## Wed Nov 13 10:52:40 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/4635/R/REGS3_bin.24.fa -m mmseqs --itype genome -o REGS3_bin.24 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/bins_4635/REGS3_bin.24 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
REGS3_k127_1011357_2	1217713.F993_02372	4.76e-12	72.0	29RPH@1|root,30CSW@2|Bacteria,1RBS4@1224|Proteobacteria,1SMQF@1236|Gammaproteobacteria,3NR4Y@468|Moraxellaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_1011357_1	66373.JOFQ01000005_gene3646	3.553e-121	396.0	COG2141@1|root,COG2141@2|Bacteria,2GMUP@201174|Actinobacteria	201174|Actinobacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
REGS3_k127_1011357_0	1283287.KB822578_gene2606	3.865e-141	456.0	COG2141@1|root,COG2141@2|Bacteria,2GIY3@201174|Actinobacteria,4DNMR@85009|Propionibacteriales	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
REGS3_k127_1011357_3	65497.JODV01000002_gene4167	6.066e-07	51.0	COG0500@1|root,COG2226@2|Bacteria,2IBY2@201174|Actinobacteria,4EB3X@85010|Pseudonocardiales	201174|Actinobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
REGS3_k127_101445_1	1313172.YM304_15550	6.91e-142	456.0	COG1028@1|root,COG1028@2|Bacteria,2GJ1F@201174|Actinobacteria,4CMRY@84992|Acidimicrobiia	201174|Actinobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
REGS3_k127_101445_3	1370120.AUWR01000020_gene2866	3.237e-18	93.0	COG0644@1|root,COG0644@2|Bacteria,2GUA3@201174|Actinobacteria,237IZ@1762|Mycobacteriaceae	201174|Actinobacteria	C	Mycothiol maleylpyruvate isomerase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_N
REGS3_k127_101445_0	1313172.YM304_15600	1.501e-229	721.0	COG0318@1|root,COG0318@2|Bacteria,2GJA2@201174|Actinobacteria	201174|Actinobacteria	IQ	synthetase	-	-	6.2.1.42	ko:K18688	-	-	-	-	ko00000,ko01000	-	-	-	AMP-binding,AMP-binding_C
REGS3_k127_101445_2	1313172.YM304_28200	2.215e-61	214.0	COG0624@1|root,COG0624@2|Bacteria,2GKKW@201174|Actinobacteria,4CP4J@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
REGS3_k127_1014872_0	1313172.YM304_29840	0.0	1413.0	COG2609@1|root,COG2609@2|Bacteria,2GJRE@201174|Actinobacteria,4CMQ1@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	aceE	-	1.2.4.1	ko:K00163	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
REGS3_k127_1014872_1	1313172.YM304_07910	1.666e-59	230.0	COG3291@1|root,COG3291@2|Bacteria,2I7X8@201174|Actinobacteria,4CP5K@84992|Acidimicrobiia	2|Bacteria	S	Pkd domain containing protein	-	-	3.1.3.5,3.2.1.14	ko:K01081,ko:K01183,ko:K20276	ko00230,ko00240,ko00520,ko00760,ko01100,ko01110,ko02024,map00230,map00240,map00520,map00760,map01100,map01110,map02024	-	R00183,R00511,R00963,R01126,R01206,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02334,R02719,R03346	RC00017,RC00467	ko00000,ko00001,ko01000	-	GH18	-	F5_F8_type_C,Melibiase_2,NPCBM_assoc,PKD,PPC,Trypsin_2,VPEP
REGS3_k127_1014872_5	179408.Osc7112_4230	9.601e-37	159.0	COG2340@1|root,COG2931@1|root,COG2340@2|Bacteria,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	3.4.17.14	ko:K07260	ko00550,ko01100,ko01502,ko02020,map00550,map01100,map01502,map02020	M00651	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504	-	-	-	CAP,HemolysinCabind,LGFP,VanY
REGS3_k127_1014872_2	1150399.AQYK01000002_gene2736	6.53e-56	201.0	COG2227@1|root,COG2227@2|Bacteria,2ID2Z@201174|Actinobacteria	201174|Actinobacteria	H	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25
REGS3_k127_1014872_4	425104.Ssed_2991	1.872e-49	189.0	COG0463@1|root,COG0463@2|Bacteria,1QFUD@1224|Proteobacteria,1TD4S@1236|Gammaproteobacteria,2QDXE@267890|Shewanellaceae	1236|Gammaproteobacteria	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
REGS3_k127_1014872_3	1122939.ATUD01000006_gene1707	2.249e-55	202.0	COG0463@1|root,COG0463@2|Bacteria,2GM44@201174|Actinobacteria	201174|Actinobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
REGS3_k127_1014872_7	219305.MCAG_04684	5.467e-11	73.0	COG0110@1|root,COG0110@2|Bacteria,2H5M0@201174|Actinobacteria,4DD8D@85008|Micromonosporales	201174|Actinobacteria	S	Hexapeptide repeat of succinyl-transferase	-	-	-	-	-	-	-	-	-	-	-	-	FdtA,Hexapep,Hexapep_2
REGS3_k127_1024834_4	1313172.YM304_33350	6.295e-28	117.0	COG1523@1|root,COG1523@2|Bacteria,2GJ00@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase 13 family	glgX	-	3.2.1.196,3.2.1.68	ko:K01214,ko:K02438	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02111,R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
REGS3_k127_1024834_1	47716.JOFH01000005_gene1425	2.35e-126	418.0	COG0141@1|root,COG0141@2|Bacteria,2GNCN@201174|Actinobacteria	201174|Actinobacteria	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	-	-	1.1.1.308	ko:K15509	-	-	-	-	ko00000,ko01000	-	-	-	Histidinol_dh
REGS3_k127_1024834_0	1907.SGLAU_24410	1.55e-181	579.0	COG0665@1|root,COG0665@2|Bacteria,2GJQ9@201174|Actinobacteria	201174|Actinobacteria	E	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
REGS3_k127_1024834_2	471852.Tcur_3385	3.988e-91	308.0	COG1028@1|root,COG1028@2|Bacteria,2GMEH@201174|Actinobacteria,4EMUX@85012|Streptosporangiales	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
REGS3_k127_1024834_5	246196.MSMEI_1964	3.152e-12	71.0	2ETCD@1|root,33KW9@2|Bacteria,2GWP0@201174|Actinobacteria	201174|Actinobacteria	S	Stress responsive A/B Barrel Domain	-	-	-	-	-	-	-	-	-	-	-	-	Dabb
REGS3_k127_1024834_3	309801.trd_A0257	5.41e-35	151.0	COG5401@1|root,COG5401@2|Bacteria,2GA61@200795|Chloroflexi,27Y9M@189775|Thermomicrobia	189775|Thermomicrobia	S	Sporulation and spore germination	-	-	-	-	-	-	-	-	-	-	-	-	Germane,Gmad2
REGS3_k127_1026776_22	1157640.AQWO01000011_gene3288	1.749e-07	55.0	COG0637@1|root,COG0637@2|Bacteria,2I7TC@201174|Actinobacteria	201174|Actinobacteria	H	Haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
REGS3_k127_1026776_1	1313172.YM304_37800	4.289e-141	455.0	COG0113@1|root,COG0113@2|Bacteria,2GJJ0@201174|Actinobacteria,4CMV9@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Delta-aminolevulinic acid dehydratase	hemB	-	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
REGS3_k127_1026776_0	1313172.YM304_37790	8.07e-203	645.0	COG0001@1|root,COG0001@2|Bacteria,2GJSH@201174|Actinobacteria,4CMTZ@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Aminotransferase class-III	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
REGS3_k127_1026776_6	1313172.YM304_37770	1.066e-89	308.0	COG3380@1|root,COG3380@2|Bacteria,2IA89@201174|Actinobacteria	201174|Actinobacteria	S	NAD FAD-dependent oxidoreductase	-	-	-	ko:K06955	-	-	-	-	ko00000	-	-	-	Amino_oxidase,NAD_binding_8
REGS3_k127_1026776_4	1313172.YM304_37760	1.603e-117	383.0	COG2021@1|root,COG2021@2|Bacteria	2|Bacteria	E	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine	-	-	3.1.1.24	ko:K01055	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00568	R02991	RC00825	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1
REGS3_k127_1026776_2	1313172.YM304_37740	1.611e-121	400.0	COG0451@1|root,COG0451@2|Bacteria	2|Bacteria	GM	ADP-glyceromanno-heptose 6-epimerase activity	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
REGS3_k127_1026776_15	1313172.YM304_25800	4.456e-39	167.0	COG0739@1|root,COG3409@1|root,COG0739@2|Bacteria,COG3409@2|Bacteria,2IDIJ@201174|Actinobacteria	201174|Actinobacteria	M	Peptidoglycan-binding domain 1 protein	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1
REGS3_k127_1026776_3	1313172.YM304_37700	2.053e-120	392.0	COG4894@1|root,COG4894@2|Bacteria,2GMU8@201174|Actinobacteria	201174|Actinobacteria	S	Scramblase	-	-	-	-	-	-	-	-	-	-	-	-	DUF2510,Scramblase
REGS3_k127_1026776_9	1313172.YM304_37690	1.982e-82	277.0	2F3QB@1|root,33WH4@2|Bacteria,2H50W@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_1026776_11	1313172.YM304_37680	2.823e-81	281.0	COG0037@1|root,COG0037@2|Bacteria,2GJR4@201174|Actinobacteria,4CN76@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3
REGS3_k127_1026776_8	1229780.BN381_110020	3.123e-83	290.0	COG5282@1|root,COG5282@2|Bacteria,2GJ8E@201174|Actinobacteria,3UXC9@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	Pfam:Zinicin_2	-	-	-	-	-	-	-	-	-	-	-	-	Zincin_2
REGS3_k127_1026776_18	1313172.YM304_37660	3.23e-28	117.0	29XP9@1|root,30JEV@2|Bacteria,2HGER@201174|Actinobacteria,4CNCS@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
REGS3_k127_1026776_12	1313172.YM304_37650	3.6e-81	276.0	COG1595@1|root,COG1595@2|Bacteria,2GJ02@201174|Actinobacteria,4CMZF@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Sigma-70, region 4	sigR	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
REGS3_k127_1026776_17	1313172.YM304_37640	5.555e-34	138.0	COG1846@1|root,COG1846@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	2.1.1.303	ko:K04096,ko:K20421	ko01059,ko01130,map01059,map01130	M00830	R10963	RC00003,RC00392	ko00000,ko00001,ko00002,ko01000	-	-	-	DNA_processg_A,HTH_34,MarR_2,Methyltransf_2,PRiA4_ORF3
REGS3_k127_1026776_10	1313172.YM304_16580	1.188e-81	283.0	COG1073@1|root,COG1073@2|Bacteria	2|Bacteria	S	thiolester hydrolase activity	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
REGS3_k127_1026776_21	443218.AS9A_2871	4.319e-10	71.0	COG2852@1|root,COG2852@2|Bacteria,2GNZQ@201174|Actinobacteria,233FA@1762|Mycobacteriaceae	201174|Actinobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF559
REGS3_k127_1026776_16	1313172.YM304_01750	3.744e-35	140.0	COG3467@1|root,COG3467@2|Bacteria	2|Bacteria	T	pyridoxamine 5'-phosphate	pdxH	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Putative_PNPOx,Pyridox_ox_2
REGS3_k127_1026776_5	1313172.YM304_03460	3.278e-107	361.0	COG0470@1|root,COG0470@2|Bacteria	2|Bacteria	L	replication factor c	holB	-	2.7.7.7	ko:K02341,ko:K02343,ko:K09384	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNApol3-delta_C
REGS3_k127_1026776_13	1313172.YM304_03470	6.689e-65	229.0	COG0125@1|root,COG0125@2|Bacteria,2HF93@201174|Actinobacteria,4CNDK@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
REGS3_k127_1026776_7	1313172.YM304_11680	4.668e-88	300.0	COG0697@1|root,COG0697@2|Bacteria	2|Bacteria	EG	spore germination	-	-	-	-	-	-	-	-	-	-	-	-	EamA
REGS3_k127_1026776_20	1313172.YM304_03480	1.814e-25	108.0	COG0550@1|root,COG1754@1|root,COG0550@2|Bacteria,COG1754@2|Bacteria,2GJU7@201174|Actinobacteria,4CMPI@84992|Acidimicrobiia	84992|Acidimicrobiia	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,Toprim_C_rpt
REGS3_k127_1060904_2	1313172.YM304_11450	7.745e-157	501.0	COG0059@1|root,COG0059@2|Bacteria,2GKXA@201174|Actinobacteria,4CMV2@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
REGS3_k127_1060904_6	557599.MKAN_22895	7.493e-20	98.0	COG1414@1|root,COG1414@2|Bacteria,2I9N3@201174|Actinobacteria	201174|Actinobacteria	K	Bacterial transcriptional regulator	-	-	-	ko:K13641	-	-	-	-	ko00000,ko03000	-	-	-	HTH_IclR,IclR
REGS3_k127_1060904_1	298654.FraEuI1c_1623	4.63e-189	599.0	COG2159@1|root,COG2159@2|Bacteria,2GP2D@201174|Actinobacteria,4EUJC@85013|Frankiales	201174|Actinobacteria	S	PFAM Amidohydrolase 2	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
REGS3_k127_1060904_4	298655.KI912267_gene7626	9.378e-92	309.0	COG4689@1|root,COG4689@2|Bacteria,2I8M2@201174|Actinobacteria	201174|Actinobacteria	Q	acetoacetate decarboxylase	-	-	4.1.1.4	ko:K01574	ko00072,ko00640,ko01100,map00072,map00640,map01100	M00088	R01366	RC00040	ko00000,ko00001,ko00002,ko01000	-	-	-	ADC
REGS3_k127_1060904_3	1229780.BN381_130371	3.248e-103	346.0	COG4221@1|root,COG4221@2|Bacteria,2HA4H@201174|Actinobacteria,3UXFS@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
REGS3_k127_1060904_0	1123320.KB889679_gene2372	9.994e-212	673.0	COG2159@1|root,COG2159@2|Bacteria,2HG7W@201174|Actinobacteria	201174|Actinobacteria	S	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
REGS3_k127_1060904_5	1313172.YM304_11500	1.643e-74	253.0	COG2873@1|root,COG2873@2|Bacteria,2I2EB@201174|Actinobacteria,4CNG3@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Cys/Met metabolism PLP-dependent enzyme	-	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
REGS3_k127_1062406_1	222534.KB893722_gene513	2.959e-164	534.0	COG3653@1|root,COG3653@2|Bacteria,2IE6H@201174|Actinobacteria	201174|Actinobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
REGS3_k127_1062406_2	487521.OCU_21030	8.024e-153	493.0	COG2141@1|root,COG2141@2|Bacteria,2GKPX@201174|Actinobacteria,2335G@1762|Mycobacteriaceae	201174|Actinobacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
REGS3_k127_1062406_3	1120950.KB892771_gene1287	4.933e-111	367.0	COG2141@1|root,COG2141@2|Bacteria,2GM7W@201174|Actinobacteria,4DPZ7@85009|Propionibacteriales	201174|Actinobacteria	C	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_33,Bac_luciferase
REGS3_k127_1062406_0	1313172.YM304_00140	9.697e-173	551.0	COG2239@1|root,COG2239@2|Bacteria,2GMMK@201174|Actinobacteria,4CN6N@84992|Acidimicrobiia	84992|Acidimicrobiia	P	MgtE intracellular N domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,MgtE_N
REGS3_k127_1062406_5	1313172.YM304_00130	3.352e-44	168.0	COG4420@1|root,COG4420@2|Bacteria,2GJRV@201174|Actinobacteria	201174|Actinobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF1003
REGS3_k127_1062406_4	1313172.YM304_00120	1.36e-77	267.0	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	-	-	3.4.11.5	ko:K01259,ko:K19311	ko00330,map00330	-	R00135	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Abhydrolase_1,Hydrolase_4
REGS3_k127_1080655_3	1313172.YM304_22620	1.457e-46	173.0	COG0131@1|root,COG0131@2|Bacteria,2GKMD@201174|Actinobacteria,4CN2F@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Imidazoleglycerol-phosphate dehydratase	hisB	-	4.2.1.19	ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03457	RC00932	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPD
REGS3_k127_1080655_0	1313172.YM304_22610	5.901e-171	542.0	COG0079@1|root,COG0079@2|Bacteria,2GJ9W@201174|Actinobacteria,4CMYU@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
REGS3_k127_1080655_2	1451189.CFAL_11075	6.514e-71	246.0	COG0177@1|root,COG0177@2|Bacteria,2GJ01@201174|Actinobacteria,22KIT@1653|Corynebacteriaceae	201174|Actinobacteria	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0030312,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
REGS3_k127_1080655_1	1313172.YM304_22590	6.448e-76	269.0	COG0454@1|root,COG0456@2|Bacteria,2GM35@201174|Actinobacteria,4CN0X@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol	mshD	-	2.3.1.189	ko:K15520	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1
REGS3_k127_1080655_4	1313172.YM304_22580	2.249e-10	63.0	COG1164@1|root,COG1164@2|Bacteria,2IGPX@201174|Actinobacteria	201174|Actinobacteria	E	Oligopeptidase F	pepF	-	-	ko:K08602	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3,Peptidase_M3_N
REGS3_k127_113405_26	1123024.AUII01000022_gene129	5.208e-34	139.0	COG2197@1|root,COG2197@2|Bacteria,2I321@201174|Actinobacteria,4EF7G@85010|Pseudonocardiales	201174|Actinobacteria	KT	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
REGS3_k127_113405_27	1463920.JOGB01000054_gene4485	8.462e-29	124.0	COG1122@1|root,COG1122@2|Bacteria,2GK4F@201174|Actinobacteria	201174|Actinobacteria	P	Spherulation-specific family 4	-	-	-	-	-	-	-	-	-	-	-	-	Spherulin4
REGS3_k127_113405_2	1313172.YM304_19650	7.631e-272	854.0	COG1331@1|root,COG1331@2|Bacteria,2GJ88@201174|Actinobacteria,4CMYD@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	Thioredox_DsbH
REGS3_k127_113405_19	1121403.AUCV01000013_gene3919	1.162e-52	205.0	COG3868@1|root,COG3868@2|Bacteria,1PIK8@1224|Proteobacteria,42QZ4@68525|delta/epsilon subdivisions,2WUIV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Glycoside-hydrolase family GH114	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_114
REGS3_k127_113405_15	1313172.YM304_19640	3.524e-74	254.0	COG0778@1|root,COG0778@2|Bacteria,2GW57@201174|Actinobacteria,4CN7W@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
REGS3_k127_113405_14	1313172.YM304_19630	7.59e-89	300.0	2BWZ3@1|root,33X4C@2|Bacteria,2H5EF@201174|Actinobacteria,4CN6H@84992|Acidimicrobiia	84992|Acidimicrobiia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_113405_0	1313172.YM304_19620	0.0	1839.0	COG0587@1|root,COG0587@2|Bacteria,2GJ1P@201174|Actinobacteria,4CMWT@84992|Acidimicrobiia	84992|Acidimicrobiia	L	DNA polymerase alpha chain like domain	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP
REGS3_k127_113405_21	1313172.YM304_19610	2.987e-49	181.0	291ZT@1|root,2ZPJ4@2|Bacteria,2GR7R@201174|Actinobacteria,4CN47@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Protein of unknown function (DUF2587)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2587
REGS3_k127_113405_8	1313172.YM304_19600	2.362e-137	447.0	COG1524@1|root,COG1524@2|Bacteria,2GISU@201174|Actinobacteria,4CMXF@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
REGS3_k127_113405_16	1313172.YM304_19590	1.58e-72	250.0	COG1959@1|root,COG1959@2|Bacteria,2HG5V@201174|Actinobacteria,4CN2Q@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
REGS3_k127_113405_12	1313172.YM304_19580	4.024e-104	348.0	COG0564@1|root,COG0564@2|Bacteria,2GIY1@201174|Actinobacteria,4CN1X@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Responsible for synthesis of pseudouridine from uracil	rluD	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2
REGS3_k127_113405_24	1313172.YM304_19570	1.825e-47	176.0	COG0597@1|root,COG0597@2|Bacteria,2HGGT@201174|Actinobacteria,4CNE4@84992|Acidimicrobiia	84992|Acidimicrobiia	MU	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	lspA	-	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
REGS3_k127_113405_23	1313172.YM304_19560	2.342e-48	186.0	COG1734@1|root,COG1734@2|Bacteria,2HH4M@201174|Actinobacteria,4CP4R@84992|Acidimicrobiia	84992|Acidimicrobiia	T	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_113405_30	323848.Nmul_A0579	5.82e-14	77.0	COG1872@1|root,COG1872@2|Bacteria,1MZ4E@1224|Proteobacteria,2VWDY@28216|Betaproteobacteria,373IG@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Belongs to the UPF0235 family	-	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
REGS3_k127_113405_1	1313172.YM304_19550	0.0	1534.0	COG0060@1|root,COG0060@2|Bacteria,2GK9M@201174|Actinobacteria,4CMSP@84992|Acidimicrobiia	84992|Acidimicrobiia	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
REGS3_k127_113405_25	1313172.YM304_19540	1.695e-45	177.0	COG3599@1|root,COG3599@2|Bacteria	2|Bacteria	D	regulation of cell shape	-	-	-	-	-	-	-	-	-	-	-	-	DivIVA
REGS3_k127_113405_20	1313172.YM304_19530	4.402e-51	189.0	COG1799@1|root,COG1799@2|Bacteria,2HGHD@201174|Actinobacteria,4CNES@84992|Acidimicrobiia	84992|Acidimicrobiia	D	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA	sepF	-	-	ko:K09772	-	-	-	-	ko00000,ko03036	-	-	-	SepF
REGS3_k127_113405_17	1313172.YM304_19520	1.017e-55	202.0	COG0325@1|root,COG0325@2|Bacteria,2HGAF@201174|Actinobacteria,4CN9H@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Alanine racemase, N-terminal domain	-	-	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
REGS3_k127_113405_4	1313172.YM304_19500	1.473e-182	576.0	COG0206@1|root,COG0206@2|Bacteria,2GJWC@201174|Actinobacteria,4CMR8@84992|Acidimicrobiia	84992|Acidimicrobiia	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
REGS3_k127_113405_22	1313172.YM304_19490	2.006e-48	191.0	COG1589@1|root,COG1589@2|Bacteria	2|Bacteria	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly	ftsQ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0071944	6.3.2.4	ko:K01921,ko:K03589,ko:K06438	ko00473,ko00550,ko01100,ko01502,ko04112,map00473,map00550,map01100,map01502,map04112	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	FtsQ,POTRA_1
REGS3_k127_113405_13	1313172.YM304_19480	1.846e-94	321.0	COG0812@1|root,COG0812@2|Bacteria,2HG0Y@201174|Actinobacteria,4CMXR@84992|Acidimicrobiia	84992|Acidimicrobiia	M	Cell wall formation	murB	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
REGS3_k127_113405_3	1313172.YM304_19470	6.673e-205	651.0	COG0773@1|root,COG0773@2|Bacteria,2I2E7@201174|Actinobacteria,4CMTG@84992|Acidimicrobiia	84992|Acidimicrobiia	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
REGS3_k127_113405_18	246194.CHY_2069	1.037e-54	206.0	COG0707@1|root,COG0707@2|Bacteria,1TQFT@1239|Firmicutes,248IA@186801|Clostridia,42F8I@68295|Thermoanaerobacterales	186801|Clostridia	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
REGS3_k127_113405_10	1313172.YM304_19450	1.349e-115	385.0	COG0772@1|root,COG0772@2|Bacteria,2GKXP@201174|Actinobacteria,4CN6S@84992|Acidimicrobiia	84992|Acidimicrobiia	D	Cell cycle protein	-	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
REGS3_k127_113405_7	1313172.YM304_19440	4.962e-154	499.0	COG0771@1|root,COG0771@2|Bacteria,2GJZA@201174|Actinobacteria,4CN07@84992|Acidimicrobiia	84992|Acidimicrobiia	D	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase_C,Mur_ligase_M
REGS3_k127_113405_6	1313172.YM304_19430	4.623e-156	500.0	COG0472@1|root,COG0472@2|Bacteria,2GNEH@201174|Actinobacteria,4CMYF@84992|Acidimicrobiia	84992|Acidimicrobiia	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
REGS3_k127_113405_9	1313172.YM304_19420	2.747e-127	424.0	COG0769@1|root,COG0769@2|Bacteria,2GIS2@201174|Actinobacteria,4CNID@84992|Acidimicrobiia	84992|Acidimicrobiia	M	acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	-	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
REGS3_k127_113405_5	1313172.YM304_19410	1.102e-165	548.0	COG0768@1|root,COG0768@2|Bacteria,2GKHH@201174|Actinobacteria,4CN0Q@84992|Acidimicrobiia	84992|Acidimicrobiia	M	Penicillin-binding Protein dimerisation domain	-	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PBP_dimer,Transpeptidase
REGS3_k127_113405_11	1313172.YM304_19390	7.89e-114	378.0	COG0275@1|root,COG0275@2|Bacteria,2GJGK@201174|Actinobacteria,4CN25@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	-	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
REGS3_k127_113405_28	1313172.YM304_19380	1.401e-25	111.0	COG2001@1|root,COG2001@2|Bacteria,2IHUB@201174|Actinobacteria,4CNC7@84992|Acidimicrobiia	84992|Acidimicrobiia	K	MraZ protein, putative antitoxin-like	mraZ	-	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
REGS3_k127_1136876_14	983917.RGE_22560	2.725e-43	168.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,1KJEE@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_3,PAS_4,Response_reg
REGS3_k127_1136876_19	247634.GPB2148_2030	5.963e-30	131.0	2FER6@1|root,346Q9@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_1136876_24	172088.AUGA01000043_gene4903	1.832e-10	74.0	COG3921@1|root,COG5283@1|root,COG3921@2|Bacteria,COG5283@2|Bacteria,1QWJX@1224|Proteobacteria	1224|Proteobacteria	S	D-alanyl-D-alanine carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M15_4
REGS3_k127_1136876_18	452863.Achl_3348	2.833e-30	139.0	COG4932@1|root,COG4932@2|Bacteria	2|Bacteria	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Cellulase,MucBP,Peptidase_S8,SLH
REGS3_k127_1136876_13	1313172.YM304_02770	1.194e-50	195.0	COG0500@1|root,COG2226@2|Bacteria,2IGKC@201174|Actinobacteria	201174|Actinobacteria	Q	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
REGS3_k127_1136876_16	2074.JNYD01000002_gene5577	1.356e-37	151.0	COG0599@1|root,COG0599@2|Bacteria,2IRPW@201174|Actinobacteria,4EBM4@85010|Pseudonocardiales	201174|Actinobacteria	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
REGS3_k127_1136876_8	1146883.BLASA_3968	2.102e-120	401.0	COG0520@1|root,COG0520@2|Bacteria,2GMIC@201174|Actinobacteria,4EUQQ@85013|Frankiales	201174|Actinobacteria	E	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
REGS3_k127_1136876_4	101510.RHA1_ro06944	5.826e-180	575.0	COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,2GN50@201174|Actinobacteria,4FU1R@85025|Nocardiaceae	201174|Actinobacteria	P	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B,Rhodanese
REGS3_k127_1136876_20	1229780.BN381_130242	1.814e-25	108.0	COG1937@1|root,COG1937@2|Bacteria,2IQ7U@201174|Actinobacteria,3UWY5@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	Metal-sensitive transcriptional repressor	csoR	-	-	-	-	-	-	-	-	-	-	-	Trns_repr_metal
REGS3_k127_1136876_25	41875.XP_007515728.1	2.287e-10	63.0	2D04E@1|root,2SCRY@2759|Eukaryota	2759|Eukaryota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_1136876_0	1229780.BN381_640016	8.579e-202	637.0	COG0863@1|root,COG0863@2|Bacteria	2|Bacteria	L	N-4 methylation of cytosine	bglIM	-	2.1.1.113,2.1.1.72	ko:K00571,ko:K00590	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
REGS3_k127_1136876_3	1306174.JODP01000009_gene6409	1.048e-185	598.0	COG1502@1|root,COG1502@2|Bacteria,2GN2V@201174|Actinobacteria	201174|Actinobacteria	I	Phospholipase D Transphosphatidylase	-	-	-	-	-	-	-	-	-	-	-	-	PLDc,PLDc_2
REGS3_k127_1136876_11	1313172.YM304_02170	2.135e-81	278.0	COG1716@1|root,COG1716@2|Bacteria,2HG8X@201174|Actinobacteria,4CN6T@84992|Acidimicrobiia	84992|Acidimicrobiia	T	Protein of unknown function (DUF2662)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3662,FHA
REGS3_k127_1136876_15	1313172.YM304_02160	2.632e-42	161.0	COG1716@1|root,COG1716@2|Bacteria,2HGEP@201174|Actinobacteria,4CNCQ@84992|Acidimicrobiia	84992|Acidimicrobiia	T	Forkhead associated domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA
REGS3_k127_1136876_9	1313172.YM304_02150	9.422e-99	340.0	COG0631@1|root,COG0631@2|Bacteria,2GJ3M@201174|Actinobacteria,4CN1S@84992|Acidimicrobiia	84992|Acidimicrobiia	T	Sigma factor PP2C-like phosphatases	-	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C_2
REGS3_k127_1136876_1	1313172.YM304_02140	9.541e-196	624.0	COG0772@1|root,COG0772@2|Bacteria,2GJTI@201174|Actinobacteria,4CMWK@84992|Acidimicrobiia	84992|Acidimicrobiia	D	Cell cycle protein	-	-	-	-	-	-	-	-	-	-	-	-	FTSW_RODA_SPOVE
REGS3_k127_1136876_7	1313172.YM304_02130	3.909e-151	494.0	COG0768@1|root,COG0768@2|Bacteria,2GJUQ@201174|Actinobacteria,4CMY4@84992|Acidimicrobiia	84992|Acidimicrobiia	M	Penicillin binding protein transpeptidase domain	-	-	-	ko:K05364	ko00550,map00550	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01011	-	-	-	Transpeptidase
REGS3_k127_1136876_2	1313172.YM304_02120	3.844e-191	619.0	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,2GJ1J@201174|Actinobacteria,4CMUZ@84992|Acidimicrobiia	84992|Acidimicrobiia	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
REGS3_k127_1136876_10	1313172.YM304_02070	1.835e-88	298.0	COG0512@1|root,COG0512@2|Bacteria,2GJUX@201174|Actinobacteria,4CN3U@84992|Acidimicrobiia	84992|Acidimicrobiia	EH	Peptidase C26	-	-	2.6.1.85,4.1.3.27	ko:K01658,ko:K01664	ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986,R01716	RC00010,RC01418,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
REGS3_k127_1136876_17	1313172.YM304_02050	5.809e-34	132.0	28YVQ@1|root,2ZKNY@2|Bacteria,2HCMJ@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_1136876_5	1313172.YM304_02040	5.226e-176	563.0	COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria,4CMTJ@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Belongs to the thiolase family	-	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
REGS3_k127_1136876_21	1313172.YM304_02030	6.083e-24	107.0	COG1846@1|root,COG1846@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	ko:K18996	-	-	-	-	ko00000,ko03032	-	-	-	MarR,RP-C,RP-C_C
REGS3_k127_1136876_6	1048339.KB913029_gene3544	2.121e-167	535.0	COG0160@1|root,COG0160@2|Bacteria,2GIS9@201174|Actinobacteria,4ERVR@85013|Frankiales	201174|Actinobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	gabT	-	2.6.1.19,2.6.1.22	ko:K00823,ko:K07250	ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648,R04188	RC00006,RC00062,RC00160	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
REGS3_k127_1136876_12	1313172.YM304_02000	1.62e-73	256.0	COG0446@1|root,COG0446@2|Bacteria,2GJKT@201174|Actinobacteria,4CN2E@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Reductase C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Reductase_C
REGS3_k127_1137222_5	1229780.BN381_130271	1.186e-51	186.0	COG0242@1|root,COG0242@2|Bacteria,2GNZ9@201174|Actinobacteria	201174|Actinobacteria	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0018193,GO:0018206,GO:0019538,GO:0031365,GO:0036211,GO:0042586,GO:0043170,GO:0043412,GO:0043686,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
REGS3_k127_1137222_0	1229780.BN381_130269	8.768e-295	911.0	COG2987@1|root,COG2987@2|Bacteria,2GP10@201174|Actinobacteria,3UX1W@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	H	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate	hutU	-	4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000	-	-	-	Urocanase,Urocanase_C,Urocanase_N
REGS3_k127_1137222_1	1283299.AUKG01000001_gene2498	3.227e-203	644.0	COG2986@1|root,COG2986@2|Bacteria,2GJZW@201174|Actinobacteria,4CPAC@84995|Rubrobacteria	84995|Rubrobacteria	E	PFAM phenylalanine histidine ammonia-lyase	-	-	4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
REGS3_k127_1137222_7	1306174.JODP01000001_gene5276	4.112e-31	136.0	COG1414@1|root,COG1414@2|Bacteria,2HVQ8@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR
REGS3_k127_1137222_3	1133850.SHJG_2292	3.239e-91	317.0	COG1680@1|root,COG1680@2|Bacteria,2GJJB@201174|Actinobacteria	201174|Actinobacteria	V	COG1680 Beta-lactamase class C and other penicillin binding proteins	lipP	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
REGS3_k127_1137222_4	1121946.AUAX01000011_gene4003	1.681e-52	194.0	COG0346@1|root,COG0346@2|Bacteria,2IFMD@201174|Actinobacteria,4DM35@85008|Micromonosporales	201174|Actinobacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_1137222_2	391625.PPSIR1_25106	1.032e-103	347.0	COG1670@1|root,COG1670@2|Bacteria	2|Bacteria	J	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins	-	-	-	ko:K03817	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_3
REGS3_k127_1137222_8	1380390.JIAT01000010_gene3622	2.041e-29	125.0	2DPKA@1|root,332H3@2|Bacteria,2I2YH@201174|Actinobacteria,4CQ8H@84995|Rubrobacteria	84995|Rubrobacteria	S	Domain of unknown function (DUF4389)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4389
REGS3_k127_1137222_6	926559.JoomaDRAFT_3511	7.206e-51	187.0	COG3525@1|root,COG3525@2|Bacteria,4NK7H@976|Bacteroidetes,1I4CS@117743|Flavobacteriia	976|Bacteroidetes	G	Glycosyl hydrolase family 20, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_20,Glyco_hydro_20b
REGS3_k127_1172767_13	365528.KB891103_gene3844	2.075e-39	148.0	COG0778@1|root,COG0778@2|Bacteria,2I94X@201174|Actinobacteria	201174|Actinobacteria	C	Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
REGS3_k127_1172767_2	1313172.YM304_20100	1.263e-174	559.0	COG1070@1|root,COG1070@2|Bacteria,2GJDZ@201174|Actinobacteria	201174|Actinobacteria	G	xylulose kinase	xylB	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
REGS3_k127_1172767_14	1313172.YM304_20110	4.372e-33	143.0	COG2214@1|root,COG2214@2|Bacteria	2|Bacteria	O	Heat shock protein DnaJ domain protein	-	-	-	ko:K05516	-	-	-	-	ko00000,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C,TPR_2,WD40
REGS3_k127_1172767_5	1278073.MYSTI_01666	6.048e-93	317.0	COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,42T6S@68525|delta/epsilon subdivisions,2WP34@28221|Deltaproteobacteria,2YV20@29|Myxococcales	28221|Deltaproteobacteria	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine	yrdC1	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	SUA5,Sua5_yciO_yrdC
