadales	S	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_2696842_0	1173028.ANKO01000250_gene2300	2.912e-222	700.0	COG1866@1|root,COG1866@2|Bacteria,1G1KI@1117|Cyanobacteria,1H944@1150|Oscillatoriales	1117|Cyanobacteria	H	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA	-	-	4.1.1.49	ko:K01610	ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00170	R00341	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_ATP
REGS1_k127_2696842_11	1128421.JAGA01000002_gene426	1.418e-11	70.0	COG1917@1|root,COG1917@2|Bacteria,2NRCD@2323|unclassified Bacteria	2|Bacteria	S	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
REGS1_k127_2696842_5	1382306.JNIM01000001_gene397	1.488e-117	387.0	COG0039@1|root,COG0039@2|Bacteria,2G61S@200795|Chloroflexi	200795|Chloroflexi	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	-	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
REGS1_k127_2696842_3	479434.Sthe_2769	1.313e-136	446.0	COG0612@1|root,COG0612@2|Bacteria,2G5N3@200795|Chloroflexi,27XVK@189775|Thermomicrobia	189775|Thermomicrobia	S	Insulinase (Peptidase family M16)	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
REGS1_k127_2696842_6	316274.Haur_2806	4.851e-104	353.0	COG0612@1|root,COG0612@2|Bacteria,2G5N3@200795|Chloroflexi,37674@32061|Chloroflexia	32061|Chloroflexia	S	PFAM peptidase M16 domain protein	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
REGS1_k127_2696842_2	1303518.CCALI_00259	3.824e-163	520.0	COG0473@1|root,COG0473@2|Bacteria	2|Bacteria	CE	3-isopropylmalate dehydrogenase activity	icd	-	1.1.1.41	ko:K00030	ko00020,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010	R00709	RC00114	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
REGS1_k127_2696842_1	1192034.CAP_3742	6.675e-216	678.0	COG0538@1|root,COG0538@2|Bacteria,1MW3J@1224|Proteobacteria,42M56@68525|delta/epsilon subdivisions,2WJ8W@28221|Deltaproteobacteria,2YYDJ@29|Myxococcales	28221|Deltaproteobacteria	C	Isocitrate/isopropylmalate dehydrogenase	icd	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
REGS1_k127_2696842_10	926550.CLDAP_34110	8.629e-20	98.0	COG1305@1|root,COG1305@2|Bacteria,2G66M@200795|Chloroflexi	200795|Chloroflexi	E	PFAM transglutaminase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
REGS1_k127_270368_4	1125863.JAFN01000001_gene2355	3.816e-36	152.0	COG3210@1|root,COG5492@1|root,COG3210@2|Bacteria,COG5492@2|Bacteria,1PFJ7@1224|Proteobacteria,42WVE@68525|delta/epsilon subdivisions	1224|Proteobacteria	N	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_270368_3	717605.Theco_1387	7.266e-47	178.0	COG2345@1|root,COG2345@2|Bacteria,1V5Q5@1239|Firmicutes,4HHMX@91061|Bacilli,26U3B@186822|Paenibacillaceae	91061|Bacilli	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_11,HTH_20,HTH_24,HTH_5,HTH_DeoR
REGS1_k127_270368_2	485913.Krac_12461	2.1e-97	329.0	COG2355@1|root,COG2355@2|Bacteria,2G6FQ@200795|Chloroflexi	200795|Chloroflexi	E	Membrane dipeptidase (Peptidase family M19)	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
REGS1_k127_270368_1	926560.KE387023_gene2478	8.87e-98	324.0	COG0346@1|root,COG1028@1|root,COG0346@2|Bacteria,COG1028@2|Bacteria,1WI3C@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	IQ	Short-chain Dehydrogenase reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
REGS1_k127_270368_0	1121377.KB906405_gene135	4.807e-145	467.0	COG0809@1|root,COG0809@2|Bacteria,1WJW8@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	J	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	-	-	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
REGS1_k127_270368_5	102129.Lepto7375DRAFT_8109	4.63e-23	100.0	COG2162@1|root,COG2162@2|Bacteria,1G6IN@1117|Cyanobacteria,1HHR2@1150|Oscillatoriales	1117|Cyanobacteria	H	Belongs to the arylamine N-acetyltransferase family	-	-	2.3.1.118	ko:K00675	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_2
REGS1_k127_2717041_3	1392489.JPOL01000002_gene3354	7.902e-19	87.0	COG1028@1|root,COG1028@2|Bacteria,4PKM5@976|Bacteroidetes,1HYF7@117743|Flavobacteriia	976|Bacteroidetes	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.3.1.10,1.3.1.9	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
REGS1_k127_2717041_1	1120973.AQXL01000135_gene1333	1.517e-57	215.0	COG0491@1|root,COG0491@2|Bacteria,1TQPX@1239|Firmicutes,4HAV6@91061|Bacilli,27956@186823|Alicyclobacillaceae	91061|Bacilli	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
REGS1_k127_2717041_2	309801.trd_0814	1.114e-31	128.0	COG0736@1|root,COG0736@2|Bacteria,2G73N@200795|Chloroflexi,27YDS@189775|Thermomicrobia	189775|Thermomicrobia	I	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein	acpS	-	2.7.8.7	ko:K00997	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
REGS1_k127_2717041_0	926569.ANT_27250	1.93e-177	566.0	COG1004@1|root,COG1004@2|Bacteria,2G62F@200795|Chloroflexi	200795|Chloroflexi	C	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	-	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
REGS1_k127_2761736_2	797209.ZOD2009_20687	2.531e-102	356.0	COG1501@1|root,arCOG03663@2157|Archaea,2XV49@28890|Euryarchaeota,23V0G@183963|Halobacteria	183963|Halobacteria	G	Melibiase	-	-	3.2.1.22	ko:K07407	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	Melibiase
REGS1_k127_2761736_3	398767.Glov_2097	7.204e-64	239.0	COG0747@1|root,COG0747@2|Bacteria,1R7KU@1224|Proteobacteria	1224|Proteobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
REGS1_k127_2761736_1	479434.Sthe_0728	2.733e-116	389.0	COG0019@1|root,COG0019@2|Bacteria,2G5RR@200795|Chloroflexi,27XZ6@189775|Thermomicrobia	189775|Thermomicrobia	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
REGS1_k127_2761736_5	661478.OP10G_4153	1.385e-30	138.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
REGS1_k127_2761736_0	485913.Krac_4895	7.819e-126	416.0	COG0477@1|root,COG2814@2|Bacteria,2G8CV@200795|Chloroflexi	2|Bacteria	EGP	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
REGS1_k127_2761736_4	63737.Npun_F4627	1.403e-54	199.0	COG0586@1|root,COG0586@2|Bacteria,1G4C6@1117|Cyanobacteria,1HIII@1161|Nostocales	1117|Cyanobacteria	S	SNARE associated Golgi protein	-	-	-	ko:K03975	-	-	-	-	ko00000	-	-	-	SNARE_assoc
REGS1_k127_2763096_2	706587.Desti_2109	1.003e-28	118.0	COG0166@1|root,COG0176@1|root,COG0166@2|Bacteria,COG0176@2|Bacteria,1MUFP@1224|Proteobacteria,42MNB@68525|delta/epsilon subdivisions,2WIXQ@28221|Deltaproteobacteria,2MRG0@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	Belongs to the GPI family	pgi	-	2.2.1.2,5.3.1.9	ko:K01810,ko:K13810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00004,M00007,M00114	R01827,R02739,R02740,R03321	RC00376,RC00439,RC00563,RC00604	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI
REGS1_k127_2763096_0	1123242.JH636434_gene3809	7.236e-56	200.0	COG0698@1|root,COG0698@2|Bacteria,2IZSB@203682|Planctomycetes	203682|Planctomycetes	G	Ribose/Galactose Isomerase	-	-	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	LacAB_rpiB
REGS1_k127_2763096_1	1123060.JONP01000032_gene1861	1.569e-43	161.0	COG5507@1|root,COG5507@2|Bacteria,1RH3Q@1224|Proteobacteria,2U9SM@28211|Alphaproteobacteria,2JWSY@204441|Rhodospirillales	204441|Rhodospirillales	S	NIPSNAP	-	-	-	-	-	-	-	-	-	-	-	-	NIPSNAP
REGS1_k127_2767399_0	526227.Mesil_0382	3.345e-148	481.0	COG1505@1|root,COG1505@2|Bacteria,1WMDW@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	Prolyl oligopeptidase, N-terminal beta-propeller domain	-	-	3.4.21.26	ko:K01322	ko04614,map04614	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
REGS1_k127_2767399_1	760568.Desku_2298	4.35e-88	301.0	COG0416@1|root,COG0416@2|Bacteria,1TPXS@1239|Firmicutes,247KW@186801|Clostridia,2610G@186807|Peptococcaceae	186801|Clostridia	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA	plsX	-	2.3.1.15	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_synthesis
REGS1_k127_2767399_2	1501230.ET33_17020	2.876e-43	171.0	COG1307@1|root,COG1307@2|Bacteria,1TRM7@1239|Firmicutes,4HBIR@91061|Bacilli,26S8K@186822|Paenibacillaceae	91061|Bacilli	S	DegV family	degV3	-	-	-	-	-	-	-	-	-	-	-	DegV
REGS1_k127_2767399_3	485913.Krac_10314	0.000191	50.0	COG1718@1|root,COG1718@2|Bacteria	2|Bacteria	DT	cellular response to dsDNA	IV02_22125	-	2.7.11.1	ko:K07178	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko01001,ko03009	-	-	-	RIO1
REGS1_k127_2778127_1	870187.Thini_2057	1.507e-42	157.0	COG0179@1|root,COG0179@2|Bacteria,1MUPF@1224|Proteobacteria,1RPYA@1236|Gammaproteobacteria,460GJ@72273|Thiotrichales	72273|Thiotrichales	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
REGS1_k127_2778127_0	1125863.JAFN01000001_gene3450	6.748e-116	391.0	COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,42MGY@68525|delta/epsilon subdivisions,2WJHC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	TIGRFAM glutamate synthase (NADPH), homotetrameric	-	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
REGS1_k127_2788372_1	123214.PERMA_1536	7.73e-09	60.0	arCOG07300@1|root,2ZTGG@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_2788372_0	880072.Desac_2179	2.08e-10	68.0	COG0468@1|root,COG0468@2|Bacteria	2|Bacteria	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	-	-	-	-	-	-	-	-	-	-	-	-	AAA_12,AAA_24,AAA_25,DUF4011
REGS1_k127_2788372_2	471852.Tcur_1998	1.656e-07	58.0	COG2909@1|root,COG3899@1|root,COG2909@2|Bacteria,COG3899@2|Bacteria,2GM1B@201174|Actinobacteria,4EN8C@85012|Streptosporangiales	201174|Actinobacteria	K	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
REGS1_k127_2804990_0	926550.CLDAP_04520	2.882e-88	302.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,2G5Y8@200795|Chloroflexi	200795|Chloroflexi	H	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
REGS1_k127_2804990_1	439496.RBY4I_419	4.022e-30	134.0	COG1594@1|root,COG1594@2|Bacteria,1MWK8@1224|Proteobacteria,2U0YM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	COG1198 Primosomal protein N' (replication factor Y) - superfamily II helicase	-	-	-	-	-	-	-	-	-	-	-	-	zf-RRN7
REGS1_k127_2804990_2	215803.DB30_4251	2.462e-16	93.0	COG1404@1|root,COG3055@1|root,COG3291@1|root,COG3509@1|root,COG5295@1|root,COG1404@2|Bacteria,COG3055@2|Bacteria,COG3291@2|Bacteria,COG3509@2|Bacteria,COG5295@2|Bacteria,1Q4PP@1224|Proteobacteria,42YRG@68525|delta/epsilon subdivisions,2WUJR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Bacterial Ig-like domain (group 3)	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_3
REGS1_k127_281562_1	926550.CLDAP_17520	7.819e-08	64.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
REGS1_k127_281562_0	373903.Hore_17270	2.679e-108	371.0	COG3379@1|root,COG3379@2|Bacteria,1VHYF@1239|Firmicutes,24VS8@186801|Clostridia	186801|Clostridia	Q	type I phosphodiesterase nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
REGS1_k127_2818456_1	768710.DesyoDRAFT_2996	1.149e-51	189.0	COG0484@1|root,COG0484@2|Bacteria,1TS44@1239|Firmicutes,24A9N@186801|Clostridia,2616G@186807|Peptococcaceae	186801|Clostridia	O	DnaJ-class molecular chaperone with C-terminal Zn finger domain	CbpA	-	-	ko:K05516	-	-	-	-	ko00000,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C
REGS1_k127_2818456_5	1122221.JHVI01000004_gene182	5.056e-29	121.0	COG0789@1|root,COG0789@2|Bacteria,1WJ4G@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	K	PFAM MerR family regulatory protein	-	-	-	ko:K13640	-	-	-	-	ko00000,ko03000	-	-	-	MerR_1
REGS1_k127_2818456_4	518766.Rmar_2532	4.496e-29	130.0	COG1503@1|root,COG1503@2|Bacteria	2|Bacteria	J	translation release factor activity	-	-	-	ko:K03265	ko03015,map03015	-	-	-	ko00000,ko00001,ko03012,ko03019	-	-	-	PP-binding,eRF1_2,eRF1_3
REGS1_k127_2818456_6	1128421.JAGA01000003_gene2908	2.074e-11	73.0	COG2823@1|root,COG2823@2|Bacteria,2NQTV@2323|unclassified Bacteria	2|Bacteria	S	BON domain	-	-	-	-	-	-	-	-	-	-	-	-	BON,PRC
REGS1_k127_2818456_0	864702.OsccyDRAFT_2330	1.751e-60	218.0	COG0705@1|root,COG0705@2|Bacteria,1FZY1@1117|Cyanobacteria,1H9IP@1150|Oscillatoriales	1117|Cyanobacteria	S	(Rhomboid) family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
REGS1_k127_2818456_3	864702.OsccyDRAFT_2330	1.053e-35	146.0	COG0705@1|root,COG0705@2|Bacteria,1FZY1@1117|Cyanobacteria,1H9IP@1150|Oscillatoriales	1117|Cyanobacteria	S	(Rhomboid) family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
REGS1_k127_2818456_2	227882.SAV_7241	2.031e-46	172.0	COG0542@1|root,COG0542@2|Bacteria,2GJ73@201174|Actinobacteria	201174|Actinobacteria	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB2	-	-	ko:K03695,ko:K03696	ko01100,ko04213,map01100,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
REGS1_k127_2833816_0	926569.ANT_27260	3.157e-132	451.0	COG5427@1|root,COG5427@2|Bacteria,2G6AA@200795|Chloroflexi	200795|Chloroflexi	S	Uncharacterized membrane protein (DUF2298)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2298
REGS1_k127_2833816_1	357808.RoseRS_0659	0.0003166	44.0	COG0457@1|root,COG5427@1|root,COG0457@2|Bacteria,COG5427@2|Bacteria,2G5UJ@200795|Chloroflexi,37551@32061|Chloroflexia	32061|Chloroflexia	M	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF2298,PMT_2,TPR_16,TPR_19,TPR_8
REGS1_k127_2840582_4	986075.CathTA2_1716	1.503e-64	245.0	COG2046@1|root,COG2046@2|Bacteria,1TR4C@1239|Firmicutes,4HC20@91061|Bacilli	91061|Bacilli	P	the enzyme from Thermus thermophilus is dimeric and binds a zinc ion that is coordinated by cysteine and histidine residues that are not found in all related proteins but is found in some thermophilic organisms	sat	-	2.7.7.4	ko:K00958	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-sulfurylase,PUA_2
REGS1_k127_2840582_0	867845.KI911784_gene1404	3.543e-160	527.0	COG3119@1|root,COG3379@1|root,COG3119@2|Bacteria,COG3379@2|Bacteria,2GBS6@200795|Chloroflexi,376DT@32061|Chloroflexia	32061|Chloroflexia	P	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
REGS1_k127_2840582_3	398767.Glov_0611	9.788e-70	239.0	COG1803@1|root,COG1803@2|Bacteria,1RD3D@1224|Proteobacteria,42SPC@68525|delta/epsilon subdivisions,2WP55@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	TIGRFAM Methylglyoxal synthase	mgsA	-	4.2.3.3	ko:K01734	ko00640,ko01120,map00640,map01120	-	R01016	RC00424	ko00000,ko00001,ko01000	-	-	-	MGS
REGS1_k127_2840582_2	1254432.SCE1572_34170	2.287e-72	250.0	COG0529@1|root,COG2046@1|root,COG0529@2|Bacteria,COG2046@2|Bacteria,1MUQB@1224|Proteobacteria,42NAI@68525|delta/epsilon subdivisions,2WJYY@28221|Deltaproteobacteria,2Z30P@29|Myxococcales	28221|Deltaproteobacteria	F	Belongs to the	sat	-	2.7.1.25,2.7.7.4	ko:K00958,ko:K13811	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00509,R00529,R04928,R04929	RC00002,RC00078,RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-sulfurylase,PUA_2
REGS1_k127_2840582_1	1121272.KB903253_gene6883	9.83e-82	280.0	COG0673@1|root,COG0673@2|Bacteria,2GJCY@201174|Actinobacteria,4DCYX@85008|Micromonosporales	201174|Actinobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
REGS1_k127_2885730_11	666685.R2APBS1_0110	2.48e-42	158.0	COG5483@1|root,COG5483@2|Bacteria,1RDGV@1224|Proteobacteria,1SBHQ@1236|Gammaproteobacteria,1X6JD@135614|Xanthomonadales	135614|Xanthomonadales	S	Protein of unknown function, DUF488	-	-	-	-	-	-	-	-	-	-	-	-	DUF488
REGS1_k127_2885730_7	1134474.O59_002436	2.683e-73	255.0	COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,1RPRD@1236|Gammaproteobacteria,1FHT1@10|Cellvibrio	1236|Gammaproteobacteria	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
REGS1_k127_2885730_16	404589.Anae109_1050	4.498e-07	53.0	COG0604@1|root,COG0604@2|Bacteria,1PFUG@1224|Proteobacteria,43DPN@68525|delta/epsilon subdivisions,2X9UD@28221|Deltaproteobacteria,2Z058@29|Myxococcales	28221|Deltaproteobacteria	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N_2
REGS1_k127_2885730_15	760192.Halhy_5287	1.218e-09	61.0	COG1529@1|root,COG1529@2|Bacteria,4NFF5@976|Bacteroidetes,1IVK4@117747|Sphingobacteriia	976|Bacteroidetes	C	COGs COG1529 Aerobic-type carbon monoxide dehydrogenase large subunit CoxL CutL homologs	-	-	1.17.1.4,1.2.5.3	ko:K03520,ko:K11177	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103,R11168	RC00143,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
REGS1_k127_2885730_2	1386089.N865_11555	4.66e-208	657.0	COG4409@1|root,COG4409@2|Bacteria	2|Bacteria	G	exo-alpha-(2->6)-sialidase activity	nanA	GO:0001573,GO:0003674,GO:0003824,GO:0004308,GO:0004553,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006629,GO:0006643,GO:0006664,GO:0006665,GO:0006672,GO:0006687,GO:0006689,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009311,GO:0009313,GO:0009987,GO:0016020,GO:0016042,GO:0016052,GO:0016787,GO:0016798,GO:0016997,GO:0019377,GO:0030149,GO:0034641,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043603,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044424,GO:0044464,GO:0046466,GO:0046479,GO:0046514,GO:0071704,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575,GO:1903509	3.2.1.18	ko:K01186	ko00511,ko00600,ko04142,map00511,map00600,map04142	-	R04018	RC00028,RC00077	ko00000,ko00001,ko01000,ko02042	-	GH33	-	BNR_2,Gram_pos_anchor,Sialidase,YSIRK_signal
REGS1_k127_2885730_14	760192.Halhy_5287	8.648e-18	84.0	COG1529@1|root,COG1529@2|Bacteria,4NFF5@976|Bacteroidetes,1IVK4@117747|Sphingobacteriia	976|Bacteroidetes	C	COGs COG1529 Aerobic-type carbon monoxide dehydrogenase large subunit CoxL CutL homologs	-	-	1.17.1.4,1.2.5.3	ko:K03520,ko:K11177	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103,R11168	RC00143,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
REGS1_k127_2885730_12	298655.KI912266_gene2545	1.81e-39	150.0	COG4922@1|root,COG4922@2|Bacteria,2IA0H@201174|Actinobacteria,4EWXQ@85013|Frankiales	201174|Actinobacteria	S	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL,SnoaL_2
REGS1_k127_2885730_0	518766.Rmar_2766	0.0	1227.0	COG1529@1|root,COG1529@2|Bacteria,4NFF5@976|Bacteroidetes	976|Bacteroidetes	C	Aldehyde oxidase and xanthine dehydrogenase a b hammerhead	-	-	1.17.1.4,1.2.5.3	ko:K03520,ko:K11177	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103,R11168	RC00143,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
REGS1_k127_2885730_8	309801.trd_A0565	1.345e-69	240.0	COG2080@1|root,COG2080@2|Bacteria,2GBCT@200795|Chloroflexi,27YT4@189775|Thermomicrobia	189775|Thermomicrobia	C	2Fe-2S -binding domain protein	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2_2
REGS1_k127_2885730_6	760192.Halhy_5285	1.407e-95	320.0	COG1319@1|root,COG1319@2|Bacteria,4NFT8@976|Bacteroidetes,1IV94@117747|Sphingobacteriia	976|Bacteroidetes	C	COGs COG1319 Aerobic-type carbon monoxide dehydrogenase middle subunit CoxM CutM homologs	-	-	1.17.1.4,1.2.5.3	ko:K03519,ko:K11178	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103,R11168	RC00143,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
REGS1_k127_2885730_3	485913.Krac_0986	5.959e-188	602.0	COG0492@1|root,COG3437@1|root,COG0492@2|Bacteria,COG3437@2|Bacteria,2G5Z5@200795|Chloroflexi	200795|Chloroflexi	C	FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Response_reg
REGS1_k127_2885730_9	304371.MCP_0966	1.027e-66	238.0	COG0863@1|root,arCOG00115@2157|Archaea,2Y8E2@28890|Euryarchaeota	28890|Euryarchaeota	L	DNA methylase	-	-	-	-	-	-	-	-	-	-	-	-	N6_N4_Mtase
REGS1_k127_2885730_1	525904.Tter_0081	6.457e-246	779.0	COG3808@1|root,COG3808@2|Bacteria,2NNK9@2323|unclassified Bacteria	2|Bacteria	C	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
REGS1_k127_2885730_10	926569.ANT_16060	1.876e-46	173.0	COG0640@1|root,COG3860@1|root,COG0640@2|Bacteria,COG3860@2|Bacteria,2G8TH@200795|Chloroflexi	200795|Chloroflexi	K	regulatory protein, arsR	-	-	-	-	-	-	-	-	-	-	-	-	DUF2087,HTH_5
REGS1_k127_2885730_5	357808.RoseRS_3749	1.087e-115	391.0	COG0195@1|root,COG0195@2|Bacteria,2G5M5@200795|Chloroflexi,3756H@32061|Chloroflexia	32061|Chloroflexia	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_5,NusA_N,S1
REGS1_k127_2885730_13	316274.Haur_0474	2.384e-19	93.0	COG2740@1|root,COG2740@2|Bacteria,2G72H@200795|Chloroflexi,375YN@32061|Chloroflexia	32061|Chloroflexia	K	Protein of unknown function (DUF448)	-	-	-	ko:K07742	-	-	-	-	ko00000	-	-	-	DUF448
REGS1_k127_2885730_4	1121468.AUBR01000029_gene1569	1.713e-168	556.0	COG0532@1|root,COG0532@2|Bacteria,1TPAI@1239|Firmicutes,248SJ@186801|Clostridia,42EP2@68295|Thermoanaerobacterales	186801|Clostridia	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
REGS1_k127_288609_2	525904.Tter_0098	2.526e-17	82.0	COG0477@1|root,COG2814@2|Bacteria,2NQP3@2323|unclassified Bacteria	2|Bacteria	EGP	Transmembrane secretion effector	entS	-	-	ko:K08225	-	-	-	-	ko00000,ko02000	2.A.1.38	-	-	MFS_1,MFS_3
REGS1_k127_288609_1	515635.Dtur_0567	1.581e-17	91.0	28XDT@1|root,2ZJBI@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_288609_4	309799.DICTH_0418	9.414e-06	53.0	2DC7K@1|root,2ZD61@2|Bacteria	2|Bacteria	P	Small Multidrug Resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	Multi_Drug_Res
REGS1_k127_288609_0	926569.ANT_11950	3.914e-142	464.0	COG0646@1|root,COG0685@1|root,COG0646@2|Bacteria,COG0685@2|Bacteria,2G674@200795|Chloroflexi	200795|Chloroflexi	H	Homocysteine S-methyltransferase	-	-	1.5.1.20,2.1.1.10	ko:K00297,ko:K00547	ko00270,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01523,map00270,map00670,map00720,map01100,map01110,map01120,map01200,map01523	M00377	R00650,R01224,R07168	RC00003,RC00035,RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR,S-methyl_trans
REGS1_k127_2952154_1	1379698.RBG1_1C00001G0120	2.703e-38	157.0	28II6@1|root,2Z8JB@2|Bacteria,2NNT1@2323|unclassified Bacteria	2|Bacteria	S	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_2952154_0	1303518.CCALI_01483	3.139e-72	265.0	COG1070@1|root,COG1070@2|Bacteria	2|Bacteria	G	xylulokinase activity	-	-	2.7.1.12,2.7.1.17,2.7.1.5	ko:K00848,ko:K00851,ko:K00854	ko00030,ko00040,ko00051,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00040,map00051,map01100,map01110,map01120,map01130,map01200	M00014	R01639,R01737,R01902,R03014	RC00002,RC00017,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N,MutL
REGS1_k127_2952154_2	926550.CLDAP_05220	0.0003037	48.0	2ANS9@1|root,31DS7@2|Bacteria,2G7CA@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_2969974_0	1449355.JQNR01000005_gene5856	6.018e-41	156.0	COG2606@1|root,COG2606@2|Bacteria,2IMZE@201174|Actinobacteria	201174|Actinobacteria	G	Aminoacyl-tRNA editing domain	-	-	-	ko:K19055	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_edit
REGS1_k127_2969974_1	316274.Haur_1942	2.449e-30	139.0	COG0457@1|root,COG0457@2|Bacteria,2GB3M@200795|Chloroflexi,377UW@32061|Chloroflexia	32061|Chloroflexia	S	Protein of unknown function (DUF2723)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2723
REGS1_k127_2993544_0	1041930.Mtc_1294	5.183e-99	330.0	COG1914@1|root,arCOG04531@2157|Archaea,2XU6H@28890|Euryarchaeota,2NASS@224756|Methanomicrobia	224756|Methanomicrobia	P	Natural resistance-associated macrophage protein	-	-	-	-	-	-	-	-	-	-	-	-	Nramp
REGS1_k127_2993544_1	386456.JQKN01000011_gene815	4.134e-81	283.0	COG2239@1|root,arCOG00634@2157|Archaea,2XWIB@28890|Euryarchaeota,23PEC@183925|Methanobacteria	183925|Methanobacteria	P	MgtE intracellular N domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,MgtE_N,PRC
REGS1_k127_3040222_3	880072.Desac_1378	1.97e-23	115.0	COG1306@1|root,COG1306@2|Bacteria,1MWBY@1224|Proteobacteria,42NSR@68525|delta/epsilon subdivisions,2WR56@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Putative glycosyl hydrolase domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4015
REGS1_k127_3040222_0	1121468.AUBR01000036_gene1308	1.05e-151	505.0	COG2203@1|root,COG3437@1|root,COG3605@1|root,COG4936@1|root,COG2203@2|Bacteria,COG3437@2|Bacteria,COG3605@2|Bacteria,COG4936@2|Bacteria,1V7YT@1239|Firmicutes,25ET2@186801|Clostridia,42JGC@68295|Thermoanaerobacterales	186801|Clostridia	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HD,PocR,SBP_bac_3
REGS1_k127_3040222_2	926569.ANT_02090	1.56e-29	124.0	29Z2W@1|root,30M0E@2|Bacteria,2G9IN@200795|Chloroflexi	200795|Chloroflexi	S	Family of unknown function (DUF5317)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5317
REGS1_k127_3040222_1	926569.ANT_04770	6.428e-55	200.0	COG2909@1|root,COG3629@1|root,COG2909@2|Bacteria,COG3629@2|Bacteria,2G6RU@200795|Chloroflexi	200795|Chloroflexi	K	Transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,TPR_12
REGS1_k127_3051645_0	926550.CLDAP_35270	1.616e-168	548.0	COG1132@1|root,COG1132@2|Bacteria,2G5QH@200795|Chloroflexi	200795|Chloroflexi	V	PFAM ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
REGS1_k127_3051645_1	1337936.IJ00_06745	4.579e-37	145.0	COG2827@1|root,COG2827@2|Bacteria,1GK2X@1117|Cyanobacteria,1HT5P@1161|Nostocales	1117|Cyanobacteria	L	GIY-YIG catalytic domain	-	-	-	ko:K07461	-	-	-	-	ko00000	-	-	-	GIY-YIG
REGS1_k127_305683_0	261292.Nit79A3_1514	1.236e-127	432.0	COG0383@1|root,COG0383@2|Bacteria,1R3Q8@1224|Proteobacteria	1224|Proteobacteria	G	Alpha-Mannosidase	mngB	GO:0003674,GO:0003824,GO:0004553,GO:0004559,GO:0005975,GO:0005996,GO:0006013,GO:0006464,GO:0006517,GO:0006807,GO:0008150,GO:0008152,GO:0009100,GO:0009987,GO:0015923,GO:0016787,GO:0016798,GO:0019318,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0071704,GO:1901135,GO:1901564	3.2.1.170,3.2.1.24	ko:K01191,ko:K15524	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04131	-	GH38	iEcolC_1368.EcolC_2924,iSF_1195.SF0565,iSFxv_1172.SFxv_0623,iS_1188.S0578	Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C
REGS1_k127_305683_1	926569.ANT_15640	5.302e-45	170.0	COG0619@1|root,COG0619@2|Bacteria,2G8RH@200795|Chloroflexi	200795|Chloroflexi	P	Cobalt transport protein	-	-	-	ko:K16785	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	CbiQ
REGS1_k127_3057719_6	404380.Gbem_0530	7.134e-18	94.0	COG5661@1|root,COG5661@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF922
REGS1_k127_3057719_0	485913.Krac_12470	2.655e-130	422.0	COG1788@1|root,COG1788@2|Bacteria,2G6IM@200795|Chloroflexi	200795|Chloroflexi	I	Coenzyme A transferase	-	-	2.8.3.12	ko:K01039	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
REGS1_k127_3057719_3	485913.Krac_12220	2.009e-45	176.0	COG3396@1|root,COG3396@2|Bacteria,2G9KQ@200795|Chloroflexi	200795|Chloroflexi	S	PFAM phenylacetic acid catabolic family protein	-	-	1.14.13.149	ko:K02611	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001,ko01000	-	-	-	PaaA_PaaC
REGS1_k127_3057719_7	1382306.JNIM01000001_gene266	1.883e-13	74.0	2DDXP@1|root,2ZJQF@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_3057719_5	1382306.JNIM01000001_gene265	6.036e-33	130.0	COG2151@1|root,COG2151@2|Bacteria,2G9PR@200795|Chloroflexi	200795|Chloroflexi	S	Pfam:DUF59	-	-	-	ko:K02612	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001	-	-	-	FeS_assembly_P
REGS1_k127_3057719_1	1382306.JNIM01000001_gene264	1.409e-125	411.0	COG3396@1|root,COG3396@2|Bacteria,2G9AI@200795|Chloroflexi	200795|Chloroflexi	S	PFAM phenylacetic acid catabolic family protein	-	-	1.14.13.149	ko:K02609	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001,ko01000	-	-	-	PaaA_PaaC
REGS1_k127_3057719_2	266117.Rxyl_1748	8.698e-78	269.0	COG1024@1|root,COG1024@2|Bacteria,2GNXD@201174|Actinobacteria,4CQCF@84995|Rubrobacteria	84995|Rubrobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
REGS1_k127_3057719_4	1487921.DP68_05290	2.836e-35	143.0	COG3404@1|root,COG3404@2|Bacteria,1V1X8@1239|Firmicutes,24JZM@186801|Clostridia,36JRA@31979|Clostridiaceae	186801|Clostridia	E	cyclohydrolase	fchA	-	-	-	-	-	-	-	-	-	-	-	FTCD_C
REGS1_k127_3063772_5	765420.OSCT_3114	3.273e-86	293.0	COG1132@1|root,COG1132@2|Bacteria,2G7QD@200795|Chloroflexi,376IN@32061|Chloroflexia	32061|Chloroflexia	P	PFAM ABC transporter related	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
REGS1_k127_3063772_4	406124.ACPC01000048_gene238	5.586e-88	304.0	COG0624@1|root,COG0624@2|Bacteria,1TPSM@1239|Firmicutes,4HD69@91061|Bacilli,1ZDSF@1386|Bacillus	91061|Bacilli	E	Peptidase dimerisation domain	-	-	3.4.17.11	ko:K01295	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
REGS1_k127_3063772_0	316274.Haur_1604	1.369e-137	451.0	COG0577@1|root,COG0577@2|Bacteria,2G65B@200795|Chloroflexi,37660@32061|Chloroflexia	32061|Chloroflexia	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
REGS1_k127_3063772_2	316274.Haur_1603	6.279e-100	331.0	COG1136@1|root,COG1136@2|Bacteria,2G69N@200795|Chloroflexi,376XE@32061|Chloroflexia	32061|Chloroflexia	V	Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
REGS1_k127_3063772_7	316274.Haur_1602	4.826e-72	261.0	COG0845@1|root,COG0845@2|Bacteria,2G8US@200795|Chloroflexi,3771R@32061|Chloroflexia	32061|Chloroflexia	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3
REGS1_k127_3063772_10	479434.Sthe_2135	2.959e-26	115.0	COG1846@1|root,COG1846@2|Bacteria,2G7D6@200795|Chloroflexi,27Z9E@189775|Thermomicrobia	189775|Thermomicrobia	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2
REGS1_k127_3063772_3	485913.Krac_3353	3.99e-96	324.0	COG0604@1|root,COG0604@2|Bacteria	2|Bacteria	C	NADPH:quinone reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N_2
REGS1_k127_3063772_8	1123368.AUIS01000003_gene1806	4.589e-44	168.0	COG4319@1|root,COG4319@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440,LUD_dom,SnoaL_3,SnoaL_4
REGS1_k127_3063772_11	35754.JNYJ01000061_gene2413	3.485e-22	100.0	2CRSQ@1|root,32SPK@2|Bacteria,2I1XA@201174|Actinobacteria,4DDXB@85008|Micromonosporales	201174|Actinobacteria	S	DoxX-like family	-	-	-	-	-	-	-	-	-	-	-	-	DoxX_2
REGS1_k127_3063772_9	266117.Rxyl_1792	5.069e-35	141.0	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	tetR	-	-	-	-	-	-	-	-	-	-	-	TetR_C_8,TetR_N
REGS1_k127_3063772_1	867845.KI911784_gene1691	3.009e-123	406.0	COG0484@1|root,COG0484@2|Bacteria,2G5NV@200795|Chloroflexi,374VC@32061|Chloroflexia	32061|Chloroflexia	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
REGS1_k127_3063772_6	1128421.JAGA01000002_gene824	4.022e-76	265.0	COG2264@1|root,COG2264@2|Bacteria,2NPP7@2323|unclassified Bacteria	2|Bacteria	J	Ribosomal protein L11 methyltransferase	prmA	-	-	ko:K02687	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PrmA
REGS1_k127_3095023_0	330214.NIDE2031	9.481e-153	487.0	COG1980@1|root,COG1980@2|Bacteria	2|Bacteria	G	fructose-bisphosphate aldolase activity	fbp	-	3.1.3.11,4.1.2.13	ko:K01622	ko00010,ko00030,ko00051,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00003	R00762,R01068,R01070,R02568,R04780	RC00017,RC00438,RC00439	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_3
REGS1_k127_3116143_0	767817.Desgi_3960	1.602e-204	645.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,260S3@186807|Peptococcaceae	186801|Clostridia	C	Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
REGS1_k127_3116143_1	767817.Desgi_3961	1.096e-108	367.0	COG1251@1|root,COG1251@2|Bacteria,1TQYX@1239|Firmicutes,24AD5@186801|Clostridia,2612C@186807|Peptococcaceae	1239|Firmicutes	C	Pyridine nucleotide-disulphide oxidoreductase	nirB	-	1.6.3.4,1.7.1.15	ko:K00362,ko:K22405	ko00910,ko01120,map00910,map01120	M00530	R00787	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Pyr_redox_2
REGS1_k127_3116585_2	886293.Sinac_5932	4.596e-13	80.0	2BDT3@1|root,327GV@2|Bacteria,2IZW4@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_3116585_0	1382306.JNIM01000001_gene4039	5.301e-87	297.0	COG0109@1|root,COG1612@1|root,COG0109@2|Bacteria,COG1612@2|Bacteria,2G5UC@200795|Chloroflexi	200795|Chloroflexi	H	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	ctaB	GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	COX15-CtaA,UbiA
REGS1_k127_3116585_1	1382306.JNIM01000001_gene4039	1.89e-42	167.0	COG0109@1|root,COG1612@1|root,COG0109@2|Bacteria,COG1612@2|Bacteria,2G5UC@200795|Chloroflexi	200795|Chloroflexi	H	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	ctaB	GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	COX15-CtaA,UbiA
REGS1_k127_3118421_0	525904.Tter_0465	7.522e-89	306.0	COG1482@1|root,COG1482@2|Bacteria,2NR16@2323|unclassified Bacteria	2|Bacteria	G	Phosphomannose isomerase type I	-	-	5.3.1.8	ko:K01809	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01819	RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	PMI_typeI
REGS1_k127_3118421_1	383372.Rcas_4185	1.333e-21	99.0	2ED7R@1|root,3374C@2|Bacteria,2GAGN@200795|Chloroflexi,3761Y@32061|Chloroflexia	32061|Chloroflexia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_3118421_2	926550.CLDAP_07940	1.577e-17	88.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	ko:K14340	-	-	-	-	ko00000,ko01000,ko01003	-	-	-	PMT_2
REGS1_k127_3147385_1	1150399.AQYK01000001_gene295	1.607e-40	154.0	COG3832@1|root,COG3832@2|Bacteria,2IKRU@201174|Actinobacteria	201174|Actinobacteria	S	Activator of hsp90 atpase 1 family protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
REGS1_k127_3147385_0	926569.ANT_08060	2.364e-96	326.0	COG0449@1|root,COG0449@2|Bacteria,2G5V6@200795|Chloroflexi	200795|Chloroflexi	M	PFAM sugar isomerase (SIS)	-	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	SIS
REGS1_k127_3170945_2	1352941.M877_21770	1.194e-27	115.0	COG3824@1|root,COG3824@2|Bacteria,2IKXW@201174|Actinobacteria	201174|Actinobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	Zincin_1
REGS1_k127_3170945_3	1382356.JQMP01000001_gene1018	8.095e-16	92.0	COG3420@1|root,COG3420@2|Bacteria,2GBD6@200795|Chloroflexi,27YVB@189775|Thermomicrobia	189775|Thermomicrobia	P	Periplasmic copper-binding protein (NosD)	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix
REGS1_k127_3170945_4	395493.BegalDRAFT_2260	2.482e-06	61.0	COG1361@1|root,COG2373@1|root,COG4932@1|root,COG1361@2|Bacteria,COG2373@2|Bacteria,COG4932@2|Bacteria,1QUEG@1224|Proteobacteria	1224|Proteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	-	-	3.4.24.40	ko:K01406	ko01503,map01503	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Cadherin,Cadherin_3,Calx-beta,FecR,PKD,SdrD_B,TGFb_propeptide
REGS1_k127_3170945_0	316274.Haur_2249	5.714e-124	409.0	COG0438@1|root,COG0438@2|Bacteria,2G5KS@200795|Chloroflexi,374UR@32061|Chloroflexia	32061|Chloroflexia	M	PFAM glycosyl transferase group 1	-	-	2.4.1.250	ko:K15521	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_transf_4,Glycos_transf_1
REGS1_k127_3170945_1	926550.CLDAP_37610	3.425e-56	209.0	COG5653@1|root,COG5653@2|Bacteria,2G6Z0@200795|Chloroflexi	200795|Chloroflexi	M	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_6
REGS1_k127_3177065_7	880072.Desac_2017	1.039e-29	125.0	COG0683@1|root,COG0683@2|Bacteria,1MXR4@1224|Proteobacteria,42MXX@68525|delta/epsilon subdivisions,2WKJM@28221|Deltaproteobacteria,2MQZG@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	PFAM Extracellular ligand-binding receptor	livK-1	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	iAF987.Gmet_1823	Peripla_BP_6
REGS1_k127_3177065_4	519989.ECTPHS_02876	1.793e-68	245.0	COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,1RNDV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
REGS1_k127_3177065_5	235909.GK3024	3.887e-67	244.0	COG4177@1|root,COG4177@2|Bacteria,1TPMZ@1239|Firmicutes,4HE1X@91061|Bacilli,1WEEP@129337|Geobacillus	91061|Bacilli	P	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
REGS1_k127_3177065_1	1118054.CAGW01000053_gene1391	3.827e-142	467.0	COG1129@1|root,COG1129@2|Bacteria,1UM5N@1239|Firmicutes	1239|Firmicutes	G	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
REGS1_k127_3177065_3	471854.Dfer_5273	8.635e-93	319.0	COG3214@1|root,COG3214@2|Bacteria,4NGF2@976|Bacteroidetes,47MWM@768503|Cytophagia	976|Bacteroidetes	S	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_42
REGS1_k127_3177065_0	504728.K649_00380	1.057e-163	527.0	COG0665@1|root,COG0665@2|Bacteria,1WI96@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
REGS1_k127_3177065_2	671143.DAMO_2817	2.084e-95	332.0	COG2770@1|root,COG5002@1|root,COG2770@2|Bacteria,COG5002@2|Bacteria,2NR3P@2323|unclassified Bacteria	2|Bacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	cpxA	-	2.7.13.3	ko:K02484,ko:K07640,ko:K07643,ko:K07645,ko:K07649,ko:K19609	ko01503,ko02020,ko02024,map01503,map02020,map02024	M00447,M00451,M00453,M00457,M00721,M00722,M00727,M00728,M00770	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	2CSK_N,CpxA_peri,HAMP,HATPase_c,HK_sensor,HisKA
REGS1_k127_3177065_6	1347087.CBYO010000020_gene2923	2.486e-56	203.0	COG0745@1|root,COG0745@2|Bacteria,1TPQG@1239|Firmicutes,4HA8Q@91061|Bacilli	91061|Bacilli	KT	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	yycF	GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141	-	ko:K07668	ko02020,map02020	M00459	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
REGS1_k127_3177476_1	936596.HMPREF1495_2693	4.796e-53	191.0	COG3608@1|root,COG3608@2|Bacteria,1TRKT@1239|Firmicutes,2492W@186801|Clostridia,1HVKD@1164882|Lachnoanaerobaculum	186801|Clostridia	S	Selenium-dependent molybdenum hydroxylase system protein, YqeB family	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	NTP_transf_3
REGS1_k127_3177476_0	264732.Moth_2003	6.961e-57	216.0	COG0740@1|root,COG2068@1|root,COG0740@2|Bacteria,COG2068@2|Bacteria,1TTYG@1239|Firmicutes,25KEI@186801|Clostridia,42IJF@68295|Thermoanaerobacterales	186801|Clostridia	OU	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	-	-	2.7.7.76	ko:K07141	ko00790,map00790	-	R11582	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
REGS1_k127_3177476_2	1380390.JIAT01000009_gene1870	1.625e-39	161.0	COG5542@1|root,COG5542@2|Bacteria,2HNS4@201174|Actinobacteria,4CPZM@84995|Rubrobacteria	84995|Rubrobacteria	S	Mannosyltransferase (PIG-V)	-	-	-	-	-	-	-	-	-	-	-	-	Mannosyl_trans2
REGS1_k127_3177476_3	357808.RoseRS_4433	5.18e-20	94.0	COG1807@1|root,COG1807@2|Bacteria,2GBE4@200795|Chloroflexi,3773Q@32061|Chloroflexia	32061|Chloroflexia	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_3178221_4	324602.Caur_2899	2.757e-47	173.0	COG0649@1|root,COG0649@2|Bacteria,2G5MM@200795|Chloroflexi,3751Y@32061|Chloroflexia	32061|Chloroflexia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD1	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
REGS1_k127_3178221_1	867845.KI911784_gene2801	6.81e-162	522.0	COG1894@1|root,COG1894@2|Bacteria,2G5W1@200795|Chloroflexi,374WU@32061|Chloroflexia	32061|Chloroflexia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	-	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
REGS1_k127_3178221_0	1128421.JAGA01000002_gene144	1.448e-234	754.0	COG3383@1|root,COG3383@2|Bacteria,2NNQ6@2323|unclassified Bacteria	2|Bacteria	C	Molydopterin dinucleotide binding domain	nuoG	-	1.17.1.9,1.6.5.3	ko:K00123,ko:K00336	ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200	M00144	R00519,R11945	RC00061,RC02796	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Fer4,Fer4_6,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
REGS1_k127_3178221_5	1229172.JQFA01000005_gene217	9.115e-14	76.0	COG1708@1|root,COG1708@2|Bacteria,1G8DN@1117|Cyanobacteria,1HC9X@1150|Oscillatoriales	1117|Cyanobacteria	S	Nucleotidyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2
REGS1_k127_3178221_3	383372.Rcas_3387	2.302e-58	208.0	COG1143@1|root,COG1143@2|Bacteria,2G6P8@200795|Chloroflexi,375CU@32061|Chloroflexia	32061|Chloroflexia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoI	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4
REGS1_k127_3178221_2	1449126.JQKL01000043_gene1900	2.646e-158	522.0	COG0247@1|root,COG0247@2|Bacteria,1TPG1@1239|Firmicutes,24BBE@186801|Clostridia	186801|Clostridia	C	Fe-S oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8,Nitrate_red_gam
REGS1_k127_3235095_2	479434.Sthe_2813	8.776e-44	164.0	COG1319@1|root,COG1319@2|Bacteria,2G7KW@200795|Chloroflexi,27Z00@189775|Thermomicrobia	189775|Thermomicrobia	C	CO dehydrogenase flavoprotein domain protein	-	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
REGS1_k127_3235095_0	293826.Amet_0691	2.972e-119	390.0	COG0388@1|root,COG0388@2|Bacteria,1TQDK@1239|Firmicutes,24AWV@186801|Clostridia,36KEG@31979|Clostridiaceae	186801|Clostridia	S	PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
REGS1_k127_3235095_1	926569.ANT_05660	9.7e-101	339.0	COG0074@1|root,COG0074@2|Bacteria,2G7NQ@200795|Chloroflexi	200795|Chloroflexi	C	CoA-ligase	-	-	-	ko:K02381	-	-	-	-	ko00000	-	-	-	CoA_binding,Ligase_CoA
REGS1_k127_3274904_0	670487.Ocepr_0155	3.122e-86	292.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
REGS1_k127_3295479_2	926550.CLDAP_08840	7.456e-106	362.0	COG1007@1|root,COG1007@2|Bacteria,2G5ZK@200795|Chloroflexi	200795|Chloroflexi	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q5_N,Proton_antipo_M
REGS1_k127_3295479_0	926550.CLDAP_08830	4.594e-137	453.0	COG1008@1|root,COG1008@2|Bacteria,2G5VU@200795|Chloroflexi	200795|Chloroflexi	C	TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M	-	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q5_N,Proton_antipo_M
REGS1_k127_3295479_1	292459.STH2769	1.463e-136	455.0	COG1009@1|root,COG1009@2|Bacteria,1TQW4@1239|Firmicutes,24A16@186801|Clostridia	186801|Clostridia	CP	NADH-Ubiquinone oxidoreductase (complex I), chain 5	ndhF	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_C,Proton_antipo_M,Proton_antipo_N
REGS1_k127_329658_4	1128421.JAGA01000002_gene78	9.861e-31	138.0	COG1928@1|root,COG1928@2|Bacteria	2|Bacteria	O	C-terminal four TMM region of protein-O-mannosyltransferase	-	-	2.4.1.109	ko:K00728	ko00514,ko00515,ko01100,map00514,map00515,map01100	-	R04072,R07620,R11399	RC00005,RC00059,RC00397	ko00000,ko00001,ko01000,ko01003	-	GT39	-	PMT,PMT_2,PMT_4TMC
REGS1_k127_329658_6	765420.OSCT_1546	9.054e-07	60.0	2A449@1|root,30SPB@2|Bacteria,2GBRJ@200795|Chloroflexi,376A0@32061|Chloroflexia	32061|Chloroflexia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_329658_3	373994.Riv7116_6904	2.851e-40	162.0	COG1216@1|root,COG1216@2|Bacteria,1G0PG@1117|Cyanobacteria,1HKY4@1161|Nostocales	1117|Cyanobacteria	M	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
REGS1_k127_329658_5	216432.CA2559_02510	3.981e-14	85.0	COG1807@1|root,COG1807@2|Bacteria,4PKU8@976|Bacteroidetes,1IJF3@117743|Flavobacteriia	976|Bacteroidetes	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_329658_2	589865.DaAHT2_2410	1.187e-46	183.0	COG0535@1|root,COG0535@2|Bacteria,1RADC@1224|Proteobacteria,42RDA@68525|delta/epsilon subdivisions,2WN4I@28221|Deltaproteobacteria,2MM5N@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Iron-sulfur cluster-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_14,Radical_SAM,SPASM
REGS1_k127_329658_0	987059.RBXJA2T_01620	4.991e-81	282.0	COG2304@1|root,COG2304@2|Bacteria,1MXQ7@1224|Proteobacteria,2VHRY@28216|Betaproteobacteria,1KKCR@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Von Willebrand factor type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	BatA,VWA,VWA_2
REGS1_k127_329658_1	1128421.JAGA01000001_gene2337	6.364e-81	273.0	COG0572@1|root,COG0572@2|Bacteria,2NPKT@2323|unclassified Bacteria	2|Bacteria	F	Phosphoribulokinase / Uridine kinase family	udk	GO:0003674,GO:0003824,GO:0004849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009224,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043097,GO:0043174,GO:0043771,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046035,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.7.1.19,2.7.1.48	ko:K00855,ko:K00876	ko00240,ko00710,ko00983,ko01100,ko01120,ko01200,map00240,map00710,map00983,map01100,map01120,map01200	M00165,M00166	R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01523,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	iSBO_1134.SBO_0893	PRK
REGS1_k127_342857_3	748247.AZKH_1489	2.993e-43	166.0	COG1306@1|root,COG1306@2|Bacteria,1MWBY@1224|Proteobacteria,2VPH9@28216|Betaproteobacteria,2KYBV@206389|Rhodocyclales	206389|Rhodocyclales	S	Putative glycosyl hydrolase domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4015
REGS1_k127_342857_2	378806.STAUR_8012	4.149e-90	311.0	COG1718@1|root,COG1718@2|Bacteria,1N7US@1224|Proteobacteria,43BB3@68525|delta/epsilon subdivisions,2X6Q8@28221|Deltaproteobacteria,2YTY8@29|Myxococcales	28221|Deltaproteobacteria	DT	Serine threonine protein kinase involved in cell cycle control	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_342857_4	378806.STAUR_8011	1.983e-41	156.0	2CP0Z@1|root,32SI8@2|Bacteria,1RK5X@1224|Proteobacteria,434SF@68525|delta/epsilon subdivisions,2X904@28221|Deltaproteobacteria,2Z0HI@29|Myxococcales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF3037)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3037
REGS1_k127_342857_6	522306.CAP2UW1_3647	1.443e-15	85.0	COG2839@1|root,COG2839@2|Bacteria,1MZEV@1224|Proteobacteria,2VSG8@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Psort location CytoplasmicMembrane, score	-	-	-	ko:K09793	-	-	-	-	ko00000	-	-	-	DUF456
REGS1_k127_342857_1	357808.RoseRS_0229	3.106e-104	349.0	COG1680@1|root,COG1680@2|Bacteria,2GAPT@200795|Chloroflexi,376ZE@32061|Chloroflexia	32061|Chloroflexia	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
REGS1_k127_342857_5	118166.JH976537_gene4851	1.11e-39	156.0	COG2323@1|root,COG2323@2|Bacteria,1G5E3@1117|Cyanobacteria,1HD86@1150|Oscillatoriales	1117|Cyanobacteria	S	Protein of unknown function (DUF421)	-	-	-	-	-	-	-	-	-	-	-	-	DUF421
REGS1_k127_342857_0	522306.CAP2UW1_3003	4.705e-246	777.0	COG1501@1|root,COG1501@2|Bacteria,1MWNJ@1224|Proteobacteria,2VJYR@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Belongs to the glycosyl hydrolase 31 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF5110,Glyco_hydro_31
REGS1_k127_3463703_4	926550.CLDAP_04560	7.598e-113	375.0	COG0438@1|root,COG0438@2|Bacteria,2G5QJ@200795|Chloroflexi	200795|Chloroflexi	M	PFAM glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
REGS1_k127_3463703_5	479434.Sthe_0904	2.902e-86	299.0	COG0438@1|root,COG0438@2|Bacteria,2G5PS@200795|Chloroflexi,27XVU@189775|Thermomicrobia	189775|Thermomicrobia	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
REGS1_k127_3463703_3	926550.CLDAP_04540	6.928e-134	441.0	COG1086@1|root,COG2148@1|root,COG1086@2|Bacteria,COG2148@2|Bacteria,2G66B@200795|Chloroflexi	200795|Chloroflexi	M	PFAM sugar transferase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf,CoA_binding_3
REGS1_k127_3463703_7	1121123.AUAO01000001_gene1562	1.33e-35	146.0	2D8TI@1|root,32TRX@2|Bacteria,1N5N2@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_3463703_0	1128421.JAGA01000001_gene2344	4.41e-184	595.0	COG4907@1|root,COG4907@2|Bacteria,2NQC3@2323|unclassified Bacteria	2|Bacteria	S	Predicted membrane protein (DUF2207)	yciQ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF2207
REGS1_k127_3463703_1	1128421.JAGA01000001_gene2344	2.351e-140	472.0	COG4907@1|root,COG4907@2|Bacteria,2NQC3@2323|unclassified Bacteria	2|Bacteria	S	Predicted membrane protein (DUF2207)	yciQ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF2207
REGS1_k127_3463703_6	1128421.JAGA01000001_gene2343	4.192e-68	237.0	COG1996@1|root,COG1996@2|Bacteria	2|Bacteria	K	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	DUF4379
REGS1_k127_3463703_8	1128421.JAGA01000001_gene2343	2.637e-32	132.0	COG1996@1|root,COG1996@2|Bacteria	2|Bacteria	K	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	DUF4379
REGS1_k127_3463703_9	1365176.N186_06510	4.026e-10	67.0	arCOG05710@1|root,arCOG05710@2157|Archaea,2XQWV@28889|Crenarchaeota	28889|Crenarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_3463703_2	1128421.JAGA01000001_gene2342	4.624e-136	441.0	COG4260@1|root,COG4260@2|Bacteria	2|Bacteria	N	virion core protein, lumpy skin disease virus	-	-	-	-	-	-	-	-	-	-	-	-	Band_7_1,DZR,HTH_17,zinc_ribbon_2
REGS1_k127_3499500_5	604354.TSIB_1211	9.015e-08	61.0	arCOG09492@1|root,arCOG09492@2157|Archaea,2Y3AH@28890|Euryarchaeota,244X9@183968|Thermococci	183968|Thermococci	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_3499500_4	1168034.FH5T_14775	6.788e-15	81.0	2EFWM@1|root,339NX@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_3499500_3	443143.GM18_1262	1.422e-46	176.0	COG4832@1|root,COG4832@2|Bacteria,1RBGY@1224|Proteobacteria,42VX0@68525|delta/epsilon subdivisions,2WRUN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	GyrI-like small molecule binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GyrI-like
REGS1_k127_3499500_6	1114959.SZMC14600_16841	5.631e-06	55.0	COG0748@1|root,COG0748@2|Bacteria,2IIRT@201174|Actinobacteria,4E4KM@85010|Pseudonocardiales	201174|Actinobacteria	P	F420H(2)-dependent quinone reductase	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red
REGS1_k127_3499500_1	1121468.AUBR01000058_gene879	7.065e-57	205.0	COG1014@1|root,COG1014@2|Bacteria,1UYYG@1239|Firmicutes,24I53@186801|Clostridia,42GAS@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM Pyruvate ketoisovalerate oxidoreductase	-	-	1.2.7.3	ko:K00177	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
REGS1_k127_3499500_0	1382306.JNIM01000001_gene1045	1.467e-74	256.0	COG2197@1|root,COG2197@2|Bacteria,2G6PA@200795|Chloroflexi	200795|Chloroflexi	K	Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
REGS1_k127_3499500_2	926550.CLDAP_25550	3.777e-49	188.0	COG2203@1|root,COG4585@1|root,COG5002@1|root,COG2203@2|Bacteria,COG4585@2|Bacteria,COG5002@2|Bacteria,2G8PE@200795|Chloroflexi	200795|Chloroflexi	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
REGS1_k127_350066_5	926550.CLDAP_23390	1.961e-34	147.0	COG1807@1|root,COG1807@2|Bacteria,2G9BJ@200795|Chloroflexi	2|Bacteria	M	Protein of unknown function (DUF2723)	-	-	-	ko:K14340	-	-	-	-	ko00000,ko01000,ko01003	-	-	-	PMT_2
REGS1_k127_350066_6	646529.Desaci_0378	2.944e-33	133.0	COG2050@1|root,COG2050@2|Bacteria,1V824@1239|Firmicutes,24HWD@186801|Clostridia,2670X@186807|Peptococcaceae	186801|Clostridia	Q	PFAM thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
REGS1_k127_350066_7	926550.CLDAP_08050	4.047e-19	97.0	2EHA5@1|root,33B21@2|Bacteria,2G7H6@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	NERD
REGS1_k127_350066_1	525904.Tter_1358	5.52e-135	443.0	COG0304@1|root,COG0304@2|Bacteria,2NNSX@2323|unclassified Bacteria	2|Bacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	-	2.3.1.179,2.3.1.41	ko:K00647,ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
REGS1_k127_350066_2	485913.Krac_8684	1.187e-102	344.0	COG0416@1|root,COG0416@2|Bacteria,2G5Z8@200795|Chloroflexi	200795|Chloroflexi	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA	plsX	-	2.3.1.15	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_synthesis
REGS1_k127_350066_3	41431.PCC8801_0885	3.552e-88	301.0	COG0524@1|root,COG0524@2|Bacteria	2|Bacteria	G	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway	-	-	2.1.1.72,2.7.1.15,2.7.1.4	ko:K00571,ko:K00847,ko:K00852	ko00030,ko00051,ko00500,ko00520,ko01100,map00030,map00051,map00500,map00520,map01100	-	R00760,R00867,R01051,R02750,R03920	RC00002,RC00017	ko00000,ko00001,ko01000,ko02048	-	-	-	PfkB
REGS1_k127_350066_0	635013.TherJR_0057	5.406e-182	583.0	COG5598@1|root,COG5598@2|Bacteria,1V08E@1239|Firmicutes,24BDE@186801|Clostridia,263XC@186807|Peptococcaceae	186801|Clostridia	H	Trimethylamine methyltransferase	-	-	2.1.1.250	ko:K14083	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09124,R10016	RC00035,RC00732,RC01144,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	MTTB
REGS1_k127_3500875_0	886293.Sinac_6192	9.311e-173	554.0	COG0366@1|root,COG3280@1|root,COG0366@2|Bacteria,COG3280@2|Bacteria,2IXJN@203682|Planctomycetes	203682|Planctomycetes	G	alpha amylase catalytic	-	-	3.2.1.133,3.2.1.135,3.2.1.54	ko:K01208	ko00500,ko01100,map00500,map01100	-	R02112,R03122,R11262	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase
REGS1_k127_3500875_1	1125863.JAFN01000001_gene3052	0.0001455	52.0	COG1413@1|root,COG1413@2|Bacteria,1P4H5@1224|Proteobacteria,42WD8@68525|delta/epsilon subdivisions,2WRJT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	HEAT repeat	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
REGS1_k127_3510741_0	234267.Acid_6996	5e-324	1005.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1146@2|Bacteria,3Y415@57723|Acidobacteria	57723|Acidobacteria	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	-	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C
REGS1_k127_3510741_1	926550.CLDAP_36880	4.076e-127	414.0	COG0167@1|root,COG0167@2|Bacteria,2G5T6@200795|Chloroflexi	200795|Chloroflexi	F	Catalyzes the conversion of dihydroorotate to orotate	-	-	1.3.98.1	ko:K00226	ko00240,ko01100,map00240,map01100	M00051	R01867	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
REGS1_k127_3514292_0	926550.CLDAP_39620	5.14e-135	440.0	COG0232@1|root,COG0232@2|Bacteria,2G5VZ@200795|Chloroflexi	200795|Chloroflexi	F	PFAM metal-dependent phosphohydrolase, HD sub domain	dgt	-	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	-	HD,HD_assoc
REGS1_k127_3514292_1	479434.Sthe_0586	4.228e-35	141.0	COG3266@1|root,COG3266@2|Bacteria,2GBHM@200795|Chloroflexi,27Y68@189775|Thermomicrobia	189775|Thermomicrobia	S	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix
REGS1_k127_3540448_0	742767.HMPREF9456_00882	0.0009566	52.0	COG2234@1|root,COG2234@2|Bacteria,4NFDJ@976|Bacteroidetes,2FQ2M@200643|Bacteroidia,22XAT@171551|Porphyromonadaceae	976|Bacteroidetes	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
REGS1_k127_3549521_0	2002.JOEQ01000041_gene6030	1.166e-29	126.0	COG1595@1|root,COG1595@2|Bacteria,2HGII@201174|Actinobacteria,4EIX7@85012|Streptosporangiales	201174|Actinobacteria	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
REGS1_k127_3549521_1	1150864.MILUP08_43876	2.683e-05	55.0	2E1T4@1|root,32X2Z@2|Bacteria,2H4V9@201174|Actinobacteria,4DE78@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_3549851_1	1144275.COCOR_07977	1.178e-19	102.0	COG1807@1|root,COG1807@2|Bacteria,1Q3DA@1224|Proteobacteria,4394U@68525|delta/epsilon subdivisions,2X4B1@28221|Deltaproteobacteria,2YYNE@29|Myxococcales	28221|Deltaproteobacteria	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_3549851_0	311424.DhcVS_182	2.731e-163	530.0	COG0495@1|root,COG0495@2|Bacteria,2G5MX@200795|Chloroflexi,34CK0@301297|Dehalococcoidia	301297|Dehalococcoidia	J	leucyl-tRNA aminoacylation	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1
REGS1_k127_3552137_2	926550.CLDAP_06970	5.238e-114	374.0	COG0589@1|root,COG1215@1|root,COG0589@2|Bacteria,COG1215@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	gpgS	-	2.4.1.266,2.4.1.268	ko:K09118,ko:K13693,ko:K21349	-	-	-	-	ko00000,ko01000,ko01003	-	GT81	-	Glycos_transf_2,Usp
REGS1_k127_3552137_3	926569.ANT_13260	6.439e-111	374.0	COG0391@1|root,COG0391@2|Bacteria,2G5MJ@200795|Chloroflexi	200795|Chloroflexi	S	Required for morphogenesis under gluconeogenic growth conditions	-	-	-	-	-	-	-	-	-	-	-	-	UPF0052
REGS1_k127_3552137_1	479434.Sthe_1253	3.088e-149	479.0	COG0057@1|root,COG0057@2|Bacteria,2G5MG@200795|Chloroflexi,27Y38@189775|Thermomicrobia	189775|Thermomicrobia	C	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	-	-	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
REGS1_k127_3552137_0	661478.OP10G_4138	2.159e-152	493.0	COG0126@1|root,COG0126@2|Bacteria	2|Bacteria	F	phosphoglycerate kinase activity	pgk	GO:0003674,GO:0003824,GO:0004618,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	2.7.2.3,5.3.1.1	ko:K00927,ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01015,R01512	RC00002,RC00043,RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iSbBS512_1146.SbBS512_E3351	PGK
REGS1_k127_3592767_5	1499967.BAYZ01000068_gene1934	4.971e-10	62.0	COG5434@1|root,COG5434@2|Bacteria	2|Bacteria	M	polygalacturonase activity	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,F5_F8_type_C,Glyco_hydro_28,Pectate_lyase_3,SdiA-regulated
REGS1_k127_3592767_1	204669.Acid345_3128	1.077e-70	258.0	COG1287@1|root,COG1287@2|Bacteria,3Y5FJ@57723|Acidobacteria,2JJV3@204432|Acidobacteriia	204432|Acidobacteriia	S	oligosaccharyl transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_3592767_2	204669.Acid345_3128	4.328e-70	257.0	COG1287@1|root,COG1287@2|Bacteria,3Y5FJ@57723|Acidobacteria,2JJV3@204432|Acidobacteriia	204432|Acidobacteriia	S	oligosaccharyl transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_3592767_4	525904.Tter_0233	2.978e-65	233.0	COG2227@1|root,COG2227@2|Bacteria,2NQ8I@2323|unclassified Bacteria	2|Bacteria	H	Methyltransferase domain	-	-	2.1.1.222,2.1.1.64	ko:K00568	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31
REGS1_k127_3592767_3	485913.Krac_11684	3.296e-68	239.0	COG1216@1|root,COG1216@2|Bacteria,2G69V@200795|Chloroflexi	200795|Chloroflexi	S	PFAM Glycosyl transferase family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
REGS1_k127_3592767_0	1396141.BATP01000003_gene5074	5.654e-139	456.0	COG1236@1|root,COG1236@2|Bacteria,46UFS@74201|Verrucomicrobia,2ITNR@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	Beta-Casp domain	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,Lactamase_B_6,RMMBL
REGS1_k127_3592767_6	926550.CLDAP_22700	0.0003061	52.0	COG3103@1|root,COG4991@2|Bacteria	2|Bacteria	T	sh3 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin-like,Glucosaminidase,LysM,SH3_3,TIG
REGS1_k127_3632356_3	196162.Noca_1631	1.429e-09	59.0	COG0540@1|root,COG0540@2|Bacteria,2GKNA@201174|Actinobacteria,4DV65@85009|Propionibacteriales	201174|Actinobacteria	F	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain	pyrB	-	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
REGS1_k127_3632356_0	926569.ANT_01240	1.011e-177	564.0	COG0624@1|root,COG0624@2|Bacteria,2G8AH@200795|Chloroflexi	200795|Chloroflexi	E	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
REGS1_k127_3632356_2	926560.KE387027_gene519	1.163e-63	224.0	COG2045@1|root,COG2045@2|Bacteria,1WMIA@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	H	2-phosphosulpholactate phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	2-ph_phosp
REGS1_k127_3632356_1	485913.Krac_4895	1.365e-67	238.0	COG0477@1|root,COG2814@2|Bacteria,2G8CV@200795|Chloroflexi	2|Bacteria	EGP	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
REGS1_k127_3640905_0	1128421.JAGA01000002_gene1768	1.896e-66	231.0	COG0508@1|root,COG0508@2|Bacteria,2NNZ8@2323|unclassified Bacteria	2|Bacteria	C	e3 binding domain	bfmBB	-	2.3.1.168,2.3.1.61	ko:K00658,ko:K09699	ko00020,ko00280,ko00310,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00280,map00310,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032,M00036	R02570,R02571,R02662,R03174,R04097,R08549,R10998	RC00004,RC02727,RC02833,RC02870	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
REGS1_k127_3640905_1	926550.CLDAP_05920	7.156e-65	240.0	COG1894@1|root,COG1905@1|root,COG1894@2|Bacteria,COG1905@2|Bacteria,2G5W1@200795|Chloroflexi	200795|Chloroflexi	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	-	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
REGS1_k127_3644320_1	926550.CLDAP_19780	3.093e-140	452.0	COG0685@1|root,COG0685@2|Bacteria,2G7NU@200795|Chloroflexi	200795|Chloroflexi	C	PFAM Methylenetetrahydrofolate reductase	-	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
REGS1_k127_3644320_3	926550.CLDAP_19770	5.904e-44	163.0	COG0685@1|root,COG0685@2|Bacteria	2|Bacteria	E	methylenetetrahydrofolate reductase (NAD(P)H) activity	-	-	1.5.1.20,2.1.1.10	ko:K00297,ko:K00547	ko00270,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01523,map00270,map00670,map00720,map01100,map01110,map01120,map01200,map01523	M00377	R00650,R01224,R07168	RC00003,RC00035,RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR,MTHFR_C
REGS1_k127_3644320_2	1122609.AUGT01000020_gene1017	1.063e-83	287.0	COG5012@1|root,COG5012@2|Bacteria,2IEGQ@201174|Actinobacteria,4DTAH@85009|Propionibacteriales	201174|Actinobacteria	S	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,B12-binding_2
REGS1_k127_3644320_0	345341.KUTG_02723	1.445e-215	697.0	COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,2GNCW@201174|Actinobacteria,4E8J5@85010|Pseudonocardiales	201174|Actinobacteria	E	FAD dependent oxidoreductase central domain	-	-	1.5.3.19	ko:K19191	ko00760,ko01120,map00760,map01120	-	R10102	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO,FAO_M,GCV_T,GCV_T_C
REGS1_k127_3696890_0	864702.OsccyDRAFT_4744	0.0	1232.0	COG1452@1|root,COG1452@2|Bacteria,1G0TW@1117|Cyanobacteria,1H7RX@1150|Oscillatoriales	1117|Cyanobacteria	M	Mannosyl oligosaccharide glucosidase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_63
REGS1_k127_3696890_2	485913.Krac_2547	2.559e-140	456.0	COG0492@1|root,COG0492@2|Bacteria,2G5Z5@200795|Chloroflexi	2|Bacteria	C	FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Glutaredoxin,Pyr_redox_2
REGS1_k127_3696890_10	272134.KB731324_gene917	3.095e-12	73.0	2DDFU@1|root,2ZHX4@2|Bacteria,1GG84@1117|Cyanobacteria,1HGJG@1150|Oscillatoriales	1117|Cyanobacteria	S	Protein of unknown function (DUF2721)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2721
REGS1_k127_3696890_3	65393.PCC7424_4195	7.586e-94	319.0	COG1216@1|root,COG1216@2|Bacteria,1G0PG@1117|Cyanobacteria,3KHCP@43988|Cyanothece	1117|Cyanobacteria	M	Glycosyl transferase family 21	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
REGS1_k127_3696890_1	395961.Cyan7425_4465	7.345e-173	556.0	COG1232@1|root,COG1232@2|Bacteria,1G05M@1117|Cyanobacteria,3KGQ6@43988|Cyanothece	1117|Cyanobacteria	H	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
REGS1_k127_3696890_7	926569.ANT_23510	1.256e-18	94.0	COG1470@1|root,COG1470@2|Bacteria,2G6XR@200795|Chloroflexi	200795|Chloroflexi	S	Protein of unknown function (DUF3048) C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3048,DUF3048_C
REGS1_k127_3696890_8	1229517.AMFD01000027_gene540	2.125e-14	79.0	COG1470@1|root,COG1470@2|Bacteria,1TRGE@1239|Firmicutes,4HBPI@91061|Bacilli	91061|Bacilli	S	Protein of unknown function (DUF3048) C-terminal domain	yerB	-	-	-	-	-	-	-	-	-	-	-	DUF3048,DUF3048_C
REGS1_k127_3696890_6	926569.ANT_02350	1.511e-30	127.0	COG1131@1|root,COG1131@2|Bacteria,2G5RD@200795|Chloroflexi	200795|Chloroflexi	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
REGS1_k127_3696890_13	368408.Tpen_1400	0.0008326	44.0	COG1131@1|root,arCOG00194@2157|Archaea,2XPS7@28889|Crenarchaeota	28889|Crenarchaeota	V	PFAM ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
REGS1_k127_3696890_4	1267535.KB906767_gene4790	5.489e-56	204.0	COG5285@1|root,COG5285@2|Bacteria,3Y7AJ@57723|Acidobacteria	57723|Acidobacteria	Q	Phytanoyl-CoA dioxygenase (PhyH)	-	-	-	-	-	-	-	-	-	-	-	-	PhyH
REGS1_k127_3696890_5	269799.Gmet_0691	2.754e-33	133.0	COG1917@1|root,COG1917@2|Bacteria,1RJX2@1224|Proteobacteria,42TVK@68525|delta/epsilon subdivisions,2WQ2T@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
REGS1_k127_3696890_11	313594.PI23P_00800	5.462e-12	74.0	2E53J@1|root,32ZWN@2|Bacteria,4NNS0@976|Bacteroidetes,1I27E@117743|Flavobacteriia,3VV0B@52959|Polaribacter	976|Bacteroidetes	S	Uncharacterised nucleotidyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_5
REGS1_k127_3696890_12	489825.LYNGBM3L_16680	0.0001398	49.0	COG1216@1|root,COG1216@2|Bacteria,1G3T8@1117|Cyanobacteria,1HA4H@1150|Oscillatoriales	1117|Cyanobacteria	S	Uncharacterised nucleotidyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_5
REGS1_k127_3696890_9	604354.TSIB_1217	3.378e-13	79.0	COG1215@1|root,arCOG01389@2157|Archaea,2XVEG@28890|Euryarchaeota,243B1@183968|Thermococci	183968|Thermococci	M	Glycosyl transferase family 21	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3
REGS1_k127_3703962_1	329726.AM1_0874	5.646e-58	212.0	COG2801@1|root,COG2801@2|Bacteria,1G5GD@1117|Cyanobacteria	1117|Cyanobacteria	L	PFAM Integrase core domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,HTH_Tnp_1,rve
REGS1_k127_3703962_2	313596.RB2501_06145	5.706e-05	49.0	COG2963@1|root,COG2963@2|Bacteria,4NVKT@976|Bacteroidetes,1I4CA@117743|Flavobacteriia	976|Bacteroidetes	L	Transposase	-	-	-	ko:K07483	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
REGS1_k127_3703962_0	481448.Minf_2378	1.988e-81	280.0	COG1633@1|root,COG1814@1|root,COG1633@2|Bacteria,COG1814@2|Bacteria,46WTS@74201|Verrucomicrobia,37G3H@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	S	VIT family	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin,VIT1
REGS1_k127_3709123_1	926550.CLDAP_25450	4.321e-101	341.0	COG1674@1|root,COG1674@2|Bacteria,2G5XC@200795|Chloroflexi	2|Bacteria	D	PFAM cell divisionFtsK SpoIIIE	ftsK	GO:0000003,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0019954,GO:0030436,GO:0031323,GO:0031326,GO:0032502,GO:0043934,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
REGS1_k127_3709123_2	765420.OSCT_0528	1.579e-11	68.0	COG0268@1|root,COG0268@2|Bacteria,2G7AK@200795|Chloroflexi,3761R@32061|Chloroflexia	32061|Chloroflexia	J	ribosomal protein S20	rpsT	-	-	ko:K02968	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S20p
REGS1_k127_3709123_0	926550.CLDAP_01110	1.864e-109	367.0	COG0728@1|root,COG0728@2|Bacteria,2G5MD@200795|Chloroflexi	200795|Chloroflexi	S	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	-	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
REGS1_k127_3709271_3	1448860.BBJO01000006_gene1551	8.302e-27	113.0	COG0436@1|root,arCOG01130@2157|Archaea,2XSVT@28890|Euryarchaeota,23SB8@183963|Halobacteria	183963|Halobacteria	E	COG0436 Aspartate tyrosine aromatic aminotransferase	-	-	-	ko:K10907	-	-	-	-	ko00000,ko01000,ko01007	-	-	-	Aminotran_1_2
REGS1_k127_3709271_1	316274.Haur_4591	1.003e-57	207.0	COG0436@1|root,COG0436@2|Bacteria,2G5MC@200795|Chloroflexi,374TY@32061|Chloroflexia	32061|Chloroflexia	E	aminotransferase class I and II	-	-	-	ko:K10907	-	-	-	-	ko00000,ko01000,ko01007	-	-	-	Aminotran_1_2
REGS1_k127_3709271_0	383372.Rcas_4084	8.852e-105	353.0	COG1209@1|root,COG1209@2|Bacteria,2GBKU@200795|Chloroflexi,3781T@32061|Chloroflexia	32061|Chloroflexia	M	Nucleotidyl transferase	-	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
REGS1_k127_3709271_2	945713.IALB_3166	2.161e-57	207.0	COG0313@1|root,COG0313@2|Bacteria	2|Bacteria	H	rRNA processing	rsmI_1	-	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
REGS1_k127_3709271_4	2903.EOD16466	1.06e-24	119.0	KOG0266@1|root,KOG0266@2759|Eukaryota	2759|Eukaryota	B	WD repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	NACHT,WD40
REGS1_k127_3717084_5	926569.ANT_14390	3.166e-69	239.0	COG0402@1|root,COG0402@2|Bacteria,2G7M9@200795|Chloroflexi	200795|Chloroflexi	F	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
REGS1_k127_3717084_8	756067.MicvaDRAFT_2144	5.203e-34	147.0	2DQ0K@1|root,3348P@2|Bacteria,1GBMD@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_3717084_0	1304874.JAFY01000007_gene2147	1.733e-195	619.0	COG0031@1|root,COG0031@2|Bacteria,3T9XD@508458|Synergistetes	508458|Synergistetes	E	PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit	-	-	-	-	-	-	-	-	-	-	-	-	PALP
REGS1_k127_3717084_2	1167006.UWK_01323	3.966e-148	480.0	COG0498@1|root,COG0498@2|Bacteria,1MUWQ@1224|Proteobacteria,42M1W@68525|delta/epsilon subdivisions,2WK53@28221|Deltaproteobacteria,2MIJV@213118|Desulfobacterales	28221|Deltaproteobacteria	E	TIGRFAM threonine synthase	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
REGS1_k127_3717084_7	373994.Riv7116_6075	1.143e-37	156.0	COG1670@1|root,COG1994@1|root,COG1670@2|Bacteria,COG1994@2|Bacteria,1GFNN@1117|Cyanobacteria,1HSNP@1161|Nostocales	1117|Cyanobacteria	J	PFAM Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
REGS1_k127_3717084_4	266117.Rxyl_2848	1.086e-131	426.0	COG0549@1|root,COG0549@2|Bacteria,2HWQ6@201174|Actinobacteria,4CQAT@84995|Rubrobacteria	84995|Rubrobacteria	E	Amino acid kinase family	-	-	2.7.2.2	ko:K00926	ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200	-	R00150,R01395	RC00002,RC00043,RC02803,RC02804	ko00000,ko00001,ko01000	-	-	-	AA_kinase
REGS1_k127_3717084_6	234267.Acid_7087	1.751e-43	175.0	COG1680@1|root,COG1680@2|Bacteria,3Y6F4@57723|Acidobacteria	57723|Acidobacteria	V	PFAM Beta-lactamase	-	-	3.4.16.4	ko:K18988	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Beta-lactamase,DUF3471
REGS1_k127_3717084_1	926550.CLDAP_10970	3.762e-166	527.0	COG0078@1|root,COG0078@2|Bacteria,2G7QE@200795|Chloroflexi	200795|Chloroflexi	E	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain	-	-	2.1.3.9	ko:K09065	ko00220,ko01100,ko01230,map00220,map01100,map01230	M00845	R07245	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
REGS1_k127_3717084_9	237368.SCABRO_00007	1.785e-33	133.0	COG0399@1|root,COG0399@2|Bacteria,2J1H7@203682|Planctomycetes	203682|Planctomycetes	J	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
REGS1_k127_3717084_3	196162.Noca_1631	1.64e-137	443.0	COG0540@1|root,COG0540@2|Bacteria,2GKNA@201174|Actinobacteria,4DV65@85009|Propionibacteriales	201174|Actinobacteria	F	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain	pyrB	-	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
REGS1_k127_372906_3	643648.Slip_1506	6.693e-42	173.0	COG0463@1|root,COG1807@1|root,COG2246@1|root,COG0463@2|Bacteria,COG1807@2|Bacteria,COG2246@2|Bacteria,1UJJF@1239|Firmicutes,25F4I@186801|Clostridia,42KDN@68298|Syntrophomonadaceae	186801|Clostridia	M	Glycosyltransferases involved in cell wall biogenesis-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,GtrA,PMT_2
