## Wed Nov 13 00:38:57 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/4635/R/REGS2_bin.24.fa -m mmseqs --itype genome -o REGS2_bin.24 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/bins_4635/REGS2_bin.24 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
REGS2_k127_1058823_22	1037409.BJ6T_05750	6.078e-07	62.0	2EGCD@1|root,33A46@2|Bacteria,1NW0E@1224|Proteobacteria,2TVBM@28211|Alphaproteobacteria,3JS23@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DUF4339)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4339
REGS2_k127_1058823_8	742818.HMPREF9451_00956	4.511e-71	252.0	COG1420@1|root,COG1420@2|Bacteria,2GKF5@201174|Actinobacteria,4CV7V@84998|Coriobacteriia	84998|Coriobacteriia	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	-	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HTH_DeoR,HrcA
REGS2_k127_1058823_5	479437.Elen_1647	9.485e-105	352.0	COG0484@1|root,COG0484@2|Bacteria,2GK69@201174|Actinobacteria,4CUYQ@84998|Coriobacteriia	84998|Coriobacteriia	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
REGS2_k127_1058823_15	1121866.AUGK01000004_gene121	9.808e-36	150.0	COG1385@1|root,COG1385@2|Bacteria,2GTKX@201174|Actinobacteria,4CUQB@84998|Coriobacteriia	84998|Coriobacteriia	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	-	-	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
REGS2_k127_1058823_6	1232436.CAPF01000016_gene612	3.8e-88	309.0	COG0621@1|root,COG0621@2|Bacteria,2GJEV@201174|Actinobacteria,4CUIJ@84998|Coriobacteriia	84998|Coriobacteriia	J	RNA modification enzyme, MiaB family	yqeV	-	2.8.4.5	ko:K18707	-	-	R10649	RC00003,RC03221	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,UPF0004
REGS2_k127_1058823_3	390989.JOEG01000030_gene1718	2.326e-123	413.0	COG1702@1|root,COG1702@2|Bacteria,2GK0W@201174|Actinobacteria,4DC9N@85008|Micromonosporales	201174|Actinobacteria	T	PhoH-like protein	phoH	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
REGS2_k127_1058823_7	1089553.Tph_c22730	1.511e-72	265.0	COG1480@1|root,COG1480@2|Bacteria,1TR1A@1239|Firmicutes,249W0@186801|Clostridia,42EY4@68295|Thermoanaerobacterales	186801|Clostridia	S	SMART Metal-dependent phosphohydrolase, HD region	-	-	-	ko:K07037	-	-	-	-	ko00000	-	-	-	7TM-7TMR_HD,7TMR-HDED,HD
REGS2_k127_1058823_17	1121866.AUGK01000004_gene127	2.529e-31	128.0	COG0319@1|root,COG0319@2|Bacteria,2GMUF@201174|Actinobacteria,4CVZI@84998|Coriobacteriia	84998|Coriobacteriia	S	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA	ybeY	-	-	ko:K07042	-	-	-	-	ko00000,ko03009	-	-	-	UPF0054
REGS2_k127_1058823_12	293826.Amet_3030	4.922e-51	191.0	COG0671@1|root,COG0818@1|root,COG0671@2|Bacteria,COG0818@2|Bacteria,1VEGR@1239|Firmicutes,248FD@186801|Clostridia,36DSP@31979|Clostridiaceae	186801|Clostridia	IM	Diacylglycerol kinase	dgkA	-	2.7.1.107,2.7.1.66	ko:K00887,ko:K00901	ko00550,ko00561,ko00564,ko01100,ko01110,ko04070,ko04072,ko05231,map00550,map00561,map00564,map01100,map01110,map04070,map04072,map05231	-	R02240,R05626	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	DAGK_prokar,PAP2
REGS2_k127_1058823_10	1101188.KI912155_gene3283	2.267e-56	207.0	COG1253@1|root,COG1253@2|Bacteria,2GIWR@201174|Actinobacteria,1W7VV@1268|Micrococcaceae	201174|Actinobacteria	S	Transporter associated domain	corC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
REGS2_k127_1058823_16	373903.Hore_12520	1.213e-31	128.0	COG0295@1|root,COG0295@2|Bacteria,1V6IP@1239|Firmicutes,24JEM@186801|Clostridia,3WAUA@53433|Halanaerobiales	186801|Clostridia	F	This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis	cdd	-	3.5.4.5	ko:K01489	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01878,R02485,R08221	RC00074,RC00514	ko00000,ko00001,ko01000	-	-	-	dCMP_cyt_deam_1
REGS2_k127_1058823_4	1235794.C811_00628	3.414e-107	356.0	COG1159@1|root,COG1159@2|Bacteria,2GJJE@201174|Actinobacteria,4CUR9@84998|Coriobacteriia	84998|Coriobacteriia	S	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism	era	-	-	ko:K03595	-	-	-	-	ko00000,ko03009,ko03029	-	-	-	KH_2,MMR_HSR1
REGS2_k127_1058823_11	1408254.T458_03605	2.228e-52	198.0	COG0274@1|root,COG0274@2|Bacteria,1TPAJ@1239|Firmicutes,4HAAJ@91061|Bacilli,26QH3@186822|Paenibacillaceae	91061|Bacilli	F	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate	deoC	GO:0003674,GO:0003824,GO:0004139,GO:0005975,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009262,GO:0009264,GO:0009987,GO:0016052,GO:0016829,GO:0016830,GO:0016832,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	4.1.2.4	ko:K01619	ko00030,map00030	-	R01066	RC00436,RC00437	ko00000,ko00001,ko01000	-	-	iSB619.SA_RS00835,iYO844.BSU39420	DeoC
REGS2_k127_1058823_13	479437.Elen_1638	1.795e-47	181.0	COG1381@1|root,COG1381@2|Bacteria,2GK81@201174|Actinobacteria,4CVKT@84998|Coriobacteriia	84998|Coriobacteriia	L	Involved in DNA repair and RecF pathway recombination	recO	-	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
REGS2_k127_1058823_23	1089553.Tph_c25040	4.244e-06	53.0	COG2002@1|root,COG2002@2|Bacteria,1VDBR@1239|Firmicutes,24PKI@186801|Clostridia	186801|Clostridia	K	PFAM SpoVT AbrB	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin
REGS2_k127_1058823_24	1267535.KB906767_gene3817	1.217e-05	53.0	COG5611@1|root,COG5611@2|Bacteria	2|Bacteria	S	PIN domain	vapC	-	-	-	-	-	-	-	-	-	-	-	PIN
REGS2_k127_1058823_2	471855.Shel_11020	5.07e-154	490.0	COG0752@1|root,COG0752@2|Bacteria,2I7YT@201174|Actinobacteria,4CUCS@84998|Coriobacteriia	84998|Coriobacteriia	J	glycyl-tRNA synthetase alpha subunit	glyQ	-	6.1.1.14	ko:K01878	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2e
REGS2_k127_1058823_1	479437.Elen_1385	2.015e-180	600.0	COG0751@1|root,COG0751@2|Bacteria,2HFU4@201174|Actinobacteria,4CUAK@84998|Coriobacteriia	84998|Coriobacteriia	J	Glycyl-tRNA synthetase beta subunit	glyS	-	6.1.1.14	ko:K01879	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_1,tRNA_synt_2f
REGS2_k127_1058823_9	521003.COLINT_02393	1.676e-65	236.0	COG1806@1|root,COG1806@2|Bacteria,2IDD1@201174|Actinobacteria,4CUU9@84998|Coriobacteriia	84998|Coriobacteriia	H	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the	-	-	2.7.11.33,2.7.4.28	ko:K09773	-	-	-	-	ko00000,ko01000	-	-	-	Kinase-PPPase
REGS2_k127_1058823_19	909663.KI867150_gene226	3.706e-24	105.0	COG2336@1|root,COG2336@2|Bacteria	2|Bacteria	T	PFAM SpoVT AbrB	-	-	-	ko:K07172	-	-	-	-	ko00000,ko02048	-	-	-	MazE_antitoxin
REGS2_k127_1058823_14	933262.AXAM01000098_gene3465	9.012e-42	155.0	COG2337@1|root,COG2337@2|Bacteria,1MZJ8@1224|Proteobacteria	1224|Proteobacteria	T	Transcriptional modulator of MazE toxin, MazF	chpA	GO:0001558,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005488,GO:0005515,GO:0005575,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016043,GO:0016070,GO:0016071,GO:0016072,GO:0016075,GO:0016787,GO:0016788,GO:0019222,GO:0019439,GO:0022607,GO:0030308,GO:0032991,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0040008,GO:0042802,GO:0042803,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044877,GO:0045926,GO:0046483,GO:0046700,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051259,GO:0051291,GO:0060255,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575	-	ko:K07171,ko:K18841	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
REGS2_k127_1058823_21	43989.cce_4924	3.924e-09	65.0	COG0864@1|root,COG0864@2|Bacteria,1G9E4@1117|Cyanobacteria	1117|Cyanobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS2_k127_1058823_18	56107.Cylst_1978	6.746e-30	124.0	COG2337@1|root,COG2337@2|Bacteria,1G7P3@1117|Cyanobacteria,1HPNZ@1161|Nostocales	1117|Cyanobacteria	L	Toxic component of a toxin-antitoxin (TA) module	-	-	-	ko:K07171	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
REGS2_k127_1058823_20	1246448.ANAZ01000052_gene1990	1.656e-09	63.0	COG2161@1|root,COG2161@2|Bacteria,2GV08@201174|Actinobacteria,4EQGZ@85012|Streptosporangiales	201174|Actinobacteria	D	Antitoxin Phd_YefM, type II toxin-antitoxin system	relB	GO:0003674,GO:0005488,GO:0005515,GO:0008150,GO:0040008,GO:0045927,GO:0048518,GO:0050789,GO:0065007,GO:0097351	-	ko:K19159	-	-	-	-	ko00000,ko02048	-	-	-	PhdYeFM_antitox
REGS2_k127_1058823_0	471855.Shel_11050	0.0	1140.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2GK73@201174|Actinobacteria,4CUB1@84998|Coriobacteriia	84998|Coriobacteriia	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
REGS2_k127_1081694_18	1123250.KB908390_gene102	3.368e-66	231.0	COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,4H2JC@909932|Negativicutes	909932|Negativicutes	IQ	reductase	fabG	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
REGS2_k127_1081694_27	1051632.TPY_1218	2.353e-25	109.0	COG0236@1|root,COG0236@2|Bacteria,1VEE3@1239|Firmicutes,24QME@186801|Clostridia,3WCPE@538999|Clostridiales incertae sedis	186801|Clostridia	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
REGS2_k127_1081694_9	138119.DSY2658	1.369e-104	350.0	COG2070@1|root,COG2070@2|Bacteria,1TPX1@1239|Firmicutes,247YZ@186801|Clostridia,2600J@186807|Peptococcaceae	186801|Clostridia	S	PFAM 2-nitropropane dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	NMO
REGS2_k127_1081694_3	1048834.TC41_1274	2.531e-142	472.0	COG0304@1|root,COG0304@2|Bacteria,1TPA7@1239|Firmicutes,4H9SD@91061|Bacilli,2786J@186823|Alicyclobacillaceae	91061|Bacilli	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	-	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
REGS2_k127_1081694_20	338966.Ppro_1778	3.528e-49	184.0	COG0571@1|root,COG0571@2|Bacteria,1MUQ6@1224|Proteobacteria,42MIP@68525|delta/epsilon subdivisions,2WNDB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	rnc	GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
REGS2_k127_1081694_0	1232436.CAPF01000014_gene637	6.095e-284	913.0	COG1196@1|root,COG1196@2|Bacteria,2GK93@201174|Actinobacteria,4CUK9@84998|Coriobacteriia	84998|Coriobacteriia	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
REGS2_k127_1081694_8	479437.Elen_1371	1.777e-107	363.0	COG0552@1|root,COG0552@2|Bacteria,2GJQH@201174|Actinobacteria,4CU9Q@84998|Coriobacteriia	84998|Coriobacteriia	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
REGS2_k127_1081694_31	292459.STH2445	8.021e-18	98.0	COG0681@1|root,COG0681@2|Bacteria,1V7H9@1239|Firmicutes,24MVR@186801|Clostridia	186801|Clostridia	U	Belongs to the peptidase S26 family	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
REGS2_k127_1081694_2	867903.ThesuDRAFT_00298	2.437e-159	515.0	COG0541@1|root,COG0541@2|Bacteria,1TP06@1239|Firmicutes,248EU@186801|Clostridia,3WCDI@538999|Clostridiales incertae sedis	186801|Clostridia	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
REGS2_k127_1081694_26	1111121.HMPREF1247_1188	5.582e-29	127.0	COG0228@1|root,COG0228@2|Bacteria,2IKU0@201174|Actinobacteria,4CWB2@84998|Coriobacteriia	84998|Coriobacteriia	J	Belongs to the bacterial ribosomal protein bS16 family	rpsP	-	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
REGS2_k127_1081694_32	867903.ThesuDRAFT_00296	4.418e-16	81.0	COG1837@1|root,COG1837@2|Bacteria,1VEG7@1239|Firmicutes,24QKN@186801|Clostridia,3WDJD@538999|Clostridiales incertae sedis	186801|Clostridia	S	Belongs to the UPF0109 family	ylqC	-	-	ko:K06960	-	-	-	-	ko00000	-	-	-	KH_4
REGS2_k127_1081694_30	445975.COLSTE_01536	1.188e-20	100.0	COG0806@1|root,COG0806@2|Bacteria,2HV43@201174|Actinobacteria,4CW9R@84998|Coriobacteriia	84998|Coriobacteriia	J	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes	rimM	-	-	ko:K02860	-	-	-	-	ko00000,ko03009	-	-	-	RimM
REGS2_k127_1081694_13	717605.Theco_2126	3.035e-81	277.0	COG0336@1|root,COG0336@2|Bacteria,1TPBV@1239|Firmicutes,4HBFV@91061|Bacilli,26RCU@186822|Paenibacillaceae	91061|Bacilli	J	Belongs to the RNA methyltransferase TrmD family	trmD	GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	tRNA_m1G_MT
REGS2_k127_1081694_23	742818.HMPREF9451_00615	9.521e-45	170.0	COG0681@1|root,COG0681@2|Bacteria,2GIYN@201174|Actinobacteria,4CVY4@84998|Coriobacteriia	84998|Coriobacteriia	U	Belongs to the peptidase S26 family	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S26
REGS2_k127_1081694_24	1034345.CAEM01000019_gene1661	5.537e-44	162.0	COG0335@1|root,COG0335@2|Bacteria,2IHRT@201174|Actinobacteria,4CVXA@84998|Coriobacteriia	84998|Coriobacteriia	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site	rplS	-	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
REGS2_k127_1081694_22	266117.Rxyl_0250	3.883e-47	184.0	COG0681@1|root,COG0681@2|Bacteria,2GIYN@201174|Actinobacteria,4CQK4@84995|Rubrobacteria	84995|Rubrobacteria	U	Belongs to the peptidase S26 family	-	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
REGS2_k127_1081694_21	1382315.JPOI01000001_gene3001	2.819e-47	181.0	COG0164@1|root,COG0164@2|Bacteria,1V1D6@1239|Firmicutes,4HB7M@91061|Bacilli,1WF7A@129337|Geobacillus	91061|Bacilli	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
REGS2_k127_1081694_28	1236902.ANAS01000008_gene2351	2.611e-25	110.0	COG0792@1|root,COG0792@2|Bacteria,2IQ3X@201174|Actinobacteria,4EJZV@85012|Streptosporangiales	201174|Actinobacteria	L	Uncharacterised protein family UPF0102	yraN	-	-	ko:K07460	-	-	-	-	ko00000	-	-	-	UPF0102
REGS2_k127_1081694_5	1384484.AEQU_0897	3.893e-123	411.0	COG0606@1|root,COG0606@2|Bacteria,2GJIQ@201174|Actinobacteria,4CUV5@84998|Coriobacteriia	84998|Coriobacteriia	O	Mg chelatase-like protein	-	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
REGS2_k127_1081694_16	553184.ATORI0001_0509	6.944e-69	252.0	COG0758@1|root,COG0758@2|Bacteria,2GKDA@201174|Actinobacteria,4CVBV@84998|Coriobacteriia	84998|Coriobacteriia	LU	DNA protecting protein DprA	-	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
REGS2_k127_1081694_1	521003.COLINT_02465	1.057e-159	516.0	COG1206@1|root,COG1206@2|Bacteria,2H3AD@201174|Actinobacteria,4CUI9@84998|Coriobacteriia	84998|Coriobacteriia	J	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs	trmFO	-	2.1.1.74	ko:K04094	-	-	-	-	ko00000,ko01000,ko03016,ko03036	-	-	-	GIDA
REGS2_k127_1081694_15	553184.ATORI0001_0507	6.002e-76	274.0	COG4974@1|root,COG4974@2|Bacteria,2GNDP@201174|Actinobacteria,4CUM8@84998|Coriobacteriia	84998|Coriobacteriia	D	Belongs to the 'phage' integrase family. XerC subfamily	-	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
REGS2_k127_1081694_10	1306174.JODP01000016_gene7134	3.206e-97	324.0	COG1191@1|root,COG1191@2|Bacteria,2GKBK@201174|Actinobacteria	201174|Actinobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	whiG	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_r2,Sigma70_r3,Sigma70_r4
REGS2_k127_1081694_29	1114856.C496_08791	5.11e-21	100.0	COG0745@1|root,arCOG02595@2157|Archaea,2XZSB@28890|Euryarchaeota,23XQF@183963|Halobacteria	183963|Halobacteria	T	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
REGS2_k127_1081694_11	1209989.TepiRe1_1365	2.591e-90	308.0	COG0052@1|root,COG0052@2|Bacteria,1TPNA@1239|Firmicutes,247ZR@186801|Clostridia,42ENB@68295|Thermoanaerobacterales	186801|Clostridia	J	Belongs to the universal ribosomal protein uS2 family	rpsB	-	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
REGS2_k127_1081694_14	573061.Clocel_1775	8.675e-78	271.0	COG0264@1|root,COG0264@2|Bacteria,1TPFJ@1239|Firmicutes,248J2@186801|Clostridia,36DEJ@31979|Clostridiaceae	186801|Clostridia	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	-	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
REGS2_k127_1081694_7	502558.EGYY_06700	5.596e-108	357.0	COG0528@1|root,COG0528@2|Bacteria,2GKWQ@201174|Actinobacteria,4CUD7@84998|Coriobacteriia	84998|Coriobacteriia	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
REGS2_k127_1081694_17	1169144.KB910924_gene386	2.377e-66	230.0	COG0233@1|root,COG0233@2|Bacteria,1V1F2@1239|Firmicutes,4HFSH@91061|Bacilli,1ZAZF@1386|Bacillus	91061|Bacilli	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	GO:0002181,GO:0002184,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
REGS2_k127_1081694_12	429009.Adeg_0583	3.654e-82	280.0	COG0020@1|root,COG0020@2|Bacteria,1TQTS@1239|Firmicutes,247TE@186801|Clostridia,42F7X@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
REGS2_k127_1081694_25	1203602.HMPREF1527_00394	3.525e-42	171.0	COG4589@1|root,COG4589@2|Bacteria,2GNWK@201174|Actinobacteria,4CV43@84998|Coriobacteriia	84998|Coriobacteriia	S	Cytidylyltransferase family	cdsA	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
REGS2_k127_1081694_4	471855.Shel_23580	1.713e-126	435.0	COG0743@1|root,COG0743@2|Bacteria,2GIRV@201174|Actinobacteria,4CUA4@84998|Coriobacteriia	84998|Coriobacteriia	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	-	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	-	DXPR_C,DXP_redisom_C,DXP_reductoisom
REGS2_k127_1081694_19	661087.HMPREF1008_01411	1.098e-60	226.0	COG0750@1|root,COG0750@2|Bacteria,2HUFX@201174|Actinobacteria,4CUH9@84998|Coriobacteriia	84998|Coriobacteriia	M	RIP metalloprotease RseP	-	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_M50
REGS2_k127_1081694_6	522772.Dacet_0872	5.555e-116	384.0	COG0821@1|root,COG0821@2|Bacteria,2GF8V@200930|Deferribacteres	200930|Deferribacteres	H	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	-	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
REGS2_k127_122691_17	502025.Hoch_1497	4.978e-20	102.0	COG1524@1|root,COG1524@2|Bacteria,1MYH0@1224|Proteobacteria,42QJN@68525|delta/epsilon subdivisions,2WXWZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
REGS2_k127_122691_8	502558.EGYY_12970	1.896e-49	184.0	COG1011@1|root,COG1011@2|Bacteria	2|Bacteria	S	phosphatase activity	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2,Hydrolase,Hydrolase_like
REGS2_k127_122691_16	1230342.CTM_06501	4.419e-23	106.0	COG0778@1|root,COG0778@2|Bacteria,1V8BZ@1239|Firmicutes,25B4H@186801|Clostridia,36W9B@31979|Clostridiaceae	186801|Clostridia	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
REGS2_k127_122691_19	644966.Tmar_1675	2.34e-13	83.0	COG0707@1|root,COG0707@2|Bacteria,1UQ6A@1239|Firmicutes,248FR@186801|Clostridia,3WDAC@538999|Clostridiales incertae sedis	186801|Clostridia	M	Monogalactosyldiacylglycerol (MGDG) synthase	ugtP	-	2.4.1.315	ko:K03429	ko00561,ko01100,map00561,map01100	-	R02689,R04377	RC00005,RC00059	ko00000,ko00001,ko01000,ko01003	-	GT28	-	Glyco_tran_28_C,Glycos_transf_1,MGDG_synth
REGS2_k127_122691_15	521095.Apar_0915	1.59e-25	117.0	COG1366@1|root,COG2172@1|root,COG1366@2|Bacteria,COG2172@2|Bacteria,2HUNT@201174|Actinobacteria,4CV8A@84998|Coriobacteriia	84998|Coriobacteriia	T	Belongs to the anti-sigma-factor antagonist family	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c_2,STAS,STAS_2
REGS2_k127_122691_10	33876.JNXY01000015_gene7454	2.398e-46	193.0	COG2208@1|root,COG2208@2|Bacteria,2GKN8@201174|Actinobacteria,4DAEE@85008|Micromonosporales	201174|Actinobacteria	T	Stage II sporulation	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,SpoIIE
REGS2_k127_122691_22	641147.HMPREF9021_01431	1.616e-06	62.0	COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,2VIDI@28216|Betaproteobacteria,2KQ6W@206351|Neisseriales	206351|Neisseriales	T	Psort location CytoplasmicMembrane, score 10.00	atoS	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_8
REGS2_k127_122691_11	666684.AfiDRAFT_0025	8.034e-44	173.0	COG0785@1|root,COG0785@2|Bacteria,1RCP7@1224|Proteobacteria,2TSAI@28211|Alphaproteobacteria,3JS7I@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	cytochrome c biogenesis protein	MA20_17170	-	-	ko:K06196	-	-	-	-	ko00000,ko02000	5.A.1.2	-	-	DsbD
REGS2_k127_122691_0	1449126.JQKL01000002_gene1616	9.427e-222	718.0	COG2217@1|root,COG2217@2|Bacteria,1TP5S@1239|Firmicutes,247MW@186801|Clostridia,267PD@186813|unclassified Clostridiales	186801|Clostridia	P	Heavy-metal-associated domain	copA	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
REGS2_k127_122691_21	208439.AJAP_38260	1.858e-09	61.0	COG2608@1|root,COG2608@2|Bacteria,2GT2C@201174|Actinobacteria,4ECWZ@85010|Pseudonocardiales	201174|Actinobacteria	P	Heavy-metal-associated domain	-	-	-	-	-	-	-	-	-	-	-	-	HMA
REGS2_k127_122691_13	1195236.CTER_0329	3.041e-43	172.0	COG2608@1|root,COG2836@1|root,COG4633@1|root,COG2608@2|Bacteria,COG2836@2|Bacteria,COG4633@2|Bacteria,1TQ02@1239|Firmicutes,249HC@186801|Clostridia,3WNAJ@541000|Ruminococcaceae	186801|Clostridia	P	Cytochrome C biogenesis protein transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1,DsbD_2,HMA
REGS2_k127_122691_1	1121468.AUBR01000072_gene1024	1.304e-134	442.0	COG2204@1|root,COG2204@2|Bacteria,1VSKG@1239|Firmicutes,24ZP4@186801|Clostridia,42J66@68295|Thermoanaerobacterales	186801|Clostridia	T	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	ko:K02481	-	-	-	-	ko00000,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
REGS2_k127_122691_5	293826.Amet_3256	6.729e-83	295.0	COG3852@1|root,COG3852@2|Bacteria,1TRH0@1239|Firmicutes,25F1F@186801|Clostridia,36HP9@31979|Clostridiaceae	186801|Clostridia	T	PFAM ATP-binding region, ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
REGS2_k127_122691_4	243231.GSU1887	1.925e-84	302.0	COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,42M3C@68525|delta/epsilon subdivisions,2WJ21@28221|Deltaproteobacteria,43UH4@69541|Desulfuromonadales	28221|Deltaproteobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	rpoN	-	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
REGS2_k127_122691_9	760568.Desku_1900	3.27e-47	182.0	COG0697@1|root,COG0697@2|Bacteria,1TR6G@1239|Firmicutes,24AMC@186801|Clostridia,262QM@186807|Peptococcaceae	186801|Clostridia	EG	PFAM EamA-like transporter family	yicL	-	-	-	-	-	-	-	-	-	-	-	EamA
REGS2_k127_122691_20	926692.AZYG01000063_gene1193	1.664e-12	72.0	COG1937@1|root,COG1937@2|Bacteria,1VEF5@1239|Firmicutes,24QRR@186801|Clostridia,3WASA@53433|Halanaerobiales	186801|Clostridia	S	PFAM Uncharacterised BCR, COG1937	csoR	-	-	ko:K21600	-	-	-	-	ko00000,ko03000	-	-	-	Trns_repr_metal
REGS2_k127_122691_18	768706.Desor_5062	7.998e-16	85.0	COG3439@1|root,COG3439@2|Bacteria,1VA5R@1239|Firmicutes,24NQI@186801|Clostridia	186801|Clostridia	S	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	DUF302
REGS2_k127_122691_14	867903.ThesuDRAFT_00009	1.375e-30	123.0	COG3118@1|root,COG3118@2|Bacteria,1VA3Y@1239|Firmicutes,24MM5@186801|Clostridia,3WCN3@538999|Clostridiales incertae sedis	186801|Clostridia	O	Thioredoxin	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
REGS2_k127_122691_23	575540.Isop_1221	3.312e-05	56.0	COG0276@1|root,COG0276@2|Bacteria,2IX75@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the ferrous insertion into protoporphyrin IX	hemH	GO:0003674,GO:0003824,GO:0004325,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	Ferrochelatase
REGS2_k127_122691_12	324602.Caur_3001	2.759e-43	167.0	COG0613@1|root,COG0613@2|Bacteria,2G74N@200795|Chloroflexi,37789@32061|Chloroflexia	32061|Chloroflexia	S	SMART phosphoesterase PHP domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PHP,PHP_C
REGS2_k127_122691_3	304371.MCP_2273	1.913e-84	293.0	arCOG00787@1|root,arCOG00787@2157|Archaea	2157|Archaea	L	UvrD REP helicase	-	-	3.6.4.12	ko:K03657,ko:K07465	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
REGS2_k127_122691_2	1125863.JAFN01000001_gene1594	7.409e-129	424.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,42MKR@68525|delta/epsilon subdivisions,2WJ0U@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	PFAM aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
REGS2_k127_122691_7	643648.Slip_1093	1.987e-54	208.0	COG1032@1|root,COG1032@2|Bacteria,1TPGT@1239|Firmicutes,247JS@186801|Clostridia,42KFC@68298|Syntrophomonadaceae	186801|Clostridia	C	Protein of unknown function (DUF4080)	-	-	1.21.98.3	ko:K04034	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R06268,R06269,R06270	RC00741,RC01491,RC01492	ko00000,ko00001,ko01000	-	-	-	B12-binding,DUF4080,Radical_SAM
REGS2_k127_122691_24	1179773.BN6_65050	6.954e-05	55.0	COG0535@1|root,COG0535@2|Bacteria,2GNSY@201174|Actinobacteria,4E6Q9@85010|Pseudonocardiales	201174|Actinobacteria	C	4Fe-4S single cluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM,SPASM
REGS2_k127_122691_6	635013.TherJR_2108	1.423e-78	276.0	COG0438@1|root,COG0438@2|Bacteria,1TPY6@1239|Firmicutes,24834@186801|Clostridia,261PX@186807|Peptococcaceae	186801|Clostridia	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
REGS2_k127_1246596_4	471855.Shel_19490	3.027e-92	308.0	COG1190@1|root,COG1190@2|Bacteria,2GKE0@201174|Actinobacteria,4CUAX@84998|Coriobacteriia	84998|Coriobacteriia	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon,tRNA_bind
REGS2_k127_1246596_0	1504319.GM45_4015	0.0	1116.0	COG0542@1|root,COG0542@2|Bacteria,2GJ77@201174|Actinobacteria,3UWDQ@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	O	C-terminal, D2-small domain, of ClpB protein	clpC	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006457,GO:0008150,GO:0009987,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030312,GO:0040007,GO:0042802,GO:0042803,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046983,GO:0071944	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
REGS2_k127_1246596_2	1120973.AQXL01000112_gene1045	2.096e-126	424.0	COG1066@1|root,COG1066@2|Bacteria,1TQ7Y@1239|Firmicutes,4H9YC@91061|Bacilli,2786D@186823|Alicyclobacillaceae	91061|Bacilli	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	AAA_25,ATPase,ChlI
REGS2_k127_1246596_3	635013.TherJR_0249	6.504e-99	335.0	COG1623@1|root,COG1623@2|Bacteria,1TQD8@1239|Firmicutes,247J4@186801|Clostridia,25ZYJ@186807|Peptococcaceae	186801|Clostridia	L	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation	disA	-	2.7.7.85	ko:K07067	-	-	-	-	ko00000,ko01000	-	-	-	DisA-linker,DisA_N,HHH,HHH_2
REGS2_k127_1246596_6	313612.L8106_17332	1.381e-74	264.0	COG4956@1|root,COG4956@2|Bacteria,1FZYF@1117|Cyanobacteria,1H7EU@1150|Oscillatoriales	1117|Cyanobacteria	S	Integral membrane protein (Pin domain superfamily)	ycf81	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	PIN_4,TRAM
REGS2_k127_1246596_10	479437.Elen_2235	1.557e-53	198.0	COG1211@1|root,COG1211@2|Bacteria,2GNHP@201174|Actinobacteria,4CV1H@84998|Coriobacteriia	84998|Coriobacteriia	I	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)	ispD	-	2.7.7.60	ko:K00991	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD
REGS2_k127_1246596_9	521095.Apar_1183	1.347e-60	213.0	COG0245@1|root,COG0245@2|Bacteria,2II8H@201174|Actinobacteria,4CW0D@84998|Coriobacteriia	84998|Coriobacteriia	H	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)	ispF	-	4.6.1.12	ko:K01770	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	YgbB
REGS2_k127_1246596_5	401526.TcarDRAFT_0124	8.61e-76	266.0	COG1045@1|root,COG1045@2|Bacteria,1TR42@1239|Firmicutes,4H2RG@909932|Negativicutes	909932|Negativicutes	E	serine O-acetyltransferase	cysE	-	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,SATase_N
REGS2_k127_1246596_1	1120973.AQXL01000112_gene1053	1.745e-150	497.0	COG0215@1|root,COG0215@2|Bacteria,1TP9D@1239|Firmicutes,4HA6D@91061|Bacilli,2780M@186823|Alicyclobacillaceae	91061|Bacilli	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	GO:0000166,GO:0001871,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009986,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030246,GO:0030247,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2001065	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e,tRNA-synt_1g
REGS2_k127_1246596_7	471855.Shel_19440	2.802e-67	240.0	COG0566@1|root,COG0566@2|Bacteria,2GJMR@201174|Actinobacteria,4CV66@84998|Coriobacteriia	84998|Coriobacteriia	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	-	-	2.1.1.185	ko:K03218	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SpoU_methylase,SpoU_sub_bind
REGS2_k127_1246596_11	700015.Corgl_1376	1.012e-22	104.0	COG3688@1|root,COG3688@2|Bacteria,2HUV5@201174|Actinobacteria,4CVRA@84998|Coriobacteriia	84998|Coriobacteriia	S	YacP-like NYN domain	-	-	-	ko:K06962	-	-	-	-	ko00000	-	-	-	NYN_YacP
REGS2_k127_1246596_8	264732.Moth_2479	2.381e-63	225.0	COG1595@1|root,COG1595@2|Bacteria,1TP55@1239|Firmicutes,249VX@186801|Clostridia,42ETZ@68295|Thermoanaerobacterales	186801|Clostridia	K	PFAM sigma-70 region 2 domain protein	sigH	-	-	ko:K03091	-	-	-	-	ko00000,ko03021	-	-	-	GerE,Sigma70_r2,Sigma70_r4_2
REGS2_k127_1246596_12	502025.Hoch_3346	3.239e-13	78.0	COG1262@1|root,COG2114@1|root,COG5635@1|root,COG1262@2|Bacteria,COG2114@2|Bacteria,COG5635@2|Bacteria,1R66C@1224|Proteobacteria	1224|Proteobacteria	T	NACHT domain	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,NACHT
REGS2_k127_1351705_1	1449126.JQKL01000034_gene1279	7.674e-177	566.0	COG1541@1|root,COG1541@2|Bacteria,1TQA1@1239|Firmicutes,248G9@186801|Clostridia,26A76@186813|unclassified Clostridiales	186801|Clostridia	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	paaK	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
REGS2_k127_1351705_11	555088.DealDRAFT_2600	1.997e-33	145.0	COG4747@1|root,COG4747@2|Bacteria,1V7U2@1239|Firmicutes,24JE5@186801|Clostridia,42JZR@68298|Syntrophomonadaceae	186801|Clostridia	S	ACT domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ACT
REGS2_k127_1351705_14	215803.DB30_4312	3.392e-06	58.0	COG2199@1|root,COG3706@2|Bacteria,1Q90F@1224|Proteobacteria,4393E@68525|delta/epsilon subdivisions,2X49A@28221|Deltaproteobacteria,2YYJ6@29|Myxococcales	28221|Deltaproteobacteria	T	Diguanylate cyclase, GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Response_reg
REGS2_k127_1351705_15	1122216.AUHW01000033_gene425	0.0007364	48.0	COG4968@1|root,COG4968@2|Bacteria,1VD7G@1239|Firmicutes,4H9IM@909932|Negativicutes	909932|Negativicutes	NU	Prokaryotic N-terminal methylation motif	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl
REGS2_k127_1351705_5	203119.Cthe_3179	2.127e-69	252.0	COG1686@1|root,COG1686@2|Bacteria,1TQ8M@1239|Firmicutes,2480S@186801|Clostridia,3WGET@541000|Ruminococcaceae	186801|Clostridia	M	Belongs to the peptidase S11 family	dacB2	-	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	PBP5_C,Peptidase_S11
REGS2_k127_1351705_3	861299.J421_3957	3.201e-88	306.0	COG0404@1|root,COG0404@2|Bacteria,1ZTBZ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	The glycine cleavage system catalyzes the degradation of glycine	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
REGS2_k127_1351705_7	1121017.AUFG01000005_gene986	8.29e-46	177.0	COG0509@1|root,COG0509@2|Bacteria,2IKN2@201174|Actinobacteria,4FGP8@85021|Intrasporangiaceae	201174|Actinobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	iNJ661.Rv1826	GCV_H
REGS2_k127_1351705_2	1304875.JAFZ01000001_gene1189	7.402e-130	429.0	COG0403@1|root,COG0403@2|Bacteria,3T9WE@508458|Synergistetes	508458|Synergistetes	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPA	-	1.4.4.2	ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
REGS2_k127_1351705_0	1121430.JMLG01000028_gene1456	4.706e-178	572.0	COG1003@1|root,COG1003@2|Bacteria,1TPK9@1239|Firmicutes,2480Q@186801|Clostridia,260E1@186807|Peptococcaceae	186801|Clostridia	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPB	-	1.4.4.2	ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	Aminotran_5,GDC-P
REGS2_k127_1351705_10	885272.JonanDRAFT_0927	5.568e-38	158.0	COG0095@1|root,COG0095@2|Bacteria,3TBDG@508458|Synergistetes	508458|Synergistetes	H	PFAM Biotin lipoate A B protein ligase family	-	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
REGS2_k127_1351705_13	1283299.AUKG01000002_gene4958	1.107e-13	79.0	2AUU1@1|root,31KH5@2|Bacteria,2HPC3@201174|Actinobacteria,4CQQ6@84995|Rubrobacteria	84995|Rubrobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS2_k127_1351705_12	1463825.JNXC01000023_gene4906	7.146e-31	127.0	COG1716@1|root,COG1716@2|Bacteria,2GK99@201174|Actinobacteria,4E2ZJ@85010|Pseudonocardiales	201174|Actinobacteria	T	(FHA) domain	garA	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0006109,GO:0006110,GO:0006140,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009894,GO:0009895,GO:0009987,GO:0010563,GO:0010675,GO:0010677,GO:0016020,GO:0016310,GO:0019219,GO:0019220,GO:0019222,GO:0019538,GO:0030312,GO:0030808,GO:0030809,GO:0030811,GO:0030812,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031329,GO:0031330,GO:0036211,GO:0042325,GO:0042326,GO:0042802,GO:0043170,GO:0043412,GO:0043457,GO:0043467,GO:0043470,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0045820,GO:0045912,GO:0045934,GO:0045936,GO:0045980,GO:0046777,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051174,GO:0051193,GO:0051195,GO:0051196,GO:0051198,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:1900371,GO:1900372,GO:1900542,GO:1900543,GO:1901564,GO:1903578,GO:1903579,GO:2001169,GO:2001170	-	-	-	-	-	-	-	-	-	-	FHA,Yop-YscD_cpl
REGS2_k127_1351705_8	661087.HMPREF1008_01454	7.788e-40	162.0	COG0789@1|root,COG0789@2|Bacteria,2HBV6@201174|Actinobacteria,4CVXV@84998|Coriobacteriia	84998|Coriobacteriia	K	helix_turn_helix, mercury resistance	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
REGS2_k127_1351705_9	234267.Acid_0127	1.27e-38	150.0	COG1102@1|root,COG1102@2|Bacteria	2|Bacteria	F	Psort location Cytoplasmic, score	-	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Cytidylate_kin2,GAF_2,Pribosyltran
REGS2_k127_1351705_6	1380390.JIAT01000011_gene2837	1.788e-50	184.0	COG0634@1|root,COG0634@2|Bacteria,2GMDZ@201174|Actinobacteria,4CPVX@84995|Rubrobacteria	84995|Rubrobacteria	F	Belongs to the purine pyrimidine phosphoribosyltransferase family	-	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
REGS2_k127_1351705_4	338963.Pcar_3127	1.744e-69	245.0	COG1226@1|root,COG1226@2|Bacteria,1MU1R@1224|Proteobacteria,42MW6@68525|delta/epsilon subdivisions,2WIYU@28221|Deltaproteobacteria,43UJB@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	Ion channel	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans_2,TrkA_C,TrkA_N
REGS2_k127_1455695_7	1121441.AUCX01000007_gene1087	1.681e-42	177.0	COG0697@1|root,COG0697@2|Bacteria,1PX5W@1224|Proteobacteria,42MGR@68525|delta/epsilon subdivisions,2WJSI@28221|Deltaproteobacteria,2M9Y0@213115|Desulfovibrionales	28221|Deltaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
REGS2_k127_1455695_0	871968.DESME_04480	2.888e-147	479.0	COG0015@1|root,COG0015@2|Bacteria,1TPMM@1239|Firmicutes,2485N@186801|Clostridia,260RX@186807|Peptococcaceae	186801|Clostridia	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	purB	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
REGS2_k127_1455695_5	1307759.JOMJ01000003_gene2096	2.854e-52	205.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,42M0W@68525|delta/epsilon subdivisions,2WIK8@28221|Deltaproteobacteria,2M8CQ@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	Diguanylate cyclase phosphodiesterase with PAS PAC sensor(S)	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,HAMP,PAS,PAS_4,PAS_9,Response_reg,dCache_2
REGS2_k127_1455695_8	1123400.KB904766_gene2962	1.037e-09	72.0	290RU@1|root,2ZNDZ@2|Bacteria,1P98B@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS2_k127_1455695_2	644966.Tmar_0214	1.317e-104	360.0	COG0421@1|root,COG0421@2|Bacteria,1UI4A@1239|Firmicutes,25GIE@186801|Clostridia	186801|Clostridia	E	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	-	-	-	-	-	-	-	-	-	-	-	-	Spermine_synth
REGS2_k127_1455695_3	1125863.JAFN01000001_gene420	8.912e-93	325.0	COG2871@1|root,COG3894@1|root,COG2871@2|Bacteria,COG3894@2|Bacteria,1MV6C@1224|Proteobacteria,42MF5@68525|delta/epsilon subdivisions,2WKPR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Domain of unknown function (DUF4445)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
REGS2_k127_1455695_1	1121866.AUGK01000003_gene1319	1.516e-118	390.0	COG0152@1|root,COG0152@2|Bacteria,2GK3H@201174|Actinobacteria,4CUV7@84998|Coriobacteriia	84998|Coriobacteriia	F	SAICAR synthetase	purC	-	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
REGS2_k127_1455695_4	861299.J421_3375	8.609e-61	220.0	COG0688@1|root,COG0688@2|Bacteria,1ZU9Z@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer)	psd	-	4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PS_Dcarbxylase
REGS2_k127_1455695_6	379066.GAU_1734	3.914e-48	184.0	COG1183@1|root,COG1183@2|Bacteria,1ZTJP@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	CDP-alcohol phosphatidyltransferase	-	-	2.7.8.8	ko:K17103	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	M00093	R01800	RC00002,RC00017,RC02795	ko00000,ko00001,ko00002,ko01000	-	-	-	CDP-OH_P_transf
REGS2_k127_1531905_9	1121952.ATXT01000013_gene2159	3.877e-94	315.0	COG1028@1|root,COG1028@2|Bacteria,2GM6W@201174|Actinobacteria,4FMUD@85023|Microbacteriaceae	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
REGS2_k127_1531905_16	445975.COLSTE_01888	3.688e-12	78.0	COG0797@1|root,COG0797@2|Bacteria,2GSPY@201174|Actinobacteria,4CUPI@84998|Coriobacteriia	84998|Coriobacteriia	M	Psort location Extracellular, score 9.55	-	-	-	-	-	-	-	-	-	-	-	-	DPBB_1
REGS2_k127_1531905_5	742722.HMPREF9463_01943	1.681e-147	474.0	COG4608@1|root,COG4608@2|Bacteria,2H4BW@201174|Actinobacteria,4CUUN@84998|Coriobacteriia	84998|Coriobacteriia	P	ABC transporter, ATP-binding protein	-	-	-	ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
REGS2_k127_1531905_2	700015.Corgl_1247	1.285e-156	499.0	COG0444@1|root,COG0444@2|Bacteria,2GIXV@201174|Actinobacteria,4CUH7@84998|Coriobacteriia	84998|Coriobacteriia	P	ABC transporter, ATP-binding protein	-	-	-	ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
REGS2_k127_1531905_12	269799.Gmet_1236	7.006e-70	250.0	COG1173@1|root,COG1173@2|Bacteria,1MU26@1224|Proteobacteria,42MFP@68525|delta/epsilon subdivisions,2WJ47@28221|Deltaproteobacteria,43TPC@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	N-terminal TM domain of oligopeptide transport permease C	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
REGS2_k127_1531905_8	742742.HMPREF9452_00045	1.058e-101	344.0	COG0601@1|root,COG0601@2|Bacteria,2GJ2C@201174|Actinobacteria,4CUGS@84998|Coriobacteriia	84998|Coriobacteriia	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
REGS2_k127_1531905_4	1118060.CAGZ01000025_gene959	2.683e-149	492.0	COG4166@1|root,COG4166@2|Bacteria,2GIUH@201174|Actinobacteria,4CUJQ@84998|Coriobacteriia	84998|Coriobacteriia	E	pathway, signal sequence	-	-	-	ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	SBP_bac_5
REGS2_k127_1531905_15	649764.HMPREF0762_00144	9.499e-13	70.0	COG1314@1|root,COG1314@2|Bacteria,2HTTU@201174|Actinobacteria,4CW9B@84998|Coriobacteriia	84998|Coriobacteriia	U	Preprotein translocase SecG subunit	secG	-	-	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecG
REGS2_k127_1531905_1	663278.Ethha_1549	6.745e-179	577.0	COG0696@1|root,COG0696@2|Bacteria,1TPM4@1239|Firmicutes,247JG@186801|Clostridia,3WGBI@541000|Ruminococcaceae	186801|Clostridia	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmI	-	5.4.2.12	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,Phosphodiest,iPGM_N
REGS2_k127_1531905_11	502558.EGYY_12920	5.257e-81	277.0	COG0149@1|root,COG0149@2|Bacteria,2GJXZ@201174|Actinobacteria,4CU8V@84998|Coriobacteriia	84998|Coriobacteriia	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	-	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
REGS2_k127_1531905_6	479437.Elen_1778	1.164e-143	478.0	COG0126@1|root,COG0126@2|Bacteria,2GJC6@201174|Actinobacteria,4CUGT@84998|Coriobacteriia	84998|Coriobacteriia	F	Belongs to the phosphoglycerate kinase family	pgk	-	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
REGS2_k127_1531905_3	479437.Elen_1779	7.282e-152	488.0	COG0057@1|root,COG0057@2|Bacteria,2GJK4@201174|Actinobacteria,4CUJP@84998|Coriobacteriia	84998|Coriobacteriia	C	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	gap	-	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
REGS2_k127_1531905_7	1034345.CAEM01000019_gene1817	6.899e-112	376.0	COG1481@1|root,COG1481@2|Bacteria,2GJZU@201174|Actinobacteria,4CUY0@84998|Coriobacteriia	84998|Coriobacteriia	K	May be required for sporulation	whiA	-	-	ko:K09762	-	-	-	-	ko00000	-	-	-	HTH_WhiA,LAGLIDADG_WhiA,WhiA_N
REGS2_k127_1531905_13	264732.Moth_0259	2.357e-67	252.0	COG0391@1|root,COG0391@2|Bacteria,1TPNV@1239|Firmicutes,248G0@186801|Clostridia,42EVZ@68295|Thermoanaerobacterales	186801|Clostridia	S	Required for morphogenesis under gluconeogenic growth conditions	-	-	-	-	-	-	-	-	-	-	-	-	UPF0052
REGS2_k127_1531905_10	479437.Elen_1783	1.145e-91	318.0	COG1660@1|root,COG1660@2|Bacteria,2GMWB@201174|Actinobacteria,4CUJK@84998|Coriobacteriia	84998|Coriobacteriia	S	Displays ATPase and GTPase activities	-	-	-	ko:K06958	-	-	-	-	ko00000,ko03019	-	-	-	ATP_bind_2
REGS2_k127_1531905_14	1161401.ASJA01000021_gene651	1.015e-13	76.0	COG1950@1|root,COG1950@2|Bacteria,1N1DF@1224|Proteobacteria,2UDEK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	PFAM Membrane protein of	-	-	-	ko:K08972	-	-	-	-	ko00000	-	-	-	Phage_holin_4_2
REGS2_k127_1531905_17	58123.JOFJ01000007_gene586	6.045e-12	80.0	COG3087@1|root,COG3087@2|Bacteria,2GNX9@201174|Actinobacteria,4EIUA@85012|Streptosporangiales	201174|Actinobacteria	D	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS2_k127_1531905_0	1232436.CAPF01000005_gene1834	4.477e-221	706.0	COG0322@1|root,COG0322@2|Bacteria,2GIS4@201174|Actinobacteria,4CUKR@84998|Coriobacteriia	84998|Coriobacteriia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
REGS2_k127_1774685_9	649764.HMPREF0762_00237	8.178e-34	131.0	COG1418@1|root,COG1418@2|Bacteria,2I9DW@201174|Actinobacteria,4CURU@84998|Coriobacteriia	84998|Coriobacteriia	NU	Endoribonuclease that initiates mRNA decay	rny	-	-	ko:K18682	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DUF3552,HD,KH_1
REGS2_k127_1774685_2	479437.Elen_1617	1.087e-171	548.0	COG1418@1|root,COG3170@1|root,COG1418@2|Bacteria,COG3170@2|Bacteria,2I9DW@201174|Actinobacteria,4CURU@84998|Coriobacteriia	84998|Coriobacteriia	NU	Endoribonuclease that initiates mRNA decay	rny	-	-	ko:K18682	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DUF3552,HD,KH_1
REGS2_k127_1774685_13	1121365.AQXB01000001_gene874	2.271e-09	69.0	COG2137@1|root,COG2137@2|Bacteria,2GMRF@201174|Actinobacteria,22MP4@1653|Corynebacteriaceae	201174|Actinobacteria	S	Modulates RecA activity	recX	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03565	-	-	-	-	ko00000,ko03400	-	-	-	RecX
REGS2_k127_1774685_3	1121866.AUGK01000004_gene143	2.457e-159	509.0	COG0468@1|root,COG0468@2|Bacteria,2GJ4P@201174|Actinobacteria,4CUYM@84998|Coriobacteriia	84998|Coriobacteriia	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	-	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
REGS2_k127_1774685_12	448385.sce5087	3.161e-12	77.0	COG1514@1|root,COG1514@2|Bacteria,1RDB2@1224|Proteobacteria,42TMM@68525|delta/epsilon subdivisions,2WQ6S@28221|Deltaproteobacteria,2YVZ3@29|Myxococcales	28221|Deltaproteobacteria	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	-	-	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
REGS2_k127_1774685_5	2423.NA23_0210095	1.183e-68	256.0	COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,2GBWX@200918|Thermotogae	200918|Thermotogae	S	competence damage-inducible protein CinA	-	-	3.5.1.42	ko:K03742	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA,MoCF_biosynth
REGS2_k127_1774685_7	649764.HMPREF0762_00240	2.02e-51	188.0	COG0558@1|root,COG1546@1|root,COG0558@2|Bacteria,COG1546@2|Bacteria,2IQ8T@201174|Actinobacteria,4CYG4@84998|Coriobacteriia	84998|Coriobacteriia	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	cinA	-	-	-	-	-	-	-	-	-	-	-	CDP-OH_P_transf,CinA
REGS2_k127_1774685_4	471855.Shel_10700	3.16e-111	374.0	COG0621@1|root,COG0621@2|Bacteria,2GKRI@201174|Actinobacteria,4CU9J@84998|Coriobacteriia	84998|Coriobacteriia	H	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12	rimO	-	2.8.4.4	ko:K14441	-	-	R10652	RC00003,RC03217	ko00000,ko01000,ko03009	-	-	-	Radical_SAM,TRAM,UPF0004
REGS2_k127_1774685_6	479437.Elen_1622	8.244e-62	216.0	COG1666@1|root,COG1666@2|Bacteria,2IFIU@201174|Actinobacteria,4CUXA@84998|Coriobacteriia	84998|Coriobacteriia	S	Belongs to the UPF0234 family	-	-	-	ko:K09767	-	-	-	-	ko00000	-	-	-	DUF520
REGS2_k127_1774685_11	1123250.KB908379_gene1203	6.645e-16	88.0	COG1426@1|root,COG1426@2|Bacteria,1V9EA@1239|Firmicutes,4H958@909932|Negativicutes	909932|Negativicutes	S	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4115,HTH_25
REGS2_k127_1774685_1	502558.EGYY_14180	9.269e-191	622.0	COG1674@1|root,COG1674@2|Bacteria,2GK3T@201174|Actinobacteria,4CU9F@84998|Coriobacteriia	84998|Coriobacteriia	D	FtsK SpoIIIE family	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
REGS2_k127_1774685_8	643648.Slip_1037	2.238e-44	171.0	COG1968@1|root,COG1968@2|Bacteria,1TPFA@1239|Firmicutes,249KK@186801|Clostridia,42JXF@68298|Syntrophomonadaceae	186801|Clostridia	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
REGS2_k127_1774685_0	1321773.HMPREF9069_01923	8.788e-204	648.0	COG0595@1|root,COG0595@2|Bacteria,2GIW7@201174|Actinobacteria,4CUDR@84998|Coriobacteriia	84998|Coriobacteriia	J	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay	rnj	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,Lactamase_B_2,RMMBL
REGS2_k127_1774685_10	292459.STH1549	9.335e-21	94.0	COG0329@1|root,COG0329@2|Bacteria,1TPCK@1239|Firmicutes,247T5@186801|Clostridia	186801|Clostridia	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
REGS2_k127_1849630_1	1384484.AEQU_1028	2.345e-60	233.0	COG2720@1|root,COG2720@2|Bacteria,2GISH@201174|Actinobacteria,4CV4M@84998|Coriobacteriia	84998|Coriobacteriia	V	G5	-	-	-	-	-	-	-	-	-	-	-	-	G5,PG_binding_4,VanW
REGS2_k127_1849630_0	561175.KB894096_gene498	3.133e-230	739.0	COG1109@1|root,COG1208@1|root,COG1109@2|Bacteria,COG1208@2|Bacteria,2GKTE@201174|Actinobacteria,4EFSZ@85012|Streptosporangiales	201174|Actinobacteria	GJM	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III	-	-	2.7.7.13,5.4.2.8	ko:K16881	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114,M00362	R00885,R01818	RC00002,RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase,PGM_PMM_I,PGM_PMM_II,PGM_PMM_III
REGS2_k127_1849630_3	521003.COLINT_02423	8.333e-33	146.0	COG0558@1|root,COG0558@2|Bacteria,2GM3F@201174|Actinobacteria,4CVSC@84998|Coriobacteriia	84998|Coriobacteriia	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.41	ko:K08744	ko00564,ko01100,map00564,map01100	-	R02030	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
REGS2_k127_1849630_2	1121428.DESHY_70081___1	9.369e-56	207.0	COG0598@1|root,COG0598@2|Bacteria,1TPSV@1239|Firmicutes,24DE3@186801|Clostridia,262H7@186807|Peptococcaceae	186801|Clostridia	P	Mediates influx of magnesium ions	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
REGS2_k127_1849630_4	1120949.KB903294_gene4503	1.237e-10	68.0	COG3237@1|root,COG3237@2|Bacteria,2GQQ4@201174|Actinobacteria,4DFT3@85008|Micromonosporales	201174|Actinobacteria	S	Belongs to the UPF0337 (CsbD) family	-	-	-	-	-	-	-	-	-	-	-	-	CsbD
REGS2_k127_2043212_7	742742.HMPREF9452_01213	1.119e-93	318.0	COG2252@1|root,COG2252@2|Bacteria,2GKYD@201174|Actinobacteria,4CUN6@84998|Coriobacteriia	84998|Coriobacteriia	S	permease	-	-	-	ko:K06901	-	-	-	-	ko00000,ko02000	2.A.1.40	-	-	Xan_ur_permease
REGS2_k127_2043212_15	1122611.KB903958_gene4061	2.935e-14	81.0	COG1051@1|root,COG1051@2|Bacteria,2I1PY@201174|Actinobacteria,4EP5A@85012|Streptosporangiales	201174|Actinobacteria	F	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
REGS2_k127_2043212_11	1232436.CAPF01000014_gene769	3.258e-58	205.0	COG0756@1|root,COG0756@2|Bacteria,2IHYY@201174|Actinobacteria,4CVRY@84998|Coriobacteriia	84998|Coriobacteriia	F	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA	dut	-	3.6.1.23	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00053	R02100,R11896	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	dUTPase
REGS2_k127_2043212_13	1232410.KI421428_gene1013	1.443e-43	168.0	COG1180@1|root,COG1180@2|Bacteria,1NQC1@1224|Proteobacteria,42QX3@68525|delta/epsilon subdivisions,2WPC7@28221|Deltaproteobacteria,43SFR@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	4Fe-4S single cluster domain	pflA	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
REGS2_k127_2043212_16	693661.Arcve_0324	9.512e-06	55.0	COG0526@1|root,arCOG01972@2157|Archaea	2157|Archaea	O	Thioredoxin	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	DUF836,Thioredoxin,Thioredoxin_3
REGS2_k127_2043212_0	1125863.JAFN01000001_gene1365	9.017e-260	824.0	COG1328@1|root,COG1328@2|Bacteria,1MWMS@1224|Proteobacteria,42M8V@68525|delta/epsilon subdivisions,2WJ7S@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	TIGRFAM anaerobic ribonucleoside-triphosphate reductase	-	-	1.1.98.6	ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R11633,R11634,R11635,R11636	RC00613	ko00000,ko00001,ko00002,ko01000	-	-	-	NRDD
REGS2_k127_2043212_12	661087.HMPREF1008_01462	9.163e-55	196.0	COG1327@1|root,COG1327@2|Bacteria,2IHU9@201174|Actinobacteria,4CVYF@84998|Coriobacteriia	84998|Coriobacteriia	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	-	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
REGS2_k127_2043212_17	1255043.TVNIR_2726	0.0005322	49.0	COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,1RMFZ@1236|Gammaproteobacteria,1WXD7@135613|Chromatiales	135613|Chromatiales	M	lytic transglycosylase	-	-	-	ko:K08307	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	LysM,SLT
REGS2_k127_2043212_9	768706.Desor_3195	6.291e-75	257.0	COG1974@1|root,COG1974@2|Bacteria,1TQ3H@1239|Firmicutes,24AXJ@186801|Clostridia,2612Y@186807|Peptococcaceae	186801|Clostridia	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	-	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
REGS2_k127_2043212_2	479437.Elen_1612	1.084e-147	479.0	COG2262@1|root,COG2262@2|Bacteria,2GK55@201174|Actinobacteria,4CUJD@84998|Coriobacteriia	84998|Coriobacteriia	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
REGS2_k127_2043212_3	477974.Daud_1603	2.411e-140	457.0	COG0436@1|root,COG0436@2|Bacteria,1TQD6@1239|Firmicutes,2491B@186801|Clostridia,260IS@186807|Peptococcaceae	186801|Clostridia	E	PFAM Aminotransferase class I and II	dapL	-	2.6.1.83	ko:K10206	ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230	M00527	R07613	RC00006,RC01847	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
REGS2_k127_2043212_8	717605.Theco_2192	2.078e-79	274.0	COG0253@1|root,COG0253@2|Bacteria,1TPMN@1239|Firmicutes,4HBH4@91061|Bacilli,26QWK@186822|Paenibacillaceae	91061|Bacilli	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
REGS2_k127_2043212_6	1232436.CAPF01000014_gene775	8.995e-94	317.0	COG0324@1|root,COG0324@2|Bacteria,2GKFT@201174|Actinobacteria,4CV6N@84998|Coriobacteriia	84998|Coriobacteriia	F	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	-	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
REGS2_k127_2043212_4	635013.TherJR_0336	2.492e-113	383.0	COG2078@1|root,COG3885@1|root,COG2078@2|Bacteria,COG3885@2|Bacteria,1TQH8@1239|Firmicutes,2491Q@186801|Clostridia,26152@186807|Peptococcaceae	186801|Clostridia	S	pfam ammecr1	-	-	-	ko:K06990,ko:K09141	-	-	-	-	ko00000,ko04812	-	-	-	AMMECR1,LigB
REGS2_k127_2043212_1	479437.Elen_1614	1.203e-161	531.0	COG0621@1|root,COG0621@2|Bacteria,2GJEV@201174|Actinobacteria,4CUYE@84998|Coriobacteriia	84998|Coriobacteriia	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
REGS2_k127_2043212_10	1089553.Tph_c11640	8.903e-62	222.0	COG0613@1|root,COG0613@2|Bacteria,1TPI5@1239|Firmicutes,248H2@186801|Clostridia,42GGH@68295|Thermoanaerobacterales	186801|Clostridia	S	SMART phosphoesterase PHP domain protein	-	-	3.1.3.97	ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	PHP
REGS2_k127_2043212_14	767817.Desgi_1886	2.065e-37	143.0	COG2359@1|root,COG2359@2|Bacteria,1V6G8@1239|Firmicutes,24MXY@186801|Clostridia,26255@186807|Peptococcaceae	186801|Clostridia	S	PFAM Stage V sporulation protein S	spoVS	-	-	ko:K06416	-	-	-	-	ko00000	-	-	-	SpoVS
REGS2_k127_2043212_5	1118060.CAGZ01000024_gene562	3.545e-107	361.0	COG0323@1|root,COG0323@2|Bacteria,2H8CS@201174|Actinobacteria,4CUJV@84998|Coriobacteriia	84998|Coriobacteriia	L	histidine kinase DNA gyrase B	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HATPase_c_3
REGS2_k127_2111925_19	1114970.PSF113_1512	6.937e-23	102.0	COG2832@1|root,COG2832@2|Bacteria,1N7BI@1224|Proteobacteria,1S9V2@1236|Gammaproteobacteria,1YQQA@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	S	membrane	-	-	-	ko:K09790	-	-	-	-	ko00000	-	-	-	DUF454
REGS2_k127_2111925_20	351160.RCIX2198	9.271e-20	104.0	COG4354@1|root,arCOG03865@2157|Archaea	2157|Archaea	G	intracellular protein transport	-	-	3.2.1.40	ko:K05989	-	-	-	-	ko00000,ko01000	-	-	-	Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N
REGS2_k127_2111925_1	1282876.BAOK01000001_gene967	4.737e-159	511.0	COG3367@1|root,COG3367@2|Bacteria,1MVEX@1224|Proteobacteria,2TTKH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Domain of unknown function (DUF1611_N) Rossmann-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF1611,DUF1611_N
REGS2_k127_2111925_5	1242864.D187_006746	4.177e-88	299.0	COG1028@1|root,COG1028@2|Bacteria,1R413@1224|Proteobacteria,42S6B@68525|delta/epsilon subdivisions,2WNKV@28221|Deltaproteobacteria,2YXNN@29|Myxococcales	28221|Deltaproteobacteria	IQ	short-chain dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
REGS2_k127_2111925_17	1121382.JQKG01000001_gene2290	1.61e-25	117.0	COG2120@1|root,COG2120@2|Bacteria	2|Bacteria	S	N-acetylglucosaminylinositol deacetylase activity	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
REGS2_k127_2111925_2	744872.Spica_0890	1.4e-152	502.0	COG1063@1|root,COG1063@2|Bacteria,2J5R7@203691|Spirochaetes	203691|Spirochaetes	C	PFAM Alcohol dehydrogenase GroES-like	-	-	1.1.1.103,1.1.1.14,1.1.1.303,1.1.1.4	ko:K00004,ko:K00008,ko:K00060	ko00040,ko00051,ko00260,ko00650,ko01100,map00040,map00051,map00260,map00650,map01100	M00014	R00875,R01465,R01896,R02855,R02946,R10504	RC00085,RC00102,RC00205,RC00525	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
REGS2_k127_2111925_0	1313301.AUGC01000008_gene386	3.619e-161	527.0	COG0156@1|root,COG0156@2|Bacteria,4NFBU@976|Bacteroidetes	976|Bacteroidetes	E	Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA	kbl	-	2.3.1.29	ko:K00639	ko00260,map00260	-	R00371	RC00004,RC00394	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
REGS2_k127_2111925_22	1349820.M707_12950	1.899e-15	88.0	2ERRQ@1|root,33JAW@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS2_k127_2111925_15	1121106.JQKB01000012_gene4682	2.325e-32	140.0	COG0265@1|root,COG0823@1|root,COG2931@1|root,COG0265@2|Bacteria,COG0823@2|Bacteria,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	ko:K08372	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	HemolysinCabind,NACHT,PDZ_2,Trypsin_2,VCBS
REGS2_k127_2111925_10	994573.T472_0215410	5.153e-52	199.0	COG0860@1|root,COG0860@2|Bacteria,1UY5Q@1239|Firmicutes,247Y6@186801|Clostridia,36HS7@31979|Clostridiaceae	186801|Clostridia	M	N-acetylmuramoyl-L-alanine amidase	lytC_3	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_3,SH3_3
REGS2_k127_2111925_18	398578.Daci_5718	2.789e-24	119.0	COG0265@1|root,COG0265@2|Bacteria,1R61I@1224|Proteobacteria,2VP90@28216|Betaproteobacteria,4ACQ1@80864|Comamonadaceae	28216|Betaproteobacteria	O	peptidase S1 and S6, chymotrypsin Hap	-	-	3.4.21.50	ko:K01337	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Trypsin
REGS2_k127_2111925_8	700598.Niako_5053	3.122e-66	249.0	COG4447@1|root,COG4447@2|Bacteria,4NRP7@976|Bacteroidetes,1IU78@117747|Sphingobacteriia	976|Bacteroidetes	UW	protein related to plant photosystem II stability assembly factor	-	-	-	-	-	-	-	-	-	-	-	-	PSII_BNR
REGS2_k127_2111925_24	1038859.AXAU01000015_gene1014	2.353e-07	59.0	COG5397@1|root,COG5397@2|Bacteria,1PJM3@1224|Proteobacteria,2U1M6@28211|Alphaproteobacteria,3JXFR@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Nucleotidyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1488,NTP_transf_8