REGS3_k127_1172767_8	1313172.YM304_20130	1.531e-77	266.0	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
REGS3_k127_1172767_0	1313172.YM304_20140	1.041e-234	737.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,2GKVS@201174|Actinobacteria,4CNDM@84992|Acidimicrobiia	84992|Acidimicrobiia	F	IMP dehydrogenase / GMP reductase domain	-	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
REGS3_k127_1172767_11	1313172.YM304_20150	3.3e-72	254.0	COG0283@1|root,COG0283@2|Bacteria,2H3SI@201174|Actinobacteria,4CNDQ@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Cytidylate kinase	cmk	-	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin
REGS3_k127_1172767_9	1313172.YM304_20160	1.118e-76	265.0	COG0204@1|root,COG0204@2|Bacteria,2HG51@201174|Actinobacteria,4CN6X@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Phosphate acyltransferases	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
REGS3_k127_1172767_3	1313172.YM304_20170	7.072e-174	557.0	COG1362@1|root,COG1362@2|Bacteria,2GKW4@201174|Actinobacteria	201174|Actinobacteria	E	M18 family aminopeptidase	apeB	GO:0003674,GO:0003824,GO:0004177,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0009987,GO:0016020,GO:0016787,GO:0019538,GO:0034641,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0070006,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564	3.4.11.21	ko:K01267	-	-	-	-	ko00000,ko01000,ko01002,ko04131	-	-	-	Peptidase_M18
REGS3_k127_1172767_10	1313172.YM304_20180	1.427e-73	252.0	COG0406@1|root,COG0406@2|Bacteria,2GM22@201174|Actinobacteria	201174|Actinobacteria	G	Phosphoglycerate mutase	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
REGS3_k127_1172767_1	1313172.YM304_20190	1.568e-185	591.0	COG0469@1|root,COG0469@2|Bacteria,2GJY8@201174|Actinobacteria,4CMXD@84992|Acidimicrobiia	84992|Acidimicrobiia	G	Pyruvate kinase, barrel domain	-	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
REGS3_k127_1172767_17	1283283.ATXA01000010_gene4499	1.298e-22	109.0	COG0596@1|root,COG0596@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on ester bonds	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
REGS3_k127_1172767_12	1313172.YM304_20220	1.488e-51	186.0	2DMMI@1|root,32SFN@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF3151)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3151
REGS3_k127_1172767_15	1313172.YM304_20230	1.898e-30	132.0	COG0746@1|root,COG0746@2|Bacteria	2|Bacteria	H	molybdenum cofactor guanylyltransferase activity	mobA	-	2.7.7.77,4.6.1.17	ko:K03637,ko:K03752,ko:K13818	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372,R11581	RC03425	ko00000,ko00001,ko01000	-	-	-	MobB,NTP_transf_3
REGS3_k127_1172767_16	1121933.AUHH01000035_gene134	4.671e-25	108.0	COG0607@1|root,COG0607@2|Bacteria,2IQIP@201174|Actinobacteria	201174|Actinobacteria	P	sulfurtransferase	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
REGS3_k127_1172767_4	1313172.YM304_20250	2.302e-148	481.0	COG0349@1|root,COG0349@2|Bacteria,2GKNM@201174|Actinobacteria,4CN02@84992|Acidimicrobiia	84992|Acidimicrobiia	J	3'-5' exonuclease	rnd	-	3.1.13.5	ko:K03684	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DNA_pol_A_exo1,HRDC
REGS3_k127_1172767_6	1313172.YM304_20260	1.401e-89	302.0	COG1192@1|root,COG1192@2|Bacteria,2H4UC@201174|Actinobacteria	201174|Actinobacteria	D	chromosome partitioning	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
REGS3_k127_1172767_7	1146883.BLASA_4994	1.605e-78	270.0	COG0366@1|root,COG0366@2|Bacteria,2GKS4@201174|Actinobacteria,4ERW2@85013|Frankiales	201174|Actinobacteria	G	SMART alpha amylase, catalytic sub domain	-	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	Alpha-amylase,DUF3459
REGS3_k127_1178275_9	983920.Y88_1674	3.504e-11	70.0	COG4638@1|root,COG4638@2|Bacteria,1MWXW@1224|Proteobacteria,2TVNW@28211|Alphaproteobacteria,2K33H@204457|Sphingomonadales	204457|Sphingomonadales	P	Rieske 2Fe-2S	-	-	-	-	-	-	-	-	-	-	-	-	Rieske,Ring_hydroxyl_A
REGS3_k127_1178275_3	1313172.YM304_42230	3.344e-188	601.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria	201174|Actinobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.48	ko:K02182	-	-	-	-	ko00000,ko01000	-	-	-	AMP-binding,AMP-binding_C
REGS3_k127_1178275_1	1313172.YM304_42240	4.128e-269	836.0	COG0146@1|root,COG0146@2|Bacteria,2HWA8@201174|Actinobacteria,4CNVH@84992|Acidimicrobiia	84992|Acidimicrobiia	EQ	Protein synonym hydantoin utilization protein B	-	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
REGS3_k127_1178275_0	1313172.YM304_42250	0.0	1009.0	COG0145@1|root,COG0145@2|Bacteria,2GIYE@201174|Actinobacteria,4CNGA@84992|Acidimicrobiia	84992|Acidimicrobiia	EQ	Protein synonym hydantoin utilization protein A	-	-	3.5.2.14	ko:K01473	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A
REGS3_k127_1178275_5	1313172.YM304_42260	2.547e-45	177.0	COG0662@1|root,COG0662@2|Bacteria,2H8T0@201174|Actinobacteria	201174|Actinobacteria	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
REGS3_k127_1178275_4	1123320.KB889681_gene2598	1.142e-56	207.0	COG2186@1|root,COG2186@2|Bacteria	2|Bacteria	K	Transcriptional regulator	-	-	-	ko:K05799	-	-	-	-	ko00000,ko03000	-	-	-	FCD,GntR
REGS3_k127_1178275_8	1313172.YM304_06320	1.785e-12	70.0	2DCWG@1|root,2ZFKS@2|Bacteria	2|Bacteria	S	CsbD-like	-	-	-	-	-	-	-	-	-	-	-	-	CsbD
REGS3_k127_1178275_2	926562.Oweho_2792	3.092e-221	746.0	COG1409@1|root,COG1409@2|Bacteria,4NEQ8@976|Bacteroidetes,1I0MD@117743|Flavobacteriia	976|Bacteroidetes	S	Ser Thr phosphatase family protein	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
REGS3_k127_1178275_7	105425.BBPL01000026_gene514	2.965e-15	92.0	COG1502@1|root,COG4412@1|root,COG1502@2|Bacteria,COG4412@2|Bacteria,2HA2M@201174|Actinobacteria,2NEGY@228398|Streptacidiphilus	201174|Actinobacteria	EI	PLD-like domain	-	-	-	-	-	-	-	-	-	-	-	-	He_PIG,PLDc_2
REGS3_k127_1178275_6	1121011.AUCB01000008_gene1243	4.518e-27	131.0	COG3291@1|root,COG3637@1|root,COG3291@2|Bacteria,COG3637@2|Bacteria	2|Bacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	omp-1X	-	-	ko:K12976,ko:K22110	-	-	-	-	ko00000,ko01000,ko01005,ko02000	1.B.35.1,1.B.35.2	-	-	CHB_HEX_C_1,PKD,PagL,Surface_Ag_2
REGS3_k127_1187417_18	1197706.AKKK01000009_gene484	7.672e-41	165.0	COG0058@1|root,COG0058@2|Bacteria,2GIVZ@201174|Actinobacteria,1W8A2@1268|Micrococcaceae	201174|Actinobacteria	G	Protein of unknown function (DUF3417)	glgP	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
REGS3_k127_1187417_9	1313172.YM304_10820	2.255e-134	440.0	COG0297@1|root,COG0297@2|Bacteria,2I2EE@201174|Actinobacteria	201174|Actinobacteria	G	PFAM Glycosyl transferase, group 1	-	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0033692,GO:0034637,GO:0034645,GO:0040007,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.4.1.11	ko:K16150	ko00500,ko01100,map00500,map01100	-	R00292	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT4	-	Glyco_transf_4,Glycos_transf_1
REGS3_k127_1187417_1	1313172.YM304_10830	4.066e-275	860.0	COG0296@1|root,COG0296@2|Bacteria,2GJ5C@201174|Actinobacteria	201174|Actinobacteria	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	GO:0000271,GO:0003674,GO:0003824,GO:0003844,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016020,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0040007,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0055114,GO:0071704,GO:0071944,GO:1901576	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
REGS3_k127_1187417_16	1385521.N803_00970	2.212e-45	175.0	COG1296@1|root,COG1296@2|Bacteria,2GN6R@201174|Actinobacteria,4FFT4@85021|Intrasporangiaceae	201174|Actinobacteria	E	branched-chain amino acid	-	-	-	-	-	-	-	-	-	-	-	-	AzlC
REGS3_k127_1187417_23	446470.Snas_2052	0.0003097	51.0	2DMQN@1|root,32T1U@2|Bacteria,2GS5T@201174|Actinobacteria,4F036@85014|Glycomycetales	201174|Actinobacteria	S	Branched-chain amino acid transport protein (AzlD)	-	-	-	-	-	-	-	-	-	-	-	-	AzlD
REGS3_k127_1187417_14	1313172.YM304_10850	4.718e-60	210.0	COG3427@1|root,COG3427@2|Bacteria,2HGAK@201174|Actinobacteria,4CNA2@84992|Acidimicrobiia	84992|Acidimicrobiia	E	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
REGS3_k127_1187417_6	1313172.YM304_10860	1.137e-145	469.0	COG1085@1|root,COG1085@2|Bacteria,2I2DM@201174|Actinobacteria,4CMV6@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Domain of unknown function (DUF4921)	-	-	2.7.7.12	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	M00362,M00554,M00632	R00955	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	GalP_UDP_transf
REGS3_k127_1187417_12	1313172.YM304_12290	1.127e-74	261.0	COG0500@1|root,COG0500@2|Bacteria,2I3YC@201174|Actinobacteria	201174|Actinobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
REGS3_k127_1187417_5	1313172.YM304_12550	3.996e-154	504.0	COG1104@1|root,COG1104@2|Bacteria,2GKUT@201174|Actinobacteria,4CN5Q@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Aminotransferase class-V	-	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
REGS3_k127_1187417_4	1313172.YM304_12560	5.828e-156	502.0	COG0482@1|root,COG0482@2|Bacteria,2GIUQ@201174|Actinobacteria,4CMY8@84992|Acidimicrobiia	84992|Acidimicrobiia	J	tRNA methyl transferase	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
REGS3_k127_1187417_17	1313172.YM304_12570	5.629e-45	174.0	2CDEB@1|root,2ZRID@2|Bacteria,2HDK8@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_1187417_11	1313172.YM304_12580	4.035e-90	308.0	COG0620@1|root,COG0620@2|Bacteria	2|Bacteria	E	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation	-	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
REGS3_k127_1187417_3	1229780.BN381_10084	6.172e-244	770.0	COG0272@1|root,COG0272@2|Bacteria,2GJUY@201174|Actinobacteria,3UW7F@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
REGS3_k127_1187417_8	1313172.YM304_12630	2.353e-141	472.0	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,2GJ1J@201174|Actinobacteria	201174|Actinobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase,Pkinase_Tyr
REGS3_k127_1187417_7	1313172.YM304_12640	2.485e-144	464.0	COG1028@1|root,COG1028@2|Bacteria,2GJ1F@201174|Actinobacteria,4CMRY@84992|Acidimicrobiia	201174|Actinobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
REGS3_k127_1187417_13	1380356.JNIK01000002_gene4823	9.22e-66	244.0	COG0477@1|root,COG2814@2|Bacteria,2H1TJ@201174|Actinobacteria,4EUWV@85013|Frankiales	201174|Actinobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
REGS3_k127_1187417_15	1313172.YM304_12650	1.613e-48	177.0	COG3255@1|root,COG3255@2|Bacteria,2HGCC@201174|Actinobacteria,4CNAG@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Sterol carrier protein	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_1187417_2	1313172.YM304_12700	6.05e-244	773.0	COG0111@1|root,COG0111@2|Bacteria,2GJGA@201174|Actinobacteria,4CMQA@84992|Acidimicrobiia	84992|Acidimicrobiia	EH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	serA	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
REGS3_k127_1187417_10	1095769.CAHF01000013_gene3242	1.383e-105	349.0	COG0284@1|root,COG0284@2|Bacteria,1MWH5@1224|Proteobacteria,2VHAB@28216|Betaproteobacteria,4729B@75682|Oxalobacteraceae	28216|Betaproteobacteria	F	Belongs to the OMP decarboxylase family. Type 2 subfamily	pyrF	-	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
REGS3_k127_1187417_19	1313172.YM304_12730	2.787e-26	109.0	COG1141@1|root,COG1141@2|Bacteria,2HH2S@201174|Actinobacteria,4CP2W@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Divergent 4Fe-4S mono-cluster	-	-	-	ko:K05337	-	-	-	-	ko00000	-	-	-	Fer4_13
REGS3_k127_1187417_22	1313172.YM304_12740	2.118e-14	80.0	COG1525@1|root,COG1525@2|Bacteria	2|Bacteria	L	nuclease	-	-	3.1.31.1	ko:K01174	-	-	-	-	ko00000,ko01000	-	-	-	Ada_Zn_binding,Excalibur,SNase
REGS3_k127_1187417_0	1229780.BN381_450030	3.699e-277	861.0	COG0119@1|root,COG0119@2|Bacteria,2GISX@201174|Actinobacteria,3UW8G@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
REGS3_k127_1187417_21	1416759.AYMR01000036_gene3811	8.461e-16	85.0	COG0845@1|root,COG0845@2|Bacteria,2IH5S@201174|Actinobacteria,4FNHZ@85023|Microbacteriaceae	201174|Actinobacteria	M	Putative peptidoglycan binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_3,PG_binding_1
REGS3_k127_1195504_8	1229780.BN381_10132	8.864e-35	134.0	COG3250@1|root,COG3250@2|Bacteria,2I952@201174|Actinobacteria	201174|Actinobacteria	G	Protein of unknown function (DUF2804)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2804
REGS3_k127_1195504_2	1313172.YM304_08530	6.976e-127	409.0	COG3828@1|root,COG3828@2|Bacteria,2IB11@201174|Actinobacteria	201174|Actinobacteria	S	Trehalose utilisation	-	-	-	ko:K09992	-	-	-	-	ko00000	-	-	-	ThuA
REGS3_k127_1195504_3	1313172.YM304_08540	3.319e-108	357.0	COG1028@1|root,COG1028@2|Bacteria,2GMEH@201174|Actinobacteria	201174|Actinobacteria	IQ	Short-chain dehydrogenase reductase sdr	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
REGS3_k127_1195504_1	1313172.YM304_16710	2.237e-175	559.0	COG1960@1|root,COG1960@2|Bacteria,2GJDT@201174|Actinobacteria	201174|Actinobacteria	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
REGS3_k127_1195504_7	1313172.YM304_08560	8.601e-54	198.0	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	luxT	-	-	-	-	-	-	-	-	-	-	-	TetR_N
REGS3_k127_1195504_9	247634.GPB2148_3790	1.162e-22	103.0	COG1359@1|root,COG1359@2|Bacteria	2|Bacteria	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
REGS3_k127_1195504_4	247634.GPB2148_3275	2.298e-82	282.0	COG1028@1|root,COG1028@2|Bacteria,1R413@1224|Proteobacteria,1S3TR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
REGS3_k127_1195504_6	543632.JOJL01000012_gene6615	1.588e-70	248.0	COG1028@1|root,COG1028@2|Bacteria,2GJQC@201174|Actinobacteria	201174|Actinobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
REGS3_k127_1195504_0	1313172.YM304_16700	1.299e-221	709.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4CMUG@84992|Acidimicrobiia	201174|Actinobacteria	IQ	Protein synonym acyl-CoA synthetase	-	-	6.2.1.7	ko:K00666,ko:K15868	ko00121,map00121	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
REGS3_k127_1195504_5	247634.GPB2148_3101	1.222e-77	273.0	COG2141@1|root,COG2141@2|Bacteria	2|Bacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
REGS3_k127_1202065_14	1121272.KB903251_gene855	5.123e-35	141.0	2C7TJ@1|root,31RF6@2|Bacteria,2GP9X@201174|Actinobacteria,4D9XX@85008|Micromonosporales	201174|Actinobacteria	G	Mycothiol maleylpyruvate isomerase N-terminal domain	-	-	5.2.1.4	ko:K16163	ko00350,ko01100,ko01120,map00350,map01100,map01120	-	R03868	RC00867	ko00000,ko00001,ko01000	-	-	-	MDMPI_C,MDMPI_N
REGS3_k127_1202065_5	1313172.YM304_11700	3.631e-151	486.0	COG1023@1|root,COG1023@2|Bacteria,2I2DH@201174|Actinobacteria,4CMUX@84992|Acidimicrobiia	84992|Acidimicrobiia	G	6-phosphogluconate dehydrogenase, C-terminal domain	-	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
REGS3_k127_1202065_1	1313172.YM304_11690	4.28e-229	719.0	COG0364@1|root,COG0364@2|Bacteria,2GISI@201174|Actinobacteria,4CNFV@84992|Acidimicrobiia	84992|Acidimicrobiia	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	-	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
REGS3_k127_1202065_10	1313172.YM304_11620	6.482e-84	297.0	COG1120@1|root,COG1120@2|Bacteria,2IA4F@201174|Actinobacteria	201174|Actinobacteria	HP	ABC transporter	-	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
REGS3_k127_1202065_7	1313172.YM304_11610	9.987e-116	383.0	COG0609@1|root,COG0609@2|Bacteria,2GK8Z@201174|Actinobacteria	201174|Actinobacteria	P	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily	-	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
REGS3_k127_1202065_9	1120949.KB903318_gene2045	7.867e-89	305.0	COG0614@1|root,COG0614@2|Bacteria,2I2MI@201174|Actinobacteria,4D8H9@85008|Micromonosporales	201174|Actinobacteria	P	ABC-type Fe3 -hydroxamate transport system, periplasmic component	yvrC	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
REGS3_k127_1202065_11	1313172.YM304_11590	7.973e-79	272.0	COG2109@1|root,COG2109@2|Bacteria,2GNJQ@201174|Actinobacteria,4CN3K@84992|Acidimicrobiia	84992|Acidimicrobiia	H	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP	cobO	-	2.5.1.17	ko:K19221	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	CobA_CobO_BtuR
REGS3_k127_1202065_13	1313172.YM304_11580	5.504e-52	189.0	COG2087@1|root,COG2087@2|Bacteria,2GM8Q@201174|Actinobacteria,4CND7@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Cobinamide kinase / cobinamide phosphate guanyltransferase	cobP	-	2.7.1.156,2.7.7.62	ko:K02231	ko00860,ko01100,map00860,map01100	M00122	R05221,R05222,R06558	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	CobU
REGS3_k127_1202065_6	1313172.YM304_11570	5.621e-130	423.0	COG2038@1|root,COG2038@2|Bacteria,2GJ16@201174|Actinobacteria,4CN1T@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB)	cobT	-	2.4.2.21	ko:K00768	ko00860,ko01100,map00860,map01100	M00122	R04148	RC00033,RC00063	ko00000,ko00001,ko00002,ko01000	-	-	-	DBI_PRT
REGS3_k127_1202065_12	1313172.YM304_11560	5.977e-73	253.0	COG0368@1|root,COG0368@2|Bacteria,2HGZT@201174|Actinobacteria,4CP01@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate	cobS	-	2.7.8.26	ko:K02233	ko00860,ko01100,map00860,map01100	M00122	R05223,R11174	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CobS
REGS3_k127_1202065_0	987059.RBXJA2T_19641	1.458e-274	854.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2VIEX@28216|Betaproteobacteria,1KJSK@119065|unclassified Burkholderiales	28216|Betaproteobacteria	EH	Belongs to the TPP enzyme family	ilvG	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
REGS3_k127_1202065_2	1313172.YM304_11540	5.054e-190	622.0	COG0436@1|root,COG0436@2|Bacteria,2GJ7R@201174|Actinobacteria,4CMWF@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
REGS3_k127_1202065_3	1313172.YM304_11530	1.615e-168	536.0	COG1932@1|root,COG1932@2|Bacteria,2GKYK@201174|Actinobacteria,4CMWA@84992|Acidimicrobiia	84992|Acidimicrobiia	EH	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine	serC	-	2.6.1.52	ko:K00831	ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230	M00020,M00124	R04173,R05085	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
REGS3_k127_1202065_8	1313172.YM304_11520	3.834e-89	308.0	COG2047@1|root,COG2047@2|Bacteria,2I2H9@201174|Actinobacteria,4CN4A@84992|Acidimicrobiia	84992|Acidimicrobiia	S	PAC2 family	-	-	-	-	-	-	-	-	-	-	-	-	PAC2
REGS3_k127_1202065_4	1313172.YM304_11500	4.695e-166	526.0	COG2873@1|root,COG2873@2|Bacteria,2I2EB@201174|Actinobacteria,4CNG3@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Cys/Met metabolism PLP-dependent enzyme	-	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
REGS3_k127_1202219_1	1313172.YM304_21580	1.443e-235	732.0	COG0178@1|root,COG0178@2|Bacteria,2GJUV@201174|Actinobacteria,4CMUS@84992|Acidimicrobiia	84992|Acidimicrobiia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
REGS3_k127_1202219_5	1313172.YM304_21610	2.727e-39	157.0	COG0705@1|root,COG0705@2|Bacteria,2GRXN@201174|Actinobacteria	201174|Actinobacteria	S	Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_1202219_0	1313172.YM304_21620	5.803e-313	967.0	COG0322@1|root,COG0322@2|Bacteria,2GIS4@201174|Actinobacteria,4CMVA@84992|Acidimicrobiia	84992|Acidimicrobiia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,UVR,UvrC_HhH_N
REGS3_k127_1202219_3	1283287.KB822589_gene1227	2.125e-80	289.0	COG2141@1|root,COG2141@2|Bacteria,2GJ6T@201174|Actinobacteria,4DQAP@85009|Propionibacteriales	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
REGS3_k127_1202219_2	1313172.YM304_22760	8.471e-92	312.0	COG0861@1|root,COG0861@2|Bacteria,2GIWU@201174|Actinobacteria	201174|Actinobacteria	P	membrane protein terC	-	-	-	ko:K05794	-	-	-	-	ko00000	-	-	-	TerC
REGS3_k127_1202219_4	1313172.YM304_21650	3.675e-66	228.0	COG0500@1|root,COG2226@2|Bacteria,2HG5Z@201174|Actinobacteria,4CN2W@84992|Acidimicrobiia	84992|Acidimicrobiia	H	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
REGS3_k127_1292201_19	1313172.YM304_25800	2.628e-14	76.0	COG0739@1|root,COG3409@1|root,COG0739@2|Bacteria,COG3409@2|Bacteria,2IDIJ@201174|Actinobacteria	201174|Actinobacteria	M	Peptidoglycan-binding domain 1 protein	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1
REGS3_k127_1292201_16	1156844.KB891808_gene1407	7.771e-43	169.0	COG0726@1|root,COG0726@2|Bacteria,2GNFA@201174|Actinobacteria	201174|Actinobacteria	G	polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
REGS3_k127_1292201_8	105422.BBPM01000044_gene1767	9.729e-113	378.0	COG3391@1|root,COG3391@2|Bacteria,2GK45@201174|Actinobacteria,2NFH2@228398|Streptacidiphilus	201174|Actinobacteria	S	40-residue YVTN family beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
REGS3_k127_1292201_12	1123320.KB889685_gene2253	1.858e-93	311.0	COG0745@1|root,COG0745@2|Bacteria,2GJ2N@201174|Actinobacteria	201174|Actinobacteria	T	response regulator, receiver	kdpE	-	-	ko:K02483,ko:K07667	ko02020,ko02024,map02020,map02024	M00454	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
REGS3_k127_1292201_1	1229780.BN381_130211	2.634e-236	756.0	COG0642@1|root,COG2205@2|Bacteria,2HFQ8@201174|Actinobacteria,3UXJT@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
REGS3_k127_1292201_2	525909.Afer_1922	2.349e-189	619.0	COG0531@1|root,COG0531@2|Bacteria,2GK5V@201174|Actinobacteria,4CNMX@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
REGS3_k127_1292201_9	196162.Noca_1843	1.198e-104	355.0	COG2079@1|root,COG2079@2|Bacteria,2GKUR@201174|Actinobacteria,4DV93@85009|Propionibacteriales	201174|Actinobacteria	S	PFAM MmgE PrpD family protein	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
REGS3_k127_1292201_6	196162.Noca_1837	7.057e-125	420.0	COG0665@1|root,COG0665@2|Bacteria,2HNJI@201174|Actinobacteria	201174|Actinobacteria	E	FAD dependent oxidoreductase	-	-	1.4.99.6	ko:K19746	ko00472,ko01100,map00472,map01100	-	R11018	RC00006	ko00000,ko00001,ko01000	-	-	-	DAO
REGS3_k127_1292201_10	479431.Namu_3959	4.742e-104	348.0	COG0626@1|root,COG0626@2|Bacteria,2GMD8@201174|Actinobacteria,4ERG7@85013|Frankiales	201174|Actinobacteria	E	Cys/Met metabolism PLP-dependent enzyme	metB	-	2.5.1.48	ko:K01739	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00999,R01288,R02508,R03217,R03260,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00420,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
REGS3_k127_1292201_0	471852.Tcur_2667	0.0	1452.0	COG1643@1|root,COG1643@2|Bacteria,2GIWX@201174|Actinobacteria,4EGY7@85012|Streptosporangiales	201174|Actinobacteria	L	Helicase associated domain (HA2)  Add an annotation	hrpA	-	3.6.4.13	ko:K03578	-	-	-	-	ko00000,ko01000	-	-	-	AAA_19,DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind
REGS3_k127_1292201_11	468556.AQYG01000045_gene1822	1.979e-94	316.0	COG2326@1|root,COG2326@2|Bacteria,2GKRN@201174|Actinobacteria,4GA3R@85026|Gordoniaceae	201174|Actinobacteria	S	Polyphosphate kinase 2 (PPK2)	-	-	2.7.4.1	ko:K22468	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PPK2
REGS3_k127_1292201_5	1380390.JIAT01000009_gene991	7.682e-130	434.0	COG3794@1|root,COG3794@2|Bacteria,2HQ6D@201174|Actinobacteria,4CRPC@84995|Rubrobacteria	84995|Rubrobacteria	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_1292201_13	1313172.YM304_11080	1.16e-83	281.0	COG0315@1|root,COG0315@2|Bacteria,2IHR6@201174|Actinobacteria,4CMYS@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
REGS3_k127_1292201_7	1313172.YM304_11060	2.503e-120	396.0	2DB7V@1|root,2Z7NX@2|Bacteria,2I9CJ@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_1292201_3	1313172.YM304_11040	6.761e-166	526.0	COG2896@1|root,COG2896@2|Bacteria,2GN0V@201174|Actinobacteria,4CMV8@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Mob_synth_C,Radical_SAM
REGS3_k127_1292201_4	1313172.YM304_11030	1.619e-135	456.0	COG0303@1|root,COG0303@2|Bacteria,2GJC3@201174|Actinobacteria,4CMP8@84992|Acidimicrobiia	84992|Acidimicrobiia	H	MoeA N-terminal region (domain I and II)	moeA	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
REGS3_k127_1292201_18	1121377.KB906399_gene1871	1.126e-15	88.0	COG3554@1|root,COG3554@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K09957	-	-	-	-	ko00000	-	-	-	Glycolipid_bind
REGS3_k127_1292201_15	1192034.CAP_4028	9.11e-64	228.0	COG4912@1|root,COG4912@2|Bacteria,1QSBJ@1224|Proteobacteria,42QNI@68525|delta/epsilon subdivisions,2WN26@28221|Deltaproteobacteria,2YW3J@29|Myxococcales	28221|Deltaproteobacteria	L	DNA alkylation repair enzyme	-	-	-	-	-	-	-	-	-	-	-	-	DNA_alkylation
REGS3_k127_1292201_14	1313172.YM304_11010	6.949e-77	263.0	COG1210@1|root,COG1210@2|Bacteria,2I2EW@201174|Actinobacteria,4CMZE@84992|Acidimicrobiia	84992|Acidimicrobiia	M	Nucleotidyl transferase	-	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
REGS3_k127_1305615_0	1313172.YM304_08160	4.052e-233	723.0	COG0050@1|root,COG0050@2|Bacteria,2GK4T@201174|Actinobacteria,4CMSE@84992|Acidimicrobiia	84992|Acidimicrobiia	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
REGS3_k127_1305615_17	1313172.YM304_08170	2.589e-56	197.0	COG0051@1|root,COG0051@2|Bacteria,2IHRA@201174|Actinobacteria,4CN6W@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Involved in the binding of tRNA to the ribosomes	rpsJ	-	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
REGS3_k127_1305615_11	1313172.YM304_08190	1.333e-82	288.0	COG0265@1|root,COG0265@2|Bacteria,2GJ96@201174|Actinobacteria,4CN3Q@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Domain present in PSD-95, Dlg, and ZO-1/2.	-	-	-	ko:K08372	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Trypsin_2
REGS3_k127_1305615_5	1313172.YM304_08190	6.928e-101	342.0	COG0265@1|root,COG0265@2|Bacteria,2GJ96@201174|Actinobacteria,4CN3Q@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Domain present in PSD-95, Dlg, and ZO-1/2.	-	-	-	ko:K08372	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Trypsin_2
REGS3_k127_1305615_7	1313172.YM304_27130	7.596e-94	314.0	COG5285@1|root,COG5285@2|Bacteria,2IF9U@201174|Actinobacteria	201174|Actinobacteria	Q	Phytanoyl-CoA dioxygenase (PhyH)	-	-	-	-	-	-	-	-	-	-	-	-	PhyH
REGS3_k127_1305615_18	443255.SCLAV_p1168	1.579e-52	198.0	COG0500@1|root,COG2226@2|Bacteria,2I3AK@201174|Actinobacteria	201174|Actinobacteria	Q	Tellurite resistance protein TehB	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
REGS3_k127_1305615_25	1283299.AUKG01000002_gene4051	4.002e-27	123.0	COG0607@1|root,COG0607@2|Bacteria,2IKTC@201174|Actinobacteria,4CQJC@84995|Rubrobacteria	84995|Rubrobacteria	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
REGS3_k127_1305615_3	1254432.SCE1572_18520	3.861e-144	467.0	COG2267@1|root,COG2267@2|Bacteria,1QZUV@1224|Proteobacteria	1224|Proteobacteria	I	carboxylic ester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_1305615_4	314254.OA2633_01539	6.258e-103	342.0	COG1024@1|root,COG1024@2|Bacteria,1NDT7@1224|Proteobacteria,2U2R9@28211|Alphaproteobacteria,43XFU@69657|Hyphomonadaceae	28211|Alphaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
REGS3_k127_1305615_27	463191.SSEG_03426	1.457e-08	65.0	COG0265@1|root,COG1286@1|root,COG0265@2|Bacteria,COG1286@2|Bacteria,2GJ92@201174|Actinobacteria	201174|Actinobacteria	O	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain	cvpA	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0009268,GO:0009405,GO:0009628,GO:0010447,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044419,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051704,GO:0071944	-	-	-	-	-	-	-	-	-	-	Colicin_V,Trypsin_2
REGS3_k127_1305615_6	1313172.YM304_08250	2.488e-94	319.0	COG0087@1|root,COG0087@2|Bacteria,2GJXT@201174|Actinobacteria,4CMZP@84992|Acidimicrobiia	84992|Acidimicrobiia	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
REGS3_k127_1305615_10	1313172.YM304_08260	1.48e-84	287.0	COG0088@1|root,COG0088@2|Bacteria,2GJYJ@201174|Actinobacteria,4CN29@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Forms part of the polypeptide exit tunnel	rplD	-	-	ko:K02926	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
REGS3_k127_1305615_20	1313172.YM304_08270	6.802e-39	147.0	COG0089@1|root,COG0089@2|Bacteria,2IQ7V@201174|Actinobacteria,4CN84@84992|Acidimicrobiia	84992|Acidimicrobiia	J	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome	rplW	-	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
REGS3_k127_1305615_1	1313172.YM304_08280	3.084e-153	489.0	COG0090@1|root,COG0090@2|Bacteria,2GK7R@201174|Actinobacteria,4CMT8@84992|Acidimicrobiia	84992|Acidimicrobiia	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	-	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
REGS3_k127_1305615_19	1121877.JQKF01000009_gene544	2.847e-47	174.0	COG0185@1|root,COG0185@2|Bacteria,2IKMS@201174|Actinobacteria,4CN5R@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rpsS	-	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
REGS3_k127_1305615_16	1313172.YM304_08300	3.588e-59	213.0	COG0091@1|root,COG0091@2|Bacteria,2IM3J@201174|Actinobacteria,4CNBP@84992|Acidimicrobiia	84992|Acidimicrobiia	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rplV	-	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
REGS3_k127_1305615_2	1313172.YM304_08310	1.513e-145	468.0	COG0092@1|root,COG0092@2|Bacteria,2GKF1@201174|Actinobacteria,4CMU9@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	-	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
REGS3_k127_1305615_12	1313172.YM304_08320	2.224e-74	251.0	COG0197@1|root,COG0197@2|Bacteria,2IFEI@201174|Actinobacteria,4CN0S@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs	rplP	-	-	ko:K02878	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
REGS3_k127_1305615_26	1313172.YM304_08330	5.764e-20	95.0	COG0255@1|root,COG0255@2|Bacteria	2|Bacteria	J	Belongs to the universal ribosomal protein uL29 family	rpmC	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
REGS3_k127_1305615_23	1313172.YM304_08340	3.196e-32	129.0	COG0186@1|root,COG0186@2|Bacteria,2IQ68@201174|Actinobacteria,4CN9S@84992|Acidimicrobiia	84992|Acidimicrobiia	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rpsQ	-	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
REGS3_k127_1305615_14	1313172.YM304_08350	6.829e-67	233.0	COG0093@1|root,COG0093@2|Bacteria,2IHNX@201174|Actinobacteria,4CMZN@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rplN	-	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
REGS3_k127_1305615_21	1313172.YM304_08360	2.466e-35	137.0	COG0198@1|root,COG0198@2|Bacteria,2HGDN@201174|Actinobacteria,4CNBW@84992|Acidimicrobiia	84992|Acidimicrobiia	J	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit	rplX	-	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,ribosomal_L24
REGS3_k127_1305615_8	1313172.YM304_08370	5.803e-88	295.0	COG0094@1|root,COG0094@2|Bacteria,2GJW7@201174|Actinobacteria,4CMX7@84992|Acidimicrobiia	84992|Acidimicrobiia	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rplE	-	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
REGS3_k127_1305615_24	1313172.YM304_08380	2.081e-27	111.0	COG0199@1|root,COG0199@2|Bacteria,2IQ8R@201174|Actinobacteria,4CNZU@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site	rpsN	-	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
REGS3_k127_1305615_15	1313172.YM304_08390	4.27e-66	227.0	COG0096@1|root,COG0096@2|Bacteria,2IHQZ@201174|Actinobacteria,4CN3X@84992|Acidimicrobiia	84992|Acidimicrobiia	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rpsH	-	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