REGS1_k127_372906_0	485913.Krac_7104	4.461e-169	544.0	COG1018@1|root,COG1018@2|Bacteria,2G9BE@200795|Chloroflexi	200795|Chloroflexi	C	PFAM oxidoreductase FAD NAD(P)-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_1
REGS1_k127_372906_1	485913.Krac_3440	5.011e-92	311.0	COG1477@1|root,COG1477@2|Bacteria	2|Bacteria	H	protein flavinylation	apbE	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE,DUF2271
REGS1_k127_372906_4	485913.Krac_3441	2.973e-28	121.0	COG3976@1|root,COG3976@2|Bacteria	2|Bacteria	S	FMN binding	-	-	-	-	-	-	-	-	-	-	-	-	FMN_bind
REGS1_k127_372906_2	357808.RoseRS_3747	4.551e-48	175.0	COG1266@1|root,COG1266@2|Bacteria	2|Bacteria	V	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
REGS1_k127_3760906_0	383372.Rcas_0532	4.961e-192	653.0	COG0457@1|root,COG5427@1|root,COG0457@2|Bacteria,COG5427@2|Bacteria,2G5UJ@200795|Chloroflexi,37551@32061|Chloroflexia	32061|Chloroflexia	M	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF2298,PMT_2,TPR_16,TPR_19,TPR_8
REGS1_k127_3776865_3	383372.Rcas_2874	1.017e-40	160.0	COG3210@1|root,COG3210@2|Bacteria,2G8VW@200795|Chloroflexi,377DU@32061|Chloroflexia	2|Bacteria	M	TIGRFAM polymorphic outer membrane protein	-	-	-	ko:K21449	-	-	-	-	ko00000,ko02000	1.B.40.2	-	-	Beta_helix,Peptidase_S74
REGS1_k127_3776865_0	926569.ANT_09840	3.386e-89	302.0	COG0005@1|root,COG0005@2|Bacteria,2G5KQ@200795|Chloroflexi	200795|Chloroflexi	F	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate	punA	-	2.4.2.1	ko:K03783	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244	RC00033,RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
REGS1_k127_3776865_2	926569.ANT_22770	7.847e-51	189.0	COG3428@1|root,COG3428@2|Bacteria,2G70V@200795|Chloroflexi	200795|Chloroflexi	S	PFAM membrane-flanked domain	-	-	-	-	-	-	-	-	-	-	-	-	SHOCT,bPH_2
REGS1_k127_3776865_1	357808.RoseRS_0863	3.383e-66	237.0	COG4974@1|root,COG4974@2|Bacteria,2G6CI@200795|Chloroflexi,3754J@32061|Chloroflexia	32061|Chloroflexia	L	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids	xerC	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
REGS1_k127_392465_0	926569.ANT_18510	3.683e-148	485.0	COG2986@1|root,COG2986@2|Bacteria,2G66R@200795|Chloroflexi	200795|Chloroflexi	E	PFAM phenylalanine histidine ammonia-lyase	hutH	-	4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
REGS1_k127_392465_2	935836.JAEL01000201_gene4586	3.666e-05	47.0	2AWWM@1|root,31NU5@2|Bacteria,1TZQ8@1239|Firmicutes,4II4F@91061|Bacilli,1ZJ4J@1386|Bacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_392465_1	258533.BN977_00277	1.231e-39	165.0	COG3391@1|root,COG3693@1|root,COG4932@1|root,COG3391@2|Bacteria,COG3693@2|Bacteria,COG4932@2|Bacteria,2GK45@201174|Actinobacteria,2366T@1762|Mycobacteriaceae	201174|Actinobacteria	M	40-residue YVTN family beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	Cellulase,Lactonase
REGS1_k127_3930021_0	326427.Cagg_3190	1.765e-212	671.0	COG0364@1|root,COG0364@2|Bacteria,2G5MB@200795|Chloroflexi,374UD@32061|Chloroflexia	32061|Chloroflexia	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	zwf	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
REGS1_k127_3930021_2	240016.ABIZ01000001_gene574	2.504e-56	205.0	COG0406@1|root,COG0406@2|Bacteria,46T4J@74201|Verrucomicrobia,2IV5M@203494|Verrucomicrobiae	203494|Verrucomicrobiae	G	Phosphoglycerate mutase family	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
REGS1_k127_3930021_1	1382306.JNIM01000001_gene766	7.736e-161	525.0	COG0166@1|root,COG0166@2|Bacteria,2G67J@200795|Chloroflexi	200795|Chloroflexi	G	Belongs to the GPI family	pgi	-	2.2.1.2,5.3.1.9	ko:K01810,ko:K13810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00004,M00007,M00114	R01827,R02739,R02740,R03321	RC00376,RC00439,RC00563,RC00604	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI,TAL_FSA
REGS1_k127_3932323_2	1123023.JIAI01000006_gene342	1.951e-73	258.0	COG0624@1|root,COG0624@2|Bacteria	2|Bacteria	E	succinyl-diaminopimelate desuccinylase activity	-	-	-	-	-	-	-	-	-	-	-	-	Dala_Dala_lig_C,M20_dimer,Peptidase_M20
REGS1_k127_3932323_1	1128421.JAGA01000001_gene2169	6.63e-86	293.0	COG1526@1|root,COG1526@2|Bacteria,2NPF9@2323|unclassified Bacteria	2|Bacteria	C	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH	fdhD	-	-	ko:K02379	-	-	-	-	ko00000	-	-	-	FdhD-NarQ,NTP_transf_3
REGS1_k127_3932323_0	246194.CHY_2199	2.488e-115	383.0	COG1104@1|root,COG1104@2|Bacteria,1TP21@1239|Firmicutes,24888@186801|Clostridia,42FGX@68295|Thermoanaerobacterales	186801|Clostridia	H	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
REGS1_k127_3932323_3	234267.Acid_3219	2.602e-61	236.0	COG4447@1|root,COG4447@2|Bacteria,3Y4R8@57723|Acidobacteria	57723|Acidobacteria	O	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_3940134_0	926569.ANT_16170	6.663e-159	506.0	COG0499@1|root,COG0499@2|Bacteria,2G5X8@200795|Chloroflexi	200795|Chloroflexi	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
REGS1_k127_3940134_1	926569.ANT_16180	5.172e-112	369.0	COG0524@1|root,COG0524@2|Bacteria,2G7YR@200795|Chloroflexi	200795|Chloroflexi	G	PFAM PfkB domain protein	adoK	-	2.7.1.20	ko:K00856	ko00230,ko01100,map00230,map01100	-	R00185	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
REGS1_k127_3940134_2	1121413.JMKT01000010_gene779	2.003e-06	55.0	2FFD8@1|root,347AV@2|Bacteria,1P29K@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_3978154_14	357808.RoseRS_1915	5.179e-31	138.0	COG0823@1|root,COG0823@2|Bacteria,2G8PZ@200795|Chloroflexi,377MH@32061|Chloroflexia	32061|Chloroflexia	U	WD40 domain protein beta Propeller	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40
REGS1_k127_3978154_20	1382306.JNIM01000001_gene1584	1.793e-12	72.0	COG3629@1|root,COG3899@1|root,COG3629@2|Bacteria,COG3899@2|Bacteria,2G871@200795|Chloroflexi	200795|Chloroflexi	K	Transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD,TPR_12
REGS1_k127_3978154_12	1121918.ARWE01000001_gene306	1.785e-55	200.0	COG1896@1|root,COG1896@2|Bacteria,1R71H@1224|Proteobacteria,42NGN@68525|delta/epsilon subdivisions,2WKMF@28221|Deltaproteobacteria,43S2K@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	HD domain	-	-	-	ko:K07023	-	-	-	-	ko00000	-	-	-	HD_3
REGS1_k127_3978154_9	264732.Moth_1560	7.211e-70	243.0	COG2231@1|root,COG2231@2|Bacteria,1V4SG@1239|Firmicutes,24G98@186801|Clostridia,42G1N@68295|Thermoanaerobacterales	186801|Clostridia	L	PFAM HhH-GPD family protein	-	-	-	ko:K07457	-	-	-	-	ko00000	-	-	-	HhH-GPD
REGS1_k127_3978154_21	429009.Adeg_2152	2.421e-11	65.0	COG0230@1|root,COG0230@2|Bacteria,1VK90@1239|Firmicutes,24UGN@186801|Clostridia,42HF3@68295|Thermoanaerobacterales	186801|Clostridia	J	Belongs to the bacterial ribosomal protein bL34 family	rpmH	-	-	ko:K02914	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L34
REGS1_k127_3978154_18	357808.RoseRS_3966	9.93e-23	101.0	COG0594@1|root,COG0594@2|Bacteria,2G76W@200795|Chloroflexi,375ZH@32061|Chloroflexia	32061|Chloroflexia	J	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme	rnpA	-	3.1.26.5	ko:K03536	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_P
REGS1_k127_3978154_15	533247.CRD_01802	1.785e-27	112.0	COG0759@1|root,COG0759@2|Bacteria,1G90B@1117|Cyanobacteria,1HPBQ@1161|Nostocales	1117|Cyanobacteria	S	Could be involved in insertion of integral membrane proteins into the membrane	-	-	-	ko:K08998	-	-	-	-	ko00000	-	-	-	Haemolytic
REGS1_k127_3978154_11	1123320.KB889731_gene6103	1.174e-65	237.0	COG0515@1|root,COG1520@1|root,COG0515@2|Bacteria,COG1520@2|Bacteria,2IAZ2@201174|Actinobacteria	201174|Actinobacteria	KLT	PQQ enzyme repeat	-	-	1.1.2.6,2.7.11.1	ko:K05889,ko:K12132	-	-	R03136	-	ko00000,ko01000,ko01001	-	-	-	PQQ,PQQ_2,PQQ_3,Pkinase
REGS1_k127_3978154_16	498761.HM1_0910	2.212e-26	119.0	COG0706@1|root,COG0706@2|Bacteria,1TQ0J@1239|Firmicutes,247V9@186801|Clostridia	186801|Clostridia	U	Membrane protein insertase, YidC Oxa1 family	oxaA	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP
REGS1_k127_3978154_13	926569.ANT_22890	4.989e-34	140.0	COG1847@1|root,COG1847@2|Bacteria,2G6XH@200795|Chloroflexi	200795|Chloroflexi	S	PFAM single-stranded nucleic acid binding R3H domain protein	-	-	-	ko:K06346	-	-	-	-	ko00000	-	-	-	Jag_N,KH_4,R3H
REGS1_k127_3978154_10	1382306.JNIM01000001_gene4052	4.66e-68	242.0	COG0524@1|root,COG0524@2|Bacteria,2G6PQ@200795|Chloroflexi	200795|Chloroflexi	G	PFAM PfkB domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
REGS1_k127_3978154_6	203119.Cthe_2377	1.441e-86	293.0	COG1192@1|root,COG1192@2|Bacteria,1TP8S@1239|Firmicutes,2488C@186801|Clostridia,3WGTZ@541000|Ruminococcaceae	186801|Clostridia	D	CobQ CobB MinD ParA nucleotide binding domain	soj	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
REGS1_k127_3978154_8	479434.Sthe_0467	2.025e-80	277.0	COG1475@1|root,COG1475@2|Bacteria,2G6EK@200795|Chloroflexi,27XFW@189775|Thermomicrobia	189775|Thermomicrobia	K	ParB-like nuclease domain	-	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
REGS1_k127_3978154_2	926550.CLDAP_23640	1.785e-137	445.0	COG1239@1|root,COG1239@2|Bacteria,2G5WJ@200795|Chloroflexi	200795|Chloroflexi	H	introduces a magnesium ion into protoporphyrin IX to yield Mg-protoporphyrin IX	-	-	6.6.1.1	ko:K03404,ko:K03405	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03877	RC01012	ko00000,ko00001,ko01000	-	-	-	AAA_5,Mg_chelatase,VWA_2
REGS1_k127_3978154_5	926569.ANT_05390	6.473e-97	327.0	COG1240@1|root,COG1240@2|Bacteria,2G7UF@200795|Chloroflexi	200795|Chloroflexi	H	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA_2
REGS1_k127_3978154_1	1128421.JAGA01000003_gene3665	5.724e-140	454.0	COG2129@1|root,COG2129@2|Bacteria	2|Bacteria	L	metallophosphoesterase	-	-	-	ko:K07096,ko:K07496	-	-	-	-	ko00000	-	-	-	Metallophos,Metallophos_2,Metallophos_3
REGS1_k127_3978154_0	1128421.JAGA01000003_gene3664	1.168e-247	776.0	COG0531@1|root,COG0531@2|Bacteria	2|Bacteria	E	amino acid	steT	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease,AA_permease_2
REGS1_k127_3978154_7	1128421.JAGA01000003_gene3663	6.672e-82	279.0	arCOG06048@1|root,31EJQ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_3978154_3	525904.Tter_0993	3.803e-122	404.0	COG0592@1|root,COG0592@2|Bacteria,2NP7D@2323|unclassified Bacteria	2|Bacteria	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	dnaN	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
REGS1_k127_3978154_17	65393.PCC7424_5052	2.177e-25	108.0	COG2929@1|root,COG2929@2|Bacteria,1G92M@1117|Cyanobacteria	1117|Cyanobacteria	S	COGs COG2929 conserved	-	-	-	ko:K09803	-	-	-	-	ko00000	-	-	-	BrnT_toxin
REGS1_k127_3978154_19	555779.Dthio_PD2839	3.44e-20	93.0	2C6B2@1|root,335GA@2|Bacteria,1NG8G@1224|Proteobacteria,42X8T@68525|delta/epsilon subdivisions,2WSSY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_3978154_4	255470.cbdbA939	9.1e-117	389.0	COG0104@1|root,COG0104@2|Bacteria,2G602@200795|Chloroflexi,34D3D@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
REGS1_k127_3978154_22	713587.THITH_08815	5.694e-10	61.0	COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,1RN93@1236|Gammaproteobacteria,1WW57@135613|Chromatiales	135613|Chromatiales	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	-	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ASL_C,Lyase_1
REGS1_k127_3999915_2	1121091.AUMP01000003_gene2899	2.118e-13	73.0	COG1205@1|root,COG1205@2|Bacteria,1TSPA@1239|Firmicutes,4H9T2@91061|Bacilli	91061|Bacilli	L	COG1205 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster	yprA	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360	-	ko:K06877	-	-	-	-	ko00000	-	-	-	DEAD,DUF1998,Helicase_C
REGS1_k127_3999915_3	1996.JOFO01000032_gene1309	4.351e-08	60.0	2DS6Y@1|root,33EU1@2|Bacteria,2I89N@201174|Actinobacteria	201174|Actinobacteria	S	Sporulation protein YtfJ (Spore_YtfJ)	-	-	-	-	-	-	-	-	-	-	-	-	Spore_YtfJ
REGS1_k127_3999915_0	926550.CLDAP_05510	2.333e-122	399.0	COG1215@1|root,COG1215@2|Bacteria,2G8CP@200795|Chloroflexi	200795|Chloroflexi	M	Glycosyl transferase family group 2	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_3999915_1	926550.CLDAP_05520	5.152e-16	85.0	COG0392@1|root,COG0392@2|Bacteria	2|Bacteria	M	lysyltransferase activity	mprF	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
REGS1_k127_4039142_0	525904.Tter_2859	9.226e-150	496.0	COG3629@1|root,COG3903@1|root,COG3629@2|Bacteria,COG3903@2|Bacteria,2NQCZ@2323|unclassified Bacteria	2|Bacteria	K	NB-ARC domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22,BTAD,HTH_31,NB-ARC,Pkinase,TPR_10,TPR_12,Trans_reg_C
REGS1_k127_4039142_1	485913.Krac_10314	1.376e-69	246.0	COG1718@1|root,COG1718@2|Bacteria	2|Bacteria	DT	cellular response to dsDNA	IV02_22125	-	2.7.11.1	ko:K07178	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko01001,ko03009	-	-	-	RIO1
REGS1_k127_4046632_0	926550.CLDAP_31350	6.526e-66	252.0	COG5305@1|root,COG5305@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
REGS1_k127_4054771_2	1247963.JPHU01000002_gene2497	3.017e-09	59.0	COG1216@1|root,COG1216@2|Bacteria,1RHVX@1224|Proteobacteria,2UA24@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Glycosyl transferase family 21	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
REGS1_k127_4054771_3	459349.CLOAM1324	1.12e-06	60.0	COG0392@1|root,COG0392@2|Bacteria,2NPGZ@2323|unclassified Bacteria	2|Bacteria	S	Lysylphosphatidylglycerol synthase TM region	mprF	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
REGS1_k127_4054771_1	1128421.JAGA01000002_gene1893	1.044e-100	344.0	COG0612@1|root,COG0612@2|Bacteria,2NNW3@2323|unclassified Bacteria	2|Bacteria	S	Belongs to the peptidase M16 family	pepR	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
REGS1_k127_4054771_0	1521187.JPIM01000196_gene3600	1.385e-162	519.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	rgpA	-	-	ko:K12996	-	-	-	-	ko00000,ko01000,ko01003,ko01005	-	GT4	-	DUF1972,Glyco_trans_1_4,Glycos_transf_1
REGS1_k127_4056817_8	926569.ANT_05660	7.411e-41	156.0	COG0074@1|root,COG0074@2|Bacteria,2G7NQ@200795|Chloroflexi	200795|Chloroflexi	C	CoA-ligase	-	-	-	ko:K02381	-	-	-	-	ko00000	-	-	-	CoA_binding,Ligase_CoA
REGS1_k127_4056817_12	1196028.ALEF01000015_gene2603	7.374e-10	69.0	2DBAX@1|root,2Z84Q@2|Bacteria,1VHQG@1239|Firmicutes,4HPN3@91061|Bacilli	91061|Bacilli	S	Protein of unknown function (DUF2877)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2877
REGS1_k127_4056817_4	1382356.JQMP01000003_gene1475	2.768e-150	477.0	COG1878@1|root,COG1878@2|Bacteria,2GBDZ@200795|Chloroflexi,27Z1S@189775|Thermomicrobia	189775|Thermomicrobia	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
REGS1_k127_4056817_2	926569.ANT_05670	2.832e-182	578.0	COG0074@1|root,COG0074@2|Bacteria,2G7UI@200795|Chloroflexi	200795|Chloroflexi	C	Protein of unknown function (DUF1116)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1116
REGS1_k127_4056817_3	1469607.KK073768_gene3306	6.499e-174	561.0	COG0318@1|root,COG0318@2|Bacteria,1G2H0@1117|Cyanobacteria,1HIDR@1161|Nostocales	1117|Cyanobacteria	IQ	Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II	-	-	6.2.1.3	ko:K00666,ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
REGS1_k127_4056817_10	1202768.JROF01000003_gene3080	7.145e-24	106.0	COG0824@1|root,arCOG01137@2157|Archaea,2XXHC@28890|Euryarchaeota,23VWV@183963|Halobacteria	183963|Halobacteria	S	Thioesterase superfamily	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2
REGS1_k127_4056817_6	1382356.JQMP01000003_gene2070	3.114e-116	380.0	COG1024@1|root,COG1024@2|Bacteria,2G6BP@200795|Chloroflexi,27XR0@189775|Thermomicrobia	189775|Thermomicrobia	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
REGS1_k127_4056817_1	1254432.SCE1572_02095	1.79e-195	628.0	COG1226@1|root,COG1226@2|Bacteria,1MV0T@1224|Proteobacteria,43DUN@68525|delta/epsilon subdivisions,2WYXG@28221|Deltaproteobacteria,2Z0V5@29|Myxococcales	28221|Deltaproteobacteria	P	Castor and Pollux, part of voltage-gated ion channel	-	-	-	-	-	-	-	-	-	-	-	-	Castor_Poll_mid
REGS1_k127_4056817_0	981384.AEYW01000001_gene1562	7.606e-215	723.0	COG0642@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2TX3Q@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HAMP,HATPase_c,HisKA,Hpt,Response_reg,dCache_1
REGS1_k127_4056817_11	880072.Desac_0096	7.055e-14	76.0	COG0642@1|root,COG0745@1|root,COG0784@1|root,COG2198@1|root,COG2202@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2WIR4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,Hpt,PAS_3,PAS_8,PAS_9,Response_reg,SBP_bac_3
REGS1_k127_4056817_5	1118054.CAGW01000081_gene2691	1.364e-126	420.0	COG1679@1|root,COG1786@1|root,COG1679@2|Bacteria,COG1786@2|Bacteria,1UJDG@1239|Firmicutes,4HTS5@91061|Bacilli	91061|Bacilli	S	Protein of unknown function (DUF521)	-	-	-	ko:K09123	-	-	-	-	ko00000	-	-	-	DUF521
REGS1_k127_4056817_9	1156935.QWE_17443	2.318e-33	133.0	COG1679@1|root,COG1786@1|root,COG1679@2|Bacteria,COG1786@2|Bacteria,1NFH4@1224|Proteobacteria,2TTR6@28211|Alphaproteobacteria,4B9RE@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF521)	-	-	-	ko:K09123	-	-	-	-	ko00000	-	-	-	DUF126,DUF521
REGS1_k127_4056817_7	1499967.BAYZ01000019_gene6292	1.961e-70	244.0	COG0673@1|root,COG0673@2|Bacteria,2NQ2X@2323|unclassified Bacteria	2|Bacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	1.1.1.335	ko:K13020	ko00520,map00520	-	R10140	RC00182	ko00000,ko00001,ko01000,ko01005	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
REGS1_k127_4074590_2	926569.ANT_11660	5.628e-29	122.0	COG2246@1|root,COG2246@2|Bacteria,2G7BJ@200795|Chloroflexi	200795|Chloroflexi	S	GtrA-like protein	-	-	-	-	-	-	-	-	-	-	-	-	GtrA
REGS1_k127_4074590_0	926550.CLDAP_33690	3.12e-68	250.0	COG3307@1|root,COG3307@2|Bacteria,2G6TE@200795|Chloroflexi	200795|Chloroflexi	M	PFAM O-antigen polymerase	-	-	-	-	-	-	-	-	-	-	-	-	Wzy_C
REGS1_k127_4074590_1	497964.CfE428DRAFT_4613	3.198e-38	145.0	COG0451@1|root,COG0451@2|Bacteria,46S80@74201|Verrucomicrobia	74201|Verrucomicrobia	GM	GDP-mannose 4,6 dehydratase	-	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
REGS1_k127_4077095_2	926550.CLDAP_26120	1.022e-59	215.0	COG1082@1|root,COG1082@2|Bacteria,2G9NU@200795|Chloroflexi	200795|Chloroflexi	G	PFAM Xylose isomerase domain protein TIM barrel	-	-	5.3.99.11	ko:K06606	ko00562,ko01120,map00562,map01120	-	R09952	RC01513	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
REGS1_k127_4077095_0	1121335.Clst_0987	6.107e-152	490.0	COG1402@1|root,COG1402@2|Bacteria,1V0N8@1239|Firmicutes,24BWG@186801|Clostridia,3WMNU@541000|Ruminococcaceae	186801|Clostridia	S	Creatinine amidohydrolase	-	-	3.5.2.10	ko:K01470,ko:K22232	ko00330,ko00562,map00330,map00562	-	R01884,R11771	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
REGS1_k127_4077095_1	696369.KI912183_gene75	4.635e-78	271.0	COG1082@1|root,COG1082@2|Bacteria,1TRXP@1239|Firmicutes,24EWV@186801|Clostridia,262DG@186807|Peptococcaceae	186801|Clostridia	G	Xylose isomerase-like TIM barrel	-	-	-	ko:K22233	ko00562,map00562	-	R11772	-	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
REGS1_k127_4077095_3	296591.Bpro_0417	6.695e-33	138.0	COG1802@1|root,COG1802@2|Bacteria,1MW9G@1224|Proteobacteria,2VQ9U@28216|Betaproteobacteria,4AIYS@80864|Comamonadaceae	28216|Betaproteobacteria	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
REGS1_k127_4088483_0	926550.CLDAP_05320	1.572e-159	515.0	COG1529@1|root,COG2080@1|root,COG1529@2|Bacteria,COG2080@2|Bacteria,2G65D@200795|Chloroflexi	200795|Chloroflexi	C	aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2,Fer2_2
REGS1_k127_4088483_1	861299.J421_0074	7.929e-33	137.0	COG0708@1|root,COG0708@2|Bacteria	2|Bacteria	L	double-stranded DNA 3'-5' exodeoxyribonuclease activity	-	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
REGS1_k127_410658_1	1379698.RBG1_1C00001G0054	2.484e-146	466.0	COG2502@1|root,COG2502@2|Bacteria,2NNKP@2323|unclassified Bacteria	2|Bacteria	E	Aspartate-ammonia ligase	asnA	GO:0003674,GO:0003824,GO:0004071,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006528,GO:0006529,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009987,GO:0016053,GO:0016211,GO:0016874,GO:0016879,GO:0016880,GO:0019752,GO:0032787,GO:0033554,GO:0034641,GO:0042802,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0050896,GO:0051716,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.1.1	ko:K01914	ko00250,ko00460,ko01100,ko01110,ko01230,map00250,map00460,map01100,map01110,map01230	-	R00483	RC00010	ko00000,ko00001,ko01000	-	-	iAPECO1_1312.APECO1_2719,iECOK1_1307.ECOK1_4193,iECS88_1305.ECS88_4166,iUMN146_1321.UM146_18910,iUTI89_1310.UTI89_C4299	AsnA
REGS1_k127_410658_13	608538.HTH_1380	3.088e-40	167.0	COG3210@1|root,COG3227@1|root,COG3210@2|Bacteria,COG3227@2|Bacteria	2|Bacteria	E	Zinc metalloprotease (Elastase)	-	-	3.2.1.18,3.4.11.10	ko:K01186,ko:K05994,ko:K21449	ko00511,ko00600,ko04142,map00511,map00600,map04142	-	R04018	RC00028,RC00077	ko00000,ko00001,ko01000,ko01002,ko02000,ko02042	1.B.40.2	GH33	-	Beta_helix,PKD,Peptidase_S74,fn3
REGS1_k127_410658_7	1382304.JNIL01000001_gene3204	8.637e-75	258.0	COG2041@1|root,COG2041@2|Bacteria,1V1P9@1239|Firmicutes,4HFQC@91061|Bacilli,278B0@186823|Alicyclobacillaceae	91061|Bacilli	S	Oxidoreductase molybdopterin binding domain	yuiH	-	-	-	-	-	-	-	-	-	-	-	Oxidored_molyb
REGS1_k127_410658_4	316274.Haur_4664	1.482e-87	304.0	COG0642@1|root,COG2205@2|Bacteria,2GBIY@200795|Chloroflexi	200795|Chloroflexi	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
REGS1_k127_410658_5	446470.Snas_0721	3.636e-81	276.0	COG0745@1|root,COG0745@2|Bacteria,2GK5S@201174|Actinobacteria,4EZPK@85014|Glycomycetales	201174|Actinobacteria	T	Transcriptional regulatory protein, C terminal	resD	-	-	ko:K07776	ko02020,map02020	M00443	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
REGS1_k127_410658_3	926569.ANT_16820	1.054e-118	396.0	COG1408@1|root,COG1408@2|Bacteria,2G6VC@200795|Chloroflexi	200795|Chloroflexi	S	PFAM metallophosphoesterase	-	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos
REGS1_k127_410658_17	204669.Acid345_1334	3.024e-15	84.0	COG5295@1|root,COG5295@2|Bacteria,3Y72W@57723|Acidobacteria,2JM9T@204432|Acidobacteriia	2|Bacteria	UW	Hep Hag repeat protein	yeeJ	-	-	ko:K21449	-	-	-	-	ko00000,ko02000	1.B.40.2	-	-	DUF5122,Peptidase_S74,YadA_head,YadA_stalk
REGS1_k127_410658_6	211165.AJLN01000062_gene3868	1.071e-77	266.0	COG2949@1|root,COG2949@2|Bacteria,1G297@1117|Cyanobacteria,1JKYS@1189|Stigonemataceae	1117|Cyanobacteria	S	DUF218 domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF218
REGS1_k127_410658_10	1267534.KB906759_gene1753	1.396e-51	187.0	COG2080@1|root,COG2080@2|Bacteria,3Y4DP@57723|Acidobacteria,2JJ2F@204432|Acidobacteriia	204432|Acidobacteriia	C	2Fe-2S -binding	-	-	-	ko:K13483	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002	-	-	-	Fer2,Fer2_2,TAT_signal
REGS1_k127_410658_0	867903.ThesuDRAFT_01467	4.12e-248	788.0	COG1529@1|root,COG1529@2|Bacteria,1TP7U@1239|Firmicutes,248BV@186801|Clostridia	186801|Clostridia	C	aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	1.17.1.4	ko:K11177	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
REGS1_k127_410658_15	1172181.KB911699_gene1394	1.154e-29	123.0	2BVHN@1|root,32QW3@2|Bacteria,2IKWS@201174|Actinobacteria	201174|Actinobacteria	S	F420H(2)-dependent quinone reductase	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red
REGS1_k127_410658_8	1128421.JAGA01000002_gene261	4.352e-70	248.0	COG1319@1|root,COG1319@2|Bacteria,2NQUQ@2323|unclassified Bacteria	2|Bacteria	C	CO dehydrogenase flavoprotein C-terminal domain	yagS	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016903,GO:0036094,GO:0042597,GO:0043167,GO:0043168,GO:0044464,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0097159,GO:1901265,GO:1901363	1.17.1.4	ko:K11178	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
REGS1_k127_410658_2	316274.Haur_3936	8.681e-123	409.0	COG0477@1|root,COG2223@1|root,COG2223@2|Bacteria,COG2814@2|Bacteria,2GA7I@200795|Chloroflexi,3780K@32061|Chloroflexia	200795|Chloroflexi	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
REGS1_k127_410658_18	937777.Deipe_2178	1.005e-08	66.0	COG0265@1|root,COG0265@2|Bacteria	2|Bacteria	O	serine-type endopeptidase activity	-	-	3.4.21.107	ko:K04771,ko:K08372	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,PG_binding_1,Trypsin_2
REGS1_k127_410658_12	1123371.ATXH01000022_gene964	2.785e-40	156.0	COG0558@1|root,COG0558@2|Bacteria,2GH4T@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
REGS1_k127_410658_16	311424.DhcVS_851	3.018e-26	112.0	COG0438@1|root,COG0438@2|Bacteria,2G61C@200795|Chloroflexi,34CIQ@301297|Dehalococcoidia	301297|Dehalococcoidia	M	Glycosyl transferases group 1	-	-	2.4.1.345	ko:K08256	-	-	R11702	-	ko00000,ko01000,ko01003	-	GT4	-	Glyco_transf_4,Glycos_transf_1
REGS1_k127_410658_9	525904.Tter_1866	1.173e-57	210.0	COG0438@1|root,COG0438@2|Bacteria,2NQ17@2323|unclassified Bacteria	2|Bacteria	M	glycosyl transferase group 1	-	-	2.4.1.345	ko:K08256	-	-	R11702	-	ko00000,ko01000,ko01003	-	GT4	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
REGS1_k127_410658_14	479434.Sthe_1718	2.694e-32	142.0	COG1560@1|root,COG1560@2|Bacteria,2G7BA@200795|Chloroflexi,27Y7M@189775|Thermomicrobia	189775|Thermomicrobia	M	Bacterial lipid A biosynthesis acyltransferase	-	-	2.3.1.241,2.3.1.265	ko:K02517,ko:K22311	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
REGS1_k127_410658_11	272134.KB731324_gene3102	6.149e-48	176.0	COG1515@1|root,COG1515@2|Bacteria,1G2HF@1117|Cyanobacteria,1H8TY@1150|Oscillatoriales	1117|Cyanobacteria	L	DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA	nfi	-	3.1.21.7	ko:K05982	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Endonuclease_5
REGS1_k127_4131371_1	317936.Nos7107_2811	4.227e-07	59.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,1G135@1117|Cyanobacteria,1HMDR@1161|Nostocales	1117|Cyanobacteria	S	PFAM Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,TPR_10,TPR_12,TPR_4,TPR_7
REGS1_k127_4131371_0	309801.trd_0440	3.996e-147	472.0	COG2006@1|root,COG2006@2|Bacteria,2GA2Y@200795|Chloroflexi,27YWH@189775|Thermomicrobia	189775|Thermomicrobia	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
REGS1_k127_4138284_5	634498.mru_2173	1.024e-05	59.0	COG0675@1|root,arCOG01917@1|root,arCOG00679@2157|Archaea,arCOG01917@2157|Archaea	2157|Archaea	M	deoxyhypusine monooxygenase activity	-	-	-	ko:K07496	-	-	-	-	ko00000	-	-	-	OrfB_Zn_ribbon,zinc_ribbon_2
REGS1_k127_4138284_3	330214.NIDE2490	2.323e-26	117.0	29ZH8@1|root,30MGZ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_4138284_2	383372.Rcas_2221	5.106e-35	143.0	28MEN@1|root,2ZASA@2|Bacteria,2G97S@200795|Chloroflexi,375P3@32061|Chloroflexia	32061|Chloroflexia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_4138284_0	1449126.JQKL01000016_gene2859	3.572e-98	328.0	COG2267@1|root,COG2267@2|Bacteria,1TRM1@1239|Firmicutes,247J5@186801|Clostridia	186801|Clostridia	I	Hydrolase, alpha beta domain protein	-	-	3.1.1.5	ko:K01048	ko00564,map00564	-	-	-	ko00000,ko00001,ko01000	-	-	-	Hydrolase_4
REGS1_k127_4138284_1	1521187.JPIM01000060_gene2911	2.936e-79	278.0	COG1744@1|root,COG1744@2|Bacteria,2G6UB@200795|Chloroflexi,375H7@32061|Chloroflexia	32061|Chloroflexia	M	PFAM basic membrane lipoprotein	-	-	-	ko:K07335	-	-	-	-	ko00000	-	-	-	Bmp
REGS1_k127_4156364_9	1304865.JAGF01000001_gene2445	2.603e-27	118.0	COG0697@1|root,COG0697@2|Bacteria,2IH82@201174|Actinobacteria	201174|Actinobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
REGS1_k127_4156364_6	479434.Sthe_2499	5.579e-75	259.0	29JD5@1|root,306AN@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_4156364_14	401526.TcarDRAFT_0343	2.795e-05	50.0	COG0298@1|root,COG0298@2|Bacteria,1VFE0@1239|Firmicutes,4H5P1@909932|Negativicutes	909932|Negativicutes	O	Hydrogenase assembly chaperone hypC hupF	hypC	-	-	ko:K04653	-	-	-	-	ko00000	-	-	-	HupF_HypC
REGS1_k127_4156364_11	926569.ANT_22100	2.145e-25	113.0	COG0839@1|root,COG0839@2|Bacteria	2|Bacteria	C	Belongs to the complex I subunit 6 family	nuoJ	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
REGS1_k127_4156364_12	926569.ANT_22090	1.65e-23	103.0	COG1006@1|root,COG1006@2|Bacteria	2|Bacteria	P	Multisubunit Na H antiporter MnhC subunit	mnhC	-	1.6.5.3	ko:K00340,ko:K05567	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko02000	2.A.63.1,2.A.63.2,3.D.1	-	-	Oxidored_q2
REGS1_k127_4156364_0	926569.ANT_22080	1.041e-208	663.0	COG1009@1|root,COG1009@2|Bacteria,2G5NJ@200795|Chloroflexi	926569.ANT_22080|-	CP	NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_4156364_2	926569.ANT_22070	2.58e-142	469.0	COG0651@1|root,COG0651@2|Bacteria	2|Bacteria	CP	ATP synthesis coupled electron transport	mrpD	-	1.6.5.3	ko:K00342,ko:K00343,ko:K05568	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko02000	2.A.63.1,2.A.63.2,3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
REGS1_k127_4156364_5	926569.ANT_22050	5.258e-76	257.0	COG3260@1|root,COG3260@2|Bacteria,2G8XX@200795|Chloroflexi	200795|Chloroflexi	C	NADH ubiquinone oxidoreductase, 20 Kd subunit	echC	-	-	ko:K14088	-	-	-	-	ko00000	-	-	-	Oxidored_q6
REGS1_k127_4156364_8	926569.ANT_22040	5.956e-36	141.0	COG0852@1|root,COG0852@2|Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00332,ko:K13378	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa,Complex1_49kDa
REGS1_k127_4156364_1	926569.ANT_22030	1.873e-189	598.0	COG3261@1|root,COG3261@2|Bacteria,2G8BA@200795|Chloroflexi	200795|Chloroflexi	C	Respiratory-chain NADH dehydrogenase, 49 Kd subunit	-	-	-	ko:K14090	-	-	-	-	ko00000	-	-	-	Complex1_49kDa,NiFeSe_Hases
REGS1_k127_4156364_3	926569.ANT_22020	1.079e-130	423.0	COG1005@1|root,COG1005@2|Bacteria	2|Bacteria	C	quinone binding	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
REGS1_k127_4156364_7	926569.ANT_22010	1.19e-53	193.0	COG1143@1|root,COG1143@2|Bacteria,2G9SP@200795|Chloroflexi	200795|Chloroflexi	C	4Fe-4S binding domain	-	-	-	ko:K14091	-	-	-	-	ko00000	-	-	-	Fer4
REGS1_k127_4156364_10	926569.ANT_22000	4.737e-26	116.0	COG0680@1|root,COG0680@2|Bacteria	2|Bacteria	C	spore germination	-	-	3.4.23.51	ko:K00442,ko:K08315	ko00680,ko01100,ko01120,map00680,map01100,map01120	-	R03025	RC02628	ko00000,ko00001,ko01000,ko01002	-	-	-	HycI
REGS1_k127_4156364_4	526227.Mesil_2532	1.745e-100	343.0	COG0747@1|root,COG0747@2|Bacteria,1WI92@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
REGS1_k127_4178977_0	909663.KI867150_gene2380	9.999e-97	327.0	COG3509@1|root,COG3509@2|Bacteria,1N6M6@1224|Proteobacteria,42U8Z@68525|delta/epsilon subdivisions,2WQQT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	Esterase PHB depolymerase	-	-	-	ko:K03932	-	-	-	-	ko00000	-	CE1	-	Esterase_phd
REGS1_k127_4224275_1	251221.35210810	5.217e-31	127.0	COG5295@1|root,COG5295@2|Bacteria,1GB93@1117|Cyanobacteria	1117|Cyanobacteria	UW	Hep Hag repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_4224275_0	439481.Aboo_1333	7.934e-129	437.0	COG1002@1|root,COG2810@1|root,arCOG02636@1|root,arCOG08946@1|root,arCOG02635@2157|Archaea,arCOG02636@2157|Archaea,arCOG05724@2157|Archaea,arCOG08946@2157|Archaea,2Y89V@28890|Euryarchaeota	28890|Euryarchaeota	LV	Type I restriction-modification system methyltransferase subunit	-	-	-	-	-	-	-	-	-	-	-	-	Eco57I,N6_Mtase,TaqI_C
REGS1_k127_422813_1	1163617.SCD_n02394	4.955e-50	188.0	COG1216@1|root,COG1216@2|Bacteria,1RB30@1224|Proteobacteria,2VVJ1@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
REGS1_k127_422813_0	1121405.dsmv_2879	2.268e-93	317.0	COG0451@1|root,COG0451@2|Bacteria,1R4HG@1224|Proteobacteria,42ZCS@68525|delta/epsilon subdivisions,2WUGS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	GM	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
REGS1_k127_422813_2	1245475.ANAE01000133_gene4126	8.043e-24	106.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
REGS1_k127_4236821_0	1128421.JAGA01000003_gene3142	3.436e-113	377.0	COG0758@1|root,COG0758@2|Bacteria,2NP2V@2323|unclassified Bacteria	2|Bacteria	LU	DNA recombination-mediator protein A	dprA	-	5.99.1.2	ko:K03168,ko:K04096	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_processg_A
REGS1_k127_4236821_2	1232410.KI421424_gene1780	1.428e-34	136.0	COG0838@1|root,COG0838@2|Bacteria,1RGUT@1224|Proteobacteria,42UPV@68525|delta/epsilon subdivisions,2WQB6@28221|Deltaproteobacteria,43UXF@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3	nuoA	-	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
REGS1_k127_4236821_3	1121481.AUAS01000003_gene3840	5.655e-31	127.0	COG1905@1|root,COG1905@2|Bacteria,4NHIQ@976|Bacteroidetes,47JBB@768503|Cytophagia	976|Bacteroidetes	C	TIGRFAM NADH-quinone oxidoreductase, E subunit	nuoE	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
REGS1_k127_4236821_1	671143.DAMO_2695	8.593e-113	375.0	COG1005@1|root,COG1005@2|Bacteria,2NNTT@2323|unclassified Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
REGS1_k127_423803_3	1521187.JPIM01000188_gene1946	8.854e-180	585.0	COG4447@1|root,COG4447@2|Bacteria,2G66V@200795|Chloroflexi,3767C@32061|Chloroflexia	32061|Chloroflexia	G	glycosyl hydrolase, BNR repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_423803_10	1242864.D187_001537	6.215e-23	103.0	COG2258@1|root,COG2258@2|Bacteria,1RIAF@1224|Proteobacteria,42RG1@68525|delta/epsilon subdivisions,2WNX7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM MOSC domain	-	-	-	-	-	-	-	-	-	-	-	-	MOSC
REGS1_k127_423803_8	504728.K649_00235	2.454e-28	123.0	COG0560@1|root,COG0560@2|Bacteria,1WKQA@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	haloacid dehalogenase-like hydrolase	-	-	3.1.3.3	ko:K01079	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R00582	RC00017	ko00000,ko00001,ko00002,ko01000,ko01009	-	-	-	HAD
REGS1_k127_423803_7	511051.CSE_14850	9.8e-100	340.0	COG0312@1|root,COG0312@2|Bacteria	2|Bacteria	S	metallopeptidase activity	tldE2	-	-	-	-	-	-	-	-	-	-	-	PmbA_TldD
REGS1_k127_423803_4	309799.DICTH_1914	2.238e-166	536.0	COG0312@1|root,COG0312@2|Bacteria	2|Bacteria	S	metallopeptidase activity	tldD2	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
REGS1_k127_423803_6	457570.Nther_2188	1.86e-107	367.0	COG4805@1|root,COG4805@2|Bacteria	2|Bacteria	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
REGS1_k127_423803_1	340099.Teth39_0902	6.685e-222	700.0	COG1884@1|root,COG1884@2|Bacteria,1TQAD@1239|Firmicutes,24BDK@186801|Clostridia,42FIA@68295|Thermoanaerobacterales	186801|Clostridia	I	Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01847,ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
REGS1_k127_423803_9	926550.CLDAP_21640	3.709e-25	111.0	COG4770@1|root,COG4770@2|Bacteria	2|Bacteria	I	CoA carboxylase activity	pccA	-	6.4.1.3	ko:K01965,ko:K02160	ko00061,ko00280,ko00620,ko00630,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00620,map00630,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00373,M00376,M00741	R00742,R01859	RC00040,RC00097,RC00367,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
REGS1_k127_423803_2	926550.CLDAP_21630	1.886e-195	620.0	COG0439@1|root,COG0439@2|Bacteria,2G62X@200795|Chloroflexi	200795|Chloroflexi	I	Carbamoyl-phosphate synthetase large chain domain protein	accC	-	6.3.4.14,6.4.1.2,6.4.1.3,6.4.1.4	ko:K01961,ko:K01968,ko:K11263	ko00061,ko00280,ko00620,ko00630,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00620,map00630,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00036,M00082,M00376,M00741	R00742,R01859,R04138,R04385	RC00040,RC00097,RC00253,RC00367,RC00609,RC00942	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
REGS1_k127_423803_0	485913.Krac_12092	1.533e-259	807.0	COG4799@1|root,COG4799@2|Bacteria,2G5IX@200795|Chloroflexi	200795|Chloroflexi	I	PFAM carboxyl transferase	-	-	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
REGS1_k127_423803_5	326427.Cagg_0397	3.823e-140	456.0	COG1960@1|root,COG1960@2|Bacteria,2G65J@200795|Chloroflexi,374Z5@32061|Chloroflexia	32061|Chloroflexia	C	PFAM acyl-CoA dehydrogenase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
REGS1_k127_4264207_1	706587.Desti_4722	1.499e-54	207.0	COG1966@1|root,COG1966@2|Bacteria,1MWF9@1224|Proteobacteria,42NBI@68525|delta/epsilon subdivisions,2WM33@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	carbon starvation protein CstA	cstA	-	-	ko:K06200	-	-	-	-	ko00000	-	-	-	CstA,CstA_5TM
REGS1_k127_4264207_0	926569.ANT_02010	1.754e-94	316.0	COG2057@1|root,COG2057@2|Bacteria,2G6MS@200795|Chloroflexi	200795|Chloroflexi	I	Coenzyme A transferase	-	-	2.8.3.12	ko:K01040	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
REGS1_k127_4270499_1	869210.Marky_1035	7.155e-27	119.0	COG0785@1|root,COG0785@2|Bacteria,1WIZH@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	O	PFAM cytochrome c biogenesis protein, transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	DsbD
REGS1_k127_4270499_2	670487.Ocepr_0483	1.159e-22	107.0	COG3794@1|root,COG3794@2|Bacteria	2|Bacteria	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1
REGS1_k127_4270499_0	1128421.JAGA01000002_gene1307	1.642e-55	213.0	COG4585@1|root,COG4585@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K07777	ko02020,map02020	M00478	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	GAF,GAF_2,GAF_3,HATPase_c,HisKA_3,PAS,PAS_4,PAS_8
REGS1_k127_4270499_3	1123226.KB899291_gene228	9.396e-08	64.0	COG2199@1|root,COG2199@2|Bacteria,1TR65@1239|Firmicutes,4HBA6@91061|Bacilli,26RG7@186822|Paenibacillaceae	91061|Bacilli	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,dCache_1
REGS1_k127_4307769_3	649638.Trad_1980	1.651e-78	274.0	COG1609@1|root,COG1609@2|Bacteria,1WMBZ@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	K	PFAM Bacterial regulatory proteins, lacI family	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
REGS1_k127_4307769_4	1380390.JIAT01000009_gene1537	7.891e-69	253.0	COG1653@1|root,COG1653@2|Bacteria,2GJXB@201174|Actinobacteria,4CS8Q@84995|Rubrobacteria	84995|Rubrobacteria	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K10232	ko02010,map02010	M00201	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.32,3.A.1.1.8	-	-	SBP_bac_1
REGS1_k127_4307769_5	744872.Spica_0828	2.937e-63	228.0	COG1175@1|root,COG1175@2|Bacteria,2J5SW@203691|Spirochaetes	203691|Spirochaetes	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025,ko:K10233	ko02010,map02010	M00201,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.32,3.A.1.1.8	-	-	BPD_transp_1
REGS1_k127_4307769_1	1382306.JNIM01000001_gene1417	4.195e-90	308.0	COG0395@1|root,COG0395@2|Bacteria,2G82A@200795|Chloroflexi	200795|Chloroflexi	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K10234	ko02010,map02010	M00201	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.32,3.A.1.1.8	-	-	BPD_transp_1
REGS1_k127_4307769_6	192952.MM_1750	2.939e-09	70.0	arCOG02498@1|root,arCOG02498@2157|Archaea	2157|Archaea	M	parallel beta-helix repeat	-	-	-	-	-	-	-	-	-	-	-	-	NosD
REGS1_k127_4307769_0	1128421.JAGA01000004_gene2674	2.154e-227	715.0	COG0366@1|root,COG0366@2|Bacteria,2NQND@2323|unclassified Bacteria	2|Bacteria	G	Maltogenic Amylase, C-terminal domain	treS	-	3.2.1.1,5.4.99.16	ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R02108,R02112,R11262	RC01816	ko00000,ko00001,ko01000	-	GH13	-	APH,Alpha-amylase,Malt_amylase_C
REGS1_k127_4307769_2	471854.Dfer_5180	3.394e-85	307.0	COG3345@1|root,COG3345@2|Bacteria,4NJNN@976|Bacteroidetes,47NA3@768503|Cytophagia	976|Bacteroidetes	G	Melibiase	aglC	-	3.2.1.22	ko:K07407	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_36C,Glyco_hydro_36N,Melibiase
REGS1_k127_4312391_0	765420.OSCT_1723	1.165e-98	330.0	COG2141@1|root,COG2141@2|Bacteria,2G8PY@200795|Chloroflexi	200795|Chloroflexi	C	COGs COG2141 Coenzyme F420-dependent N5 N10-methylene tetrahydromethanopterin reductase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
REGS1_k127_4312391_2	383372.Rcas_3447	9.745e-39	155.0	COG1714@1|root,COG1714@2|Bacteria,2G7CB@200795|Chloroflexi,375N6@32061|Chloroflexia	32061|Chloroflexia	S	PFAM RDD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	RDD
REGS1_k127_4312391_1	1128421.JAGA01000002_gene1616	8.588e-79	273.0	COG1300@1|root,COG1300@2|Bacteria	2|Bacteria	CP	Membrane	-	-	-	ko:K06384	-	-	-	-	ko00000	-	-	-	SpoIIM
REGS1_k127_4351927_1	1382356.JQMP01000003_gene1897	2.083e-46	173.0	COG3358@1|root,COG3358@2|Bacteria,2G9CX@200795|Chloroflexi,27Z2J@189775|Thermomicrobia	189775|Thermomicrobia	S	Protein of unknown function (DUF1684)	-	-	-	ko:K09164	-	-	-	-	ko00000	-	-	-	DUF1684
REGS1_k127_4351927_0	926569.ANT_01830	0.0	1056.0	COG0587@1|root,COG0587@2|Bacteria,2G5IY@200795|Chloroflexi	200795|Chloroflexi	L	TIGRFAM DNA polymerase III, alpha subunit	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
REGS1_k127_4355240_1	255470.cbdbA1382	5.596e-128	417.0	COG1488@1|root,COG1488@2|Bacteria,2G73F@200795|Chloroflexi,34CMV@301297|Dehalococcoidia	301297|Dehalococcoidia	H	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP	pncB	-	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	-	QRPTase_C,QRPTase_N
REGS1_k127_4355240_0	861299.J421_3183	4.285e-154	497.0	COG0766@1|root,COG0766@2|Bacteria,1ZSZ5@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
REGS1_k127_4355240_2	383372.Rcas_1378	7.47e-34	134.0	COG1912@1|root,COG1912@2|Bacteria,2G6NI@200795|Chloroflexi,376J1@32061|Chloroflexia	32061|Chloroflexia	S	S-adenosyl-l-methionine hydroxide adenosyltransferase	-	-	-	ko:K22205	-	-	-	-	ko00000,ko01000	-	-	-	SAM_adeno_trans
REGS1_k127_4363654_0	926569.ANT_30090	2.421e-84	289.0	COG1235@1|root,COG1235@2|Bacteria,2G833@200795|Chloroflexi	200795|Chloroflexi	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
REGS1_k127_4363654_2	1449126.JQKL01000028_gene2572	2.188e-70	251.0	COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,247VG@186801|Clostridia,26886@186813|unclassified Clostridiales	186801|Clostridia	T	ATPase histidine kinase DNA gyrase B HSP90 domain protein	-	-	2.7.13.3	ko:K07651	ko02020,map02020	M00458	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
REGS1_k127_4363654_1	926569.ANT_00640	1.984e-74	256.0	COG0503@1|root,COG0503@2|Bacteria,2G8J8@200795|Chloroflexi	200795|Chloroflexi	F	Phosphoribosyl transferase domain	-	-	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
REGS1_k127_4363654_4	1499680.CCFE01000021_gene2156	2.691e-05	50.0	COG2102@1|root,COG2102@2|Bacteria,1V5NH@1239|Firmicutes,4HID4@91061|Bacilli,1ZDP8@1386|Bacillus	91061|Bacilli	S	Diphthamide synthase	-	-	-	-	-	-	-	-	-	-	-	-	Diphthami_syn_2
REGS1_k127_4363654_3	926560.KE387023_gene2217	6.833e-10	62.0	2DM9Y@1|root,32AJ6@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_4372627_5	1033806.HTIA_0930	2.082e-10	62.0	COG1501@1|root,arCOG03663@2157|Archaea,2XVVM@28890|Euryarchaeota,23UPD@183963|Halobacteria	183963|Halobacteria	G	Belongs to the glycosyl hydrolase 31 family	-	-	3.2.1.177,3.2.1.20	ko:K01187,ko:K01811	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	DUF4968,DUF5110,Gal_mutarotas_2,Glyco_hydro_31
REGS1_k127_4372627_7	1121895.Q765_16155	1.275e-08	66.0	COG2253@1|root,COG2253@2|Bacteria,4NME0@976|Bacteroidetes,1I5Q5@117743|Flavobacteriia,2NWRH@237|Flavobacterium	976|Bacteroidetes	S	Nucleotidyl transferase AbiEii toxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	AbiEii
REGS1_k127_4372627_3	765420.OSCT_0043	4.741e-59	221.0	COG0845@1|root,COG1566@1|root,COG0845@2|Bacteria,COG1566@2|Bacteria,2G93B@200795|Chloroflexi,3764W@32061|Chloroflexia	32061|Chloroflexia	MV	PFAM secretion protein HlyD family protein	-	-	-	ko:K01993	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_D23
REGS1_k127_4372627_1	439235.Dalk_2025	6.759e-94	317.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,42MV1@68525|delta/epsilon subdivisions,2WK9W@28221|Deltaproteobacteria,2MIZ9@213118|Desulfobacterales	28221|Deltaproteobacteria	V	PFAM ABC transporter	ybhF-C	-	-	ko:K01990,ko:K09695	ko02010,map02010	M00252,M00254	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.102	-	-	ABC_tran,DUF4162
REGS1_k127_4372627_2	1499967.BAYZ01000155_gene625	1.291e-88	302.0	COG1131@1|root,COG1131@2|Bacteria,2NQAN@2323|unclassified Bacteria	2|Bacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990,ko:K13926	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
REGS1_k127_4372627_0	765420.OSCT_0044	4.672e-119	394.0	COG0842@1|root,COG0842@2|Bacteria,2G6PG@200795|Chloroflexi,37723@32061|Chloroflexia	32061|Chloroflexia	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
REGS1_k127_4372627_4	1232437.KL661965_gene3213	4.041e-16	87.0	COG1309@1|root,COG1309@2|Bacteria,1MV2V@1224|Proteobacteria,42ZI7@68525|delta/epsilon subdivisions,2WU3E@28221|Deltaproteobacteria,2MN18@213118|Desulfobacterales	28221|Deltaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	ko:K13770	-	-	-	-	ko00000,ko03000	-	-	-	TetR_C_4,TetR_N
REGS1_k127_4372627_6	1173263.Syn7502_00617	1.023e-08	68.0	COG5635@1|root,COG5635@2|Bacteria,1G192@1117|Cyanobacteria,1GYCC@1129|Synechococcus	1117|Cyanobacteria	T	NTPase (NACHT family)	-	-	-	-	-	-	-	-	-	-	-	-	NACHT
REGS1_k127_4380629_3	926550.CLDAP_36700	4.591e-19	89.0	COG2188@1|root,COG2188@2|Bacteria,2G6ST@200795|Chloroflexi	200795|Chloroflexi	K	SPTR D1CI93 Phophonate C-P lyase system transcriptional regulator PhnF, GntR family	-	-	-	ko:K03710	-	-	-	-	ko00000,ko03000	-	-	-	GntR,UTRA
REGS1_k127_4380629_0	926550.CLDAP_36690	4.076e-135	441.0	COG3876@1|root,COG3876@2|Bacteria,2G655@200795|Chloroflexi	200795|Chloroflexi	S	Protein of unknown function (DUF1343)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1343
REGS1_k127_4380629_1	1128421.JAGA01000001_gene2312	2.114e-117	397.0	COG1653@1|root,COG1653@2|Bacteria,2NR86@2323|unclassified Bacteria	2|Bacteria	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
REGS1_k127_4380629_2	485913.Krac_7245	1.836e-70	250.0	COG1175@1|root,COG1175@2|Bacteria,2G8DB@200795|Chloroflexi	200795|Chloroflexi	G	COGs COG1175 ABC-type sugar transport systems permease components	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
REGS1_k127_4394986_3	234267.Acid_2204	3.376e-46	172.0	COG0698@1|root,COG0698@2|Bacteria	2|Bacteria	G	galactose-6-phosphate isomerase activity	upp	-	2.4.2.9,5.3.1.6	ko:K00761,ko:K01808	ko00030,ko00051,ko00240,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00240,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R00966,R01056,R09030	RC00063,RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	LacAB_rpiB,UPRTase
REGS1_k127_4394986_4	926550.CLDAP_32600	1.227e-45	173.0	COG0681@1|root,COG0681@2|Bacteria,2G701@200795|Chloroflexi	200795|Chloroflexi	U	Belongs to the peptidase S26 family	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
REGS1_k127_4394986_1	552398.HMPREF0866_02341	9.285e-122	402.0	COG0436@1|root,COG0436@2|Bacteria,1TP0J@1239|Firmicutes,247NQ@186801|Clostridia	186801|Clostridia	E	PFAM aminotransferase class I and II	-	-	-	ko:K10907	-	-	-	-	ko00000,ko01000,ko01007	-	-	-	Aminotran_1_2
REGS1_k127_4394986_0	479434.Sthe_0784	1.697e-160	515.0	COG0498@1|root,COG0498@2|Bacteria,2G5RK@200795|Chloroflexi,27Y4R@189775|Thermomicrobia	189775|Thermomicrobia	E	Threonine synthase	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
REGS1_k127_4394986_2	926550.CLDAP_00360	5.745e-108	358.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25
REGS1_k127_4394986_6	85643.Tmz1t_3898	1.385e-22	103.0	COG0463@1|root,COG0463@2|Bacteria,1MXC1@1224|Proteobacteria,2VPGH@28216|Betaproteobacteria,2KYIS@206389|Rhodocyclales	206389|Rhodocyclales	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
REGS1_k127_4403175_2	479434.Sthe_1657	5.632e-25	105.0	COG0648@1|root,COG0648@2|Bacteria,2G5XZ@200795|Chloroflexi,27XEG@189775|Thermomicrobia	189775|Thermomicrobia	L	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin	nfo	-	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
REGS1_k127_4403175_0	345341.KUTG_00683	2.003e-179	591.0	COG3292@1|root,COG3386@1|root,COG3292@2|Bacteria,COG3386@2|Bacteria,2IAXB@201174|Actinobacteria,4E9GM@85010|Pseudonocardiales	201174|Actinobacteria	GT	PFAM SMP-30 Gluconolaconase	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_4403175_1	515635.Dtur_1624	3.97e-54	197.0	COG0433@1|root,COG0433@2|Bacteria	2|Bacteria	S	helicase activity	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF853,DUF87,HAS-barrel
REGS1_k127_4403341_5	747365.Thena_1052	7.482e-07	53.0	COG1122@1|root,COG1122@2|Bacteria,1V16T@1239|Firmicutes,25B0D@186801|Clostridia,42EPN@68295|Thermoanaerobacterales	186801|Clostridia	P	pfam abc	-	-	-	ko:K02006	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	ABC_tran
REGS1_k127_4403341_1	926569.ANT_22440	1.399e-45	181.0	COG0760@1|root,COG0760@2|Bacteria,2G6RV@200795|Chloroflexi	200795|Chloroflexi	O	PFAM PpiC-type peptidyl-prolyl cis-trans isomerase	-	-	-	-	-	-	-	-	-	-	-	-	Rotamase,Rotamase_3,SurA_N_3
REGS1_k127_4403341_3	744872.Spica_1427	1.963e-21	98.0	COG0238@1|root,COG0238@2|Bacteria,2J8ZY@203691|Spirochaetes	203691|Spirochaetes	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit	rpsR	-	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
REGS1_k127_4403341_2	926569.ANT_22420	5.135e-43	161.0	COG0629@1|root,COG0629@2|Bacteria,2G6YE@200795|Chloroflexi	200795|Chloroflexi	L	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism	ssb	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
REGS1_k127_4403341_4	309801.trd_1249	4.797e-13	76.0	COG0360@1|root,COG0360@2|Bacteria,2G7DG@200795|Chloroflexi,27YM8@189775|Thermomicrobia	189775|Thermomicrobia	J	Binds together with S18 to 16S ribosomal RNA	rpsF	-	-	ko:K02990	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S6
REGS1_k127_4403341_0	867845.KI911784_gene3129	7.007e-53	193.0	COG1574@1|root,COG1574@2|Bacteria,2G5YJ@200795|Chloroflexi,375CQ@32061|Chloroflexia	32061|Chloroflexia	S	PFAM Amidohydrolase 3	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
REGS1_k127_440749_2	748247.AZKH_2774	5.39e-24	104.0	COG4274@1|root,COG4274@2|Bacteria,1N29P@1224|Proteobacteria,2WFXY@28216|Betaproteobacteria	28216|Betaproteobacteria	S	GYD domain	-	-	-	-	-	-	-	-	-	-	-	-	GYD
REGS1_k127_440749_3	290317.Cpha266_2626	0.0001207	47.0	COG3335@1|root,COG3335@2|Bacteria,1FEIY@1090|Chlorobi	1090|Chlorobi	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3
REGS1_k127_440749_0	926550.CLDAP_37440	3.43e-187	622.0	COG0744@1|root,COG0744@2|Bacteria,2G5ZG@200795|Chloroflexi	200795|Chloroflexi	M	PFAM glycosyl transferase, family 51	-	-	-	-	-	-	-	-	-	-	-	-	Transgly,Transpeptidase
REGS1_k127_4422444_2	926569.ANT_07760	9.546e-09	57.0	COG0388@1|root,COG0388@2|Bacteria,2G8XD@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	nadE	-	6.3.5.1	ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
REGS1_k127_4422444_0	926569.ANT_07770	2.756e-97	325.0	COG0171@1|root,COG0171@2|Bacteria,2G6X3@200795|Chloroflexi	200795|Chloroflexi	H	NAD synthase	-	-	6.3.1.5	ko:K01916	ko00760,ko01100,map00760,map01100	M00115	R00189	RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	NAD_synthase
REGS1_k127_4422444_1	357808.RoseRS_4300	2.976e-19	100.0	COG1807@1|root,COG1807@2|Bacteria,2G8TF@200795|Chloroflexi,376E7@32061|Chloroflexia	32061|Chloroflexia	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
REGS1_k127_4435664_10	443143.GM18_2427	5.806e-06	53.0	COG0500@1|root,COG2226@2|Bacteria,1RFGA@1224|Proteobacteria	1224|Proteobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23
REGS1_k127_4435664_1	1279009.ADICEAN_03694	1.337e-135	441.0	COG0451@1|root,COG0451@2|Bacteria,4NKVH@976|Bacteroidetes,47TKC@768503|Cytophagia	976|Bacteroidetes	GM	NAD(P)H-binding	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
REGS1_k127_4435664_0	383372.Rcas_0764	5.899e-155	511.0	COG0367@1|root,COG0367@2|Bacteria,2G7R3@200795|Chloroflexi,37669@32061|Chloroflexia	32061|Chloroflexia	F	TIGRFAM asparagine synthase (glutamine-hydrolyzing)	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
REGS1_k127_4435664_7	368407.Memar_1603	4.976e-47	182.0	COG0438@1|root,arCOG01411@2157|Archaea,2Y3MP@28890|Euryarchaeota	28890|Euryarchaeota	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
REGS1_k127_4435664_4	1163409.UUA_15798	1.787e-89	306.0	COG1216@1|root,COG1216@2|Bacteria,1QWEH@1224|Proteobacteria	1224|Proteobacteria	S	Glycosyl transferase family 2	-	-	2.4.1.60	ko:K13005	-	-	-	-	ko00000,ko01000,ko01003,ko01005	-	-	-	Glycos_transf_2
REGS1_k127_4435664_11	1038858.AXBA01000004_gene161	7.521e-05	51.0	COG0500@1|root,COG0500@2|Bacteria,1QV5S@1224|Proteobacteria,2TWAD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
REGS1_k127_4435664_2	1131266.ARWQ01000036_gene709	5.668e-107	360.0	arCOG01792@1|root,arCOG01792@2157|Archaea	2157|Archaea	K	Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_13,Methyltransf_14,Methyltransf_23
REGS1_k127_4435664_3	926550.CLDAP_10510	4.65e-95	330.0	COG2244@1|root,COG2244@2|Bacteria,2G7NK@200795|Chloroflexi	200795|Chloroflexi	S	PFAM polysaccharide biosynthesis protein	-	-	-	ko:K03328	-	-	-	-	ko00000	2.A.66.2	-	-	Polysacc_synt_3,Polysacc_synt_C
REGS1_k127_4435664_6	357808.RoseRS_1724	8.171e-62	220.0	COG0110@1|root,COG0110@2|Bacteria,2G7B9@200795|Chloroflexi,376QA@32061|Chloroflexia	32061|Chloroflexia	S	PFAM transferase hexapeptide repeat containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
REGS1_k127_4435664_5	867845.KI911784_gene2883	9.695e-73	256.0	COG0673@1|root,COG0673@2|Bacteria,2G6Y0@200795|Chloroflexi,376NR@32061|Chloroflexia	32061|Chloroflexia	S	PFAM oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
REGS1_k127_4435664_9	1121468.AUBR01000039_gene1933	6.216e-16	85.0	COG2445@1|root,COG2445@2|Bacteria,1VF87@1239|Firmicutes,24NYX@186801|Clostridia,42IK9@68295|Thermoanaerobacterales	186801|Clostridia	S	Protein of unknown function DUF86	-	-	-	-	-	-	-	-	-	-	-	-	DUF86
REGS1_k127_4435664_8	926569.ANT_19710	1.771e-21	94.0	COG0572@1|root,COG0572@2|Bacteria,2G6D5@200795|Chloroflexi	200795|Chloroflexi	F	Cytidine monophosphokinase	udk	GO:0003674,GO:0003824,GO:0004849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009224,GO:0009259,GO:0009260,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043097,GO:0043174,GO:0043771,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046035,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.7.1.48	ko:K00876	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PRK
REGS1_k127_444204_0	330214.NIDE2031	9.016e-147	470.0	COG1980@1|root,COG1980@2|Bacteria	2|Bacteria	G	fructose-bisphosphate aldolase activity	fbp	-	3.1.3.11,4.1.2.13	ko:K01622	ko00010,ko00030,ko00051,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00003	R00762,R01068,R01070,R02568,R04780	RC00017,RC00438,RC00439	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_3
REGS1_k127_444204_2	273057.SSO0085	1.555e-07	61.0	COG4353@1|root,arCOG01699@2157|Archaea,2XR1F@28889|Crenarchaeota	28889|Crenarchaeota	S	uncharacterised conserved protein UCP017998	-	-	-	-	-	-	-	-	-	-	-	-	DUF1122
REGS1_k127_444204_1	926550.CLDAP_00150	6.842e-19	92.0	COG0664@1|root,COG0664@2|Bacteria,2G902@200795|Chloroflexi	200795|Chloroflexi	C	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_6,Fer4_7,cNMP_binding
REGS1_k127_4451276_1	926550.CLDAP_03830	1.31e-122	401.0	COG0202@1|root,COG0202@2|Bacteria,2G5M9@200795|Chloroflexi	200795|Chloroflexi	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	GO:0003674,GO:0003824,GO:0003899,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
REGS1_k127_4451276_3	370438.PTH_0347	6.297e-76	260.0	COG0522@1|root,COG0522@2|Bacteria,1TR0J@1239|Firmicutes,248Y5@186801|Clostridia,260U9@186807|Peptococcaceae	186801|Clostridia	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	-	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
REGS1_k127_4451276_9	1128421.JAGA01000002_gene721	1.207e-47	175.0	COG0100@1|root,COG0100@2|Bacteria,2NPCN@2323|unclassified Bacteria	2|Bacteria	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome	rpsK	GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
REGS1_k127_4451276_7	1122223.KB890697_gene1231	4.146e-49	178.0	COG0099@1|root,COG0099@2|Bacteria,1WJY7@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
REGS1_k127_4451276_12	573370.DMR_12420	3.236e-13	69.0	COG0257@1|root,COG0257@2|Bacteria,1NGEI@1224|Proteobacteria,42WXD@68525|delta/epsilon subdivisions,2WSYK@28221|Deltaproteobacteria,2MDXC@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	Belongs to the bacterial ribosomal protein bL36 family	rpmJ	-	-	ko:K02919	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L36
REGS1_k127_4451276_2	868595.Desca_0233	4.477e-98	326.0	COG0024@1|root,COG0024@2|Bacteria,1TQC1@1239|Firmicutes,248I8@186801|Clostridia,260SK@186807|Peptococcaceae	186801|Clostridia	E	TIGRFAM methionine aminopeptidase, type I	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
REGS1_k127_4451276_4	1408304.JAHA01000006_gene667	5.264e-67	235.0	COG0563@1|root,COG0563@2|Bacteria,1TP27@1239|Firmicutes,247YN@186801|Clostridia,4BWW5@830|Butyrivibrio	186801|Clostridia	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iHN637.CLJU_RS20110	ADK,ADK_lid
REGS1_k127_4451276_0	926550.CLDAP_03900	4.302e-151	488.0	COG0201@1|root,COG0201@2|Bacteria,2G5X4@200795|Chloroflexi	200795|Chloroflexi	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
REGS1_k127_4451276_8	273068.TTE2273	4.677e-49	180.0	COG0200@1|root,COG0200@2|Bacteria,1V3KE@1239|Firmicutes,24HAJ@186801|Clostridia,42G84@68295|Thermoanaerobacterales	186801|Clostridia	J	Binds to the 23S rRNA	rplO	-	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
REGS1_k127_4451276_11	498761.HM1_1396	3.141e-15	78.0	COG1841@1|root,COG1841@2|Bacteria	2|Bacteria	J	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	rpmD	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
REGS1_k127_4451276_6	926569.ANT_10210	6.22e-62	220.0	COG0098@1|root,COG0098@2|Bacteria,2G6M9@200795|Chloroflexi	200795|Chloroflexi	J	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body	rpsE	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
REGS1_k127_4451276_10	1128421.JAGA01000002_gene713	4.264e-40	151.0	COG0256@1|root,COG0256@2|Bacteria,2NPVI@2323|unclassified Bacteria	2|Bacteria	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rplR	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18p
REGS1_k127_4451276_5	479434.Sthe_1051	6.045e-65	227.0	COG0097@1|root,COG0097@2|Bacteria,2G6HZ@200795|Chloroflexi,27Y65@189775|Thermomicrobia	189775|Thermomicrobia	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rplF	-	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
REGS1_k127_4467891_5	221288.JH992901_gene612	6.97e-42	166.0	COG2234@1|root,COG2234@2|Bacteria,1G4A2@1117|Cyanobacteria,1JI76@1189|Stigonemataceae	1117|Cyanobacteria	S	PA domain	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
REGS1_k127_4467891_1	1521187.JPIM01000043_gene1895	3.15e-96	326.0	COG0438@1|root,COG0438@2|Bacteria,2G5N9@200795|Chloroflexi,3755Z@32061|Chloroflexia	32061|Chloroflexia	M	PFAM glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
REGS1_k127_4467891_4	316274.Haur_4849	3.352e-44	168.0	COG0009@1|root,COG0009@2|Bacteria,2G673@200795|Chloroflexi,375TP@32061|Chloroflexia	32061|Chloroflexia	H	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine	-	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	SUA5,Sua5_yciO_yrdC
REGS1_k127_4467891_3	1382305.AZUC01000043_gene200	4.847e-46	178.0	COG0561@1|root,COG0561@2|Bacteria,1TR16@1239|Firmicutes,4HCZ6@91061|Bacilli,26I9Y@186818|Planococcaceae	91061|Bacilli	S	Sucrose-6F-phosphate phosphohydrolase	yxeH	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3
REGS1_k127_4467891_2	357808.RoseRS_3525	1.05e-64	231.0	COG2890@1|root,COG2890@2|Bacteria,2G6I8@200795|Chloroflexi,375AV@32061|Chloroflexia	32061|Chloroflexia	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0044424,GO:0044444,GO:0044464	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS
REGS1_k127_4467891_0	273068.TTE0143	1.056e-130	426.0	COG0216@1|root,COG0216@2|Bacteria,1TQ7V@1239|Firmicutes,248CN@186801|Clostridia,42FEW@68295|Thermoanaerobacterales	186801|Clostridia	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
REGS1_k127_4467891_6	926569.ANT_25910	3.15e-31	128.0	COG0728@1|root,COG0728@2|Bacteria,2G5MD@200795|Chloroflexi	2|Bacteria	S	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
REGS1_k127_4477332_0	926550.CLDAP_38200	1.243e-171	556.0	COG0086@1|root,COG0086@2|Bacteria,2G632@200795|Chloroflexi	200795|Chloroflexi	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
REGS1_k127_4477332_4	485913.Krac_9362	1.794e-74	257.0	COG2186@1|root,COG2186@2|Bacteria,2G959@200795|Chloroflexi	200795|Chloroflexi	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
REGS1_k127_4477332_3	485913.Krac_9361	8.994e-104	346.0	COG2084@1|root,COG2084@2|Bacteria,2G8RG@200795|Chloroflexi	200795|Chloroflexi	C	PFAM 6-phosphogluconate dehydrogenase NAD-binding	-	-	1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
REGS1_k127_4477332_2	485913.Krac_9360	2.348e-151	486.0	COG1071@1|root,COG1071@2|Bacteria,2G7RR@200795|Chloroflexi	200795|Chloroflexi	C	PFAM dehydrogenase E1 component	-	-	-	ko:K21416	-	-	-	-	ko00000,ko01000	-	-	-	E1_dh
REGS1_k127_4477332_1	1382306.JNIM01000001_gene2428	5.251e-163	517.0	COG0022@1|root,COG0022@2|Bacteria	2|Bacteria	C	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	acoB	-	-	ko:K21417	-	-	-	-	ko00000,ko01000	-	-	-	Transket_pyr,Transketolase_C
REGS1_k127_4477332_5	1159870.KB907784_gene499	9.82e-14	72.0	COG2267@1|root,COG2267@2|Bacteria,1R9GQ@1224|Proteobacteria,2VY6G@28216|Betaproteobacteria	28216|Betaproteobacteria	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
REGS1_k127_4478874_0	234267.Acid_0283	1.361e-128	419.0	COG0399@1|root,COG0399@2|Bacteria,3Y3PT@57723|Acidobacteria	57723|Acidobacteria	E	Belongs to the DegT DnrJ EryC1 family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
REGS1_k127_4478874_2	643648.Slip_0541	2.748e-17	88.0	2BHSI@1|root,32BW3@2|Bacteria,1UGN3@1239|Firmicutes,25P4Y@186801|Clostridia,42KN9@68298|Syntrophomonadaceae	186801|Clostridia	S	Domain of unknown function (DUF1992)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1992
REGS1_k127_4478874_1	383372.Rcas_0321	2.098e-76	262.0	COG2897@1|root,COG2897@2|Bacteria,2G6J9@200795|Chloroflexi,377XD@32061|Chloroflexia	32061|Chloroflexia	P	PFAM Rhodanese domain protein	-	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
REGS1_k127_4510153_5	485913.Krac_6502	2.654e-22	96.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_2,Big_3_3,LTD,PKD,Pro-kuma_activ,fn3
REGS1_k127_4510153_3	929562.Emtol_2637	6.055e-83	283.0	COG4221@1|root,COG4221@2|Bacteria,4PKGY@976|Bacteroidetes,47JKE@768503|Cytophagia	976|Bacteroidetes	S	PFAM Short-chain dehydrogenase reductase SDR	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
REGS1_k127_4510153_1	926550.CLDAP_20690	1.102e-115	383.0	COG0577@1|root,COG0577@2|Bacteria,2G6RX@200795|Chloroflexi	200795|Chloroflexi	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	-
REGS1_k127_4510153_2	926550.CLDAP_20700	2.04e-94	316.0	COG1136@1|root,COG1136@2|Bacteria,2G6K8@200795|Chloroflexi	200795|Chloroflexi	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
REGS1_k127_4510153_4	929562.Emtol_2637	2.814e-72	253.0	COG4221@1|root,COG4221@2|Bacteria,4PKGY@976|Bacteroidetes,47JKE@768503|Cytophagia	976|Bacteroidetes	S	PFAM Short-chain dehydrogenase reductase SDR	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
REGS1_k127_4510153_0	1396418.BATQ01000145_gene3545	8.821e-260	812.0	COG0330@1|root,COG0330@2|Bacteria,46TVK@74201|Verrucomicrobia	74201|Verrucomicrobia	O	SPFH domain / Band 7 family	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
REGS1_k127_4510153_6	1121405.dsmv_3253	0.0004444	48.0	COG0457@1|root,COG0457@2|Bacteria,1MZGK@1224|Proteobacteria,42US4@68525|delta/epsilon subdivisions,2X72T@28221|Deltaproteobacteria,2MPJC@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Tetratricopeptide TPR_2	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_2,TPR_6,TPR_8
REGS1_k127_4536055_4	383372.Rcas_1817	1.106e-09	62.0	2EI16@1|root,33BSP@2|Bacteria,2G9M5@200795|Chloroflexi,3761S@32061|Chloroflexia	32061|Chloroflexia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_4536055_3	935863.AWZR01000003_gene2744	1.161e-16	87.0	COG0484@1|root,COG0484@2|Bacteria,1MUZ4@1224|Proteobacteria,1RP09@1236|Gammaproteobacteria,1X3XU@135614|Xanthomonadales	135614|Xanthomonadales	O	Cytochrome C biogenesis protein	cbpA	-	-	ko:K05516	-	-	-	-	ko00000,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C
REGS1_k127_4536055_1	879212.DespoDRAFT_03512	5.285e-47	175.0	COG1061@1|root,COG1205@1|root,COG1061@2|Bacteria,COG1205@2|Bacteria,1QU0I@1224|Proteobacteria,42M4R@68525|delta/epsilon subdivisions,2WK1V@28221|Deltaproteobacteria,2MI86@213118|Desulfobacterales	28221|Deltaproteobacteria	L	DEAD DEAH box helicase	yprA	-	-	ko:K06877	-	-	-	-	ko00000	-	-	-	DEAD,DUF1998,Helicase_C,RNase_H_2
REGS1_k127_4536055_2	292459.STH2026	5.393e-29	122.0	COG1051@1|root,COG1051@2|Bacteria,1V466@1239|Firmicutes,24PBY@186801|Clostridia	186801|Clostridia	F	PFAM NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX,Nudix_N_2
REGS1_k127_4536055_0	251221.35212629	1.055e-90	305.0	COG0498@1|root,COG0498@2|Bacteria,1G0SV@1117|Cyanobacteria	1117|Cyanobacteria	E	Threonine synthase	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
REGS1_k127_456954_0	1382356.JQMP01000003_gene1688	1.271e-73	261.0	COG0665@1|root,COG0665@2|Bacteria,2G6HT@200795|Chloroflexi,27XXT@189775|Thermomicrobia	189775|Thermomicrobia	E	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
REGS1_k127_456954_2	525904.Tter_1734	3.935e-25	111.0	COG4243@1|root,COG4243@2|Bacteria	2|Bacteria	S	quinone binding	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_4,VKOR
REGS1_k127_456954_1	525904.Tter_1733	2.076e-32	130.0	COG1651@1|root,COG1651@2|Bacteria,2NPXE@2323|unclassified Bacteria	2|Bacteria	O	Thioredoxin	bdbD	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_4
REGS1_k127_4599895_3	472759.Nhal_0125	9.533e-10	63.0	2C5EY@1|root,32YQJ@2|Bacteria,1N8K7@1224|Proteobacteria,1SADI@1236|Gammaproteobacteria,1X1B4@135613|Chromatiales	135613|Chromatiales	S	Domain of unknown function (DUF4160)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4160
REGS1_k127_4599895_4	1499967.BAYZ01000148_gene1725	1.554e-06	55.0	2DNRM@1|root,32YT2@2|Bacteria,2NQ4W@2323|unclassified Bacteria	2|Bacteria	S	Protein of unknown function (DUF2442)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2442
REGS1_k127_4599895_0	1382306.JNIM01000001_gene1024	2.459e-114	377.0	COG1319@1|root,COG1319@2|Bacteria	2|Bacteria	C	xanthine dehydrogenase activity	hcrB	-	1.3.7.9	ko:K04109	ko00362,ko00627,ko01100,ko01120,ko01220,map00362,map00627,map01100,map01120,map01220	-	R05316	RC00490	ko00000,ko00001,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
REGS1_k127_4599895_1	1200792.AKYF01000009_gene3199	3.786e-44	166.0	COG0251@1|root,COG0251@2|Bacteria,1V6G4@1239|Firmicutes,4HMTM@91061|Bacilli,26XE2@186822|Paenibacillaceae	91061|Bacilli	J	YjgF/chorismate_mutase-like, putative endoribonuclease	-	-	-	-	-	-	-	-	-	-	-	-	YjgF_endoribonc
REGS1_k127_4599895_2	1382306.JNIM01000001_gene1025	5.058e-11	66.0	COG1541@1|root,COG1541@2|Bacteria,2G695@200795|Chloroflexi	200795|Chloroflexi	H	AMP-binding enzyme	-	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
REGS1_k127_4611437_3	765420.OSCT_2628	2.148e-53	192.0	COG2109@1|root,COG2109@2|Bacteria,2G6Q6@200795|Chloroflexi,375GV@32061|Chloroflexia	32061|Chloroflexia	H	PFAM ATP corrinoid adenosyltransferase BtuR CobO CobP	-	-	2.5.1.17	ko:K19221	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	CobA_CobO_BtuR
REGS1_k127_4611437_2	251221.35211140	2.528e-57	218.0	COG4559@1|root,COG4559@2|Bacteria	2|Bacteria	P	heme-transporting ATPase activity	hmuV	-	3.6.3.33,3.6.3.34	ko:K02013,ko:K06074	ko02010,map02010	M00240,M00241	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.13,3.A.1.14	-	-	ABC_tran
REGS1_k127_4611437_0	926569.ANT_02520	1.248e-94	323.0	COG0609@1|root,COG0609@2|Bacteria,2G6E8@200795|Chloroflexi	200795|Chloroflexi	P	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily	-	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
REGS1_k127_4611437_1	926569.ANT_02530	1.814e-77	271.0	COG0614@1|root,COG0614@2|Bacteria,2G6TS@200795|Chloroflexi	200795|Chloroflexi	P	periplasmic binding protein	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
REGS1_k127_4662008_1	1128421.JAGA01000002_gene1234	3.515e-41	166.0	COG2120@1|root,COG2120@2|Bacteria	2|Bacteria	S	N-acetylglucosaminylinositol deacetylase activity	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
REGS1_k127_4662008_2	1294142.CINTURNW_3625	9.09e-29	127.0	COG1295@1|root,COG1295@2|Bacteria,1U7HM@1239|Firmicutes,24A2Q@186801|Clostridia,36ESU@31979|Clostridiaceae	186801|Clostridia	S	Belongs to the UPF0761 family	yihY	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
REGS1_k127_4662008_3	935948.KE386495_gene2066	3.788e-09	66.0	COG0543@1|root,COG0543@2|Bacteria,1TQ5D@1239|Firmicutes,24AY2@186801|Clostridia,42GEQ@68295|Thermoanaerobacterales	186801|Clostridia	C	Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( )	pyrK	-	-	ko:K02823	ko00240,ko01100,map00240,map01100	-	-	-	ko00000,ko00001	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