REGS2_k127_2111925_21	246197.MXAN_0726	3.376e-18	92.0	COG0745@1|root,COG0745@2|Bacteria	246197.MXAN_0726|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS2_k127_2111925_9	56780.SYN_00775	3.51e-65	231.0	COG2197@1|root,COG2197@2|Bacteria,1RARA@1224|Proteobacteria,43B1G@68525|delta/epsilon subdivisions,2X5U5@28221|Deltaproteobacteria,2MRK4@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
REGS2_k127_2111925_23	1464048.JNZS01000001_gene281	5.142e-09	67.0	COG4585@1|root,COG4585@2|Bacteria,2HDZV@201174|Actinobacteria,4DH44@85008|Micromonosporales	201174|Actinobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K07675	ko02020,map02020	M00473	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA_3
REGS2_k127_2111925_3	861299.J421_0161	2.437e-127	433.0	COG0643@1|root,COG0643@2|Bacteria,1ZTCI@142182|Gemmatimonadetes	142182|Gemmatimonadetes	NT	Signal transducing histidine kinase, homodimeric domain	-	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt
REGS2_k127_2111925_11	1265505.ATUG01000001_gene3161	2.475e-45	173.0	COG0835@1|root,COG0835@2|Bacteria,1RD1W@1224|Proteobacteria,43AFQ@68525|delta/epsilon subdivisions,2X5VI@28221|Deltaproteobacteria,2MJRP@213118|Desulfobacterales	28221|Deltaproteobacteria	NT	Two component signalling adaptor domain	-	-	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
REGS2_k127_2111925_7	1304885.AUEY01000048_gene621	2.742e-73	267.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,42N03@68525|delta/epsilon subdivisions,2WIX4@28221|Deltaproteobacteria,2MINP@213118|Desulfobacterales	28221|Deltaproteobacteria	NT	PFAM chemotaxis sensory transducer	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,HBM,MCPsignal,dCache_1
REGS2_k127_2111925_6	485915.Dret_0661	8.988e-84	286.0	COG1352@1|root,COG1352@2|Bacteria,1MU6W@1224|Proteobacteria,42MR2@68525|delta/epsilon subdivisions,2WKKH@28221|Deltaproteobacteria,2M8R1@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP	-	-	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheR,CheR_N,Response_reg
REGS2_k127_2111925_13	589865.DaAHT2_1684	1.161e-37	149.0	COG1871@1|root,COG1871@2|Bacteria,1RAWA@1224|Proteobacteria,42QP1@68525|delta/epsilon subdivisions,2WQBY@28221|Deltaproteobacteria,2MJPU@213118|Desulfobacterales	28221|Deltaproteobacteria	NT	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis	cheD1	-	3.5.1.44	ko:K03411	ko02030,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheD
REGS2_k127_2111925_14	933262.AXAM01000005_gene2486	2.029e-34	143.0	COG0745@1|root,COG0745@2|Bacteria,1N6UF@1224|Proteobacteria,42V8J@68525|delta/epsilon subdivisions,2X863@28221|Deltaproteobacteria,2MPP4@213118|Desulfobacterales	28221|Deltaproteobacteria	KT	cheY-homologous receiver domain	-	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
REGS2_k127_2111925_4	589865.DaAHT2_1680	5.404e-125	412.0	COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,42M27@68525|delta/epsilon subdivisions,2WJ2S@28221|Deltaproteobacteria,2MHVY@213118|Desulfobacterales	28221|Deltaproteobacteria	NT	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	cheB	-	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,Response_reg
REGS2_k127_2111925_16	1229205.BUPH_06103	1.17e-26	123.0	COG2202@1|root,COG4192@1|root,COG4585@1|root,COG2202@2|Bacteria,COG4192@2|Bacteria,COG4585@2|Bacteria,1MWPN@1224|Proteobacteria,2VM3J@28216|Betaproteobacteria,1KHSA@119060|Burkholderiaceae	28216|Betaproteobacteria	T	histidine kinase, dimerisation and phosphoacceptor region	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA_3,PAS_4,PAS_8,PAS_9
REGS2_k127_2111925_12	477974.Daud_2111	5.704e-39	153.0	COG2253@1|root,COG2253@2|Bacteria,1UKDE@1239|Firmicutes,25FUI@186801|Clostridia,267DM@186807|Peptococcaceae	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	AbiEii
REGS2_k127_2256571_19	1121866.AUGK01000012_gene1776	2.457e-64	232.0	COG1461@1|root,COG1461@2|Bacteria,2GKII@201174|Actinobacteria,4CUVH@84998|Coriobacteriia	84998|Coriobacteriia	S	DAK2 domain fusion protein YloV	-	-	-	ko:K07030	-	-	-	-	ko00000	-	-	-	Dak1_2,Dak2
REGS2_k127_2256571_30	1034345.CAEM01000023_gene801	1.504e-35	138.0	COG1302@1|root,COG1302@2|Bacteria,2HUZ1@201174|Actinobacteria,4CW16@84998|Coriobacteriia	84998|Coriobacteriia	S	Asp23 family, cell envelope-related function	-	-	-	-	-	-	-	-	-	-	-	-	Asp23
REGS2_k127_2256571_45	1123288.SOV_4c06340	3.359e-06	57.0	2EKB5@1|root,33E1I@2|Bacteria,1VFSV@1239|Firmicutes,4H8IH@909932|Negativicutes	909932|Negativicutes	S	Domain of unknown function (DUF1858)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1858
REGS2_k127_2256571_37	1118060.CAGZ01000024_gene715	8.866e-24	103.0	COG0227@1|root,COG0227@2|Bacteria,2GQNU@201174|Actinobacteria,4CWH3@84998|Coriobacteriia	84998|Coriobacteriia	J	Belongs to the bacterial ribosomal protein bL28 family	rpmB	-	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
REGS2_k127_2256571_25	370438.PTH_1596	5.363e-51	202.0	COG2203@1|root,COG2206@1|root,COG2203@2|Bacteria,COG2206@2|Bacteria,1UZN2@1239|Firmicutes,248SE@186801|Clostridia,261QQ@186807|Peptococcaceae	186801|Clostridia	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HD
REGS2_k127_2256571_39	887929.HMP0721_2081	3.12e-17	95.0	COG1564@1|root,COG1564@2|Bacteria,1VA0W@1239|Firmicutes,24NG6@186801|Clostridia,25WFR@186806|Eubacteriaceae	186801|Clostridia	H	thiamine pyrophosphokinase	thiN	-	2.7.6.2	ko:K00949	ko00730,ko01100,map00730,map01100	-	R00619	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	TPK_B1_binding,TPK_catalytic
REGS2_k127_2256571_32	42256.RradSPS_2437	8.785e-34	139.0	COG3859@1|root,COG3859@2|Bacteria	2|Bacteria	S	thiamine transport	thiT	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K16789	-	-	-	-	ko00000,ko02000	2.A.88.3	-	-	Thia_YuaJ
REGS2_k127_2256571_34	1313172.YM304_31100	2.228e-31	139.0	COG0739@1|root,COG0739@2|Bacteria	2|Bacteria	M	heme binding	-	-	-	ko:K21471,ko:K21472	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	LysM,Peptidase_M23
REGS2_k127_2256571_40	1487956.DR71_1087	1.516e-13	83.0	COG0515@1|root,COG0515@2|Bacteria,2GJ1J@201174|Actinobacteria,22JIY@1653|Corynebacteriaceae	201174|Actinobacteria	KLT	serine threonine protein kinase	pknB	GO:0000270,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008047,GO:0008150,GO:0008152,GO:0008360,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009605,GO:0009607,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0010698,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0022603,GO:0022604,GO:0030145,GO:0030203,GO:0030234,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032091,GO:0034645,GO:0036211,GO:0040007,GO:0042304,GO:0042546,GO:0042802,GO:0043085,GO:0043086,GO:0043167,GO:0043169,GO:0043170,GO:0043207,GO:0043388,GO:0043393,GO:0043412,GO:0044036,GO:0044038,GO:0044085,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046872,GO:0046890,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050896,GO:0051055,GO:0051098,GO:0051099,GO:0051100,GO:0051101,GO:0051128,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0062012,GO:0062014,GO:0065007,GO:0065008,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0075136,GO:0080090,GO:0098772,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
REGS2_k127_2256571_41	1111131.HMPREF1255_0239	8.516e-12	78.0	COG2331@1|root,COG2331@2|Bacteria,2IQHE@201174|Actinobacteria	201174|Actinobacteria	S	Regulatory protein, FmdB family	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
REGS2_k127_2256571_10	401526.TcarDRAFT_0978	3.92e-112	371.0	COG1494@1|root,COG1494@2|Bacteria,1TP0D@1239|Firmicutes,4H22D@909932|Negativicutes	909932|Negativicutes	G	fructose-1,6-bisphosphatase	glpX	-	3.1.3.11	ko:K02446	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00165,M00167	R00762,R04780	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_glpX
REGS2_k127_2256571_13	1384484.AEQU_1120	7.361e-79	282.0	COG0144@1|root,COG0781@1|root,COG0144@2|Bacteria,COG0781@2|Bacteria,2GM21@201174|Actinobacteria,4CVCM@84998|Coriobacteriia	84998|Coriobacteriia	JK	Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family	-	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,NusB
REGS2_k127_2256571_21	1452718.JBOY01000001_gene496	6.828e-59	215.0	COG0223@1|root,COG0223@2|Bacteria,1MU4Q@1224|Proteobacteria,1RP1T@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	GO:0003674,GO:0003824,GO:0004479,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006418,GO:0006431,GO:0006464,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019752,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	iECABU_c1320.ECABU_c37050,iECUMN_1333.ECUMN_3761,ic_1306.c4048	Formyl_trans_C,Formyl_trans_N
REGS2_k127_2256571_31	266117.Rxyl_1468	2.29e-35	143.0	COG0242@1|root,COG0242@2|Bacteria,2GJ87@201174|Actinobacteria,4CQ1V@84995|Rubrobacteria	84995|Rubrobacteria	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
REGS2_k127_2256571_6	1430331.EP10_01290	3.177e-169	561.0	COG1198@1|root,COG1198@2|Bacteria,1TNYB@1239|Firmicutes,4H9WW@91061|Bacilli,1WEMW@129337|Geobacillus	91061|Bacilli	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
REGS2_k127_2256571_3	469378.Ccur_08430	1.111e-187	596.0	COG0192@1|root,COG0192@2|Bacteria,2GJ4U@201174|Actinobacteria,4CU9D@84998|Coriobacteriia	84998|Coriobacteriia	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
REGS2_k127_2256571_46	1238425.J07HQW2_02696	2.368e-05	54.0	COG3431@1|root,arCOG06422@2157|Archaea,2XZNV@28890|Euryarchaeota,23X3C@183963|Halobacteria	183963|Halobacteria	S	Phosphate-starvation-inducible E	-	-	-	-	-	-	-	-	-	-	-	-	PsiE
REGS2_k127_2256571_35	1121028.ARQE01000012_gene412	1.552e-30	135.0	COG0265@1|root,COG0265@2|Bacteria	2|Bacteria	O	serine-type endopeptidase activity	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	Beta_helix,CBM_6,DUF1565,PDZ_2,Trypsin_2
REGS2_k127_2256571_44	593907.Celgi_0019	2.36e-06	59.0	COG5297@1|root,COG5297@2|Bacteria,2IAE1@201174|Actinobacteria	201174|Actinobacteria	G	type 3a cellulose-binding domain protein	-	-	3.2.1.11,3.2.1.4	ko:K01179,ko:K05988	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308,R11309	-	ko00000,ko00001,ko01000	-	GH5,GH66,GH9	-	CBM_2,CBM_3,Glyco_hydro_9,fn3
REGS2_k127_2256571_5	649764.HMPREF0762_00103	2.064e-171	560.0	COG0008@1|root,COG0008@2|Bacteria,2GJJS@201174|Actinobacteria,4CV46@84998|Coriobacteriia	84998|Coriobacteriia	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
REGS2_k127_2256571_0	1187851.A33M_2297	1.536e-268	839.0	COG0008@1|root,COG0008@2|Bacteria,1MUC8@1224|Proteobacteria,2TRKX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Glutaminyl-tRNA synthetase	glnS	-	6.1.1.18	ko:K01886	ko00970,ko01100,map00970,map01100	M00359,M00360	R03652	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
REGS2_k127_2256571_42	74547.PMT_2851	2.064e-09	63.0	2DSJE@1|root,33GEB@2|Bacteria,1GB2T@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS2_k127_2256571_4	593750.Metfor_0883	2.362e-175	577.0	COG1239@1|root,COG1240@1|root,arCOG00438@2157|Archaea,arCOG06472@2157|Archaea,2XUP4@28890|Euryarchaeota,2N9BN@224756|Methanomicrobia	224756|Methanomicrobia	H	AAA domain (dynein-related subfamily)	-	-	6.6.1.1	ko:K03404,ko:K03405	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03877	RC01012	ko00000,ko00001,ko01000	-	-	-	AAA_5,Mg_chelatase,VWA_2
REGS2_k127_2256571_16	471853.Bcav_1900	4.863e-72	266.0	COG0322@1|root,COG2176@1|root,COG0322@2|Bacteria,COG2176@2|Bacteria,2GMC0@201174|Actinobacteria	201174|Actinobacteria	L	DNA polymerase III, epsilon subunit	dnaQ	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0016020,GO:0030312,GO:0032991,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0071944,GO:1902494,GO:1905347,GO:1905348,GO:1990391	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	GIY-YIG,RNase_T,UVR
REGS2_k127_2256571_26	1128421.JAGA01000002_gene1461	7.729e-50	190.0	COG0648@1|root,COG0648@2|Bacteria,2NNN3@2323|unclassified Bacteria	2|Bacteria	L	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin	nfo	GO:0000726,GO:0003674,GO:0003824,GO:0003906,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008081,GO:0008150,GO:0008152,GO:0008833,GO:0009987,GO:0016787,GO:0016788,GO:0016888,GO:0016893,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
REGS2_k127_2256571_11	661087.HMPREF1008_01381	4.43e-109	370.0	COG0389@1|root,COG0389@2|Bacteria,2GKBI@201174|Actinobacteria,4CUNP@84998|Coriobacteriia	84998|Coriobacteriia	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
REGS2_k127_2256571_1	643648.Slip_2141	5.163e-225	737.0	COG0587@1|root,COG0587@2|Bacteria,1TPYG@1239|Firmicutes,247U0@186801|Clostridia,42JI1@68298|Syntrophomonadaceae	186801|Clostridia	L	TIGRFAM DNA polymerase III, alpha subunit	dnaE	-	2.7.7.7	ko:K02337,ko:K14162	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
REGS2_k127_2256571_43	28444.JODQ01000016_gene7094	7.626e-08	59.0	2ERD0@1|root,33IYN@2|Bacteria,2GVR1@201174|Actinobacteria,4EKQG@85012|Streptosporangiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS2_k127_2256571_20	871963.Desdi_1158	1.462e-60	228.0	COG3437@1|root,COG3437@2|Bacteria,1V7YT@1239|Firmicutes,25E5I@186801|Clostridia	186801|Clostridia	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HD,HD_5
REGS2_k127_2256571_28	1227457.C451_19093	3.603e-39	154.0	COG1321@1|root,arCOG02099@2157|Archaea,2XSWC@28890|Euryarchaeota,23S1S@183963|Halobacteria	183963|Halobacteria	K	COG1321 Mn-dependent transcriptional regulator	sirR	-	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,Fe_dep_repress,FeoA
REGS2_k127_2256571_33	879310.HMPREF9162_1344	2.148e-33	134.0	COG0720@1|root,COG0720@2|Bacteria,1VAJX@1239|Firmicutes	1239|Firmicutes	H	PFAM 6-pyruvoyl tetrahydropterin synthase	queD	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
REGS2_k127_2256571_29	644966.Tmar_2073	8.556e-38	146.0	COG0328@1|root,COG0328@2|Bacteria,1VAJW@1239|Firmicutes,24NJ8@186801|Clostridia	186801|Clostridia	L	PFAM ribonuclease H	rnhA	-	3.1.26.4	ko:K03469,ko:K06864	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RVT_3
REGS2_k127_2256571_38	502558.EGYY_17510	2.362e-19	96.0	COG1579@1|root,COG1579@2|Bacteria,2HTFI@201174|Actinobacteria,4CVXI@84998|Coriobacteriia	84998|Coriobacteriia	S	zinc ribbon domain	-	-	-	ko:K07164	-	-	-	-	ko00000	-	-	-	zf-RING_7
REGS2_k127_2256571_22	471853.Bcav_1828	1.136e-54	209.0	COG0327@1|root,COG3323@1|root,COG0327@2|Bacteria,COG3323@2|Bacteria,2GKHZ@201174|Actinobacteria	201174|Actinobacteria	L	Belongs to the GTP cyclohydrolase I type 2 NIF3 family	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	-	-	-	-	-	-	-	-	-	NIF3
REGS2_k127_2256571_15	1121468.AUBR01000006_gene354	8.433e-74	262.0	COG1387@1|root,COG1387@2|Bacteria,1UZ0M@1239|Firmicutes,24FSN@186801|Clostridia,42FB9@68295|Thermoanaerobacterales	186801|Clostridia	E	TIGRFAM histidinol phosphate phosphatase HisJ	hisJ	-	3.1.3.15	ko:K04486	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03013	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PHP,PHP_C
REGS2_k127_2256571_12	864563.HMPREF9166_0037	9.408e-87	298.0	COG0482@1|root,COG0482@2|Bacteria,1TPIZ@1239|Firmicutes,4H2P5@909932|Negativicutes	909932|Negativicutes	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
REGS2_k127_2256571_27	565033.GACE_1086	4.192e-46	177.0	COG0822@1|root,arCOG02077@2157|Archaea,2XX32@28890|Euryarchaeota,2467Y@183980|Archaeoglobi	183980|Archaeoglobi	C	NifU-like N terminal domain	-	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
REGS2_k127_2256571_8	246194.CHY_2199	5.799e-131	434.0	COG1104@1|root,COG1104@2|Bacteria,1TP21@1239|Firmicutes,24888@186801|Clostridia,42FGX@68295|Thermoanaerobacterales	186801|Clostridia	H	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
REGS2_k127_2256571_36	264732.Moth_1653	7.538e-30	124.0	COG1959@1|root,COG1959@2|Bacteria,1V3QB@1239|Firmicutes,24JIV@186801|Clostridia,42GCN@68295|Thermoanaerobacterales	186801|Clostridia	K	TIGRFAM transcriptional regulator, Rrf2 family	cymR	-	-	-	-	-	-	-	-	-	-	-	Rrf2
REGS2_k127_2256571_18	1121428.DESHY_10214___1	2.066e-67	232.0	COG0054@1|root,COG0054@2|Bacteria,1V1DA@1239|Firmicutes,24FRS@186801|Clostridia,261H1@186807|Peptococcaceae	186801|Clostridia	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	-	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
REGS2_k127_2256571_7	635013.TherJR_1781	3.477e-159	514.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1TPH9@1239|Firmicutes,248B0@186801|Clostridia,260I8@186807|Peptococcaceae	186801|Clostridia	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribBA	-	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS10830	DHBP_synthase,GTP_cyclohydro2
REGS2_k127_2256571_23	1232410.KI421413_gene683	7.441e-53	202.0	COG0307@1|root,COG0307@2|Bacteria,1MUMB@1224|Proteobacteria,42QT1@68525|delta/epsilon subdivisions,2WNK6@28221|Deltaproteobacteria,43UI4@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Lumazine binding domain	ribE	-	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	Lum_binding
REGS2_k127_2256571_17	743721.Psesu_0620	1.035e-69	250.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1MUWT@1224|Proteobacteria,1RN2M@1236|Gammaproteobacteria,1X30V@135614|Xanthomonadales	135614|Xanthomonadales	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	ribD	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
REGS2_k127_2256571_2	1183438.GKIL_0318	1.266e-211	704.0	COG0642@1|root,COG1352@1|root,COG2201@1|root,COG1352@2|Bacteria,COG2201@2|Bacteria,COG2205@2|Bacteria,1G09B@1117|Cyanobacteria	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	2.1.1.80,3.1.1.61	ko:K13924	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,CheR,CheR_N,GAF,HATPase_c,HisKA,PAS_10,PAS_3,PAS_4,PAS_9,Response_reg
REGS2_k127_2256571_9	177439.DP1382	2.036e-117	388.0	COG1162@1|root,COG1162@2|Bacteria,1MUEF@1224|Proteobacteria,42MQV@68525|delta/epsilon subdivisions,2WIZC@28221|Deltaproteobacteria,2MIQG@213118|Desulfobacterales	28221|Deltaproteobacteria	S	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit	rsgA	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	RsgA_GTPase
REGS2_k127_2256571_14	1536775.H70737_11985	1.252e-75	265.0	COG0036@1|root,COG0036@2|Bacteria,1TQK8@1239|Firmicutes,4H9RW@91061|Bacilli,26Q92@186822|Paenibacillaceae	91061|Bacilli	G	Belongs to the ribulose-phosphate 3-epimerase family	rpe	GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046496,GO:0046872,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
REGS2_k127_2256571_24	1121468.AUBR01000051_gene1998	8.446e-53	191.0	COG0240@1|root,COG0240@2|Bacteria,1TQ5P@1239|Firmicutes,248JT@186801|Clostridia,42FM7@68295|Thermoanaerobacterales	186801|Clostridia	I	Glycerol-3-phosphate dehydrogenase	gpsA	-	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
REGS2_k127_2392567_12	653386.HMPREF0975_01030	6.66e-30	125.0	COG1695@1|root,COG1695@2|Bacteria,2I8DQ@201174|Actinobacteria,4D5Q3@85005|Actinomycetales	201174|Actinobacteria	K	Virulence activator alpha C-term	padR	-	-	-	-	-	-	-	-	-	-	-	PadR,Vir_act_alpha_C
REGS2_k127_2392567_3	1242864.D187_007330	1.917e-149	504.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,42N2U@68525|delta/epsilon subdivisions,2WJRR@28221|Deltaproteobacteria,2YZ20@29|Myxococcales	28221|Deltaproteobacteria	P	ABC transporter transmembrane region	-	-	-	ko:K06147,ko:K18890	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
REGS2_k127_2392567_1	1242864.D187_007328	3.244e-169	551.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,42M01@68525|delta/epsilon subdivisions,2WJ7M@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation	-	-	-	ko:K06147,ko:K18889	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
REGS2_k127_2392567_5	68260.JOAY01000025_gene1147	2.462e-57	218.0	COG0697@1|root,COG0697@2|Bacteria,2I91Y@201174|Actinobacteria	201174|Actinobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
REGS2_k127_2392567_10	3055.EDP04354	9.071e-35	144.0	COG1051@1|root,2S8UU@2759|Eukaryota,3802D@33090|Viridiplantae,34KRZ@3041|Chlorophyta	3041|Chlorophyta	G	NUDIX domain	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
REGS2_k127_2392567_2	401526.TcarDRAFT_0324	7.854e-155	498.0	COG1900@1|root,COG1900@2|Bacteria,1TRBF@1239|Firmicutes,4H6ZP@909932|Negativicutes	909932|Negativicutes	S	Homocysteine biosynthesis enzyme, sulfur-incorporation	-	-	-	-	-	-	-	-	-	-	-	-	HcyBio
REGS2_k127_2392567_11	582515.KR51_00000730	2.033e-31	127.0	COG1135@1|root,COG1145@1|root,COG1135@2|Bacteria,COG1145@2|Bacteria,1G5Q2@1117|Cyanobacteria	1117|Cyanobacteria	C	NIL domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,NIL
REGS2_k127_2392567_0	243231.GSU2921	1.725e-186	610.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,42NHZ@68525|delta/epsilon subdivisions,2WJ2H@28221|Deltaproteobacteria,43U7R@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Methionine synthase B12-binding module cap domain protein	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
REGS2_k127_2392567_6	269799.Gmet_1161	5.049e-49	183.0	COG4656@1|root,COG4656@2|Bacteria,1MWAX@1224|Proteobacteria,42NJM@68525|delta/epsilon subdivisions,2WKM6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM Methylene-tetrahydrofolate reductase C terminal	-	-	-	-	-	-	-	-	-	-	-	-	MTHFR_C
REGS2_k127_2392567_4	243231.GSU0860	3.836e-72	260.0	COG0685@1|root,COG0685@2|Bacteria,1MXTZ@1224|Proteobacteria,42NTS@68525|delta/epsilon subdivisions,2WK04@28221|Deltaproteobacteria,43V05@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Methylenetetrahydrofolate reductase	metF-1	-	1.5.1.20,2.1.1.10	ko:K00297,ko:K00547	ko00270,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01523,map00270,map00670,map00720,map01100,map01110,map01120,map01200,map01523	M00377	R00650,R01224,R07168	RC00003,RC00035,RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
REGS2_k127_2392567_8	395495.Lcho_0302	7.671e-40	168.0	COG1752@1|root,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,2VK14@28216|Betaproteobacteria,1KK0K@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	esterase of the alpha-beta hydrolase superfamily	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
REGS2_k127_2392567_9	1123253.AUBD01000002_gene1253	2.436e-39	162.0	COG1752@1|root,COG4775@1|root,COG1752@2|Bacteria,COG4775@2|Bacteria,1MUM9@1224|Proteobacteria,1RRSK@1236|Gammaproteobacteria,1X39X@135614|Xanthomonadales	135614|Xanthomonadales	M	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Bac_surface_Ag,Patatin
REGS2_k127_2392567_7	700015.Corgl_0460	4.127e-45	174.0	COG0476@1|root,COG0476@2|Bacteria,2GJB6@201174|Actinobacteria,4CX1G@84998|Coriobacteriia	84998|Coriobacteriia	H	PFAM UBA THIF-type NAD FAD binding protein	-	-	2.7.7.73	ko:K03148	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF
REGS2_k127_2392567_13	690850.Desaf_1712	3.963e-10	63.0	COG1977@1|root,COG1977@2|Bacteria,1NH6M@1224|Proteobacteria,42X05@68525|delta/epsilon subdivisions,2WSK5@28221|Deltaproteobacteria,2MD55@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	PFAM ThiamineS	-	-	-	-	-	-	-	-	-	-	-	-	ThiS,Ub-Mut7C
REGS2_k127_2460090_8	1449126.JQKL01000005_gene901	4.108e-116	386.0	COG0399@1|root,COG0399@2|Bacteria,1TPDH@1239|Firmicutes,24862@186801|Clostridia,26B30@186813|unclassified Clostridiales	186801|Clostridia	E	Beta-eliminating lyase	degT1	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
REGS2_k127_2460090_16	1449126.JQKL01000005_gene900	5.97e-74	260.0	COG1044@1|root,COG1044@2|Bacteria,1UHYP@1239|Firmicutes,25E78@186801|Clostridia	186801|Clostridia	M	Bacterial transferase hexapeptide	-	-	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,Hexapep_2
REGS2_k127_2460090_9	1379698.RBG1_1C00001G1537	7.775e-99	346.0	COG0673@1|root,COG0673@2|Bacteria,2NP38@2323|unclassified Bacteria	2|Bacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	2.3.1.201	ko:K13018	ko00520,map00520	-	R10100	RC00004,RC00166	ko00000,ko00001,ko01000,ko01005	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C,Hexapep,Hexapep_2
REGS2_k127_2460090_4	768710.DesyoDRAFT_5079	1.112e-153	507.0	COG0677@1|root,COG0677@2|Bacteria,1TPXY@1239|Firmicutes,248NW@186801|Clostridia,2606B@186807|Peptococcaceae	186801|Clostridia	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	-	-	1.1.1.136	ko:K13015	ko00520,map00520	-	R00421	RC00291	ko00000,ko00001,ko01000,ko01005	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
REGS2_k127_2460090_20	471875.RUMLAC_02535	6.395e-48	177.0	COG0764@1|root,COG0764@2|Bacteria,1V6EX@1239|Firmicutes,24JAW@186801|Clostridia,3WJ8D@541000|Ruminococcaceae	186801|Clostridia	I	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs	fabZ	-	4.2.1.59	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
REGS2_k127_2460090_5	1504822.CCNO01000008_gene1933	1.266e-150	490.0	COG0766@1|root,COG0766@2|Bacteria,2NNUV@2323|unclassified Bacteria	2|Bacteria	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	GO:0008150,GO:0040007	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
REGS2_k127_2460090_25	1121428.DESHY_30126___1	6.606e-23	107.0	COG0355@1|root,COG0355@2|Bacteria,1VA89@1239|Firmicutes,24ND7@186801|Clostridia,2629N@186807|Peptococcaceae	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	iHN637.CLJU_RS01195	ATP-synt_DE,ATP-synt_DE_N
REGS2_k127_2460090_1	633147.Olsu_0138	6.664e-225	704.0	COG0055@1|root,COG0055@2|Bacteria,2GIY6@201174|Actinobacteria,4CV4C@84998|Coriobacteriia	84998|Coriobacteriia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
REGS2_k127_2460090_15	479437.Elen_1044	1.208e-74	278.0	COG0224@1|root,COG0224@2|Bacteria,2GJ7Q@201174|Actinobacteria,4CUP6@84998|Coriobacteriia	84998|Coriobacteriia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	-	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
REGS2_k127_2460090_0	1384484.AEQU_0743	5.454e-247	771.0	COG0056@1|root,COG0056@2|Bacteria,2GJRJ@201174|Actinobacteria,4CU9G@84998|Coriobacteriia	84998|Coriobacteriia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
REGS2_k127_2460090_26	1034345.CAEM01000026_gene1039	9.746e-22	104.0	COG0712@1|root,COG0712@2|Bacteria,2HUWA@201174|Actinobacteria,4CVUZ@84998|Coriobacteriia	84998|Coriobacteriia	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	-	-	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	OSCP
REGS2_k127_2460090_23	742818.HMPREF9451_01309	4.011e-39	151.0	COG0711@1|root,COG0711@2|Bacteria,2HUVJ@201174|Actinobacteria,4CVSF@84998|Coriobacteriia	84998|Coriobacteriia	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	atpF	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
REGS2_k127_2460090_27	883169.HMPREF9719_00912	5.309e-17	83.0	COG0636@1|root,COG0636@2|Bacteria,2GQI6@201174|Actinobacteria,22NUS@1653|Corynebacteriaceae	201174|Actinobacteria	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpE	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_C
REGS2_k127_2460090_21	521003.COLINT_03378	1.325e-46	183.0	COG0356@1|root,COG0356@2|Bacteria,2H3PR@201174|Actinobacteria,4CV2N@84998|Coriobacteriia	84998|Coriobacteriia	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
REGS2_k127_2460090_13	521003.COLINT_02126	6.4e-84	298.0	COG0472@1|root,COG0472@2|Bacteria,2GIT7@201174|Actinobacteria,4CUG4@84998|Coriobacteriia	84998|Coriobacteriia	M	Glycosyltransferase, group 4 family	-	-	2.7.8.33,2.7.8.35	ko:K02851	-	-	R08856	RC00002	ko00000,ko01000,ko01003,ko01005	-	-	-	Glycos_transf_4
REGS2_k127_2460090_18	696369.KI912183_gene2117	4.372e-64	224.0	COG2131@1|root,COG2131@2|Bacteria,1V3PU@1239|Firmicutes,24HF0@186801|Clostridia,261R0@186807|Peptococcaceae	186801|Clostridia	F	PFAM Cytidine and deoxycytidylate deaminase zinc-binding region	comEB	-	3.5.4.12	ko:K01493	ko00240,ko01100,map00240,map01100	M00429	R01663	RC00074	ko00000,ko00001,ko00002,ko01000,ko02044	-	-	-	dCMP_cyt_deam_1
REGS2_k127_2460090_12	857293.CAAU_0362	1.917e-92	309.0	COG0035@1|root,COG0035@2|Bacteria,1TPMT@1239|Firmicutes,248FV@186801|Clostridia,36DZ9@31979|Clostridiaceae	186801|Clostridia	F	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate	upp	-	2.4.2.9	ko:K00761	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000	-	-	-	UPRTase
REGS2_k127_2460090_3	262543.Exig_2693	1.81e-183	582.0	COG0112@1|root,COG0112@2|Bacteria,1TQVM@1239|Firmicutes,4HA5K@91061|Bacilli,3WE62@539002|Bacillales incertae sedis	91061|Bacilli	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
REGS2_k127_2460090_22	502558.EGYY_21090	9.672e-46	174.0	COG0698@1|root,COG0698@2|Bacteria,2GKJG@201174|Actinobacteria,4CVWB@84998|Coriobacteriia	84998|Coriobacteriia	G	isomerase B	rpiB	-	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	LacAB_rpiB
REGS2_k127_2460090_19	742818.HMPREF9451_01327	4.63e-50	186.0	COG0009@1|root,COG0009@2|Bacteria,2GK2X@201174|Actinobacteria,4CW4P@84998|Coriobacteriia	84998|Coriobacteriia	J	Sua5 YciO YrdC YwlC family	-	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	Sua5_yciO_yrdC
REGS2_k127_2460090_17	1235794.C811_00700	2.028e-73	256.0	COG2890@1|root,COG2890@2|Bacteria,2GMH1@201174|Actinobacteria,4CUEA@84998|Coriobacteriia	84998|Coriobacteriia	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS,Methyltransf_31,Sua5_yciO_yrdC
REGS2_k127_2460090_6	1384484.AEQU_1136	6.283e-144	465.0	COG0216@1|root,COG0216@2|Bacteria,2GJWG@201174|Actinobacteria,4CUGQ@84998|Coriobacteriia	84998|Coriobacteriia	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
REGS2_k127_2460090_10	471855.Shel_20010	1.892e-98	332.0	COG3872@1|root,COG3872@2|Bacteria,2IIWY@201174|Actinobacteria,4CVDS@84998|Coriobacteriia	84998|Coriobacteriia	S	Protein of unknown function (DUF1385)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1385
REGS2_k127_2460090_11	1384484.AEQU_1380	1.518e-97	324.0	COG1351@1|root,COG1351@2|Bacteria,2HCNJ@201174|Actinobacteria,4CV8N@84998|Coriobacteriia	84998|Coriobacteriia	H	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant	thyX	-	2.1.1.148	ko:K03465	ko00240,ko00670,ko01100,map00240,map00670,map01100	-	R06613	RC00022,RC00332	ko00000,ko00001,ko01000	-	-	-	Thy1
REGS2_k127_2460090_24	521003.COLINT_02779	1.796e-34	139.0	COG0254@1|root,COG0254@2|Bacteria,2HUWQ@201174|Actinobacteria,4CVW5@84998|Coriobacteriia	84998|Coriobacteriia	J	Binds the 23S rRNA	rpmE	-	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
REGS2_k127_2460090_2	1163617.SCD_n00428	2.203e-193	617.0	COG0433@1|root,COG0433@2|Bacteria,1MU59@1224|Proteobacteria,2VIJY@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Bacterial protein of unknown function (DUF853)	yjgR	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF853
REGS2_k127_2460090_7	1122951.ATUE01000005_gene2187	1.762e-122	408.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,3NIUV@468|Moraxellaceae	1236|Gammaproteobacteria	L	Belongs to the DEAD box helicase family	rhlE	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006950,GO:0006996,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0010501,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0042254,GO:0042255,GO:0042623,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0065003,GO:0070035,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0140098,GO:1901360	3.6.4.13	ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DEAD,Helicase_C
REGS2_k127_2460090_14	1463903.JOIZ01000006_gene5200	1.487e-75	256.0	COG1158@1|root,COG1158@2|Bacteria,2GIWY@201174|Actinobacteria	201174|Actinobacteria	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006351,GO:0006353,GO:0006360,GO:0006363,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0018130,GO:0019438,GO:0030312,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
REGS2_k127_2715638_10	408672.NBCG_01629	2.68e-40	159.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
REGS2_k127_2715638_4	1379698.RBG1_1C00001G1206	3.421e-78	274.0	COG1215@1|root,COG1215@2|Bacteria,2NQN7@2323|unclassified Bacteria	2|Bacteria	M	Glycosyltransferase like family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
REGS2_k127_2715638_0	768706.Desor_1039	1.162e-168	556.0	COG0493@1|root,COG0493@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,260CB@186807|Peptococcaceae	186801|Clostridia	C	glutamate synthase (NADPH), homotetrameric	gltA	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
REGS2_k127_2715638_3	1125712.HMPREF1316_1152	6.908e-86	293.0	COG0543@1|root,COG0543@2|Bacteria,2I6AM@201174|Actinobacteria,4CUND@84998|Coriobacteriia	84998|Coriobacteriia	C	domain protein	-	-	1.18.1.2,1.19.1.1	ko:K00528	-	-	R10159	-	ko00000,ko01000	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
REGS2_k127_2715638_13	1125863.JAFN01000001_gene3582	1.703e-30	136.0	COG1477@1|root,COG1477@2|Bacteria,1MW6K@1224|Proteobacteria,42MZQ@68525|delta/epsilon subdivisions,2WJNE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	-	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
REGS2_k127_2715638_15	926569.ANT_20810	1.099e-06	55.0	COG4818@1|root,COG4818@2|Bacteria,2G9PA@200795|Chloroflexi	200795|Chloroflexi	S	Domain of unknown function (DUF4870)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4870
REGS2_k127_2715638_7	1089553.Tph_c06550	2.428e-52	201.0	COG4942@1|root,COG4942@2|Bacteria,1TQ5I@1239|Firmicutes,248ZG@186801|Clostridia,42FSF@68295|Thermoanaerobacterales	186801|Clostridia	D	PFAM Peptidase M23	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
REGS2_k127_2715638_5	479434.Sthe_1941	2.366e-61	223.0	COG0745@1|root,COG0745@2|Bacteria,2G8EP@200795|Chloroflexi	200795|Chloroflexi	K	Transcriptional regulatory protein, C terminal	-	-	-	ko:K07667	ko02020,ko02024,map02020,map02024	M00454	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
REGS2_k127_2715638_11	243231.GSU2483	4.578e-39	167.0	COG0642@1|root,COG2205@2|Bacteria,1MUZQ@1224|Proteobacteria,42NZF@68525|delta/epsilon subdivisions,2WJNR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase	kdpD	-	2.7.13.3	ko:K07646	ko02020,map02020	M00454	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF4118,GAF_3,HATPase_c,HisKA,KdpD,Usp
REGS2_k127_2715638_6	469378.Ccur_03980	8.031e-55	202.0	COG0193@1|root,COG0193@2|Bacteria,2GKCV@201174|Actinobacteria,4CV7A@84998|Coriobacteriia	84998|Coriobacteriia	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	-	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
REGS2_k127_2715638_12	1198232.CYCME_0725	2.445e-35	146.0	COG1825@1|root,COG1825@2|Bacteria,1RDH0@1224|Proteobacteria,1S46A@1236|Gammaproteobacteria,460JE@72273|Thiotrichales	72273|Thiotrichales	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	-	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
REGS2_k127_2715638_2	1209989.TepiRe1_0094	1.48e-106	364.0	COG0462@1|root,COG0462@2|Bacteria,1TQ6Q@1239|Firmicutes,248ZN@186801|Clostridia,42EXR@68295|Thermoanaerobacterales	186801|Clostridia	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
REGS2_k127_2715638_1	471855.Shel_21940	2.435e-140	459.0	COG1207@1|root,COG1207@2|Bacteria,2GJS1@201174|Actinobacteria,4CUFP@84998|Coriobacteriia	84998|Coriobacteriia	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,Hexapep_2,NTP_transf_3,NTP_transferase
REGS2_k127_2715638_14	1391647.AVSV01000016_gene1045	1.036e-22	101.0	COG2088@1|root,COG2088@2|Bacteria,1V9ZG@1239|Firmicutes,24MVQ@186801|Clostridia,36JKP@31979|Clostridiaceae	186801|Clostridia	D	Could be involved in septation	spoVG	-	-	ko:K06412	-	-	-	-	ko00000	-	-	-	SpoVG
REGS2_k127_2715638_8	1121423.JONT01000015_gene1338	6.695e-45	173.0	COG0746@1|root,COG0746@2|Bacteria,1V4AK@1239|Firmicutes,249SR@186801|Clostridia,267CR@186807|Peptococcaceae	186801|Clostridia	H	MobA-like NTP transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_3
REGS2_k127_2715638_9	644282.Deba_0725	9.847e-42	164.0	COG1947@1|root,COG1947@2|Bacteria,1MVU3@1224|Proteobacteria,42RGS@68525|delta/epsilon subdivisions,2WNJR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	ispE	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0050515	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
REGS2_k127_2761972_7	1303692.SFUL_3249	9.814e-54	199.0	COG4932@1|root,COG4932@2|Bacteria,2GJ4T@201174|Actinobacteria	201174|Actinobacteria	M	Protein of unknown function (DUF3494)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3494
REGS2_k127_2761972_12	87626.PTD2_04958	0.0001548	46.0	2DTNT@1|root,33M3P@2|Bacteria,1NH3S@1224|Proteobacteria,1SGZB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS2_k127_2761972_8	1123024.AUII01000004_gene1499	9.695e-23	100.0	COG2026@1|root,COG2026@2|Bacteria,2GRQR@201174|Actinobacteria	201174|Actinobacteria	DJ	PFAM plasmid stabilization system	-	-	-	-	-	-	-	-	-	-	-	-	ParE_toxin
REGS2_k127_2761972_9	477641.MODMU_2530	9.981e-15	78.0	COG2161@1|root,COG2161@2|Bacteria,2GZ91@201174|Actinobacteria,4EWWR@85013|Frankiales	201174|Actinobacteria	D	Antitoxin component of a toxin-antitoxin (TA) module	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
REGS2_k127_2761972_0	1203602.HMPREF1527_01017	5.701e-181	590.0	COG0138@1|root,COG0138@2|Bacteria,2GJWU@201174|Actinobacteria,4CV0C@84998|Coriobacteriia	84998|Coriobacteriia	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
REGS2_k127_2761972_11	1380387.JADM01000008_gene831	6.475e-07	62.0	COG0115@1|root,COG0115@2|Bacteria,1MZAK@1224|Proteobacteria,1RPPG@1236|Gammaproteobacteria,1XK0U@135619|Oceanospirillales	135619|Oceanospirillales	EH	Branched-chain amino acid aminotransferase 4-amino-4-deoxychorismate lyase	pabC	-	4.1.3.38	ko:K02619	ko00790,map00790	-	R05553	RC01843,RC02148	ko00000,ko00001,ko01000	-	-	-	Aminotran_4
REGS2_k127_2761972_6	471855.Shel_01770	1.197e-58	217.0	COG0299@1|root,COG0299@2|Bacteria,2H8QB@201174|Actinobacteria,4CUUR@84998|Coriobacteriia	84998|Coriobacteriia	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	purN	-	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	Formyl_trans_N
REGS2_k127_2761972_10	1504319.GM45_0850	4.067e-10	69.0	COG1376@1|root,COG1376@2|Bacteria,2IIU7@201174|Actinobacteria,3UXH1@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
REGS2_k127_2761972_2	479437.Elen_0725	2.745e-139	451.0	COG0150@1|root,COG0150@2|Bacteria,2GJNY@201174|Actinobacteria,4CUJR@84998|Coriobacteriia	84998|Coriobacteriia	F	Phosphoribosylformylglycinamidine cyclo-ligase	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
REGS2_k127_2761972_4	351160.RCIX872	7.001e-86	306.0	COG2234@1|root,arCOG02959@2157|Archaea	2157|Archaea	S	Peptidase M28	ywaD2	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
REGS2_k127_2761972_5	926554.KI912643_gene1431	3.691e-64	240.0	COG0688@1|root,COG0688@2|Bacteria	2|Bacteria	I	phosphatidylethanolamine metabolic process	psd	-	4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PS_Dcarbxylase
REGS2_k127_2761972_3	264732.Moth_0454	2.017e-87	309.0	COG2170@1|root,COG2170@2|Bacteria,1VUBC@1239|Firmicutes,24XQG@186801|Clostridia,42I2W@68295|Thermoanaerobacterales	186801|Clostridia	S	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS2_k127_2761972_1	391612.CY0110_23636	7.757e-161	522.0	COG0034@1|root,COG0034@2|Bacteria,1G1C9@1117|Cyanobacteria,3KGUR@43988|Cyanothece	1117|Cyanobacteria	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
REGS2_k127_2767080_4	1255043.TVNIR_3052	3.086e-160	514.0	COG0686@1|root,COG0686@2|Bacteria,1QTX1@1224|Proteobacteria,1T1JB@1236|Gammaproteobacteria,1WXVZ@135613|Chromatiales	135613|Chromatiales	C	Belongs to the AlaDH PNT family	-	-	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
REGS2_k127_2767080_11	269800.Tfu_1772	5.254e-82	287.0	COG3502@1|root,COG3502@2|Bacteria,2H2JJ@201174|Actinobacteria,4EFJW@85012|Streptosporangiales	201174|Actinobacteria	S	Protein of unknown function (DUF3866)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3866
REGS2_k127_2767080_9	479437.Elen_0957	1.323e-95	341.0	COG2195@1|root,COG2195@2|Bacteria,2HNP3@201174|Actinobacteria,4CVCK@84998|Coriobacteriia	84998|Coriobacteriia	E	Peptidase dimerisation domain	-	-	3.4.11.4	ko:K01258	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
REGS2_k127_2767080_1	246194.CHY_0125	2.365e-248	777.0	COG0504@1|root,COG0504@2|Bacteria,1TP34@1239|Firmicutes,2482E@186801|Clostridia,42F21@68295|Thermoanaerobacterales	186801|Clostridia	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS01075	CTP_synth_N,GATase
REGS2_k127_2767080_21	1304865.JAGF01000001_gene3648	6.092e-33	140.0	COG0472@1|root,COG0472@2|Bacteria,2HS8K@201174|Actinobacteria,4F156@85016|Cellulomonadaceae	201174|Actinobacteria	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS2_k127_2767080_17	477974.Daud_1083	3.386e-54	217.0	COG3119@1|root,COG3119@2|Bacteria,1TSMM@1239|Firmicutes,247YU@186801|Clostridia,260J3@186807|Peptococcaceae	186801|Clostridia	P	arylsulfatase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS2_k127_2767080_8	502558.EGYY_10420	3.762e-99	345.0	COG0728@1|root,COG0728@2|Bacteria,2GKN0@201174|Actinobacteria,4CUPY@84998|Coriobacteriia	84998|Coriobacteriia	S	integral membrane protein MviN	-	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
REGS2_k127_2767080_15	1121428.DESHY_60112___1	1.112e-67	238.0	COG1215@1|root,COG1215@2|Bacteria,1TPBB@1239|Firmicutes,25E7R@186801|Clostridia,266RZ@186807|Peptococcaceae	186801|Clostridia	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
REGS2_k127_2767080_26	1380356.JNIK01000015_gene2714	7.99e-09	68.0	2D1T0@1|root,32TBA@2|Bacteria,2I8E5@201174|Actinobacteria,4ET7I@85013|Frankiales	201174|Actinobacteria	S	Copper transport outer membrane protein, MctB	mctB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0008150,GO:0009279,GO:0015267,GO:0015288,GO:0016020,GO:0016021,GO:0019867,GO:0022803,GO:0022829,GO:0022857,GO:0030312,GO:0030313,GO:0031224,GO:0031975,GO:0032991,GO:0044425,GO:0044462,GO:0044464,GO:0046930,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098796	-	-	-	-	-	-	-	-	-	-	MctB
REGS2_k127_2767080_5	526225.Gobs_3007	9.635e-131	428.0	COG4825@1|root,COG4825@2|Bacteria,2GPAA@201174|Actinobacteria,4ERVF@85013|Frankiales	201174|Actinobacteria	S	Thiamine pyrophosphokinase C terminal	-	-	-	-	-	-	-	-	-	-	-	-	TPPK_C
REGS2_k127_2767080_6	633147.Olsu_1109	5.189e-119	404.0	COG0497@1|root,COG0497@2|Bacteria,2GIVG@201174|Actinobacteria,4CUSR@84998|Coriobacteriia	84998|Coriobacteriia	L	May be involved in recombinational repair of damaged DNA	recN	-	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,SMC_N
REGS2_k127_2767080_19	742818.HMPREF9451_01115	9.783e-46	177.0	COG0061@1|root,COG0061@2|Bacteria,2GKM2@201174|Actinobacteria,4CVSJ@84998|Coriobacteriia	84998|Coriobacteriia	H	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
REGS2_k127_2767080_14	1121468.AUBR01000002_gene653	1.618e-72	254.0	COG1189@1|root,COG1189@2|Bacteria,1TPE4@1239|Firmicutes,247VH@186801|Clostridia,42FIN@68295|Thermoanaerobacterales	186801|Clostridia	J	Ribosomal RNA methyltransferase RrmJ FtsJ	rrmJ	-	2.1.1.226,2.1.1.227	ko:K06442	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ,S4
REGS2_k127_2767080_2	760568.Desku_1927	7.65e-229	726.0	COG1154@1|root,COG1154@2|Bacteria,1TP37@1239|Firmicutes,247P1@186801|Clostridia,2604R@186807|Peptococcaceae	186801|Clostridia	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
REGS2_k127_2767080_27	555079.Toce_1309	2.681e-05	51.0	COG1722@1|root,COG1722@2|Bacteria,1VK9I@1239|Firmicutes,24UH5@186801|Clostridia,42HHZ@68295|Thermoanaerobacterales	186801|Clostridia	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseB	-	3.1.11.6	ko:K03602	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_S
REGS2_k127_2767080_20	479437.Elen_2539	1.23e-34	140.0	COG0781@1|root,COG0781@2|Bacteria,2IM3D@201174|Actinobacteria,4CWB5@84998|Coriobacteriia	84998|Coriobacteriia	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
REGS2_k127_2767080_23	649764.HMPREF0762_00745	7.956e-20	93.0	COG1302@1|root,COG1302@2|Bacteria,2HV5F@201174|Actinobacteria,4CWCD@84998|Coriobacteriia	84998|Coriobacteriia	S	Asp23 family, cell envelope-related function	-	-	-	-	-	-	-	-	-	-	-	-	Asp23
REGS2_k127_2767080_3	321327.CYA_0852	1.384e-186	597.0	COG0439@1|root,COG0439@2|Bacteria,1G1M0@1117|Cyanobacteria,1GYGC@1129|Synechococcus	1117|Cyanobacteria	I	Biotin carboxylase	accC	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
REGS2_k127_2767080_0	1384484.AEQU_0607	1.369e-266	836.0	COG0511@1|root,COG5016@1|root,COG0511@2|Bacteria,COG5016@2|Bacteria,2IR3V@201174|Actinobacteria,4CUB4@84998|Coriobacteriia	84998|Coriobacteriia	CI	Acetyl-CoA carboxylase, biotin carboxyl carrier protein	-	-	4.1.1.3	ko:K01571	ko00620,ko01100,map00620,map01100	-	R00217	RC00040	ko00000,ko00001,ko01000,ko02000	3.B.1.1.1	-	-	Biotin_lipoyl,HMGL-like,PYC_OADA
REGS2_k127_2767080_13	525256.HMPREF0091_10446	2.962e-75	258.0	COG0231@1|root,COG0231@2|Bacteria,2GJMS@201174|Actinobacteria,4CV48@84998|Coriobacteriia	84998|Coriobacteriia	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	efp	-	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
REGS2_k127_2767080_10	1120972.AUMH01000003_gene2874	1.72e-83	292.0	COG0006@1|root,COG0006@2|Bacteria,1TQ44@1239|Firmicutes,4HAT7@91061|Bacilli,27894@186823|Alicyclobacillaceae	91061|Bacilli	E	Creatinase/Prolidase N-terminal domain	pepP	-	3.4.11.9,3.4.13.9	ko:K01262,ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
REGS2_k127_2767080_18	1122919.KB905548_gene2368	1.089e-53	193.0	COG0757@1|root,COG0757@2|Bacteria,1V6E8@1239|Firmicutes,4HJ2V@91061|Bacilli,26XJ0@186822|Paenibacillaceae	91061|Bacilli	E	Catalyzes a trans-dehydration via an enolate intermediate	aroQ	-	4.2.1.10	ko:K03786	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_II
REGS2_k127_2767080_12	190650.CC_3009	2.226e-75	267.0	COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,2TRDA@28211|Alphaproteobacteria,2KFPW@204458|Caulobacterales	204458|Caulobacterales	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	4.2.3.4	ko:K01735	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03083	RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase
REGS2_k127_2767080_22	935845.JADQ01000063_gene149	7.18e-30	125.0	COG0703@1|root,COG0703@2|Bacteria,1VA6Z@1239|Firmicutes,4HKD6@91061|Bacilli,26Y94@186822|Paenibacillaceae	91061|Bacilli	E	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	aroK	GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	SKI
REGS2_k127_2767080_7	469378.Ccur_05150	1.561e-117	389.0	COG0082@1|root,COG0082@2|Bacteria,2GJJN@201174|Actinobacteria,4CUZR@84998|Coriobacteriia	84998|Coriobacteriia	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	-	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
REGS2_k127_2767080_24	42256.RradSPS_1470	2.498e-12	75.0	COG3167@1|root,COG3167@2|Bacteria	2|Bacteria	NU	carbon utilization	mshJ	-	-	ko:K02664,ko:K02665,ko:K12280	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilO,T2SSM,T2SSM_b
REGS2_k127_2767080_25	1121428.DESHY_60054___1	3.192e-10	69.0	COG3166@1|root,COG3166@2|Bacteria,1VEGW@1239|Firmicutes,24R7P@186801|Clostridia,2632U@186807|Peptococcaceae	186801|Clostridia	NU	PFAM Fimbrial assembly family protein	-	-	-	ko:K02663	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilN
REGS2_k127_2767080_16	351607.Acel_1313	6.55e-63	231.0	COG4972@1|root,COG4972@2|Bacteria,2IBNF@201174|Actinobacteria,4ET6Y@85013|Frankiales	201174|Actinobacteria	NU	Type IV pilus assembly protein PilM;	pilM	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilM_2
REGS2_k127_2813707_1	1384484.AEQU_1351	4.04e-129	421.0	COG1363@1|root,COG1363@2|Bacteria,2ID5X@201174|Actinobacteria,4CUPJ@84998|Coriobacteriia	84998|Coriobacteriia	G	M42 glutamyl aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M42
REGS2_k127_2813707_0	867903.ThesuDRAFT_00619	1.104e-165	545.0	COG0557@1|root,COG0557@2|Bacteria,1TQ1G@1239|Firmicutes,247ZS@186801|Clostridia,3WCE2@538999|Clostridiales incertae sedis	186801|Clostridia	K	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	OB_RNB,RNB,S1
REGS2_k127_2813707_5	1337936.IJ00_20640	5.207e-14	78.0	2AY0A@1|root,31Q1V@2|Bacteria,1G5XA@1117|Cyanobacteria,1HND8@1161|Nostocales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS2_k127_2813707_3	572547.Amico_1456	3.388e-73	261.0	COG0793@1|root,COG0793@2|Bacteria,3TA4G@508458|Synergistetes	508458|Synergistetes	M	Belongs to the peptidase S41A family	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_S41
REGS2_k127_2813707_4	1034345.CAEM01000018_gene361	7.526e-64	231.0	COG2177@1|root,COG2177@2|Bacteria,2GJMA@201174|Actinobacteria,4CU8U@84998|Coriobacteriia	84998|Coriobacteriia	D	Part of the ABC transporter FtsEX involved in cellular division	-	-	-	ko:K09811	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	FtsX
REGS2_k127_2813707_2	1111121.HMPREF1247_0491	3.376e-85	284.0	COG2884@1|root,COG2884@2|Bacteria,2GJE1@201174|Actinobacteria,4CUBJ@84998|Coriobacteriia	84998|Coriobacteriia	D	cell division ATP-binding protein FtsE	ftsE	-	-	ko:K09812	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	ABC_tran
REGS2_k127_2856742_21	929712.KI912613_gene4176	6.208e-38	156.0	COG1376@1|root,COG1376@2|Bacteria,2HPTN@201174|Actinobacteria,4CR7H@84995|Rubrobacteria	84995|Rubrobacteria	S	Putative peptidoglycan binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_4,YkuD
REGS2_k127_2856742_11	351160.LRC584	4.162e-54	205.0	COG1352@1|root,arCOG04402@2157|Archaea,2XU3Q@28890|Euryarchaeota,2N9NH@224756|Methanomicrobia	224756|Methanomicrobia	N	PFAM MCP methyltransferase CheR-type	cheR	-	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheR,CheR_N
REGS2_k127_2856742_9	1089553.Tph_c09690	1.189e-57	218.0	COG0840@1|root,COG3290@1|root,COG0840@2|Bacteria,COG3290@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia,42GHR@68295|Thermoanaerobacterales	186801|Clostridia	NT	histidine kinase HAMP region domain protein	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CHASE3,HAMP,MCPsignal,sCache_3_3
REGS2_k127_2856742_24	635013.TherJR_0110	9.291e-25	112.0	COG0835@1|root,COG0835@2|Bacteria,1V4HH@1239|Firmicutes,24JV4@186801|Clostridia,2623N@186807|Peptococcaceae	186801|Clostridia	NT	PFAM CheW domain protein	CheW	-	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
REGS2_k127_2856742_18	1120972.AUMH01000011_gene207	1.679e-41	163.0	COG2201@1|root,COG2201@2|Bacteria,1V3IU@1239|Firmicutes,4HGY2@91061|Bacilli,279U5@186823|Alicyclobacillaceae	91061|Bacilli	T	cheY-homologous receiver domain	cheY	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
REGS2_k127_2856742_7	1131451.O1K_08132	3.591e-79	277.0	COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,1RN67@1236|Gammaproteobacteria,1X3IE@135614|Xanthomonadales	135614|Xanthomonadales	NT	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	cheB	-	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,Response_reg
REGS2_k127_2856742_0	888060.HMPREF9081_2306	5.874e-143	478.0	COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1TPMS@1239|Firmicutes,4H3AN@909932|Negativicutes	909932|Negativicutes	NT	Chemotaxis protein CheA	cheA	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,P2
REGS2_k127_2856742_17	1120985.AUMI01000015_gene1671	1.075e-44	169.0	COG1776@1|root,COG1776@2|Bacteria,1UNKB@1239|Firmicutes,4H25I@909932|Negativicutes	909932|Negativicutes	NT	Chemotaxis protein CheC	cheC	-	-	ko:K03410	ko02030,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheC
REGS2_k127_2856742_22	498761.HM1_1954	9.558e-33	133.0	COG1871@1|root,COG1871@2|Bacteria,1V70X@1239|Firmicutes,24HH7@186801|Clostridia	186801|Clostridia	NT	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis	cheD	-	3.5.1.44	ko:K03411	ko02030,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheD
REGS2_k127_2856742_14	635013.TherJR_2805	1.94e-49	195.0	COG2199@1|root,COG2203@1|root,COG2203@2|Bacteria,COG3706@2|Bacteria,1TQIK@1239|Firmicutes,249Y6@186801|Clostridia,267E8@186807|Peptococcaceae	186801|Clostridia	T	TIGRFAM Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,GGDEF
REGS2_k127_2856742_12	502558.EGYY_22240	9.04e-54	201.0	COG3409@1|root,COG3409@2|Bacteria,2HUI4@201174|Actinobacteria,4CUSS@84998|Coriobacteriia	84998|Coriobacteriia	M	Peptidoglycan binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1
REGS2_k127_2856742_19	1463841.JOIR01000010_gene4447	4.778e-40	163.0	COG0791@1|root,COG0791@2|Bacteria,2GIWB@201174|Actinobacteria	201174|Actinobacteria	M	PFAM NLP P60 protein	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	NLPC_P60
REGS2_k127_2856742_3	351607.Acel_0550	2.031e-120	396.0	COG2805@1|root,COG2805@2|Bacteria,2HPWY@201174|Actinobacteria,4EUA1@85013|Frankiales	201174|Actinobacteria	NU	Type II/IV secretion system protein	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
REGS2_k127_2856742_26	1121866.AUGK01000003_gene1233	5.493e-17	85.0	COG5652@1|root,COG5652@2|Bacteria,2HV7C@201174|Actinobacteria,4CWFN@84998|Coriobacteriia	84998|Coriobacteriia	S	VanZ like family	-	-	-	-	-	-	-	-	-	-	-	-	VanZ
REGS2_k127_2856742_28	446468.Ndas_2037	2.731e-06	59.0	COG0697@1|root,COG0697@2|Bacteria,2GKVT@201174|Actinobacteria,4EIZY@85012|Streptosporangiales	201174|Actinobacteria	EG	EamA-like transporter family	ydeD	-	-	-	-	-	-	-	-	-	-	-	EamA
REGS2_k127_2856742_2	266117.Rxyl_2308	3.907e-128	434.0	COG0744@1|root,COG0744@2|Bacteria,2GK21@201174|Actinobacteria,4CPUU@84995|Rubrobacteria	84995|Rubrobacteria	M	glycosyl transferase, family 51	-	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
REGS2_k127_2856742_6	697281.Mahau_2307	9.371e-88	304.0	COG1145@1|root,COG2006@1|root,COG1145@2|Bacteria,COG2006@2|Bacteria,1TRX2@1239|Firmicutes,249GX@186801|Clostridia,42F8W@68295|Thermoanaerobacterales	186801|Clostridia	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF362,Fer4,Fer4_10,Fer4_7
REGS2_k127_2856742_8	351607.Acel_1872	4.501e-63	231.0	COG0840@1|root,COG0840@2|Bacteria,2IA80@201174|Actinobacteria	201174|Actinobacteria	NT	chemotaxis	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CHASE3,MCPsignal
REGS2_k127_2856742_20	1043493.BBLU01000017_gene1376	5.067e-39	154.0	COG0251@1|root,COG0251@2|Bacteria,2IHNE@201174|Actinobacteria	201174|Actinobacteria	J	endoribonuclease L-PSP	yabJ	-	-	-	-	-	-	-	-	-	-	-	YjgF_endoribonc
REGS2_k127_2856742_5	1120973.AQXL01000121_gene68	5.03e-104	354.0	COG0477@1|root,COG2814@2|Bacteria,1TPPY@1239|Firmicutes,4HNJ9@91061|Bacilli,27A8T@186823|Alicyclobacillaceae	91061|Bacilli	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
REGS2_k127_2856742_23	635013.TherJR_1118	2.871e-28	132.0	COG3005@1|root,COG3005@2|Bacteria,1VBE7@1239|Firmicutes,24YVE@186801|Clostridia,2672I@186807|Peptococcaceae	186801|Clostridia	C	NapC/NirT cytochrome c family, N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_NNT
REGS2_k127_2856742_27	1125863.JAFN01000001_gene3133	8.929e-15	88.0	COG3303@1|root,COG3303@2|Bacteria,1MYBV@1224|Proteobacteria,42SER@68525|delta/epsilon subdivisions,2WPC2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C7
REGS2_k127_2856742_25	485913.Krac_6737	1.397e-22	107.0	2E3IJ@1|root,32YH0@2|Bacteria,2G7AM@200795|Chloroflexi	200795|Chloroflexi	S	Predicted membrane protein (DUF2085)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2085
REGS2_k127_2856742_13	933262.AXAM01000025_gene3411	1.079e-49	192.0	COG3481@1|root,COG3481@2|Bacteria,1NH0C@1224|Proteobacteria,42Q7X@68525|delta/epsilon subdivisions,2WJW2@28221|Deltaproteobacteria,2MICY@213118|Desulfobacterales	28221|Deltaproteobacteria	S	nucleic acid binding OB-fold tRNA helicase-type	yhaM	-	-	ko:K03698	-	-	-	-	ko00000,ko01000,ko03019	-	-	-	HD,tRNA_anti-codon
REGS2_k127_2856742_4	643648.Slip_0897	1.116e-115	386.0	COG0005@1|root,COG0005@2|Bacteria,1TQ37@1239|Firmicutes,247KQ@186801|Clostridia,42JJA@68298|Syntrophomonadaceae	186801|Clostridia	F	Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage	-	-	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
REGS2_k127_2856742_15	195250.CM001776_gene3489	7.304e-47	185.0	COG0517@1|root,COG1994@1|root,COG0517@2|Bacteria,COG1994@2|Bacteria,1G05Y@1117|Cyanobacteria,1GZIZ@1129|Synechococcus	1117|Cyanobacteria	S	Belongs to the peptidase M50B family	-	-	-	ko:K06402	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	CBS,Peptidase_M50
REGS2_k127_2856742_10	266117.Rxyl_3182	4.509e-55	200.0	COG2344@1|root,COG2344@2|Bacteria,2GMV2@201174|Actinobacteria,4CPVR@84995|Rubrobacteria	84995|Rubrobacteria	K	Modulates transcription in response to changes in cellular NADH NAD( ) redox state	rex	-	-	ko:K01926	-	-	-	-	ko00000,ko03000	-	-	-	CoA_binding,DUF836,Put_DNA-bind_N