REGS3_k127_1305615_13	1313172.YM304_08400	1.112e-69	241.0	COG0097@1|root,COG0097@2|Bacteria,2GK35@201174|Actinobacteria,4CMZ3@84992|Acidimicrobiia	84992|Acidimicrobiia	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rplF	-	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
REGS3_k127_1305615_22	388467.A19Y_0435	2.694e-33	132.0	COG0256@1|root,COG0256@2|Bacteria,1G6MX@1117|Cyanobacteria,1HBHE@1150|Oscillatoriales	1117|Cyanobacteria	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rplR	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008097,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18p
REGS3_k127_1305615_9	1313172.YM304_08420	7.849e-86	287.0	COG0098@1|root,COG0098@2|Bacteria,2GJW8@201174|Actinobacteria,4CN34@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body	rpsE	-	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
REGS3_k127_1318257_0	1313172.YM304_23290	0.0	1706.0	COG0508@1|root,COG0567@1|root,COG0508@2|Bacteria,COG0567@2|Bacteria,2GIU6@201174|Actinobacteria,4CMWS@84992|Acidimicrobiia	84992|Acidimicrobiia	C	2-oxoglutarate dehydrogenase N-terminus	-	-	1.2.4.2	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
REGS3_k127_1318257_1	1313172.YM304_23310	5.033e-80	280.0	COG1011@1|root,COG1011@2|Bacteria,2IN1K@201174|Actinobacteria	201174|Actinobacteria	S	HAD-superfamily hydrolase subfamily IA, variant 3	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2,Hydrolase
REGS3_k127_1318257_2	1313172.YM304_23320	2.701e-77	269.0	COG0539@1|root,COG0539@2|Bacteria,2I7V9@201174|Actinobacteria	201174|Actinobacteria	J	Zc3h12a-like Ribonuclease NYN domain	-	-	-	-	-	-	-	-	-	-	-	-	HC2,RNase_Zc3h12a
REGS3_k127_1336925_7	1288079.AUKN01000007_gene1863	6.386e-06	53.0	COG5343@1|root,COG5343@2|Bacteria,2I8NI@201174|Actinobacteria	201174|Actinobacteria	K	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigK. ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut extracytoplasmically (site-1 protease, S1P), then within the membrane itself (site-2 protease, S2P, Rip1), while cytoplasmic proteases finish degrading the regulatory protein, liberating the sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	RskA,zf-HC2
REGS3_k127_1336925_2	864069.MicloDRAFT_00035210	7.492e-58	207.0	COG0454@1|root,COG0456@2|Bacteria,1RBE6@1224|Proteobacteria,2U9H8@28211|Alphaproteobacteria,1JV5V@119045|Methylobacteriaceae	28211|Alphaproteobacteria	K	Acetyltransferase (GNAT) domain	ttr	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
REGS3_k127_1336925_6	350058.Mvan_0507	3.892e-11	69.0	COG3462@1|root,COG3462@2|Bacteria,2GRGM@201174|Actinobacteria,23F4M@1762|Mycobacteriaceae	201174|Actinobacteria	S	Short C-terminal domain	-	-	-	ko:K08982	-	-	-	-	ko00000	-	-	-	SHOCT
REGS3_k127_1336925_5	469383.Cwoe_0386	6.955e-26	113.0	COG1695@1|root,COG1695@2|Bacteria	2|Bacteria	K	negative regulation of transcription, DNA-templated	-	-	-	ko:K10917	ko02024,ko05111,map02024,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	PadR
REGS3_k127_1336925_3	298654.FraEuI1c_3649	1.043e-53	196.0	COG0229@1|root,COG0229@2|Bacteria,2IHV0@201174|Actinobacteria,4ESRX@85013|Frankiales	201174|Actinobacteria	O	PFAM Methionine sulfoxide reductase B	msrB	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
REGS3_k127_1336925_0	1120950.KB892750_gene6871	8.609e-103	346.0	COG3842@1|root,COG3842@2|Bacteria,2H2JF@201174|Actinobacteria,4DPFC@85009|Propionibacteriales	201174|Actinobacteria	P	TOBE domain	modC	-	3.6.3.29	ko:K02017,ko:K02018	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.8	-	-	ABC_tran,TOBE
REGS3_k127_1336925_1	463191.SSEG_09046	6.072e-74	259.0	COG4149@1|root,COG4149@2|Bacteria,2GJFB@201174|Actinobacteria	201174|Actinobacteria	P	Molybdate ABC transporter	modB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.6.3.29	ko:K02017,ko:K02018	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.8	-	-	ABC_tran,BPD_transp_1,TOBE
REGS3_k127_1336925_4	1123258.AQXZ01000018_gene1249	1.658e-36	143.0	COG0725@1|root,COG0725@2|Bacteria,2GMPF@201174|Actinobacteria,4FU1U@85025|Nocardiaceae	201174|Actinobacteria	P	Bacterial extracellular solute-binding protein	modA	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0008150,GO:0030288,GO:0030313,GO:0030973,GO:0031975,GO:0040007,GO:0042597,GO:0043167,GO:0043168,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0051704	-	ko:K02020	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	SBP_bac_11
REGS3_k127_13448_6	1313172.YM304_29420	8.299e-56	202.0	COG1051@1|root,COG1051@2|Bacteria	2|Bacteria	F	GDP-mannose mannosyl hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
REGS3_k127_13448_7	1125971.ASJB01000080_gene7213	7.653e-51	207.0	COG1404@1|root,COG1472@1|root,COG3828@1|root,COG4932@1|root,COG1404@2|Bacteria,COG1472@2|Bacteria,COG3828@2|Bacteria,COG4932@2|Bacteria,2I4SB@201174|Actinobacteria,4EE04@85010|Pseudonocardiales	201174|Actinobacteria	GMO	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080,PKD,Peptidase_S8,Ricin_B_lectin
REGS3_k127_13448_8	287986.DV20_40585	3.105e-45	175.0	COG2764@1|root,COG3324@1|root,COG2764@2|Bacteria,COG3324@2|Bacteria,2GMZD@201174|Actinobacteria,4E3SB@85010|Pseudonocardiales	201174|Actinobacteria	S	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	ko:K04750	-	-	-	-	ko00000	-	-	-	Glyoxalase
REGS3_k127_13448_0	882086.SacxiDRAFT_1507	0.0	1309.0	COG0587@1|root,COG0587@2|Bacteria,2GJ1P@201174|Actinobacteria,4DYKC@85010|Pseudonocardiales	201174|Actinobacteria	L	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase	dnaE2	GO:0000731,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0018130,GO:0019438,GO:0019985,GO:0030312,GO:0031668,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0042276,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0046483,GO:0046677,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:1901360,GO:1901362,GO:1901576	2.7.7.7	ko:K14162	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
REGS3_k127_13448_9	1313172.YM304_29340	5.543e-42	164.0	COG1051@1|root,COG1051@2|Bacteria	2|Bacteria	F	GDP-mannose mannosyl hydrolase activity	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DUF4743,NUDIX
REGS3_k127_13448_16	1133849.O3I_035275	2.04e-16	89.0	COG2331@1|root,COG2331@2|Bacteria,2GR6C@201174|Actinobacteria,4G48R@85025|Nocardiaceae	201174|Actinobacteria	S	Regulatory protein, FmdB family	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
REGS3_k127_13448_2	1089455.MOPEL_135_01480	3.622e-136	447.0	COG0281@1|root,COG0281@2|Bacteria,2GJAJ@201174|Actinobacteria,4F6CB@85018|Dermatophilaceae	201174|Actinobacteria	C	Malic enzyme, NAD binding domain	-	-	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	-	R00214	RC00105	ko00000,ko00001,ko01000	-	-	-	ACT,ACT_4,Malic_M,malic
REGS3_k127_13448_14	1313172.YM304_29250	1.405e-25	114.0	COG4339@1|root,COG4339@2|Bacteria,2HH0H@201174|Actinobacteria,4CP0S@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Protein of unknown function (DUF4031)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4031
REGS3_k127_13448_5	339670.Bamb_3987	2.556e-58	204.0	COG1917@1|root,COG1917@2|Bacteria,1RDGQ@1224|Proteobacteria,2W2TG@28216|Betaproteobacteria	28216|Betaproteobacteria	H	Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant	-	-	4.2.1.108	ko:K06720	ko00260,ko01100,ko01120,map00260,map01100,map01120	M00033	R06979	RC01729	ko00000,ko00001,ko00002,ko01000	-	-	-	Ectoine_synth
REGS3_k127_13448_1	339670.Bamb_3988	1.137e-138	454.0	COG0154@1|root,COG0154@2|Bacteria,1MU51@1224|Proteobacteria,2VJN4@28216|Betaproteobacteria,1K1B5@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Belongs to the amidase family	-	-	3.5.1.4,6.3.5.6,6.3.5.7	ko:K01426,ko:K02433	ko00330,ko00360,ko00380,ko00627,ko00643,ko00970,ko01100,ko01120,map00330,map00360,map00380,map00627,map00643,map00970,map01100,map01120	-	R02540,R03096,R03180,R03905,R03909,R04212,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
REGS3_k127_13448_13	1313172.YM304_29220	6.063e-32	127.0	COG1393@1|root,COG1393@2|Bacteria	2|Bacteria	P	arsenate reductase (glutaredoxin) activity	arsC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	1.20.4.1	ko:K00537	-	-	-	-	ko00000,ko01000	-	-	-	ArsC
REGS3_k127_13448_3	1229780.BN381_10292	2.286e-125	416.0	COG1960@1|root,COG1960@2|Bacteria,2GJDT@201174|Actinobacteria	201174|Actinobacteria	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
REGS3_k127_13448_17	2002.JOEQ01000009_gene6585	4.211e-11	70.0	2BUVA@1|root,32Q74@2|Bacteria,2HE2M@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_13448_10	134676.ACPL_4771	5.009e-38	151.0	COG4276@1|root,COG4276@2|Bacteria,2HEMM@201174|Actinobacteria,4DKTT@85008|Micromonosporales	201174|Actinobacteria	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
REGS3_k127_13448_12	1313172.YM304_19670	1.445e-32	128.0	COG2261@1|root,COG2261@2|Bacteria	2|Bacteria	S	Transglycosylase associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
REGS3_k127_13448_4	1313172.YM304_29210	2.459e-88	301.0	COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4CNI7@84992|Acidimicrobiia	84992|Acidimicrobiia	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
REGS3_k127_1421447_3	511.JT27_11115	3.138e-06	50.0	COG1385@1|root,COG1385@2|Bacteria,1MXCU@1224|Proteobacteria,2VJS2@28216|Betaproteobacteria,3T31U@506|Alcaligenaceae	28216|Betaproteobacteria	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	rsmE	-	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
REGS3_k127_1421447_2	1313172.YM304_21140	3.133e-67	232.0	COG1396@1|root,COG1396@2|Bacteria,2I569@201174|Actinobacteria,4CN5U@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
REGS3_k127_1421447_0	1313172.YM304_21150	4.732e-145	469.0	COG0635@1|root,COG0635@2|Bacteria,2GJXX@201174|Actinobacteria,4CNTM@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
REGS3_k127_1421447_1	1246995.AFR_02925	9.733e-70	243.0	COG2119@1|root,COG2119@2|Bacteria,2GNR0@201174|Actinobacteria,4D8J9@85008|Micromonosporales	201174|Actinobacteria	S	Uncharacterized protein family UPF0016	-	-	-	-	-	-	-	-	-	-	-	-	UPF0016
REGS3_k127_1439343_5	1313172.YM304_25000	9.037e-67	239.0	COG0128@1|root,COG0128@2|Bacteria,2GJKX@201174|Actinobacteria,4CNB2@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
REGS3_k127_1439343_1	1313172.YM304_24990	7.989e-129	421.0	COG0287@1|root,COG0287@2|Bacteria,2GKB4@201174|Actinobacteria,4CNBS@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Prephenate dehydrogenase	-	-	1.3.1.12	ko:K00210,ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025	R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	PDH
REGS3_k127_1439343_3	1313172.YM304_24980	4.67e-98	334.0	COG1187@1|root,COG1187@2|Bacteria,2GJ4N@201174|Actinobacteria,4CN36@84992|Acidimicrobiia	84992|Acidimicrobiia	J	RNA pseudouridylate synthase	rluB	-	5.4.99.22	ko:K06178	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
REGS3_k127_1439343_4	1313172.YM304_24970	4.372e-72	256.0	COG1386@1|root,COG1386@2|Bacteria,2GISY@201174|Actinobacteria,4CN9J@84992|Acidimicrobiia	84992|Acidimicrobiia	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves	-	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
REGS3_k127_1439343_2	1313172.YM304_24960	2.743e-110	361.0	COG1354@1|root,COG1354@2|Bacteria,2GN1U@201174|Actinobacteria	201174|Actinobacteria	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	scpA	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
REGS3_k127_1439343_0	1313172.YM304_24950	3.797e-146	469.0	COG0180@1|root,COG0180@2|Bacteria,2GJ9A@201174|Actinobacteria,4CMTD@84992|Acidimicrobiia	84992|Acidimicrobiia	J	tRNA synthetases class I (W and Y)	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
REGS3_k127_1439343_6	1313172.YM304_24920	3.084e-41	153.0	COG4974@1|root,COG4974@2|Bacteria,2GNDP@201174|Actinobacteria,4CMZU@84992|Acidimicrobiia	84992|Acidimicrobiia	D	Phage integrase, N-terminal SAM-like domain	xerC	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
REGS3_k127_144236_2	419947.MRA_1038	2.565e-109	356.0	COG2216@1|root,COG2216@2|Bacteria,2GIWT@201174|Actinobacteria,234VJ@1762|Mycobacteriaceae	201174|Actinobacteria	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system	kdpB	-	3.6.3.12	ko:K01547	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	-	E1-E2_ATPase,Hydrolase
REGS3_k127_144236_6	419947.MRA_1039	8.02e-61	217.0	COG2156@1|root,COG2156@2|Bacteria,2GK75@201174|Actinobacteria,232GY@1762|Mycobacteriaceae	201174|Actinobacteria	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex	kdpC	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044425,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132	3.6.3.12	ko:K01548	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	-	KdpC
REGS3_k127_144236_0	1157640.AQWO01000041_gene779	5.087e-238	766.0	COG0642@1|root,COG2205@2|Bacteria,2GJKC@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	kdpD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0016020,GO:0044424,GO:0044464,GO:0071944	2.7.13.3	ko:K07646	ko02020,map02020	M00454	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF4118,HATPase_c,HisKA,KdpD,Usp
REGS3_k127_144236_3	1123320.KB889685_gene2253	2.63e-80	274.0	COG0745@1|root,COG0745@2|Bacteria,2GJ2N@201174|Actinobacteria	201174|Actinobacteria	T	response regulator, receiver	kdpE	-	-	ko:K02483,ko:K07667	ko02020,ko02024,map02020,map02024	M00454	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
REGS3_k127_144236_1	1313172.YM304_15230	4.22e-180	567.0	COG2141@1|root,COG2141@2|Bacteria,2HG01@201174|Actinobacteria,4CNXD@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
REGS3_k127_144236_4	1229780.BN381_80217	6.588e-79	277.0	COG1946@1|root,COG1946@2|Bacteria	2|Bacteria	I	acyl-CoA hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	4HBT_3
REGS3_k127_144236_7	1449048.JQKU01000005_gene4583	1.04e-32	134.0	2CK29@1|root,33KY0@2|Bacteria,2IPTN@201174|Actinobacteria,23AIB@1762|Mycobacteriaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_144236_5	1313172.YM304_15220	3.965e-78	266.0	COG0154@1|root,COG0154@2|Bacteria,2GKPZ@201174|Actinobacteria	201174|Actinobacteria	J	Belongs to the amidase family	-	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
REGS3_k127_1459059_8	1054213.HMPREF9946_03715	3.164e-23	104.0	COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,2TRIQ@28211|Alphaproteobacteria,2JRKK@204441|Rhodospirillales	204441|Rhodospirillales	E	DegT/DnrJ/EryC1/StrS aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
REGS3_k127_1459059_4	316274.Haur_3900	2.954e-76	262.0	COG1216@1|root,COG1216@2|Bacteria,2GBIQ@200795|Chloroflexi,374ZU@32061|Chloroflexia	32061|Chloroflexia	S	PFAM glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
REGS3_k127_1459059_3	1313172.YM304_22430	8.88e-173	556.0	COG2124@1|root,COG2124@2|Bacteria,2GJ8V@201174|Actinobacteria	201174|Actinobacteria	Q	cytochrome p450	cyp279A2	-	-	-	-	-	-	-	-	-	-	-	p450
REGS3_k127_1459059_6	1229780.BN381_300018	1.531e-43	165.0	COG0454@1|root,COG0456@2|Bacteria,2I9Y3@201174|Actinobacteria,3UWY3@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_7
REGS3_k127_1459059_2	1313172.YM304_22440	7.615e-180	569.0	COG0686@1|root,COG0686@2|Bacteria,2GJ6G@201174|Actinobacteria,4CMQC@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Alanine dehydrogenase/PNT, N-terminal domain	ald	-	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
REGS3_k127_1459059_0	467200.ACFA01000276_gene1229	1.317e-239	748.0	COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria	201174|Actinobacteria	C	Belongs to the aldehyde dehydrogenase family	prr1	-	1.2.1.8	ko:K00130	ko00260,ko01100,map00260,map01100	M00555	R02565,R02566	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
REGS3_k127_1459059_7	1306990.BARG01000024_gene2337	4.217e-42	169.0	COG4420@1|root,COG4420@2|Bacteria,2INCC@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF1003)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1003
REGS3_k127_1459059_5	1155718.KB891962_gene229	6.333e-53	194.0	COG4291@1|root,COG4291@2|Bacteria,2GIW8@201174|Actinobacteria	201174|Actinobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF1345
REGS3_k127_1459059_1	525909.Afer_0575	5.442e-191	608.0	COG0161@1|root,COG0161@2|Bacteria,2GKF6@201174|Actinobacteria,4CNF6@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Aminotransferase class-III	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_3
REGS3_k127_1459059_9	222534.KB893670_gene3658	4.337e-05	46.0	COG1522@1|root,COG1522@2|Bacteria,2GP1P@201174|Actinobacteria,4ESI6@85013|Frankiales	201174|Actinobacteria	K	PFAM regulatory protein AsnC Lrp family	-	-	-	ko:K03718	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
REGS3_k127_1563666_2	1313172.YM304_14970	1.061e-10	62.0	COG0164@1|root,COG0164@2|Bacteria,2GJFN@201174|Actinobacteria,4CN9Z@84992|Acidimicrobiia	84992|Acidimicrobiia	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	-	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
REGS3_k127_1563666_1	1229780.BN381_10099	3.516e-163	522.0	COG0626@1|root,COG0626@2|Bacteria,2GJ5S@201174|Actinobacteria,3UX4H@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	E	Cys/Met metabolism PLP-dependent enzyme	metB	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003962,GO:0004123,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006534,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009070,GO:0009086,GO:0009092,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0017144,GO:0019279,GO:0019343,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071265,GO:0071266,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.5.1.48	ko:K01739	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00999,R01288,R02508,R03217,R03260,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00420,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1079	Cys_Met_Meta_PP
REGS3_k127_1563666_0	1313172.YM304_15010	9.934e-225	704.0	COG0031@1|root,COG3620@1|root,COG0031@2|Bacteria,COG3620@2|Bacteria,2GIXE@201174|Actinobacteria,4CMZT@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Pyridoxal-phosphate dependent enzyme	-	-	2.5.1.47,4.2.1.22	ko:K01697,ko:K01738	ko00260,ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021,M00035,M00338	R00891,R00897,R01290,R03601,R04859,R04942	RC00020,RC00056,RC00069,RC00256,RC00489,RC01246,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
REGS3_k127_1577218_3	1121035.AUCH01000012_gene2970	3.939e-121	401.0	COG1092@1|root,COG1092@2|Bacteria,1MUGB@1224|Proteobacteria,2VKNG@28216|Betaproteobacteria,2KUS1@206389|Rhodocyclales	206389|Rhodocyclales	J	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase	-	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
REGS3_k127_1577218_5	1229780.BN381_150047	2.391e-64	222.0	COG0346@1|root,COG0346@2|Bacteria,2IIPR@201174|Actinobacteria,3UWVQ@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	E	Glyoxalase-like domain	mce	-	5.1.99.1	ko:K05606	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R02765,R09979	RC00780,RC02739	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase_4
REGS3_k127_1577218_0	1313172.YM304_37120	4.995e-232	723.0	COG0604@1|root,COG0604@2|Bacteria,2GKFF@201174|Actinobacteria,4CMSB@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Zinc-binding dehydrogenase	-	-	1.3.1.86	ko:K17829	ko00650,ko01120,ko01130,ko01200,map00650,map01120,map01130,map01200	-	R09738	RC00076	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
REGS3_k127_1577218_2	1313172.YM304_37130	1.206e-190	601.0	COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria,4CMTP@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Thiolase, C-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
REGS3_k127_1577218_4	1313172.YM304_37150	6.57e-100	329.0	COG0353@1|root,COG0353@2|Bacteria,2GJY0@201174|Actinobacteria,4CN1B@84992|Acidimicrobiia	84992|Acidimicrobiia	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	-	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecR,Toprim_4
REGS3_k127_1577218_1	1313172.YM304_37160	7.93e-196	630.0	COG2812@1|root,COG2812@2|Bacteria,2GJKA@201174|Actinobacteria,4CMQ5@84992|Acidimicrobiia	84992|Acidimicrobiia	H	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2
REGS3_k127_1577218_6	1313172.YM304_37180	7.478e-21	102.0	COG1276@1|root,COG2372@1|root,COG1276@2|Bacteria,COG2372@2|Bacteria	2|Bacteria	C	response to copper ion	-	-	-	ko:K07156,ko:K07245,ko:K14166	-	-	-	-	ko00000,ko02000	9.B.62.1,9.B.62.2	-	-	CopC,CopD
REGS3_k127_166916_8	349741.Amuc_1503	1.07e-08	62.0	COG1989@1|root,COG1989@2|Bacteria,46TWT@74201|Verrucomicrobia,2IU6Y@203494|Verrucomicrobiae	203494|Verrucomicrobiae	NOU	Type IV leader peptidase family	-	-	3.4.23.43	ko:K02654	-	M00331	-	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2	-	-	DiS_P_DiS,Peptidase_A24
REGS3_k127_166916_5	1242864.D187_005109	1.035e-69	253.0	COG0477@1|root,COG2814@2|Bacteria,1QRUM@1224|Proteobacteria,42MFJ@68525|delta/epsilon subdivisions,2X2AQ@28221|Deltaproteobacteria,2Z25Q@29|Myxococcales	28221|Deltaproteobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
REGS3_k127_166916_0	1313172.YM304_12820	4.134e-199	634.0	COG0624@1|root,COG0624@2|Bacteria,2GM84@201174|Actinobacteria,4CMU6@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
REGS3_k127_166916_3	1229780.BN381_10277	5.559e-123	402.0	COG2070@1|root,COG2070@2|Bacteria,2GKA6@201174|Actinobacteria,3UXGG@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	NMO
REGS3_k127_166916_1	1313172.YM304_15790	1.405e-167	535.0	COG0644@1|root,COG0644@2|Bacteria,2GMH9@201174|Actinobacteria	201174|Actinobacteria	C	geranylgeranyl reductase	-	-	1.3.99.38	ko:K21401	-	-	-	-	ko00000,ko01000	-	-	-	FAD_binding_3
REGS3_k127_166916_6	1211815.CBYP010000034_gene2158	6.103e-61	219.0	COG5479@1|root,COG5479@2|Bacteria	2|Bacteria	M	isomerase activity	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_2,LGFP,Phospholip_A2_3
REGS3_k127_166916_2	1313172.YM304_15810	1.314e-140	454.0	COG1028@1|root,COG1028@2|Bacteria,2GJ1F@201174|Actinobacteria,4CMRY@84992|Acidimicrobiia	84992|Acidimicrobiia	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
REGS3_k127_166916_4	1313172.YM304_15820	1.03e-119	391.0	COG2030@1|root,COG2030@2|Bacteria,2GJJI@201174|Actinobacteria	201174|Actinobacteria	I	dehydratase	htdY	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydrat_N,MaoC_dehydratas
REGS3_k127_166916_7	266940.Krad_3767	1.544e-16	83.0	COG1488@1|root,COG1488@2|Bacteria,2GJAT@201174|Actinobacteria	201174|Actinobacteria	H	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP	pncB	GO:0003674,GO:0003824,GO:0004516,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0016874,GO:0016879,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0019674,GO:0030312,GO:0034355,GO:0034641,GO:0034654,GO:0043094,GO:0043173,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044464,GO:0046483,GO:0046496,GO:0047280,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	-	NAPRTase,QRPTase_C
REGS3_k127_1723440_4	298655.KI912267_gene7915	4.044e-06	51.0	COG3631@1|root,COG3631@2|Bacteria,2ISRH@201174|Actinobacteria	201174|Actinobacteria	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
REGS3_k127_1723440_3	298655.KI912267_gene7914	2.616e-52	193.0	COG0346@1|root,COG0346@2|Bacteria,2IJX2@201174|Actinobacteria,4EVM1@85013|Frankiales	201174|Actinobacteria	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
REGS3_k127_1723440_2	1123269.NX02_08435	1.215e-68	236.0	COG3324@1|root,COG3324@2|Bacteria,1RBHJ@1224|Proteobacteria,2U6F9@28211|Alphaproteobacteria,2K4CP@204457|Sphingomonadales	204457|Sphingomonadales	S	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_1723440_0	1313172.YM304_42040	1.502e-153	501.0	COG0402@1|root,COG0402@2|Bacteria,2I9BJ@201174|Actinobacteria,4CN7U@84992|Acidimicrobiia	201174|Actinobacteria	F	Amidohydrolase family	-	-	3.5.4.28,3.5.4.31	ko:K12960	ko00270,ko01100,map00270,map01100	-	R09660	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
REGS3_k127_1723440_1	1313172.YM304_42280	1.237e-114	379.0	COG4638@1|root,COG4638@2|Bacteria,2IC5G@201174|Actinobacteria	201174|Actinobacteria	P	Rieske 2Fe-2S	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
REGS3_k127_1741469_3	1313172.YM304_18330	3.445e-111	377.0	COG0285@1|root,COG0285@2|Bacteria,2GJP2@201174|Actinobacteria,4CNAR@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Mur ligase middle domain	-	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_M
REGS3_k127_1741469_0	105420.BBPO01000038_gene397	1.583e-210	661.0	COG1219@1|root,COG1219@2|Bacteria,2GJXQ@201174|Actinobacteria,2NG8A@228398|Streptacidiphilus	201174|Actinobacteria	O	ClpX C4-type zinc finger	clpX	GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030312,GO:0030554,GO:0031333,GO:0032271,GO:0032272,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0043254,GO:0044087,GO:0044238,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051301,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
REGS3_k127_1741469_4	1313172.YM304_18310	3.699e-102	336.0	COG0740@1|root,COG0740@2|Bacteria,2GKNK@201174|Actinobacteria,4CMUY@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	-	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
REGS3_k127_1741469_1	1313172.YM304_18300	5.056e-168	544.0	COG0544@1|root,COG0544@2|Bacteria,2GJIG@201174|Actinobacteria,4CN55@84992|Acidimicrobiia	84992|Acidimicrobiia	D	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	-	-	ko:K03545	-	-	-	-	ko00000	-	-	-	Trigger_C,Trigger_N
REGS3_k127_1741469_5	452652.KSE_38680	2.998e-85	287.0	COG2197@1|root,COG2197@2|Bacteria,2GK4B@201174|Actinobacteria,2M0D1@2063|Kitasatospora	201174|Actinobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
REGS3_k127_1741469_6	1313172.YM304_28460	2.215e-57	213.0	COG4585@1|root,COG4585@2|Bacteria,2I312@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HATPase_c_2,HisKA_3
REGS3_k127_1741469_2	1313172.YM304_28400	6.327e-118	394.0	COG2132@1|root,COG4454@1|root,COG2132@2|Bacteria,COG4454@2|Bacteria,2GMJ4@201174|Actinobacteria	201174|Actinobacteria	Q	Multicopper oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase_2,Cu-oxidase_3,Cupredoxin_1
REGS3_k127_1741469_8	1121355.KB903379_gene745	3.259e-05	46.0	COG0544@1|root,COG0544@2|Bacteria,2GJIG@201174|Actinobacteria,22JV9@1653|Corynebacteriaceae	201174|Actinobacteria	D	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042221,GO:0042594,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0071496,GO:0071944	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
REGS3_k127_1747515_2	1313172.YM304_14950	4.623e-118	387.0	COG0240@1|root,COG0240@2|Bacteria,2GJSD@201174|Actinobacteria	201174|Actinobacteria	I	Glycerol-3-phosphate dehydrogenase	gpsA	-	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
REGS3_k127_1747515_3	1434325.AZQN01000005_gene3576	1.277e-75	267.0	COG2334@1|root,COG2334@2|Bacteria,4NITA@976|Bacteroidetes,47M89@768503|Cytophagia	976|Bacteroidetes	S	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_1747515_4	1380390.JIAT01000009_gene1919	4.886e-59	216.0	2AV96@1|root,31M03@2|Bacteria,2HPQD@201174|Actinobacteria,4CR3C@84995|Rubrobacteria	84995|Rubrobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_1747515_0	1229780.BN381_130208	9.818e-213	679.0	COG2060@1|root,COG2060@2|Bacteria,2GK51@201174|Actinobacteria	201174|Actinobacteria	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane	kdpA	GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0030312,GO:0030955,GO:0031420,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043167,GO:0043169,GO:0043492,GO:0044464,GO:0046872,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132	3.6.3.12	ko:K01546	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	-	KdpA
REGS3_k127_1747515_1	1229780.BN381_130209	6.128e-209	662.0	COG2216@1|root,COG2216@2|Bacteria	2|Bacteria	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system	kdpB	-	3.6.3.12	ko:K01547	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	-	E1-E2_ATPase,Hydrolase
REGS3_k127_1775946_2	1304865.JAGF01000001_gene817	7.934e-102	346.0	COG1840@1|root,COG1840@2|Bacteria,2GJFH@201174|Actinobacteria	201174|Actinobacteria	P	COG1840 ABC-type Fe3 transport system, periplasmic component	-	-	-	ko:K02055	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	SBP_bac_6
REGS3_k127_1775946_4	511051.CSE_14430	1.713e-75	263.0	COG4132@1|root,COG4132@2|Bacteria	2|Bacteria	P	(ABC) transporter, permease	-	-	-	ko:K02054	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	BPD_transp_1
REGS3_k127_1775946_5	326426.Bbr_0155	1.825e-58	216.0	COG1177@1|root,COG1177@2|Bacteria,2GM0E@201174|Actinobacteria,4CZ2N@85004|Bifidobacteriales	201174|Actinobacteria	U	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02053	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	BPD_transp_1
REGS3_k127_1775946_1	29306.JOBE01000044_gene1204	1.706e-111	371.0	COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the ABC transporter superfamily	-	-	-	ko:K02052	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	ABC_tran,TOBE_2
REGS3_k127_1775946_3	1048339.KB913029_gene1556	6.94e-94	317.0	COG0596@1|root,COG0596@2|Bacteria,2I3PB@201174|Actinobacteria,4EXHN@85013|Frankiales	201174|Actinobacteria	S	Alpha/beta hydrolase family	-	-	3.1.1.24	ko:K01055	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00568	R02991	RC00825	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1
REGS3_k127_1775946_0	1120950.KB892747_gene3731	2.376e-138	448.0	COG1995@1|root,COG1995@2|Bacteria,2GRPG@201174|Actinobacteria,4DTQK@85009|Propionibacteriales	201174|Actinobacteria	H	Pyridoxal phosphate biosynthetic protein PdxA	pdxA	-	1.1.1.262,1.1.1.408,1.1.1.409	ko:K00097,ko:K22024	ko00750,ko01100,map00750,map01100	M00124	R05681,R05837,R07406	RC00089,RC00675,RC01475	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1357_C,DUF1537,PdxA
REGS3_k127_1775946_6	1356854.N007_18735	3.55e-05	46.0	COG3395@1|root,COG3395@2|Bacteria,1TPNP@1239|Firmicutes	1239|Firmicutes	S	Protein conserved in bacteria	-	-	2.7.1.219,2.7.1.220	ko:K22129	-	-	-	-	ko00000,ko01000	-	-	-	DUF1357_C,DUF1537
REGS3_k127_1808178_5	1120934.KB894419_gene2099	1.235e-86	298.0	COG0601@1|root,COG0601@2|Bacteria,2GJ2C@201174|Actinobacteria,4DXT5@85010|Pseudonocardiales	201174|Actinobacteria	P	ABC-type dipeptide oligopeptide nickel transport system, permease component	oppB	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
REGS3_k127_1808178_2	103733.JNYO01000012_gene2732	6.752e-128	430.0	COG0747@1|root,COG0747@2|Bacteria,2GJ9N@201174|Actinobacteria,4DZ3E@85010|Pseudonocardiales	201174|Actinobacteria	E	ABC-type dipeptide transport system, periplasmic component	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
REGS3_k127_1808178_3	1313172.YM304_21690	7.82e-108	361.0	COG0149@1|root,COG0149@2|Bacteria,2GJXZ@201174|Actinobacteria,4CMZ0@84992|Acidimicrobiia	84992|Acidimicrobiia	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	-	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
REGS3_k127_1808178_0	1313172.YM304_21680	4.683e-182	577.0	COG0126@1|root,COG0126@2|Bacteria,2GJC6@201174|Actinobacteria,4CMV0@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Phosphoglycerate kinase	pgk	-	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
REGS3_k127_1808178_1	1313172.YM304_21670	1.555e-163	521.0	COG0057@1|root,COG0057@2|Bacteria,2GJK4@201174|Actinobacteria,4CMQP@84992|Acidimicrobiia	84992|Acidimicrobiia	G	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain	-	-	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