REGS1_k127_4662008_0	1128421.JAGA01000002_gene1514	6.286e-269	844.0	COG0058@1|root,COG0058@2|Bacteria,2NNZS@2323|unclassified Bacteria	2|Bacteria	G	Carbohydrate phosphorylase	glgP	-	2.4.1.1,2.4.1.8	ko:K00688,ko:K00691	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R01555,R02111	RC00049	ko00000,ko00001,ko01000	-	GH65,GT35	-	DUF3417,Phosphorylase
REGS1_k127_4694853_2	1340434.AXVA01000024_gene3858	1.359e-08	61.0	COG1566@1|root,COG1566@2|Bacteria,1V1F5@1239|Firmicutes,4HG5R@91061|Bacilli,1ZQZ8@1386|Bacillus	91061|Bacilli	V	Barrel-sandwich domain of CusB or HlyD membrane-fusion	emrA	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
REGS1_k127_4694853_0	316274.Haur_0948	4.181e-262	822.0	COG1132@1|root,COG1132@2|Bacteria,2G5RP@200795|Chloroflexi,376W8@32061|Chloroflexia	32061|Chloroflexia	V	PFAM ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
REGS1_k127_4694853_1	765420.OSCT_1970	3.871e-12	68.0	COG1132@1|root,COG1132@2|Bacteria,2G63W@200795|Chloroflexi,376YV@32061|Chloroflexia	32061|Chloroflexia	P	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
REGS1_k127_4703505_0	926569.ANT_29620	1.444e-83	284.0	COG1180@1|root,COG1180@2|Bacteria,2G6B2@200795|Chloroflexi	200795|Chloroflexi	C	PFAM Radical SAM domain protein	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
REGS1_k127_4703505_1	926569.ANT_04560	6.213e-74	258.0	COG0796@1|root,COG0796@2|Bacteria,2G8GN@200795|Chloroflexi	200795|Chloroflexi	M	Provides the (R)-glutamate required for cell wall biosynthesis	murI	-	5.1.1.3	ko:K01776	ko00471,ko01100,map00471,map01100	-	R00260	RC00302	ko00000,ko00001,ko01000,ko01011	-	-	-	Asp_Glu_race
REGS1_k127_4703505_2	324602.Caur_0461	2.326e-59	214.0	COG2071@1|root,COG2071@2|Bacteria,2G6QN@200795|Chloroflexi,375KT@32061|Chloroflexia	32061|Chloroflexia	S	PFAM glutamine amidotransferase class-I	-	-	-	ko:K07010	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_C26
REGS1_k127_4703505_3	88036.EFJ31831	1.335e-11	64.0	COG1963@1|root,2QPKC@2759|Eukaryota,37KTI@33090|Viridiplantae,3G8ZJ@35493|Streptophyta	35493|Streptophyta	S	Acid phosphatase vanadium-dependent haloperoxidase-related protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF212
REGS1_k127_4736734_0	926569.ANT_14030	2.01e-206	664.0	COG0480@1|root,COG0480@2|Bacteria,2G680@200795|Chloroflexi	200795|Chloroflexi	J	elongation factor Tu domain 2 protein	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
REGS1_k127_4736734_1	1121930.AQXG01000020_gene103	3.668e-27	112.0	COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,4NE71@976|Bacteroidetes	976|Bacteroidetes	C	Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type	bfmBAB	-	1.2.4.4	ko:K11381	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,Transket_pyr,Transketolase_C
REGS1_k127_4758031_1	485913.Krac_10287	1.951e-142	462.0	COG0277@1|root,COG0277@2|Bacteria,2G5TM@200795|Chloroflexi	200795|Chloroflexi	C	PFAM FAD linked oxidase domain protein	-	-	1.1.2.4,1.1.3.15	ko:K00102,ko:K00104	ko00620,ko00630,ko01100,ko01110,ko01120,ko01130,map00620,map00630,map01100,map01110,map01120,map01130	-	R00197,R00475	RC00042,RC00044	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
REGS1_k127_4758031_0	926569.ANT_21050	4.088e-283	887.0	COG0402@1|root,COG1437@1|root,COG0402@2|Bacteria,COG1437@2|Bacteria,2G6DG@200795|Chloroflexi	200795|Chloroflexi	F	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine	mtaD	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,CYTH
REGS1_k127_4758031_4	1144275.COCOR_07974	2.489e-12	74.0	COG1388@1|root,COG3179@1|root,COG1388@2|Bacteria,COG3179@2|Bacteria,1MYUR@1224|Proteobacteria,42UGP@68525|delta/epsilon subdivisions,2WWB8@28221|Deltaproteobacteria,2YZ5E@29|Myxococcales	28221|Deltaproteobacteria	M	Chitinase class I	-	-	-	ko:K03791	-	-	-	-	ko00000	-	GH19	-	Glyco_hydro_19,LysM,PG_binding_1
REGS1_k127_4758031_3	1122927.KB895415_gene4528	3.937e-40	164.0	COG0477@1|root,COG2814@2|Bacteria,1TSVE@1239|Firmicutes,4HBXE@91061|Bacilli,26S8A@186822|Paenibacillaceae	91061|Bacilli	EGP	Major facilitator superfamily	snf3	-	-	-	-	-	-	-	-	-	-	-	MFS_1
REGS1_k127_4758031_5	479434.Sthe_0683	1.095e-08	63.0	COG1011@1|root,COG1011@2|Bacteria,2G74Q@200795|Chloroflexi	200795|Chloroflexi	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
REGS1_k127_4758031_2	1163671.JAGI01000002_gene2309	3.343e-58	224.0	COG1404@1|root,COG1404@2|Bacteria,1TQ2M@1239|Firmicutes,24CD5@186801|Clostridia,36JX7@31979|Clostridiaceae	186801|Clostridia	O	PFAM peptidase S8 and S53, subtilisin, kexin, sedolisin	-	-	3.4.21.66	ko:K08651,ko:K13274,ko:K14645,ko:K20486	ko02020,ko02024,map02020,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	Big_2,CW_binding_2,ChW,Peptidase_S8,SLH
REGS1_k127_4758456_4	926569.ANT_05010	1.654e-91	309.0	COG1234@1|root,COG1234@2|Bacteria,2G6YW@200795|Chloroflexi	200795|Chloroflexi	S	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA	rnz	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
REGS1_k127_4758456_8	765420.OSCT_1747	3.706e-44	178.0	COG0308@1|root,COG0308@2|Bacteria,2G6SD@200795|Chloroflexi,376VY@32061|Chloroflexia	32061|Chloroflexia	E	Peptidase MA superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_MA_2
REGS1_k127_4758456_15	926569.ANT_06190	1.16e-15	79.0	COG2835@1|root,COG2835@2|Bacteria	2|Bacteria	EG	tetraacyldisaccharide 4'-kinase activity	-	-	-	ko:K09791	-	-	-	-	ko00000	-	-	-	Methyltransf_11,Methyltransf_25,Trm112p
REGS1_k127_4758456_6	1128421.JAGA01000002_gene608	1.91e-45	172.0	COG0454@1|root,COG0456@2|Bacteria,2NPTV@2323|unclassified Bacteria	2|Bacteria	K	This enzyme acetylates the N-terminal alanine of ribosomal protein S18	rimI	-	2.3.1.128	ko:K03789,ko:K14742	-	-	-	-	ko00000,ko01000,ko03009,ko03016	-	-	-	Acetyltransf_1,Acetyltransf_10
REGS1_k127_4758456_9	383372.Rcas_0714	2.171e-43	168.0	COG1214@1|root,COG1214@2|Bacteria,2G6VT@200795|Chloroflexi,375PU@32061|Chloroflexia	32061|Chloroflexia	O	PFAM peptidase M22 glycoprotease	-	-	-	ko:K14742	-	-	-	-	ko00000,ko03016	-	-	-	Peptidase_M22
REGS1_k127_4758456_10	1423807.BACO01000065_gene2053	7.215e-36	144.0	COG0802@1|root,COG0802@2|Bacteria,1V6CV@1239|Firmicutes,4HIIF@91061|Bacilli,3F3MR@33958|Lactobacillaceae	91061|Bacilli	O	Hydrolase, P-loop family	ydiB	GO:0002949,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360	-	ko:K06925	-	-	-	-	ko00000,ko03016	-	-	-	TsaE
REGS1_k127_4758456_5	479434.Sthe_1642	1.177e-70	246.0	COG0639@1|root,COG0639@2|Bacteria,2G6GC@200795|Chloroflexi,27Y5S@189775|Thermomicrobia	189775|Thermomicrobia	T	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos_2
REGS1_k127_4758456_13	935837.JAEK01000014_gene5176	2.801e-23	112.0	COG1196@1|root,COG1196@2|Bacteria,1UIE6@1239|Firmicutes,4IT31@91061|Bacilli,1ZS8R@1386|Bacillus	91061|Bacilli	D	Domain of unknown function (DUF4349)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4349
REGS1_k127_4758456_12	309801.trd_1311	5.813e-28	115.0	COG1977@1|root,COG1977@2|Bacteria,2GBBB@200795|Chloroflexi,27Z8W@189775|Thermomicrobia	189775|Thermomicrobia	H	ThiS family	-	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
REGS1_k127_4758456_7	867845.KI911784_gene3037	3.464e-45	174.0	COG2897@1|root,COG2897@2|Bacteria,2G5XI@200795|Chloroflexi,374RX@32061|Chloroflexia	32061|Chloroflexia	P	PFAM Rhodanese domain protein	-	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
REGS1_k127_4758456_14	671143.DAMO_1027	5.145e-23	100.0	COG0425@1|root,COG0425@2|Bacteria,2NRUH@2323|unclassified Bacteria	2|Bacteria	O	Sulfurtransferase TusA	sirA	-	1.8.7.1	ko:K00392,ko:K04085	ko00920,ko01100,ko01120,ko04122,map00920,map01100,map01120,map04122	M00176	R00859,R03600	RC00065	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	NIR_SIR,NIR_SIR_ferr,TusA
REGS1_k127_4758456_11	234267.Acid_2639	7.399e-33	132.0	COG0454@1|root,COG0456@2|Bacteria,3Y5G1@57723|Acidobacteria	57723|Acidobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
REGS1_k127_4758456_1	1382359.JIAL01000001_gene1431	2.664e-119	389.0	COG0476@1|root,COG0476@2|Bacteria,3Y3IF@57723|Acidobacteria,2JIPC@204432|Acidobacteriia	204432|Acidobacteriia	HP	PFAM UBA THIF-type NAD FAD binding	-	-	2.7.7.80,2.8.1.11	ko:K21147	ko04122,map04122	-	R07459,R07461	RC00043	ko00000,ko00001,ko01000	-	-	-	Rhodanese,ThiF,ThiS
REGS1_k127_4758456_2	525904.Tter_1314	1.299e-108	360.0	COG0031@1|root,COG0031@2|Bacteria,2NP1M@2323|unclassified Bacteria	2|Bacteria	E	Pyridoxal-phosphate dependent enzyme	cysM	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004124,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0019344,GO:0019752,GO:0019842,GO:0030170,GO:0032991,GO:0033847,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0080146,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.5.1.113,2.5.1.47	ko:K12339,ko:K21148	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04122,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230,map04122	M00021	R00897,R03132,R03601,R04859,R10610	RC00020,RC02814,RC02821,RC02876,RC03225	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
REGS1_k127_4758456_3	926569.ANT_17980	5.461e-108	356.0	COG0396@1|root,COG0396@2|Bacteria,2G5S6@200795|Chloroflexi	200795|Chloroflexi	O	PFAM ABC transporter related	sufC	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
REGS1_k127_4758456_0	525904.Tter_1698	1.124e-197	622.0	COG0719@1|root,COG0719@2|Bacteria,2NNKT@2323|unclassified Bacteria	2|Bacteria	O	FeS assembly protein SufB	sufB	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0034641,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:1901360	-	ko:K07033,ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
REGS1_k127_4798991_0	316274.Haur_4070	2.736e-166	529.0	COG0056@1|root,COG0056@2|Bacteria,2G5YQ@200795|Chloroflexi,3759S@32061|Chloroflexia	32061|Chloroflexia	F	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
REGS1_k127_4843836_4	386456.JQKN01000017_gene841	0.0002456	48.0	arCOG12322@1|root,arCOG12322@2157|Archaea,2Y5I1@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_4843836_0	926550.CLDAP_05340	1.085e-132	430.0	COG1171@1|root,COG1171@2|Bacteria,2G5YN@200795|Chloroflexi	200795|Chloroflexi	E	Pyridoxal-phosphate dependent enzyme	-	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
REGS1_k127_4843836_2	1121087.AUCK01000031_gene3068	1.019e-11	72.0	COG3557@1|root,COG3557@2|Bacteria,1TRX8@1239|Firmicutes,4H9NM@91061|Bacilli,1ZB2J@1386|Bacillus	91061|Bacilli	J	Belongs to the UPF0374 family	ygaC	-	-	ko:K07586	-	-	-	-	ko00000	-	-	-	DUF402
REGS1_k127_4843836_1	485913.Krac_11873	6.766e-49	179.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	yxbD	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008080,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0044424,GO:0044464	3.2.2.20	ko:K01246	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Acetyltransf_1
REGS1_k127_4843836_3	1403819.BATR01000086_gene2522	3.861e-06	51.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	yhhY	-	-	ko:K03825	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1
REGS1_k127_4858894_2	926569.ANT_18220	1.252e-28	118.0	COG1143@1|root,COG1143@2|Bacteria,2G6SE@200795|Chloroflexi	200795|Chloroflexi	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	1.6.5.3	ko:K00338,ko:K03615	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4
REGS1_k127_4858894_1	1379698.RBG1_1C00001G0730	5.604e-29	122.0	COG1225@1|root,COG1225@2|Bacteria	2|Bacteria	O	peroxiredoxin activity	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,TPR_11,TPR_16,TPR_2,TPR_8,UnbV_ASPIC,VCBS
REGS1_k127_4858894_0	926569.ANT_31550	3.293e-40	157.0	COG0242@1|root,COG0242@2|Bacteria,2G6VE@200795|Chloroflexi	200795|Chloroflexi	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0018193,GO:0018206,GO:0019538,GO:0031365,GO:0036211,GO:0042586,GO:0043170,GO:0043412,GO:0043686,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
REGS1_k127_4858894_3	644966.Tmar_0118	5.835e-23	109.0	COG2009@1|root,COG2009@2|Bacteria,1VKGI@1239|Firmicutes,24VB1@186801|Clostridia	186801|Clostridia	C	TIGRFAM Succinate dehydrogenase, cytochrome b556 subunit	-	-	-	ko:K00241	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
REGS1_k127_4858894_4	644966.Tmar_0119	2.772e-19	98.0	COG2142@1|root,COG2142@2|Bacteria,1VP1A@1239|Firmicutes,24XAD@186801|Clostridia	186801|Clostridia	C	Succinate dehydrogenase/Fumarate reductase transmembrane subunit	-	-	-	ko:K00242	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
REGS1_k127_4861035_1	926550.CLDAP_11780	2.001e-88	298.0	COG1215@1|root,COG1215@2|Bacteria,2GBNZ@200795|Chloroflexi	200795|Chloroflexi	M	Glycosyltransferase like family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
REGS1_k127_4861035_3	552811.Dehly_1313	1.378e-33	138.0	COG0745@1|root,COG0745@2|Bacteria,2G6A5@200795|Chloroflexi,34D9D@301297|Dehalococcoidia	301297|Dehalococcoidia	K	Transcriptional regulatory protein, C terminal	-	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
REGS1_k127_4861035_2	1382306.JNIM01000001_gene167	6.057e-74	257.0	COG1922@1|root,COG1922@2|Bacteria,2G6J0@200795|Chloroflexi	200795|Chloroflexi	M	Belongs to the glycosyltransferase 26 family	-	-	2.4.1.187	ko:K05946	ko05111,map05111	-	-	-	ko00000,ko00001,ko01000,ko01003	-	GT26	-	Glyco_tran_WecB
REGS1_k127_4861035_0	926550.CLDAP_19050	3.866e-177	568.0	COG0160@1|root,COG0160@2|Bacteria,2G5KN@200795|Chloroflexi	200795|Chloroflexi	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.19	ko:K00823	ko00250,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
REGS1_k127_4861035_7	1121405.dsmv_1567	6.57e-05	53.0	2BWVJ@1|root,33YN1@2|Bacteria,1NXTC@1224|Proteobacteria,430BZ@68525|delta/epsilon subdivisions,2WVZK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_4861035_4	593750.Metfor_0759	2.838e-25	117.0	COG5635@1|root,arCOG02967@2157|Archaea,2Y7N5@28890|Euryarchaeota,2NB3I@224756|Methanomicrobia	224756|Methanomicrobia	T	PBS lyase HEAT-like repeat	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
REGS1_k127_4861035_5	525904.Tter_1193	6.381e-22	103.0	COG0671@1|root,COG0671@2|Bacteria	2|Bacteria	I	phosphatidate phosphatase activity	bcrC	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
REGS1_k127_4861035_6	429009.Adeg_2057	1.01e-13	70.0	COG2759@1|root,COG2759@2|Bacteria,1TP6N@1239|Firmicutes,247P5@186801|Clostridia,42FHK@68295|Thermoanaerobacterales	186801|Clostridia	F	PFAM formate-tetrahydrofolate ligase FTHFS	fhs	-	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
REGS1_k127_4868178_1	525904.Tter_1750	1.434e-140	454.0	COG0443@1|root,COG0443@2|Bacteria,2NNU1@2323|unclassified Bacteria	2|Bacteria	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
REGS1_k127_4868178_2	1128421.JAGA01000003_gene3369	1.294e-75	265.0	COG0673@1|root,COG0673@2|Bacteria,2NP86@2323|unclassified Bacteria	2|Bacteria	C	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
REGS1_k127_4868178_0	525904.Tter_0870	2.535e-164	534.0	COG1012@1|root,COG1012@2|Bacteria,2NNR8@2323|unclassified Bacteria	2|Bacteria	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.88	ko:K00294	ko00250,ko00330,ko01100,map00250,map00330,map01100	-	R00245,R00707,R00708,R04444,R04445,R05051	RC00080,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000	-	-	-	Aldedh
REGS1_k127_4868178_3	357808.RoseRS_2749	3.757e-11	67.0	COG0457@1|root,COG3063@1|root,COG0457@2|Bacteria,COG3063@2|Bacteria,2G9ET@200795|Chloroflexi,377NS@32061|Chloroflexia	32061|Chloroflexia	NU	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_2,TPR_8
REGS1_k127_4869464_5	316274.Haur_4170	3.363e-06	50.0	COG4283@1|root,COG4283@2|Bacteria,2G9ST@200795|Chloroflexi	2|Bacteria	S	Protein of unknown function (DUF1706)	M1-431	-	-	-	-	-	-	-	-	-	-	-	DUF1706
REGS1_k127_4869464_2	1476583.DEIPH_ctg050orf0040	9.673e-50	182.0	COG1765@1|root,COG1765@2|Bacteria	2|Bacteria	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC,TusA
REGS1_k127_4869464_0	926550.CLDAP_04800	3.58e-202	637.0	COG0065@1|root,COG0065@2|Bacteria,2G5IZ@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	-	-	4.2.1.114,4.2.1.33,4.2.1.35	ko:K01703,ko:K16792	ko00290,ko00300,ko00660,ko00680,ko00966,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00290,map00300,map00660,map00680,map00966,map01100,map01110,map01120,map01130,map01210,map01230	M00432,M00433,M00535,M00608	R03444,R03896,R03898,R03968,R04001,R04371,R08620,R08624,R08628,R08634,R08641,R08645,R09720,R10170,R10391,R10392,R10393,R10394,R10395,R10396	RC00497,RC00498,RC00618,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
REGS1_k127_4869464_1	82654.Pse7367_2223	1.48e-156	503.0	COG0119@1|root,COG0119@2|Bacteria,1G2SD@1117|Cyanobacteria,1HBM4@1150|Oscillatoriales	1117|Cyanobacteria	E	Belongs to the alpha-IPM synthase homocitrate synthase family	-	-	2.3.3.13,2.3.3.14	ko:K01649,ko:K01655	ko00290,ko00300,ko00620,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00290,map00300,map00620,map01100,map01110,map01120,map01130,map01210,map01230	M00030,M00432,M00433	R00271,R01213	RC00004,RC00067,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
REGS1_k127_4869464_4	1246995.AFR_19360	9.558e-17	87.0	COG1514@1|root,COG1514@2|Bacteria,2IKSA@201174|Actinobacteria	201174|Actinobacteria	J	2'-5' RNA ligase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	2_5_RNA_ligase2
REGS1_k127_4869464_3	926569.ANT_12380	1.613e-48	177.0	COG4992@1|root,COG4992@2|Bacteria,2G5SG@200795|Chloroflexi	200795|Chloroflexi	E	Catalyzes the transfer of the amino group of L-glutamate to LysW -aminoadipate 6-semialdehyde, generating LysW -gamma-L- lysine	lysJ	-	-	ko:K05830	ko00220,ko00300,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01130,map01210,map01230	M00031,M00763	R09778,R10932	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3,Peptidase_M20
REGS1_k127_4880798_0	926560.KE387025_gene3959	9.717e-113	375.0	COG1506@1|root,COG1506@2|Bacteria,1WNJA@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	X-Pro dipeptidyl-peptidase (S15 family)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S9
REGS1_k127_4880798_1	926550.CLDAP_05580	1.177e-32	132.0	COG1608@1|root,COG1608@2|Bacteria,2G6TH@200795|Chloroflexi	200795|Chloroflexi	S	PFAM aspartate glutamate uridylate kinase	-	-	2.7.4.26	ko:K06981	ko00900,ko01110,ko01130,map00900,map01110,map01130	-	R10093	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
REGS1_k127_4880969_2	1128421.JAGA01000001_gene2391	1.77e-31	128.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	ko:K16048	ko00984,ko01100,map00984,map01100	-	R09819	RC00236	ko00000,ko00001,ko01000	-	-	-	Flavin_Reduct,Methyltransf_11,Methyltransf_25,Methyltransf_31
REGS1_k127_4880969_0	479434.Sthe_2325	4.428e-100	336.0	COG0451@1|root,COG0451@2|Bacteria,2G9SG@200795|Chloroflexi	200795|Chloroflexi	GM	PFAM NAD-dependent epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
REGS1_k127_4880969_1	357808.RoseRS_3471	4.426e-82	290.0	COG0438@1|root,COG0438@2|Bacteria,2GB6D@200795|Chloroflexi,3753H@32061|Chloroflexia	32061|Chloroflexia	M	PFAM glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4
REGS1_k127_4894001_1	926550.CLDAP_04850	9.686e-48	173.0	COG0189@1|root,COG0189@2|Bacteria,2G5RN@200795|Chloroflexi	200795|Chloroflexi	HJ	Belongs to the RimK family	-	-	6.3.2.43	ko:K05827	ko00300,ko01100,ko01210,ko01230,map00300,map01100,map01210,map01230	M00031	R09775	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	RimK
REGS1_k127_4894001_0	926569.ANT_12400	3.873e-154	493.0	COG0002@1|root,COG0002@2|Bacteria,2G5W0@200795|Chloroflexi	200795|Chloroflexi	E	Catalyzes the NADPH-dependent reduction of LysW - aminoadipate 6-phosphate to yield LysW -aminoadipate 6- semialdehyde	lysY	-	-	ko:K05829	ko00220,ko00300,ko01100,ko01110,ko01210,ko01230,map00220,map00300,map01100,map01110,map01210,map01230	M00031,M00763	R09777,R10931	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
REGS1_k127_4894001_3	179408.Osc7112_4977	2.401e-32	130.0	2CCSR@1|root,32RWC@2|Bacteria,1GA04@1117|Cyanobacteria,1HDA0@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM S23 ribosomal protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
REGS1_k127_4894001_2	926569.ANT_12390	4.188e-45	169.0	COG0548@1|root,COG0548@2|Bacteria,2G5WV@200795|Chloroflexi	200795|Chloroflexi	E	Belongs to the acetylglutamate kinase family. LysZ subfamily	lysZ	-	-	ko:K05828	ko00220,ko00300,ko01100,ko01110,ko01210,ko01230,map00220,map00300,map01100,map01110,map01210,map01230	M00031,M00763	R09776,R10930	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
REGS1_k127_4897394_1	926569.ANT_19570	5.029e-55	211.0	COG1807@1|root,COG1807@2|Bacteria,2G79E@200795|Chloroflexi	200795|Chloroflexi	M	Protein of unknown function (DUF2723)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2723
REGS1_k127_4897394_0	926569.ANT_24700	2.162e-108	362.0	COG0012@1|root,COG0012@2|Bacteria,2G5UY@200795|Chloroflexi	200795|Chloroflexi	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
REGS1_k127_4897394_2	272557.APE_2466	1.641e-12	79.0	COG0477@1|root,arCOG00130@2157|Archaea,2XQRZ@28889|Crenarchaeota	28889|Crenarchaeota	G	Major Facilitator Superfamily	-	-	-	ko:K08161	-	-	-	-	ko00000,ko02000	2.A.1.2.20	-	-	MFS_1
REGS1_k127_4900454_1	309801.trd_0692	4.164e-75	258.0	COG0305@1|root,COG0305@2|Bacteria,2G64D@200795|Chloroflexi,27XKA@189775|Thermomicrobia	189775|Thermomicrobia	L	Participates in initiation and elongation during chromosome replication	-	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
REGS1_k127_4900454_2	926550.CLDAP_11970	2.827e-46	177.0	COG3935@1|root,COG3935@2|Bacteria,2G6W5@200795|Chloroflexi	200795|Chloroflexi	L	TIGRFAM primosome, DnaD subunit	-	-	-	-	-	-	-	-	-	-	-	-	DnaB_2
REGS1_k127_4900454_0	926550.CLDAP_11980	2.354e-132	437.0	COG1484@1|root,COG1484@2|Bacteria,2G65F@200795|Chloroflexi	200795|Chloroflexi	L	PFAM IstB domain protein ATP-binding protein	-	-	-	ko:K02315	-	-	-	-	ko00000,ko03032	-	-	-	IstB_IS21
REGS1_k127_4900454_3	926550.CLDAP_01950	3.263e-11	74.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	ko:K16648	-	-	-	-	ko00000,ko01000,ko01003	-	-	-	DUF3367,PMT_2
REGS1_k127_4915420_2	926569.ANT_05780	4.592e-39	150.0	COG2080@1|root,COG2080@2|Bacteria,2G6NT@200795|Chloroflexi	200795|Chloroflexi	C	2Fe-2S -binding domain protein	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
REGS1_k127_4915420_4	448385.sce2707	1.019e-08	63.0	2E8ZQ@1|root,33397@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_4915420_1	935840.JAEQ01000019_gene2104	3.497e-65	233.0	COG1319@1|root,COG1319@2|Bacteria,1RCRH@1224|Proteobacteria,2TU08@28211|Alphaproteobacteria,43PT0@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM	xdhB	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
REGS1_k127_4915420_3	891968.Anamo_0242	1.832e-36	145.0	COG1014@1|root,COG1014@2|Bacteria,3TAX4@508458|Synergistetes	508458|Synergistetes	C	indolepyruvate ferredoxin oxidoreductase, beta subunit	-	-	1.2.7.8	ko:K00180	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR
REGS1_k127_4915420_0	335543.Sfum_0387	1.238e-86	298.0	COG4231@1|root,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,42N44@68525|delta/epsilon subdivisions,2WKYE@28221|Deltaproteobacteria,2MQ87@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	iorA-2	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,POR_N,TPP_enzyme_C
REGS1_k127_4916968_2	1173020.Cha6605_5319	3.693e-26	111.0	COG1597@1|root,COG1597@2|Bacteria,1G0MV@1117|Cyanobacteria	1117|Cyanobacteria	I	PFAM Diacylglycerol kinase, catalytic	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
REGS1_k127_4916968_1	316274.Haur_3048	1.124e-43	177.0	COG0823@1|root,COG0823@2|Bacteria,2G8T8@200795|Chloroflexi,377EP@32061|Chloroflexia	32061|Chloroflexia	U	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	PD40
REGS1_k127_4916968_0	309801.trd_A0197	1.269e-82	281.0	COG1573@1|root,COG1573@2|Bacteria,2G8DF@200795|Chloroflexi,27YTA@189775|Thermomicrobia	189775|Thermomicrobia	L	Uracil DNA glycosylase superfamily	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
REGS1_k127_4921007_2	326427.Cagg_2827	1.636e-17	88.0	COG5305@1|root,COG5305@2|Bacteria,2G7AA@200795|Chloroflexi,375E4@32061|Chloroflexia	32061|Chloroflexia	S	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	DUF2723,PMT_2
REGS1_k127_4921007_1	383372.Rcas_0202	2.246e-84	287.0	COG1216@1|root,COG1216@2|Bacteria,2GBIQ@200795|Chloroflexi,374ZU@32061|Chloroflexia	32061|Chloroflexia	S	PFAM glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
REGS1_k127_4921007_0	1128421.JAGA01000002_gene1522	3.195e-127	409.0	COG0451@1|root,COG0451@2|Bacteria,2NQVT@2323|unclassified Bacteria	2|Bacteria	M	Polysaccharide biosynthesis protein	-	-	4.2.1.46,5.1.3.2	ko:K01710,ko:K01784,ko:K13318,ko:K13322,ko:K16439,ko:K19857	ko00052,ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00052,map00520,map00521,map00523,map00525,map01055,map01100,map01130	M00361,M00362,M00632,M00793,M00798,M00799,M00800	R00291,R02984,R06436,R06513,R06629,R11042,R11047	RC00182,RC00261,RC00289,RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
REGS1_k127_4932874_1	1367847.JCM7686_2804	6.733e-52	188.0	COG1177@1|root,COG1177@2|Bacteria,1MV4A@1224|Proteobacteria,2TUA3@28211|Alphaproteobacteria,2PUMG@265|Paracoccus	1224|Proteobacteria	E	Binding-protein-dependent transport system inner membrane component	IV02_22295	-	-	ko:K02053	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	BPD_transp_1
REGS1_k127_4932874_0	394.NGR_c21520	4.879e-74	253.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQMJ@28211|Alphaproteobacteria,4BAI9@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Belongs to the ABC transporter superfamily	potA-1	-	-	ko:K02052	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	ABC_tran,TOBE_2
REGS1_k127_4942727_6	765420.OSCT_0595	0.0008485	51.0	2A4NY@1|root,30TA0@2|Bacteria,2G9ZC@200795|Chloroflexi,377HD@32061|Chloroflexia	32061|Chloroflexia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_4942727_4	99598.Cal7507_5763	3.175e-28	125.0	2AFNQ@1|root,315Q9@2|Bacteria,1GK6V@1117|Cyanobacteria,1HTDE@1161|Nostocales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_4942727_3	316274.Haur_1024	3.826e-47	181.0	COG3173@1|root,COG3173@2|Bacteria,2G9DT@200795|Chloroflexi	200795|Chloroflexi	S	PFAM aminoglycoside phosphotransferase	-	-	2.7.1.163	ko:K18817	-	-	-	-	ko00000,ko01000,ko01504	-	-	-	APH
REGS1_k127_4942727_5	383372.Rcas_4400	2.274e-15	79.0	2DRCK@1|root,33B85@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Ribosomal_L12
REGS1_k127_4942727_1	926569.ANT_12370	4.097e-103	346.0	COG0624@1|root,COG0624@2|Bacteria,2G61X@200795|Chloroflexi	200795|Chloroflexi	E	Catalyzes the release of L-lysine from LysW -gamma-L- lysine	lysK	-	-	ko:K05831	ko00220,ko00300,ko01100,ko01210,ko01230,map00220,map00300,map01100,map01210,map01230	M00031,M00763	R09779,R10933	RC00064,RC00090	ko00000,ko00001,ko00002	-	-	-	Peptidase_M20
REGS1_k127_4942727_0	926550.CLDAP_04830	1.174e-115	381.0	COG0473@1|root,COG0473@2|Bacteria,2G66J@200795|Chloroflexi	200795|Chloroflexi	C	PFAM isocitrate isopropylmalate dehydrogenase	-	-	1.1.1.87	ko:K05824	ko00300,ko01100,ko01120,ko01130,ko01210,ko01230,map00300,map01100,map01120,map01130,map01210,map01230	M00030,M00433	R01934,R01936,R04862	RC00084,RC00114,RC00626	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
REGS1_k127_4942727_2	1382356.JQMP01000003_gene1333	1.633e-58	217.0	COG0066@1|root,COG0066@2|Bacteria,2G6PB@200795|Chloroflexi,27Y7V@189775|Thermomicrobia	200795|Chloroflexi	E	Belongs to the LeuD family	-	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
REGS1_k127_4959625_0	926550.CLDAP_06880	7.199e-190	605.0	COG1640@1|root,COG1640@2|Bacteria,2G668@200795|Chloroflexi	200795|Chloroflexi	G	PFAM glycoside hydrolase, family 77	malQ	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
REGS1_k127_5017873_7	316274.Haur_0750	1.633e-12	72.0	COG1302@1|root,COG1302@2|Bacteria,2G7GB@200795|Chloroflexi	200795|Chloroflexi	S	Asp23 family, cell envelope-related function	-	-	-	-	-	-	-	-	-	-	-	-	Asp23
REGS1_k127_5017873_0	1321778.HMPREF1982_02572	3.749e-87	294.0	COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,247PV@186801|Clostridia,26846@186813|unclassified Clostridiales	186801|Clostridia	IQ	Psort location Cytoplasmic, score	fabG	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
REGS1_k127_5017873_1	1042163.BRLA_c033440	3.66e-81	280.0	COG0331@1|root,COG0331@2|Bacteria,1TPB7@1239|Firmicutes,4HBCU@91061|Bacilli,26QJX@186822|Paenibacillaceae	91061|Bacilli	I	malonyl CoA-acyl carrier protein transacylase	fabD	-	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
REGS1_k127_5017873_6	1121377.KB906412_gene711	3.735e-16	81.0	COG0333@1|root,COG0333@2|Bacteria,1WKMA@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	J	Belongs to the bacterial ribosomal protein bL32 family	rpmF	GO:0003674,GO:0003735,GO:0005198	-	ko:K02911	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_L32p
REGS1_k127_5017873_4	1382306.JNIM01000001_gene3739	1.299e-38	151.0	COG1399@1|root,COG1399@2|Bacteria,2G6Z5@200795|Chloroflexi	200795|Chloroflexi	S	Uncharacterized ACR, COG1399	-	-	-	ko:K07040	-	-	-	-	ko00000	-	-	-	DUF177
REGS1_k127_5017873_5	926569.ANT_15290	4.887e-27	117.0	COG0711@1|root,COG0711@2|Bacteria,2G79J@200795|Chloroflexi	200795|Chloroflexi	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_5017873_3	552811.Dehly_1146	3.996e-49	181.0	COG0669@1|root,COG0669@2|Bacteria,2G6NZ@200795|Chloroflexi,34CR7@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	-	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
REGS1_k127_5017873_2	926569.ANT_15270	2.682e-63	220.0	COG1200@1|root,COG1200@2|Bacteria,2G5YM@200795|Chloroflexi	200795|Chloroflexi	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
REGS1_k127_5032058_3	926550.CLDAP_01110	1.564e-72	261.0	COG0728@1|root,COG0728@2|Bacteria,2G5MD@200795|Chloroflexi	200795|Chloroflexi	S	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	-	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
REGS1_k127_5032058_1	479434.Sthe_1002	1.973e-119	392.0	COG1494@1|root,COG1494@2|Bacteria,2G5XR@200795|Chloroflexi,27XXS@189775|Thermomicrobia	189775|Thermomicrobia	G	Bacterial fructose-1,6-bisphosphatase, glpX-encoded	-	-	3.1.3.11	ko:K02446	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00165,M00167	R00762,R04780	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_glpX
REGS1_k127_5032058_0	926550.CLDAP_04360	1.12e-193	612.0	COG1158@1|root,COG1158@2|Bacteria,2G5UQ@200795|Chloroflexi	200795|Chloroflexi	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
REGS1_k127_5032058_5	926569.ANT_09370	1.33e-52	199.0	COG0739@1|root,COG1388@1|root,COG0739@2|Bacteria,COG1388@2|Bacteria,2G6Q7@200795|Chloroflexi	200795|Chloroflexi	M	Peptidoglycan-binding LysM	-	-	-	-	-	-	-	-	-	-	-	-	LysM,Peptidase_M23,SH3_3
REGS1_k127_5032058_4	28072.Nos7524_2763	3.751e-65	237.0	COG0517@1|root,COG1994@1|root,COG0517@2|Bacteria,COG1994@2|Bacteria,1GC0N@1117|Cyanobacteria,1HR0M@1161|Nostocales	1117|Cyanobacteria	S	Belongs to the peptidase M50B family	-	-	-	-	-	-	-	-	-	-	-	-	CBS,Peptidase_M50
REGS1_k127_5032058_6	765420.OSCT_2975	1.994e-24	105.0	COG1550@1|root,COG1550@2|Bacteria,2G765@200795|Chloroflexi,375YB@32061|Chloroflexia	32061|Chloroflexia	S	Protein of unknown function (DUF503)	-	-	-	ko:K09764	-	-	-	-	ko00000	-	-	-	DUF503
REGS1_k127_5032058_2	867845.KI911784_gene2669	1.495e-105	349.0	COG1160@1|root,COG1160@2|Bacteria,2G5M0@200795|Chloroflexi,375A1@32061|Chloroflexia	32061|Chloroflexia	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
REGS1_k127_5067970_3	1382306.JNIM01000001_gene3652	3.549e-52	190.0	COG0179@1|root,COG0179@2|Bacteria,2G6HH@200795|Chloroflexi	200795|Chloroflexi	Q	PFAM fumarylacetoacetate (FAA) hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
REGS1_k127_5067970_4	926569.ANT_19500	8.882e-30	124.0	COG0250@1|root,COG0250@2|Bacteria	2|Bacteria	K	Participates in transcription elongation, termination and antitermination	rfaH	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141	-	ko:K02601,ko:K05785	-	-	-	-	ko00000,ko03000,ko03009,ko03021	-	-	-	KOW,NusG
REGS1_k127_5067970_1	479434.Sthe_2756	1.348e-146	474.0	COG0399@1|root,COG0399@2|Bacteria,2G7XI@200795|Chloroflexi	200795|Chloroflexi	E	DegT/DnrJ/EryC1/StrS aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
REGS1_k127_5067970_2	643648.Slip_0161	1.01e-112	394.0	COG1086@1|root,COG1086@2|Bacteria,1TR3W@1239|Firmicutes,247PW@186801|Clostridia,42JPY@68298|Syntrophomonadaceae	186801|Clostridia	GM	CoA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding_3,Polysacc_syn_2C,Polysacc_synt_2
REGS1_k127_5067970_5	926550.CLDAP_40260	5.634e-26	122.0	COG3307@1|root,COG3307@2|Bacteria	2|Bacteria	M	-O-antigen	-	-	-	ko:K13009,ko:K18814	-	-	-	-	ko00000,ko01000,ko01005,ko02000	9.B.67.1	-	-	Wzy_C
REGS1_k127_5067970_0	357808.RoseRS_3858	1.202e-194	625.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,2G5ZQ@200795|Chloroflexi,376AA@32061|Chloroflexia	32061|Chloroflexia	C	FAD linked oxidase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_8
REGS1_k127_5071969_1	485913.Krac_1674	2.552e-64	226.0	COG1595@1|root,COG1595@2|Bacteria,2G6PJ@200795|Chloroflexi	200795|Chloroflexi	K	PFAM sigma-70 region 2 domain protein	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2,SnoaL_2
REGS1_k127_5071969_0	1379698.RBG1_1C00001G1247	5.382e-83	282.0	COG3404@1|root,COG3643@1|root,COG3404@2|Bacteria,COG3643@2|Bacteria,2NNXZ@2323|unclassified Bacteria	2|Bacteria	E	Formiminotransferase-cyclodeaminase	ftcD	-	2.1.2.5,4.3.1.4	ko:K00603,ko:K01746,ko:K13990	ko00340,ko00670,ko01100,map00340,map00670,map01100	-	R02287,R02302,R03189	RC00165,RC00221,RC00223,RC00688,RC00870	ko00000,ko00001,ko01000,ko03036,ko04147	-	-	-	FTCD,FTCD_C,FTCD_N
REGS1_k127_509674_0	1267535.KB906767_gene2550	4.417e-112	372.0	COG0449@1|root,COG0449@2|Bacteria,3Y2NE@57723|Acidobacteria,2JI69@204432|Acidobacteriia	204432|Acidobacteriia	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
REGS1_k127_509674_1	926569.ANT_10810	2.671e-75	259.0	COG0283@1|root,COG0283@2|Bacteria,2G6I5@200795|Chloroflexi	200795|Chloroflexi	F	Belongs to the cytidylate kinase family. Type 1 subfamily	cmk	-	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin
REGS1_k127_509674_2	926561.KB900623_gene992	9.677e-59	215.0	COG1187@1|root,COG1187@2|Bacteria,1TP68@1239|Firmicutes,248UG@186801|Clostridia,3WAJX@53433|Halanaerobiales	186801|Clostridia	J	Belongs to the pseudouridine synthase RsuA family	rluB	-	5.4.99.19,5.4.99.22	ko:K06178,ko:K06183	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
REGS1_k127_509674_3	326427.Cagg_3848	5.207e-49	184.0	COG1386@1|root,COG1386@2|Bacteria,2G6V6@200795|Chloroflexi,375NU@32061|Chloroflexia	32061|Chloroflexia	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves	-	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
REGS1_k127_509674_4	1174528.JH992898_gene3099	3.432e-44	185.0	COG4485@1|root,COG4485@2|Bacteria,1GGV1@1117|Cyanobacteria	1117|Cyanobacteria	S	Bacterial membrane protein, YfhO	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_5112865_6	118173.KB235914_gene1555	5.982e-24	111.0	COG3429@1|root,COG3429@2|Bacteria,1G2UB@1117|Cyanobacteria,1H7B9@1150|Oscillatoriales	1117|Cyanobacteria	GM	PFAM Glucose-6-phosphate dehydrogenase subunit	opcA	-	-	-	-	-	-	-	-	-	-	-	OpcA_G6PD_assem,PG_binding_1
REGS1_k127_5112865_4	247490.KSU1_B0459	1.043e-68	248.0	COG0363@1|root,COG0363@2|Bacteria,2J0I5@203682|Planctomycetes	203682|Planctomycetes	G	Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase	pgl	-	3.1.1.31	ko:K01057	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R02035	RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucosamine_iso
REGS1_k127_5112865_2	479434.Sthe_1955	7.86e-119	393.0	COG3191@1|root,COG3191@2|Bacteria,2G83F@200795|Chloroflexi,27YT6@189775|Thermomicrobia	189775|Thermomicrobia	EQ	Peptidase family S58	-	-	3.4.11.19	ko:K01266	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S58
REGS1_k127_5112865_5	1125863.JAFN01000001_gene2998	1.161e-45	171.0	COG0521@1|root,COG0521@2|Bacteria,1R9W2@1224|Proteobacteria,42PGH@68525|delta/epsilon subdivisions,2WN91@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	molybdenum cofactor	-	-	-	-	-	-	-	-	-	-	-	-	MoCF_biosynth
REGS1_k127_5112865_1	269797.Mbar_A1244	3.877e-170	551.0	COG0520@1|root,arCOG00065@2157|Archaea	2157|Archaea	E	COG0520 Selenocysteine lyase	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
REGS1_k127_5112865_3	247490.KSU1_C0085	5.588e-82	276.0	COG0225@1|root,COG0225@2|Bacteria,2IZ67@203682|Planctomycetes	203682|Planctomycetes	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11,1.8.4.12	ko:K07304,ko:K12267	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
REGS1_k127_5112865_0	926561.KB900619_gene2526	1.924e-199	644.0	COG0249@1|root,COG0249@2|Bacteria,1TPRJ@1239|Firmicutes,248GI@186801|Clostridia,3WA7U@53433|Halanaerobiales	186801|Clostridia	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
REGS1_k127_5129345_0	358220.C380_06065	2.925e-267	844.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2VMF6@28216|Betaproteobacteria,4ABS8@80864|Comamonadaceae	28216|Betaproteobacteria	P	heavy metal translocating P-type ATPase	-	-	3.6.3.4	ko:K01533	-	-	R00086	RC00002	ko00000,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
REGS1_k127_5149396_3	204773.HEAR2140	7.094e-23	100.0	COG1359@1|root,COG1359@2|Bacteria,1NG3M@1224|Proteobacteria,2W4IR@28216|Betaproteobacteria,477TI@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
REGS1_k127_5149396_4	102129.Lepto7375DRAFT_0659	4.807e-06	51.0	COG3385@1|root,COG3385@2|Bacteria,1G2YX@1117|Cyanobacteria,1HERU@1150|Oscillatoriales	1117|Cyanobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
REGS1_k127_5149396_2	395493.BegalDRAFT_2283	4.477e-25	118.0	COG4641@1|root,COG4641@2|Bacteria,1R4AN@1224|Proteobacteria,1SGDZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	DUF based on E. rectale Gene description (DUF3880)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3880,Glyco_trans_1_2
REGS1_k127_5149396_5	751944.HALDL1_11040	1.008e-05	58.0	28HNE@1|root,2N5NI@2157|Archaea,2Y2AW@28890|Euryarchaeota,23ZHV@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_5149396_0	357808.RoseRS_4085	1.205e-66	237.0	COG0463@1|root,COG0463@2|Bacteria	2|Bacteria	M	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
REGS1_k127_5149396_1	234267.Acid_4357	6.9e-53	193.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	crtF	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_2,Methyltransf_23
REGS1_k127_5174625_1	1128421.JAGA01000002_gene1062	1.058e-27	124.0	COG5180@1|root,COG5180@2|Bacteria,2NRZJ@2323|unclassified Bacteria	2|Bacteria	A	pathogenesis	CP_0034	-	-	ko:K02417,ko:K02519	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044,ko03012,ko03029	3.A.6.2,3.A.6.3	-	-	GPDPase_memb
REGS1_k127_5174625_0	1128421.JAGA01000002_gene1061	9.406e-35	146.0	2EQIM@1|root,33I4N@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4129)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4129
REGS1_k127_5174625_2	357808.RoseRS_1833	1.388e-19	97.0	2E0NP@1|root,32W7Q@2|Bacteria,2G9D8@200795|Chloroflexi,375QK@32061|Chloroflexia	32061|Chloroflexia	S	Domain of unknown function (DUF4350)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4350
REGS1_k127_5179151_1	926569.ANT_11990	7.954e-49	179.0	COG1921@1|root,COG1921@2|Bacteria,2G5VV@200795|Chloroflexi	200795|Chloroflexi	H	Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis	selA	-	2.9.1.1	ko:K01042	ko00450,ko00970,map00450,map00970	-	R08219	RC01246	ko00000,ko00001,ko01000	-	-	-	Se-cys_synth_N,SelA
REGS1_k127_5179151_0	479434.Sthe_3320	1.677e-58	213.0	COG1682@1|root,COG1682@2|Bacteria,2G6QU@200795|Chloroflexi	200795|Chloroflexi	GM	PFAM ABC-2 type transporter	-	-	-	ko:K09690	ko02010,map02010	M00250	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.103	-	-	ABC2_membrane
REGS1_k127_5179151_2	1121904.ARBP01000017_gene5131	3.868e-14	82.0	2EBH5@1|root,335HP@2|Bacteria,4NW0F@976|Bacteroidetes,47VF8@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_5179151_3	1394178.AWOO02000018_gene6568	0.000579	49.0	COG0515@1|root,COG0515@2|Bacteria,2GIV0@201174|Actinobacteria,4EGJ4@85012|Streptosporangiales	201174|Actinobacteria	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
REGS1_k127_5186875_1	1297742.A176_00861	8.318e-44	181.0	COG0642@1|root,COG2205@2|Bacteria,1QX6V@1224|Proteobacteria,43BZK@68525|delta/epsilon subdivisions,2X7AC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_4
REGS1_k127_5186875_4	1203611.KB894547_gene2662	9.169e-06	55.0	COG3408@1|root,COG3408@2|Bacteria,4NESP@976|Bacteroidetes,2FMGH@200643|Bacteroidia	976|Bacteroidetes	G	Alpha-L-rhamnosidase N-terminal domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N
REGS1_k127_5186875_0	357808.RoseRS_2858	1.339e-48	184.0	COG3375@1|root,COG3375@2|Bacteria,2G8MH@200795|Chloroflexi,37765@32061|Chloroflexia	32061|Chloroflexia	M	carboxylic acid catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_5186875_2	525904.Tter_1056	1.906e-10	64.0	COG0828@1|root,COG0828@2|Bacteria,2NQ1U@2323|unclassified Bacteria	2|Bacteria	J	Ribosomal protein S21	rpsU	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02970	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S21
REGS1_k127_5186875_3	326427.Cagg_1868	4.609e-10	71.0	COG1480@1|root,COG1480@2|Bacteria,2G5WC@200795|Chloroflexi,375B2@32061|Chloroflexia	32061|Chloroflexia	S	PFAM metal-dependent phosphohydrolase, HD sub domain	-	-	-	ko:K07037	-	-	-	-	ko00000	-	-	-	7TM-7TMR_HD,7TMR-HDED,HD
REGS1_k127_5216466_2	502025.Hoch_4658	3.202e-18	86.0	COG1858@1|root,COG3420@1|root,COG1858@2|Bacteria,COG3420@2|Bacteria,1MV70@1224|Proteobacteria,42ZVA@68525|delta/epsilon subdivisions,2WVEX@28221|Deltaproteobacteria,2YU4Z@29|Myxococcales	28221|Deltaproteobacteria	C	cytochrome c peroxidase	-	-	1.11.1.5	ko:K00428	-	-	-	-	ko00000,ko01000	-	-	-	CCP_MauG
REGS1_k127_5216466_1	1183438.GKIL_2156	9.332e-34	145.0	COG1216@1|root,COG1216@2|Bacteria,1G3T8@1117|Cyanobacteria	1117|Cyanobacteria	S	Uncharacterised nucleotidyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_5
REGS1_k127_5216466_0	316274.Haur_4643	2.393e-74	277.0	COG1572@1|root,COG1572@2|Bacteria,2G7MU@200795|Chloroflexi,374XB@32061|Chloroflexia	2|Bacteria	S	Peptidase family C25	-	-	-	-	-	-	-	-	-	-	-	-	BatA,CARDB,Peptidase_M66,fn3
REGS1_k127_5216466_3	1236973.JCM9157_4218	1.241e-10	73.0	COG1388@1|root,COG3773@1|root,COG1388@2|Bacteria,COG3773@2|Bacteria,1TRFW@1239|Firmicutes,4ITW2@91061|Bacilli,1ZF2Q@1386|Bacillus	91061|Bacilli	M	Cell Wall Hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_2,LysM
REGS1_k127_5271794_21	342949.PNA2_0610	3.744e-05	48.0	COG0697@1|root,arCOG00271@2157|Archaea,2XYSZ@28890|Euryarchaeota,242TX@183968|Thermococci	183968|Thermococci	G	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
REGS1_k127_5271794_11	867903.ThesuDRAFT_01957	1.529e-33	138.0	COG0697@1|root,COG0697@2|Bacteria,1TRTP@1239|Firmicutes,25CFI@186801|Clostridia	186801|Clostridia	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
REGS1_k127_5271794_12	926550.CLDAP_01210	1.607e-33	140.0	2ETJ3@1|root,33M2W@2|Bacteria,2G7IK@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_5271794_18	568706.BN118_0043	5.709e-17	91.0	COG1989@1|root,COG1989@2|Bacteria,1MUZF@1224|Proteobacteria,2VI08@28216|Betaproteobacteria,3T4AI@506|Alcaligenaceae	28216|Betaproteobacteria	NOU	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue	outO	-	3.4.23.43	ko:K02654	-	M00331	-	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2	-	-	DiS_P_DiS,Peptidase_A24
REGS1_k127_5271794_15	926550.CLDAP_14760	3.381e-26	115.0	COG3063@1|root,COG3063@2|Bacteria,2G79Z@200795|Chloroflexi	200795|Chloroflexi	NU	Type IV pilus biogenesis stability protein PilW	-	-	-	-	-	-	-	-	-	-	-	-	zf-B_box
REGS1_k127_5271794_1	926550.CLDAP_00350	5.464e-167	543.0	COG0497@1|root,COG0497@2|Bacteria,2G5V1@200795|Chloroflexi	200795|Chloroflexi	L	May be involved in recombinational repair of damaged DNA	recN	-	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,SMC_N
REGS1_k127_5271794_20	765420.OSCT_1078	1.078e-06	60.0	COG1075@1|root,COG1075@2|Bacteria	2|Bacteria	KLT	acetyltransferases and hydrolases with the alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,DUF915,PGAP1
REGS1_k127_5271794_14	1210908.HSB1_16500	2.21e-26	114.0	COG2606@1|root,arCOG04332@2157|Archaea,2XY07@28890|Euryarchaeota,23WCK@183963|Halobacteria	183963|Halobacteria	S	YbaK prolyl-tRNA synthetase associated	ybaK	-	-	-	-	-	-	-	-	-	-	-	tRNA_edit
REGS1_k127_5271794_2	1121382.JQKG01000012_gene236	3.045e-114	378.0	COG0205@1|root,COG0205@2|Bacteria,1WM4B@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	-	-	2.7.1.11	ko:K00850	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
REGS1_k127_5271794_0	345341.KUTG_02723	5.194e-278	880.0	COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,2GNCW@201174|Actinobacteria,4E8J5@85010|Pseudonocardiales	201174|Actinobacteria	E	FAD dependent oxidoreductase central domain	-	-	1.5.3.19	ko:K19191	ko00760,ko01120,map00760,map01120	-	R10102	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO,FAO_M,GCV_T,GCV_T_C
REGS1_k127_5271794_9	926569.ANT_03610	9.57e-54	198.0	COG1708@1|root,COG1708@2|Bacteria,2G7IZ@200795|Chloroflexi	200795|Chloroflexi	S	Domain of unknown function (DUF4111)	-	-	2.7.7.47	ko:K00984	-	-	-	-	ko00000,ko01000,ko01504	-	-	-	DUF4111,NTP_transf_2
REGS1_k127_5271794_19	1112212.JH584235_gene1307	2.503e-15	89.0	COG1524@1|root,COG1524@2|Bacteria,1N5SF@1224|Proteobacteria,2TU7V@28211|Alphaproteobacteria,2K15Z@204457|Sphingomonadales	204457|Sphingomonadales	S	type I phosphodiesterase nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
REGS1_k127_5271794_6	1123023.JIAI01000003_gene2637	2.269e-66	236.0	COG0600@1|root,COG0600@2|Bacteria,2GKKZ@201174|Actinobacteria	201174|Actinobacteria	P	ABC-type nitrate sulfonate bicarbonate transport system permease component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
REGS1_k127_5271794_4	446470.Snas_5606	2.318e-90	306.0	COG1116@1|root,COG1116@2|Bacteria,2GN33@201174|Actinobacteria,4EZNM@85014|Glycomycetales	201174|Actinobacteria	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	AAA_assoc_C,ABC_tran
REGS1_k127_5271794_7	446470.Snas_5605	5.541e-60	221.0	COG0600@1|root,COG0600@2|Bacteria	2|Bacteria	P	ABC-type nitrate sulfonate bicarbonate transport system permease component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
REGS1_k127_5271794_16	67275.JOAP01000049_gene799	5.116e-20	103.0	COG0715@1|root,COG0715@2|Bacteria,2IDB4@201174|Actinobacteria	201174|Actinobacteria	P	NMT1/THI5 like	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
REGS1_k127_5271794_10	886293.Sinac_6609	2.328e-34	144.0	COG0726@1|root,COG0726@2|Bacteria,2J435@203682|Planctomycetes	203682|Planctomycetes	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
REGS1_k127_5271794_3	489825.LYNGBM3L_64070	5.083e-93	322.0	COG0438@1|root,COG0438@2|Bacteria,1G1X1@1117|Cyanobacteria,1H8D4@1150|Oscillatoriales	1117|Cyanobacteria	M	PFAM Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
REGS1_k127_5271794_8	1173028.ANKO01000030_gene3280	1.956e-55	213.0	COG2244@1|root,COG2244@2|Bacteria,1GCMK@1117|Cyanobacteria	1117|Cyanobacteria	S	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt
REGS1_k127_5271794_13	643648.Slip_1506	2.035e-32	143.0	COG0463@1|root,COG1807@1|root,COG2246@1|root,COG0463@2|Bacteria,COG1807@2|Bacteria,COG2246@2|Bacteria,1UJJF@1239|Firmicutes,25F4I@186801|Clostridia,42KDN@68298|Syntrophomonadaceae	186801|Clostridia	M	Glycosyltransferases involved in cell wall biogenesis-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,GtrA,PMT_2
REGS1_k127_5271794_17	511051.CSE_14410	8.68e-18	86.0	COG3842@1|root,COG3842@2|Bacteria	2|Bacteria	P	ATPase activity	potA	-	-	ko:K02052	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	ABC_tran,TOBE_2
REGS1_k127_5323643_1	926569.ANT_11080	3.103e-102	340.0	COG1486@1|root,COG1486@2|Bacteria,2G6IX@200795|Chloroflexi	200795|Chloroflexi	G	Family 4 glycosyl hydrolase	-	-	3.2.1.86	ko:K01222	ko00010,ko00500,map00010,map00500	-	R00839,R05133,R05134	RC00049,RC00171,RC00714	ko00000,ko00001,ko01000	-	GT4	-	Glyco_hydro_4,Glyco_hydro_4C
REGS1_k127_5323643_2	926569.ANT_11070	1.597e-73	261.0	COG2971@1|root,COG2971@2|Bacteria,2G764@200795|Chloroflexi	200795|Chloroflexi	G	BadF/BadG/BcrA/BcrD ATPase family	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG
REGS1_k127_5323643_0	383372.Rcas_0521	1.326e-163	528.0	COG2723@1|root,COG2723@2|Bacteria,2G67P@200795|Chloroflexi,3764G@32061|Chloroflexia	32061|Chloroflexia	G	PFAM glycoside hydrolase, family 1	-	-	3.2.1.21	ko:K05350	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_1
REGS1_k127_5323643_3	926550.CLDAP_13040	7.4e-30	119.0	COG1173@1|root,COG1173@2|Bacteria,2G6HB@200795|Chloroflexi	200795|Chloroflexi	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
REGS1_k127_5332930_1	926569.ANT_28890	1.375e-72	257.0	COG0697@1|root,COG0697@2|Bacteria,2G6ZR@200795|Chloroflexi	200795|Chloroflexi	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
REGS1_k127_5332930_0	357808.RoseRS_2871	2.046e-117	391.0	COG0744@1|root,COG0744@2|Bacteria,2G5ZG@200795|Chloroflexi,376FV@32061|Chloroflexia	32061|Chloroflexia	M	Penicillin-Binding Protein C-terminus Family	-	-	-	-	-	-	-	-	-	-	-	-	BiPBP_C,Transgly,Transpeptidase
REGS1_k127_5334585_5	311424.DhcVS_1445	4.334e-12	75.0	2A40N@1|root,30SJ6@2|Bacteria,2G9WM@200795|Chloroflexi,34DKR@301297|Dehalococcoidia	301297|Dehalococcoidia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_5334585_0	926569.ANT_09480	5.904e-52	201.0	COG0237@1|root,COG0237@2|Bacteria,2G6RQ@200795|Chloroflexi	200795|Chloroflexi	F	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	-	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CoaE
REGS1_k127_5334585_2	926569.ANT_11920	5.088e-26	123.0	COG1470@1|root,COG1470@2|Bacteria,2G6XR@200795|Chloroflexi	200795|Chloroflexi	S	Protein of unknown function (DUF3048) C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3048,DUF3048_C
REGS1_k127_5334585_1	326427.Cagg_2563	1.316e-29	136.0	COG5479@1|root,COG5479@2|Bacteria,2G970@200795|Chloroflexi,3763R@32061|Chloroflexia	32061|Chloroflexia	M	peptidoglycan receptor activity	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
REGS1_k127_53760_2	1382306.JNIM01000001_gene1023	2.862e-31	128.0	COG1529@1|root,COG1529@2|Bacteria	2|Bacteria	C	xanthine dehydrogenase activity	hcrA	-	1.3.7.9	ko:K04108	ko00362,ko00627,ko01100,ko01120,ko01220,map00362,map00627,map01100,map01120,map01220	-	R05316	RC00490	ko00000,ko00001,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
REGS1_k127_53760_0	536227.CcarbDRAFT_3973	2.126e-73	258.0	COG1073@1|root,COG1073@2|Bacteria,1V84C@1239|Firmicutes,24MJG@186801|Clostridia,36Q2H@31979|Clostridiaceae	186801|Clostridia	S	Prolyl oligopeptidase family	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4,Peptidase_S9
REGS1_k127_53760_1	1382306.JNIM01000001_gene1022	9.656e-67	231.0	COG2080@1|root,COG2080@2|Bacteria,2G6NT@200795|Chloroflexi	200795|Chloroflexi	C	2Fe-2S -binding domain protein	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
REGS1_k127_53760_3	264732.Moth_1780	6.603e-29	124.0	COG1414@1|root,COG1414@2|Bacteria,1TRMW@1239|Firmicutes,24BQA@186801|Clostridia,42G3H@68295|Thermoanaerobacterales	186801|Clostridia	K	Transcriptional regulator IclR	-	-	-	ko:K13641	-	-	-	-	ko00000,ko03000	-	-	-	HTH_IclR,IclR
REGS1_k127_5380188_4	1499683.CCFF01000015_gene3101	2.729e-17	83.0	COG4819@1|root,COG4819@2|Bacteria,1TQ6T@1239|Firmicutes,24BB7@186801|Clostridia,36ETS@31979|Clostridiaceae	186801|Clostridia	E	ethanolamine	eutA	-	-	ko:K04019	ko00564,ko01100,map00564,map01100	-	R00749	RC00370	ko00000,ko00001	-	-	-	EutA
REGS1_k127_5380188_2	1157490.EL26_07930	3.633e-59	212.0	COG1272@1|root,COG1272@2|Bacteria,1TSFK@1239|Firmicutes,4HAT2@91061|Bacilli	91061|Bacilli	S	protein, Hemolysin III	-	-	-	ko:K11068	-	-	-	-	ko00000,ko02042	-	-	-	HlyIII
REGS1_k127_5380188_3	1192034.CAP_5961	1.409e-17	94.0	COG0560@1|root,COG0560@2|Bacteria,1R4DN@1224|Proteobacteria,43240@68525|delta/epsilon subdivisions,2WXVH@28221|Deltaproteobacteria,2YYEZ@29|Myxococcales	28221|Deltaproteobacteria	E	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD
REGS1_k127_5380188_1	926550.CLDAP_14670	4.082e-99	338.0	COG3103@1|root,COG4991@2|Bacteria,2G8KJ@200795|Chloroflexi	200795|Chloroflexi	T	Glycosyltransferase WbsX	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_99
REGS1_k127_5380188_0	144197.XP_008279845.1	2.347e-129	422.0	COG0458@1|root,KOG0370@2759|Eukaryota,38CAC@33154|Opisthokonta,3B9FF@33208|Metazoa,3CS9A@33213|Bilateria,4804V@7711|Chordata,490QX@7742|Vertebrata,49UJ7@7898|Actinopterygii	33208|Metazoa	F	Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase	CAD	GO:0000050,GO:0000052,GO:0000166,GO:0001882,GO:0001884,GO:0002119,GO:0002134,GO:0002164,GO:0003674,GO:0003824,GO:0004070,GO:0004087,GO:0004088,GO:0004151,GO:0004672,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0006082,GO:0006139,GO:0006206,GO:0006207,GO:0006213,GO:0006220,GO:0006221,GO:0006228,GO:0006464,GO:0006468,GO:0006520,GO:0006525,GO:0006526,GO:0006541,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007275,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009208,GO:0009209,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009605,GO:0009653,GO:0009719,GO:0009725,GO:0009791,GO:0009887,GO:0009987,GO:0009991,GO:0010033,GO:0010243,GO:0016053,GO:0016301,GO:0016310,GO:0016363,GO:0016597,GO:0016740,GO:0016741,GO:0016743,GO:0016772,GO:0016773,GO:0016787,GO:0016810,GO:0016812,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0017144,GO:0018107,GO:0018130,GO:0018193,GO:0018210,GO:0019103,GO:0019240,GO:0019438,GO:0019538,GO:0019627,GO:0019637,GO:0019693,GO:0019752,GO:0019856,GO:0019899,GO:0022612,GO:0030424,GO:0030554,GO:0031406,GO:0031667,GO:0031974,GO:0031981,GO:0032501,GO:0032502,GO:0032549,GO:0032551,GO:0032553,GO:0032555,GO:0032557,GO:0032559,GO:0032868,GO:0032991,GO:0033267,GO:0034399,GO:0034404,GO:0034641,GO:0034654,GO:0035295,GO:0035639,GO:0036094,GO:0036211,GO:0036477,GO:0042221,GO:0042455,GO:0042594,GO:0042802,GO:0042995,GO:0043005,GO:0043025,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043195,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043434,GO:0043436,GO:0043603,GO:0043604,GO:0043679,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0044297,GO:0044306,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044456,GO:0044463,GO:0044464,GO:0045202,GO:0046051,GO:0046112,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046394,GO:0046483,GO:0046777,GO:0046872,GO:0046914,GO:0048513,GO:0048565,GO:0048731,GO:0048732,GO:0048856,GO:0050896,GO:0055086,GO:0055123,GO:0060465,GO:0070013,GO:0070335,GO:0070406,GO:0071704,GO:0071941,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:0097458,GO:0098793,GO:0120025,GO:0120038,GO:0140096,GO:0150034,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901652,GO:1901657,GO:1901659,GO:1901698,GO:1901700,GO:1905905	2.1.3.2,3.5.2.3,6.3.5.5	ko:K11540	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R01397,R01993,R10948,R10949	RC00002,RC00010,RC00043,RC00064,RC00632,RC02750,RC02798,RC02850,RC03314	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	Amidohydro_1,CPSase_L_D2,CPSase_L_D3,CPSase_sm_chain,GATase,MGS,OTCace,OTCace_N
REGS1_k127_5389018_6	926550.CLDAP_23400	6.098e-08	57.0	2EYH8@1|root,33RR4@2|Bacteria,2G7WE@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_5389018_3	926550.CLDAP_23410	4.889e-21	97.0	2FJCP@1|root,34B2I@2|Bacteria,2G94J@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_5389018_1	1382304.JNIL01000001_gene1675	7.065e-97	325.0	COG0395@1|root,COG0395@2|Bacteria,1TSYB@1239|Firmicutes,4HBHQ@91061|Bacilli,278DE@186823|Alicyclobacillaceae	91061|Bacilli	G	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
REGS1_k127_5389018_2	573413.Spirs_0720	4.477e-77	268.0	COG1175@1|root,COG1175@2|Bacteria	2|Bacteria	P	transmembrane transport	-	-	-	ko:K02025,ko:K05814,ko:K10118,ko:K10237,ko:K15771,ko:K17235,ko:K17238,ko:K17316	ko02010,map02010	M00196,M00198,M00204,M00207,M00491,M00599,M00602,M00605	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.16,3.A.1.1.17,3.A.1.1.2,3.A.1.1.24,3.A.1.1.28,3.A.1.1.3,3.A.1.1.30,3.A.1.1.34,3.A.1.1.38	-	-	BPD_transp_1
REGS1_k127_5389018_0	1501230.ET33_20940	2.354e-130	430.0	COG1653@1|root,COG1653@2|Bacteria,1TS64@1239|Firmicutes,4H9TH@91061|Bacilli,26QDP@186822|Paenibacillaceae	91061|Bacilli	G	ABC transporter substrate-binding protein	-	-	-	ko:K02027,ko:K05813	ko02010,map02010	M00198,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.3	-	-	SBP_bac_8
REGS1_k127_5389018_4	926550.CLDAP_39990	1.413e-19	95.0	COG1734@1|root,COG1734@2|Bacteria	2|Bacteria	T	zinc ion binding	dksA	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
REGS1_k127_5389018_5	880072.Desac_2318	7.426e-14	77.0	COG1030@1|root,COG1030@2|Bacteria,1MUJN@1224|Proteobacteria,42MWM@68525|delta/epsilon subdivisions,2WK3H@28221|Deltaproteobacteria,2MQRK@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	NfeD-like C-terminal, partner-binding	nfeD	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	CLP_protease,NfeD,SDH_sah
REGS1_k127_5412827_0	1340493.JNIF01000003_gene2680	1.119e-61	220.0	COG1215@1|root,COG1215@2|Bacteria,3Y5K6@57723|Acidobacteria	57723|Acidobacteria	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
REGS1_k127_5412827_1	543632.JOJL01000013_gene9386	1.372e-25	110.0	COG0748@1|root,COG0748@2|Bacteria,2I2TX@201174|Actinobacteria,4DF7H@85008|Micromonosporales	201174|Actinobacteria	P	F420H(2)-dependent quinone reductase	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red,Hemerythrin
REGS1_k127_5412827_2	485913.Krac_0209	6.541e-20	92.0	COG3293@1|root,COG3293@2|Bacteria,2G7ZQ@200795|Chloroflexi	200795|Chloroflexi	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_2,DUF4096
REGS1_k127_54229_1	1128421.JAGA01000003_gene2708	1.747e-76	265.0	COG0438@1|root,COG0438@2|Bacteria,2NQV5@2323|unclassified Bacteria	2|Bacteria	M	Glycosyltransferase Family 4	-	-	2.4.1.270	ko:K21369	-	-	-	-	ko00000,ko01000,ko01003	-	GT4	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
REGS1_k127_54229_0	926550.CLDAP_06990	5.135e-227	717.0	COG3408@1|root,COG3408@2|Bacteria	2|Bacteria	G	Glycogen debranching enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_63,Trehalase
REGS1_k127_54229_2	1380390.JIAT01000010_gene4351	3.72e-63	233.0	COG3511@1|root,COG3511@2|Bacteria,2II4P@201174|Actinobacteria	201174|Actinobacteria	M	Phosphoesterase family	-	-	-	-	-	-	-	-	-	-	-	-	Phosphoesterase
REGS1_k127_5446098_0	357808.RoseRS_3888	3.352e-100	344.0	COG2211@1|root,COG2211@2|Bacteria,2GA8Z@200795|Chloroflexi,3782P@32061|Chloroflexia	32061|Chloroflexia	G	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
REGS1_k127_5446098_1	502025.Hoch_4658	9.785e-93	318.0	COG1858@1|root,COG3420@1|root,COG1858@2|Bacteria,COG3420@2|Bacteria,1MV70@1224|Proteobacteria,42ZVA@68525|delta/epsilon subdivisions,2WVEX@28221|Deltaproteobacteria,2YU4Z@29|Myxococcales	28221|Deltaproteobacteria	C	cytochrome c peroxidase	-	-	1.11.1.5	ko:K00428	-	-	-	-	ko00000,ko01000	-	-	-	CCP_MauG
REGS1_k127_5461063_4	1487953.JMKF01000007_gene5886	4.403e-86	291.0	COG3408@1|root,COG3408@2|Bacteria,1G2AS@1117|Cyanobacteria,1H7MX@1150|Oscillatoriales	1117|Cyanobacteria	G	Glycogen debranching enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GDE_C,GDE_N
REGS1_k127_5461063_13	1452535.JARD01000028_gene2120	7.799e-13	81.0	COG1361@1|root,COG3291@1|root,COG1361@2|Bacteria,COG3291@2|Bacteria,2HFCG@201174|Actinobacteria,4FR1A@85023|Microbacteriaceae	201174|Actinobacteria	M	Domain of unknown function DUF11	-	-	-	-	-	-	-	-	-	-	-	-	DUF11
REGS1_k127_5461063_8	357808.RoseRS_2802	5.538e-62	235.0	COG1520@1|root,COG1520@2|Bacteria,2G9GE@200795|Chloroflexi,3774I@32061|Chloroflexia	32061|Chloroflexia	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_5461063_6	926550.CLDAP_10000	7.572e-76	268.0	COG0349@1|root,COG0349@2|Bacteria,2G74K@200795|Chloroflexi	200795|Chloroflexi	L	3'-5' exonuclease	-	-	3.1.13.5	ko:K03684	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DNA_pol_A_exo1,HRDC
REGS1_k127_5461063_12	293826.Amet_2890	1.133e-18	96.0	COG0682@1|root,COG0682@2|Bacteria,1TPAK@1239|Firmicutes,24APG@186801|Clostridia,36F3Y@31979|Clostridiaceae	186801|Clostridia	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
REGS1_k127_5461063_0	1382306.JNIM01000001_gene1224	1.274e-298	938.0	COG1109@1|root,COG1208@1|root,COG1109@2|Bacteria,COG1208@2|Bacteria,2G65W@200795|Chloroflexi	200795|Chloroflexi	M	PFAM transferase hexapeptide repeat containing protein	-	-	2.7.7.13,5.4.2.8	ko:K16881	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114,M00362	R00885,R01818	RC00002,RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase,PGM_PMM_I,PGM_PMM_II,PGM_PMM_III
REGS1_k127_5461063_3	1128421.JAGA01000002_gene1831	3.333e-87	296.0	COG1091@1|root,COG1091@2|Bacteria,2NPG4@2323|unclassified Bacteria	2|Bacteria	M	Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose	rfbD	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008831,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016051,GO:0016491,GO:0016614,GO:0016616,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0045226,GO:0046379,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	1.1.1.133,5.1.3.13,5.1.3.26	ko:K00067,ko:K01790,ko:K19997	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777,R06514	RC00182,RC01531	ko00000,ko00001,ko00002,ko01000	-	-	iECSF_1327.ECSF_1929,iEcHS_1320.EcHS_A2180,iJN678.rfbD	RmlD_sub_bind
REGS1_k127_5461063_2	1089550.ATTH01000001_gene925	2.717e-91	317.0	COG0491@1|root,COG0491@2|Bacteria,4NHXR@976|Bacteroidetes,1FJDJ@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	Metallo-beta-lactamase superfamily	-	-	3.5.2.6	ko:K17837	ko01501,map01501	-	R06363	RC01499	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
REGS1_k127_5461063_11	1496688.ER33_06230	7.075e-31	138.0	COG3453@1|root,COG3453@2|Bacteria,1G6UU@1117|Cyanobacteria	1117|Cyanobacteria	S	phosphatase (DUF442)	-	-	-	-	-	-	-	-	-	-	-	-	DUF442
REGS1_k127_5461063_1	1041146.ATZB01000012_gene3198	1.005e-125	420.0	COG2114@1|root,COG2114@2|Bacteria,1R51D@1224|Proteobacteria,2TT6W@28211|Alphaproteobacteria,4BBKC@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc
REGS1_k127_5461063_5	926550.CLDAP_00310	7.712e-82	287.0	COG0715@1|root,COG0715@2|Bacteria,2G6E9@200795|Chloroflexi	200795|Chloroflexi	P	PFAM NMT1 THI5 like domain protein	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
REGS1_k127_5461063_9	404589.Anae109_1809	7.881e-51	199.0	COG4585@1|root,COG4585@2|Bacteria,1N0JE@1224|Proteobacteria,42UG3@68525|delta/epsilon subdivisions,2WQFT@28221|Deltaproteobacteria,2Z1DF@29|Myxococcales	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA_3
REGS1_k127_5461063_7	644966.Tmar_1372	2.993e-67	236.0	COG2197@1|root,COG2197@2|Bacteria,1TQ1U@1239|Firmicutes,25B1X@186801|Clostridia,3WDTH@538999|Clostridiales incertae sedis	186801|Clostridia	K	helix_turn_helix, Lux Regulon	-	-	-	ko:K11618	ko02020,map02020	M00481,M00754	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
REGS1_k127_5461063_10	671143.DAMO_0766	5.677e-50	184.0	COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,2NNUW@2323|unclassified Bacteria	2|Bacteria	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	pcmB	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6,1.97.1.9	ko:K03388,ko:K12527	ko00450,ko00680,ko01100,ko01120,ko01200,map00450,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R07229,R11928,R11931,R11943,R11944	RC00011,RC02420	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_20,FlpD,Pyr_redox_2,Pyr_redox_3
REGS1_k127_5468932_3	511051.CSE_11690	2.134e-71	252.0	COG1173@1|root,COG1173@2|Bacteria	2|Bacteria	P	ABC-type dipeptide oligopeptide nickel transport systems, permease components	appC	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
REGS1_k127_5468932_2	324602.Caur_2783	8.591e-79	274.0	COG0601@1|root,COG0601@2|Bacteria,2G662@200795|Chloroflexi	200795|Chloroflexi	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
REGS1_k127_5468932_1	1499967.BAYZ01000054_gene4816	6.804e-90	318.0	COG0747@1|root,COG0747@2|Bacteria	2|Bacteria	E	dipeptide transport	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
REGS1_k127_5468932_0	326427.Cagg_2224	1.813e-117	389.0	COG1473@1|root,COG1473@2|Bacteria,2G7D3@200795|Chloroflexi,375H2@32061|Chloroflexia	32061|Chloroflexia	S	peptidase dimerisation domain protein	-	-	-	ko:K01436	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
REGS1_k127_5468932_4	309801.trd_0440	9.296e-29	119.0	COG2006@1|root,COG2006@2|Bacteria,2GA2Y@200795|Chloroflexi,27YWH@189775|Thermomicrobia	189775|Thermomicrobia	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
REGS1_k127_5485917_0	926569.ANT_19480	4.902e-122	406.0	COG1138@1|root,COG1138@2|Bacteria,2G5SZ@200795|Chloroflexi	200795|Chloroflexi	O	PFAM Cytochrome C assembly protein	ccmF	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
REGS1_k127_5485917_1	309801.trd_0263	6.455e-11	74.0	COG2010@1|root,COG2010@2|Bacteria,2G741@200795|Chloroflexi,27XRI@189775|Thermomicrobia	189775|Thermomicrobia	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
REGS1_k127_5511924_2	1123023.JIAI01000006_gene342	1.202e-41	161.0	COG0624@1|root,COG0624@2|Bacteria	2|Bacteria	E	succinyl-diaminopimelate desuccinylase activity	-	-	-	-	-	-	-	-	-	-	-	-	Dala_Dala_lig_C,M20_dimer,Peptidase_M20
REGS1_k127_5511924_3	868131.MSWAN_2092	1.371e-19	99.0	COG0778@1|root,arCOG00288@2157|Archaea,2XY3A@28890|Euryarchaeota	28890|Euryarchaeota	C	nitroreductase	-	-	1.13.11.79	ko:K04719	ko00740,ko01100,map00740,map01100	-	R09083	RC00435,RC02413	ko00000,ko00001,ko01000	-	-	-	Nitroreductase
REGS1_k127_5511924_1	1128421.JAGA01000004_gene2494	1.831e-51	187.0	COG0315@1|root,COG0315@2|Bacteria,2NPNE@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	GO:0002682,GO:0002683,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009605,GO:0009607,GO:0009987,GO:0016043,GO:0016829,GO:0016849,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0022607,GO:0031347,GO:0031348,GO:0034214,GO:0035821,GO:0040007,GO:0042802,GO:0043170,GO:0043207,GO:0043545,GO:0043933,GO:0044003,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044403,GO:0044413,GO:0044414,GO:0044419,GO:0045088,GO:0045824,GO:0046483,GO:0048519,GO:0048583,GO:0048585,GO:0050776,GO:0050777,GO:0050789,GO:0050896,GO:0051186,GO:0051188,GO:0051189,GO:0051259,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0051832,GO:0051833,GO:0052031,GO:0052037,GO:0052167,GO:0052170,GO:0052173,GO:0052200,GO:0052255,GO:0052261,GO:0052306,GO:0052309,GO:0052552,GO:0052553,GO:0052561,GO:0052562,GO:0052564,GO:0052572,GO:0061799,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0075136,GO:0080134,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
REGS1_k127_5511924_0	660470.Theba_0634	8.292e-86	297.0	COG0498@1|root,COG0498@2|Bacteria,2GDZQ@200918|Thermotogae	200918|Thermotogae	E	Pyridoxal-phosphate dependent enzyme	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
REGS1_k127_5549092_1	926550.CLDAP_02060	6.548e-73	276.0	COG1807@1|root,COG1807@2|Bacteria,2G8SF@200795|Chloroflexi	200795|Chloroflexi	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
REGS1_k127_5549092_2	697281.Mahau_0484	1.903e-32	131.0	COG0365@1|root,COG1956@1|root,COG0365@2|Bacteria,COG1956@2|Bacteria,1TQTI@1239|Firmicutes,25AZ5@186801|Clostridia,42FPZ@68295|Thermoanaerobacterales	186801|Clostridia	I	PFAM AMP-dependent synthetase	-	-	6.2.1.1,6.2.1.2	ko:K01895,ko:K01896	ko00010,ko00620,ko00640,ko00650,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00650,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01176,R01354	RC00004,RC00012,RC00014,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
REGS1_k127_5549092_0	443144.GM21_3997	8.527e-79	271.0	COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,42P7Z@68525|delta/epsilon subdivisions,2WK06@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
REGS1_k127_5573650_1	269797.Mbar_A1908	1.671e-64	246.0	arCOG03980@1|root,arCOG03980@2157|Archaea	2157|Archaea	S	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
REGS1_k127_5573650_2	479434.Sthe_2558	9.619e-63	237.0	COG1971@1|root,COG5305@1|root,COG1971@2|Bacteria,COG5305@2|Bacteria	2|Bacteria	P	manganese ion transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	Mntp,PMT_2
REGS1_k127_5573650_0	1121019.AUMN01000021_gene1257	1.195e-78	278.0	COG0624@1|root,COG0624@2|Bacteria,2GJDE@201174|Actinobacteria	201174|Actinobacteria	E	COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
REGS1_k127_5609813_2	684949.ATTJ01000001_gene904	1.271e-53	198.0	COG4585@1|root,COG4585@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE2,HATPase_c,HisKA_3
REGS1_k127_5609813_1	1121382.JQKG01000004_gene4091	4.094e-55	208.0	COG4315@1|root,COG4315@2|Bacteria	2|Bacteria	P	Pfam Secreted repeat of	MA20_31645	-	-	-	-	-	-	-	-	-	-	-	Lipoprotein_15
REGS1_k127_5609813_0	436308.Nmar_1322	6.878e-123	412.0	COG3569@1|root,arCOG08649@2157|Archaea,41SDH@651137|Thaumarchaeota	651137|Thaumarchaeota	L	DNA Topoisomerase I (eukaryota)	-	-	5.99.1.2	ko:K03163	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	Topo_C_assoc,Topoisom_I,Topoisom_I_N