REGS2_k127_2856742_16	1121866.AUGK01000019_gene784	2.387e-46	174.0	COG0782@1|root,COG0782@2|Bacteria,2GNZV@201174|Actinobacteria,4CVRE@84998|Coriobacteriia	84998|Coriobacteriia	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	-	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
REGS2_k127_2856742_1	502558.EGYY_07870	2.543e-136	454.0	COG1190@1|root,COG1190@2|Bacteria,2GKE0@201174|Actinobacteria,4CUAX@84998|Coriobacteriia	84998|Coriobacteriia	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon,tRNA_bind
REGS2_k127_2858830_20	243231.GSU1043	3.086e-56	221.0	COG4251@1|root,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,MASE3,PAS_3,PAS_4,PAS_9,dCache_1
REGS2_k127_2858830_29	1169154.KB897784_gene4184	7.028e-35	154.0	COG2203@1|root,COG2208@1|root,COG3290@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,COG3290@2|Bacteria,2GK8P@201174|Actinobacteria	201174|Actinobacteria	T	protein phosphatase 2C domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c_2,PAS,PAS_4,PAS_8,SpoIIE,sCache_3_2
REGS2_k127_2858830_19	697281.Mahau_2272	5.137e-62	229.0	COG2843@1|root,COG2843@2|Bacteria,1UCFI@1239|Firmicutes,25CHR@186801|Clostridia,42F07@68295|Thermoanaerobacterales	186801|Clostridia	M	PFAM Capsule synthesis protein, CapA	capA	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap,Peptidase_M15
REGS2_k127_2858830_11	351160.RCIX1685	2.191e-75	259.0	COG3369@1|root,arCOG03174@2157|Archaea,2XX0Q@28890|Euryarchaeota,2NAIG@224756|Methanomicrobia	224756|Methanomicrobia	S	SMART zinc finger, CDGSH-type domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_19,zf-CDGSH
REGS2_k127_2858830_41	717606.PaecuDRAFT_2426	5.192e-05	53.0	2CKD9@1|root,333BQ@2|Bacteria,1VIGZ@1239|Firmicutes,4HQNF@91061|Bacilli,26RC6@186822|Paenibacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS2_k127_2858830_17	379066.GAU_0229	3.14e-65	238.0	COG0350@1|root,COG2169@1|root,COG0350@2|Bacteria,COG2169@2|Bacteria,1ZTKM@142182|Gemmatimonadetes	142182|Gemmatimonadetes	FL	6-O-methylguanine DNA methyltransferase, DNA binding domain	-	-	2.1.1.63	ko:K10778	-	-	-	-	ko00000,ko01000,ko03000,ko03400	-	-	-	DNA_binding_1,HTH_18
REGS2_k127_2858830_24	1192034.CAP_7227	9.968e-43	169.0	COG1434@1|root,COG1434@2|Bacteria,1NDJM@1224|Proteobacteria,42XJW@68525|delta/epsilon subdivisions,2WSJ3@28221|Deltaproteobacteria,2YVV6@29|Myxococcales	28221|Deltaproteobacteria	S	DUF218 domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF218
REGS2_k127_2858830_27	1123242.JH636436_gene355	6.298e-37	147.0	COG2318@1|root,COG2318@2|Bacteria,2J0BN@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF664)	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
REGS2_k127_2858830_4	338966.Ppro_0469	1.754e-148	481.0	COG1013@1|root,COG1013@2|Bacteria,1MUY9@1224|Proteobacteria,42MQY@68525|delta/epsilon subdivisions,2WJGJ@28221|Deltaproteobacteria,43UKU@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	1.2.7.1	ko:K00170	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
REGS2_k127_2858830_3	338966.Ppro_0470	1.328e-178	573.0	COG0674@1|root,COG0674@2|Bacteria,1MVM0@1224|Proteobacteria,42MZ0@68525|delta/epsilon subdivisions,2WJG3@28221|Deltaproteobacteria,43TT3@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Pyruvate:ferredoxin oxidoreductase core domain II	-	-	1.2.7.1	ko:K00169	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
REGS2_k127_2858830_26	338966.Ppro_0471	1.04e-37	148.0	COG1144@1|root,COG1144@2|Bacteria,1NE6F@1224|Proteobacteria,42W4G@68525|delta/epsilon subdivisions,2WS1A@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	oxidoreductase, delta subunit	-	-	1.2.7.1	ko:K00171	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4
REGS2_k127_2858830_12	338966.Ppro_0472	5.705e-75	258.0	COG1014@1|root,COG1014@2|Bacteria,1N0EJ@1224|Proteobacteria,42UN6@68525|delta/epsilon subdivisions,2WQCE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM pyruvate ferredoxin flavodoxin oxidoreductase	-	-	1.2.7.1	ko:K00172	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
REGS2_k127_2858830_0	338966.Ppro_0473	6.953e-299	923.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42M5F@68525|delta/epsilon subdivisions,2WJ1T@28221|Deltaproteobacteria,43S9K@69541|Desulfuromonadales	28221|Deltaproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
REGS2_k127_2858830_10	338966.Ppro_0474	6.763e-76	258.0	COG1813@1|root,COG3837@1|root,COG1813@2|Bacteria,COG3837@2|Bacteria	2|Bacteria	S	Cupin domain	-	-	-	ko:K15546	-	-	-	-	ko00000,ko03000	-	-	-	Cupin_2,HTH_19,HTH_3,HTH_31,SKI
REGS2_k127_2858830_8	192952.MM_0519	3.705e-78	282.0	arCOG12964@1|root,arCOG12964@2157|Archaea,2Y2FZ@28890|Euryarchaeota	28890|Euryarchaeota	S	Tocopherol cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Tocopherol_cycl
REGS2_k127_2858830_22	661087.HMPREF1008_01005	5.856e-45	167.0	COG1671@1|root,COG1671@2|Bacteria,2HT7E@201174|Actinobacteria,4CVRN@84998|Coriobacteriia	84998|Coriobacteriia	J	Belongs to the UPF0178 family	-	-	-	ko:K09768	-	-	-	-	ko00000	-	-	-	2_5_RNA_ligase2,DUF188
REGS2_k127_2858830_38	1507.HMPREF0262_02249	2.947e-16	85.0	2C9IH@1|root,32RPC@2|Bacteria,1VBJ7@1239|Firmicutes,24NU4@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS2_k127_2858830_40	1313172.YM304_02450	1.733e-07	59.0	2DH1Q@1|root,2ZY32@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF2510)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2510
REGS2_k127_2858830_36	552811.Dehly_1134	9.254e-20	99.0	COG5012@1|root,COG5012@2|Bacteria,2G6R8@200795|Chloroflexi	200795|Chloroflexi	K	PFAM regulatory protein, MerR	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,B12-binding_2,MerR_1
REGS2_k127_2858830_16	573061.Clocel_0638	4.556e-67	242.0	COG4591@1|root,COG4591@2|Bacteria,1TQ8J@1239|Firmicutes,24BJ2@186801|Clostridia,36ETG@31979|Clostridiaceae	186801|Clostridia	M	ABC-type transport system, involved in lipoprotein release, permease component	-	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
REGS2_k127_2858830_14	1280689.AUJC01000005_gene684	1.456e-69	243.0	COG1136@1|root,COG1136@2|Bacteria,1TP6H@1239|Firmicutes,247JJ@186801|Clostridia,36ES4@31979|Clostridiaceae	186801|Clostridia	V	Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner	lolD	-	-	ko:K09810	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.125	-	-	ABC_tran
REGS2_k127_2858830_15	404380.Gbem_2197	1.679e-67	241.0	COG1801@1|root,COG1801@2|Bacteria,1N06I@1224|Proteobacteria,43BIA@68525|delta/epsilon subdivisions,2X6WP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
REGS2_k127_2858830_23	497964.CfE428DRAFT_0993	5.455e-43	163.0	COG1247@1|root,COG1247@2|Bacteria,46T83@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Acetyltransferase (GNAT) domain	-	-	2.3.1.183	ko:K03823	ko00440,ko01130,map00440,map01130	-	R08871,R08938	RC00004,RC00064	ko00000,ko00001,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_4
REGS2_k127_2858830_6	1089553.Tph_c23660	6.859e-80	295.0	COG0577@1|root,COG0577@2|Bacteria,1TPHU@1239|Firmicutes,248RV@186801|Clostridia,42J1N@68295|Thermoanaerobacterales	186801|Clostridia	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
REGS2_k127_2858830_18	1487953.JMKF01000053_gene1912	2.061e-62	222.0	COG1136@1|root,COG1136@2|Bacteria,1G4GN@1117|Cyanobacteria,1HH6B@1150|Oscillatoriales	1117|Cyanobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003,ko:K09810	ko02010,map02010	M00255,M00258	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.125	-	-	ABC_tran
REGS2_k127_2858830_33	1122927.KB895418_gene2863	3.061e-26	116.0	COG1309@1|root,COG1309@2|Bacteria,1TPXF@1239|Firmicutes,4I43R@91061|Bacilli,26YJ3@186822|Paenibacillaceae	91061|Bacilli	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
REGS2_k127_2858830_25	1423321.AS29_14535	3.801e-40	155.0	COG3476@1|root,COG3476@2|Bacteria,1V3N3@1239|Firmicutes,4HHUN@91061|Bacilli	91061|Bacilli	T	TspO/MBR family	-	-	-	ko:K05770	ko04080,ko04214,ko04979,ko05166,map04080,map04214,map04979,map05166	-	-	-	ko00000,ko00001,ko02000	9.A.24	-	-	TspO_MBR
REGS2_k127_2858830_28	251229.Chro_5101	1.542e-36	148.0	COG1668@1|root,COG1668@2|Bacteria	2|Bacteria	CP	transmembrane transport	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
REGS2_k127_2858830_5	251229.Chro_2593	2.722e-99	352.0	COG1131@1|root,COG1131@2|Bacteria,1GDU7@1117|Cyanobacteria	1117|Cyanobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
REGS2_k127_2858830_9	515635.Dtur_1622	6.799e-78	289.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	recX	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006629,GO:0006643,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016740,GO:0016757,GO:0016758,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0046872,GO:0071704,GO:1901576	2.4.1.337	ko:K19002	ko00561,ko01100,map00561,map01100	-	R10850	RC00005,RC00059	ko00000,ko00001,ko01000,ko01003	-	GT4	-	Glyco_transf_4,Glycos_transf_1,RecX
REGS2_k127_2858830_1	1123242.JH636435_gene1911	1.411e-242	769.0	COG0210@1|root,COG0210@2|Bacteria,2IY8S@203682|Planctomycetes	203682|Planctomycetes	L	UvrD-like helicase C-terminal domain	-	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
REGS2_k127_2858830_39	479434.Sthe_1748	5.617e-09	64.0	COG3063@1|root,COG3063@2|Bacteria,2G79Z@200795|Chloroflexi,27YJ3@189775|Thermomicrobia	189775|Thermomicrobia	NU	Type IV pilus biogenesis stability protein PilW	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS2_k127_2858830_7	909663.KI867150_gene1799	2.485e-78	269.0	COG1933@1|root,COG1933@2|Bacteria,1R1YB@1224|Proteobacteria	1224|Proteobacteria	L	Double zinc ribbon	-	-	-	-	-	-	-	-	-	-	-	-	DZR
REGS2_k127_2858830_21	445335.CBN_2184	2.764e-55	200.0	COG3764@1|root,COG3764@2|Bacteria,1V1RS@1239|Firmicutes,25M25@186801|Clostridia,36MJA@31979|Clostridiaceae	186801|Clostridia	M	Sortase family	-	-	3.4.22.70	ko:K07284	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Sortase
REGS2_k127_2858830_13	1463887.KL590016_gene6323	2.195e-74	264.0	COG4932@1|root,COG4932@2|Bacteria,2GJ4T@201174|Actinobacteria	201174|Actinobacteria	M	Protein of unknown function (DUF3494)	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_5,DUF3494
REGS2_k127_2858830_34	67352.JODS01000003_gene1880	3.573e-26	124.0	COG0791@1|root,COG3409@1|root,COG0791@2|Bacteria,COG3409@2|Bacteria,2I61A@201174|Actinobacteria	201174|Actinobacteria	M	Peptidoglycan-binding domain 1 protein	-	-	-	-	-	-	-	-	-	-	-	-	NLPC_P60,PG_binding_1
REGS2_k127_2858830_31	1121028.ARQE01000012_gene412	1.296e-31	141.0	COG0265@1|root,COG0265@2|Bacteria	2|Bacteria	O	serine-type endopeptidase activity	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	Beta_helix,CBM_6,DUF1565,PDZ_2,Trypsin_2
REGS2_k127_2858830_32	903814.ELI_1157	3.805e-30	124.0	2D5AS@1|root,32TIN@2|Bacteria,1VA4E@1239|Firmicutes,24JJQ@186801|Clostridia,25X4H@186806|Eubacteriaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_B561
REGS2_k127_2858830_2	56780.SYN_00748	5.412e-209	674.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,42NTV@68525|delta/epsilon subdivisions,2WJTP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM CoA-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
REGS2_k127_2858830_35	525904.Tter_0567	1.91e-25	115.0	COG3103@1|root,COG3764@1|root,COG3103@2|Bacteria,COG3764@2|Bacteria	2|Bacteria	M	Sortase family	ylcC	-	3.4.22.70,3.5.1.104	ko:K07284,ko:K22278	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Sortase
REGS2_k127_2858830_30	1303692.SFUL_3249	4.15e-32	130.0	COG4932@1|root,COG4932@2|Bacteria,2GJ4T@201174|Actinobacteria	201174|Actinobacteria	M	Protein of unknown function (DUF3494)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3494
REGS2_k127_2859590_8	868131.MSWAN_2227	8.66e-38	146.0	COG2146@1|root,arCOG02852@2157|Archaea,2XUZH@28890|Euryarchaeota	28890|Euryarchaeota	P	COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases	-	-	-	-	-	-	-	-	-	-	-	-	Rieske,Rieske_2
REGS2_k127_2859590_4	326424.FRAAL1628	3.128e-61	222.0	COG0745@1|root,COG0745@2|Bacteria,2GK5S@201174|Actinobacteria,4EUES@85013|Frankiales	201174|Actinobacteria	T	response regulator	resD	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
REGS2_k127_2859590_7	926569.ANT_07890	1.153e-44	185.0	COG2770@1|root,COG5002@1|root,COG2770@2|Bacteria,COG5002@2|Bacteria,2G60Q@200795|Chloroflexi	200795|Chloroflexi	T	histidine kinase HAMP region domain protein	-	-	2.7.13.3	ko:K07642	ko02020,map02020	M00450,M00645,M00646,M00648	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
REGS2_k127_2859590_6	443143.GM18_3375	3.297e-56	214.0	COG2206@1|root,COG2206@2|Bacteria,1MW7F@1224|Proteobacteria,42PHB@68525|delta/epsilon subdivisions,2WMJX@28221|Deltaproteobacteria,43S0A@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	PFAM metal-dependent phosphohydrolase HD sub domain	-	-	-	-	-	-	-	-	-	-	-	-	HD,HD_5,KOW
REGS2_k127_2859590_13	1123376.AUIU01000017_gene138	1.276e-07	60.0	COG2856@1|root,COG2856@2|Bacteria	2|Bacteria	E	Zn peptidase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,Peptidase_M78
REGS2_k127_2859590_5	370438.PTH_2734	3.451e-58	214.0	COG1940@1|root,COG1940@2|Bacteria,1TPKW@1239|Firmicutes,248U9@186801|Clostridia,260S2@186807|Peptococcaceae	186801|Clostridia	GK	pfam rok	glcK	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS10220	ROK
REGS2_k127_2859590_1	370438.PTH_2121	1.616e-129	428.0	COG2768@1|root,COG2768@2|Bacteria,1TQAW@1239|Firmicutes,247IS@186801|Clostridia,260GA@186807|Peptococcaceae	186801|Clostridia	C	Domain of unknown function (DUF362)	-	-	-	ko:K07138	-	-	-	-	ko00000	-	-	-	DUF362,Fer4,Fer4_6
REGS2_k127_2859590_3	913865.DOT_6053	4.55e-71	250.0	COG0313@1|root,COG0313@2|Bacteria,1TP6U@1239|Firmicutes,24864@186801|Clostridia,260K0@186807|Peptococcaceae	186801|Clostridia	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	-	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
REGS2_k127_2859590_12	1042163.BRLA_c033230	3.204e-21	97.0	COG2002@1|root,COG2002@2|Bacteria,1VVY7@1239|Firmicutes,4HWU7@91061|Bacilli,26X0C@186822|Paenibacillaceae	91061|Bacilli	K	Regulators of stationary sporulation gene expression	abrB7	-	-	ko:K06284	-	-	-	-	ko00000,ko03000	-	-	-	HTH_24,MazE_antitoxin,Sigma70_r4
REGS2_k127_2859590_0	429009.Adeg_2115	1.678e-176	568.0	COG0143@1|root,COG0143@2|Bacteria,1TPA1@1239|Firmicutes,248AU@186801|Clostridia,42EPT@68295|Thermoanaerobacterales	186801|Clostridia	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
REGS2_k127_2859590_2	1384484.AEQU_0537	1.151e-71	251.0	COG0084@1|root,COG0084@2|Bacteria,2GMJJ@201174|Actinobacteria,4CVB7@84998|Coriobacteriia	84998|Coriobacteriia	L	Hydrolase, TatD family	-	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
REGS2_k127_2859590_10	552811.Dehly_1300	1.524e-31	131.0	COG0655@1|root,COG0655@2|Bacteria,2GAKP@200795|Chloroflexi,34CPA@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Flavodoxin-like fold	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
REGS2_k127_2859590_9	429009.Adeg_2112	6.379e-36	151.0	COG3583@1|root,COG3584@1|root,COG3583@2|Bacteria,COG3584@2|Bacteria,1TTIK@1239|Firmicutes,24997@186801|Clostridia,42ETJ@68295|Thermoanaerobacterales	186801|Clostridia	S	G5 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	3D,DUF348,G5
REGS2_k127_2859590_11	649764.HMPREF0762_00786	5.847e-22	97.0	COG0030@1|root,COG0030@2|Bacteria,2GKBT@201174|Actinobacteria,4CUIM@84998|Coriobacteriia	84998|Coriobacteriia	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
REGS2_k127_2938282_6	497964.CfE428DRAFT_0305	4.986e-09	67.0	2DP87@1|root,330Z8@2|Bacteria	497964.CfE428DRAFT_0305|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS2_k127_2938282_7	404589.Anae109_1829	2.183e-06	59.0	COG2374@1|root,COG2374@2|Bacteria,1RA34@1224|Proteobacteria,42XZM@68525|delta/epsilon subdivisions,2WT9C@28221|Deltaproteobacteria	1224|Proteobacteria	S	Protein of unknown function (DUF3616)	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS2_k127_2938282_3	889378.Spiaf_0479	4.728e-32	134.0	COG1670@1|root,COG1670@2|Bacteria,2J660@203691|Spirochaetes	203691|Spirochaetes	J	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
REGS2_k127_2938282_1	941449.dsx2_0037	9.551e-201	635.0	COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,42M7A@68525|delta/epsilon subdivisions,2WJ8P@28221|Deltaproteobacteria,2M8XA@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	PFAM glutamine synthetase catalytic region	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
REGS2_k127_2938282_2	479437.Elen_2015	2.674e-55	204.0	COG0745@1|root,COG0745@2|Bacteria,2GJGU@201174|Actinobacteria,4CUTE@84998|Coriobacteriia	84998|Coriobacteriia	K	Transcriptional regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Trans_reg_C
REGS2_k127_2938282_5	416348.Hlac_1953	3.305e-21	103.0	COG0500@1|root,arCOG01773@2157|Archaea,2XY2G@28890|Euryarchaeota,23WHE@183963|Halobacteria	183963|Halobacteria	Q	COG0500 SAM-dependent methyltransferases	-	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11
REGS2_k127_2938282_0	742818.HMPREF9451_01018	2.21e-258	830.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,2GJY2@201174|Actinobacteria,4CUSF@84998|Coriobacteriia	84998|Coriobacteriia	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A
REGS2_k127_2938282_4	1157640.AQWO01000010_gene2792	1.422e-23	108.0	COG0745@1|root,COG0745@2|Bacteria,2GJE6@201174|Actinobacteria	201174|Actinobacteria	T	Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
REGS2_k127_2960367_6	744872.Spica_0350	1.094e-05	48.0	COG2336@1|root,COG2336@2|Bacteria,2JB20@203691|Spirochaetes	203691|Spirochaetes	T	PFAM SpoVT AbrB	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS2_k127_2960367_5	585501.HMPREF6123_2637	6.491e-08	61.0	2DRA2@1|root,33AVQ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS2_k127_2960367_4	305700.B447_12022	1.378e-23	118.0	2ETVI@1|root,33MCS@2|Bacteria,1PUAN@1224|Proteobacteria,2W09P@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS2_k127_2960367_3	205922.Pfl01_3728	2.017e-46	174.0	COG0454@1|root,COG0454@2|Bacteria,1QWJ5@1224|Proteobacteria,1T34G@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_7
REGS2_k127_2960367_0	871963.Desdi_0470	3.807e-226	712.0	COG0747@1|root,COG0747@2|Bacteria,1TQ6S@1239|Firmicutes,248A3@186801|Clostridia,26187@186807|Peptococcaceae	186801|Clostridia	E	PFAM Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
REGS2_k127_2960367_1	1487923.DP73_18890	4.488e-150	481.0	COG0601@1|root,COG0601@2|Bacteria,1TP1S@1239|Firmicutes,247IP@186801|Clostridia,260KR@186807|Peptococcaceae	186801|Clostridia	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
REGS2_k127_2960367_2	1120746.CCNL01000017_gene2438	2.793e-81	279.0	COG1173@1|root,COG1173@2|Bacteria,2NQ14@2323|unclassified Bacteria	2|Bacteria	EP	PFAM binding-protein-dependent transport systems inner membrane component	dppC	-	-	ko:K02034,ko:K12370,ko:K15582	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00324,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1,OppC_N
REGS2_k127_2968566_14	1123517.JOMR01000001_gene1899	1.133e-25	111.0	COG1765@1|root,COG1765@2|Bacteria,1RCZW@1224|Proteobacteria,1S3XF@1236|Gammaproteobacteria,460SJ@72273|Thiotrichales	72273|Thiotrichales	O	PFAM OsmC-like protein	-	-	-	ko:K07397	-	-	-	-	ko00000	-	-	-	OsmC
REGS2_k127_2968566_8	530564.Psta_0549	9.321e-58	214.0	COG0463@1|root,COG0463@2|Bacteria,2J521@203682|Planctomycetes	203682|Planctomycetes	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
REGS2_k127_2968566_6	237368.SCABRO_02159	1.657e-59	217.0	COG2120@1|root,COG2120@2|Bacteria,2IZ0B@203682|Planctomycetes	203682|Planctomycetes	S	GlcNAc-PI de-N-acetylase	-	-	-	ko:K01463	-	-	-	-	ko00000,ko01000	-	-	-	PIG-L
REGS2_k127_2968566_10	1210884.HG799462_gene8507	8.89e-49	193.0	2C7TA@1|root,2Z9TR@2|Bacteria,2IXIJ@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS2_k127_2968566_16	589924.Ferp_1544	2.774e-15	79.0	COG1146@1|root,arCOG00959@2157|Archaea,2XZV5@28890|Euryarchaeota,246G0@183980|Archaeoglobi	183980|Archaeoglobi	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
REGS2_k127_2968566_15	232348.ADXL01000079_gene982	9.178e-20	102.0	COG0344@1|root,COG0344@2|Bacteria,1G3HV@1117|Cyanobacteria,1GYXY@1129|Synechococcus	1117|Cyanobacteria	I	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP	plsY	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
REGS2_k127_2968566_9	479437.Elen_2187	3.144e-55	206.0	COG1597@1|root,COG1597@2|Bacteria,2GK3P@201174|Actinobacteria,4CV1Y@84998|Coriobacteriia	84998|Coriobacteriia	I	lipid kinase, YegS Rv2252 BmrU family	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
REGS2_k127_2968566_12	760568.Desku_1009	6.755e-43	170.0	COG1853@1|root,COG1853@2|Bacteria,1V1EA@1239|Firmicutes,24FWS@186801|Clostridia,2620R@186807|Peptococcaceae	186801|Clostridia	S	DIM6 NTAB family	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
REGS2_k127_2968566_0	502558.EGYY_21920	2.897e-174	557.0	COG0480@1|root,COG0480@2|Bacteria,2GKRU@201174|Actinobacteria,4CUIA@84998|Coriobacteriia	84998|Coriobacteriia	J	elongation factor G	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
REGS2_k127_2968566_4	742818.HMPREF9451_00029	2.907e-74	264.0	COG0480@1|root,COG0480@2|Bacteria,2GKRU@201174|Actinobacteria,4CUIA@84998|Coriobacteriia	84998|Coriobacteriia	J	elongation factor G	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
REGS2_k127_2968566_13	661478.OP10G_0925	1.316e-32	148.0	COG0652@1|root,COG0652@2|Bacteria	2|Bacteria	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	ppiA	-	5.2.1.8	ko:K01802,ko:K03767,ko:K03768	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Pro_isomerase
REGS2_k127_2968566_11	742742.HMPREF9452_00180	1.773e-44	184.0	COG0457@1|root,COG0457@2|Bacteria,2HUGG@201174|Actinobacteria,4CUIP@84998|Coriobacteriia	84998|Coriobacteriia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_12,TPR_16,TPR_6,TPR_7,TPR_8
REGS2_k127_2968566_7	1121866.AUGK01000011_gene543	3.111e-58	205.0	COG0105@1|root,COG0105@2|Bacteria,2IFBU@201174|Actinobacteria,4CVPI@84998|Coriobacteriia	84998|Coriobacteriia	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	-	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
REGS2_k127_2968566_2	742818.HMPREF9451_01061	1.945e-104	349.0	COG0479@1|root,COG0479@2|Bacteria,2I37A@201174|Actinobacteria,4CUEB@84998|Coriobacteriia	84998|Coriobacteriia	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_22
REGS2_k127_2968566_1	1034345.CAEM01000023_gene834	2.361e-143	458.0	COG0543@1|root,COG0543@2|Bacteria,2HXFY@201174|Actinobacteria,4CV8F@84998|Coriobacteriia	84998|Coriobacteriia	C	Oxidoreductase NAD-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
REGS2_k127_2968566_5	479437.Elen_1255	5.611e-73	253.0	COG1941@1|root,COG1941@2|Bacteria,2GSPN@201174|Actinobacteria,4CUTN@84998|Coriobacteriia	84998|Coriobacteriia	C	NADH ubiquinone oxidoreductase, 20 Kd subunit	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_q6
REGS2_k127_2968566_3	479437.Elen_1256	1.696e-80	291.0	COG3259@1|root,COG3259@2|Bacteria,2GQ33@201174|Actinobacteria,4CVBM@84998|Coriobacteriia	84998|Coriobacteriia	C	Nickel-dependent hydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	NiFeSe_Hases
REGS2_k127_3026863_0	1499967.BAYZ01000069_gene1853	1.53e-321	1006.0	COG0474@1|root,COG0474@2|Bacteria,2NNSC@2323|unclassified Bacteria	2|Bacteria	P	Cation transporter/ATPase, N-terminus	pacL	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
REGS2_k127_3026863_8	621372.ACIH01000057_gene1189	0.0006045	51.0	COG1470@1|root,COG1470@2|Bacteria,1VMQY@1239|Firmicutes,4HSBN@91061|Bacilli,277E2@186822|Paenibacillaceae	91061|Bacilli	S	cell adhesion involved in biofilm formation	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS2_k127_3026863_7	1001240.GY21_04095	0.0002017	53.0	COG0681@1|root,COG0681@2|Bacteria,2GYSY@201174|Actinobacteria	201174|Actinobacteria	U	Belongs to the peptidase S26 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S24
REGS2_k127_3026863_2	479437.Elen_2361	6.139e-147	473.0	COG0016@1|root,COG0016@2|Bacteria,2GJGG@201174|Actinobacteria,4CUGV@84998|Coriobacteriia	84998|Coriobacteriia	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
REGS2_k127_3026863_1	742818.HMPREF9451_00261	5.431e-258	818.0	COG0072@1|root,COG0072@2|Bacteria,2GMFD@201174|Actinobacteria,4CUQ6@84998|Coriobacteriia	84998|Coriobacteriia	J	Phenylalanyl-tRNA synthetase, beta subunit	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
REGS2_k127_3026863_5	1121468.AUBR01000019_gene2618	5.497e-100	338.0	COG0002@1|root,COG0002@2|Bacteria,1TPVI@1239|Firmicutes,247R3@186801|Clostridia,42F2M@68295|Thermoanaerobacterales	186801|Clostridia	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	-	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
REGS2_k127_3026863_3	1121428.DESHY_150083___1	2.93e-113	389.0	COG1364@1|root,COG1364@2|Bacteria,1TPBP@1239|Firmicutes,2497Q@186801|Clostridia,26184@186807|Peptococcaceae	186801|Clostridia	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	argJ	-	2.3.1.1,2.3.1.35	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgJ
REGS2_k127_3026863_6	1121866.AUGK01000019_gene765	4.767e-95	320.0	COG0548@1|root,COG0548@2|Bacteria,2GKDS@201174|Actinobacteria,4CUQV@84998|Coriobacteriia	84998|Coriobacteriia	E	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	-	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
REGS2_k127_3026863_4	1121472.AQWN01000001_gene260	2.045e-107	366.0	COG4992@1|root,COG4992@2|Bacteria,1TP9S@1239|Firmicutes,248C9@186801|Clostridia,2606U@186807|Peptococcaceae	186801|Clostridia	E	PFAM Aminotransferase class-III	argD	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
REGS2_k127_3138938_28	471855.Shel_09720	7.812e-39	149.0	COG0240@1|root,COG0240@2|Bacteria,2GJSD@201174|Actinobacteria,4CV3K@84998|Coriobacteriia	84998|Coriobacteriia	I	Glycerol-3-phosphate dehydrogenase	gpsA	-	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
REGS2_k127_3138938_31	481448.Minf_0183	8.18e-28	125.0	COG0344@1|root,COG0344@2|Bacteria,46VTA@74201|Verrucomicrobia,37GTF@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	I	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP	plsY	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
REGS2_k127_3138938_1	1121866.AUGK01000012_gene1789	1.018e-179	572.0	COG1160@1|root,COG1160@2|Bacteria,2GJ8J@201174|Actinobacteria,4CUAJ@84998|Coriobacteriia	84998|Coriobacteriia	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
REGS2_k127_3138938_12	1118060.CAGZ01000024_gene589	1.838e-97	334.0	COG1625@1|root,COG1625@2|Bacteria,2H3RR@201174|Actinobacteria,4CUHT@84998|Coriobacteriia	84998|Coriobacteriia	C	FeS-containing Cyanobacterial-specific oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DUF512
REGS2_k127_3138938_16	521003.COLINT_02435	1.411e-83	299.0	COG0761@1|root,COG0761@2|Bacteria,2GIZ7@201174|Actinobacteria,4CUET@84998|Coriobacteriia	84998|Coriobacteriia	IM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	-	LYTB
REGS2_k127_3138938_29	1123288.SOV_4c04400	3.504e-37	152.0	COG0204@1|root,COG0204@2|Bacteria,1U8N2@1239|Firmicutes,4H4EK@909932|Negativicutes	909932|Negativicutes	I	Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family	plsC	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
REGS2_k127_3138938_23	479437.Elen_1333	5.576e-56	207.0	COG0283@1|root,COG0283@2|Bacteria,2H3SI@201174|Actinobacteria,4CV84@84998|Coriobacteriia	84998|Coriobacteriia	F	Belongs to the cytidylate kinase family. Type 1 subfamily	cmk	-	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyltransferase,Cytidylate_kin
REGS2_k127_3138938_7	1034345.CAEM01000036_gene575	1.53e-119	403.0	COG0128@1|root,COG0128@2|Bacteria,2GJKX@201174|Actinobacteria,4CV1Q@84998|Coriobacteriia	84998|Coriobacteriia	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
REGS2_k127_3138938_14	1034345.CAEM01000036_gene576	4.261e-96	342.0	COG0287@1|root,COG0287@2|Bacteria,2GKB4@201174|Actinobacteria,4CUHA@84998|Coriobacteriia	84998|Coriobacteriia	E	prephenate dehydrogenase	-	-	1.3.1.12	ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025	R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	PDH
REGS2_k127_3138938_6	747365.Thena_0744	1.532e-122	402.0	COG2876@1|root,COG2876@2|Bacteria,1TP61@1239|Firmicutes,24812@186801|Clostridia,42F9V@68295|Thermoanaerobacterales	186801|Clostridia	E	PFAM DAHP synthetase I KDSA	aroF	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
REGS2_k127_3138938_17	1304880.JAGB01000001_gene962	3.573e-83	291.0	COG0079@1|root,COG0079@2|Bacteria,1TPUV@1239|Firmicutes,24837@186801|Clostridia	186801|Clostridia	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
REGS2_k127_3138938_35	1370120.AUWR01000008_gene383	2.858e-18	98.0	COG0328@1|root,COG0406@1|root,COG0328@2|Bacteria,COG0406@2|Bacteria,2GJ9R@201174|Actinobacteria,234GG@1762|Mycobacteriaceae	201174|Actinobacteria	GL	Ribonuclease	rnhA	GO:0003674,GO:0003676,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005488,GO:0006139,GO:0006401,GO:0006725,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016070,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016891,GO:0016893,GO:0017144,GO:0018130,GO:0019438,GO:0019439,GO:0032296,GO:0033013,GO:0033014,GO:0034641,GO:0034655,GO:0042364,GO:0042578,GO:0043170,GO:0043755,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0046700,GO:0051186,GO:0051188,GO:0071667,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576	3.1.26.4,3.1.3.73	ko:K02226,ko:K22316	ko00860,ko01100,ko03030,map00860,map01100,map03030	M00122	R04594,R11173	RC00017	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	His_Phos_1,RVT_3
REGS2_k127_3138938_32	1123360.thalar_01216	3.032e-27	122.0	COG0368@1|root,COG0368@2|Bacteria,1RHCC@1224|Proteobacteria,2U97D@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate	cobS	-	2.7.8.26	ko:K02233	ko00860,ko01100,map00860,map01100	M00122	R05223,R11174	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CobS
REGS2_k127_3138938_8	1125863.JAFN01000001_gene3495	4.864e-112	375.0	COG2038@1|root,COG2038@2|Bacteria,1MVAM@1224|Proteobacteria,42M3Z@68525|delta/epsilon subdivisions,2WJIR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB)	cobT	GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008939,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0017144,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042364,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.4.2.21	ko:K00768	ko00860,ko01100,map00860,map01100	M00122	R04148	RC00033,RC00063	ko00000,ko00001,ko00002,ko01000	-	-	-	DBI_PRT
REGS2_k127_3138938_33	1121017.AUFG01000001_gene2916	1.427e-25	121.0	COG2087@1|root,COG2087@2|Bacteria,2GM8Q@201174|Actinobacteria,4FGDE@85021|Intrasporangiaceae	201174|Actinobacteria	H	Cobinamide kinase / cobinamide phosphate guanyltransferase	cobU	-	2.7.1.156,2.7.7.62	ko:K02231	ko00860,ko01100,map00860,map01100	M00122	R05221,R05222,R06558	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	CobU,Lactamase_B_2
REGS2_k127_3138938_20	926690.KE386573_gene2078	5.542e-70	265.0	COG1120@1|root,arCOG00199@2157|Archaea,2XTTV@28890|Euryarchaeota,23SRW@183963|Halobacteria	183963|Halobacteria	E	COG1120 ABC-type cobalamin Fe3 -siderophores transport systems, ATPase components	btuD	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
REGS2_k127_3138938_22	644966.Tmar_1301	2.876e-67	249.0	COG0609@1|root,COG0609@2|Bacteria,1TPX6@1239|Firmicutes,248IS@186801|Clostridia,3WCIT@538999|Clostridiales incertae sedis	186801|Clostridia	P	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily	-	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
REGS2_k127_3138938_24	266117.Rxyl_2468	3.044e-54	208.0	COG0614@1|root,COG0614@2|Bacteria,2I2MI@201174|Actinobacteria	201174|Actinobacteria	P	ABC-type Fe3 -hydroxamate transport system, periplasmic component	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
REGS2_k127_3138938_15	479437.Elen_1330	1.736e-91	311.0	COG1187@1|root,COG1187@2|Bacteria,2GJ4N@201174|Actinobacteria,4CV89@84998|Coriobacteriia	84998|Coriobacteriia	J	Belongs to the pseudouridine synthase RsuA family	-	-	5.4.99.22	ko:K06178	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
REGS2_k127_3138938_21	633147.Olsu_0913	4.535e-68	238.0	COG1386@1|root,COG1386@2|Bacteria,2GISY@201174|Actinobacteria,4CVF5@84998|Coriobacteriia	84998|Coriobacteriia	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves	scpB	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
REGS2_k127_3138938_18	1111121.HMPREF1247_1275	4.653e-79	271.0	COG1354@1|root,COG1354@2|Bacteria,2GN1U@201174|Actinobacteria,4CUNI@84998|Coriobacteriia	84998|Coriobacteriia	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	-	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
REGS2_k127_3138938_10	204669.Acid345_3860	6.411e-103	346.0	COG0180@1|root,COG0180@2|Bacteria,3Y2VN@57723|Acidobacteria,2JHXI@204432|Acidobacteriia	204432|Acidobacteriia	J	aminoacyl-tRNA synthetase	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
REGS2_k127_3138938_26	555779.Dthio_PD1671	8.729e-47	177.0	COG1994@1|root,COG1994@2|Bacteria,1NSFF@1224|Proteobacteria,42STM@68525|delta/epsilon subdivisions,2WPAD@28221|Deltaproteobacteria,2MB8X@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM peptidase M50	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
REGS2_k127_3138938_0	635013.TherJR_1640	6.29e-188	619.0	COG0517@1|root,COG0617@1|root,COG0618@1|root,COG0517@2|Bacteria,COG0617@2|Bacteria,COG0618@2|Bacteria,1TQ2A@1239|Firmicutes,247XC@186801|Clostridia,260EB@186807|Peptococcaceae	186801|Clostridia	J	tRNA nucleotidyltransferase poly(A) polymerase	cca	-	2.7.7.19,2.7.7.72	ko:K00970,ko:K00974	ko03013,ko03018,map03013,map03018	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	CBS,DHH,DHHA1,PolyA_pol,PolyA_pol_RNAbd,tRNA_NucTran2_2
REGS2_k127_3138938_3	1120971.AUCA01000009_gene2006	3.644e-142	463.0	COG0213@1|root,COG0295@1|root,COG0213@2|Bacteria,COG0295@2|Bacteria,1TPCH@1239|Firmicutes,4H9NP@91061|Bacilli,278UM@186823|Alicyclobacillaceae	91061|Bacilli	F	Pyrimidine nucleoside phosphorylase C-terminal domain	pdp	GO:0003674,GO:0003824,GO:0004645,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0009032,GO:0016740,GO:0016757,GO:0016758,GO:0016763,GO:0044424,GO:0044444,GO:0044464	2.4.2.2	ko:K00756	ko00240,ko01100,map00240,map01100	-	R01570,R01876,R02296,R02484	RC00063	ko00000,ko00001,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3,PYNP_C
REGS2_k127_3138938_4	1121430.JMLG01000003_gene532	1.314e-139	454.0	COG1015@1|root,COG1015@2|Bacteria,1TP70@1239|Firmicutes,247WB@186801|Clostridia,260HR@186807|Peptococcaceae	186801|Clostridia	G	Phosphotransfer between the C1 and C5 carbon atoms of pentose	deoB	-	5.4.2.7	ko:K01839	ko00030,ko00230,map00030,map00230	-	R01057,R02749	RC00408	ko00000,ko00001,ko01000	-	-	-	Metalloenzyme
REGS2_k127_3138938_2	351607.Acel_1322	1.384e-150	500.0	COG2804@1|root,COG2804@2|Bacteria,2I8C2@201174|Actinobacteria,4ES0V@85013|Frankiales	201174|Actinobacteria	NU	General secretory system II, protein E domain protein	-	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
REGS2_k127_3138938_27	1449069.JMLO01000014_gene4417	1.115e-41	171.0	COG1007@1|root,COG1007@2|Bacteria,2GMGX@201174|Actinobacteria,4FUIY@85025|Nocardiaceae	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
REGS2_k127_3138938_11	329726.AM1_2126	9.474e-98	342.0	COG1008@1|root,COG1008@2|Bacteria,1G0VB@1117|Cyanobacteria	1117|Cyanobacteria	C	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	ndhD2	-	1.6.5.3	ko:K00342,ko:K05575	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iJN678.ndhD2	Oxidored_q5_N,Proton_antipo_M
REGS2_k127_3138938_5	562970.Btus_3223	7.197e-127	430.0	COG1009@1|root,COG1009@2|Bacteria,1TQW4@1239|Firmicutes,4H9YR@91061|Bacilli,27873@186823|Alicyclobacillaceae	91061|Bacilli	CP	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus	nuoL	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_C,Proton_antipo_M,Proton_antipo_N
REGS2_k127_3138938_37	649639.Bcell_4058	1.998e-11	71.0	COG0713@1|root,COG0713@2|Bacteria,1V9Z8@1239|Firmicutes,4HJ9Q@91061|Bacilli,1ZGXH@1386|Bacillus	91061|Bacilli	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK	GO:0003674,GO:0003824,GO:0003954,GO:0008137,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114	1.6.5.3	ko:K00340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
REGS2_k127_3138938_38	679201.HMPREF9334_01219	6.939e-11	69.0	COG0839@1|root,COG0839@2|Bacteria,1VAQI@1239|Firmicutes,4H4S3@909932|Negativicutes	909932|Negativicutes	C	NADH-ubiquinone plastoquinone oxidoreductase chain 6	nuoJ	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
REGS2_k127_3138938_9	264732.Moth_1194	1.994e-105	378.0	COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,42EUY@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,Fer4_7,NAD_binding_8,Pyr_redox_2
REGS2_k127_3138938_19	264732.Moth_0981	2.907e-74	264.0	COG1005@1|root,COG1005@2|Bacteria,1TQNU@1239|Firmicutes,25E6Z@186801|Clostridia,42FT6@68295|Thermoanaerobacterales	186801|Clostridia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
REGS2_k127_3138938_34	1379698.RBG1_1C00001G0024	1.798e-19	102.0	COG0649@1|root,COG0649@2|Bacteria	2|Bacteria	C	NAD binding	nuoD	GO:0003674,GO:0003824,GO:0003954,GO:0008137,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114	1.6.5.3	ko:K00333,ko:K05579,ko:K13378	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa,Complex1_49kDa
REGS2_k127_3138938_13	498761.HM1_2199	8.542e-97	333.0	COG0649@1|root,COG0649@2|Bacteria,1TQAR@1239|Firmicutes,24EDV@186801|Clostridia	186801|Clostridia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
REGS2_k127_3138938_30	649349.Lbys_0643	1.518e-29	123.0	COG0852@1|root,COG0852@2|Bacteria,4NPGA@976|Bacteroidetes,47PNZ@768503|Cytophagia	976|Bacteroidetes	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
REGS2_k127_3138938_25	717231.Flexsi_0200	1.803e-50	188.0	COG0377@1|root,COG0377@2|Bacteria,2GEU3@200930|Deferribacteres	200930|Deferribacteres	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoB	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
REGS2_k127_3138938_36	1284775.HMPREF1640_10680	5.512e-14	79.0	COG0838@1|root,COG0838@2|Bacteria,4NQET@976|Bacteroidetes,2FTGA@200643|Bacteroidia	976|Bacteroidetes	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoA	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0050136,GO:0055114,GO:0098796,GO:1902494	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
REGS2_k127_3182552_4	1123405.AUMM01000007_gene981	1.052e-47	173.0	COG2873@1|root,COG2873@2|Bacteria,1VYCY@1239|Firmicutes,4H9X5@91061|Bacilli,26NAS@186821|Sporolactobacillaceae	91061|Bacilli	E	Cys/Met metabolism PLP-dependent enzyme	metY	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	CoA_binding_2,Cys_Met_Meta_PP
REGS2_k127_3182552_2	926550.CLDAP_17170	2.192e-125	415.0	COG2021@1|root,COG2021@2|Bacteria,2G5JD@200795|Chloroflexi	200795|Chloroflexi	E	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine	metXA	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004414,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009092,GO:0009987,GO:0016053,GO:0016407,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.31	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	-	R01776	RC00004,RC00041	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
REGS2_k127_3182552_3	1380358.JADJ01000015_gene2305	3.709e-62	222.0	COG4123@1|root,COG4123@2|Bacteria,1QUWW@1224|Proteobacteria,1T24A@1236|Gammaproteobacteria,1XRRX@135619|Oceanospirillales	135619|Oceanospirillales	S	Methionine biosynthesis protein MetW	metW	-	-	-	-	-	-	-	-	-	-	-	MetW
REGS2_k127_3182552_0	518766.Rmar_1535	7.725e-245	776.0	COG2217@1|root,COG2217@2|Bacteria,4NERS@976|Bacteroidetes,1FIZ6@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	P	heavy metal translocating P-type ATPase	copB	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
REGS2_k127_3182552_7	443143.GM18_3953	1.295e-07	57.0	COG3462@1|root,COG3462@2|Bacteria	2|Bacteria	S	membrane protein (DUF2078)	-	-	-	ko:K08982	-	-	-	-	ko00000	-	-	-	SHOCT
REGS2_k127_3182552_5	224325.AF_0190	4.994e-18	91.0	COG2010@1|root,arCOG06111@2157|Archaea,2XXGW@28890|Euryarchaeota,2469C@183980|Archaeoglobi	183980|Archaeoglobi	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	Cytochrom_C,Cytochrome_CBB3
REGS2_k127_3182552_6	1385521.N803_05710	5.678e-08	64.0	COG2335@1|root,COG2335@2|Bacteria	2|Bacteria	M	COG2335, Secreted and surface protein containing fasciclin-like repeats	-	-	-	-	-	-	-	-	-	-	-	-	COP23,Fasciclin
REGS2_k127_3182552_1	1449126.JQKL01000002_gene1616	3.046e-221	704.0	COG2217@1|root,COG2217@2|Bacteria,1TP5S@1239|Firmicutes,247MW@186801|Clostridia,267PD@186813|unclassified Clostridiales	186801|Clostridia	P	Heavy-metal-associated domain	copA	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
REGS2_k127_3280182_15	562743.JH976434_gene1836	5.211e-14	74.0	2DBV7@1|root,2ZB9P@2|Bacteria,1UBN2@1239|Firmicutes,4HEYF@91061|Bacilli	91061|Bacilli	S	Domain of unknown function (DUF4386)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4386
REGS2_k127_3280182_12	1237149.C900_01932	2.216e-29	126.0	2DBV7@1|root,2ZB9P@2|Bacteria,4NPQU@976|Bacteroidetes,47QI9@768503|Cytophagia	976|Bacteroidetes	S	Domain of unknown function (DUF4386)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4386
REGS2_k127_3280182_14	1170562.Cal6303_3974	3.302e-19	101.0	COG0845@1|root,COG0845@2|Bacteria,1G01U@1117|Cyanobacteria,1HM23@1161|Nostocales	1117|Cyanobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
REGS2_k127_3280182_5	292459.STH976	2.573e-80	283.0	COG1136@1|root,COG1136@2|Bacteria,1TPBJ@1239|Firmicutes,248EZ@186801|Clostridia	186801|Clostridia	V	ABC transporter	macB	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
REGS2_k127_3280182_3	1048339.KB913029_gene2313	2.024e-84	294.0	COG0577@1|root,COG0577@2|Bacteria,2GIRW@201174|Actinobacteria,4EUUS@85013|Frankiales	201174|Actinobacteria	V	MacB-like periplasmic core domain	yknZ	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
REGS2_k127_3280182_11	1285586.H131_08088	6.248e-40	162.0	COG1266@1|root,COG1266@2|Bacteria,1VVP0@1239|Firmicutes,4HWDD@91061|Bacilli	91061|Bacilli	S	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
REGS2_k127_3280182_6	1173020.Cha6605_0968	1.8e-75	258.0	COG2267@1|root,COG2267@2|Bacteria,1G771@1117|Cyanobacteria	2|Bacteria	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Hydrolase_4
REGS2_k127_3280182_7	101510.RHA1_ro02950	9.982e-61	217.0	COG1309@1|root,COG1309@2|Bacteria,2GV75@201174|Actinobacteria,4FX2S@85025|Nocardiaceae	201174|Actinobacteria	K	Tetracyclin repressor, C-terminal all-alpha domain	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C,TetR_N
REGS2_k127_3280182_10	765420.OSCT_0070	2.384e-49	186.0	28IZQ@1|root,2Z8X1@2|Bacteria,2GA1E@200795|Chloroflexi,377NY@32061|Chloroflexia	32061|Chloroflexia	S	Domain of unknown function (DUF4386)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4386
REGS2_k127_3280182_2	525897.Dbac_2111	3.529e-86	297.0	COG2199@1|root,COG2199@2|Bacteria,1RGCV@1224|Proteobacteria,42YPK@68525|delta/epsilon subdivisions,2WTVJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	PFAM GGDEF domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,PAS,PAS_3
REGS2_k127_3280182_8	1380347.JNII01000010_gene2592	8.471e-60	209.0	2DK0G@1|root,30823@2|Bacteria,2IJ7K@201174|Actinobacteria	201174|Actinobacteria	S	Rifampin ADP-ribosyl transferase	arr	-	-	ko:K19062	-	-	-	-	ko00000,ko01504	-	-	-	Arr-ms
REGS2_k127_3280182_1	926692.AZYG01000011_gene1122	6.227e-179	583.0	COG0119@1|root,COG0119@2|Bacteria,1TRIK@1239|Firmicutes,249Q4@186801|Clostridia,3WACK@53433|Halanaerobiales	186801|Clostridia	E	Belongs to the alpha-IPM synthase homocitrate synthase family	leuA3	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
REGS2_k127_3280182_4	2325.TKV_c02120	2.452e-81	277.0	COG0179@1|root,COG0179@2|Bacteria,1TQDQ@1239|Firmicutes,248AJ@186801|Clostridia,42F3V@68295|Thermoanaerobacterales	186801|Clostridia	Q	PFAM fumarylacetoacetate (FAA) hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	DUF2437,FAA_hydrolase
REGS2_k127_3280182_9	1229780.BN381_80314	1.637e-53	207.0	COG0477@1|root,COG2814@2|Bacteria,2I2EY@201174|Actinobacteria,3UXSW@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
REGS2_k127_3280182_13	883156.HMPREF9282_01376	1.256e-23	104.0	COG4496@1|root,COG4496@2|Bacteria,1VA04@1239|Firmicutes,4H53N@909932|Negativicutes	909932|Negativicutes	S	TrpR family protein YerC YecD	-	-	-	-	-	-	-	-	-	-	-	-	Trp_repressor
REGS2_k127_3280182_0	469378.Ccur_12030	0.0	1121.0	COG0587@1|root,COG0587@2|Bacteria,2GJ1P@201174|Actinobacteria,4CV21@84998|Coriobacteriia	84998|Coriobacteriia	L	DNA polymerase III alpha subunit	-	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
REGS2_k127_3280182_16	742818.HMPREF9451_00436	0.00012	49.0	COG0040@1|root,COG3705@1|root,COG0040@2|Bacteria,COG3705@2|Bacteria,2GNAX@201174|Actinobacteria,4CUNG@84998|Coriobacteriia	84998|Coriobacteriia	E	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity	hisG	-	2.4.2.17	ko:K00765,ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG,tRNA-synt_His
REGS2_k127_3317187_0	649764.HMPREF0762_00372	7.953e-85	290.0	COG1227@1|root,COG2524@1|root,COG1227@2|Bacteria,COG2524@2|Bacteria,2IG04@201174|Actinobacteria,4CV63@84998|Coriobacteriia	84998|Coriobacteriia	CK	domain protein	-	-	3.6.1.1	ko:K15986	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	CBS,DHH,DHHA2,DRTGG
REGS2_k127_3317187_4	766499.C357_09652	1.046e-17	94.0	COG0671@1|root,COG0671@2|Bacteria,1RDK3@1224|Proteobacteria,2U7BJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	PFAM phosphoesterase, PA-phosphatase related	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
REGS2_k127_3317187_2	1125863.JAFN01000001_gene2108	6.904e-67	252.0	COG5002@1|root,COG5002@2|Bacteria,1MWF3@1224|Proteobacteria,42NB5@68525|delta/epsilon subdivisions,2WJGX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	histidine kinase HAMP region domain protein	phoR	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_8,sCache_like
REGS2_k127_3317187_1	42256.RradSPS_2422	1.76e-67	238.0	COG0745@1|root,COG0745@2|Bacteria,2GKFS@201174|Actinobacteria,4CU2Q@84995|Rubrobacteria	201174|Actinobacteria	K	Response regulator receiver	regX3	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009405,GO:0009889,GO:0010468,GO:0010556,GO:0010565,GO:0019216,GO:0019217,GO:0019219,GO:0019220,GO:0019222,GO:0031323,GO:0031326,GO:0044419,GO:0048583,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051252,GO:0051704,GO:0060255,GO:0062012,GO:0065007,GO:0080090,GO:0080134,GO:0097159,GO:1901363,GO:1902882,GO:1903506,GO:2000112,GO:2001141	-	ko:K07776	ko02020,map02020	M00443	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
REGS2_k127_3317187_3	1408422.JHYF01000006_gene1210	3.312e-63	237.0	COG0226@1|root,COG0226@2|Bacteria,1TQ5X@1239|Firmicutes,248QU@186801|Clostridia,36F61@31979|Clostridiaceae	186801|Clostridia	P	TIGRFAM phosphate binding protein	-	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like,PBP_like_2
REGS2_k127_3349994_19	1118058.CAGY01000003_gene904	3.887e-14	72.0	COG0230@1|root,COG0230@2|Bacteria,2GQFY@201174|Actinobacteria,4D6Q0@85005|Actinomycetales	201174|Actinobacteria	J	Belongs to the bacterial ribosomal protein bL34 family	rpmH	-	-	ko:K02914	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L34
REGS2_k127_3349994_17	445975.COLSTE_02210	1.612e-17	86.0	COG0594@1|root,COG0594@2|Bacteria,2GR42@201174|Actinobacteria,4CWKT@84998|Coriobacteriia	84998|Coriobacteriia	J	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme	rnpA	-	3.1.26.5	ko:K03536	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_P
REGS2_k127_3349994_16	1121017.AUFG01000029_gene453	1.431e-27	116.0	COG0759@1|root,COG0759@2|Bacteria,2GQZG@201174|Actinobacteria,4FHQY@85021|Intrasporangiaceae	201174|Actinobacteria	S	Could be involved in insertion of integral membrane proteins into the membrane	-	-	-	ko:K08998	-	-	-	-	ko00000	-	-	-	Haemolytic
REGS2_k127_3349994_13	469378.Ccur_14180	2.231e-45	178.0	COG0706@1|root,COG0706@2|Bacteria,2GJBU@201174|Actinobacteria,4CUFT@84998|Coriobacteriia	84998|Coriobacteriia	U	Membrane protein insertase, YidC Oxa1 family	-	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP
REGS2_k127_3349994_10	479437.Elen_3120	3.078e-55	201.0	COG1847@1|root,COG1847@2|Bacteria,2GPZK@201174|Actinobacteria,4CUJI@84998|Coriobacteriia	84998|Coriobacteriia	S	R3H domain	-	-	-	ko:K06346	-	-	-	-	ko00000	-	-	-	KH_4,R3H
REGS2_k127_3349994_14	479437.Elen_3119	1.106e-38	156.0	COG0357@1|root,COG0357@2|Bacteria,2HUVU@201174|Actinobacteria,4CVTN@84998|Coriobacteriia	84998|Coriobacteriia	J	Specifically methylates the N7 position of a guanine in 16S rRNA	rsmG	-	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB
REGS2_k127_3349994_4	742722.HMPREF9463_00019	7.453e-107	352.0	COG1192@1|root,COG1192@2|Bacteria,2GMU7@201174|Actinobacteria,4CUR3@84998|Coriobacteriia	84998|Coriobacteriia	D	CobQ CobB MinD ParA nucleotide binding domain	soj	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
REGS2_k127_3349994_6	742722.HMPREF9463_00018	1.018e-81	280.0	COG1475@1|root,COG1475@2|Bacteria,2GNRN@201174|Actinobacteria,4CUFM@84998|Coriobacteriia	84998|Coriobacteriia	K	Belongs to the ParB family	-	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
REGS2_k127_3349994_21	251221.35214196	0.0002368	47.0	COG4980@1|root,COG4980@2|Bacteria,1G7T1@1117|Cyanobacteria	1117|Cyanobacteria	S	gas vesicle protein	-	-	-	-	-	-	-	-	-	-	-	-	YtxH
REGS2_k127_3349994_11	469383.Cwoe_1804	1.935e-51	209.0	COG3857@1|root,COG3857@2|Bacteria,2HNUC@201174|Actinobacteria,4CQ2I@84995|Rubrobacteria	84995|Rubrobacteria	L	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_1
REGS2_k127_3349994_2	1380390.JIAT01000014_gene6206	6.067e-125	440.0	COG1074@1|root,COG1074@2|Bacteria,2GNKH@201174|Actinobacteria,4CPD7@84995|Rubrobacteria	84995|Rubrobacteria	L	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
REGS2_k127_3349994_3	936550.HMPREF1492_1376	8.927e-118	394.0	COG0820@1|root,COG0820@2|Bacteria,2GJ48@201174|Actinobacteria,4CUGN@84998|Coriobacteriia	84998|Coriobacteriia	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	-	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Radical_SAM
REGS2_k127_3349994_12	742818.HMPREF9451_01624	3.388e-49	181.0	COG1592@1|root,COG1592@2|Bacteria,2I8N0@201174|Actinobacteria	201174|Actinobacteria	C	Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
REGS2_k127_3349994_9	1232436.CAPF01000070_gene975	6.802e-58	218.0	COG0265@1|root,COG0265@2|Bacteria,2GJ96@201174|Actinobacteria,4CV2A@84998|Coriobacteriia	84998|Coriobacteriia	O	PDZ DHR GLGF domain protein	-	-	-	ko:K08372	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Trypsin_2
REGS2_k127_3349994_5	479437.Elen_3114	8.175e-89	305.0	COG1181@1|root,COG1181@2|Bacteria,2GRWM@201174|Actinobacteria,4CU9A@84998|Coriobacteriia	84998|Coriobacteriia	F	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
REGS2_k127_3349994_15	700508.D174_23900	4.201e-33	149.0	COG5002@1|root,COG5002@2|Bacteria,2I2DU@201174|Actinobacteria,235KY@1762|Mycobacteriaceae	201174|Actinobacteria	T	Histidine kinase	phoR	-	2.7.13.3	ko:K02484	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
REGS2_k127_3349994_0	717605.Theco_2193	2.465e-217	707.0	COG0474@1|root,COG0474@2|Bacteria,1TPF5@1239|Firmicutes,4H9S5@91061|Bacilli,26RIF@186822|Paenibacillaceae	91061|Bacilli	P	P-type ATPase	pacL	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
REGS2_k127_3349994_7	861299.J421_2752	1.322e-68	244.0	COG1760@1|root,COG1760@2|Bacteria,1ZT3U@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Serine dehydratase alpha chain	-	-	4.3.1.17	ko:K01752	ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230	-	R00220,R00590	RC00331,RC02600	ko00000,ko00001,ko01000	-	-	-	SDH_alpha
REGS2_k127_3349994_18	748449.Halha_0507	6.868e-15	78.0	COG1918@1|root,COG1918@2|Bacteria,1VEQU@1239|Firmicutes,24R31@186801|Clostridia,3WAV2@53433|Halanaerobiales	186801|Clostridia	P	PFAM FeoA domain	-	-	-	ko:K04758	-	-	-	-	ko00000,ko02000	-	-	-	FeoA
REGS2_k127_3349994_1	635013.TherJR_1325	3.679e-206	658.0	COG0370@1|root,COG0370@2|Bacteria,1TP7E@1239|Firmicutes,24885@186801|Clostridia,2612J@186807|Peptococcaceae	186801|Clostridia	P	transporter of a GTP-driven Fe(2 ) uptake system	feoB	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
REGS2_k127_3349994_20	1120941.AUBL01000011_gene636	2.884e-11	72.0	COG0454@1|root,COG0456@2|Bacteria,2I7I3@201174|Actinobacteria,4D6D6@85005|Actinomycetales	201174|Actinobacteria	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
REGS2_k127_3349994_8	768710.DesyoDRAFT_4494	4.859e-62	224.0	COG1760@1|root,COG1760@2|Bacteria,1U8TZ@1239|Firmicutes,24AEE@186801|Clostridia,261NW@186807|Peptococcaceae	186801|Clostridia	E	TIGRFAM L-serine dehydratase, iron-sulfur-dependent, beta subunit	sdaAB	-	4.3.1.17	ko:K01752	ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230	-	R00220,R00590	RC00331,RC02600	ko00000,ko00001,ko01000	-	-	-	ACT,SDH_beta
REGS2_k127_3396456_0	502558.EGYY_29050	4.909e-161	527.0	COG1109@1|root,COG1109@2|Bacteria,2IB2T@201174|Actinobacteria,4CUQF@84998|Coriobacteriia	84998|Coriobacteriia	G	Phosphoglucomutase phosphomannomutase, alpha beta alpha domain II	-	-	-	-	-	-	-	-	-	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
REGS2_k127_3396456_6	1521187.JPIM01000044_gene3284	1.681e-48	198.0	COG0438@1|root,COG0438@2|Bacteria,2G7VV@200795|Chloroflexi,375M4@32061|Chloroflexia	32061|Chloroflexia	M	PFAM glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
REGS2_k127_3396456_7	926550.CLDAP_27810	1.795e-42	175.0	COG1216@1|root,COG1216@2|Bacteria,2G8DR@200795|Chloroflexi	200795|Chloroflexi	S	PFAM Glycosyl transferase family 2	-	-	-	ko:K07011	-	-	-	-	ko00000	-	-	-	Glycos_transf_2
REGS2_k127_3396456_4	1370122.JHXQ01000003_gene1293	1.983e-57	213.0	COG1091@1|root,COG1091@2|Bacteria,1MUXM@1224|Proteobacteria,2TSP6@28211|Alphaproteobacteria,4B8TK@82115|Rhizobiaceae	28211|Alphaproteobacteria	M	Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose	rfbD	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008831,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016051,GO:0016491,GO:0016614,GO:0016616,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0045226,GO:0046379,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	1.1.1.133	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000	-	-	-	RmlD_sub_bind
REGS2_k127_3396456_1	1234664.AMRO01000071_gene2959	1.034e-126	413.0	COG1088@1|root,COG1088@2|Bacteria,1TPWM@1239|Firmicutes,4HA3Y@91061|Bacilli,1WHF3@129337|Geobacillus	91061|Bacilli	M	Male sterility protein	rfbB	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
REGS2_k127_3396456_3	760568.Desku_0717	2.474e-62	221.0	COG1898@1|root,COG1898@2|Bacteria,1V4G5@1239|Firmicutes,24IZ8@186801|Clostridia,262MP@186807|Peptococcaceae	186801|Clostridia	M	dTDP-4-dehydrorhamnose 3,5-epimerase	-	-	5.1.3.13	ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R06514	RC01531	ko00000,ko00001,ko00002,ko01000	-	-	-	dTDP_sugar_isom
REGS2_k127_3396456_2	1115512.EH105704_17_00500	1.704e-118	388.0	COG1209@1|root,COG1209@2|Bacteria,1MU0X@1224|Proteobacteria,1RMTR@1236|Gammaproteobacteria,3XMX5@561|Escherichia	1236|Gammaproteobacteria	M	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis	rffH	GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0008879,GO:0009058,GO:0009059,GO:0009987,GO:0016051,GO:0016740,GO:0016772,GO:0016779,GO:0033692,GO:0034637,GO:0034645,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0045226,GO:0046379,GO:0046872,GO:0071704,GO:1901576	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iUMNK88_1353.UMNK88_4598,iYL1228.KPN_04289	NTP_transferase
REGS2_k127_3396456_5	42256.RradSPS_0233	5.877e-57	217.0	COG1216@1|root,COG1216@2|Bacteria,2GK2D@201174|Actinobacteria,4CQ6N@84995|Rubrobacteria	84995|Rubrobacteria	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
REGS2_k127_3396456_8	243160.BMA2300	9.672e-22	106.0	COG0438@1|root,COG0438@2|Bacteria,1MYC0@1224|Proteobacteria,2W4N3@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	DUF4214,Glycos_transf_1