REGS3_k127_1808178_4	1313172.YM304_21660	1.341e-91	310.0	COG1660@1|root,COG1660@2|Bacteria,2GMWB@201174|Actinobacteria,4CMXB@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Displays ATPase and GTPase activities	-	-	-	ko:K06958	-	-	-	-	ko00000,ko03019	-	-	-	ATP_bind_2
REGS3_k127_1808178_6	1313172.YM304_21650	9.392e-18	83.0	COG0500@1|root,COG2226@2|Bacteria,2HG5Z@201174|Actinobacteria,4CN2W@84992|Acidimicrobiia	84992|Acidimicrobiia	H	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
REGS3_k127_1823853_3	1313172.YM304_05030	1.346e-111	364.0	COG1051@1|root,COG1051@2|Bacteria,2HG6C@201174|Actinobacteria,4CN3B@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Hydrolase of X-linked nucleoside diphosphate N terminal	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX,Nudix_N
REGS3_k127_1823853_4	76869.PputGB1_3726	5.356e-103	350.0	COG1231@1|root,COG1231@2|Bacteria,1MUPQ@1224|Proteobacteria,1RZXR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	amine oxidase	pao	-	1.4.3.4	ko:K00274	ko00260,ko00330,ko00340,ko00350,ko00360,ko00380,ko00950,ko00982,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00260,map00330,map00340,map00350,map00360,map00380,map00950,map00982,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00135	R02173,R02382,R02529,R02532,R02613,R02908,R02919,R04025,R04300,R04674,R04890,R04893,R04894,R04907,R04908,R08346,R08347,R08348,R11354	RC00062,RC00160,RC00225,RC00676,RC00807,RC00808,RC01808,RC02226,RC02713	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
REGS3_k127_1823853_1	1313172.YM304_01570	4.747e-129	423.0	COG0402@1|root,COG0402@2|Bacteria,2ISY0@201174|Actinobacteria	201174|Actinobacteria	F	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
REGS3_k127_1823853_5	1313172.YM304_16100	2.285e-78	280.0	COG3858@1|root,COG3858@2|Bacteria,2HZ7I@201174|Actinobacteria	201174|Actinobacteria	S	Glycosyl hydrolases family 18	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_18
REGS3_k127_1823853_0	196162.Noca_1630	5.6e-148	476.0	COG2141@1|root,COG2141@2|Bacteria,2GNQ3@201174|Actinobacteria,4DT50@85009|Propionibacteriales	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	1.5.98.2	ko:K00320	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R04464	RC01607	ko00000,ko00001,ko00002,ko01000	-	-	-	Bac_luciferase
REGS3_k127_1823853_6	1386089.N865_10540	3.382e-14	85.0	COG1732@1|root,COG1732@2|Bacteria,2GJWY@201174|Actinobacteria,4FEGF@85021|Intrasporangiaceae	201174|Actinobacteria	M	Glycine betaine ABC transporter substrate-binding protein	-	-	-	ko:K05845	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	OpuAC
REGS3_k127_1823853_2	1313172.YM304_04620	3.475e-114	376.0	COG1131@1|root,COG1131@2|Bacteria,2GJDP@201174|Actinobacteria,4CNJC@84992|Acidimicrobiia	84992|Acidimicrobiia	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
REGS3_k127_1842333_20	1380390.JIAT01000010_gene3535	1.879e-27	113.0	COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,2GNCW@201174|Actinobacteria,4CPSG@84995|Rubrobacteria	84995|Rubrobacteria	E	FAD dependent oxidoreductase central domain	-	-	-	-	-	-	-	-	-	-	-	-	DAO,FAO_M,GCV_T,GCV_T_C
REGS3_k127_1842333_17	1283299.AUKG01000002_gene4309	1.381e-45	186.0	COG0510@1|root,COG0510@2|Bacteria,2IAJ7@201174|Actinobacteria,4CR72@84995|Rubrobacteria	84995|Rubrobacteria	M	Choline/ethanolamine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Choline_kinase
REGS3_k127_1842333_18	585531.HMPREF0063_12027	5.26e-44	169.0	COG0406@1|root,COG0406@2|Bacteria,2GNRS@201174|Actinobacteria,4DQ6Z@85009|Propionibacteriales	201174|Actinobacteria	G	Phosphoglycerate mutase family	gpm2	GO:0003674,GO:0003824,GO:0003993,GO:0005488,GO:0005515,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0042578,GO:0042802,GO:0042803,GO:0044237,GO:0046983	3.1.3.73	ko:K02226	ko00860,ko01100,map00860,map01100	M00122	R04594,R11173	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
REGS3_k127_1842333_21	1449353.JQMQ01000005_gene2717	3.573e-26	112.0	COG1186@1|root,COG1186@2|Bacteria,2IFEJ@201174|Actinobacteria,2NINB@228398|Streptacidiphilus	201174|Actinobacteria	J	RF-1 domain	yaeJ	-	-	ko:K15034	-	-	-	-	ko00000,ko03012	-	-	-	RF-1
REGS3_k127_1842333_15	1229780.BN381_420033	5.677e-49	182.0	COG4097@1|root,COG4097@2|Bacteria	2|Bacteria	P	nitric oxide dioxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Fer2,Ferric_reduct,NAD_binding_1
REGS3_k127_1842333_12	68219.JNXI01000010_gene5736	9e-54	200.0	COG1477@1|root,COG1477@2|Bacteria,2H74Y@201174|Actinobacteria	201174|Actinobacteria	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	-	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
REGS3_k127_1842333_14	1313172.YM304_35650	5.252e-52	186.0	COG0838@1|root,COG0838@2|Bacteria,2IFDT@201174|Actinobacteria	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	nuoA2	-	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
REGS3_k127_1842333_8	1313172.YM304_35640	3.135e-99	325.0	COG0377@1|root,COG0377@2|Bacteria,2GJXR@201174|Actinobacteria,4CMXA@84992|Acidimicrobiia	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoB	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
REGS3_k127_1842333_10	1313172.YM304_35630	3.112e-83	281.0	COG0852@1|root,COG0852@2|Bacteria,2GNVP@201174|Actinobacteria	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	nuoC2	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
REGS3_k127_1842333_3	1313172.YM304_35620	1.206e-229	717.0	COG0649@1|root,COG0649@2|Bacteria,2GKEZ@201174|Actinobacteria,4CMP9@84992|Acidimicrobiia	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
REGS3_k127_1842333_5	1313172.YM304_35610	3.495e-169	542.0	COG1005@1|root,COG1005@2|Bacteria,2GIVY@201174|Actinobacteria,4CMTV@84992|Acidimicrobiia	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	-	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
REGS3_k127_1842333_9	1313172.YM304_35600	2.493e-92	306.0	COG1143@1|root,COG1143@2|Bacteria,2GPSS@201174|Actinobacteria	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoI2	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4
REGS3_k127_1842333_16	1313172.YM304_35590	6.889e-49	180.0	COG0839@1|root,COG0839@2|Bacteria,2GJB7@201174|Actinobacteria	201174|Actinobacteria	C	Belongs to the complex I subunit 6 family	nuoJ2	-	1.6.5.3	ko:K00339,ko:K05578	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
REGS3_k127_1842333_19	1313172.YM304_35580	1.325e-40	151.0	COG0713@1|root,COG0713@2|Bacteria,2IKV7@201174|Actinobacteria	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204	1.6.5.3	ko:K00340,ko:K05576	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
REGS3_k127_1842333_1	1313172.YM304_35570	1.646e-265	835.0	COG1009@1|root,COG1009@2|Bacteria,2GIT4@201174|Actinobacteria,4CMPU@84992|Acidimicrobiia	201174|Actinobacteria	CP	protein synonym multiple resistance and pH homeostasis protein A	-	-	1.6.5.3	ko:K00341,ko:K05565	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko02000	2.A.63.1,2.A.63.2,3.D.1	-	-	DUF4040,Proton_antipo_M,Proton_antipo_N
REGS3_k127_1842333_2	1313172.YM304_35560	6.255e-234	739.0	COG1008@1|root,COG1008@2|Bacteria,2GKBN@201174|Actinobacteria,4CMUB@84992|Acidimicrobiia	201174|Actinobacteria	C	Protein synonym NADH dehydrogenase I subunit M	nuoM2	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
REGS3_k127_1842333_4	1313172.YM304_35550	9.632e-201	636.0	COG1007@1|root,COG1007@2|Bacteria,2GMGX@201174|Actinobacteria,4CMT6@84992|Acidimicrobiia	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN2	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
REGS3_k127_1842333_7	1313172.YM304_35500	4.605e-118	389.0	COG1565@1|root,COG1565@2|Bacteria	2|Bacteria	P	acr, cog1565	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_28
REGS3_k127_1842333_0	1313172.YM304_35460	0.0	1066.0	COG0365@1|root,COG0365@2|Bacteria,2GJCG@201174|Actinobacteria,4CMRX@84992|Acidimicrobiia	84992|Acidimicrobiia	I	AMP-binding enzyme C-terminal domain	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
REGS3_k127_1842333_11	1313172.YM304_35430	1.603e-68	236.0	COG1666@1|root,COG1666@2|Bacteria,2IFIU@201174|Actinobacteria,4CN1Y@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Protein of unknown function (DUF520)	-	-	-	ko:K09767	-	-	-	-	ko00000	-	-	-	DUF520
REGS3_k127_1842333_6	1121877.JQKF01000038_gene1818	1.267e-162	531.0	COG0488@1|root,COG0488@2|Bacteria,2GJ5M@201174|Actinobacteria,4CNGN@84992|Acidimicrobiia	84992|Acidimicrobiia	S	ATPases associated with a variety of cellular activities	-	-	-	ko:K15738	-	-	-	-	ko00000,ko02000	3.A.1.120.6	-	-	ABC_tran
REGS3_k127_1842333_13	1313172.YM304_07840	2.553e-53	192.0	COG1247@1|root,COG1247@2|Bacteria,2IHSY@201174|Actinobacteria,4CN6Q@84992|Acidimicrobiia	84992|Acidimicrobiia	M	Acetyltransferase (GNAT) domain	-	-	2.3.1.183	ko:K03823	ko00440,ko01130,map00440,map01130	-	R08871,R08938	RC00004,RC00064	ko00000,ko00001,ko01000	-	-	-	Acetyltransf_4
REGS3_k127_1842333_22	1313172.YM304_08160	4.526e-16	81.0	COG0050@1|root,COG0050@2|Bacteria,2GK4T@201174|Actinobacteria,4CMSE@84992|Acidimicrobiia	84992|Acidimicrobiia	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
REGS3_k127_1850256_13	1313172.YM304_03420	3.41e-46	176.0	COG0827@1|root,COG0827@2|Bacteria,2HGZ7@201174|Actinobacteria,4CNZE@84992|Acidimicrobiia	84992|Acidimicrobiia	L	N-6 DNA Methylase	-	-	-	-	-	-	-	-	-	-	-	-	N6_Mtase
REGS3_k127_1850256_4	1313172.YM304_03410	2.288e-145	467.0	COG1072@1|root,COG1072@2|Bacteria,2GIRR@201174|Actinobacteria	201174|Actinobacteria	H	(Pantothenic acid kinase))	coaA	GO:0003674,GO:0003824,GO:0004594,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.1.33	ko:K00867	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PRK
REGS3_k127_1850256_9	1313172.YM304_03330	4.974e-69	250.0	COG1011@1|root,COG1011@2|Bacteria,2GN3E@201174|Actinobacteria	201174|Actinobacteria	S	hydrolase	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2,Hydrolase
REGS3_k127_1850256_19	446462.Amir_4586	4.218e-21	107.0	COG1670@1|root,COG1670@2|Bacteria,2IIWF@201174|Actinobacteria,4E41X@85010|Pseudonocardiales	201174|Actinobacteria	J	Acetyltransferase (GNAT) domain	-	-	2.3.1.128,2.3.1.82	ko:K00663,ko:K03790	-	-	-	-	ko00000,ko01000,ko01504,ko03009	-	-	-	Acetyltransf_1,Acetyltransf_3
REGS3_k127_1850256_16	1313172.YM304_03320	3.228e-40	154.0	COG2964@1|root,COG2964@2|Bacteria,2IHSD@201174|Actinobacteria	201174|Actinobacteria	S	HTH domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_22
REGS3_k127_1850256_18	1167006.UWK_00957	2.568e-24	114.0	COG1443@1|root,COG1443@2|Bacteria,1P8AM@1224|Proteobacteria,42T9Z@68525|delta/epsilon subdivisions,2WP8K@28221|Deltaproteobacteria,2MM8R@213118|Desulfobacterales	28221|Deltaproteobacteria	I	NUDIX domain	-	-	5.3.3.2	ko:K01823	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00095,M00096,M00364,M00365,M00366,M00367	R01123	RC00455	ko00000,ko00001,ko00002,ko01000	-	-	-	NUDIX
REGS3_k127_1850256_2	298654.FraEuI1c_4763	1.684e-196	641.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4EU6F@85013|Frankiales	201174|Actinobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	6.2.1.41	ko:K00666,ko:K18687	ko00984,ko01100,ko01120,map00984,map01100,map01120	-	R10769	RC00004,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
REGS3_k127_1850256_11	1123320.KB889747_gene7183	8.372e-51	185.0	COG1545@1|root,COG3425@1|root,COG1545@2|Bacteria,COG3425@2|Bacteria,2GP7R@201174|Actinobacteria	201174|Actinobacteria	I	DUF35 OB-fold domain, acyl-CoA-associated	-	-	-	-	-	-	-	-	-	-	-	-	ACP_syn_III_C,DUF35_N,OB_aCoA_assoc
REGS3_k127_1850256_6	1123320.KB889747_gene7183	5.382e-114	374.0	COG1545@1|root,COG3425@1|root,COG1545@2|Bacteria,COG3425@2|Bacteria,2GP7R@201174|Actinobacteria	201174|Actinobacteria	I	DUF35 OB-fold domain, acyl-CoA-associated	-	-	-	-	-	-	-	-	-	-	-	-	ACP_syn_III_C,DUF35_N,OB_aCoA_assoc
REGS3_k127_1850256_1	479433.Caci_5352	4.075e-210	659.0	COG0183@1|root,COG0183@2|Bacteria,2GIY0@201174|Actinobacteria	201174|Actinobacteria	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
REGS3_k127_1850256_15	420324.KI912031_gene2787	1.533e-40	159.0	COG0295@1|root,COG0295@2|Bacteria,1MY2R@1224|Proteobacteria,2U9FW@28211|Alphaproteobacteria,1JV0P@119045|Methylobacteriaceae	28211|Alphaproteobacteria	F	This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis	cdd	-	3.5.4.5	ko:K01489	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01878,R02485,R08221	RC00074,RC00514	ko00000,ko00001,ko01000	-	-	-	dCMP_cyt_deam_1,dCMP_cyt_deam_2
REGS3_k127_1850256_3	981369.JQMJ01000003_gene7258	1.388e-155	499.0	COG0436@1|root,COG0436@2|Bacteria,2GJ7R@201174|Actinobacteria,2NF04@228398|Streptacidiphilus	201174|Actinobacteria	E	Cys/Met metabolism PLP-dependent enzyme	dapC	-	2.6.1.1,2.6.1.17	ko:K00812,ko:K14267	ko00220,ko00250,ko00270,ko00300,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00300,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01120,map01130,map01210,map01230	M00016	R00355,R00694,R00734,R00896,R02433,R02619,R04475,R05052	RC00006	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
REGS3_k127_1850256_7	1313172.YM304_02550	4.336e-106	355.0	COG0388@1|root,COG0388@2|Bacteria,2GMQA@201174|Actinobacteria	201174|Actinobacteria	E	Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
REGS3_k127_1850256_17	331869.BAL199_22122	2.394e-36	143.0	COG3818@1|root,COG3818@2|Bacteria,1RG7T@1224|Proteobacteria,2U8S8@28211|Alphaproteobacteria,4BSHP@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Acetyltransferase (GNAT) domain	-	-	-	ko:K06977	-	-	-	-	ko00000	-	-	-	Acetyltransf_1
REGS3_k127_1850256_5	356851.JOAN01000009_gene3050	6.484e-140	450.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria,4DAC8@85008|Micromonosporales	201174|Actinobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	nodI	-	-	ko:K09695	ko02010,map02010	M00252	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.102	-	-	ABC_tran
REGS3_k127_1850256_10	1313172.YM304_12800	3.576e-60	221.0	COG0842@1|root,COG0842@2|Bacteria,2GVC2@201174|Actinobacteria	201174|Actinobacteria	V	transport, permease protein	-	-	-	ko:K09694	ko02010,map02010	M00252	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.102	-	-	ABC2_membrane
REGS3_k127_1850256_8	1313172.YM304_12810	2.006e-94	329.0	COG0842@1|root,COG0842@2|Bacteria,2GMXR@201174|Actinobacteria	201174|Actinobacteria	V	transport, permease protein	-	-	-	ko:K09694	ko02010,map02010	M00252	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.102	-	-	ABC2_membrane
REGS3_k127_1850256_12	1095772.CAHH01000027_gene2535	6.586e-50	185.0	COG0546@1|root,COG0546@2|Bacteria,2HFGX@201174|Actinobacteria	201174|Actinobacteria	T	hydrolase	nt5e	GO:0003674,GO:0003824,GO:0004672,GO:0004713,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018108,GO:0018193,GO:0018212,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046777,GO:0071704,GO:0140096,GO:1901564	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
REGS3_k127_1850256_0	1313172.YM304_29070	5.43e-243	760.0	COG4108@1|root,COG4108@2|Bacteria,2GKQA@201174|Actinobacteria,4CNEX@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP	prfC	-	-	ko:K02837	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,RF3_C
REGS3_k127_1850256_14	1463926.JOCA01000021_gene6481	2.07e-45	172.0	COG1477@1|root,COG1477@2|Bacteria,2GN6F@201174|Actinobacteria	201174|Actinobacteria	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	apbE2	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
REGS3_k127_1857455_1	1229780.BN381_250066	5.594e-157	505.0	COG1960@1|root,COG1960@2|Bacteria,2GJDT@201174|Actinobacteria	201174|Actinobacteria	I	acyl-CoA dehydrogenase	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
REGS3_k127_1857455_3	1313172.YM304_29470	5.226e-46	171.0	2C1D9@1|root,2ZD16@2|Bacteria,2HBJG@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_1857455_4	1313172.YM304_29450	6.789e-35	143.0	COG4544@1|root,COG4544@2|Bacteria	2|Bacteria	L	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division	imuA	GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496	-	ko:K14160	-	-	-	-	ko00000,ko03400	-	-	-	-
REGS3_k127_1857455_0	1313172.YM304_29440	8.186e-166	537.0	COG0389@1|root,COG0389@2|Bacteria,2GMZ3@201174|Actinobacteria,4CN9B@84992|Acidimicrobiia	84992|Acidimicrobiia	L	Nucleotidyltransferase DNA polymerase involved in DNA repair	-	-	-	ko:K14161	-	-	-	-	ko00000,ko03400	-	-	-	-
REGS3_k127_1857455_2	1313172.YM304_29430	3.322e-79	273.0	COG0745@1|root,COG0745@2|Bacteria,2GJE6@201174|Actinobacteria	201174|Actinobacteria	T	Response regulator receiver	-	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
REGS3_k127_1875821_3	649831.L083_1845	5.274e-10	63.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	GT87,PMT_2
REGS3_k127_1875821_0	1463820.JOGW01000018_gene2261	7.137e-144	468.0	COG1228@1|root,COG1228@2|Bacteria,2GJH4@201174|Actinobacteria	201174|Actinobacteria	Q	Catalyzes the hydrolysis of 4-imidazolone-5-propionate to N-formimidoyl-L-glutamate, the third step in the histidine degradation pathway	hutI	-	3.5.2.7	ko:K01468	ko00340,ko01100,map00340,map01100	M00045	R02288	RC00683	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
REGS3_k127_1875821_1	246196.MSMEI_1150	1.826e-140	464.0	COG0402@1|root,COG0402@2|Bacteria,2GZ2Q@201174|Actinobacteria,23EX5@1762|Mycobacteriaceae	201174|Actinobacteria	F	Amidohydrolase family	hutF	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
REGS3_k127_1875821_2	1229780.BN381_130271	4.098e-47	170.0	COG0242@1|root,COG0242@2|Bacteria,2GNZ9@201174|Actinobacteria	201174|Actinobacteria	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0018193,GO:0018206,GO:0019538,GO:0031365,GO:0036211,GO:0042586,GO:0043170,GO:0043412,GO:0043686,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
REGS3_k127_1997516_2	479431.Namu_0800	3.065e-124	430.0	COG3127@1|root,COG3127@2|Bacteria,2H37M@201174|Actinobacteria,4ERZ6@85013|Frankiales	201174|Actinobacteria	Q	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
REGS3_k127_1997516_1	1172181.KB911699_gene1429	8.04e-135	461.0	COG3127@1|root,COG3127@2|Bacteria,2H37M@201174|Actinobacteria	201174|Actinobacteria	Q	ABC transporter (Permease)	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
REGS3_k127_1997516_3	1313172.YM304_34350	1.01e-115	376.0	COG1136@1|root,COG1136@2|Bacteria,2GJN6@201174|Actinobacteria,4CNT1@84992|Acidimicrobiia	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
REGS3_k127_1997516_0	1313172.YM304_34320	1.223e-259	839.0	COG0457@1|root,COG2114@1|root,COG3899@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG3899@2|Bacteria,2GJRI@201174|Actinobacteria	201174|Actinobacteria	T	Adenylyl cyclase class-3 4 guanylyl cyclase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Guanylate_cyc,TPR_12
REGS3_k127_1997516_6	1313172.YM304_34300	4.592e-20	94.0	COG2128@1|root,COG2128@2|Bacteria	2|Bacteria	S	hydroperoxide reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
REGS3_k127_1997516_9	1219035.NT2_01_01840	4.018e-13	73.0	COG2128@1|root,COG2128@2|Bacteria,1N56H@1224|Proteobacteria,2UABU@28211|Alphaproteobacteria,2K41Y@204457|Sphingomonadales	204457|Sphingomonadales	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
REGS3_k127_1997516_4	1313172.YM304_34270	1.732e-111	362.0	COG0450@1|root,COG0450@2|Bacteria,2GM74@201174|Actinobacteria,4CMXQ@84992|Acidimicrobiia	84992|Acidimicrobiia	O	C-terminal domain of 1-Cys peroxiredoxin	-	-	-	-	-	-	-	-	-	-	-	-	1-cysPrx_C,AhpC-TSA
REGS3_k127_1997516_5	313589.JNB_05585	5.086e-33	131.0	COG0640@1|root,COG0640@2|Bacteria,2GNW2@201174|Actinobacteria,4FJ3A@85021|Intrasporangiaceae	201174|Actinobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1,HTH_20
REGS3_k127_1997516_8	1298863.AUEP01000007_gene366	1.3e-13	77.0	COG3832@1|root,COG3832@2|Bacteria,2IMFE@201174|Actinobacteria,4DS84@85009|Propionibacteriales	201174|Actinobacteria	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
REGS3_k127_2015407_12	1089545.KB913037_gene8844	2.722e-06	53.0	COG3533@1|root,COG3533@2|Bacteria,2GM60@201174|Actinobacteria,4E1PQ@85010|Pseudonocardiales	201174|Actinobacteria	S	Beta-L-arabinofuranosidase, GH127	-	-	-	ko:K09955	-	-	-	-	ko00000	-	-	-	Glyco_hydro_127
REGS3_k127_2015407_13	1122132.AQYH01000001_gene865	0.0001233	46.0	COG3533@1|root,COG3533@2|Bacteria,1MWEN@1224|Proteobacteria,2U1Q4@28211|Alphaproteobacteria,4B9FZ@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Beta-L-arabinofuranosidase, GH127	-	-	-	ko:K09955	-	-	-	-	ko00000	-	-	-	Glyco_hydro_127
REGS3_k127_2015407_6	1107311.Q767_06900	7.996e-37	149.0	COG2890@1|root,COG2890@2|Bacteria,4NN9I@976|Bacteroidetes,1I1IS@117743|Flavobacteriia,2NW4Q@237|Flavobacterium	976|Bacteroidetes	J	Lysine methyltransferase	-	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS
REGS3_k127_2015407_4	298655.KI912266_gene4936	4.597e-43	169.0	COG0596@1|root,COG0596@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on ester bonds	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
REGS3_k127_2015407_9	694430.Natoc_0883	6.252e-13	79.0	COG0697@1|root,arCOG00271@2157|Archaea,2XT64@28890|Euryarchaeota,23TZT@183963|Halobacteria	183963|Halobacteria	G	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
REGS3_k127_2015407_8	1121877.JQKF01000027_gene2453	1.074e-19	91.0	2ANAN@1|root,31D8Y@2|Bacteria,2HGVW@201174|Actinobacteria,4CNX0@84992|Acidimicrobiia	84992|Acidimicrobiia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_2015407_1	1313172.YM304_23840	2.268e-195	615.0	COG2021@1|root,COG2021@2|Bacteria,2GKNJ@201174|Actinobacteria,4CNHB@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine	metX	-	2.3.1.31	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	-	R01776	RC00004,RC00041	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
REGS3_k127_2015407_3	161934.XP_010667926.1	1.152e-70	251.0	COG2513@1|root,KOG1260@2759|Eukaryota,37HN9@33090|Viridiplantae,3GD3G@35493|Streptophyta	35493|Streptophyta	C	Carboxyvinyl-carboxyphosphonate phosphorylmutase	-	-	-	-	-	-	-	-	-	-	-	-	PEP_mutase
REGS3_k127_2015407_0	450851.PHZ_c2065	3.357e-212	681.0	COG0318@1|root,COG0318@2|Bacteria,1MVJ1@1224|Proteobacteria,2TUQ9@28211|Alphaproteobacteria,2KIBE@204458|Caulobacterales	204458|Caulobacterales	IQ	AMP-binding enzyme C-terminal domain	-	-	6.2.1.42	ko:K18688	-	-	-	-	ko00000,ko01000	-	-	-	AMP-binding,AMP-binding_C
REGS3_k127_2015407_7	326427.Cagg_2624	2.8e-33	141.0	COG0739@1|root,COG1572@1|root,COG2133@1|root,COG0739@2|Bacteria,COG1572@2|Bacteria,COG2133@2|Bacteria,2G8ZC@200795|Chloroflexi,3759Y@32061|Chloroflexia	32061|Chloroflexia	GM	SMART Animal peptidoglycan recognition protein PGRP	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_2,PA14
REGS3_k127_2015407_5	926569.ANT_22220	4.401e-38	149.0	COG2940@1|root,COG2940@2|Bacteria,2G9DE@200795|Chloroflexi	200795|Chloroflexi	S	SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain	-	-	-	-	-	-	-	-	-	-	-	-	SET
REGS3_k127_2015407_2	469383.Cwoe_3295	4.507e-145	471.0	COG1748@1|root,COG1748@2|Bacteria,2GMQ1@201174|Actinobacteria	201174|Actinobacteria	E	Saccharopine dehydrogenase	lys1	-	1.5.1.7	ko:K00290	ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230	M00030,M00032	R00715	RC00217,RC01532	ko00000,ko00001,ko00002,ko01000	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP
REGS3_k127_2095769_15	1313172.YM304_25670	1.576e-56	201.0	COG0537@1|root,COG0537@2|Bacteria,2IKWU@201174|Actinobacteria	201174|Actinobacteria	FG	Histidine triad (Hit) protein	hit	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
REGS3_k127_2095769_19	1380390.JIAT01000005_gene5159	1.286e-44	173.0	COG1028@1|root,COG1028@2|Bacteria,2GIX2@201174|Actinobacteria,4CT8S@84995|Rubrobacteria	84995|Rubrobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
REGS3_k127_2095769_14	1313172.YM304_25680	4.896e-59	211.0	COG0558@1|root,COG0558@2|Bacteria,2GM3F@201174|Actinobacteria,4CN98@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.41	ko:K08744	ko00564,ko01100,map00564,map01100	-	R02030	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
REGS3_k127_2095769_1	1463864.JOGO01000084_gene5375	6.762e-243	777.0	COG1109@1|root,COG1208@1|root,COG1109@2|Bacteria,COG1208@2|Bacteria,2GKTE@201174|Actinobacteria	201174|Actinobacteria	JM	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B gamma epsilon subunits	-	-	2.7.7.13,5.4.2.8	ko:K16881	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114,M00362	R00885,R01818	RC00002,RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase,PGM_PMM_I,PGM_PMM_II,PGM_PMM_III
REGS3_k127_2095769_21	1313172.YM304_25690	1.524e-41	160.0	COG0509@1|root,COG0509@2|Bacteria,2IKN2@201174|Actinobacteria,4CN5F@84992|Acidimicrobiia	84992|Acidimicrobiia	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	-	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
REGS3_k127_2095769_10	1313172.YM304_25700	5.5e-67	233.0	COG1716@1|root,COG1716@2|Bacteria,2GK99@201174|Actinobacteria,4CN4F@84992|Acidimicrobiia	84992|Acidimicrobiia	T	Forkhead associated domain	-	-	-	-	-	-	-	-	-	-	-	-	Yop-YscD_cpl,zinc_ribbon_2
REGS3_k127_2095769_13	1313172.YM304_25710	1.59e-62	231.0	COG0789@1|root,COG0789@2|Bacteria,2HBV6@201174|Actinobacteria,4CN7E@84992|Acidimicrobiia	84992|Acidimicrobiia	K	helix_turn_helix, mercury resistance	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
REGS3_k127_2095769_18	1313172.YM304_25720	1.426e-49	182.0	COG1259@1|root,COG1259@2|Bacteria,2GN26@201174|Actinobacteria,4CN3Y@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Bifunctional nuclease	-	-	-	ko:K08999	-	-	-	-	ko00000	-	-	-	DNase-RNase
REGS3_k127_2095769_17	1229780.BN381_40086	1.679e-51	187.0	COG0789@1|root,COG0789@2|Bacteria,2GM67@201174|Actinobacteria,3UWPC@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	K	helix_turn_helix, mercury resistance	merR2	-	-	-	-	-	-	-	-	-	-	-	MerR_1
REGS3_k127_2095769_6	1313172.YM304_25740	2.563e-143	466.0	COG0404@1|root,COG0404@2|Bacteria,2GJ47@201174|Actinobacteria,4CMQS@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Glycine cleavage T-protein C-terminal barrel domain	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
REGS3_k127_2095769_0	1122611.KB903939_gene400	0.0	1162.0	COG0403@1|root,COG1003@1|root,COG0403@2|Bacteria,COG1003@2|Bacteria,2GJ11@201174|Actinobacteria,4EI8D@85012|Streptosporangiales	201174|Actinobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvP	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	1.4.4.2	ko:K00281,ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	GDC-P
REGS3_k127_2095769_20	1115632.JAFW01000001_gene4382	2.924e-42	162.0	COG3467@1|root,COG3467@2|Bacteria,2IP5U@201174|Actinobacteria,1W9TE@1268|Micrococcaceae	201174|Actinobacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Pyridox_ox_2
REGS3_k127_2095769_25	765910.MARPU_10005	1.884e-21	104.0	COG0589@1|root,COG0589@2|Bacteria,1NAHQ@1224|Proteobacteria	1224|Proteobacteria	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
REGS3_k127_2095769_3	1123320.KB889723_gene7516	3.152e-200	650.0	COG0474@1|root,COG0474@2|Bacteria,2GJJC@201174|Actinobacteria	201174|Actinobacteria	P	ATPase P-type (Transporting), HAD superfamily, subfamily IC	ctpE	GO:0003674,GO:0003824,GO:0005215,GO:0005388,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006816,GO:0008150,GO:0008324,GO:0015075,GO:0015085,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043492,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0070588,GO:0070838,GO:0071944,GO:0072511,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132	-	ko:K12952	-	-	-	-	ko00000,ko01000	3.A.3.23	-	-	E1-E2_ATPase,Hydrolase
REGS3_k127_2095769_2	1313172.YM304_25770	3.848e-209	655.0	COG2141@1|root,COG2141@2|Bacteria,2GITK@201174|Actinobacteria	201174|Actinobacteria	C	Monooxygenase	limB	-	1.14.13.107	ko:K14733	ko00903,map00903	-	R06398,R09385,R09389,R09393	RC01506	ko00000,ko00001,ko01000	-	-	-	Bac_luciferase
REGS3_k127_2095769_23	163908.KB235896_gene285	1.012e-28	119.0	29Z8H@1|root,30M6K@2|Bacteria,1GGGV@1117|Cyanobacteria	1117|Cyanobacteria	S	Protein of unknown function (DUF3237)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3237
REGS3_k127_2095769_4	589873.EP13_00335	1.055e-167	545.0	COG1063@1|root,COG1063@2|Bacteria,1MV9A@1224|Proteobacteria,1RMNY@1236|Gammaproteobacteria,464YH@72275|Alteromonadaceae	1236|Gammaproteobacteria	C	Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate	tdh	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006563,GO:0006564,GO:0006566,GO:0006567,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008270,GO:0008652,GO:0008743,GO:0009056,GO:0009058,GO:0009063,GO:0009066,GO:0009068,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0030145,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046395,GO:0046870,GO:0046872,GO:0046914,GO:0055114,GO:0071704,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607	1.1.1.103	ko:K00060	ko00260,map00260	-	R01465	RC00525	ko00000,ko00001,ko01000	-	-	iEC042_1314.EC042_3926,iECUMN_1333.ECUMN_4133,iPC815.YPO0060	ADH_N,ADH_zinc_N
REGS3_k127_2095769_5	1320556.AVBP01000018_gene2866	2.287e-162	522.0	COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,2TQYP@28211|Alphaproteobacteria,43H8Y@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	H	Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA	kbl	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008144,GO:0016874,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363	2.3.1.29	ko:K00639	ko00260,map00260	-	R00371	RC00004,RC00394	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
REGS3_k127_2095769_7	1242864.D187_006755	2.36e-119	396.0	COG0076@1|root,COG0076@2|Bacteria,1MX25@1224|Proteobacteria,42NCK@68525|delta/epsilon subdivisions,2WMCF@28221|Deltaproteobacteria,2YTU4@29|Myxococcales	28221|Deltaproteobacteria	E	Pyridoxal-dependent decarboxylase conserved domain	-	-	4.1.2.27	ko:K01634	ko00600,ko01100,ko04071,map00600,map01100,map04071	M00100	R02464,R06516	RC00264,RC00721,RC01266	ko00000,ko00001,ko00002,ko01000	-	-	-	Pyridoxal_deC
REGS3_k127_2095769_16	1313172.YM304_16600	3.881e-55	196.0	COG0545@1|root,COG0545@2|Bacteria,2IHQC@201174|Actinobacteria	201174|Actinobacteria	O	Peptidyl-prolyl cis-trans isomerase	fkbP	-	5.2.1.8	ko:K01802	-	-	-	-	ko00000,ko01000	-	-	-	FKBP_C
REGS3_k127_2095769_11	557599.MKAN_11100	6.023e-65	230.0	COG2141@1|root,COG2141@2|Bacteria,2GSSV@201174|Actinobacteria,23D2X@1762|Mycobacteriaceae	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
REGS3_k127_2095769_9	637390.AFOH01000117_gene2784	1.218e-98	334.0	COG0026@1|root,COG0026@2|Bacteria,1MU70@1224|Proteobacteria,1RQEI@1236|Gammaproteobacteria,2NBXD@225057|Acidithiobacillales	225057|Acidithiobacillales	F	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)	purK	-	6.3.4.18	ko:K01589	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07404	RC01927	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp
REGS3_k127_2095769_12	604331.AUHY01000036_gene34	1.775e-64	226.0	COG0041@1|root,COG0041@2|Bacteria,1WJ89@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
REGS3_k127_2095769_8	1229780.BN381_360022	4.861e-112	373.0	COG1680@1|root,COG1680@2|Bacteria,2HEWU@201174|Actinobacteria,3UXIA@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
REGS3_k127_2095769_24	118163.Ple7327_1614	1.114e-21	102.0	COG2159@1|root,COG2159@2|Bacteria,1G3DV@1117|Cyanobacteria,3VKKA@52604|Pleurocapsales	1117|Cyanobacteria	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