REGS1_k127_5639998_0	479434.Sthe_1621	0.0	1339.0	COG0178@1|root,COG0178@2|Bacteria,2G60U@200795|Chloroflexi,27XGQ@189775|Thermomicrobia	189775|Thermomicrobia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	-
REGS1_k127_5639998_1	304371.MCP_0158	1.818e-10	70.0	arCOG01917@1|root,arCOG01917@2157|Archaea	2157|Archaea	M	deoxyhypusine monooxygenase activity	-	-	4.1.3.36	ko:K01661	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R07263	RC01923	ko00000,ko00001,ko00002,ko01000	-	-	-	DZR,ECH_1,FHA,zf-ribbon_3,zinc_ribbon_2
REGS1_k127_5641962_3	1306174.JODP01000027_gene108	1.847e-09	68.0	2EPZ4@1|root,33HJQ@2|Bacteria,2GYV7@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_5641962_1	765420.OSCT_0550	3.599e-85	287.0	COG0745@1|root,COG0745@2|Bacteria,2GBT3@200795|Chloroflexi,376HQ@32061|Chloroflexia	32061|Chloroflexia	K	Two component transcriptional regulator, winged helix family	-	-	-	ko:K07658	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
REGS1_k127_5641962_0	357808.RoseRS_3736	5.076e-101	347.0	COG0642@1|root,COG5000@1|root,COG2205@2|Bacteria,COG5000@2|Bacteria,2GBIC@200795|Chloroflexi,3780I@32061|Chloroflexia	32061|Chloroflexia	T	histidine kinase A domain protein	-	-	2.7.13.3	ko:K02484	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
REGS1_k127_5641962_2	86416.Clopa_1117	9.063e-12	74.0	COG1585@1|root,COG1585@2|Bacteria,1VD3E@1239|Firmicutes,24H38@186801|Clostridia,36IDP@31979|Clostridiaceae	186801|Clostridia	OU	Membrane protein implicated in regulation of membrane protease activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF1449,NfeD
REGS1_k127_5728_0	485913.Krac_12022	1.999e-163	524.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2G5W2@200795|Chloroflexi	200795|Chloroflexi	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
REGS1_k127_5728_9	515635.Dtur_0271	3.199e-34	139.0	COG1285@1|root,COG1285@2|Bacteria	2|Bacteria	E	pathogenesis	sapB	-	-	ko:K07507	-	-	-	-	ko00000,ko02000	9.B.20	-	-	MgtC
REGS1_k127_5728_1	383372.Rcas_0256	2.459e-131	441.0	COG0358@1|root,COG0358@2|Bacteria,2G65X@200795|Chloroflexi,3753F@32061|Chloroflexia	32061|Chloroflexia	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,Toprim_4,Toprim_N,zf-CHC2
REGS1_k127_5728_2	398512.JQKC01000020_gene4050	6.688e-110	372.0	COG0568@1|root,COG0568@2|Bacteria,1TPD6@1239|Firmicutes,2481I@186801|Clostridia,3WGMV@541000|Ruminococcaceae	186801|Clostridia	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	sigA	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
REGS1_k127_5728_8	1499967.BAYZ01000019_gene6325	1.145e-48	192.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
REGS1_k127_5728_3	324602.Caur_0032	4.45e-101	343.0	COG1063@1|root,COG1063@2|Bacteria,2G5WZ@200795|Chloroflexi,376KB@32061|Chloroflexia	32061|Chloroflexia	E	PFAM Alcohol dehydrogenase zinc-binding domain protein	-	-	1.1.1.1	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
REGS1_k127_5728_6	926569.ANT_31760	4.415e-66	235.0	COG1428@1|root,COG1428@2|Bacteria	2|Bacteria	F	Deoxynucleoside kinase	dgk	-	2.7.1.113	ko:K15518	ko00230,map00230	-	R01967	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	HPPK,dNK
REGS1_k127_5728_5	926569.ANT_28360	9.591e-76	261.0	COG1428@1|root,COG1428@2|Bacteria,2G8PM@200795|Chloroflexi	200795|Chloroflexi	F	PFAM deoxynucleoside kinase	-	-	-	-	-	-	-	-	-	-	-	-	dNK
REGS1_k127_5728_7	525904.Tter_1300	2.509e-61	223.0	COG0382@1|root,COG0382@2|Bacteria	2|Bacteria	H	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate	-	-	2.5.1.74	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R05617,R06858,R10757	RC02935,RC02936,RC03264	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
REGS1_k127_5728_4	768706.Desor_3029	1.855e-79	275.0	COG0329@1|root,COG0329@2|Bacteria,1TPSG@1239|Firmicutes,24H6N@186801|Clostridia,263YQ@186807|Peptococcaceae	186801|Clostridia	H	Belongs to the DapA family	-	-	4.1.3.16	ko:K18123	ko00330,ko00630,ko01100,map00330,map00630,map01100	-	R00470,R00471	RC00307,RC00308	ko00000,ko00001,ko01000	-	-	-	DHDPS
REGS1_k127_5728_10	1307436.PBF_24603	3.743e-09	64.0	COG0737@1|root,COG3023@1|root,COG0737@2|Bacteria,COG3023@2|Bacteria,1UMPG@1239|Firmicutes,4ITXY@91061|Bacilli,1ZID2@1386|Bacillus	91061|Bacilli	F	N-Acetylmuramoyl-L-alanine amidase	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_2
REGS1_k127_5744939_1	525904.Tter_1072	8.968e-46	174.0	COG0642@1|root,COG2205@2|Bacteria	525904.Tter_1072|-	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_5744939_0	1382306.JNIM01000001_gene325	2.254e-58	211.0	COG0745@1|root,COG0745@2|Bacteria	1382306.JNIM01000001_gene325|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_5744939_2	926550.CLDAP_22720	1.088e-31	143.0	COG0451@1|root,COG0451@2|Bacteria,2G74B@200795|Chloroflexi	200795|Chloroflexi	GM	Protein of unknown function (DUF4012)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4012
REGS1_k127_5744939_3	1408473.JHXO01000005_gene1630	2.884e-10	63.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,4NHS5@976|Bacteroidetes,2FN1K@200643|Bacteroidia	976|Bacteroidetes	EU	Peptidase, S9A B C family, catalytic domain protein	pop	GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0008239,GO:0009056,GO:0009987,GO:0016787,GO:0019538,GO:0033218,GO:0034641,GO:0042277,GO:0042597,GO:0042802,GO:0042803,GO:0043170,GO:0043171,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044464,GO:0046983,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
REGS1_k127_5748103_1	395961.Cyan7425_0749	6.18e-92	319.0	COG2199@1|root,COG3706@2|Bacteria	2|Bacteria	T	GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	HisKA,PAS_8,PAS_9,Response_reg,SpoIIE
REGS1_k127_5748103_2	395493.BegalDRAFT_1434	3.351e-57	201.0	COG0745@1|root,COG0745@2|Bacteria,1RD7E@1224|Proteobacteria,1S6VP@1236|Gammaproteobacteria,462PR@72273|Thiotrichales	72273|Thiotrichales	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
REGS1_k127_5748103_0	1173027.Mic7113_4161	2.631e-223	732.0	COG2199@1|root,COG2202@1|root,COG5002@1|root,COG2202@2|Bacteria,COG3706@2|Bacteria,COG5002@2|Bacteria,1GQ1T@1117|Cyanobacteria,1HHSH@1150|Oscillatoriales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS_4,Response_reg
REGS1_k127_5748103_3	1173024.KI912149_gene6518	2.038e-38	154.0	COG0814@1|root,COG0814@2|Bacteria,1G4RP@1117|Cyanobacteria	1117|Cyanobacteria	E	amino acid	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_5770966_2	1118054.CAGW01000005_gene3791	1.498e-102	344.0	COG0001@1|root,COG0001@2|Bacteria,1TPNH@1239|Firmicutes,4HANQ@91061|Bacilli,26QYR@186822|Paenibacillaceae	91061|Bacilli	H	Glutamate-1-semialdehyde aminotransferase	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
REGS1_k127_5770966_1	485913.Krac_2131	2.666e-144	466.0	COG1960@1|root,COG1960@2|Bacteria,2G65J@200795|Chloroflexi	200795|Chloroflexi	C	PFAM acyl-CoA dehydrogenase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
REGS1_k127_5770966_5	1382306.JNIM01000001_gene1486	5.705e-92	309.0	COG0412@1|root,COG0412@2|Bacteria	2|Bacteria	Q	carboxymethylenebutenolidase activity	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
REGS1_k127_5770966_8	485913.Krac_2132	9.226e-37	143.0	COG0251@1|root,COG0251@2|Bacteria	2|Bacteria	J	oxidation-reduction process	abmE	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
REGS1_k127_5770966_4	485913.Krac_2147	3.05e-99	331.0	COG1024@1|root,COG1024@2|Bacteria,2G6G6@200795|Chloroflexi	2|Bacteria	I	PFAM Enoyl-CoA hydratase isomerase	MA20_38145	-	-	-	-	-	-	-	-	-	-	-	ECH_1
REGS1_k127_5770966_6	485913.Krac_2148	1.504e-78	269.0	COG1028@1|root,COG1028@2|Bacteria,2G8CF@200795|Chloroflexi	200795|Chloroflexi	IQ	PFAM short-chain dehydrogenase reductase SDR	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
REGS1_k127_5770966_10	73044.JNXP01000007_gene5184	3.697e-23	115.0	COG3576@1|root,COG3576@2|Bacteria,2II3S@201174|Actinobacteria	201174|Actinobacteria	IQ	pyridoxamine 5-phosphate	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
REGS1_k127_5770966_3	1030157.AFMP01000058_gene1077	5.115e-100	346.0	COG0654@1|root,COG1902@1|root,COG0654@2|Bacteria,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,2TQPY@28211|Alphaproteobacteria,2K127@204457|Sphingomonadales	204457|Sphingomonadales	C	NADH flavin oxidoreductase NADH oxidase	-	-	1.14.13.40	ko:K09461	ko00627,ko01120,map00627,map01120	-	R03998,R03999	RC00244	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3,Oxidored_FMN
REGS1_k127_5770966_9	913865.DOT_6127	4.239e-30	128.0	2CIHT@1|root,2ZHS8@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Germane
REGS1_k127_5770966_0	926550.CLDAP_05900	8.738e-171	549.0	COG3844@1|root,COG3844@2|Bacteria,2G5K1@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively	kynU	-	3.7.1.3	ko:K01556	ko00380,ko01100,map00380,map01100	M00038	R00987,R02668,R03936	RC00284,RC00415	ko00000,ko00001,ko00002,ko01000	-	-	-	Aminotran_5
REGS1_k127_5770966_7	388051.AUFE01000005_gene1047	1.724e-46	168.0	COG3483@1|root,COG3483@2|Bacteria,1MW68@1224|Proteobacteria,2VJG3@28216|Betaproteobacteria,1K2UU@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety	kynA	GO:0003674,GO:0003824,GO:0004833,GO:0005488,GO:0006082,GO:0006139,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009063,GO:0009072,GO:0009074,GO:0009108,GO:0009117,GO:0009165,GO:0009308,GO:0009310,GO:0009435,GO:0009987,GO:0016043,GO:0016053,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019441,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0020037,GO:0022607,GO:0034641,GO:0034654,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043436,GO:0043648,GO:0043650,GO:0043933,GO:0044085,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046218,GO:0046394,GO:0046395,GO:0046483,GO:0046496,GO:0046700,GO:0046874,GO:0046906,GO:0048037,GO:0051186,GO:0051188,GO:0051213,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0055114,GO:0065003,GO:0070189,GO:0071704,GO:0071840,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606	1.13.11.11	ko:K00453	ko00380,ko01100,map00380,map01100	M00038	R00678	RC00356	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_dioxygenase
REGS1_k127_5772129_1	572547.Amico_0354	1.548e-65	233.0	COG0697@1|root,COG0697@2|Bacteria,3TB45@508458|Synergistetes	508458|Synergistetes	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
REGS1_k127_5772129_2	1382306.JNIM01000001_gene3404	1.132e-21	106.0	COG1432@1|root,COG1432@2|Bacteria	2|Bacteria	S	NYN domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN
REGS1_k127_5772129_0	335543.Sfum_2279	5.004e-71	252.0	COG1404@1|root,COG1404@2|Bacteria,1PFBD@1224|Proteobacteria,43A1G@68525|delta/epsilon subdivisions,2X9U2@28221|Deltaproteobacteria,2MSGE@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
REGS1_k127_5774256_0	926569.ANT_05360	2.913e-160	522.0	COG1243@1|root,COG1243@2|Bacteria,2G5ZZ@200795|Chloroflexi	200795|Chloroflexi	BK	Radical_SAM C-terminal domain	-	-	2.3.1.48	ko:K07739	-	-	-	-	ko00000,ko01000,ko03016,ko03036	-	-	-	Acetyltransf_1,Radical_SAM,Radical_SAM_C
REGS1_k127_5774256_4	357808.RoseRS_0674	5.06e-18	86.0	COG4634@1|root,COG4634@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_5774256_3	357808.RoseRS_0673	4.181e-29	117.0	COG2442@1|root,COG2442@2|Bacteria	2|Bacteria	K	InterPro IPR007367	-	-	-	-	-	-	-	-	-	-	-	-	DUF433
REGS1_k127_5774256_2	926550.CLDAP_10540	5.207e-41	160.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31
REGS1_k127_5774256_1	1423321.AS29_06225	4.39e-65	241.0	COG1820@1|root,COG1820@2|Bacteria,1TPFK@1239|Firmicutes,4HC6C@91061|Bacilli,1ZCM7@1386|Bacillus	91061|Bacilli	G	Belongs to the metallo-dependent hydrolases superfamily. NagA family	nagA	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005515,GO:0006040,GO:0006044,GO:0006046,GO:0008150,GO:0008152,GO:0008448,GO:0009056,GO:0016787,GO:0016810,GO:0016811,GO:0019213,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0046348,GO:0046872,GO:0046914,GO:0046983,GO:0071704,GO:1901071,GO:1901072,GO:1901135,GO:1901136,GO:1901575	3.5.1.25	ko:K01443	ko00520,ko01130,map00520,map01130	-	R02059	RC00166,RC00300	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
REGS1_k127_5774256_5	485913.Krac_4003	2.121e-11	76.0	2E4G6@1|root,335WF@2|Bacteria,2G9R2@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_5776784_2	867903.ThesuDRAFT_00388	3.962e-99	327.0	COG0479@1|root,COG0479@2|Bacteria,1TP17@1239|Firmicutes,24AN0@186801|Clostridia	186801|Clostridia	C	TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein	-	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_8
REGS1_k127_5776784_4	266117.Rxyl_2441	2.147e-12	69.0	2EP0Z@1|root,33GMU@2|Bacteria	2|Bacteria	K	Putative regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
REGS1_k127_5776784_0	867845.KI911784_gene1679	5.143e-150	496.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,2G69H@200795|Chloroflexi,37507@32061|Chloroflexia	32061|Chloroflexia	C	pyruvate flavodoxin ferredoxin oxidoreductase domain protein	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
REGS1_k127_5776784_3	1521187.JPIM01000004_gene3035	1.416e-95	321.0	COG1013@1|root,COG1013@2|Bacteria,2G679@200795|Chloroflexi,374ZH@32061|Chloroflexia	32061|Chloroflexia	C	PFAM thiamine pyrophosphate protein domain protein TPP-binding	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFO_beta_C,TPP_enzyme_C
REGS1_k127_5776784_1	751945.Theos_2092	4.858e-108	357.0	COG0320@1|root,COG0320@2|Bacteria,1WIE7@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
REGS1_k127_5786133_4	926560.KE387027_gene263	1.879e-24	113.0	COG2120@1|root,COG2120@2|Bacteria	2|Bacteria	S	N-acetylglucosaminylinositol deacetylase activity	-	-	-	ko:K22135	-	-	-	-	ko00000,ko01000	-	-	-	PIG-L
REGS1_k127_5786133_3	926569.ANT_22750	1.759e-42	162.0	2DMUR@1|root,32TTD@2|Bacteria,2G72Z@200795|Chloroflexi	200795|Chloroflexi	S	Domain of unknown function (DUF4395)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4395
REGS1_k127_5786133_5	926569.ANT_22740	1.378e-23	109.0	COG0526@1|root,COG0526@2|Bacteria,2G7HX@200795|Chloroflexi	200795|Chloroflexi	CO	COG0526, thiol-disulfide isomerase and thioredoxins	-	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
REGS1_k127_5786133_2	867903.ThesuDRAFT_00836	1.848e-104	351.0	COG0446@1|root,COG0446@2|Bacteria,1UC47@1239|Firmicutes,24NN7@186801|Clostridia	186801|Clostridia	S	PFAM Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
REGS1_k127_5786133_1	1128421.JAGA01000002_gene163	6.121e-125	409.0	COG1063@1|root,COG1063@2|Bacteria,2NPK3@2323|unclassified Bacteria	2|Bacteria	E	Zinc-binding dehydrogenase	tdh	-	1.1.1.103	ko:K00060	ko00260,map00260	-	R01465	RC00525	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
REGS1_k127_5786133_0	926569.ANT_30160	2.3e-187	592.0	COG0156@1|root,COG0156@2|Bacteria,2G65Q@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide	bioF	-	2.3.1.29	ko:K00639	ko00260,map00260	-	R00371	RC00004,RC00394	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
REGS1_k127_5786133_6	1304874.JAFY01000007_gene2257	3.243e-09	63.0	COG0648@1|root,COG0648@2|Bacteria,3TABZ@508458|Synergistetes	508458|Synergistetes	L	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin	nfo	-	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
REGS1_k127_5790936_9	485913.Krac_0209	2.726e-11	66.0	COG3293@1|root,COG3293@2|Bacteria,2G7ZQ@200795|Chloroflexi	200795|Chloroflexi	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_2,DUF4096
REGS1_k127_5790936_4	479434.Sthe_0904	3.456e-60	221.0	COG0438@1|root,COG0438@2|Bacteria,2G5PS@200795|Chloroflexi,27XVU@189775|Thermomicrobia	189775|Thermomicrobia	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
REGS1_k127_5790936_8	755731.Clo1100_2812	1.645e-11	75.0	COG0500@1|root,COG2226@2|Bacteria,1TR6N@1239|Firmicutes,2494W@186801|Clostridia,36UYJ@31979|Clostridiaceae	186801|Clostridia	Q	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
REGS1_k127_5790936_2	518766.Rmar_1133	7.204e-84	291.0	COG0451@1|root,COG0451@2|Bacteria,4NSF9@976|Bacteroidetes	976|Bacteroidetes	M	3-beta hydroxysteroid dehydrogenase/isomerase family	-	-	1.1.1.135	ko:K22252	ko00051,ko00520,map00051,map00520	-	R03396,R03398	RC00182	ko00000,ko00001,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
REGS1_k127_5790936_6	700508.D174_24375	7.544e-24	114.0	COG0438@1|root,COG0438@2|Bacteria,2GKEA@201174|Actinobacteria,232NK@1762|Mycobacteriaceae	201174|Actinobacteria	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
REGS1_k127_5790936_3	926550.CLDAP_16220	7.736e-84	292.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
REGS1_k127_5790936_0	926550.CLDAP_10380	1.994e-95	325.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	2.4.1.349	ko:K12994	-	-	-	-	ko00000,ko01000,ko01003,ko01005	-	GT4	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
REGS1_k127_5790936_1	316274.Haur_0234	7.558e-95	325.0	COG0438@1|root,COG0438@2|Bacteria,2G7TE@200795|Chloroflexi,3750Z@32061|Chloroflexia	32061|Chloroflexia	M	PFAM glycosyl transferase group 1	-	-	2.4.1.348	ko:K12995	-	-	-	-	ko00000,ko01000,ko01003,ko01005	-	GT4	-	Glyco_transf_4,Glycos_transf_1
REGS1_k127_5790936_5	244582.JQAK01000001_gene1815	4.165e-25	109.0	COG3293@1|root,COG3293@2|Bacteria,1MZS4@1224|Proteobacteria,2TXCF@28211|Alphaproteobacteria,47EZ1@766|Rickettsiales	766|Rickettsiales	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
REGS1_k127_5790936_7	321332.CYB_0197	2.905e-20	93.0	COG3293@1|root,COG3293@2|Bacteria,1G7GI@1117|Cyanobacteria,1H3PS@1129|Synechococcus	1117|Cyanobacteria	L	similarity to GB CAD86359.1	-	-	-	-	-	-	-	-	-	-	-	-	DUF4096
REGS1_k127_5795719_1	926569.ANT_22260	9.66e-57	201.0	COG1187@1|root,COG1187@2|Bacteria,2G6HU@200795|Chloroflexi	200795|Chloroflexi	J	Belongs to the pseudouridine synthase RsuA family	-	-	5.4.99.20,5.4.99.22	ko:K06178,ko:K06181	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
REGS1_k127_5795719_0	479434.Sthe_2647	8.744e-208	662.0	COG0143@1|root,COG0143@2|Bacteria,2G5ZU@200795|Chloroflexi,27XX7@189775|Thermomicrobia	189775|Thermomicrobia	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g
REGS1_k127_5802166_1	926550.CLDAP_30420	1.062e-89	317.0	COG5305@1|root,COG5305@2|Bacteria,2G7EE@200795|Chloroflexi	2|Bacteria	S	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	DUF2142,PMT_2
REGS1_k127_5802166_0	926550.CLDAP_12670	1.799e-105	360.0	COG3307@1|root,COG3307@2|Bacteria,2G6B1@200795|Chloroflexi	200795|Chloroflexi	M	PFAM O-antigen polymerase	-	-	-	-	-	-	-	-	-	-	-	-	Wzy_C
REGS1_k127_5802166_2	926550.CLDAP_21440	3.275e-77	286.0	COG4485@1|root,COG4485@2|Bacteria,2G75F@200795|Chloroflexi	200795|Chloroflexi	S	Bacterial membrane protein YfhO	-	-	-	-	-	-	-	-	-	-	-	-	YfhO
REGS1_k127_5802166_4	357808.RoseRS_1784	2.368e-06	58.0	COG5305@1|root,COG5305@2|Bacteria,2GAHI@200795|Chloroflexi,3765S@32061|Chloroflexia	32061|Chloroflexia	S	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_5802166_3	926550.CLDAP_21430	1.398e-19	100.0	COG5305@1|root,COG5305@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2142,PMT_2
REGS1_k127_5806638_0	1521187.JPIM01000020_gene209	3.014e-171	546.0	COG1003@1|root,COG1003@2|Bacteria,2G5MU@200795|Chloroflexi,374WQ@32061|Chloroflexia	32061|Chloroflexia	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPB	-	1.4.4.2	ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
REGS1_k127_5806638_2	1499967.BAYZ01000190_gene3859	2.08e-08	66.0	COG3227@1|root,COG4447@1|root,COG3227@2|Bacteria,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	2.7.11.1,3.4.24.25	ko:K08604,ko:K12132	ko05110,ko05111,map05110,map05111	-	-	-	ko00000,ko00001,ko01000,ko01001,ko01002	-	-	-	ChW,Cu_amine_oxidN1,F5_F8_type_C,Peptidase_M4,Peptidase_M4_C
REGS1_k127_5806638_1	525904.Tter_1189	5.889e-122	402.0	COG0372@1|root,COG0372@2|Bacteria,2NP9P@2323|unclassified Bacteria	2|Bacteria	C	Belongs to the citrate synthase family	citA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
REGS1_k127_5808119_0	273068.TTE1217	8.425e-229	720.0	COG1884@1|root,COG1884@2|Bacteria,1TQAD@1239|Firmicutes,24BDK@186801|Clostridia,42FIA@68295|Thermoanaerobacterales	186801|Clostridia	I	Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01847,ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
REGS1_k127_5808119_2	1289387.AUKW01000003_gene2582	1.551e-12	72.0	2DMB2@1|root,32UGJ@2|Bacteria,2IQ9P@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_5808119_1	76114.ebA246	1.253e-47	178.0	COG3335@1|root,COG3335@2|Bacteria,1P76X@1224|Proteobacteria,2VT62@28216|Betaproteobacteria	28216|Betaproteobacteria	L	ISFtu1 transposase K01152	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3
REGS1_k127_5808119_3	1101192.KB910516_gene4007	3.3e-07	57.0	COG3415@1|root,COG3415@2|Bacteria,1RM6K@1224|Proteobacteria,2UDU9@28211|Alphaproteobacteria,1JWCH@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_IS630
REGS1_k127_5808119_4	1173027.Mic7113_5357	5.097e-07	53.0	COG0563@1|root,COG0563@2|Bacteria,1G696@1117|Cyanobacteria,1HB35@1150|Oscillatoriales	1117|Cyanobacteria	F	Shikimate kinase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_18,PduV-EutP,SKI
REGS1_k127_5829825_3	118168.MC7420_8266	2.059e-30	123.0	2C4F2@1|root,331RG@2|Bacteria,1G9S1@1117|Cyanobacteria,1HDB3@1150|Oscillatoriales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_5829825_2	880073.Calab_3240	3.814e-43	165.0	COG0509@1|root,COG0509@2|Bacteria,2NPMR@2323|unclassified Bacteria	2|Bacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
REGS1_k127_5829825_0	1128421.JAGA01000002_gene784	2.582e-165	533.0	COG0403@1|root,COG0403@2|Bacteria,2NNP1@2323|unclassified Bacteria	2|Bacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPA	GO:0001505,GO:0003674,GO:0003824,GO:0004375,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005960,GO:0006082,GO:0006520,GO:0006544,GO:0006807,GO:0008150,GO:0008152,GO:0009069,GO:0009987,GO:0016491,GO:0016638,GO:0016642,GO:0017144,GO:0019752,GO:0032991,GO:0042133,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901605,GO:1902494,GO:1990204	1.4.4.2	ko:K00281,ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	GDC-P
REGS1_k127_5829825_1	1128421.JAGA01000002_gene785	4.233e-90	302.0	COG1003@1|root,COG1003@2|Bacteria,2NNSG@2323|unclassified Bacteria	2|Bacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPB	GO:0001505,GO:0003674,GO:0003824,GO:0004375,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005960,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016491,GO:0016638,GO:0016642,GO:0017144,GO:0019464,GO:0019752,GO:0032991,GO:0042133,GO:0042135,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1902494,GO:1990204	1.4.4.2	ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS11880	Aminotran_5,GDC-P
REGS1_k127_5832484_1	765420.OSCT_3224	8.106e-41	159.0	COG0726@1|root,COG0726@2|Bacteria,2G6VJ@200795|Chloroflexi	200795|Chloroflexi	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
REGS1_k127_5832484_0	1173024.KI912149_gene5493	7.657e-134	440.0	COG3408@1|root,COG3408@2|Bacteria,1G2AS@1117|Cyanobacteria,1JK2F@1189|Stigonemataceae	1117|Cyanobacteria	G	Glycogen debranching enzyme N terminal	-	-	-	-	-	-	-	-	-	-	-	-	GDE_C,GDE_N
REGS1_k127_5847798_3	926550.CLDAP_16820	1.192e-11	70.0	COG0789@1|root,COG0789@2|Bacteria	2|Bacteria	K	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding	-	-	3.1.21.3,5.4.99.60,5.4.99.61	ko:K01153,ko:K06042,ko:K22491	ko00860,ko01100,map00860,map01100	-	R05177,R05814	RC01292,RC01980	ko00000,ko00001,ko01000,ko02048,ko03000	-	-	-	B12-binding,B12-binding_2,EcoEI_R_C,HTH_17,Helicase_C,MerR_1,ResIII
REGS1_k127_5847798_1	1382356.JQMP01000004_gene227	1.974e-69	237.0	COG2080@1|root,COG2080@2|Bacteria,2G6NT@200795|Chloroflexi,27XMB@189775|Thermomicrobia	189775|Thermomicrobia	C	[2Fe-2S] binding domain	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
REGS1_k127_5847798_0	357808.RoseRS_0341	0.0	1106.0	COG1529@1|root,COG1529@2|Bacteria,2G608@200795|Chloroflexi,376SU@32061|Chloroflexia	32061|Chloroflexia	C	PFAM aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
REGS1_k127_5847798_2	1122221.JHVI01000005_gene595	4.745e-61	216.0	COG1319@1|root,COG1319@2|Bacteria,1WKW7@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	CO dehydrogenase flavoprotein C-terminal domain	-	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
REGS1_k127_5852453_2	926550.CLDAP_04120	3.877e-80	269.0	COG0050@1|root,COG0050@2|Bacteria,2G5KI@200795|Chloroflexi	200795|Chloroflexi	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
REGS1_k127_5852453_7	525904.Tter_1826	2.456e-16	79.0	COG0267@1|root,COG0267@2|Bacteria,2NQ3R@2323|unclassified Bacteria	2|Bacteria	J	Ribosomal protein L33	rpmG	-	-	ko:K02913	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L33
REGS1_k127_5852453_8	1128421.JAGA01000002_gene1607	3.92e-11	66.0	COG0690@1|root,COG0690@2|Bacteria	2|Bacteria	U	P-P-bond-hydrolysis-driven protein transmembrane transporter activity	secE	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecE
REGS1_k127_5852453_3	926569.ANT_18990	1.117e-64	229.0	COG0250@1|root,COG0250@2|Bacteria,2G6A3@200795|Chloroflexi	200795|Chloroflexi	K	Participates in transcription elongation, termination and antitermination	nusG	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,NusG
REGS1_k127_5852453_4	555079.Toce_2103	9.422e-63	220.0	COG0080@1|root,COG0080@2|Bacteria,1V1BS@1239|Firmicutes,24FSQ@186801|Clostridia,42G61@68295|Thermoanaerobacterales	186801|Clostridia	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rplK	-	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
REGS1_k127_5852453_1	926550.CLDAP_14840	1.222e-85	292.0	COG0081@1|root,COG0081@2|Bacteria,2G6AW@200795|Chloroflexi	200795|Chloroflexi	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
REGS1_k127_5852453_6	1303518.CCALI_02655	1.198e-30	127.0	COG0244@1|root,COG0244@2|Bacteria	2|Bacteria	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rplJ	GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0017148,GO:0019222,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113	-	ko:K02864,ko:K02935	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
REGS1_k127_5852453_5	938288.HG326225_gene1061	3.62e-35	141.0	COG0222@1|root,COG0222@2|Bacteria,1V6EI@1239|Firmicutes,24JAC@186801|Clostridia,269AI@186813|unclassified Clostridiales	186801|Clostridia	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation	rplL	-	-	ko:K02935	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L12,Ribosomal_L12_N
REGS1_k127_5852453_9	1205683.CAKR01000025_gene3679	1.035e-05	48.0	2DT3B@1|root,33IHT@2|Bacteria,1NK4F@1224|Proteobacteria,1SHSY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_5852453_0	926569.ANT_10660	1.5e-157	507.0	COG0495@1|root,COG0495@2|Bacteria,2G5MX@200795|Chloroflexi	200795|Chloroflexi	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
REGS1_k127_585422_0	357808.RoseRS_1778	7.24e-146	476.0	COG0477@1|root,COG2814@2|Bacteria,2G68C@200795|Chloroflexi,3781C@32061|Chloroflexia	32061|Chloroflexia	EGP	major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
REGS1_k127_585422_3	1120973.AQXL01000122_gene144	2.106e-75	261.0	COG3327@1|root,COG3327@2|Bacteria,1TRBU@1239|Firmicutes,4HCP9@91061|Bacilli,278XH@186823|Alicyclobacillaceae	91061|Bacilli	K	PaaX-like protein	paaX	-	-	ko:K02616	-	-	-	-	ko00000,ko03000	-	-	-	PaaX,PaaX_C
REGS1_k127_585422_1	1379698.RBG1_1C00001G0907	9.642e-136	439.0	COG1024@1|root,COG1024@2|Bacteria	2|Bacteria	I	Enoyl-CoA hydratase	bamA	GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009150,GO:0009154,GO:0009166,GO:0009259,GO:0009261,GO:0009987,GO:0016787,GO:0016822,GO:0016823,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0033865,GO:0033869,GO:0033875,GO:0034031,GO:0034032,GO:0034034,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035383,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044273,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901787,GO:1901788	3.7.1.21	ko:K07539,ko:K18570	ko00332,ko00362,ko01100,ko01120,ko01130,ko01220,map00332,map00362,map01100,map01120,map01130,map01220	M00541	R05593,R05594,R10696,R10750	RC01430,RC01431,RC03237,RC03270	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
REGS1_k127_585422_4	1234664.AMRO01000011_gene2620	9.078e-72	253.0	COG0491@1|root,COG0491@2|Bacteria,1TQPX@1239|Firmicutes,4HAV6@91061|Bacilli,1WFUV@129337|Geobacillus	91061|Bacilli	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
REGS1_k127_585422_5	1125863.JAFN01000001_gene2446	4.041e-70	246.0	COG1024@1|root,COG1024@2|Bacteria,1R7WW@1224|Proteobacteria,42NZQ@68525|delta/epsilon subdivisions,2WMCW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.100	ko:K07537	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R05597	RC03168	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
REGS1_k127_585422_7	643473.KB235930_gene819	2.328e-29	124.0	COG0515@1|root,COG3899@1|root,COG4191@1|root,COG0515@2|Bacteria,COG3899@2|Bacteria,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GAF,GAF_2,GGDEF,HATPase_c,HisKA,PAS_3,PAS_9,Pkinase
REGS1_k127_585422_2	398767.Glov_2401	6.165e-109	364.0	COG1775@1|root,COG1775@2|Bacteria,1NNW9@1224|Proteobacteria,42RTN@68525|delta/epsilon subdivisions,2WNYI@28221|Deltaproteobacteria,43V0Q@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	2-hydroxyglutaryl-CoA dehydratase, D-component	-	-	1.3.7.8	ko:K04112	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R02451	RC00002,RC01839	ko00000,ko00001,ko00002,ko01000	-	-	-	HGD-D
REGS1_k127_585422_6	398767.Glov_2400	2.654e-38	149.0	COG1775@1|root,COG1775@2|Bacteria,1NKED@1224|Proteobacteria,430HE@68525|delta/epsilon subdivisions,2WVZI@28221|Deltaproteobacteria,43V4N@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	2-hydroxyglutaryl-CoA dehydratase, D-component	-	-	1.3.7.8	ko:K04113	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R02451	RC00002,RC01839	ko00000,ko00001,ko00002,ko01000	-	-	-	HGD-D
REGS1_k127_5856110_2	926569.ANT_09260	1.561e-30	123.0	COG0745@1|root,COG0745@2|Bacteria,2G6JP@200795|Chloroflexi	200795|Chloroflexi	K	COGs COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	ko:K07667	ko02020,ko02024,map02020,map02024	M00454	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
REGS1_k127_5856110_0	398767.Glov_3227	6.313e-308	968.0	COG0642@1|root,COG2205@2|Bacteria,1MUZQ@1224|Proteobacteria,42NZF@68525|delta/epsilon subdivisions,2WJNR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase	kdpD	-	2.7.13.3	ko:K07646	ko02020,map02020	M00454	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF4118,GAF_3,HATPase_c,HisKA,KdpD,Usp
REGS1_k127_5856110_1	243233.MCA2215	6.763e-76	258.0	COG2156@1|root,COG2156@2|Bacteria,1RABG@1224|Proteobacteria,1S2B0@1236|Gammaproteobacteria,1XF8W@135618|Methylococcales	135618|Methylococcales	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex	kdpC	-	3.6.3.12	ko:K01548	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	-	KdpC
REGS1_k127_5858213_2	1206744.BAGL01000033_gene220	2.637e-115	378.0	COG1788@1|root,COG1788@2|Bacteria,2I9F6@201174|Actinobacteria,4FZB8@85025|Nocardiaceae	201174|Actinobacteria	I	Coenzyme A transferase	catI	-	2.8.3.12	ko:K01039	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
REGS1_k127_5858213_7	1173022.Cri9333_2871	7.165e-06	57.0	COG0515@1|root,COG0515@2|Bacteria,1FZWQ@1117|Cyanobacteria,1H9JY@1150|Oscillatoriales	1117|Cyanobacteria	T	PFAM Protein kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
REGS1_k127_5858213_5	706587.Desti_1291	3.145e-55	205.0	COG0483@1|root,COG0483@2|Bacteria,1MUQT@1224|Proteobacteria,42R1W@68525|delta/epsilon subdivisions,2WMQ4@28221|Deltaproteobacteria,2MR8P@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	PFAM inositol monophosphatase	suhB	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
REGS1_k127_5858213_6	77635.BISU_0066	5.217e-07	62.0	COG1653@1|root,COG1653@2|Bacteria,2GNYN@201174|Actinobacteria,4D08X@85004|Bifidobacteriales	201174|Actinobacteria	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027,ko:K17329	ko02010,map02010	M00207,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.33	-	-	SBP_bac_1,SBP_bac_8
REGS1_k127_5858213_0	997346.HMPREF9374_0894	1.539e-139	456.0	COG0304@1|root,COG0304@2|Bacteria,1TPA7@1239|Firmicutes,4H9SD@91061|Bacilli,27B4D@186824|Thermoactinomycetaceae	91061|Bacilli	IQ	Beta-ketoacyl synthase, C-terminal domain	fabF3	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
REGS1_k127_5858213_1	926550.CLDAP_06710	5.808e-135	439.0	COG0332@1|root,COG0332@2|Bacteria,2G630@200795|Chloroflexi	200795|Chloroflexi	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
REGS1_k127_5858213_4	1499967.BAYZ01000009_gene5328	5.638e-65	250.0	COG1971@1|root,COG1971@2|Bacteria	2|Bacteria	P	manganese ion transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	Mntp
REGS1_k127_5858213_3	326427.Cagg_3120	1.763e-68	247.0	COG0665@1|root,COG0665@2|Bacteria,2G6HT@200795|Chloroflexi,374X0@32061|Chloroflexia	32061|Chloroflexia	E	FAD dependent oxidoreductase	-	-	1.5.3.1	ko:K00303	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO
REGS1_k127_5881718_1	926550.CLDAP_04640	5.194e-116	382.0	COG0402@1|root,COG0402@2|Bacteria,2G7M9@200795|Chloroflexi	200795|Chloroflexi	F	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
REGS1_k127_5881718_8	406124.ACPC01000049_gene37	3.855e-09	68.0	COG0454@1|root,COG0456@2|Bacteria,1UZC5@1239|Firmicutes,4HFDR@91061|Bacilli,1ZE2E@1386|Bacillus	91061|Bacilli	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_6
REGS1_k127_5881718_5	1144307.PMI04_01153	9.195e-46	174.0	COG2085@1|root,COG2085@2|Bacteria,1MXS0@1224|Proteobacteria,2TS1W@28211|Alphaproteobacteria,2K27G@204457|Sphingomonadales	204457|Sphingomonadales	S	NADP oxidoreductase coenzyme F420-dependent	-	-	1.5.1.40	ko:K06988	-	-	-	-	ko00000,ko01000	-	-	-	F420_oxidored
REGS1_k127_5881718_3	1187851.A33M_3616	4.354e-72	251.0	COG1478@1|root,COG1478@2|Bacteria,1PQHN@1224|Proteobacteria,2TU1P@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	F420-0 Gamma-glutamyl ligase	cofE	-	6.3.2.31,6.3.2.34	ko:K12234	ko00680,ko01120,map00680,map01120	M00378	R09399,R09400	RC00064,RC00090,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_ligase
REGS1_k127_5881718_4	926550.CLDAP_12770	9.698e-61	216.0	COG0778@1|root,COG0778@2|Bacteria,2G693@200795|Chloroflexi	200795|Chloroflexi	C	PFAM Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
REGS1_k127_5881718_2	266117.Rxyl_0958	4.435e-101	338.0	COG0391@1|root,COG0391@2|Bacteria,2GJZ2@201174|Actinobacteria,4CPHB@84995|Rubrobacteria	84995|Rubrobacteria	S	Uncharacterised protein family UPF0052	-	-	2.7.8.28	ko:K11212	ko00680,ko01120,map00680,map01120	M00378	R09398	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	UPF0052
REGS1_k127_5881718_6	316058.RPB_4422	1.657e-15	84.0	COG1920@1|root,COG1920@2|Bacteria,1RJPN@1224|Proteobacteria,2UAA7@28211|Alphaproteobacteria,3K03I@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor	cofC	-	2.7.7.68	ko:K14941	ko00680,ko01120,map00680,map01120	M00378	R09397	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CofC
REGS1_k127_5881718_0	926569.ANT_14450	4.71e-171	542.0	COG2141@1|root,COG2141@2|Bacteria,2G727@200795|Chloroflexi	200795|Chloroflexi	C	Luciferase-like monooxygenase	-	-	1.5.98.2	ko:K00320	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R04464	RC01607	ko00000,ko00001,ko00002,ko01000	-	-	-	Bac_luciferase
REGS1_k127_5881718_7	935840.JAEQ01000019_gene2104	4.792e-13	79.0	COG1319@1|root,COG1319@2|Bacteria,1RCRH@1224|Proteobacteria,2TU08@28211|Alphaproteobacteria,43PT0@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM	xdhB	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
REGS1_k127_5901129_1	525904.Tter_1681	2.2e-28	118.0	COG2843@1|root,COG3103@1|root,COG2843@2|Bacteria,COG4991@2|Bacteria,2NPJI@2323|unclassified Bacteria	2|Bacteria	M	Bacterial capsule synthesis protein PGA_cap	-	-	2.7.11.1	ko:K07282,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PGA_cap,SH3_3,SH3_4
REGS1_k127_5901631_0	926550.CLDAP_27640	1.284e-78	267.0	COG0745@1|root,COG0745@2|Bacteria,2G8CC@200795|Chloroflexi	200795|Chloroflexi	K	Transcriptional regulatory protein, C terminal	-	-	-	ko:K07658	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
REGS1_k127_5901631_1	926569.ANT_22650	1.274e-27	124.0	COG0642@1|root,COG2205@2|Bacteria,2GBIY@200795|Chloroflexi	200795|Chloroflexi	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
REGS1_k127_5906266_0	926550.CLDAP_30370	3.559e-103	358.0	COG3391@1|root,COG4745@1|root,COG3391@2|Bacteria,COG4745@2|Bacteria,2G5PE@200795|Chloroflexi	200795|Chloroflexi	O	PFAM NHL repeat containing protein	-	-	-	-	-	-	-	-	-	-	-	-	NHL,PMT_2
REGS1_k127_591884_0	926569.ANT_14490	6.191e-149	484.0	COG1319@1|root,COG2080@1|root,COG1319@2|Bacteria,COG2080@2|Bacteria,2G5XD@200795|Chloroflexi	200795|Chloroflexi	C	CO dehydrogenase flavoprotein C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	CO_deh_flav_C,FAD_binding_5,Fer2,Fer2_2
REGS1_k127_591884_1	926569.ANT_14480	8.251e-75	259.0	COG1975@1|root,COG1975@2|Bacteria,2G6H0@200795|Chloroflexi	200795|Chloroflexi	O	XdhC Rossmann domain	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI
REGS1_k127_591884_2	1408224.SAMCCGM7_c6014	3.195e-37	144.0	COG3189@1|root,COG3189@2|Bacteria,1MZ7H@1224|Proteobacteria,2UCUJ@28211|Alphaproteobacteria,4BG26@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function, DUF488	-	-	-	-	-	-	-	-	-	-	-	-	DUF488
REGS1_k127_5922329_1	926550.CLDAP_00150	1.738e-97	343.0	COG0664@1|root,COG0664@2|Bacteria,2G902@200795|Chloroflexi	200795|Chloroflexi	C	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_6,Fer4_7,cNMP_binding
REGS1_k127_5922329_2	357808.RoseRS_4389	3.956e-60	214.0	COG1595@1|root,COG1595@2|Bacteria,2G6MG@200795|Chloroflexi,375K5@32061|Chloroflexia	32061|Chloroflexia	K	PFAM sigma-70 region 2 domain protein	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
REGS1_k127_5922329_8	1122921.KB898185_gene4125	0.0006635	51.0	COG0726@1|root,COG1705@1|root,COG0726@2|Bacteria,COG1705@2|Bacteria	2|Bacteria	NU	amidase activity	pgdA	GO:0005575,GO:0016020	3.4.21.66,3.5.1.104,3.5.1.28	ko:K01448,ko:K02395,ko:K08651,ko:K17733,ko:K22278	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko02035,ko03036,ko03110	-	-	-	Glucosaminidase,Polysacc_deac_1
REGS1_k127_5922329_4	926569.ANT_03760	1.969e-42	160.0	COG2018@1|root,COG2018@2|Bacteria,2G8WW@200795|Chloroflexi	200795|Chloroflexi	S	PFAM Roadblock LC7 family protein	-	-	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
REGS1_k127_5922329_0	1128421.JAGA01000002_gene468	1.577e-238	747.0	COG0504@1|root,COG0504@2|Bacteria,2NNVG@2323|unclassified Bacteria	2|Bacteria	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	GO:0001775,GO:0002376,GO:0003674,GO:0003824,GO:0003883,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006241,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008283,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009208,GO:0009209,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016020,GO:0016874,GO:0016879,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032943,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042098,GO:0042100,GO:0042110,GO:0042113,GO:0042221,GO:0042455,GO:0042493,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045321,GO:0046036,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046649,GO:0046651,GO:0050896,GO:0055086,GO:0070661,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1276,iECO103_1326.ECO103_3323,iHN637.CLJU_RS01075,iNJ661.Rv1699,iPC815.YPO3377	CTP_synth_N,GATase
REGS1_k127_5922329_3	926569.ANT_09820	2.34e-57	224.0	COG2199@1|root,COG2203@1|root,COG2203@2|Bacteria,COG3706@2|Bacteria,2G97C@200795|Chloroflexi	200795|Chloroflexi	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Response_reg
REGS1_k127_5922329_5	1200352.A606_04085	1.204e-25	106.0	COG1250@1|root,COG1250@2|Bacteria,2GJBM@201174|Actinobacteria,22JXM@1653|Corynebacteriaceae	201174|Actinobacteria	I	3-hydroxyacyl-CoA dehydrogenase	fadB2	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006635,GO:0008150,GO:0008152,GO:0008610,GO:0008691,GO:0009056,GO:0009058,GO:0009062,GO:0009605,GO:0009607,GO:0009987,GO:0016020,GO:0016042,GO:0016053,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0019395,GO:0019752,GO:0030258,GO:0030312,GO:0030497,GO:0032787,GO:0034440,GO:0043207,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044249,GO:0044255,GO:0044281,GO:0044282,GO:0044283,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046395,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0055114,GO:0071704,GO:0071944,GO:0072329,GO:0072330,GO:0075136,GO:1901575,GO:1901576	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	iNJ661.Rv0468	3HCDH,3HCDH_N
REGS1_k127_5932447_1	1267535.KB906767_gene2871	4.371e-280	879.0	COG0474@1|root,COG0474@2|Bacteria,3Y3ZX@57723|Acidobacteria,2JMFS@204432|Acidobacteriia	204432|Acidobacteriia	P	TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.2	ko:K01531	-	-	-	-	ko00000,ko01000	3.A.3.4	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
REGS1_k127_5932447_0	103690.17130114	0.0	1284.0	COG0045@1|root,COG1042@1|root,COG1670@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG1670@2|Bacteria,1G2D3@1117|Cyanobacteria,1HIIK@1161|Nostocales	1117|Cyanobacteria	CJ	TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain	-	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
REGS1_k127_5932447_2	867845.KI911784_gene1	1.38e-120	394.0	COG0593@1|root,COG0593@2|Bacteria,2G5W8@200795|Chloroflexi,3759K@32061|Chloroflexia	32061|Chloroflexia	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
REGS1_k127_6004660_3	926550.CLDAP_32530	5.373e-24	108.0	COG3576@1|root,COG3576@2|Bacteria,2GA9W@200795|Chloroflexi	200795|Chloroflexi	S	Pfam:Pyridox_oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
REGS1_k127_6004660_0	926550.CLDAP_25810	6.688e-141	457.0	COG0674@1|root,COG0674@2|Bacteria,2G5UG@200795|Chloroflexi	200795|Chloroflexi	C	Pyruvate:ferredoxin oxidoreductase core domain II	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
REGS1_k127_6004660_4	357808.RoseRS_1371	3.607e-21	95.0	COG1146@1|root,COG1146@2|Bacteria,2G7ES@200795|Chloroflexi	200795|Chloroflexi	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	1.2.7.3	ko:K00176	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4
REGS1_k127_6004660_2	479434.Sthe_0662	1.084e-64	229.0	COG0463@1|root,COG1216@1|root,COG0463@2|Bacteria,COG1216@2|Bacteria,2G6JZ@200795|Chloroflexi,27XJJ@189775|Thermomicrobia	189775|Thermomicrobia	M	Glycosyl transferase family group 2	-	-	-	ko:K07011	-	-	-	-	ko00000	-	-	-	Glycos_transf_2
REGS1_k127_6004660_1	525904.Tter_0018	1.25e-80	280.0	COG1940@1|root,COG1940@2|Bacteria,2NPRP@2323|unclassified Bacteria	2|Bacteria	GK	ROK family	glcK	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS10220	ROK
REGS1_k127_6019857_3	2002.JOEQ01000025_gene241	3.969e-76	264.0	COG1680@1|root,COG1680@2|Bacteria,2I9GC@201174|Actinobacteria,4EH2G@85012|Streptosporangiales	201174|Actinobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
REGS1_k127_6019857_4	2002.JOEQ01000025_gene241	1.257e-36	141.0	COG1680@1|root,COG1680@2|Bacteria,2I9GC@201174|Actinobacteria,4EH2G@85012|Streptosporangiales	201174|Actinobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
REGS1_k127_6019857_2	937777.Deipe_1309	3.195e-141	453.0	COG1082@1|root,COG1082@2|Bacteria,1WJN9@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	PFAM Xylose isomerase-like TIM barrel	-	-	4.2.1.44	ko:K03335	ko00562,ko01100,ko01120,map00562,map01100,map01120	-	R02782,R05659	RC00782,RC01448	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
REGS1_k127_6019857_0	234267.Acid_1483	7.444e-265	828.0	COG3962@1|root,COG3962@2|Bacteria	2|Bacteria	E	Belongs to the TPP enzyme family	iolD	GO:0006629,GO:0006644,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009056,GO:0009395,GO:0009987,GO:0016042,GO:0019637,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0046434,GO:0071704,GO:1901575	3.7.1.22	ko:K03336	ko00562,ko01100,ko01120,map00562,map01100,map01120	-	R08603	RC02331	ko00000,ko00001,ko01000	-	-	iYO844.BSU39730	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
REGS1_k127_6019857_1	926550.CLDAP_26270	1.647e-146	473.0	COG0176@1|root,COG0176@2|Bacteria	2|Bacteria	G	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
REGS1_k127_6027448_1	225849.swp_0164	0.0007961	48.0	COG1470@1|root,COG3391@1|root,COG1470@2|Bacteria,COG3391@2|Bacteria,1QXEX@1224|Proteobacteria,1T39Y@1236|Gammaproteobacteria,2QAPE@267890|Shewanellaceae	1236|Gammaproteobacteria	S	Calx-beta domain	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta,CarboxypepD_reg
REGS1_k127_6027448_0	1128421.JAGA01000002_gene165	3.188e-104	345.0	COG2896@1|root,COG2896@2|Bacteria,2NP5R@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016020,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0030312,GO:0040007,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0071704,GO:0071944,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.99.22,4.6.1.17	ko:K03639,ko:K20967	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394,R11372	RC03420,RC03425	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM
REGS1_k127_6029631_1	1894.JOER01000003_gene2832	2.781e-21	100.0	29CFH@1|root,2ZZDX@2|Bacteria,2IN9J@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_6029631_0	324602.Caur_2704	6.563e-38	151.0	COG1597@1|root,COG1597@2|Bacteria,2G6UK@200795|Chloroflexi,375KA@32061|Chloroflexia	32061|Chloroflexia	I	PFAM diacylglycerol kinase catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
REGS1_k127_6034690_5	189426.PODO_11590	3.187e-32	132.0	COG0451@1|root,COG0451@2|Bacteria	2|Bacteria	GM	ADP-glyceromanno-heptose 6-epimerase activity	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
REGS1_k127_6034690_4	1499967.BAYZ01000041_gene2334	6.329e-36	145.0	COG0491@1|root,COG0491@2|Bacteria	2|Bacteria	GM	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	VVA1313	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
REGS1_k127_6034690_7	479434.Sthe_2459	2.624e-07	57.0	2DRD4@1|root,33B9X@2|Bacteria,2G7IX@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_6034690_0	1120973.AQXL01000125_gene3124	8.389e-107	359.0	COG0577@1|root,COG0577@2|Bacteria,1TPUU@1239|Firmicutes,4HATE@91061|Bacilli,2795F@186823|Alicyclobacillaceae	91061|Bacilli	V	MacB-like periplasmic core domain	macB1	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
REGS1_k127_6034690_3	357808.RoseRS_4067	1.873e-48	190.0	COG0845@1|root,COG0845@2|Bacteria,2G6RK@200795|Chloroflexi,376DC@32061|Chloroflexia	32061|Chloroflexia	MV	TIGRFAM efflux transporter, RND family, MFP subunit	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_D23
REGS1_k127_6034690_6	1236902.ANAS01000004_gene3434	1.736e-09	66.0	COG1846@1|root,COG1846@2|Bacteria,2IMUX@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
REGS1_k127_6034690_2	671143.DAMO_1522	2.178e-58	211.0	COG2267@1|root,COG2267@2|Bacteria,2NPTF@2323|unclassified Bacteria	2|Bacteria	I	Alpha/beta hydrolase family	mhpC	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4,Abhydrolase_6
REGS1_k127_6034690_1	357808.RoseRS_0097	3.918e-84	284.0	COG0492@1|root,COG0492@2|Bacteria,2G5Z5@200795|Chloroflexi,376IE@32061|Chloroflexia	32061|Chloroflexia	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
REGS1_k127_6038416_1	555088.DealDRAFT_2005	7.522e-99	334.0	COG1363@1|root,COG1363@2|Bacteria,1TNZT@1239|Firmicutes,24BAN@186801|Clostridia	186801|Clostridia	G	M42 glutamyl aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M42
REGS1_k127_6038416_2	1173024.KI912152_gene398	1.294e-55	202.0	COG3393@1|root,COG3393@2|Bacteria,1GF6E@1117|Cyanobacteria	1117|Cyanobacteria	S	-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_7
REGS1_k127_6038416_0	255470.cbdbA1196	4.172e-129	425.0	COG0018@1|root,COG0018@2|Bacteria,2G6DK@200795|Chloroflexi,34CN0@301297|Dehalococcoidia	301297|Dehalococcoidia	J	arginyl-tRNA aminoacylation	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
REGS1_k127_6048603_1	644966.Tmar_2076	9.826e-91	311.0	COG0037@1|root,COG0037@2|Bacteria,1UB13@1239|Firmicutes,249NH@186801|Clostridia	186801|Clostridia	H	Belongs to the TtcA family	-	-	2.8.1.15	ko:K21947	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3
REGS1_k127_6048603_0	765420.OSCT_2291	1.182e-109	373.0	COG0728@1|root,COG0728@2|Bacteria,2G5PF@200795|Chloroflexi,374ZA@32061|Chloroflexia	32061|Chloroflexia	S	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	-	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
REGS1_k127_60775_3	192952.MM_3243	1.129e-20	104.0	arCOG06746@1|root,arCOG06746@2157|Archaea,2Y5GC@28890|Euryarchaeota	28890|Euryarchaeota	S	Pfam:DUF422	-	-	-	-	-	-	-	-	-	-	-	-	Caroten_synth
REGS1_k127_60775_1	525904.Tter_0600	2.764e-33	129.0	COG1146@1|root,COG1146@2|Bacteria,2NPWS@2323|unclassified Bacteria	2|Bacteria	C	4Fe-4S binding domain	fdxA	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_4,Fer4_7
REGS1_k127_60775_0	1303518.CCALI_01253	1.517e-70	251.0	COG0526@1|root,COG0526@2|Bacteria	2|Bacteria	CO	cell redox homeostasis	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin,Thioredoxin
REGS1_k127_60775_2	756272.Plabr_4336	6.602e-27	113.0	COG0614@1|root,COG0614@2|Bacteria,2J06G@203682|Planctomycetes	203682|Planctomycetes	P	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_3
REGS1_k127_6115981_1	1499967.BAYZ01000176_gene5652	3.446e-95	323.0	COG0451@1|root,COG0451@2|Bacteria,2NNT0@2323|unclassified Bacteria	2|Bacteria	M	Polysaccharide biosynthesis protein	ytcB	-	5.1.3.2,5.1.3.6	ko:K01784,ko:K08679	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R01385,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
REGS1_k127_6115981_5	485913.Krac_7145	4.527e-75	263.0	COG0330@1|root,COG0330@2|Bacteria	2|Bacteria	O	stress-induced mitochondrial fusion	cnpD	-	-	-	-	-	-	-	-	-	-	-	Band_7
REGS1_k127_6115981_0	485913.Krac_7146	1.567e-106	353.0	COG0061@1|root,COG0061@2|Bacteria	2|Bacteria	H	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
REGS1_k127_6115981_4	479434.Sthe_3321	7.478e-78	275.0	COG1134@1|root,COG1134@2|Bacteria,2G6D9@200795|Chloroflexi	200795|Chloroflexi	GM	PFAM ABC transporter related	-	-	-	ko:K09691	ko02010,map02010	M00250	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.103	-	-	ABC_tran,Wzt_C
REGS1_k127_6115981_6	290340.AAur_3131	7.348e-15	87.0	COG2327@1|root,COG2327@2|Bacteria,2IR3S@201174|Actinobacteria,1WBFF@1268|Micrococcaceae	201174|Actinobacteria	S	Polysaccharide pyruvyl transferase	-	-	-	ko:K16710	-	-	-	-	ko00000	-	-	-	PS_pyruv_trans
REGS1_k127_6115981_7	1121405.dsmv_2611	1.215e-11	77.0	COG0603@1|root,COG1402@1|root,COG0603@2|Bacteria,COG1402@2|Bacteria,1MXR9@1224|Proteobacteria,42QNA@68525|delta/epsilon subdivisions,2X9RQ@28221|Deltaproteobacteria,2MPA0@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Creatinine amidohydrolase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
REGS1_k127_6115981_10	1121904.ARBP01000003_gene6367	3.095e-08	66.0	COG0603@1|root,COG1402@1|root,COG0603@2|Bacteria,COG1402@2|Bacteria,4NF2C@976|Bacteroidetes,47S41@768503|Cytophagia	976|Bacteroidetes	F	Creatinine amidohydrolase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
REGS1_k127_6115981_11	374847.Kcr_0356	0.0001045	55.0	arCOG05346@1|root,arCOG05346@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_6115981_8	1122176.KB903554_gene3815	1.272e-08	67.0	COG0603@1|root,COG0603@2|Bacteria,4NM2T@976|Bacteroidetes	976|Bacteroidetes	F	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_6115981_12	263820.PTO0562	0.0001325	54.0	arCOG05346@1|root,arCOG05346@2157|Archaea,2XWG1@28890|Euryarchaeota,241ZP@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_6115981_2	383372.Rcas_2261	4.058e-89	310.0	COG0438@1|root,COG0438@2|Bacteria,2G82G@200795|Chloroflexi,375AN@32061|Chloroflexia	32061|Chloroflexia	M	PFAM glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4,Glycos_transf_1
REGS1_k127_6115981_3	316274.Haur_2957	5.323e-83	288.0	COG0438@1|root,COG0438@2|Bacteria,2G82G@200795|Chloroflexi,375AN@32061|Chloroflexia	32061|Chloroflexia	M	PFAM glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4,Glycos_transf_1
REGS1_k127_6151106_0	2325.TKV_c14280	4.906e-76	268.0	COG2270@1|root,COG2270@2|Bacteria,1UHZ6@1239|Firmicutes,25E7U@186801|Clostridia,42FVR@68295|Thermoanaerobacterales	186801|Clostridia	S	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
REGS1_k127_6151106_1	926550.CLDAP_35470	4.879e-62	236.0	COG3103@1|root,COG3858@1|root,COG3858@2|Bacteria,COG4991@2|Bacteria	2|Bacteria	T	sh3 domain protein	MA20_15015	-	-	-	-	-	-	-	-	-	-	-	DUF1236,SH3_3
REGS1_k127_6156828_2	485913.Krac_8263	2.813e-66	232.0	COG0626@1|root,COG0626@2|Bacteria,2G5M2@200795|Chloroflexi	200795|Chloroflexi	E	PFAM Cys Met metabolism pyridoxal-phosphate-dependent protein	-	-	2.5.1.48,4.4.1.11	ko:K01739,ko:K01761	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00654,R00999,R01288,R02508,R03217,R03260,R04770,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00196,RC00348,RC00420,RC01209,RC01210,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
REGS1_k127_6156828_0	479434.Sthe_2024	4.027e-167	537.0	COG0031@1|root,COG3620@1|root,COG0031@2|Bacteria,COG3620@2|Bacteria,2G698@200795|Chloroflexi,27YAJ@189775|Thermomicrobia	189775|Thermomicrobia	E	Cysteine synthase	-	-	2.5.1.47,4.2.1.22	ko:K01697,ko:K01738,ko:K12339	ko00260,ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021,M00035,M00338	R00891,R00897,R01290,R03132,R03601,R04859,R04942	RC00020,RC00056,RC00069,RC00256,RC00489,RC01246,RC02814,RC02821,RC02876	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
REGS1_k127_6156828_1	338969.Rfer_0358	1.165e-158	509.0	COG0477@1|root,COG2814@2|Bacteria,1NE49@1224|Proteobacteria,2VNGV@28216|Betaproteobacteria,4ADNV@80864|Comamonadaceae	28216|Betaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
REGS1_k127_6156828_3	443598.AUFA01000003_gene2223	2.597e-30	129.0	COG3391@1|root,COG3391@2|Bacteria,1RFWG@1224|Proteobacteria,2U7T8@28211|Alphaproteobacteria,3K2MV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_6192915_11	1403819.BATR01000086_gene2522	2.144e-39	151.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	yhhY	-	-	ko:K03825	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1
REGS1_k127_6192915_15	326424.FRAAL6168	0.0001	51.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase,Glyoxalase_2
REGS1_k127_6192915_9	485914.Hmuk_0398	1.494e-54	203.0	COG0451@1|root,arCOG03018@2157|Archaea,2XWB1@28890|Euryarchaeota,23TGM@183963|Halobacteria	183963|Halobacteria	M	NAD-dependent epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase,NAD_binding_10
REGS1_k127_6192915_8	1128421.JAGA01000002_gene1228	1.458e-65	232.0	COG1801@1|root,COG1801@2|Bacteria,2NPRG@2323|unclassified Bacteria	2|Bacteria	S	Protein of unknown function DUF72	yecE	-	-	-	-	-	-	-	-	-	-	-	DUF72
REGS1_k127_6192915_13	324602.Caur_1733	1.587e-25	108.0	COG3695@1|root,COG3695@2|Bacteria,2G7CY@200795|Chloroflexi,37621@32061|Chloroflexia	32061|Chloroflexia	L	PFAM Methylated-DNA- protein -cysteine S-methyltransferase	-	-	-	ko:K07443	-	-	-	-	ko00000	-	-	-	DNA_binding_1
REGS1_k127_6192915_1	867845.KI911784_gene1030	2.361e-198	639.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,2G5Q5@200795|Chloroflexi,37579@32061|Chloroflexia	32061|Chloroflexia	EU	PFAM peptidase S9 prolyl oligopeptidase active site domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
REGS1_k127_6192915_6	868864.Dester_0409	2.502e-91	305.0	COG0177@1|root,COG0177@2|Bacteria,2G3TX@200783|Aquificae	200783|Aquificae	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
REGS1_k127_6192915_10	383372.Rcas_2923	2.368e-51	193.0	COG0314@1|root,COG1977@1|root,COG0314@2|Bacteria,COG1977@2|Bacteria,2G6YQ@200795|Chloroflexi,376I2@32061|Chloroflexia	32061|Chloroflexia	H	PFAM molybdopterin biosynthesis MoaE protein	moaD	-	2.8.1.12	ko:K03635,ko:K21142	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoaE,ThiS
REGS1_k127_6192915_4	485913.Krac_1174	4.844e-102	342.0	COG0861@1|root,COG0861@2|Bacteria,2G66P@200795|Chloroflexi	200795|Chloroflexi	P	PFAM Integral membrane protein TerC	-	-	-	ko:K05794	-	-	-	-	ko00000	-	-	-	TerC
REGS1_k127_6192915_0	926569.ANT_10570	1.24e-262	828.0	COG1185@1|root,COG1185@2|Bacteria,2G5TS@200795|Chloroflexi	200795|Chloroflexi	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004654,GO:0005488,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
REGS1_k127_6192915_12	246194.CHY_1760	6.516e-30	120.0	COG0184@1|root,COG0184@2|Bacteria,1VA5C@1239|Firmicutes,24MRM@186801|Clostridia,42GTG@68295|Thermoanaerobacterales	186801|Clostridia	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	-	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
REGS1_k127_6192915_14	999541.bgla_2g16270	1.385e-09	67.0	COG3258@1|root,COG3258@2|Bacteria,1QTYW@1224|Proteobacteria,2VIQV@28216|Betaproteobacteria,1K6FN@119060|Burkholderiaceae	28216|Betaproteobacteria	C	cytochrome	-	-	-	ko:K08738	ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	3.D.4.6	-	-	Cytochrome_CBB3
REGS1_k127_6192915_7	1150474.JQJI01000048_gene1240	4.753e-88	301.0	COG1173@1|root,COG1173@2|Bacteria,2GCHA@200918|Thermotogae	200918|Thermotogae	EP	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
REGS1_k127_6192915_3	484019.THA_33	5.403e-109	364.0	COG0601@1|root,COG0601@2|Bacteria,2GBX3@200918|Thermotogae	200918|Thermotogae	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
REGS1_k127_6192915_5	1150474.JQJI01000029_gene888	9.567e-102	357.0	COG0747@1|root,COG0747@2|Bacteria,2GC5G@200918|Thermotogae	200918|Thermotogae	E	PFAM extracellular solute-binding protein, family 5	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
REGS1_k127_6192915_2	1382356.JQMP01000004_gene644	3.277e-120	388.0	COG4608@1|root,COG4608@2|Bacteria,2G5R5@200795|Chloroflexi,27XY8@189775|Thermomicrobia	189775|Thermomicrobia	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
REGS1_k127_6197945_0	926550.CLDAP_01930	1.503e-92	329.0	COG4713@1|root,COG4713@2|Bacteria,2GA9E@200795|Chloroflexi	2|Bacteria	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	DUF2142
REGS1_k127_6197945_1	926569.ANT_16190	1.623e-68	239.0	COG0182@1|root,COG0182@2|Bacteria,2G5Z3@200795|Chloroflexi	200795|Chloroflexi	J	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	mtnA	-	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	-	IF-2B
REGS1_k127_6214226_1	926550.CLDAP_12040	3.021e-105	351.0	COG0536@1|root,COG0536@2|Bacteria,2G5ZT@200795|Chloroflexi	200795|Chloroflexi	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	DUF1967,GTP1_OBG,MMR_HSR1
REGS1_k127_6214226_2	926550.CLDAP_12030	8.577e-64	224.0	COG1057@1|root,COG1057@2|Bacteria,2G6MY@200795|Chloroflexi	200795|Chloroflexi	F	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	-	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
REGS1_k127_6214226_3	1499498.EV05_0808	7.615e-42	167.0	COG1402@1|root,COG1402@2|Bacteria,1G0HM@1117|Cyanobacteria,1MKZE@1212|Prochloraceae	1117|Cyanobacteria	S	Alternative locus ID	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
REGS1_k127_6214226_0	1128421.JAGA01000002_gene557	2.942e-219	685.0	COG2866@1|root,COG2866@2|Bacteria,2NPI7@2323|unclassified Bacteria	2|Bacteria	E	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
REGS1_k127_6229966_1	926569.ANT_12590	3.531e-34	138.0	COG2217@1|root,COG2217@2|Bacteria,2G5J7@200795|Chloroflexi	200795|Chloroflexi	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
REGS1_k127_6229966_2	326427.Cagg_3411	2.845e-23	102.0	COG1937@1|root,COG1937@2|Bacteria,2G7H9@200795|Chloroflexi,377N3@32061|Chloroflexia	32061|Chloroflexia	S	Metal-sensitive transcriptional repressor	-	-	-	ko:K21600	-	-	-	-	ko00000,ko03000	-	-	-	Trns_repr_metal
REGS1_k127_6229966_4	192952.MM_1054	2.88e-06	60.0	arCOG02499@1|root,arCOG02499@2157|Archaea	2157|Archaea	S	Periplasmic copper-binding protein (NosD)	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,CARDB,CarboxypepD_reg,NosD
REGS1_k127_6229966_3	1232683.ADIMK_0855	5.294e-11	68.0	2F71N@1|root,33ZH9@2|Bacteria,1NXSR@1224|Proteobacteria,1SPX7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_6229966_0	1303518.CCALI_01127	7.498e-61	213.0	COG2362@1|root,COG2362@2|Bacteria	2|Bacteria	E	D-aminopeptidase	-	-	-	ko:K16203	-	-	-	-	ko00000,ko01000,ko01002	3.A.1.5.2	-	-	Peptidase_M55
REGS1_k127_6258135_1	272134.KB731324_gene5159	9.89e-07	55.0	COG4423@1|root,COG4423@2|Bacteria	2|Bacteria	S	positive regulation of growth	-	-	-	ko:K19687	-	-	-	-	ko00000,ko02048	-	-	-	PSK_trans_fac
REGS1_k127_6258135_2	357808.RoseRS_2669	2.388e-05	57.0	COG0651@1|root,COG0651@2|Bacteria,2GAD0@200795|Chloroflexi,375GT@32061|Chloroflexia	32061|Chloroflexia	CP	PFAM NADH Ubiquinone plastoquinone (complex I)	-	-	-	-	-	-	-	-	-	-	-	-	Proton_antipo_M
REGS1_k127_6258135_3	357808.RoseRS_2670	2.833e-05	54.0	2F8YW@1|root,341AP@2|Bacteria,2GAD5@200795|Chloroflexi,375HY@32061|Chloroflexia	32061|Chloroflexia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_6258135_0	1379698.RBG1_1C00001G1193	8.836e-125	411.0	COG0006@1|root,COG0006@2|Bacteria,2NQIC@2323|unclassified Bacteria	2|Bacteria	E	Metallopeptidase family M24	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M24
REGS1_k127_6266075_0	1128421.JAGA01000002_gene1541	7.867e-139	456.0	COG1205@1|root,COG1205@2|Bacteria,2NNKJ@2323|unclassified Bacteria	2|Bacteria	L	Domain of unknown function (DUF1998)	yprA	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360	-	ko:K06877	-	-	-	-	ko00000	-	-	-	DEAD,DUF1998,Helicase_C
REGS1_k127_6284292_0	56107.Cylst_4383	1.567e-95	328.0	2BZ5C@1|root,33RFU@2|Bacteria,1GNQZ@1117|Cyanobacteria,1HRUW@1161|Nostocales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_6284292_1	479434.Sthe_1819	5.642e-38	147.0	COG0735@1|root,COG0735@2|Bacteria,2G723@200795|Chloroflexi,27Z9F@189775|Thermomicrobia	189775|Thermomicrobia	P	Ferric uptake regulator family	-	-	-	ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
REGS1_k127_6313627_0	926569.ANT_16840	1.244e-190	618.0	COG0013@1|root,COG0013@2|Bacteria,2G5KW@200795|Chloroflexi	200795|Chloroflexi	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
REGS1_k127_6313627_3	926550.CLDAP_11390	5.237e-41	169.0	COG3299@1|root,COG3299@2|Bacteria	2|Bacteria	S	Baseplate J-like protein	-	-	3.2.1.78	ko:K01218	ko00051,ko02024,map00051,map02024	-	R01332	RC00467	ko00000,ko00001,ko01000	-	GH26	-	Baseplate_J,PA14,fn3
REGS1_k127_6313627_4	688270.Celal_3762	2.736e-26	127.0	COG3291@1|root,COG3291@2|Bacteria,4PHZA@976|Bacteroidetes,1IGQC@117743|Flavobacteriia,1F9WN@104264|Cellulophaga	976|Bacteroidetes	S	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	PKD
REGS1_k127_6313627_5	1521187.JPIM01000030_gene1516	1.656e-20	96.0	COG0816@1|root,COG0816@2|Bacteria,2G74F@200795|Chloroflexi,375V0@32061|Chloroflexia	32061|Chloroflexia	J	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA	-	GO:0000966,GO:0000967,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	-	ko:K07447	-	-	-	-	ko00000,ko01000	-	-	-	RuvX
REGS1_k127_6313627_2	926550.CLDAP_39240	3.147e-66	241.0	COG1559@1|root,COG1559@2|Bacteria,2G6G8@200795|Chloroflexi	200795|Chloroflexi	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
REGS1_k127_6313627_6	670487.Ocepr_1561	2.57e-14	79.0	2DQNP@1|root,337TM@2|Bacteria,1WJYU@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_6313627_1	316274.Haur_4083	2.53e-130	427.0	COG0297@1|root,COG0297@2|Bacteria,2G7ZU@200795|Chloroflexi,375BU@32061|Chloroflexia	32061|Chloroflexia	G	PFAM glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
REGS1_k127_6313627_7	28072.Nos7524_1819	4.794e-09	64.0	COG1404@1|root,COG1572@1|root,COG2374@1|root,COG2931@1|root,COG3209@1|root,COG3291@1|root,COG4932@1|root,COG1404@2|Bacteria,COG1572@2|Bacteria,COG2374@2|Bacteria,COG2931@2|Bacteria,COG3209@2|Bacteria,COG3291@2|Bacteria,COG4932@2|Bacteria,1GIN1@1117|Cyanobacteria,1HNE9@1161|Nostocales	1117|Cyanobacteria	MOQ	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta,PPC,Peptidase_S8,SdrD_B
REGS1_k127_6315893_1	1220534.B655_1297	6.277e-46	172.0	arCOG12322@1|root,arCOG12322@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_6315893_0	765420.OSCT_1742	9.212e-245	776.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
REGS1_k127_6327163_0	1089553.Tph_c25930	3.016e-176	567.0	COG0085@1|root,COG0085@2|Bacteria,1TP96@1239|Firmicutes,247J1@186801|Clostridia,42ETP@68295|Thermoanaerobacterales	186801|Clostridia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
REGS1_k127_6329921_5	1457250.BBMO01000002_gene2316	2.857e-12	72.0	arCOG00373@1|root,arCOG00373@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_6329921_0	1306174.JODP01000002_gene5612	1.603e-146	483.0	COG0661@1|root,COG0661@2|Bacteria,2GJQ6@201174|Actinobacteria	201174|Actinobacteria	S	unusual protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	ABC1
REGS1_k127_6329921_7	981383.AEWH01000008_gene3680	3.613e-05	50.0	2E33B@1|root,32Y3G@2|Bacteria,1VIC5@1239|Firmicutes,4HQV1@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_6329921_3	477974.Daud_0731	7.649e-56	214.0	COG0823@1|root,COG0823@2|Bacteria,1V099@1239|Firmicutes,24FNQ@186801|Clostridia,260RC@186807|Peptococcaceae	186801|Clostridia	U	Periplasmic component of the Tol biopolymer transport system	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40
REGS1_k127_6329921_2	446469.Sked_02650	5.458e-62	225.0	COG0642@1|root,COG2205@2|Bacteria,2IIK0@201174|Actinobacteria	201174|Actinobacteria	T	ATPase histidine kinase DNA gyrase B HSP90 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
REGS1_k127_6329921_1	1123320.KB889562_gene6566	3.927e-86	292.0	COG0745@1|root,COG0745@2|Bacteria,2H3IN@201174|Actinobacteria	201174|Actinobacteria	T	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
REGS1_k127_6329921_4	765420.OSCT_1089	1.793e-12	75.0	COG2304@1|root,COG2304@2|Bacteria,2GB2G@200795|Chloroflexi,377SY@32061|Chloroflexia	32061|Chloroflexia	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA_2
REGS1_k127_6329921_6	1121946.AUAX01000006_gene3395	1.274e-05	51.0	COG2304@1|root,COG2304@2|Bacteria,2GKDC@201174|Actinobacteria,4D8RR@85008|Micromonosporales	201174|Actinobacteria	S	Domain of unknown function (DUF3520)	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	DUF3520,VWA,vWF_A
REGS1_k127_6330850_4	926550.CLDAP_34110	2.05e-34	150.0	COG1305@1|root,COG1305@2|Bacteria,2G66M@200795|Chloroflexi	200795|Chloroflexi	E	PFAM transglutaminase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
REGS1_k127_6330850_2	926550.CLDAP_34120	1.507e-56	214.0	COG1721@1|root,COG1721@2|Bacteria,2G5XH@200795|Chloroflexi	200795|Chloroflexi	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
REGS1_k127_6330850_1	765420.OSCT_0996	2.193e-61	221.0	COG0265@1|root,COG0265@2|Bacteria,2G6KV@200795|Chloroflexi,375DX@32061|Chloroflexia	32061|Chloroflexia	O	PFAM peptidase S1 and S6, chymotrypsin Hap	-	-	1.3.1.74	ko:K08070	-	-	-	-	ko00000,ko01000	-	-	-	PDZ_2,Trypsin_2
REGS1_k127_6330850_9	926569.ANT_25530	2.965e-07	63.0	COG4242@1|root,COG4242@2|Bacteria	2|Bacteria	PQ	Belongs to the peptidase S51 family	cphB	-	3.4.15.6	ko:K13282	-	-	R09722	RC00064,RC00141	ko00000,ko01000,ko01002	-	-	-	Peptidase_S51
REGS1_k127_6330850_3	1501230.ET33_10075	5.959e-37	155.0	COG0477@1|root,COG2814@2|Bacteria,1TS1D@1239|Firmicutes,4HCUB@91061|Bacilli,26UPF@186822|Paenibacillaceae	91061|Bacilli	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like
REGS1_k127_6330850_0	383372.Rcas_1995	3.348e-62	218.0	COG1403@1|root,COG1403@2|Bacteria,2G6WV@200795|Chloroflexi,375TQ@32061|Chloroflexia	32061|Chloroflexia	L	SMART HNH nuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH_5
REGS1_k127_6330850_8	926550.CLDAP_35190	9.232e-23	101.0	2FKJC@1|root,34C6D@2|Bacteria,2G9T3@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_6330850_6	861299.J421_0499	1.493e-24	104.0	COG1278@1|root,COG1278@2|Bacteria	2|Bacteria	K	Cold shock	cspA	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
REGS1_k127_6330850_5	335543.Sfum_0084	3.532e-25	109.0	COG0724@1|root,COG0724@2|Bacteria,1N6VR@1224|Proteobacteria,42UQP@68525|delta/epsilon subdivisions,2WQKU@28221|Deltaproteobacteria,2MS96@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	RNA recognition motif	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
REGS1_k127_6330850_7	179408.Osc7112_2111	4.051e-24	106.0	COG1187@1|root,COG1187@2|Bacteria,1G56K@1117|Cyanobacteria,1H75S@1150|Oscillatoriales	1117|Cyanobacteria	J	Belongs to the pseudouridine synthase RsuA family	-	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.20	ko:K06181	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2
REGS1_k127_6335483_1	1122223.KB890699_gene573	2.158e-34	135.0	COG1092@1|root,COG1092@2|Bacteria,1WI3V@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	J	SAM-dependent methyltransferase	-	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Met_10,Methyltrans_SAM
REGS1_k127_6335483_0	926569.ANT_09980	1.774e-162	522.0	COG0085@1|root,COG0085@2|Bacteria,2G5VH@200795|Chloroflexi	200795|Chloroflexi	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