REGS2_k127_3555171_0	1235794.C811_00761	0.0	1103.0	COG1197@1|root,COG1197@2|Bacteria,2GJ42@201174|Actinobacteria,4CV3I@84998|Coriobacteriia	84998|Coriobacteriia	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
REGS2_k127_3555171_4	1209989.TepiRe1_0182	8.668e-42	166.0	COG0760@1|root,COG0760@2|Bacteria,1TX3R@1239|Firmicutes,24C7H@186801|Clostridia,42GQY@68295|Thermoanaerobacterales	186801|Clostridia	M	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins	prsA	-	5.2.1.8	ko:K03769,ko:K07533	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_2,SurA_N_3,TPR_7
REGS2_k127_3555171_3	1408254.T458_25580	1.283e-80	295.0	COG1694@1|root,COG3956@2|Bacteria,1TPK1@1239|Firmicutes,4HA0A@91061|Bacilli,26QBT@186822|Paenibacillaceae	91061|Bacilli	S	Protein containing tetrapyrrole methyltransferase domain and MazG-like	yabN	GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009147,GO:0009149,GO:0009151,GO:0009155,GO:0009164,GO:0009166,GO:0009199,GO:0009200,GO:0009203,GO:0009204,GO:0009208,GO:0009210,GO:0009211,GO:0009213,GO:0009215,GO:0009217,GO:0009218,GO:0009219,GO:0009222,GO:0009223,GO:0009259,GO:0009261,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046046,GO:0046047,GO:0046051,GO:0046052,GO:0046060,GO:0046061,GO:0046070,GO:0046075,GO:0046076,GO:0046080,GO:0046081,GO:0046131,GO:0046133,GO:0046135,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658	3.6.1.66	ko:K02428,ko:K02499	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000,ko03036	-	-	-	MazG,TP_methylase
REGS2_k127_3555171_1	479437.Elen_2794	8.533e-205	647.0	COG0148@1|root,COG0148@2|Bacteria,2GJAY@201174|Actinobacteria,4CU81@84998|Coriobacteriia	84998|Coriobacteriia	H	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
REGS2_k127_3555171_2	935948.KE386494_gene496	5.54e-108	372.0	COG0469@1|root,COG0469@2|Bacteria,1TPGG@1239|Firmicutes,2489V@186801|Clostridia,42F1S@68295|Thermoanaerobacterales	186801|Clostridia	G	Belongs to the pyruvate kinase family	pyk	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PEP-utilizers,PK,PK_C
REGS2_k127_3602342_12	266117.Rxyl_2427	2.363e-31	138.0	2DBRF@1|root,2ZAKB@2|Bacteria,2IIVX@201174|Actinobacteria,4CQPW@84995|Rubrobacteria	84995|Rubrobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS2_k127_3602342_4	436229.JOEH01000006_gene2684	5.571e-54	201.0	COG0583@1|root,COG0583@2|Bacteria,2GNFT@201174|Actinobacteria,2NG8B@228398|Streptacidiphilus	201174|Actinobacteria	K	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
REGS2_k127_3602342_0	247156.NFA_47240	4.234e-77	267.0	COG0500@1|root,COG2226@2|Bacteria,2HCAN@201174|Actinobacteria,4FYHF@85025|Nocardiaceae	201174|Actinobacteria	Q	Methyltransferase	rrmA	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0008989,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0052912,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.187	ko:K00563	-	-	R07233	RC00003	ko00000,ko01000,ko03009	-	-	-	Methyltransf_11,Methyltransf_25
REGS2_k127_3602342_14	1043493.BBLU01000018_gene1586	7.379e-27	119.0	COG0716@1|root,COG0716@2|Bacteria	2|Bacteria	C	FMN binding	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_1,Flavodoxin_5
REGS2_k127_3602342_6	309799.DICTH_0645	2.536e-48	179.0	COG1435@1|root,COG1435@2|Bacteria	2|Bacteria	F	thymidine kinase activity	tdk	GO:0003674,GO:0003824,GO:0004797,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006259,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009120,GO:0009123,GO:0009124,GO:0009157,GO:0009162,GO:0009165,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0018130,GO:0019136,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046104,GO:0046125,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0090304,GO:0090407,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657	2.7.1.21	ko:K00857	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01567,R02099,R08233	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	iLJ478.TM0401	TK
REGS2_k127_3602342_17	653386.HMPREF0975_01888	1.918e-14	83.0	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,2GJ1J@201174|Actinobacteria,4D3IX@85005|Actinomycetales	201174|Actinobacteria	KLT	serine threonine protein kinase	pknL	GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018107,GO:0018193,GO:0018210,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036211,GO:0042304,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
REGS2_k127_3602342_18	485913.Krac_10081	7.072e-13	76.0	COG0762@1|root,COG0762@2|Bacteria,2G9JK@200795|Chloroflexi	200795|Chloroflexi	S	integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	YGGT
REGS2_k127_3602342_9	1003195.SCAT_0316	2.734e-39	154.0	COG4291@1|root,COG4291@2|Bacteria,2GIW8@201174|Actinobacteria	201174|Actinobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF1345
REGS2_k127_3602342_16	509190.Cseg_2297	3.408e-19	91.0	COG2261@1|root,COG2261@2|Bacteria,1NNKP@1224|Proteobacteria,2UGGY@28211|Alphaproteobacteria,2KJ88@204458|Caulobacterales	204458|Caulobacterales	S	PFAM Transglycosylase-associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
REGS2_k127_3602342_7	1081640.AGFU01000002_gene382	3.309e-47	173.0	COG0229@1|root,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,2U5Q0@28211|Alphaproteobacteria,2KD5R@204457|Sphingomonadales	204457|Sphingomonadales	O	Belongs to the MsrB Met sulfoxide reductase family	msrB	-	-	-	-	-	-	-	-	-	-	-	SelR
REGS2_k127_3602342_5	706587.Desti_1725	2.764e-52	189.0	COG0225@1|root,COG0225@2|Bacteria,1N2DQ@1224|Proteobacteria,42UC3@68525|delta/epsilon subdivisions,2WQBZ@28221|Deltaproteobacteria,2MS4Q@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Peptide methionine sulfoxide reductase	msrA	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
REGS2_k127_3602342_10	246194.CHY_0604	4.33e-36	150.0	COG3005@1|root,COG3005@2|Bacteria,1VBE7@1239|Firmicutes,2527F@186801|Clostridia	186801|Clostridia	C	NapC/NirT cytochrome c family, N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS2_k127_3602342_15	246194.CHY_0220	7.189e-21	109.0	COG3005@1|root,COG3005@2|Bacteria,1UDA7@1239|Firmicutes,253T2@186801|Clostridia,42IXK@68295|Thermoanaerobacterales	186801|Clostridia	C	denitrification pathway	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C7
REGS2_k127_3602342_11	246194.CHY_0220	1.731e-33	139.0	COG3005@1|root,COG3005@2|Bacteria,1UDA7@1239|Firmicutes,253T2@186801|Clostridia,42IXK@68295|Thermoanaerobacterales	186801|Clostridia	C	denitrification pathway	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C7
REGS2_k127_3602342_19	635013.TherJR_1847	1.353e-12	79.0	COG3005@1|root,COG3005@2|Bacteria,1VTRU@1239|Firmicutes,2500S@186801|Clostridia,264IC@186807|Peptococcaceae	186801|Clostridia	C	denitrification pathway	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS2_k127_3602342_8	871963.Desdi_3361	7.165e-46	181.0	COG5557@1|root,COG5557@2|Bacteria	2|Bacteria	C	Polysulphide reductase, NrfD	-	-	-	ko:K00185	-	-	-	-	ko00000	5.A.3	-	-	NrfD
REGS2_k127_3602342_1	987059.RBXJA2T_09412	3.964e-69	250.0	COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,2VKVM@28216|Betaproteobacteria,1KNAF@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_11,Fer4_3,Fer4_4,Fer4_7
REGS2_k127_3602342_20	404589.Anae109_2408	8.215e-12	75.0	28JYU@1|root,2Z9NZ@2|Bacteria,1N5J2@1224|Proteobacteria,42UJJ@68525|delta/epsilon subdivisions,2X7XY@28221|Deltaproteobacteria,2Z2S3@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS2_k127_3602342_3	1051632.TPY_1505	7.789e-63	224.0	COG0745@1|root,COG0745@2|Bacteria,1TPWS@1239|Firmicutes,25AZ2@186801|Clostridia,3WDTI@538999|Clostridiales incertae sedis	186801|Clostridia	K	Transcriptional regulatory protein, C terminal	phoP	-	-	ko:K02483,ko:K07658	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
REGS2_k127_3602342_2	370438.PTH_2684	4.877e-67	250.0	COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,247VG@186801|Clostridia,26181@186807|Peptococcaceae	186801|Clostridia	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	2.7.13.3	ko:K07651	ko02020,map02020	M00458	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_9
REGS2_k127_3602342_13	1121028.ARQE01000012_gene412	8.021e-31	138.0	COG0265@1|root,COG0265@2|Bacteria	2|Bacteria	O	serine-type endopeptidase activity	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	Beta_helix,CBM_6,DUF1565,PDZ_2,Trypsin_2
REGS2_k127_3721958_10	477974.Daud_1111	1.317e-76	262.0	COG0563@1|root,COG0563@2|Bacteria,1TP27@1239|Firmicutes,247YN@186801|Clostridia,260CT@186807|Peptococcaceae	186801|Clostridia	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iHN637.CLJU_RS20110	ADK,ADK_lid
REGS2_k127_3721958_8	498761.HM1_1400	2.177e-84	291.0	COG0024@1|root,COG0024@2|Bacteria,1TQC1@1239|Firmicutes,248I8@186801|Clostridia	186801|Clostridia	E	Methionine aminopeptidase	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
REGS2_k127_3721958_23	1121087.AUCK01000006_gene556	6.47e-37	141.0	COG0361@1|root,COG0361@2|Bacteria,1V9ZK@1239|Firmicutes,4HKF4@91061|Bacilli,1ZHWN@1386|Bacillus	91061|Bacilli	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	GO:0001871,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0009986,GO:0030246,GO:0030247,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:2001065	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
REGS2_k127_3721958_25	762948.HMPREF0733_10277	1.264e-15	78.0	COG0257@1|root,COG0257@2|Bacteria,2GWMH@201174|Actinobacteria,1WA8T@1268|Micrococcaceae	201174|Actinobacteria	J	Belongs to the bacterial ribosomal protein bL36 family	rpmJ	-	-	ko:K02919	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L36
REGS2_k127_3721958_17	1034345.CAEM01000057_gene538	1.455e-57	201.0	COG0099@1|root,COG0099@2|Bacteria,2IHPN@201174|Actinobacteria,4CVUM@84998|Coriobacteriia	84998|Coriobacteriia	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	-	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
REGS2_k127_3721958_13	471855.Shel_19730	2.087e-68	233.0	COG0100@1|root,COG0100@2|Bacteria,2IFFC@201174|Actinobacteria,4CVNX@84998|Coriobacteriia	84998|Coriobacteriia	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome	rpsK	-	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
REGS2_k127_3721958_7	479437.Elen_2805	4.795e-101	334.0	COG0522@1|root,COG0522@2|Bacteria,2GIRX@201174|Actinobacteria,4CV0K@84998|Coriobacteriia	84998|Coriobacteriia	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	-	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
REGS2_k127_3721958_4	700015.Corgl_1302	9.543e-110	362.0	COG0202@1|root,COG0202@2|Bacteria,2GJJ5@201174|Actinobacteria,4CUFQ@84998|Coriobacteriia	84998|Coriobacteriia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	-	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
REGS2_k127_3721958_24	484770.UFO1_0598	2.359e-34	134.0	COG0203@1|root,COG0203@2|Bacteria,1V6JQ@1239|Firmicutes,4H4TR@909932|Negativicutes	909932|Negativicutes	J	Ribosomal protein L17	rplQ	-	-	ko:K02879	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L17
REGS2_k127_3721958_12	1304284.L21TH_0923	1.217e-69	245.0	COG1122@1|root,COG1122@2|Bacteria,1TPH8@1239|Firmicutes,248A2@186801|Clostridia,36DXB@31979|Clostridiaceae	186801|Clostridia	P	ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates	ecfA1	-	-	ko:K16786,ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran
REGS2_k127_3721958_19	867903.ThesuDRAFT_00589	3.353e-46	183.0	COG1122@1|root,COG1122@2|Bacteria,1TPH8@1239|Firmicutes,248A2@186801|Clostridia,3WCXT@538999|Clostridiales incertae sedis	186801|Clostridia	P	ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates	-	-	-	ko:K16786,ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran
REGS2_k127_3721958_16	1235797.C816_00876	6.478e-60	218.0	COG0619@1|root,COG0619@2|Bacteria,1TQ0E@1239|Firmicutes,248AB@186801|Clostridia,2N6TG@216572|Oscillospiraceae	186801|Clostridia	P	Cobalt transport protein	ecfT	-	-	ko:K16785	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	CbiQ
REGS2_k127_3721958_11	479437.Elen_1051	4.674e-71	249.0	COG0101@1|root,COG0101@2|Bacteria,2GJ6C@201174|Actinobacteria,4CUTB@84998|Coriobacteriia	84998|Coriobacteriia	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	-	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
REGS2_k127_3721958_14	649764.HMPREF0762_01973	1.492e-63	222.0	COG0102@1|root,COG0102@2|Bacteria,2IFG1@201174|Actinobacteria,4CVR4@84998|Coriobacteriia	84998|Coriobacteriia	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	-	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
REGS2_k127_3721958_20	663278.Ethha_2600	7.076e-46	168.0	COG0103@1|root,COG0103@2|Bacteria,1V3MQ@1239|Firmicutes,24H94@186801|Clostridia,3WIS1@541000|Ruminococcaceae	186801|Clostridia	J	Belongs to the universal ribosomal protein uS9 family	rpsI	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
REGS2_k127_3721958_3	700015.Corgl_1425	4.68e-145	472.0	COG1109@1|root,COG1109@2|Bacteria,2GN87@201174|Actinobacteria,4CUZQ@84998|Coriobacteriia	84998|Coriobacteriia	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	-	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
REGS2_k127_3721958_1	1121472.AQWN01000001_gene281	1.402e-217	691.0	COG0449@1|root,COG0449@2|Bacteria,1TPGU@1239|Firmicutes,248F8@186801|Clostridia,2608Z@186807|Peptococcaceae	186801|Clostridia	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
REGS2_k127_3721958_22	479437.Elen_2209	6.721e-38	151.0	COG0736@1|root,COG0736@2|Bacteria,2HT7V@201174|Actinobacteria,4CVSA@84998|Coriobacteriia	84998|Coriobacteriia	I	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein	acpS	-	2.7.8.7	ko:K00997	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
REGS2_k127_3721958_9	290397.Adeh_1502	9.885e-82	292.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1MU1Q@1224|Proteobacteria,42ND6@68525|delta/epsilon subdivisions,2WIJS@28221|Deltaproteobacteria,2YURF@29|Myxococcales	28221|Deltaproteobacteria	H	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
REGS2_k127_3721958_21	926561.KB900620_gene3145	1.067e-39	153.0	COG0517@1|root,COG0517@2|Bacteria,1VA1X@1239|Firmicutes,24MNT@186801|Clostridia	186801|Clostridia	EGP	PFAM CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
REGS2_k127_3721958_5	1384484.AEQU_1547	1.621e-108	373.0	COG0787@1|root,COG0787@2|Bacteria,2GM2Y@201174|Actinobacteria,4CUW7@84998|Coriobacteriia	84998|Coriobacteriia	M	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
REGS2_k127_3721958_6	323259.Mhun_1764	2.319e-106	370.0	COG1269@1|root,arCOG04138@2157|Archaea,2XTQP@28890|Euryarchaeota	28890|Euryarchaeota	C	Belongs to the V-ATPase 116 kDa subunit family	atpI-2	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
REGS2_k127_3721958_28	323259.Mhun_1763	1.68e-05	51.0	COG0636@1|root,arCOG02455@2157|Archaea,2Y1B9@28890|Euryarchaeota	28890|Euryarchaeota	C	ATP synthase subunit C	-	-	-	ko:K02124	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_C
REGS2_k127_3721958_27	593750.Metfor_0255	3.393e-12	74.0	COG1390@1|root,arCOG00869@2157|Archaea,2Y46J@28890|Euryarchaeota,2NB12@224756|Methanomicrobia	224756|Methanomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpE-2	-	-	ko:K02121	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_E
REGS2_k127_3721958_15	593750.Metfor_0256	2.057e-60	228.0	COG1527@1|root,arCOG02459@2157|Archaea,2XTK5@28890|Euryarchaeota,2NAIS@224756|Methanomicrobia	224756|Methanomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC-2	-	-	ko:K02119	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_AC39
REGS2_k127_3721958_26	869210.Marky_1601	5.343e-13	73.0	COG1436@1|root,COG1436@2|Bacteria,1WKHR@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpF	-	-	ko:K02122	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_F
REGS2_k127_3721958_0	573064.Mefer_0464	9.757e-221	698.0	COG1155@1|root,arCOG00868@2157|Archaea,2XT8I@28890|Euryarchaeota,23Q05@183939|Methanococci	183939|Methanococci	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit	atpA	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0034220,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044464,GO:0044769,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132,GO:1902600	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
REGS2_k127_3721958_2	1041930.Mtc_2333	8.022e-217	681.0	COG1156@1|root,arCOG00865@2157|Archaea,2XSYQ@28890|Euryarchaeota,2NAB4@224756|Methanomicrobia	224756|Methanomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit	atpB-2	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
REGS2_k127_3721958_18	323259.Mhun_1757	1.658e-52	192.0	COG1394@1|root,arCOG04101@2157|Archaea	2157|Archaea	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpD	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
REGS2_k127_3745741_11	1280706.AUJE01000021_gene933	1.568e-38	148.0	COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,4H2JC@909932|Negativicutes	909932|Negativicutes	IQ	reductase	fabG	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
REGS2_k127_3745741_8	1185876.BN8_06347	7.325e-54	201.0	COG0331@1|root,COG0331@2|Bacteria,4NE1D@976|Bacteroidetes,47JDE@768503|Cytophagia	976|Bacteroidetes	I	malonyl CoA-acyl carrier protein transacylase	fabD	-	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
REGS2_k127_3745741_2	635013.TherJR_2076	3.525e-118	387.0	COG2070@1|root,COG2070@2|Bacteria,1TPC3@1239|Firmicutes,24831@186801|Clostridia,260H0@186807|Peptococcaceae	186801|Clostridia	S	PFAM 2-nitropropane dioxygenase	fabK	-	1.3.1.9	ko:K02371	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00083	R04429,R04724,R04955,R04958,R04961,R04966,R04969,R07765	RC00052,RC00076	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	iHN637.CLJU_RS20775	NMO
REGS2_k127_3745741_4	1123368.AUIS01000009_gene2485	6.74e-101	339.0	COG0332@1|root,COG0332@2|Bacteria,1MU9N@1224|Proteobacteria,1RNIR@1236|Gammaproteobacteria,2NC1U@225057|Acidithiobacillales	225057|Acidithiobacillales	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
REGS2_k127_3745741_3	1034345.CAEM01000023_gene793	7.236e-107	356.0	COG0416@1|root,COG0416@2|Bacteria,2I8WT@201174|Actinobacteria,4CURT@84998|Coriobacteriia	84998|Coriobacteriia	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA	plsX	-	2.3.1.15	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_synthesis
REGS2_k127_3745741_6	195250.CM001776_gene2076	5.285e-66	243.0	COG0857@1|root,COG0857@2|Bacteria,1G0QB@1117|Cyanobacteria,1GZVA@1129|Synechococcus	1117|Cyanobacteria	C	BioD-like N-terminal domain of phosphotransacetylase	pta	-	-	ko:K06873	-	-	-	-	ko00000	-	-	-	AAA_26,DRTGG
REGS2_k127_3745741_1	1128421.JAGA01000002_gene371	2.36e-194	634.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,2NNW5@2323|unclassified Bacteria	2|Bacteria	C	synthetase (ADP forming), alpha	-	-	6.2.1.13	ko:K01905,ko:K09181,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,Acetyltransf_1,CoA_binding_2,Succ_CoA_lig
REGS2_k127_3745741_13	243231.GSU1599	2.524e-15	83.0	COG0333@1|root,COG0333@2|Bacteria,1NGM1@1224|Proteobacteria,42XHF@68525|delta/epsilon subdivisions,2WSX6@28221|Deltaproteobacteria,43SSW@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	structural constituent of ribosome	rpmF	GO:0003674,GO:0003735,GO:0005198	-	ko:K02911	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_L32p
REGS2_k127_3745741_14	485913.Krac_8242	4.146e-13	77.0	COG1399@1|root,COG1399@2|Bacteria,2G6Z5@200795|Chloroflexi	200795|Chloroflexi	S	Uncharacterized ACR, COG1399	-	-	-	ko:K07040	-	-	-	-	ko00000	-	-	-	DUF177
REGS2_k127_3745741_10	469383.Cwoe_3698	3.56e-44	165.0	COG0711@1|root,COG0711@2|Bacteria,2HNZ4@201174|Actinobacteria,4CQ8B@84995|Rubrobacteria	84995|Rubrobacteria	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS2_k127_3745741_7	471855.Shel_10020	4.93e-54	197.0	COG0669@1|root,COG0669@2|Bacteria,2GN1S@201174|Actinobacteria,4CVRP@84998|Coriobacteriia	84998|Coriobacteriia	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	-	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
REGS2_k127_3745741_12	1192034.CAP_1417	2.037e-36	147.0	COG0742@1|root,COG0742@2|Bacteria,1MXKW@1224|Proteobacteria,42U1F@68525|delta/epsilon subdivisions,2WQQM@28221|Deltaproteobacteria,2YVK3@29|Myxococcales	28221|Deltaproteobacteria	L	Conserved hypothetical protein 95	-	-	2.1.1.171	ko:K08316	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Cons_hypoth95
REGS2_k127_3745741_0	633147.Olsu_1064	6.368e-196	635.0	COG1200@1|root,COG1200@2|Bacteria,2GKA3@201174|Actinobacteria,4CUY8@84998|Coriobacteriia	84998|Coriobacteriia	L	ATP-dependent DNA helicase RecG	-	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
REGS2_k127_3745741_9	1121087.AUCK01000001_gene2648	2.834e-52	195.0	COG1307@1|root,COG1307@2|Bacteria,1TQDI@1239|Firmicutes,4HF8Z@91061|Bacilli,1ZRGY@1386|Bacillus	91061|Bacilli	S	Uncharacterised protein, DegV family COG1307	-	-	-	-	-	-	-	-	-	-	-	-	DegV
REGS2_k127_3745741_5	502558.EGYY_17480	3.81e-81	280.0	COG1461@1|root,COG1461@2|Bacteria,2GKII@201174|Actinobacteria,4CUVH@84998|Coriobacteriia	84998|Coriobacteriia	S	DAK2 domain fusion protein YloV	-	-	-	ko:K07030	-	-	-	-	ko00000	-	-	-	Dak1_2,Dak2
REGS2_k127_395269_10	1227360.C176_02184	0.0001612	50.0	COG0860@1|root,COG3103@1|root,COG0860@2|Bacteria,COG4991@2|Bacteria,1UYPW@1239|Firmicutes,4HBVT@91061|Bacilli,26CYS@186818|Planococcaceae	91061|Bacilli	M	N-acetylmuramoyl-L-alanine amidase	lytH	GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_3,SH3_3
REGS2_k127_395269_1	502558.EGYY_13870	3.416e-164	539.0	COG1541@1|root,COG1541@2|Bacteria,2GJC7@201174|Actinobacteria,4CUCR@84998|Coriobacteriia	84998|Coriobacteriia	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	-	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
REGS2_k127_395269_5	1279038.KB907339_gene1291	7.742e-76	263.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2TR61@28211|Alphaproteobacteria,2JQ6B@204441|Rhodospirillales	204441|Rhodospirillales	E	COG0410 ABC-type branched-chain amino acid transport systems, ATPase component	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
REGS2_k127_395269_2	690585.JNNU01000041_gene982	3.964e-77	265.0	COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2TQK1@28211|Alphaproteobacteria,4BAID@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
REGS2_k127_395269_8	243231.GSU1732	9.917e-55	209.0	COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,42MAQ@68525|delta/epsilon subdivisions,2WKK0@28221|Deltaproteobacteria,43U03@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	Branched-chain amino acid transport system / permease component	livM	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	iAF987.Gmet_1821	BPD_transp_2
REGS2_k127_395269_4	709797.CSIRO_3102	2.297e-76	265.0	COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,2TSDS@28211|Alphaproteobacteria,3JV87@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
REGS2_k127_395269_6	667014.Thein_0251	5.913e-66	244.0	COG0683@1|root,COG0683@2|Bacteria,2GI8J@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	E	Periplasmic binding protein domain	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
REGS2_k127_395269_3	1121406.JAEX01000003_gene1501	4.123e-77	275.0	COG0683@1|root,COG0683@2|Bacteria,1MXR4@1224|Proteobacteria,42MXX@68525|delta/epsilon subdivisions,2WKJM@28221|Deltaproteobacteria,2M7W7@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	PFAM Extracellular ligand-binding receptor	livK-1	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	iAF987.Gmet_1823	Peripla_BP_6
REGS2_k127_395269_9	643648.Slip_0779	1.715e-37	145.0	COG4747@1|root,COG4747@2|Bacteria,1V7U2@1239|Firmicutes,24JE5@186801|Clostridia,42JZR@68298|Syntrophomonadaceae	186801|Clostridia	S	ACT domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ACT
REGS2_k127_395269_7	1504822.CCNO01000014_gene1185	1.311e-58	221.0	COG1014@1|root,COG1014@2|Bacteria	2|Bacteria	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	iorB	-	1.2.7.8	ko:K00180	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR
REGS2_k127_395269_0	370438.PTH_2846	3.087e-206	657.0	COG4231@1|root,COG4231@2|Bacteria,1TNY3@1239|Firmicutes,247U1@186801|Clostridia,260MU@186807|Peptococcaceae	186801|Clostridia	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	iorA	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,POR_N,TPP_enzyme_C
REGS2_k127_4017455_5	1121468.AUBR01000023_gene2750	5.162e-83	287.0	COG0559@1|root,COG0559@2|Bacteria,1TR24@1239|Firmicutes,2480A@186801|Clostridia,42F37@68295|Thermoanaerobacterales	186801|Clostridia	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
REGS2_k127_4017455_8	1123499.KB908030_gene608	2.161e-72	260.0	COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,2VH43@28216|Betaproteobacteria,2KPXB@206351|Neisseriales	206351|Neisseriales	E	Branched-chain amino acid transport system / permease component	livM	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
REGS2_k127_4017455_3	1121406.JAEX01000001_gene187	2.638e-93	313.0	COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,42NMG@68525|delta/epsilon subdivisions,2WJIS@28221|Deltaproteobacteria,2M8EX@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	PFAM ABC transporter related	livG	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
REGS2_k127_4017455_6	1499967.BAYZ01000173_gene5796	2.424e-82	286.0	COG0410@1|root,COG0410@2|Bacteria,2NNXF@2323|unclassified Bacteria	2|Bacteria	E	ABC transporter	livF	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
REGS2_k127_4017455_10	574087.Acear_0510	1.743e-51	201.0	COG0402@1|root,COG0402@2|Bacteria,1TP43@1239|Firmicutes,248IX@186801|Clostridia,3WB7T@53433|Halanaerobiales	186801|Clostridia	F	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine	mtaD	GO:0003674,GO:0003824,GO:0016787,GO:0016810,GO:0016814,GO:0019239,GO:0050270	3.5.4.28,3.5.4.31,3.5.4.40	ko:K12960,ko:K20810	ko00130,ko00270,ko01100,ko01110,map00130,map00270,map01100,map01110	-	R09660,R10695	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
REGS2_k127_4017455_4	1121472.AQWN01000003_gene1478	2.341e-89	305.0	COG0005@1|root,COG0005@2|Bacteria,1TQ37@1239|Firmicutes,248NB@186801|Clostridia,260M8@186807|Peptococcaceae	186801|Clostridia	F	Phosphorylase superfamily	-	-	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
REGS2_k127_4017455_9	35841.BT1A1_1666	6.329e-53	203.0	COG1252@1|root,COG1252@2|Bacteria,1TR6X@1239|Firmicutes,4HA14@91061|Bacilli,1ZAV9@1386|Bacillus	91061|Bacilli	C	NADH dehydrogenase	ndh	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	DoxX,Pyr_redox_2
REGS2_k127_4017455_1	760568.Desku_1548	1.063e-128	427.0	COG1060@1|root,COG1060@2|Bacteria,1TRHG@1239|Firmicutes,247Z2@186801|Clostridia,2609W@186807|Peptococcaceae	186801|Clostridia	H	Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnC	-	1.21.98.1,2.5.1.77	ko:K11779,ko:K11784	ko00130,ko00680,ko01110,ko01120,map00130,map00680,map01110,map01120	M00378	R08588,R09396	RC01381,RC02329,RC03002,RC03007	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
REGS2_k127_4017455_7	1123288.SOV_2c12430	4.639e-73	256.0	COG1427@1|root,COG1427@2|Bacteria,1V2PX@1239|Firmicutes,4H1XN@909932|Negativicutes	909932|Negativicutes	S	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnA	-	4.2.1.151	ko:K11782	ko00130,ko01110,map00130,map01110	-	R10666	RC03232	ko00000,ko00001,ko01000	-	-	-	VitK2_biosynth
REGS2_k127_4017455_0	246194.CHY_1806	1.392e-133	435.0	COG1060@1|root,COG1060@2|Bacteria,1TQNG@1239|Firmicutes,24AHE@186801|Clostridia,42FB5@68295|Thermoanaerobacterales	186801|Clostridia	H	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate	mqnE	-	2.5.1.120	ko:K18285	ko00130,ko01110,map00130,map01110	-	R10667	RC00021,RC03234	ko00000,ko00001,ko01000	-	-	-	Radical_SAM
REGS2_k127_4017455_2	1307761.L21SP2_2147	1.36e-93	320.0	COG1732@1|root,COG1732@2|Bacteria	2|Bacteria	M	glycine betaine transport	yehZ	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006950,GO:0006970,GO:0006972,GO:0008150,GO:0009628,GO:0009987,GO:0015695,GO:0015696,GO:0015697,GO:0015838,GO:0016020,GO:0031460,GO:0033554,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0071214,GO:0071470,GO:0071474,GO:0071702,GO:0071705,GO:0071944,GO:0072337,GO:0104004	-	ko:K05845	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	iE2348C_1286.E2348C_2278,iEC55989_1330.EC55989_2381,iECIAI39_1322.ECIAI39_0865,iECO103_1326.ECO103_2607,iECSE_1348.ECSE_2399	OpuAC
REGS2_k127_4017455_11	626418.bglu_1g18350	2.388e-32	136.0	COG1174@1|root,COG1174@2|Bacteria,1MXA1@1224|Proteobacteria,2VPU5@28216|Betaproteobacteria,1JZNX@119060|Burkholderiaceae	28216|Betaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K05846	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	BPD_transp_1
REGS2_k127_4045652_19	404380.Gbem_1732	1.486e-24	111.0	COG0454@1|root,COG0456@2|Bacteria,1QZ6C@1224|Proteobacteria	1224|Proteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10
REGS2_k127_4045652_8	1504822.CCNO01000014_gene1087	3.483e-104	346.0	COG4974@1|root,COG4974@2|Bacteria,2NNN8@2323|unclassified Bacteria	2|Bacteria	L	Phage integrase, N-terminal SAM-like domain	xerD	GO:0008150,GO:0040007	-	ko:K03733,ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
REGS2_k127_4045652_11	1123274.KB899414_gene3746	9.111e-85	293.0	COG1744@1|root,COG1744@2|Bacteria	2|Bacteria	ET	ABC transporter substrate-binding protein PnrA-like	yufN	-	-	ko:K02058,ko:K07335	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	Bmp
REGS2_k127_4045652_0	1236973.JCM9157_3434	2.25e-179	577.0	COG3845@1|root,COG3845@2|Bacteria,1UYQA@1239|Firmicutes,4HVSH@91061|Bacilli,1ZS12@1386|Bacillus	91061|Bacilli	S	ABC transporter, ATP-binding protein	yufO	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
REGS2_k127_4045652_12	858215.Thexy_1937	4.373e-84	293.0	COG4603@1|root,COG4603@2|Bacteria,1TP1F@1239|Firmicutes,2494C@186801|Clostridia,42FNB@68295|Thermoanaerobacterales	186801|Clostridia	P	Belongs to the binding-protein-dependent transport system permease family	rbsC	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
REGS2_k127_4045652_15	373903.Hore_08800	5.044e-80	279.0	COG1079@1|root,COG1079@2|Bacteria,1TP8Y@1239|Firmicutes,2486N@186801|Clostridia,3WA6M@53433|Halanaerobiales	186801|Clostridia	S	PFAM Branched-chain amino acid transport system permease component	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
REGS2_k127_4045652_17	1041930.Mtc_0139	9.66e-29	130.0	arCOG04609@1|root,arCOG04609@2157|Archaea,2XVS1@28890|Euryarchaeota,2N9XU@224756|Methanomicrobia	224756|Methanomicrobia	S	Domain of unknown function (DUF4349)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4349
REGS2_k127_4045652_16	877421.AUJT01000002_gene1301	9.38e-35	138.0	COG2001@1|root,COG2001@2|Bacteria,1V3JD@1239|Firmicutes,24HB9@186801|Clostridia,27MPS@186928|unclassified Lachnospiraceae	186801|Clostridia	K	MraZ protein, putative antitoxin-like	mraZ	-	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
REGS2_k127_4045652_4	700015.Corgl_0754	1.095e-116	383.0	COG0275@1|root,COG0275@2|Bacteria,2GJGK@201174|Actinobacteria,4CUEV@84998|Coriobacteriia	84998|Coriobacteriia	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	-	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
REGS2_k127_4045652_5	338963.Pcar_2208	2.983e-115	397.0	COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,42M1T@68525|delta/epsilon subdivisions,2WK0W@28221|Deltaproteobacteria,43TBV@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	PASTA domain	ftsI	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PASTA,PBP_dimer,Transpeptidase
REGS2_k127_4045652_3	469378.Ccur_09540	3.414e-135	445.0	COG0769@1|root,COG0769@2|Bacteria,2GIS2@201174|Actinobacteria,4CUCK@84998|Coriobacteriia	84998|Coriobacteriia	M	Belongs to the MurCDEF family. MurE subfamily	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
REGS2_k127_4045652_7	1089553.Tph_c12600	1.019e-104	357.0	COG0770@1|root,COG0770@2|Bacteria,1VT78@1239|Firmicutes,25100@186801|Clostridia,42EWR@68295|Thermoanaerobacterales	186801|Clostridia	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
REGS2_k127_4045652_6	1384484.AEQU_1425	6.899e-112	371.0	COG0472@1|root,COG0472@2|Bacteria,2GNEH@201174|Actinobacteria,4CUYB@84998|Coriobacteriia	84998|Coriobacteriia	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
REGS2_k127_4045652_9	1125712.HMPREF1316_0386	6.629e-104	355.0	COG0771@1|root,COG0771@2|Bacteria,2GJZA@201174|Actinobacteria,4CUT4@84998|Coriobacteriia	84998|Coriobacteriia	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase_C,Mur_ligase_M
REGS2_k127_4045652_14	1246484.D479_16844	2.905e-81	287.0	COG0772@1|root,COG0772@2|Bacteria,1TPT7@1239|Firmicutes,4HAEV@91061|Bacilli,3NEBT@45667|Halobacillus	91061|Bacilli	D	Cell cycle protein	spoVE	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
REGS2_k127_4045652_10	742818.HMPREF9451_01104	1.266e-88	307.0	COG0707@1|root,COG0707@2|Bacteria,2GJEM@201174|Actinobacteria,4CUWJ@84998|Coriobacteriia	84998|Coriobacteriia	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
REGS2_k127_4045652_2	1034345.CAEM01000017_gene1634	1.017e-141	471.0	COG0773@1|root,COG0773@2|Bacteria,2I2E7@201174|Actinobacteria,4CUCI@84998|Coriobacteriia	84998|Coriobacteriia	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
REGS2_k127_4045652_13	1232436.CAPF01000020_gene1025	6.128e-82	283.0	COG0812@1|root,COG0812@2|Bacteria,2GIV2@201174|Actinobacteria,4CUCU@84998|Coriobacteriia	84998|Coriobacteriia	M	Cell wall formation	murB_1	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
REGS2_k127_4045652_18	502558.EGYY_09620	1.92e-28	127.0	COG1589@1|root,COG1589@2|Bacteria,2HUMN@201174|Actinobacteria,4CV4T@84998|Coriobacteriia	84998|Coriobacteriia	D	Cell division protein FtsQ	-	-	-	ko:K03589	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036	-	-	-	FtsQ,POTRA_1
REGS2_k127_4045652_20	1122921.KB898185_gene3930	5.648e-18	94.0	COG1376@1|root,COG1376@2|Bacteria,1V9XU@1239|Firmicutes,4HKDD@91061|Bacilli,26Y7D@186822|Paenibacillaceae	91061|Bacilli	S	ErfK YbiS YcfS YnhG family protein	ykuD	-	-	-	-	-	-	-	-	-	-	-	LysM,YkuD
REGS2_k127_4045652_1	42256.RradSPS_1496	6.496e-147	474.0	COG0206@1|root,COG0206@2|Bacteria,2GJWC@201174|Actinobacteria,4CP7W@84995|Rubrobacteria	84995|Rubrobacteria	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
REGS2_k127_411715_1	1128421.JAGA01000002_gene1449	5.551e-84	290.0	COG2201@1|root,COG2201@2|Bacteria,2NNUY@2323|unclassified Bacteria	2|Bacteria	NT	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	cheB	-	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,CheD,Response_reg
REGS2_k127_411715_0	1223521.BBJX01000002_gene2825	6.2e-139	471.0	COG0643@1|root,COG0745@1|root,COG0643@2|Bacteria,COG0745@2|Bacteria,1MUAG@1224|Proteobacteria,2VJSZ@28216|Betaproteobacteria,4ACMW@80864|Comamonadaceae	28216|Betaproteobacteria	T	Two component signalling adaptor domain	-	GO:0003674,GO:0005488,GO:0005515,GO:0019904	2.7.13.3	ko:K03407,ko:K13490	ko02020,ko02025,ko02030,map02020,map02025,map02030	M00506,M00509	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,HATPase_c,Hpt,Response_reg
REGS2_k127_411715_3	351607.Acel_1872	3.073e-55	209.0	COG0840@1|root,COG0840@2|Bacteria,2IA80@201174|Actinobacteria	201174|Actinobacteria	NT	chemotaxis	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CHASE3,MCPsignal
REGS2_k127_411715_6	401526.TcarDRAFT_2008	1.546e-16	91.0	COG0835@1|root,COG0835@2|Bacteria,1V4HH@1239|Firmicutes,4H4NR@909932|Negativicutes	909932|Negativicutes	NT	PFAM CheW domain protein	cheW	-	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
REGS2_k127_411715_5	207559.Dde_2040	7.555e-17	92.0	COG0835@1|root,COG0835@2|Bacteria,1RD1W@1224|Proteobacteria,42T5Y@68525|delta/epsilon subdivisions,2WNT6@28221|Deltaproteobacteria,2MAZR@213115|Desulfovibrionales	28221|Deltaproteobacteria	NT	PFAM CheW domain protein	-	-	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
REGS2_k127_411715_2	1125863.JAFN01000001_gene2904	3.248e-57	224.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2WIPP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	NU	PFAM Type II secretion system protein E	pilB	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N,cNMP_binding
REGS2_k127_411715_4	575540.Isop_3677	2.93e-28	123.0	COG0745@1|root,COG0745@2|Bacteria,2J342@203682|Planctomycetes	203682|Planctomycetes	T	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	ko:K02658	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko02022,ko02035,ko02044	-	-	-	Response_reg
REGS2_k127_411715_7	323848.Nmul_A0330	5.161e-16	83.0	COG0457@1|root,COG1352@1|root,COG0457@2|Bacteria,COG1352@2|Bacteria,1R6N1@1224|Proteobacteria,2VPB1@28216|Betaproteobacteria,374K4@32003|Nitrosomonadales	28216|Betaproteobacteria	NT	Methyltransferase, chemotaxis proteins	-	-	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheR
REGS2_k127_4162891_1	1111135.HMPREF1248_0260	2.496e-170	551.0	COG0539@1|root,COG0539@2|Bacteria,2GJAK@201174|Actinobacteria,4CV59@84998|Coriobacteriia	84998|Coriobacteriia	J	Ribosomal protein S1	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
REGS2_k127_4162891_2	526225.Gobs_3196	5.737e-42	164.0	COG0237@1|root,COG0237@2|Bacteria,2GN96@201174|Actinobacteria,4ESVT@85013|Frankiales	201174|Actinobacteria	H	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	GO:0000166,GO:0001882,GO:0001884,GO:0002135,GO:0003674,GO:0003824,GO:0004140,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0018130,GO:0019103,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032549,GO:0032551,GO:0032552,GO:0032553,GO:0032554,GO:0032557,GO:0032558,GO:0032564,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CoaE,GrpB
REGS2_k127_4162891_3	429009.Adeg_1021	1.472e-27	121.0	COG0741@1|root,COG0741@2|Bacteria,1V6K4@1239|Firmicutes,24JB5@186801|Clostridia,42GIF@68295|Thermoanaerobacterales	186801|Clostridia	M	PFAM Lytic transglycosylase catalytic	slt	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	SLT
REGS2_k127_4162891_0	1223543.GP2_062_00100	1.46e-261	833.0	COG0556@1|root,COG0556@2|Bacteria,2GJ03@201174|Actinobacteria,4GBXY@85026|Gordoniaceae	201174|Actinobacteria	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	GO:0002682,GO:0002684,GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0008150,GO:0009605,GO:0009607,GO:0016020,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0044464,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051409,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052564,GO:0052572,GO:0065007,GO:0071944,GO:0075136	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
REGS2_k127_4251881_15	479437.Elen_2066	3.915e-26	119.0	COG1522@1|root,COG1522@2|Bacteria,2IIXK@201174|Actinobacteria	201174|Actinobacteria	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_AsnC-type
REGS2_k127_4251881_1	469378.Ccur_12330	2.327e-185	591.0	COG0535@1|root,COG0535@2|Bacteria,2GNSY@201174|Actinobacteria,4CUKZ@84998|Coriobacteriia	84998|Coriobacteriia	C	Iron-sulfur cluster-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM,SPASM
REGS2_k127_4251881_4	471855.Shel_11640	3.022e-142	467.0	COG0113@1|root,COG0113@2|Bacteria,2GJJ0@201174|Actinobacteria,4CVAC@84998|Coriobacteriia	84998|Coriobacteriia	H	Belongs to the ALAD family	-	-	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
REGS2_k127_4251881_0	479437.Elen_2068	2.817e-219	687.0	COG0535@1|root,COG0535@2|Bacteria,2GNSY@201174|Actinobacteria,4CXA7@84998|Coriobacteriia	84998|Coriobacteriia	C	Radical SAM	-	-	-	ko:K22226	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SPASM
REGS2_k127_4251881_2	696281.Desru_1622	6.124e-180	582.0	COG0007@1|root,COG1587@1|root,COG0007@2|Bacteria,COG1587@2|Bacteria,1TQNH@1239|Firmicutes,2487I@186801|Clostridia,2602S@186807|Peptococcaceae	186801|Clostridia	H	Belongs to the precorrin methyltransferase family	cobA	-	1.3.1.76,2.1.1.107,4.2.1.75,4.99.1.4	ko:K02302,ko:K02303,ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03165,R03194,R03947	RC00003,RC00871,RC01012,RC01034,RC01861	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS15755	HEM4,Porphobil_deam,Porphobil_deamC,TP_methylase
REGS2_k127_4251881_6	498761.HM1_1965	1.358e-94	322.0	COG0181@1|root,COG0181@2|Bacteria,1TPFQ@1239|Firmicutes,2494Z@186801|Clostridia	186801|Clostridia	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	-	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS15760	Porphobil_deam,Porphobil_deamC
REGS2_k127_4251881_5	1125863.JAFN01000001_gene1123	7.243e-128	423.0	COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,42MUG@68525|delta/epsilon subdivisions,2WISB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	-	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
REGS2_k127_4251881_13	448385.sce4676	1.016e-55	204.0	COG0300@1|root,COG0300@2|Bacteria,1RGKZ@1224|Proteobacteria,43BQ7@68525|delta/epsilon subdivisions,2X7IJ@28221|Deltaproteobacteria,2Z3IA@29|Myxococcales	28221|Deltaproteobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
REGS2_k127_4251881_12	479437.Elen_2072	4.85e-58	221.0	COG1648@1|root,COG1648@2|Bacteria,2GTES@201174|Actinobacteria,4CW19@84998|Coriobacteriia	84998|Coriobacteriia	H	TIGRFAM siroheme synthase	-	-	1.3.1.76,4.99.1.4	ko:K02304	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03947	RC01012,RC01034	ko00000,ko00001,ko00002,ko01000	-	-	-	NAD_binding_7,Sirohm_synth_M
REGS2_k127_4251881_19	1123508.JH636440_gene2531	4.297e-10	70.0	COG0755@1|root,COG0755@2|Bacteria,2IZXD@203682|Planctomycetes	203682|Planctomycetes	O	PFAM Cytochrome c assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
REGS2_k127_4251881_18	1235794.C811_00033	2.067e-11	66.0	2B1N0@1|root,32CVJ@2|Bacteria,2HVCR@201174|Actinobacteria,4CWNT@84998|Coriobacteriia	84998|Coriobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS2_k127_4251881_10	742818.HMPREF9451_01207	5.711e-74	256.0	COG0755@1|root,COG0755@2|Bacteria,2IIHK@201174|Actinobacteria,4CU7P@84998|Coriobacteriia	84998|Coriobacteriia	O	Cytochrome c assembly protein	-	-	-	ko:K02195	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	Cytochrom_C_asm
REGS2_k127_4251881_11	502558.EGYY_02140	1.156e-60	224.0	COG2386@1|root,COG2386@2|Bacteria,2GUCP@201174|Actinobacteria,4CV8U@84998|Coriobacteriia	84998|Coriobacteriia	O	heme exporter protein CcmB	-	-	-	ko:K02194	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	CcmB
REGS2_k127_4251881_7	1034345.CAEM01000025_gene1124	1.423e-93	319.0	COG1131@1|root,COG1131@2|Bacteria,2H5DY@201174|Actinobacteria,4CV85@84998|Coriobacteriia	84998|Coriobacteriia	V	PFAM ABC transporter	-	-	3.6.3.41,3.6.3.7	ko:K01990,ko:K02193,ko:K09697	ko02010,ko02020,map02010,map02020	M00253,M00254,M00259	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.107,3.A.1.115	-	-	ABC_tran,Rad17
REGS2_k127_4251881_3	742742.HMPREF9452_01050	1.847e-167	550.0	COG1138@1|root,COG1138@2|Bacteria,2HZM9@201174|Actinobacteria,4CV75@84998|Coriobacteriia	84998|Coriobacteriia	O	biogenesis protein CcmF	-	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
REGS2_k127_4251881_16	469378.Ccur_04980	6.134e-21	104.0	COG2332@1|root,COG2332@2|Bacteria,2HUFT@201174|Actinobacteria,4CUH1@84998|Coriobacteriia	84998|Coriobacteriia	O	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH	-	-	-	ko:K02197	-	-	-	-	ko00000	-	-	-	CcmE
REGS2_k127_4251881_8	1089553.Tph_c26220	1.114e-83	290.0	COG5322@1|root,COG5322@2|Bacteria,1TQ2E@1239|Firmicutes,24A1Y@186801|Clostridia,42EUN@68295|Thermoanaerobacterales	186801|Clostridia	S	oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS2_k127_4251881_14	264732.Moth_0148	2.17e-36	146.0	2AVM5@1|root,31MDW@2|Bacteria,1V7D6@1239|Firmicutes,24JAJ@186801|Clostridia,42G0V@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM helix-turn-helix domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
REGS2_k127_4251881_9	717605.Theco_3678	8.82e-76	267.0	COG1521@1|root,COG1521@2|Bacteria,1TR0X@1239|Firmicutes,4H9QA@91061|Bacilli,26RR9@186822|Paenibacillaceae	91061|Bacilli	H	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis	coaX	-	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Pan_kinase
REGS2_k127_4251881_17	941449.dsx2_1686	5.019e-13	72.0	COG0068@1|root,COG0068@2|Bacteria,1MVP8@1224|Proteobacteria,42M3G@68525|delta/epsilon subdivisions,2WJ51@28221|Deltaproteobacteria,2M8IT@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide	hypF	-	-	ko:K04656	-	-	-	-	ko00000	-	-	iAF987.Gmet_0119	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
REGS2_k127_427531_2	479437.Elen_3078	1.369e-54	196.0	COG1109@1|root,COG1109@2|Bacteria,2IB2T@201174|Actinobacteria,4CUQF@84998|Coriobacteriia	84998|Coriobacteriia	G	Phosphoglucomutase phosphomannomutase, alpha beta alpha domain II	-	-	-	-	-	-	-	-	-	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
REGS2_k127_427531_0	572479.Hprae_0340	1.154e-74	264.0	COG0438@1|root,COG0438@2|Bacteria,1V2NV@1239|Firmicutes,25ERN@186801|Clostridia	186801|Clostridia	M	PFAM Glycosyl transferase, group 1	-	-	2.4.1.348	ko:K06338,ko:K12995	-	-	-	-	ko00000,ko01000,ko01003,ko01005	-	GT4	-	Glyco_transf_4,Glycos_transf_1
REGS2_k127_427531_1	264732.Moth_0669	1.42e-72	261.0	COG2148@1|root,COG2148@2|Bacteria,1TP7M@1239|Firmicutes,248WV@186801|Clostridia,42FNK@68295|Thermoanaerobacterales	186801|Clostridia	M	TIGRFAM exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf,CoA_binding_3,Glyco_trans_1_4
REGS2_k127_427531_3	1414720.CBYM010000019_gene2450	1.675e-08	68.0	COG3307@1|root,COG3307@2|Bacteria,1V6KK@1239|Firmicutes,25BNJ@186801|Clostridia,36WKX@31979|Clostridiaceae	186801|Clostridia	M	O-Antigen ligase	-	-	-	-	-	-	-	-	-	-	-	-	Wzy_C
REGS2_k127_427531_4	1040982.AXAL01000011_gene1154	8.827e-08	63.0	COG0457@1|root,COG0457@2|Bacteria,1RKBA@1224|Proteobacteria,2TRAV@28211|Alphaproteobacteria,43RSN@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_2,TPR_8
REGS2_k127_4298003_0	479437.Elen_0280	5.408e-156	505.0	COG0460@1|root,COG0460@2|Bacteria,2GIX9@201174|Actinobacteria,4CUZW@84998|Coriobacteriia	84998|Coriobacteriia	E	homoserine dehydrogenase	-	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,Homoserine_dh,NAD_binding_3
REGS2_k127_4298003_6	266117.Rxyl_3124	9.059e-57	209.0	COG0083@1|root,COG0083@2|Bacteria,2GKIW@201174|Actinobacteria,4CQEJ@84995|Rubrobacteria	84995|Rubrobacteria	E	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate	thrB	-	2.7.1.39	ko:K00872	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
REGS2_k127_4298003_4	266117.Rxyl_1658	2.283e-83	297.0	COG1409@1|root,COG1409@2|Bacteria	2|Bacteria	S	acid phosphatase activity	CP_0969	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Metallophos_2
REGS2_k127_4298003_2	266117.Rxyl_1657	5.523e-109	370.0	COG2403@1|root,COG2403@2|Bacteria,2H3G5@201174|Actinobacteria	201174|Actinobacteria	F	Catalyzes the formation of cyclic 2,3-diphosphoglycerate (cDPG) by formation of an intramolecular phosphoanhydride bond at the expense of ATP	cpgS	-	-	ko:K05716	-	-	R03298	RC00900	ko00000,ko01000	-	-	-	-
REGS2_k127_4298003_5	319795.Dgeo_1765	1.911e-63	235.0	COG2074@1|root,COG2074@2|Bacteria,1WI2U@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	2-phosphoglycerate kinase	-	-	-	ko:K05715	-	-	R02664	RC00002,RC00017	ko00000,ko01000	-	-	-	ATP-cone
REGS2_k127_4298003_3	742818.HMPREF9451_01274	1.427e-107	353.0	COG0176@1|root,COG0176@2|Bacteria,2GSF7@201174|Actinobacteria,4CUDU@84998|Coriobacteriia	84998|Coriobacteriia	H	Transaldolase	fsa	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
REGS2_k127_4298003_1	479437.Elen_1088	8.056e-112	372.0	COG1158@1|root,COG1158@2|Bacteria,2GIWY@201174|Actinobacteria,4CU9T@84998|Coriobacteriia	84998|Coriobacteriia	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind,SAP
REGS2_k127_4552214_4	428125.CLOLEP_01061	1.115e-31	125.0	COG0184@1|root,COG0184@2|Bacteria,1VA5C@1239|Firmicutes,24MRM@186801|Clostridia,3WK6U@541000|Ruminococcaceae	186801|Clostridia	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	-	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
REGS2_k127_4552214_0	198467.NP92_06375	1.138e-237	755.0	COG1185@1|root,COG1185@2|Bacteria,1TQDW@1239|Firmicutes,4H9Z3@91061|Bacilli,21V27@150247|Anoxybacillus	91061|Bacilli	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004654,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
REGS2_k127_4552214_1	656024.FsymDg_3632	2.934e-107	363.0	COG0612@1|root,COG0612@2|Bacteria,2GJZ3@201174|Actinobacteria,4ERHK@85013|Frankiales	201174|Actinobacteria	S	Belongs to the peptidase M16 family	pepR	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
REGS2_k127_4552214_3	1125971.ASJB01000015_gene5779	5.47e-67	254.0	COG0289@1|root,COG0289@2|Bacteria,2GM2T@201174|Actinobacteria,4DYC5@85010|Pseudonocardiales	201174|Actinobacteria	E	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate	dapB	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0030312,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0048037,GO:0050661,GO:0050662,GO:0051287,GO:0055114,GO:0070402,GO:0070404,GO:0071704,GO:0071944,GO:0097159,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2773c	DapB_C,DapB_N
REGS2_k127_4552214_2	555079.Toce_0625	3.751e-98	334.0	COG0527@1|root,COG0527@2|Bacteria,1TPQJ@1239|Firmicutes,24811@186801|Clostridia,42F4C@68295|Thermoanaerobacterales	186801|Clostridia	E	Belongs to the aspartokinase family	dapG	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT_7
REGS2_k127_4552214_5	1384484.AEQU_1068	1.572e-28	118.0	COG0329@1|root,COG0329@2|Bacteria,2GJ34@201174|Actinobacteria,4CV9Z@84998|Coriobacteriia	84998|Coriobacteriia	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
REGS2_k127_4583471_5	649764.HMPREF0762_02069	5.434e-71	245.0	COG0717@1|root,COG0717@2|Bacteria,2GKQQ@201174|Actinobacteria,4CXCW@84998|Coriobacteriia	84998|Coriobacteriia	F	Belongs to the dCTP deaminase family	dcd	-	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	DCD
REGS2_k127_4583471_2	742742.HMPREF9452_01199	1.072e-83	290.0	COG0644@1|root,COG0644@2|Bacteria,2HG45@201174|Actinobacteria,4CYAM@84998|Coriobacteriia	84998|Coriobacteriia	C	FAD binding domain	-	-	-	ko:K00313	-	-	-	-	ko00000,ko01000	-	-	-	-
REGS2_k127_4583471_9	502558.EGYY_10510	6.792e-17	84.0	2BU9W@1|root,32PJE@2|Bacteria,2HV7D@201174|Actinobacteria,4CWFT@84998|Coriobacteriia	84998|Coriobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS2_k127_4583471_7	536232.CLM_2281	5.938e-44	170.0	COG0177@1|root,COG0177@2|Bacteria,1VNUP@1239|Firmicutes,256XV@186801|Clostridia	186801|Clostridia	L	FES	-	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	-
REGS2_k127_4583471_0	404589.Anae109_1414	2.359e-86	305.0	COG4198@1|root,COG4198@2|Bacteria,1NPPY@1224|Proteobacteria,42NTB@68525|delta/epsilon subdivisions,2WKNX@28221|Deltaproteobacteria,2Z31V@29|Myxococcales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF1015)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1015
REGS2_k127_4583471_10	189426.PODO_23710	1.158e-15	89.0	COG4392@1|root,COG4392@2|Bacteria,1VH9Q@1239|Firmicutes,4HNDZ@91061|Bacilli,26YEZ@186822|Paenibacillaceae	91061|Bacilli	S	branched-chain amino acid	azlD	-	-	-	-	-	-	-	-	-	-	-	AzlD
REGS2_k127_4583471_8	882.DVU_0031	6.466e-36	154.0	COG1296@1|root,COG1296@2|Bacteria,1P6U3@1224|Proteobacteria,42QVQ@68525|delta/epsilon subdivisions,2WMW1@28221|Deltaproteobacteria,2MAJ4@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	PFAM AzlC family protein	-	-	-	-	-	-	-	-	-	-	-	-	AzlC
REGS2_k127_4583471_6	1121271.AUCM01000008_gene3169	3.93e-55	204.0	COG0705@1|root,COG0705@2|Bacteria,1MYFP@1224|Proteobacteria,2TSJG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	membrane protein (homolog of Drosophila rhomboid)	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
REGS2_k127_4583471_4	1047013.AQSP01000139_gene2393	3.272e-72	249.0	COG1704@1|root,COG1704@2|Bacteria,2NPIW@2323|unclassified Bacteria	2|Bacteria	S	LemA family	lemA2	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
REGS2_k127_4583471_3	1047013.AQSP01000139_gene2394	5.402e-83	286.0	COG0501@1|root,COG0501@2|Bacteria,2NP1V@2323|unclassified Bacteria	2|Bacteria	O	Belongs to the peptidase M48B family	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	DUF3318,Peptidase_M48
REGS2_k127_4583471_1	502558.EGYY_10530	1.269e-85	290.0	COG0682@1|root,COG0682@2|Bacteria,2GKSS@201174|Actinobacteria,4CUQA@84998|Coriobacteriia	84998|Coriobacteriia	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
REGS2_k127_4653918_4	1144275.COCOR_00433	2.333e-10	67.0	COG2161@1|root,COG2161@2|Bacteria,1N7B5@1224|Proteobacteria,42V0B@68525|delta/epsilon subdivisions,2WS9N@28221|Deltaproteobacteria	28221|Deltaproteobacteria	D	Antitoxin component of a toxin-antitoxin (TA) module	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
REGS2_k127_4653918_3	411466.ACTODO_02145	4.927e-20	93.0	COG2026@1|root,COG2026@2|Bacteria,2IRES@201174|Actinobacteria,4D63R@85005|Actinomycetales	201174|Actinobacteria	DJ	ParE toxin of type II toxin-antitoxin system, parDE	-	-	-	ko:K06218	-	-	-	-	ko00000,ko02048	-	-	-	ParE_toxin
REGS2_k127_4653918_2	1117379.BABA_03274	7.447e-21	105.0	COG2234@1|root,COG2234@2|Bacteria,1UHWN@1239|Firmicutes,4HGPC@91061|Bacilli,1ZDXC@1386|Bacillus	91061|Bacilli	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
REGS2_k127_4653918_1	1034345.CAEM01000008_gene1274	2.25e-150	489.0	COG0019@1|root,COG0019@2|Bacteria,2GKAI@201174|Actinobacteria,4CV4B@84998|Coriobacteriia	84998|Coriobacteriia	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
REGS2_k127_4653918_0	1235794.C811_00279	3.838e-190	609.0	COG0018@1|root,COG0018@2|Bacteria,2GKQ3@201174|Actinobacteria,4CUI3@84998|Coriobacteriia	84998|Coriobacteriia	J	Arginyl-tRNA synthetase	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
REGS2_k127_4656976_15	484770.UFO1_1724	3.173e-40	162.0	COG2896@1|root,COG2896@2|Bacteria,1VGXN@1239|Firmicutes	1239|Firmicutes	H	4Fe-4S single cluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM
REGS2_k127_4656976_13	537972.ABQU01000014_gene726	3.616e-42	175.0	COG2896@1|root,COG2896@2|Bacteria,1N9EE@1224|Proteobacteria	1224|Proteobacteria	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM
REGS2_k127_4656976_16	596152.DesU5LDRAFT_0036	1.249e-38	160.0	COG0726@1|root,COG0726@2|Bacteria,1MVKH@1224|Proteobacteria,42VRI@68525|delta/epsilon subdivisions,2WRUV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	PFAM Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
REGS2_k127_4656976_9	192952.MM_2103	1.553e-60	221.0	COG0500@1|root,arCOG07825@2157|Archaea	2157|Archaea	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
REGS2_k127_4656976_29	1357272.AVEO02000182_gene4301	9.171e-06	58.0	COG2244@1|root,COG2244@2|Bacteria,1RIXW@1224|Proteobacteria,1RQP6@1236|Gammaproteobacteria,1Z61Y@136849|Pseudomonas syringae group	1236|Gammaproteobacteria	S	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_3,Polysacc_synt_C
REGS2_k127_4656976_14	1313172.YM304_30110	6.847e-41	175.0	COG1216@1|root,COG3475@1|root,COG1216@2|Bacteria,COG3475@2|Bacteria	2|Bacteria	M	LICD family	licD	-	-	ko:K07271	-	-	-	-	ko00000,ko01000	-	-	-	Glycos_transf_2,LicD
REGS2_k127_4656976_4	111780.Sta7437_1070	1.044e-100	344.0	COG0438@1|root,COG0438@2|Bacteria,1G1VE@1117|Cyanobacteria,3VI7K@52604|Pleurocapsales	1117|Cyanobacteria	M	PFAM Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
REGS2_k127_4656976_20	946483.Cenrod_1766	2.633e-28	132.0	COG1216@1|root,COG1216@2|Bacteria,1RB30@1224|Proteobacteria,2VQYN@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Glycosyltransferase like family 2	-	-	-	ko:K13002	-	-	-	-	ko00000,ko01000,ko01003,ko01005	-	GT2	-	Glycos_transf_2
REGS2_k127_4656976_21	936572.HMPREF1148_1335	9.568e-27	124.0	COG0438@1|root,COG0438@2|Bacteria,1VFZT@1239|Firmicutes	1239|Firmicutes	M	PFAM Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
REGS2_k127_4656976_6	1380763.BG53_11530	4.762e-73	258.0	2DBCR@1|root,2Z8FA@2|Bacteria,1V8ZT@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS2_k127_4656976_30	515635.Dtur_1384	1.001e-05	59.0	COG0457@1|root,COG3307@1|root,COG0457@2|Bacteria,COG3307@2|Bacteria	2|Bacteria	M	-O-antigen	-	-	-	ko:K18814	-	-	-	-	ko00000,ko02000	9.B.67.1	-	-	TPR_2,TPR_8,Wzy_C