REGS3_k127_2128910_20	1206741.BAFX01000020_gene8141	9.756e-10	65.0	2EGCD@1|root,33A46@2|Bacteria,2GIVH@201174|Actinobacteria,4G2TU@85025|Nocardiaceae	201174|Actinobacteria	S	Domain of unknown function (DUF4190)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4190,Septum_form
REGS3_k127_2128910_15	1313172.YM304_09660	8.462e-40	153.0	COG3088@1|root,COG3088@2|Bacteria,2GTYU@201174|Actinobacteria	201174|Actinobacteria	P	subunit of a heme lyase	ccmH	-	-	ko:K02200	-	-	-	-	ko00000	-	-	-	CcmH
REGS3_k127_2128910_11	1313172.YM304_09650	1.334e-46	177.0	COG0526@1|root,COG0526@2|Bacteria	2|Bacteria	CO	cell redox homeostasis	-	-	-	ko:K02199	-	-	-	-	ko00000,ko03110	-	-	-	-
REGS3_k127_2128910_1	1313172.YM304_09640	1.208e-291	910.0	COG1138@1|root,COG1138@2|Bacteria,2HZM9@201174|Actinobacteria,4CMX6@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Cytochrome c-type biogenesis protein CcmF C-terminal	ccmF	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
REGS3_k127_2128910_14	1313172.YM304_09630	3.96e-43	164.0	COG2332@1|root,COG2332@2|Bacteria,2GZPB@201174|Actinobacteria,4CNCV@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH	ccmE	-	-	ko:K02197	-	-	-	-	ko00000	-	-	-	CcmE
REGS3_k127_2128910_5	1313172.YM304_09620	8.611e-91	305.0	COG0755@1|root,COG0755@2|Bacteria,2IIHK@201174|Actinobacteria,4CN1E@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Cytochrome C assembly protein	-	-	-	ko:K02195	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	Cytochrom_C_asm
REGS3_k127_2128910_7	1313172.YM304_09610	2.377e-87	295.0	COG2386@1|root,COG2386@2|Bacteria,2HG7F@201174|Actinobacteria,4CN4H@84992|Acidimicrobiia	84992|Acidimicrobiia	O	CcmB protein	-	-	-	ko:K02194	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	CcmB
REGS3_k127_2128910_6	1313172.YM304_09600	7.568e-90	305.0	COG1131@1|root,COG1131@2|Bacteria,2HG8W@201174|Actinobacteria,4CN6P@84992|Acidimicrobiia	84992|Acidimicrobiia	V	ATPases associated with a variety of cellular activities	-	-	3.6.3.41	ko:K02193	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.107	-	-	ABC_tran
REGS3_k127_2128910_16	351607.Acel_0016	3.081e-32	141.0	COG3764@1|root,COG3764@2|Bacteria,2GKT6@201174|Actinobacteria,4ESQZ@85013|Frankiales	201174|Actinobacteria	M	PFAM peptidase C60, sortase A and B	srtB	-	3.4.22.70	ko:K07284	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Sortase
REGS3_k127_2128910_9	1313172.YM304_09570	4.991e-81	282.0	COG1024@1|root,COG1024@2|Bacteria,2GJG7@201174|Actinobacteria	201174|Actinobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	echA6	GO:0003674,GO:0003824,GO:0004300,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016020,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0019395,GO:0019752,GO:0030258,GO:0030312,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0071944,GO:0072329,GO:1901575	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
REGS3_k127_2128910_8	1313172.YM304_09550	1.902e-81	281.0	COG1309@1|root,COG1309@2|Bacteria,2HGBF@201174|Actinobacteria,4CNA8@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
REGS3_k127_2128910_0	1313172.YM304_09490	0.0	2226.0	COG1201@1|root,COG1201@2|Bacteria,2I6VR@201174|Actinobacteria,4CNBF@84992|Acidimicrobiia	84992|Acidimicrobiia	L	DEAD-like helicases superfamily	-	-	-	ko:K03724,ko:K06877	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,Helicase_C
REGS3_k127_2128910_3	1313172.YM304_04550	3.093e-129	433.0	COG2146@1|root,COG2146@2|Bacteria,2GQWS@201174|Actinobacteria	201174|Actinobacteria	P	Rieske [2Fe-2S] domain	-	-	-	ko:K15762	ko00623,ko00920,ko01100,ko01120,ko01220,map00623,map00920,map01100,map01120,map01220	M00538	R02550,R03562,R05666,R09513	RC00269,RC00490,RC02556	ko00000,ko00001,ko00002	-	-	-	Rieske
REGS3_k127_2128910_2	1313172.YM304_09440	1.019e-216	695.0	COG1061@1|root,COG1061@2|Bacteria,2GIU5@201174|Actinobacteria	201174|Actinobacteria	L	type III restriction enzyme, res subunit	sdrA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	ResIII
REGS3_k127_2128910_12	471852.Tcur_3446	1.03e-45	175.0	2F0JC@1|root,33TN2@2|Bacteria,2GPGJ@201174|Actinobacteria,4EIVZ@85012|Streptosporangiales	201174|Actinobacteria	S	Mycothiol maleylpyruvate isomerase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_N
REGS3_k127_2128910_13	1115632.JAFW01000001_gene4358	1.66e-43	165.0	COG4978@1|root,COG4978@2|Bacteria,2IS9W@201174|Actinobacteria,1W9YZ@1268|Micrococcaceae	201174|Actinobacteria	KT	Bacterial transcription activator, effector binding domain	-	-	-	ko:K13652	-	-	-	-	ko00000,ko03000	-	-	-	GyrI-like,HTH_18
REGS3_k127_2128910_4	1313172.YM304_09420	8.882e-98	323.0	COG1321@1|root,COG1321@2|Bacteria,2GKMC@201174|Actinobacteria	201174|Actinobacteria	K	iron dependent repressor	ideR	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005506,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006355,GO:0006518,GO:0006725,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008198,GO:0008270,GO:0009058,GO:0009237,GO:0009712,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016020,GO:0016151,GO:0018958,GO:0019184,GO:0019219,GO:0019222,GO:0019290,GO:0019540,GO:0019748,GO:0030145,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0034641,GO:0040007,GO:0043043,GO:0043167,GO:0043169,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0044550,GO:0045892,GO:0045934,GO:0046870,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0050897,GO:0051171,GO:0051172,GO:0051186,GO:0051188,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,Fe_dep_repress,FeoA
REGS3_k127_2128910_17	1313172.YM304_09360	4.223e-27	112.0	COG3973@1|root,COG3973@2|Bacteria,2GK30@201174|Actinobacteria,4CMUM@84992|Acidimicrobiia	84992|Acidimicrobiia	L	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_19
REGS3_k127_2135009_5	1306174.JODP01000003_gene1783	1.12e-32	134.0	2DRIE@1|root,33BXS@2|Bacteria	2|Bacteria	S	Family of unknown function (DUF5317)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5317
REGS3_k127_2135009_0	2002.JOEQ01000012_gene5694	3.124e-140	471.0	COG5001@1|root,COG5001@2|Bacteria,2GIZF@201174|Actinobacteria,4EGRW@85012|Streptosporangiales	201174|Actinobacteria	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF
REGS3_k127_2135009_3	469383.Cwoe_0731	1.977e-50	196.0	COG1668@1|root,COG1668@2|Bacteria,2I9MY@201174|Actinobacteria	201174|Actinobacteria	CP	ABC-type Na efflux pump, permease	yhaP	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
REGS3_k127_2135009_1	1385519.N801_14525	1.528e-75	264.0	COG4152@1|root,COG4152@2|Bacteria,2I2DK@201174|Actinobacteria,4FEGG@85021|Intrasporangiaceae	201174|Actinobacteria	S	ABC transporter, ATP-binding protein	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
REGS3_k127_2135009_6	1172188.KB911824_gene3347	1.665e-22	99.0	2EC60@1|root,3364M@2|Bacteria,2GR61@201174|Actinobacteria,4FK1U@85021|Intrasporangiaceae	201174|Actinobacteria	S	2TM domain	-	-	-	-	-	-	-	-	-	-	-	-	2TM
REGS3_k127_2135009_4	196162.Noca_2898	1.827e-40	154.0	2DSM3@1|root,33GM1@2|Bacteria	2|Bacteria	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
REGS3_k127_2135009_2	471853.Bcav_1823	8.964e-65	227.0	COG0748@1|root,COG0748@2|Bacteria,2IP6Y@201174|Actinobacteria	201174|Actinobacteria	P	F420H(2)-dependent quinone reductase	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red
REGS3_k127_2135009_7	1211579.PP4_07490	0.0005	48.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,1RR5W@1236|Gammaproteobacteria,1YWTJ@136845|Pseudomonas putida group	1236|Gammaproteobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	AAA_16,GAF,GAF_2,HATPase_c,HisKA,MASE1,PAS_3,PAS_4,PAS_9,Pkinase
REGS3_k127_216763_5	749927.AMED_8359	1.244e-29	120.0	COG3945@1|root,COG3945@2|Bacteria,2I92G@201174|Actinobacteria,4EBBG@85010|Pseudonocardiales	201174|Actinobacteria	S	Pfam:DUF385	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red
REGS3_k127_216763_0	1144310.PMI07_004893	2.299e-197	633.0	COG2072@1|root,COG2072@2|Bacteria,1MWPJ@1224|Proteobacteria,2TSQA@28211|Alphaproteobacteria,4B9Z6@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	L-lysine 6-monooxygenase (NADPH-requiring)	-	-	-	ko:K07222	-	-	-	-	ko00000	-	-	-	Pyr_redox_3
REGS3_k127_216763_1	596151.DesfrDRAFT_1686	1.702e-128	426.0	COG1228@1|root,COG1228@2|Bacteria,1MUYR@1224|Proteobacteria,42NVH@68525|delta/epsilon subdivisions,2WJN9@28221|Deltaproteobacteria,2MAYM@213115|Desulfovibrionales	28221|Deltaproteobacteria	Q	Belongs to the metallo-dependent hydrolases superfamily. HutI family	hutI	-	3.5.2.7	ko:K01468	ko00340,ko01100,map00340,map01100	M00045	R02288	RC00683	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
REGS3_k127_216763_4	491952.Mar181_2524	2.91e-63	220.0	COG0251@1|root,COG0251@2|Bacteria,1RAKQ@1224|Proteobacteria,1S2FK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Endoribonuclease	yabJ_1	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
REGS3_k127_216763_3	1313172.YM304_38280	4.052e-96	329.0	COG1136@1|root,COG1136@2|Bacteria,2GJN6@201174|Actinobacteria,4CNT1@84992|Acidimicrobiia	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
REGS3_k127_216763_2	1313172.YM304_38290	1.206e-125	414.0	COG0577@1|root,COG0577@2|Bacteria,2GMC4@201174|Actinobacteria	201174|Actinobacteria	V	ABC-type antimicrobial peptide transport system, permease component	hrtB	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
REGS3_k127_216763_6	1313172.YM304_38300	1.171e-06	51.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
REGS3_k127_2184889_7	1380390.JIAT01000011_gene2542	3.57e-21	98.0	COG1595@1|root,COG1595@2|Bacteria,2HGII@201174|Actinobacteria,4CRQ5@84995|Rubrobacteria	84995|Rubrobacteria	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
REGS3_k127_2184889_9	1380390.JIAT01000011_gene2386	7.91e-06	55.0	2FDZX@1|root,34604@2|Bacteria,2IN56@201174|Actinobacteria,4CT9G@84995|Rubrobacteria	84995|Rubrobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_2184889_1	762948.HMPREF0733_10947	9.151e-90	321.0	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,2GMPZ@201174|Actinobacteria,1W7XS@1268|Micrococcaceae	201174|Actinobacteria	KLT	Protein tyrosine kinase	pknA	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
REGS3_k127_2184889_2	96561.Dole_1053	2.144e-56	203.0	COG2128@1|root,COG2128@2|Bacteria,1PSNE@1224|Proteobacteria,42XCT@68525|delta/epsilon subdivisions,2WSJD@28221|Deltaproteobacteria,2MP2A@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Carboxymuconolactone decarboxylase family	-	-	-	-	-	-	-	-	-	-	-	-	CMD
REGS3_k127_2184889_0	1041522.MCOL_V220266	1.095e-98	332.0	COG1028@1|root,COG1028@2|Bacteria,2IGF6@201174|Actinobacteria,23EVI@1762|Mycobacteriaceae	201174|Actinobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
REGS3_k127_2184889_3	215803.DB30_3714	1.176e-48	177.0	COG5485@1|root,COG5485@2|Bacteria,1RJSN@1224|Proteobacteria,434UF@68525|delta/epsilon subdivisions,2X911@28221|Deltaproteobacteria,2Z1D8@29|Myxococcales	28221|Deltaproteobacteria	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL
REGS3_k127_2184889_6	1121926.AXWO01000019_gene1910	2.053e-31	128.0	COG3427@1|root,COG3427@2|Bacteria,2ISBF@201174|Actinobacteria	201174|Actinobacteria	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
REGS3_k127_2184889_4	211114.JOEF01000017_gene3830	2.183e-43	165.0	COG1309@1|root,COG1309@2|Bacteria,2I9F9@201174|Actinobacteria,4E48X@85010|Pseudonocardiales	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
REGS3_k127_2184889_8	483216.BACEGG_01163	1.287e-07	57.0	2AN83@1|root,31D64@2|Bacteria,4NY2W@976|Bacteroidetes,2FVZV@200643|Bacteroidia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_2184889_5	797209.ZOD2009_10355	4.332e-37	145.0	arCOG13341@1|root,arCOG13341@2157|Archaea,2XXWE@28890|Euryarchaeota,23WKG@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_2200367_8	1108045.GORHZ_141_00240	5.576e-37	142.0	COG1073@1|root,COG1073@2|Bacteria,2I5P1@201174|Actinobacteria,4GFS1@85026|Gordoniaceae	201174|Actinobacteria	S	Dienelactone hydrolase family	-	-	-	ko:K07100	-	-	-	-	ko00000	-	-	-	DLH
REGS3_k127_2200367_7	2074.JNYD01000003_gene4041	1.266e-48	186.0	COG0500@1|root,COG2226@2|Bacteria,2IP4P@201174|Actinobacteria,4E5RD@85010|Pseudonocardiales	201174|Actinobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
REGS3_k127_2200367_3	1123024.AUII01000004_gene1695	9.513e-121	396.0	COG0106@1|root,COG0106@2|Bacteria,2GJ4V@201174|Actinobacteria,4DZTD@85010|Pseudonocardiales	201174|Actinobacteria	E	imidazole-4-carboxamide isomerase	hisA	GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.16,5.3.1.24	ko:K01814,ko:K01817	ko00340,ko00400,ko01100,ko01110,ko01130,ko01230,map00340,map00400,map01100,map01110,map01130,map01230	M00023,M00026	R03509,R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
REGS3_k127_2200367_5	1123024.AUII01000006_gene4591	6.014e-89	304.0	COG0583@1|root,COG0583@2|Bacteria,2I8WJ@201174|Actinobacteria,4E184@85010|Pseudonocardiales	201174|Actinobacteria	K	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
REGS3_k127_2200367_2	1121877.JQKF01000007_gene1026	7.92e-121	396.0	COG1319@1|root,COG1319@2|Bacteria,2GT14@201174|Actinobacteria,4CMQN@84992|Acidimicrobiia	201174|Actinobacteria	C	CO dehydrogenase flavoprotein C-terminal domain	-	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	iNJ661.Rv0375c	CO_deh_flav_C,FAD_binding_5
REGS3_k127_2200367_6	1121877.JQKF01000007_gene1025	2.731e-79	267.0	COG2080@1|root,COG2080@2|Bacteria,2GK8J@201174|Actinobacteria,4CN0J@84992|Acidimicrobiia	201174|Actinobacteria	C	[2Fe-2S] binding domain	coxS	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	iNJ661.Rv0374c	Fer2,Fer2_2
REGS3_k127_2200367_0	1121877.JQKF01000007_gene1024	0.0	1380.0	COG1529@1|root,COG1529@2|Bacteria,2GIVI@201174|Actinobacteria,4CMWW@84992|Acidimicrobiia	201174|Actinobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	coxL	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
REGS3_k127_2200367_4	1121877.JQKF01000007_gene1023	1.843e-90	310.0	COG1975@1|root,COG1975@2|Bacteria,2IA9U@201174|Actinobacteria	201174|Actinobacteria	O	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI,YHS
REGS3_k127_2200367_1	1121877.JQKF01000007_gene1022	4.927e-130	424.0	COG0714@1|root,COG0714@2|Bacteria,2GMM2@201174|Actinobacteria	201174|Actinobacteria	O	ATPase associated with various cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	AAA,AAA_5
REGS3_k127_2208745_13	667121.ET1_24_00500	6.385e-10	63.0	2DMTH@1|root,32TKP@2|Bacteria,1N4TE@1224|Proteobacteria,1S9K6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_2208745_1	1313172.YM304_19020	1.169e-168	550.0	COG0554@1|root,COG0554@2|Bacteria,2GM13@201174|Actinobacteria,4CMTY@84992|Acidimicrobiia	201174|Actinobacteria	F	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	-	-	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
REGS3_k127_2208745_2	1229780.BN381_170035	1.257e-151	496.0	COG0277@1|root,COG0277@2|Bacteria,2GIS6@201174|Actinobacteria	201174|Actinobacteria	C	FAD linked	-	-	2.5.1.26	ko:K00803	ko00565,ko01100,ko04146,map00565,map01100,map04146	-	R04311	RC00020,RC02886	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
REGS3_k127_2208745_0	1229780.BN381_170034	1.779e-181	585.0	COG0578@1|root,COG0578@2|Bacteria,2GJKN@201174|Actinobacteria,3UWFB@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family	-	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,DAO_C
REGS3_k127_2208745_8	1229780.BN381_170009	2.654e-38	149.0	COG0735@1|root,COG0735@2|Bacteria,2IFBR@201174|Actinobacteria,3UWZ1@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	P	Ferric uptake regulator family	catR	-	-	ko:K22297	-	-	-	-	ko00000,ko03000	-	-	-	FUR
REGS3_k127_2208745_5	2340.JV46_02710	1.407e-67	237.0	COG1592@1|root,COG1592@2|Bacteria,1R9WG@1224|Proteobacteria,1S25G@1236|Gammaproteobacteria,1J92R@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
REGS3_k127_2208745_3	1313172.YM304_19050	7.204e-150	489.0	COG0247@1|root,COG1149@1|root,COG0247@2|Bacteria,COG1149@2|Bacteria,2HGN8@201174|Actinobacteria,4CNP8@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Cysteine-rich domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG
REGS3_k127_2208745_6	1229780.BN381_170007	1.356e-57	208.0	COG0247@1|root,COG0247@2|Bacteria,2GVNV@201174|Actinobacteria	201174|Actinobacteria	C	Protein of unknown function (DUF3501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3501
REGS3_k127_2208745_9	1313172.YM304_19060	2.842e-27	113.0	2CC1Y@1|root,32YV9@2|Bacteria	2|Bacteria	K	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA	-	-	-	ko:K18955	-	-	-	-	ko00000,ko03000	-	-	-	Whib
REGS3_k127_2208745_4	1313172.YM304_19070	3.366e-132	431.0	COG0547@1|root,COG0547@2|Bacteria,2GM4G@201174|Actinobacteria,4CN1D@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	-	2.4.2.18	ko:K00766	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R01073	RC00440	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
REGS3_k127_2208745_7	1313172.YM304_19080	6.964e-55	203.0	COG0083@1|root,COG0083@2|Bacteria,2GKIW@201174|Actinobacteria,4CNCE@84992|Acidimicrobiia	84992|Acidimicrobiia	E	GHMP kinases N terminal domain	-	-	2.7.1.39	ko:K00872	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
REGS3_k127_2244351_20	1101188.KI912155_gene2566	3.853e-92	327.0	COG0726@1|root,COG1404@1|root,COG0726@2|Bacteria,COG1404@2|Bacteria,2GJYH@201174|Actinobacteria	201174|Actinobacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,Inhibitor_I9,PD40,Peptidase_S8,fn3
REGS3_k127_2244351_8	1313172.YM304_31590	8.058e-158	510.0	COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria,4CMSN@84992|Acidimicrobiia	201174|Actinobacteria	C	Aldehyde dehydrogenase family	calB	-	1.2.1.3,1.2.99.10	ko:K00128,ko:K22445	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
REGS3_k127_2244351_25	1313172.YM304_26360	9.503e-71	254.0	COG2334@1|root,COG2334@2|Bacteria	2|Bacteria	S	homoserine kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	APH
REGS3_k127_2244351_16	1313172.YM304_26370	7.305e-103	344.0	COG0277@1|root,COG0277@2|Bacteria,2H3K3@201174|Actinobacteria,4CNDA@84992|Acidimicrobiia	84992|Acidimicrobiia	C	FAD binding domain	-	-	-	ko:K11472	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	FAD_binding_4
REGS3_k127_2244351_3	1313172.YM304_26380	2.42e-198	630.0	COG0277@1|root,COG0277@2|Bacteria,2GJ2T@201174|Actinobacteria,4CMS1@84992|Acidimicrobiia	84992|Acidimicrobiia	C	FAD linked oxidases, C-terminal domain	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
REGS3_k127_2244351_2	1313172.YM304_26410	1.042e-198	628.0	COG2256@1|root,COG2256@2|Bacteria,2GKDP@201174|Actinobacteria,4CMYY@84992|Acidimicrobiia	84992|Acidimicrobiia	O	MgsA AAA+ ATPase C terminal	-	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA_assoc_2,MgsA_C,RuvB_N
REGS3_k127_2244351_30	1313172.YM304_26420	2.086e-51	187.0	COG0494@1|root,COG0494@2|Bacteria	2|Bacteria	L	nUDIX hydrolase	nudH	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009893,GO:0009894,GO:0009896,GO:0009987,GO:0010468,GO:0010604,GO:0010605,GO:0010608,GO:0010629,GO:0016070,GO:0016071,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0019219,GO:0019222,GO:0019439,GO:0031323,GO:0031325,GO:0031329,GO:0031331,GO:0033554,GO:0034353,GO:0034641,GO:0034655,GO:0043167,GO:0043169,GO:0043170,GO:0043487,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0045935,GO:0046483,GO:0046700,GO:0046872,GO:0048518,GO:0048519,GO:0048522,GO:0050779,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:1901360,GO:1901361,GO:1901575	-	ko:K08311	ko03018,map03018	-	R10816	RC00002	ko00000,ko00001,ko01000,ko03019	-	-	-	NUDIX
REGS3_k127_2244351_1	1313172.YM304_19980	1.423e-289	897.0	COG0173@1|root,COG0173@2|Bacteria,2GJHU@201174|Actinobacteria,4CMU8@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
REGS3_k127_2244351_4	1313172.YM304_19970	6.349e-184	584.0	COG0124@1|root,COG0124@2|Bacteria,2GIYJ@201174|Actinobacteria,4CNBR@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Histidyl-tRNA synthetase	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_His
REGS3_k127_2244351_0	1313172.YM304_19960	0.0	1071.0	COG0317@1|root,COG0317@2|Bacteria,2GJYQ@201174|Actinobacteria,4CMVH@84992|Acidimicrobiia	84992|Acidimicrobiia	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
REGS3_k127_2244351_24	1313172.YM304_19950	1.091e-72	248.0	COG0503@1|root,COG0503@2|Bacteria,2IM7C@201174|Actinobacteria	201174|Actinobacteria	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	apt	GO:0003674,GO:0003824,GO:0003999,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006144,GO:0006168,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009113,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0034641,GO:0034654,GO:0042440,GO:0043094,GO:0043096,GO:0043101,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044464,GO:0046083,GO:0046084,GO:0046112,GO:0046148,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
REGS3_k127_2244351_18	1313172.YM304_19940	3.042e-100	340.0	COG0341@1|root,COG0341@2|Bacteria,2GJRS@201174|Actinobacteria,4CMYT@84992|Acidimicrobiia	84992|Acidimicrobiia	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	-	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
REGS3_k127_2244351_15	1313172.YM304_19930	6.753e-109	372.0	COG0342@1|root,COG0342@2|Bacteria,2GJTT@201174|Actinobacteria,4CMXX@84992|Acidimicrobiia	84992|Acidimicrobiia	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF
REGS3_k127_2244351_35	1313172.YM304_19920	8.476e-24	105.0	COG1862@1|root,COG1862@2|Bacteria,2GXK0@201174|Actinobacteria	201174|Actinobacteria	U	Preprotein translocase subunit YajC	yajC	-	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
REGS3_k127_2244351_5	1313172.YM304_19910	1.623e-182	580.0	COG0343@1|root,COG0343@2|Bacteria,2GMWY@201174|Actinobacteria,4CMQI@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
REGS3_k127_2244351_13	1313172.YM304_19900	2.51e-128	418.0	COG0809@1|root,COG0809@2|Bacteria,2GN51@201174|Actinobacteria,4CMRE@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	queA	-	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
REGS3_k127_2244351_27	1068980.ARVW01000001_gene2769	1.539e-63	226.0	COG0412@1|root,COG0412@2|Bacteria,2IG4Y@201174|Actinobacteria,4E2ZB@85010|Pseudonocardiales	201174|Actinobacteria	Q	Dienelactone hydrolase family	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
REGS3_k127_2244351_7	1313172.YM304_19880	3.984e-162	516.0	COG2255@1|root,COG2255@2|Bacteria,2GJZF@201174|Actinobacteria,4CMVN@84992|Acidimicrobiia	84992|Acidimicrobiia	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
REGS3_k127_2244351_31	1229780.BN381_50109	5.722e-44	172.0	COG0632@1|root,COG0632@2|Bacteria,2GN17@201174|Actinobacteria,3UWUJ@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB	ruvA	GO:0000724,GO:0000725,GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007154,GO:0008150,GO:0008152,GO:0009378,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0031668,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0071103,GO:0071496,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:1901360	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
REGS3_k127_2244351_28	1313172.YM304_19860	1.792e-62	220.0	COG0817@1|root,COG0817@2|Bacteria,2GJI5@201174|Actinobacteria,4CNAX@84992|Acidimicrobiia	84992|Acidimicrobiia	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group	ruvC	-	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
REGS3_k127_2244351_9	1464048.JNZS01000007_gene4453	5.617e-156	515.0	2DBGS@1|root,2Z95N@2|Bacteria,2ICPX@201174|Actinobacteria,4DAIQ@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_2244351_26	1313172.YM304_19850	1.036e-64	228.0	COG1225@1|root,COG1225@2|Bacteria,2IJVV@201174|Actinobacteria,4CN6R@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Redoxin	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
REGS3_k127_2244351_17	1313172.YM304_19840	1.679e-100	333.0	COG0217@1|root,COG0217@2|Bacteria,2GJ4G@201174|Actinobacteria,4CMY7@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
REGS3_k127_2244351_23	1313172.YM304_19830	1.042e-72	249.0	COG0311@1|root,COG0311@2|Bacteria,2GNYG@201174|Actinobacteria,4CN52@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS	pdxT	-	4.3.3.6	ko:K08681	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SNO
REGS3_k127_2244351_6	1313172.YM304_19820	5.552e-165	522.0	COG0214@1|root,COG0214@2|Bacteria,2GK1T@201174|Actinobacteria,4CMSX@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively	pdxS	-	4.3.3.6	ko:K06215	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SOR_SNZ
REGS3_k127_2244351_29	1313172.YM304_19810	1.482e-59	220.0	COG1470@1|root,COG1470@2|Bacteria,2GP8D@201174|Actinobacteria,4CN8S@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Protein of unknown function (DUF3048) C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3048,DUF3048_C
REGS3_k127_2244351_10	1313172.YM304_19800	5.506e-147	470.0	COG0501@1|root,COG0501@2|Bacteria,2GMJF@201174|Actinobacteria,4CNA7@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Peptidase family M48	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
REGS3_k127_2244351_22	1313172.YM304_19790	8.79e-83	278.0	COG1704@1|root,COG1704@2|Bacteria,2GPS4@201174|Actinobacteria	201174|Actinobacteria	J	LemA family	lemA	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
REGS3_k127_2244351_12	1313172.YM304_19780	6.7e-132	439.0	COG0438@1|root,COG0438@2|Bacteria,2GKQ8@201174|Actinobacteria,4CN3N@84992|Acidimicrobiia	84992|Acidimicrobiia	M	Glycosyl transferases group 1	-	-	2.4.1.345	ko:K08256	-	-	R11702	-	ko00000,ko01000,ko01003	-	GT4	-	Glyco_trans_1_4,Glyco_transf_4
REGS3_k127_2244351_19	1313172.YM304_06500	2.043e-99	334.0	COG2141@1|root,COG2141@2|Bacteria,2H89R@201174|Actinobacteria	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
REGS3_k127_2244351_21	1313172.YM304_25660	1.037e-83	292.0	COG2135@1|root,COG2135@2|Bacteria,2HGDR@201174|Actinobacteria,4CNC9@84992|Acidimicrobiia	84992|Acidimicrobiia	S	SOS response associated peptidase (SRAP)	-	-	-	-	-	-	-	-	-	-	-	-	SRAP
REGS3_k127_2244351_11	1380356.JNIK01000015_gene2577	1.882e-135	442.0	COG2159@1|root,COG2159@2|Bacteria,2GMRC@201174|Actinobacteria,4EUW9@85013|Frankiales	201174|Actinobacteria	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
REGS3_k127_2244351_14	931627.MycrhDRAFT_2193	9.686e-111	365.0	COG2159@1|root,COG2159@2|Bacteria,2HSH2@201174|Actinobacteria,236WQ@1762|Mycobacteriaceae	201174|Actinobacteria	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
REGS3_k127_2287079_11	1133849.O3I_011040	1.31e-14	78.0	COG0454@1|root,COG0456@2|Bacteria,2GQGN@201174|Actinobacteria,4G2X3@85025|Nocardiaceae	201174|Actinobacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
REGS3_k127_2287079_10	67352.JODS01000009_gene7415	9.661e-15	85.0	COG4188@1|root,COG4188@2|Bacteria,2GJVV@201174|Actinobacteria	201174|Actinobacteria	M	Platelet-activating factor acetylhydrolase, plasma intracellular isoform II	-	-	-	-	-	-	-	-	-	-	-	-	PAF-AH_p_II
REGS3_k127_2287079_3	1313172.YM304_34960	6.626e-99	338.0	COG1316@1|root,COG1316@2|Bacteria,2GJJJ@201174|Actinobacteria,4CP53@84992|Acidimicrobiia	201174|Actinobacteria	K	Cell envelope-related transcriptional attenuator domain	-	-	-	-	-	-	-	-	-	-	-	-	LytR_C,LytR_cpsA_psr
REGS3_k127_2287079_4	1313172.YM304_34960	5.402e-96	331.0	COG1316@1|root,COG1316@2|Bacteria,2GJJJ@201174|Actinobacteria,4CP53@84992|Acidimicrobiia	201174|Actinobacteria	K	Cell envelope-related transcriptional attenuator domain	-	-	-	-	-	-	-	-	-	-	-	-	LytR_C,LytR_cpsA_psr
REGS3_k127_2287079_8	1454010.JEOE01000011_gene2420	5.087e-44	172.0	COG0668@1|root,COG0668@2|Bacteria,2GMFK@201174|Actinobacteria,4F0J8@85016|Cellulomonadaceae	201174|Actinobacteria	M	PFAM MscS Mechanosensitive ion channel	mscS	-	-	ko:K22044	-	-	-	-	ko00000,ko02000	1.A.23.3	-	-	MS_channel
REGS3_k127_2287079_0	471852.Tcur_1701	0.0	1176.0	COG0525@1|root,COG0525@2|Bacteria,2GK8H@201174|Actinobacteria,4EIDQ@85012|Streptosporangiales	201174|Actinobacteria	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
REGS3_k127_2287079_9	1313172.YM304_35060	1.483e-42	162.0	COG1648@1|root,COG1648@2|Bacteria,2GTES@201174|Actinobacteria	201174|Actinobacteria	H	TIGRFAM siroheme synthase	-	-	1.3.1.76,4.99.1.4	ko:K02304	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03947	RC01012,RC01034	ko00000,ko00001,ko00002,ko01000	-	-	-	CysG_dimeriser,NAD_binding_7,Sirohm_synth_M
REGS3_k127_2287079_6	1229780.BN381_180013	2.451e-77	265.0	COG0175@1|root,COG0175@2|Bacteria,2GJ3Z@201174|Actinobacteria,3UXF7@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	EH	Phosphoadenosine phosphosulfate reductase family	cysH	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004604,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016667,GO:0016671,GO:0019344,GO:0019752,GO:0040007,GO:0043436,GO:0043866,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.8.4.10,1.8.4.8	ko:K00390	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R02021	RC00007,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2392	PAPS_reduct
REGS3_k127_2287079_2	1123320.KB889563_gene6522	7.065e-124	403.0	COG0175@1|root,COG0175@2|Bacteria,2GN85@201174|Actinobacteria	201174|Actinobacteria	EH	sulfate adenylyltransferase	cysD	GO:0000103,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0006950,GO:0006979,GO:0007154,GO:0008150,GO:0008152,GO:0009267,GO:0009336,GO:0009605,GO:0009987,GO:0009991,GO:0010134,GO:0010438,GO:0019419,GO:0031667,GO:0031668,GO:0031669,GO:0032991,GO:0033554,GO:0034599,GO:0040007,GO:0042221,GO:0042594,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0061695,GO:0070887,GO:0071496,GO:1902494,GO:1902503,GO:1990234	2.7.7.4	ko:K00957	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	PAPS_reduct
REGS3_k127_2287079_1	1075090.GOAMR_20_01210	5.195e-125	415.0	COG0529@1|root,COG2895@1|root,COG0529@2|Bacteria,COG2895@2|Bacteria,2GJDX@201174|Actinobacteria,4GAAD@85026|Gordoniaceae	201174|Actinobacteria	H	Catalyzes the synthesis of activated sulfate	cysN	GO:0000103,GO:0003674,GO:0003824,GO:0004020,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006790,GO:0006793,GO:0006796,GO:0006950,GO:0006979,GO:0007154,GO:0008150,GO:0008152,GO:0009267,GO:0009336,GO:0009605,GO:0009987,GO:0009991,GO:0010134,GO:0010438,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019419,GO:0031667,GO:0031668,GO:0031669,GO:0032991,GO:0033554,GO:0034599,GO:0040007,GO:0042221,GO:0042594,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0061695,GO:0070887,GO:0071496,GO:0071944,GO:1902494,GO:1902503,GO:1990234	2.7.1.25,2.7.7.4	ko:K00955,ko:K00956	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00509,R00529,R04928,R04929	RC00002,RC00078,RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase,GTP_EFTU
REGS3_k127_2287079_5	1313172.YM304_35090	2.135e-80	276.0	COG0007@1|root,COG0007@2|Bacteria,2GK3B@201174|Actinobacteria,4CMZM@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Tetrapyrrole (Corrin/Porphyrin) Methylases	-	-	2.1.1.107,4.2.1.75	ko:K02303,ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165,R03194	RC00003,RC00871,RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4,TP_methylase
REGS3_k127_2287079_7	1313172.YM304_34860	1.565e-67	232.0	COG0215@1|root,COG0215@2|Bacteria,2GJF2@201174|Actinobacteria,4CMTW@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e
REGS3_k127_2293475_2	931277.C448_11771	1.482e-05	52.0	arCOG05861@1|root,arCOG05861@2157|Archaea,2Y1P5@28890|Euryarchaeota,23Y77@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M73