REGS1_k127_6336985_0	926550.CLDAP_22330	1.188e-237	749.0	COG1132@1|root,COG1132@2|Bacteria,2G63W@200795|Chloroflexi	200795|Chloroflexi	V	PFAM ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
REGS1_k127_6336985_2	485913.Krac_2105	7.383e-77	264.0	COG0412@1|root,COG0412@2|Bacteria,2G868@200795|Chloroflexi	200795|Chloroflexi	Q	PFAM Dienelactone hydrolase	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
REGS1_k127_6336985_3	1382306.JNIM01000001_gene284	2.9e-64	230.0	COG2120@1|root,COG2120@2|Bacteria,2G6W3@200795|Chloroflexi	200795|Chloroflexi	S	PFAM LmbE family protein	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
REGS1_k127_6336985_4	267608.RSc0932	7.553e-49	190.0	COG2133@1|root,COG2133@2|Bacteria,1MVK5@1224|Proteobacteria,2VIRC@28216|Betaproteobacteria,1K4ET@119060|Burkholderiaceae	28216|Betaproteobacteria	G	sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	GSDH,SGL
REGS1_k127_6336985_5	1237149.C900_00574	7.697e-35	146.0	COG2267@1|root,COG2267@2|Bacteria,4NF80@976|Bacteroidetes	976|Bacteroidetes	I	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
REGS1_k127_6336985_1	485913.Krac_1302	6.227e-94	317.0	COG0265@1|root,COG0265@2|Bacteria,2G8HP@200795|Chloroflexi	200795|Chloroflexi	O	Trypsin	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
REGS1_k127_6374887_2	1220534.B655_1297	4.95e-67	235.0	arCOG12322@1|root,arCOG12322@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_6374887_1	765420.OSCT_1741	4.965e-99	330.0	COG1136@1|root,COG1136@2|Bacteria,2G69N@200795|Chloroflexi	200795|Chloroflexi	P	Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
REGS1_k127_6374887_0	195250.CM001776_gene3300	8.206e-205	655.0	COG0474@1|root,COG0474@2|Bacteria,1G0JX@1117|Cyanobacteria,1GYRH@1129|Synechococcus	1117|Cyanobacteria	P	COG0474 Cation transport ATPase	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
REGS1_k127_6384236_2	383372.Rcas_2604	1.829e-36	154.0	COG2373@1|root,COG2373@2|Bacteria,2G5XN@200795|Chloroflexi,37651@32061|Chloroflexia	32061|Chloroflexia	S	Alpha-2-macroglobulin family	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,Big_5
REGS1_k127_6384236_1	485913.Krac_4076	8.413e-47	175.0	2CK59@1|root,32RQ2@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
REGS1_k127_6384236_0	765420.OSCT_2889	1.085e-95	328.0	COG0744@1|root,COG0744@2|Bacteria,2G5ZG@200795|Chloroflexi,376FV@32061|Chloroflexia	32061|Chloroflexia	M	Penicillin-Binding Protein C-terminus Family	-	-	-	-	-	-	-	-	-	-	-	-	BiPBP_C,Transgly,Transpeptidase
REGS1_k127_6389273_9	1303518.CCALI_01986	8.365e-77	273.0	COG3605@1|root,COG3920@1|root,COG3605@2|Bacteria,COG3920@2|Bacteria	2|Bacteria	T	Histidine kinase	pdtaS	-	2.1.1.80,2.7.13.3,3.1.1.61,3.1.4.52,3.6.3.17,4.2.1.75,4.6.1.1	ko:K00936,ko:K01719,ko:K01768,ko:K02030,ko:K02584,ko:K10441,ko:K13924,ko:K20962	ko00230,ko00860,ko01100,ko01110,ko01120,ko02010,ko02020,ko02025,ko02030,ko04113,ko04213,ko05111,map00230,map00860,map01100,map01110,map01120,map02010,map02020,map02025,map02030,map04113,map04213,map05111	M00121,M00212,M00236,M00506,M00695,M00839	R00089,R00434,R03165	RC00295,RC01861	ko00000,ko00001,ko00002,ko01000,ko01001,ko02000,ko02022,ko02035,ko03000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19,3.A.1.3	-	-	GAF,GAF_2,HATPase_c,HATPase_c_2,H_kinase_N,HisKA_2,PAS,PAS_3,PAS_4,PAS_9,Response_reg,TPR_12,TPR_8
REGS1_k127_6389273_3	429009.Adeg_1891	8.952e-216	681.0	COG0174@1|root,COG0174@2|Bacteria,1TNZA@1239|Firmicutes,2489S@186801|Clostridia,42FXP@68295|Thermoanaerobacterales	186801|Clostridia	E	Glutamine synthetase, catalytic domain	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
REGS1_k127_6389273_6	1380390.JIAT01000010_gene4303	1.002e-155	500.0	COG0247@1|root,COG0247@2|Bacteria,2H9RN@201174|Actinobacteria	201174|Actinobacteria	C	Glycerol-3-phosphate dehydrogenase	glpC	-	1.1.5.3	ko:K00113,ko:K18930	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	CCG,Fer4_8
REGS1_k127_6389273_8	1380390.JIAT01000010_gene4302	1.775e-105	356.0	COG3075@1|root,COG3075@2|Bacteria,2GMNS@201174|Actinobacteria	201174|Actinobacteria	E	Glycerol-3-phosphate dehydrogenase	glpB	-	1.1.5.3	ko:K00112	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	FAD_binding_2
REGS1_k127_6389273_4	1380390.JIAT01000010_gene4301	4.657e-189	603.0	COG0578@1|root,COG0578@2|Bacteria,2GJKN@201174|Actinobacteria	201174|Actinobacteria	C	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family	glpA	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,Fer2_BFD
REGS1_k127_6389273_0	357808.RoseRS_1768	2.944e-252	784.0	COG0554@1|root,COG0554@2|Bacteria,2G5TV@200795|Chloroflexi,3751K@32061|Chloroflexia	32061|Chloroflexia	F	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK	GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
REGS1_k127_6389273_10	457429.ABJI02000207_gene2774	2.214e-48	180.0	2AQME@1|root,31FUG@2|Bacteria,2GJ2E@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_6389273_1	469371.Tbis_2599	3.17e-233	730.0	COG1032@1|root,COG1032@2|Bacteria,2HW71@201174|Actinobacteria,4E7P4@85010|Pseudonocardiales	201174|Actinobacteria	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
REGS1_k127_6389273_13	1259795.ARJK01000003_gene1268	2.389e-33	138.0	COG1225@1|root,COG1225@2|Bacteria	2|Bacteria	O	peroxiredoxin activity	-	-	1.11.1.15,2.7.13.3	ko:K03564,ko:K07638	ko02020,ko02026,map02020,map02026	M00445,M00742,M00743	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	AhpC-TSA
REGS1_k127_6389273_7	765420.OSCT_0642	3.804e-112	367.0	COG2197@1|root,COG2197@2|Bacteria,2G7U4@200795|Chloroflexi,376QK@32061|Chloroflexia	32061|Chloroflexia	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
REGS1_k127_6389273_5	765420.OSCT_0643	1.44e-158	524.0	COG4585@1|root,COG4585@2|Bacteria,2G7W5@200795|Chloroflexi,3767N@32061|Chloroflexia	32061|Chloroflexia	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_6389273_2	706587.Desti_2787	1.917e-219	695.0	COG1164@1|root,COG1164@2|Bacteria	2|Bacteria	E	metalloendopeptidase activity	pepF	-	-	ko:K08602	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3
REGS1_k127_6389273_11	1128421.JAGA01000001_gene2006	2.591e-39	149.0	COG2363@1|root,COG2363@2|Bacteria,2NRMS@2323|unclassified Bacteria	2|Bacteria	S	Protein of unknown function (DUF423)	ywdK	-	-	-	-	-	-	-	-	-	-	-	DUF423
REGS1_k127_6389273_12	332101.JIBU02000025_gene3245	1.449e-34	133.0	COG2872@1|root,COG2872@2|Bacteria,1UHS6@1239|Firmicutes,24AK0@186801|Clostridia,36GRN@31979|Clostridiaceae	186801|Clostridia	S	Threonyl alanyl tRNA synthetase SAD	-	-	-	ko:K07050	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA-synt_2c,tRNA_SAD
REGS1_k127_6391705_0	926550.CLDAP_29930	1.775e-104	349.0	COG0438@1|root,COG0438@2|Bacteria,2G82Z@200795|Chloroflexi	200795|Chloroflexi	M	PFAM glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
REGS1_k127_6391705_1	926550.CLDAP_29920	1.694e-101	343.0	COG0438@1|root,COG0438@2|Bacteria,2G6I1@200795|Chloroflexi	200795|Chloroflexi	M	PFAM glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4
REGS1_k127_6391705_2	383372.Rcas_2690	1.413e-52	198.0	COG0741@1|root,COG1729@1|root,COG0741@2|Bacteria,COG1729@2|Bacteria,2G6NM@200795|Chloroflexi,374VP@32061|Chloroflexia	32061|Chloroflexia	M	Lytic transglycosylase catalytic	-	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	SLT,TPR_16
REGS1_k127_6393449_0	926550.CLDAP_36890	4.002e-218	683.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1146@2|Bacteria,2G5M1@200795|Chloroflexi	200795|Chloroflexi	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	porA	-	1.2.7.1	ko:K00169,ko:K03737	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034,R10866	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4_16,Fer4_6,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C
REGS1_k127_6393449_1	1382306.JNIM01000001_gene3932	9.742e-49	181.0	COG0664@1|root,COG0664@2|Bacteria,2G6XU@200795|Chloroflexi	200795|Chloroflexi	K	PFAM Cyclic nucleotide-binding	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
REGS1_k127_6401792_12	926550.CLDAP_15770	1.3e-26	123.0	2EPQX@1|root,33HBF@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_6401792_15	589924.Ferp_1517	9.176e-16	82.0	COG1254@1|root,arCOG01674@2157|Archaea,2XYT5@28890|Euryarchaeota,246H6@183980|Archaeoglobi	183980|Archaeoglobi	C	Acylphosphatase	-	-	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	-	R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000	-	-	-	Acylphosphatase
REGS1_k127_6401792_9	926550.CLDAP_07780	2.004e-41	160.0	COG1418@1|root,COG1418@2|Bacteria,2G77Y@200795|Chloroflexi	200795|Chloroflexi	S	PFAM metal-dependent phosphohydrolase, HD sub domain	-	-	-	ko:K06950	-	-	-	-	ko00000	-	-	-	HD
REGS1_k127_6401792_13	1254432.SCE1572_13105	1.738e-24	118.0	COG2308@1|root,COG2308@2|Bacteria,1P9A0@1224|Proteobacteria,42PIM@68525|delta/epsilon subdivisions,2WKI0@28221|Deltaproteobacteria,2Z1SA@29|Myxococcales	28221|Deltaproteobacteria	S	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_6401792_17	1408473.JHXO01000014_gene4034	3.103e-13	76.0	COG0697@1|root,COG0697@2|Bacteria,4NHBC@976|Bacteroidetes,2FS9M@200643|Bacteroidia	976|Bacteroidetes	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
REGS1_k127_6401792_0	247490.KSU1_D1051	5.986e-228	716.0	COG2317@1|root,COG2317@2|Bacteria,2IXSU@203682|Planctomycetes	203682|Planctomycetes	E	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues	-	-	3.4.17.19	ko:K01299	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M32
REGS1_k127_6401792_2	1128421.JAGA01000002_gene1110	6.256e-86	293.0	COG0313@1|root,COG0313@2|Bacteria,2NP98@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0070677,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
REGS1_k127_6401792_4	555079.Toce_1054	1.038e-65	235.0	COG1307@1|root,COG1307@2|Bacteria,1TRM7@1239|Firmicutes,247ST@186801|Clostridia,42GID@68295|Thermoanaerobacterales	186801|Clostridia	S	TIGRFAM degV family protein	-	-	-	-	-	-	-	-	-	-	-	-	DegV
REGS1_k127_6401792_7	926569.ANT_20740	3.94e-54	198.0	COG1595@1|root,COG1595@2|Bacteria,2G6X7@200795|Chloroflexi	200795|Chloroflexi	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
REGS1_k127_6401792_6	580332.Slit_0252	5.678e-64	244.0	COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,2VJ72@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Adenylyl cyclase class-3 4 guanylyl cyclase	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc
REGS1_k127_6401792_11	926569.ANT_09970	2.079e-32	133.0	COG0394@1|root,COG0394@2|Bacteria,2G7C2@200795|Chloroflexi	200795|Chloroflexi	T	PFAM low molecular weight phosphotyrosine protein phosphatase	-	-	3.1.3.48	ko:K01104	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
REGS1_k127_6401792_10	926550.CLDAP_36380	2.713e-36	144.0	COG1544@1|root,COG1544@2|Bacteria,2G6Z4@200795|Chloroflexi	200795|Chloroflexi	J	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase	hpf	-	-	ko:K05808	-	-	-	-	ko00000,ko03009	-	-	-	Ribosom_S30AE_C,Ribosomal_S30AE
REGS1_k127_6401792_8	926569.ANT_20680	2.972e-42	165.0	COG1040@1|root,COG1040@2|Bacteria,2G6WB@200795|Chloroflexi	200795|Chloroflexi	S	competence protein	-	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
REGS1_k127_6401792_14	215803.DB30_0374	5.111e-24	106.0	COG1430@1|root,COG1430@2|Bacteria,1N7U4@1224|Proteobacteria,42VKG@68525|delta/epsilon subdivisions,2WSD0@28221|Deltaproteobacteria,2Z0K8@29|Myxococcales	28221|Deltaproteobacteria	S	Uncharacterized ACR, COG1430	-	-	-	ko:K09005	-	-	-	-	ko00000	-	-	-	DUF192
REGS1_k127_6401792_3	479434.Sthe_0521	5.799e-79	274.0	COG2064@1|root,COG2064@2|Bacteria,2G6CF@200795|Chloroflexi,27XSY@189775|Thermomicrobia	189775|Thermomicrobia	NU	Type II secretion system (T2SS), protein F	-	-	-	ko:K12511	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
REGS1_k127_6401792_5	1382356.JQMP01000003_gene2237	3.057e-64	231.0	COG4965@1|root,COG4965@2|Bacteria,2G6GS@200795|Chloroflexi,27XX2@189775|Thermomicrobia	189775|Thermomicrobia	U	Type II secretion system (T2SS), protein F	-	-	-	ko:K12510	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
REGS1_k127_6401792_1	1382356.JQMP01000003_gene2236	7.506e-183	582.0	COG4962@1|root,COG4962@2|Bacteria,2G68E@200795|Chloroflexi,27XTR@189775|Thermomicrobia	189775|Thermomicrobia	U	Type II/IV secretion system protein	-	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
REGS1_k127_6401792_16	401526.TcarDRAFT_1910	1.07e-14	79.0	COG4753@1|root,COG4963@1|root,COG4753@2|Bacteria,COG4963@2|Bacteria,1UF2S@1239|Firmicutes,4H306@909932|Negativicutes	909932|Negativicutes	KTU	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_31,Response_reg
REGS1_k127_6411600_2	867903.ThesuDRAFT_01477	5.115e-149	477.0	COG2225@1|root,COG2225@2|Bacteria,1TPE8@1239|Firmicutes,24Z0I@186801|Clostridia	186801|Clostridia	H	Belongs to the malate synthase family	-	-	2.3.3.9	ko:K01638	ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200	M00012	R00472	RC00004,RC00308,RC02747	ko00000,ko00001,ko00002,ko01000	-	-	-	Malate_synthase
REGS1_k127_6411600_0	926550.CLDAP_15220	8.391e-201	632.0	COG2224@1|root,COG2224@2|Bacteria,2G61J@200795|Chloroflexi	200795|Chloroflexi	C	PFAM isocitrate lyase and phosphorylmutase	-	-	4.1.3.1	ko:K01637	ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200	M00012	R00479	RC00311,RC00313	ko00000,ko00001,ko00002,ko01000	-	-	-	ICL
REGS1_k127_6411600_1	1128421.JAGA01000001_gene2203	1.585e-190	610.0	COG4579@1|root,COG4579@2|Bacteria	2|Bacteria	F	[isocitrate dehydrogenase (NADP+)] phosphatase activity	aceK	GO:0000166,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0004721,GO:0004722,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006081,GO:0006082,GO:0006091,GO:0006097,GO:0006099,GO:0006101,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008772,GO:0009060,GO:0009987,GO:0015980,GO:0016208,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016787,GO:0016788,GO:0016791,GO:0016999,GO:0017076,GO:0017144,GO:0018105,GO:0018193,GO:0018209,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0035639,GO:0036094,GO:0036211,GO:0042578,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044260,GO:0044262,GO:0044267,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046487,GO:0050790,GO:0055114,GO:0065007,GO:0065009,GO:0070262,GO:0071704,GO:0072350,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564	2.7.11.5	ko:K00906	-	-	-	-	ko00000,ko01000	-	-	-	AceK
REGS1_k127_6416899_0	926569.ANT_01580	2.005e-97	328.0	COG0474@1|root,COG0474@2|Bacteria,2G5ZS@200795|Chloroflexi	200795|Chloroflexi	P	TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
REGS1_k127_6416899_3	309800.C498_14111	9.679e-32	133.0	COG1238@1|root,arCOG03118@2157|Archaea,2XU8S@28890|Euryarchaeota,23TQV@183963|Halobacteria	183963|Halobacteria	S	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
REGS1_k127_6416899_4	552811.Dehly_0564	4.65e-23	106.0	COG0589@1|root,COG0589@2|Bacteria,2G91P@200795|Chloroflexi,34DF4@301297|Dehalococcoidia	301297|Dehalococcoidia	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
REGS1_k127_6416899_2	665571.STHERM_c10160	2.157e-56	223.0	COG2182@1|root,COG2182@2|Bacteria,2J5S3@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Bacterial extracellular solute-binding protein	-	-	-	ko:K15770	ko02010,map02010	M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.16,3.A.1.1.2	-	-	SBP_bac_8
REGS1_k127_6416899_5	1968.JOEV01000005_gene6325	4.607e-07	63.0	COG4213@1|root,COG4213@2|Bacteria,2GKRE@201174|Actinobacteria	201174|Actinobacteria	G	ABC transporter substrate-binding protein	-	-	-	ko:K10543	ko02010,map02010	M00215	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.4	-	-	Peripla_BP_4
REGS1_k127_6416899_1	292459.STH1114	1.575e-61	222.0	COG1015@1|root,COG1015@2|Bacteria,1UJAM@1239|Firmicutes,25EZP@186801|Clostridia	186801|Clostridia	C	Metalloenzyme superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Metalloenzyme
REGS1_k127_6420420_1	926569.ANT_26550	1.573e-46	177.0	COG3212@1|root,COG3212@2|Bacteria	2|Bacteria	T	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	PepSY
REGS1_k127_6420420_4	255470.cbdbA907	9.076e-13	70.0	COG3462@1|root,COG3462@2|Bacteria,2G9MX@200795|Chloroflexi,34DHS@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Short C-terminal domain	-	-	-	ko:K08982	-	-	-	-	ko00000	-	-	-	SHOCT
REGS1_k127_6420420_2	926550.CLDAP_28250	3.745e-43	160.0	COG3439@1|root,COG3439@2|Bacteria,2G72I@200795|Chloroflexi	200795|Chloroflexi	S	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	DUF302
REGS1_k127_6420420_0	138119.DSY0852	2.581e-55	201.0	COG0500@1|root,COG2226@2|Bacteria,1V0C5@1239|Firmicutes,24IDC@186801|Clostridia,261M8@186807|Peptococcaceae	186801|Clostridia	Q	PFAM methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
REGS1_k127_6420420_5	1128421.JAGA01000002_gene1308	0.0003341	44.0	COG2197@1|root,COG2197@2|Bacteria,2NPMZ@2323|unclassified Bacteria	2|Bacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
REGS1_k127_6420420_3	580332.Slit_1529	3.889e-19	88.0	COG0331@1|root,COG0331@2|Bacteria,1MV6N@1224|Proteobacteria,2VJF7@28216|Betaproteobacteria,44V99@713636|Nitrosomonadales	28216|Betaproteobacteria	I	TIGRFAM malonyl CoA-acyl carrier protein transacylase	fabD	-	2.3.1.39	ko:K00645,ko:K13935,ko:K15355	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
REGS1_k127_6448271_2	926569.ANT_10080	2.169e-42	156.0	COG0185@1|root,COG0185@2|Bacteria,2G6US@200795|Chloroflexi	200795|Chloroflexi	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rpsS	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
REGS1_k127_6448271_0	1321814.HMPREF9089_01120	1.758e-118	389.0	COG0090@1|root,COG0090@2|Bacteria,1TP9X@1239|Firmicutes,247XY@186801|Clostridia,25UQE@186806|Eubacteriaceae	186801|Clostridia	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	-	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
REGS1_k127_6448271_3	42256.RradSPS_1941	6.585e-15	78.0	COG0089@1|root,COG0089@2|Bacteria,2IQ7V@201174|Actinobacteria,4CQIU@84995|Rubrobacteria	84995|Rubrobacteria	J	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome	rplW	-	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
REGS1_k127_6448271_1	340099.Teth39_0375	2.853e-63	224.0	COG0088@1|root,COG0088@2|Bacteria,1TPGW@1239|Firmicutes,248SY@186801|Clostridia,42ERX@68295|Thermoanaerobacterales	186801|Clostridia	J	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome	rplD	-	-	ko:K02926	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
REGS1_k127_6455157_7	861299.J421_0673	1.536e-55	201.0	2DWKV@1|root,340YA@2|Bacteria,1ZTYS@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_6455157_1	525904.Tter_0632	1.631e-139	462.0	COG0699@1|root,COG0699@2|Bacteria,2NQN2@2323|unclassified Bacteria	2|Bacteria	S	Dynamin family	-	-	-	-	-	-	-	-	-	-	-	-	Dynamin_N
REGS1_k127_6455157_8	207559.Dde_2523	8.255e-30	130.0	COG0637@1|root,COG0637@2|Bacteria,1PUMZ@1224|Proteobacteria,42W4B@68525|delta/epsilon subdivisions,2WP0P@28221|Deltaproteobacteria,2ME45@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3	-	-	5.4.2.6	ko:K01838	ko00500,map00500	-	R02728,R11310	RC00408	ko00000,ko00001,ko01000	-	-	-	HAD_2
REGS1_k127_6455157_2	1128421.JAGA01000002_gene1647	7.756e-108	373.0	COG4412@1|root,COG4412@2|Bacteria,2NQMP@2323|unclassified Bacteria	2|Bacteria	E	Immune inhibitor A peptidase M6	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M6
REGS1_k127_6455157_9	743525.TSC_c18490	1.021e-27	128.0	COG3385@1|root,COG3385@2|Bacteria,1WI7I@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
REGS1_k127_6455157_3	138119.DSY3730	3.563e-98	353.0	COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,1UIEA@1239|Firmicutes,25EJM@186801|Clostridia,260AR@186807|Peptococcaceae	186801|Clostridia	GT	Pyruvate phosphate dikinase, PEP	ppdK	-	2.7.9.1,2.7.9.2	ko:K01006,ko:K01007	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173,M00374	R00199,R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
REGS1_k127_6455157_5	251221.35211347	5.334e-85	298.0	COG1253@1|root,COG1253@2|Bacteria,1G1AQ@1117|Cyanobacteria	1117|Cyanobacteria	S	PFAM CBS domain	-	-	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
REGS1_k127_6455157_6	926550.CLDAP_02720	1.325e-72	268.0	COG1577@1|root,COG1577@2|Bacteria,2G6DY@200795|Chloroflexi	200795|Chloroflexi	I	TIGRFAM mevalonate kinase	mvk	-	2.7.1.36	ko:K00869	ko00900,ko01100,ko01110,ko01130,ko04146,map00900,map01100,map01110,map01130,map04146	M00095	R02245	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
REGS1_k127_6455157_0	1121468.AUBR01000047_gene1876	1.076e-163	526.0	COG1541@1|root,COG1541@2|Bacteria,1TQA1@1239|Firmicutes,248G9@186801|Clostridia,42FTU@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	paaK	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
REGS1_k127_6455157_4	526225.Gobs_2142	4.597e-93	318.0	COG3391@1|root,COG4995@1|root,COG3391@2|Bacteria,COG4995@2|Bacteria,2HF98@201174|Actinobacteria,4EWDJ@85013|Frankiales	201174|Actinobacteria	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_6460111_1	1120973.AQXL01000117_gene342	6.248e-108	361.0	COG0384@1|root,COG0384@2|Bacteria,1V38B@1239|Firmicutes,4IRC7@91061|Bacilli	91061|Bacilli	S	phenazine biosynthesis	-	-	5.3.3.17	ko:K06998	ko00405,ko01130,ko02024,map00405,map01130,map02024	M00835	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	PhzC-PhzF
REGS1_k127_6460111_0	1121468.AUBR01000036_gene1308	8.849e-148	500.0	COG2203@1|root,COG3437@1|root,COG3605@1|root,COG4936@1|root,COG2203@2|Bacteria,COG3437@2|Bacteria,COG3605@2|Bacteria,COG4936@2|Bacteria,1V7YT@1239|Firmicutes,25ET2@186801|Clostridia,42JGC@68295|Thermoanaerobacterales	186801|Clostridia	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HD,PocR,SBP_bac_3
REGS1_k127_6460111_3	794846.AJQU01000110_gene4136	9.018e-29	121.0	COG2020@1|root,COG2020@2|Bacteria,1MZ7S@1224|Proteobacteria,2UBYC@28211|Alphaproteobacteria,4BC19@82115|Rhizobiaceae	28211|Alphaproteobacteria	O	Phospholipid methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
REGS1_k127_6460111_2	1123230.ARQJ01000029_gene169	1.424e-42	162.0	COG0498@1|root,COG0498@2|Bacteria,1TP25@1239|Firmicutes,4HA1F@91061|Bacilli,4GXEP@90964|Staphylococcaceae	91061|Bacilli	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	-	-	-	-	-	-	-	-	-	-	-	-	PALP
REGS1_k127_646023_5	1353537.TP2_13790	0.0001028	45.0	COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,2TRVF@28211|Alphaproteobacteria,2XPE5@285107|Thioclava	28211|Alphaproteobacteria	H	AMP-binding enzyme C-terminal domain	-	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
REGS1_k127_646023_1	864565.HMPREF0379_0940	9.796e-58	211.0	COG1024@1|root,COG1024@2|Bacteria,1TQ89@1239|Firmicutes,247RK@186801|Clostridia	186801|Clostridia	I	Belongs to the enoyl-CoA hydratase isomerase family	crt	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	-	ECH_1
REGS1_k127_646023_4	42256.RradSPS_0047	7.119e-14	83.0	2DFV5@1|root,2ZT9W@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_646023_3	485913.Krac_11177	3.201e-28	121.0	COG1051@1|root,COG1051@2|Bacteria	2|Bacteria	F	GDP-mannose mannosyl hydrolase activity	mutT2	-	3.6.1.55	ko:K03574,ko:K13669	-	-	-	-	ko00000,ko01000,ko01003,ko03400	-	GT87	-	NUDIX
REGS1_k127_646023_0	926569.ANT_30490	6.644e-62	224.0	COG0496@1|root,COG0496@2|Bacteria	2|Bacteria	P	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates	surE	-	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	SurE
REGS1_k127_646023_2	1283299.AUKG01000001_gene1357	2.406e-43	171.0	COG0451@1|root,COG0451@2|Bacteria,2GMHH@201174|Actinobacteria	201174|Actinobacteria	M	3-beta hydroxysteroid dehydrogenase isomerase	-	-	-	ko:K21793	ko00333,ko01130,map00333,map01130	M00838	R11663,R11666	-	ko00000,ko00001,ko00002	-	-	-	Epimerase
REGS1_k127_649952_2	1288826.MSNKSG1_09953	7.482e-16	83.0	COG3387@1|root,COG3387@2|Bacteria,1MW9J@1224|Proteobacteria,1T2G2@1236|Gammaproteobacteria,465X7@72275|Alteromonadaceae	1236|Gammaproteobacteria	G	PFAM Glycoside hydrolase 15-related	-	-	-	-	-	-	-	-	-	-	-	-	F5_F8_type_C,GDE_C
REGS1_k127_649952_1	877455.Metbo_0127	1.249e-40	160.0	COG0638@1|root,arCOG00970@2157|Archaea,2Y1U9@28890|Euryarchaeota,23PBD@183925|Methanobacteria	183925|Methanobacteria	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_649952_0	926550.CLDAP_23390	4.164e-56	216.0	COG1807@1|root,COG1807@2|Bacteria,2G9BJ@200795|Chloroflexi	2|Bacteria	M	Protein of unknown function (DUF2723)	-	-	-	ko:K14340	-	-	-	-	ko00000,ko01000,ko01003	-	-	-	PMT_2
REGS1_k127_650593_0	926550.CLDAP_08170	4.357e-141	456.0	COG1077@1|root,COG1077@2|Bacteria,2G62K@200795|Chloroflexi	200795|Chloroflexi	D	TIGRFAM cell shape determining protein, MreB Mrl family	-	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
REGS1_k127_650593_1	479434.Sthe_0091	3.533e-49	181.0	COG1607@1|root,COG1607@2|Bacteria,2G7A6@200795|Chloroflexi	200795|Chloroflexi	I	PFAM thioesterase superfamily protein	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
REGS1_k127_650593_2	383372.Rcas_2401	2.607e-32	135.0	COG3210@1|root,COG3210@2|Bacteria,2G8VW@200795|Chloroflexi,377DU@32061|Chloroflexia	2|Bacteria	M	TIGRFAM polymorphic outer membrane protein	-	-	-	ko:K21449	-	-	-	-	ko00000,ko02000	1.B.40.2	-	-	Beta_helix,Peptidase_S74
REGS1_k127_6518410_5	1347086.CCBA010000026_gene3184	6.428e-55	200.0	COG1131@1|root,COG1131@2|Bacteria,1V7J1@1239|Firmicutes,4HJPG@91061|Bacilli,1ZPZ7@1386|Bacillus	91061|Bacilli	V	COG1131 ABC-type multidrug transport system, ATPase component	-	-	3.6.3.41	ko:K02193	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.107	-	-	ABC_tran
REGS1_k127_6518410_4	926569.ANT_19400	3.439e-63	224.0	COG2386@1|root,COG2386@2|Bacteria,2G6TN@200795|Chloroflexi	200795|Chloroflexi	O	PFAM cytochrome c-type biogenesis protein CcmB	ccmB	-	-	ko:K02194	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	CcmB
REGS1_k127_6518410_6	639282.DEFDS_0177	1.168e-54	200.0	COG0755@1|root,COG0755@2|Bacteria,2GF7F@200930|Deferribacteres	200930|Deferribacteres	O	Cytochrome C assembly protein	-	-	-	ko:K02195	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	Cytochrom_C_asm
REGS1_k127_6518410_10	765420.OSCT_1795	4.528e-32	132.0	COG0526@1|root,COG0526@2|Bacteria,2G72F@200795|Chloroflexi,377HE@32061|Chloroflexia	32061|Chloroflexia	CO	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
REGS1_k127_6518410_9	1321778.HMPREF1982_04568	6.057e-49	184.0	COG0785@1|root,COG0785@2|Bacteria,1TQH1@1239|Firmicutes,249IS@186801|Clostridia,2682M@186813|unclassified Clostridiales	186801|Clostridia	O	Cytochrome C biogenesis protein transmembrane region	ccdA	-	-	ko:K06196	-	-	-	-	ko00000,ko02000	5.A.1.2	-	-	AhpC-TSA,DsbD,Redoxin
REGS1_k127_6518410_8	324602.Caur_1114	1.001e-51	194.0	COG1091@1|root,COG1091@2|Bacteria,2G9A2@200795|Chloroflexi,375MR@32061|Chloroflexia	32061|Chloroflexia	M	PFAM NAD-dependent epimerase dehydratase	-	-	1.1.1.133	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000	-	-	-	RmlD_sub_bind
REGS1_k127_6518410_7	574087.Acear_1020	1.275e-54	201.0	COG0571@1|root,COG0571@2|Bacteria,1TPGC@1239|Firmicutes,249QD@186801|Clostridia,3WAJK@53433|Halanaerobiales	186801|Clostridia	J	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	rnc	-	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
REGS1_k127_6518410_1	1382306.JNIM01000001_gene105	2.828e-145	473.0	COG0304@1|root,COG0304@2|Bacteria,2G5K7@200795|Chloroflexi	200795|Chloroflexi	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
REGS1_k127_6518410_2	1382306.JNIM01000001_gene1297	4.483e-107	356.0	COG0709@1|root,COG0709@2|Bacteria,2G5W4@200795|Chloroflexi	200795|Chloroflexi	H	Synthesizes selenophosphate from selenide and ATP	selD	-	2.7.9.3	ko:K01008	ko00450,ko01100,map00450,map01100	-	R03595	RC00002,RC02878	ko00000,ko00001,ko01000,ko03016	-	-	-	AIRS,AIRS_C
REGS1_k127_6518410_0	926569.ANT_27070	1.277e-255	813.0	COG0577@1|root,COG4591@1|root,COG0577@2|Bacteria,COG4591@2|Bacteria,2G6IW@200795|Chloroflexi	200795|Chloroflexi	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
REGS1_k127_6518410_3	926569.ANT_27060	8.376e-74	252.0	COG1136@1|root,COG1136@2|Bacteria,2G69N@200795|Chloroflexi	200795|Chloroflexi	P	Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
REGS1_k127_6527605_1	357808.RoseRS_1536	9.549e-31	134.0	COG1196@1|root,COG1196@2|Bacteria,2G788@200795|Chloroflexi,376Y7@32061|Chloroflexia	32061|Chloroflexia	D	Domain of unknown function (DUF4349)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4349
REGS1_k127_6527605_0	926569.ANT_25520	8.542e-52	190.0	COG0503@1|root,COG0503@2|Bacteria,2G71F@200795|Chloroflexi	200795|Chloroflexi	F	Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis	xpt	-	2.4.2.22	ko:K03816	ko00230,ko01100,ko01110,map00230,map01100,map01110	-	R01229,R02142	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
REGS1_k127_6527605_2	525904.Tter_1043	3.612e-08	66.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	peaD	-	-	-	-	-	-	-	-	-	-	-	Lactonase,Rhomboid
REGS1_k127_6542197_2	357808.RoseRS_1121	4.163e-112	370.0	COG2141@1|root,COG2141@2|Bacteria,2G5MF@200795|Chloroflexi,376CU@32061|Chloroflexia	32061|Chloroflexia	C	PFAM luciferase family protein	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
REGS1_k127_6542197_4	479434.Sthe_0942	8.242e-71	246.0	COG1573@1|root,COG1573@2|Bacteria,2G6BR@200795|Chloroflexi,27XM8@189775|Thermomicrobia	189775|Thermomicrobia	L	Uracil DNA glycosylase superfamily	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
REGS1_k127_6542197_1	635013.TherJR_1402	2.215e-187	611.0	COG0595@1|root,COG0595@2|Bacteria,1TQ9G@1239|Firmicutes,2488J@186801|Clostridia,2601W@186807|Peptococcaceae	186801|Clostridia	J	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay	rnj	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,RMMBL
REGS1_k127_6542197_3	498761.HM1_1842	2.679e-75	273.0	COG0053@1|root,COG0053@2|Bacteria,1TSGY@1239|Firmicutes,2491V@186801|Clostridia	186801|Clostridia	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
REGS1_k127_6542197_5	1128421.JAGA01000003_gene3735	5.035e-49	182.0	COG1595@1|root,COG1595@2|Bacteria,2NR8H@2323|unclassified Bacteria	2|Bacteria	K	ECF sigma factor	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
REGS1_k127_6542197_6	1150399.AQYK01000002_gene2850	5.565e-08	62.0	COG5343@1|root,COG5343@2|Bacteria,2HSNE@201174|Actinobacteria,4FPJ7@85023|Microbacteriaceae	201174|Actinobacteria	S	Anti-sigma-K factor rskA	-	-	-	-	-	-	-	-	-	-	-	-	RskA
REGS1_k127_6542197_0	671143.DAMO_2972	7.707e-202	636.0	COG1217@1|root,COG1217@2|Bacteria,2NNY7@2323|unclassified Bacteria	2|Bacteria	T	Elongation factor G C-terminus	typA	GO:0000027,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006996,GO:0008150,GO:0009266,GO:0009408,GO:0009409,GO:0009628,GO:0009987,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071826,GO:0071840	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2
REGS1_k127_6575449_9	1538295.JY96_03070	6.589e-06	59.0	COG1566@1|root,COG1566@2|Bacteria,1QUDS@1224|Proteobacteria,2WHE9@28216|Betaproteobacteria	28216|Betaproteobacteria	V	HlyD family	-	-	-	ko:K01993	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3
REGS1_k127_6575449_8	595460.RRSWK_00637	1.304e-23	117.0	COG1566@1|root,COG1566@2|Bacteria,2J4Y8@203682|Planctomycetes	203682|Planctomycetes	V	Barrel-sandwich domain of CusB or HlyD membrane-fusion	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
REGS1_k127_6575449_6	1128421.JAGA01000001_gene2038	9.479e-68	247.0	COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,2NQ3V@2323|unclassified Bacteria	2|Bacteria	KT	COGs COG2208 Serine phosphatase RsbU regulator of sigma subunit	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	GAF,GAF_2,GGDEF,SpoIIE
REGS1_k127_6575449_1	926550.CLDAP_07480	2.782e-144	469.0	COG0568@1|root,COG0568@2|Bacteria,2G5W3@200795|Chloroflexi	200795|Chloroflexi	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
REGS1_k127_6575449_5	1123386.AUIW01000006_gene1645	3.092e-79	302.0	COG2202@1|root,COG3437@1|root,COG2202@2|Bacteria,COG3437@2|Bacteria,1WJ3D@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	T	PFAM HD domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HD,HD_5,PAS,PAS_3,PAS_4,PAS_9
REGS1_k127_6575449_7	1504672.669783783	8.736e-52	193.0	COG0265@1|root,COG0265@2|Bacteria,1QWA4@1224|Proteobacteria,2VK6X@28216|Betaproteobacteria,4A9X2@80864|Comamonadaceae	28216|Betaproteobacteria	O	peptidase S1 and S6, chymotrypsin Hap	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin_2
REGS1_k127_6575449_0	1535287.JP74_09395	3.187e-149	479.0	COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,2TR0T@28211|Alphaproteobacteria,3N6FK@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	ATPase AAA	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
REGS1_k127_6575449_3	1535287.JP74_09390	3.029e-107	358.0	COG1721@1|root,COG1721@2|Bacteria,1MWPG@1224|Proteobacteria,2TTDX@28211|Alphaproteobacteria,3N7PV@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function DUF58	MA20_44650	-	-	-	-	-	-	-	-	-	-	-	DUF58
REGS1_k127_6575449_4	987059.RBXJA2T_01620	2.377e-95	323.0	COG2304@1|root,COG2304@2|Bacteria,1MXQ7@1224|Proteobacteria,2VHRY@28216|Betaproteobacteria,1KKCR@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Von Willebrand factor type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	BatA,VWA,VWA_2
REGS1_k127_6575449_2	485913.Krac_2372	7.907e-122	401.0	2DBVK@1|root,2ZBBH@2|Bacteria,2G7SF@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_66018_1	580327.Tthe_1979	3.88e-20	101.0	COG5542@1|root,COG5542@2|Bacteria,1V7KR@1239|Firmicutes,24IW1@186801|Clostridia,42IGN@68295|Thermoanaerobacterales	186801|Clostridia	S	integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	Mannosyl_trans2,PMT_2
REGS1_k127_66018_0	926569.ANT_11540	2.164e-74	268.0	COG5305@1|root,COG5305@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
REGS1_k127_66018_2	596152.DesU5LDRAFT_1866	6.843e-05	55.0	2AD1R@1|root,312PX@2|Bacteria,1QCNM@1224|Proteobacteria,433DK@68525|delta/epsilon subdivisions,2WY1V@28221|Deltaproteobacteria,2M8UB@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Glycosyltransferase family 87	-	-	-	-	-	-	-	-	-	-	-	-	GT87
REGS1_k127_6602758_1	378806.STAUR_2774	4.383e-84	287.0	COG1506@1|root,COG1506@2|Bacteria,1QWCQ@1224|Proteobacteria	1224|Proteobacteria	E	esterase lipase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3,Abhydrolase_6,Hydrolase_4
REGS1_k127_6602758_5	1173027.Mic7113_6003	8.11e-10	65.0	COG1470@1|root,COG1470@2|Bacteria,1G0CA@1117|Cyanobacteria,1H8AA@1150|Oscillatoriales	1117|Cyanobacteria	S	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_6602758_7	765420.OSCT_2978	2.409e-05	48.0	28VCT@1|root,2ZHFH@2|Bacteria,2GB88@200795|Chloroflexi,377J8@32061|Chloroflexia	32061|Chloroflexia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_6602758_4	765420.OSCT_2692	6.899e-21	98.0	COG1366@1|root,COG2172@1|root,COG1366@2|Bacteria,COG2172@2|Bacteria,2G93H@200795|Chloroflexi,375J3@32061|Chloroflexia	32061|Chloroflexia	T	PFAM Sulfate transporter antisigma-factor antagonist STAS	-	-	2.7.11.1	ko:K04749,ko:K04757	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	HATPase_c_2,STAS
REGS1_k127_6602758_8	1499967.BAYZ01000017_gene6241	0.0003596	49.0	COG1366@1|root,COG1366@2|Bacteria	2|Bacteria	T	antisigma factor binding	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS
REGS1_k127_6602758_0	1173263.Syn7502_01686	1.345e-89	310.0	COG2199@1|root,COG2208@1|root,COG2208@2|Bacteria,COG3706@2|Bacteria,1G3MK@1117|Cyanobacteria,1GZ7I@1129|Synechococcus	1117|Cyanobacteria	T	Serine phosphatase RsbU, regulator of sigma subunit	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HisKA,Response_reg,SpoIIE
REGS1_k127_6602758_3	1303518.CCALI_02500	4.739e-22	102.0	COG0154@1|root,COG0154@2|Bacteria	2|Bacteria	J	amidase activity	-	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
REGS1_k127_6602758_6	234267.Acid_7160	7.13e-07	53.0	COG0154@1|root,COG0154@2|Bacteria,3Y6WA@57723|Acidobacteria	57723|Acidobacteria	J	Amidase	-	-	-	-	-	-	-	-	-	-	-	-	Amidase
REGS1_k127_6602758_2	1303518.CCALI_02500	5.279e-67	230.0	COG0154@1|root,COG0154@2|Bacteria	2|Bacteria	J	amidase activity	-	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
REGS1_k127_660929_1	926569.ANT_00140	1.292e-31	128.0	COG1959@1|root,COG1959@2|Bacteria,2G8ZH@200795|Chloroflexi	200795|Chloroflexi	K	transcriptional regulator, Rrf2 family	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
REGS1_k127_660929_0	1121472.AQWN01000006_gene1827	2.462e-163	532.0	COG1148@1|root,COG1249@1|root,COG1148@2|Bacteria,COG1249@2|Bacteria,1V5YJ@1239|Firmicutes,248CC@186801|Clostridia,2641A@186807|Peptococcaceae	186801|Clostridia	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Pyr_redox_2
REGS1_k127_6619217_7	861299.J421_0074	2.068e-15	82.0	COG0708@1|root,COG0708@2|Bacteria	2|Bacteria	L	double-stranded DNA 3'-5' exodeoxyribonuclease activity	-	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
REGS1_k127_6619217_3	926550.CLDAP_05310	1.408e-71	252.0	COG1319@1|root,COG1319@2|Bacteria,2G8QC@200795|Chloroflexi	200795|Chloroflexi	C	CO dehydrogenase flavoprotein C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	CO_deh_flav_C,FAD_binding_5
REGS1_k127_6619217_9	420324.KI912019_gene9037	4.154e-06	53.0	COG3845@1|root,COG3845@2|Bacteria,1NT0H@1224|Proteobacteria,2UPJ8@28211|Alphaproteobacteria,1JS62@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	PFAM ABC transporter	rbsA4	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
REGS1_k127_6619217_1	926569.ANT_04690	5.408e-140	451.0	COG1079@1|root,COG1079@2|Bacteria,2G6CY@200795|Chloroflexi	200795|Chloroflexi	S	Branched-chain amino acid transport system / permease component	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
REGS1_k127_6619217_2	926569.ANT_04700	1.799e-136	444.0	COG4603@1|root,COG4603@2|Bacteria,2G686@200795|Chloroflexi	200795|Chloroflexi	S	Branched-chain amino acid transport system / permease component	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
REGS1_k127_6619217_6	1266925.JHVX01000012_gene1688	2.316e-20	93.0	COG3360@1|root,COG3360@2|Bacteria,1PW6C@1224|Proteobacteria,2VXDE@28216|Betaproteobacteria,373H6@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Dodecin	-	-	-	ko:K09165	-	-	-	-	ko00000	-	-	-	Dodecin
REGS1_k127_6619217_8	1121019.AUMN01000013_gene4019	4.776e-13	71.0	COG5552@1|root,COG5552@2|Bacteria,2IQKN@201174|Actinobacteria	201174|Actinobacteria	S	Uncharacterized conserved protein (DUF2277)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2277
REGS1_k127_6619217_5	867845.KI911784_gene2346	8.836e-23	101.0	COG2127@1|root,COG2127@2|Bacteria,2G9F8@200795|Chloroflexi,375WT@32061|Chloroflexia	32061|Chloroflexia	S	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation	clpS	-	-	ko:K06891	-	-	-	-	ko00000	-	-	-	ClpS
REGS1_k127_6619217_0	926569.ANT_04710	2.546e-186	595.0	COG3845@1|root,COG3845@2|Bacteria,2G68B@200795|Chloroflexi	200795|Chloroflexi	S	ATPases associated with a variety of cellular activities	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
REGS1_k127_6619217_4	926569.ANT_04720	5.094e-68	236.0	COG1744@1|root,COG1744@2|Bacteria,2G6CN@200795|Chloroflexi	200795|Chloroflexi	M	ABC transporter substrate-binding protein PnrA-like	-	-	-	ko:K02058,ko:K07335	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	Bmp
REGS1_k127_6625132_1	1382356.JQMP01000003_gene2080	1.012e-75	260.0	COG1573@1|root,COG1573@2|Bacteria,2G6BR@200795|Chloroflexi,27XM8@189775|Thermomicrobia	189775|Thermomicrobia	L	Uracil DNA glycosylase superfamily	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
REGS1_k127_6625132_0	273068.TTE1253	6.221e-189	602.0	COG0595@1|root,COG0595@2|Bacteria,1TQ9G@1239|Firmicutes,2488J@186801|Clostridia,42F33@68295|Thermoanaerobacterales	186801|Clostridia	S	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay	rnj	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,RMMBL
REGS1_k127_6632150_1	926569.ANT_30280	9.334e-116	381.0	COG0667@1|root,COG0667@2|Bacteria,2G631@200795|Chloroflexi	200795|Chloroflexi	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
REGS1_k127_6632150_4	1047013.AQSP01000142_gene179	1.582e-41	160.0	COG0494@1|root,COG0494@2|Bacteria,2NQ7Q@2323|unclassified Bacteria	2|Bacteria	L	NUDIX domain	nudL	GO:0003674,GO:0003824,GO:0016787,GO:0016817,GO:0016818	-	-	-	-	-	-	-	-	-	-	NUDIX
REGS1_k127_6632150_2	926550.CLDAP_02240	5.568e-83	283.0	COG1189@1|root,COG1189@2|Bacteria,2G6BX@200795|Chloroflexi	200795|Chloroflexi	J	Ribosomal RNA methyltransferase RrmJ FtsJ	-	-	2.1.1.226,2.1.1.227	ko:K06442	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ,S4
REGS1_k127_6632150_0	926569.ANT_31260	1.54e-164	530.0	COG1109@1|root,COG1109@2|Bacteria,2G5PR@200795|Chloroflexi	200795|Chloroflexi	G	Phosphoglucomutase/phosphomannomutase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
REGS1_k127_6632150_3	1128421.JAGA01000001_gene2034	1.495e-54	203.0	COG0614@1|root,COG0614@2|Bacteria	2|Bacteria	P	abc-type fe3 -hydroxamate transport system, periplasmic component	fecB	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
REGS1_k127_6632150_5	384616.Pisl_0088	7.828e-34	135.0	COG0494@1|root,arCOG01078@2157|Archaea	2157|Archaea	L	COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
REGS1_k127_6632150_6	525904.Tter_0970	2.459e-10	62.0	COG4012@1|root,COG4012@2|Bacteria,2NQGT@2323|unclassified Bacteria	2|Bacteria	S	Putative pyruvate format-lyase activating enzyme (DUF1786)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1786
REGS1_k127_6635329_3	340099.Teth39_1328	3.992e-29	120.0	COG2270@1|root,COG2270@2|Bacteria,1UHZ6@1239|Firmicutes,25E7U@186801|Clostridia,42FVR@68295|Thermoanaerobacterales	186801|Clostridia	S	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
REGS1_k127_6635329_4	646529.Desaci_2662	1.417e-24	104.0	COG0477@1|root,COG2814@2|Bacteria,1TPPY@1239|Firmicutes,247T9@186801|Clostridia,25ZYZ@186807|Peptococcaceae	186801|Clostridia	EGP	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
REGS1_k127_6635329_2	316274.Haur_4650	2.872e-36	145.0	COG1595@1|root,COG1595@2|Bacteria,2G6UE@200795|Chloroflexi,3778F@32061|Chloroflexia	32061|Chloroflexia	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
REGS1_k127_6635329_0	926550.CLDAP_29040	7.775e-86	295.0	COG1090@1|root,COG1090@2|Bacteria,2G69K@200795|Chloroflexi	200795|Chloroflexi	S	NAD-dependent epimerase dehydratase	-	-	-	ko:K07071	-	-	-	-	ko00000	-	-	-	DUF1731,Epimerase
REGS1_k127_6635329_1	357808.RoseRS_2116	8.138e-44	176.0	COG0789@1|root,COG5012@1|root,COG0789@2|Bacteria,COG5012@2|Bacteria,2G6R8@200795|Chloroflexi,375F0@32061|Chloroflexia	32061|Chloroflexia	K	PFAM regulatory protein, MerR	-	-	-	ko:K22491	-	-	-	-	ko00000,ko03000	-	-	-	B12-binding,B12-binding_2,MerR_1
REGS1_k127_6636117_1	926550.CLDAP_01930	1.875e-17	86.0	COG4713@1|root,COG4713@2|Bacteria,2GA9E@200795|Chloroflexi	2|Bacteria	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	DUF2142
REGS1_k127_6636117_0	316274.Haur_1942	1.374e-34	152.0	COG0457@1|root,COG0457@2|Bacteria,2GB3M@200795|Chloroflexi,377UW@32061|Chloroflexia	32061|Chloroflexia	S	Protein of unknown function (DUF2723)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2723
REGS1_k127_6636117_2	926550.CLDAP_33730	7.114e-08	62.0	COG4713@1|root,COG4713@2|Bacteria,2GA9E@200795|Chloroflexi	2|Bacteria	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	DUF2142
REGS1_k127_6641411_1	107636.JQNK01000009_gene2923	8.472e-07	51.0	COG2156@1|root,COG2156@2|Bacteria,1RABG@1224|Proteobacteria,2TSQ7@28211|Alphaproteobacteria,36YFK@31993|Methylocystaceae	28211|Alphaproteobacteria	P	K+-transporting ATPase, c chain	kdpC	-	3.6.3.12	ko:K01548	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	-	KdpC
REGS1_k127_6641411_0	456442.Mboo_0444	4.252e-284	883.0	COG2216@1|root,arCOG01577@2157|Archaea,2XVYI@28890|Euryarchaeota,2NAIX@224756|Methanomicrobia	224756|Methanomicrobia	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system	kdpB	-	3.6.3.12	ko:K01547	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	-	E1-E2_ATPase,Hydrolase
REGS1_k127_6642159_6	886293.Sinac_5285	1.942e-97	320.0	COG0719@1|root,COG0719@2|Bacteria,2IXZD@203682|Planctomycetes	203682|Planctomycetes	O	COG0719 ABC-type transport system involved in Fe-S cluster assembly permease component	-	-	-	ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
REGS1_k127_6642159_16	1123054.KB907726_gene3115	5.824e-25	106.0	COG2261@1|root,COG2261@2|Bacteria,1N72Y@1224|Proteobacteria,1SCD4@1236|Gammaproteobacteria,1X1RW@135613|Chromatiales	135613|Chromatiales	S	Transglycosylase associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
REGS1_k127_6642159_2	1382356.JQMP01000003_gene2453	3.195e-121	404.0	COG0719@1|root,COG0719@2|Bacteria,2G5S8@200795|Chloroflexi,27Y27@189775|Thermomicrobia	189775|Thermomicrobia	O	Uncharacterized protein family (UPF0051)	-	-	-	ko:K09015	-	-	-	-	ko00000	-	-	-	UPF0051
REGS1_k127_6642159_1	926550.CLDAP_18370	3.078e-143	458.0	COG2897@1|root,COG2897@2|Bacteria,2G5XI@200795|Chloroflexi	200795|Chloroflexi	P	PFAM Rhodanese domain protein	-	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
REGS1_k127_6642159_12	1382306.JNIM01000001_gene1581	1.204e-37	146.0	COG0822@1|root,COG0822@2|Bacteria,2G6WC@200795|Chloroflexi	200795|Chloroflexi	C	NifU-like N terminal domain	-	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
REGS1_k127_6642159_18	926569.ANT_18000	3.413e-17	86.0	COG2151@1|root,COG2151@2|Bacteria,2G9UF@200795|Chloroflexi	200795|Chloroflexi	S	Pfam:DUF59	-	-	-	-	-	-	-	-	-	-	-	-	FeS_assembly_P
REGS1_k127_6642159_0	926550.CLDAP_20370	5.778e-171	546.0	COG0520@1|root,COG0520@2|Bacteria,2G5T3@200795|Chloroflexi	200795|Chloroflexi	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	-	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
REGS1_k127_6642159_11	309801.trd_0377	2.417e-50	181.0	COG0822@1|root,COG0822@2|Bacteria,2G71H@200795|Chloroflexi,27YGN@189775|Thermomicrobia	189775|Thermomicrobia	C	SUF system FeS assembly protein, NifU family	-	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
REGS1_k127_6642159_14	1379698.RBG1_1C00001G0738	1.984e-26	111.0	COG2146@1|root,COG2146@2|Bacteria,2NQ87@2323|unclassified Bacteria	2|Bacteria	P	Rieske-like [2Fe-2S] domain	-	-	-	ko:K05710	ko00360,ko01120,ko01220,map00360,map01120,map01220	M00545	R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002	-	-	-	FeS_assembly_P,Rieske
REGS1_k127_6642159_20	1496688.ER33_14750	3.077e-10	72.0	COG0500@1|root,COG2226@2|Bacteria,1G2F7@1117|Cyanobacteria	1117|Cyanobacteria	Q	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
REGS1_k127_6642159_5	665571.STHERM_c10490	1.4e-97	350.0	COG1196@1|root,COG1196@2|Bacteria,2J57J@203691|Spirochaetes	203691|Spirochaetes	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N
REGS1_k127_6642159_21	1087481.AGFX01000030_gene300	0.0001477	46.0	COG1408@1|root,COG1408@2|Bacteria,1UU17@1239|Firmicutes,4HC8Q@91061|Bacilli,26UNW@186822|Paenibacillaceae	91061|Bacilli	S	Phosphoesterase	ykuE	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos,Metallophos_2
REGS1_k127_6642159_15	326427.Cagg_2556	3.053e-26	117.0	COG1366@1|root,COG1366@2|Bacteria,2G9DJ@200795|Chloroflexi,375QD@32061|Chloroflexia	32061|Chloroflexia	T	PFAM Sulfate transporter antisigma-factor antagonist STAS	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS_2
REGS1_k127_6642159_17	696281.Desru_2822	1.922e-22	104.0	COG0622@1|root,COG0622@2|Bacteria,1V7VB@1239|Firmicutes,2593B@186801|Clostridia,2628M@186807|Peptococcaceae	186801|Clostridia	S	TIGRFAM phosphoesterase, MJ0936 family	-	-	-	ko:K07095	-	-	-	-	ko00000	-	-	-	Metallophos_2
REGS1_k127_6642159_4	926569.ANT_18090	4.69e-103	343.0	COG0078@1|root,COG0078@2|Bacteria,2G5Z9@200795|Chloroflexi	200795|Chloroflexi	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	-	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
REGS1_k127_6642159_10	926569.ANT_30330	1.91e-50	198.0	COG0457@1|root,COG0457@2|Bacteria,2G73P@200795|Chloroflexi	200795|Chloroflexi	S	PFAM TPR repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_2,TPR_4,TPR_6,TPR_7,TPR_8
REGS1_k127_6642159_7	1382356.JQMP01000004_gene72	3.395e-69	244.0	COG1624@1|root,COG1624@2|Bacteria,2G6J7@200795|Chloroflexi,27XJ7@189775|Thermomicrobia	189775|Thermomicrobia	S	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria	dacA	-	-	-	-	-	-	-	-	-	-	-	DisA_N
REGS1_k127_6642159_13	326427.Cagg_2336	1.121e-35	151.0	COG4856@1|root,COG4856@2|Bacteria,2G75D@200795|Chloroflexi,375MS@32061|Chloroflexia	32061|Chloroflexia	S	PFAM YbbR family protein	-	-	-	-	-	-	-	-	-	-	-	-	YbbR
REGS1_k127_6642159_8	926550.CLDAP_12000	7.216e-67	233.0	COG2344@1|root,COG2344@2|Bacteria,2G6EJ@200795|Chloroflexi	200795|Chloroflexi	K	Modulates transcription in response to changes in cellular NADH NAD( ) redox state	rex	-	-	ko:K01926	-	-	-	-	ko00000,ko03000	-	-	-	CoA_binding,Put_DNA-bind_N
REGS1_k127_6642159_3	37659.JNLN01000001_gene1254	1.779e-107	357.0	COG1131@1|root,COG1131@2|Bacteria,1TQTX@1239|Firmicutes,249W1@186801|Clostridia,36FN8@31979|Clostridiaceae	186801|Clostridia	V	ABC-type multidrug transport system, ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
REGS1_k127_6642159_9	1499689.CCNN01000009_gene2814	5.981e-63	226.0	COG0842@1|root,COG0842@2|Bacteria,1TQ9K@1239|Firmicutes,24C8W@186801|Clostridia,36ID2@31979|Clostridiaceae	186801|Clostridia	V	ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
REGS1_k127_6642159_19	479434.Sthe_0949	7.607e-17	81.0	COG3870@1|root,COG3870@2|Bacteria,2G736@200795|Chloroflexi,27YHY@189775|Thermomicrobia	189775|Thermomicrobia	S	Cyclic-di-AMP receptor	-	-	-	-	-	-	-	-	-	-	-	-	CdAMP_rec
REGS1_k127_6650018_2	78245.Xaut_2824	1.308e-12	78.0	COG4447@1|root,COG4447@2|Bacteria,1ND1J@1224|Proteobacteria,2U0UY@28211|Alphaproteobacteria,3EYKB@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	protein related to plant photosystem II stability assembly factor	-	-	-	-	-	-	-	-	-	-	-	-	BNR,Sortilin-Vps10
REGS1_k127_6650018_0	926550.CLDAP_29640	5.489e-107	364.0	COG3664@1|root,COG3664@2|Bacteria,2GBKT@200795|Chloroflexi	200795|Chloroflexi	G	PFAM glycoside hydrolase family 39	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_6650018_1	926569.ANT_12750	2.07e-100	340.0	COG4277@1|root,COG4277@2|Bacteria,2G5JR@200795|Chloroflexi	200795|Chloroflexi	S	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	HHH_3,Radical_SAM
REGS1_k127_665161_1	479434.Sthe_3410	7.996e-37	142.0	COG0500@1|root,COG2890@1|root,COG2226@2|Bacteria,COG2890@2|Bacteria,2G9F9@200795|Chloroflexi	200795|Chloroflexi	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_665161_0	479434.Sthe_3409	2.963e-216	681.0	COG1032@1|root,COG1032@2|Bacteria,2G6ZI@200795|Chloroflexi	200795|Chloroflexi	C	SMART Elongator protein 3 MiaB NifB	-	-	1.21.98.3	ko:K04034	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R06268,R06269,R06270	RC00741,RC01491,RC01492	ko00000,ko00001,ko01000	-	-	-	B12-binding,Radical_SAM
REGS1_k127_6681572_2	690850.Desaf_2331	9.024e-14	72.0	COG3335@1|root,COG3335@2|Bacteria,1P76X@1224|Proteobacteria,433G7@68525|delta/epsilon subdivisions,2WXN9@28221|Deltaproteobacteria,2MF0Q@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	manually curated	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_23
REGS1_k127_6681572_1	1089545.KB913037_gene7859	1.318e-73	256.0	COG0428@1|root,COG0428@2|Bacteria,2IBHZ@201174|Actinobacteria,4E2MD@85010|Pseudonocardiales	201174|Actinobacteria	P	ZIP Zinc transporter	-	-	-	ko:K07238	-	-	-	-	ko00000,ko02000	2.A.5.5	-	-	Zip
REGS1_k127_6681572_0	370438.PTH_2214	3.585e-142	465.0	COG0469@1|root,COG0469@2|Bacteria,1TPGG@1239|Firmicutes,2489V@186801|Clostridia,260WY@186807|Peptococcaceae	186801|Clostridia	G	Belongs to the pyruvate kinase family	pyk	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PEP-utilizers,PK,PK_C
REGS1_k127_6681687_10	690850.Desaf_2331	6.565e-14	72.0	COG3335@1|root,COG3335@2|Bacteria,1P76X@1224|Proteobacteria,433G7@68525|delta/epsilon subdivisions,2WXN9@28221|Deltaproteobacteria,2MF0Q@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	manually curated	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_23
REGS1_k127_6681687_5	525904.Tter_1673	1.908e-57	203.0	COG2185@1|root,COG2185@2|Bacteria,2NPGA@2323|unclassified Bacteria	2|Bacteria	I	Cobalamin B12-binding	-	-	5.4.99.2	ko:K01849	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding
REGS1_k127_6681687_2	765420.OSCT_1738	2.931e-88	301.0	COG1703@1|root,COG1703@2|Bacteria,2G670@200795|Chloroflexi,3751X@32061|Chloroflexia	32061|Chloroflexia	E	TIGRFAM LAO AO transport system ATPase	-	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK
REGS1_k127_6681687_9	429009.Adeg_1465	1.613e-36	145.0	COG0406@1|root,COG0406@2|Bacteria,1V6ES@1239|Firmicutes,24JDV@186801|Clostridia,42G0T@68295|Thermoanaerobacterales	186801|Clostridia	G	PFAM Phosphoglycerate mutase	pspA	-	3.1.3.3,3.1.3.73	ko:K02226,ko:K22305	ko00260,ko00680,ko00860,ko01100,ko01120,ko01130,map00260,map00680,map00860,map01100,map01120,map01130	M00122	R00582,R04594,R11173	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
REGS1_k127_6681687_8	1382306.JNIM01000001_gene3962	1.285e-41	167.0	COG0652@1|root,COG0652@2|Bacteria,2G6RE@200795|Chloroflexi	200795|Chloroflexi	M	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	-	-	5.2.1.8	ko:K01802,ko:K03768	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Pro_isomerase
REGS1_k127_6681687_1	479434.Sthe_2214	6.539e-102	342.0	COG0462@1|root,COG0462@2|Bacteria,2G5T8@200795|Chloroflexi,27Y4E@189775|Thermomicrobia	189775|Thermomicrobia	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	-	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
REGS1_k127_6681687_0	1382356.JQMP01000003_gene2474	1.028e-308	972.0	COG0653@1|root,COG0653@2|Bacteria,2G603@200795|Chloroflexi,27XJU@189775|Thermomicrobia	189775|Thermomicrobia	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
REGS1_k127_6681687_11	469383.Cwoe_0994	6.11e-08	63.0	arCOG06048@1|root,31EJQ@2|Bacteria,2GPSC@201174|Actinobacteria,4CQDB@84995|Rubrobacteria	84995|Rubrobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_6681687_3	1120950.KB892709_gene4036	1.252e-75	263.0	COG1215@1|root,COG1215@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
REGS1_k127_6681687_4	1041930.Mtc_0609	2.476e-67	240.0	COG1216@1|root,arCOG01383@2157|Archaea,2XW51@28890|Euryarchaeota,2N9HF@224756|Methanomicrobia	224756|Methanomicrobia	M	Glycosyl transferase family group 2	-	-	-	ko:K07011	-	-	-	-	ko00000	-	-	-	Glycos_transf_2
REGS1_k127_6681687_6	1128421.JAGA01000002_gene1417	2.277e-53	195.0	COG2178@1|root,COG2178@2|Bacteria,2NR1U@2323|unclassified Bacteria	2|Bacteria	J	PFAM Translin	-	-	-	ko:K07477	-	-	-	-	ko00000	-	-	-	-
REGS1_k127_6681687_7	335543.Sfum_1996	1.108e-48	182.0	COG1355@1|root,COG2078@1|root,COG1355@2|Bacteria,COG2078@2|Bacteria,1MXK5@1224|Proteobacteria,42R55@68525|delta/epsilon subdivisions,2WN4E@28221|Deltaproteobacteria,2MQCK@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Memo-like protein	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
REGS1_k127_6713669_0	926550.CLDAP_38200	0.0	1136.0	COG0086@1|root,COG0086@2|Bacteria,2G632@200795|Chloroflexi	200795|Chloroflexi	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
REGS1_k127_672130_11	1125863.JAFN01000001_gene2311	2.499e-59	215.0	COG0215@1|root,COG0215@2|Bacteria	2|Bacteria	J	cysteine-tRNA ligase activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S51
REGS1_k127_672130_3	926550.CLDAP_29300	1.918e-89	302.0	COG0388@1|root,COG0388@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
REGS1_k127_672130_2	335543.Sfum_0699	3.247e-129	422.0	COG2008@1|root,COG2008@2|Bacteria,1MWCR@1224|Proteobacteria,42MZS@68525|delta/epsilon subdivisions,2WIQP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	aromatic amino acid beta-eliminating lyase threonine aldolase	ltaA	-	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	-	R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
REGS1_k127_672130_9	1122604.JONR01000014_gene215	8.064e-60	214.0	COG2808@1|root,COG2808@2|Bacteria,1N1B9@1224|Proteobacteria,1S7MT@1236|Gammaproteobacteria,1X6HS@135614|Xanthomonadales	135614|Xanthomonadales	K	transcriptional regulator	paiB	-	-	ko:K07734	-	-	-	-	ko00000,ko03000	-	-	-	FMN_bind_2
REGS1_k127_672130_5	485913.Krac_1241	4.822e-84	288.0	COG2141@1|root,COG2141@2|Bacteria	2|Bacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
REGS1_k127_672130_6	574087.Acear_0432	1.544e-70	253.0	COG0644@1|root,COG0644@2|Bacteria,1TRRU@1239|Firmicutes,24BZ3@186801|Clostridia	186801|Clostridia	C	TIGRFAM geranylgeranyl reductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
REGS1_k127_672130_14	1121377.KB906401_gene3385	1.46e-47	181.0	29YCS@1|root,30K75@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_672130_16	1382306.JNIM01000001_gene3919	2.309e-37	149.0	COG2197@1|root,COG2197@2|Bacteria,2G6JC@200795|Chloroflexi	200795|Chloroflexi	K	Two component transcriptional regulator, LuxR family	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
REGS1_k127_672130_19	1382306.JNIM01000001_gene780	1.191e-15	83.0	2DN66@1|root,32VSD@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF664)	-	-	-	-	-	-	-	-	-	-	-	-	DUF664
REGS1_k127_672130_10	595536.ADVE02000001_gene199	1.828e-59	214.0	COG2890@1|root,COG2890@2|Bacteria,1QW4Z@1224|Proteobacteria,2U65C@28211|Alphaproteobacteria,36ZBZ@31993|Methylocystaceae	28211|Alphaproteobacteria	J	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23
REGS1_k127_672130_8	330214.NIDE3554	2.842e-63	226.0	COG0596@1|root,COG0596@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on ester bonds	pcaD	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4
REGS1_k127_672130_0	926550.CLDAP_38260	2.463e-243	773.0	COG0507@1|root,COG0632@1|root,COG0507@2|Bacteria,COG0632@2|Bacteria,2G626@200795|Chloroflexi	200795|Chloroflexi	L	DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity	recD2	-	3.1.11.5	ko:K03581	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_30,HHH_4,HHH_5,UvrD_C_2
REGS1_k127_672130_1	485913.Krac_3483	4.07e-136	445.0	COG0520@1|root,COG0520@2|Bacteria,2G62I@200795|Chloroflexi	200795|Chloroflexi	E	PFAM aminotransferase class V	-	-	5.1.1.17	ko:K04127	ko00311,ko01100,ko01130,map00311,map01100,map01130	M00673	R04147	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	Aminotran_5
REGS1_k127_672130_22	357808.RoseRS_4623	8.939e-06	58.0	COG3063@1|root,COG3063@2|Bacteria	2|Bacteria	NU	photosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	ANAPC5,Peptidase_C39_2,Rhomboid,TPR_16,TPR_19,TPR_8
REGS1_k127_672130_17	96561.Dole_1891	7.001e-30	129.0	COG0454@1|root,COG1181@1|root,COG0456@2|Bacteria,COG1181@2|Bacteria,1N4F5@1224|Proteobacteria,42NYM@68525|delta/epsilon subdivisions,2WKTX@28221|Deltaproteobacteria,2MHWK@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Belongs to the D-alanine--D-alanine ligase family	ddlB1	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
REGS1_k127_672130_7	1232410.KI421421_gene3683	1.826e-68	246.0	COG1181@1|root,COG1181@2|Bacteria,1N4F5@1224|Proteobacteria,42NYM@68525|delta/epsilon subdivisions,2WKTX@28221|Deltaproteobacteria,43U6N@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	ATP-grasp domain	-	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
REGS1_k127_672130_15	1157490.EL26_04445	6.372e-40	158.0	COG1994@1|root,COG1994@2|Bacteria,1V6D4@1239|Firmicutes,4HK6C@91061|Bacilli,278I8@186823|Alicyclobacillaceae	91061|Bacilli	S	Peptidase family M50	ywhC	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
REGS1_k127_672130_21	926550.CLDAP_05880	1.337e-06	61.0	COG3103@1|root,COG4991@2|Bacteria	2|Bacteria	T	sh3 domain protein	-	-	3.5.1.28	ko:K01447	-	-	R04112	RC00064,RC00141	ko00000,ko01000	-	-	-	DUF4366,Glyco_hydro_99,SH3_3
REGS1_k127_672130_20	397945.Aave_3406	7.897e-13	81.0	COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,2VH9R@28216|Betaproteobacteria,4A9JN@80864|Comamonadaceae	28216|Betaproteobacteria	U	Involved in the TonB-independent uptake of proteins	tolB	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40,TolB_N
REGS1_k127_672130_13	479434.Sthe_0803	5.243e-48	184.0	COG0287@1|root,COG0287@2|Bacteria,2G6BW@200795|Chloroflexi,27XQX@189775|Thermomicrobia	189775|Thermomicrobia	C	Prephenate dehydrogenase	-	-	1.3.1.12	ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025	R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	PDH
REGS1_k127_672130_12	1298593.TOL_2207	1.671e-57	208.0	COG1215@1|root,COG1215@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
REGS1_k127_672130_18	393480.FNP_0541	1.644e-20	95.0	COG3774@1|root,COG3774@2|Bacteria,379NV@32066|Fusobacteria	32066|Fusobacteria	M	Psort location Cytoplasmic, score 8.96	-	-	-	-	-	-	-	-	-	-	-	-	Gb3_synth,Gly_transf_sug
REGS1_k127_672130_4	926550.CLDAP_02150	3.454e-84	286.0	COG0438@1|root,COG0438@2|Bacteria,2G67A@200795|Chloroflexi	200795|Chloroflexi	M	PFAM glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
REGS1_k127_6721603_3	1537715.JQFJ01000002_gene435	4.824e-08	56.0	COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,2TRFZ@28211|Alphaproteobacteria,2K0QB@204457|Sphingomonadales	204457|Sphingomonadales	T	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	phoB	-	-	ko:K07657	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
REGS1_k127_6721603_0	357808.RoseRS_3083	2.634e-139	459.0	COG0154@1|root,COG0154@2|Bacteria,2G7S4@200795|Chloroflexi,377YI@32061|Chloroflexia	32061|Chloroflexia	J	Belongs to the amidase family	-	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
REGS1_k127_6721603_2	926569.ANT_04320	1.095e-68	246.0	COG0491@1|root,COG0491@2|Bacteria,2G8XN@200795|Chloroflexi	200795|Chloroflexi	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
REGS1_k127_6721603_1	309801.trd_1461	3.761e-89	305.0	COG3804@1|root,COG3804@2|Bacteria,2GA3D@200795|Chloroflexi,27YZV@189775|Thermomicrobia	189775|Thermomicrobia	S	Dihydrodipicolinate reductase, N-terminus	-	-	1.4.1.12,1.4.1.26	ko:K21672	ko00310,ko00330,ko00472,map00310,map00330,map00472	-	R02825,R04200,R04201,R04687,R04688	RC00249,RC00790	ko00000,ko00001,ko01000	-	-	-	DapB_N
REGS1_k127_6750926_2	926550.CLDAP_25270	4.291e-15	76.0	COG1032@1|root,COG1032@2|Bacteria,2G6X0@200795|Chloroflexi	200795|Chloroflexi	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4070,Radical_SAM
REGS1_k127_6750926_0	926550.CLDAP_25270	1.385e-170	546.0	COG1032@1|root,COG1032@2|Bacteria,2G6X0@200795|Chloroflexi	200795|Chloroflexi	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4070,Radical_SAM
REGS1_k127_6750926_1	929712.KI912613_gene1421	7.694e-35	147.0	COG3268@1|root,COG3268@2|Bacteria,2GMKU@201174|Actinobacteria,4CSJP@84995|Rubrobacteria	84995|Rubrobacteria	S	Saccharopine dehydrogenase NADP binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Sacchrp_dh_NADP
REGS1_k127_6750926_3	933115.GPDM_12886	2.757e-10	72.0	COG0726@1|root,COG1388@1|root,COG0726@2|Bacteria,COG1388@2|Bacteria,1UZ7Q@1239|Firmicutes,4IPRX@91061|Bacilli,26FMM@186818|Planococcaceae	91061|Bacilli	GM	chitin deacetylase	-	-	3.5.1.104	ko:K22278	-	-	-	-	ko00000,ko01000	-	-	-	LysM,Polysacc_deac_1
REGS1_k127_6770985_3	357808.RoseRS_2166	9.519e-29	115.0	COG0714@1|root,COG0714@2|Bacteria,2G5WI@200795|Chloroflexi,37710@32061|Chloroflexia	32061|Chloroflexia	S	PFAM ATPase associated with various cellular activities, AAA_5	-	-	-	-	-	-	-	-	-	-	-	-	AAA_5
REGS1_k127_6770985_2	1122221.JHVI01000005_gene596	2.392e-83	280.0	COG0714@1|root,COG0714@2|Bacteria,1WKZZ@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	AAA domain (dynein-related subfamily)	-	-	-	-	-	-	-	-	-	-	-	-	AAA_5
REGS1_k127_6770985_0	383372.Rcas_1453	5.205e-105	361.0	COG3552@1|root,COG3552@2|Bacteria,2G5IW@200795|Chloroflexi,3769V@32061|Chloroflexia	32061|Chloroflexia	S	SMART von Willebrand factor, type A	-	-	-	ko:K07161	-	-	-	-	ko00000	-	-	-	VWA_CoxE
REGS1_k127_6770985_1	1382306.JNIM01000001_gene3511	2.125e-98	336.0	COG0635@1|root,COG0635@2|Bacteria,2G5NK@200795|Chloroflexi	200795|Chloroflexi	H	Involved in the biosynthesis of porphyrin-containing compound	hemN	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
REGS1_k127_6770985_4	1278073.MYSTI_00901	6.597e-21	93.0	COG2382@1|root,COG2382@2|Bacteria,1QX4D@1224|Proteobacteria	1224|Proteobacteria	P	Putative esterase	-	-	-	ko:K07214	-	-	-	-	ko00000	-	-	-	Esterase
REGS1_k127_6783573_0	926550.CLDAP_22720	6.252e-68	254.0	COG0451@1|root,COG0451@2|Bacteria,2G74B@200795|Chloroflexi	200795|Chloroflexi	GM	Protein of unknown function (DUF4012)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4012
REGS1_k127_6826497_4	1303518.CCALI_01986	1.079e-29	124.0	COG3605@1|root,COG3920@1|root,COG3605@2|Bacteria,COG3920@2|Bacteria	2|Bacteria	T	Histidine kinase	pdtaS	-	2.1.1.80,2.7.13.3,3.1.1.61,3.1.4.52,3.6.3.17,4.2.1.75,4.6.1.1	ko:K00936,ko:K01719,ko:K01768,ko:K02030,ko:K02584,ko:K10441,ko:K13924,ko:K20962	ko00230,ko00860,ko01100,ko01110,ko01120,ko02010,ko02020,ko02025,ko02030,ko04113,ko04213,ko05111,map00230,map00860,map01100,map01110,map01120,map02010,map02020,map02025,map02030,map04113,map04213,map05111	M00121,M00212,M00236,M00506,M00695,M00839	R00089,R00434,R03165	RC00295,RC01861	ko00000,ko00001,ko00002,ko01000,ko01001,ko02000,ko02022,ko02035,ko03000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19,3.A.1.3	-	-	GAF,GAF_2,HATPase_c,HATPase_c_2,H_kinase_N,HisKA_2,PAS,PAS_3,PAS_4,PAS_9,Response_reg,TPR_12,TPR_8
REGS1_k127_6826497_3	1410618.JNKI01000015_gene1584	4.036e-48	181.0	COG3707@1|root,COG3707@2|Bacteria,1U6TA@1239|Firmicutes,4H1ZW@909932|Negativicutes	909932|Negativicutes	T	Response regulator receiver domain protein	pdtaR	-	-	ko:K22010	-	M00839	-	-	ko00000,ko00002,ko02022	-	-	-	ANTAR,Response_reg
REGS1_k127_6826497_0	357808.RoseRS_0065	8.392e-112	372.0	COG5621@1|root,COG5621@2|Bacteria,2G6EI@200795|Chloroflexi,374YJ@32061|Chloroflexia	32061|Chloroflexia	S	Lipocalin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CrtC,Lipocalin_9
REGS1_k127_6826497_2	329726.AM1_5602	2.784e-52	192.0	COG0577@1|root,COG0577@2|Bacteria,1G04T@1117|Cyanobacteria	1117|Cyanobacteria	V	ABC-type transport system involved in lipoprotein release permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
REGS1_k127_6826497_1	867845.KI911784_gene3377	2.521e-55	205.0	COG0577@1|root,COG0577@2|Bacteria,2G6IW@200795|Chloroflexi,374ZQ@32061|Chloroflexia	32061|Chloroflexia	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
REGS1_k127_6844745_3	204669.Acid345_1849	8.217e-09	56.0	COG0624@1|root,COG0624@2|Bacteria,3Y3TZ@57723|Acidobacteria,2JIUW@204432|Acidobacteriia	204432|Acidobacteriia	E	PFAM peptidase	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
REGS1_k127_6844745_0	1173024.KI912149_gene6518	6.904e-180	593.0	COG0814@1|root,COG0814@2|Bacteria,1G4RP@1117|Cyanobacteria	1117|Cyanobacteria	E	amino acid	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_6844745_2	1237500.ANBA01000001_gene5051	6.851e-39	154.0	COG0500@1|root,COG0500@2|Bacteria,2GX4K@201174|Actinobacteria,4EN67@85012|Streptosporangiales	201174|Actinobacteria	Q	Thiopurine S-methyltransferase (TPMT)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25,TPMT
REGS1_k127_6844745_1	485913.Krac_11359	2.201e-67	237.0	COG0745@1|root,COG0745@2|Bacteria,2G6JT@200795|Chloroflexi	200795|Chloroflexi	K	Two component transcriptional regulator, winged helix family	-	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
REGS1_k127_6847840_1	264198.Reut_B5441	4.011e-39	151.0	COG0407@1|root,COG0407@2|Bacteria,1NDUE@1224|Proteobacteria,2VZ7U@28216|Betaproteobacteria	28216|Betaproteobacteria	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
REGS1_k127_6847840_0	357808.RoseRS_2403	1.227e-142	461.0	COG0165@1|root,COG0165@2|Bacteria,2G616@200795|Chloroflexi,375AG@32061|Chloroflexia	32061|Chloroflexia	E	PFAM fumarate lyase	argH	GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
REGS1_k127_685275_0	926550.CLDAP_18650	2.374e-176	564.0	COG1032@1|root,COG1032@2|Bacteria,2G6ZI@200795|Chloroflexi	2|Bacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	1.21.98.3	ko:K04034	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R06268,R06269,R06270	RC00741,RC01491,RC01492	ko00000,ko00001,ko01000	-	-	-	B12-binding,Radical_SAM
REGS1_k127_685275_2	604331.AUHY01000048_gene2130	2.273e-39	151.0	COG0517@1|root,COG0517@2|Bacteria,1WMQJ@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	ko:K04767	-	-	-	-	ko00000	-	-	-	CBS
REGS1_k127_685275_4	552811.Dehly_0155	2.043e-31	129.0	COG0589@1|root,COG0589@2|Bacteria,2G91P@200795|Chloroflexi,34DF4@301297|Dehalococcoidia	301297|Dehalococcoidia	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
REGS1_k127_685275_1	926569.ANT_29930	2.397e-102	341.0	COG2116@1|root,COG2116@2|Bacteria,2G967@200795|Chloroflexi	200795|Chloroflexi	P	Formate/nitrite transporter	-	-	-	ko:K06212	-	-	-	-	ko00000,ko02000	1.A.16.1.1,1.A.16.1.3	-	-	Form_Nir_trans
REGS1_k127_685275_3	671143.DAMO_1602	3.658e-32	138.0	COG1814@1|root,COG1814@2|Bacteria,2NPJP@2323|unclassified Bacteria	2|Bacteria	S	VIT family	MA20_19235	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin,VIT1
REGS1_k127_685275_5	926569.ANT_30850	7.724e-14	79.0	COG0694@1|root,COG0694@2|Bacteria	2|Bacteria	O	iron-sulfur cluster assembly	nfuA	-	-	-	-	-	-	-	-	-	-	-	NifU