REGS2_k127_4656976_2	443143.GM18_0608	4.147e-208	661.0	COG1032@1|root,COG1032@2|Bacteria,1MWR0@1224|Proteobacteria,42ZYI@68525|delta/epsilon subdivisions,2WVGV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	1.21.98.3	ko:K04034	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R06268,R06269,R06270	RC00741,RC01491,RC01492	ko00000,ko00001,ko01000	-	-	-	B12-binding,Radical_SAM
REGS2_k127_4656976_22	1437425.CSEC_0393	4.737e-23	110.0	COG1186@1|root,COG1186@2|Bacteria,2JH72@204428|Chlamydiae	204428|Chlamydiae	J	RF-1 domain	-	-	-	-	-	-	-	-	-	-	-	-	RF-1
REGS2_k127_4656976_23	511051.CSE_01440	1.837e-20	96.0	COG2426@1|root,COG2426@2|Bacteria	2|Bacteria	S	small multidrug export protein	-	-	-	-	-	-	-	-	-	-	-	-	Sm_multidrug_ex
REGS2_k127_4656976_8	204669.Acid345_0471	4.8e-62	235.0	COG0484@1|root,COG0484@2|Bacteria	2|Bacteria	O	heat shock protein binding	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS2_k127_4656976_3	706587.Desti_3013	6.547e-107	371.0	COG0247@1|root,COG1150@1|root,COG0247@2|Bacteria,COG1150@2|Bacteria,1MUMH@1224|Proteobacteria,42N9U@68525|delta/epsilon subdivisions,2WINY@28221|Deltaproteobacteria	1224|Proteobacteria	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
REGS2_k127_4656976_25	1449126.JQKL01000042_gene1027	4.243e-18	94.0	COG2181@1|root,COG2181@2|Bacteria,1V6BS@1239|Firmicutes,249A5@186801|Clostridia	186801|Clostridia	C	PFAM Nitrate reductase gamma subunit	-	-	-	-	-	-	-	-	-	-	-	-	Nitrate_red_gam
REGS2_k127_4656976_24	706587.Desti_3015	3.072e-18	87.0	COG0425@1|root,COG0425@2|Bacteria,1MZA5@1224|Proteobacteria,42VCF@68525|delta/epsilon subdivisions,2WRI6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Belongs to the sulfur carrier protein TusA family	-	-	-	ko:K04085	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	TusA
REGS2_k127_4656976_17	469596.HMPREF9488_02016	1.124e-35	141.0	COG0446@1|root,COG0607@1|root,COG2210@1|root,COG0446@2|Bacteria,COG0607@2|Bacteria,COG2210@2|Bacteria,1TPWW@1239|Firmicutes,3VPVM@526524|Erysipelotrichia	526524|Erysipelotrichia	C	Belongs to the sulfur carrier protein TusA family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE_2,Fer4,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2,Pyr_redox_dim,Rhodanese,TusA
REGS2_k127_4656976_27	519442.Huta_1816	1.979e-15	81.0	COG0640@1|root,arCOG01681@2157|Archaea	2157|Archaea	K	regulatory protein, arsR	merR	-	2.1.1.137	ko:K07755,ko:K21903	-	-	-	-	ko00000,ko01000,ko03000	-	-	-	HTH_5
REGS2_k127_4656976_5	1123508.JH636439_gene722	5.621e-86	293.0	COG1432@1|root,COG1432@2|Bacteria,2IY4C@203682|Planctomycetes	203682|Planctomycetes	S	OST-HTH/LOTUS domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN,OST-HTH
REGS2_k127_4656976_11	649764.HMPREF0762_00002	7.177e-52	188.0	COG0652@1|root,COG0652@2|Bacteria,2HUQ0@201174|Actinobacteria,4CVCH@84998|Coriobacteriia	84998|Coriobacteriia	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	-	-	5.2.1.8	ko:K03768	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Pro_isomerase
REGS2_k127_4656976_10	644282.Deba_0147	2.542e-55	209.0	COG2515@1|root,COG2515@2|Bacteria,1MVYF@1224|Proteobacteria,42PWI@68525|delta/epsilon subdivisions,2WPU4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Pyridoxal-phosphate dependent enzyme	-	-	4.4.1.15	ko:K05396	ko00270,map00270	-	R01874	RC00382	ko00000,ko00001,ko01000	-	-	-	PALP
REGS2_k127_4656976_1	243233.MCA0712	1.42e-210	701.0	COG0116@1|root,COG1092@1|root,COG0116@2|Bacteria,COG1092@2|Bacteria,1MUQM@1224|Proteobacteria,1RNMH@1236|Gammaproteobacteria,1XEC9@135618|Methylococcales	135618|Methylococcales	J	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA	rlmL	-	2.1.1.173,2.1.1.264	ko:K12297	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM,THUMP,UPF0020
REGS2_k127_4656976_26	1121335.Clst_1640	1.737e-15	77.0	COG1141@1|root,COG1141@2|Bacteria,1VGNV@1239|Firmicutes,259E5@186801|Clostridia,3WQRA@541000|Ruminococcaceae	186801|Clostridia	C	4Fe-4S single cluster domain of Ferredoxin I	-	-	-	ko:K05337	-	-	-	-	ko00000	-	-	-	Fer4_13
REGS2_k127_4656976_12	582515.KR51_00032820	9.783e-46	177.0	COG1451@1|root,COG1451@2|Bacteria,1G6GG@1117|Cyanobacteria	1117|Cyanobacteria	S	Metal-dependent hydrolase	-	-	-	ko:K07043	-	-	-	-	ko00000	-	-	-	DUF45
REGS2_k127_4656976_0	926550.CLDAP_21080	3.526e-318	996.0	COG0474@1|root,COG0474@2|Bacteria,2G60Z@200795|Chloroflexi	200795|Chloroflexi	P	Cation transporting ATPase, C-terminus	-	-	3.6.3.2	ko:K01531	-	-	-	-	ko00000,ko01000	3.A.3.4	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
REGS2_k127_4656976_18	926569.ANT_06790	6.75e-31	132.0	COG0457@1|root,COG0457@2|Bacteria,2G770@200795|Chloroflexi	200795|Chloroflexi	S	Domain of unknown function (DUF4388)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4388
REGS2_k127_4656976_7	1232410.KI421424_gene1730	9.921e-68	254.0	COG1352@1|root,COG1352@2|Bacteria,1R6N1@1224|Proteobacteria,42T12@68525|delta/epsilon subdivisions,2WPTY@28221|Deltaproteobacteria,43TRF@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Methyltransferase, chemotaxis proteins	-	-	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheR,CheR_N,Response_reg,TPR_16
REGS2_k127_4656976_19	575540.Isop_3677	3.312e-29	121.0	COG0745@1|root,COG0745@2|Bacteria,2J342@203682|Planctomycetes	203682|Planctomycetes	T	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	ko:K02658	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko02022,ko02035,ko02044	-	-	-	Response_reg
REGS2_k127_4682540_5	635013.TherJR_2420	2.423e-48	188.0	COG1470@1|root,COG1470@2|Bacteria,1TRGE@1239|Firmicutes,24EHG@186801|Clostridia	186801|Clostridia	D	Protein of unknown function (DUF3048) C-terminal domain	yerB	-	-	-	-	-	-	-	-	-	-	-	DUF3048,DUF3048_C
REGS2_k127_4682540_1	479437.Elen_1109	2.798e-153	490.0	COG0214@1|root,COG0214@2|Bacteria,2GK1T@201174|Actinobacteria,4CUJ0@84998|Coriobacteriia	84998|Coriobacteriia	H	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively	pdxS	-	4.3.3.6	ko:K06215	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SOR_SNZ
REGS2_k127_4682540_4	1123023.JIAI01000029_gene4439	1.326e-64	229.0	COG0311@1|root,COG0311@2|Bacteria,2GNYG@201174|Actinobacteria,4DXHN@85010|Pseudonocardiales	201174|Actinobacteria	H	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS	pdxT	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0008614,GO:0009058,GO:0009108,GO:0009110,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016829,GO:0016840,GO:0016843,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0040007,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0051716,GO:0071496,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1902494,GO:1903600	4.3.3.6	ko:K08681	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SNO
REGS2_k127_4682540_3	1034345.CAEM01000054_gene1390	9.595e-93	315.0	COG0217@1|root,COG0217@2|Bacteria,2GJ4G@201174|Actinobacteria,4CUS6@84998|Coriobacteriia	84998|Coriobacteriia	K	transcriptional regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
REGS2_k127_4682540_8	675815.VOA_003196	1.18e-30	131.0	COG3153@1|root,COG3153@2|Bacteria,1RA42@1224|Proteobacteria,1S2G0@1236|Gammaproteobacteria,1XWYS@135623|Vibrionales	135623|Vibrionales	S	Acetyltransferase	yhbS	-	-	ko:K03824	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_7,Acetyltransf_9
REGS2_k127_4682540_6	866774.HMPREF9248_0479	5.083e-48	179.0	COG0817@1|root,COG0817@2|Bacteria,2GJI5@201174|Actinobacteria,4CVR2@84998|Coriobacteriia	84998|Coriobacteriia	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group	ruvC	-	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
REGS2_k127_4682540_7	1034345.CAEM01000054_gene1388	4.268e-42	167.0	COG0632@1|root,COG0632@2|Bacteria,2GN17@201174|Actinobacteria,4CVUX@84998|Coriobacteriia	84998|Coriobacteriia	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB	ruvA	-	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
REGS2_k127_4682540_0	1384484.AEQU_1384	1.625e-159	510.0	COG2255@1|root,COG2255@2|Bacteria,2GJZF@201174|Actinobacteria,4CUPG@84998|Coriobacteriia	84998|Coriobacteriia	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
REGS2_k127_4682540_9	270374.MELB17_18264	2.143e-09	70.0	COG0501@1|root,COG0501@2|Bacteria,1MVU4@1224|Proteobacteria,1RPJ5@1236|Gammaproteobacteria,46584@72275|Alteromonadaceae	1236|Gammaproteobacteria	O	COG0501 Zn-dependent protease with chaperone function	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
REGS2_k127_4682540_2	164757.Mjls_3416	4.031e-125	410.0	COG1064@1|root,COG1064@2|Bacteria,2GKNW@201174|Actinobacteria,237XV@1762|Mycobacteriaceae	201174|Actinobacteria	S	alcohol dehydrogenase	sadh	-	1.1.1.1	ko:K13953,ko:K18382	ko00010,ko00071,ko00350,ko00625,ko00626,ko00640,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00640,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310,R10703	RC00050,RC00087,RC00088,RC00099,RC00116,RC00545,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
REGS2_k127_4817148_1	161156.JQKW01000014_gene238	5.393e-162	521.0	COG0174@1|root,COG0174@2|Bacteria,2GH5N@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	E	Glutamine synthetase, catalytic domain	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
REGS2_k127_4817148_0	644282.Deba_0692	2.037e-250	784.0	COG2070@1|root,COG2070@2|Bacteria,1QZ4T@1224|Proteobacteria,43CFR@68525|delta/epsilon subdivisions,2X7QT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Conserved region in glutamate synthase	-	-	-	-	-	-	-	-	-	-	-	-	Glu_synthase
REGS2_k127_4817148_7	679926.Mpet_1050	2.317e-06	53.0	COG3585@1|root,arCOG00228@2157|Archaea	2157|Archaea	H	PFAM TOBE domain	mop	-	-	ko:K02019	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,TOBE
REGS2_k127_4817148_6	1437603.BMON_1701	2.298e-09	64.0	COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria,4CZ24@85004|Bifidobacteriales	201174|Actinobacteria	P	E1-E2 ATPase	-	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	Cupredoxin_1,E1-E2_ATPase,HMA,Hydrolase,YHS
REGS2_k127_4817148_4	1120973.AQXL01000125_gene3150	9.458e-74	272.0	COG2120@1|root,COG2120@2|Bacteria,1TQM2@1239|Firmicutes,4HGT7@91061|Bacilli,27898@186823|Alicyclobacillaceae	91061|Bacilli	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
REGS2_k127_4817148_2	760011.Spico_0438	4.678e-97	327.0	COG1117@1|root,COG1117@2|Bacteria,2J6DF@203691|Spirochaetes	203691|Spirochaetes	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
REGS2_k127_4817148_3	293826.Amet_4622	1.536e-77	280.0	COG0581@1|root,COG0581@2|Bacteria,1TP74@1239|Firmicutes,248C4@186801|Clostridia,36DCX@31979|Clostridiaceae	186801|Clostridia	P	Phosphate transport system permease protein PstA	pstA	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1,DUF3333
REGS2_k127_4817148_5	192952.MM_2006	6.015e-68	239.0	COG0573@1|root,arCOG00167@2157|Archaea,2XTYD@28890|Euryarchaeota,2NBPF@224756|Methanomicrobia	224756|Methanomicrobia	P	probably responsible for the translocation of the substrate across the membrane	pstC	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
REGS2_k127_4940234_15	1298860.AUEM01000009_gene2301	6.766e-14	85.0	COG5479@1|root,COG5479@2|Bacteria,2HYIN@201174|Actinobacteria,4FMC4@85023|Microbacteriaceae	201174|Actinobacteria	M	hydrolase, family 25	wcqK	-	-	-	-	-	-	-	-	-	-	-	CW_binding_2,LGFP,SH3_3
REGS2_k127_4940234_12	1121106.JQKB01000012_gene4682	2.237e-29	134.0	COG0265@1|root,COG0823@1|root,COG2931@1|root,COG0265@2|Bacteria,COG0823@2|Bacteria,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	ko:K08372	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	HemolysinCabind,NACHT,PDZ_2,Trypsin_2,VCBS
REGS2_k127_4940234_0	264732.Moth_2259	2.406e-224	707.0	COG0129@1|root,COG0129@2|Bacteria,1TP1R@1239|Firmicutes,247UC@186801|Clostridia,42ERZ@68295|Thermoanaerobacterales	186801|Clostridia	H	Belongs to the IlvD Edd family	ilvD	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
REGS2_k127_4940234_1	479437.Elen_1877	8.963e-221	698.0	COG0028@1|root,COG0028@2|Bacteria,2GKU4@201174|Actinobacteria,4CUQ8@84998|Coriobacteriia	84998|Coriobacteriia	H	Thiamine pyrophosphate enzyme, central domain	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
REGS2_k127_4940234_11	1232436.CAPF01000072_gene997	5.069e-64	223.0	COG0440@1|root,COG0440@2|Bacteria,2GJCH@201174|Actinobacteria,4CUNX@84998|Coriobacteriia	84998|Coriobacteriia	E	ACT domain	ilvN	-	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,ACT_5,ALS_ss_C
REGS2_k127_4940234_6	1262914.BN533_00421	1.476e-140	465.0	COG0059@1|root,COG0059@2|Bacteria,1TPI7@1239|Firmicutes,4H1XP@909932|Negativicutes	909932|Negativicutes	H	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
REGS2_k127_4940234_9	289376.THEYE_A0936	7.25e-116	388.0	COG0075@1|root,COG0075@2|Bacteria,3J0FC@40117|Nitrospirae	40117|Nitrospirae	E	Evidence 2b Function of strongly homologous gene	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
REGS2_k127_4940234_4	479437.Elen_1873	1.008e-162	543.0	COG1052@1|root,COG1052@2|Bacteria,2I2RK@201174|Actinobacteria,4CUMA@84998|Coriobacteriia	84998|Coriobacteriia	E	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
REGS2_k127_4940234_3	1118060.CAGZ01000014_gene1526	3.053e-206	665.0	COG0119@1|root,COG0119@2|Bacteria,2GISX@201174|Actinobacteria,4CUG3@84998|Coriobacteriia	84998|Coriobacteriia	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
REGS2_k127_4940234_2	502558.EGYY_22220	8.914e-215	677.0	COG0065@1|root,COG0065@2|Bacteria,2GKT7@201174|Actinobacteria,4CUFG@84998|Coriobacteriia	84998|Coriobacteriia	H	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
REGS2_k127_4940234_10	633147.Olsu_1543	1.428e-75	261.0	COG0066@1|root,COG0066@2|Bacteria,2GJ8Z@201174|Actinobacteria,4CVQ4@84998|Coriobacteriia	84998|Coriobacteriia	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
REGS2_k127_4940234_5	479437.Elen_0585	3.375e-156	500.0	COG0473@1|root,COG0473@2|Bacteria,2HABY@201174|Actinobacteria,4CUT5@84998|Coriobacteriia	84998|Coriobacteriia	C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
REGS2_k127_4940234_8	1384484.AEQU_1885	1.805e-118	394.0	COG0115@1|root,COG0115@2|Bacteria,2GKJ1@201174|Actinobacteria,4CV50@84998|Coriobacteriia	84998|Coriobacteriia	H	Branched-chain amino acid aminotransferase	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
REGS2_k127_4940234_13	768706.Desor_1586	5.294e-23	108.0	2EIQA@1|root,33CFR@2|Bacteria,1W559@1239|Firmicutes,254YN@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS2_k127_4940234_7	42256.RradSPS_0358	1.17e-131	440.0	COG2909@1|root,COG2909@2|Bacteria,2HENR@201174|Actinobacteria,4CPC9@84995|Rubrobacteria	84995|Rubrobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	ko:K03556	-	-	-	-	ko00000,ko03000	-	-	-	AAA_16,AAA_22,GerE
REGS2_k127_5039604_8	742818.HMPREF9451_00448	2.161e-49	178.0	COG0292@1|root,COG0292@2|Bacteria,2IHTN@201174|Actinobacteria,4CVXQ@84998|Coriobacteriia	84998|Coriobacteriia	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	-	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
REGS2_k127_5039604_9	156889.Mmc1_0365	3.162e-17	86.0	COG0291@1|root,COG0291@2|Bacteria	2|Bacteria	J	Belongs to the bacterial ribosomal protein bL35 family	rpmI	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02916	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35p
REGS2_k127_5039604_4	445975.COLSTE_01352	3.333e-71	250.0	COG0290@1|root,COG0290@2|Bacteria,2GJGT@201174|Actinobacteria,4CUA6@84998|Coriobacteriia	84998|Coriobacteriia	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	-	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
REGS2_k127_5039604_10	357808.RoseRS_3625	2.573e-08	63.0	COG0515@1|root,COG0515@2|Bacteria,2G7ZW@200795|Chloroflexi,37567@32061|Chloroflexia	32061|Chloroflexia	KLT	SMART tyrosine protein kinase	-	-	2.7.11.1	ko:K08884	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
REGS2_k127_5039604_3	2325.TKV_c18800	1.656e-111	372.0	COG0642@1|root,COG2205@2|Bacteria,1TQHB@1239|Firmicutes,247S4@186801|Clostridia,42EMD@68295|Thermoanaerobacterales	186801|Clostridia	T	PFAM Signal transduction histidine kinase, osmosensitive K channel sensor, N-terminal	-	-	2.7.13.3	ko:K07646	ko02020,map02020	M00454	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF4118,GAF_3,HATPase_c,HisKA,KdpD,Usp
REGS2_k127_5039604_7	1331060.RLDS_13070	9.022e-50	183.0	COG2156@1|root,COG2156@2|Bacteria,1RABG@1224|Proteobacteria,2TSQ7@28211|Alphaproteobacteria,2K2ZB@204457|Sphingomonadales	204457|Sphingomonadales	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex	kdpC	-	3.6.3.12	ko:K01548	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	-	KdpC
REGS2_k127_5039604_0	1267533.KB906735_gene4778	5.794e-286	893.0	COG2216@1|root,COG2216@2|Bacteria,3Y302@57723|Acidobacteria,2JHQI@204432|Acidobacteriia	204432|Acidobacteriia	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system	kdpB	-	3.6.3.12	ko:K01547	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	-	E1-E2_ATPase,Hydrolase
REGS2_k127_5039604_2	1380394.JADL01000007_gene4503	6.044e-212	674.0	COG2060@1|root,COG2060@2|Bacteria,1MV1K@1224|Proteobacteria,2TSIJ@28211|Alphaproteobacteria,2JPJD@204441|Rhodospirillales	204441|Rhodospirillales	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane	kdpA	-	3.6.3.12	ko:K01546	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	-	KdpA
REGS2_k127_5039604_5	1535287.JP74_10315	8.536e-67	234.0	COG0745@1|root,COG0745@2|Bacteria,1MWZ5@1224|Proteobacteria,2TV3A@28211|Alphaproteobacteria,3N8C7@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Transcriptional regulatory protein, C terminal	kdpE	-	-	ko:K07667	ko02020,ko02024,map02020,map02024	M00454	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
REGS2_k127_5039604_6	525904.Tter_2066	2.535e-57	219.0	COG0642@1|root,COG2205@2|Bacteria,2NQXV@2323|unclassified Bacteria	525904.Tter_2066|-	T	PFAM ATP-binding region ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS2_k127_5039604_1	502558.EGYY_18690	5.587e-244	764.0	COG0441@1|root,COG0441@2|Bacteria,2GKTC@201174|Actinobacteria,4CUN7@84998|Coriobacteriia	84998|Coriobacteriia	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
REGS2_k127_5157889_12	552811.Dehly_0525	1.228e-14	82.0	COG0550@1|root,COG0550@2|Bacteria	2|Bacteria	L	DNA topoisomerase type I activity	topB	-	5.99.1.2	ko:K03169	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	DEAD,HRDC,Helicase_C,RecQ_Zn_bind,Topoisom_bac,Toprim,Toprim_Crpt
REGS2_k127_5157889_9	1235794.C811_00746	3.073e-18	94.0	COG4478@1|root,COG4478@2|Bacteria,2IFW4@201174|Actinobacteria,4CW7Q@84998|Coriobacteriia	84998|Coriobacteriia	S	Protein of unknown function (DUF1461)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1461
REGS2_k127_5157889_6	709986.Deima_0121	1.654e-28	129.0	COG2199@1|root,COG3706@2|Bacteria,1WI95@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	T	TIGRFAM diguanylate cyclase (GGDEF) domain	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,GGDEF,HisKA_7TM,PAS_4
REGS2_k127_5157889_5	742742.HMPREF9452_01998	7.992e-30	137.0	COG3266@1|root,COG3266@2|Bacteria,2I6AK@201174|Actinobacteria,4CVEE@84998|Coriobacteriia	84998|Coriobacteriia	S	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
REGS2_k127_5157889_13	526227.Mesil_0757	3.055e-13	83.0	COG2234@1|root,COG2234@2|Bacteria,1WIK7@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	PFAM Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
REGS2_k127_5157889_4	552811.Dehly_1564	6.183e-39	152.0	COG2337@1|root,COG2337@2|Bacteria	2|Bacteria	T	Toxic component of a toxin-antitoxin (TA) module	chpA	-	-	ko:K07171	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
REGS2_k127_5157889_14	1496688.ER33_07385	5.092e-12	72.0	COG2336@1|root,COG2336@2|Bacteria,1G9M5@1117|Cyanobacteria	1117|Cyanobacteria	T	PFAM SpoVT AbrB like domain	-	-	-	ko:K07172	-	-	-	-	ko00000,ko02048	-	-	-	MazE_antitoxin
REGS2_k127_5157889_0	1125863.JAFN01000001_gene1482	1.231e-230	728.0	COG0369@1|root,COG1151@2|Bacteria,1N88B@1224|Proteobacteria,42M2C@68525|delta/epsilon subdivisions,2WIVE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O	hcp	-	1.7.99.1	ko:K05601	ko00910,map00910	-	R00143	RC02797	ko00000,ko00001,ko01000	-	-	-	Prismane
REGS2_k127_5157889_2	1121430.JMLG01000008_gene1538	3.172e-55	195.0	COG1149@1|root,COG1149@2|Bacteria,1VUEG@1239|Firmicutes,2503A@186801|Clostridia,267CF@186807|Peptococcaceae	186801|Clostridia	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_21,Fer4_6
REGS2_k127_5157889_11	1121918.ARWE01000001_gene1373	1.218e-14	79.0	2EU5A@1|root,33MMY@2|Bacteria,1NE4I@1224|Proteobacteria,42WER@68525|delta/epsilon subdivisions,2WRAE@28221|Deltaproteobacteria,43VD3@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Nitrous oxide-stimulated promoter	-	-	-	-	-	-	-	-	-	-	-	-	YgbA_NO
REGS2_k127_5157889_8	240292.Ava_3187	1.036e-19	103.0	COG0664@1|root,COG0664@2|Bacteria,1G3SU@1117|Cyanobacteria,1HRGH@1161|Nostocales	1117|Cyanobacteria	K	helix_turn_helix, cAMP Regulatory protein	-	-	-	ko:K21563	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
REGS2_k127_5157889_15	485913.Krac_11890	5.679e-08	63.0	2A1JS@1|root,30PTP@2|Bacteria,2G9H1@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS2_k127_5157889_3	1144275.COCOR_07649	2.487e-46	187.0	COG5002@1|root,COG5002@2|Bacteria,1R2QY@1224|Proteobacteria,43DG8@68525|delta/epsilon subdivisions,2X8N6@28221|Deltaproteobacteria,2Z3MZ@29|Myxococcales	28221|Deltaproteobacteria	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
REGS2_k127_5157889_7	1122611.KB904018_gene6993	8.79e-26	119.0	COG2378@1|root,COG2378@2|Bacteria,2GM46@201174|Actinobacteria,4EFRP@85012|Streptosporangiales	201174|Actinobacteria	K	WYL domain	pafB	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	ko:K13572,ko:K13573	-	-	-	-	ko00000,ko03051	-	-	-	WYL
REGS2_k127_5157889_10	526225.Gobs_2687	4.109e-16	91.0	COG2378@1|root,COG2378@2|Bacteria,2GMAU@201174|Actinobacteria,4ESDG@85013|Frankiales	201174|Actinobacteria	K	WYL domain	pafC	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	ko:K13573	-	-	-	-	ko00000,ko03051	-	-	-	WYL
REGS2_k127_5157889_1	521003.COLINT_03263	1.274e-226	735.0	COG1199@1|root,COG2176@1|root,COG1199@2|Bacteria,COG2176@2|Bacteria,2GKT8@201174|Actinobacteria,4CUMF@84998|Coriobacteriia	84998|Coriobacteriia	L	DnaQ family exonuclease DinG family helicase	-	-	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Helicase_C_2,RNase_T
REGS2_k127_5207047_33	589924.Ferp_1979	2.604e-12	76.0	COG2033@1|root,arCOG02146@2157|Archaea,2XXQW@28890|Euryarchaeota,246JB@183980|Archaeoglobi	183980|Archaeoglobi	C	Desulfoferrodoxin	-	-	1.15.1.2	ko:K05919	-	-	-	-	ko00000,ko01000	-	-	-	Desulfoferrodox
REGS2_k127_5207047_26	608538.HTH_0124	7.985e-37	146.0	COG1335@1|root,COG1335@2|Bacteria	2|Bacteria	Q	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	pncA	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
REGS2_k127_5207047_3	405948.SACE_5619	4.903e-217	687.0	COG2759@1|root,COG2759@2|Bacteria,2GT0X@201174|Actinobacteria,4DXJB@85010|Pseudonocardiales	201174|Actinobacteria	F	Belongs to the formate--tetrahydrofolate ligase family	fhs	-	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
REGS2_k127_5207047_12	700015.Corgl_1158	1.966e-98	331.0	COG0190@1|root,COG0190@2|Bacteria,2GJZS@201174|Actinobacteria,4CV1K@84998|Coriobacteriia	84998|Coriobacteriia	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	-	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
REGS2_k127_5207047_24	2074.JNYD01000019_gene2563	1.863e-37	154.0	COG2020@1|root,COG2119@1|root,COG2020@2|Bacteria,COG2119@2|Bacteria,2GNR0@201174|Actinobacteria,4E1CT@85010|Pseudonocardiales	201174|Actinobacteria	O	Uncharacterized protein family UPF0016	-	-	-	-	-	-	-	-	-	-	-	-	UPF0016
REGS2_k127_5207047_19	742818.HMPREF9451_00197	1.256e-54	198.0	COG1636@1|root,COG1636@2|Bacteria,2HUPA@201174|Actinobacteria,4CVA0@84998|Coriobacteriia	84998|Coriobacteriia	C	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)	queH	-	1.17.99.6	ko:K09765	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF208
REGS2_k127_5207047_22	324602.Caur_3001	5.002e-40	158.0	COG0613@1|root,COG0613@2|Bacteria,2G74N@200795|Chloroflexi,37789@32061|Chloroflexia	32061|Chloroflexia	S	SMART phosphoesterase PHP domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PHP,PHP_C
REGS2_k127_5207047_10	292459.STH1165	5.329e-117	385.0	COG0809@1|root,COG0809@2|Bacteria,1TPKD@1239|Firmicutes,247NT@186801|Clostridia	186801|Clostridia	J	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	queA	-	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
REGS2_k127_5207047_29	1463845.JOIG01000005_gene3400	1.85e-27	119.0	COG1595@1|root,COG1595@2|Bacteria,2GJMX@201174|Actinobacteria	201174|Actinobacteria	K	belongs to the sigma-70 factor family, ECF subfamily	sigM	GO:0001101,GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0009410,GO:0009415,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0010035,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0042221,GO:0044464,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1901700,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
REGS2_k127_5207047_9	266117.Rxyl_1330	2.675e-127	431.0	COG0343@1|root,COG0343@2|Bacteria,2GMWY@201174|Actinobacteria,4CPB3@84995|Rubrobacteria	84995|Rubrobacteria	J	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
REGS2_k127_5207047_32	1144275.COCOR_02705	1.731e-13	74.0	COG1862@1|root,COG1862@2|Bacteria,1MZT2@1224|Proteobacteria,42V1U@68525|delta/epsilon subdivisions,2WR76@28221|Deltaproteobacteria,2Z26G@29|Myxococcales	28221|Deltaproteobacteria	U	Preprotein translocase subunit	yajC	-	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
REGS2_k127_5207047_15	429009.Adeg_1273	6.175e-76	262.0	COG3294@1|root,COG3294@2|Bacteria,1UXSS@1239|Firmicutes,24A8Y@186801|Clostridia,42FRF@68295|Thermoanaerobacterales	186801|Clostridia	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K09163	-	-	-	-	ko00000	-	-	-	HD
REGS2_k127_5207047_11	1111121.HMPREF1247_0185	1.965e-112	377.0	COG0342@1|root,COG0342@2|Bacteria,2GJTT@201174|Actinobacteria,4CUSY@84998|Coriobacteriia	84998|Coriobacteriia	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072,ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
REGS2_k127_5207047_14	479437.Elen_0984	4.421e-85	291.0	COG0341@1|root,COG0342@1|root,COG0341@2|Bacteria,COG0342@2|Bacteria,2GJTT@201174|Actinobacteria,4CUSY@84998|Coriobacteriia	84998|Coriobacteriia	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072,ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
REGS2_k127_5207047_0	661087.HMPREF1008_01721	0.0	1086.0	COG0514@1|root,COG0608@1|root,COG0514@2|Bacteria,COG0608@2|Bacteria,2IK2U@201174|Actinobacteria,4CUF5@84998|Coriobacteriia	84998|Coriobacteriia	L	single-stranded-DNA-specific exonuclease RecJ	recJ	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,DHH,DHHA1,Helicase_C
REGS2_k127_5207047_2	502558.EGYY_25940	3.017e-275	868.0	COG0317@1|root,COG0317@2|Bacteria,2GJYQ@201174|Actinobacteria,4CUQT@84998|Coriobacteriia	84998|Coriobacteriia	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
REGS2_k127_5207047_20	926567.TheveDRAFT_0552	1.633e-54	198.0	COG0491@1|root,COG0491@2|Bacteria,3TAUB@508458|Synergistetes	508458|Synergistetes	S	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
REGS2_k127_5207047_7	748247.AZKH_0382	8.745e-156	514.0	COG0318@1|root,COG0318@2|Bacteria	2|Bacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	LuxE
REGS2_k127_5207047_30	626939.HMPREF9443_00156	1.665e-21	98.0	COG0239@1|root,COG0239@2|Bacteria,1VEH7@1239|Firmicutes,4H4YH@909932|Negativicutes	909932|Negativicutes	D	Important for reducing fluoride concentration in the cell, thus reducing its toxicity	crcB	-	-	ko:K06199	-	-	-	-	ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3	-	-	CRCB
REGS2_k127_5207047_8	742818.HMPREF9451_01393	7.958e-150	490.0	COG0124@1|root,COG0124@2|Bacteria,2GIYJ@201174|Actinobacteria,4CV2W@84998|Coriobacteriia	84998|Coriobacteriia	J	histidyl-tRNA synthetase	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA-synt_His
REGS2_k127_5207047_4	502558.EGYY_08050	9.982e-216	686.0	COG0173@1|root,COG0173@2|Bacteria,2GJHU@201174|Actinobacteria,4CUY4@84998|Coriobacteriia	84998|Coriobacteriia	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
REGS2_k127_5207047_6	479437.Elen_2558	1.554e-171	548.0	COG2256@1|root,COG2256@2|Bacteria,2GKDP@201174|Actinobacteria,4CUTC@84998|Coriobacteriia	84998|Coriobacteriia	L	PFAM AAA ATPase central domain protein	-	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
REGS2_k127_5207047_34	1123319.AUBE01000017_gene4647	3.341e-06	55.0	COG4768@1|root,COG4768@2|Bacteria,2II1J@201174|Actinobacteria	201174|Actinobacteria	S	Bacterial protein of unknown function (DUF948)	-	-	-	-	-	-	-	-	-	-	-	-	DUF948
REGS2_k127_5207047_13	1111121.HMPREF1247_1478	4.532e-87	295.0	COG1191@1|root,COG1191@2|Bacteria,2GKSY@201174|Actinobacteria,4CUM2@84998|Coriobacteriia	84998|Coriobacteriia	K	RNA polymerase sigma-70 factor, sigma-B F G subfamily	-	-	-	ko:K03090	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r3,Sigma70_r4
REGS2_k127_5207047_21	502558.EGYY_04630	8.843e-46	182.0	COG0628@1|root,COG0628@2|Bacteria,2GN4Y@201174|Actinobacteria,4CU8I@84998|Coriobacteriia	84998|Coriobacteriia	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
REGS2_k127_5207047_1	1034345.CAEM01000025_gene1104	3.654e-292	921.0	COG0013@1|root,COG0013@2|Bacteria,2GIUG@201174|Actinobacteria,4CV1V@84998|Coriobacteriia	84998|Coriobacteriia	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
REGS2_k127_5207047_28	1504822.CCNO01000014_gene1107	1.262e-30	138.0	COG0816@1|root,COG0816@2|Bacteria	2|Bacteria	L	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA	yqgF	GO:0000966,GO:0000967,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008296,GO:0008408,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0140097,GO:1901360	-	ko:K07447	-	-	-	-	ko00000,ko01000	-	-	-	RuvX
REGS2_k127_5207047_17	1120973.AQXL01000135_gene1408	2.332e-64	242.0	COG1559@1|root,COG1559@2|Bacteria,1TS48@1239|Firmicutes,4HAUV@91061|Bacilli,279CC@186823|Alicyclobacillaceae	91061|Bacilli	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
REGS2_k127_5207047_16	404589.Anae109_0681	2.132e-64	246.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,42NSM@68525|delta/epsilon subdivisions,2WJXQ@28221|Deltaproteobacteria,2YXY8@29|Myxococcales	28221|Deltaproteobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	pilH	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
REGS2_k127_5207047_35	1396141.BATP01000027_gene1150	5.058e-06	57.0	COG1277@1|root,COG1277@2|Bacteria,46VKD@74201|Verrucomicrobia,2IUKU@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	ABC-type transport system involved in multi-copper enzyme maturation permease component	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_2
REGS2_k127_5207047_23	742818.HMPREF9451_01183	4.305e-39	152.0	COG2179@1|root,COG2179@2|Bacteria,2HTFS@201174|Actinobacteria,4CVXP@84998|Coriobacteriia	84998|Coriobacteriia	S	HAD superfamily (Subfamily IIIA) phosphatase, TIGR01668	yqeG	-	-	ko:K07015	-	-	-	-	ko00000	-	-	-	Hydrolase_like
REGS2_k127_5207047_18	926550.CLDAP_13020	8.457e-56	207.0	COG0169@1|root,COG0454@1|root,COG0169@2|Bacteria,COG0456@2|Bacteria,2G6FG@200795|Chloroflexi	200795|Chloroflexi	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	-	-	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_dh_N
REGS2_k127_5207047_5	590998.Celf_2007	2.67e-181	584.0	COG2804@1|root,COG2804@2|Bacteria,2I8C2@201174|Actinobacteria	201174|Actinobacteria	NU	type II secretion system protein E	pilB	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
REGS2_k127_5207047_27	326427.Cagg_3625	1.973e-32	134.0	COG2018@1|root,COG2018@2|Bacteria,2G8WW@200795|Chloroflexi,375M5@32061|Chloroflexia	32061|Chloroflexia	S	PFAM Roadblock LC7 family protein	-	-	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
REGS2_k127_5207047_25	357808.RoseRS_2140	7.185e-37	156.0	COG0457@1|root,COG0457@2|Bacteria,2G770@200795|Chloroflexi,374ST@32061|Chloroflexia	32061|Chloroflexia	S	Domain of unknown function (DUF4388)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4388
REGS2_k127_5428961_2	273068.TTE0639	6.561e-53	199.0	COG0697@1|root,COG0697@2|Bacteria,1TPUW@1239|Firmicutes,247X1@186801|Clostridia,42FMV@68295|Thermoanaerobacterales	186801|Clostridia	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
REGS2_k127_5428961_3	935866.JAER01000016_gene2091	1.632e-32	140.0	COG0799@1|root,COG0799@2|Bacteria,2IKZ3@201174|Actinobacteria,4DR96@85009|Propionibacteriales	201174|Actinobacteria	S	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation	rsfS	-	-	ko:K09710	-	-	-	-	ko00000,ko03009	-	-	-	RsfS
REGS2_k127_5428961_5	867903.ThesuDRAFT_00664	4.843e-06	59.0	COG1316@1|root,COG1316@2|Bacteria,1TR1B@1239|Firmicutes,24AAY@186801|Clostridia,3WD9K@538999|Clostridiales incertae sedis	186801|Clostridia	K	Cell envelope-related transcriptional attenuator domain	lytR	-	-	-	-	-	-	-	-	-	-	-	LytR_C,LytR_cpsA_psr
REGS2_k127_5428961_4	1122216.AUHW01000002_gene1781	1.1e-29	129.0	COG1713@1|root,COG1713@2|Bacteria,1V6Y1@1239|Firmicutes,4H4ES@909932|Negativicutes	909932|Negativicutes	H	Hydrolase HD family	-	-	-	-	-	-	-	-	-	-	-	-	HD
REGS2_k127_5428961_1	521003.COLINT_02379	2.065e-66	235.0	COG1057@1|root,COG1057@2|Bacteria,2GMFZ@201174|Actinobacteria,4CVT0@84998|Coriobacteriia	84998|Coriobacteriia	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	-	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like,HD
REGS2_k127_5428961_0	1121866.AUGK01000013_gene1918	5.543e-150	486.0	COG0014@1|root,COG0014@2|Bacteria,2GISA@201174|Actinobacteria,4CUMH@84998|Coriobacteriia	84998|Coriobacteriia	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate	proA	-	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
REGS2_k127_5495599_5	868595.Desca_2504	1.864e-47	176.0	COG2316@1|root,COG2316@2|Bacteria,1TSF7@1239|Firmicutes,24A1B@186801|Clostridia,260KY@186807|Peptococcaceae	186801|Clostridia	S	PFAM Metal-dependent phosphohydrolase, HD	-	-	-	ko:K06951	-	-	-	-	ko00000	-	-	-	HD
REGS2_k127_5495599_2	742818.HMPREF9451_00090	4.403e-89	303.0	COG0378@1|root,COG0378@2|Bacteria,2HP34@201174|Actinobacteria,4CVE2@84998|Coriobacteriia	84998|Coriobacteriia	KO	Hydrogenase accessory protein HypB	-	-	-	ko:K04652	-	-	-	-	ko00000,ko03110	-	-	-	cobW
REGS2_k127_5495599_7	479437.Elen_2830	4.648e-33	131.0	COG0375@1|root,COG0375@2|Bacteria,2IMJK@201174|Actinobacteria,4CWCV@84998|Coriobacteriia	84998|Coriobacteriia	S	Probably plays a role in a hydrogenase nickel cofactor insertion step	hypA	-	-	ko:K04651	-	-	-	-	ko00000,ko03110	-	-	-	HypA
REGS2_k127_5495599_3	1384484.AEQU_1586	1.305e-65	232.0	COG0805@1|root,COG0805@2|Bacteria,2GJK8@201174|Actinobacteria,4CV6F@84998|Coriobacteriia	84998|Coriobacteriia	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
REGS2_k127_5495599_11	1278073.MYSTI_06520	6.318e-09	62.0	COG1826@1|root,COG1826@2|Bacteria,1NI3F@1224|Proteobacteria	1224|Proteobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation	tatB	-	-	ko:K03116,ko:K03117	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
REGS2_k127_5495599_8	33876.JNXY01000005_gene8629	3.452e-25	111.0	COG1366@1|root,COG1366@2|Bacteria,2IHQG@201174|Actinobacteria,4DE05@85008|Micromonosporales	201174|Actinobacteria	T	Belongs to the anti-sigma-factor antagonist family	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS,STAS_2
REGS2_k127_5495599_12	395494.Galf_1027	1.854e-08	61.0	COG1366@1|root,COG1366@2|Bacteria,1MZ5N@1224|Proteobacteria,2VWS3@28216|Betaproteobacteria,44WKJ@713636|Nitrosomonadales	28216|Betaproteobacteria	T	STAS domain	-	-	-	ko:K20978	ko02020,ko02025,map02020,map02025	-	-	-	ko00000,ko00001	-	-	-	STAS_2
REGS2_k127_5495599_14	1121422.AUMW01000012_gene2997	6.24e-06	57.0	COG4235@1|root,COG4235@2|Bacteria	2|Bacteria	O	cytochrome complex assembly	-	-	-	ko:K02200,ko:K04018	-	-	-	-	ko00000	-	-	-	TPR_16,TPR_19,TPR_2,TPR_8
REGS2_k127_5495599_13	697281.Mahau_0937	2.145e-06	61.0	COG3086@1|root,COG3086@2|Bacteria,1VEYP@1239|Firmicutes,24R8Z@186801|Clostridia	186801|Clostridia	T	PFAM Positive regulator of sigma(E) RseC MucC	-	-	-	ko:K03803	-	-	-	-	ko00000,ko03021	-	-	-	RseC_MucC
REGS2_k127_5495599_1	502558.EGYY_26490	1.2e-127	422.0	COG0402@1|root,COG0402@2|Bacteria,2GM63@201174|Actinobacteria,4CV60@84998|Coriobacteriia	84998|Coriobacteriia	F	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
REGS2_k127_5495599_4	903818.KI912268_gene2908	2.502e-52	195.0	COG0500@1|root,COG2226@2|Bacteria,3Y44I@57723|Acidobacteria	57723|Acidobacteria	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)	menG	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
REGS2_k127_5495599_0	635013.TherJR_0239	2.501e-179	580.0	COG1032@1|root,COG1032@2|Bacteria,1UZQC@1239|Firmicutes,24PDA@186801|Clostridia	186801|Clostridia	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
REGS2_k127_5495599_6	478801.Ksed_03310	1.851e-38	150.0	2DM5T@1|root,31U0Y@2|Bacteria,2I89A@201174|Actinobacteria,1ZVY9@145357|Dermacoccaceae	201174|Actinobacteria	S	Domain of unknown function (DUF4126)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4126
REGS2_k127_5495599_9	1131730.BAVI_23939	5.642e-20	102.0	COG3005@1|root,COG3005@2|Bacteria,1UDA8@1239|Firmicutes,4IJM5@91061|Bacilli,1ZBCA@1386|Bacillus	91061|Bacilli	C	denitrification pathway	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_NNT
REGS2_k127_5495599_10	871968.DESME_09175	1.312e-09	70.0	COG3005@1|root,COG3005@2|Bacteria,1VTRU@1239|Firmicutes,2500S@186801|Clostridia,264IC@186807|Peptococcaceae	186801|Clostridia	C	denitrification pathway	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS2_k127_5528375_10	1035308.AQYY01000001_gene1984	1.043e-23	105.0	COG0697@1|root,COG0697@2|Bacteria,1TRKE@1239|Firmicutes,249RU@186801|Clostridia,2631B@186807|Peptococcaceae	186801|Clostridia	EG	DMT(Drug metabolite transporter) superfamily permease	-	-	-	-	-	-	-	-	-	-	-	-	EamA
REGS2_k127_5528375_6	398512.JQKC01000005_gene5620	4.822e-40	165.0	COG4908@1|root,COG4908@2|Bacteria,1V0U5@1239|Firmicutes,25D3E@186801|Clostridia,3WK8S@541000|Ruminococcaceae	186801|Clostridia	S	Condensation domain	-	-	-	-	-	-	-	-	-	-	-	-	Condensation
REGS2_k127_5528375_4	414684.RC1_0575	2.49e-52	192.0	COG0847@1|root,COG0847@2|Bacteria,1R7J9@1224|Proteobacteria,2U8ZN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases	-	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	BRCT,RNase_T
REGS2_k127_5528375_11	1278078.G419_20870	4.712e-15	79.0	COG0346@1|root,COG0346@2|Bacteria,2GT0D@201174|Actinobacteria	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
REGS2_k127_5528375_3	118166.JH976537_gene2787	7.452e-91	320.0	COG0053@1|root,COG0053@2|Bacteria,1G361@1117|Cyanobacteria,1HE5W@1150|Oscillatoriales	1117|Cyanobacteria	P	TIGRFAM cation diffusion facilitator family transporter	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
REGS2_k127_5528375_5	1245475.ANAE01000169_gene1817	4.557e-41	161.0	COG2197@1|root,COG2197@2|Bacteria,2GJRY@201174|Actinobacteria,4EIZZ@85012|Streptosporangiales	201174|Actinobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
REGS2_k127_5528375_8	649638.Trad_0777	6.276e-28	130.0	COG2203@1|root,COG4585@1|root,COG2203@2|Bacteria,COG4585@2|Bacteria,1WIV0@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,GAF_3,HATPase_c,HisKA_3
REGS2_k127_5528375_9	85643.Tmz1t_2631	9.863e-25	120.0	COG3850@1|root,COG3850@2|Bacteria,1MWZT@1224|Proteobacteria,2VIFM@28216|Betaproteobacteria,2KV4T@206389|Rhodocyclales	206389|Rhodocyclales	T	Type IV pili methyl-accepting chemotaxis transducer N-term	-	-	2.7.13.3	ko:K07673	ko02020,map02020	M00471	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	GAF_2,HAMP,HATPase_c,HisKA_3,PilJ
REGS2_k127_5528375_12	688269.Theth_1349	3.436e-14	81.0	COG1669@1|root,COG1669@2|Bacteria,2GDMT@200918|Thermotogae	200918|Thermotogae	L	PFAM DNA polymerase, beta domain protein region	-	-	-	ko:K07075	-	-	-	-	ko00000	-	-	-	NTP_transf_2
REGS2_k127_5528375_0	1226994.AMZB01000134_gene4591	1.856e-189	606.0	COG0659@1|root,COG0659@2|Bacteria,1MVWV@1224|Proteobacteria,1RMCN@1236|Gammaproteobacteria,1YDFM@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	P	Sulfate permease family	ychM	GO:0003333,GO:0003674,GO:0005215,GO:0005310,GO:0005326,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0006835,GO:0006836,GO:0006855,GO:0006865,GO:0008150,GO:0008272,GO:0008509,GO:0008514,GO:0015075,GO:0015103,GO:0015116,GO:0015138,GO:0015141,GO:0015171,GO:0015172,GO:0015179,GO:0015183,GO:0015238,GO:0015318,GO:0015556,GO:0015698,GO:0015711,GO:0015740,GO:0015741,GO:0015744,GO:0015800,GO:0015807,GO:0015810,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0070778,GO:0071422,GO:0071702,GO:0071705,GO:0071944,GO:0072348,GO:0098656,GO:0098660,GO:0098661,GO:1901682,GO:1902358,GO:1902475,GO:1903825,GO:1905039	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	iSbBS512_1146.SbBS512_E1370	STAS,Sulfate_transp
REGS2_k127_5528375_1	398512.JQKC01000004_gene5249	4.271e-118	411.0	COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,1UIEA@1239|Firmicutes,25EJM@186801|Clostridia,3WI29@541000|Ruminococcaceae	186801|Clostridia	GT	Pyruvate phosphate dikinase, PEP/pyruvate binding domain	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
REGS2_k127_5528375_2	1236541.BALL01000069_gene4832	1.577e-105	351.0	COG2313@1|root,COG2313@2|Bacteria,1MUQU@1224|Proteobacteria,1RQJH@1236|Gammaproteobacteria,2Q8I9@267890|Shewanellaceae	1236|Gammaproteobacteria	Q	Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway	psuG	GO:0001522,GO:0003674,GO:0003824,GO:0004730,GO:0005488,GO:0005515,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0016043,GO:0016070,GO:0016787,GO:0016798,GO:0016829,GO:0016835,GO:0016836,GO:0022607,GO:0030145,GO:0034641,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0046914,GO:0051259,GO:0051260,GO:0065003,GO:0070206,GO:0070207,GO:0071704,GO:0071840,GO:0090304,GO:1901360	4.2.1.70	ko:K16329	ko00240,map00240	-	R01055	RC00432,RC00433	ko00000,ko00001,ko01000	-	-	-	Indigoidine_A
REGS2_k127_5607462_8	1120948.KB903217_gene1409	5.692e-17	88.0	COG0345@1|root,COG0345@2|Bacteria,2GJ7D@201174|Actinobacteria,4DZE4@85010|Pseudonocardiales	201174|Actinobacteria	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	GO:0000287,GO:0003674,GO:0003824,GO:0004735,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0018130,GO:0019752,GO:0030145,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0046914,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_oxidored,P5CR_dimer
REGS2_k127_5607462_6	1122939.ATUD01000019_gene1540	9.705e-29	123.0	COG1799@1|root,COG1799@2|Bacteria,2GNVH@201174|Actinobacteria,4CQ0C@84995|Rubrobacteria	84995|Rubrobacteria	D	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA	sepF	-	-	ko:K09772	-	-	-	-	ko00000,ko03036	-	-	-	SepF
REGS2_k127_5607462_4	1121468.AUBR01000006_gene391	4.509e-52	196.0	COG0325@1|root,COG0325@2|Bacteria,1TRDN@1239|Firmicutes,248R6@186801|Clostridia,42G1Y@68295|Thermoanaerobacterales	186801|Clostridia	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis	ylmE	-	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
REGS2_k127_5607462_7	469383.Cwoe_4545	1.577e-28	124.0	COG0704@1|root,COG0704@2|Bacteria,2HGEG@201174|Actinobacteria,4CPTJ@84995|Rubrobacteria	84995|Rubrobacteria	P	Plays a role in the regulation of phosphate uptake	-	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
REGS2_k127_5607462_0	700015.Corgl_0771	1.76e-117	399.0	COG1117@1|root,COG1117@2|Bacteria,2GJQ3@201174|Actinobacteria,4CVB4@84998|Coriobacteriia	84998|Coriobacteriia	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	-	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
REGS2_k127_5607462_1	521003.COLINT_02157	2.193e-107	354.0	COG0581@1|root,COG0581@2|Bacteria,2I2F2@201174|Actinobacteria,4CVF9@84998|Coriobacteriia	84998|Coriobacteriia	P	Phosphate transport system permease protein PstA	pstA	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
REGS2_k127_5607462_2	742722.HMPREF9463_01330	4.286e-97	333.0	COG0573@1|root,COG0573@2|Bacteria,2GJDA@201174|Actinobacteria,4CVZG@84998|Coriobacteriia	84998|Coriobacteriia	P	probably responsible for the translocation of the substrate across the membrane	pstC	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
REGS2_k127_5607462_3	521003.COLINT_02155	1.736e-76	268.0	COG0226@1|root,COG0226@2|Bacteria,2GMY1@201174|Actinobacteria,4CW8U@84998|Coriobacteriia	84998|Coriobacteriia	P	phosphate binding protein	pstS	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
REGS2_k127_5607462_5	1504822.CCNO01000013_gene474	2.432e-47	183.0	COG1496@1|root,COG1496@2|Bacteria	2|Bacteria	S	copper ion binding	yfiH	GO:0003674,GO:0003824,GO:0005488,GO:0005507,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016679,GO:0016682,GO:0030312,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0046983,GO:0055114,GO:0071944	-	ko:K05810	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_4
REGS2_k127_5659017_3	42256.RradSPS_2877	3.887e-24	106.0	COG0640@1|root,COG0640@2|Bacteria,2IMIV@201174|Actinobacteria,4CQJJ@84995|Rubrobacteria	84995|Rubrobacteria	K	regulatory protein, arsR	-	-	-	ko:K21903	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
REGS2_k127_5659017_0	1122919.KB905585_gene3923	3.791e-173	566.0	COG2217@1|root,COG2217@2|Bacteria,1TQ07@1239|Firmicutes,4H9SP@91061|Bacilli,26QEF@186822|Paenibacillaceae	91061|Bacilli	P	COG2217 Cation transport ATPase	cadA	-	3.6.3.3,3.6.3.5	ko:K01534	-	-	-	-	ko00000,ko01000	3.A.3.6	-	-	E1-E2_ATPase,HMA,Hydrolase
REGS2_k127_5659017_2	1220589.CD32_16050	5.661e-52	191.0	COG3797@1|root,COG3797@2|Bacteria,1V426@1239|Firmicutes,4HI2S@91061|Bacilli,3IXNT@400634|Lysinibacillus	91061|Bacilli	S	Protein of unknown function (DUF1697)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1697
REGS2_k127_5659017_1	1173020.Cha6605_0968	6.219e-75	261.0	COG2267@1|root,COG2267@2|Bacteria,1G771@1117|Cyanobacteria	2|Bacteria	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Hydrolase_4
REGS2_k127_5680906_12	440512.C211_02101	8.486e-10	70.0	COG4447@1|root,COG4447@2|Bacteria,1RCNG@1224|Proteobacteria,1S1N2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	protein related to plant photosystem II stability assembly factor	-	-	-	-	-	-	-	-	-	-	-	-	PSII_BNR
REGS2_k127_5680906_9	246194.CHY_0604	5.025e-27	124.0	COG3005@1|root,COG3005@2|Bacteria,1VBE7@1239|Firmicutes,2527F@186801|Clostridia	186801|Clostridia	C	NapC/NirT cytochrome c family, N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS2_k127_5680906_8	246194.CHY_0604	1.557e-31	139.0	COG3005@1|root,COG3005@2|Bacteria,1VBE7@1239|Firmicutes,2527F@186801|Clostridia	186801|Clostridia	C	NapC/NirT cytochrome c family, N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS2_k127_5680906_5	266117.Rxyl_0187	4.081e-62	221.0	COG0745@1|root,COG0745@2|Bacteria,2GMG9@201174|Actinobacteria,4CQ94@84995|Rubrobacteria	84995|Rubrobacteria	K	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
REGS2_k127_5680906_6	469383.Cwoe_4709	1.381e-52	204.0	COG2770@1|root,COG5002@1|root,COG2770@2|Bacteria,COG5002@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	cpxA	-	2.7.13.3	ko:K02484,ko:K07640,ko:K07643,ko:K07645,ko:K07649,ko:K19609	ko01503,ko02020,ko02024,map01503,map02020,map02024	M00447,M00451,M00453,M00457,M00721,M00722,M00727,M00728,M00770	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	2CSK_N,CpxA_peri,HAMP,HATPase_c,HK_sensor,HisKA
REGS2_k127_5680906_0	479437.Elen_1693	5.803e-177	574.0	COG3276@1|root,COG3276@2|Bacteria,2GKF9@201174|Actinobacteria,4CU7A@84998|Coriobacteriia	84998|Coriobacteriia	J	Elongation factor SelB winged helix	-	-	-	ko:K03833	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,SelB-wing_2,SelB-wing_3
REGS2_k127_5680906_1	477974.Daud_1093	1.409e-138	455.0	COG1921@1|root,COG1921@2|Bacteria,1TQT8@1239|Firmicutes,2498U@186801|Clostridia,2608U@186807|Peptococcaceae	186801|Clostridia	J	Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis	selA	-	2.9.1.1	ko:K01042	ko00450,ko00970,map00450,map00970	-	R08219	RC01246	ko00000,ko00001,ko01000	-	-	-	Se-cys_synth_N,SelA
REGS2_k127_5680906_10	1504822.CCNO01000011_gene31	2.797e-25	109.0	COG0425@1|root,COG0425@2|Bacteria,2NQ1J@2323|unclassified Bacteria	2|Bacteria	O	DsrE/DsrF-like family	yedF	-	-	-	-	-	-	-	-	-	-	-	DrsE,TusA
REGS2_k127_5680906_2	469378.Ccur_11290	6.288e-104	347.0	COG0709@1|root,COG0709@2|Bacteria,2GNP4@201174|Actinobacteria,4CUXI@84998|Coriobacteriia	84998|Coriobacteriia	H	Synthesizes selenophosphate from selenide and ATP	selD	-	2.7.9.3	ko:K01008	ko00450,ko01100,map00450,map01100	-	R03595	RC00002,RC02878	ko00000,ko00001,ko01000,ko03016	-	-	-	AIRS,AIRS_C
REGS2_k127_5680906_3	574087.Acear_0860	6.727e-73	267.0	COG0517@1|root,COG2199@1|root,COG2200@1|root,COG0517@2|Bacteria,COG2199@2|Bacteria,COG2200@2|Bacteria,1TQ94@1239|Firmicutes,248BK@186801|Clostridia	186801|Clostridia	T	PFAM EAL domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,EAL,GGDEF
REGS2_k127_5680906_7	644966.Tmar_1534	6.735e-47	192.0	COG1874@1|root,COG3934@1|root,COG1874@2|Bacteria,COG3934@2|Bacteria,1UEWM@1239|Firmicutes,24AQC@186801|Clostridia	186801|Clostridia	G	Belongs to the glycosyl hydrolase 5 (cellulase A) family	-	-	3.2.1.23	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	-	R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000	-	-	-	Cellulase,Glyco_hydro_42M
REGS2_k127_5680906_14	96561.Dole_2418	2.291e-09	70.0	COG0457@1|root,COG0457@2|Bacteria,1NFQW@1224|Proteobacteria,42MT2@68525|delta/epsilon subdivisions,2WKWA@28221|Deltaproteobacteria,2MJFK@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_2,TPR_4,TPR_8
REGS2_k127_5680906_13	1125863.JAFN01000001_gene3059	2.221e-09	70.0	COG5012@1|root,COG5012@2|Bacteria,1RDEU@1224|Proteobacteria,43BR3@68525|delta/epsilon subdivisions,2X809@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Methionine synthase B12-binding module cap domain protein	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,B12-binding_2
REGS2_k127_5680906_4	502558.EGYY_22270	7.861e-65	233.0	COG0248@1|root,COG0248@2|Bacteria,2GJBN@201174|Actinobacteria,4CUUZ@84998|Coriobacteriia	84998|Coriobacteriia	FP	Ppx GppA phosphatase	-	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	Ppx-GppA
REGS2_k127_5680906_11	1120950.KB892752_gene6172	2.775e-20	101.0	COG1507@1|root,COG1507@2|Bacteria,2I8CS@201174|Actinobacteria,4DQUA@85009|Propionibacteriales	201174|Actinobacteria	S	Protein of unknown function (DUF501)	-	-	-	ko:K09009	-	-	-	-	ko00000	-	-	-	DUF501
REGS2_k127_5680906_15	266117.Rxyl_0914	3.739e-08	59.0	COG2919@1|root,COG2919@2|Bacteria	2|Bacteria	D	cell cycle	divIC	-	-	ko:K05589,ko:K12065,ko:K13052	-	-	-	-	ko00000,ko02044,ko03036	3.A.7.11.1	-	-	DivIC
REGS2_k127_569081_23	498761.HM1_2091	1.184e-35	139.0	COG0345@1|root,COG0345@2|Bacteria,1TP1E@1239|Firmicutes,247SR@186801|Clostridia	186801|Clostridia	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	-	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_oxidored,P5CR_dimer
REGS2_k127_569081_35	1232436.CAPF01000020_gene1019	4.217e-05	53.0	COG0762@1|root,COG0762@2|Bacteria,2HV8G@201174|Actinobacteria,4CWGW@84998|Coriobacteriia	84998|Coriobacteriia	S	YGGT family	-	-	-	ko:K02221	-	-	-	-	ko00000,ko02044	-	-	-	YGGT
REGS2_k127_569081_28	401526.TcarDRAFT_0573	1.256e-27	123.0	COG3599@1|root,COG3599@2|Bacteria,1V27M@1239|Firmicutes,4H4TH@909932|Negativicutes	909932|Negativicutes	D	DivIVA domain protein	divIVA	-	-	ko:K04074	-	-	-	-	ko00000,ko03036	-	-	-	DivIVA
REGS2_k127_569081_31	1096546.WYO_2197	1.459e-15	86.0	COG1872@1|root,COG1872@2|Bacteria,1PMW3@1224|Proteobacteria,2V0GI@28211|Alphaproteobacteria,1JVYA@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	DUF167	-	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
REGS2_k127_569081_1	502558.EGYY_14810	0.0	1090.0	COG0060@1|root,COG0060@2|Bacteria,2GK9M@201174|Actinobacteria,4CUMK@84998|Coriobacteriia	84998|Coriobacteriia	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
REGS2_k127_569081_30	479435.Kfla_2896	6.71e-19	94.0	COG1734@1|root,COG1734@2|Bacteria,2GJBE@201174|Actinobacteria,4DR4Q@85009|Propionibacteriales	201174|Actinobacteria	T	Prokaryotic dksA/traR C4-type zinc finger	-	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
REGS2_k127_569081_29	370438.PTH_1819	2.21e-25	112.0	COG0597@1|root,COG0597@2|Bacteria,1VA9R@1239|Firmicutes,24QPP@186801|Clostridia,262DS@186807|Peptococcaceae	186801|Clostridia	MU	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	lspA	-	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
REGS2_k127_569081_22	643648.Slip_0562	1.285e-38	156.0	COG0682@1|root,COG0682@2|Bacteria,1TPAK@1239|Firmicutes,24BK7@186801|Clostridia,42K2Z@68298|Syntrophomonadaceae	186801|Clostridia	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
REGS2_k127_569081_6	742722.HMPREF9463_01488	2.385e-105	358.0	COG0564@1|root,COG0564@2|Bacteria,2GIY1@201174|Actinobacteria,4CUMJ@84998|Coriobacteriia	84998|Coriobacteriia	J	Responsible for synthesis of pseudouridine from uracil	-	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
REGS2_k127_569081_16	1415778.JQMM01000001_gene2125	5.951e-67	244.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1S5BV@1236|Gammaproteobacteria,1J8NN@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	CHASE,HATPase_c,HisKA,MASE1
REGS2_k127_569081_24	269799.Gmet_2789	1.638e-35	139.0	COG0745@1|root,COG0745@2|Bacteria,1RD7E@1224|Proteobacteria,42T3B@68525|delta/epsilon subdivisions,2WP8H@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	cheY-homologous receiver domain	-	-	-	ko:K11443	ko02020,ko04112,map02020,map04112	M00511	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg
REGS2_k127_569081_19	1304885.AUEY01000045_gene255	1.515e-54	213.0	COG3437@1|root,COG4191@1|root,COG3437@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42M1R@68525|delta/epsilon subdivisions,2WK3J@28221|Deltaproteobacteria,2MI5F@213118|Desulfobacterales	28221|Deltaproteobacteria	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
REGS2_k127_569081_9	471855.Shel_00330	2.065e-96	341.0	COG0745@1|root,COG0745@2|Bacteria,2GMP1@201174|Actinobacteria,4CYGQ@84998|Coriobacteriia	84998|Coriobacteriia	K	response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
REGS2_k127_569081_11	1034345.CAEM01000008_gene1262	2.719e-87	314.0	COG0642@1|root,COG2205@2|Bacteria,2I2QY@201174|Actinobacteria,4CUCM@84998|Coriobacteriia	84998|Coriobacteriia	T	ATPase histidine kinase DNA gyrase B HSP90 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
REGS2_k127_569081_13	742818.HMPREF9451_00981	1.681e-70	246.0	COG2065@1|root,COG2065@2|Bacteria,2GJNP@201174|Actinobacteria,4CUFE@84998|Coriobacteriia	84998|Coriobacteriia	F	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant	pyrR	-	2.4.2.9	ko:K02825	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000,ko03000	-	-	-	Pribosyltran
REGS2_k127_569081_7	1321773.HMPREF9069_01858	9.286e-103	348.0	COG0540@1|root,COG0540@2|Bacteria,2GKNA@201174|Actinobacteria,4CUP8@84998|Coriobacteriia	84998|Coriobacteriia	F	Belongs to the ATCase OTCase family	pyrB	-	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
REGS2_k127_569081_2	1034345.CAEM01000019_gene1712	8.044e-156	504.0	COG0044@1|root,COG0044@2|Bacteria,2GJ0T@201174|Actinobacteria,4CU8N@84998|Coriobacteriia	84998|Coriobacteriia	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	pyrC	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
REGS2_k127_569081_3	502558.EGYY_14690	2.889e-139	461.0	COG0505@1|root,COG0505@2|Bacteria,2GKFA@201174|Actinobacteria,4CVCQ@84998|Coriobacteriia	84998|Coriobacteriia	F	Belongs to the CarA family	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
REGS2_k127_569081_32	1230460.C495_11914	3.075e-10	70.0	COG0589@1|root,arCOG00449@2157|Archaea,2XVAF@28890|Euryarchaeota,23UZU@183963|Halobacteria	183963|Halobacteria	T	COG0589 Universal stress protein UspA and related nucleotide-binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Usp
REGS2_k127_569081_0	479437.Elen_1670	0.0	1489.0	COG0458@1|root,COG0458@2|Bacteria,2GK5N@201174|Actinobacteria,4CUHZ@84998|Coriobacteriia	84998|Coriobacteriia	F	Belongs to the CarB family	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