REGS3_k127_2293475_0	1229780.BN381_80336	0.0	1230.0	COG0209@1|root,COG0209@2|Bacteria,2GKX9@201174|Actinobacteria,3UWDH@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdJ	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_2_N,Ribonuc_red_lgC
REGS3_k127_2293475_1	469383.Cwoe_2565	3.887e-204	649.0	COG0243@1|root,COG0243@2|Bacteria,2GNYQ@201174|Actinobacteria,4CR1R@84995|Rubrobacteria	84995|Rubrobacteria	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
REGS3_k127_2341448_3	1313172.YM304_22550	4.31e-12	65.0	COG3173@1|root,COG3173@2|Bacteria,2HU7E@201174|Actinobacteria	201174|Actinobacteria	S	Aminoglycoside phosphotransferase	-	-	-	-	-	-	-	-	-	-	-	-	APH
REGS3_k127_2341448_2	1313172.YM304_22560	2.824e-34	135.0	COG3173@1|root,COG3173@2|Bacteria,2IQRM@201174|Actinobacteria	201174|Actinobacteria	S	Aminoglycoside phosphotransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_2341448_1	1313172.YM304_22570	1.953e-168	538.0	COG0820@1|root,COG0820@2|Bacteria,2GJ48@201174|Actinobacteria,4CMPY@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	-	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Radical_SAM
REGS3_k127_2341448_0	1313172.YM304_22580	2.048e-201	635.0	COG1164@1|root,COG1164@2|Bacteria,2IGPX@201174|Actinobacteria	201174|Actinobacteria	E	Oligopeptidase F	pepF	-	-	ko:K08602	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3,Peptidase_M3_N
REGS3_k127_2355370_6	67593.Physo126297	8.339e-06	49.0	COG0153@1|root,KOG0631@2759|Eukaryota,3QEJ2@4776|Peronosporales	4776|Peronosporales	G	Galactokinase galactose-binding signature	-	-	2.7.1.6	ko:K00849	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00554,M00632	R01092	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg
REGS3_k127_2355370_5	357808.RoseRS_4550	6.706e-23	103.0	COG3502@1|root,COG3502@2|Bacteria,2G9SI@200795|Chloroflexi,3760N@32061|Chloroflexia	32061|Chloroflexia	S	Protein of unknown function (DUF952)	-	-	-	-	-	-	-	-	-	-	-	-	DUF952
REGS3_k127_2355370_2	1313172.YM304_23350	3.404e-72	250.0	COG3428@1|root,COG3428@2|Bacteria,2HGDA@201174|Actinobacteria,4CNBH@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Bacterial PH domain	-	-	-	-	-	-	-	-	-	-	-	-	SHOCT,bPH_2
REGS3_k127_2355370_0	1313172.YM304_23340	4.443e-126	426.0	COG0210@1|root,COG0349@1|root,COG0210@2|Bacteria,COG0349@2|Bacteria,2GKRW@201174|Actinobacteria,4CNM0@84992|Acidimicrobiia	84992|Acidimicrobiia	L	UvrD-like helicase C-terminal domain	uvrD2	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HRDC,UvrD-helicase,UvrD_C
REGS3_k127_2355370_3	1229780.BN381_10319	2.419e-35	147.0	COG2050@1|root,COG2050@2|Bacteria,2I11Y@201174|Actinobacteria,3UXR4@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	Q	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
REGS3_k127_2355370_1	1313172.YM304_23330	5.648e-115	382.0	COG0708@1|root,COG0708@2|Bacteria,2GKEW@201174|Actinobacteria,4CN0I@84992|Acidimicrobiia	84992|Acidimicrobiia	L	Endonuclease/Exonuclease/phosphatase family	xthA	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
REGS3_k127_2355370_4	1313172.YM304_23320	2.648e-27	121.0	COG0539@1|root,COG0539@2|Bacteria,2I7V9@201174|Actinobacteria	201174|Actinobacteria	J	Zc3h12a-like Ribonuclease NYN domain	-	-	-	-	-	-	-	-	-	-	-	-	HC2,RNase_Zc3h12a
REGS3_k127_2400502_0	469383.Cwoe_2247	1.234e-129	428.0	COG0334@1|root,COG0334@2|Bacteria,2GKXG@201174|Actinobacteria,4CQ1D@84995|Rubrobacteria	84995|Rubrobacteria	E	Belongs to the Glu Leu Phe Val dehydrogenases family	-	-	1.4.1.9	ko:K00263	ko00280,ko00290,ko01100,ko01110,ko01130,map00280,map00290,map01100,map01110,map01130	-	R01088,R01434,R02196	RC00006,RC00036	ko00000,ko00001,ko01000	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
REGS3_k127_2400502_2	1146883.BLASA_0228	3.49e-106	351.0	COG1028@1|root,COG1028@2|Bacteria,2GK47@201174|Actinobacteria,4ETYM@85013|Frankiales	201174|Actinobacteria	IQ	KR domain	rhlG	-	1.1.1.69	ko:K00046	-	-	-	-	ko00000,ko01000	-	-	-	adh_short_C2
REGS3_k127_2400502_1	446471.Xcel_1262	8.412e-110	387.0	COG3973@1|root,COG3973@2|Bacteria,2GK30@201174|Actinobacteria,4F39B@85017|Promicromonosporaceae	201174|Actinobacteria	L	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_19,UvrD_C_2,Viral_helicase1
REGS3_k127_2581749_4	1906.SFRA_26800	8.138e-46	171.0	COG0446@1|root,COG0446@2|Bacteria,2GRTN@201174|Actinobacteria	201174|Actinobacteria	P	pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	DsrC,Pyr_redox_2
REGS3_k127_2581749_0	1313172.YM304_33470	0.0	1176.0	COG1014@1|root,COG4231@1|root,COG1014@2|Bacteria,COG4231@2|Bacteria,2GKBW@201174|Actinobacteria	201174|Actinobacteria	C	indolepyruvate ferredoxin oxidoreductase	-	-	1.2.7.8	ko:K00179,ko:K04090	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,POR,POR_N,TPP_enzyme_C
REGS3_k127_2581749_1	1313172.YM304_30920	4.554e-161	520.0	COG1960@1|root,COG1960@2|Bacteria	2|Bacteria	I	acyl-CoA dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
REGS3_k127_2581749_3	1313172.YM304_15640	8.949e-105	350.0	COG2141@1|root,COG2141@2|Bacteria,2HGTQ@201174|Actinobacteria,4CNXR@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
REGS3_k127_2581749_2	1313172.YM304_28200	3.785e-156	498.0	COG0624@1|root,COG0624@2|Bacteria,2GKKW@201174|Actinobacteria,4CP4J@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
REGS3_k127_2592105_0	1313172.YM304_24310	5.651e-106	346.0	COG0133@1|root,COG0133@2|Bacteria,2GM7Z@201174|Actinobacteria,4CMR9@84992|Acidimicrobiia	84992|Acidimicrobiia	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
REGS3_k127_2592105_2	1313172.YM304_24300	3.413e-90	302.0	COG0135@1|root,COG0135@2|Bacteria,2IHPP@201174|Actinobacteria,4CN2A@84992|Acidimicrobiia	84992|Acidimicrobiia	E	N-(5'phosphoribosyl)anthranilate (PRA) isomerase	trpF	-	5.3.1.24	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03509	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	PRAI
REGS3_k127_2592105_1	1313172.YM304_24270	1.017e-99	331.0	COG0134@1|root,COG0134@2|Bacteria,2GIVV@201174|Actinobacteria,4CN2P@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Indole-3-glycerol phosphate synthase	trpC	-	4.1.1.48	ko:K01609	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508	RC00944	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS
REGS3_k127_2592105_5	366602.Caul_3393	1.858e-06	54.0	COG1359@1|root,COG1359@2|Bacteria,1N65K@1224|Proteobacteria,2UE49@28211|Alphaproteobacteria,2KHAJ@204458|Caulobacterales	204458|Caulobacterales	S	PFAM Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
REGS3_k127_2592105_3	246194.CHY_1413	1.043e-59	222.0	COG0745@1|root,COG0745@2|Bacteria,1TPZ0@1239|Firmicutes,2484X@186801|Clostridia,42JAR@68295|Thermoanaerobacterales	186801|Clostridia	K	Transcriptional regulatory protein, C terminal	-	-	-	ko:K07775	ko02020,map02020	M00458	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
REGS3_k127_2592105_4	356851.JOAN01000004_gene1187	5.456e-20	101.0	COG0642@1|root,COG2205@2|Bacteria,2I53J@201174|Actinobacteria,4DMQB@85008|Micromonosporales	201174|Actinobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	2.7.13.3	ko:K07642	ko02020,map02020	M00450,M00645,M00646,M00648	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
REGS3_k127_2596753_4	196162.Noca_4465	2.338e-74	255.0	COG3261@1|root,COG3261@2|Bacteria,2GYM5@201174|Actinobacteria,4DSZ1@85009|Propionibacteriales	201174|Actinobacteria	C	Nickel-dependent hydrogenase	hycE	-	-	-	-	-	-	-	-	-	-	-	Complex1_30kDa,Complex1_49kDa,NiFeSe_Hases
REGS3_k127_2596753_13	196162.Noca_1026	7.114e-08	62.0	COG1432@1|root,COG1432@2|Bacteria,2GS87@201174|Actinobacteria	201174|Actinobacteria	S	Conserved Protein	-	-	-	-	-	-	-	-	-	-	-	-	NYN
REGS3_k127_2596753_6	298653.Franean1_2440	4.162e-72	254.0	COG1230@1|root,COG1230@2|Bacteria,2GMRZ@201174|Actinobacteria,4EVV0@85013|Frankiales	201174|Actinobacteria	P	Cation efflux family	czcD	-	-	ko:K16264	-	-	-	-	ko00000,ko02000	2.A.4.1	-	-	Cation_efflux
REGS3_k127_2596753_3	670487.Ocepr_2148	8.226e-98	336.0	COG0524@1|root,COG0524@2|Bacteria,1WJRH@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	PFAM pfkB family carbohydrate kinase	-	-	2.7.1.15	ko:K00852	ko00030,map00030	-	R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
REGS3_k127_2596753_7	298654.FraEuI1c_4326	2.91e-45	172.0	2EFGP@1|root,3399B@2|Bacteria,2IFZJ@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_2596753_2	1313172.YM304_34450	1.09e-121	403.0	COG1735@1|root,COG1735@2|Bacteria	2|Bacteria	S	zinc ion binding	-	-	-	-	-	-	-	-	-	-	-	-	DUF2817
REGS3_k127_2596753_8	1122609.AUGT01000009_gene3461	7.418e-38	147.0	COG3791@1|root,COG3791@2|Bacteria	2|Bacteria	S	Glutathione-dependent formaldehyde-activating	-	-	-	-	-	-	-	-	-	-	-	-	GFA
REGS3_k127_2596753_10	1193181.BN10_1720004	3.528e-34	141.0	COG5285@1|root,COG5285@2|Bacteria	2|Bacteria	Q	dioxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	PhyH
REGS3_k127_2596753_9	298655.KI912266_gene4709	1.744e-35	140.0	COG0346@1|root,COG0346@2|Bacteria,2GW7J@201174|Actinobacteria	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase,Glyoxalase_4
REGS3_k127_2596753_1	1205680.CAKO01000030_gene4841	3.603e-156	509.0	COG2159@1|root,COG2159@2|Bacteria,1N0C7@1224|Proteobacteria,2U1CT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
REGS3_k127_2596753_0	1282876.BAOK01000001_gene3028	1.284e-207	660.0	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,2TSZZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG3653 N-acyl-D-aspartate D-glutamate deacylase	MA20_22865	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
REGS3_k127_2596753_5	1123023.JIAI01000002_gene4957	4.677e-74	262.0	COG2141@1|root,COG2141@2|Bacteria,2GJRF@201174|Actinobacteria	201174|Actinobacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	1.5.98.2	ko:K00320	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R04464	RC01607	ko00000,ko00001,ko00002,ko01000	-	-	-	Bac_luciferase
REGS3_k127_2596753_12	1313172.YM304_21590	9.57e-10	69.0	COG4719@1|root,COG4719@2|Bacteria,2H8R9@201174|Actinobacteria	2|Bacteria	S	TIGRFAM conserved repeat domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF11
REGS3_k127_2596753_11	1123270.ATUR01000010_gene1903	5.503e-24	112.0	2EA9M@1|root,334E1@2|Bacteria,1ND0N@1224|Proteobacteria,2UIJ1@28211|Alphaproteobacteria,2K8CC@204457|Sphingomonadales	204457|Sphingomonadales	S	CHRD domain	-	-	-	-	-	-	-	-	-	-	-	-	CHRD
REGS3_k127_2601857_0	1048339.KB913029_gene859	5.516e-51	199.0	COG1766@1|root,COG1766@2|Bacteria,2HG9F@201174|Actinobacteria,4ES5A@85013|Frankiales	201174|Actinobacteria	N	The M ring may be actively involved in energy transduction	fliF	-	-	ko:K02409	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	YscJ_FliF,YscJ_FliF_C
REGS3_k127_2601857_3	1120971.AUCA01000011_gene2973	5.835e-09	61.0	COG1677@1|root,COG1677@2|Bacteria	2|Bacteria	N	Flagellar hook-basal body complex protein FliE	fliE	-	-	ko:K02408	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliE
REGS3_k127_2601857_1	543632.JOJL01000031_gene6119	7.517e-24	107.0	COG1558@1|root,COG1558@2|Bacteria,2IKRZ@201174|Actinobacteria,4DJ3N@85008|Micromonosporales	201174|Actinobacteria	N	Flagellar basal body rod protein	flgC	-	-	ko:K02388	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
REGS3_k127_2601857_4	525909.Afer_0134	3.136e-07	57.0	COG1815@1|root,COG1815@2|Bacteria,2IQWB@201174|Actinobacteria,4CNYW@84992|Acidimicrobiia	84992|Acidimicrobiia	N	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body	-	-	-	ko:K02387	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod
REGS3_k127_2601857_5	745014.OMB55_00023550	3.388e-06	55.0	COG1516@1|root,COG1516@2|Bacteria	2|Bacteria	N	flagellar protein fliS	fliS	-	-	ko:K02422	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliS
REGS3_k127_2601857_2	1120999.JONM01000019_gene3441	9.257e-16	90.0	COG1345@1|root,COG1345@2|Bacteria,1MUVP@1224|Proteobacteria,2VHMK@28216|Betaproteobacteria,2KRDS@206351|Neisseriales	206351|Neisseriales	N	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end	-	-	-	ko:K02407	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliD_C,FliD_N
REGS3_k127_2634587_1	1313172.YM304_23690	3.628e-247	771.0	COG0034@1|root,COG0034@2|Bacteria,2GK6I@201174|Actinobacteria,4CMWP@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_7,Pribosyltran
REGS3_k127_2634587_4	1313172.YM304_23700	4.643e-111	371.0	COG0152@1|root,COG0152@2|Bacteria,2GK3H@201174|Actinobacteria,4CN60@84992|Acidimicrobiia	84992|Acidimicrobiia	F	SAICAR synthetase	purC	-	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
REGS3_k127_2634587_5	1313172.YM304_23710	9.036e-73	256.0	COG0047@1|root,COG0047@2|Bacteria,2GMJY@201174|Actinobacteria,4CN8T@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purQ	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
REGS3_k127_2634587_0	1313172.YM304_23720	1.255e-315	990.0	COG0046@1|root,COG1828@1|root,COG0046@2|Bacteria,COG1828@2|Bacteria,2GKG6@201174|Actinobacteria,4CMZH@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
REGS3_k127_2634587_2	1463879.JOHP01000001_gene1481	2.402e-135	440.0	COG4948@1|root,COG4948@2|Bacteria,2GJJR@201174|Actinobacteria	201174|Actinobacteria	M	Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB)	menC	-	4.2.1.113	ko:K02549	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R04031	RC01053	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
REGS3_k127_2634587_3	1313172.YM304_13810	5.002e-130	421.0	COG2141@1|root,COG2141@2|Bacteria,2GJ3B@201174|Actinobacteria	201174|Actinobacteria	C	F420-dependent oxidoreductase, MSMEG_3544 family	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
REGS3_k127_2634587_6	92637.XP_007815812.1	1.84e-05	48.0	2D2M4@1|root,2SN9A@2759|Eukaryota,3A4G1@33154|Opisthokonta,3P4A1@4751|Fungi,3QUHR@4890|Ascomycota,21JK7@147550|Sordariomycetes,3TR25@5125|Hypocreales,3G5TY@34397|Clavicipitaceae	4751|Fungi	E	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
REGS3_k127_2642160_14	2055.JNXA01000005_gene361	2.86e-56	203.0	COG4638@1|root,COG4638@2|Bacteria,2GMB2@201174|Actinobacteria,4GH18@85026|Gordoniaceae	201174|Actinobacteria	P	Ring hydroxylating alpha subunit (catalytic domain)	-	-	-	-	-	-	-	-	-	-	-	-	Rieske,Ring_hydroxyl_A
REGS3_k127_2642160_3	1313172.YM304_30810	1.117e-106	361.0	COG1216@1|root,COG1216@2|Bacteria	2|Bacteria	V	Glycosyl transferase, family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
REGS3_k127_2642160_9	1313172.YM304_30800	2.924e-82	286.0	COG1376@1|root,COG3409@1|root,COG1376@2|Bacteria,COG3409@2|Bacteria	2|Bacteria	M	Peptidoglycan-binding domain 1 protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF2778,PG_binding_1,YkuD
REGS3_k127_2642160_2	1313172.YM304_30790	1.564e-126	413.0	COG0596@1|root,COG0596@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on ester bonds	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
REGS3_k127_2642160_10	1313172.YM304_30780	9.619e-79	281.0	COG2321@1|root,COG2321@2|Bacteria,2HBKZ@201174|Actinobacteria	201174|Actinobacteria	S	neutral zinc metallopeptidase	lpqM	-	-	ko:K07054	-	-	-	-	ko00000	-	-	-	Zn_peptidase
REGS3_k127_2642160_16	1206730.BAGA01000038_gene4547	8.108e-27	120.0	COG3544@1|root,COG3544@2|Bacteria,2GMGR@201174|Actinobacteria,4FU73@85025|Nocardiaceae	201174|Actinobacteria	S	Domain of unknown function (DUF305)	-	-	-	-	-	-	-	-	-	-	-	-	DUF305
REGS3_k127_2642160_20	28042.GU90_06820	8.795e-06	58.0	2E5E7@1|root,33065@2|Bacteria,2IN6X@201174|Actinobacteria,4E5FP@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_2642160_6	1415166.NONO_c36260	1.37e-98	329.0	COG1024@1|root,COG1024@2|Bacteria,2GKNU@201174|Actinobacteria	201174|Actinobacteria	I	Enoyl-CoA hydratase	-	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
REGS3_k127_2642160_17	1313172.YM304_08560	1.875e-26	119.0	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	luxT	-	-	-	-	-	-	-	-	-	-	-	TetR_N
REGS3_k127_2642160_11	1120950.KB892708_gene4333	6.244e-71	244.0	COG0494@1|root,COG0494@2|Bacteria,2GKUV@201174|Actinobacteria,4DRZ4@85009|Propionibacteriales	201174|Actinobacteria	L	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
REGS3_k127_2642160_13	1229780.BN381_360022	4.425e-58	216.0	COG1680@1|root,COG1680@2|Bacteria,2HEWU@201174|Actinobacteria,3UXIA@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
REGS3_k127_2642160_0	1313172.YM304_16690	9.797e-288	890.0	COG1884@1|root,COG1884@2|Bacteria,2GM65@201174|Actinobacteria,4CMUP@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
REGS3_k127_2642160_12	379066.GAU_2958	1.445e-68	243.0	COG0697@1|root,COG0697@2|Bacteria	2|Bacteria	EG	spore germination	-	-	-	-	-	-	-	-	-	-	-	-	EamA
REGS3_k127_2642160_5	710111.FraQA3DRAFT_1015	9.659e-100	354.0	COG0683@1|root,COG0683@2|Bacteria,2IAH6@201174|Actinobacteria	201174|Actinobacteria	E	Periplasmic binding protein	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
REGS3_k127_2642160_1	326424.FRAAL3089	2.48e-262	827.0	COG0559@1|root,COG4177@1|root,COG0559@2|Bacteria,COG4177@2|Bacteria,2GJHR@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997,ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
REGS3_k127_2642160_7	326424.FRAAL3090	5.173e-97	326.0	COG0411@1|root,COG0411@2|Bacteria,2I3FF@201174|Actinobacteria	201174|Actinobacteria	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,BCA_ABC_TP_C
REGS3_k127_2642160_8	710111.FraQA3DRAFT_1009	7.146e-97	327.0	COG0410@1|root,COG0410@2|Bacteria,2GKSQ@201174|Actinobacteria	201174|Actinobacteria	E	ABC transporter	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
REGS3_k127_2642160_15	1313172.YM304_30670	5.684e-40	160.0	COG0166@1|root,COG0363@1|root,COG0166@2|Bacteria,COG0363@2|Bacteria,2GJG0@201174|Actinobacteria,4CMVT@84992|Acidimicrobiia	84992|Acidimicrobiia	G	Phosphoglucose isomerase	pgi	-	5.3.1.9	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI
REGS3_k127_2642160_4	44060.JODL01000003_gene2858	4.687e-103	345.0	COG0166@1|root,COG0166@2|Bacteria,2GJG0@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the GPI family	pgi	-	5.3.1.9	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI
REGS3_k127_265341_0	1313172.YM304_38300	8.577e-124	406.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
REGS3_k127_265341_2	1028801.RG1141_CH13250	2.911e-73	257.0	COG0500@1|root,COG2226@2|Bacteria,1REVA@1224|Proteobacteria,2U929@28211|Alphaproteobacteria,4BC95@82115|Rhizobiaceae	28211|Alphaproteobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
REGS3_k127_265341_1	882083.SacmaDRAFT_4230	8.364e-106	355.0	COG3173@1|root,COG3173@2|Bacteria,2GKUU@201174|Actinobacteria,4E1NH@85010|Pseudonocardiales	201174|Actinobacteria	S	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
REGS3_k127_265341_3	2074.JNYD01000014_gene7077	1.733e-57	209.0	COG0783@1|root,COG0783@2|Bacteria,2IFDP@201174|Actinobacteria	201174|Actinobacteria	P	Belongs to the Dps family	dps	-	-	ko:K04047	-	-	-	-	ko00000,ko03036	-	-	-	Ferritin
REGS3_k127_265341_4	529884.Rhola_00012670	2.628e-47	177.0	COG1914@1|root,COG1914@2|Bacteria,2GJSM@201174|Actinobacteria,4FNCM@85023|Microbacteriaceae	201174|Actinobacteria	P	Natural resistance-associated macrophage protein	-	-	-	-	-	-	-	-	-	-	-	-	Nramp
REGS3_k127_2672855_7	1385518.N798_01345	6.234e-13	72.0	2F7D1@1|root,33ZU2@2|Bacteria,2ITDT@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_2672855_5	1035308.AQYY01000001_gene3239	1.563e-26	115.0	COG0607@1|root,COG0607@2|Bacteria	2|Bacteria	P	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	-	-	-	ko:K03972	-	-	-	-	ko00000	-	-	-	Rhodanese
REGS3_k127_2672855_3	1166018.FAES_0401	3.704e-49	190.0	COG3509@1|root,COG3509@2|Bacteria,4NHFS@976|Bacteroidetes,47RR1@768503|Cytophagia	976|Bacteroidetes	Q	Esterase PHB depolymerase	-	-	-	ko:K03932	-	-	-	-	ko00000	-	CE1	-	Abhydrolase_2,Esterase_phd
REGS3_k127_2672855_0	1240349.ANGC01000004_gene1855	1.26e-189	602.0	COG0477@1|root,COG2814@2|Bacteria,2GNBV@201174|Actinobacteria,4FWA7@85025|Nocardiaceae	201174|Actinobacteria	EGP	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
REGS3_k127_2672855_1	1386089.N865_14270	1.252e-119	397.0	arCOG10456@1|root,2ZA6T@2|Bacteria,2IT80@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_2672855_2	1108045.GORHZ_134_00040	1.682e-72	257.0	2DM5A@1|root,31SBV@2|Bacteria,2IPT3@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_2672855_4	882083.SacmaDRAFT_4484	2.724e-30	126.0	COG3832@1|root,COG3832@2|Bacteria	2|Bacteria	J	glyoxalase III activity	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_N
REGS3_k127_2682575_18	1385520.N802_09265	1.327e-21	103.0	2FJ66@1|root,34AWA@2|Bacteria,2H9MS@201174|Actinobacteria,4FJGM@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_2682575_17	215803.DB30_7934	1.259e-22	102.0	COG1977@1|root,COG1977@2|Bacteria,1N4M4@1224|Proteobacteria,43BB7@68525|delta/epsilon subdivisions,2X6QD@28221|Deltaproteobacteria,2Z3C9@29|Myxococcales	28221|Deltaproteobacteria	H	ThiS family	-	-	-	-	-	-	-	-	-	-	-	-	ThiS
REGS3_k127_2682575_3	1121127.JAFA01000007_gene5236	1.572e-137	447.0	COG4447@1|root,COG4447@2|Bacteria,1ND1J@1224|Proteobacteria,2VMA5@28216|Betaproteobacteria,1K2TY@119060|Burkholderiaceae	28216|Betaproteobacteria	S	protein related to plant photosystem II stability assembly factor	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_2682575_0	1313172.YM304_14140	1.058e-263	820.0	COG1960@1|root,COG1960@2|Bacteria,2GIX8@201174|Actinobacteria,4CMR3@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.12	ko:K14448	ko00630,ko01120,ko01200,map00630,map01120,map01200	M00373	R09293	RC02483	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
REGS3_k127_2682575_10	640081.Dsui_0979	3.585e-61	218.0	COG1611@1|root,COG1611@2|Bacteria,1RD59@1224|Proteobacteria,2VRA6@28216|Betaproteobacteria,2KWBF@206389|Rhodocyclales	206389|Rhodocyclales	S	Possible lysine decarboxylase	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
REGS3_k127_2682575_14	1463936.JOJI01000005_gene4004	2.022e-34	142.0	COG1708@1|root,COG1708@2|Bacteria,2II5V@201174|Actinobacteria	201174|Actinobacteria	S	nucleotidyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF4111,NTP_transf_2
REGS3_k127_2682575_7	1280952.HJA_16998	1.175e-97	332.0	COG1680@1|root,COG1680@2|Bacteria,1MY4Y@1224|Proteobacteria,2U8KF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	COG1680 Beta-lactamase class C and other penicillin binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
REGS3_k127_2682575_5	1313172.YM304_14240	1.306e-130	429.0	COG0392@1|root,COG0392@2|Bacteria,2HG5A@201174|Actinobacteria,4CN1V@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	ko:K07027,ko:K20468	-	-	-	-	ko00000,ko02000	4.D.2,4.D.2.4.1	-	-	LPG_synthase_TM
REGS3_k127_2682575_8	1313172.YM304_14250	1.274e-97	323.0	COG2030@1|root,COG2030@2|Bacteria,2GN4R@201174|Actinobacteria,4CMYB@84992|Acidimicrobiia	84992|Acidimicrobiia	I	MaoC like domain	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
REGS3_k127_2682575_11	1122138.AQUZ01000036_gene5479	2.787e-52	198.0	COG0500@1|root,COG2226@2|Bacteria,2HWAV@201174|Actinobacteria,4DQJ7@85009|Propionibacteriales	201174|Actinobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
REGS3_k127_2682575_9	1313172.YM304_14260	3.63e-96	323.0	COG1194@1|root,COG1194@2|Bacteria,2GJD9@201174|Actinobacteria,4CNWS@84992|Acidimicrobiia	84992|Acidimicrobiia	L	endonuclease III	-	-	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
REGS3_k127_2682575_16	1313172.YM304_14660	2.028e-23	101.0	2DS3D@1|root,33EC4@2|Bacteria,2GXNR@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_2682575_13	1313172.YM304_14670	6.72e-36	138.0	2E6FA@1|root,3312Q@2|Bacteria,2GUWJ@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_2682575_1	1313172.YM304_14680	1.752e-200	635.0	COG0526@1|root,COG0526@2|Bacteria,2IET9@201174|Actinobacteria	201174|Actinobacteria	CO	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_2682575_6	1313172.YM304_14700	1.463e-114	376.0	COG1235@1|root,COG1235@2|Bacteria,2IJCH@201174|Actinobacteria	201174|Actinobacteria	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
REGS3_k127_2682575_15	1313172.YM304_14710	5.516e-29	126.0	COG2259@1|root,COG2259@2|Bacteria,2ICCJ@201174|Actinobacteria	201174|Actinobacteria	O	Methylamine utilisation protein MauE	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,MauE
REGS3_k127_2682575_2	1306174.JODP01000007_gene2522	9.479e-193	623.0	COG1770@1|root,COG1770@2|Bacteria,2GNA9@201174|Actinobacteria	201174|Actinobacteria	E	Peptidase, S9A B C family, catalytic domain protein	ptrB	-	3.4.21.83	ko:K01354	ko05142,ko05143,map05142,map05143	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
REGS3_k127_2682575_12	1313172.YM304_14730	2.511e-39	148.0	COG1141@1|root,COG1141@2|Bacteria	2|Bacteria	C	electron transfer activity	fer	GO:0003674,GO:0003824,GO:0005488,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016491,GO:0022900,GO:0044237,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114	-	ko:K05337	-	-	-	-	ko00000	-	-	-	Fer4_13
REGS3_k127_2682575_4	2055.JNXA01000005_gene361	8.145e-136	439.0	COG4638@1|root,COG4638@2|Bacteria,2GMB2@201174|Actinobacteria,4GH18@85026|Gordoniaceae	201174|Actinobacteria	P	Ring hydroxylating alpha subunit (catalytic domain)	-	-	-	-	-	-	-	-	-	-	-	-	Rieske,Ring_hydroxyl_A
REGS3_k127_2684645_10	1122622.ATWJ01000009_gene3319	5.959e-48	175.0	COG2154@1|root,COG2154@2|Bacteria,2IHZE@201174|Actinobacteria,4FGSP@85021|Intrasporangiaceae	201174|Actinobacteria	H	Pterin 4 alpha carbinolamine dehydratase	-	-	4.2.1.96	ko:K01724	ko00790,map00790	-	R04734	RC01208	ko00000,ko00001,ko01000,ko04147	-	-	-	Pterin_4a
REGS3_k127_2684645_7	305900.GV64_19225	4.355e-62	226.0	COG1960@1|root,COG1960@2|Bacteria,1P4V3@1224|Proteobacteria,1RZBS@1236|Gammaproteobacteria,1XPUB@135619|Oceanospirillales	135619|Oceanospirillales	I	Acyl-CoA dehydrogenase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_N
REGS3_k127_2684645_4	1301098.PKB_4260	1.022e-166	533.0	COG1960@1|root,COG1960@2|Bacteria,1MVJC@1224|Proteobacteria,1RPW2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	COG1960 Acyl-CoA dehydrogenases	-	-	1.3.8.4	ko:K00253	ko00280,ko01100,map00280,map01100	M00036	R04095	RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
REGS3_k127_2684645_12	2055.JNXA01000012_gene2842	1.608e-20	101.0	2F5RB@1|root,33YA7@2|Bacteria,2GMGC@201174|Actinobacteria,4GC6M@85026|Gordoniaceae	201174|Actinobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2,SnoaL_4
REGS3_k127_2684645_5	35754.JNYJ01000043_gene4422	9.513e-124	406.0	COG3491@1|root,COG3491@2|Bacteria,2GT52@201174|Actinobacteria,4DENK@85008|Micromonosporales	201174|Actinobacteria	C	Belongs to the iron ascorbate-dependent oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	2OG-FeII_Oxy,DIOX_N
REGS3_k127_2684645_9	262316.MAP_1321c	1.494e-52	189.0	COG1545@1|root,COG1545@2|Bacteria,2IFQP@201174|Actinobacteria,238SF@1762|Mycobacteriaceae	201174|Actinobacteria	S	nucleic-acid-binding protein containing a Zn-ribbon	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
REGS3_k127_2684645_2	36809.MAB_2619	1.734e-210	659.0	COG0183@1|root,COG0183@2|Bacteria,2GIY0@201174|Actinobacteria,2333E@1762|Mycobacteriaceae	201174|Actinobacteria	I	lipid-transfer protein	-	-	-	-	-	-	-	-	-	-	-	-	Thiolase_N,ketoacyl-synt
REGS3_k127_2684645_11	211114.JOEF01000017_gene3831	3.324e-24	112.0	COG3832@1|root,COG3832@2|Bacteria,2IH7G@201174|Actinobacteria,4E5GQ@85010|Pseudonocardiales	201174|Actinobacteria	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
REGS3_k127_2684645_3	298654.FraEuI1c_1252	2.811e-189	597.0	COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria	201174|Actinobacteria	I	Belongs to the thiolase family	-	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
REGS3_k127_2684645_8	1313172.YM304_22990	2.353e-54	196.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	pac	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_7
REGS3_k127_2684645_1	1370120.AUWR01000020_gene2859	3.907e-225	717.0	COG3653@1|root,COG3653@2|Bacteria,2GKMK@201174|Actinobacteria,2353H@1762|Mycobacteriaceae	201174|Actinobacteria	Q	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
REGS3_k127_2684645_0	1229780.BN381_290032	2.657e-275	867.0	COG3119@1|root,COG3119@2|Bacteria,2GJ8H@201174|Actinobacteria	201174|Actinobacteria	P	Pfam Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
REGS3_k127_2684645_6	1313172.YM304_28930	2.911e-66	234.0	COG0778@1|root,COG0778@2|Bacteria	2|Bacteria	C	coenzyme F420-1:gamma-L-glutamate ligase activity	ydjA	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
REGS3_k127_2684645_13	1463864.JOGO01000012_gene5665	6.234e-13	72.0	COG3393@1|root,COG3393@2|Bacteria,2GMQC@201174|Actinobacteria	201174|Actinobacteria	S	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	FR47
REGS3_k127_2785599_2	1313172.YM304_25520	4.86e-159	506.0	COG0761@1|root,COG0761@2|Bacteria,2GIZ7@201174|Actinobacteria,4CMP7@84992|Acidimicrobiia	84992|Acidimicrobiia	IM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	-	LYTB
REGS3_k127_2785599_1	1313172.YM304_25530	5.295e-207	652.0	COG1625@1|root,COG1625@2|Bacteria,2H3RR@201174|Actinobacteria,4CMW9@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Protein of unknown function (DUF512)	-	-	-	-	-	-	-	-	-	-	-	-	DUF512
REGS3_k127_2785599_0	1313172.YM304_25540	9.627e-208	654.0	COG1160@1|root,COG1160@2|Bacteria,2GJ8J@201174|Actinobacteria,4CMR6@84992|Acidimicrobiia	84992|Acidimicrobiia	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
REGS3_k127_2785599_6	1380346.JNIH01000031_gene1019	1.195e-06	57.0	COG1609@1|root,COG1609@2|Bacteria,2GSWK@201174|Actinobacteria	201174|Actinobacteria	K	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	LacI,Phage_int_SAM_3,Phage_integrase
REGS3_k127_2785599_4	1229203.KI301992_gene2269	2.75e-35	141.0	COG0454@1|root,COG0456@2|Bacteria,2HG6T@201174|Actinobacteria,3UXNW@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
REGS3_k127_2785599_3	1313172.YM304_16590	4.129e-47	175.0	COG3291@1|root,COG3391@1|root,COG3291@2|Bacteria,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_278762_5	1173263.Syn7502_00910	1.104e-18	94.0	COG1357@1|root,COG1357@2|Bacteria,1GIV5@1117|Cyanobacteria,1H37A@1129|Synechococcus	1117|Cyanobacteria	S	Pentapeptide repeats (9 copies)	-	-	-	-	-	-	-	-	-	-	-	-	Pentapeptide
REGS3_k127_278762_4	313606.M23134_01445	1.069e-32	140.0	COG3291@1|root,COG5184@1|root,COG3291@2|Bacteria,COG5184@2|Bacteria,4NPFW@976|Bacteroidetes,47X9T@768503|Cytophagia	976|Bacteroidetes	DZ	ig-like, plexins, transcription factors	-	-	-	-	-	-	-	-	-	-	-	-	DUF5013,TIG
REGS3_k127_278762_6	1229203.KI301992_gene1825	0.0002134	53.0	2EM6P@1|root,33EVW@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_278762_1	1313172.YM304_18980	8.13e-63	223.0	COG0406@1|root,COG0406@2|Bacteria	2|Bacteria	G	alpha-ribazole phosphatase activity	rnhA	GO:0003674,GO:0003676,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005488,GO:0006139,GO:0006401,GO:0006725,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016070,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016891,GO:0016893,GO:0017144,GO:0018130,GO:0019438,GO:0019439,GO:0032296,GO:0033013,GO:0033014,GO:0034641,GO:0034655,GO:0042364,GO:0042578,GO:0043170,GO:0043755,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0046700,GO:0051186,GO:0051188,GO:0071667,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576	3.1.26.4,3.1.3.3,3.1.3.73,3.1.3.85,5.4.2.12	ko:K02226,ko:K15634,ko:K22305,ko:K22306,ko:K22316	ko00010,ko00260,ko00680,ko00860,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03030,map00010,map00260,map00680,map00860,map01100,map01110,map01120,map01130,map01200,map01230,map03030	M00001,M00002,M00003,M00122	R00582,R01518,R04594,R11173	RC00017,RC00536	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	His_Phos_1,RVT_3