REGS1_k127_6871479_1	1244869.H261_12211	2.248e-12	69.0	COG1884@1|root,COG1884@2|Bacteria,1MUXX@1224|Proteobacteria,2TQYC@28211|Alphaproteobacteria,2JP9C@204441|Rhodospirillales	204441|Rhodospirillales	I	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly	icmF	-	-	-	-	-	-	-	-	-	-	-	ArgK,B12-binding,MM_CoA_mutase
REGS1_k127_6871479_0	589924.Ferp_2326	2.747e-149	480.0	COG0145@1|root,arCOG01511@2157|Archaea,2XT1J@28890|Euryarchaeota,24788@183980|Archaeoglobi	183980|Archaeoglobi	E	Hydantoinase/oxoprolinase	-	-	3.5.2.14	ko:K01473	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A
REGS1_k127_691976_0	1278073.MYSTI_00252	1.38e-130	427.0	COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,432W6@68525|delta/epsilon subdivisions,2WXSH@28221|Deltaproteobacteria,2Z2XE@29|Myxococcales	28221|Deltaproteobacteria	E	Aminotransferase class-V	-	-	2.6.1.44,2.6.1.45,2.6.1.51	ko:K00830	ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146	M00346,M00532	R00369,R00372,R00585,R00588	RC00006,RC00008,RC00018	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
REGS1_k127_691976_1	926550.CLDAP_15340	7.995e-68	239.0	COG0500@1|root,COG2226@2|Bacteria,2G780@200795|Chloroflexi	200795|Chloroflexi	Q	PFAM Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
REGS1_k127_691976_2	1047013.AQSP01000144_gene832	1.574e-40	156.0	COG1898@1|root,COG1898@2|Bacteria,2NPIP@2323|unclassified Bacteria	2|Bacteria	M	Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose	rfbC	-	5.1.3.13	ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R06514	RC01531	ko00000,ko00001,ko00002,ko01000	-	-	-	dTDP_sugar_isom
REGS1_k127_691976_3	349124.Hhal_0902	2.354e-33	131.0	COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,1RMHQ@1236|Gammaproteobacteria,1WW0I@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
REGS1_k127_6922770_6	880072.Desac_0424	1.089e-22	99.0	2C6B2@1|root,335GA@2|Bacteria,1NG8G@1224|Proteobacteria,42X8T@68525|delta/epsilon subdivisions,2WSSY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_6922770_5	237368.SCABRO_01606	9.977e-43	158.0	2DNRM@1|root,32YT2@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF2442)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2442
REGS1_k127_6922770_3	1121479.AUBS01000001_gene3253	3.189e-50	190.0	COG0600@1|root,COG0600@2|Bacteria,1MVAE@1224|Proteobacteria,2TSP5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	ABC-type nitrate sulfonate bicarbonate transport system permease component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
REGS1_k127_6922770_2	298654.FraEuI1c_5924	7.651e-119	393.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	thiY	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
REGS1_k127_6922770_1	1121272.KB903249_gene1783	1.303e-136	440.0	COG0388@1|root,COG0388@2|Bacteria,2GKRJ@201174|Actinobacteria,4D96X@85008|Micromonosporales	201174|Actinobacteria	S	Carbon-nitrogen hydrolase	-	-	3.5.1.6	ko:K01431	ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100	M00046	R00905,R04666,R08228	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase
REGS1_k127_6922770_0	357808.RoseRS_2594	1.216e-186	594.0	COG1231@1|root,COG1231@2|Bacteria,2G942@200795|Chloroflexi	200795|Chloroflexi	E	PFAM amine oxidase	-	-	1.4.3.4	ko:K00274	ko00260,ko00330,ko00340,ko00350,ko00360,ko00380,ko00950,ko00982,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00260,map00330,map00340,map00350,map00360,map00380,map00950,map00982,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00135	R02173,R02382,R02529,R02532,R02613,R02908,R02919,R04025,R04300,R04674,R04890,R04893,R04894,R04907,R04908,R08346,R08347,R08348,R11354	RC00062,RC00160,RC00225,RC00676,RC00807,RC00808,RC01808,RC02226,RC02713	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
REGS1_k127_6922770_7	1120934.KB894403_gene393	2.083e-15	79.0	COG2346@1|root,COG2346@2|Bacteria,2I95U@201174|Actinobacteria,4ECXX@85010|Pseudonocardiales	201174|Actinobacteria	S	COG2346, Truncated hemoglobins	-	-	-	-	-	-	-	-	-	-	-	-	Bac_globin,Fer4_19,zf-CDGSH
REGS1_k127_6922770_4	215803.DB30_5624	4.314e-48	175.0	COG0044@1|root,COG0044@2|Bacteria,1MW10@1224|Proteobacteria,42PXH@68525|delta/epsilon subdivisions,2WKEX@28221|Deltaproteobacteria,2YTWX@29|Myxococcales	28221|Deltaproteobacteria	F	Amidohydrolase family	-	-	3.5.2.2	ko:K01464	ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100	M00046	R02269,R03055,R08227	RC00632,RC00680	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Amidohydro_1
REGS1_k127_6929949_4	1415166.NONO_c28070	3.552e-11	71.0	2DMMQ@1|root,32SHK@2|Bacteria,2IHWW@201174|Actinobacteria,4G2S5@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF3052
REGS1_k127_6929949_0	926550.CLDAP_19790	1.706e-106	352.0	COG1410@1|root,COG1410@2|Bacteria,2G5Y6@200795|Chloroflexi	200795|Chloroflexi	H	Methionine synthase B12-binding module cap domain protein	-	-	2.1.1.13,2.1.1.258	ko:K00548,ko:K15023	ko00270,ko00450,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01230,map00270,map00450,map00670,map00720,map01100,map01110,map01120,map01200,map01230	M00017,M00377	R00946,R02289,R09365,R10243	RC00004,RC00035,RC00113,RC01144,RC01241,RC02871,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
REGS1_k127_6929949_1	1121382.JQKG01000004_gene4009	9.836e-78	269.0	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	-	-	1.11.1.10	ko:K00433	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_6,Hydrolase_4
REGS1_k127_6929949_3	485915.Dret_1535	2.853e-11	67.0	292Y4@1|root,2ZQFK@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_6929949_2	264732.Moth_1200	2.475e-11	65.0	COG0633@1|root,COG3894@1|root,COG0633@2|Bacteria,COG3894@2|Bacteria,1TP0H@1239|Firmicutes,247S0@186801|Clostridia,42F3G@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
REGS1_k127_693770_3	926550.CLDAP_14690	2.906e-54	206.0	COG0739@1|root,COG1388@1|root,COG0739@2|Bacteria,COG1388@2|Bacteria,2G901@200795|Chloroflexi	200795|Chloroflexi	M	Lysin motif	-	-	-	-	-	-	-	-	-	-	-	-	LysM,Peptidase_M23
REGS1_k127_693770_6	1307436.PBF_19663	3.238e-09	67.0	2ECUP@1|root,30E8S@2|Bacteria,1UC99@1239|Firmicutes,4I1Z5@91061|Bacilli,1ZNUE@1386|Bacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_693770_0	1499967.BAYZ01000196_gene3073	1.614e-147	479.0	COG2379@1|root,COG2379@2|Bacteria,2NNQP@2323|unclassified Bacteria	2|Bacteria	G	MOFRL family	ttuD	-	2.7.1.165	ko:K11529	ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200	M00346	R08572	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4147,MOFRL
REGS1_k127_693770_7	1273125.Rrhod_2285	5.333e-09	67.0	COG1075@1|root,COG1075@2|Bacteria,2GM7V@201174|Actinobacteria,4FWJW@85025|Nocardiaceae	201174|Actinobacteria	S	Lipase (class 2)	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Hydrolase_4,Lipase_2
REGS1_k127_693770_1	357808.RoseRS_3334	2.313e-91	316.0	COG0324@1|root,COG0324@2|Bacteria,2G5S7@200795|Chloroflexi,374TE@32061|Chloroflexia	32061|Chloroflexia	J	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
REGS1_k127_693770_4	1382306.JNIM01000001_gene1260	4.871e-30	124.0	COG0792@1|root,COG0792@2|Bacteria,2G7AR@200795|Chloroflexi	200795|Chloroflexi	L	Belongs to the UPF0102 family	-	-	-	ko:K07460	-	-	-	-	ko00000	-	-	-	UPF0102
REGS1_k127_693770_5	765911.Thivi_4301	1.197e-16	87.0	COG0484@1|root,COG0484@2|Bacteria,1N16C@1224|Proteobacteria,1SDQK@1236|Gammaproteobacteria,1X1AZ@135613|Chromatiales	135613|Chromatiales	O	DnaJ molecular chaperone homology domain	-	-	-	-	-	-	-	-	-	-	-	-	DnaJ
REGS1_k127_693770_2	926550.CLDAP_39310	5.919e-58	207.0	COG2220@1|root,COG2220@2|Bacteria,2G6IQ@200795|Chloroflexi	200795|Chloroflexi	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
REGS1_k127_6938432_4	1304880.JAGB01000001_gene962	2.379e-21	98.0	COG0079@1|root,COG0079@2|Bacteria,1TPUV@1239|Firmicutes,24837@186801|Clostridia	186801|Clostridia	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
REGS1_k127_6938432_0	1125863.JAFN01000001_gene1231	6.315e-134	440.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,42QAD@68525|delta/epsilon subdivisions,2WK5V@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
REGS1_k127_6938432_1	589924.Ferp_2329	2.709e-119	394.0	COG1960@1|root,arCOG01707@2157|Archaea,2XT5S@28890|Euryarchaeota	28890|Euryarchaeota	I	COG1960 Acyl-CoA dehydrogenases	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
REGS1_k127_6938432_2	767817.Desgi_1135	1.198e-47	181.0	COG2030@1|root,COG2030@2|Bacteria,1VE44@1239|Firmicutes,24SWZ@186801|Clostridia	186801|Clostridia	I	N-terminal half of MaoC dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
REGS1_k127_6938432_3	767817.Desgi_1150	2.475e-29	121.0	COG1028@1|root,COG1028@2|Bacteria,1TPIK@1239|Firmicutes,25073@186801|Clostridia	186801|Clostridia	IQ	Psort location Cytoplasmic, score	fabG2	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
REGS1_k127_6938557_2	1190603.AJYD01000003_gene4353	5.879e-43	164.0	COG3714@1|root,COG3714@2|Bacteria,1PN0I@1224|Proteobacteria,1RNUV@1236|Gammaproteobacteria,1Y26V@135623|Vibrionales	135623|Vibrionales	S	YhhN family	-	-	-	-	-	-	-	-	-	-	-	-	YhhN
REGS1_k127_6938557_1	684949.ATTJ01000001_gene903	1.328e-71	248.0	COG2197@1|root,COG2197@2|Bacteria,1WI4W@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	T	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
REGS1_k127_6938557_0	926554.KI912635_gene2966	6.179e-94	319.0	COG4585@1|root,COG4585@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE2,HATPase_c,HisKA_3
REGS1_k127_6971637_3	1382306.JNIM01000001_gene3396	8.883e-59	205.0	COG2987@1|root,COG2987@2|Bacteria,2G5PQ@200795|Chloroflexi	200795|Chloroflexi	E	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate	hutU	-	4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000	-	-	-	Urocanase,Urocanase_C,Urocanase_N
REGS1_k127_6971637_2	1303518.CCALI_00707	7.375e-61	215.0	COG2316@1|root,COG2316@2|Bacteria	2|Bacteria	J	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K06951	-	-	-	-	ko00000	-	-	-	HD
REGS1_k127_6971637_0	765420.OSCT_2193	5.04e-86	299.0	COG1195@1|root,COG1195@2|Bacteria,2G60N@200795|Chloroflexi,375E0@32061|Chloroflexia	32061|Chloroflexia	L	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP	recF	GO:0000731,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:1901360,GO:1901362,GO:1901576	-	ko:K03629	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	SMC_N
REGS1_k127_6971637_1	926550.CLDAP_37010	2.775e-61	220.0	COG0500@1|root,COG2226@2|Bacteria,2G6GD@200795|Chloroflexi	200795|Chloroflexi	Q	Methyltransferase type 11	-	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_31
REGS1_k127_6971637_5	1265505.ATUG01000001_gene4389	1.98e-39	153.0	COG1595@1|root,COG1595@2|Bacteria,1PEU8@1224|Proteobacteria,42T76@68525|delta/epsilon subdivisions,2WPVH@28221|Deltaproteobacteria,2MM35@213118|Desulfobacterales	28221|Deltaproteobacteria	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
REGS1_k127_6971637_4	485913.Krac_7364	5.393e-46	173.0	COG1595@1|root,COG1595@2|Bacteria,2G93G@200795|Chloroflexi	200795|Chloroflexi	K	RNA polymerase, sigma-24 subunit, ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
REGS1_k127_6971648_1	411463.EUBVEN_02711	3.048e-110	371.0	COG0777@1|root,COG0825@1|root,COG0777@2|Bacteria,COG0825@2|Bacteria,1TP4U@1239|Firmicutes,248QK@186801|Clostridia,25V1B@186806|Eubacteriaceae	186801|Clostridia	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA	accD	-	2.1.3.15,6.4.1.2	ko:K01962,ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS20740	ACCA,Carboxyl_trans
REGS1_k127_6971648_4	661478.OP10G_2684	1.352e-16	90.0	COG3420@1|root,COG3420@2|Bacteria	2|Bacteria	P	alginic acid biosynthetic process	quiC	-	4.2.1.118	ko:K09483	ko00400,ko01110,ko01130,map00400,map01110,map01130	-	R01627	RC00568	ko00000,ko00001,ko01000	-	-	-	Beta_helix,CHU_C,NosD
REGS1_k127_6971648_3	401526.TcarDRAFT_0666	1.669e-46	171.0	COG0251@1|root,COG0251@2|Bacteria,1V6HG@1239|Firmicutes,4H4UD@909932|Negativicutes	909932|Negativicutes	J	Endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
REGS1_k127_6971648_2	1128421.JAGA01000002_gene455	1.628e-105	357.0	COG0539@1|root,COG0539@2|Bacteria,2NNTP@2323|unclassified Bacteria	2|Bacteria	J	Ribosomal protein S1	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
REGS1_k127_6971648_0	926569.ANT_04530	1.442e-198	631.0	COG0542@1|root,COG0542@2|Bacteria,2G5RA@200795|Chloroflexi	200795|Chloroflexi	O	ATPase AAA-2 domain protein	clpC	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,HTH_17,UVR
REGS1_k127_698922_2	1382306.JNIM01000001_gene1020	2.817e-21	98.0	2DNAS@1|root,32WH6@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Phi_1
REGS1_k127_698922_1	926550.CLDAP_00400	4.595e-25	111.0	COG1051@1|root,COG1051@2|Bacteria,2G77J@200795|Chloroflexi	200795|Chloroflexi	F	Nudix hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
REGS1_k127_698922_0	525904.Tter_0977	0.0	1215.0	COG0060@1|root,COG0060@2|Bacteria,2NNT5@2323|unclassified Bacteria	2|Bacteria	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iG2583_1286.G2583_0027,iPC815.YPO0475	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
REGS1_k127_7004305_17	324602.Caur_3100	4.048e-12	67.0	COG0494@1|root,COG0494@2|Bacteria	2|Bacteria	L	nUDIX hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
REGS1_k127_7004305_12	485913.Krac_5452	6.379e-35	136.0	2CWCM@1|root,32SZF@2|Bacteria,2G973@200795|Chloroflexi	200795|Chloroflexi	S	Domain of unknown function (DUF4260)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4260
REGS1_k127_7004305_8	1382306.JNIM01000001_gene2020	1.886e-51	192.0	2BBY6@1|root,325GN@2|Bacteria,2G746@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_7004305_13	1173026.Glo7428_4200	1.258e-27	120.0	COG2199@1|root,COG2202@1|root,COG2202@2|Bacteria,COG3706@2|Bacteria,1FZWU@1117|Cyanobacteria	1117|Cyanobacteria	T	Diguanylate cyclase with PAS PAC and GAF sensors	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,GAF,GAF_2,GAF_3,GGDEF,PAS,PAS_3,PAS_9
REGS1_k127_7004305_15	316274.Haur_3093	8.009e-14	76.0	COG0745@1|root,COG0745@2|Bacteria	316274.Haur_3093|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_7004305_2	1128421.JAGA01000003_gene3228	1.966e-112	372.0	COG0604@1|root,COG0604@2|Bacteria,2NP5I@2323|unclassified Bacteria	2|Bacteria	C	PFAM Alcohol dehydrogenase, zinc-binding	-	-	1.1.1.1	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
REGS1_k127_7004305_11	1121946.AUAX01000003_gene1447	3.398e-36	149.0	COG2267@1|root,COG2267@2|Bacteria,2IGKW@201174|Actinobacteria,4DIAN@85008|Micromonosporales	201174|Actinobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
REGS1_k127_7004305_10	1128421.JAGA01000002_gene1623	6.275e-41	156.0	COG2606@1|root,COG2606@2|Bacteria	2|Bacteria	S	Cys-tRNA(Pro) hydrolase activity	ybaK	GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0043906,GO:0043907,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360	-	ko:K03976	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_edit
REGS1_k127_7004305_16	1047013.AQSP01000048_gene2214	1.481e-12	78.0	COG1266@1|root,COG1266@2|Bacteria	2|Bacteria	V	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
REGS1_k127_7004305_1	479434.Sthe_0985	3.641e-155	506.0	COG0277@1|root,COG0277@2|Bacteria,2G5TM@200795|Chloroflexi,27XF8@189775|Thermomicrobia	189775|Thermomicrobia	C	FAD linked oxidases, C-terminal domain	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
REGS1_k127_7004305_5	324602.Caur_1144	3.785e-62	232.0	COG0277@1|root,COG0277@2|Bacteria,2G6FW@200795|Chloroflexi	200795|Chloroflexi	C	PFAM FAD linked oxidase domain protein	-	-	-	ko:K11472	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	FAD-oxidase_C,FAD_binding_4
REGS1_k127_7004305_9	765420.OSCT_0641	3.023e-45	172.0	COG4330@1|root,COG4330@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1361)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1361
REGS1_k127_7004305_3	671143.DAMO_3031	1.399e-100	351.0	COG0247@1|root,COG0247@2|Bacteria,2NNU8@2323|unclassified Bacteria	2|Bacteria	C	Cysteine-rich domain	-	-	-	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	CCG,Fer4_17,Fer4_7,Fer4_8
REGS1_k127_7004305_6	1379698.RBG1_1C00001G1027	1.034e-60	216.0	COG0491@1|root,COG0491@2|Bacteria,2NPD5@2323|unclassified Bacteria	2|Bacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
REGS1_k127_7004305_14	479434.Sthe_3414	1.321e-26	121.0	COG1708@1|root,COG1708@2|Bacteria	2|Bacteria	S	nucleotidyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	HEPN,NTP_transf_2,UPF0158
REGS1_k127_7004305_0	479434.Sthe_3413	4.745e-198	628.0	COG1032@1|root,COG1032@2|Bacteria,2G6ZI@200795|Chloroflexi	200795|Chloroflexi	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
REGS1_k127_7004305_4	340.xcc-b100_2583	2.803e-81	278.0	COG0500@1|root,COG2226@2|Bacteria,1QU24@1224|Proteobacteria,1T1MU@1236|Gammaproteobacteria,1XCS8@135614|Xanthomonadales	135614|Xanthomonadales	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
REGS1_k127_7004305_7	479434.Sthe_3410	1.679e-53	199.0	COG0500@1|root,COG2890@1|root,COG2226@2|Bacteria,COG2890@2|Bacteria,2G9F9@200795|Chloroflexi	200795|Chloroflexi	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_7012100_2	589924.Ferp_1758	9.345e-74	258.0	COG0407@1|root,arCOG03323@2157|Archaea,2XV21@28890|Euryarchaeota	28890|Euryarchaeota	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	hemE	-	2.1.1.246,4.1.1.37	ko:K01599,ko:K14080	ko00680,ko00860,ko01100,ko01110,ko01120,ko01200,map00680,map00860,map01100,map01110,map01120,map01200	M00121,M00356	R03197,R04972,R09098,R10000	RC00035,RC00872,RC01144,RC02440	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
REGS1_k127_7012100_3	765420.OSCT_2742	6.956e-63	224.0	COG1262@1|root,COG1262@2|Bacteria	2|Bacteria	T	PFAM Formylglycine-generating sulfatase enzyme	-	-	1.14.99.50	ko:K18912	ko00340,map00340	-	R11013	RC03323,RC03324	ko00000,ko00001,ko01000	-	-	-	FGE-sulfatase,Pkinase
REGS1_k127_7012100_0	266117.Rxyl_2407	2.588e-82	285.0	COG1878@1|root,COG1878@2|Bacteria,2GUSA@201174|Actinobacteria,4CSW4@84995|Rubrobacteria	84995|Rubrobacteria	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
REGS1_k127_7012100_1	1129794.C427_0873	6.898e-80	276.0	COG2515@1|root,COG2515@2|Bacteria,1MVYF@1224|Proteobacteria,1RMYP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Catalyzes the alpha,beta-elimination reaction of D- cysteine and of several D-cysteine derivatives. It could be a defense mechanism against D-cysteine	-	-	4.4.1.15,4.4.1.25	ko:K05396,ko:K17950	ko00270,map00270	-	R01874,R07634	RC00382,RC01784	ko00000,ko00001,ko01000	-	-	-	PALP
REGS1_k127_7019699_1	290397.Adeh_0480	5.269e-12	70.0	COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,42S59@68525|delta/epsilon subdivisions,2WNGW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	hybA	-	-	-	-	-	-	-	-	-	-	-	Fer4_11,Fer4_4,TAT_signal
REGS1_k127_7019699_0	926569.ANT_16290	1.008e-75	259.0	COG2759@1|root,COG2759@2|Bacteria,2G5QS@200795|Chloroflexi	200795|Chloroflexi	F	Belongs to the formate--tetrahydrofolate ligase family	fhs	GO:0003674,GO:0003824,GO:0004329,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006144,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009112,GO:0009113,GO:0009256,GO:0009257,GO:0009396,GO:0009987,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0016874,GO:0016879,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042440,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046112,GO:0046148,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	1.5.1.5,3.5.4.9,6.3.4.3	ko:K00288,ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00141,M00377	R00943,R01220,R01655	RC00026,RC00111,RC00202,RC00578	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	FTHFS
REGS1_k127_705354_3	1347086.CCBA010000001_gene1977	3.675e-17	85.0	COG0718@1|root,COG0718@2|Bacteria,1VA1S@1239|Firmicutes,4HKH3@91061|Bacilli,1ZGZI@1386|Bacillus	91061|Bacilli	S	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection	yaaK	-	-	ko:K09747	-	-	-	-	ko00000	-	-	-	YbaB_DNA_bd
REGS1_k127_705354_0	926569.ANT_01340	1.545e-118	401.0	COG2812@1|root,COG2812@2|Bacteria,2G5PK@200795|Chloroflexi	200795|Chloroflexi	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
REGS1_k127_705354_1	1330700.JQNC01000003_gene971	1.124e-31	132.0	2E64T@1|root,330TJ@2|Bacteria,1WK59@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_705354_2	1286171.EAL2_c08220	2.769e-18	98.0	COG4758@1|root,COG4758@2|Bacteria,1UITP@1239|Firmicutes,24NAQ@186801|Clostridia	186801|Clostridia	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF2154,Toast_rack_N
REGS1_k127_706075_5	926569.ANT_23120	3.211e-45	175.0	COG3764@1|root,COG3764@2|Bacteria,2G98S@200795|Chloroflexi	200795|Chloroflexi	M	PFAM peptidase C60, sortase A and B	-	-	3.4.22.70	ko:K07284	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Sortase
REGS1_k127_706075_9	768706.Desor_2402	4.934e-05	48.0	COG0526@1|root,COG4232@1|root,COG0526@2|Bacteria,COG4232@2|Bacteria,1V9UQ@1239|Firmicutes,24DK4@186801|Clostridia,262P8@186807|Peptococcaceae	186801|Clostridia	CO	cytochrome c biogenesis protein, transmembrane region	-	-	-	ko:K06196	-	-	-	-	ko00000,ko02000	5.A.1.2	-	-	DsbD,Thioredoxin
REGS1_k127_706075_3	926569.ANT_04130	3.602e-75	274.0	COG2203@1|root,COG4585@1|root,COG2203@2|Bacteria,COG4585@2|Bacteria,2G8F9@200795|Chloroflexi	200795|Chloroflexi	T	histidine kinase, dimerisation and phosphoacceptor region	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GAF_3,HATPase_c,HisKA_3
REGS1_k127_706075_6	926554.KI912675_gene2099	8.333e-41	169.0	COG4409@1|root,COG4409@2|Bacteria,1WN1X@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	exo-alpha-(2->6)-sialidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_706075_4	500153.JOEK01000009_gene4819	5.03e-73	254.0	COG0566@1|root,COG0566@2|Bacteria,2GP9S@201174|Actinobacteria	201174|Actinobacteria	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	-	-	-	-	-	-	-	-	-	-	-	-	SpoU_methylase,SpoU_sub_bind
REGS1_k127_706075_1	1540257.JQMW01000012_gene2642	1.728e-98	327.0	COG2820@1|root,COG2820@2|Bacteria,1TQ71@1239|Firmicutes,2482S@186801|Clostridia,36GH9@31979|Clostridiaceae	186801|Clostridia	F	Phosphorylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PNP_UDP_1
REGS1_k127_706075_2	926550.CLDAP_35490	1.373e-97	334.0	COG2730@1|root,COG3103@1|root,COG2730@2|Bacteria,COG4991@2|Bacteria,2G7Y2@200795|Chloroflexi	200795|Chloroflexi	G	Belongs to the glycosyl hydrolase 5 (cellulase A) family	-	-	-	-	-	-	-	-	-	-	-	-	Cellulase
REGS1_k127_706075_0	1183438.GKIL_3646	1.759e-125	420.0	COG1215@1|root,COG1215@2|Bacteria,1G1FP@1117|Cyanobacteria	1117|Cyanobacteria	M	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3
REGS1_k127_706075_7	1410618.JNKI01000025_gene2069	5.52e-12	78.0	COG3307@1|root,COG3307@2|Bacteria,1TQGY@1239|Firmicutes,4H249@909932|Negativicutes	909932|Negativicutes	M	O-antigen polymerase	-	-	-	ko:K18814	-	-	-	-	ko00000,ko02000	9.B.67.1	-	-	Wzy_C
REGS1_k127_706075_8	1107311.Q767_06870	2.118e-11	76.0	28X89@1|root,2ZJ6D@2|Bacteria,4NM59@976|Bacteroidetes,1I885@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
REGS1_k127_7063420_0	926569.ANT_03530	7.434e-264	839.0	COG0188@1|root,COG0188@2|Bacteria,2G5Q2@200795|Chloroflexi	200795|Chloroflexi	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
REGS1_k127_7063420_1	926550.CLDAP_40000	6.663e-90	301.0	COG0035@1|root,COG0035@2|Bacteria,2G6CS@200795|Chloroflexi	200795|Chloroflexi	F	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate	upp	-	2.4.2.9	ko:K00761	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000	-	-	-	UPRTase
REGS1_k127_7063420_2	926550.CLDAP_02830	1.785e-55	200.0	COG2131@1|root,COG2131@2|Bacteria,2G7AC@200795|Chloroflexi	200795|Chloroflexi	F	MafB19-like deaminase	-	-	3.5.4.12	ko:K01493	ko00240,ko01100,map00240,map01100	M00429	R01663	RC00074	ko00000,ko00001,ko00002,ko01000,ko02044	-	-	-	dCMP_cyt_deam_1
REGS1_k127_7063420_3	926550.CLDAP_05580	1.979e-23	105.0	COG1608@1|root,COG1608@2|Bacteria,2G6TH@200795|Chloroflexi	200795|Chloroflexi	S	PFAM aspartate glutamate uridylate kinase	-	-	2.7.4.26	ko:K06981	ko00900,ko01110,ko01130,map00900,map01110,map01130	-	R10093	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
REGS1_k127_7069805_0	926569.ANT_22870	3.641e-100	332.0	COG0213@1|root,COG0213@2|Bacteria,2G64G@200795|Chloroflexi	200795|Chloroflexi	F	PFAM glycosyl transferase family 3	pdp	-	2.4.2.2	ko:K00756	ko00240,ko01100,map00240,map01100	-	R01570,R01876,R02296,R02484	RC00063	ko00000,ko00001,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3,PYNP_C
REGS1_k127_7086838_21	546269.HMPREF0389_00842	5.756e-28	117.0	COG0091@1|root,COG0091@2|Bacteria,1V6PU@1239|Firmicutes,24JF4@186801|Clostridia,25RIS@186804|Peptostreptococcaceae	186801|Clostridia	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rplV	-	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
REGS1_k127_7086838_5	926569.ANT_10100	2.534e-71	247.0	COG0092@1|root,COG0092@2|Bacteria,2G691@200795|Chloroflexi	200795|Chloroflexi	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
REGS1_k127_7086838_7	1347392.CCEZ01000013_gene2683	9.21e-61	212.0	COG0197@1|root,COG0197@2|Bacteria,1V1AY@1239|Firmicutes,24FQX@186801|Clostridia,36E4K@31979|Clostridiaceae	186801|Clostridia	J	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs	rplP	-	-	ko:K02878	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
REGS1_k127_7086838_25	867903.ThesuDRAFT_00567	7.102e-12	69.0	COG0255@1|root,COG0255@2|Bacteria,1VEME@1239|Firmicutes,24QV1@186801|Clostridia,3WCNW@538999|Clostridiales incertae sedis	186801|Clostridia	J	Belongs to the universal ribosomal protein uL29 family	rpmC	-	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
REGS1_k127_7086838_22	1120973.AQXL01000112_gene1082	5.221e-22	102.0	COG0186@1|root,COG0186@2|Bacteria,1V9YC@1239|Firmicutes,4HKDN@91061|Bacilli,27A5X@186823|Alicyclobacillaceae	91061|Bacilli	J	Ribosomal protein S17	rpsQ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
REGS1_k127_7086838_10	110319.CF8_0686	2.083e-54	192.0	COG0093@1|root,COG0093@2|Bacteria,2IHNX@201174|Actinobacteria,4DQTB@85009|Propionibacteriales	201174|Actinobacteria	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rplN	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0008150,GO:0015934,GO:0016020,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0071944,GO:0097159,GO:1901363,GO:1990904	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
REGS1_k127_7086838_19	391009.Tmel_0964	4.056e-36	139.0	COG0198@1|root,COG0198@2|Bacteria,2GD31@200918|Thermotogae	200918|Thermotogae	J	One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplX	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,ribosomal_L24
REGS1_k127_7086838_3	1121422.AUMW01000023_gene2774	1.39e-77	267.0	COG0094@1|root,COG0094@2|Bacteria,1TPE0@1239|Firmicutes,247X0@186801|Clostridia,2603I@186807|Peptococcaceae	186801|Clostridia	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rplE	-	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
REGS1_k127_7086838_23	926569.ANT_10170	1.223e-20	93.0	COG0199@1|root,COG0199@2|Bacteria,2G74J@200795|Chloroflexi	200795|Chloroflexi	J	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site	rpsN	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
REGS1_k127_7086838_15	795359.TOPB45_0767	5.368e-44	164.0	COG0096@1|root,COG0096@2|Bacteria,2GHUB@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rpsH	-	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
REGS1_k127_7086838_8	926569.ANT_10190	1.239e-60	215.0	COG0097@1|root,COG0097@2|Bacteria,2G6HZ@200795|Chloroflexi	200795|Chloroflexi	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rplF	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
REGS1_k127_7086838_16	525904.Tter_0731	8.047e-42	156.0	COG0256@1|root,COG0256@2|Bacteria,2NPVI@2323|unclassified Bacteria	2|Bacteria	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rplR	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18p
REGS1_k127_7086838_9	926550.CLDAP_03930	3.306e-56	201.0	COG0098@1|root,COG0098@2|Bacteria,2G6M9@200795|Chloroflexi	200795|Chloroflexi	J	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body	rpsE	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
REGS1_k127_7086838_24	479434.Sthe_1054	3.181e-12	70.0	COG1841@1|root,COG1841@2|Bacteria,2G7E7@200795|Chloroflexi,27YRK@189775|Thermomicrobia	189775|Thermomicrobia	J	Ribosomal protein L30p/L7e	rpmD	-	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
REGS1_k127_7086838_17	471852.Tcur_4302	6.141e-41	156.0	COG0200@1|root,COG0200@2|Bacteria,2II6M@201174|Actinobacteria,4EIUJ@85012|Streptosporangiales	201174|Actinobacteria	J	Binds to the 23S rRNA	rplO	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015934,GO:0016020,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
REGS1_k127_7086838_0	479434.Sthe_1056	1.254e-149	485.0	COG0201@1|root,COG0201@2|Bacteria,2G5X4@200795|Chloroflexi,27XI1@189775|Thermomicrobia	189775|Thermomicrobia	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
REGS1_k127_7086838_6	926569.ANT_10250	2.645e-61	218.0	COG0563@1|root,COG0563@2|Bacteria,2G6GP@200795|Chloroflexi	200795|Chloroflexi	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK,ADK_lid
REGS1_k127_7086838_4	926550.CLDAP_03880	2.52e-74	258.0	COG0024@1|root,COG0024@2|Bacteria,2G6AV@200795|Chloroflexi	200795|Chloroflexi	J	TIGRFAM methionine aminopeptidase, type I	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
REGS1_k127_7086838_26	411474.COPEUT_02181	2.229e-11	72.0	COG0257@1|root,COG0257@2|Bacteria,1VK4F@1239|Firmicutes,24UGF@186801|Clostridia	186801|Clostridia	J	Belongs to the bacterial ribosomal protein bL36 family	rpmJ	-	-	ko:K02919	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L36
REGS1_k127_7086838_14	1089553.Tph_c25600	6.187e-45	166.0	COG0099@1|root,COG0099@2|Bacteria,1V3JH@1239|Firmicutes,24HCT@186801|Clostridia,42G97@68295|Thermoanaerobacterales	186801|Clostridia	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	-	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
REGS1_k127_7086838_13	316274.Haur_4938	1.405e-47	174.0	COG0100@1|root,COG0100@2|Bacteria,2G6HG@200795|Chloroflexi,375IQ@32061|Chloroflexia	32061|Chloroflexia	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome	rpsK	-	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
REGS1_k127_7086838_2	309801.trd_0958	2.199e-79	270.0	COG0522@1|root,COG0522@2|Bacteria,2G6AZ@200795|Chloroflexi,27XMY@189775|Thermomicrobia	189775|Thermomicrobia	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	-	-	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
REGS1_k127_7086838_1	926550.CLDAP_03830	5.129e-116	383.0	COG0202@1|root,COG0202@2|Bacteria,2G5M9@200795|Chloroflexi	200795|Chloroflexi	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	GO:0003674,GO:0003824,GO:0003899,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
REGS1_k127_7086838_20	1123288.SOV_2c10250	1.573e-35	138.0	COG0203@1|root,COG0203@2|Bacteria,1V6JQ@1239|Firmicutes,4H4TR@909932|Negativicutes	909932|Negativicutes	J	Ribosomal protein L17	rplQ	-	-	ko:K02879	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L17
REGS1_k127_7086838_11	555079.Toce_0152	3.541e-53	196.0	COG0101@1|root,COG0101@2|Bacteria,1TQUY@1239|Firmicutes,248W2@186801|Clostridia,42FMH@68295|Thermoanaerobacterales	186801|Clostridia	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	-	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
REGS1_k127_7086838_12	626523.GCWU000342_02318	2.027e-49	179.0	COG0102@1|root,COG0102@2|Bacteria,1V3HX@1239|Firmicutes,24HD9@186801|Clostridia	186801|Clostridia	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	-	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
REGS1_k127_7086838_18	1382356.JQMP01000003_gene2292	5.935e-37	145.0	COG0103@1|root,COG0103@2|Bacteria,2G6UZ@200795|Chloroflexi,27YEC@189775|Thermomicrobia	189775|Thermomicrobia	J	Belongs to the universal ribosomal protein uS9 family	rpsI	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
REGS1_k127_7101552_4	56107.Cylst_0479	1.143e-23	109.0	COG2931@1|root,COG2931@2|Bacteria,1GIZT@1117|Cyanobacteria,1HMI7@1161|Nostocales	1117|Cyanobacteria	Q	Haemolysin-type calcium-binding repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind,VCBS
REGS1_k127_7101552_1	525904.Tter_2199	1.565e-88	302.0	COG2227@1|root,COG2227@2|Bacteria,2NRF7@2323|unclassified Bacteria	2|Bacteria	H	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_12,Methyltransf_25
REGS1_k127_7101552_0	926550.CLDAP_39900	8.474e-187	607.0	COG3534@1|root,COG3534@2|Bacteria,2G82R@200795|Chloroflexi	200795|Chloroflexi	G	alpha-L-arabinofuranosidase	-	-	-	-	-	-	-	-	-	-	-	-	CBM_2
REGS1_k127_7101552_2	999541.bgla_2g02020	2.766e-49	180.0	COG5478@1|root,COG5478@2|Bacteria,1MZMZ@1224|Proteobacteria,2VT3H@28216|Betaproteobacteria,1K1XS@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Low affinity iron permease	-	-	-	-	-	-	-	-	-	-	-	-	Iron_permease
REGS1_k127_7101552_3	32057.KB217478_gene5170	6.432e-35	144.0	COG1524@1|root,COG1524@2|Bacteria	2|Bacteria	S	mannose-ethanolamine phosphotransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
REGS1_k127_7178758_2	926569.ANT_07260	5.339e-102	339.0	COG4820@1|root,COG4820@2|Bacteria	2|Bacteria	E	ethanolamine catabolic process	eutJ	-	-	ko:K04024	-	-	-	-	ko00000	-	-	-	FtsA,HSP70,MreB_Mbl,PilM_2
REGS1_k127_7178758_3	926569.ANT_07270	2.52e-99	327.0	COG4577@1|root,COG4577@2|Bacteria	2|Bacteria	CQ	ethanolamine catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	BMC
REGS1_k127_7178758_9	1184609.KILIM_086_00140	2.423e-06	54.0	2DCDY@1|root,2ZDSU@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_7178758_5	926550.CLDAP_11890	1.308e-58	213.0	COG1262@1|root,COG1262@2|Bacteria	2|Bacteria	T	PFAM Formylglycine-generating sulfatase enzyme	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	FGE-sulfatase,Pkinase
REGS1_k127_7178758_8	246194.CHY_0688	2.874e-11	68.0	COG4576@1|root,COG4576@2|Bacteria,1VEI4@1239|Firmicutes,24QJA@186801|Clostridia,42HKJ@68295|Thermoanaerobacterales	186801|Clostridia	CQ	Ethanolamine utilisation protein EutN/carboxysome	ccmL	-	-	ko:K04028	-	-	-	-	ko00000	-	-	-	EutN_CcmL
REGS1_k127_7178758_7	1499967.BAYZ01000013_gene6423	7.872e-19	89.0	COG4576@1|root,COG4576@2|Bacteria,2NS06@2323|unclassified Bacteria	2|Bacteria	CQ	Ethanolamine utilisation protein EutN/carboxysome	eutN	GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0050896,GO:0051716	-	ko:K04028	-	-	-	-	ko00000	-	-	-	EutN_CcmL
REGS1_k127_7178758_1	926569.ANT_05370	5.88e-123	410.0	COG2723@1|root,COG2723@2|Bacteria,2G5QE@200795|Chloroflexi	200795|Chloroflexi	G	PFAM glycoside hydrolase, family 1	-	-	3.2.1.21	ko:K05350	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_1
REGS1_k127_7178758_6	697281.Mahau_1416	2.951e-54	200.0	COG0235@1|root,COG0235@2|Bacteria,1TS5G@1239|Firmicutes,248NY@186801|Clostridia,42FQD@68295|Thermoanaerobacterales	186801|Clostridia	G	PFAM Class II aldolase adducin	-	-	4.1.2.17	ko:K01628	ko00051,ko01120,map00051,map01120	-	R02262	RC00603,RC00604	ko00000,ko00001,ko01000	-	-	-	Aldolase_II
REGS1_k127_7178758_4	479434.Sthe_1582	2.3e-86	298.0	COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,2G6C0@200795|Chloroflexi,27XKX@189775|Thermomicrobia	189775|Thermomicrobia	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM,Cytochrom_C
REGS1_k127_7178758_0	383372.Rcas_3557	1.056e-234	743.0	COG0843@1|root,COG0843@2|Bacteria,2G5XS@200795|Chloroflexi,3750X@32061|Chloroflexia	32061|Chloroflexia	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
REGS1_k127_7178758_10	1156937.MFUM_700068	8.642e-06	52.0	COG1845@1|root,COG1845@2|Bacteria,46SRD@74201|Verrucomicrobia,37FZZ@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	C	Cytochrome c oxidase subunit III	cyoC	-	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
REGS1_k127_7181968_2	324602.Caur_3521	5.815e-57	203.0	COG4097@1|root,COG4097@2|Bacteria,2G71Y@200795|Chloroflexi,375FI@32061|Chloroflexia	32061|Chloroflexia	P	Ferric reductase like transmembrane component	-	-	-	-	-	-	-	-	-	-	-	-	Ferric_reduct
REGS1_k127_7181968_1	525904.Tter_2128	2.758e-65	235.0	COG1477@1|root,COG1477@2|Bacteria,2NPJE@2323|unclassified Bacteria	2|Bacteria	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	apbE	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
REGS1_k127_7181968_0	926569.ANT_27620	5.036e-87	292.0	COG2210@1|root,COG2210@2|Bacteria,2G77F@200795|Chloroflexi	200795|Chloroflexi	S	DsrE/DsrF/DrsH-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE_2
REGS1_k127_7181968_3	926569.ANT_27630	7.876e-53	187.0	COG2920@1|root,COG2920@2|Bacteria,2G9BI@200795|Chloroflexi	200795|Chloroflexi	P	DsrC like protein	dsrC	-	-	ko:K11179	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DsrC
REGS1_k127_7181968_4	926550.CLDAP_11610	4.509e-40	154.0	COG2427@1|root,COG2427@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1641)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1641
REGS1_k127_7183924_0	589924.Ferp_2318	1.163e-90	302.0	COG1249@1|root,COG1902@1|root,arCOG00615@2157|Archaea,arCOG01068@2157|Archaea,2XT27@28890|Euryarchaeota,246QS@183980|Archaeoglobi	183980|Archaeoglobi	C	NADH oxidase	-	-	1.3.1.34	ko:K00219	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_FMN,Pyr_redox_2
REGS1_k127_7183924_3	323259.Mhun_3222	0.0001126	49.0	COG1598@1|root,arCOG02412@2157|Archaea	2157|Archaea	S	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_7183924_2	118161.KB235922_gene5767	6.166e-11	65.0	COG1724@1|root,COG1724@2|Bacteria,1G9BE@1117|Cyanobacteria,3VKJT@52604|Pleurocapsales	1117|Cyanobacteria	N	HicA toxin of bacterial toxin-antitoxin,	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
REGS1_k127_7183924_1	208444.JNYY01000005_gene6582	1.017e-14	76.0	COG1884@1|root,COG1884@2|Bacteria,2GM65@201174|Actinobacteria,4DZSF@85010|Pseudonocardiales	201174|Actinobacteria	I	Methylmalonyl-CoA mutase	mcmA2a	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
REGS1_k127_7184006_2	485913.Krac_7960	6.443e-30	123.0	COG0500@1|root,COG2226@2|Bacteria,2G78Q@200795|Chloroflexi	200795|Chloroflexi	Q	PFAM Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
REGS1_k127_7184006_0	926569.ANT_24880	3.904e-72	252.0	COG1028@1|root,COG1028@2|Bacteria,2G8EM@200795|Chloroflexi	200795|Chloroflexi	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
REGS1_k127_7184006_1	323848.Nmul_A2110	6.312e-62	214.0	COG0229@1|root,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,2VSHQ@28216|Betaproteobacteria,373GQ@32003|Nitrosomonadales	28216|Betaproteobacteria	C	SelR domain	msrB	-	1.8.4.11,1.8.4.12	ko:K07305,ko:K12267	-	-	-	-	ko00000,ko01000	-	-	-	SelR
REGS1_k127_7215977_0	1128421.JAGA01000002_gene1035	2.496e-106	353.0	COG0303@1|root,COG0303@2|Bacteria,2NP4N@2323|unclassified Bacteria	2|Bacteria	H	MoeA N-terminal region (domain I and II)	moeA	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
REGS1_k127_7215977_1	1382356.JQMP01000001_gene1204	7.825e-18	92.0	COG3764@1|root,COG3764@2|Bacteria,2G70I@200795|Chloroflexi,27Y5J@189775|Thermomicrobia	189775|Thermomicrobia	M	peptidase C60 sortase A and B	-	-	3.4.22.70	ko:K07284	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Sortase
REGS1_k127_7222611_1	926550.CLDAP_04430	7.162e-77	269.0	COG1349@1|root,COG2865@1|root,COG1349@2|Bacteria,COG2865@2|Bacteria,2G7JP@200795|Chloroflexi	200795|Chloroflexi	K	PFAM AAA-4 family protein	-	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AlbA_2,HATPase_c_4,HTH_DeoR
REGS1_k127_7222611_2	326427.Cagg_3626	1.156e-08	60.0	COG2013@1|root,COG2013@2|Bacteria,2G7F5@200795|Chloroflexi,3753I@32061|Chloroflexia	32061|Chloroflexia	S	Mitochondrial biogenesis AIM24	-	-	-	-	-	-	-	-	-	-	-	-	AIM24,zinc_ribbon_2
REGS1_k127_7222611_0	383372.Rcas_3439	1.746e-286	900.0	COG0466@1|root,COG0466@2|Bacteria,2G5TZ@200795|Chloroflexi,374Z8@32061|Chloroflexia	32061|Chloroflexia	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
REGS1_k127_7222611_3	324602.Caur_0436	4.624e-08	58.0	COG0285@1|root,COG0285@2|Bacteria,2G64M@200795|Chloroflexi,37568@32061|Chloroflexia	32061|Chloroflexia	H	PFAM cytoplasmic peptidoglycan synthetase domain protein	-	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M
REGS1_k127_7248681_2	479434.Sthe_2017	8.434e-60	216.0	COG1968@1|root,COG1968@2|Bacteria,2G6F7@200795|Chloroflexi,27Y0J@189775|Thermomicrobia	189775|Thermomicrobia	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
REGS1_k127_7248681_3	1121472.AQWN01000011_gene1256	1.001e-32	140.0	COG0226@1|root,COG0226@2|Bacteria,1TQ5X@1239|Firmicutes,248QU@186801|Clostridia,2601N@186807|Peptococcaceae	186801|Clostridia	P	TIGRFAM phosphate binding protein	pstS	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
REGS1_k127_7248681_0	518766.Rmar_0323	6.242e-170	545.0	COG2256@1|root,COG2256@2|Bacteria,4NEV8@976|Bacteroidetes,1FIYS@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	L	MgsA AAA+ ATPase C terminal	rarA	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
REGS1_k127_7248681_6	1088721.NSU_1229	0.0001514	48.0	COG2329@1|root,COG2329@2|Bacteria,1MZKW@1224|Proteobacteria,2UC1E@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Antibiotic biosynthesis monooxygenase	MA20_03580	-	-	-	-	-	-	-	-	-	-	-	ABM
REGS1_k127_7248681_5	1382306.JNIM01000001_gene1819	1.197e-26	120.0	COG3509@1|root,COG3509@2|Bacteria,2G91Y@200795|Chloroflexi	200795|Chloroflexi	Q	Esterase PHB depolymerase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase_phd
REGS1_k127_7248681_4	1449976.KALB_5978	1.052e-27	115.0	COG3509@1|root,COG3509@2|Bacteria,2GNV6@201174|Actinobacteria,4E37Q@85010|Pseudonocardiales	201174|Actinobacteria	Q	Poly(3-hydroxybutyrate) depolymerase	-	-	-	ko:K03932	-	-	-	-	ko00000	-	CE1	-	Esterase_phd
REGS1_k127_7248681_1	604331.AUHY01000015_gene2651	1.057e-70	255.0	COG0457@1|root,COG0457@2|Bacteria,1WKXF@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Peptidase_C39 like family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C39_2,TPR_2,TPR_8
REGS1_k127_725723_2	1051646.VITU9109_14101	1.087e-61	221.0	COG2515@1|root,COG2515@2|Bacteria,1MVYF@1224|Proteobacteria,1RMYP@1236|Gammaproteobacteria,1XSFN@135623|Vibrionales	135623|Vibrionales	E	Pyridoxal-phosphate dependent enzyme	-	-	4.4.1.25	ko:K17950	ko00270,map00270	-	R07634	RC01784	ko00000,ko00001,ko01000	-	-	-	PALP
REGS1_k127_725723_4	926569.ANT_16590	6.534e-33	132.0	29ATW@1|root,2ZXTA@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_725723_1	706587.Desti_4719	2.798e-139	450.0	COG0003@1|root,COG0003@2|Bacteria,1MUTX@1224|Proteobacteria,42V9Y@68525|delta/epsilon subdivisions,2WND5@28221|Deltaproteobacteria,2MS8W@213462|Syntrophobacterales	28221|Deltaproteobacteria	D	Anion-transporting ATPase	arsA	-	3.6.3.16	ko:K01551	-	-	-	-	ko00000,ko01000,ko02000	3.A.19.1,3.A.21.1,3.A.4.1	-	-	ArsA_ATPase
REGS1_k127_725723_0	706587.Desti_4720	6.936e-145	466.0	COG0003@1|root,COG0003@2|Bacteria,1MUTX@1224|Proteobacteria,42V9Y@68525|delta/epsilon subdivisions,2WND5@28221|Deltaproteobacteria,2MS8W@213462|Syntrophobacterales	28221|Deltaproteobacteria	D	Anion-transporting ATPase	arsA	-	3.6.3.16	ko:K01551	-	-	-	-	ko00000,ko01000,ko02000	3.A.19.1,3.A.21.1,3.A.4.1	-	-	ArsA_ATPase
REGS1_k127_725723_3	706587.Desti_4721	2.085e-36	139.0	2DZFA@1|root,32V98@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_725723_5	706587.Desti_4721	1.205e-20	95.0	2DZFA@1|root,32V98@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_725723_6	1128421.JAGA01000003_gene3244	3.944e-16	83.0	2EMGM@1|root,33F5A@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_7261656_1	338966.Ppro_0754	7.476e-112	375.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,42MGZ@68525|delta/epsilon subdivisions,2WIY6@28221|Deltaproteobacteria,43T9G@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	helicase superfamily c-terminal domain	rhlE-2	-	3.6.4.13	ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DEAD,Helicase_C
REGS1_k127_7261656_0	765420.OSCT_0459	2.354e-119	393.0	COG0714@1|root,COG0714@2|Bacteria,2G5WI@200795|Chloroflexi,37710@32061|Chloroflexia	32061|Chloroflexia	S	PFAM ATPase associated with various cellular activities, AAA_5	-	-	-	-	-	-	-	-	-	-	-	-	AAA_5
REGS1_k127_7261656_2	309801.trd_1210	1.024e-106	364.0	COG3552@1|root,COG3552@2|Bacteria,2G5IW@200795|Chloroflexi,27XNE@189775|Thermomicrobia	189775|Thermomicrobia	S	VWA domain containing CoxE-like protein	-	-	-	ko:K07161	-	-	-	-	ko00000	-	-	-	VWA_CoxE
REGS1_k127_7261656_6	326427.Cagg_1407	8.681e-70	242.0	COG0177@1|root,COG0177@2|Bacteria,2G6A1@200795|Chloroflexi,375YQ@32061|Chloroflexia	32061|Chloroflexia	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
REGS1_k127_7261656_3	1278307.KB907016_gene3433	9.242e-89	300.0	COG2267@1|root,COG2267@2|Bacteria,1R299@1224|Proteobacteria,1T5JY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
REGS1_k127_7261656_7	1183438.GKIL_2106	3.735e-50	196.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	CBM_2
REGS1_k127_7261656_8	94624.Bpet4904	7.974e-31	124.0	COG1011@1|root,COG1011@2|Bacteria,1MVWN@1224|Proteobacteria,2VP4G@28216|Betaproteobacteria,3T622@506|Alcaligenaceae	28216|Betaproteobacteria	S	Haloacid dehalogenase-like hydrolase	-	-	3.8.1.2	ko:K01560	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05287	RC00697	ko00000,ko00001,ko01000	-	-	-	HAD_2
REGS1_k127_7261656_9	1218084.BBJK01000017_gene1948	1.656e-25	109.0	COG1011@1|root,COG1011@2|Bacteria,1MVWN@1224|Proteobacteria,2VP4G@28216|Betaproteobacteria,1K71U@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Haloacid dehalogenase-like hydrolase	-	-	3.8.1.2	ko:K01560	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05287	RC00697	ko00000,ko00001,ko01000	-	-	-	HAD_2
REGS1_k127_7261656_4	383372.Rcas_1559	3.104e-80	282.0	COG0460@1|root,COG0460@2|Bacteria,2G6PU@200795|Chloroflexi,376TN@32061|Chloroflexia	32061|Chloroflexia	C	PFAM homoserine dehydrogenase	-	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	Homoserine_dh,NAD_binding_3
REGS1_k127_7261656_5	196162.Noca_0658	1.354e-78	272.0	COG0667@1|root,COG0667@2|Bacteria,2ICY2@201174|Actinobacteria,4DPHZ@85009|Propionibacteriales	201174|Actinobacteria	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
REGS1_k127_7261656_11	383372.Rcas_1559	3.47e-08	58.0	COG0460@1|root,COG0460@2|Bacteria,2G6PU@200795|Chloroflexi,376TN@32061|Chloroflexia	32061|Chloroflexia	C	PFAM homoserine dehydrogenase	-	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	Homoserine_dh,NAD_binding_3
REGS1_k127_7261656_10	1265505.ATUG01000002_gene1171	1.51e-08	62.0	COG3629@1|root,COG3903@1|root,COG3629@2|Bacteria,COG3903@2|Bacteria,1MWPD@1224|Proteobacteria,434EE@68525|delta/epsilon subdivisions,2WYRT@28221|Deltaproteobacteria,2MN3I@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	BTAD
REGS1_k127_7266269_1	485913.Krac_8498	2.047e-56	209.0	COG0356@1|root,COG0356@2|Bacteria,2G6NF@200795|Chloroflexi	200795|Chloroflexi	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
REGS1_k127_7266269_2	357808.RoseRS_0517	9.324e-22	97.0	COG0636@1|root,COG0636@2|Bacteria,2G72D@200795|Chloroflexi,375Z2@32061|Chloroflexia	32061|Chloroflexia	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpE	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_C
REGS1_k127_7266269_4	1410618.JNKI01000007_gene763	2.231e-11	71.0	COG0711@1|root,COG0711@2|Bacteria,1VB85@1239|Firmicutes,4H4SB@909932|Negativicutes	909932|Negativicutes	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	atpF	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
REGS1_k127_7266269_3	745014.OMB55_00022650	2.045e-15	86.0	COG0712@1|root,COG0712@2|Bacteria,1MVRH@1224|Proteobacteria,1S8X2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	iSF_1195.SF3815,iSFxv_1172.SFxv_4157,iS_1188.S3953	OSCP
REGS1_k127_7266269_0	316274.Haur_4070	3.595e-211	667.0	COG0056@1|root,COG0056@2|Bacteria,2G5YQ@200795|Chloroflexi,3759S@32061|Chloroflexia	32061|Chloroflexia	F	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
REGS1_k127_7267805_1	926550.CLDAP_31360	4.548e-74	267.0	2DZNW@1|root,32VEY@2|Bacteria,2G8XI@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_7267805_0	243233.MCA0142	3.993e-91	312.0	COG0387@1|root,COG0387@2|Bacteria,1N1MR@1224|Proteobacteria,1S1GI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Sodium/calcium exchanger protein	-	-	-	ko:K07300	-	-	-	-	ko00000,ko02000	2.A.19	-	-	Na_Ca_ex
REGS1_k127_7267805_2	935948.KE386495_gene1820	3.071e-38	151.0	COG1555@1|root,COG1555@2|Bacteria,1VA3W@1239|Firmicutes,24MQF@186801|Clostridia,42GEY@68295|Thermoanaerobacterales	186801|Clostridia	L	TIGRFAM competence protein ComEA helix-hairpin-helix	comEA	-	-	ko:K02237	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	HHH_3,SLBB
REGS1_k127_7274525_2	1382306.JNIM01000001_gene3879	1.515e-10	61.0	COG1004@1|root,COG1004@2|Bacteria,2G62F@200795|Chloroflexi	200795|Chloroflexi	C	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	-	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
REGS1_k127_7274525_0	1499967.BAYZ01000154_gene1505	2.086e-120	398.0	COG1804@1|root,COG1804@2|Bacteria,2NQGI@2323|unclassified Bacteria	2|Bacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
REGS1_k127_7274525_1	648996.Theam_0408	8.162e-27	114.0	2CFGB@1|root,33Y5M@2|Bacteria,2G51A@200783|Aquificae	200783|Aquificae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_7282289_4	1452535.JARD01000028_gene2222	6.514e-06	53.0	COG1470@1|root,COG2373@1|root,COG4932@1|root,COG1470@2|Bacteria,COG2373@2|Bacteria,COG4932@2|Bacteria,2GSMR@201174|Actinobacteria,4FQG2@85023|Microbacteriaceae	201174|Actinobacteria	M	cell adhesion involved in biofilm formation	-	-	-	-	-	-	-	-	-	-	-	-	DUF11
REGS1_k127_7282289_0	1462527.CCDM010000001_gene2670	2.104e-92	323.0	COG0028@1|root,COG0028@2|Bacteria,1TQE8@1239|Firmicutes,4H9VR@91061|Bacilli,23JE7@182709|Oceanobacillus	91061|Bacilli	EH	Thiamine pyrophosphate enzyme, central domain	-	-	-	-	-	-	-	-	-	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
REGS1_k127_7282289_2	498761.HM1_1938	9.367e-69	244.0	COG0083@1|root,COG0083@2|Bacteria,1TRWS@1239|Firmicutes,248NA@186801|Clostridia	186801|Clostridia	F	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate	thrB	-	2.7.1.39	ko:K00872	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS03525	GHMP_kinases_C,GHMP_kinases_N
REGS1_k127_7282289_1	1121904.ARBP01000001_gene5870	6.289e-87	297.0	COG0697@1|root,COG0697@2|Bacteria,4NGJR@976|Bacteroidetes,47N5J@768503|Cytophagia	976|Bacteroidetes	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
REGS1_k127_7282289_3	926554.KI912628_gene2716	2.971e-39	149.0	COG3467@1|root,COG3467@2|Bacteria	2|Bacteria	T	pyridoxamine 5'-phosphate	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Pyridox_ox_2
REGS1_k127_7326580_0	926569.ANT_23610	5.43e-169	540.0	COG0172@1|root,COG0172@2|Bacteria,2G5PD@200795|Chloroflexi	200795|Chloroflexi	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
REGS1_k127_7326580_1	926569.ANT_24820	7.351e-102	346.0	COG2265@1|root,COG2265@2|Bacteria,2G6IV@200795|Chloroflexi	200795|Chloroflexi	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	-	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
REGS1_k127_7326580_3	926550.CLDAP_05930	4.462e-79	270.0	COG3383@1|root,COG3383@2|Bacteria	2|Bacteria	C	formate dehydrogenase (NAD+) activity	-	-	-	-	-	-	-	-	-	-	-	-	Fer2_4,Fer4,Fer4_7,Molybdop_Fe4S4,cNMP_binding
REGS1_k127_7326580_5	383372.Rcas_0038	3.268e-13	83.0	COG0739@1|root,COG0739@2|Bacteria,2GBIG@200795|Chloroflexi,3756G@32061|Chloroflexia	32061|Chloroflexia	M	PFAM peptidase M23B	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
REGS1_k127_7326580_4	1242864.D187_005554	7.373e-79	291.0	COG4257@1|root,COG4257@2|Bacteria,1QR8W@1224|Proteobacteria	1224|Proteobacteria	V	Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid	vgb	-	-	ko:K18235	-	-	-	-	ko00000,ko01000,ko01504	-	-	-	-
REGS1_k127_7326580_2	1236902.ANAS01000001_gene1927	6.67e-84	288.0	COG1894@1|root,COG1894@2|Bacteria,2GMMC@201174|Actinobacteria,4EI2I@85012|Streptosporangiales	201174|Actinobacteria	C	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region	-	-	1.17.1.9,1.6.5.3	ko:K00122,ko:K00335	ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200	M00144	R00519,R11945	RC00061,RC02796	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB
REGS1_k127_7326580_6	373903.Hore_01800	4.095e-08	60.0	COG1894@1|root,COG1894@2|Bacteria,1TQB0@1239|Firmicutes,2483E@186801|Clostridia,3WB8V@53433|Halanaerobiales	186801|Clostridia	C	Respiratory-chain NADH dehydrogenase 51 Kd subunit	-	-	1.12.1.3,1.6.5.3	ko:K00335,ko:K18331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
REGS1_k127_7340441_3	1379698.RBG1_1C00001G1223	3.48e-61	219.0	COG0665@1|root,COG0665@2|Bacteria,2NP0X@2323|unclassified Bacteria	2|Bacteria	E	FAD dependent oxidoreductase	-	-	1.5.3.1	ko:K00303	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO
REGS1_k127_7340441_1	1111479.AXAR01000001_gene310	3.158e-87	297.0	COG0506@1|root,COG0506@2|Bacteria,1TQV3@1239|Firmicutes,4HAC1@91061|Bacilli,277YT@186823|Alicyclobacillaceae	91061|Bacilli	E	Proline dehydrogenase	fadM	-	-	ko:K00318	ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130	-	R10507	RC00083	ko00000,ko00001,ko01000	-	-	-	Pro_dh
REGS1_k127_7340441_2	926550.CLDAP_33590	3.693e-87	301.0	COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,2G6DU@200795|Chloroflexi	200795|Chloroflexi	S	PFAM molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	CinA,MoCF_biosynth
REGS1_k127_7340441_0	479434.Sthe_0308	7.158e-107	359.0	COG0115@1|root,COG0115@2|Bacteria,2GAM4@200795|Chloroflexi,27XJA@189775|Thermomicrobia	189775|Thermomicrobia	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
REGS1_k127_7340441_4	335543.Sfum_1251	4.758e-53	211.0	COG2885@1|root,COG2885@2|Bacteria	2|Bacteria	M	chlorophyll binding	-	-	-	-	-	-	-	-	-	-	-	-	Phenol_MetA_deg
REGS1_k127_7340441_5	748449.Halha_2229	4.371e-17	81.0	COG1186@1|root,COG1186@2|Bacteria,1TPSB@1239|Firmicutes,247KU@186801|Clostridia,3WACX@53433|Halanaerobiales	186801|Clostridia	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
REGS1_k127_7344293_0	926550.CLDAP_25010	1.279e-273	858.0	COG0365@1|root,COG0365@2|Bacteria,2G830@200795|Chloroflexi	200795|Chloroflexi	I	Acetyl-coenzyme A synthetase N-terminus	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
REGS1_k127_7344293_1	326427.Cagg_2576	3.947e-120	392.0	COG4213@1|root,COG4213@2|Bacteria,2G6C4@200795|Chloroflexi,377C5@32061|Chloroflexia	32061|Chloroflexia	G	Periplasmic binding protein domain	-	-	-	ko:K10546	ko02010,map02010	M00216	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.5	-	-	Peripla_BP_4
REGS1_k127_7356955_5	1111069.TCCBUS3UF1_1910	3.308e-11	77.0	COG2374@1|root,COG2374@2|Bacteria,1WM95@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	U	PFAM Endonuclease Exonuclease phosphatase	-	-	-	ko:K07004	-	-	-	-	ko00000	-	-	-	Exo_endo_phos,LTD
REGS1_k127_7356955_4	1485545.JQLW01000007_gene672	1.735e-11	71.0	2CD0I@1|root,32RWS@2|Bacteria,1N0MC@1224|Proteobacteria	1224|Proteobacteria	S	Domain of unknown function (DUF4399)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4399
REGS1_k127_7356955_3	1128421.JAGA01000002_gene684	2.842e-22	108.0	2E48V@1|root,32Z4P@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_7356955_0	926550.CLDAP_06820	7.553e-194	617.0	COG3854@1|root,COG3854@2|Bacteria,2G5P5@200795|Chloroflexi	200795|Chloroflexi	S	PFAM single-stranded nucleic acid binding R3H domain protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA,AAA_30,R3H
REGS1_k127_7356955_1	357808.RoseRS_3232	1.922e-62	222.0	COG0125@1|root,COG0125@2|Bacteria,2G6G2@200795|Chloroflexi,375HM@32061|Chloroflexia	32061|Chloroflexia	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
REGS1_k127_7356955_2	479434.Sthe_0949	7.239e-30	124.0	COG3870@1|root,COG3870@2|Bacteria,2G736@200795|Chloroflexi,27YHY@189775|Thermomicrobia	189775|Thermomicrobia	S	Cyclic-di-AMP receptor	-	-	-	-	-	-	-	-	-	-	-	-	CdAMP_rec
REGS1_k127_7395354_1	926550.CLDAP_38140	3.692e-139	456.0	COG0770@1|root,COG0770@2|Bacteria,2G5PN@200795|Chloroflexi	200795|Chloroflexi	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
REGS1_k127_7395354_6	926569.ANT_23350	2.138e-104	350.0	COG0472@1|root,COG0472@2|Bacteria,2G5TJ@200795|Chloroflexi	200795|Chloroflexi	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
REGS1_k127_7395354_2	1128421.JAGA01000002_gene1028	3.49e-132	437.0	COG0771@1|root,COG0771@2|Bacteria,2NP27@2323|unclassified Bacteria	2|Bacteria	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase_C,Mur_ligase_M
REGS1_k127_7395354_8	1382306.JNIM01000001_gene36	1.092e-71	259.0	COG0772@1|root,COG0772@2|Bacteria,2G5MQ@200795|Chloroflexi	200795|Chloroflexi	D	Belongs to the SEDS family	ftsW	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
REGS1_k127_7395354_7	926569.ANT_23380	2.284e-74	265.0	COG0707@1|root,COG0707@2|Bacteria,2G6EH@200795|Chloroflexi	200795|Chloroflexi	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
REGS1_k127_7395354_5	926569.ANT_23400	7.307e-111	378.0	COG0773@1|root,COG0773@2|Bacteria,2G5J4@200795|Chloroflexi	200795|Chloroflexi	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
REGS1_k127_7395354_9	926569.ANT_23420	2.435e-71	251.0	COG0812@1|root,COG0812@2|Bacteria,2G6H3@200795|Chloroflexi	200795|Chloroflexi	M	Cell wall formation	murB	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
REGS1_k127_7395354_3	1382306.JNIM01000001_gene3774	4.722e-130	424.0	COG1181@1|root,COG1181@2|Bacteria,2G5RS@200795|Chloroflexi	200795|Chloroflexi	F	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
REGS1_k127_7395354_10	622637.KE124774_gene2038	7.447e-06	57.0	COG1589@1|root,COG1589@2|Bacteria,1MY1Q@1224|Proteobacteria,2TQPU@28211|Alphaproteobacteria,36YEU@31993|Methylocystaceae	28211|Alphaproteobacteria	M	POTRA domain, FtsQ-type	ftsQ	-	-	ko:K03589	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036	-	-	-	FtsQ,POTRA_1
REGS1_k127_7395354_4	383372.Rcas_1088	4.891e-116	387.0	COG0849@1|root,COG0849@2|Bacteria,2G5V5@200795|Chloroflexi,3757J@32061|Chloroflexia	32061|Chloroflexia	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
REGS1_k127_7395354_0	926550.CLDAP_38020	2.123e-139	454.0	COG0206@1|root,COG0206@2|Bacteria,2G5V2@200795|Chloroflexi	200795|Chloroflexi	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	-	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
REGS1_k127_7398813_1	383372.Rcas_4390	8.476e-90	307.0	COG1420@1|root,COG1420@2|Bacteria,2G6AQ@200795|Chloroflexi,374VS@32061|Chloroflexia	32061|Chloroflexia	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	-	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HrcA
REGS1_k127_7398813_2	326427.Cagg_2695	8.577e-35	139.0	COG0576@1|root,COG0576@2|Bacteria,2G77I@200795|Chloroflexi,375MV@32061|Chloroflexia	32061|Chloroflexia	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
REGS1_k127_7398813_0	485913.Krac_8355	1.764e-95	315.0	COG0443@1|root,COG0443@2|Bacteria,2G5U5@200795|Chloroflexi	2|Bacteria	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
REGS1_k127_7407007_4	525904.Tter_2250	1.081e-87	295.0	COG0842@1|root,COG0842@2|Bacteria	2|Bacteria	V	Transport permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
REGS1_k127_7407007_1	525904.Tter_2251	1.408e-117	383.0	COG1131@1|root,COG1131@2|Bacteria,2NP0I@2323|unclassified Bacteria	2|Bacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
REGS1_k127_7407007_9	926550.CLDAP_35520	2.67e-31	128.0	COG1846@1|root,COG1846@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
REGS1_k127_7407007_6	926569.ANT_03950	1.005e-43	162.0	COG0393@1|root,COG0393@2|Bacteria,2G78F@200795|Chloroflexi	200795|Chloroflexi	S	Putative heavy-metal-binding	-	-	-	-	-	-	-	-	-	-	-	-	YbjQ_1
REGS1_k127_7407007_7	1094508.Tsac_2650	1.231e-43	184.0	COG2206@1|root,COG2206@2|Bacteria,1UZN2@1239|Firmicutes,248SE@186801|Clostridia,42F3X@68295|Thermoanaerobacterales	186801|Clostridia	T	PFAM Metal-dependent phosphohydrolase, HD	-	-	-	-	-	-	-	-	-	-	-	-	HD,HD_5
REGS1_k127_7407007_8	517418.Ctha_2189	2.583e-31	143.0	COG2199@1|root,COG3706@2|Bacteria,1FDXG@1090|Chlorobi	1090|Chlorobi	T	PFAM GGDEF domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
REGS1_k127_7407007_2	1128421.JAGA01000003_gene3677	1.86e-107	367.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	aprX	-	-	ko:K17734	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S8
REGS1_k127_7407007_3	1329516.JPST01000048_gene1896	4.264e-92	318.0	COG2025@1|root,COG2025@2|Bacteria,1TPC8@1239|Firmicutes,4HAE2@91061|Bacilli,27BKT@186824|Thermoactinomycetaceae	91061|Bacilli	C	Electron transfer flavoprotein domain	etfA	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006091,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009055,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0019395,GO:0019752,GO:0022900,GO:0030258,GO:0032787,GO:0033539,GO:0034440,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071704,GO:0072329,GO:0097159,GO:1901265,GO:1901363,GO:1901575	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
REGS1_k127_7407007_5	56780.SYN_02636	2.929e-68	242.0	COG2086@1|root,COG2086@2|Bacteria,1MVH6@1224|Proteobacteria,42RCI@68525|delta/epsilon subdivisions,2WMYC@28221|Deltaproteobacteria,2MQGX@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Electron transfer flavoprotein domain	etfB	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
REGS1_k127_7407007_0	869210.Marky_1644	6.078e-134	435.0	COG1960@1|root,COG1960@2|Bacteria,1WICM@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	I	PFAM Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
REGS1_k127_7424695_2	235985.BBPN01000016_gene5864	8.961e-07	56.0	COG1032@1|root,COG1032@2|Bacteria,2I8XZ@201174|Actinobacteria	201174|Actinobacteria	C	Radical SAM	-	-	-	ko:K18564	ko00332,ko01130,map00332,map01130	-	R10738	RC03266	ko00000,ko00001,ko01000	-	-	-	B12-binding,Radical_SAM
REGS1_k127_7424695_1	673860.AciM339_0431	5.951e-23	114.0	COG1032@1|root,arCOG01356@2157|Archaea,2XU04@28890|Euryarchaeota,3F2W8@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	B12 binding domain	-	-	1.21.98.3	ko:K04034	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R06268,R06269,R06270	RC00741,RC01491,RC01492	ko00000,ko00001,ko01000	-	-	-	B12-binding,Radical_SAM
REGS1_k127_7424695_0	1380356.JNIK01000011_gene1883	4.048e-28	124.0	COG1215@1|root,COG1215@2|Bacteria,2GJCE@201174|Actinobacteria,4EUYK@85013|Frankiales	201174|Actinobacteria	M	Glycosyl transferase family group 2	-	-	-	ko:K11936	ko02026,map02026	-	-	-	ko00000,ko00001,ko01000,ko01003,ko02000	4.D.1.1.2,4.D.1.1.3	GT2	-	Glyco_tranf_2_3,Glycos_transf_2
REGS1_k127_7447641_0	357808.RoseRS_3858	3.48e-126	414.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,2G5ZQ@200795|Chloroflexi,376AA@32061|Chloroflexia	32061|Chloroflexia	C	FAD linked oxidase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_8
REGS1_k127_7447641_2	479434.Sthe_1791	1.055e-78	271.0	COG1024@1|root,COG1024@2|Bacteria,2G5JW@200795|Chloroflexi,27YD9@189775|Thermomicrobia	189775|Thermomicrobia	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
REGS1_k127_7447641_1	926550.CLDAP_36300	1.904e-91	320.0	COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,2G5WM@200795|Chloroflexi	200795|Chloroflexi	DM	PFAM lipopolysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_7447641_3	926550.CLDAP_36310	2.186e-53	211.0	COG0823@1|root,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,PA14,PD40,PKD,VPEP
REGS1_k127_7448349_0	926569.ANT_06180	3.287e-58	220.0	COG1316@1|root,COG1316@2|Bacteria,2G6PZ@200795|Chloroflexi	200795|Chloroflexi	K	TIGRFAM cell envelope-related function transcriptional attenuator, LytR CpsA family	-	-	-	-	-	-	-	-	-	-	-	-	LytR_C,LytR_cpsA_psr
REGS1_k127_7449668_1	1128421.JAGA01000002_gene1072	1.452e-92	310.0	COG1801@1|root,COG1801@2|Bacteria,2NPDU@2323|unclassified Bacteria	2|Bacteria	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
REGS1_k127_7449668_0	1128421.JAGA01000001_gene2047	4.972e-119	389.0	COG0010@1|root,COG0010@2|Bacteria	2|Bacteria	E	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines	rocF	GO:0003674,GO:0003824,GO:0004053,GO:0006082,GO:0006520,GO:0006525,GO:0006807,GO:0008150,GO:0008152,GO:0009064,GO:0009987,GO:0016787,GO:0016810,GO:0016813,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0071704,GO:1901564,GO:1901605	3.5.3.1,3.5.3.11	ko:K01476,ko:K01480	ko00220,ko00330,ko01100,ko01110,ko01130,ko01230,ko05146,map00220,map00330,map01100,map01110,map01130,map01230,map05146	M00029,M00133,M00134	R00551,R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
REGS1_k127_7449668_2	1158318.ATXC01000001_gene573	1.337e-76	264.0	COG0217@1|root,COG0217@2|Bacteria,2G3N5@200783|Aquificae	200783|Aquificae	K	transcriptional regulatory protein	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
REGS1_k127_7449668_3	316274.Haur_4753	1.963e-55	198.0	COG0817@1|root,COG0817@2|Bacteria,2G6MA@200795|Chloroflexi,375KP@32061|Chloroflexia	32061|Chloroflexia	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group	ruvC	GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009987,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
REGS1_k127_7449668_4	1173028.ANKO01000065_gene5626	2.039e-35	139.0	COG1670@1|root,COG1670@2|Bacteria,1G5GV@1117|Cyanobacteria,1HAQ0@1150|Oscillatoriales	1117|Cyanobacteria	J	PFAM Acetyltransferase (GNAT) family	-	-	2.3.1.128	ko:K03790	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_3
REGS1_k127_7472143_4	552811.Dehly_1563	1.303e-23	102.0	COG2336@1|root,COG2336@2|Bacteria,2G9F5@200795|Chloroflexi	200795|Chloroflexi	K	PFAM SpoVT AbrB domain protein	-	-	-	ko:K07172	-	-	-	-	ko00000,ko02048	-	-	-	MazE_antitoxin
REGS1_k127_7472143_3	324925.Ppha_0265	2.168e-48	175.0	COG2337@1|root,COG2337@2|Bacteria	2|Bacteria	T	Toxic component of a toxin-antitoxin (TA) module	chpA	-	-	ko:K07171	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
REGS1_k127_7472143_0	383372.Rcas_1224	3.106e-137	447.0	COG4992@1|root,COG4992@2|Bacteria,2G5TW@200795|Chloroflexi,3758Z@32061|Chloroflexia	32061|Chloroflexia	E	TIGRFAM acetylornithine and succinylornithine aminotransferase	argD	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
REGS1_k127_7472143_2	383372.Rcas_3361	6.251e-79	271.0	COG0548@1|root,COG0548@2|Bacteria,2G6ZG@200795|Chloroflexi,375PI@32061|Chloroflexia	32061|Chloroflexia	F	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
REGS1_k127_7472143_1	357808.RoseRS_4052	2.606e-97	325.0	COG0002@1|root,COG0002@2|Bacteria,2G6D0@200795|Chloroflexi,3759I@32061|Chloroflexia	32061|Chloroflexia	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	-	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
REGS1_k127_7510090_2	479434.Sthe_3217	4.028e-67	237.0	COG0265@1|root,COG0265@2|Bacteria,2GBRP@200795|Chloroflexi,27Z1U@189775|Thermomicrobia	189775|Thermomicrobia	O	Domain present in PSD-95, Dlg, and ZO-1/2.	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
REGS1_k127_7510090_3	1283283.ATXA01000023_gene251	2.274e-45	168.0	COG3576@1|root,COG3576@2|Bacteria,2I2W4@201174|Actinobacteria	201174|Actinobacteria	S	pyridoxamine 5-phosphate	-	-	-	ko:K05558	-	-	-	-	ko00000	-	-	-	Putative_PNPOx
REGS1_k127_7510090_4	926569.ANT_04680	3.92e-43	160.0	COG3467@1|root,COG3467@2|Bacteria,2G77X@200795|Chloroflexi	200795|Chloroflexi	S	PFAM pyridoxamine 5'-phosphate oxidase-related	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
REGS1_k127_7510090_5	536227.CcarbDRAFT_5255	4.893e-17	91.0	COG1388@1|root,COG2340@1|root,COG1388@2|Bacteria,COG2340@2|Bacteria,1V6GZ@1239|Firmicutes,24BAQ@186801|Clostridia,36FMJ@31979|Clostridiaceae	186801|Clostridia	M	PFAM Cysteine-rich secretory protein family	safA	-	-	-	-	-	-	-	-	-	-	-	CAP,LysM
REGS1_k127_7510090_0	515635.Dtur_0780	3.976e-194	621.0	COG1793@1|root,COG1793@2|Bacteria	2|Bacteria	L	dna ligase	lig	GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016874,GO:0016886,GO:0022616,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360,GO:1901576	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N
REGS1_k127_7510090_1	1051632.TPY_1321	3.757e-186	592.0	COG0044@1|root,COG0044@2|Bacteria,1TP8C@1239|Firmicutes,249W6@186801|Clostridia	186801|Clostridia	F	PFAM amidohydrolase	hydA	-	3.5.2.2	ko:K01464	ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100	M00046	R02269,R03055,R08227	RC00632,RC00680	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Amidohydro_1
REGS1_k127_7515459_2	633149.Bresu_3207	3.485e-22	100.0	COG2515@1|root,COG2515@2|Bacteria,1MVYF@1224|Proteobacteria,2TRCB@28211|Alphaproteobacteria,2KF4J@204458|Caulobacterales	204458|Caulobacterales	E	TIGRFAM pyridoxal phosphate-dependent enzymes, D-cysteine desulfhydrase family	-	-	4.4.1.25	ko:K17950	ko00270,map00270	-	R07634	RC01784	ko00000,ko00001,ko01000	-	-	-	PALP
REGS1_k127_7515459_1	706587.Desti_4215	3.449e-42	169.0	COG1392@1|root,COG1392@2|Bacteria,1NDTG@1224|Proteobacteria	1224|Proteobacteria	P	phosphate transport regulator (Distant homolog of PhoU)	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
REGS1_k127_7515459_0	335541.Swol_1646	1.418e-78	274.0	COG0306@1|root,COG0306@2|Bacteria,1TQ3D@1239|Firmicutes,247ZC@186801|Clostridia,42KBW@68298|Syntrophomonadaceae	186801|Clostridia	P	Phosphate transporter family	pit	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