REGS2_k127_569081_15	469378.Ccur_07840	1.336e-67	242.0	COG0543@1|root,COG0543@2|Bacteria,2HQ24@201174|Actinobacteria,4CV6M@84998|Coriobacteriia	84998|Coriobacteriia	C	Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( )	pyrK	-	-	ko:K02823	ko00240,ko01100,map00240,map01100	-	-	-	ko00000,ko00001	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
REGS2_k127_569081_4	742818.HMPREF9451_00977	5.751e-117	385.0	COG0167@1|root,COG0167@2|Bacteria,2GKC6@201174|Actinobacteria,4CUEZ@84998|Coriobacteriia	84998|Coriobacteriia	F	Catalyzes the conversion of dihydroorotate to orotate	pyrD	-	1.3.1.14	ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
REGS2_k127_569081_14	1232436.CAPF01000016_gene626	1.21e-68	240.0	COG0284@1|root,COG0284@2|Bacteria,2IPX2@201174|Actinobacteria,4CV9H@84998|Coriobacteriia	84998|Coriobacteriia	F	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)	pyrF	-	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
REGS2_k127_569081_21	138119.DSY2855	7.892e-48	184.0	COG0461@1|root,COG0461@2|Bacteria,1V1BZ@1239|Firmicutes,25CGM@186801|Clostridia,261GR@186807|Peptococcaceae	186801|Clostridia	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
REGS2_k127_569081_27	1111121.HMPREF1247_1346	7.615e-28	117.0	COG0099@1|root,COG0099@2|Bacteria,2IKPU@201174|Actinobacteria,4CW7U@84998|Coriobacteriia	84998|Coriobacteriia	J	integration host factor	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS2_k127_569081_18	469378.Ccur_07800	3.48e-56	202.0	COG0194@1|root,COG0194@2|Bacteria,2GK2M@201174|Actinobacteria,4CVKY@84998|Coriobacteriia	84998|Coriobacteriia	F	Essential for recycling GMP and indirectly, cGMP	gmk	-	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
REGS2_k127_569081_33	443906.CMM_1779	1.351e-09	63.0	COG1758@1|root,COG1758@2|Bacteria,2IQHU@201174|Actinobacteria,4FPHE@85023|Microbacteriaceae	201174|Actinobacteria	K	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits	rpoZ	GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944	2.7.7.6	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
REGS2_k127_569081_5	1235794.C811_00659	1.068e-115	385.0	COG0301@1|root,COG0301@2|Bacteria,2GMFY@201174|Actinobacteria,4CU8T@84998|Coriobacteriia	84998|Coriobacteriia	H	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	thiI	-	2.8.1.4	ko:K03151	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07461	-	ko00000,ko00001,ko01000,ko03016	-	-	-	THUMP,ThiI
REGS2_k127_569081_12	1125863.JAFN01000001_gene836	2.974e-71	268.0	COG0438@1|root,COG0438@2|Bacteria,1NA28@1224|Proteobacteria,42NZA@68525|delta/epsilon subdivisions,2WK1T@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	DUF3524,Glycos_transf_1
REGS2_k127_569081_34	1273538.G159_08260	1.311e-06	56.0	2DQHB@1|root,336UW@2|Bacteria,1VJB2@1239|Firmicutes,4HNHK@91061|Bacilli,26GD1@186818|Planococcaceae	91061|Bacilli	S	Phospholipase_D-nuclease N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_N
REGS2_k127_569081_8	1349820.M707_09040	3.381e-101	344.0	COG1131@1|root,COG1131@2|Bacteria,2GKWB@201174|Actinobacteria	201174|Actinobacteria	V	abc transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,PLDc_N
REGS2_k127_569081_20	1349820.M707_09035	1.095e-53	205.0	COG1277@1|root,COG1277@2|Bacteria,2GRTV@201174|Actinobacteria	201174|Actinobacteria	S	ABC-type transport system involved in multi-copper enzyme maturation permease component	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
REGS2_k127_569081_26	387631.Asulf_00807	5.859e-29	127.0	COG1592@1|root,COG1633@1|root,arCOG01097@2157|Archaea,arCOG01102@2157|Archaea	2157|Archaea	C	Rubrerythrin	-	-	-	ko:K19824	-	-	-	-	ko00000	-	-	-	Rubrerythrin
REGS2_k127_569081_25	1123376.AUIU01000014_gene712	7.108e-34	136.0	COG0693@1|root,COG0693@2|Bacteria	2|Bacteria	S	protein deglycation	pfpI3	-	2.7.11.1,3.5.1.124	ko:K03152,ko:K05520,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001,ko01002	-	-	-	DJ-1_PfpI
REGS2_k127_569081_17	768710.DesyoDRAFT_4015	7.252e-60	228.0	COG0348@1|root,COG0348@2|Bacteria,1TPHF@1239|Firmicutes,24FW0@186801|Clostridia,263M2@186807|Peptococcaceae	186801|Clostridia	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_10,Fer4_5
REGS2_k127_569081_10	1347392.CCEZ01000018_gene1151	1.376e-94	324.0	COG0156@1|root,COG0156@2|Bacteria,1TPUX@1239|Firmicutes,2491D@186801|Clostridia,36DZ7@31979|Clostridiaceae	186801|Clostridia	E	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide	kbl	GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008710,GO:0008890,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.3.1.29	ko:K00639	ko00260,map00260	-	R00371	RC00004,RC00394	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
REGS2_k127_5756491_1	386456.JQKN01000003_gene390	5.319e-36	158.0	arCOG07791@1|root,arCOG07791@2157|Archaea,2XYMJ@28890|Euryarchaeota,23P2R@183925|Methanobacteria	183925|Methanobacteria	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
REGS2_k127_5756491_0	1128421.JAGA01000003_gene3382	6.555e-84	297.0	COG1215@1|root,COG1215@2|Bacteria,2NPD4@2323|unclassified Bacteria	2|Bacteria	M	PFAM Glycosyl transferase family 2	icaA	-	-	ko:K11936	ko02026,map02026	-	-	-	ko00000,ko00001,ko01000,ko01003,ko02000	4.D.1.1.2,4.D.1.1.3	GT2	-	Glyco_tranf_2_3,Glycos_transf_2
REGS2_k127_5756491_3	335541.Swol_2159	1.18e-16	91.0	290YK@1|root,2ZNKB@2|Bacteria,1V5MF@1239|Firmicutes,24HIN@186801|Clostridia	186801|Clostridia	S	Transmembrane exosortase (Exosortase_EpsH)	-	-	-	-	-	-	-	-	-	-	-	-	Exosortase_EpsH
REGS2_k127_5756491_4	1330700.JQNC01000003_gene722	8.883e-13	83.0	COG1470@1|root,COG4719@1|root,COG1470@2|Bacteria,COG4719@2|Bacteria,1WJNZ@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Domain of unknown function DUF11	-	-	-	-	-	-	-	-	-	-	-	-	DUF11
REGS2_k127_5756491_2	390989.JOEG01000007_gene596	6.203e-26	118.0	COG2199@1|root,COG3706@2|Bacteria,2IABQ@201174|Actinobacteria,4D9W3@85008|Micromonosporales	201174|Actinobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Response_reg
REGS2_k127_5756491_5	1122237.AUGQ01000017_gene2448	2.753e-06	59.0	COG1361@1|root,COG1361@2|Bacteria,2HZGC@201174|Actinobacteria,4FNVG@85023|Microbacteriaceae	201174|Actinobacteria	M	Bacterial protein of unknown function (DUF916)	-	-	-	-	-	-	-	-	-	-	-	-	DUF916
REGS2_k127_5808391_5	1304865.JAGF01000001_gene3406	3.909e-52	189.0	COG2376@1|root,COG2376@2|Bacteria,2GJV9@201174|Actinobacteria,4F0V3@85016|Cellulomonadaceae	201174|Actinobacteria	G	PFAM Dak kinase	dhaK2	GO:0003674,GO:0003824,GO:0005488,GO:0005975,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009056,GO:0009743,GO:0009758,GO:0009987,GO:0010033,GO:0016052,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0019200,GO:0030246,GO:0042221,GO:0044237,GO:0044238,GO:0044262,GO:0046835,GO:0050896,GO:0051716,GO:0070887,GO:0071310,GO:0071322,GO:0071704,GO:1901575,GO:1901700,GO:1901701	2.7.1.121,2.7.1.210,2.7.1.28,2.7.1.29,4.6.1.15	ko:K00863,ko:K05878,ko:K20902	ko00051,ko00561,ko00680,ko01100,ko01120,ko01200,ko04622,map00051,map00561,map00680,map01100,map01120,map01200,map04622	M00344	R01011,R01012,R01059,R11461	RC00002,RC00015,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Dak1,Dak2
REGS2_k127_5808391_4	1206744.BAGL01000122_gene3086	3.143e-63	229.0	COG0698@1|root,COG0698@2|Bacteria,2IIDQ@201174|Actinobacteria,4G1FU@85025|Nocardiaceae	201174|Actinobacteria	G	Ribose/Galactose Isomerase	-	GO:0003674,GO:0003824,GO:0005975,GO:0008150,GO:0008152,GO:0009056,GO:0009743,GO:0009758,GO:0009987,GO:0010033,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0042221,GO:0044238,GO:0050896,GO:0051716,GO:0070887,GO:0071310,GO:0071322,GO:0071704,GO:1901575,GO:1901700,GO:1901701	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	LacAB_rpiB
REGS2_k127_5808391_2	1304865.JAGF01000001_gene3404	1.482e-102	340.0	COG1028@1|root,COG1028@2|Bacteria,2GK20@201174|Actinobacteria	201174|Actinobacteria	IQ	Short-chain dehydrogenase reductase sdr	-	GO:0003674,GO:0003824,GO:0005488,GO:0005975,GO:0008150,GO:0008152,GO:0009056,GO:0009743,GO:0009758,GO:0009987,GO:0010033,GO:0016052,GO:0016491,GO:0016614,GO:0016616,GO:0030246,GO:0042221,GO:0044238,GO:0047880,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071310,GO:0071322,GO:0071704,GO:1901575,GO:1901700,GO:1901701	1.1.1.100,1.1.1.403	ko:K00059,ko:K20900	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
REGS2_k127_5808391_8	1090320.KB900605_gene2890	4.525e-14	77.0	COG4113@1|root,COG4113@2|Bacteria,1N7ET@1224|Proteobacteria,2UG7M@28211|Alphaproteobacteria,2K7XU@204457|Sphingomonadales	204457|Sphingomonadales	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
REGS2_k127_5808391_10	870187.Thini_2235	0.0005539	47.0	2DSE5@1|root,33FS0@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K21495	-	-	-	-	ko00000,ko02048	-	-	-	-
REGS2_k127_5808391_1	215803.DB30_8111	2.381e-119	398.0	COG4214@1|root,COG4214@2|Bacteria,1MXXS@1224|Proteobacteria,437XM@68525|delta/epsilon subdivisions,2X9RD@28221|Deltaproteobacteria,2YUQ7@29|Myxococcales	28221|Deltaproteobacteria	G	Branched-chain amino acid transport system / permease component	-	-	-	ko:K10544	ko02010,map02010	M00215	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.4	-	-	BPD_transp_2
REGS2_k127_5808391_3	469383.Cwoe_5339	2.035e-89	302.0	COG1129@1|root,COG1129@2|Bacteria,2GJDV@201174|Actinobacteria	201174|Actinobacteria	G	ABC transporter	xylG	-	3.6.3.17	ko:K02056,ko:K10545	ko02010,map02010	M00215,M00221	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2,3.A.1.2.4	-	-	ABC_tran
REGS2_k127_5808391_0	1242864.D187_007190	3.105e-132	434.0	COG4213@1|root,COG4213@2|Bacteria,1R4J2@1224|Proteobacteria,43B1Y@68525|delta/epsilon subdivisions,2X6G1@28221|Deltaproteobacteria,2Z3AX@29|Myxococcales	28221|Deltaproteobacteria	G	Periplasmic binding protein domain	-	-	-	ko:K10543	ko02010,map02010	M00215	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.4	-	-	Peripla_BP_4
REGS2_k127_5808391_7	479431.Namu_4034	1.263e-14	83.0	29JYD@1|root,33FMY@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS2_k127_5808391_9	78346.BRUM_0119	3.762e-10	70.0	COG0515@1|root,COG0515@2|Bacteria,2IB6I@201174|Actinobacteria,4D0BZ@85004|Bifidobacteriales	201174|Actinobacteria	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
REGS2_k127_5808391_6	357808.RoseRS_2125	1.344e-40	165.0	COG1349@1|root,COG2865@1|root,COG1349@2|Bacteria,COG2865@2|Bacteria,2G7JP@200795|Chloroflexi,374XQ@32061|Chloroflexia	32061|Chloroflexia	K	PFAM AAA-4 family protein	-	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AlbA_2,HATPase_c_4,HTH_DeoR
REGS2_k127_5862393_10	1499967.BAYZ01000137_gene111	1.748e-12	75.0	2FGP7@1|root,348IT@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS2_k127_5862393_5	1123248.KB893316_gene4667	6.388e-40	152.0	COG5646@1|root,COG5646@2|Bacteria,4NSDH@976|Bacteroidetes,1ITAW@117747|Sphingobacteriia	976|Bacteroidetes	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
REGS2_k127_5862393_7	869210.Marky_1116	2.532e-32	131.0	COG1510@1|root,COG1510@2|Bacteria,1WKHD@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	K	regulation of RNA biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
REGS2_k127_5862393_4	410358.Mlab_1692	2.553e-49	194.0	COG2020@1|root,arCOG03580@2157|Archaea,2Y4MT@28890|Euryarchaeota	28890|Euryarchaeota	O	PFAM Isoprenylcysteine carboxyl methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	ICMT
REGS2_k127_5862393_2	1125863.JAFN01000001_gene2948	4.822e-71	257.0	COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,42N87@68525|delta/epsilon subdivisions,2WK1B@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	pfam abc1	-	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1,APH,WaaY
REGS2_k127_5862393_3	316274.Haur_0974	3.342e-70	250.0	COG1028@1|root,COG1028@2|Bacteria,2G8DK@200795|Chloroflexi,3776U@32061|Chloroflexia	32061|Chloroflexia	IQ	short-chain dehydrogenase reductase SDR	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
REGS2_k127_5862393_1	309801.trd_0620	1.169e-83	288.0	COG1606@1|root,COG1606@2|Bacteria,2G6AU@200795|Chloroflexi	200795|Chloroflexi	L	tRNA processing	-	-	-	ko:K06864	-	-	-	-	ko00000	-	-	-	Asn_synthase,NAD_synthase
REGS2_k127_5862393_0	289376.THEYE_A0029	9.417e-302	941.0	COG0365@1|root,COG0365@2|Bacteria,3J0BJ@40117|Nitrospirae	40117|Nitrospirae	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
REGS2_k127_5862393_6	309807.SRU_1294	4.355e-33	134.0	COG2096@1|root,COG2096@2|Bacteria,4NFHQ@976|Bacteroidetes,1FJBE@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	Cobalamin adenosyltransferase	yvqK	-	2.5.1.17	ko:K00798	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	Cob_adeno_trans
REGS2_k127_5862393_11	1049564.TevJSym_ap00040	0.0005322	47.0	COG3462@1|root,COG3462@2|Bacteria,1NGXC@1224|Proteobacteria,1SGF3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Short C-terminal domain	-	-	-	ko:K08982	-	-	-	-	ko00000	-	-	-	SHOCT
REGS2_k127_5862393_8	641491.DND132_1977	3.289e-14	79.0	COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,42MN5@68525|delta/epsilon subdivisions,2WINN@28221|Deltaproteobacteria,2M9B2@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen	glnD	-	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	ACT,DUF294,GlnD_UR_UTase,GlnE,HD,NTP_transf_2
REGS2_k127_5929603_15	351160.RCIX562	1.191e-44	189.0	arCOG03561@1|root,arCOG03561@2157|Archaea	2157|Archaea	G	PFAM NHL repeat containing protein	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS2_k127_5929603_22	1121028.ARQE01000012_gene412	6.915e-24	121.0	COG0265@1|root,COG0265@2|Bacteria	2|Bacteria	O	serine-type endopeptidase activity	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	Beta_helix,CBM_6,DUF1565,PDZ_2,Trypsin_2
REGS2_k127_5929603_2	1232436.CAPF01000054_gene161	2.392e-159	514.0	COG0151@1|root,COG0151@2|Bacteria,2I2F5@201174|Actinobacteria,4CU8J@84998|Coriobacteriia	84998|Coriobacteriia	F	Belongs to the GARS family	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	DegV,GARS_A,GARS_C,GARS_N
REGS2_k127_5929603_1	1125863.JAFN01000001_gene2093	1.174e-182	580.0	COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,42MN3@68525|delta/epsilon subdivisions,2WMHC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
REGS2_k127_5929603_10	445975.COLSTE_02228	1.73e-67	232.0	COG0041@1|root,COG0041@2|Bacteria,2IFFD@201174|Actinobacteria,4CVVV@84998|Coriobacteriia	84998|Coriobacteriia	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
REGS2_k127_5929603_21	1206737.BAGF01000081_gene5197	2.991e-25	118.0	COG0702@1|root,COG0702@2|Bacteria,2IGGT@201174|Actinobacteria,4G935@85025|Nocardiaceae	201174|Actinobacteria	GM	RmlD substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10
REGS2_k127_5929603_4	1094980.Mpsy_0336	2.366e-127	413.0	COG0040@1|root,arCOG02208@2157|Archaea,2Y2ZH@28890|Euryarchaeota,2NA8F@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity	-	-	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG,HisG_C
REGS2_k127_5929603_24	1110697.NCAST_35_00560	4.596e-13	79.0	COG3794@1|root,COG3794@2|Bacteria,2GSBM@201174|Actinobacteria,4G2JT@85025|Nocardiaceae	201174|Actinobacteria	C	Copper binding proteins, plastocyanin/azurin family	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cupredoxin_1
REGS2_k127_5929603_5	1035308.AQYY01000001_gene1905	5.012e-101	334.0	COG1136@1|root,COG1136@2|Bacteria,1TQC9@1239|Firmicutes,248Z6@186801|Clostridia,260NV@186807|Peptococcaceae	186801|Clostridia	V	ABC-type antimicrobial peptide transport system, ATPase component	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
REGS2_k127_5929603_0	1035308.AQYY01000001_gene1906	2.774e-268	850.0	COG0577@1|root,COG4591@1|root,COG0577@2|Bacteria,COG4591@2|Bacteria,1TRE5@1239|Firmicutes,25GUR@186801|Clostridia,265C6@186807|Peptococcaceae	186801|Clostridia	MV	ABC-type transport system, involved in lipoprotein release, permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
REGS2_k127_5929603_26	1454004.AW11_03100	1.227e-10	71.0	2DC00@1|root,2ZC4V@2|Bacteria,1RBPR@1224|Proteobacteria,2W3QT@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS2_k127_5929603_3	477641.MODMU_3515	2.261e-133	437.0	COG1915@1|root,COG1915@2|Bacteria,2GMEZ@201174|Actinobacteria,4EUTP@85013|Frankiales	201174|Actinobacteria	S	PFAM LOR SDH bifunctional	-	-	-	-	-	-	-	-	-	-	-	-	Saccharop_dh_N
REGS2_k127_5929603_9	926569.ANT_24880	4.501e-68	241.0	COG1028@1|root,COG1028@2|Bacteria,2G8EM@200795|Chloroflexi	200795|Chloroflexi	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
REGS2_k127_5929603_12	555079.Toce_0259	5.343e-49	184.0	COG0122@1|root,COG0122@2|Bacteria,1V5KW@1239|Firmicutes,25BR2@186801|Clostridia	186801|Clostridia	L	endonuclease III	-	-	3.2.2.21	ko:K01247	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
REGS2_k127_5929603_16	635013.TherJR_1195	4.557e-37	159.0	COG0642@1|root,COG5000@1|root,COG2205@2|Bacteria,COG5000@2|Bacteria,1TQMV@1239|Firmicutes,247SE@186801|Clostridia,260ZK@186807|Peptococcaceae	186801|Clostridia	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	2.1.1.80,3.1.1.61	ko:K13924	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	DUF3365,HAMP,HATPase_c,HisKA,PAS_9,Response_reg
REGS2_k127_5929603_11	1123023.JIAI01000001_gene6865	4.144e-64	233.0	COG0583@1|root,COG0583@2|Bacteria,2GM99@201174|Actinobacteria,4E41C@85010|Pseudonocardiales	201174|Actinobacteria	K	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
REGS2_k127_5929603_23	255470.cbdbA1100	3.057e-13	72.0	COG0826@1|root,COG0826@2|Bacteria,2GAVB@200795|Chloroflexi,34DF3@301297|Dehalococcoidia	301297|Dehalococcoidia	O	peptidase U32	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS2_k127_5929603_8	552811.Dehly_1194	3.045e-71	270.0	COG1592@1|root,COG1592@2|Bacteria	2|Bacteria	C	Rubrerythrin	rbr	GO:0003674,GO:0005488,GO:0005506,GO:0043167,GO:0043169,GO:0046872,GO:0046914	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
REGS2_k127_5929603_6	1341151.ASZU01000003_gene2449	7.424e-93	326.0	COG0656@1|root,COG0656@2|Bacteria,1TPM1@1239|Firmicutes,4HARE@91061|Bacilli,27BA5@186824|Thermoactinomycetaceae	91061|Bacilli	S	Aldo/keto reductase family	yvgN	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
REGS2_k127_5929603_17	1133849.O3I_034115	1.811e-35	146.0	COG0697@1|root,COG0697@2|Bacteria,2GM50@201174|Actinobacteria,4FXUZ@85025|Nocardiaceae	201174|Actinobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
REGS2_k127_5929603_18	1385517.N800_06190	5.485e-35	142.0	COG1695@1|root,COG1695@2|Bacteria,1NJSY@1224|Proteobacteria,1SG6R@1236|Gammaproteobacteria,1X6UG@135614|Xanthomonadales	135614|Xanthomonadales	K	PadR family transcriptional regulator	-	-	-	ko:K10947	-	-	-	-	ko00000,ko03000	-	-	-	PadR
REGS2_k127_5929603_7	1552758.NC00_03965	2.561e-83	293.0	COG4709@1|root,COG4709@2|Bacteria,1NX5K@1224|Proteobacteria,1SPS6@1236|Gammaproteobacteria,1X34I@135614|Xanthomonadales	135614|Xanthomonadales	S	Putative sensor	-	-	-	-	-	-	-	-	-	-	-	-	Sensor
REGS2_k127_5929603_19	234267.Acid_3617	5.131e-31	132.0	COG4758@1|root,COG4758@2|Bacteria,3Y7Z2@57723|Acidobacteria	57723|Acidobacteria	S	N-terminal domain of toast_rack, DUF2154	-	-	-	-	-	-	-	-	-	-	-	-	DUF2154,Toast_rack_N
REGS2_k127_5929603_20	335543.Sfum_3405	6.26e-26	116.0	2CEMF@1|root,33GFG@2|Bacteria,1NIQ6@1224|Proteobacteria,42X94@68525|delta/epsilon subdivisions	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS2_k127_5929603_13	574087.Acear_1505	2.544e-46	181.0	COG0778@1|root,COG0778@2|Bacteria,1UZC3@1239|Firmicutes,24BKG@186801|Clostridia,3WBQ2@53433|Halanaerobiales	186801|Clostridia	C	Putative TM nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	TM1586_NiRdase
REGS2_k127_5929603_14	742738.HMPREF9460_00753	5.699e-46	178.0	COG0524@1|root,COG1522@1|root,COG0524@2|Bacteria,COG1522@2|Bacteria,1TQR4@1239|Firmicutes,24AUP@186801|Clostridia,267XW@186813|unclassified Clostridiales	186801|Clostridia	GK	Winged helix-turn-helix DNA-binding	rbsK	-	2.7.1.15,2.7.1.83	ko:K00852,ko:K16328	ko00030,ko00240,map00030,map00240	-	R01051,R02750,R03315	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	HTH_24,PfkB
REGS2_k127_6000698_6	768704.Desmer_4269	2.813e-62	227.0	COG0577@1|root,COG0577@2|Bacteria,1TPUU@1239|Firmicutes,2483J@186801|Clostridia,260DV@186807|Peptococcaceae	186801|Clostridia	V	ABC-type antimicrobial peptide transport system, permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
REGS2_k127_6000698_2	633147.Olsu_1372	1.414e-95	322.0	COG1136@1|root,COG1136@2|Bacteria,2GK3I@201174|Actinobacteria,4CV1R@84998|Coriobacteriia	84998|Coriobacteriia	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
REGS2_k127_6000698_8	86416.Clopa_0293	7.775e-30	133.0	COG0845@1|root,COG0845@2|Bacteria,1TT2M@1239|Firmicutes,24BJV@186801|Clostridia,36ECY@31979|Clostridiaceae	186801|Clostridia	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
REGS2_k127_6000698_3	452652.KSE_27780	2.988e-87	297.0	COG2197@1|root,COG2197@2|Bacteria,2GJ46@201174|Actinobacteria,2M4Z8@2063|Kitasatospora	201174|Actinobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
REGS2_k127_6000698_4	67315.JOBD01000013_gene6986	4.538e-75	269.0	COG4585@1|root,COG4585@2|Bacteria,2GKV2@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
REGS2_k127_6000698_7	748727.CLJU_c01500	2.15e-43	174.0	COG0791@1|root,COG3883@1|root,COG0791@2|Bacteria,COG3883@2|Bacteria,1UVYK@1239|Firmicutes,249G6@186801|Clostridia,36FW2@31979|Clostridiaceae	186801|Clostridia	M	NLP P60 protein	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	NLPC_P60,SH3_3
REGS2_k127_6000698_0	309799.DICTH_1914	7.109e-159	515.0	COG0312@1|root,COG0312@2|Bacteria	2|Bacteria	S	metallopeptidase activity	tldD2	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
REGS2_k127_6000698_5	1379698.RBG1_1C00001G1510	1.047e-71	261.0	COG0312@1|root,COG0312@2|Bacteria,2NP7I@2323|unclassified Bacteria	2|Bacteria	S	Putative modulator of DNA gyrase	tldE2	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
REGS2_k127_6000698_1	330214.NIDE1046	7.673e-135	477.0	COG0642@1|root,COG0784@1|root,COG2202@1|root,COG2203@1|root,COG4191@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	barA	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	CBS,GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg,dCache_1
REGS2_k127_6000698_10	56780.SYN_00227	4.392e-16	85.0	COG2198@1|root,COG2198@2|Bacteria,1NJUT@1224|Proteobacteria,42WXF@68525|delta/epsilon subdivisions,2WSRZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	(Hpt) domain	-	-	-	-	-	-	-	-	-	-	-	-	Hpt
REGS2_k127_6000698_9	1565129.JSFF01000031_gene2975	1.42e-28	123.0	COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,1RPH3@1236|Gammaproteobacteria,2Q9DZ@267890|Shewanellaceae	1236|Gammaproteobacteria	T	metal-dependent phosphohydrolase, HD sub domain	-	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	HD,Response_reg
REGS2_k127_6122245_3	1197130.BAFM01000014_gene2342	2.658e-05	55.0	COG1305@1|root,COG1404@1|root,arCOG07560@1|root,arCOG00702@2157|Archaea,arCOG02486@2157|Archaea,arCOG07560@2157|Archaea,2XTGN@28890|Euryarchaeota,23TTV@183963|Halobacteria	183963|Halobacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,CarboxypepD_reg,Peptidase_S8
REGS2_k127_6122245_0	469378.Ccur_11510	1.405e-194	615.0	COG0104@1|root,COG0104@2|Bacteria,2GMP4@201174|Actinobacteria,4CUX7@84998|Coriobacteriia	84998|Coriobacteriia	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
REGS2_k127_6122245_2	338966.Ppro_2904	3.798e-12	78.0	COG0845@1|root,COG0845@2|Bacteria,1MUG6@1224|Proteobacteria,42R8A@68525|delta/epsilon subdivisions,2WM6Z@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	PFAM secretion protein HlyD family protein	-	-	-	ko:K01993	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_D23
REGS2_k127_6122245_1	1035308.AQYY01000001_gene2166	5.705e-46	175.0	COG1566@1|root,COG1566@2|Bacteria,1VE7A@1239|Firmicutes,25H0I@186801|Clostridia	186801|Clostridia	V	Barrel-sandwich domain of CusB or HlyD membrane-fusion	-	-	-	ko:K01993	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3,OEP
REGS2_k127_6178485_0	698757.Pogu_0973	1.442e-85	292.0	COG1013@1|root,arCOG01599@2157|Archaea,2XPQG@28889|Crenarchaeota	28889|Crenarchaeota	C	TIGRFAM pyruvate ferredoxin flavodoxin oxidoreductase, beta subunit	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFO_beta_C,TPP_enzyme_C
REGS2_k127_6178485_2	929712.KI912613_gene3852	7.905e-77	284.0	COG2203@1|root,COG3437@1|root,COG2203@2|Bacteria,COG3437@2|Bacteria,2I49F@201174|Actinobacteria,4CRG8@84995|Rubrobacteria	84995|Rubrobacteria	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HD,MASE1
REGS2_k127_6178485_1	1380390.JIAT01000013_gene39	5.178e-77	280.0	COG3437@1|root,COG3437@2|Bacteria,2I49F@201174|Actinobacteria,4CRG8@84995|Rubrobacteria	84995|Rubrobacteria	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HD,MASE1
REGS2_k127_6220257_17	1232436.CAPF01000094_gene83	2.793e-05	56.0	2DKYW@1|root,30Y62@2|Bacteria,2HW6D@201174|Actinobacteria,4CY21@84998|Coriobacteriia	84998|Coriobacteriia	S	zinc-ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	zinc_ribbon_2
REGS2_k127_6220257_12	1210046.B277_05354	1.029e-17	95.0	COG2267@1|root,COG2267@2|Bacteria,2I2IM@201174|Actinobacteria,4FK2Q@85021|Intrasporangiaceae	201174|Actinobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
REGS2_k127_6220257_6	756499.Desde_3375	2.415e-38	149.0	COG4832@1|root,COG4832@2|Bacteria	2|Bacteria	S	GyrI-like small molecule binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GyrI-like
REGS2_k127_6220257_11	105425.BBPL01000030_gene4534	1.473e-20	100.0	COG0791@1|root,COG0791@2|Bacteria,2I61A@201174|Actinobacteria,2NK0Y@228398|Streptacidiphilus	201174|Actinobacteria	M	belongs to the nudix hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	VCBS
REGS2_k127_6220257_14	1121422.AUMW01000032_gene3058	3.291e-11	70.0	COG2165@1|root,COG2165@2|Bacteria,1VK8F@1239|Firmicutes,24S7I@186801|Clostridia	186801|Clostridia	NU	Prepilin-type cleavage methylation N-terminal domain protein	-	-	-	ko:K02650	ko02020,map02020	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.15.2	-	-	N_methyl
REGS2_k127_6220257_5	1307761.L21SP2_1019	2.261e-88	307.0	COG0010@1|root,COG3457@1|root,COG0010@2|Bacteria,COG3457@2|Bacteria,2JA1N@203691|Spirochaetes	203691|Spirochaetes	E	Alanine racemase, N-terminal domain	-	-	5.1.1.12	ko:K21898	ko00472,map00472	-	R00672	RC00302	ko00000,ko00001,ko01000	-	-	-	Ala_racemase_N
REGS2_k127_6220257_3	555079.Toce_1484	2.735e-109	374.0	COG0145@1|root,COG0145@2|Bacteria,1UK65@1239|Firmicutes,25FMC@186801|Clostridia,42J7X@68295|Thermoanaerobacterales	186801|Clostridia	EQ	MutL protein	-	-	-	-	-	-	-	-	-	-	-	-	MutL
REGS2_k127_6220257_1	555079.Toce_1485	0.0	1042.0	COG2185@1|root,COG2185@2|Bacteria,1UJHA@1239|Firmicutes,25F35@186801|Clostridia	186801|Clostridia	I	D-Lysine 5,6-aminomutase alpha subunit	-	-	5.4.3.5	ko:K17898	ko00472,map00472	-	R02461	RC00719	ko00000,ko00001,ko01000	-	-	-	B12-binding,Lys-AminoMut_A,OAM_dimer
REGS2_k127_6220257_8	646529.Desaci_1876	7.948e-27	113.0	2DMJP@1|root,32S0N@2|Bacteria,1V766@1239|Firmicutes,24K8E@186801|Clostridia	186801|Clostridia	S	D-ornithine 4,5-aminomutase alpha-subunit	oraS	-	5.4.3.5	ko:K17899	ko00472,map00472	-	R02461	RC00719	ko00000,ko00001,ko01000	-	-	-	OAM_alpha
REGS2_k127_6220257_2	767029.HMPREF9154_0894	4.611e-188	599.0	COG0031@1|root,COG0031@2|Bacteria,2GJGN@201174|Actinobacteria	201174|Actinobacteria	E	Pyridoxal-phosphate dependent enzyme	-	-	2.3.1.263	ko:K21400	-	-	-	-	ko00000,ko01000	-	-	-	PALP
REGS2_k127_6220257_9	373903.Hore_21110	1.036e-22	101.0	2E6IF@1|root,3315M@2|Bacteria,1VAX0@1239|Firmicutes,24N55@186801|Clostridia	186801|Clostridia	-	-	ortA	GO:0006082,GO:0006520,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0071704,GO:1901564,GO:1901605	2.3.1.263	ko:K21399	-	-	-	-	ko00000,ko01000	-	-	-	-
REGS2_k127_6220257_4	1009370.ALO_08500	5.074e-104	348.0	COG3804@1|root,COG3804@2|Bacteria,1TRNF@1239|Firmicutes,4H7KW@909932|Negativicutes	909932|Negativicutes	C	Dihydrodipicolinate reductase, N-terminus	-	-	-	-	-	-	-	-	-	-	-	-	DapB_N
REGS2_k127_6220257_7	111780.Sta7437_1943	6.985e-28	133.0	COG2931@1|root,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF1735,HemolysinCabind,Laminin_G_3
REGS2_k127_6220257_10	511051.CSE_00210	4.532e-21	111.0	COG1520@1|root,COG3292@1|root,COG1520@2|Bacteria,COG3292@2|Bacteria	2|Bacteria	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	-	ko:K02406,ko:K19693	ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134	-	-	-	ko00000,ko00001,ko02035,ko03000	-	-	-	-
REGS2_k127_6220257_0	243231.GSU1394	0.0	1119.0	COG1874@1|root,COG2132@1|root,COG1874@2|Bacteria,COG2132@2|Bacteria,1R9AF@1224|Proteobacteria,42YQG@68525|delta/epsilon subdivisions,2WTP2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	Multicopper oxidase	ompB	-	-	-	-	-	-	-	-	-	-	-	ASH,Cu-oxidase_2
REGS2_k127_6220257_15	1128421.JAGA01000003_gene3162	1.308e-06	59.0	COG3794@1|root,COG3794@2|Bacteria	2|Bacteria	C	PFAM blue (type 1) copper domain protein	-	-	1.7.2.1	ko:K00368	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000	-	-	-	Copper-bind,Cu-oxidase_3,Cupredoxin_1
REGS2_k127_6220257_13	1198449.ACAM_0767	4.315e-12	72.0	COG4113@1|root,arCOG00727@2157|Archaea,2XR7P@28889|Crenarchaeota	28889|Crenarchaeota	V	PilT protein domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PIN
REGS2_k127_6220257_16	1109445.AGSX01000131_gene2806	1.992e-05	49.0	COG2832@1|root,COG2832@2|Bacteria,1N7BI@1224|Proteobacteria,1TAUG@1236|Gammaproteobacteria,1Z2XG@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	S	protein conserved in bacteria	-	-	-	ko:K09790	-	-	-	-	ko00000	-	-	-	DUF454
REGS2_k127_6240721_0	471855.Shel_05490	2.612e-207	655.0	COG0459@1|root,COG0459@2|Bacteria,2GKC9@201174|Actinobacteria,4CV5V@84998|Coriobacteriia	84998|Coriobacteriia	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
REGS2_k127_6240721_5	1273125.Rrhod_0005	1.977e-38	147.0	COG0234@1|root,COG0234@2|Bacteria,2IKTH@201174|Actinobacteria,4G204@85025|Nocardiaceae	201174|Actinobacteria	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0019899,GO:0030312,GO:0031323,GO:0031326,GO:0033554,GO:0034605,GO:0035375,GO:0035966,GO:0040007,GO:0042221,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0046872,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065007,GO:0071944,GO:0080090,GO:1903506,GO:2000112,GO:2001141	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
REGS2_k127_6240721_1	1504822.CCNO01000014_gene1631	1.111e-144	481.0	COG0454@1|root,COG0533@1|root,COG1214@1|root,COG0456@2|Bacteria,COG0533@2|Bacteria,COG1214@2|Bacteria,2NNXP@2323|unclassified Bacteria	2|Bacteria	O	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	GO:0000287,GO:0000408,GO:0002949,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0004596,GO:0005488,GO:0005506,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006464,GO:0006473,GO:0006474,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008080,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0008999,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016787,GO:0017189,GO:0018193,GO:0018194,GO:0019538,GO:0030312,GO:0031365,GO:0032991,GO:0034212,GO:0034470,GO:0034641,GO:0034660,GO:0036211,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0051604,GO:0070011,GO:0070525,GO:0071704,GO:0071944,GO:0090304,GO:0140030,GO:0140032,GO:0140096,GO:1901360,GO:1901564	2.3.1.128,2.3.1.234	ko:K01409,ko:K03070,ko:K03789,ko:K14742	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	R10648	RC00070,RC00416	ko00000,ko00001,ko00002,ko01000,ko02044,ko03009,ko03016	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	Acetyltransf_1,Peptidase_M22
REGS2_k127_6240721_4	1232436.CAPF01000055_gene150	2.342e-41	163.0	COG0454@1|root,COG0533@1|root,COG1214@1|root,COG0456@2|Bacteria,COG0533@2|Bacteria,COG1214@2|Bacteria,2GJ98@201174|Actinobacteria,4CUKY@84998|Coriobacteriia	84998|Coriobacteriia	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Acetyltransf_1,Peptidase_M22
REGS2_k127_6240721_6	1121472.AQWN01000002_gene2204	1.982e-33	137.0	COG0802@1|root,COG0802@2|Bacteria,1V6CV@1239|Firmicutes,24MSS@186801|Clostridia,2621R@186807|Peptococcaceae	186801|Clostridia	S	PFAM Uncharacterised P-loop hydrolase UPF0079	ydiB	-	-	ko:K06925	-	-	-	-	ko00000,ko03016	-	-	-	TsaE
REGS2_k127_6240721_2	1034345.CAEM01000032_gene49	2.312e-63	240.0	COG1573@1|root,COG1573@2|Bacteria,2GMPT@201174|Actinobacteria,4CUM5@84998|Coriobacteriia	84998|Coriobacteriia	L	Uracil-DNA glycosylase, family 4	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
REGS2_k127_6240721_3	1123373.ATXI01000024_gene116	7.604e-46	172.0	COG0778@1|root,COG0778@2|Bacteria,2GHHZ@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	C	Putative TM nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
REGS2_k127_6449206_8	289376.THEYE_A0029	2.39e-13	75.0	COG0365@1|root,COG0365@2|Bacteria,3J0BJ@40117|Nitrospirae	40117|Nitrospirae	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
REGS2_k127_6449206_3	670487.Ocepr_1065	2.287e-49	188.0	COG1307@1|root,COG1307@2|Bacteria,1WIY0@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	PFAM Uncharacterised protein, DegV family COG1307	-	-	-	-	-	-	-	-	-	-	-	-	DegV
REGS2_k127_6449206_4	649764.HMPREF0762_00163	5.319e-36	140.0	COG0537@1|root,COG0537@2|Bacteria,2HG9A@201174|Actinobacteria,4CVZ1@84998|Coriobacteriia	84998|Coriobacteriia	FG	Scavenger mRNA decapping enzyme C-term binding	-	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
REGS2_k127_6449206_7	1224746.B932_2144	2.278e-14	76.0	COG1722@1|root,COG1722@2|Bacteria,1PTYQ@1224|Proteobacteria,2UFD6@28211|Alphaproteobacteria,2JU6S@204441|Rhodospirillales	204441|Rhodospirillales	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseB	-	3.1.11.6	ko:K03602	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_S
REGS2_k127_6449206_0	502558.EGYY_13110	9.913e-114	397.0	COG1570@1|root,COG1570@2|Bacteria,2GJAS@201174|Actinobacteria,4CUPF@84998|Coriobacteriia	84998|Coriobacteriia	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
REGS2_k127_6449206_2	269796.Rru_A0089	1.728e-96	331.0	COG0514@1|root,COG0514@2|Bacteria,1MVGG@1224|Proteobacteria,2TS8B@28211|Alphaproteobacteria,2JVJX@204441|Rhodospirillales	204441|Rhodospirillales	L	RQC	-	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,HRDC,Helicase_C,RQC,RecQ_Zn_bind
REGS2_k127_6449206_1	1121866.AUGK01000004_gene218	2.179e-98	334.0	COG0349@1|root,COG0349@2|Bacteria,2GKNM@201174|Actinobacteria,4CV2Q@84998|Coriobacteriia	84998|Coriobacteriia	J	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides	rnd	-	3.1.13.5	ko:K03684	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DNA_pol_A_exo1,HRDC
REGS2_k127_6449206_6	351160.RCIX2593	2.034e-16	93.0	arCOG03622@1|root,arCOG03622@2157|Archaea,2Y55W@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS2_k127_6449206_5	553184.ATORI0001_0894	2.129e-26	126.0	COG4907@1|root,COG4907@2|Bacteria,2HUJ8@201174|Actinobacteria,4CUWT@84998|Coriobacteriia	84998|Coriobacteriia	S	Predicted membrane protein (DUF2207)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2207
REGS2_k127_6529524_10	62928.azo2825	4.217e-06	51.0	COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,2VH78@28216|Betaproteobacteria,2KXQK@206389|Rhodocyclales	206389|Rhodocyclales	H	Molybdopterin biosynthesis	-	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
REGS2_k127_6529524_11	760568.Desku_2909	5.866e-06	54.0	2DSKT@1|root,33GJ4@2|Bacteria,1VKB9@1239|Firmicutes,24VAK@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS2_k127_6529524_5	485916.Dtox_3499	2.472e-36	145.0	COG1763@1|root,COG1763@2|Bacteria,1VFA0@1239|Firmicutes,24IYN@186801|Clostridia,262F6@186807|Peptococcaceae	186801|Clostridia	H	Molybdopterin-guanine dinucleotide biosynthesis	mobB	-	-	ko:K03753	-	-	-	-	ko00000	-	-	-	MobB
REGS2_k127_6529524_0	1235794.C811_00907	3.401e-120	394.0	COG2896@1|root,COG2896@2|Bacteria,2GN0V@201174|Actinobacteria,4CUGB@84998|Coriobacteriia	84998|Coriobacteriia	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM
REGS2_k127_6529524_3	452662.SJA_C1-08410	8.672e-53	190.0	COG0315@1|root,COG0315@2|Bacteria,1RCYZ@1224|Proteobacteria,2U747@28211|Alphaproteobacteria,2K4GG@204457|Sphingomonadales	204457|Sphingomonadales	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
REGS2_k127_6529524_2	479437.Elen_0255	4.706e-58	214.0	COG2258@1|root,COG2258@2|Bacteria,2GMBE@201174|Actinobacteria,4CVNR@84998|Coriobacteriia	84998|Coriobacteriia	S	MOSC domain	-	-	-	-	-	-	-	-	-	-	-	-	MOSC
REGS2_k127_6529524_4	1131462.DCF50_p1641	1.744e-47	175.0	COG0521@1|root,COG0521@2|Bacteria,1V3XM@1239|Firmicutes,24HG2@186801|Clostridia,261XV@186807|Peptococcaceae	186801|Clostridia	H	TIGRFAM molybdenum cofactor synthesis	mog	-	-	-	-	-	-	-	-	-	-	-	MOSC,MoCF_biosynth
REGS2_k127_6529524_1	1121346.KB899814_gene1831	1.563e-94	328.0	COG0520@1|root,COG0520@2|Bacteria,1TQ1W@1239|Firmicutes,4HDS3@91061|Bacilli,26SPW@186822|Paenibacillaceae	91061|Bacilli	E	Cysteine desulfurase	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
REGS2_k127_6529524_9	1131462.DCF50_p1851	8.065e-17	90.0	COG1969@1|root,COG1969@2|Bacteria,1V22Y@1239|Firmicutes,24H7X@186801|Clostridia,261Q0@186807|Peptococcaceae	186801|Clostridia	C	TIGRFAM Ni Fe-hydrogenase, b-type cytochrome subunit	-	-	-	ko:K03620	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	Ni_hydr_CYTB
REGS2_k127_6529524_7	903818.KI912269_gene259	9.803e-24	115.0	COG2864@1|root,COG2864@2|Bacteria,3Y6QW@57723|Acidobacteria	57723|Acidobacteria	C	Prokaryotic cytochrome b561	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_c3_2,Ni_hydr_CYTB
REGS2_k127_6529524_6	671143.DAMO_0825	1.043e-24	118.0	COG0484@1|root,COG2864@1|root,COG0484@2|Bacteria,COG2864@2|Bacteria,2NNNM@2323|unclassified Bacteria	2|Bacteria	C	Cytochrome b subunit of formate dehydrogenase-like protein	mccA	GO:0003674,GO:0003824,GO:0005488,GO:0005507,GO:0005515,GO:0006790,GO:0008150,GO:0008152,GO:0009058,GO:0009403,GO:0009404,GO:0009987,GO:0016002,GO:0016043,GO:0016491,GO:0016667,GO:0017144,GO:0019748,GO:0020037,GO:0022607,GO:0042802,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044237,GO:0044249,GO:0044272,GO:0044550,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0051259,GO:0051260,GO:0055114,GO:0065003,GO:0070206,GO:0070207,GO:0070813,GO:0070814,GO:0071840,GO:0097159,GO:1901363,GO:1903136	-	-	-	-	-	-	-	-	-	-	Cytochrom_c3_2,Cytochrome_C554,Ni_hydr_CYTB,Paired_CXXCH_1
REGS2_k127_6529524_8	945713.IALB_1838	4.647e-18	98.0	COG3005@1|root,COG3005@2|Bacteria	2|Bacteria	C	denitrification pathway	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_c3_2,Cytochrome_C7
REGS2_k127_6554124_14	118168.MC7420_2362	4.824e-114	375.0	COG1063@1|root,COG1063@2|Bacteria,1FZZE@1117|Cyanobacteria,1H7Y9@1150|Oscillatoriales	1117|Cyanobacteria	E	COG1063 Threonine dehydrogenase and related Zn-dependent	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N,Shikimate_DH
REGS2_k127_6554124_2	697281.Mahau_2191	6.267e-256	829.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia,42F44@68295|Thermoanaerobacterales	186801|Clostridia	V	ABC transporter, transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
REGS2_k127_6554124_3	697281.Mahau_2190	1.208e-246	781.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247T8@186801|Clostridia,42FRT@68295|Thermoanaerobacterales	186801|Clostridia	P	ABC transporter, transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
REGS2_k127_6554124_43	697281.Mahau_2189	5.01e-31	127.0	COG1846@1|root,COG1846@2|Bacteria,1VFS1@1239|Firmicutes,24QXV@186801|Clostridia,42HD1@68295|Thermoanaerobacterales	186801|Clostridia	K	Transcriptional regulator, MarR family	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
REGS2_k127_6554124_19	1120960.ATXG01000004_gene1805	5.954e-94	338.0	COG0010@1|root,COG0010@2|Bacteria,2GJA6@201174|Actinobacteria,4FKS9@85023|Microbacteriaceae	201174|Actinobacteria	E	Arginase family	-	-	3.5.3.11,3.5.3.8	ko:K01479,ko:K01480	ko00330,ko00340,ko01100,map00330,map00340,map01100	M00045,M00133	R01157,R02285	RC00024,RC00221,RC00329,RC00681	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
REGS2_k127_6554124_5	479432.Sros_6152	1.698e-215	679.0	COG2986@1|root,COG2986@2|Bacteria,2GJZW@201174|Actinobacteria,4EFM8@85012|Streptosporangiales	201174|Actinobacteria	E	Aromatic amino acid lyase	hutH	-	4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
REGS2_k127_6554124_1	710696.Intca_3339	3.481e-287	914.0	COG2987@1|root,COG2987@2|Bacteria,2GP10@201174|Actinobacteria,4FERC@85021|Intrasporangiaceae	201174|Actinobacteria	E	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate	hutU	-	4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000	-	-	-	Urocanase,Urocanase_C,Urocanase_N
REGS2_k127_6554124_6	644283.Micau_1163	3.807e-165	527.0	COG1228@1|root,COG1228@2|Bacteria,2GJH4@201174|Actinobacteria,4DBJ2@85008|Micromonosporales	201174|Actinobacteria	Q	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	hutI	-	3.5.2.7	ko:K01468	ko00340,ko01100,map00340,map01100	M00045	R02288	RC00683	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
REGS2_k127_6554124_35	646529.Desaci_0378	7.431e-52	188.0	COG2050@1|root,COG2050@2|Bacteria,1V824@1239|Firmicutes,24HWD@186801|Clostridia,2670X@186807|Peptococcaceae	186801|Clostridia	Q	PFAM thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
REGS2_k127_6554124_27	196490.AUEZ01000055_gene235	7.691e-76	259.0	2AUXR@1|root,2ZBPW@2|Bacteria,1RAID@1224|Proteobacteria,2U6KV@28211|Alphaproteobacteria,3JYM4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS2_k127_6554124_53	1122222.AXWR01000006_gene2808	3.053e-17	91.0	COG0664@1|root,COG0664@2|Bacteria,1WJXH@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	K	COGs COG0664 cAMP-binding protein - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinase	-	GO:0000166,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005515,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0017076,GO:0019219,GO:0019222,GO:0030551,GO:0030552,GO:0030554,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032553,GO:0032555,GO:0032559,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0046983,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
REGS2_k127_6554124_47	1232410.KI421421_gene3603	3.887e-28	118.0	COG0491@1|root,COG1977@1|root,COG0491@2|Bacteria,COG1977@2|Bacteria,1MXKX@1224|Proteobacteria,42R8E@68525|delta/epsilon subdivisions,2WN6V@28221|Deltaproteobacteria,43TY5@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
REGS2_k127_6554124_25	338966.Ppro_0131	1.967e-80	275.0	COG3752@1|root,COG3752@2|Bacteria,1MXCP@1224|Proteobacteria,42R9G@68525|delta/epsilon subdivisions,2WMTN@28221|Deltaproteobacteria,43TRU@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Isoprenylcysteine carboxyl methyltransferase (ICMT) family	-	-	-	-	-	-	-	-	-	-	-	-	DUF1295
REGS2_k127_6554124_0	479437.Elen_0013	3.737e-290	902.0	COG1217@1|root,COG1217@2|Bacteria,2GJUJ@201174|Actinobacteria,4CUBE@84998|Coriobacteriia	84998|Coriobacteriia	T	GTP-binding protein TypA	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
REGS2_k127_6554124_55	1234364.AMSF01000040_gene71	8.454e-06	53.0	COG1942@1|root,COG1942@2|Bacteria,1RKUX@1224|Proteobacteria,1S5EX@1236|Gammaproteobacteria,1XC4P@135614|Xanthomonadales	135614|Xanthomonadales	S	Tautomerase enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Tautomerase_2
REGS2_k127_6554124_20	215803.DB30_6887	1.816e-89	301.0	COG0789@1|root,COG0789@2|Bacteria,1REB7@1224|Proteobacteria,4347C@68525|delta/epsilon subdivisions,2X9UQ@28221|Deltaproteobacteria,2YWCK@29|Myxococcales	28221|Deltaproteobacteria	K	TipAS antibiotic-recognition domain	-	-	-	ko:K21744	-	-	-	-	ko00000,ko03000	-	-	-	MerR_1,TipAS
REGS2_k127_6554124_40	635013.TherJR_0120	4.614e-37	154.0	COG0484@1|root,COG0484@2|Bacteria	2|Bacteria	O	heat shock protein binding	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_c3_2,Cytochrome_C554,Cytochrome_C7,Paired_CXXCH_1
REGS2_k127_6554124_10	1235794.C811_02312	3.153e-139	465.0	COG2812@1|root,COG2812@2|Bacteria,2GJKA@201174|Actinobacteria,4CUJ5@84998|Coriobacteriia	84998|Coriobacteriia	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
REGS2_k127_6554124_45	469383.Cwoe_5292	6.884e-29	119.0	COG0718@1|root,COG0718@2|Bacteria,2IRC4@201174|Actinobacteria,4CQFN@84995|Rubrobacteria	84995|Rubrobacteria	L	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection	-	-	-	ko:K09747	-	-	-	-	ko00000	-	-	-	YbaB_DNA_bd
REGS2_k127_6554124_22	1203602.HMPREF1527_00947	9.745e-85	290.0	COG0353@1|root,COG0353@2|Bacteria,2GJY0@201174|Actinobacteria,4CUFU@84998|Coriobacteriia	84998|Coriobacteriia	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	-	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecR,Toprim_4
REGS2_k127_6554124_30	309799.DICTH_1983	2.778e-57	207.0	COG1014@1|root,COG1014@2|Bacteria	2|Bacteria	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	porC	-	1.2.7.1	ko:K00172	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
REGS2_k127_6554124_44	555088.DealDRAFT_1246	1.702e-30	133.0	COG1144@1|root,COG1144@2|Bacteria,1VAAJ@1239|Firmicutes,24NFD@186801|Clostridia,42KVY@68298|Syntrophomonadaceae	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	1.2.7.1	ko:K00171	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4
REGS2_k127_6554124_12	555088.DealDRAFT_1245	4.405e-135	448.0	COG0674@1|root,COG0674@2|Bacteria,1VS48@1239|Firmicutes,25E5U@186801|Clostridia,42KHC@68298|Syntrophomonadaceae	186801|Clostridia	C	Pyruvate:ferredoxin oxidoreductase core domain II	porA	-	1.2.7.1	ko:K00169	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
REGS2_k127_6554124_13	574087.Acear_0037	6.635e-127	414.0	COG1013@1|root,COG1013@2|Bacteria,1TPF0@1239|Firmicutes,24BE5@186801|Clostridia,3WAIQ@53433|Halanaerobiales	186801|Clostridia	C	PFAM Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	porB	-	1.2.7.1	ko:K00170	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
REGS2_k127_6554124_37	211165.AJLN01000112_gene44	1.674e-49	191.0	COG0226@1|root,COG0226@2|Bacteria,1G5ZG@1117|Cyanobacteria,1JMTW@1189|Stigonemataceae	1117|Cyanobacteria	P	PBP superfamily domain	-	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
REGS2_k127_6554124_29	1121918.ARWE01000001_gene1083	3.896e-67	258.0	COG2203@1|root,COG2206@1|root,COG3850@1|root,COG2203@2|Bacteria,COG2206@2|Bacteria,COG3850@2|Bacteria,1RAQS@1224|Proteobacteria,42MEJ@68525|delta/epsilon subdivisions,2X71A@28221|Deltaproteobacteria,43U3T@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,GAF_3,HAMP,HD,HD_5
REGS2_k127_6554124_7	469378.Ccur_04060	2.621e-156	503.0	COG0527@1|root,COG0527@2|Bacteria,2GN0G@201174|Actinobacteria,4CUV3@84998|Coriobacteriia	84998|Coriobacteriia	E	Belongs to the aspartokinase family	-	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT
REGS2_k127_6554124_11	1384484.AEQU_1517	1.173e-138	448.0	COG0136@1|root,COG0136@2|Bacteria,2GJJ8@201174|Actinobacteria,4CUE4@84998|Coriobacteriia	84998|Coriobacteriia	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
REGS2_k127_6554124_34	643473.KB235930_gene1921	6.962e-52	191.0	COG0745@1|root,COG0745@2|Bacteria,1FZXT@1117|Cyanobacteria,1HIFH@1161|Nostocales	1117|Cyanobacteria	T	PFAM response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
REGS2_k127_6554124_31	42256.RradSPS_0249	1.935e-56	215.0	COG5002@1|root,COG5002@2|Bacteria,2I2DU@201174|Actinobacteria,4CU3Z@84995|Rubrobacteria	84995|Rubrobacteria	T	Signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
REGS2_k127_6554124_32	429009.Adeg_1201	4.64e-55	217.0	COG2203@1|root,COG2206@1|root,COG4936@1|root,COG2203@2|Bacteria,COG2206@2|Bacteria,COG4936@2|Bacteria,1UZN2@1239|Firmicutes,248SE@186801|Clostridia,42GDE@68295|Thermoanaerobacterales	186801|Clostridia	T	PFAM Metal-dependent phosphohydrolase, HD	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HAMP,HD,PAS_9,PocR
REGS2_k127_6554124_33	1232436.CAPF01000053_gene123	4.525e-52	192.0	COG4708@1|root,COG4708@2|Bacteria,2HUQ3@201174|Actinobacteria,4CVD2@84998|Coriobacteriia	84998|Coriobacteriia	S	QueT transporter	-	-	-	-	-	-	-	-	-	-	-	-	QueT
REGS2_k127_6554124_28	697303.Thewi_1974	1.253e-67	252.0	COG1145@1|root,COG3290@1|root,COG4624@1|root,COG1145@2|Bacteria,COG3290@2|Bacteria,COG4624@2|Bacteria,1TRB4@1239|Firmicutes,25IYK@186801|Clostridia,42F3K@68295|Thermoanaerobacterales	186801|Clostridia	CT	4Fe-4S ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	FeS,Fe_hyd_lg_C,Fer4,PAS
REGS2_k127_6554124_42	941449.dsx2_0902	3.697e-31	141.0	COG2199@1|root,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,42PVX@68525|delta/epsilon subdivisions,2WIJ8@28221|Deltaproteobacteria,2M82Q@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	TIGRFAM Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GGDEF
REGS2_k127_6554124_16	552811.Dehly_0348	3.862e-106	357.0	COG1180@1|root,COG1180@2|Bacteria,2G6B2@200795|Chloroflexi,34D83@301297|Dehalococcoidia	301297|Dehalococcoidia	C	Radical SAM superfamily	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
REGS2_k127_6554124_15	479437.Elen_3046	9.1e-112	374.0	COG1216@1|root,COG1216@2|Bacteria,2HUI9@201174|Actinobacteria,4CUTI@84998|Coriobacteriia	84998|Coriobacteriia	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3
REGS2_k127_6554124_46	1384484.AEQU_1998	1.03e-28	126.0	COG0730@1|root,COG0730@2|Bacteria,2HGFS@201174|Actinobacteria,4CUMD@84998|Coriobacteriia	84998|Coriobacteriia	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
REGS2_k127_6554124_54	485913.Krac_6707	4.727e-14	85.0	COG0454@1|root,COG0456@2|Bacteria,2G7CX@200795|Chloroflexi	200795|Chloroflexi	K	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
REGS2_k127_6554124_17	742818.HMPREF9451_01697	1.694e-104	354.0	COG3275@1|root,COG3275@2|Bacteria,2GJD4@201174|Actinobacteria,4CUX5@84998|Coriobacteriia	84998|Coriobacteriia	T	histidine kinase DNA gyrase B	-	-	2.7.13.3	ko:K07704	ko02020,map02020	M00492	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	GAF_3,HATPase_c,His_kinase
REGS2_k127_6554124_24	742818.HMPREF9451_01698	1.025e-81	280.0	COG3279@1|root,COG3279@2|Bacteria,2IPFZ@201174|Actinobacteria,4CYIJ@84998|Coriobacteriia	84998|Coriobacteriia	K	response regulator receiver	-	-	-	ko:K07705	ko02020,map02020	M00492	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	LytTR,Response_reg
REGS2_k127_6554124_49	240015.ACP_0636	1.023e-22	111.0	COG0622@1|root,COG0622@2|Bacteria,3Y51P@57723|Acidobacteria,2JJEG@204432|Acidobacteriia	204432|Acidobacteriia	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	ko:K07095	-	-	-	-	ko00000	-	-	-	Metallophos_2
REGS2_k127_6554124_39	1121920.AUAU01000030_gene2713	1.445e-44	167.0	2E6X5@1|root,331GM@2|Bacteria,3Y5N8@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS2_k127_6554124_23	1304880.JAGB01000003_gene991	2.39e-84	297.0	COG0042@1|root,COG0042@2|Bacteria,1TQ2R@1239|Firmicutes,248HD@186801|Clostridia	186801|Clostridia	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	dus	-	-	ko:K05540	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
REGS2_k127_6554124_18	330214.NIDE0356	5.016e-102	352.0	COG0166@1|root,COG0166@2|Bacteria	2|Bacteria	G	Belongs to the GPI family	tal	-	2.2.1.2,5.3.1.9	ko:K01810,ko:K13810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00004,M00007,M00114	R01827,R02739,R02740,R03321	RC00376,RC00439,RC00563,RC00604	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI,TAL_FSA
REGS2_k127_6554124_52	196162.Noca_2593	3.27e-18	99.0	COG0697@1|root,COG0697@2|Bacteria,2GMPJ@201174|Actinobacteria,4DQV4@85009|Propionibacteriales	201174|Actinobacteria	EG	EamA-like transporter family	-	-	-	ko:K03298	-	-	-	-	ko00000,ko02000	2.A.7.3	-	-	EamA
REGS2_k127_6554124_9	649764.HMPREF0762_01120	3.116e-140	452.0	COG0309@1|root,COG0309@2|Bacteria,2GJ7N@201174|Actinobacteria,4CUNH@84998|Coriobacteriia	84998|Coriobacteriia	O	hydrogenase expression formation protein HypE	hypE	-	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
REGS2_k127_6554124_8	479437.Elen_0142	5.895e-141	460.0	COG0409@1|root,COG0409@2|Bacteria,2GMHA@201174|Actinobacteria,4CUKQ@84998|Coriobacteriia	84998|Coriobacteriia	O	hydrogenase expression formation protein HypD	hypD	-	-	ko:K04654	-	-	-	-	ko00000	-	-	-	HypD
REGS2_k127_6554124_51	742818.HMPREF9451_01708	7.97e-19	90.0	COG0298@1|root,COG0298@2|Bacteria,2HVAI@201174|Actinobacteria,4CWJR@84998|Coriobacteriia	84998|Coriobacteriia	O	hydrogenase assembly chaperone HypC HupF	-	-	-	ko:K04653	-	-	-	-	ko00000	-	-	-	HupF_HypC
REGS2_k127_6554124_4	2002.JOEQ01000021_gene6785	2.207e-229	737.0	COG0068@1|root,COG0068@2|Bacteria,2GJYF@201174|Actinobacteria,4EMM0@85012|Streptosporangiales	201174|Actinobacteria	O	HypF finger	-	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
REGS2_k127_6554124_26	710696.Intca_0186	1.302e-77	279.0	COG1122@1|root,COG1122@2|Bacteria,2GJ0M@201174|Actinobacteria,4FFQG@85021|Intrasporangiaceae	201174|Actinobacteria	P	Part of an ABC transporter complex. Responsible for energy coupling to the transport system	cbiO	-	-	ko:K02006,ko:K02008	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	ABC_tran
REGS2_k127_6554124_48	1463936.JOJI01000033_gene2438	1.812e-27	129.0	COG0619@1|root,COG0619@2|Bacteria,2GKQ7@201174|Actinobacteria	201174|Actinobacteria	P	Cobalt ABC transporter	cbiQ	-	-	ko:K02008	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiQ
REGS2_k127_6554124_36	357808.RoseRS_0174	1.325e-51	204.0	COG0310@1|root,COG0310@2|Bacteria,2G6ZN@200795|Chloroflexi,376DK@32061|Chloroflexia	32061|Chloroflexia	P	PFAM cobalamin (vitamin B12) biosynthesis CbiM protein	-	-	-	ko:K02007	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiM,PDGLE
REGS2_k127_6554124_38	1232410.KI421428_gene1010	5.759e-48	179.0	COG0864@1|root,COG0864@2|Bacteria,1RK4R@1224|Proteobacteria,42SID@68525|delta/epsilon subdivisions,2WQ86@28221|Deltaproteobacteria,43SGS@69541|Desulfuromonadales	28221|Deltaproteobacteria	K	nickel-responsive regulator	nikR	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141	-	ko:K07722	-	-	-	-	ko00000,ko03000	-	-	-	NikR_C,RHH_1
REGS2_k127_6554124_41	555079.Toce_0060	4.657e-37	143.0	COG3118@1|root,COG3118@2|Bacteria,1VA3Y@1239|Firmicutes,24MM5@186801|Clostridia,42GS3@68295|Thermoanaerobacterales	186801|Clostridia	O	Belongs to the thioredoxin family	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
REGS2_k127_6554124_21	1158318.ATXC01000002_gene1675	2.056e-86	297.0	COG0492@1|root,COG0492@2|Bacteria,2G4H4@200783|Aquificae	200783|Aquificae	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
REGS2_k127_6554124_56	498761.HM1_0985	4.272e-05	55.0	COG3063@1|root,COG3063@2|Bacteria,1UKRE@1239|Firmicutes,25G1S@186801|Clostridia	186801|Clostridia	NU	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS2_k127_6554124_50	1150474.JQJI01000007_gene186	1.373e-19	102.0	COG1875@1|root,COG1875@2|Bacteria,2GCGW@200918|Thermotogae	200918|Thermotogae	T	SMART Nucleotide binding protein, PINc	-	-	-	ko:K07175	-	-	-	-	ko00000	-	-	-	PIN_4,PhoH
REGS2_k127_6567059_4	521095.Apar_1338	6.055e-50	178.0	COG0172@1|root,COG0172@2|Bacteria,2GIWP@201174|Actinobacteria,4CUID@84998|Coriobacteriia	84998|Coriobacteriia	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
REGS2_k127_6567059_0	913865.DOT_5908	4.056e-121	414.0	COG0277@1|root,COG2132@1|root,COG0277@2|Bacteria,COG2132@2|Bacteria,1TQSU@1239|Firmicutes,24CJP@186801|Clostridia,260KE@186807|Peptococcaceae	186801|Clostridia	Q	Multicopper oxidase	-	-	1.16.3.3	ko:K06324	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3
REGS2_k127_6567059_3	1089553.Tph_c19090	9.194e-63	225.0	COG2159@1|root,COG2159@2|Bacteria,1TRU0@1239|Firmicutes,248VZ@186801|Clostridia,42GGM@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM amidohydrolase 2	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
REGS2_k127_6567059_1	357808.RoseRS_2562	1.566e-93	337.0	COG0364@1|root,COG0364@2|Bacteria,2G5MB@200795|Chloroflexi,374UD@32061|Chloroflexia	32061|Chloroflexia	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	zwf	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