REGS3_k127_278762_2	1313172.YM304_18970	7.669e-42	166.0	2C2HI@1|root,345RC@2|Bacteria,2H8AE@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_278762_3	1313172.YM304_18960	3.596e-38	151.0	COG1579@1|root,COG1579@2|Bacteria	2|Bacteria	-	-	CP_0228	-	3.5.4.16	ko:K07164,ko:K22391	ko00790,ko01100,map00790,map01100	M00126	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	zf-RING_7
REGS3_k127_278762_0	1313172.YM304_18950	2.141e-237	753.0	COG0744@1|root,COG0744@2|Bacteria,2GK21@201174|Actinobacteria	201174|Actinobacteria	M	penicillin-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Transgly,Transpeptidase
REGS3_k127_2787979_34	996637.SGM_0442	3.245e-35	145.0	COG0645@1|root,COG0645@2|Bacteria,2IKMM@201174|Actinobacteria	201174|Actinobacteria	S	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_33
REGS3_k127_2787979_10	485913.Krac_0187	4.454e-163	521.0	COG2334@1|root,COG2334@2|Bacteria	2|Bacteria	S	homoserine kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	APH,EcKinase
REGS3_k127_2787979_44	1048339.KB913029_gene3361	7.627e-09	66.0	2ASI2@1|root,31HYH@2|Bacteria,2HA75@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_2787979_9	1313172.YM304_38460	1.639e-163	524.0	COG0489@1|root,COG2151@1|root,COG0489@2|Bacteria,COG2151@2|Bacteria,2H1YI@201174|Actinobacteria,4CNPI@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	-	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	FeS_assembly_P,ParA
REGS3_k127_2787979_25	1313172.YM304_38440	4.701e-47	171.0	COG0316@1|root,COG0316@2|Bacteria,2IHR0@201174|Actinobacteria,4CN53@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Iron-sulphur cluster biosynthesis	erpA	-	-	ko:K13628	-	-	-	-	ko00000,ko03016	-	-	-	Fe-S_biosyn
REGS3_k127_2787979_23	1313172.YM304_38430	1.135e-56	216.0	COG0526@1|root,COG0526@2|Bacteria,2HDQJ@201174|Actinobacteria	201174|Actinobacteria	CO	COG0526, thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_2787979_26	1313172.YM304_38420	2.267e-43	179.0	COG2335@1|root,COG2885@1|root,COG2335@2|Bacteria,COG2885@2|Bacteria	2|Bacteria	M	chlorophyll binding	mpt70	GO:0005575,GO:0005576,GO:0005615,GO:0005623,GO:0005886,GO:0008150,GO:0009605,GO:0009607,GO:0016020,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043207,GO:0044403,GO:0044419,GO:0044421,GO:0044464,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0071944,GO:0075136	-	ko:K02067,ko:K03286,ko:K03640	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	1.B.6,2.C.1.2,3.A.1.27	-	-	CHRD,COP23,Fasciclin,OmpA
REGS3_k127_2787979_41	1250232.JQNJ01000001_gene1090	1.16e-12	78.0	COG3743@1|root,COG3743@2|Bacteria,4NQAU@976|Bacteroidetes,1I38D@117743|Flavobacteriia	976|Bacteroidetes	S	rRNA binding	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_2787979_32	1313172.YM304_38390	2.702e-37	144.0	COG0251@1|root,COG0251@2|Bacteria	2|Bacteria	J	oxidation-reduction process	-	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
REGS3_k127_2787979_20	640081.Dsui_2185	1.249e-64	227.0	COG2818@1|root,COG2818@2|Bacteria,1R9X5@1224|Proteobacteria,2VQC5@28216|Betaproteobacteria,2KWA8@206389|Rhodocyclales	206389|Rhodocyclales	L	Methyladenine glycosylase	tag	-	3.2.2.20	ko:K01246	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Adenine_glyco
REGS3_k127_2787979_7	565045.NOR51B_726	5.031e-166	536.0	COG0076@1|root,COG0076@2|Bacteria,1MWUX@1224|Proteobacteria,1RQ8G@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	decarboxylase	-	-	4.1.1.105,4.1.1.28	ko:K01593	ko00350,ko00360,ko00380,ko00901,ko00950,ko00965,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00350,map00360,map00380,map00901,map00950,map00965,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00037,M00042	R00685,R00699,R00736,R02080,R02701,R04909	RC00299	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyridoxal_deC
REGS3_k127_2787979_2	1313172.YM304_38370	4.37e-236	740.0	COG0402@1|root,COG0402@2|Bacteria,2GZ2Q@201174|Actinobacteria,4CNCB@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
REGS3_k127_2787979_33	1313172.YM304_38360	8.729e-36	145.0	COG2755@1|root,COG2755@2|Bacteria	2|Bacteria	E	lipolytic protein G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,Calx-beta,FG-GAP,Flg_new,Laminin_G_3,Lipase_GDSL_2,M60-like_N,PA14,Peptidase_M60
REGS3_k127_2787979_29	1382356.JQMP01000003_gene2013	1.486e-40	161.0	COG2141@1|root,COG2141@2|Bacteria,2G8NG@200795|Chloroflexi,27Y54@189775|Thermomicrobia	189775|Thermomicrobia	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
REGS3_k127_2787979_17	469371.Tbis_1167	2.771e-88	302.0	COG0451@1|root,COG0451@2|Bacteria,2GNH5@201174|Actinobacteria,4E1RV@85010|Pseudonocardiales	201174|Actinobacteria	GM	NAD dependent epimerase/dehydratase family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
REGS3_k127_2787979_37	675635.Psed_1298	1.736e-24	108.0	COG0695@1|root,COG0695@2|Bacteria,2HNF0@201174|Actinobacteria,4E6IC@85010|Pseudonocardiales	201174|Actinobacteria	O	PFAM glutaredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Glutaredoxin
REGS3_k127_2787979_14	1313172.YM304_38350	2.208e-95	318.0	COG0745@1|root,COG0745@2|Bacteria,2GJGU@201174|Actinobacteria,4CN27@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Trans_reg_C
REGS3_k127_2787979_3	1313172.YM304_38340	1.283e-226	708.0	COG0174@1|root,COG0174@2|Bacteria,2GJ2I@201174|Actinobacteria,4CMV7@84992|Acidimicrobiia	84992|Acidimicrobiia	E	glutamine synthetase	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
REGS3_k127_2787979_11	981369.JQMJ01000004_gene1222	1.536e-150	484.0	COG0174@1|root,COG0174@2|Bacteria,2GKU9@201174|Actinobacteria,2NG3X@228398|Streptacidiphilus	201174|Actinobacteria	E	Glutamine synthetase, beta-Grasp domain	glnII	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
REGS3_k127_2787979_30	1313172.YM304_27380	6.635e-40	160.0	2DPD0@1|root,331J4@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_2787979_5	1313172.YM304_38320	4.373e-179	589.0	COG2133@1|root,COG2133@2|Bacteria	2|Bacteria	G	pyrroloquinoline quinone binding	-	-	-	-	-	-	-	-	-	-	-	-	CBM_6,GSDH,Ig_2,Ig_3,PA14,PKD
REGS3_k127_2787979_0	1313172.YM304_38270	5.801e-281	872.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,2GK2C@201174|Actinobacteria,4CMPV@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	nadE	-	6.3.5.1	ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
REGS3_k127_2787979_38	1265505.ATUG01000002_gene2349	1.765e-21	107.0	COG0477@1|root,COG2814@2|Bacteria,1R842@1224|Proteobacteria,42QBY@68525|delta/epsilon subdivisions,2WKB6@28221|Deltaproteobacteria,2MHNH@213118|Desulfobacterales	28221|Deltaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
REGS3_k127_2787979_4	1313172.YM304_03200	1.176e-202	637.0	COG0527@1|root,COG0527@2|Bacteria,2GN0G@201174|Actinobacteria,4CMX1@84992|Acidimicrobiia	84992|Acidimicrobiia	E	ACT domain	ask	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7
REGS3_k127_2787979_8	1283283.ATXA01000010_gene4577	1.27e-165	526.0	COG0136@1|root,COG0136@2|Bacteria,2GJJ8@201174|Actinobacteria,4ERE4@85013|Frankiales	201174|Actinobacteria	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	GO:0003674,GO:0003824,GO:0004073,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0019877,GO:0030312,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv3708c	Semialdhyde_dh,Semialdhyde_dhC
REGS3_k127_2787979_27	1313172.YM304_41140	1.242e-42	157.0	COG1694@1|root,COG1694@2|Bacteria,2ISAF@201174|Actinobacteria	201174|Actinobacteria	S	Phosphoribosyl-ATP pyrophosphohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	MazG
REGS3_k127_2787979_46	436229.JOEH01000009_gene4564	1.7e-06	50.0	COG1609@1|root,COG1609@2|Bacteria,2GSWK@201174|Actinobacteria,2NJKA@228398|Streptacidiphilus	201174|Actinobacteria	K	Phage integrase, N-terminal SAM-like domain	-	-	-	-	-	-	-	-	-	-	-	-	LacI,Phage_int_SAM_3,Phage_integrase
REGS3_k127_2787979_28	1313172.YM304_41120	1.134e-41	158.0	COG0745@1|root,COG0745@2|Bacteria	1313172.YM304_41120|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_2787979_13	1313172.YM304_38170	8.216e-121	402.0	COG0003@1|root,COG0003@2|Bacteria,2GJYN@201174|Actinobacteria,4CN0P@84992|Acidimicrobiia	84992|Acidimicrobiia	P	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	ArsA_ATPase
REGS3_k127_2787979_18	1313172.YM304_38180	8.466e-84	292.0	COG0003@1|root,COG0003@2|Bacteria,2GJ0J@201174|Actinobacteria,4CN5H@84992|Acidimicrobiia	84992|Acidimicrobiia	P	Anion-transporting ATPase	-	-	-	-	-	-	-	-	-	-	-	-	ArsA_ATPase
REGS3_k127_2787979_12	1313172.YM304_38190	2.632e-139	458.0	COG1030@1|root,COG1030@2|Bacteria,2IATM@201174|Actinobacteria	201174|Actinobacteria	O	NfeD-like C-terminal, partner-binding	-	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	NfeD
REGS3_k127_2787979_24	648757.Rvan_2641	1.084e-55	205.0	COG0500@1|root,COG2226@2|Bacteria,1R1CY@1224|Proteobacteria,2TZ0H@28211|Alphaproteobacteria,3N81J@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	Q	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_2787979_39	1229780.BN381_100117	1.008e-18	91.0	2CC1Y@1|root,32S23@2|Bacteria,2IQS5@201174|Actinobacteria,3UWYX@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	K	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA	whiB3	-	-	ko:K18955	-	-	-	-	ko00000,ko03000	-	-	-	Whib
REGS3_k127_2787979_19	1089544.KB912942_gene1783	7.473e-77	268.0	COG1073@1|root,COG1073@2|Bacteria,2IFI1@201174|Actinobacteria	201174|Actinobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
REGS3_k127_2787979_1	1313172.YM304_38210	1.721e-249	781.0	COG3276@1|root,COG3276@2|Bacteria,2I7V8@201174|Actinobacteria	201174|Actinobacteria	J	Elongation factor SelB, winged helix	-	-	-	ko:K03833	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,SelB-wing_3
REGS3_k127_2787979_6	1313172.YM304_38220	8.672e-167	534.0	COG1921@1|root,COG1921@2|Bacteria,2HFGK@201174|Actinobacteria	201174|Actinobacteria	E	Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis	selA	-	2.9.1.1	ko:K01042	ko00450,ko00970,map00450,map00970	-	R08219	RC01246	ko00000,ko00001,ko01000	-	-	-	Se-cys_synth_N,SelA
REGS3_k127_2787979_22	1313172.YM304_38230	2.958e-57	207.0	COG0756@1|root,COG0756@2|Bacteria,2IHYY@201174|Actinobacteria,4CN99@84992|Acidimicrobiia	84992|Acidimicrobiia	F	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA	dut	-	3.6.1.23	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00053	R02100,R11896	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	dUTPase
REGS3_k127_2787979_48	3885.XP_007162899.1	0.0001347	51.0	COG0454@1|root,KOG3396@2759|Eukaryota,37U5I@33090|Viridiplantae,3GI5M@35493|Streptophyta,4JP31@91835|fabids	35493|Streptophyta	M	Glucosamine 6-phosphate	-	GO:0003674,GO:0003824,GO:0004343,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0006040,GO:0006044,GO:0006047,GO:0006048,GO:0006139,GO:0006725,GO:0006793,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0009058,GO:0009225,GO:0009226,GO:0009987,GO:0012505,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0018130,GO:0019438,GO:0034641,GO:0034654,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046349,GO:0046483,GO:0055086,GO:0071704,GO:1901071,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901576	2.3.1.4	ko:K00621	ko00520,map00520	-	R02058	RC00004,RC00166	ko00000,ko00001,ko01000	-	-	-	Acetyltransf_1
REGS3_k127_2787979_31	1187851.A33M_0934	6.522e-39	164.0	2DM58@1|root,31S4C@2|Bacteria,1RGAH@1224|Proteobacteria,2U7JN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_2787979_21	1206720.BAFQ01000070_gene1888	3.935e-61	217.0	COG0500@1|root,COG2226@2|Bacteria,2H9G5@201174|Actinobacteria,4FUPK@85025|Nocardiaceae	201174|Actinobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23
REGS3_k127_2787979_15	1313172.YM304_01450	9.476e-95	321.0	COG0111@1|root,COG0111@2|Bacteria,2GP09@201174|Actinobacteria,4CN78@84992|Acidimicrobiia	84992|Acidimicrobiia	EH	D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh,2-Hacid_dh_C
REGS3_k127_2787979_36	1313172.YM304_03620	1.071e-30	129.0	2FKUI@1|root,34CEY@2|Bacteria,2HCF2@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_2787979_16	1313172.YM304_03610	4.384e-89	310.0	COG4962@1|root,COG4962@2|Bacteria,2GKKJ@201174|Actinobacteria,4CNAY@84992|Acidimicrobiia	84992|Acidimicrobiia	U	type II secretion system protein E	-	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
REGS3_k127_2787979_43	1313172.YM304_03600	6.088e-11	72.0	COG4965@1|root,COG4965@2|Bacteria	2|Bacteria	U	Type ii secretion system	-	-	-	ko:K12510	-	-	-	-	ko00000,ko02044	-	-	-	-
REGS3_k127_2787979_35	1313172.YM304_03590	1.803e-31	132.0	COG2064@1|root,COG2064@2|Bacteria	2|Bacteria	NU	Type II secretion system (T2SS), protein F	tadC	-	-	ko:K12511	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
REGS3_k127_2787979_42	1313172.YM304_03570	2.132e-12	74.0	COG4961@1|root,COG4961@2|Bacteria	2|Bacteria	U	PFAM TadE family protein	-	-	-	-	-	-	-	-	-	-	-	-	TadE
REGS3_k127_2787979_45	446470.Snas_0501	3.029e-08	60.0	COG1366@1|root,COG1366@2|Bacteria,2HPDJ@201174|Actinobacteria,4EYWR@85014|Glycomycetales	201174|Actinobacteria	T	STAS domain	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS_2
REGS3_k127_2811748_5	745014.OMB55_00019830	1.34e-72	255.0	COG3217@1|root,COG3217@2|Bacteria,1Q80Q@1224|Proteobacteria,1SFUE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Fe-S protein	-	-	-	ko:K07140	-	-	-	-	ko00000	-	-	-	MOSC,MOSC_N
REGS3_k127_2811748_2	1313172.YM304_26310	3.177e-131	427.0	COG1611@1|root,COG1611@2|Bacteria,2GKJH@201174|Actinobacteria,4CMXM@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Possible lysine decarboxylase	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
REGS3_k127_2811748_1	1313172.YM304_26290	2.713e-152	489.0	COG0176@1|root,COG0176@2|Bacteria,2GMF9@201174|Actinobacteria,4CN0N@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
REGS3_k127_2811748_0	1313172.YM304_26280	3.379e-274	862.0	COG0021@1|root,COG0021@2|Bacteria,2GJ1K@201174|Actinobacteria,4CNKC@84992|Acidimicrobiia	84992|Acidimicrobiia	G	Transketolase, pyrimidine binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
REGS3_k127_2811748_6	345341.KUTG_05365	2.223e-63	232.0	COG1820@1|root,COG1820@2|Bacteria,2GK1E@201174|Actinobacteria,4DX8Z@85010|Pseudonocardiales	201174|Actinobacteria	G	Belongs to the metallo-dependent hydrolases superfamily. NagA family	nagA	-	3.5.1.25	ko:K01443	ko00520,ko01130,map00520,map01130	-	R02059	RC00166,RC00300	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
REGS3_k127_2811748_4	1313172.YM304_26220	2.267e-78	271.0	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	-	-	-	ko:K09017	-	-	-	-	ko00000,ko03000	-	-	-	TetR_N
REGS3_k127_2811748_3	1313172.YM304_29790	7.764e-86	306.0	COG1835@1|root,COG2845@1|root,COG1835@2|Bacteria,COG2845@2|Bacteria,2GKI5@201174|Actinobacteria,4CNC6@84992|Acidimicrobiia	201174|Actinobacteria	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
REGS3_k127_28139_10	164757.Mjls_1585	3.209e-10	68.0	COG0697@1|root,COG0697@2|Bacteria,2GM50@201174|Actinobacteria,233AP@1762|Mycobacteriaceae	201174|Actinobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
REGS3_k127_28139_4	1007105.PT7_0370	3.959e-78	271.0	COG0329@1|root,COG0329@2|Bacteria,1MXI1@1224|Proteobacteria,2VRPR@28216|Betaproteobacteria,3T91J@506|Alcaligenaceae	28216|Betaproteobacteria	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
REGS3_k127_28139_1	1040983.AXAE01000018_gene5911	1.385e-107	358.0	COG3938@1|root,COG3938@2|Bacteria,1N02K@1224|Proteobacteria,2U1Z3@28211|Alphaproteobacteria,43J76@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Proline racemase	-	-	-	-	-	-	-	-	-	-	-	-	Pro_racemase
REGS3_k127_28139_5	653045.Strvi_3736	4.663e-68	247.0	COG0665@1|root,COG0665@2|Bacteria,2GMR7@201174|Actinobacteria	201174|Actinobacteria	E	D-amino acid	-	-	1.4.5.1	ko:K00285	ko00360,map00360	-	R01374,R09493	RC00006,RC00025	ko00000,ko00001,ko01000	-	-	-	DAO
REGS3_k127_28139_8	1003195.SCAT_2696	4.961e-48	184.0	COG2423@1|root,COG2423@2|Bacteria,2GJ0U@201174|Actinobacteria	201174|Actinobacteria	E	ornithine cyclodeaminase	-	-	4.3.1.12	ko:K01750	ko00330,ko01110,ko01130,ko01230,map00330,map01110,map01130,map01230	-	R00671	RC00354	ko00000,ko00001,ko01000	-	-	-	OCD_Mu_crystall
REGS3_k127_28139_2	1121946.AUAX01000008_gene7312	1.723e-97	336.0	COG1129@1|root,COG1129@2|Bacteria,2I2G1@201174|Actinobacteria	201174|Actinobacteria	G	ABC transporter, ATP-binding protein	-	-	-	ko:K16786,ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran
REGS3_k127_28139_7	979556.MTES_0776	4.26e-51	193.0	COG0697@1|root,COG0697@2|Bacteria,2GMPJ@201174|Actinobacteria,4FNM1@85023|Microbacteriaceae	201174|Actinobacteria	EG	EamA-like transporter family	-	-	-	ko:K03298	-	-	-	-	ko00000,ko02000	2.A.7.3	-	-	EamA
REGS3_k127_28139_0	1313172.YM304_20080	1.164e-133	431.0	COG1024@1|root,COG1024@2|Bacteria,2GJDK@201174|Actinobacteria	2|Bacteria	I	Enoyl-CoA hydratase	MA20_16335	-	5.3.3.18	ko:K15866	ko00360,ko01120,map00360,map01120	-	R09837,R09839	RC00004,RC00326,RC02689,RC03003	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_2224	ECH_1
REGS3_k127_28139_9	222534.KB893717_gene2176	2.859e-40	162.0	COG3794@1|root,COG3794@2|Bacteria	2|Bacteria	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cupredoxin_1,Cytochrom_C
REGS3_k127_28139_6	298653.Franean1_6394	7.22e-63	220.0	COG0778@1|root,COG0778@2|Bacteria,2I94X@201174|Actinobacteria	201174|Actinobacteria	C	Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
REGS3_k127_2854698_4	1313172.YM304_41890	1.494e-115	375.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria	201174|Actinobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
REGS3_k127_2854698_3	1313172.YM304_24100	6.45e-122	396.0	COG1159@1|root,COG1159@2|Bacteria,2GJJE@201174|Actinobacteria,4CN3C@84992|Acidimicrobiia	84992|Acidimicrobiia	J	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism	era	-	-	ko:K03595	-	-	-	-	ko00000,ko03009,ko03029	-	-	-	KH_2,MMR_HSR1
REGS3_k127_2854698_10	1385520.N802_16435	0.000541	51.0	COG5401@1|root,COG5401@2|Bacteria,2IRGJ@201174|Actinobacteria	201174|Actinobacteria	S	Sporulation and spore germination	-	-	-	-	-	-	-	-	-	-	-	-	Germane
REGS3_k127_2854698_2	1313172.YM304_24120	4.759e-144	472.0	COG0642@1|root,COG2205@2|Bacteria,2GK1J@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
REGS3_k127_2854698_9	411470.RUMGNA_02374	2.733e-40	157.0	COG0745@1|root,COG0745@2|Bacteria,1TPQG@1239|Firmicutes,248Z4@186801|Clostridia,3XYMR@572511|Blautia	186801|Clostridia	T	Psort location Cytoplasmic, score 9.98	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
REGS3_k127_2854698_0	1313172.YM304_24190	1.356e-263	825.0	COG1199@1|root,COG1199@2|Bacteria,2GKT8@201174|Actinobacteria	201174|Actinobacteria	KL	helicase	dinG	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,Helicase_C_2
REGS3_k127_2854698_5	1313172.YM304_24200	1.469e-98	326.0	COG0020@1|root,COG0020@2|Bacteria,2GIXF@201174|Actinobacteria,4CN13@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	-	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
REGS3_k127_2854698_7	1313172.YM304_24210	3.547e-44	167.0	COG0020@1|root,COG0020@2|Bacteria	2|Bacteria	I	transferase activity, transferring alkyl or aryl (other than methyl) groups	MA20_23565	GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
REGS3_k127_2854698_6	1313172.YM304_24220	1.949e-88	297.0	COG1381@1|root,COG1381@2|Bacteria,2GK81@201174|Actinobacteria,4CN8K@84992|Acidimicrobiia	84992|Acidimicrobiia	L	Involved in DNA repair and RecF pathway recombination	recO	-	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
REGS3_k127_2854698_1	1313172.YM304_24260	4.723e-245	763.0	COG0423@1|root,COG0423@2|Bacteria,2GIT3@201174|Actinobacteria,4CMWI@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Catalyzes the attachment of glycine to tRNA(Gly)	glyQS	-	6.1.1.14	ko:K01880	ko00970,map00970	M00359,M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	HGTP_anticodon,tRNA-synt_2b
REGS3_k127_2854698_8	401526.TcarDRAFT_2379	1.365e-42	164.0	COG0642@1|root,COG2205@2|Bacteria,1V10X@1239|Firmicutes,4H282@909932|Negativicutes	909932|Negativicutes	T	histidine kinase HAMP region domain protein	baeS	-	2.7.13.3	ko:K07642	ko02020,map02020	M00450,M00645,M00646,M00648	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,Response_reg,dCache_1
REGS3_k127_2887730_3	1122611.KB903970_gene2624	3.246e-55	196.0	COG1073@1|root,COG1073@2|Bacteria,2I5P1@201174|Actinobacteria,4ER9W@85012|Streptosporangiales	201174|Actinobacteria	S	Dienelactone hydrolase family	-	-	-	ko:K07100	-	-	-	-	ko00000	-	-	-	DLH
REGS3_k127_2887730_2	1229780.BN381_10132	3.981e-130	423.0	COG3250@1|root,COG3250@2|Bacteria,2I952@201174|Actinobacteria	201174|Actinobacteria	G	Protein of unknown function (DUF2804)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2804
REGS3_k127_2887730_4	1160137.KB907307_gene1118	2.957e-50	195.0	COG5285@1|root,COG5285@2|Bacteria,2IC8K@201174|Actinobacteria	201174|Actinobacteria	Q	Phytanoyl-CoA dioxygenase (PhyH)	-	-	-	-	-	-	-	-	-	-	-	-	PhyH
REGS3_k127_2887730_1	994479.GL877878_gene3112	9.305e-144	477.0	COG0028@1|root,COG0028@2|Bacteria,2GKU4@201174|Actinobacteria,4E1U7@85010|Pseudonocardiales	201174|Actinobacteria	EH	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	2.2.1.6,2.5.1.66	ko:K01652,ko:K12673	ko00290,ko00331,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00331,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570,M00674	R00006,R00014,R00226,R03050,R04672,R04673,R05465,R08648	RC00027,RC00106,RC00215,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
REGS3_k127_2887730_0	1229780.BN381_350098	2.194e-170	547.0	COG1233@1|root,COG1233@2|Bacteria,2GJ80@201174|Actinobacteria,3UX4P@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	Q	FAD binding domain	p	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_8
REGS3_k127_2887730_5	1120960.ATXG01000019_gene3404	2.385e-46	182.0	COG0667@1|root,COG0667@2|Bacteria,2ID5A@201174|Actinobacteria	201174|Actinobacteria	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
REGS3_k127_2887730_6	446462.Amir_4275	1.057e-24	119.0	COG0470@1|root,COG2197@1|root,COG0470@2|Bacteria,COG2197@2|Bacteria,2IC7E@201174|Actinobacteria,4EFCC@85010|Pseudonocardiales	201174|Actinobacteria	K	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
REGS3_k127_2906073_1	1313172.YM304_39200	8.234e-233	725.0	COG0443@1|root,COG0443@2|Bacteria,2GJTY@201174|Actinobacteria,4CMVI@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
REGS3_k127_2906073_3	479434.Sthe_1507	1.419e-123	415.0	COG0477@1|root,COG2814@2|Bacteria,2G8DX@200795|Chloroflexi	200795|Chloroflexi	EGP	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
REGS3_k127_2906073_2	1313172.YM304_34120	8.17e-232	729.0	COG2866@1|root,COG2866@2|Bacteria	2|Bacteria	E	metallocarboxypeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
REGS3_k127_2906073_4	1304275.C41B8_15260	1.666e-89	301.0	COG0588@1|root,COG0588@2|Bacteria,1MUVE@1224|Proteobacteria,1RNCX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily	gpmA	GO:0003674,GO:0003824,GO:0004619,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006109,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009894,GO:0009987,GO:0010675,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019219,GO:0019220,GO:0019222,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0031323,GO:0031329,GO:0032787,GO:0034248,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0043455,GO:0043456,GO:0043470,GO:0043471,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046538,GO:0046700,GO:0046939,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051186,GO:0051188,GO:0051193,GO:0051196,GO:0055086,GO:0060255,GO:0062012,GO:0065007,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902031	5.4.2.11	ko:K01834	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	His_Phos_1
REGS3_k127_2906073_7	1229780.BN381_60087	3.92e-27	117.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	GGDEF,HTH_Crp_2,cNMP_binding
REGS3_k127_2906073_0	1313172.YM304_39270	0.0	1219.0	COG0247@1|root,COG2181@1|root,COG0247@2|Bacteria,COG2181@2|Bacteria,2GJ7M@201174|Actinobacteria,4CMWD@84992|Acidimicrobiia	84992|Acidimicrobiia	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
REGS3_k127_2906073_6	525909.Afer_0052	1.004e-76	262.0	COG0717@1|root,COG0717@2|Bacteria,2GKQQ@201174|Actinobacteria,4CMXC@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Belongs to the dCTP deaminase family	dcd	-	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	DCD
REGS3_k127_2906073_5	644283.Micau_0123	1.762e-89	302.0	COG0262@1|root,COG0262@2|Bacteria,2GYU7@201174|Actinobacteria,4DM4I@85008|Micromonosporales	201174|Actinobacteria	H	RibD C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
REGS3_k127_2911804_5	366602.Caul_2671	6.334e-59	217.0	COG0596@1|root,COG0596@2|Bacteria,1MUSF@1224|Proteobacteria,2TSK5@28211|Alphaproteobacteria,2KI1E@204458|Caulobacterales	204458|Caulobacterales	S	Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons	dhmA	-	3.8.1.5	ko:K01563	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05284,R05367,R05368,R05369,R05370,R07669,R07670	RC01317,RC01340,RC01341,RC02013	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1,Abhydrolase_6
REGS3_k127_2911804_8	316274.Haur_0755	9.086e-22	110.0	2E2BT@1|root,32XGW@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_2911804_7	298653.Franean1_4381	2.928e-30	123.0	COG0640@1|root,COG0640@2|Bacteria,2IKK2@201174|Actinobacteria,4ET2N@85013|Frankiales	201174|Actinobacteria	K	regulatory protein, arsR	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_20,HTH_5
REGS3_k127_2911804_4	1304865.JAGF01000001_gene3528	9.957e-64	222.0	COG3260@1|root,COG3260@2|Bacteria,2IDTD@201174|Actinobacteria	201174|Actinobacteria	C	NADH ubiquinone oxidoreductase, 20	hycG	-	-	-	-	-	-	-	-	-	-	-	Oxidored_q6
REGS3_k127_2911804_0	345341.KUTG_09509	4.921e-196	636.0	COG0651@1|root,COG0651@2|Bacteria,2HAC7@201174|Actinobacteria,4E1K9@85010|Pseudonocardiales	201174|Actinobacteria	CP	Proton-conducting membrane transporter	-	-	-	ko:K12137	-	-	-	-	ko00000,ko01000	-	-	-	Proton_antipo_M
REGS3_k127_2911804_3	345341.KUTG_09248	2.521e-114	378.0	COG0650@1|root,COG0650@2|Bacteria,2GJFM@201174|Actinobacteria,4E09J@85010|Pseudonocardiales	201174|Actinobacteria	C	NADH dehydrogenase	hycD	-	-	ko:K12138	-	-	-	-	ko00000,ko01000	-	-	-	NADHdh
REGS3_k127_2911804_6	1463854.JOHT01000003_gene6369	4.551e-58	214.0	COG4237@1|root,COG4237@2|Bacteria,2HQ3P@201174|Actinobacteria	201174|Actinobacteria	C	Hydrogenase 4 membrane	hycP	GO:0008150,GO:0040007	-	ko:K12140	-	-	-	-	ko00000,ko01000	-	-	-	-
REGS3_k127_2911804_1	1304865.JAGF01000001_gene3524	1.878e-131	435.0	COG0651@1|root,COG0651@2|Bacteria,2HAC7@201174|Actinobacteria	201174|Actinobacteria	CP	Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit	hycQ	-	-	ko:K12141	-	-	-	-	ko00000,ko01000	-	-	-	Proton_antipo_M
REGS3_k127_2911804_2	1137269.AZWL01000050_gene5205	4.795e-125	416.0	COG3261@1|root,COG3262@1|root,COG3261@2|Bacteria,COG3262@2|Bacteria,2GYM5@201174|Actinobacteria	201174|Actinobacteria	C	Respiratory-chain NADH dehydrogenase, 30 Kd subunit	hycE	-	-	-	-	-	-	-	-	-	-	-	Complex1_30kDa,Complex1_49kDa,NiFeSe_Hases
REGS3_k127_2920342_10	1035308.AQYY01000001_gene3642	8.072e-91	304.0	COG1180@1|root,COG1180@2|Bacteria,1TPK2@1239|Firmicutes,24871@186801|Clostridia	186801|Clostridia	C	glycyl-radical enzyme activating protein family	yjjW	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4,Fer4_12,Fer4_6,Radical_SAM
REGS3_k127_2920342_1	196162.Noca_1873	3.017e-214	677.0	COG1328@1|root,COG1328@2|Bacteria,2I5BQ@201174|Actinobacteria	201174|Actinobacteria	F	Protein of unknown function (DUF3029)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3029
REGS3_k127_2920342_3	338969.Rfer_0492	1.114e-151	510.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2VH2F@28216|Betaproteobacteria,4A9PT@80864|Comamonadaceae	28216|Betaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
REGS3_k127_2920342_11	263358.VAB18032_00625	7.958e-88	294.0	COG2197@1|root,COG2197@2|Bacteria,2GIVA@201174|Actinobacteria,4D9AV@85008|Micromonosporales	201174|Actinobacteria	T	response regulator	tcsR3	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
REGS3_k127_2920342_12	675635.Psed_5342	3.123e-76	271.0	COG1983@1|root,COG4585@1|root,COG1983@2|Bacteria,COG4585@2|Bacteria,2GJ4J@201174|Actinobacteria,4DXQC@85010|Pseudonocardiales	201174|Actinobacteria	T	Histidine kinase	tcsS3	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HATPase_c_2,PspC
REGS3_k127_2920342_17	590998.Celf_1102	2.011e-08	66.0	COG1983@1|root,COG1983@2|Bacteria,2GIVS@201174|Actinobacteria,4F19Z@85016|Cellulomonadaceae	201174|Actinobacteria	KT	PspC domain	pspC	-	-	-	-	-	-	-	-	-	-	-	DUF2154,PspC
REGS3_k127_2920342_6	1313172.YM304_23890	2.248e-123	406.0	COG0451@1|root,COG0451@2|Bacteria,2GMHH@201174|Actinobacteria	201174|Actinobacteria	M	3-beta hydroxysteroid dehydrogenase isomerase	-	GO:0000166,GO:0003674,GO:0003824,GO:0003854,GO:0004769,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006629,GO:0008150,GO:0008152,GO:0008202,GO:0016020,GO:0016229,GO:0016491,GO:0016614,GO:0016616,GO:0016853,GO:0016860,GO:0016863,GO:0030283,GO:0033764,GO:0036094,GO:0043167,GO:0043168,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0070403,GO:0071704,GO:0071944,GO:0097159,GO:1901265,GO:1901360,GO:1901363	1.1.1.145,1.1.1.412,5.3.3.1	ko:K16045,ko:K22320	ko00984,ko01120,map00984,map01120	-	R09920	RC00146	ko00000,ko00001,ko01000	-	-	-	3Beta_HSD,Epimerase
REGS3_k127_2920342_0	1313172.YM304_23880	7.227e-279	882.0	COG0318@1|root,COG2267@1|root,COG0318@2|Bacteria,COG2267@2|Bacteria,2GJR0@201174|Actinobacteria	201174|Actinobacteria	IQ	synthetase	-	-	6.1.3.1	ko:K22319	-	-	-	-	ko00000,ko01000	-	-	-	AMP-binding,Abhydrolase_1
REGS3_k127_2920342_4	1313172.YM304_23870	1.507e-145	470.0	COG0332@1|root,COG0332@2|Bacteria,2I9C8@201174|Actinobacteria	201174|Actinobacteria	I	synthase III	-	-	2.3.1.180	ko:K00648,ko:K22317	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
REGS3_k127_2920342_7	58344.JOEL01000006_gene4747	2.452e-119	387.0	COG1834@1|root,COG1834@2|Bacteria,2GNTN@201174|Actinobacteria	201174|Actinobacteria	E	amidinotransferase	ddaH	-	3.5.3.18	ko:K01482	-	-	-	-	ko00000,ko01000,ko04147	-	-	-	Amidinotransf
REGS3_k127_2920342_13	1313172.YM304_11240	4.871e-68	241.0	COG1024@1|root,COG1024@2|Bacteria,2GJ0N@201174|Actinobacteria,4CNYM@84992|Acidimicrobiia	201174|Actinobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.17,4.2.1.18	ko:K01692,ko:K13766	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00036,M00087	R02085,R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115,RC02416	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
REGS3_k127_2920342_9	1123320.KB889562_gene6806	1.414e-111	377.0	COG2141@1|root,COG2141@2|Bacteria,2GNE9@201174|Actinobacteria	201174|Actinobacteria	C	F420-dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
REGS3_k127_2920342_8	1265310.CCBD010000015_gene3582	3.01e-113	378.0	COG0604@1|root,COG0604@2|Bacteria,2I66C@201174|Actinobacteria,237CB@1762|Mycobacteriaceae	201174|Actinobacteria	C	Protein of unknown function (DUF2855)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2855