REGS1_k127_7517133_6	649639.Bcell_2650	5.1e-11	70.0	COG3576@1|root,COG3576@2|Bacteria,1V3YD@1239|Firmicutes,4HH46@91061|Bacilli,1ZG6P@1386|Bacillus	91061|Bacilli	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
REGS1_k127_7517133_2	1397284.AYMN01000029_gene3464	4.248e-82	278.0	COG0163@1|root,COG0163@2|Bacteria,1RA0P@1224|Proteobacteria,1RPN1@1236|Gammaproteobacteria,401VW@613|Serratia	1236|Gammaproteobacteria	H	Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN	ubiX	GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663	2.5.1.129	ko:K03186	ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220	M00117	R01238,R02952,R03367,R04985,R04986,R11225	RC00391,RC00814,RC03392	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b2311,iAPECO1_1312.APECO1_4253,iB21_1397.B21_02196,iBWG_1329.BWG_2085,iE2348C_1286.E2348C_2451,iEC55989_1330.EC55989_2555,iECBD_1354.ECBD_1348,iECB_1328.ECB_02236,iECDH10B_1368.ECDH10B_2473,iECDH1ME8569_1439.ECDH1ME8569_2249,iECD_1391.ECD_02236,iECED1_1282.ECED1_2775,iECH74115_1262.ECH74115_3451,iECIAI39_1322.ECIAI39_2460,iECNA114_1301.ECNA114_2401,iECO103_1326.ECO103_2775,iECOK1_1307.ECOK1_2544,iECP_1309.ECP_2350,iECS88_1305.ECS88_2458,iECSE_1348.ECSE_2620,iECSF_1327.ECSF_2187,iECSP_1301.ECSP_3186,iECs_1301.ECs3195,iETEC_1333.ETEC_2447,iEcDH1_1363.EcDH1_1345,iEcE24377_1341.EcE24377A_2605,iEcHS_1320.EcHS_A2462,iEcSMS35_1347.EcSMS35_2467,iG2583_1286.G2583_2848,iJO1366.b2311,iJR904.b2311,iLF82_1304.LF82_2354,iNRG857_1313.NRG857_11705,iSDY_1059.SDY_2510,iUMN146_1321.UM146_05255,iUMNK88_1353.UMNK88_2862,iUTI89_1310.UTI89_C2595,iY75_1357.Y75_RS12120,iZ_1308.Z3573	Flavoprotein
REGS1_k127_7517133_4	748247.AZKH_p0139	2.458e-49	181.0	COG1051@1|root,COG1051@2|Bacteria,1QVI6@1224|Proteobacteria,2WGSD@28216|Betaproteobacteria,2KY2Q@206389|Rhodocyclales	206389|Rhodocyclales	F	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
REGS1_k127_7517133_1	761193.Runsl_0440	3.033e-90	303.0	COG1028@1|root,COG1028@2|Bacteria,4NKUJ@976|Bacteroidetes,47JK4@768503|Cytophagia	976|Bacteroidetes	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
REGS1_k127_7517133_3	767817.Desgi_2400	6.319e-50	184.0	COG1418@1|root,COG1418@2|Bacteria	2|Bacteria	S	mRNA catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	HD
REGS1_k127_7517133_0	1089547.KB913013_gene476	1.101e-180	579.0	COG1012@1|root,COG1012@2|Bacteria,4NEB7@976|Bacteroidetes,47JKD@768503|Cytophagia	976|Bacteroidetes	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.16,1.2.1.20,1.2.1.79	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	M00027	R00713,R00714,R02401	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
REGS1_k127_7517133_5	948106.AWZT01000045_gene5613	4.576e-24	103.0	COG2025@1|root,COG2025@2|Bacteria,1MUFI@1224|Proteobacteria,2VJWA@28216|Betaproteobacteria,1K5AT@119060|Burkholderiaceae	28216|Betaproteobacteria	C	electron transfer flavoprotein, alpha subunit	fixB	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
REGS1_k127_7523133_2	316274.Haur_3817	8.617e-65	233.0	COG0697@1|root,COG0697@2|Bacteria,2G70T@200795|Chloroflexi,3762A@32061|Chloroflexia	32061|Chloroflexia	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
REGS1_k127_7523133_3	1255043.TVNIR_2245	1.332e-10	74.0	COG2227@1|root,COG2227@2|Bacteria,1RE7I@1224|Proteobacteria,1S6PD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	PFAM Tellurite resistance protein TehB	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23,Methyltransf_25,TehB
REGS1_k127_7523133_1	324602.Caur_0487	1.229e-76	264.0	COG1136@1|root,COG1136@2|Bacteria,2G8HT@200795|Chloroflexi,375FM@32061|Chloroflexia	32061|Chloroflexia	V	PFAM ABC transporter related	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
REGS1_k127_7523133_0	926550.CLDAP_37400	4.378e-98	331.0	COG0577@1|root,COG0577@2|Bacteria,2G6IW@200795|Chloroflexi	200795|Chloroflexi	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
REGS1_k127_7558550_1	298654.FraEuI1c_3252	8.142e-21	98.0	COG4177@1|root,COG4177@2|Bacteria,2GMGD@201174|Actinobacteria,4EVUC@85013|Frankiales	201174|Actinobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
REGS1_k127_7558550_3	1356854.N007_10465	1.626e-10	70.0	COG0586@1|root,COG0586@2|Bacteria,1VDM5@1239|Firmicutes,4HME5@91061|Bacilli	91061|Bacilli	S	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
REGS1_k127_7558550_4	1229205.BUPH_06437	2.369e-07	57.0	COG1881@1|root,COG1881@2|Bacteria,1N7JI@1224|Proteobacteria,2W2HZ@28216|Betaproteobacteria,1K75V@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
REGS1_k127_7558550_2	391038.Bphy_3576	8.499e-17	87.0	COG1881@1|root,COG1881@2|Bacteria,1N7JI@1224|Proteobacteria,2W2HZ@28216|Betaproteobacteria,1K75V@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
REGS1_k127_7558550_0	1265505.ATUG01000002_gene2368	3.094e-143	467.0	COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,42NKD@68525|delta/epsilon subdivisions,2WIWV@28221|Deltaproteobacteria,2MIVW@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	-	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
REGS1_k127_7594668_1	536227.CcarbDRAFT_5021	1.409e-17	94.0	COG0457@1|root,COG1611@1|root,COG0457@2|Bacteria,COG1611@2|Bacteria,1UYZH@1239|Firmicutes,24BU9@186801|Clostridia,36F2E@31979|Clostridiaceae	186801|Clostridia	S	tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_2,TPR_8
REGS1_k127_7594668_0	357808.RoseRS_2507	4.539e-48	190.0	COG5305@1|root,COG5305@2|Bacteria,2G7AA@200795|Chloroflexi,375E4@32061|Chloroflexia	200795|Chloroflexi	S	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
REGS1_k127_7623488_0	383372.Rcas_4273	1.266e-119	401.0	COG1070@1|root,COG1070@2|Bacteria,2G5KJ@200795|Chloroflexi	200795|Chloroflexi	G	carbohydrate kinase FGGY	-	-	2.7.1.12	ko:K00851	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	-	R01737	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	FGGY_C,FGGY_N
REGS1_k127_7623488_2	1437425.CSEC_0388	0.0004692	52.0	COG3291@1|root,COG3391@1|root,COG3468@1|root,COG3291@2|Bacteria,COG3391@2|Bacteria,COG3468@2|Bacteria,2JH3E@204428|Chlamydiae	204428|Chlamydiae	MU	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	PKD
REGS1_k127_7636256_1	246194.CHY_0138	6.414e-170	542.0	COG0192@1|root,COG0192@2|Bacteria,1TPCV@1239|Firmicutes,248QF@186801|Clostridia,42ESY@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
REGS1_k127_7636256_3	1128421.JAGA01000004_gene2626	9.402e-102	340.0	COG1089@1|root,COG1089@2|Bacteria,2NP6U@2323|unclassified Bacteria	2|Bacteria	M	Polysaccharide biosynthesis protein	-	-	1.1.1.281	ko:K15856	ko00051,ko00520,map00051,map00520	-	R03397,R03399	RC00182	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
REGS1_k127_7636256_2	1128421.JAGA01000003_gene3003	2.121e-152	488.0	COG1089@1|root,COG1089@2|Bacteria,2NNM2@2323|unclassified Bacteria	2|Bacteria	M	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose	gmd	-	4.2.1.47	ko:K01711	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R00888	RC00402	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
REGS1_k127_7636256_0	926569.ANT_14720	1.096e-195	621.0	COG1109@1|root,COG1109@2|Bacteria,2G5Y4@200795|Chloroflexi	200795|Chloroflexi	G	phosphoglucomutase phosphomannomutase alpha beta alpha domain I	-	-	5.4.2.8	ko:K01840	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01818	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
REGS1_k127_7636256_5	1382304.JNIL01000001_gene2044	6.169e-68	241.0	COG0084@1|root,COG0084@2|Bacteria,1TNY1@1239|Firmicutes,4HA74@91061|Bacilli,27859@186823|Alicyclobacillaceae	91061|Bacilli	L	TatD related DNase	tatD	GO:0003674,GO:0003824,GO:0004518,GO:0004536,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
REGS1_k127_7636256_4	926550.CLDAP_39390	2.828e-71	255.0	COG0142@1|root,COG0142@2|Bacteria,2G6IZ@200795|Chloroflexi	200795|Chloroflexi	H	Belongs to the FPP GGPP synthase family	hepT	-	2.5.1.30,2.5.1.90	ko:K00805,ko:K02523	ko00900,ko01110,map00900,map01110	-	R09247,R09248	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
REGS1_k127_7636256_7	926569.ANT_15080	5.834e-25	118.0	COG1572@1|root,COG1572@2|Bacteria,2G9M8@200795|Chloroflexi	2|Bacteria	S	Ig-like domain from next to BRCA1 gene	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,N_BRCA1_IG
REGS1_k127_7636256_8	1173028.ANKO01000041_gene3177	0.0005282	52.0	COG3103@1|root,COG3103@2|Bacteria,1G4VS@1117|Cyanobacteria,1H942@1150|Oscillatoriales	1117|Cyanobacteria	T	PFAM SH3 type 3	-	-	-	-	-	-	-	-	-	-	-	-	SH3_3
REGS1_k127_7636256_6	304371.MCP_0058	3.489e-62	223.0	COG1063@1|root,arCOG01459@2157|Archaea,2XT9P@28890|Euryarchaeota	28890|Euryarchaeota	E	Catalyzes the NAD(P)( )-dependent oxidation of D-glucose to D-gluconate via gluconolactone. Can utilize both NAD( ) and NADP( ) as electron acceptor. Is involved in the degradation of glucose through a modified Entner-Doudoroff pathway	gdh	GO:0000166,GO:0003674,GO:0003824,GO:0004344,GO:0005488,GO:0005515,GO:0005534,GO:0005536,GO:0005975,GO:0005996,GO:0006006,GO:0006007,GO:0006012,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009987,GO:0016043,GO:0016052,GO:0016491,GO:0016614,GO:0016616,GO:0019318,GO:0019320,GO:0019388,GO:0019595,GO:0022607,GO:0030246,GO:0033498,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0043933,GO:0044085,GO:0044238,GO:0044281,GO:0044282,GO:0046365,GO:0046430,GO:0046872,GO:0046914,GO:0046983,GO:0047910,GO:0047936,GO:0048029,GO:0048037,GO:0050661,GO:0050662,GO:0051259,GO:0051262,GO:0051287,GO:0055114,GO:0065003,GO:0070401,GO:0070403,GO:0071704,GO:0071840,GO:0097159,GO:1901265,GO:1901363,GO:1901575	1.1.1.140,1.1.1.359,1.1.1.360	ko:K00068,ko:K18124,ko:K18125	ko00030,ko00051,ko00052,ko01100,ko01110,ko01130,ko01200,map00030,map00051,map00052,map01100,map01110,map01130,map01200	-	R01096,R05607,R07147,R08544	RC00066,RC00085	ko00000,ko00001,ko01000	-	-	-	ADH_N,Glu_dehyd_C
REGS1_k127_7643893_2	456442.Mboo_2451	2.532e-10	74.0	arCOG00567@1|root,arCOG00567@2157|Archaea,2XVU1@28890|Euryarchaeota,2NA3X@224756|Methanomicrobia	224756|Methanomicrobia	M	glycosyl transferase, family 39	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
REGS1_k127_7643893_1	926550.CLDAP_11930	3.159e-19	103.0	COG2132@1|root,COG5617@1|root,COG2132@2|Bacteria,COG5617@2|Bacteria	2|Bacteria	M	Psort location CytoplasmicMembrane, score	-	-	1.7.2.1	ko:K00368	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000	-	-	-	Copper-bind,Cu-oxidase_2,Cu-oxidase_3,PTPS_related
REGS1_k127_7643893_0	1121438.JNJA01000015_gene1301	8.232e-46	175.0	COG0500@1|root,COG2226@2|Bacteria,1RFBE@1224|Proteobacteria,42VEH@68525|delta/epsilon subdivisions,2WVST@28221|Deltaproteobacteria,2MA0A@213115|Desulfovibrionales	28221|Deltaproteobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23
REGS1_k127_7643893_3	926550.CLDAP_21430	6.149e-09	61.0	COG5305@1|root,COG5305@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2142,PMT_2
REGS1_k127_7682216_0	401526.TcarDRAFT_0568	8.669e-31	126.0	COG1496@1|root,COG1496@2|Bacteria,1TS34@1239|Firmicutes,4H26Q@909932|Negativicutes	909932|Negativicutes	S	Belongs to the multicopper oxidase YfiH RL5 family	-	-	-	ko:K05810	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_4
REGS1_k127_7682216_1	526227.Mesil_0058	1.344e-29	124.0	COG0666@1|root,COG0666@2|Bacteria,1WN2R@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	ankyrin repeats	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_7682216_2	502025.Hoch_2462	2.692e-29	121.0	COG0346@1|root,COG0346@2|Bacteria,1RCGK@1224|Proteobacteria,43375@68525|delta/epsilon subdivisions,2WYIM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Glyoxalase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
REGS1_k127_7682216_5	394.NGR_c29550	9.454e-11	68.0	2DH7Z@1|root,2ZYQ9@2|Bacteria,1PQM8@1224|Proteobacteria,2V2ZX@28211|Alphaproteobacteria,4BJXB@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
REGS1_k127_7738561_4	644282.Deba_0057	4.157e-15	88.0	COG0745@1|root,COG4191@1|root,COG0745@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42M6C@68525|delta/epsilon subdivisions,2WM3G@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
REGS1_k127_7738561_2	889378.Spiaf_0446	2.604e-23	114.0	COG2199@1|root,COG3706@2|Bacteria,2JAX4@203691|Spirochaetes	203691|Spirochaetes	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
REGS1_k127_7738561_1	1121324.CLIT_2c00400	4.316e-59	225.0	COG3437@1|root,COG3437@2|Bacteria,1V7YT@1239|Firmicutes,25ET2@186801|Clostridia	186801|Clostridia	T	metal-dependent phosphohydrolase, HD sub domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HD
REGS1_k127_7738561_5	1123508.JH636440_gene2896	6.681e-08	64.0	COG0745@1|root,COG2199@1|root,COG0745@2|Bacteria,COG3706@2|Bacteria,2J3IY@203682|Planctomycetes	203682|Planctomycetes	T	cheY-homologous receiver domain	-	-	-	ko:K02657	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko02022,ko02035,ko02044	-	-	-	Response_reg
REGS1_k127_7738561_0	1128421.JAGA01000004_gene2493	9.339e-91	317.0	COG0308@1|root,COG0308@2|Bacteria,2NPPZ@2323|unclassified Bacteria	2|Bacteria	E	Peptidase family M1 domain	pepN	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1
REGS1_k127_7738561_3	1123239.KB898628_gene3143	2.57e-19	89.0	COG0476@1|root,COG0476@2|Bacteria,1TQ3U@1239|Firmicutes,4HBGP@91061|Bacilli	91061|Bacilli	H	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2	moeB	-	2.7.7.73,2.7.7.80	ko:K03148,ko:K21029	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF
REGS1_k127_7766277_5	335543.Sfum_1698	4.872e-09	65.0	COG1205@1|root,COG1205@2|Bacteria,1QU0I@1224|Proteobacteria,42M4R@68525|delta/epsilon subdivisions,2WK1V@28221|Deltaproteobacteria,2MQS2@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	DEAD DEAH box helicase	yprA	-	-	ko:K06877	-	-	-	-	ko00000	-	-	-	DEAD,DUF1998,Helicase_C,RNase_H_2
REGS1_k127_7766277_2	118166.JH976537_gene4072	4.679e-39	153.0	COG0500@1|root,COG0500@2|Bacteria,1G56P@1117|Cyanobacteria,1HAXF@1150|Oscillatoriales	1117|Cyanobacteria	Q	Thiopurine S-methyltransferase (TPMT)	-	-	2.1.1.67	ko:K00569	ko00983,map00983	-	R08236,R08239,R08246	RC00003,RC00980,RC02277	ko00000,ko00001,ko01000	-	-	-	TPMT
REGS1_k127_7766277_6	383372.Rcas_2634	5.101e-09	67.0	COG2372@1|root,COG2372@2|Bacteria,2GBCJ@200795|Chloroflexi,377PS@32061|Chloroflexia	32061|Chloroflexia	S	PFAM copper resistance protein CopC	-	-	-	ko:K07156	-	-	-	-	ko00000,ko02000	9.B.62.2	-	-	CopC
REGS1_k127_7766277_0	926550.CLDAP_11690	2.697e-212	694.0	COG0517@1|root,COG0617@1|root,COG0618@1|root,COG0517@2|Bacteria,COG0617@2|Bacteria,COG0618@2|Bacteria,2G8YQ@200795|Chloroflexi	200795|Chloroflexi	H	Polynucleotide adenylyltransferase region	-	-	2.7.7.72	ko:K00974	ko03013,map03013	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	CBS,DHH,DHHA1,PolyA_pol,PolyA_pol_RNAbd
REGS1_k127_7766277_3	1333998.M2A_2851	3.55e-27	123.0	COG0745@1|root,COG2199@1|root,COG0745@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,2TQQM@28211|Alphaproteobacteria,4BRP5@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	T	diguanylate cyclase	pleD	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0042802,GO:0044424,GO:0044464	2.7.7.65	ko:K02488	ko02020,ko04112,map02020,map04112	M00511	R08057	-	ko00000,ko00001,ko00002,ko01000,ko02022	-	-	-	GGDEF,Response_reg
REGS1_k127_7766277_4	243231.GSU1643	1.34e-26	121.0	COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,43BSG@68525|delta/epsilon subdivisions,2WN9P@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Response_reg
REGS1_k127_7766277_7	1232410.KI421424_gene1813	5.386e-08	62.0	2A4CF@1|root,30SY3@2|Bacteria,1RFXP@1224|Proteobacteria,42RIM@68525|delta/epsilon subdivisions,2WNS6@28221|Deltaproteobacteria,43UWE@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Yip1 domain	-	-	-	-	-	-	-	-	-	-	-	-	Yip1
REGS1_k127_7766277_1	525904.Tter_1003	1.279e-199	649.0	COG0847@1|root,COG1199@1|root,COG0847@2|Bacteria,COG1199@2|Bacteria,2NNYS@2323|unclassified Bacteria	2|Bacteria	L	DNA polymerase III, epsilon subunit	dinG	GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016020,GO:0016787,GO:0016788,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0044776,GO:0045004,GO:0045005,GO:0046483,GO:0050896,GO:0051716,GO:0061695,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:1901360,GO:1901576,GO:1902494,GO:1990234	2.7.7.7,3.6.4.12	ko:K02342,ko:K03722	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DEAD,Helicase_C_2,RNase_T,ResIII
REGS1_k127_7781907_0	926569.ANT_14470	9.655e-315	978.0	COG1529@1|root,COG2080@1|root,COG1529@2|Bacteria,COG2080@2|Bacteria,2G5NF@200795|Chloroflexi	200795|Chloroflexi	C	COGs COG1529 Aerobic-type carbon monoxide dehydrogenase large subunit CoxL CutL homologs	xdh	-	-	ko:K12528	ko00450,map00450	-	R07229	RC02420	ko00000,ko00001	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2,Fer2_2
REGS1_k127_7782736_6	1031288.AXAA01000037_gene1009	2.097e-19	98.0	COG2197@1|root,COG4963@1|root,COG2197@2|Bacteria,COG4963@2|Bacteria,1UF2S@1239|Firmicutes,248CD@186801|Clostridia,36GXT@31979|Clostridiaceae	186801|Clostridia	D	NUBPL iron-transfer P-loop NTPase	-	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	AAA_31,ParA,Response_reg
REGS1_k127_7782736_2	1128421.JAGA01000003_gene3692	2.88e-100	341.0	COG0793@1|root,COG0793@2|Bacteria,2NNVZ@2323|unclassified Bacteria	2|Bacteria	M	Belongs to the peptidase S41A family	ctpA	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ,PDZ_2,PG_binding_1,Peptidase_S41
REGS1_k127_7782736_7	926569.ANT_09140	5.047e-05	47.0	COG2199@1|root,COG3706@2|Bacteria,2G8QT@200795|Chloroflexi	200795|Chloroflexi	T	PFAM GGDEF domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GGDEF
REGS1_k127_7782736_4	243164.DET0033	1.008e-38	155.0	COG1392@1|root,COG1392@2|Bacteria,2G8VT@200795|Chloroflexi,34D5H@301297|Dehalococcoidia	301297|Dehalococcoidia	P	Protein of unknown function DUF47	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
REGS1_k127_7782736_0	1379698.RBG1_1C00001G0364	1.08e-118	390.0	COG0306@1|root,COG0306@2|Bacteria,2NP4R@2323|unclassified Bacteria	2|Bacteria	P	Phosphate transporter family	pit	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
REGS1_k127_7782736_5	357808.RoseRS_2507	8.854e-30	138.0	COG5305@1|root,COG5305@2|Bacteria,2G7AA@200795|Chloroflexi,375E4@32061|Chloroflexia	200795|Chloroflexi	S	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
REGS1_k127_7782736_3	926569.ANT_30860	2.593e-40	158.0	COG0204@1|root,COG0204@2|Bacteria,2G78P@200795|Chloroflexi	200795|Chloroflexi	I	PFAM phospholipid glycerol acyltransferase	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
REGS1_k127_7782736_1	1034769.KB910518_gene2025	2.651e-107	356.0	COG1131@1|root,COG1131@2|Bacteria,1TPBQ@1239|Firmicutes,4HBXP@91061|Bacilli,26VNN@186822|Paenibacillaceae	91061|Bacilli	V	Bacitracin ABC transporter, ATP-binding protein	bcrA	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
REGS1_k127_7782736_8	543632.JOJL01000017_gene9891	8.782e-05	48.0	COG1277@1|root,COG1277@2|Bacteria,2IING@201174|Actinobacteria,4DGDD@85008|Micromonosporales	201174|Actinobacteria	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_4
REGS1_k127_7803410_2	1235794.C811_00145	1.715e-30	124.0	COG0463@1|root,COG0463@2|Bacteria,2I3C0@201174|Actinobacteria,4CVGT@84998|Coriobacteriia	84998|Coriobacteriia	M	PFAM Glycosyl transferase family 2	-	-	2.4.2.53	ko:K10012	ko00520,ko01503,map00520,map01503	M00721,M00761	R07661	RC00005,RC02954	ko00000,ko00001,ko00002,ko01000,ko01005,ko02000	4.D.2.1.8	GT2	-	Glycos_transf_2
REGS1_k127_7803410_0	1121015.N789_01080	5.016e-74	261.0	COG0451@1|root,COG0451@2|Bacteria,1MU7J@1224|Proteobacteria,1RPTA@1236|Gammaproteobacteria,1X30C@135614|Xanthomonadales	1224|Proteobacteria	M	NAD dependent epimerase dehydratase	-	-	5.1.3.6	ko:K08679	ko00520,ko01100,map00520,map01100	-	R01385	RC00289	ko00000,ko00001,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
REGS1_k127_7803410_1	1128421.JAGA01000002_gene1777	7.439e-51	185.0	COG2301@1|root,COG2301@2|Bacteria	2|Bacteria	G	Belongs to the HpcH HpaI aldolase family	citE	-	3.1.2.30,4.1.3.25,4.1.3.34	ko:K01644,ko:K14451,ko:K18292	ko00630,ko00660,ko01100,ko01120,ko01200,ko02020,map00630,map00660,map01100,map01120,map01200,map02020	M00373	R00237,R00362,R10612	RC00004,RC00014,RC00067,RC00502,RC01118,RC01205	ko00000,ko00001,ko00002,ko01000	-	-	-	HpcH_HpaI,PEP-utilizers_C
REGS1_k127_7882759_0	485913.Krac_10499	2.543e-67	252.0	COG4251@1|root,COG5002@1|root,COG4251@2|Bacteria,COG5002@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
REGS1_k127_7882759_2	56780.SYN_01954	7.505e-54	211.0	COG4585@1|root,COG4585@2|Bacteria,1MWPN@1224|Proteobacteria,42RUN@68525|delta/epsilon subdivisions,2WNJZ@28221|Deltaproteobacteria,2MR4S@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE4,HAMP,HATPase_c,HisKA_3,PAS_3,PAS_4,PAS_9
REGS1_k127_7882759_1	690850.Desaf_2891	3.885e-66	239.0	COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,42R03@68525|delta/epsilon subdivisions,2WMTZ@28221|Deltaproteobacteria,2MCTY@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
REGS1_k127_7885972_1	357808.RoseRS_1630	1.306e-32	129.0	COG0438@1|root,COG0438@2|Bacteria,2G82G@200795|Chloroflexi,375AN@32061|Chloroflexia	32061|Chloroflexia	M	PFAM glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4,Glycos_transf_1
REGS1_k127_7885972_0	1128421.JAGA01000002_gene1172	3.847e-55	207.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	mtfA	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
REGS1_k127_7885972_2	326427.Cagg_2453	3.3e-07	57.0	2EU3R@1|root,33MKI@2|Bacteria,2G9PI@200795|Chloroflexi,375XX@32061|Chloroflexia	32061|Chloroflexia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_789157_0	926550.CLDAP_38200	5.174e-249	793.0	COG0086@1|root,COG0086@2|Bacteria,2G632@200795|Chloroflexi	200795|Chloroflexi	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
REGS1_k127_789157_1	1128421.JAGA01000002_gene1074	1.227e-113	380.0	28HWT@1|root,2Z82P@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Xpo1
REGS1_k127_7912501_0	640081.Dsui_2187	4.058e-216	681.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VJJ2@28216|Betaproteobacteria,2KUZM@206389|Rhodocyclales	206389|Rhodocyclales	I	COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
REGS1_k127_7912501_1	196490.AUEZ01000063_gene1534	2.857e-23	106.0	COG1680@1|root,COG1680@2|Bacteria,1NHIY@1224|Proteobacteria,2U0A3@28211|Alphaproteobacteria,3JXCG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
REGS1_k127_791894_3	1499967.BAYZ01000195_gene3093	5.05e-57	205.0	COG2129@1|root,COG2129@2|Bacteria	2|Bacteria	L	metallophosphoesterase	Z012_09970	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Metallophos_2
REGS1_k127_791894_2	649638.Trad_1708	3.512e-73	258.0	COG1475@1|root,COG1475@2|Bacteria,1WIS1@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	K	Domain of unknown function (DUF4032)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4032,ParBc
REGS1_k127_791894_4	118168.MC7420_6703	6.211e-24	108.0	COG1611@1|root,COG1611@2|Bacteria	2|Bacteria	S	cytokinin biosynthetic process	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
REGS1_k127_791894_0	926569.ANT_10600	4.73e-177	566.0	COG0442@1|root,COG0442@2|Bacteria,2G636@200795|Chloroflexi	200795|Chloroflexi	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro)	proS	GO:0003674,GO:0003824,GO:0004812,GO:0004827,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006433,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017101,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,ProRS-C_1,tRNA-synt_2b
REGS1_k127_791894_1	1123320.KB889640_gene4470	2.328e-85	291.0	COG0702@1|root,COG0702@2|Bacteria	2|Bacteria	GM	epimerase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10,NmrA
REGS1_k127_7935169_1	926569.ANT_16230	9.511e-72	252.0	COG0621@1|root,COG0621@2|Bacteria,2G5UI@200795|Chloroflexi	200795|Chloroflexi	J	modification enzyme, MiaB family	-	-	2.8.4.5	ko:K18707	-	-	R10649	RC00003,RC03221	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,UPF0004
REGS1_k127_7935169_0	1128421.JAGA01000002_gene639	3.082e-267	834.0	COG0481@1|root,COG0481@2|Bacteria,2NNXG@2323|unclassified Bacteria	2|Bacteria	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C
REGS1_k127_7935169_2	247634.GPB2148_1756	2.032e-05	48.0	COG1024@1|root,COG1024@2|Bacteria,1MVQN@1224|Proteobacteria,1RPE2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Enoyl-CoA hydratase	-	-	5.3.3.18	ko:K15866	ko00360,ko01120,map00360,map01120	-	R09837,R09839	RC00004,RC00326,RC02689,RC03003	ko00000,ko00001,ko01000	-	-	-	ECH_1
REGS1_k127_7935822_3	1131266.ARWQ01000010_gene29	1.862e-07	54.0	COG3794@1|root,arCOG02926@2157|Archaea	2157|Archaea	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind
REGS1_k127_7935822_0	656024.FsymDg_4208	1.528e-79	275.0	COG0803@1|root,COG0803@2|Bacteria,2GM1K@201174|Actinobacteria,4ET8X@85013|Frankiales	201174|Actinobacteria	P	Belongs to the bacterial solute-binding protein 9 family	yfeA	-	-	ko:K02077,ko:K09815,ko:K09818	ko02010,map02010	M00242,M00243,M00244	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15,3.A.1.15.3,3.A.1.15.5	-	-	ZnuA
REGS1_k127_7935822_2	479434.Sthe_3155	5.265e-64	228.0	COG1121@1|root,COG1121@2|Bacteria,2G7X2@200795|Chloroflexi,27XH6@189775|Thermomicrobia	200795|Chloroflexi	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K09820,ko:K11710	ko02010,map02010	M00243,M00319	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15	-	-	ABC_tran
REGS1_k127_7935822_1	479434.Sthe_2975	3.532e-78	270.0	COG1108@1|root,COG1108@2|Bacteria,2G6GH@200795|Chloroflexi,27XKB@189775|Thermomicrobia	189775|Thermomicrobia	P	ABC 3 transport family	-	-	-	ko:K09819	-	M00243	-	-	ko00000,ko00002,ko02000	3.A.1.15	-	-	ABC-3
REGS1_k127_7954463_2	926569.ANT_22550	3.825e-91	308.0	COG2313@1|root,COG2313@2|Bacteria,2G5KC@200795|Chloroflexi	200795|Chloroflexi	Q	Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway	psuG	-	4.2.1.70	ko:K16329	ko00240,map00240	-	R01055	RC00432,RC00433	ko00000,ko00001,ko01000	-	-	-	Indigoidine_A
REGS1_k127_7954463_4	867903.ThesuDRAFT_00782	8.424e-68	255.0	COG3639@1|root,COG3639@2|Bacteria,1TQ73@1239|Firmicutes,24AGQ@186801|Clostridia	186801|Clostridia	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02042	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	BPD_transp_1
REGS1_k127_7954463_1	1307761.L21SP2_1483	7.892e-97	323.0	COG3638@1|root,COG3638@2|Bacteria,2J6UW@203691|Spirochaetes	203691|Spirochaetes	P	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system	phnC	-	3.6.3.28	ko:K02041	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.9	-	-	ABC_tran
REGS1_k127_7954463_6	1321778.HMPREF1982_02173	1.939e-30	134.0	COG3221@1|root,COG3221@2|Bacteria,1TR0H@1239|Firmicutes,24A3Q@186801|Clostridia	186801|Clostridia	P	ABC-type phosphate phosphonate transport system periplasmic component	phnD	-	-	ko:K02044	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	Phosphonate-bd
REGS1_k127_7954463_3	525904.Tter_1791	2.148e-71	256.0	COG0392@1|root,COG0392@2|Bacteria,2NQTH@2323|unclassified Bacteria	2|Bacteria	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
REGS1_k127_7954463_5	1121430.JMLG01000021_gene1382	4.246e-62	223.0	COG0169@1|root,COG0169@2|Bacteria,1TQRY@1239|Firmicutes,2497S@186801|Clostridia,2619R@186807|Peptococcaceae	186801|Clostridia	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	-	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_DH,Shikimate_dh_N
REGS1_k127_7954463_0	1382356.JQMP01000004_gene488	2.547e-232	724.0	COG0296@1|root,COG0296@2|Bacteria,2G5IR@200795|Chloroflexi,27XZS@189775|Thermomicrobia	189775|Thermomicrobia	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
REGS1_k127_7969887_1	926569.ANT_12110	1.407e-104	358.0	COG0739@1|root,COG1388@1|root,COG0739@2|Bacteria,COG1388@2|Bacteria	2|Bacteria	M	LysM domain	-	-	2.7.7.6	ko:K03046,ko:K03641,ko:K08642	ko00230,ko00240,ko01100,ko02024,ko03020,map00230,map00240,map01100,map02024,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko01002,ko02000,ko03021,ko03400	2.C.1.2	-	-	Glyco_hydro_18,LysM,OapA,PD40,Peptidase_M23
REGS1_k127_7969887_0	1173023.KE650771_gene131	3.284e-139	462.0	COG1351@1|root,COG1351@2|Bacteria,1GB5D@1117|Cyanobacteria,1JJ9P@1189|Stigonemataceae	1117|Cyanobacteria	F	Thymidylate synthase complementing protein	-	-	-	-	-	-	-	-	-	-	-	-	Thy1
REGS1_k127_7969887_5	1121116.KB894765_gene784	4.132e-09	66.0	COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,2VHR2@28216|Betaproteobacteria,4AA53@80864|Comamonadaceae	28216|Betaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	rpoE	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
REGS1_k127_7969887_3	1123388.AQWU01000060_gene881	3.688e-24	109.0	COG1670@1|root,COG1670@2|Bacteria,1WISV@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	J	PFAM Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
REGS1_k127_7969887_2	477974.Daud_1325	3.096e-40	157.0	COG0494@1|root,COG0494@2|Bacteria,1V6F5@1239|Firmicutes,24JFS@186801|Clostridia,26230@186807|Peptococcaceae	186801|Clostridia	L	pfam nudix	nudF	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
REGS1_k127_7969887_4	1397696.KK211189_gene289	1.324e-18	93.0	COG0726@1|root,COG1388@1|root,COG0726@2|Bacteria,COG1388@2|Bacteria,1V6DN@1239|Firmicutes,4HCJW@91061|Bacilli,3WFKX@539002|Bacillales incertae sedis	91061|Bacilli	GM	Polysaccharide deacetylase	-	-	3.5.1.104	ko:K22278	-	-	-	-	ko00000,ko01000	-	-	-	Cu_amine_oxidN1,LysM,Polysacc_deac_1
REGS1_k127_7974837_7	314230.DSM3645_23746	1.014e-20	93.0	COG0663@1|root,COG0663@2|Bacteria,2IZP3@203682|Planctomycetes	203682|Planctomycetes	S	isoleucine patch	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
REGS1_k127_7974837_2	525904.Tter_0082	1.457e-122	407.0	COG1232@1|root,COG1232@2|Bacteria,2NQRF@2323|unclassified Bacteria	2|Bacteria	H	Flavin containing amine oxidoreductase	-	-	1.3.3.15,1.3.3.4	ko:K00231	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03222,R04178	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
REGS1_k127_7974837_6	357808.RoseRS_0784	1.473e-22	102.0	COG2905@1|root,COG2905@2|Bacteria,2G9RX@200795|Chloroflexi,377Z6@32061|Chloroflexia	32061|Chloroflexia	T	PFAM CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS
REGS1_k127_7974837_3	479434.Sthe_1935	1.298e-111	372.0	COG1071@1|root,COG1071@2|Bacteria,2G5SF@200795|Chloroflexi,27XY9@189775|Thermomicrobia	189775|Thermomicrobia	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	pdhA	-	1.2.4.1	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
REGS1_k127_7974837_1	479434.Sthe_1934	9.506e-133	430.0	COG0022@1|root,COG0022@2|Bacteria,2G60F@200795|Chloroflexi,27Y12@189775|Thermomicrobia	189775|Thermomicrobia	C	Transketolase, pyrimidine binding domain	-	-	1.2.4.1	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
REGS1_k127_7974837_4	479434.Sthe_1933	2.743e-103	350.0	COG0508@1|root,COG0508@2|Bacteria,2G619@200795|Chloroflexi,27Y2C@189775|Thermomicrobia	189775|Thermomicrobia	C	2-oxoacid dehydrogenases acyltransferase (catalytic domain)	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
REGS1_k127_7974837_5	349163.Acry_1232	1.586e-47	187.0	COG0134@1|root,COG0134@2|Bacteria,1MW5K@1224|Proteobacteria,2TSZE@28211|Alphaproteobacteria,2JPUM@204441|Rhodospirillales	204441|Rhodospirillales	E	Belongs to the TrpC family	trpC	-	4.1.1.48	ko:K01609	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508	RC00944	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS
REGS1_k127_7974837_0	671143.DAMO_0892	3.732e-141	455.0	COG4870@1|root,COG4870@2|Bacteria	2|Bacteria	O	transferase activity, transferring glycosyl groups	-	-	3.4.22.38	ko:K01371	ko04142,ko04210,ko04380,ko04620,ko05323,map04142,map04210,map04380,map04620,map05323	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	Peptidase_C1
REGS1_k127_7974837_8	383372.Rcas_0205	0.0002731	53.0	COG5650@1|root,COG5650@2|Bacteria,2GA90@200795|Chloroflexi,377SR@32061|Chloroflexia	32061|Chloroflexia	S	Glycosyltransferase family 87	-	-	-	-	-	-	-	-	-	-	-	-	GT87
REGS1_k127_802922_1	357808.RoseRS_2165	1.889e-78	279.0	COG3552@1|root,COG3552@2|Bacteria,2G5IW@200795|Chloroflexi,3769V@32061|Chloroflexia	32061|Chloroflexia	S	SMART von Willebrand factor, type A	-	-	-	ko:K07161	-	-	-	-	ko00000	-	-	-	VWA_CoxE
REGS1_k127_802922_0	1128421.JAGA01000002_gene1211	2.799e-117	384.0	COG0714@1|root,COG0714@2|Bacteria,2NQNN@2323|unclassified Bacteria	2|Bacteria	S	AAA domain (dynein-related subfamily)	coxD	-	-	-	-	-	-	-	-	-	-	-	AAA_5
REGS1_k127_802922_2	485913.Krac_6952	5.866e-37	146.0	COG1975@1|root,COG3350@1|root,COG1975@2|Bacteria,COG3350@2|Bacteria,2G88Z@200795|Chloroflexi	200795|Chloroflexi	O	YHS domain	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI,YHS
REGS1_k127_803216_0	926550.CLDAP_18560	1.119e-215	679.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
REGS1_k127_803216_1	926550.CLDAP_18660	7.123e-170	541.0	COG0535@1|root,COG0535@2|Bacteria,2G7WG@200795|Chloroflexi	200795|Chloroflexi	C	Iron-sulfur cluster-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM,SPASM
REGS1_k127_803216_3	926569.ANT_08300	2.079e-77	264.0	COG0377@1|root,COG0377@2|Bacteria,2G6GB@200795|Chloroflexi	200795|Chloroflexi	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoB1	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
REGS1_k127_803216_2	324602.Caur_2899	4.671e-119	402.0	COG0649@1|root,COG0649@2|Bacteria,2G5MM@200795|Chloroflexi,3751Y@32061|Chloroflexia	32061|Chloroflexia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD1	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
REGS1_k127_8051413_1	1382306.JNIM01000001_gene1327	4.165e-134	437.0	COG0064@1|root,COG0064@2|Bacteria,2G62Q@200795|Chloroflexi	200795|Chloroflexi	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	-	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
REGS1_k127_8051413_4	1035308.AQYY01000001_gene3310	2.088e-26	115.0	2EMAT@1|root,341AG@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_8051413_5	35754.JNYJ01000014_gene4873	4.7e-05	50.0	COG3468@1|root,COG3637@1|root,COG3468@2|Bacteria,COG3637@2|Bacteria,2IRDI@201174|Actinobacteria,4DF4F@85008|Micromonosporales	201174|Actinobacteria	MU	alpha-L-arabinofuranosidase	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
REGS1_k127_8051413_0	706587.Desti_4134	1.663e-147	482.0	COG3303@1|root,COG3303@2|Bacteria,1P8CP@1224|Proteobacteria,42MXS@68525|delta/epsilon subdivisions,2WKEK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Seven times multi-haem cytochrome CxxCH	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,Multi-haem_cyto
REGS1_k127_8051413_3	756067.MicvaDRAFT_5451	8.523e-105	365.0	COG1361@1|root,COG2931@1|root,COG3210@1|root,COG4932@1|root,COG1361@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG4932@2|Bacteria,1G463@1117|Cyanobacteria,1H97Y@1150|Oscillatoriales	1117|Cyanobacteria	MQ	PFAM Collagen-binding surface protein Cna-like, B-type domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4347,HemolysinCabind,SdrD_B
REGS1_k127_8051413_2	1128421.JAGA01000002_gene1310	6.959e-126	408.0	COG0436@1|root,COG0436@2|Bacteria,2NP1C@2323|unclassified Bacteria	2|Bacteria	E	Aminotransferase	yugH	-	2.6.1.1	ko:K00812,ko:K10907	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
REGS1_k127_8055697_2	1504981.KO116_0091	2.731e-15	81.0	COG3339@1|root,COG3339@2|Bacteria,1MZCY@1224|Proteobacteria,1SANY@1236|Gammaproteobacteria,1XQ4W@135619|Oceanospirillales	135619|Oceanospirillales	S	Protein of unknown function (DUF1232)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1232
REGS1_k127_8055697_0	1382356.JQMP01000003_gene1423	1.898e-45	181.0	COG1316@1|root,COG1316@2|Bacteria,2G6PZ@200795|Chloroflexi,27XRZ@189775|Thermomicrobia	189775|Thermomicrobia	K	cell envelope-related transcriptional attenuator	-	-	-	-	-	-	-	-	-	-	-	-	LytR_C,LytR_cpsA_psr
REGS1_k127_8055697_1	1399115.U719_02590	3.433e-17	86.0	COG0726@1|root,COG1388@1|root,COG0726@2|Bacteria,COG1388@2|Bacteria,1V6DN@1239|Firmicutes,4HCJW@91061|Bacilli,3WFKX@539002|Bacillales incertae sedis	91061|Bacilli	GM	Polysaccharide deacetylase	-	-	3.5.1.104	ko:K22278	-	-	-	-	ko00000,ko01000	-	-	-	Cu_amine_oxidN1,LysM,Polysacc_deac_1
REGS1_k127_8091729_0	1457250.BBMO01000002_gene2310	1.147e-26	125.0	COG0419@1|root,arCOG00368@2157|Archaea	2157|Archaea	L	Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50 Mre11 complex	-	-	-	-	-	-	-	-	-	-	-	-	MMPL,PQQ_2,Peptidase_S74,Pkinase
REGS1_k127_8091729_1	526227.Mesil_3344	3.826e-09	63.0	COG5295@1|root,COG5295@2|Bacteria	2|Bacteria	UW	Hep Hag repeat protein	yeeJ	-	-	ko:K21449	-	-	-	-	ko00000,ko02000	1.B.40.2	-	-	DUF5122,Peptidase_S74,YadA_head,YadA_stalk
REGS1_k127_809614_0	309801.trd_1512	2.345e-145	477.0	COG0525@1|root,COG0525@2|Bacteria,2G5VS@200795|Chloroflexi,27Y20@189775|Thermomicrobia	189775|Thermomicrobia	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
REGS1_k127_809614_1	1382306.JNIM01000001_gene238	2.014e-47	177.0	COG0742@1|root,COG0742@2|Bacteria,2G6Y8@200795|Chloroflexi	200795|Chloroflexi	L	Methyltransferase	-	-	2.1.1.171	ko:K08316	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Cons_hypoth95
REGS1_k127_809614_2	99598.Cal7507_0551	1.645e-39	158.0	COG0500@1|root,COG2226@2|Bacteria,1G0TQ@1117|Cyanobacteria	1117|Cyanobacteria	Q	Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
REGS1_k127_809614_4	1380355.JNIJ01000040_gene5191	9.435e-08	64.0	COG3794@1|root,COG3794@2|Bacteria,1RI9G@1224|Proteobacteria,2U7KA@28211|Alphaproteobacteria,3JYXK@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Copper binding proteins, plastocyanin/azurin family	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cupredoxin_1
REGS1_k127_809614_3	246197.MXAN_7387	8.739e-13	80.0	COG1388@1|root,COG3179@1|root,COG1388@2|Bacteria,COG3179@2|Bacteria,1MYUR@1224|Proteobacteria,42UGP@68525|delta/epsilon subdivisions,2WWB8@28221|Deltaproteobacteria,2YZ5E@29|Myxococcales	28221|Deltaproteobacteria	M	Chitinase class I	-	-	-	ko:K03791	-	-	-	-	ko00000	-	GH19	-	Glyco_hydro_19,LysM,PG_binding_1
REGS1_k127_8098580_1	646529.Desaci_1950	1.66e-43	165.0	COG4870@1|root,COG4870@2|Bacteria,1V236@1239|Firmicutes,24HR0@186801|Clostridia	186801|Clostridia	O	Papain family cysteine protease	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C1
REGS1_k127_8098580_3	44060.JODL01000007_gene1219	5.467e-15	81.0	COG5485@1|root,COG5485@2|Bacteria,2GJYB@201174|Actinobacteria	201174|Actinobacteria	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL
REGS1_k127_8098580_2	1382356.JQMP01000001_gene988	2.654e-28	128.0	COG1413@1|root,COG1413@2|Bacteria,2G6MW@200795|Chloroflexi,27Y7K@189775|Thermomicrobia	189775|Thermomicrobia	C	PBS lyase HEAT-like repeat	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
REGS1_k127_8098580_0	1200792.AKYF01000003_gene287	4.775e-49	184.0	COG1694@1|root,COG3956@2|Bacteria,1TPK1@1239|Firmicutes,4HA0A@91061|Bacilli,26QBT@186822|Paenibacillaceae	91061|Bacilli	S	Protein containing tetrapyrrole methyltransferase domain and MazG-like	yabN	GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009147,GO:0009149,GO:0009151,GO:0009155,GO:0009164,GO:0009166,GO:0009199,GO:0009200,GO:0009203,GO:0009204,GO:0009208,GO:0009210,GO:0009211,GO:0009213,GO:0009215,GO:0009217,GO:0009218,GO:0009219,GO:0009222,GO:0009223,GO:0009259,GO:0009261,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046046,GO:0046047,GO:0046051,GO:0046052,GO:0046060,GO:0046061,GO:0046070,GO:0046075,GO:0046076,GO:0046080,GO:0046081,GO:0046131,GO:0046133,GO:0046135,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658	3.6.1.66	ko:K02428,ko:K02499	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000,ko03036	-	-	-	MazG,TP_methylase
REGS1_k127_8102567_0	311424.DhcVS_1064	9.33e-307	979.0	COG1197@1|root,COG1197@2|Bacteria,2G5UW@200795|Chloroflexi,34CKB@301297|Dehalococcoidia	301297|Dehalococcoidia	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
REGS1_k127_8102567_3	720554.Clocl_0324	6.856e-54	196.0	COG0193@1|root,COG0193@2|Bacteria,1V3NB@1239|Firmicutes,24HMC@186801|Clostridia,3WIEP@541000|Ruminococcaceae	186801|Clostridia	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	-	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
REGS1_k127_8102567_7	926550.CLDAP_37440	1.423e-17	91.0	COG0744@1|root,COG0744@2|Bacteria,2G5ZG@200795|Chloroflexi	200795|Chloroflexi	M	PFAM glycosyl transferase, family 51	-	-	-	-	-	-	-	-	-	-	-	-	Transgly,Transpeptidase
REGS1_k127_8102567_4	639283.Snov_0955	1.24e-47	177.0	COG0293@1|root,COG0293@2|Bacteria,1MW1C@1224|Proteobacteria,2TSBW@28211|Alphaproteobacteria,3EY0A@335928|Xanthobacteraceae	28211|Alphaproteobacteria	J	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit	ftsJ	-	2.1.1.166	ko:K02427	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ
REGS1_k127_8102567_1	765420.OSCT_0202	6.141e-95	319.0	COG1092@1|root,COG1092@2|Bacteria,2G60G@200795|Chloroflexi,376H7@32061|Chloroflexia	32061|Chloroflexia	H	S-adenosylmethionine-dependent methyltransferase	-	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
REGS1_k127_8102567_5	1118054.CAGW01000012_gene4029	4.647e-34	137.0	COG0500@1|root,COG2226@2|Bacteria,1UW6A@1239|Firmicutes,4HHM5@91061|Bacilli,274IR@186822|Paenibacillaceae	91061|Bacilli	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23
REGS1_k127_8102567_10	883066.HMPREF9233_00004	0.0002156	53.0	COG4826@1|root,COG4826@2|Bacteria,2GJ5T@201174|Actinobacteria,4D3CK@85005|Actinomycetales	201174|Actinobacteria	O	This gene contains a nucleotide ambiguity which may be the result of a sequencing error	-	-	-	ko:K13963	ko05146,map05146	-	-	-	ko00000,ko00001	-	-	-	Serpin
REGS1_k127_8102567_8	1173028.ANKO01000250_gene2314	2.311e-09	61.0	COG1506@1|root,COG1506@2|Bacteria,1G200@1117|Cyanobacteria,1H8T3@1150|Oscillatoriales	1117|Cyanobacteria	E	PFAM Prolyl oligopeptidase family	dap2	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
REGS1_k127_8102567_2	41431.PCC8801_0049	3.991e-62	220.0	COG1878@1|root,COG1878@2|Bacteria,1GD8S@1117|Cyanobacteria,3KK69@43988|Cyanothece	1117|Cyanobacteria	S	Putative cyclase	-	-	3.5.1.9	ko:K07130	ko00380,ko00630,ko01100,map00380,map00630,map01100	M00038	R00988,R01959,R04911	RC00263,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Cyclase
REGS1_k127_8102567_6	926550.CLDAP_29380	1.836e-20	102.0	COG1388@1|root,COG1388@2|Bacteria	2|Bacteria	M	LysM domain	rlpA	-	3.5.1.104	ko:K03642,ko:K03791,ko:K22278	-	-	-	-	ko00000,ko01000	-	GH19	-	3D,DPBB_1,Hydrolase_2,LysM
REGS1_k127_8102567_9	1131266.ARWQ01000010_gene29	3.427e-09	67.0	COG3794@1|root,arCOG02926@2157|Archaea	2157|Archaea	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind
REGS1_k127_8106511_2	1330700.JQNC01000003_gene911	2.215e-45	176.0	COG3258@1|root,COG3258@2|Bacteria,1WMNM@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
REGS1_k127_8106511_0	671143.DAMO_0766	6.515e-191	616.0	COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,2NNUW@2323|unclassified Bacteria	2|Bacteria	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	pcmB	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6,1.97.1.9	ko:K03388,ko:K12527	ko00450,ko00680,ko01100,ko01120,ko01200,map00450,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R07229,R11928,R11931,R11943,R11944	RC00011,RC02420	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_20,FlpD,Pyr_redox_2,Pyr_redox_3
REGS1_k127_8106511_1	479434.Sthe_1941	3.005e-56	203.0	COG0745@1|root,COG0745@2|Bacteria,2G8EP@200795|Chloroflexi	200795|Chloroflexi	K	Transcriptional regulatory protein, C terminal	-	-	-	ko:K07667	ko02020,ko02024,map02020,map02024	M00454	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
REGS1_k127_8113383_3	926569.ANT_29030	1.39e-16	83.0	2EAGR@1|root,334K0@2|Bacteria,2G730@200795|Chloroflexi	200795|Chloroflexi	S	PFAM zinc finger, SWIM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	SWIM
REGS1_k127_8113383_0	926550.CLDAP_09110	4.523e-90	309.0	COG2909@1|root,COG2909@2|Bacteria,2G7R6@200795|Chloroflexi	200795|Chloroflexi	K	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16
REGS1_k127_8113383_2	1128421.JAGA01000001_gene2464	3.926e-31	133.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
REGS1_k127_8121363_0	926569.ANT_08650	8.039e-90	302.0	COG1207@1|root,COG1207@2|Bacteria,2G5VC@200795|Chloroflexi	200795|Chloroflexi	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transf_3
REGS1_k127_8121363_1	316274.Haur_4588	4.582e-76	271.0	COG1253@1|root,COG1253@2|Bacteria,2G6D1@200795|Chloroflexi,3752J@32061|Chloroflexia	32061|Chloroflexia	S	PFAM CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
REGS1_k127_8121363_2	1160707.AJIK01000015_gene2171	9.188e-32	129.0	COG0295@1|root,COG0295@2|Bacteria,1V6IP@1239|Firmicutes,4HIJ3@91061|Bacilli,26F5G@186818|Planococcaceae	91061|Bacilli	F	This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis	cdd	-	3.5.4.5	ko:K01489	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01878,R02485,R08221	RC00074,RC00514	ko00000,ko00001,ko01000	-	-	-	dCMP_cyt_deam_1
REGS1_k127_8121363_3	1423748.BALB01000001_gene5	5.829e-11	66.0	COG0050@1|root,COG0050@2|Bacteria,1TPKC@1239|Firmicutes,4HAEH@91061|Bacilli,3F3ZP@33958|Lactobacillaceae	91061|Bacilli	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	GO:0001817,GO:0001819,GO:0002791,GO:0002793,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0009274,GO:0009275,GO:0009986,GO:0010339,GO:0016020,GO:0022610,GO:0030312,GO:0032677,GO:0032757,GO:0032879,GO:0032880,GO:0035821,GO:0044003,GO:0044068,GO:0044403,GO:0044406,GO:0044419,GO:0044424,GO:0044426,GO:0044462,GO:0044464,GO:0044650,GO:0044651,GO:0048518,GO:0048522,GO:0050707,GO:0050708,GO:0050714,GO:0050715,GO:0050789,GO:0050794,GO:0051046,GO:0051047,GO:0051049,GO:0051050,GO:0051222,GO:0051223,GO:0051239,GO:0051240,GO:0051701,GO:0051704,GO:0051817,GO:0065007,GO:0070201,GO:0071944,GO:0090087,GO:1903530,GO:1903532,GO:1904951,GO:2000482,GO:2000484	-	ko:K02358,ko:K15771	ko02010,map02010	M00491	-	-	ko00000,ko00001,ko00002,ko02000,ko03012,ko03029,ko04147	3.A.1.1.16,3.A.1.1.2	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
REGS1_k127_8121363_4	765910.MARPU_14505	9.636e-10	63.0	COG1215@1|root,COG1215@2|Bacteria,1QXFV@1224|Proteobacteria,1T599@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
REGS1_k127_8122757_1	926550.CLDAP_31420	7.938e-32	138.0	COG0454@1|root,COG0456@2|Bacteria,2G9GA@200795|Chloroflexi	200795|Chloroflexi	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
REGS1_k127_8122757_0	485913.Krac_8232	8.911e-90	309.0	COG0477@1|root,COG2814@2|Bacteria,2GBNR@200795|Chloroflexi	200795|Chloroflexi	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_81365_1	525904.Tter_0712	6.29e-185	586.0	COG0480@1|root,COG0480@2|Bacteria,2NNSV@2323|unclassified Bacteria	2|Bacteria	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0019538,GO:0030312,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
REGS1_k127_81365_3	1382356.JQMP01000003_gene2257	7.653e-55	196.0	COG0049@1|root,COG0049@2|Bacteria,2G6GR@200795|Chloroflexi,27Y66@189775|Thermomicrobia	189775|Thermomicrobia	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA	rpsG	-	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
REGS1_k127_81365_2	926569.ANT_09990	1.803e-65	227.0	COG0048@1|root,COG0048@2|Bacteria,2G6EX@200795|Chloroflexi	200795|Chloroflexi	J	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit	rpsL	-	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
REGS1_k127_81365_0	926550.CLDAP_38190	0.0	1166.0	COG0085@1|root,COG0085@2|Bacteria,2G5VH@200795|Chloroflexi	200795|Chloroflexi	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
REGS1_k127_8141892_1	1128421.JAGA01000002_gene798	2.092e-84	297.0	COG1287@1|root,COG1287@2|Bacteria	2|Bacteria	S	oligosaccharyl transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
REGS1_k127_8143024_6	1128421.JAGA01000003_gene3253	9.521e-26	117.0	COG0726@1|root,COG0726@2|Bacteria,2NPV2@2323|unclassified Bacteria	2|Bacteria	G	Polysaccharide deacetylase	-	-	3.5.1.104	ko:K22278	-	-	-	-	ko00000,ko01000	-	-	-	LysM,Polysacc_deac_1
REGS1_k127_8143024_5	1267535.KB906767_gene671	4.621e-26	115.0	COG0824@1|root,COG0824@2|Bacteria,3Y4WZ@57723|Acidobacteria,2JJIE@204432|Acidobacteriia	204432|Acidobacteriia	S	PFAM thioesterase superfamily	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2
REGS1_k127_8143024_3	926550.CLDAP_31820	8.215e-46	189.0	COG5617@1|root,COG5617@2|Bacteria	2|Bacteria	M	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_8143024_2	1121413.JMKT01000015_gene207	5.656e-46	173.0	COG1011@1|root,COG1011@2|Bacteria,1PHPQ@1224|Proteobacteria,42S23@68525|delta/epsilon subdivisions,2WNER@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Haloacid dehalogenase-like hydrolase	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
REGS1_k127_8143024_1	349161.Dred_0097	3.445e-74	261.0	COG1171@1|root,COG1171@2|Bacteria,1TP22@1239|Firmicutes,248D5@186801|Clostridia,2615A@186807|Peptococcaceae	186801|Clostridia	E	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA	ilvA	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT_4,PALP
REGS1_k127_8143024_0	926569.ANT_12970	3.772e-170	552.0	COG0323@1|root,COG0323@2|Bacteria,2G5XU@200795|Chloroflexi	200795|Chloroflexi	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	-	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
REGS1_k127_8143024_4	1089553.Tph_c26380	7.496e-45	172.0	COG0406@1|root,COG0406@2|Bacteria,1V6ES@1239|Firmicutes,24JKC@186801|Clostridia,42GW5@68295|Thermoanaerobacterales	186801|Clostridia	G	Phosphoglycerate mutase family	-	-	3.1.3.3	ko:K22305	ko00260,ko00680,ko01100,ko01120,ko01130,map00260,map00680,map01100,map01120,map01130	-	R00582	RC00017	ko00000,ko00001,ko01000	-	-	-	His_Phos_1
REGS1_k127_8153944_0	926550.CLDAP_10010	1.391e-55	212.0	COG1502@1|root,COG1502@2|Bacteria	2|Bacteria	I	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol	-	-	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2,Sulfotransfer_3
REGS1_k127_8153944_1	1128421.JAGA01000002_gene1413	2.959e-38	153.0	COG1475@1|root,COG1475@2|Bacteria	2|Bacteria	K	chromosome segregation	-	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	N6_N4_Mtase,ParBc
REGS1_k127_8153944_2	1123248.KB893327_gene796	5.597e-24	114.0	COG3292@1|root,COG4585@1|root,COG3292@2|Bacteria,COG4585@2|Bacteria,4NRVM@976|Bacteroidetes,1IQDC@117747|Sphingobacteriia	976|Bacteroidetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3,Reg_prop,Y_Y_Y
REGS1_k127_8157793_1	383372.Rcas_2505	7.977e-41	161.0	COG1807@1|root,COG1807@2|Bacteria,2G8IK@200795|Chloroflexi,375EI@32061|Chloroflexia	32061|Chloroflexia	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_8157793_2	56110.Oscil6304_1813	3.552e-21	96.0	2C4F2@1|root,331RG@2|Bacteria,1G9S1@1117|Cyanobacteria,1HDB3@1150|Oscillatoriales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_8157793_0	255470.cbdbA588	9.664e-97	321.0	COG2255@1|root,COG2255@2|Bacteria,2G5QQ@200795|Chloroflexi,34D5N@301297|Dehalococcoidia	301297|Dehalococcoidia	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
REGS1_k127_8180194_0	926569.ANT_09230	1.104e-31	143.0	COG1287@1|root,COG1287@2|Bacteria,2G8R6@200795|Chloroflexi	200795|Chloroflexi	S	oligosaccharyl transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_8180194_1	1122179.KB890413_gene4789	7.135e-21	104.0	COG1520@1|root,COG3391@1|root,COG4932@1|root,COG4935@1|root,COG1520@2|Bacteria,COG3391@2|Bacteria,COG4932@2|Bacteria,COG4935@2|Bacteria,4NN56@976|Bacteroidetes	976|Bacteroidetes	M	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,VCBS
REGS1_k127_8183366_0	485913.Krac_2637	9.142e-194	618.0	COG2208@1|root,COG2208@2|Bacteria,2G790@200795|Chloroflexi	200795|Chloroflexi	T	Stage II sporulation E family protein	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIE
REGS1_k127_8183366_1	485913.Krac_9652	1.013e-10	64.0	COG4585@1|root,COG4585@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
REGS1_k127_8184084_0	266264.Rmet_2651	2.432e-81	276.0	COG3483@1|root,COG3483@2|Bacteria,1MW68@1224|Proteobacteria,2VJG3@28216|Betaproteobacteria,1K2UU@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety	kynA	GO:0003674,GO:0003824,GO:0004833,GO:0005488,GO:0006082,GO:0006139,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009063,GO:0009072,GO:0009074,GO:0009108,GO:0009117,GO:0009165,GO:0009308,GO:0009310,GO:0009435,GO:0009987,GO:0016043,GO:0016053,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019441,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0020037,GO:0022607,GO:0034641,GO:0034654,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043436,GO:0043648,GO:0043650,GO:0043933,GO:0044085,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046218,GO:0046394,GO:0046395,GO:0046483,GO:0046496,GO:0046700,GO:0046874,GO:0046906,GO:0048037,GO:0051186,GO:0051188,GO:0051213,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0055114,GO:0065003,GO:0070189,GO:0071704,GO:0071840,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606	1.13.11.11	ko:K00453	ko00380,ko01100,map00380,map01100	M00038	R00678	RC00356	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_dioxygenase
REGS1_k127_8184084_1	926569.ANT_14180	3.635e-79	282.0	COG0617@1|root,COG0617@2|Bacteria,2G6B7@200795|Chloroflexi	200795|Chloroflexi	J	PFAM Polynucleotide adenylyltransferase region	-	-	2.7.7.19,2.7.7.72	ko:K00970,ko:K00974	ko03013,ko03018,map03013,map03018	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd,tRNA_NucTran2_2
REGS1_k127_8190007_1	1123354.AUDR01000014_gene1091	3.7e-18	91.0	COG0045@1|root,COG1042@1|root,COG1247@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG1247@2|Bacteria,1MW98@1224|Proteobacteria,2VI9R@28216|Betaproteobacteria,1KRBT@119069|Hydrogenophilales	119069|Hydrogenophilales	CM	CoA binding domain	-	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_1,CoA_binding_2,Succ_CoA_lig
REGS1_k127_8190007_0	1202768.JROF01000004_gene3181	5.752e-19	87.0	COG1975@1|root,arCOG01929@2157|Archaea,2XVCW@28890|Euryarchaeota,23W02@183963|Halobacteria	183963|Halobacteria	O	COG1975 Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI
REGS1_k127_8205087_0	221288.JH992901_gene1078	6.589e-133	433.0	COG0492@1|root,COG3437@1|root,COG0492@2|Bacteria,COG3437@2|Bacteria,1FZX5@1117|Cyanobacteria,1JHD5@1189|Stigonemataceae	1117|Cyanobacteria	KOT	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Response_reg
REGS1_k127_8205176_2	765420.OSCT_1856	3.381e-33	131.0	COG1052@1|root,COG1052@2|Bacteria,2GA73@200795|Chloroflexi,374WJ@32061|Chloroflexia	32061|Chloroflexia	CH	D-isomer specific 2-hydroxyacid dehydrogenase catalytic region	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
REGS1_k127_8205176_1	1304284.L21TH_0118	1.638e-125	411.0	COG0075@1|root,COG0075@2|Bacteria,1TPS0@1239|Firmicutes,24919@186801|Clostridia,36E72@31979|Clostridiaceae	186801|Clostridia	E	Aminotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
REGS1_k127_8205176_0	926569.ANT_00850	1.4e-212	668.0	COG1350@1|root,COG1350@2|Bacteria,2G5YY@200795|Chloroflexi	200795|Chloroflexi	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	-	-	4.2.1.20	ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
REGS1_k127_8226822_1	316274.Haur_1682	2.586e-85	295.0	COG5267@1|root,COG5267@2|Bacteria,2G7Q0@200795|Chloroflexi,376N0@32061|Chloroflexia	2|Bacteria	S	Protein of unknown function (DUF1800)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1800
REGS1_k127_8226822_0	316274.Haur_1681	1.059e-128	425.0	COG4102@1|root,COG4102@2|Bacteria,2G79B@200795|Chloroflexi,3759N@32061|Chloroflexia	200795|Chloroflexi	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
REGS1_k127_8230129_2	926550.CLDAP_34540	4.456e-52	199.0	COG1376@1|root,COG1388@1|root,COG1376@2|Bacteria,COG1388@2|Bacteria,2G6ZY@200795|Chloroflexi	200795|Chloroflexi	M	PFAM ErfK YbiS YcfS YnhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	LysM,YkuD
REGS1_k127_8230129_4	1118054.CAGW01000012_gene4006	3.157e-15	80.0	COG3502@1|root,COG3502@2|Bacteria,1V8W5@1239|Firmicutes,4HJGW@91061|Bacilli,2757W@186822|Paenibacillaceae	91061|Bacilli	S	Protein of unknown function (DUF952)	-	-	-	-	-	-	-	-	-	-	-	-	DUF952
REGS1_k127_8230129_1	1382356.JQMP01000004_gene402	2.884e-102	343.0	COG0016@1|root,COG0016@2|Bacteria,2G5T1@200795|Chloroflexi,27XFG@189775|Thermomicrobia	189775|Thermomicrobia	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
REGS1_k127_8230129_3	926550.CLDAP_14450	1.437e-40	160.0	COG3815@1|root,COG3815@2|Bacteria	2|Bacteria	S	Predicted membrane protein (DUF2085)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2085
REGS1_k127_8230129_0	926569.ANT_24980	9.988e-150	489.0	COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,2G5QR@200795|Chloroflexi	200795|Chloroflexi	J	phenylalanyl-tRNA synthetase beta subunit	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
REGS1_k127_8240562_2	66692.ABC3519	1.324e-35	156.0	COG1175@1|root,COG1175@2|Bacteria,1TR2A@1239|Firmicutes,4HB8H@91061|Bacilli,1ZBHD@1386|Bacillus	91061|Bacilli	P	COG1175 ABC-type sugar transport systems, permease components	malC	GO:0003674,GO:0003824,GO:0005215,GO:0005363,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008643,GO:0015144,GO:0015154,GO:0015157,GO:0015399,GO:0015405,GO:0015422,GO:0015423,GO:0015766,GO:0015768,GO:0015772,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0032991,GO:0034219,GO:0042623,GO:0042626,GO:0043190,GO:0043211,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990060,GO:1990351	-	ko:K15771	ko02010,map02010	M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.16,3.A.1.1.2	-	iYO844.BSU34150	BPD_transp_1
REGS1_k127_8240562_1	511051.CSE_03870	4.895e-50	188.0	COG3833@1|root,COG3833@2|Bacteria	2|Bacteria	P	maltose-transporting ATPase activity	malG	-	-	ko:K15772	ko02010,map02010	M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.16,3.A.1.1.2	-	-	BPD_transp_1
REGS1_k127_8240562_0	1121346.KB899831_gene745	1.725e-80	282.0	COG0366@1|root,COG0366@2|Bacteria,1TSEA@1239|Firmicutes,4HCXN@91061|Bacilli,2748Z@186822|Paenibacillaceae	91061|Bacilli	G	alpha-amylase	amyY	-	3.2.1.1,3.2.1.20	ko:K01176,ko:K01187	ko00052,ko00500,ko01100,ko04973,map00052,map00500,map01100,map04973	-	R00028,R00801,R00802,R02108,R02112,R06087,R06088,R11262	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH13,GH31	-	Alpha-amylase,DUF3459,Malt_amylase_C
REGS1_k127_8253039_1	933801.Ahos_0960	1.396e-53	195.0	COG1506@1|root,arCOG01646@2157|Archaea,2XQMK@28889|Crenarchaeota	28889|Crenarchaeota	E	Peptidase S9 prolyl oligopeptidase active site domain protein	apeH-1	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
REGS1_k127_8253039_0	926550.CLDAP_29190	3.074e-58	216.0	COG1316@1|root,COG1316@2|Bacteria,2G6PZ@200795|Chloroflexi	200795|Chloroflexi	K	TIGRFAM cell envelope-related function transcriptional attenuator, LytR CpsA family	-	-	-	-	-	-	-	-	-	-	-	-	LytR_C,LytR_cpsA_psr
REGS1_k127_8253039_2	243164.DET1191	3.212e-06	54.0	COG2968@1|root,COG2968@2|Bacteria,2G6UC@200795|Chloroflexi,34CTD@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Protein of unknown function (DUF541)	-	-	-	ko:K09807	-	-	-	-	ko00000	-	-	-	SIMPL
REGS1_k127_826050_7	525146.Ddes_1916	8.992e-28	117.0	COG0517@1|root,COG0517@2|Bacteria,1RA25@1224|Proteobacteria,42R80@68525|delta/epsilon subdivisions,2WMW6@28221|Deltaproteobacteria,2MARF@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM CBS domain containing protein	-	-	-	ko:K04767	-	-	-	-	ko00000	-	-	-	CBS
REGS1_k127_826050_9	313606.M23134_05603	1.845e-07	61.0	2E7WD@1|root,332B1@2|Bacteria,4P3PA@976|Bacteroidetes,47UUH@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_826050_0	926550.CLDAP_14400	3.162e-296	927.0	COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,2G65R@200795|Chloroflexi	200795|Chloroflexi	C	malic protein domain protein	-	-	1.1.1.38,1.1.1.40	ko:K00027,ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,ko02020,map00620,map00710,map01100,map01120,map01200,map02020	M00169,M00172	R00214,R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT_4,Malic_M,malic
REGS1_k127_826050_1	1380390.JIAT01000009_gene1231	3.041e-204	643.0	COG0372@1|root,COG0372@2|Bacteria,2GJ7E@201174|Actinobacteria,4CPID@84995|Rubrobacteria	84995|Rubrobacteria	C	Belongs to the citrate synthase family	-	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
REGS1_k127_826050_3	926550.CLDAP_40040	3.138e-44	170.0	COG0526@1|root,COG0526@2|Bacteria,2G737@200795|Chloroflexi	200795|Chloroflexi	CO	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	-	ko:K02199	-	-	-	-	ko00000,ko03110	-	-	-	AhpC-TSA,DnaJ
REGS1_k127_826050_6	926569.ANT_19460	7.722e-28	120.0	COG3088@1|root,COG3088@2|Bacteria,2G72W@200795|Chloroflexi	200795|Chloroflexi	O	subunit of a heme lyase	ccmH	-	-	ko:K02200	-	-	-	-	ko00000	-	-	-	CcmH
REGS1_k127_826050_4	868131.MSWAN_1998	3.207e-36	141.0	arCOG04982@1|root,arCOG04982@2157|Archaea,2XZDB@28890|Euryarchaeota,23PT5@183925|Methanobacteria	183925|Methanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_826050_5	645991.Sgly_0453	1.06e-33	136.0	COG1832@1|root,COG1832@2|Bacteria,1V7C7@1239|Firmicutes,24P0N@186801|Clostridia,2632C@186807|Peptococcaceae	186801|Clostridia	S	CoA-binding protein	-	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
REGS1_k127_826050_8	311424.DhcVS_1083	8.31e-13	78.0	COG0589@1|root,COG0589@2|Bacteria,2G91P@200795|Chloroflexi,34DF4@301297|Dehalococcoidia	301297|Dehalococcoidia	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
REGS1_k127_826050_10	379066.GAU_0822	0.0006963	48.0	29W2Z@1|root,30HMM@2|Bacteria,1ZTXQ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_826050_2	246194.CHY_1387	2.778e-170	549.0	COG1138@1|root,COG1138@2|Bacteria,1UH6S@1239|Firmicutes,24BV3@186801|Clostridia	186801|Clostridia	O	PFAM Cytochrome c assembly protein	-	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
REGS1_k127_827553_4	710685.MycrhN_2104	1.327e-05	53.0	2EHX5@1|root,33BNR@2|Bacteria,2GPW7@201174|Actinobacteria,23ARP@1762|Mycobacteriaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_827553_3	383372.Rcas_0092	4.047e-13	82.0	2BNSQ@1|root,32HG9@2|Bacteria,2G9V0@200795|Chloroflexi,37798@32061|Chloroflexia	32061|Chloroflexia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_827553_2	861299.J421_5923	1.997e-15	82.0	COG2909@1|root,COG2909@2|Bacteria	2|Bacteria	K	trisaccharide binding	-	-	-	ko:K03556	-	-	-	-	ko00000,ko03000	-	-	-	AAA_16,GerE
REGS1_k127_827553_0	1242864.D187_006159	9.653e-88	297.0	COG1428@1|root,COG1428@2|Bacteria,1NHR3@1224|Proteobacteria	1224|Proteobacteria	F	Deoxynucleoside kinase	-	-	-	-	-	-	-	-	-	-	-	-	dNK
REGS1_k127_827553_1	383372.Rcas_2353	3.117e-86	295.0	COG1131@1|root,COG1131@2|Bacteria,2G5YX@200795|Chloroflexi,3762X@32061|Chloroflexia	32061|Chloroflexia	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
REGS1_k127_827553_5	1122925.KB895393_gene1653	0.000838	46.0	COG1670@1|root,COG1670@2|Bacteria,1V8EU@1239|Firmicutes,4HJPX@91061|Bacilli,26VDI@186822|Paenibacillaceae	91061|Bacilli	J	Acetyltransferases, including N-acetylases of ribosomal proteins	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
REGS1_k127_8286599_1	926550.CLDAP_29830	5.605e-75	268.0	COG0739@1|root,COG0739@2|Bacteria	2|Bacteria	M	heme binding	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Glucosaminidase,Peptidase_M23,Peptidase_M56,SLT
REGS1_k127_8286599_0	926550.CLDAP_35020	2.734e-151	500.0	COG1387@1|root,COG1796@1|root,COG1387@2|Bacteria,COG1796@2|Bacteria,2G5K6@200795|Chloroflexi	200795|Chloroflexi	L	PHP domain protein	-	-	-	ko:K02347	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_thumb,HHH_5,HHH_8,PHP
REGS1_k127_8286599_2	1128421.JAGA01000002_gene1835	3.534e-31	126.0	COG0639@1|root,COG0639@2|Bacteria,2NPHT@2323|unclassified Bacteria	2|Bacteria	T	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos_2
REGS1_k127_8287548_7	489825.LYNGBM3L_62110	1.686e-21	99.0	COG0745@1|root,COG0745@2|Bacteria,1G1DH@1117|Cyanobacteria,1H8H2@1150|Oscillatoriales	1117|Cyanobacteria	T	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	ko:K11521	ko02020,map02020	M00465	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
REGS1_k127_8287548_5	591158.SSMG_01746	1.59e-31	139.0	COG0438@1|root,COG0438@2|Bacteria,2GM6D@201174|Actinobacteria	201174|Actinobacteria	M	PFAM Glycosyl transferase, group 1	pimB	GO:0000009,GO:0000030,GO:0003674,GO:0003824,GO:0004376,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0033164,GO:0040007,GO:0043750,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0070085,GO:0071704,GO:0071944,GO:0097502,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.4.1.346	ko:K13668	-	-	R11703,R11704	-	ko00000,ko01000,ko01003	-	GT4	-	Glyco_transf_4,Glycos_transf_1
REGS1_k127_8287548_2	635013.TherJR_1892	4.276e-73	265.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
REGS1_k127_8287548_4	28072.Nos7524_2844	1.417e-42	158.0	COG0073@1|root,COG0073@2|Bacteria,1G78D@1117|Cyanobacteria,1HNY1@1161|Nostocales	1117|Cyanobacteria	J	Export-related chaperone CsaA	-	-	-	ko:K06878	-	-	-	-	ko00000	-	-	-	tRNA_bind
REGS1_k127_8287548_1	1382306.JNIM01000001_gene894	1.485e-118	391.0	COG0438@1|root,COG0438@2|Bacteria,2G683@200795|Chloroflexi	200795|Chloroflexi	M	PFAM glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
REGS1_k127_8287548_9	1382356.JQMP01000001_gene1022	2.295e-16	87.0	COG3944@1|root,COG3944@2|Bacteria,2G7A7@200795|Chloroflexi,27YF2@189775|Thermomicrobia	189775|Thermomicrobia	M	Lipopolysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Wzz
REGS1_k127_8287548_6	316274.Haur_4007	1.458e-26	118.0	COG3944@1|root,COG3944@2|Bacteria,2G9GX@200795|Chloroflexi,375NI@32061|Chloroflexia	32061|Chloroflexia	M	PFAM lipopolysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Wzz
REGS1_k127_8287548_3	383372.Rcas_3668	8.787e-73	251.0	COG0489@1|root,COG0489@2|Bacteria,2G5WM@200795|Chloroflexi,375EN@32061|Chloroflexia	32061|Chloroflexia	D	TIGRFAM capsular exopolysaccharide family	-	-	2.7.10.2	ko:K08253	-	-	-	-	ko00000,ko01000	-	-	-	CbiA,ParA
REGS1_k127_8287548_0	324602.Caur_1968	2.539e-125	409.0	COG1209@1|root,COG1209@2|Bacteria,2G6MR@200795|Chloroflexi,375E2@32061|Chloroflexia	32061|Chloroflexia	M	PFAM Nucleotidyl transferase	-	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
REGS1_k127_8310682_0	1489678.RDMS_10970	3.619e-47	173.0	COG1028@1|root,COG1028@2|Bacteria,1WMB5@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
REGS1_k127_8313526_4	1540221.JQNI01000004_gene207	7.303e-12	68.0	COG0683@1|root,COG0683@2|Bacteria,1WIRF@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	extracellular ligand-binding receptor	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
REGS1_k127_8313526_0	871963.Desdi_3045	2.339e-80	279.0	COG0559@1|root,COG0559@2|Bacteria,1TR24@1239|Firmicutes,25BCD@186801|Clostridia	186801|Clostridia	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
REGS1_k127_8313526_1	1118054.CAGW01000061_gene2424	4.487e-77	269.0	COG4177@1|root,COG4177@2|Bacteria,1TPMZ@1239|Firmicutes,4HBB8@91061|Bacilli,26T52@186822|Paenibacillaceae	91061|Bacilli	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_2
REGS1_k127_8313526_3	257310.BB1595	3.525e-66	233.0	COG0411@1|root,COG0411@2|Bacteria,1QUC5@1224|Proteobacteria,2W0V8@28216|Betaproteobacteria,3T7H2@506|Alcaligenaceae	28216|Betaproteobacteria	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
REGS1_k127_8313526_2	1345697.M493_07625	2.287e-66	233.0	COG0410@1|root,COG0410@2|Bacteria,1TPW4@1239|Firmicutes,4HABJ@91061|Bacilli,1WGD0@129337|Geobacillus	91061|Bacilli	E	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
REGS1_k127_8328427_0	926569.ANT_13210	1.348e-208	656.0	COG2403@1|root,COG2403@2|Bacteria,2G7VS@200795|Chloroflexi	200795|Chloroflexi	S	cyclic 2,3-diphosphoglycerate synthetase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_8328427_1	118166.JH976537_gene878	2.264e-12	79.0	COG3021@1|root,COG3021@2|Bacteria,1G9UD@1117|Cyanobacteria,1HF39@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM Endonuclease Exonuclease phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
REGS1_k127_8379793_1	1128421.JAGA01000003_gene3441	2.439e-58	204.0	COG0137@1|root,COG0137@2|Bacteria,2NP01@2323|unclassified Bacteria	2|Bacteria	E	Arginosuccinate synthase	argG	GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iJN678.argG,iSB619.SA_RS04675	Arginosuc_synth
REGS1_k127_8379793_0	926569.ANT_12410	2.437e-106	353.0	COG0189@1|root,COG0189@2|Bacteria,2G5RN@200795|Chloroflexi	200795|Chloroflexi	HJ	Belongs to the RimK family	-	-	6.3.2.43	ko:K05827	ko00300,ko01100,ko01210,ko01230,map00300,map01100,map01210,map01230	M00031	R09775	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	RimK
REGS1_k127_8379793_2	1521187.JPIM01000046_gene1470	1.463e-16	80.0	2DRHT@1|root,33BTG@2|Bacteria,2G7I1@200795|Chloroflexi,37602@32061|Chloroflexia	32061|Chloroflexia	S	TIGRFAM lysine biosynthesis protein LysW	-	-	-	ko:K05826	-	M00031,M00763	-	-	ko00000,ko00001,ko00002	-	-	-	-
REGS1_k127_8411435_0	1382306.JNIM01000001_gene1536	2.992e-158	508.0	COG0620@1|root,COG0620@2|Bacteria,2G7J6@200795|Chloroflexi	200795|Chloroflexi	E	Methionine synthase vitamin-B12 independent	-	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