REGS2_k127_6567059_2	1123277.KB893184_gene4169	1.01e-76	286.0	COG1023@1|root,COG1023@2|Bacteria,4PM5B@976|Bacteroidetes,47YBF@768503|Cytophagia	976|Bacteroidetes	G	6-phosphogluconate dehydrogenase, C-terminal domain	-	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
REGS2_k127_6567059_6	298655.KI912266_gene2271	1.756e-38	154.0	COG3509@1|root,COG3509@2|Bacteria,2GNV6@201174|Actinobacteria,4EU0N@85013|Frankiales	201174|Actinobacteria	Q	Esterase PHB depolymerase	-	-	-	ko:K03932	-	-	-	-	ko00000	-	CE1	-	Esterase_phd
REGS2_k127_6567059_5	573413.Spirs_2899	3.637e-47	190.0	COG3391@1|root,COG3391@2|Bacteria,2J5ZD@203691|Spirochaetes	203691|Spirochaetes	S	40-residue YVTN family beta-propeller	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
REGS2_k127_6567059_7	5016.M2UV43	6.424e-05	50.0	COG1028@1|root,KOG0725@2759|Eukaryota,39J7V@33154|Opisthokonta,3P52M@4751|Fungi,3QW1H@4890|Ascomycota,205CV@147541|Dothideomycetes,4KFD6@92860|Pleosporales	4751|Fungi	Q	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short,adh_short_C2
REGS2_k127_6682515_0	1209989.TepiRe1_1777	0.0	1246.0	COG0178@1|root,COG0178@2|Bacteria,1TPIJ@1239|Firmicutes,2485F@186801|Clostridia,42EYE@68295|Thermoanaerobacterales	186801|Clostridia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
REGS2_k127_6682515_2	935866.JAER01000035_gene3227	7.291e-05	53.0	2BMJ0@1|root,32G3X@2|Bacteria,2I09M@201174|Actinobacteria,4DWDV@85009|Propionibacteriales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS2_k127_6682515_1	300852.55771438	1.356e-105	349.0	COG0004@1|root,COG0004@2|Bacteria,1WIFS@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	Ammonium Transporter	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
REGS2_k127_6718731_12	1043205.AFYF01000075_gene2085	1.072e-53	198.0	COG0159@1|root,COG0159@2|Bacteria,2GN6T@201174|Actinobacteria,4FEEI@85021|Intrasporangiaceae	201174|Actinobacteria	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
REGS2_k127_6718731_1	1089553.Tph_c26500	1.435e-164	526.0	COG0133@1|root,COG0133@2|Bacteria,1TPI3@1239|Firmicutes,24881@186801|Clostridia,42EWK@68295|Thermoanaerobacterales	186801|Clostridia	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
REGS2_k127_6718731_14	1121468.AUBR01000014_gene2227	3.82e-41	160.0	COG0135@1|root,COG0135@2|Bacteria,1V6Y0@1239|Firmicutes,24HBQ@186801|Clostridia,42GMF@68295|Thermoanaerobacterales	186801|Clostridia	E	Belongs to the TrpF family	trpF	-	5.3.1.24	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03509	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	PRAI
REGS2_k127_6718731_0	1121422.AUMW01000001_gene2483	1.672e-167	543.0	COG1350@1|root,COG1350@2|Bacteria,1UI01@1239|Firmicutes,25E8Q@186801|Clostridia,260DP@186807|Peptococcaceae	186801|Clostridia	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
REGS2_k127_6718731_13	875328.JDM601_2133	6.252e-51	192.0	COG0134@1|root,COG0134@2|Bacteria,2GIVV@201174|Actinobacteria,232KE@1762|Mycobacteriaceae	201174|Actinobacteria	E	Belongs to the TrpC family	trpC	GO:0000162,GO:0000287,GO:0003674,GO:0003824,GO:0004425,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030312,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043167,GO:0043169,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046219,GO:0046391,GO:0046394,GO:0046483,GO:0046872,GO:0071704,GO:0071944,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.1.1.48	ko:K01609	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508	RC00944	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS
REGS2_k127_6718731_6	1121468.AUBR01000014_gene2225	7.255e-99	355.0	COG0547@1|root,COG0547@2|Bacteria,1TP8U@1239|Firmicutes,247WY@186801|Clostridia,42EK5@68295|Thermoanaerobacterales	186801|Clostridia	F	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	-	2.4.2.18,4.1.3.27	ko:K00766,ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R00985,R00986,R01073	RC00010,RC00440,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
REGS2_k127_6718731_21	1131451.O1K_02831	3.52e-05	53.0	2CCEV@1|root,2Z7ZC@2|Bacteria,1PQAK@1224|Proteobacteria,1SKFK@1236|Gammaproteobacteria,1X59B@135614|Xanthomonadales	135614|Xanthomonadales	S	Alginate export	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_exp
REGS2_k127_6718731_2	269799.Gmet_2497	7.451e-141	466.0	COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,42MXN@68525|delta/epsilon subdivisions,2WJN0@28221|Deltaproteobacteria,43TZF@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657,ko:K13503	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
REGS2_k127_6718731_16	760568.Desku_3224	8.412e-34	139.0	COG5658@1|root,COG5658@2|Bacteria,1VBIT@1239|Firmicutes,24HIG@186801|Clostridia,26217@186807|Peptococcaceae	186801|Clostridia	S	SdpI/YhfL protein family	sdpI	-	-	-	-	-	-	-	-	-	-	-	DUF1648,SdpI
REGS2_k127_6718731_19	999415.HMPREF9943_01013	3.278e-24	104.0	COG0640@1|root,COG0640@2|Bacteria,1VA3M@1239|Firmicutes,3VRPU@526524|Erysipelotrichia	526524|Erysipelotrichia	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5
REGS2_k127_6718731_17	1304874.JAFY01000005_gene1320	1.59e-31	132.0	COG3467@1|root,COG3467@2|Bacteria,3TBB5@508458|Synergistetes	508458|Synergistetes	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Pyridox_ox_2
REGS2_k127_6718731_20	1121374.KB891588_gene3345	1.185e-05	57.0	COG0501@1|root,COG0501@2|Bacteria,1MVU4@1224|Proteobacteria,1RPJ5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Zn-dependent protease with chaperone function	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
REGS2_k127_6718731_18	1111069.TCCBUS3UF1_16580	2.85e-24	105.0	COG0139@1|root,COG0140@1|root,COG0139@2|Bacteria,COG0140@2|Bacteria,1WIBP@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	Histidine biosynthesis bifunctional protein hisIE	hisI	-	3.5.4.19,3.6.1.31	ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035,R04037	RC00002,RC01055	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-CH,PRA-PH
REGS2_k127_6718731_15	289376.THEYE_A0786	7.284e-40	154.0	COG0139@1|root,COG0139@2|Bacteria,3J0T7@40117|Nitrospirae	40117|Nitrospirae	E	Phosphoribosyl-AMP cyclohydrolase	hisI	-	3.5.4.19,3.6.1.31	ko:K01496,ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035,R04037	RC00002,RC01055	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-CH,PRA-PH
REGS2_k127_6718731_5	1125712.HMPREF1316_1600	4.106e-104	355.0	COG0107@1|root,COG0107@2|Bacteria,2GIRP@201174|Actinobacteria,4CUUE@84998|Coriobacteriia	84998|Coriobacteriia	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	-	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
REGS2_k127_6718731_10	1121472.AQWN01000002_gene2275	1.055e-71	249.0	COG0106@1|root,COG0106@2|Bacteria,1V1IR@1239|Firmicutes,24GBJ@186801|Clostridia,260RZ@186807|Peptococcaceae	186801|Clostridia	E	TIGRFAM Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase	hisA	-	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
REGS2_k127_6718731_11	767817.Desgi_2464	3.883e-67	239.0	COG0118@1|root,COG0118@2|Bacteria,1TQT0@1239|Firmicutes,248SH@186801|Clostridia,260M0@186807|Peptococcaceae	186801|Clostridia	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	-	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
REGS2_k127_6718731_7	479437.Elen_1081	5.597e-78	266.0	COG0131@1|root,COG0131@2|Bacteria,2GKMD@201174|Actinobacteria,4CUNW@84998|Coriobacteriia	84998|Coriobacteriia	E	Imidazoleglycerol-phosphate dehydratase	hisB	-	4.2.1.19	ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03457	RC00932	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPD
REGS2_k127_6718731_4	1034345.CAEM01000014_gene137	2.008e-130	427.0	COG0079@1|root,COG0079@2|Bacteria,2GJ9W@201174|Actinobacteria,4CV62@84998|Coriobacteriia	84998|Coriobacteriia	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
REGS2_k127_6718731_3	502558.EGYY_20080	1.269e-139	463.0	COG0141@1|root,COG0141@2|Bacteria,2GKKA@201174|Actinobacteria,4CURH@84998|Coriobacteriia	84998|Coriobacteriia	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	-	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
REGS2_k127_6718731_8	1235794.C811_00857	2.181e-73	256.0	COG0040@1|root,COG3705@1|root,COG0040@2|Bacteria,COG3705@2|Bacteria,2GNAX@201174|Actinobacteria,4CUNG@84998|Coriobacteriia	84998|Coriobacteriia	E	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity	hisG	-	2.4.2.17	ko:K00765,ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG,tRNA-synt_His
REGS2_k127_6718731_9	479437.Elen_1078	8.845e-73	258.0	COG0040@1|root,COG3705@1|root,COG0040@2|Bacteria,COG3705@2|Bacteria,2GNAX@201174|Actinobacteria,4CUNG@84998|Coriobacteriia	84998|Coriobacteriia	E	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity	hisG	-	2.4.2.17	ko:K00765,ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG,tRNA-synt_His
REGS2_k127_6751501_5	401526.TcarDRAFT_2678	1.352e-47	181.0	COG1227@1|root,COG4109@1|root,COG1227@2|Bacteria,COG4109@2|Bacteria,1TPH6@1239|Firmicutes,4H2CN@909932|Negativicutes	909932|Negativicutes	C	DHHA2 domain protein	ppaC	-	3.6.1.1	ko:K15986	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	CBS,DHH,DHHA2,DRTGG
REGS2_k127_6751501_0	471855.Shel_16340	4.351e-237	756.0	COG0210@1|root,COG0210@2|Bacteria,2GISS@201174|Actinobacteria,4CUMT@84998|Coriobacteriia	84998|Coriobacteriia	L	DNA helicase	-	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
REGS2_k127_6751501_9	398767.Glov_0916	3.927e-21	96.0	COG3369@1|root,COG3369@2|Bacteria,1N6QZ@1224|Proteobacteria	1224|Proteobacteria	S	Zinc finger cdgsh-type domain protein	-	-	-	-	-	-	-	-	-	-	-	-	zf-CDGSH
REGS2_k127_6751501_4	1034345.CAEM01000017_gene1600	1.129e-93	316.0	COG2876@1|root,COG2876@2|Bacteria,2I3UA@201174|Actinobacteria,4CV4Q@84998|Coriobacteriia	84998|Coriobacteriia	E	DAHP synthetase I family	aroF	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
REGS2_k127_6751501_8	502558.EGYY_24650	1.502e-21	99.0	COG1605@1|root,COG1605@2|Bacteria,2HDDB@201174|Actinobacteria,4CW2X@84998|Coriobacteriia	84998|Coriobacteriia	E	Chorismate mutase type II	-	-	-	-	-	-	-	-	-	-	-	-	CM_2
REGS2_k127_6751501_1	1504822.CCNO01000014_gene1620	1.084e-204	668.0	COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,2NNRS@2323|unclassified Bacteria	2|Bacteria	F	Catalyzes the synthesis of GMP from XMP	guaA	GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042278,GO:0042451,GO:0042455,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	iJN746.PP_1032,iLJ478.TM1820,iSF_1195.SF2553,iSFxv_1172.SFxv_2808,iS_1188.S2725,iYL1228.KPN_02833	GATase,GMP_synt_C,NAD_synthase
REGS2_k127_6751501_2	525909.Afer_0459	7.014e-174	554.0	COG0516@1|root,COG0516@2|Bacteria,2GKVS@201174|Actinobacteria,4CNDM@84992|Acidimicrobiia	84992|Acidimicrobiia	F	IMP dehydrogenase / GMP reductase domain	-	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
REGS2_k127_6751501_3	553184.ATORI0001_1051	9.775e-146	473.0	COG0012@1|root,COG0012@2|Bacteria,2GIXI@201174|Actinobacteria,4CUCP@84998|Coriobacteriia	84998|Coriobacteriia	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
REGS2_k127_6751501_6	319795.Dgeo_2160	1.809e-44	176.0	COG0438@1|root,COG0438@2|Bacteria,1WI1R@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
REGS2_k127_6751501_7	479437.Elen_2820	1.146e-39	150.0	COG0459@1|root,COG0459@2|Bacteria,2GKC9@201174|Actinobacteria,4CV5V@84998|Coriobacteriia	84998|Coriobacteriia	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
REGS2_k127_6794266_7	518766.Rmar_2491	1.863e-14	74.0	COG5573@1|root,COG5573@2|Bacteria	2|Bacteria	K	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
REGS2_k127_6794266_0	502558.EGYY_19770	3.265e-138	449.0	COG1186@1|root,COG1186@2|Bacteria,2GJ0F@201174|Actinobacteria,4CUA5@84998|Coriobacteriia	84998|Coriobacteriia	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
REGS2_k127_6794266_5	555079.Toce_0847	2.235e-56	207.0	COG1387@1|root,COG1387@2|Bacteria,1TQ33@1239|Firmicutes,249TZ@186801|Clostridia,42F5D@68295|Thermoanaerobacterales	186801|Clostridia	E	SMART phosphoesterase PHP domain protein	-	-	-	ko:K04477	-	-	-	-	ko00000	-	-	-	PHP
REGS2_k127_6794266_4	1121422.AUMW01000019_gene1808	1.439e-77	269.0	COG1284@1|root,COG1284@2|Bacteria,1TR9J@1239|Firmicutes,25CBM@186801|Clostridia,260G1@186807|Peptococcaceae	186801|Clostridia	S	protein conserved in bacteria (DUF2179)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2179,YitT_membrane
REGS2_k127_6794266_3	545276.KB898725_gene570	5.436e-84	314.0	COG0642@1|root,COG0745@1|root,COG2202@1|root,COG4191@1|root,COG5002@1|root,COG0642@2|Bacteria,COG0745@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,COG4191@2|Bacteria,COG5002@2|Bacteria,1RCM9@1224|Proteobacteria,1T1YU@1236|Gammaproteobacteria,1WXQM@135613|Chromatiales	135613|Chromatiales	T	Histidine Phosphotransfer domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Hpt,PAS_3,PAS_9,Response_reg
REGS2_k127_6794266_2	760568.Desku_3321	1.671e-102	349.0	COG3959@1|root,COG3959@2|Bacteria,1TT51@1239|Firmicutes,247IK@186801|Clostridia,2607I@186807|Peptococcaceae	186801|Clostridia	G	PFAM Transketolase, thiamine diphosphate binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
REGS2_k127_6794266_1	649764.HMPREF0762_00514	5.208e-115	382.0	COG3958@1|root,COG3958@2|Bacteria,2I8VM@201174|Actinobacteria,4CUD8@84998|Coriobacteriia	84998|Coriobacteriia	G	Transketolase, pyridine binding domain protein	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
REGS2_k127_6794266_6	1384484.AEQU_1282	3.124e-37	141.0	COG2884@1|root,COG2884@2|Bacteria,2GJE1@201174|Actinobacteria,4CUBJ@84998|Coriobacteriia	84998|Coriobacteriia	D	cell division ATP-binding protein FtsE	ftsE	-	-	ko:K09812	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	ABC_tran
REGS2_k127_6915368_5	1304865.JAGF01000001_gene3408	0.0002229	48.0	COG1172@1|root,COG1172@2|Bacteria,2GJDW@201174|Actinobacteria,4F2RB@85016|Cellulomonadaceae	201174|Actinobacteria	G	Branched-chain amino acid transport system / permease component	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
REGS2_k127_6915368_0	1304865.JAGF01000001_gene3407	2.813e-205	650.0	COG1129@1|root,COG1129@2|Bacteria,2GJ3F@201174|Actinobacteria,4F0N2@85016|Cellulomonadaceae	201174|Actinobacteria	G	ATPases associated with a variety of cellular activities	mglA	-	3.6.3.17	ko:K10441,ko:K10542	ko02010,map02010	M00212,M00214	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19,3.A.1.2.3	-	-	ABC_tran
REGS2_k127_6915368_4	1449126.JQKL01000014_gene3022	1.613e-46	180.0	COG1307@1|root,COG1307@2|Bacteria,1TYCV@1239|Firmicutes,248JV@186801|Clostridia	186801|Clostridia	S	EDD domain protein, DegV family	-	-	-	-	-	-	-	-	-	-	-	-	DegV
REGS2_k127_6915368_1	1120746.CCNL01000017_gene2436	2.754e-146	484.0	COG4608@1|root,COG4608@2|Bacteria,2NP9Y@2323|unclassified Bacteria	2|Bacteria	E	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
REGS2_k127_6915368_2	1195236.CTER_1543	9.806e-138	445.0	COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,247NN@186801|Clostridia,3WGTC@541000|Ruminococcaceae	186801|Clostridia	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
REGS2_k127_6915368_3	1120746.CCNL01000017_gene2438	3.298e-111	364.0	COG1173@1|root,COG1173@2|Bacteria,2NQ14@2323|unclassified Bacteria	2|Bacteria	EP	PFAM binding-protein-dependent transport systems inner membrane component	dppC	-	-	ko:K02034,ko:K12370,ko:K15582	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00324,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1,OppC_N
REGS2_k127_6928671_4	1121866.AUGK01000002_gene1459	6.042e-62	222.0	COG0631@1|root,COG0631@2|Bacteria,2GJ3M@201174|Actinobacteria,4CUGE@84998|Coriobacteriia	84998|Coriobacteriia	T	phosphatase 2C	-	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	BofC_C,PP2C,PP2C_2
REGS2_k127_6928671_0	502558.EGYY_28730	1.387e-247	794.0	COG0768@1|root,COG0772@1|root,COG0768@2|Bacteria,COG0772@2|Bacteria,2GJTI@201174|Actinobacteria,4CUFK@84998|Coriobacteriia	84998|Coriobacteriia	DM	Belongs to the SEDS family	-	-	-	-	-	-	-	-	-	-	-	-	FTSW_RODA_SPOVE,Transpeptidase
REGS2_k127_6928671_1	1034345.CAEM01000002_gene1193	1.117e-141	471.0	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,2GJ1J@201174|Actinobacteria,4CUKV@84998|Coriobacteriia	84998|Coriobacteriia	KLT	Kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
REGS2_k127_6928671_6	500153.JOEK01000002_gene383	2.055e-45	171.0	COG1926@1|root,COG1926@2|Bacteria,2GJUU@201174|Actinobacteria	201174|Actinobacteria	Q	phosphoribosyltransferase	-	-	-	ko:K07100	-	-	-	-	ko00000	-	-	-	DLH,Pribosyltran
REGS2_k127_6928671_5	479434.Sthe_1371	2.602e-60	217.0	COG0639@1|root,COG0639@2|Bacteria	2|Bacteria	T	phosphoprotein phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos_2
REGS2_k127_6928671_12	1122223.KB890696_gene374	8.586e-13	72.0	COG0640@1|root,COG0640@2|Bacteria,1WK5H@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_20,HTH_5
REGS2_k127_6928671_9	351627.Csac_0498	2.853e-21	95.0	COG0526@1|root,COG0526@2|Bacteria,1VEYC@1239|Firmicutes,24QMF@186801|Clostridia,42H6Q@68295|Thermoanaerobacterales	186801|Clostridia	CO	redox-active disulfide protein 2	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_3
REGS2_k127_6928671_2	913865.DOT_1140	7.728e-131	424.0	COG0701@1|root,COG0701@2|Bacteria,1TQC7@1239|Firmicutes,24A02@186801|Clostridia,26085@186807|Peptococcaceae	186801|Clostridia	S	Predicted permease	-	-	-	ko:K07089	-	-	-	-	ko00000	-	-	-	ArsP_1
REGS2_k127_6928671_11	635013.TherJR_0468	9.312e-18	90.0	COG0526@1|root,COG0526@2|Bacteria	2|Bacteria	CO	cell redox homeostasis	resA	-	-	ko:K02199,ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	AhpC-TSA,Redoxin,Thioredoxin
REGS2_k127_6928671_8	635013.TherJR_2574	4.545e-31	134.0	COG4232@1|root,COG4232@2|Bacteria,1V9UQ@1239|Firmicutes,24DK4@186801|Clostridia,262P8@186807|Peptococcaceae	186801|Clostridia	CO	cytochrome c biogenesis protein, transmembrane region	-	-	-	ko:K06196	-	-	-	-	ko00000,ko02000	5.A.1.2	-	-	DsbD,Thioredoxin
REGS2_k127_6928671_3	335543.Sfum_0266	4.62e-76	264.0	COG0500@1|root,COG2226@2|Bacteria,1MVXN@1224|Proteobacteria,42PQM@68525|delta/epsilon subdivisions,2WJIF@28221|Deltaproteobacteria,2MRCK@213462|Syntrophobacterales	28221|Deltaproteobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	HTH_20,Methyltransf_31
REGS2_k127_6928671_7	457570.Nther_0831	7.143e-40	155.0	2C91C@1|root,30CC5@2|Bacteria,1V1Z2@1239|Firmicutes,24HJH@186801|Clostridia	186801|Clostridia	S	Putative redox-active protein (C_GCAxxG_C_C)	-	-	-	-	-	-	-	-	-	-	-	-	C_GCAxxG_C_C
REGS2_k127_6928671_10	290397.Adeh_1024	2.219e-19	91.0	COG0640@1|root,COG0640@2|Bacteria,1N7I7@1224|Proteobacteria,42VTU@68525|delta/epsilon subdivisions,2WRGJ@28221|Deltaproteobacteria,2YVHK@29|Myxococcales	28221|Deltaproteobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_20,HTH_5
REGS2_k127_6961244_11	502558.EGYY_12130	3.266e-56	203.0	COG1941@1|root,COG1941@2|Bacteria,2GSPN@201174|Actinobacteria,4CUTN@84998|Coriobacteriia	84998|Coriobacteriia	C	NADH ubiquinone oxidoreductase, 20 Kd subunit	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_q6
REGS2_k127_6961244_4	479437.Elen_1256	1.639e-127	420.0	COG3259@1|root,COG3259@2|Bacteria,2GQ33@201174|Actinobacteria,4CVBM@84998|Coriobacteriia	84998|Coriobacteriia	C	Nickel-dependent hydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	NiFeSe_Hases
REGS2_k127_6961244_6	697281.Mahau_1153	2.39e-123	411.0	COG4656@1|root,COG4656@2|Bacteria,1TPCC@1239|Firmicutes,24805@186801|Clostridia,42FFC@68295|Thermoanaerobacterales	186801|Clostridia	C	Part of a membrane complex involved in electron transport	rnfC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03615	-	-	-	-	ko00000	-	-	-	Complex1_51K,Fer4_10,RnfC_N,SLBB
REGS2_k127_6961244_9	555079.Toce_0699	8.699e-68	258.0	COG4658@1|root,COG4658@2|Bacteria,1TQAY@1239|Firmicutes,247TM@186801|Clostridia,42FR3@68295|Thermoanaerobacterales	186801|Clostridia	C	Part of a membrane complex involved in electron transport	rnfD	-	-	ko:K03614	-	-	-	-	ko00000	-	-	-	NQR2_RnfD_RnfE
REGS2_k127_6961244_20	515622.bpr_I2029	6.473e-18	91.0	COG4659@1|root,COG4659@2|Bacteria,1V4CE@1239|Firmicutes,25CQS@186801|Clostridia,4BXPJ@830|Butyrivibrio	186801|Clostridia	C	FMN_bind	rnfG	-	-	ko:K03612	-	-	-	-	ko00000	-	-	-	FMN_bind
REGS2_k127_6961244_14	457396.CSBG_01878	3.356e-49	186.0	COG4660@1|root,COG4660@2|Bacteria,1TSE7@1239|Firmicutes,24972@186801|Clostridia,36F7B@31979|Clostridiaceae	186801|Clostridia	C	Part of a membrane complex involved in electron transport	rnfE	-	-	ko:K03613	-	-	-	-	ko00000	-	-	iHN637.CLJU_RS05585	Rnf-Nqr
REGS2_k127_6961244_12	717231.Flexsi_1445	3.742e-54	196.0	COG4657@1|root,COG4657@2|Bacteria,2GETG@200930|Deferribacteres	200930|Deferribacteres	C	Part of a membrane complex involved in electron transport	-	-	-	ko:K03617	-	-	-	-	ko00000	-	-	-	Rnf-Nqr
REGS2_k127_6961244_10	555079.Toce_0703	7.883e-65	235.0	COG1036@1|root,COG1142@1|root,COG2878@1|root,COG1036@2|Bacteria,COG1142@2|Bacteria,COG2878@2|Bacteria,1TQGD@1239|Firmicutes,24904@186801|Clostridia,42G67@68295|Thermoanaerobacterales	186801|Clostridia	C	TIGRFAM electron transport complex, RnfABCDGE type, B subunit	rnfB	-	-	ko:K03616	-	-	-	-	ko00000	-	-	-	FeS,Fer4,Fer4_13,Fer4_4,Fer4_9
REGS2_k127_6961244_21	1125701.HMPREF1221_02051	1.919e-13	74.0	COG5341@1|root,COG5341@2|Bacteria,2J8UX@203691|Spirochaetes	203691|Spirochaetes	S	NusG domain II	-	-	-	-	-	-	-	-	-	-	-	-	NusG_II
REGS2_k127_6961244_23	1232443.BAIA02000084_gene781	1.727e-09	67.0	COG4769@1|root,COG4769@2|Bacteria,1V1M0@1239|Firmicutes,24MZC@186801|Clostridia	186801|Clostridia	S	Heptaprenyl diphosphate synthase component I	-	-	2.5.1.30	ko:K00805	ko00900,ko01110,map00900,map01110	-	R09247	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	Hpre_diP_synt_I
REGS2_k127_6961244_15	349161.Dred_2549	1.42e-47	179.0	COG2003@1|root,COG2003@2|Bacteria,1TQ3K@1239|Firmicutes,2498Z@186801|Clostridia,25ZZS@186807|Peptococcaceae	186801|Clostridia	E	Belongs to the UPF0758 family	radC	-	-	ko:K03630	-	-	-	-	ko00000	-	-	-	RadC
REGS2_k127_6961244_1	742722.HMPREF9463_01721	2.936e-150	485.0	COG1077@1|root,COG1077@2|Bacteria,2GMD1@201174|Actinobacteria,4CU7F@84998|Coriobacteriia	84998|Coriobacteriia	D	Cell shape determining protein, MreB Mrl family	-	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
REGS2_k127_6961244_16	742722.HMPREF9463_01720	3.921e-45	175.0	COG1792@1|root,COG1792@2|Bacteria,2GJN0@201174|Actinobacteria,4CUZG@84998|Coriobacteriia	84998|Coriobacteriia	M	Involved in formation and maintenance of cell shape	mreC	-	-	ko:K03570	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreC
REGS2_k127_6961244_22	1463900.JOIX01000053_gene311	1.781e-12	79.0	COG2891@1|root,COG2891@2|Bacteria,2GN0I@201174|Actinobacteria	201174|Actinobacteria	M	rod shape-determining protein (MreD)	mreD	-	-	ko:K03571	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreD
REGS2_k127_6961244_3	866774.HMPREF9248_1086	4.776e-137	460.0	COG0768@1|root,COG0768@2|Bacteria,2GJ61@201174|Actinobacteria,4CUTW@84998|Coriobacteriia	84998|Coriobacteriia	M	Penicillin-binding protein 2	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
REGS2_k127_6961244_8	661087.HMPREF1008_01366	4.182e-95	324.0	COG0772@1|root,COG0772@2|Bacteria,2GK2G@201174|Actinobacteria,4CUE2@84998|Coriobacteriia	84998|Coriobacteriia	D	Belongs to the SEDS family	-	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
REGS2_k127_6961244_13	649764.HMPREF0762_00657	1.319e-49	190.0	COG3597@1|root,COG3597@2|Bacteria,2GZU9@201174|Actinobacteria,4CVH2@84998|Coriobacteriia	84998|Coriobacteriia	S	protein domain associated with	-	-	-	-	-	-	-	-	-	-	-	-	DUF697
REGS2_k127_6961244_0	471855.Shel_14180	4.693e-208	679.0	COG1032@1|root,COG1032@2|Bacteria,2GJY1@201174|Actinobacteria,4CUXU@84998|Coriobacteriia	84998|Coriobacteriia	C	Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
REGS2_k127_6961244_17	1232436.CAPF01000014_gene707	2.914e-36	148.0	COG5011@1|root,COG5011@2|Bacteria,2GIS7@201174|Actinobacteria,4CVV5@84998|Coriobacteriia	84998|Coriobacteriia	S	Uncharacterized protein conserved in bacteria (DUF2344)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2344
REGS2_k127_6961244_5	1157490.EL26_14005	1.839e-127	424.0	COG1530@1|root,COG1530@2|Bacteria,1TQS4@1239|Firmicutes,4HC3Q@91061|Bacilli	91061|Bacilli	J	ribonuclease, Rne Rng family	cafA	-	-	ko:K08301	-	-	-	-	ko00000,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
REGS2_k127_6961244_19	502558.EGYY_19920	9.603e-24	110.0	COG0261@1|root,COG0261@2|Bacteria,2IQ9A@201174|Actinobacteria,4CW6C@84998|Coriobacteriia	84998|Coriobacteriia	J	This protein binds to 23S rRNA in the presence of protein L20	rplU	-	-	ko:K02888	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21p
REGS2_k127_6961244_18	742818.HMPREF9451_01015	2.141e-34	133.0	COG0211@1|root,COG0211@2|Bacteria,2IQDI@201174|Actinobacteria,4CW85@84998|Coriobacteriia	84998|Coriobacteriia	J	Belongs to the bacterial ribosomal protein bL27 family	rpmA	-	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
REGS2_k127_6961244_2	370438.PTH_0833	2.466e-137	453.0	COG0536@1|root,COG0536@2|Bacteria,1TPX7@1239|Firmicutes,247SP@186801|Clostridia,25ZZB@186807|Peptococcaceae	186801|Clostridia	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	DUF1967,GTP1_OBG,MMR_HSR1
REGS2_k127_6961244_7	273068.TTE1277	2.818e-95	325.0	COG0263@1|root,COG0263@2|Bacteria,1TPG6@1239|Firmicutes,2486P@186801|Clostridia,42FBI@68295|Thermoanaerobacterales	186801|Clostridia	F	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate	proB	-	2.7.2.11	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	M00015	R00239	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,PUA
REGS2_k127_6969846_0	429009.Adeg_0387	5.611e-166	533.0	COG1775@1|root,COG1775@2|Bacteria,1TPEF@1239|Firmicutes,24A11@186801|Clostridia,42F0V@68295|Thermoanaerobacterales	186801|Clostridia	E	PFAM 2-hydroxyglutaryl-CoA dehydratase D-component	-	-	-	-	-	-	-	-	-	-	-	-	HGD-D
REGS2_k127_6969846_6	502558.EGYY_12320	2.242e-78	270.0	COG0077@1|root,COG0077@2|Bacteria,2GJQ5@201174|Actinobacteria,4CUEH@84998|Coriobacteriia	84998|Coriobacteriia	E	Prephenate dehydratase	-	-	4.2.1.51,5.4.99.5	ko:K04518,ko:K14170	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R00691,R01373,R01715	RC00360,RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,CM_2,PDT
REGS2_k127_6969846_9	1379698.RBG1_1C00001G0325	3.156e-48	194.0	COG2199@1|root,COG3706@2|Bacteria,2NPJ3@2323|unclassified Bacteria	2|Bacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,GAF_3,GGDEF,MASE3,PAS_3,PAS_4,Response_reg
REGS2_k127_6969846_16	349161.Dred_3316	1.414e-14	83.0	COG1196@1|root,COG1196@2|Bacteria,1VAV4@1239|Firmicutes,24NPU@186801|Clostridia,2633R@186807|Peptococcaceae	186801|Clostridia	D	Protein of unknown function (DUF4446)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4446
REGS2_k127_6969846_3	555079.Toce_0387	8.291e-83	283.0	COG1691@1|root,COG1691@2|Bacteria,1TP0Z@1239|Firmicutes,24815@186801|Clostridia,42FCC@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM 1-(5-Phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase	-	-	-	ko:K06898	-	-	-	-	ko00000	-	-	-	AIRC
REGS2_k127_6969846_2	404380.Gbem_3626	5.045e-88	306.0	COG1641@1|root,COG1641@2|Bacteria,1MUKU@1224|Proteobacteria,42MHQ@68525|delta/epsilon subdivisions,2WJAC@28221|Deltaproteobacteria,43U9E@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Belongs to the LarC family	-	-	4.99.1.12	ko:K09121	-	-	-	-	ko00000,ko01000	-	-	-	DUF111
REGS2_k127_6969846_4	521011.Mpal_2170	1.058e-80	278.0	COG1194@1|root,arCOG00462@2157|Archaea,2XSU9@28890|Euryarchaeota,2NBC3@224756|Methanomicrobia	224756|Methanomicrobia	L	PFAM HhH-GPD family protein	-	-	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
REGS2_k127_6969846_1	292459.STH2398	5.756e-119	411.0	COG0745@1|root,COG2202@1|root,COG5002@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG5002@2|Bacteria,1VRP7@1239|Firmicutes,24YHW@186801|Clostridia	186801|Clostridia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,Hpt,PAS_9,Response_reg
REGS2_k127_6969846_12	1128398.Curi_c13140	5.079e-32	128.0	COG0745@1|root,COG0745@2|Bacteria,1TPWS@1239|Firmicutes,25AZ2@186801|Clostridia,2691N@186813|unclassified Clostridiales	186801|Clostridia	KT	Transcriptional regulatory protein, C terminal	phoP	-	-	ko:K02483,ko:K07658,ko:K07668	ko02020,map02020	M00434,M00459	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
REGS2_k127_6969846_13	767817.Desgi_3626	5.133e-27	116.0	COG0745@1|root,COG0745@2|Bacteria,1TPWS@1239|Firmicutes,25AZ2@186801|Clostridia,2605V@186807|Peptococcaceae	186801|Clostridia	K	PFAM response regulator receiver	phoB	-	-	ko:K02483,ko:K07658,ko:K07668	ko02020,map02020	M00434,M00459	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
REGS2_k127_6969846_10	374847.Kcr_0887	1.339e-39	160.0	COG0109@1|root,arCOG00479@2157|Archaea	2157|Archaea	O	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	ctaB	GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	COX15-CtaA,UbiA
REGS2_k127_6969846_5	358220.C380_19995	1.143e-79	274.0	COG1028@1|root,COG1028@2|Bacteria,1R413@1224|Proteobacteria,2WEVQ@28216|Betaproteobacteria,4AESC@80864|Comamonadaceae	28216|Betaproteobacteria	IQ	Short-chain dehydrogenase reductase sdr	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
REGS2_k127_6969846_8	1304874.JAFY01000002_gene352	1.568e-50	207.0	COG0642@1|root,COG2205@2|Bacteria	1304874.JAFY01000002_gene352|-	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS2_k127_6969846_7	471855.Shel_27020	8.081e-73	267.0	COG0515@1|root,COG0515@2|Bacteria,2GJ1J@201174|Actinobacteria,4CUH6@84998|Coriobacteriia	84998|Coriobacteriia	KLT	Kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
REGS2_k127_6969846_11	266117.Rxyl_0026	5.415e-36	147.0	COG1716@1|root,COG1716@2|Bacteria,2GNU2@201174|Actinobacteria,4CQB6@84995|Rubrobacteria	84995|Rubrobacteria	T	Protein of unknown function (DUF2662)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3662,FHA
REGS2_k127_6969846_14	469378.Ccur_03330	9.262e-23	107.0	COG1716@1|root,COG1716@2|Bacteria,2HUX0@201174|Actinobacteria,4CVX4@84998|Coriobacteriia	84998|Coriobacteriia	T	FHA domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA
REGS2_k127_6969846_15	479437.Elen_3041	5.952e-21	98.0	COG0631@1|root,COG0631@2|Bacteria,2GJ3M@201174|Actinobacteria,4CUGE@84998|Coriobacteriia	84998|Coriobacteriia	T	phosphatase 2C	-	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	BofC_C,PP2C,PP2C_2
REGS2_k127_7093134_6	96561.Dole_1090	2.706e-23	109.0	COG0745@1|root,COG2804@1|root,COG0745@2|Bacteria,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2WKXB@28221|Deltaproteobacteria,2MMWV@213118|Desulfobacterales	28221|Deltaproteobacteria	T	General secretory system II protein E domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,T2SSE,T2SSE_N
REGS2_k127_7093134_3	720554.Clocl_0107	8.38e-51	187.0	COG1394@1|root,COG1394@2|Bacteria,1TQ1Y@1239|Firmicutes,247TC@186801|Clostridia,3WHIG@541000|Ruminococcaceae	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpD	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
REGS2_k127_7093134_1	340099.Teth39_2258	6.683e-221	695.0	COG1156@1|root,COG1156@2|Bacteria,1VSU1@1239|Firmicutes,2496H@186801|Clostridia,42FIF@68295|Thermoanaerobacterales	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit	atpB	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
REGS2_k127_7093134_0	555079.Toce_2042	1.122e-232	735.0	COG1155@1|root,COG1155@2|Bacteria,1TPGS@1239|Firmicutes,24882@186801|Clostridia,42ETB@68295|Thermoanaerobacterales	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit	-	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
REGS2_k127_7093134_8	1121335.Clst_0329	6.546e-10	70.0	COG1436@1|root,COG1436@2|Bacteria,1VAX7@1239|Firmicutes,24MXC@186801|Clostridia,3WKQT@541000|Ruminococcaceae	186801|Clostridia	C	ATP synthase, subunit F	atpF	-	-	ko:K02122	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_F
REGS2_k127_7093134_5	877414.ATWA01000004_gene522	1.445e-23	112.0	COG1527@1|root,COG1527@2|Bacteria,1U6WZ@1239|Firmicutes,249XD@186801|Clostridia,267RG@186813|unclassified Clostridiales	186801|Clostridia	C	ATP synthase (C/AC39) subunit	ntpC	-	-	ko:K02119	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_AC39
REGS2_k127_7093134_4	1123075.AUDP01000020_gene1464	8.245e-29	126.0	COG0636@1|root,COG0636@2|Bacteria,1V786@1239|Firmicutes,24HBF@186801|Clostridia,3WJD9@541000|Ruminococcaceae	186801|Clostridia	C	ATP synthase subunit C	ntpK	-	-	ko:K02124	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_C
REGS2_k127_7093134_2	572547.Amico_0802	1.363e-68	260.0	COG1269@1|root,COG1269@2|Bacteria,3T9PG@508458|Synergistetes	508458|Synergistetes	U	Belongs to the V-ATPase 116 kDa subunit family	-	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
REGS2_k127_7093134_7	1157490.EL26_21960	1.641e-16	83.0	COG4481@1|root,COG4481@2|Bacteria,1VEQ7@1239|Firmicutes,4HNHU@91061|Bacilli,278N5@186823|Alicyclobacillaceae	91061|Bacilli	S	Bacterial protein of unknown function (DUF951)	yyzM	-	-	-	-	-	-	-	-	-	-	-	DUF951
REGS2_k127_7093608_13	338966.Ppro_2725	1.163e-44	169.0	COG0642@1|root,COG2202@1|root,COG2202@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,43BSB@68525|delta/epsilon subdivisions,2X735@28221|Deltaproteobacteria,43TD7@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,SBP_bac_3
REGS2_k127_7093608_2	404380.Gbem_3239	1.201e-150	487.0	COG1914@1|root,COG1914@2|Bacteria,1N0XH@1224|Proteobacteria,43B4Q@68525|delta/epsilon subdivisions,2X6IC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	PFAM natural resistance-associated macrophage protein	-	-	-	-	-	-	-	-	-	-	-	-	Nramp
REGS2_k127_7093608_1	1111121.HMPREF1247_0746	1.076e-152	503.0	COG2239@1|root,COG2239@2|Bacteria,2GMMK@201174|Actinobacteria,4CUUS@84998|Coriobacteriia	84998|Coriobacteriia	P	Magnesium transporter	-	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE_N,PRC
REGS2_k127_7093608_14	326424.FRAAL6699	5.053e-43	170.0	COG0561@1|root,COG0561@2|Bacteria,2IRCG@201174|Actinobacteria,4EUX0@85013|Frankiales	201174|Actinobacteria	S	Haloacid dehalogenase domain protein hydrolase, type 3	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3
REGS2_k127_7093608_12	269799.Gmet_3176	4.971e-59	217.0	COG1085@1|root,COG1085@2|Bacteria,1MU3E@1224|Proteobacteria,42MP4@68525|delta/epsilon subdivisions,2WKT8@28221|Deltaproteobacteria,43S3R@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Galactose-1-phosphate uridyl transferase, N-terminal domain	galT	-	2.7.7.12	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	M00362,M00554,M00632	R00955	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4921,GalP_UDP_tr_C,GalP_UDP_transf
REGS2_k127_7093608_21	1282876.BAOK01000002_gene294	7.767e-12	74.0	COG0454@1|root,COG0456@2|Bacteria,1RDWU@1224|Proteobacteria,2U7KM@28211|Alphaproteobacteria,4BSMP@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
REGS2_k127_7093608_9	742818.HMPREF9451_00876	1.17e-73	259.0	COG0715@1|root,COG0715@2|Bacteria,2HVTJ@201174|Actinobacteria,4CXFN@84998|Coriobacteriia	84998|Coriobacteriia	P	ABC transporter, phosphonate, periplasmic substrate-binding protein	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
REGS2_k127_7093608_7	471855.Shel_02140	2.14e-80	275.0	COG1116@1|root,COG1116@2|Bacteria,2GN33@201174|Actinobacteria,4CVVA@84998|Coriobacteriia	84998|Coriobacteriia	P	ABC transporter, ATP-binding protein	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
REGS2_k127_7093608_8	742818.HMPREF9451_01508	1.62e-76	274.0	COG0600@1|root,COG0600@2|Bacteria,2GKKZ@201174|Actinobacteria,4CX3H@84998|Coriobacteriia	84998|Coriobacteriia	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
REGS2_k127_7093608_5	1313172.YM304_31890	1.628e-124	428.0	COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria,4CMX3@84992|Acidimicrobiia	84992|Acidimicrobiia	P	E1-E2 ATPase	copA	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K12956	-	-	R00086	RC00002	ko00000,ko01000	3.A.3,3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
REGS2_k127_7093608_18	404589.Anae109_1224	1.275e-28	128.0	COG2836@1|root,COG2836@2|Bacteria,1RIGJ@1224|Proteobacteria,42Q44@68525|delta/epsilon subdivisions,2WRKT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Cytochrome C biogenesis protein transmembrane region	-	-	-	ko:K09792	-	-	-	-	ko00000	-	-	-	DsbD_2
REGS2_k127_7093608_6	1121456.ATVA01000015_gene2497	1.318e-113	390.0	COG2010@1|root,COG2993@1|root,COG2010@2|Bacteria,COG2993@2|Bacteria,1MXEY@1224|Proteobacteria,42NZG@68525|delta/epsilon subdivisions,2X2AA@28221|Deltaproteobacteria,2MF3K@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Cytochrome C oxidase, mono-heme subunit/FixO	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3,FixO
REGS2_k127_7093608_4	1121456.ATVA01000015_gene2498	7.341e-134	444.0	COG3278@1|root,COG3278@2|Bacteria,1MU18@1224|Proteobacteria,42M5M@68525|delta/epsilon subdivisions,2WM27@28221|Deltaproteobacteria,2MEJA@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	Cytochrome C and Quinol oxidase polypeptide I	ccoN	-	1.9.3.1	ko:K00404	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	COX1
REGS2_k127_7093608_23	255470.cbdbA1171	5.057e-05	53.0	2A3IT@1|root,30S1U@2|Bacteria,2GAWI@200795|Chloroflexi,34DHE@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Protein of unknown function (DUF2892)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2892
REGS2_k127_7093608_11	68170.KL590558_gene5402	6.375e-60	222.0	COG2770@1|root,COG5002@1|root,COG2770@2|Bacteria,COG5002@2|Bacteria,2GIX7@201174|Actinobacteria,4E0BU@85010|Pseudonocardiales	201174|Actinobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	2.7.13.3	ko:K07642	ko02020,map02020	M00450,M00645,M00646,M00648	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
REGS2_k127_7093608_10	401526.TcarDRAFT_2380	3.367e-69	241.0	COG0745@1|root,COG0745@2|Bacteria,1U3FH@1239|Firmicutes,4H3RA@909932|Negativicutes	909932|Negativicutes	T	PFAM response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
REGS2_k127_7093608_22	1089548.KI783301_gene1696	3.493e-10	72.0	2BIVC@1|root,32D3E@2|Bacteria,1VN3B@1239|Firmicutes,4I7VC@91061|Bacilli,3WFSW@539002|Bacillales incertae sedis	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS2_k127_7093608_19	573370.DMR_11230	2.154e-19	99.0	COG1433@1|root,COG1433@2|Bacteria,1RDPR@1224|Proteobacteria,42SR6@68525|delta/epsilon subdivisions,2WPP8@28221|Deltaproteobacteria,2MBY2@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM Dinitrogenase iron-molybdenum cofactor biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	Nitro_FeMo-Co
REGS2_k127_7093608_16	243231.GSU2146	2.577e-30	132.0	COG3439@1|root,COG3439@2|Bacteria,1RHJQ@1224|Proteobacteria,42X8S@68525|delta/epsilon subdivisions	1224|Proteobacteria	S	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	DUF302
REGS2_k127_7093608_20	926569.ANT_29600	6.677e-12	70.0	COG0695@1|root,COG1225@1|root,COG0695@2|Bacteria,COG1225@2|Bacteria,2G6XD@200795|Chloroflexi	200795|Chloroflexi	O	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
REGS2_k127_7093608_24	1157708.KB907458_gene1724	9.115e-05	53.0	COG3311@1|root,COG3311@2|Bacteria,1N72I@1224|Proteobacteria,2VVVG@28216|Betaproteobacteria,4AJJY@80864|Comamonadaceae	28216|Betaproteobacteria	L	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17
REGS2_k127_7093608_17	1380408.AVGH01000018_gene947	3.869e-29	128.0	2C5TN@1|root,30GQP@2|Bacteria,1V4GH@1239|Firmicutes,4HJ3A@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS2_k127_7093608_3	857293.CAAU_1175	7.284e-142	460.0	COG0798@1|root,COG0798@2|Bacteria,1TRMD@1239|Firmicutes,24958@186801|Clostridia,36FGQ@31979|Clostridiaceae	186801|Clostridia	P	TIGRFAM Arsenical-resistance protein	arsB	-	-	ko:K03325	-	-	-	-	ko00000,ko02000	2.A.59	-	-	SBF
REGS2_k127_7093608_0	62928.azo2356	1.91e-209	670.0	COG0003@1|root,COG0003@2|Bacteria,1MUTX@1224|Proteobacteria,2VK65@28216|Betaproteobacteria,2KUEH@206389|Rhodocyclales	206389|Rhodocyclales	P	Anion-transporting ATPase	arsA	-	3.6.3.16	ko:K01551	-	-	-	-	ko00000,ko01000,ko02000	3.A.19.1,3.A.21.1,3.A.4.1	-	-	ArsA_ATPase,CbiA
REGS2_k127_7093608_15	589865.DaAHT2_0581	9.998e-32	126.0	2DMHQ@1|root,32RMG@2|Bacteria,1RI3A@1224|Proteobacteria,42V0J@68525|delta/epsilon subdivisions,2WRQ5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Arsenical resistance operon trans-acting repressor ArsD	-	-	-	-	-	-	-	-	-	-	-	-	ArsD
REGS2_k127_7122991_6	1384484.AEQU_0872	1.921e-46	171.0	COG2265@1|root,COG2265@2|Bacteria,2GIR3@201174|Actinobacteria,4CUDT@84998|Coriobacteriia	84998|Coriobacteriia	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	rumA	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
REGS2_k127_7122991_11	269797.Mbar_A0260	7.636e-18	90.0	COG4892@1|root,arCOG02922@2157|Archaea,2Y64K@28890|Euryarchaeota,2NBAN@224756|Methanomicrobia	2157|Archaea	S	Cytochrome b5-like Heme/Steroid binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Cyt-b5
REGS2_k127_7122991_9	1485545.JQLW01000007_gene789	8.353e-33	136.0	COG0664@1|root,COG0664@2|Bacteria,1MXID@1224|Proteobacteria	1224|Proteobacteria	K	COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
REGS2_k127_7122991_7	477974.Daud_0172	2.772e-44	171.0	COG1011@1|root,COG1011@2|Bacteria,1UIE8@1239|Firmicutes,24I5V@186801|Clostridia,262HP@186807|Peptococcaceae	186801|Clostridia	S	Haloacid dehalogenase-like hydrolase	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
REGS2_k127_7122991_3	469378.Ccur_08550	6.113e-72	250.0	COG1740@1|root,COG1740@2|Bacteria,2GKF2@201174|Actinobacteria,4CV4A@84998|Coriobacteriia	84998|Coriobacteriia	C	NiFe/NiFeSe hydrogenase small subunit C-terminal	-	-	1.12.99.6	ko:K06282	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFe_hyd_SSU_C,Oxidored_q6
REGS2_k127_7122991_8	742742.HMPREF9452_01180	2.255e-33	132.0	COG1740@1|root,COG1740@2|Bacteria,2GKF2@201174|Actinobacteria,4CV4A@84998|Coriobacteriia	84998|Coriobacteriia	C	NiFe/NiFeSe hydrogenase small subunit C-terminal	-	-	1.12.99.6	ko:K06282	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFe_hyd_SSU_C,Oxidored_q6
REGS2_k127_7122991_1	469378.Ccur_08540	8.218e-182	582.0	COG0374@1|root,COG0374@2|Bacteria,2GKQY@201174|Actinobacteria,4CVAH@84998|Coriobacteriia	84998|Coriobacteriia	C	Nickel-dependent hydrogenase	-	-	1.12.99.6	ko:K06281	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
REGS2_k127_7122991_4	742742.HMPREF9452_01182	1.013e-54	199.0	COG1969@1|root,COG1969@2|Bacteria,2GUTZ@201174|Actinobacteria,4CUB3@84998|Coriobacteriia	84998|Coriobacteriia	C	Cytochrome b/b6/petB	-	-	-	ko:K03620	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	Ni_hydr_CYTB
REGS2_k127_7122991_2	479437.Elen_0037	3.25e-155	504.0	COG0635@1|root,COG0635@2|Bacteria,2GJ2W@201174|Actinobacteria,4CVEC@84998|Coriobacteriia	84998|Coriobacteriia	H	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
REGS2_k127_7122991_10	742818.HMPREF9451_00986	1.387e-29	125.0	COG0680@1|root,COG0680@2|Bacteria,2GSEX@201174|Actinobacteria,4CW0K@84998|Coriobacteriia	84998|Coriobacteriia	C	hydrogenase maturation protease	-	-	-	ko:K03605	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	HycI
REGS2_k127_7122991_0	515635.Dtur_0183	4.767e-183	606.0	COG0021@1|root,COG0021@2|Bacteria	2|Bacteria	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	tkt	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
REGS2_k127_7122991_5	290397.Adeh_3387	2.285e-51	193.0	COG0483@1|root,COG0483@2|Bacteria,1MUQT@1224|Proteobacteria,42R1W@68525|delta/epsilon subdivisions,2WMQ4@28221|Deltaproteobacteria,2YVHS@29|Myxococcales	28221|Deltaproteobacteria	G	Inositol monophosphatase	suhB	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
REGS2_k127_7122991_12	1449355.JQNR01000005_gene4825	1.048e-05	57.0	COG0276@1|root,COG0276@2|Bacteria,2GJTQ@201174|Actinobacteria	201174|Actinobacteria	H	Catalyzes the ferrous insertion into protoporphyrin IX	hemH	GO:0003674,GO:0003824,GO:0004325,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016020,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0040007,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0046148,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051537,GO:0051540,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	Ferrochelatase
REGS2_k127_7124909_6	1035308.AQYY01000001_gene2165	3.201e-86	293.0	COG1131@1|root,COG1131@2|Bacteria,1TRJH@1239|Firmicutes,247XQ@186801|Clostridia	186801|Clostridia	V	Abc transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
REGS2_k127_7124909_5	1035308.AQYY01000001_gene2164	1.568e-113	389.0	COG0842@1|root,COG0842@2|Bacteria,1TQG7@1239|Firmicutes,249TT@186801|Clostridia,261AQ@186807|Peptococcaceae	186801|Clostridia	U	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
REGS2_k127_7124909_3	1035308.AQYY01000001_gene2163	5.073e-125	410.0	COG0842@1|root,COG0842@2|Bacteria,1TQG7@1239|Firmicutes,249TT@186801|Clostridia,261AQ@186807|Peptococcaceae	186801|Clostridia	U	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
REGS2_k127_7124909_4	1035308.AQYY01000001_gene2162	9.604e-124	403.0	COG1131@1|root,COG1131@2|Bacteria,1TQKM@1239|Firmicutes,25B35@186801|Clostridia,26089@186807|Peptococcaceae	186801|Clostridia	V	PFAM ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
REGS2_k127_7124909_15	1283299.AUKG01000002_gene4701	6.57e-11	75.0	COG1309@1|root,COG1309@2|Bacteria,2HPYU@201174|Actinobacteria,4CRE0@84995|Rubrobacteria	84995|Rubrobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
REGS2_k127_7124909_1	264732.Moth_2310	1.711e-161	521.0	COG2509@1|root,COG2509@2|Bacteria,1TP9I@1239|Firmicutes,247QM@186801|Clostridia,42FH5@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM FAD dependent oxidoreductase	-	-	-	ko:K07137	-	-	-	-	ko00000	-	-	-	FAD_binding_2,HI0933_like,Pyr_redox_2,Thi4
REGS2_k127_7124909_14	694431.DESACE_02190	1.77e-18	89.0	COG0695@1|root,COG0695@2|Bacteria,1NGUN@1224|Proteobacteria,42VF8@68525|delta/epsilon subdivisions,2WT7Q@28221|Deltaproteobacteria,2M7BG@213113|Desulfurellales	28221|Deltaproteobacteria	O	Glutathione S-transferase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Glutaredoxin
REGS2_k127_7124909_2	649764.HMPREF0762_01171	3.595e-132	436.0	COG0305@1|root,COG0305@2|Bacteria,2GKXQ@201174|Actinobacteria,4CUUP@84998|Coriobacteriia	84998|Coriobacteriia	L	Participates in initiation and elongation during chromosome replication	dnaB	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
REGS2_k127_7124909_9	742722.HMPREF9463_00043	1.57e-41	161.0	COG0359@1|root,COG0359@2|Bacteria,2IKX7@201174|Actinobacteria,4CVTT@84998|Coriobacteriia	84998|Coriobacteriia	J	Binds to the 23S rRNA	rplI	-	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
REGS2_k127_7124909_16	661087.HMPREF1008_00476	3.982e-08	64.0	2CA7H@1|root,3494R@2|Bacteria,2HTSV@201174|Actinobacteria,4CW7G@84998|Coriobacteriia	84998|Coriobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2232
REGS2_k127_7124909_10	521095.Apar_0021	2.883e-35	139.0	COG0238@1|root,COG0238@2|Bacteria,2IQ92@201174|Actinobacteria,4CW67@84998|Coriobacteriia	84998|Coriobacteriia	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit	rpsR	-	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
REGS2_k127_7124909_11	649764.HMPREF0762_01175	8.819e-34	138.0	COG0629@1|root,COG0629@2|Bacteria,2GMM3@201174|Actinobacteria,4CVY5@84998|Coriobacteriia	84998|Coriobacteriia	L	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism	-	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
REGS2_k127_7124909_12	742722.HMPREF9463_00040	5.554e-30	122.0	COG0360@1|root,COG0360@2|Bacteria,2IQHD@201174|Actinobacteria,4CW8C@84998|Coriobacteriia	84998|Coriobacteriia	J	Binds together with S18 to 16S ribosomal RNA	rpsF	-	-	ko:K02990	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S6
REGS2_k127_7124909_18	1123240.ATVO01000004_gene1107	5.363e-05	55.0	COG4942@1|root,COG4942@2|Bacteria,1RD24@1224|Proteobacteria,2TUNI@28211|Alphaproteobacteria,2K0K8@204457|Sphingomonadales	204457|Sphingomonadales	DM	COG0739 Membrane proteins related to metalloendopeptidases	-	-	-	-	-	-	-	-	-	-	-	-	LysM,Peptidase_M23
REGS2_k127_7124909_13	1280692.AUJL01000019_gene888	6.867e-25	115.0	2EDRU@1|root,337MD@2|Bacteria,1VIEE@1239|Firmicutes,24P45@186801|Clostridia,36KTK@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS2_k127_7124909_0	697281.Mahau_2866	3.746e-170	548.0	COG0168@1|root,COG0168@2|Bacteria,1TPAF@1239|Firmicutes,248K4@186801|Clostridia,42GHF@68295|Thermoanaerobacterales	186801|Clostridia	P	PFAM cation transporter	trkH	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
REGS2_k127_7124909_8	1384484.AEQU_0135	3.716e-52	192.0	COG0569@1|root,COG0569@2|Bacteria,2GKB9@201174|Actinobacteria,4CUFJ@84998|Coriobacteriia	84998|Coriobacteriia	C	TrkA-N domain	-	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
REGS2_k127_7124909_7	1384484.AEQU_0134	4.196e-66	233.0	COG0569@1|root,COG0569@2|Bacteria,2GK4N@201174|Actinobacteria,4CUHI@84998|Coriobacteriia	84998|Coriobacteriia	C	TrkA-N domain	-	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_N
REGS2_k127_7141369_13	401053.AciPR4_1481	3.927e-07	62.0	COG2246@1|root,COG2246@2|Bacteria,3Y5R8@57723|Acidobacteria,2JK12@204432|Acidobacteriia	204432|Acidobacteriia	S	GtrA-like protein	-	-	-	-	-	-	-	-	-	-	-	-	GtrA
REGS2_k127_7141369_4	1165096.ARWF01000001_gene479	2.427e-125	410.0	COG0463@1|root,COG0463@2|Bacteria,1MWE5@1224|Proteobacteria,2VIY2@28216|Betaproteobacteria,2KPA2@206350|Nitrosomonadales	206350|Nitrosomonadales	M	Glycosyl transferase family 2	-	-	-	ko:K20534	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.2.1.9	GT2	-	Glycos_transf_2
REGS2_k127_7141369_11	553220.CAMGR0001_0395	4.522e-36	149.0	COG0647@1|root,COG0647@2|Bacteria,1QGX4@1224|Proteobacteria,42RAQ@68525|delta/epsilon subdivisions,2YPDH@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	G	COGs COG0647 sugar phosphatase of the HAD superfamily	-	-	3.1.3.41	ko:K01101	ko00627,ko01120,map00627,map01120	-	R03024	RC00151	ko00000,ko00001,ko01000	-	-	-	Hydrolase_6,Hydrolase_like
REGS2_k127_7141369_10	886293.Sinac_3932	1.164e-77	272.0	COG3836@1|root,COG3836@2|Bacteria	2|Bacteria	G	2-keto-3-deoxy-L-rhamnonate aldolase activity	-	-	4.1.2.52	ko:K02510	ko00350,ko01120,map00350,map01120	-	R01645,R01647	RC00307,RC00572,RC00574,RC03057	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
REGS2_k127_7141369_0	886293.Sinac_3931	1.234e-214	682.0	COG0028@1|root,COG0028@2|Bacteria,2IXMU@203682|Planctomycetes	2|Bacteria	H	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	ilvB2	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
REGS2_k127_7141369_9	1349822.NSB1T_00335	6.331e-82	282.0	COG0451@1|root,COG0451@2|Bacteria,4P3CP@976|Bacteroidetes,2FY1H@200643|Bacteroidia	976|Bacteroidetes	GM	RmlD substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
REGS2_k127_7141369_1	316067.Geob_2126	6.919e-200	634.0	COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,42MA3@68525|delta/epsilon subdivisions,2WM1D@28221|Deltaproteobacteria,43SU4@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	DegT/DnrJ/EryC1/StrS aminotransferase family	ddhC	-	1.17.1.1	ko:K12452	ko00520,map00520	-	R03391,R03392	RC00230	ko00000,ko00001,ko01000	-	-	-	DegT_DnrJ_EryC1
REGS2_k127_7141369_5	1172188.KB911826_gene239	2.322e-124	411.0	COG0451@1|root,COG0451@2|Bacteria	2|Bacteria	GM	ADP-glyceromanno-heptose 6-epimerase activity	rfbG	-	4.2.1.45	ko:K01709	ko00520,map00520	-	R02426	RC00402	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
REGS2_k127_7141369_6	404380.Gbem_0855	1.973e-120	394.0	COG1208@1|root,COG1208@2|Bacteria,1MUYJ@1224|Proteobacteria,42MCW@68525|delta/epsilon subdivisions,2WIYK@28221|Deltaproteobacteria,43SW1@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Nucleotidyl transferase	ddhA	-	2.7.7.33	ko:K00978	ko00500,ko00520,ko01100,map00500,map00520,map01100	-	R00956	RC00002	ko00000,ko00001,ko01000	-	-	-	NTP_transferase
REGS2_k127_7141369_8	1414720.CBYM010000034_gene1900	7.188e-90	304.0	COG1210@1|root,COG1210@2|Bacteria,1TQ24@1239|Firmicutes,25E5A@186801|Clostridia,36EIH@31979|Clostridiaceae	186801|Clostridia	M	UTP-glucose-1-phosphate uridylyltransferase	galU	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
REGS2_k127_7141369_3	469378.Ccur_12310	2.113e-179	572.0	COG0001@1|root,COG0001@2|Bacteria,2GJSH@201174|Actinobacteria,4CVGS@84998|Coriobacteriia	84998|Coriobacteriia	H	PFAM aminotransferase class-III	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
REGS2_k127_7141369_7	469378.Ccur_12320	2.411e-94	320.0	COG1522@1|root,COG1522@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	nirD	-	-	-	-	-	-	-	-	-	-	-	HTH_AsnC-type
REGS2_k127_7141369_12	266117.Rxyl_1043	8.165e-26	124.0	COG5650@1|root,COG5650@2|Bacteria,2HYCN@201174|Actinobacteria,4CQKH@84995|Rubrobacteria	84995|Rubrobacteria	S	Glycosyltransferase family 87	-	-	-	-	-	-	-	-	-	-	-	-	GT87
REGS2_k127_7141369_2	469378.Ccur_12330	6.163e-187	593.0	COG0535@1|root,COG0535@2|Bacteria,2GNSY@201174|Actinobacteria,4CUKZ@84998|Coriobacteriia	84998|Coriobacteriia	C	Iron-sulfur cluster-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM,SPASM
REGS2_k127_7449448_2	235909.GK3053	6.901e-30	128.0	COG3863@1|root,COG3863@2|Bacteria,1UFTY@1239|Firmicutes	1239|Firmicutes	S	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C92
REGS2_k127_7449448_0	479437.Elen_0567	1.742e-190	607.0	COG0498@1|root,COG0498@2|Bacteria,2GIRY@201174|Actinobacteria,4CV2R@84998|Coriobacteriia	84998|Coriobacteriia	E	Threonine synthase	thrC	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP,Thr_synth_N
REGS2_k127_7449448_1	311424.DhcVS_1517	4.696e-117	391.0	COG3635@1|root,COG3635@2|Bacteria,2GAQC@200795|Chloroflexi,34D2I@301297|Dehalococcoidia	301297|Dehalococcoidia	G	Metalloenzyme superfamily	-	-	5.4.2.12	ko:K15635	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,PhosphMutase
REGS2_k127_7458181_0	742818.HMPREF9451_00150	3.068e-316	983.0	COG0495@1|root,COG0495@2|Bacteria,2GJI1@201174|Actinobacteria,4CUPC@84998|Coriobacteriia	84998|Coriobacteriia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1
REGS2_k127_7458181_5	635013.TherJR_0120	5.48e-26	121.0	COG0484@1|root,COG0484@2|Bacteria	2|Bacteria	O	heat shock protein binding	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_c3_2,Cytochrome_C554,Cytochrome_C7,Paired_CXXCH_1
REGS2_k127_7458181_4	1121952.ATXT01000011_gene3001	7.355e-34	139.0	COG1555@1|root,COG1555@2|Bacteria,2IQDC@201174|Actinobacteria,4FPAM@85023|Microbacteriaceae	201174|Actinobacteria	L	SLBB domain	comEA	-	-	ko:K02237	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	HHH_3,SLBB
REGS2_k127_7458181_2	1504822.CCNO01000015_gene828	7.607e-54	217.0	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,2NP4I@2323|unclassified Bacteria	2|Bacteria	U	Metallo-beta-lactamase superfamily	comEC	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
REGS2_k127_7458181_3	1235794.C811_00656	9.762e-43	171.0	COG1466@1|root,COG1466@2|Bacteria,2HUP4@201174|Actinobacteria,4CV9D@84998|Coriobacteriia	84998|Coriobacteriia	L	DNA polymerase III, delta' subunit	holA	-	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta
REGS2_k127_7458181_6	1194165.CAJF01000002_gene2105	8.516e-22	103.0	COG0268@1|root,COG0268@2|Bacteria,2IQ73@201174|Actinobacteria,4FPN2@85023|Microbacteriaceae	201174|Actinobacteria	J	Binds directly to 16S ribosomal RNA	rpsT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464	-	ko:K02968	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S20p
REGS2_k127_7458181_1	479437.Elen_1652	1.541e-297	921.0	COG0481@1|root,COG0481@2|Bacteria,2GJAB@201174|Actinobacteria,4CU7Q@84998|Coriobacteriia	84998|Coriobacteriia	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2,LepA_C
REGS2_k127_7516141_2	1121866.AUGK01000019_gene757	1.119e-159	512.0	COG0162@1|root,COG0162@2|Bacteria,2GJPR@201174|Actinobacteria,4CV92@84998|Coriobacteriia	84998|Coriobacteriia	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
REGS2_k127_7516141_3	401526.TcarDRAFT_1800	8.151e-135	461.0	COG0744@1|root,COG0744@2|Bacteria,1TPM5@1239|Firmicutes,4H360@909932|Negativicutes	909932|Negativicutes	M	Penicillin-binding Protein	pbpD	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
REGS2_k127_7516141_5	477974.Daud_1374	4.177e-131	449.0	COG0826@1|root,COG0826@2|Bacteria,1TQS1@1239|Firmicutes,24909@186801|Clostridia,260G6@186807|Peptococcaceae	186801|Clostridia	O	PFAM peptidase U32	ydcP	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3656,Peptidase_U32
REGS2_k127_7516141_4	1321773.HMPREF9069_01604	4.138e-133	449.0	COG0744@1|root,COG0744@2|Bacteria,2GK21@201174|Actinobacteria,4CUT9@84998|Coriobacteriia	84998|Coriobacteriia	M	penicillin-binding protein, 1A family	-	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	PASTA,Transgly,Transpeptidase
REGS2_k127_7516141_6	1449126.JQKL01000021_gene96	1.307e-98	344.0	COG0327@1|root,COG0327@2|Bacteria,1UK7Y@1239|Firmicutes,248IP@186801|Clostridia	186801|Clostridia	S	PFAM NIF3 (NGG1p interacting factor 3)	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS2_k127_7516141_8	868595.Desca_1210	4.979e-47	177.0	COG2094@1|root,COG2094@2|Bacteria,1V1E6@1239|Firmicutes,24FRV@186801|Clostridia,261K2@186807|Peptococcaceae	186801|Clostridia	L	Belongs to the DNA glycosylase MPG family	-	-	3.2.2.21	ko:K03652	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Pur_DNA_glyco
REGS2_k127_7516141_1	502558.EGYY_08860	1.188e-173	556.0	COG0165@1|root,COG0165@2|Bacteria,2GJ2A@201174|Actinobacteria,4CUGF@84998|Coriobacteriia	84998|Coriobacteriia	E	Argininosuccinate lyase C-terminal	argH	-	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
REGS2_k127_7516141_0	479437.Elen_2339	2.492e-183	586.0	COG0137@1|root,COG0137@2|Bacteria,2GK96@201174|Actinobacteria,4CV0T@84998|Coriobacteriia	84998|Coriobacteriia	E	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	-	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
REGS2_k127_7516141_9	1118060.CAGZ01000016_gene1807	3.764e-45	167.0	COG1438@1|root,COG1438@2|Bacteria,2GKA5@201174|Actinobacteria,4CVTV@84998|Coriobacteriia	84998|Coriobacteriia	K	Regulates arginine biosynthesis genes	argR	-	-	ko:K03402	-	-	-	-	ko00000,ko03000	-	-	-	Arg_repressor,Arg_repressor_C
REGS2_k127_7516141_7	986075.CathTA2_0576	9.051e-52	187.0	COG0078@1|root,COG0078@2|Bacteria,1TPF2@1239|Firmicutes,4H9X8@91061|Bacilli	91061|Bacilli	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
REGS2_k127_7807120_4	264732.Moth_1825	1.061e-56	222.0	COG0583@1|root,COG0583@2|Bacteria,1TSA6@1239|Firmicutes,24BM8@186801|Clostridia,42I6P@68295|Thermoanaerobacterales	186801|Clostridia	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
REGS2_k127_7807120_6	293826.Amet_1651	2.179e-26	119.0	COG0310@1|root,COG0310@2|Bacteria,1V6E4@1239|Firmicutes,24MBZ@186801|Clostridia	186801|Clostridia	P	Cobalt uptake substrate-specific transmembrane region	-	-	-	ko:K02007	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiM
REGS2_k127_7807120_8	207559.Dde_1192	3.703e-05	55.0	COG0619@1|root,COG0619@2|Bacteria,1RJIT@1224|Proteobacteria,42RU5@68525|delta/epsilon subdivisions,2WNB7@28221|Deltaproteobacteria,2MA26@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	TIGRFAM cobalt ABC transporter, inner membrane subunit CbiQ	cbiQ	-	-	ko:K02008	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiQ
REGS2_k127_7807120_3	1304880.JAGB01000003_gene1124	2.875e-74	271.0	COG1122@1|root,COG1122@2|Bacteria,1UYYS@1239|Firmicutes,25BN3@186801|Clostridia	186801|Clostridia	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K02006	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	ABC_tran
REGS2_k127_7807120_1	1041930.Mtc_0318	3.979e-107	360.0	COG0426@1|root,arCOG00509@2157|Archaea,2XSUD@28890|Euryarchaeota,2N9E8@224756|Methanomicrobia	224756|Methanomicrobia	C	Flavodoxin	fprA-1	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_1,Lactamase_B
REGS2_k127_7807120_0	469378.Ccur_03940	8.936e-128	430.0	COG0142@1|root,COG0142@2|Bacteria,2GN1P@201174|Actinobacteria,4CYEM@84998|Coriobacteriia	84998|Coriobacteriia	H	Belongs to the FPP GGPP synthase family	-	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13787	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
REGS2_k127_7807120_2	1125863.JAFN01000001_gene3130	6.228e-79	272.0	COG0390@1|root,COG0390@2|Bacteria,1MV2N@1224|Proteobacteria,42S2G@68525|delta/epsilon subdivisions,2X5PA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Uncharacterised protein family (UPF0014)	-	-	-	ko:K02069	-	M00211	-	-	ko00000,ko00002,ko02000	9.B.25.1	-	-	UPF0014
REGS2_k127_7807120_5	77635.BISU_1303	4.678e-45	171.0	COG1136@1|root,COG1136@2|Bacteria,2I8QP@201174|Actinobacteria,4CZZG@85004|Bifidobacteriales	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02068	-	M00211	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_tran
REGS2_k127_7807120_7	111780.Sta7437_1943	1.687e-17	85.0	COG2931@1|root,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF1735,HemolysinCabind,Laminin_G_3
REGS2_k127_7815305_1	246194.CHY_0707	3.424e-128	415.0	COG0069@1|root,COG0069@2|Bacteria,1TQ0B@1239|Firmicutes,248IB@186801|Clostridia,42EK3@68295|Thermoanaerobacterales	186801|Clostridia	C	Belongs to the glutamate synthase family	gltB	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4,Fer4_7,Fer4_9,Glu_syn_central,Glu_synthase
REGS2_k127_7815305_0	373903.Hore_16310	1.828e-144	468.0	COG0067@1|root,COG0067@2|Bacteria,1TQX1@1239|Firmicutes,24AKF@186801|Clostridia,3WB3R@53433|Halanaerobiales	186801|Clostridia	C	Glutamate synthase (NADPH) GltB1 subunit	-	-	-	-	-	-	-	-	-	-	-	-	GATase_2,GATase_6
REGS2_k127_7815305_3	246194.CHY_0714	2.678e-103	355.0	COG1150@1|root,COG2048@1|root,COG1150@2|Bacteria,COG2048@2|Bacteria,1V67B@1239|Firmicutes,248DI@186801|Clostridia,42H12@68295|Thermoanaerobacterales	186801|Clostridia	C	Cysteine-rich domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
REGS2_k127_7815305_8	768706.Desor_2169	7.049e-29	132.0	COG1280@1|root,COG1280@2|Bacteria,1V4SU@1239|Firmicutes,24KYP@186801|Clostridia,262BI@186807|Peptococcaceae	186801|Clostridia	E	PFAM Lysine exporter protein (LYSE YGGA)	-	-	-	-	-	-	-	-	-	-	-	-	LysE
REGS2_k127_7815305_10	555088.DealDRAFT_2813	0.0003691	51.0	28U8H@1|root,2ZGE4@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS2_k127_7815305_6	1120948.KB903240_gene4076	3.091e-64	227.0	COG3707@1|root,COG3707@2|Bacteria,2GK7T@201174|Actinobacteria,4DYAM@85010|Pseudonocardiales	201174|Actinobacteria	T	Response regulator receiver	pdtaR	GO:0000160,GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0007154,GO:0007165,GO:0008150,GO:0009987,GO:0016020,GO:0023052,GO:0030312,GO:0035556,GO:0040007,GO:0043167,GO:0043168,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071944	-	ko:K22010	-	M00839	-	-	ko00000,ko00002,ko02022	-	-	-	ANTAR,Response_reg
REGS2_k127_7815305_4	1240349.ANGC01000002_gene2193	2.787e-71	259.0	COG3920@1|root,COG3920@2|Bacteria,2GKMP@201174|Actinobacteria,4FZDD@85025|Nocardiaceae	201174|Actinobacteria	T	Signal transduction histidine kinase	pdtaS	GO:0000155,GO:0000160,GO:0000166,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005488,GO:0005524,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0017076,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035556,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564	2.7.13.3	ko:K00936	-	M00839	-	-	ko00000,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,H_kinase_N,HisKA_2,PAS_4
REGS2_k127_7815305_7	243231.GSU1007	5.002e-36	154.0	COG2203@1|root,COG2206@1|root,COG2203@2|Bacteria,COG2206@2|Bacteria,1RAQS@1224|Proteobacteria,42MEJ@68525|delta/epsilon subdivisions,2X71A@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	metal-dependent phosphohydrolase HD region	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,GAF_3,HAMP,HD,HD_5
REGS2_k127_7815305_9	1499967.BAYZ01000176_gene5677	4.719e-09	66.0	COG1413@1|root,COG5635@1|root,COG1413@2|Bacteria,COG5635@2|Bacteria	2|Bacteria	T	Nacht domain	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS,NACHT
REGS2_k127_7815305_5	1120960.ATXG01000005_gene2561	4.268e-68	249.0	COG0477@1|root,COG2814@2|Bacteria,2I7XA@201174|Actinobacteria,4FR3H@85023|Microbacteriaceae	201174|Actinobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
REGS2_k127_7815305_2	1120999.JONM01000030_gene3241	2.729e-125	409.0	COG1816@1|root,COG1816@2|Bacteria,1MWBV@1224|Proteobacteria,2VI56@28216|Betaproteobacteria,2KPNH@206351|Neisseriales	206351|Neisseriales	F	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism	add	-	3.5.4.2	ko:K21053	ko00230,ko01100,map00230,map01100	-	R01244	RC00477	ko00000,ko00001,ko01000	-	-	-	A_deaminase
REGS2_k127_7859113_4	635013.TherJR_0705	7.935e-177	574.0	COG0004@1|root,COG0004@2|Bacteria,1TQYG@1239|Firmicutes,247W1@186801|Clostridia,2615C@186807|Peptococcaceae	186801|Clostridia	P	TIGRFAM Ammonium transporter	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
REGS2_k127_7859113_13	292414.TM1040_1023	9.149e-36	139.0	COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,2U73Z@28211|Alphaproteobacteria,4NC8I@97050|Ruegeria	28211|Alphaproteobacteria	K	Belongs to the P(II) protein family	glnB	GO:0003674,GO:0006808,GO:0008150,GO:0030234,GO:0050789,GO:0050790,GO:0065007,GO:0065009,GO:0098772	-	ko:K04751	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
REGS2_k127_7859113_18	246194.CHY_1095	1.012e-07	56.0	COG0526@1|root,COG4232@1|root,COG0526@2|Bacteria,COG4232@2|Bacteria,1V7JP@1239|Firmicutes,25ET7@186801|Clostridia	186801|Clostridia	CO	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	-	ko:K06196	-	-	-	-	ko00000,ko02000	5.A.1.2	-	-	AhpC-TSA,Redoxin
REGS2_k127_7859113_15	316275.VSAL_II1056	5.844e-15	85.0	COG0607@1|root,COG0607@2|Bacteria,1RHVM@1224|Proteobacteria,1SD9C@1236|Gammaproteobacteria,1XXY0@135623|Vibrionales	135623|Vibrionales	M	COG0607 Rhodanese-related sulfurtransferase	pspE	-	-	ko:K03972	-	-	-	-	ko00000	-	-	-	Rhodanese
REGS2_k127_7859113_0	886293.Sinac_1249	0.0	2441.0	COG3459@1|root,COG3459@2|Bacteria,2IYJ0@203682|Planctomycetes	203682|Planctomycetes	G	Putative glucoamylase	-	-	-	ko:K13688	-	-	-	-	ko00000,ko01000,ko01003	-	GH94,GT84	-	Glyco_hydro_36,Glyco_transf_36,Glycoamylase
REGS2_k127_7859113_3	497965.Cyan7822_2288	3.65e-206	653.0	COG0737@1|root,COG0737@2|Bacteria,1GJ13@1117|Cyanobacteria,3KKIN@43988|Cyanothece	1117|Cyanobacteria	F	Belongs to the 5'-nucleotidase family	-	-	-	-	-	-	-	-	-	-	-	-	5_nucleotid_C,Metallophos
REGS2_k127_7859113_17	1235798.C817_01216	2.078e-08	62.0	2D5AS@1|root,32TIN@2|Bacteria,1VA4E@1239|Firmicutes,24JJQ@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_B561
REGS2_k127_7859113_19	1347369.CCAD010000067_gene3452	1.435e-05	50.0	2EG8N@1|root,33A0G@2|Bacteria,1VMHK@1239|Firmicutes,4HSIH@91061|Bacilli,1ZJWT@1386|Bacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS2_k127_7859113_12	1206739.BAGJ01000078_gene6528	7.099e-41	156.0	COG1259@1|root,COG1259@2|Bacteria,2GN26@201174|Actinobacteria,4FVJ2@85025|Nocardiaceae	201174|Actinobacteria	S	Bifunctional nuclease	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	ko:K08999	-	-	-	-	ko00000	-	-	-	DNase-RNase
REGS2_k127_7859113_7	1048339.KB913029_gene2313	3.8e-89	307.0	COG0577@1|root,COG0577@2|Bacteria,2GIRW@201174|Actinobacteria,4EUUS@85013|Frankiales	201174|Actinobacteria	V	MacB-like periplasmic core domain	yknZ	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
REGS2_k127_7859113_9	292459.STH976	1.622e-81	281.0	COG1136@1|root,COG1136@2|Bacteria,1TPBJ@1239|Firmicutes,248EZ@186801|Clostridia	186801|Clostridia	V	ABC transporter	macB	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
REGS2_k127_7859113_14	1408813.AYMG01000023_gene2028	4.958e-17	94.0	COG1566@1|root,COG1566@2|Bacteria,4PMCY@976|Bacteroidetes	976|Bacteroidetes	V	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	HlyD_D23
REGS2_k127_7859113_11	742818.HMPREF9451_00505	3.479e-51	189.0	COG0546@1|root,COG0546@2|Bacteria,2I9FC@201174|Actinobacteria,4CVWZ@84998|Coriobacteriia	84998|Coriobacteriia	S	IA, variant 3	-	-	3.6.1.1	ko:K06019	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	HAD_2
REGS2_k127_7859113_16	1283299.AUKG01000002_gene4134	1.661e-12	75.0	2EAFX@1|root,334J9@2|Bacteria,2IJSF@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS2_k127_7859113_1	1235794.C811_01923	0.0	1122.0	COG0188@1|root,COG0188@2|Bacteria,2GJ2Q@201174|Actinobacteria,4CU8E@84998|Coriobacteriia	84998|Coriobacteriia	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
REGS2_k127_7859113_2	1408422.JHYF01000006_gene1012	3.634e-263	825.0	COG0187@1|root,COG0187@2|Bacteria,1TQ0R@1239|Firmicutes,248AV@186801|Clostridia,36DYE@31979|Clostridiaceae	186801|Clostridia	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
REGS2_k127_7859113_8	1118060.CAGZ01000001_gene215	3.154e-85	295.0	COG1195@1|root,COG1195@2|Bacteria,2GJCS@201174|Actinobacteria,4CUNC@84998|Coriobacteriia	84998|Coriobacteriia	L	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP	recF	-	-	ko:K03629	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	SMC_N
REGS2_k127_7859113_6	1034345.CAEM01000002_gene1225	2.179e-102	344.0	COG0592@1|root,COG0592@2|Bacteria,2GJK3@201174|Actinobacteria,4CUF2@84998|Coriobacteriia	84998|Coriobacteriia	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	dnaN	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
REGS2_k127_7859113_5	997346.HMPREF9374_2517	4.027e-146	477.0	COG0593@1|root,COG0593@2|Bacteria,1TPV7@1239|Firmicutes,4H9MW@91061|Bacilli,27BH0@186824|Thermoactinomycetaceae	91061|Bacilli	L	Bacterial dnaA protein helix-turn-helix domain	dnaA	GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0042802,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
REGS2_k127_7859113_10	742818.HMPREF9451_01633	3.212e-61	221.0	COG1846@1|root,COG2172@1|root,COG1846@2|Bacteria,COG2172@2|Bacteria,2I4BY@201174|Actinobacteria,4CYKP@84998|Coriobacteriia	84998|Coriobacteriia	KT	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
REGS2_k127_8039673_2	502025.Hoch_2276	1.58e-119	407.0	COG0205@1|root,COG0205@2|Bacteria,1R560@1224|Proteobacteria,42P6N@68525|delta/epsilon subdivisions,2WINA@28221|Deltaproteobacteria,2YVFG@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfp	-	2.7.1.11,2.7.1.90	ko:K00895,ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
REGS2_k127_8039673_3	243231.GSU1402	2.818e-95	325.0	COG0825@1|root,COG0825@2|Bacteria,1MURN@1224|Proteobacteria,42NC2@68525|delta/epsilon subdivisions,2WKA3@28221|Deltaproteobacteria,43UDE@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA	accA	-	2.1.3.15,6.4.1.2	ko:K01962,ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	ACCA
REGS2_k127_8039673_4	648996.Theam_0308	2.96e-82	286.0	COG0777@1|root,COG0777@2|Bacteria,2G3MC@200783|Aquificae	200783|Aquificae	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA	accD	-	2.1.3.15,6.4.1.2	ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
REGS2_k127_8039673_1	1034345.CAEM01000002_gene1168	1.12e-150	489.0	COG1830@1|root,COG1830@2|Bacteria,2I9V1@201174|Actinobacteria,4CUCN@84998|Coriobacteriia	84998|Coriobacteriia	G	DeoC/LacD family aldolase	-	-	4.1.2.13	ko:K11645	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	DeoC
REGS2_k127_8039673_6	86416.Clopa_1943	6.278e-17	95.0	COG2153@1|root,COG2153@2|Bacteria,1UI7Y@1239|Firmicutes,24KCF@186801|Clostridia,36KCZ@31979|Clostridiaceae	186801|Clostridia	S	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10
REGS2_k127_8039673_0	1313172.YM304_38270	1.684e-165	543.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,2GK2C@201174|Actinobacteria,4CMPV@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	nadE	-	6.3.5.1	ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
REGS2_k127_8039673_5	926569.ANT_09090	1.059e-23	106.0	COG0745@1|root,COG4963@1|root,COG0745@2|Bacteria,COG4963@2|Bacteria,2G89B@200795|Chloroflexi	200795|Chloroflexi	D	Cellulose biosynthesis protein BcsQ	-	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	CBP_BcsQ,Response_reg
REGS2_k127_8106945_4	633147.Olsu_0999	1.654e-65	234.0	COG0196@1|root,COG0196@2|Bacteria,2GKQF@201174|Actinobacteria,4CUHV@84998|Coriobacteriia	84998|Coriobacteriia	H	riboflavin biosynthesis protein	ribF	-	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
REGS2_k127_8106945_5	661087.HMPREF1008_01585	6.753e-61	233.0	COG0130@1|root,COG0130@2|Bacteria,2GJZK@201174|Actinobacteria,4CUJN@84998|Coriobacteriia	84998|Coriobacteriia	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	-	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB_C_2,TruB_N
REGS2_k127_8106945_6	471855.Shel_09380	6.723e-53	200.0	COG0618@1|root,COG0618@2|Bacteria,2GN9Z@201174|Actinobacteria,4CUKD@84998|Coriobacteriia	84998|Coriobacteriia	S	DHHA1 domain	-	-	3.1.13.3,3.1.3.7	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
REGS2_k127_8106945_12	316067.Geob_2693	3.842e-14	84.0	COG0858@1|root,COG0858@2|Bacteria,1MZPE@1224|Proteobacteria,42U0Y@68525|delta/epsilon subdivisions,2WR00@28221|Deltaproteobacteria,43V4Z@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
REGS2_k127_8106945_0	1235794.C811_00453	7.353e-247	785.0	COG0532@1|root,COG0532@2|Bacteria,2GKPH@201174|Actinobacteria,4CUAY@84998|Coriobacteriia	84998|Coriobacteriia	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N
REGS2_k127_8106945_9	515635.Dtur_1207	4.757e-21	95.0	COG2740@1|root,COG2740@2|Bacteria	2|Bacteria	K	Nucleic-acid-binding protein implicated in transcription termination	ylxR	-	-	ko:K02600,ko:K07742	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	DUF448
REGS2_k127_8106945_3	471855.Shel_09350	6.328e-137	447.0	COG0195@1|root,COG0195@2|Bacteria,2GJDJ@201174|Actinobacteria,4CUWV@84998|Coriobacteriia	84998|Coriobacteriia	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_5,NusA_N
REGS2_k127_8106945_8	1235794.C811_00450	1.153e-35	143.0	COG0779@1|root,COG0779@2|Bacteria,2HUVT@201174|Actinobacteria,4CVTM@84998|Coriobacteriia	84998|Coriobacteriia	J	Required for maturation of 30S ribosomal subunits	rimP	-	-	ko:K09748	-	-	-	-	ko00000,ko03009	-	-	-	DUF150,DUF150_C
REGS2_k127_8106945_1	479437.Elen_2464	7.205e-231	729.0	COG0442@1|root,COG0442@2|Bacteria,2GJ9G@201174|Actinobacteria,4CUIZ@84998|Coriobacteriia	84998|Coriobacteriia	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
REGS2_k127_8106945_7	316067.Geob_0907	2.097e-37	147.0	COG4091@1|root,COG4091@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,MCPsignal,NAD_binding_3
REGS2_k127_8106945_10	1261545.MBE-HAL_1658	5.285e-18	92.0	COG0589@1|root,arCOG02053@2157|Archaea,2XZ47@28890|Euryarchaeota,23X59@183963|Halobacteria	183963|Halobacteria	T	COG0589 Universal stress protein UspA and related nucleotide-binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Usp
REGS2_k127_8106945_2	661478.OP10G_2584	2.31e-205	658.0	COG4147@1|root,COG4147@2|Bacteria	2|Bacteria	S	glycolate transport	-	-	-	ko:K14393	-	-	-	-	ko00000,ko02000	2.A.21.7	-	-	SSF
REGS2_k127_8106945_11	696281.Desru_0986	4.062e-16	82.0	2C2F3@1|root,33J8S@2|Bacteria,1W120@1239|Firmicutes,254DI@186801|Clostridia,265TH@186807|Peptococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS2_k127_817084_25	1304874.JAFY01000002_gene616	7.84e-34	141.0	COG4251@1|root,COG4251@2|Bacteria,3TCMP@508458|Synergistetes	2|Bacteria	T	GHKL domain	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	GAF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_7,PAS_9,Response_reg
REGS2_k127_817084_15	426117.M446_1526	4.309e-56	222.0	COG0642@1|root,COG2199@1|root,COG5002@1|root,COG2205@2|Bacteria,COG3706@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,2VDSR@28211|Alphaproteobacteria,1JRF8@119045|Methylobacteriaceae	28211|Alphaproteobacteria	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS_3,PAS_7,Response_reg
REGS2_k127_817084_10	323259.Mhun_2688	5.726e-63	243.0	COG0642@1|root,arCOG02329@1|root,arCOG02352@1|root,arCOG02329@2157|Archaea,arCOG02351@2157|Archaea,arCOG02352@2157|Archaea,2Y7MY@28890|Euryarchaeota,2NAHA@224756|Methanomicrobia	224756|Methanomicrobia	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_2,PAS_3,PAS_9,PocR
REGS2_k127_817084_27	936573.HMPREF1147_0247	4.85e-30	130.0	COG0212@1|root,COG0212@2|Bacteria,1VA91@1239|Firmicutes,4H57W@909932|Negativicutes	909932|Negativicutes	H	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family	fthC	-	6.3.3.2	ko:K01934	ko00670,ko01100,map00670,map01100	-	R02301	RC00183	ko00000,ko00001,ko01000	-	-	-	5-FTHF_cyc-lig
REGS2_k127_817084_14	479437.Elen_3002	9.348e-57	212.0	COG0726@1|root,COG0726@2|Bacteria,2GN6G@201174|Actinobacteria,4CUNY@84998|Coriobacteriia	84998|Coriobacteriia	G	polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
REGS2_k127_817084_29	1169161.KB897724_gene4933	2.334e-24	116.0	COG2606@1|root,COG2606@2|Bacteria,2IKUX@201174|Actinobacteria	201174|Actinobacteria	S	YbaK prolyl-tRNA synthetase associated region	-	-	-	-	-	-	-	-	-	-	-	-	tRNA_edit
REGS2_k127_817084_17	1449976.KALB_8831	2.295e-45	173.0	COG3153@1|root,COG3153@2|Bacteria,2GNNB@201174|Actinobacteria,4DXW4@85010|Pseudonocardiales	201174|Actinobacteria	S	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
REGS2_k127_817084_38	479437.Elen_2986	1.517e-08	65.0	COG3881@1|root,COG3881@2|Bacteria,2I6A5@201174|Actinobacteria,4CURS@84998|Coriobacteriia	84998|Coriobacteriia	S	PFAM PRC-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	PRC
REGS2_k127_817084_34	479437.Elen_2987	4.583e-10	68.0	COG4980@1|root,COG4980@2|Bacteria,2HTT2@201174|Actinobacteria,4CW82@84998|Coriobacteriia	84998|Coriobacteriia	S	YtxH-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YtxH
REGS2_k127_817084_5	1380390.JIAT01000009_gene1803	1.118e-90	312.0	COG1181@1|root,COG1181@2|Bacteria,2GRWM@201174|Actinobacteria,4CPJD@84995|Rubrobacteria	84995|Rubrobacteria	M	Belongs to the D-alanine--D-alanine ligase family	-	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
REGS2_k127_817084_1	502558.EGYY_28180	2.857e-171	546.0	COG1167@1|root,COG1167@2|Bacteria,2GITW@201174|Actinobacteria,4CUPT@84998|Coriobacteriia	84998|Coriobacteriia	EK	Alanine-glyoxylate amino-transferase	-	-	-	ko:K05825	ko00300,ko01100,ko01130,ko01210,map00300,map01100,map01130,map01210	-	R01939	RC00006	ko00000,ko00001,ko01000	-	-	-	Aminotran_1_2
REGS2_k127_817084_36	1118060.CAGZ01000030_gene1053	3.743e-09	64.0	2F59P@1|root,33XVV@2|Bacteria,2HUVG@201174|Actinobacteria,4CVSE@84998|Coriobacteriia	84998|Coriobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS2_k127_817084_0	868595.Desca_1359	2.549e-231	747.0	COG1615@1|root,COG1615@2|Bacteria,1TQHM@1239|Firmicutes,248PM@186801|Clostridia,260EY@186807|Peptococcaceae	186801|Clostridia	S	PFAM Uncharacterised protein family UPF0182	-	-	-	ko:K09118	-	-	-	-	ko00000	-	-	-	UPF0182
REGS2_k127_817084_11	243231.GSU0287	4.415e-59	222.0	COG2206@1|root,COG2206@2|Bacteria,1MW7F@1224|Proteobacteria,42PHB@68525|delta/epsilon subdivisions,2WMJX@28221|Deltaproteobacteria,43S0A@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	PFAM metal-dependent phosphohydrolase HD sub domain	-	-	-	-	-	-	-	-	-	-	-	-	HD,HD_5,KOW
REGS2_k127_817084_33	269799.Gmet_2816	3.816e-15	90.0	COG1413@1|root,COG1413@2|Bacteria,1N5TU@1224|Proteobacteria,42UDF@68525|delta/epsilon subdivisions,2WQ3K@28221|Deltaproteobacteria,43TQ4@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
REGS2_k127_817084_28	888743.HMPREF9141_1553	6.341e-27	127.0	COG0424@1|root,COG0424@2|Bacteria,4NNXV@976|Bacteroidetes,2FKYZ@200643|Bacteroidia	976|Bacteroidetes	D	Maf-like protein	maf	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
REGS2_k127_817084_26	1121920.AUAU01000006_gene302	1.778e-32	145.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
REGS2_k127_817084_22	1267535.KB906767_gene347	5.95e-36	153.0	COG2159@1|root,COG2159@2|Bacteria,3Y6P0@57723|Acidobacteria	57723|Acidobacteria	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
REGS2_k127_817084_37	323259.Mhun_2935	4.833e-09	64.0	COG1983@1|root,arCOG03455@2157|Archaea,2Y1D0@28890|Euryarchaeota	28890|Euryarchaeota	K	PFAM PspC domain protein	-	-	-	ko:K03973	-	-	-	-	ko00000,ko02048,ko03000	-	-	-	PspC
REGS2_k127_817084_35	871963.Desdi_0983	1.796e-09	69.0	2DPQR@1|root,3330J@2|Bacteria,1VF83@1239|Firmicutes,25EKT@186801|Clostridia,2645C@186807|Peptococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS2_k127_817084_39	509635.N824_15575	1.215e-05	53.0	COG1983@1|root,COG1983@2|Bacteria,4NRBJ@976|Bacteroidetes,1ITXY@117747|Sphingobacteriia	976|Bacteroidetes	KT	PspC domain	-	-	-	-	-	-	-	-	-	-	-	-	PspC
REGS2_k127_817084_31	857293.CAAU_2054	1.51e-16	82.0	COG1983@1|root,COG1983@2|Bacteria,1VKBQ@1239|Firmicutes,24QU9@186801|Clostridia,36NYT@31979|Clostridiaceae	186801|Clostridia	KT	PspC domain	-	-	-	ko:K03973	-	-	-	-	ko00000,ko02048,ko03000	-	-	-	PspC
REGS2_k127_817084_3	742722.HMPREF9463_00109	1.505e-110	375.0	COG1253@1|root,COG1253@2|Bacteria,2GKN5@201174|Actinobacteria,4CUYP@84998|Coriobacteriia	84998|Coriobacteriia	S	Transporter associated domain	-	-	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
REGS2_k127_817084_23	1125863.JAFN01000001_gene3053	2.085e-35	157.0	COG2206@1|root,COG2206@2|Bacteria,1MW7F@1224|Proteobacteria,42PHB@68525|delta/epsilon subdivisions,2WMJX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	PFAM metal-dependent phosphohydrolase HD sub domain	-	-	-	-	-	-	-	-	-	-	-	-	HD,HD_5,KOW
REGS2_k127_817084_40	1304877.KI519399_gene6076	0.0002481	49.0	COG3682@1|root,COG3682@2|Bacteria,1N6UP@1224|Proteobacteria,2UJ72@28211|Alphaproteobacteria,3K541@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS2_k127_817084_20	1123248.KB893323_gene1604	6.242e-39	155.0	COG1047@1|root,COG1047@2|Bacteria,4NM29@976|Bacteroidetes,1ITWU@117747|Sphingobacteriia	976|Bacteroidetes	O	Peptidyl-prolyl cis-trans isomerase	fkpB	-	5.2.1.8	ko:K01802,ko:K03774,ko:K03775	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C
REGS2_k127_817084_19	1336208.JADY01000006_gene591	9.207e-40	156.0	COG1018@1|root,COG1018@2|Bacteria,1RF85@1224|Proteobacteria,2UBB2@28211|Alphaproteobacteria,2JU9J@204441|Rhodospirillales	204441|Rhodospirillales	C	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS2_k127_817084_2	1173022.Cri9333_3998	1.753e-157	532.0	COG1716@1|root,COG5001@1|root,COG1716@2|Bacteria,COG5001@2|Bacteria,1G0SY@1117|Cyanobacteria,1H7V4@1150|Oscillatoriales	1117|Cyanobacteria	T	signal transduction protein containing a membrane domain an EAL and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,FHA,GAF,GGDEF,PAS_3,PHY
REGS2_k127_817084_16	1304874.JAFY01000002_gene352	6.723e-55	213.0	COG0642@1|root,COG2205@2|Bacteria	1304874.JAFY01000002_gene352|-	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS2_k127_817084_7	868131.MSWAN_1874	1.694e-73	254.0	COG2041@1|root,arCOG00266@2157|Archaea	2157|Archaea	P	COG2041 Sulfite oxidase and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB,Oxidored_molyb
REGS2_k127_817084_12	868131.MSWAN_1258	4.674e-59	214.0	arCOG03165@1|root,arCOG03165@2157|Archaea,2XXAZ@28890|Euryarchaeota,23PM9@183925|Methanobacteria	183925|Methanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS2_k127_817084_9	1304275.C41B8_02517	6.899e-64	228.0	COG1272@1|root,COG1272@2|Bacteria,1PGRH@1224|Proteobacteria,1RR4R@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	hemolysin iii	yqfA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K11068	-	-	-	-	ko00000,ko02042	-	-	-	HlyIII
REGS2_k127_817084_30	186497.PF0283	1.603e-21	97.0	COG1254@1|root,arCOG01674@2157|Archaea,2XYT5@28890|Euryarchaeota,2449Y@183968|Thermococci	183968|Thermococci	C	acylphosphatase activity	acyP	GO:0003674,GO:0003824,GO:0003998,GO:0016787,GO:0016817,GO:0016818	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	-	R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000	-	-	-	Acylphosphatase
REGS2_k127_817084_32	85643.Tmz1t_0731	8.101e-16	91.0	COG0288@1|root,COG0454@1|root,COG0288@2|Bacteria,COG0456@2|Bacteria,1NGFN@1224|Proteobacteria,2VIBS@28216|Betaproteobacteria,2KUSB@206389|Rhodocyclales	206389|Rhodocyclales	P	Reversible hydration of carbon dioxide	-	-	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Acetyltransf_1,Pro_CA
REGS2_k127_817084_6	1121920.AUAU01000008_gene1566	4.821e-77	278.0	COG0697@1|root,COG0697@2|Bacteria,3Y5RD@57723|Acidobacteria	57723|Acidobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
REGS2_k127_817084_8	351160.LRC130	5.635e-66	232.0	COG4912@1|root,arCOG11010@2157|Archaea,2XWKG@28890|Euryarchaeota	28890|Euryarchaeota	L	DNA alkylation repair enzyme	-	-	-	-	-	-	-	-	-	-	-	-	DNA_alkylation
REGS2_k127_817084_21	1304284.L21TH_2400	7.628e-39	162.0	COG0842@1|root,COG0842@2|Bacteria,1V7HN@1239|Firmicutes,25P8R@186801|Clostridia,36J6Y@31979|Clostridiaceae	186801|Clostridia	V	ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
REGS2_k127_817084_18	926569.ANT_08160	4.993e-45	178.0	COG0842@1|root,COG0842@2|Bacteria,2G774@200795|Chloroflexi	200795|Chloroflexi	V	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
REGS2_k127_817084_4	697281.Mahau_1271	8.182e-98	355.0	COG1131@1|root,COG1131@2|Bacteria,1TPMQ@1239|Firmicutes,248QD@186801|Clostridia,42FQ5@68295|Thermoanaerobacterales	186801|Clostridia	V	pfam abc	-	-	-	ko:K01990,ko:K09695	ko02010,map02010	M00252,M00254	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.102	-	-	ABC_tran
REGS2_k127_817084_13	1122925.KB895377_gene1303	2.542e-58	211.0	COG0518@1|root,COG0518@2|Bacteria,1UAH0@1239|Firmicutes,4IS2E@91061|Bacilli,26X7U@186822|Paenibacillaceae	91061|Bacilli	F	Glutamine amidotransferase class-I	-	-	-	-	-	-	-	-	-	-	-	-	GATase
REGS2_k127_817084_24	521003.COLINT_02940	1.018e-34	149.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	ko:K03291	-	-	-	-	ko00000,ko02000	2.A.1.20	-	-	MFS_1
REGS2_k127_8212732_2	1125863.JAFN01000001_gene443	2.77e-205	656.0	COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,42MZJ@68525|delta/epsilon subdivisions,2WJK1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
REGS2_k127_8212732_7	1304284.L21TH_1607	2.058e-102	352.0	COG1249@1|root,COG1249@2|Bacteria,1TP1W@1239|Firmicutes,249R3@186801|Clostridia,36EPX@31979|Clostridiaceae	186801|Clostridia	C	Dihydrolipoyl dehydrogenase	lpdA	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Biotin_lipoyl,Pyr_redox_2,Pyr_redox_dim
REGS2_k127_8212732_8	264732.Moth_1762	1.632e-100	339.0	COG0320@1|root,COG0320@2|Bacteria,1TQM4@1239|Firmicutes,2495Q@186801|Clostridia,42EQR@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	-	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB,LIAS_N,Radical_SAM
REGS2_k127_8212732_15	497321.C664_19361	2.697e-35	150.0	COG2199@1|root,COG3706@2|Bacteria,1MWHH@1224|Proteobacteria,2WGY2@28216|Betaproteobacteria,2KVIH@206389|Rhodocyclales	206389|Rhodocyclales	T	COG2199 FOG GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISMED2,7TMR-DISM_7TM,GGDEF
REGS2_k127_8212732_12	1304880.JAGB01000003_gene1270	1.071e-52	196.0	COG2122@1|root,COG2122@2|Bacteria,1TQ6A@1239|Firmicutes,249KT@186801|Clostridia	186801|Clostridia	S	PFAM ApbE family	-	-	-	ko:K09740	-	-	-	-	ko00000	-	-	-	-
REGS2_k127_8212732_18	326426.Bbr_0280	2.28e-16	85.0	2AFXT@1|root,3161G@2|Bacteria,2IKPZ@201174|Actinobacteria,4D0UV@85004|Bifidobacteriales	201174|Actinobacteria	S	Protein of unknown function (DUF2469)	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF2469
REGS2_k127_8212732_0	1034345.CAEM01000027_gene1003	2.475e-253	799.0	COG0272@1|root,COG0272@2|Bacteria,2GJUY@201174|Actinobacteria,4CURR@84998|Coriobacteriia	84998|Coriobacteriia	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2
REGS2_k127_8212732_10	1416760.AYMS01000012_gene964	5.297e-67	237.0	COG1136@1|root,COG1136@2|Bacteria,4NE5N@976|Bacteroidetes,1HXPP@117743|Flavobacteriia,47HEP@76831|Myroides	976|Bacteroidetes	V	Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides	macB	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
REGS2_k127_8212732_13	292459.STH607	7.228e-52	198.0	COG0577@1|root,COG0577@2|Bacteria,1TUYK@1239|Firmicutes,24DGM@186801|Clostridia	186801|Clostridia	V	ABC-type transport system involved in lipoprotein release permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
REGS2_k127_8212732_25	224719.Abm4_0376	4.347e-07	62.0	COG2221@1|root,arCOG02061@2157|Archaea,2Y7JH@28890|Euryarchaeota,23P37@183925|Methanobacteria	183925|Methanobacteria	C	Nitrite and sulphite reductase 4Fe-4S domain	-	-	1.8.98.3	ko:K21816	-	-	-	-	ko00000,ko01000	-	-	-	Fer4,FrhB_FdhB_C,FrhB_FdhB_N,NIR_SIR,NIR_SIR_ferr
REGS2_k127_8212732_21	166314.Syncc8109_0772	1.516e-09	70.0	COG1266@1|root,COG1266@2|Bacteria,1G0ZJ@1117|Cyanobacteria,1GZ8P@1129|Synechococcus	1117|Cyanobacteria	S	metal-dependent membrane protease	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
REGS2_k127_8212732_17	1123284.KB899058_gene899	9.015e-22	100.0	COG0721@1|root,COG0721@2|Bacteria,1VEK3@1239|Firmicutes,4HNNA@91061|Bacilli,26P3B@186821|Sporolactobacillaceae	91061|Bacilli	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	-	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Glu-tRNAGln
REGS2_k127_8212732_4	760568.Desku_1682	2.02e-172	554.0	COG0154@1|root,COG0154@2|Bacteria,1TP0C@1239|Firmicutes,24911@186801|Clostridia,2613E@186807|Peptococcaceae	186801|Clostridia	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
REGS2_k127_8212732_22	1499967.BAYZ01000152_gene1383	2.054e-09	70.0	COG3437@1|root,COG5002@1|root,COG3437@2|Bacteria,COG5002@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	-	-	2.7.13.3	ko:K07814,ko:K11527	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
REGS2_k127_8212732_6	697284.ERIC2_c31060	1.403e-155	506.0	COG0064@1|root,COG0064@2|Bacteria,1TPG3@1239|Firmicutes,4HAFB@91061|Bacilli,26R27@186822|Paenibacillaceae	91061|Bacilli	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
REGS2_k127_8212732_26	324057.Pjdr2_5732	1.841e-05	57.0	COG4942@1|root,COG4942@2|Bacteria,1TQ5I@1239|Firmicutes,4HB9Q@91061|Bacilli,26SER@186822|Paenibacillaceae	91061|Bacilli	D	membrane	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
REGS2_k127_8212732_19	1348338.ADILRU_1125	2.577e-15	88.0	COG0791@1|root,COG2247@1|root,COG0791@2|Bacteria,COG2247@2|Bacteria,2IK12@201174|Actinobacteria	201174|Actinobacteria	M	cell wall binding repeat	-	-	-	-	-	-	-	-	-	-	-	-	CW_binding_2
REGS2_k127_8212732_20	573370.DMR_09150	4.168e-12	74.0	2AJGP@1|root,31A33@2|Bacteria,1Q4TY@1224|Proteobacteria,43281@68525|delta/epsilon subdivisions,2WX8N@28221|Deltaproteobacteria,2MFVF@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS2_k127_8212732_23	751944.HALDL1_13390	4.329e-09	68.0	arCOG02387@1|root,arCOG02387@2157|Archaea,2Y149@28890|Euryarchaeota,240V2@183963|Halobacteria	183963|Halobacteria	T	COG0784 FOG CheY-like receiver	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_4,PAS_9,Response_reg
REGS2_k127_8212732_9	864073.HFRIS_022163	2.304e-72	253.0	COG1273@1|root,COG1273@2|Bacteria,1N4UX@1224|Proteobacteria,2VJE3@28216|Betaproteobacteria,472N1@75682|Oxalobacteraceae	28216|Betaproteobacteria	L	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD	ku	-	-	ko:K10979	ko03450,map03450	-	-	-	ko00000,ko00001,ko03400	-	-	-	Ku
REGS2_k127_8212732_1	690850.Desaf_0308	8.349e-227	734.0	COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria,1MVWY@1224|Proteobacteria,4378Z@68525|delta/epsilon subdivisions,2X2C2@28221|Deltaproteobacteria,2MEZH@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	DNA ligase	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	-
REGS2_k127_8212732_24	379731.PST_1502	4.02e-07	62.0	COG0392@1|root,COG0392@2|Bacteria,1R959@1224|Proteobacteria,1S56U@1236|Gammaproteobacteria,1Z1XF@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	S	Integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	LPG_synthase_TM
REGS2_k127_8212732_5	935948.KE386495_gene2056	1.194e-164	527.0	COG0119@1|root,COG0119@2|Bacteria,1TP4Y@1239|Firmicutes,2495J@186801|Clostridia,42F5P@68295|Thermoanaerobacterales	186801|Clostridia	H	PFAM Pyruvate carboxyltransferase	nifV	-	2.3.3.14	ko:K02594	ko00620,map00620	-	R00271	RC00004,RC00067,RC02754	ko00000,ko00001,ko01000	-	-	-	HMGL-like
REGS2_k127_8212732_3	1121472.AQWN01000002_gene2286	2.292e-181	581.0	COG0065@1|root,COG0065@2|Bacteria,1TPE5@1239|Firmicutes,2484F@186801|Clostridia,260UR@186807|Peptococcaceae	186801|Clostridia	H	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	-	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
REGS2_k127_8212732_11	429009.Adeg_1101	4.862e-62	236.0	COG0066@1|root,COG0066@2|Bacteria,1V1I6@1239|Firmicutes,24F1M@186801|Clostridia,42JF3@68295|Thermoanaerobacterales	186801|Clostridia	E	Aconitase C-terminal domain	-	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
REGS2_k127_8212732_16	1111121.HMPREF1247_0208	4.648e-26	108.0	COG1278@1|root,COG1278@2|Bacteria,2GQRU@201174|Actinobacteria,4CWDJ@84998|Coriobacteriia	84998|Coriobacteriia	K	'Cold-shock' DNA-binding domain	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
REGS2_k127_8212732_14	632518.Calow_0380	1.594e-45	170.0	COG0473@1|root,COG0473@2|Bacteria,1TPEM@1239|Firmicutes,24A63@186801|Clostridia,42EVK@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM isocitrate isopropylmalate dehydrogenase	icd	-	1.1.1.41	ko:K00030	ko00020,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010	R00709	RC00114	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
REGS2_k127_8218754_7	243231.GSU1515	1.857e-57	207.0	COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,42M20@68525|delta/epsilon subdivisions,2WJ2N@28221|Deltaproteobacteria,43SZ5@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
REGS2_k127_8218754_10	42256.RradSPS_1542	2.728e-38	149.0	COG1933@1|root,COG1933@2|Bacteria,2GU4W@201174|Actinobacteria,4CQ2Q@84995|Rubrobacteria	84995|Rubrobacteria	L	Double zinc ribbon	-	-	-	-	-	-	-	-	-	-	-	-	DZR
REGS2_k127_8218754_5	365528.KB891102_gene4587	1.122e-72	262.0	COG0285@1|root,COG0285@2|Bacteria,2GJP2@201174|Actinobacteria,4ERQF@85013|Frankiales	201174|Actinobacteria	H	Mur ligase, middle domain protein	folC	GO:0003674,GO:0003824,GO:0004326,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006761,GO:0006807,GO:0008150,GO:0008152,GO:0008841,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046452,GO:0046483,GO:0046900,GO:0046901,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2447c	Mur_ligase_C,Mur_ligase_M
REGS2_k127_8218754_0	502558.EGYY_18720	0.0	1058.0	COG0525@1|root,COG0525@2|Bacteria,2GK8H@201174|Actinobacteria,4CUW2@84998|Coriobacteriia	84998|Coriobacteriia	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
REGS2_k127_8218754_1	2045.KR76_20210	6.429e-179	570.0	COG1219@1|root,COG1219@2|Bacteria,2GJXQ@201174|Actinobacteria,4DP0T@85009|Propionibacteriales	201174|Actinobacteria	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	-	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
REGS2_k127_8218754_4	1158318.ATXC01000001_gene1441	2.959e-81	274.0	COG0740@1|root,COG0740@2|Bacteria,2G3IM@200783|Aquificae	200783|Aquificae	O	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
REGS2_k127_8218754_6	1121428.DESHY_120025___1	3.057e-72	265.0	COG0544@1|root,COG0544@2|Bacteria,1TQQ8@1239|Firmicutes,248C3@186801|Clostridia,260PB@186807|Peptococcaceae	186801|Clostridia	D	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
REGS2_k127_8218754_12	1121355.KB903379_gene745	4.278e-05	53.0	COG0544@1|root,COG0544@2|Bacteria,2GJIG@201174|Actinobacteria,22JV9@1653|Corynebacteriaceae	201174|Actinobacteria	D	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042221,GO:0042594,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0071496,GO:0071944	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
REGS2_k127_8218754_8	742818.HMPREF9451_01074	2.362e-54	199.0	COG0127@1|root,COG0127@2|Bacteria,2GM2B@201174|Actinobacteria,4CUUU@84998|Coriobacteriia	84998|Coriobacteriia	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	rdgB	-	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
REGS2_k127_8218754_3	521003.COLINT_02905	8.039e-90	302.0	COG0689@1|root,COG0689@2|Bacteria,2GJFI@201174|Actinobacteria,4CU90@84998|Coriobacteriia	84998|Coriobacteriia	J	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates	rph	-	2.7.7.56	ko:K00989	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNase_PH,RNase_PH_C
REGS2_k127_8218754_9	1907.SGLAU_08480	1.488e-39	166.0	COG1234@1|root,COG1234@2|Bacteria,2GMEX@201174|Actinobacteria	201174|Actinobacteria	S	Metal-dependent hydrolases of the beta-lactamase superfamily III	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
REGS2_k127_8218754_2	742818.HMPREF9451_01076	5.798e-101	338.0	COG0796@1|root,COG0796@2|Bacteria,2GN4I@201174|Actinobacteria,4CVD5@84998|Coriobacteriia	84998|Coriobacteriia	M	Provides the (R)-glutamate required for cell wall biosynthesis	murI	-	5.1.1.3	ko:K01776	ko00471,ko01100,map00471,map01100	-	R00260	RC00302	ko00000,ko00001,ko01000,ko01011	-	-	-	Asp_Glu_race
REGS2_k127_8301334_1	709797.CSIRO_2957	4.849e-148	485.0	COG0366@1|root,COG0366@2|Bacteria,1MVKX@1224|Proteobacteria,2TRS3@28211|Alphaproteobacteria,3JS80@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Alpha-amylase domain	MA20_23410	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	Alpha-amylase,DUF3459
REGS2_k127_8301334_6	1304874.JAFY01000002_gene352	3.338e-46	188.0	COG0642@1|root,COG2205@2|Bacteria	1304874.JAFY01000002_gene352|-	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS2_k127_8301334_2	398767.Glov_0559	5.887e-70	256.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2WIR4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_4,PAS_9,Response_reg,SBP_bac_3
REGS2_k127_8301334_4	1504822.CCNO01000008_gene2012	1.015e-59	213.0	COG0590@1|root,COG0590@2|Bacteria,2NPM7@2323|unclassified Bacteria	2|Bacteria	FJ	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)	tadA	-	3.5.4.1,3.5.4.33,3.8.1.5,6.3.4.19	ko:K01485,ko:K01563,ko:K04075,ko:K11991	ko00240,ko00330,ko00361,ko00625,ko01100,ko01120,map00240,map00330,map00361,map00625,map01100,map01120	-	R00974,R01411,R02922,R05284,R05367,R05368,R05369,R05370,R07669,R07670,R09597,R10223	RC00074,RC00477,RC00514,RC00809,RC01317,RC01340,RC01341,RC02013,RC02633,RC02634	ko00000,ko00001,ko01000,ko03016	-	-	-	MafB19-deam,dCMP_cyt_deam_1
REGS2_k127_8301334_8	1121861.KB899917_gene3618	1.865e-20	98.0	2BQVQ@1|root,32JSN@2|Bacteria,1RJK4@1224|Proteobacteria,2UAA6@28211|Alphaproteobacteria,2JXH7@204441|Rhodospirillales	204441|Rhodospirillales	S	L-2-amino-thiazoline-4-carboxylic acid hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	ATC_hydrolase
REGS2_k127_8301334_7	1206731.BAGB01000037_gene9203	3.322e-35	136.0	COG0025@1|root,COG0025@2|Bacteria,2GIUT@201174|Actinobacteria,4FWFN@85025|Nocardiaceae	201174|Actinobacteria	P	Sodium/hydrogen exchanger family	-	-	-	ko:K03316	-	-	-	-	ko00000	2.A.36	-	-	Na_H_Exchanger,zf-UBP
REGS2_k127_8301334_5	318464.IO99_08780	6.524e-57	206.0	2C91C@1|root,30CC5@2|Bacteria,1V1Z2@1239|Firmicutes,24HJH@186801|Clostridia,36IUN@31979|Clostridiaceae	186801|Clostridia	S	Putative redox-active protein (C_GCAxxG_C_C)	-	-	-	-	-	-	-	-	-	-	-	-	C_GCAxxG_C_C
REGS2_k127_8301334_3	865861.AZSU01000002_gene2648	1.233e-68	243.0	COG1275@1|root,COG1275@2|Bacteria,1UYTE@1239|Firmicutes,2497H@186801|Clostridia,36FBE@31979|Clostridiaceae	186801|Clostridia	P	Voltage-dependent anion channel	-	-	-	ko:K11041	ko05150,map05150	-	-	-	ko00000,ko00001,ko02042	2.A.16	-	-	SLAC1
REGS2_k127_8301334_0	292459.STH2051	1.674e-196	634.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia	186801|Clostridia	C	Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
REGS2_k127_8301334_9	349521.HCH_05054	2.674e-09	60.0	COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,1RMVU@1236|Gammaproteobacteria,1XIS5@135619|Oceanospirillales	135619|Oceanospirillales	C	alcohol dehydrogenase	-	-	1.1.1.1	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
REGS2_k127_8341268_0	555088.DealDRAFT_1867	8.617e-264	834.0	COG0046@1|root,COG0046@2|Bacteria,1TPAS@1239|Firmicutes,247W2@186801|Clostridia,42KE4@68298|Syntrophomonadaceae	186801|Clostridia	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C,GATase_5
REGS2_k127_8341268_2	697281.Mahau_1635	7.693e-85	288.0	COG0047@1|root,COG0047@2|Bacteria,1TP1B@1239|Firmicutes,24A2E@186801|Clostridia,42EVD@68295|Thermoanaerobacterales	186801|Clostridia	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purQ	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
REGS2_k127_8341268_3	981383.AEWH01000051_gene432	2.154e-22	98.0	COG1828@1|root,COG1828@2|Bacteria,1VEH1@1239|Firmicutes,4HP0E@91061|Bacilli	91061|Bacilli	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purS	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	iYO844.BSU06460	PurS
REGS2_k127_8341268_5	502558.EGYY_03900	2.903e-07	60.0	2BMDB@1|root,32FXR@2|Bacteria,2HTNR@201174|Actinobacteria,4CW54@84998|Coriobacteriia	84998|Coriobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS2_k127_8341268_1	530564.Psta_4309	4.91e-90	300.0	COG0152@1|root,COG0152@2|Bacteria,2IY7D@203682|Planctomycetes	203682|Planctomycetes	F	SAICAR synthetase	purC	GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
REGS2_k127_8366888_1	1118060.CAGZ01000024_gene521	1.791e-157	515.0	COG0568@1|root,COG0568@2|Bacteria,2GK3Z@201174|Actinobacteria,4CV1T@84998|Coriobacteriia	84998|Coriobacteriia	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	sigA	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
REGS2_k127_8366888_2	1235794.C811_00687	9.735e-145	480.0	COG0358@1|root,COG0358@2|Bacteria,2GJFX@201174|Actinobacteria,4CUGG@84998|Coriobacteriia	84998|Coriobacteriia	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
REGS2_k127_8366888_0	373903.Hore_15760	9.441e-215	688.0	COG3808@1|root,COG3808@2|Bacteria,1TNZI@1239|Firmicutes,248KS@186801|Clostridia,3WA8T@53433|Halanaerobiales	186801|Clostridia	C	Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na( ) movement across the membrane	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
REGS2_k127_8366888_5	1125863.JAFN01000001_gene3475	1.128e-13	76.0	COG1569@1|root,COG1569@2|Bacteria,1Q9X7@1224|Proteobacteria,42X9V@68525|delta/epsilon subdivisions,2WT2V@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN_3
REGS2_k127_8366888_3	1235794.C811_01239	4.114e-115	400.0	COG0232@1|root,COG0232@2|Bacteria,2GJ8F@201174|Actinobacteria,4CVBJ@84998|Coriobacteriia	84998|Coriobacteriia	F	Belongs to the dGTPase family. Type 2 subfamily	-	-	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	-	HD,HD_assoc
REGS2_k127_8366888_6	176299.Atu3009	8.604e-06	57.0	COG1835@1|root,COG1835@2|Bacteria,1RICE@1224|Proteobacteria,2U9YK@28211|Alphaproteobacteria,4B82V@82115|Rhizobiaceae	28211|Alphaproteobacteria	I	Exopolysaccharide production protein	exoZ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K16568	-	-	-	-	ko00000	-	-	-	Acyl_transf_3,Glyco_hydro_16
REGS2_k127_8366888_4	742818.HMPREF9451_00619	2.07e-96	320.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2GK73@201174|Actinobacteria,4CUB1@84998|Coriobacteriia	84998|Coriobacteriia	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
REGS2_k127_8465050_0	742818.HMPREF9451_00220	3.14e-264	835.0	COG0550@1|root,COG0551@1|root,COG0550@2|Bacteria,COG0551@2|Bacteria,2GJU7@201174|Actinobacteria,4CU99@84998|Coriobacteriia	84998|Coriobacteriia	L	DNA topoisomerase	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,zf-C4_Topoisom
REGS2_k127_8465050_2	479437.Elen_1140	3.529e-105	353.0	COG0039@1|root,COG0039@2|Bacteria,2GN5S@201174|Actinobacteria,4CVAY@84998|Coriobacteriia	84998|Coriobacteriia	C	Belongs to the LDH MDH superfamily	-	-	1.1.1.27,1.1.1.37	ko:K00016,ko:K00024	ko00010,ko00020,ko00270,ko00620,ko00630,ko00640,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04922,map00010,map00020,map00270,map00620,map00630,map00640,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200,map04922	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R00703,R01000,R03104,R07136	RC00031,RC00044	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Ldh_1_C,Ldh_1_N
REGS2_k127_8465050_3	1034345.CAEM01000023_gene867	1.264e-95	327.0	COG1951@1|root,COG1951@2|Bacteria,2I7Z2@201174|Actinobacteria,4CUKE@84998|Coriobacteriia	84998|Coriobacteriia	C	Fumarate hydratase (Fumerase)	-	-	4.2.1.2	ko:K01677	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase
REGS2_k127_8465050_11	1123023.JIAI01000017_gene3558	8.514e-31	140.0	COG0125@1|root,COG0477@1|root,COG0125@2|Bacteria,COG0477@2|Bacteria,2GNTI@201174|Actinobacteria,4DYRV@85010|Pseudonocardiales	201174|Actinobacteria	EFGP	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	MFS_3,Thymidylate_kin
REGS2_k127_8465050_8	1034345.CAEM01000023_gene868	1.7e-56	204.0	COG1838@1|root,COG1838@2|Bacteria,2GK6D@201174|Actinobacteria,4CVP8@84998|Coriobacteriia	84998|Coriobacteriia	C	Fumarase C-terminus	-	-	4.2.1.2	ko:K01678	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase_C
REGS2_k127_8465050_9	443143.GM18_3246	5.914e-56	209.0	COG0125@1|root,COG0125@2|Bacteria,1MV9C@1224|Proteobacteria,42RK3@68525|delta/epsilon subdivisions,2WNES@28221|Deltaproteobacteria,43U3M@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
REGS2_k127_8465050_5	502558.EGYY_10890	4.74e-85	301.0	COG2812@1|root,COG2812@2|Bacteria,2I5XV@201174|Actinobacteria,4CU9U@84998|Coriobacteriia	84998|Coriobacteriia	L	DNA polymerase III	-	-	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNApol3-delta_C
REGS2_k127_8465050_4	1232436.CAPF01000046_gene563	2.774e-86	301.0	COG1774@1|root,COG1774@2|Bacteria,2HYDT@201174|Actinobacteria,4CUHD@84998|Coriobacteriia	84998|Coriobacteriia	S	PSP1 C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	PSP1
REGS2_k127_8465050_6	742818.HMPREF9451_01268	2.317e-73	262.0	COG0265@1|root,COG0265@2|Bacteria,2GJ96@201174|Actinobacteria,4CV2A@84998|Coriobacteriia	84998|Coriobacteriia	O	PDZ DHR GLGF domain protein	-	-	-	ko:K08372	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Trypsin_2
REGS2_k127_8465050_10	445975.COLSTE_00548	7.299e-46	172.0	COG1576@1|root,COG1576@2|Bacteria,2IJE0@201174|Actinobacteria,4CVNM@84998|Coriobacteriia	84998|Coriobacteriia	J	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA	rlmH	-	2.1.1.177	ko:K00783	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SPOUT_MTase
REGS2_k127_8465050_12	1232436.CAPF01000053_gene128	4.203e-07	62.0	29Y8J@1|root,30K2A@2|Bacteria,2HVZH@201174|Actinobacteria,4CXSM@84998|Coriobacteriia	84998|Coriobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS2_k127_8465050_1	1122919.KB905560_gene1479	8.861e-113	373.0	COG2084@1|root,COG2084@2|Bacteria,1TR4F@1239|Firmicutes,4H9MA@91061|Bacilli,26QSG@186822|Paenibacillaceae	91061|Bacilli	I	3-hydroxyisobutyrate dehydrogenase	glxR	-	1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
REGS2_k127_8465050_7	1403819.BATR01000038_gene1148	2.792e-72	259.0	2DR4U@1|root,33A62@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	CreD
REGS2_k127_8513253_15	638303.Thal_1119	0.0004353	44.0	COG1811@1|root,COG1811@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF554)	ydfK	-	-	ko:K07150	-	-	-	-	ko00000	-	-	-	DUF554
REGS2_k127_8513253_13	525904.Tter_1473	9.586e-07	58.0	COG3688@1|root,COG3688@2|Bacteria	2|Bacteria	D	RNA-binding protein containing a PIN domain	yacP	-	-	ko:K06962	-	-	-	-	ko00000	-	-	-	EFG_C,EFG_IV,GTP_EFTU,NYN_YacP
REGS2_k127_8513253_5	760192.Halhy_5709	3.655e-91	307.0	COG0330@1|root,COG0330@2|Bacteria,4NFPK@976|Bacteroidetes,1IRDU@117747|Sphingobacteriia	976|Bacteroidetes	O	PFAM SPFH domain Band 7 family	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
REGS2_k127_8513253_12	191610.CATYP_08425	1.373e-07	56.0	COG1225@1|root,COG1225@2|Bacteria,2IHZ6@201174|Actinobacteria,22MX4@1653|Corynebacteriaceae	201174|Actinobacteria	O	bacterioferritin comigratory protein	bcp	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
REGS2_k127_8513253_10	273121.WS0196	5.94e-21	95.0	COG1225@1|root,COG1225@2|Bacteria,1RD4R@1224|Proteobacteria,42RHG@68525|delta/epsilon subdivisions,2YNVV@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	O	bacterioferritin comigratory protein	bcp	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
REGS2_k127_8513253_11	1041930.Mtc_2217	5.62e-16	84.0	COG3794@1|root,arCOG02929@2157|Archaea,2Y1NH@28890|Euryarchaeota,2NB8Y@224756|Methanomicrobia	224756|Methanomicrobia	C	Cupredoxin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1
REGS2_k127_8513253_1	1382356.JQMP01000004_gene505	2.813e-114	391.0	COG1331@1|root,COG1331@2|Bacteria,2G5R1@200795|Chloroflexi,27XU1@189775|Thermomicrobia	189775|Thermomicrobia	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	Thioredox_DsbH
REGS2_k127_8513253_3	794903.OPIT5_02835	1.352e-99	353.0	COG0513@1|root,COG0513@2|Bacteria,46TUA@74201|Verrucomicrobia,3K7AP@414999|Opitutae	414999|Opitutae	L	DEAD DEAH box helicase	-	-	-	-	-	-	-	-	-	-	-	-	DEAD,Helicase_C
REGS2_k127_8513253_2	351607.Acel_0686	1.408e-104	350.0	COG2008@1|root,COG2008@2|Bacteria,2GJ0V@201174|Actinobacteria	201174|Actinobacteria	E	Threonine aldolase	ltaE	-	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	-	R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
REGS2_k127_8513253_14	383372.Rcas_2595	5.936e-05	47.0	COG4420@1|root,COG4420@2|Bacteria,2GAPG@200795|Chloroflexi,376QD@32061|Chloroflexia	32061|Chloroflexia	S	Protein of unknown function (DUF1003)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1003
REGS2_k127_8513253_8	68194.JNXR01000004_gene4340	3.497e-37	160.0	COG0586@1|root,COG0586@2|Bacteria,2GKKC@201174|Actinobacteria	201174|Actinobacteria	I	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
REGS2_k127_8513253_7	56780.SYN_02059	3.215e-70	250.0	COG2006@1|root,COG2006@2|Bacteria,1QMGX@1224|Proteobacteria,42PRJ@68525|delta/epsilon subdivisions,2WMFN@28221|Deltaproteobacteria,2MQHV@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
REGS2_k127_8513253_6	1499967.BAYZ01000088_gene5058	5.839e-84	302.0	COG0348@1|root,COG1143@1|root,COG1148@1|root,COG0348@2|Bacteria,COG1143@2|Bacteria,COG1148@2|Bacteria,2NP1X@2323|unclassified Bacteria	2|Bacteria	C	4Fe-4S binding domain	napF	-	-	ko:K02572	-	-	-	-	ko00000	-	-	-	Fer4,Fer4_4,Fer4_5,Fer4_6,Fer4_7
REGS2_k127_8513253_9	635013.TherJR_0120	9.727e-36	152.0	COG0484@1|root,COG0484@2|Bacteria	2|Bacteria	O	heat shock protein binding	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_c3_2,Cytochrome_C554,Cytochrome_C7,Paired_CXXCH_1
REGS2_k127_8513253_0	484770.UFO1_1183	5.55e-153	512.0	COG0577@1|root,COG0577@2|Bacteria,1U388@1239|Firmicutes,4H32X@909932|Negativicutes	909932|Negativicutes	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
REGS2_k127_8513253_4	357808.RoseRS_3212	2.119e-92	311.0	COG0664@1|root,COG1136@1|root,COG0664@2|Bacteria,COG1136@2|Bacteria,2G6C9@200795|Chloroflexi,37685@32061|Chloroflexia	32061|Chloroflexia	V	ABC transporter related	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,cNMP_binding
REGS2_k127_8529421_2	1267533.KB906733_gene2966	9.463e-69	247.0	COG0005@1|root,COG0005@2|Bacteria,3Y2MB@57723|Acidobacteria,2JHYE@204432|Acidobacteriia	204432|Acidobacteriia	F	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate	-	-	2.4.2.1	ko:K03783	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244	RC00033,RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
REGS2_k127_8529421_0	926569.ANT_16170	1.23e-188	599.0	COG0499@1|root,COG0499@2|Bacteria,2G5X8@200795|Chloroflexi	200795|Chloroflexi	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
REGS2_k127_8529421_4	1267533.KB906733_gene3137	9.134e-10	73.0	COG2273@1|root,COG3292@1|root,COG4733@1|root,COG4993@1|root,COG2273@2|Bacteria,COG3292@2|Bacteria,COG4733@2|Bacteria,COG4993@2|Bacteria,3Y2WV@57723|Acidobacteria	57723|Acidobacteria	G	cellulase activity	-	-	-	-	-	-	-	-	-	-	-	-	CHB_HEX_C_1,Lectin_legB
REGS2_k127_8529421_1	756067.MicvaDRAFT_3420	4.281e-79	298.0	COG0823@1|root,COG2931@1|root,COG0823@2|Bacteria,COG2931@2|Bacteria,1G554@1117|Cyanobacteria,1HF7I@1150|Oscillatoriales	1117|Cyanobacteria	QU	PFAM Haemolysin-type calcium-binding repeat	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind,PD40
REGS2_k127_8529421_3	4792.ETI43964	5.639e-22	113.0	KOG0613@1|root,KOG1789@1|root,KOG0613@2759|Eukaryota,KOG1789@2759|Eukaryota,3QCD8@4776|Peronosporales	4776|Peronosporales	O	regulation of early endosome to recycling endosome transport	-	-	-	-	-	-	-	-	-	-	-	-	-
## 1588 queries scanned
## Total time (seconds): 176.94190621376038
## Rate: 8.97 q/s