REGS1_k127_8411435_2	1382306.JNIM01000001_gene1538	1.399e-47	175.0	COG0599@1|root,COG0599@2|Bacteria	2|Bacteria	S	peroxiredoxin activity	pcaC	-	3.1.1.24,4.1.1.44	ko:K01055,ko:K01607,ko:K14727	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00568	R02991,R03470	RC00825,RC00938	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1,Abhydrolase_4,CMD
REGS1_k127_8411435_1	485913.Krac_5387	1.361e-72	249.0	COG4430@1|root,COG4430@2|Bacteria,2G8DH@200795|Chloroflexi	200795|Chloroflexi	S	Bacteriocin-protection, YdeI or OmpD-Associated	-	-	-	-	-	-	-	-	-	-	-	-	OmdA
REGS1_k127_8445702_2	1128421.JAGA01000003_gene2714	4.819e-40	160.0	COG4848@1|root,COG4848@2|Bacteria	2|Bacteria	L	Belongs to the UPF0354 family	ytpQ	-	-	-	-	-	-	-	-	-	-	-	DUF1444
REGS1_k127_8445702_1	1121090.KB894700_gene3295	1.095e-111	370.0	COG1024@1|root,COG1024@2|Bacteria,1TQ89@1239|Firmicutes,4IU6J@91061|Bacilli	91061|Bacilli	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	3HCDH,3HCDH_N,ECH_1,ECH_2
REGS1_k127_8445702_3	1122223.KB890688_gene1697	2.632e-39	152.0	COG2050@1|root,COG2050@2|Bacteria,1WK2I@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	Q	phenylacetic acid degradation protein PaaD	-	GO:0003674,GO:0003824,GO:0016289,GO:0016787,GO:0016788,GO:0016790	-	ko:K02614	ko00360,map00360	-	R09840	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	4HBT
REGS1_k127_8445702_0	926560.KE387026_gene4278	1.726e-126	419.0	COG1653@1|root,COG1653@2|Bacteria,1WJIN@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1
REGS1_k127_8454173_3	326427.Cagg_3784	4.645e-28	113.0	COG2894@1|root,COG2894@2|Bacteria,2G5YF@200795|Chloroflexi,375DJ@32061|Chloroflexia	32061|Chloroflexia	D	PFAM Cobyrinic acid a,c-diamide synthase	-	-	-	ko:K03609	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	CbiA
REGS1_k127_8454173_2	326427.Cagg_3783	6.277e-43	165.0	COG0850@1|root,COG0850@2|Bacteria,2G6VN@200795|Chloroflexi,375JV@32061|Chloroflexia	32061|Chloroflexia	D	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization	minC	-	-	ko:K03610	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	MinC_C,MinC_N
REGS1_k127_8454173_1	926550.CLDAP_08140	6.352e-139	470.0	COG0768@1|root,COG0768@2|Bacteria,2G64Z@200795|Chloroflexi	200795|Chloroflexi	M	PFAM penicillin-binding protein transpeptidase	-	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
REGS1_k127_8454173_0	661478.OP10G_1601	5.64e-151	484.0	COG1085@1|root,COG1085@2|Bacteria	2|Bacteria	C	galactose-1-phosphate uridylyltransferase	galT	GO:0003674,GO:0003824,GO:0004335,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006012,GO:0006793,GO:0006796,GO:0008108,GO:0008150,GO:0008152,GO:0008198,GO:0008270,GO:0009056,GO:0009987,GO:0016052,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016779,GO:0019200,GO:0019318,GO:0019320,GO:0019388,GO:0033499,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046835,GO:0046872,GO:0046914,GO:0070569,GO:0071704,GO:1901575	2.7.7.12	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	M00362,M00554,M00632	R00955	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iECUMN_1333.ECUMN_0842,iYL1228.KPN_00772	GalP_UDP_tr_C,GalP_UDP_transf
REGS1_k127_8454173_4	690850.Desaf_2331	2.108e-10	62.0	COG3335@1|root,COG3335@2|Bacteria,1P76X@1224|Proteobacteria,433G7@68525|delta/epsilon subdivisions,2WXN9@28221|Deltaproteobacteria,2MF0Q@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	manually curated	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_23
REGS1_k127_8457603_0	926569.ANT_27640	6.525e-93	308.0	COG0446@1|root,COG0446@2|Bacteria,2G6GM@200795|Chloroflexi	200795|Chloroflexi	S	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
REGS1_k127_8457603_1	882083.SacmaDRAFT_1917	4.507e-17	85.0	COG0640@1|root,COG0640@2|Bacteria,2GYV0@201174|Actinobacteria	201174|Actinobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
REGS1_k127_8457603_3	1521187.JPIM01000030_gene1495	0.0001025	49.0	COG0592@1|root,COG0592@2|Bacteria,2G641@200795|Chloroflexi,374SP@32061|Chloroflexia	32061|Chloroflexia	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	-	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
REGS1_k127_8457603_2	552811.Dehly_0949	2.28e-05	50.0	COG0592@1|root,COG0592@2|Bacteria,2G641@200795|Chloroflexi,34CUN@301297|Dehalococcoidia	301297|Dehalococcoidia	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	dnaN	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
REGS1_k127_8463885_2	1321778.HMPREF1982_02654	7.665e-24	111.0	COG0842@1|root,COG0842@2|Bacteria,1VI3K@1239|Firmicutes,24AR2@186801|Clostridia	186801|Clostridia	V	ABC-2 type transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane
REGS1_k127_8463885_0	368408.Tpen_1400	4.272e-76	267.0	COG1131@1|root,arCOG00194@2157|Archaea,2XPS7@28889|Crenarchaeota	28889|Crenarchaeota	V	PFAM ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
REGS1_k127_8463885_1	314230.DSM3645_13313	6.34e-37	146.0	2C2MA@1|root,2Z87X@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_8463885_3	1454004.AW11_02184	1.318e-19	100.0	2BDT3@1|root,327GV@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_8473197_1	1237500.ANBA01000009_gene1044	4.263e-65	233.0	COG3214@1|root,COG3214@2|Bacteria,2GJM7@201174|Actinobacteria,4EGXC@85012|Streptosporangiales	201174|Actinobacteria	S	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_42
REGS1_k127_8473197_0	485913.Krac_12385	8.962e-77	265.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	-	ko:K06219	-	-	-	-	ko00000	-	-	-	Glycos_transf_1,Glycos_transf_2,MethyTransf_Reg,Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31,TPR_2
REGS1_k127_8473197_2	1382356.JQMP01000003_gene2180	4.219e-57	206.0	COG1974@1|root,COG1974@2|Bacteria,2G6NC@200795|Chloroflexi,27Y6E@189775|Thermomicrobia	189775|Thermomicrobia	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	-	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
REGS1_k127_8473197_3	1121472.AQWN01000002_gene2149	4.499e-17	86.0	COG1466@1|root,COG1466@2|Bacteria,1TRM0@1239|Firmicutes,24ASN@186801|Clostridia,260KF@186807|Peptococcaceae	186801|Clostridia	L	TIGRFAM DNA polymerase III, delta subunit	holA	-	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta
REGS1_k127_8482349_3	335543.Sfum_4027	1.525e-62	222.0	COG0664@1|root,COG2208@1|root,COG0664@2|Bacteria,COG2208@2|Bacteria,1MXJQ@1224|Proteobacteria,42MFQ@68525|delta/epsilon subdivisions,2WIJ4@28221|Deltaproteobacteria,2MQDN@213462|Syntrophobacterales	1224|Proteobacteria	KT	Stage II sporulation	icfG	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	Cache_3-Cache_2,HAMP,HATPase_c_2,SpoIIE,dCache_1,dCache_2,sCache_2
REGS1_k127_8482349_0	1382356.JQMP01000003_gene1443	5.641e-130	443.0	COG0768@1|root,COG0768@2|Bacteria,2G7WI@200795|Chloroflexi,27Y1G@189775|Thermomicrobia	189775|Thermomicrobia	M	NTF2-like N-terminal transpeptidase domain	-	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	MecA_N,PBP_dimer,Transpeptidase
REGS1_k127_8482349_5	1121382.JQKG01000001_gene2267	3.645e-13	81.0	COG1725@1|root,COG1725@2|Bacteria	2|Bacteria	K	Transcriptional regulator	ytrA	-	-	ko:K07978,ko:K07979	-	-	-	-	ko00000,ko03000	-	-	-	GntR
REGS1_k127_8482349_4	760568.Desku_2943	3.947e-61	225.0	COG0303@1|root,COG1910@1|root,COG0303@2|Bacteria,COG1910@2|Bacteria,1TRH3@1239|Firmicutes,24ATZ@186801|Clostridia,2612F@186807|Peptococcaceae	186801|Clostridia	HP	TIGRFAM molybdenum cofactor synthesis	-	-	2.10.1.1	ko:K03750,ko:K07219	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N,PBP_like
REGS1_k127_8482349_1	479434.Sthe_3395	5.936e-91	308.0	COG2998@1|root,COG2998@2|Bacteria,2G7MD@200795|Chloroflexi,27Z56@189775|Thermomicrobia	189775|Thermomicrobia	H	PBP superfamily domain	-	-	-	ko:K05772	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	PBP_like_2
REGS1_k127_8482349_2	1128421.JAGA01000001_gene2166	2.911e-72	253.0	COG4662@1|root,COG4662@2|Bacteria,2NPF5@2323|unclassified Bacteria	2|Bacteria	H	Binding-protein-dependent transport system inner membrane component	tupB	-	-	ko:K05773	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	BPD_transp_1
REGS1_k127_8494449_0	926569.ANT_29010	1.348e-101	341.0	COG0330@1|root,COG0330@2|Bacteria,2G5SB@200795|Chloroflexi	200795|Chloroflexi	O	PFAM band 7 protein	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
REGS1_k127_8494449_2	357808.RoseRS_2782	6.478e-27	119.0	COG0500@1|root,COG2226@2|Bacteria,2G724@200795|Chloroflexi,377H0@32061|Chloroflexia	32061|Chloroflexia	H	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
REGS1_k127_8494449_1	1128421.JAGA01000001_gene2038	7.921e-93	320.0	COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,2NQ3V@2323|unclassified Bacteria	2|Bacteria	KT	COGs COG2208 Serine phosphatase RsbU regulator of sigma subunit	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	GAF,GAF_2,GGDEF,SpoIIE
REGS1_k127_8529022_2	1227487.C474_06135	1.77e-62	223.0	COG1250@1|root,arCOG00249@2157|Archaea,2XT6B@28890|Euryarchaeota,23SIF@183963|Halobacteria	183963|Halobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
REGS1_k127_8529022_1	1051632.TPY_3788	3.16e-102	342.0	COG1071@1|root,COG1071@2|Bacteria,1TQDG@1239|Firmicutes,24ZFJ@186801|Clostridia	186801|Clostridia	C	Dehydrogenase E1 component	-	-	1.2.4.4	ko:K00166	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
REGS1_k127_8529022_3	1453500.AT05_08445	4.643e-20	99.0	2ENVG@1|root,33GGJ@2|Bacteria,4P2K9@976|Bacteroidetes,1I8MZ@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_8529022_4	926562.Oweho_0994	1.777e-09	67.0	2ENVG@1|root,33GGJ@2|Bacteria,4P2K9@976|Bacteroidetes,1I8MZ@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_8529022_0	562970.Btus_1310	7.849e-133	432.0	COG0022@1|root,COG0022@2|Bacteria,1TP3J@1239|Firmicutes,4HAP6@91061|Bacilli,2788A@186823|Alicyclobacillaceae	91061|Bacilli	C	Transketolase, pyrimidine binding domain	dxpS	-	1.2.4.4	ko:K00167	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
REGS1_k127_8547850_1	565033.GACE_2162	4.648e-82	283.0	COG0863@1|root,arCOG00115@2157|Archaea,2XT30@28890|Euryarchaeota,246GU@183980|Archaeoglobi	183980|Archaeoglobi	L	DNA methylase	-	-	2.1.1.113	ko:K00590	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
REGS1_k127_8547850_0	926550.CLDAP_12360	7.376e-114	381.0	COG2723@1|root,COG2723@2|Bacteria	2|Bacteria	G	beta-glucosidase activity	-	-	3.2.1.21	ko:K05350,ko:K21000	ko00460,ko00500,ko00940,ko01100,ko01110,ko02025,map00460,map00500,map00940,map01100,map01110,map02025	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH39	-	Cellulase,Glyco_hydro_1
REGS1_k127_8594456_0	326427.Cagg_2872	4.431e-136	450.0	COG0058@1|root,COG0058@2|Bacteria,2G5KG@200795|Chloroflexi,37562@32061|Chloroflexia	32061|Chloroflexia	G	PFAM glycosyl transferase, family 35	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
REGS1_k127_86177_4	511051.CSE_12630	4.367e-33	139.0	COG1653@1|root,COG1653@2|Bacteria	2|Bacteria	G	carbohydrate transport	malE	-	-	ko:K02027,ko:K05813	ko02010,map02010	M00198,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.3	-	-	SBP_bac_8
REGS1_k127_86177_0	986075.CathTA2_1639	4.18e-198	636.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,4HFIP@91061|Bacilli	1239|Firmicutes	C	Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
REGS1_k127_86177_5	574087.Acear_1274	1.583e-15	91.0	COG1525@1|root,COG1525@2|Bacteria,1VASF@1239|Firmicutes,24G14@186801|Clostridia,3WANR@53433|Halanaerobiales	186801|Clostridia	L	nucleic acid binding	nucH	-	3.1.31.1	ko:K01174	-	-	-	-	ko00000,ko01000	-	-	-	Ada_Zn_binding,SNase
REGS1_k127_86177_2	1123389.ATXJ01000025_gene1108	3.801e-77	282.0	COG1502@1|root,COG4085@1|root,COG1502@2|Bacteria,COG4085@2|Bacteria,1WIPP@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	I	PLD-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_2
REGS1_k127_86177_3	1128421.JAGA01000003_gene2786	6.677e-50	183.0	COG1881@1|root,COG1881@2|Bacteria,2NPMM@2323|unclassified Bacteria	2|Bacteria	S	Phosphatidylethanolamine-binding protein	-	-	-	ko:K06910	-	-	-	-	ko00000	-	-	-	PBP
REGS1_k127_86177_1	926550.CLDAP_25230	3.319e-84	293.0	COG1595@1|root,COG1595@2|Bacteria,2GBP1@200795|Chloroflexi	200795|Chloroflexi	K	N-terminal 7TM region of histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HisKA_7TM
REGS1_k127_8643172_2	1499689.CCNN01000007_gene778	2.557e-30	134.0	COG4916@1|root,COG4916@2|Bacteria,1U5DA@1239|Firmicutes,25IBT@186801|Clostridia,36TID@31979|Clostridiaceae	186801|Clostridia	L	TIR domain	-	-	-	-	-	-	-	-	-	-	-	-	TIR_2
REGS1_k127_8643172_4	1550073.JROH01000026_gene985	0.0001244	53.0	COG0824@1|root,COG0824@2|Bacteria,1RHB1@1224|Proteobacteria,2UATC@28211|Alphaproteobacteria,2K4SF@204457|Sphingomonadales	204457|Sphingomonadales	S	thioesterase	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,Acyl-ACP_TE
REGS1_k127_8643172_3	598659.NAMH_0748	1.208e-11	74.0	COG0824@1|root,COG0824@2|Bacteria,1RI3X@1224|Proteobacteria,42SW5@68525|delta/epsilon subdivisions,2YPPA@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	Acyl-ACP thioesterase	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	Acyl-ACP_TE
REGS1_k127_8643172_1	296591.Bpro_4258	1.122e-38	150.0	COG1832@1|root,COG1832@2|Bacteria,1N03D@1224|Proteobacteria,2VU9G@28216|Betaproteobacteria,4AEJ7@80864|Comamonadaceae	28216|Betaproteobacteria	S	CoA binding domain	-	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
REGS1_k127_8643172_0	479434.Sthe_0597	2.262e-123	408.0	COG2905@1|root,COG4191@1|root,COG2905@2|Bacteria,COG4191@2|Bacteria,2G807@200795|Chloroflexi	200795|Chloroflexi	H	SMART ATP-binding region ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,cNMP_binding
REGS1_k127_8643257_1	479434.Sthe_1183	4.353e-127	422.0	COG4262@1|root,COG4262@2|Bacteria,2G5YS@200795|Chloroflexi	200795|Chloroflexi	S	Spermine/spermidine synthase domain	-	-	-	-	-	-	-	-	-	-	-	-	Spermine_synth
REGS1_k127_8643257_5	1096756.ATKN01000004_gene223	7.487e-20	98.0	COG4478@1|root,COG4478@2|Bacteria,2IFW4@201174|Actinobacteria,1W8XP@1268|Micrococcaceae	201174|Actinobacteria	D	TIGRFAM integral membrane protein TIGR01906	-	-	-	-	-	-	-	-	-	-	-	-	DUF1461
REGS1_k127_8643257_3	926569.ANT_30110	7.71e-42	165.0	COG0860@1|root,COG0860@2|Bacteria,2G7IE@200795|Chloroflexi	200795|Chloroflexi	M	PFAM cell wall hydrolase autolysin	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_3
REGS1_k127_8643257_0	1128421.JAGA01000002_gene432	8e-187	602.0	COG3276@1|root,COG3276@2|Bacteria,2NNQU@2323|unclassified Bacteria	2|Bacteria	J	Elongation factor SelB, winged helix	selB	-	-	ko:K03833	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,SelB-wing_2,SelB-wing_3
REGS1_k127_8643257_6	926550.CLDAP_29940	6.681e-10	71.0	COG4942@1|root,COG4942@2|Bacteria,2G960@200795|Chloroflexi	200795|Chloroflexi	D	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_8643257_4	1499967.BAYZ01000030_gene1167	6.425e-37	157.0	COG1520@1|root,COG1572@1|root,COG3210@1|root,COG1520@2|Bacteria,COG1572@2|Bacteria,COG3210@2|Bacteria,2NRGG@2323|unclassified Bacteria	2|Bacteria	U	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	-	-	1.1.2.6	ko:K05889,ko:K12678	-	-	R03136	-	ko00000,ko01000,ko02000,ko02044	1.B.12.1.1,1.B.12.1.3	-	-	CARDB,Cadherin-like,Calx-beta,Chlam_PMP,Flg_new,Lectin_legB,PQQ_2,SLH
REGS1_k127_8643257_2	1128421.JAGA01000002_gene62	3.613e-93	313.0	COG0627@1|root,COG0627@2|Bacteria,2NQQ3@2323|unclassified Bacteria	2|Bacteria	S	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
REGS1_k127_8701975_1	316274.Haur_1203	6.597e-99	331.0	COG1250@1|root,COG1250@2|Bacteria,2G6EB@200795|Chloroflexi	200795|Chloroflexi	C	3-hydroxyacyl-CoA dehydrogenase domain protein	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
REGS1_k127_8701975_5	383372.Rcas_0092	3.184e-10	71.0	2BNSQ@1|root,32HG9@2|Bacteria,2G9V0@200795|Chloroflexi,37798@32061|Chloroflexia	32061|Chloroflexia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_8701975_2	383372.Rcas_2015	2.174e-76	270.0	COG0539@1|root,COG0539@2|Bacteria,2G656@200795|Chloroflexi,3757Z@32061|Chloroflexia	32061|Chloroflexia	J	PFAM RNA binding S1 domain protein	-	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
REGS1_k127_8701975_0	243164.DET0439	8.07e-142	479.0	COG1674@1|root,COG1674@2|Bacteria,2G5XC@200795|Chloroflexi,34CZW@301297|Dehalococcoidia	301297|Dehalococcoidia	D	Ftsk_gamma	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_SpoIIIE,Ftsk_gamma
REGS1_k127_8701975_3	324602.Caur_2391	6.257e-31	123.0	COG0361@1|root,COG0361@2|Bacteria,2G70W@200795|Chloroflexi,375UY@32061|Chloroflexia	32061|Chloroflexia	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
REGS1_k127_8701975_4	335543.Sfum_1298	1.908e-15	78.0	COG1355@1|root,COG1355@2|Bacteria,1MXK5@1224|Proteobacteria,42R55@68525|delta/epsilon subdivisions,2WN4E@28221|Deltaproteobacteria,2MQCK@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Memo-like protein	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
REGS1_k127_8720034_4	1278073.MYSTI_00901	2.489e-18	86.0	COG2382@1|root,COG2382@2|Bacteria,1QX4D@1224|Proteobacteria	1224|Proteobacteria	P	Putative esterase	-	-	-	ko:K07214	-	-	-	-	ko00000	-	-	-	Esterase
REGS1_k127_8720034_3	552811.Dehly_0576	4.854e-28	119.0	COG0635@1|root,COG0635@2|Bacteria,2G5NK@200795|Chloroflexi,34CV7@301297|Dehalococcoidia	301297|Dehalococcoidia	H	Involved in the biosynthesis of porphyrin-containing compound	-	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
REGS1_k127_8720034_2	760568.Desku_0060	4.337e-42	161.0	COG0407@1|root,COG0407@2|Bacteria,1UYXW@1239|Firmicutes,25DH8@186801|Clostridia,264CR@186807|Peptococcaceae	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	2.1.1.246	ko:K14080	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00356	R09098,R10000	RC00035,RC01144,RC02440	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,URO-D
REGS1_k127_8720034_0	926550.CLDAP_19760	2.802e-62	225.0	COG0646@1|root,COG0646@2|Bacteria,2G674@200795|Chloroflexi	200795|Chloroflexi	H	Homocysteine S-methyltransferase	-	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	S-methyl_trans
REGS1_k127_8720034_1	479434.Sthe_2591	1.512e-55	203.0	COG0665@1|root,COG0665@2|Bacteria,2G6HT@200795|Chloroflexi,27XXT@189775|Thermomicrobia	189775|Thermomicrobia	E	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
REGS1_k127_8724454_0	383372.Rcas_4343	1.682e-35	157.0	COG2203@1|root,COG5002@1|root,COG2203@2|Bacteria,COG5002@2|Bacteria,2G66G@200795|Chloroflexi,3754U@32061|Chloroflexia	32061|Chloroflexia	T	SMART PAS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GAF_3,HATPase_c,HisKA,PAS
REGS1_k127_8724454_1	221288.JH992901_gene1985	9.297e-17	96.0	COG4191@1|root,COG4251@1|root,COG4191@2|Bacteria,COG4251@2|Bacteria,1G1PE@1117|Cyanobacteria	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	CBS,HATPase_c,HisKA,PAS,PAS_3,PAS_9,Response_reg
REGS1_k127_8731825_0	926569.ANT_25190	1.994e-141	460.0	COG0493@1|root,COG0493@2|Bacteria,2G6SR@200795|Chloroflexi	200795|Chloroflexi	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.18.1.2,1.19.1.1	ko:K00528	-	-	R10159	-	ko00000,ko01000	-	-	-	Pyr_redox_2
REGS1_k127_8731825_1	926569.ANT_02380	3.888e-113	373.0	COG0190@1|root,COG0190@2|Bacteria,2G6BA@200795|Chloroflexi	200795|Chloroflexi	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
REGS1_k127_8731825_2	1121920.AUAU01000002_gene2100	7.879e-100	330.0	COG2759@1|root,COG2759@2|Bacteria,3Y338@57723|Acidobacteria	57723|Acidobacteria	F	Formate--tetrahydrofolate ligase	-	-	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
REGS1_k127_8734520_2	1120999.JONM01000037_gene2109	1.14e-05	47.0	COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,1Q33X@1224|Proteobacteria,2VKF9@28216|Betaproteobacteria,2KR53@206351|Neisseriales	206351|Neisseriales	G	Pyruvate phosphate dikinase, PEP/pyruvate binding domain	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
REGS1_k127_8734520_0	574087.Acear_1293	1.797e-108	362.0	COG1363@1|root,COG1363@2|Bacteria,1TNZT@1239|Firmicutes,248D0@186801|Clostridia	186801|Clostridia	G	M42 glutamyl aminopeptidase	celM	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	Peptidase_M42
REGS1_k127_8734520_1	644966.Tmar_1691	8.431e-100	337.0	COG1363@1|root,COG1363@2|Bacteria,1TNZT@1239|Firmicutes,248D0@186801|Clostridia	186801|Clostridia	G	M42 glutamyl aminopeptidase	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	Peptidase_M42
REGS1_k127_8756831_3	83406.HDN1F_19090	1.457e-66	239.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,1RMBQ@1236|Gammaproteobacteria,1J88C@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	belongs to the aldehyde dehydrogenase family	-	-	1.2.99.10	ko:K22445	-	-	-	-	ko00000,ko01000	-	-	-	Aldedh
REGS1_k127_8756831_4	330214.NIDE3540	4.285e-49	182.0	2AKRW@1|root,31BIT@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_8756831_5	379066.GAU_3340	1.323e-45	173.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
REGS1_k127_8756831_1	1295642.H839_10713	1.761e-130	428.0	COG0183@1|root,COG0183@2|Bacteria,1TP07@1239|Firmicutes,4H9RJ@91061|Bacilli,1WG6D@129337|Geobacillus	91061|Bacilli	I	Thiolase, C-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
REGS1_k127_8756831_8	1382306.JNIM01000001_gene758	2.393e-35	146.0	COG0697@1|root,COG0697@2|Bacteria,2G8R9@200795|Chloroflexi	200795|Chloroflexi	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
REGS1_k127_8756831_0	671143.DAMO_2604	5.181e-185	607.0	COG0318@1|root,COG0318@2|Bacteria,2NPH9@2323|unclassified Bacteria	2|Bacteria	IQ	COGs COG0318 Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
REGS1_k127_8756831_9	1110697.NCAST_32_00040	1.79e-26	117.0	2BUTY@1|root,32Q5H@2|Bacteria,2HK1W@201174|Actinobacteria,4G7RY@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_8756831_7	1227349.C170_19895	1.439e-36	147.0	COG1011@1|root,COG1011@2|Bacteria,1VA29@1239|Firmicutes,4HW9S@91061|Bacilli,26R9N@186822|Paenibacillaceae	91061|Bacilli	S	Hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_8756831_6	1408424.JHYI01000014_gene1257	3.569e-39	153.0	COG1011@1|root,COG1011@2|Bacteria,1UXCJ@1239|Firmicutes,4I3FQ@91061|Bacilli,1ZP9M@1386|Bacillus	91061|Bacilli	S	HAD-hyrolase-like	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
REGS1_k127_8756831_2	479434.Sthe_0137	2.664e-121	399.0	COG1063@1|root,COG1063@2|Bacteria,2G7NV@200795|Chloroflexi,27Y3N@189775|Thermomicrobia	189775|Thermomicrobia	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
REGS1_k127_8758680_1	929712.KI912613_gene249	6.167e-140	471.0	COG0814@1|root,COG0814@2|Bacteria	2|Bacteria	E	amino acid	-	-	-	-	-	-	-	-	-	-	-	-	Trp_Tyr_perm
REGS1_k127_8758680_0	485913.Krac_7522	5.499e-142	456.0	COG1830@1|root,COG1830@2|Bacteria,2G8VI@200795|Chloroflexi	200795|Chloroflexi	G	DeoC/LacD family aldolase	-	-	4.1.2.13	ko:K11645	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	DeoC
REGS1_k127_8768905_0	1304284.L21TH_1652	1.169e-268	864.0	COG0210@1|root,COG0210@2|Bacteria,1TPSU@1239|Firmicutes,247RM@186801|Clostridia,36DGD@31979|Clostridiaceae	186801|Clostridia	L	ATP-dependent DNA helicase	pcrA	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
REGS1_k127_8799171_0	1382306.JNIM01000001_gene4011	1.804e-126	413.0	COG0541@1|root,COG0541@2|Bacteria,2G627@200795|Chloroflexi	200795|Chloroflexi	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
REGS1_k127_8799171_3	926562.Oweho_1005	1.897e-26	111.0	2E7GB@1|root,331Z4@2|Bacteria,4PE6H@976|Bacteroidetes,1ICSP@117743|Flavobacteriia,2PC0D@246874|Cryomorphaceae	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_8799171_4	309798.COPRO5265_0699	1.245e-24	107.0	COG0228@1|root,COG0228@2|Bacteria,1VA0X@1239|Firmicutes,24MND@186801|Clostridia,42GTF@68295|Thermoanaerobacterales	186801|Clostridia	J	Belongs to the bacterial ribosomal protein bS16 family	rpsP	-	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
REGS1_k127_8799171_5	871963.Desdi_2648	3.127e-14	76.0	COG1837@1|root,COG1837@2|Bacteria,1VEG7@1239|Firmicutes,24QKN@186801|Clostridia,262RX@186807|Peptococcaceae	186801|Clostridia	S	Belongs to the UPF0109 family	ylqC	-	-	ko:K06960	-	-	-	-	ko00000	-	-	-	KH_4
REGS1_k127_8799171_2	555079.Toce_1068	2.2e-37	147.0	COG0806@1|root,COG0806@2|Bacteria,1V6HD@1239|Firmicutes,24I1G@186801|Clostridia,42GJV@68295|Thermoanaerobacterales	186801|Clostridia	J	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes	rimM	-	-	ko:K02860	-	-	-	-	ko00000,ko03009	-	-	-	PRC,RimM
REGS1_k127_8799171_1	926550.CLDAP_00300	1.421e-42	160.0	COG0600@1|root,COG0600@2|Bacteria,2G6HW@200795|Chloroflexi	200795|Chloroflexi	P	PFAM binding-protein-dependent transport systems inner membrane component	-	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
REGS1_k127_8810544_3	290317.Cpha266_1159	7.265e-18	86.0	COG2738@1|root,COG2738@2|Bacteria,1FEE1@1090|Chlorobi	1090|Chlorobi	S	PFAM peptidase, membrane zinc metallopeptidase	-	-	-	ko:K06973	-	-	-	-	ko00000	-	-	-	Zn_peptidase_2
REGS1_k127_8810544_0	926560.KE387027_gene1003	1.243e-91	311.0	COG0656@1|root,COG0656@2|Bacteria,1WIXH@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
REGS1_k127_8810544_2	1121377.KB906402_gene3274	1.139e-43	176.0	COG4221@1|root,COG4221@2|Bacteria,1WIDQ@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short
REGS1_k127_8810544_1	867845.KI911784_gene1973	1.063e-73	260.0	COG0647@1|root,COG0647@2|Bacteria,2G6G5@200795|Chloroflexi,375IP@32061|Chloroflexia	32061|Chloroflexia	G	Belongs to the HAD-like hydrolase superfamily	-	-	3.1.3.41	ko:K01101	ko00627,ko01120,map00627,map01120	-	R03024	RC00151	ko00000,ko00001,ko01000	-	-	-	Hydrolase_6,Hydrolase_like
REGS1_k127_8810544_4	477974.Daud_1411	9.603e-17	82.0	COG0762@1|root,COG0762@2|Bacteria,1URMB@1239|Firmicutes,24RBP@186801|Clostridia,2633K@186807|Peptococcaceae	186801|Clostridia	S	YGGT family	-	-	-	ko:K02221	-	-	-	-	ko00000,ko02044	-	-	-	YGGT
REGS1_k127_8812332_3	926550.CLDAP_04520	7.483e-36	144.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,2G5Y8@200795|Chloroflexi	200795|Chloroflexi	H	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
REGS1_k127_8812332_1	479434.Sthe_2125	1.587e-78	276.0	COG1721@1|root,COG1721@2|Bacteria,2G6Y7@200795|Chloroflexi,27YYN@189775|Thermomicrobia	189775|Thermomicrobia	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
REGS1_k127_8812332_0	485913.Krac_8718	3.305e-122	399.0	COG0714@1|root,COG0714@2|Bacteria,2G669@200795|Chloroflexi	200795|Chloroflexi	S	ATPase associated with various cellular activities, AAA_3	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
REGS1_k127_8812332_2	485913.Krac_8704	1.851e-51	191.0	28I4Y@1|root,2Z88D@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_8835654_7	1408254.T458_19885	1.169e-51	193.0	COG1402@1|root,COG1402@2|Bacteria,1V0N8@1239|Firmicutes,4HK2P@91061|Bacilli,276QJ@186822|Paenibacillaceae	91061|Bacilli	S	Creatinine amidohydrolase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
REGS1_k127_8835654_12	485913.Krac_2843	1.214e-08	63.0	COG2318@1|root,COG2318@2|Bacteria	2|Bacteria	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
REGS1_k127_8835654_13	225937.HP15_279	3.951e-07	59.0	2EI3W@1|root,33BVA@2|Bacteria,1NPW4@1224|Proteobacteria,1SGBC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_8835654_1	35841.BT1A1_1328	6.26e-138	455.0	COG0318@1|root,COG0318@2|Bacteria,1TPSX@1239|Firmicutes,4HB3V@91061|Bacilli,1ZB8V@1386|Bacillus	91061|Bacilli	IQ	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
REGS1_k127_8835654_3	926569.ANT_26470	1.586e-79	280.0	COG2848@1|root,COG2848@2|Bacteria,2G6HQ@200795|Chloroflexi	200795|Chloroflexi	S	Uncharacterised ACR (DUF711)	-	-	-	ko:K09157	-	-	-	-	ko00000	-	-	-	DUF711
REGS1_k127_8835654_0	518766.Rmar_1548	3.851e-183	590.0	COG1086@1|root,COG1086@2|Bacteria	2|Bacteria	GM	Polysaccharide biosynthesis protein	-	-	2.7.8.33,2.7.8.35	ko:K02851	-	-	R08856	RC00002	ko00000,ko01000,ko01003,ko01005	-	-	-	Bac_transf,CoA_binding_3,Glycos_transf_4,HTH_45,LicD
REGS1_k127_8835654_10	387631.Asulf_01413	5.36e-16	83.0	arCOG04141@1|root,arCOG04141@2157|Archaea	2157|Archaea	S	Protein of unknown function (DUF2283)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2283
REGS1_k127_8835654_5	1122217.KB899601_gene1535	1.739e-63	226.0	COG0357@1|root,COG0357@2|Bacteria,1TPBT@1239|Firmicutes,4H2EW@909932|Negativicutes	909932|Negativicutes	J	Specifically methylates the N7 position of a guanine in 16S rRNA	rsmG	-	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB
REGS1_k127_8835654_4	479434.Sthe_3404	2.215e-78	275.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1,Glycos_transf_2
REGS1_k127_8835654_2	309801.trd_1791	2.766e-130	428.0	COG1092@1|root,COG1092@2|Bacteria,2G5YR@200795|Chloroflexi	200795|Chloroflexi	J	SMART PUA domain containing protein	-	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
REGS1_k127_8835654_8	82995.CR62_17675	8.261e-43	169.0	COG0697@1|root,COG0697@2|Bacteria,1REB0@1224|Proteobacteria,1RU4Z@1236|Gammaproteobacteria,400TK@613|Serratia	1236|Gammaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
REGS1_k127_8835654_6	203119.Cthe_1805	9.188e-53	198.0	COG2199@1|root,COG3706@2|Bacteria,1UHZ8@1239|Firmicutes,25E7W@186801|Clostridia,3WGN1@541000|Ruminococcaceae	186801|Clostridia	T	Diguanylate cyclase, GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Response_reg
REGS1_k127_8835654_9	111781.Lepto7376_1314	3.392e-16	84.0	COG0745@1|root,COG0745@2|Bacteria,1G1DH@1117|Cyanobacteria,1H8H2@1150|Oscillatoriales	1117|Cyanobacteria	T	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	ko:K11521	ko02020,map02020	M00465	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
REGS1_k127_8870056_2	383372.Rcas_1263	1.883e-39	152.0	COG1077@1|root,COG1077@2|Bacteria,2G5KV@200795|Chloroflexi,374UP@32061|Chloroflexia	32061|Chloroflexia	D	TIGRFAM cell shape determining protein, MreB Mrl family	-	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
REGS1_k127_8870056_3	316274.Haur_4073	1.967e-36	143.0	COG0355@1|root,COG0355@2|Bacteria,2G70H@200795|Chloroflexi,375QG@32061|Chloroflexia	32061|Chloroflexia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE,ATP-synt_DE_N
REGS1_k127_8870056_0	479434.Sthe_1421	7.209e-233	728.0	COG0055@1|root,COG0055@2|Bacteria,2G5JI@200795|Chloroflexi,27XYE@189775|Thermomicrobia	189775|Thermomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
REGS1_k127_8870056_1	525904.Tter_0064	2.706e-79	274.0	COG0224@1|root,COG0224@2|Bacteria,2NP76@2323|unclassified Bacteria	2|Bacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030312,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0040007,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	iLJ478.TM1611,iSSON_1240.SSON_3886,iYL1228.KPN_04138	ATP-synt
REGS1_k127_8872217_1	357808.RoseRS_0243	1.001e-13	85.0	COG4745@1|root,COG4745@2|Bacteria,2G6HI@200795|Chloroflexi,374ZD@32061|Chloroflexia	32061|Chloroflexia	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
REGS1_k127_8872217_0	1382356.JQMP01000004_gene288	1.216e-41	162.0	COG4745@1|root,COG4745@2|Bacteria,2G6HI@200795|Chloroflexi,27XK8@189775|Thermomicrobia	189775|Thermomicrobia	O	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
REGS1_k127_88975_1	479434.Sthe_0890	1.152e-83	287.0	COG1215@1|root,COG1215@2|Bacteria,2G6E4@200795|Chloroflexi,27Z3C@189775|Thermomicrobia	189775|Thermomicrobia	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
REGS1_k127_88975_0	404589.Anae109_0714	4.492e-116	392.0	COG1215@1|root,COG1215@2|Bacteria,1MX08@1224|Proteobacteria,42MS6@68525|delta/epsilon subdivisions,2WIYE@28221|Deltaproteobacteria,2YUMA@29|Myxococcales	28221|Deltaproteobacteria	M	Glycosyl transferase family 21	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3
REGS1_k127_88975_5	1485543.JMME01000003_gene2019	4.883e-28	119.0	COG1196@1|root,COG1196@2|Bacteria,1VAV4@1239|Firmicutes,4H4PK@909932|Negativicutes	909932|Negativicutes	D	Protein of unknown function (DUF4446)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4446
REGS1_k127_88975_2	383372.Rcas_4061	2.596e-60	215.0	COG0127@1|root,COG0127@2|Bacteria,2G6GK@200795|Chloroflexi,375KJ@32061|Chloroflexia	32061|Chloroflexia	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	-	-	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
REGS1_k127_88975_4	485913.Krac_1087	9.77e-53	195.0	COG0639@1|root,COG0639@2|Bacteria	2|Bacteria	T	phosphoprotein phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos_2
REGS1_k127_88975_3	926550.CLDAP_09500	1.756e-59	210.0	COG2318@1|root,COG2318@2|Bacteria,2G91B@200795|Chloroflexi	200795|Chloroflexi	S	Protein of unknown function (DUF664)	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
REGS1_k127_8922081_3	370438.PTH_1843	2.656e-47	175.0	COG1327@1|root,COG1327@2|Bacteria,1V3JA@1239|Firmicutes,24HFT@186801|Clostridia,261UI@186807|Peptococcaceae	186801|Clostridia	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	-	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
REGS1_k127_8922081_0	926569.ANT_23480	0.0	1078.0	COG0209@1|root,COG0209@2|Bacteria,2G5PW@200795|Chloroflexi	200795|Chloroflexi	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdA	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Intein_splicing,Ribonuc_red_lgC,Ribonuc_red_lgN,TSCPD
REGS1_k127_8922081_1	926550.CLDAP_09730	5.848e-96	332.0	COG3920@1|root,COG3920@2|Bacteria	2|Bacteria	T	Histidine kinase	pdtaS	-	2.1.1.80,2.7.13.3,3.1.1.61,3.1.4.52,3.6.3.17	ko:K00936,ko:K02030,ko:K10441,ko:K13924,ko:K20962	ko02010,ko02020,ko02030,ko05111,map02010,map02020,map02030,map05111	M00212,M00236,M00506,M00839	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02000,ko02022,ko02035	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19,3.A.1.3	-	-	GAF,HATPase_c,HATPase_c_2,H_kinase_N,HisKA_2,PAS,PAS_3,PAS_4,PAS_9,Response_reg,TPR_12,TPR_8
REGS1_k127_8922081_2	324602.Caur_1997	1.921e-83	283.0	COG3707@1|root,COG3707@2|Bacteria,2G6CD@200795|Chloroflexi,374XC@32061|Chloroflexia	32061|Chloroflexia	T	PFAM response regulator receiver	-	-	-	ko:K22010	-	M00839	-	-	ko00000,ko00002,ko02022	-	-	-	ANTAR,Response_reg
REGS1_k127_8922081_4	1499967.BAYZ01000068_gene1934	2.268e-09	61.0	COG5434@1|root,COG5434@2|Bacteria	2|Bacteria	M	polygalacturonase activity	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,F5_F8_type_C,Glyco_hydro_28,Pectate_lyase_3,SdiA-regulated
REGS1_k127_8934349_9	997296.PB1_10814	1.402e-08	57.0	COG2963@1|root,COG2963@2|Bacteria,1VCUH@1239|Firmicutes,4HKUP@91061|Bacilli,1ZJQY@1386|Bacillus	91061|Bacilli	L	COG2963 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_1
REGS1_k127_8934349_10	1089553.Tph_c14770	8.758e-06	48.0	COG2801@1|root,COG2963@1|root,COG2801@2|Bacteria,COG2963@2|Bacteria,1TRNK@1239|Firmicutes,24B7I@186801|Clostridia,42G6M@68295|Thermoanaerobacterales	186801|Clostridia	L	HTH-like domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,HTH_Tnp_1,rve,rve_3
REGS1_k127_8934349_3	264732.Moth_2229	1.097e-115	378.0	COG2801@1|root,COG2801@2|Bacteria,1TRNK@1239|Firmicutes,24B7I@186801|Clostridia,42G6M@68295|Thermoanaerobacterales	186801|Clostridia	L	HTH-like domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,HTH_Tnp_1,rve,rve_3
REGS1_k127_8934349_4	309801.trd_0490	7.501e-48	184.0	COG0392@1|root,COG0392@2|Bacteria,2G5KF@200795|Chloroflexi,27Y04@189775|Thermomicrobia	189775|Thermomicrobia	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
REGS1_k127_8934349_6	525904.Tter_0606	1.405e-28	126.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	yodP	-	2.3.1.264	ko:K21935	-	-	R11701	-	ko00000,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_9
REGS1_k127_8934349_0	926569.ANT_20580	2.509e-137	447.0	COG0045@1|root,COG0045@2|Bacteria,2G68A@200795|Chloroflexi	200795|Chloroflexi	F	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
REGS1_k127_8934349_1	1128421.JAGA01000002_gene1381	2.738e-133	437.0	COG0624@1|root,COG0624@2|Bacteria,2NQ4M@2323|unclassified Bacteria	2|Bacteria	E	Peptidase family M20/M25/M40	-	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28,Peptidase_M42
REGS1_k127_8934349_5	1379281.AVAG01000038_gene777	1.081e-29	124.0	COG0537@1|root,COG0537@2|Bacteria,1PDTP@1224|Proteobacteria,42UAD@68525|delta/epsilon subdivisions,2WQRN@28221|Deltaproteobacteria,2MBWX@213115|Desulfovibrionales	28221|Deltaproteobacteria	FG	Scavenger mRNA decapping enzyme C-term binding	-	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
REGS1_k127_8934349_7	1128421.JAGA01000002_gene1796	1.474e-25	115.0	COG2852@1|root,COG2852@2|Bacteria	2|Bacteria	L	Protein conserved in bacteria	-	-	2.1.1.72	ko:K07316	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	DUF559
REGS1_k127_8934349_2	479434.Sthe_1784	1.319e-127	416.0	COG0074@1|root,COG0074@2|Bacteria,2G5R4@200795|Chloroflexi,27XS4@189775|Thermomicrobia	189775|Thermomicrobia	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA
REGS1_k127_8943934_3	696281.Desru_2408	8.745e-09	57.0	COG4303@1|root,COG4303@2|Bacteria,1TP15@1239|Firmicutes,248P5@186801|Clostridia,260JB@186807|Peptococcaceae	186801|Clostridia	E	PFAM Ethanolamine ammonia lyase large subunit	eutB	-	4.3.1.7	ko:K03735	ko00564,ko01100,map00564,map01100	-	R00749	RC00370	ko00000,ko00001,ko01000	-	-	-	EutB
REGS1_k127_8943934_2	867845.KI911784_gene1050	1.114e-49	183.0	2CMS6@1|root,32SFE@2|Bacteria,2G905@200795|Chloroflexi,377IA@32061|Chloroflexia	32061|Chloroflexia	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
REGS1_k127_8943934_0	1203605.HMPREF1531_00750	7.549e-94	319.0	COG4302@1|root,COG4302@2|Bacteria,2IB7Y@201174|Actinobacteria,4DT8C@85009|Propionibacteriales	201174|Actinobacteria	E	Ethanolamine ammonia-lyase light chain (EutC)	eutC	-	4.3.1.7	ko:K03736	ko00564,ko01100,map00564,map01100	-	R00749	RC00370	ko00000,ko00001,ko01000	-	-	-	EutC
REGS1_k127_8943934_1	926569.ANT_07210	5.305e-88	295.0	COG4816@1|root,COG4816@2|Bacteria	2|Bacteria	E	ethanolamine catabolic process	eutL	GO:0003674,GO:0005198,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0008270,GO:0031469,GO:0031471,GO:0042802,GO:0043167,GO:0043169,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044464,GO:0046872,GO:0046914	-	ko:K04026	-	-	-	-	ko00000	-	-	-	BMC
REGS1_k127_8974849_0	479434.Sthe_2950	3.878e-66	228.0	COG1350@1|root,COG1350@2|Bacteria,2G5YY@200795|Chloroflexi,27XSD@189775|Thermomicrobia	189775|Thermomicrobia	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	-	-	4.2.1.20	ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
REGS1_k127_8974849_2	926550.CLDAP_12950	6.187e-23	103.0	COG3695@1|root,COG3695@2|Bacteria,2G7CY@200795|Chloroflexi	200795|Chloroflexi	L	PFAM Methylated-DNA- protein -cysteine S-methyltransferase DNA binding	-	-	-	ko:K07443	-	-	-	-	ko00000	-	-	-	DNA_binding_1
REGS1_k127_8974849_1	357808.RoseRS_1324	7.388e-55	198.0	COG3335@1|root,COG3335@2|Bacteria,2G8GI@200795|Chloroflexi,377BY@32061|Chloroflexia	32061|Chloroflexia	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3
REGS1_k127_8987150_0	502025.Hoch_1497	1.366e-25	123.0	COG1524@1|root,COG1524@2|Bacteria,1MYH0@1224|Proteobacteria,42QJN@68525|delta/epsilon subdivisions,2WXWZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
REGS1_k127_8990914_4	926550.CLDAP_35100	6.624e-53	194.0	COG1721@1|root,COG1721@2|Bacteria,2G5XH@200795|Chloroflexi	200795|Chloroflexi	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
REGS1_k127_8990914_1	926550.CLDAP_35090	4.341e-141	454.0	COG0714@1|root,COG0714@2|Bacteria,2G66D@200795|Chloroflexi	200795|Chloroflexi	S	ATPase associated with various cellular activities, AAA_3	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
REGS1_k127_8990914_0	926569.ANT_01210	1.09e-185	590.0	COG0402@1|root,COG0402@2|Bacteria,2G5X1@200795|Chloroflexi	200795|Chloroflexi	F	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
REGS1_k127_8990914_2	1304885.AUEY01000104_gene2548	2.459e-114	377.0	COG0702@1|root,COG0702@2|Bacteria,1Q438@1224|Proteobacteria,439WM@68525|delta/epsilon subdivisions,2X29K@28221|Deltaproteobacteria,2MPBK@213118|Desulfobacterales	28221|Deltaproteobacteria	GM	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10
REGS1_k127_8990914_5	251229.Chro_4480	1.663e-48	180.0	COG1670@1|root,COG1670@2|Bacteria,1G5DD@1117|Cyanobacteria,3VK96@52604|Pleurocapsales	1117|Cyanobacteria	J	COGs COG1670 Acetyltransferase including N-acetylase of ribosomal protein	-	-	2.3.1.128	ko:K03790	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_3
REGS1_k127_8990914_6	1128421.JAGA01000003_gene2941	6.226e-22	105.0	COG0346@1|root,COG0346@2|Bacteria,2NRR7@2323|unclassified Bacteria	2|Bacteria	E	Glyoxalase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase_3
REGS1_k127_8990914_3	926569.ANT_04720	3.196e-79	272.0	COG1744@1|root,COG1744@2|Bacteria,2G6CN@200795|Chloroflexi	200795|Chloroflexi	M	ABC transporter substrate-binding protein PnrA-like	-	-	-	ko:K02058,ko:K07335	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	Bmp
REGS1_k127_8991364_0	644282.Deba_3229	1.723e-211	672.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,42M9W@68525|delta/epsilon subdivisions,2WJ29@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
REGS1_k127_8991364_1	479434.Sthe_0827	3.077e-181	592.0	COG0613@1|root,COG2865@1|root,COG0613@2|Bacteria,COG2865@2|Bacteria,2G5UU@200795|Chloroflexi	200795|Chloroflexi	K	SMART phosphoesterase PHP domain protein	-	-	-	-	-	-	-	-	-	-	-	-	AlbA_2,PHP
REGS1_k127_8991364_3	1416752.AYME01000010_gene356	3.965e-21	106.0	COG1388@1|root,COG1388@2|Bacteria,2I3X4@201174|Actinobacteria,4FMDC@85023|Microbacteriaceae	201174|Actinobacteria	M	Lysin motif	-	-	-	-	-	-	-	-	-	-	-	-	LysM
REGS1_k127_8991364_2	525904.Tter_0551	1.101e-93	315.0	COG3294@1|root,COG3294@2|Bacteria,2NR9E@2323|unclassified Bacteria	2|Bacteria	S	PFAM metal-dependent phosphohydrolase HD sub domain	-	-	-	ko:K09163	-	-	-	-	ko00000	-	-	-	HD
REGS1_k127_8994674_2	765420.OSCT_2742	7.178e-54	199.0	COG1262@1|root,COG1262@2|Bacteria	2|Bacteria	T	PFAM Formylglycine-generating sulfatase enzyme	-	-	1.14.99.50	ko:K18912	ko00340,map00340	-	R11013	RC03323,RC03324	ko00000,ko00001,ko01000	-	-	-	FGE-sulfatase,Pkinase
REGS1_k127_8994674_1	324602.Caur_0607	1.291e-147	487.0	COG0471@1|root,COG0490@1|root,COG0471@2|Bacteria,COG0490@2|Bacteria,2G7T5@200795|Chloroflexi	200795|Chloroflexi	P	PFAM Citrate transporter	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,TrkA_C
REGS1_k127_8994674_0	671143.DAMO_2604	1.398e-184	593.0	COG0318@1|root,COG0318@2|Bacteria,2NPH9@2323|unclassified Bacteria	2|Bacteria	IQ	COGs COG0318 Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
REGS1_k127_8994674_3	1122917.KB899666_gene3387	7.532e-42	161.0	COG5470@1|root,COG5470@2|Bacteria,1VSV2@1239|Firmicutes,4HUUN@91061|Bacilli,26X9M@186822|Paenibacillaceae	91061|Bacilli	S	NIPSNAP family containing protein	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_9014380_0	429009.Adeg_2057	1.816e-230	726.0	COG2759@1|root,COG2759@2|Bacteria,1TP6N@1239|Firmicutes,247P5@186801|Clostridia,42FHK@68295|Thermoanaerobacterales	186801|Clostridia	F	PFAM formate-tetrahydrofolate ligase FTHFS	fhs	-	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
REGS1_k127_9014380_1	7091.BGIBMGA002355-TA	7.852e-09	57.0	COG0190@1|root,KOG0089@2759|Eukaryota,38DGG@33154|Opisthokonta,3B98B@33208|Metazoa,3CT16@33213|Bilateria,41TQN@6656|Arthropoda,3SHF7@50557|Insecta,443TG@7088|Lepidoptera	33208|Metazoa	H	Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain	Nmdmc	GO:0000287,GO:0003674,GO:0003824,GO:0004477,GO:0004487,GO:0004488,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005975,GO:0006082,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009256,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0019752,GO:0034641,GO:0042301,GO:0042558,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043603,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046653,GO:0046872,GO:0051186,GO:0055114,GO:0071704,GO:1901360,GO:1901564	1.1.1.79,1.1.1.81,1.5.1.15,3.5.4.9	ko:K00049,ko:K13403	ko00260,ko00620,ko00630,ko00670,ko01100,ko01110,ko01120,map00260,map00620,map00630,map00670,map01100,map01110,map01120	M00141	R00465,R01218,R01388,R01392,R01655,R02527	RC00031,RC00042,RC00202,RC00578,RC00670	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
REGS1_k127_9019231_6	517418.Ctha_0492	1.583e-18	99.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	lphB	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_22
REGS1_k127_9019231_1	243233.MCA1900	8.778e-93	314.0	COG1230@1|root,COG1230@2|Bacteria,1MVQB@1224|Proteobacteria,1RMR8@1236|Gammaproteobacteria,1XF2R@135618|Methylococcales	135618|Methylococcales	P	Cation efflux family	-	-	-	ko:K16264	-	-	-	-	ko00000,ko02000	2.A.4.1	-	-	Cation_efflux
REGS1_k127_9019231_5	1173022.Cri9333_1260	1.706e-37	142.0	COG1742@1|root,COG1742@2|Bacteria,1G7QM@1117|Cyanobacteria,1HFR1@1150|Oscillatoriales	1117|Cyanobacteria	S	Uncharacterised BCR, YnfA/UPF0060 family	-	-	-	ko:K09771	-	-	-	-	ko00000,ko02000	2.A.7.26	-	-	UPF0060
REGS1_k127_9019231_4	1048834.TC41_1800	3.122e-40	156.0	COG0053@1|root,COG0053@2|Bacteria,1V9B6@1239|Firmicutes,4HJTJ@91061|Bacilli	91061|Bacilli	P	Cation efflux family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux
REGS1_k127_9019231_7	1041146.ATZB01000012_gene3150	1.013e-14	81.0	COG2020@1|root,COG2020@2|Bacteria,1RECR@1224|Proteobacteria,2U6MH@28211|Alphaproteobacteria,4BA0U@82115|Rhizobiaceae	28211|Alphaproteobacteria	O	Isoprenylcysteine carboxyl methyltransferase (ICMT) family	-	-	-	-	-	-	-	-	-	-	-	-	ICMT,PEMT
REGS1_k127_9019231_2	1382306.JNIM01000001_gene1471	7.547e-76	265.0	COG0589@1|root,COG0589@2|Bacteria,2G8FB@200795|Chloroflexi	200795|Chloroflexi	T	Belongs to the universal stress protein A family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
REGS1_k127_9019231_0	1382306.JNIM01000001_gene1470	1.078e-185	590.0	COG1914@1|root,COG1914@2|Bacteria,2G67K@200795|Chloroflexi	200795|Chloroflexi	P	H( )-stimulated, divalent metal cation uptake system	mntH	-	-	ko:K03322	-	-	-	-	ko00000,ko02000	2.A.55.2.6,2.A.55.3	-	-	Nramp
REGS1_k127_9019231_3	383372.Rcas_3322	7.006e-63	223.0	COG1321@1|root,COG1918@1|root,COG1321@2|Bacteria,COG1918@2|Bacteria,2G6N4@200795|Chloroflexi,375K6@32061|Chloroflexia	32061|Chloroflexia	K	iron dependent repressor	-	-	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,Fe_dep_repress,FeoA
REGS1_k127_9021859_1	926550.CLDAP_38200	2.615e-83	280.0	COG0086@1|root,COG0086@2|Bacteria,2G632@200795|Chloroflexi	200795|Chloroflexi	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
REGS1_k127_9021859_0	926550.CLDAP_38190	1.471e-227	717.0	COG0085@1|root,COG0085@2|Bacteria,2G5VH@200795|Chloroflexi	200795|Chloroflexi	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
REGS1_k127_9024023_4	526227.Mesil_3344	1.744e-46	175.0	COG5295@1|root,COG5295@2|Bacteria	2|Bacteria	UW	Hep Hag repeat protein	yeeJ	-	-	ko:K21449	-	-	-	-	ko00000,ko02000	1.B.40.2	-	-	DUF5122,Peptidase_S74,YadA_head,YadA_stalk
REGS1_k127_9024023_6	243231.GSU2508	5.51e-26	125.0	COG0457@1|root,COG0457@2|Bacteria,1NNJ6@1224|Proteobacteria,42PBD@68525|delta/epsilon subdivisions,2WKWJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
REGS1_k127_9024023_5	867845.KI911784_gene275	1.761e-27	121.0	COG1719@1|root,COG1719@2|Bacteria,2G8D0@200795|Chloroflexi,375HS@32061|Chloroflexia	32061|Chloroflexia	S	4-vinyl reductase, 4VR	-	-	-	-	-	-	-	-	-	-	-	-	V4R
REGS1_k127_9024023_0	926569.ANT_06780	4.737e-73	252.0	COG2229@1|root,COG2229@2|Bacteria,2G8FZ@200795|Chloroflexi	200795|Chloroflexi	S	TIGRFAM small GTP-binding protein	-	-	-	ko:K06945	-	-	-	-	ko00000	-	-	-	ATP_bind_1
REGS1_k127_9024023_1	926569.ANT_06790	1.791e-69	244.0	COG0457@1|root,COG0457@2|Bacteria,2G770@200795|Chloroflexi	200795|Chloroflexi	S	Domain of unknown function (DUF4388)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4388
REGS1_k127_9024023_3	324602.Caur_3810	4.64e-59	233.0	COG5305@1|root,COG5305@2|Bacteria,2GAHI@200795|Chloroflexi,3765S@32061|Chloroflexia	32061|Chloroflexia	S	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_9024023_2	1521187.JPIM01000036_gene2533	6.761e-65	224.0	COG4214@1|root,COG4214@2|Bacteria,2G8H9@200795|Chloroflexi,376ZS@32061|Chloroflexia	32061|Chloroflexia	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K10547	ko02010,map02010	M00216	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.5	-	-	BPD_transp_2
REGS1_k127_9033853_2	1045009.AFXQ01000007_gene2956	4.618e-07	53.0	COG1108@1|root,COG1108@2|Bacteria,2GJ7H@201174|Actinobacteria,1W7XM@1268|Micrococcaceae	201174|Actinobacteria	P	ABC 3 transport family	mntB	-	-	ko:K09819,ko:K11602,ko:K19975,ko:K19976	ko02010,ko02020,map02010,map02020	M00243,M00316,M00792	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15,3.A.1.15.1,3.A.1.15.15	-	-	ABC-3
REGS1_k127_9033853_1	511051.CSE_05140	1.204e-34	141.0	COG0671@1|root,COG0671@2|Bacteria	2|Bacteria	I	phosphatidate phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	PAP2,PAP2_3
REGS1_k127_9033853_0	1173022.Cri9333_1991	1.56e-38	150.0	COG0614@1|root,COG0614@2|Bacteria,1G71C@1117|Cyanobacteria,1HBXK@1150|Oscillatoriales	1117|Cyanobacteria	P	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_3
REGS1_k127_9044395_2	1128421.JAGA01000002_gene123	3.958e-47	172.0	COG0297@1|root,COG0297@2|Bacteria,2NP1F@2323|unclassified Bacteria	2|Bacteria	G	Synthesizes alpha-1,4-glucan chains using ADP-glucose	glgA	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009011,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0046527,GO:0055114,GO:0071704,GO:1901576	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	iLJ478.TM0895	Glyco_transf_5,Glycos_transf_1
REGS1_k127_9044395_0	926569.ANT_06870	1.646e-73	259.0	COG0111@1|root,COG0111@2|Bacteria,2G6KY@200795|Chloroflexi	200795|Chloroflexi	C	D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding	-	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh,2-Hacid_dh_C
REGS1_k127_9044395_1	319795.Dgeo_1796	2.467e-71	249.0	COG0739@1|root,COG0739@2|Bacteria,1WM9M@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
REGS1_k127_9044395_3	1122221.JHVI01000007_gene2245	9.646e-45	179.0	COG0739@1|root,COG0739@2|Bacteria,1WM9M@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
REGS1_k127_9049072_1	383372.Rcas_1195	4.29e-21	97.0	COG1366@1|root,COG2172@1|root,COG1366@2|Bacteria,COG2172@2|Bacteria,2G93H@200795|Chloroflexi,375J3@32061|Chloroflexia	32061|Chloroflexia	T	PFAM Sulfate transporter antisigma-factor antagonist STAS	-	-	2.7.11.1	ko:K04749,ko:K04757	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	HATPase_c_2,STAS
REGS1_k127_9049072_2	1128421.JAGA01000001_gene2037	2.497e-17	86.0	COG1366@1|root,COG2172@1|root,COG1366@2|Bacteria,COG2172@2|Bacteria,2NRQE@2323|unclassified Bacteria	2|Bacteria	T	Histidine kinase-like ATPase domain	-	-	2.7.11.1	ko:K04749,ko:K04757	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	HATPase_c_2,STAS,STAS_2
REGS1_k127_9049072_0	357808.RoseRS_2162	1.032e-100	358.0	COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,2G790@200795|Chloroflexi,3750C@32061|Chloroflexia	32061|Chloroflexia	T	SMART protein phosphatase 2C domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,SpoIIE
REGS1_k127_9079694_9	35754.JNYJ01000011_gene777	6.984e-23	106.0	COG4833@1|root,COG4833@2|Bacteria	2|Bacteria	G	Hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_92,Lipase_GDSL_2,RicinB_lectin_2,Ricin_B_lectin
REGS1_k127_9079694_11	1298863.AUEP01000017_gene4111	2.922e-06	59.0	COG0392@1|root,COG0392@2|Bacteria,2HYHA@201174|Actinobacteria,4DUZD@85009|Propionibacteriales	201174|Actinobacteria	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	-	-	-	-	-	-	-	-	-	LPG_synthase_TM
REGS1_k127_9079694_10	35841.BT1A1_0631	3.485e-20	93.0	COG0721@1|root,COG0721@2|Bacteria,1VEK3@1239|Firmicutes,4HNNA@91061|Bacilli,1ZH54@1386|Bacillus	91061|Bacilli	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	-	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Glu-tRNAGln
REGS1_k127_9079694_4	56107.Cylst_3004	9.929e-77	270.0	COG0438@1|root,COG0438@2|Bacteria,1G0YI@1117|Cyanobacteria,1HIQK@1161|Nostocales	1117|Cyanobacteria	M	PFAM Glycosyl transferases group 1	rfaG	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
REGS1_k127_9079694_0	926550.CLDAP_11170	8.754e-187	597.0	COG0154@1|root,COG0154@2|Bacteria,2G5T0@200795|Chloroflexi	200795|Chloroflexi	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
REGS1_k127_9079694_2	926569.ANT_31030	5.146e-88	298.0	COG0052@1|root,COG0052@2|Bacteria,2G5J2@200795|Chloroflexi	200795|Chloroflexi	J	Belongs to the universal ribosomal protein uS2 family	rpsB	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
REGS1_k127_9079694_5	935948.KE386494_gene260	3.067e-72	248.0	COG0264@1|root,COG0264@2|Bacteria,1TPFJ@1239|Firmicutes,248J2@186801|Clostridia,42EMG@68295|Thermoanaerobacterales	186801|Clostridia	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	-	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
REGS1_k127_9079694_3	648996.Theam_0089	1.551e-87	296.0	COG0528@1|root,COG0528@2|Bacteria,2G3IX@200783|Aquificae	200783|Aquificae	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
REGS1_k127_9079694_6	926550.CLDAP_41130	8.633e-64	226.0	COG0233@1|root,COG0233@2|Bacteria,2G6FY@200795|Chloroflexi	200795|Chloroflexi	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	GO:0002181,GO:0002184,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
REGS1_k127_9079694_1	926569.ANT_03500	5.278e-97	323.0	COG0020@1|root,COG0020@2|Bacteria,2G65C@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
REGS1_k127_9079694_7	926569.ANT_03490	5.818e-35	145.0	COG4589@1|root,COG4589@2|Bacteria,2G6QV@200795|Chloroflexi	200795|Chloroflexi	M	Belongs to the CDS family	cdsA	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
REGS1_k127_9079694_8	1128421.JAGA01000003_gene3731	2.241e-34	141.0	COG0642@1|root,COG2205@2|Bacteria	1128421.JAGA01000003_gene3731|-	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_9087277_2	485913.Krac_2926	3.202e-13	76.0	COG2197@1|root,COG3903@1|root,COG2197@2|Bacteria,COG3903@2|Bacteria,2G7W3@200795|Chloroflexi	200795|Chloroflexi	K	transcriptional regulator, LuxR family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22,GerE,NB-ARC,TPR_12
REGS1_k127_9087277_3	649747.HMPREF0083_05690	1.281e-07	62.0	2DPCP@1|root,331IF@2|Bacteria,1VHK6@1239|Firmicutes,4HNK3@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_9087277_1	864069.MicloDRAFT_00046360	4.438e-42	169.0	COG0715@1|root,COG0715@2|Bacteria,1MVZE@1224|Proteobacteria,2TTD4@28211|Alphaproteobacteria,1JTV0@119045|Methylobacteriaceae	28211|Alphaproteobacteria	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
REGS1_k127_9087277_0	485913.Krac_8864	6.349e-45	165.0	COG2521@1|root,COG2521@2|Bacteria,2G7RX@200795|Chloroflexi	200795|Chloroflexi	S	Methyltransferase domain	-	-	-	ko:K06983	-	-	-	-	ko00000	-	-	-	Methyltransf_11
REGS1_k127_9129375_2	649743.HMPREF0972_00151	8.214e-07	53.0	COG0664@1|root,COG0664@2|Bacteria,2GMPN@201174|Actinobacteria,4D359@85005|Actinomycetales	201174|Actinobacteria	K	Crp Fnr family transcriptional regulator	glxR	GO:0000166,GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006109,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010565,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0010675,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030312,GO:0030551,GO:0030552,GO:0030554,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0032993,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043565,GO:0044212,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0062012,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2000874,GO:2001141	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
REGS1_k127_9129375_0	439235.Dalk_1526	4.676e-138	481.0	COG0457@1|root,COG2114@1|root,COG3899@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,42NXT@68525|delta/epsilon subdivisions,2WIZ3@28221|Deltaproteobacteria,2MKIU@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,DZR,Guanylate_cyc,Pkinase,TPR_12
REGS1_k127_9129375_1	1521187.JPIM01000006_gene1717	8.026e-136	439.0	COG4586@1|root,COG4586@2|Bacteria,2G88B@200795|Chloroflexi,376NY@32061|Chloroflexia	32061|Chloroflexia	S	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
REGS1_k127_913725_0	383372.Rcas_0805	4.471e-56	222.0	COG2203@1|root,COG5002@1|root,COG2203@2|Bacteria,COG5002@2|Bacteria,2G7NF@200795|Chloroflexi,374TJ@32061|Chloroflexia	32061|Chloroflexia	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c,HisKA,PAS
REGS1_k127_9145278_4	697281.Mahau_2049	6.572e-05	54.0	2CQ9E@1|root,32SKP@2|Bacteria,1V985@1239|Firmicutes,24TUZ@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_9145278_1	926550.CLDAP_23630	7.177e-48	178.0	COG1595@1|root,COG1595@2|Bacteria,2G6T5@200795|Chloroflexi	200795|Chloroflexi	K	PFAM sigma-70 region 2 domain protein	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
REGS1_k127_9145278_2	1121382.JQKG01000004_gene3980	2.248e-17	91.0	COG3415@1|root,COG3415@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DUF3105,HTH_Tnp_1
REGS1_k127_9145278_0	102232.GLO73106DRAFT_00034110	1.689e-96	325.0	COG4275@1|root,COG4275@2|Bacteria	2|Bacteria	S	Chromate resistance exported protein	chrB	-	-	-	-	-	-	-	-	-	-	-	Chrome_Resist
REGS1_k127_9145278_3	1123073.KB899242_gene950	4.1e-16	82.0	COG2059@1|root,COG2059@2|Bacteria,1MUBW@1224|Proteobacteria,1RPNP@1236|Gammaproteobacteria,1X53Q@135614|Xanthomonadales	135614|Xanthomonadales	P	Chromate transporter	-	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
REGS1_k127_9181058_13	1282876.BAOK01000001_gene1747	7.577e-43	166.0	COG0596@1|root,COG0596@2|Bacteria,1R9X7@1224|Proteobacteria,2TWIW@28211|Alphaproteobacteria,4BTDE@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
REGS1_k127_9181058_0	485913.Krac_9358	3.34e-214	673.0	COG0006@1|root,COG0006@2|Bacteria	2|Bacteria	E	proline dipeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Creatinase_N,Peptidase_M24
REGS1_k127_9181058_2	485913.Krac_9356	7.388e-153	496.0	COG0683@1|root,COG0683@2|Bacteria	2|Bacteria	E	ABC-type branched-chain amino acid transport systems, periplasmic component	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
REGS1_k127_9181058_5	485913.Krac_9355	1.154e-132	428.0	COG0559@1|root,COG0559@2|Bacteria,2G93P@200795|Chloroflexi	200795|Chloroflexi	E	Branched-chain amino acid transport system / permease component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_2
REGS1_k127_9181058_3	485913.Krac_9354	1.372e-137	449.0	COG4177@1|root,COG4177@2|Bacteria,2G8KF@200795|Chloroflexi	200795|Chloroflexi	E	transport system permease	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
REGS1_k127_9181058_6	485913.Krac_9353	9.098e-115	376.0	COG0411@1|root,COG0411@2|Bacteria,2G8SH@200795|Chloroflexi	200795|Chloroflexi	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
REGS1_k127_9181058_7	485913.Krac_9352	6.721e-103	339.0	COG0410@1|root,COG0410@2|Bacteria,2G69M@200795|Chloroflexi	200795|Chloroflexi	E	PFAM ABC transporter related	-	-	-	ko:K11963	ko02010,map02010	M00323	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4.4,3.A.1.4.5	-	-	ABC_tran
REGS1_k127_9181058_4	485913.Krac_9357	1.527e-135	445.0	COG0508@1|root,COG0508@2|Bacteria,2G6A9@200795|Chloroflexi	200795|Chloroflexi	C	Catalytic domain of components of various dehydrogenase complexes	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
REGS1_k127_9181058_10	344747.PM8797T_21028	1.555e-71	265.0	COG1520@1|root,COG1864@1|root,COG2911@1|root,COG2931@1|root,COG3210@1|root,COG3391@1|root,COG4935@1|root,COG5492@1|root,COG1520@2|Bacteria,COG1864@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG3391@2|Bacteria,COG4935@2|Bacteria,COG5492@2|Bacteria,2IY9M@203682|Planctomycetes	203682|Planctomycetes	Q	DNA RNA non-specific endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_9181058_14	153721.MYP_4722	1.785e-41	160.0	COG0662@1|root,COG0662@2|Bacteria,4NV84@976|Bacteroidetes	976|Bacteroidetes	G	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
REGS1_k127_9181058_1	383372.Rcas_3165	1.139e-176	561.0	COG1960@1|root,COG1960@2|Bacteria,2G65J@200795|Chloroflexi,3759Q@32061|Chloroflexia	32061|Chloroflexia	C	PFAM acyl-CoA dehydrogenase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
REGS1_k127_9181058_18	383372.Rcas_0861	6.958e-30	126.0	COG0526@1|root,COG0526@2|Bacteria,2G72F@200795|Chloroflexi,377HE@32061|Chloroflexia	32061|Chloroflexia	CO	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
REGS1_k127_9181058_16	479434.Sthe_1403	2.341e-37	143.0	COG1975@1|root,COG1975@2|Bacteria,2G6Z8@200795|Chloroflexi,27YDJ@189775|Thermomicrobia	189775|Thermomicrobia	O	XdhC and CoxI family	-	-	-	-	-	-	-	-	-	-	-	-	XdhC_CoxI
REGS1_k127_9181058_11	1382306.JNIM01000001_gene2662	8.301e-61	218.0	COG1975@1|root,COG1975@2|Bacteria,2G6H0@200795|Chloroflexi	200795|Chloroflexi	O	XdhC Rossmann domain	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI
REGS1_k127_9181058_17	485913.Krac_10552	1.444e-34	151.0	COG4585@1|root,COG4585@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
REGS1_k127_9181058_12	485913.Krac_6992	2.29e-46	186.0	COG4585@1|root,COG4585@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
REGS1_k127_9181058_9	926554.KI912633_gene3916	1.374e-74	258.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	2.1.1.222,2.1.1.64	ko:K00568	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31
REGS1_k127_9181058_8	324602.Caur_3253	5.076e-100	338.0	COG0438@1|root,COG0438@2|Bacteria,2G61I@200795|Chloroflexi,3753V@32061|Chloroflexia	32061|Chloroflexia	M	PFAM glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
REGS1_k127_9181058_15	324602.Caur_0298	4.252e-41	167.0	COG0823@1|root,COG3210@1|root,COG0823@2|Bacteria,COG3210@2|Bacteria,2G88I@200795|Chloroflexi,3780V@32061|Chloroflexia	32061|Chloroflexia	U	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_9186018_2	1521187.JPIM01000240_gene3267	1.003e-09	63.0	COG0695@1|root,COG0695@2|Bacteria,2G75B@200795|Chloroflexi	200795|Chloroflexi	O	Glutathione S-transferase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Glutaredoxin
REGS1_k127_9186018_1	1206726.BAFV01000112_gene5541	1.014e-75	269.0	COG1578@1|root,COG1578@2|Bacteria,2GNYF@201174|Actinobacteria,4FZEV@85025|Nocardiaceae	201174|Actinobacteria	S	Protein of unknown function DUF89	-	-	-	-	-	-	-	-	-	-	-	-	DUF89
REGS1_k127_9186018_0	765420.OSCT_2638	6.279e-83	284.0	COG2120@1|root,COG2120@2|Bacteria,2G6W3@200795|Chloroflexi,375I3@32061|Chloroflexia	32061|Chloroflexia	S	PFAM LmbE family protein	-	-	3.5.1.115	ko:K18455	-	-	-	-	ko00000,ko01000	-	-	-	PIG-L
REGS1_k127_9208582_0	1123024.AUII01000009_gene1953	2.559e-119	387.0	COG0388@1|root,COG0388@2|Bacteria,2HW1E@201174|Actinobacteria,4EAGX@85010|Pseudonocardiales	201174|Actinobacteria	S	Carbon-nitrogen hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
REGS1_k127_9208582_1	91464.S7335_2049	2.258e-95	316.0	COG1878@1|root,COG1878@2|Bacteria	2|Bacteria	S	arylformamidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
REGS1_k127_9208582_4	262724.TT_P0070	8.099e-57	212.0	COG1030@1|root,COG1030@2|Bacteria,1WKAY@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_9208582_3	1382356.JQMP01000003_gene1477	3.705e-66	230.0	COG2080@1|root,COG2080@2|Bacteria,2GBQV@200795|Chloroflexi,27Y9S@189775|Thermomicrobia	189775|Thermomicrobia	C	[2Fe-2S] binding domain	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
REGS1_k127_9208582_2	479434.Sthe_2308	7.11e-85	289.0	COG1319@1|root,COG1319@2|Bacteria,2G7KW@200795|Chloroflexi,27Z00@189775|Thermomicrobia	189775|Thermomicrobia	C	CO dehydrogenase flavoprotein domain protein	-	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
REGS1_k127_9218482_4	1403313.AXBR01000021_gene3188	9.535e-52	199.0	COG1752@1|root,COG1752@2|Bacteria,1UUVB@1239|Firmicutes,4HDFQ@91061|Bacilli,1ZBCG@1386|Bacillus	91061|Bacilli	S	esterase of the alpha-beta hydrolase superfamily	ylbK	GO:0003674,GO:0003824,GO:0016787	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
REGS1_k127_9218482_2	867845.KI911784_gene2210	7.589e-82	288.0	COG2203@1|root,COG4585@1|root,COG2203@2|Bacteria,COG4585@2|Bacteria,2G88D@200795|Chloroflexi,374V1@32061|Chloroflexia	32061|Chloroflexia	T	histidine kinase, dimerisation and phosphoacceptor region	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GAF_3,HATPase_c,HisKA_3
REGS1_k127_9218482_1	1035308.AQYY01000002_gene479	3.093e-86	298.0	COG0707@1|root,COG0707@2|Bacteria,1UZ4A@1239|Firmicutes,249EE@186801|Clostridia	186801|Clostridia	M	PFAM Monogalactosyldiacylglycerol synthase	-	-	2.4.1.315	ko:K03429	ko00561,ko01100,map00561,map01100	-	R02689,R04377	RC00005,RC00059	ko00000,ko00001,ko01000,ko01003	-	GT28	-	Glyco_tran_28_C,Glyco_trans_1_4,MGDG_synth
REGS1_k127_9218482_3	309801.trd_1859	5.753e-54	207.0	COG0477@1|root,COG2814@2|Bacteria,2G8SG@200795|Chloroflexi,27XS0@189775|Thermomicrobia	189775|Thermomicrobia	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
REGS1_k127_9218482_5	1128421.JAGA01000002_gene1826	1.176e-22	98.0	COG4481@1|root,COG4481@2|Bacteria,2NRSX@2323|unclassified Bacteria	2|Bacteria	S	Bacterial protein of unknown function (DUF951)	yyzM	-	-	-	-	-	-	-	-	-	-	-	DUF951
REGS1_k127_9218482_0	518766.Rmar_1923	8.148e-114	377.0	COG0494@1|root,COG1194@1|root,COG0494@2|Bacteria,COG1194@2|Bacteria,4NDZY@976|Bacteroidetes,1FISB@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	L	NUDIX domain	mutY	-	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD,NUDIX_4
REGS1_k127_936641_1	1380391.JIAS01000017_gene486	1.335e-118	390.0	COG4132@1|root,COG4132@2|Bacteria,1NF20@1224|Proteobacteria,2U0S4@28211|Alphaproteobacteria,2JSH8@204441|Rhodospirillales	204441|Rhodospirillales	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02054	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	BPD_transp_1
REGS1_k127_936641_2	1097668.BYI23_C006370	1.017e-110	363.0	COG1177@1|root,COG1177@2|Bacteria,1MV4A@1224|Proteobacteria,2VMSC@28216|Betaproteobacteria,1K3MI@119060|Burkholderiaceae	28216|Betaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02053	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	BPD_transp_1
REGS1_k127_936641_0	383372.Rcas_1237	1.007e-122	400.0	COG3842@1|root,COG3842@2|Bacteria,2G5JJ@200795|Chloroflexi,37726@32061|Chloroflexia	32061|Chloroflexia	P	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	-	-	-	ko:K02052	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	ABC_tran,TOBE_2
REGS1_k127_94042_0	1121422.AUMW01000011_gene232	1.736e-138	445.0	COG0214@1|root,COG0214@2|Bacteria,1TPSZ@1239|Firmicutes,248C1@186801|Clostridia,25ZYC@186807|Peptococcaceae	186801|Clostridia	H	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively	pdxS	-	4.3.3.6	ko:K06215	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SOR_SNZ
REGS1_k127_94042_2	330214.NIDE0192	2.961e-50	193.0	COG1262@1|root,COG1262@2|Bacteria,3J14J@40117|Nitrospirae	2|Bacteria	S	Evidence 4 Homologs of previously reported genes of	-	-	1.14.99.50	ko:K18912	ko00340,map00340	-	R11013	RC03323,RC03324	ko00000,ko00001,ko01000	-	-	-	FGE-sulfatase,Pkinase
REGS1_k127_94042_4	400682.PAC_15719529	1.518e-06	60.0	KOG2177@1|root,KOG2177@2759|Eukaryota,38X1Z@33154|Opisthokonta,3BJY7@33208|Metazoa	400682.PAC_15719529|-	O	NHL repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_94042_5	1203606.HMPREF1526_03026	0.0002365	53.0	COG2888@1|root,COG2888@2|Bacteria,1UK70@1239|Firmicutes,25FNQ@186801|Clostridia	186801|Clostridia	J	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_94042_3	7739.XP_002587932.1	3.727e-09	68.0	KOG2177@1|root,KOG2177@2759|Eukaryota	7739.XP_002587932.1|-	O	zinc ion binding	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_94042_1	251221.35210810	1.115e-54	212.0	COG5295@1|root,COG5295@2|Bacteria,1GB93@1117|Cyanobacteria	1117|Cyanobacteria	UW	Hep Hag repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_941774_1	696281.Desru_3642	1.454e-63	238.0	COG0728@1|root,COG0728@2|Bacteria,1TPFI@1239|Firmicutes,247N3@186801|Clostridia,2605U@186807|Peptococcaceae	186801|Clostridia	U	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
REGS1_k127_941774_2	926569.ANT_01000	3.155e-59	212.0	COG0164@1|root,COG0164@2|Bacteria,2G6KR@200795|Chloroflexi	200795|Chloroflexi	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
REGS1_k127_941774_3	479434.Sthe_0471	1.714e-41	157.0	COG0335@1|root,COG0335@2|Bacteria,2G6W0@200795|Chloroflexi,27YD2@189775|Thermomicrobia	189775|Thermomicrobia	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site	rplS	-	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
REGS1_k127_941774_4	926550.CLDAP_25850	1.673e-31	129.0	2ERYI@1|root,33JHP@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS1_k127_941774_0	926569.ANT_28060	1.452e-92	310.0	COG0336@1|root,COG0336@2|Bacteria,2G5MY@200795|Chloroflexi	200795|Chloroflexi	J	Belongs to the RNA methyltransferase TrmD family	trmD	GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	tRNA_m1G_MT
REGS1_k127_9803_0	926550.CLDAP_11920	2.091e-43	179.0	COG2132@1|root,COG5617@1|root,COG2132@2|Bacteria,COG5617@2|Bacteria	2|Bacteria	M	Psort location CytoplasmicMembrane, score	-	-	1.16.3.3,1.7.2.1	ko:K00368,ko:K07233,ko:K22349	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000	-	-	-	Cu-oxidase_3,PTPS_related
## 2703 queries scanned
## Total time (seconds): 588.4190490245819
## Rate: 4.59 q/s