REGS3_k127_2920342_14	326424.FRAAL3254	2.229e-67	236.0	COG5514@1|root,COG5514@2|Bacteria,2IS68@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF1794)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1794
REGS3_k127_2920342_5	1287116.X734_13820	1.471e-127	425.0	COG3119@1|root,COG3119@2|Bacteria,1MV0B@1224|Proteobacteria,2TRI6@28211|Alphaproteobacteria,43HVG@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	Sulfatase	pehA	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
REGS3_k127_2920342_15	1111479.AXAR01000002_gene1935	1.236e-30	132.0	COG1024@1|root,COG1024@2|Bacteria,1TQ89@1239|Firmicutes,4HB73@91061|Bacilli	91061|Bacilli	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	-	ECH_1
REGS3_k127_2920342_2	1123320.KB889562_gene6741	6.28e-152	485.0	COG1028@1|root,COG1028@2|Bacteria,2GK20@201174|Actinobacteria	201174|Actinobacteria	IQ	Short-chain dehydrogenase reductase sdr	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
REGS3_k127_2920342_16	1415166.NONO_c61450	4.388e-25	106.0	COG3653@1|root,COG3653@2|Bacteria,2GKMK@201174|Actinobacteria,4FUZR@85025|Nocardiaceae	201174|Actinobacteria	Q	COG3653 N-acyl-D-aspartate D-glutamate deacylase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
REGS3_k127_2982217_1	1160718.SU9_03486	1.036e-77	267.0	COG0745@1|root,COG0745@2|Bacteria,2GKJK@201174|Actinobacteria	201174|Actinobacteria	T	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	tcsR4	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
REGS3_k127_2982217_0	1429046.RR21198_4076	3.701e-110	372.0	COG0642@1|root,COG0642@2|Bacteria,2I2VJ@201174|Actinobacteria,4G9YW@85025|Nocardiaceae	201174|Actinobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
REGS3_k127_2982217_2	1192034.CAP_6285	2.718e-20	99.0	COG3055@1|root,COG3055@2|Bacteria	2|Bacteria	G	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses	-	-	-	-	-	-	-	-	-	-	-	-	Kelch_4
REGS3_k127_2995018_22	1313172.YM304_23810	3.234e-10	61.0	2DPAW@1|root,331AG@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4262)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4262
REGS3_k127_2995018_9	1313172.YM304_23800	6.558e-137	444.0	COG3173@1|root,COG3173@2|Bacteria,2I8YI@201174|Actinobacteria	201174|Actinobacteria	S	Aminoglycoside phosphotransferase	-	-	-	-	-	-	-	-	-	-	-	-	APH,EcKinase
REGS3_k127_2995018_12	402881.Plav_2677	5.697e-104	352.0	COG5285@1|root,COG5285@2|Bacteria,1QRDD@1224|Proteobacteria,2U0EC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Protein involved in biosynthesis of mitomycin antibiotics polyketide fumonisin	-	-	-	-	-	-	-	-	-	-	-	-	PhyH
REGS3_k127_2995018_18	1313172.YM304_23790	2.774e-48	184.0	COG3346@1|root,COG3346@2|Bacteria,2GR90@201174|Actinobacteria	201174|Actinobacteria	S	SURF1-like protein	-	GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0051704,GO:0071944	-	-	-	-	-	-	-	-	-	-	SURF1
REGS3_k127_2995018_8	1313172.YM304_23770	1.126e-140	452.0	COG0491@1|root,COG0491@2|Bacteria,2HFVZ@201174|Actinobacteria,4CN71@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Metallo-beta-lactamase superfamily	-	-	-	ko:K05555	ko01057,ko01130,map01057,map01130	M00778	R09305	-	ko00000,ko00001,ko00002,ko01000,ko01008	-	-	-	Lactamase_B
REGS3_k127_2995018_17	525909.Afer_1306	8.968e-64	229.0	COG0667@1|root,COG0667@2|Bacteria,2ICY2@201174|Actinobacteria,4CNT7@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
REGS3_k127_2995018_11	929712.KI912613_gene201	9.939e-109	369.0	COG2303@1|root,COG2303@2|Bacteria,2GJAU@201174|Actinobacteria,4CS63@84995|Rubrobacteria	84995|Rubrobacteria	E	GMC oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N
REGS3_k127_2995018_16	1313172.YM304_23740	3.599e-67	236.0	COG0406@1|root,COG0406@2|Bacteria,2IAPP@201174|Actinobacteria	201174|Actinobacteria	G	Histidine phosphatase superfamily (branch 1)	-	-	5.4.2.12	ko:K15634	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
REGS3_k127_2995018_1	1313172.YM304_23650	7.286e-240	752.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,2GKVS@201174|Actinobacteria,4CNDM@84992|Acidimicrobiia	84992|Acidimicrobiia	F	IMP dehydrogenase / GMP reductase domain	-	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
REGS3_k127_2995018_0	1313172.YM304_23520	4.222e-267	827.0	COG3552@1|root,COG3825@1|root,COG3552@2|Bacteria,COG3825@2|Bacteria,2GNTS@201174|Actinobacteria,4CMU1@84992|Acidimicrobiia	84992|Acidimicrobiia	S	VWA domain containing CoxE-like protein	-	-	-	ko:K07161	-	-	-	-	ko00000	-	-	-	VWA_CoxE
REGS3_k127_2995018_7	1313172.YM304_23510	8.083e-145	463.0	COG0714@1|root,COG0714@2|Bacteria,2GMM2@201174|Actinobacteria,4CMT3@84992|Acidimicrobiia	84992|Acidimicrobiia	O	AAA domain (dynein-related subfamily)	-	-	-	-	-	-	-	-	-	-	-	-	AAA_5
REGS3_k127_2995018_13	1229780.BN381_10215	1.161e-94	340.0	COG0464@1|root,COG0464@2|Bacteria,2GJWA@201174|Actinobacteria	201174|Actinobacteria	O	AAA ATPase central domain protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA
REGS3_k127_2995018_4	1229780.BN381_10212	2.063e-177	577.0	COG2304@1|root,COG2304@2|Bacteria,2HQ9B@201174|Actinobacteria,3UXG6@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	Von Willebrand factor, type A	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_11
REGS3_k127_2995018_19	1313172.YM304_23470	6.254e-47	180.0	2CIFA@1|root,348QY@2|Bacteria,2H88E@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_2995018_5	1313172.YM304_23460	1.455e-162	527.0	COG0728@1|root,COG0728@2|Bacteria,2GKN0@201174|Actinobacteria,4CN0A@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Polysaccharide biosynthesis C-terminal domain	-	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
REGS3_k127_2995018_15	1313172.YM304_23450	2.597e-89	301.0	COG1842@1|root,COG1842@2|Bacteria,2GJGD@201174|Actinobacteria	201174|Actinobacteria	KT	Phage shock protein A	pspA	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044464,GO:0071944	-	ko:K03969	-	-	-	-	ko00000	-	-	-	PspA_IM30
REGS3_k127_2995018_10	1313172.YM304_23440	2.214e-118	390.0	COG0263@1|root,COG0263@2|Bacteria,2GM8U@201174|Actinobacteria,4CMY3@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate	proB	-	2.7.2.11	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	M00015	R00239	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,PUA
REGS3_k127_2995018_3	1313172.YM304_23430	2.78e-202	639.0	COG0536@1|root,COG0536@2|Bacteria,2GISB@201174|Actinobacteria,4CMVB@84992|Acidimicrobiia	84992|Acidimicrobiia	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	DUF1967,GTP1_OBG,MMR_HSR1
REGS3_k127_2995018_6	1313172.YM304_23420	2.853e-149	482.0	COG0232@1|root,COG0232@2|Bacteria,2GJ8F@201174|Actinobacteria,4CMVC@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Phosphohydrolase-associated domain	-	-	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	-	HD,HD_assoc
REGS3_k127_2995018_21	1313172.YM304_18470	8.587e-34	131.0	COG0211@1|root,COG0211@2|Bacteria,2IQDI@201174|Actinobacteria,4CN91@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Ribosomal L27 protein	rpmA	-	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
REGS3_k127_2995018_20	1313172.YM304_18460	3.317e-40	151.0	COG0261@1|root,COG0261@2|Bacteria,2IQ9A@201174|Actinobacteria,4CN9R@84992|Acidimicrobiia	84992|Acidimicrobiia	J	This protein binds to 23S rRNA in the presence of protein L20	rplU	-	-	ko:K02888	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21p
REGS3_k127_2995018_2	1313172.YM304_18440	8.751e-233	741.0	COG1530@1|root,COG1530@2|Bacteria,2GMM5@201174|Actinobacteria,4CMPW@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Ribonuclease E/G family	-	-	3.1.26.12	ko:K08300,ko:K08301	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	-	-	-	RNase_E_G
REGS3_k127_2995018_14	1313172.YM304_18400	2.895e-92	308.0	COG0772@1|root,COG0772@2|Bacteria,2GK2G@201174|Actinobacteria,4CN2U@84992|Acidimicrobiia	84992|Acidimicrobiia	D	Cell cycle protein	-	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
REGS3_k127_3013604_1	1313172.YM304_32120	1.01e-203	647.0	COG0477@1|root,COG0477@2|Bacteria,2GIUM@201174|Actinobacteria,4CNFR@84992|Acidimicrobiia	84992|Acidimicrobiia	U	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
REGS3_k127_3013604_9	1343740.M271_47530	6.663e-90	301.0	COG0412@1|root,COG0412@2|Bacteria,2HVNP@201174|Actinobacteria	201174|Actinobacteria	Q	dienelactone hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	DLH
REGS3_k127_3013604_7	446462.Amir_2635	3.455e-130	424.0	COG0604@1|root,COG0604@2|Bacteria,2ID9Y@201174|Actinobacteria,4EBBE@85010|Pseudonocardiales	201174|Actinobacteria	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
REGS3_k127_3013604_11	743718.Isova_0973	4.76e-66	235.0	COG0274@1|root,COG0274@2|Bacteria,2GJIR@201174|Actinobacteria,4F39G@85017|Promicromonosporaceae	201174|Actinobacteria	F	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate	deoC	-	4.1.2.4	ko:K01619	ko00030,map00030	-	R01066	RC00436,RC00437	ko00000,ko00001,ko01000	-	-	-	DeoC
REGS3_k127_3013604_5	471852.Tcur_4189	3.673e-172	550.0	COG0213@1|root,COG0213@2|Bacteria,2GJH5@201174|Actinobacteria,4EG7W@85012|Streptosporangiales	201174|Actinobacteria	F	Pyrimidine nucleoside phosphorylase C-terminal domain	deoA	GO:0003674,GO:0003824,GO:0004645,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0009032,GO:0016740,GO:0016757,GO:0016758,GO:0016763,GO:0044424,GO:0044444,GO:0044464	2.4.2.2,2.4.2.4	ko:K00756,ko:K00758	ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219	-	R01570,R01876,R02296,R02484,R08222,R08230	RC00063	ko00000,ko00001,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3,PYNP_C
REGS3_k127_3013604_13	767029.HMPREF9154_1441	1.296e-56	209.0	COG0803@1|root,COG0803@2|Bacteria,2GM1K@201174|Actinobacteria,4DNM9@85009|Propionibacteriales	201174|Actinobacteria	P	Zinc-uptake complex component A periplasmic	-	-	-	ko:K09815	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ZnuA
REGS3_k127_3013604_14	479434.Sthe_2976	5.939e-52	195.0	COG1121@1|root,COG1121@2|Bacteria,2G7X2@200795|Chloroflexi,27XH6@189775|Thermomicrobia	189775|Thermomicrobia	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K09820	-	M00243	-	-	ko00000,ko00002,ko02000	3.A.1.15	-	-	ABC_tran
REGS3_k127_3013604_15	1121377.KB906398_gene2271	2.053e-45	181.0	COG1108@1|root,COG1108@2|Bacteria	2|Bacteria	P	ABC-type Mn2 Zn2 transport systems permease components	mntB	-	-	ko:K02075,ko:K09819	-	M00243,M00244	-	-	ko00000,ko00002,ko02000	3.A.1.15	-	-	ABC-3
REGS3_k127_3013604_6	1123024.AUII01000003_gene3482	6.314e-153	493.0	COG1680@1|root,COG1680@2|Bacteria,2H2SY@201174|Actinobacteria,4DXGA@85010|Pseudonocardiales	201174|Actinobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
REGS3_k127_3013604_8	1313172.YM304_41850	2.951e-93	312.0	COG1028@1|root,COG1028@2|Bacteria,2GWHQ@201174|Actinobacteria	201174|Actinobacteria	IQ	short-chain dehydrogenase reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
REGS3_k127_3013604_10	1313172.YM304_28950	4.279e-84	284.0	COG0560@1|root,COG0560@2|Bacteria,2H4ZQ@201174|Actinobacteria	201174|Actinobacteria	E	haloacid dehalogenase-like hydrolase	-	-	2.7.1.39,3.1.3.3	ko:K02203	ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00680,map01100,map01110,map01120,map01130,map01230	M00018	R00582,R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HAD
REGS3_k127_3013604_0	426716.JOAJ01000001_gene692	3.64e-234	748.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,2GK8E@201174|Actinobacteria,4FXE3@85025|Nocardiaceae	201174|Actinobacteria	C	NADH:flavin oxidoreductase / NADH oxidase family	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN,Pyr_redox_2
REGS3_k127_3013604_2	1211815.CBYP010000068_gene194	2.223e-198	635.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria	201174|Actinobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
REGS3_k127_3013604_3	1394178.AWOO02000043_gene5908	5.634e-177	565.0	COG1249@1|root,COG1249@2|Bacteria,2GIXY@201174|Actinobacteria,4EG91@85012|Streptosporangiales	201174|Actinobacteria	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	-	-	1.8.1.15,1.8.1.4	ko:K00382,ko:K17883	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
REGS3_k127_3013604_4	2045.KR76_14285	1.163e-176	560.0	COG0183@1|root,COG0183@2|Bacteria,2GJ0W@201174|Actinobacteria,4DNM2@85009|Propionibacteriales	201174|Actinobacteria	I	Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation	ltp3	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	-
REGS3_k127_3013604_12	1278073.MYSTI_04818	7.745e-58	205.0	COG0183@1|root,COG0183@2|Bacteria,1PSXC@1224|Proteobacteria	1224|Proteobacteria	I	Belongs to the thiolase family	-	-	-	-	-	-	-	-	-	-	-	-	Thiolase_C
REGS3_k127_3030336_17	1380390.JIAT01000015_gene5676	4.055e-49	185.0	COG3305@1|root,COG3305@2|Bacteria,2GNU5@201174|Actinobacteria,4CR11@84995|Rubrobacteria	84995|Rubrobacteria	S	Predicted membrane protein (DUF2127)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2127
REGS3_k127_3030336_5	208439.AJAP_05790	2.025e-121	399.0	COG3491@1|root,COG3491@2|Bacteria,2GT52@201174|Actinobacteria,4E49D@85010|Pseudonocardiales	201174|Actinobacteria	C	non-haem dioxygenase in morphine synthesis N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	2OG-FeII_Oxy,DIOX_N
REGS3_k127_3030336_9	1121939.L861_23595	4.754e-109	365.0	COG2175@1|root,COG2175@2|Bacteria,1MX7P@1224|Proteobacteria,1S1JW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	taurine catabolism dioxygenase	-	-	1.14.11.1	ko:K00471	ko00310,map00310	-	R02397	RC00709	ko00000,ko00001,ko01000	-	-	-	DUF971,TauD
REGS3_k127_3030336_14	909943.HIMB100_00000060	6.479e-84	282.0	COG4341@1|root,COG4341@2|Bacteria,1QHQD@1224|Proteobacteria,2U0VM@28211|Alphaproteobacteria,4BQBG@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	HD phosphohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HD,MIOX
REGS3_k127_3030336_1	1313172.YM304_09510	1.089e-151	493.0	COG3670@1|root,COG3670@2|Bacteria,2GK7D@201174|Actinobacteria	201174|Actinobacteria	Q	dioxygenase	-	GO:0003674,GO:0003824,GO:0006629,GO:0006720,GO:0006721,GO:0008150,GO:0008152,GO:0008300,GO:0009056,GO:0009987,GO:0010436,GO:0016042,GO:0016108,GO:0016110,GO:0016115,GO:0016116,GO:0016118,GO:0016491,GO:0016701,GO:0016702,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0051213,GO:0055114,GO:0071704,GO:1901575	-	ko:K11159	-	-	-	-	ko00000	-	-	-	RPE65
REGS3_k127_3030336_13	1434929.X946_727	5.562e-97	334.0	COG1070@1|root,COG1070@2|Bacteria,1MW4A@1224|Proteobacteria,2VPTU@28216|Betaproteobacteria,1KDJU@119060|Burkholderiaceae	28216|Betaproteobacteria	G	FGGY family of carbohydrate kinase, N-terminal domain protein	xylB2	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
REGS3_k127_3030336_4	1122132.AQYH01000010_gene4257	9.094e-126	408.0	COG0388@1|root,COG0388@2|Bacteria,1MXG5@1224|Proteobacteria,2TVCS@28211|Alphaproteobacteria,4BDES@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Carbon-nitrogen hydrolase	aguB	-	3.5.1.53	ko:K12251	ko00330,ko01100,map00330,map01100	-	R01152	RC00096	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase
REGS3_k127_3030336_10	105425.BBPL01000092_gene8153	1.112e-105	353.0	COG2957@1|root,COG2957@2|Bacteria,2GJ7U@201174|Actinobacteria,2NFGK@228398|Streptacidiphilus	201174|Actinobacteria	E	Porphyromonas-type peptidyl-arginine deiminase	-	-	3.5.3.12	ko:K10536	ko00330,ko01100,map00330,map01100	-	R01416	RC00177	ko00000,ko00001,ko01000	-	-	-	PAD_porph
REGS3_k127_3030336_12	247633.GP2143_09295	2.385e-100	342.0	COG0154@1|root,COG0154@2|Bacteria,1MW3Z@1224|Proteobacteria,1RP33@1236|Gammaproteobacteria,1J6AR@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	COG0154 Asp-tRNAAsn Glu-tRNAGln amidotransferase A subunit and related amidases	-	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
REGS3_k127_3030336_15	1128421.JAGA01000003_gene3419	9.883e-79	283.0	COG2141@1|root,COG2141@2|Bacteria,2NQM2@2323|unclassified Bacteria	2|Bacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
REGS3_k127_3030336_3	1077972.ARGLB_083_00560	2.538e-130	419.0	COG0640@1|root,COG3832@1|root,COG0640@2|Bacteria,COG3832@2|Bacteria,2GNW2@201174|Actinobacteria,1WADX@1268|Micrococcaceae	201174|Actinobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1,HTH_20
REGS3_k127_3030336_11	1313172.YM304_16830	2.039e-101	338.0	COG1215@1|root,COG1215@2|Bacteria,2GMKV@201174|Actinobacteria,4CNU7@84992|Acidimicrobiia	84992|Acidimicrobiia	M	Glycosyltransferase like family 2	gpgS	-	2.4.1.266	ko:K13693	-	-	-	-	ko00000,ko01000,ko01003	-	GT81	-	Glycos_transf_2
REGS3_k127_3030336_8	1313172.YM304_16850	4.339e-111	363.0	COG0294@1|root,COG0294@2|Bacteria,2GJDQ@201174|Actinobacteria,4CNEH@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	-	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
REGS3_k127_3030336_6	1313172.YM304_16820	7.338e-114	376.0	COG0801@1|root,COG1539@1|root,COG0801@2|Bacteria,COG1539@2|Bacteria,2H3G6@201174|Actinobacteria,4CN7Q@84992|Acidimicrobiia	84992|Acidimicrobiia	H	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)	-	-	2.7.6.3,4.1.2.25	ko:K00950,ko:K13940	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503,R03504	RC00002,RC00017,RC00721,RC00943	ko00000,ko00001,ko00002,ko01000	-	-	-	HPPK
REGS3_k127_3030336_16	1313172.YM304_36480	8.649e-52	194.0	COG1295@1|root,COG1295@2|Bacteria,2HG9R@201174|Actinobacteria,4CN87@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Virulence factor BrkB	-	-	-	-	-	-	-	-	-	-	-	-	Virul_fac_BrkB
REGS3_k127_3030336_2	1229780.BN381_10242	3.862e-134	461.0	COG0559@1|root,COG4177@1|root,COG0559@2|Bacteria,COG4177@2|Bacteria,2GJHR@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,BCA_ABC_TP_C,BPD_transp_2
REGS3_k127_3030336_0	1229780.BN381_10243	1.745e-317	1000.0	COG0410@1|root,COG0411@1|root,COG0410@2|Bacteria,COG0411@2|Bacteria,2GMEE@201174|Actinobacteria	201174|Actinobacteria	E	ABC transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
REGS3_k127_3030336_7	1229780.BN381_10244	2.441e-113	386.0	2FACV@1|root,342M7@2|Bacteria,2H6AW@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_3030336_18	1500301.JQMF01000002_gene739	3.236e-13	69.0	COG0692@1|root,COG0692@2|Bacteria,1MV80@1224|Proteobacteria,2U1VI@28211|Alphaproteobacteria,4B9C5@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine	ung	-	3.2.2.27	ko:K03648	ko03410,ko05340,map03410,map05340	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
REGS3_k127_3090725_8	44454.NF84_21780	2.884e-65	230.0	COG1024@1|root,COG1024@2|Bacteria,2HEIS@201174|Actinobacteria,237CX@1762|Mycobacteriaceae	201174|Actinobacteria	I	Enoyl-CoA hydratase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
REGS3_k127_3090725_4	1313172.YM304_27100	2.268e-85	288.0	2BZNP@1|root,30717@2|Bacteria,2IAEK@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF2889)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2889
REGS3_k127_3090725_6	591158.SSMG_01937	7.411e-71	252.0	COG1960@1|root,COG1960@2|Bacteria,2GITF@201174|Actinobacteria	201174|Actinobacteria	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_N
REGS3_k127_3090725_0	1229780.BN381_400017	3.512e-177	566.0	COG1960@1|root,COG1960@2|Bacteria,2GIXS@201174|Actinobacteria	201174|Actinobacteria	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
REGS3_k127_3090725_2	1229780.BN381_10333	2.41e-123	410.0	COG1804@1|root,COG1804@2|Bacteria,2GKNX@201174|Actinobacteria,3UWNW@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	CoA-transferase family III	-	-	5.1.99.4	ko:K01796	ko00120,ko01100,ko04146,map00120,map01100,map04146	M00104	R08734,R08739	RC02345	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_transf_3
REGS3_k127_3090725_13	1122609.AUGT01000026_gene4	9.813e-23	107.0	COG5517@1|root,COG5517@2|Bacteria,2IFNT@201174|Actinobacteria,4DRVW@85009|Propionibacteriales	201174|Actinobacteria	Q	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_4
REGS3_k127_3090725_14	1123320.KB889750_gene8526	8.822e-15	82.0	COG1028@1|root,COG1028@2|Bacteria,2IMM5@201174|Actinobacteria	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
REGS3_k127_3090725_10	1123320.KB889750_gene8525	3.673e-52	199.0	COG1028@1|root,COG1028@2|Bacteria,2IJC8@201174|Actinobacteria	201174|Actinobacteria	IQ	KR domain	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
REGS3_k127_3090725_12	1229780.BN381_90007	3.87e-24	105.0	2EKZY@1|root,33EPF@2|Bacteria,2H1IF@201174|Actinobacteria	201174|Actinobacteria	S	EthD domain	-	-	-	-	-	-	-	-	-	-	-	-	EthD
REGS3_k127_3090725_11	1499680.CCFE01000022_gene2354	4.468e-51	188.0	COG1670@1|root,COG1670@2|Bacteria,1V5BA@1239|Firmicutes,4HHR5@91061|Bacilli,1ZG8F@1386|Bacillus	91061|Bacilli	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
REGS3_k127_3090725_9	561175.KB894094_gene1776	2.526e-54	198.0	COG1335@1|root,COG1335@2|Bacteria,2I81Y@201174|Actinobacteria,4EINJ@85012|Streptosporangiales	201174|Actinobacteria	Q	Isochorismatase family	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
REGS3_k127_3090725_7	1123320.KB889685_gene2189	2.879e-69	244.0	28K5H@1|root,2Z9U4@2|Bacteria,2GKEQ@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_3090725_5	1123320.KB889665_gene1469	2.526e-79	276.0	COG0451@1|root,COG0451@2|Bacteria,2I9DG@201174|Actinobacteria	201174|Actinobacteria	GM	Epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
REGS3_k127_3090725_3	1120936.KB907210_gene5519	1.747e-101	340.0	COG2141@1|root,COG2141@2|Bacteria,2GMMJ@201174|Actinobacteria,4EGKE@85012|Streptosporangiales	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
REGS3_k127_3090725_1	1122939.ATUD01000004_gene3874	1.409e-164	537.0	COG0488@1|root,COG0488@2|Bacteria,2GMUD@201174|Actinobacteria	201174|Actinobacteria	S	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
REGS3_k127_3090725_15	1242864.D187_009734	1.375e-12	72.0	COG0504@1|root,COG0504@2|Bacteria,1QBV2@1224|Proteobacteria,43A2I@68525|delta/epsilon subdivisions,2X20W@28221|Deltaproteobacteria,2YZU3@29|Myxococcales	28221|Deltaproteobacteria	F	Glutamine amidotransferase class-I	-	-	-	-	-	-	-	-	-	-	-	-	GATase
REGS3_k127_3206005_17	1313172.YM304_39810	3.714e-38	148.0	COG1403@1|root,COG1403@2|Bacteria,2GVP9@201174|Actinobacteria	201174|Actinobacteria	V	Domain of unknown function (DUF222)	-	-	-	-	-	-	-	-	-	-	-	-	DUF222
REGS3_k127_3206005_19	525909.Afer_0695	7.241e-35	143.0	COG3576@1|root,COG3576@2|Bacteria,2II3S@201174|Actinobacteria,4CNCN@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Pfam:Pyridox_oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
REGS3_k127_3206005_15	1313172.YM304_13310	3.548e-49	189.0	COG3651@1|root,COG3651@2|Bacteria,2IHNI@201174|Actinobacteria	201174|Actinobacteria	S	protein conserved in bacteria	-	-	-	ko:K09966	-	-	-	-	ko00000	-	-	-	DUF2237
REGS3_k127_3206005_6	1032480.MLP_26650	2.076e-158	516.0	COG2185@1|root,COG2185@2|Bacteria	2|Bacteria	I	cobalamin binding	mgm	-	5.4.99.4	ko:K20450	ko00760,ko01120,map00760,map01120	-	R03908	RC01024	ko00000,ko00001,ko01000	-	-	-	B12-binding
REGS3_k127_3206005_8	1229780.BN381_40064	6.671e-123	411.0	COG1894@1|root,COG1894@2|Bacteria,2GNN9@201174|Actinobacteria,3UXSE@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	nuoF_1	-	-	-	-	-	-	-	-	-	-	-	Complex1_51K,NADH_4Fe-4S
REGS3_k127_3206005_7	525909.Afer_1526	4.933e-152	489.0	COG1960@1|root,COG1960@2|Bacteria,2GIX8@201174|Actinobacteria,4CNIG@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.4	ko:K00253	ko00280,ko01100,map00280,map01100	M00036	R04095	RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
REGS3_k127_3206005_14	1313172.YM304_13050	1.382e-56	204.0	2F7CY@1|root,33ZTZ@2|Bacteria,2H76P@201174|Actinobacteria,4CNCM@84992|Acidimicrobiia	84992|Acidimicrobiia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_3206005_1	1313172.YM304_13020	5.798e-265	826.0	COG0119@1|root,COG0119@2|Bacteria,2GKYT@201174|Actinobacteria,4CMUV@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Belongs to the alpha-IPM synthase homocitrate synthase family	-	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
REGS3_k127_3206005_4	1313172.YM304_13000	2.05e-176	556.0	COG0115@1|root,COG0115@2|Bacteria,2GKJ1@201174|Actinobacteria,4CMVG@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
REGS3_k127_3206005_5	1313172.YM304_12990	3.606e-174	554.0	COG0473@1|root,COG0473@2|Bacteria,2GK44@201174|Actinobacteria,4CMRK@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Isocitrate/isopropylmalate dehydrogenase	leuB	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
REGS3_k127_3206005_16	1313172.YM304_12970	3.654e-46	171.0	COG0782@1|root,COG0782@2|Bacteria,2GNZV@201174|Actinobacteria,4CN6V@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	-	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
REGS3_k127_3206005_9	1313172.YM304_12960	2.849e-107	354.0	COG2267@1|root,COG2267@2|Bacteria,2I79Z@201174|Actinobacteria	201174|Actinobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
REGS3_k127_3206005_3	1313172.YM304_12950	1.608e-194	620.0	COG0661@1|root,COG0661@2|Bacteria,2GJQ6@201174|Actinobacteria,4CMRN@84992|Acidimicrobiia	84992|Acidimicrobiia	S	ABC1 family	-	-	-	-	-	-	-	-	-	-	-	-	ABC1
REGS3_k127_3206005_0	1313172.YM304_01730	0.0	1130.0	COG0506@1|root,COG1012@1|root,COG0506@2|Bacteria,COG1012@2|Bacteria,2GM5R@201174|Actinobacteria,4CNNB@84992|Acidimicrobiia	84992|Acidimicrobiia	CE	Proline dehydrogenase	-	-	1.2.1.88,1.5.5.2	ko:K13821	ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130	-	R00245,R00707,R00708,R01253,R04444,R04445,R05051	RC00080,RC00083,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000,ko03000	-	-	-	Aldedh,Pro_dh
REGS3_k127_3206005_13	1313172.YM304_01740	1.76e-67	238.0	COG2207@1|root,COG2207@2|Bacteria,2HGPN@201174|Actinobacteria,4CNRY@84992|Acidimicrobiia	84992|Acidimicrobiia	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18,PAS_4
REGS3_k127_3206005_18	66869.JNXG01000017_gene4898	2.352e-35	147.0	COG0545@1|root,COG0545@2|Bacteria,2GJK2@201174|Actinobacteria,41A4G@629295|Streptomyces griseus group	201174|Actinobacteria	O	FKBP-type peptidyl-prolyl cis-trans isomerase	fkbB	-	5.2.1.8	ko:K01802	-	-	-	-	ko00000,ko01000	-	-	-	FKBP_C
REGS3_k127_3206005_12	1313172.YM304_12870	3.889e-73	252.0	COG1414@1|root,COG1414@2|Bacteria,2HGKQ@201174|Actinobacteria,4CP2Q@84992|Acidimicrobiia	84992|Acidimicrobiia	K	helix_turn_helix isocitrate lyase regulation	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR
REGS3_k127_3206005_2	1313172.YM304_12860	4.712e-248	782.0	COG0065@1|root,COG0065@2|Bacteria,2GKT7@201174|Actinobacteria,4CMTC@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
REGS3_k127_3206005_10	1313172.YM304_12850	4.506e-86	296.0	COG0066@1|root,COG0066@2|Bacteria,2GJ8Z@201174|Actinobacteria,4CN17@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
REGS3_k127_3206005_11	1313172.YM304_12770	1.61e-77	263.0	COG0513@1|root,COG0513@2|Bacteria,2GIUR@201174|Actinobacteria,4CNI4@84992|Acidimicrobiia	201174|Actinobacteria	JKL	DEAD-like helicases superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DEAD,Helicase_C
REGS3_k127_3228809_4	1123320.KB889674_gene4179	1.504e-11	66.0	2EMGF@1|root,33F55@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_3228809_0	1121946.AUAX01000007_gene2773	2.304e-145	466.0	2C1EG@1|root,2Z7MZ@2|Bacteria,2GK4W@201174|Actinobacteria,4DHRJ@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_3228809_2	1313172.YM304_27260	4.557e-102	351.0	COG1218@1|root,COG1218@2|Bacteria,2GMW7@201174|Actinobacteria	201174|Actinobacteria	P	inositol monophosphatase	-	-	3.1.3.7	ko:K01082	ko00920,ko01100,ko01120,ko01130,map00920,map01100,map01120,map01130	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	Inositol_P
REGS3_k127_3228809_1	1313172.YM304_27270	2.625e-109	361.0	COG1024@1|root,COG1024@2|Bacteria,2GJDK@201174|Actinobacteria	201174|Actinobacteria	I	Enoyl-CoA hydratase	echA12_1	-	-	-	-	-	-	-	-	-	-	-	ECH_1
REGS3_k127_3228809_3	1127134.NOCYR_2782	3.963e-70	253.0	2C56P@1|root,2ZJ2W@2|Bacteria,2IKDI@201174|Actinobacteria,4G0AJ@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_3321496_7	1313172.YM304_24470	1.768e-45	166.0	COG0493@1|root,COG0493@2|Bacteria,2GJ0A@201174|Actinobacteria,4CMR7@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
REGS3_k127_3321496_8	1499684.CCNP01000020_gene2547	1.654e-09	68.0	COG1388@1|root,COG3757@1|root,COG1388@2|Bacteria,COG3757@2|Bacteria,1V484@1239|Firmicutes,24A8T@186801|Clostridia,36FZK@31979|Clostridiaceae	186801|Clostridia	M	family 25	lyc2	GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	3.2.1.17	ko:K01185,ko:K07273	-	-	-	-	ko00000,ko01000	-	-	-	CW_binding_1,Glyco_hydro_25,LysM,PG_binding_1,SH3_3
REGS3_k127_3321496_5	479435.Kfla_5854	2.477e-67	236.0	COG1670@1|root,COG1670@2|Bacteria,2GP87@201174|Actinobacteria,4DQYP@85009|Propionibacteriales	201174|Actinobacteria	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
REGS3_k127_3321496_4	1313172.YM304_34220	7.482e-77	268.0	COG0346@1|root,COG0346@2|Bacteria,2H7KR@201174|Actinobacteria	201174|Actinobacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase_3
REGS3_k127_3321496_3	1313172.YM304_22230	2.178e-128	418.0	COG0204@1|root,COG0204@2|Bacteria,2IAXZ@201174|Actinobacteria,4CN1J@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Phosphate acyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase
REGS3_k127_3321496_1	1313172.YM304_22240	3.103e-261	817.0	COG3875@1|root,COG3875@2|Bacteria,2IAM4@201174|Actinobacteria,4CMV3@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
REGS3_k127_3321496_2	1313172.YM304_22250	2.275e-170	546.0	COG1063@1|root,COG1063@2|Bacteria,2IBQC@201174|Actinobacteria,4CMYA@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Alcohol dehydrogenase GroES-like domain	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
REGS3_k127_3321496_0	1313172.YM304_22260	0.0	1149.0	COG0560@1|root,COG3320@1|root,COG0560@2|Bacteria,COG3320@2|Bacteria,2GJVX@201174|Actinobacteria,4CMQQ@84992|Acidimicrobiia	84992|Acidimicrobiia	EQ	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD,NAD_binding_4
REGS3_k127_3321496_6	1313172.YM304_22270	2.428e-49	179.0	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	-	-	-	ko:K09017	-	-	-	-	ko00000,ko03000	-	-	-	TetR_N
REGS3_k127_3338921_9	36809.MAB_4084c	1.112e-10	64.0	COG1396@1|root,COG1396@2|Bacteria,2IKVI@201174|Actinobacteria,2398E@1762|Mycobacteriaceae	201174|Actinobacteria	K	transcriptional	-	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	HTH_3,HTH_31
REGS3_k127_3338921_3	1313172.YM304_37910	5.74e-44	165.0	2DP8R@1|root,32UKH@2|Bacteria	2|Bacteria	-	-	amfC	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_3338921_7	1313172.YM304_37920	9.594e-23	99.0	COG1977@1|root,COG1977@2|Bacteria	2|Bacteria	H	Mo-molybdopterin cofactor metabolic process	moaD	-	2.8.1.12	ko:K03636,ko:K21142	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoaE,ThiS
REGS3_k127_3338921_2	1229780.BN381_60053	4.403e-47	176.0	COG0406@1|root,COG0406@2|Bacteria,2GJ9R@201174|Actinobacteria,3UWZM@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	G	Belongs to the phosphoglycerate mutase family	-	-	-	ko:K15640	-	-	-	-	ko00000	-	-	-	His_Phos_1
REGS3_k127_3338921_5	1205910.B005_0980	1.758e-39	153.0	COG1451@1|root,COG1451@2|Bacteria,2GMP6@201174|Actinobacteria,4EJ0C@85012|Streptosporangiales	201174|Actinobacteria	S	Protein of unknown function DUF45	-	-	-	ko:K07043	-	-	-	-	ko00000	-	-	-	DUF45
REGS3_k127_3338921_8	765420.OSCT_2347	3.901e-14	87.0	COG2373@1|root,COG4932@1|root,COG2373@2|Bacteria,COG4932@2|Bacteria,2GABV@200795|Chloroflexi,3752H@32061|Chloroflexia	32061|Chloroflexia	M	Cna B domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,SdrD_B
REGS3_k127_3338921_4	1313172.YM304_37930	2.043e-43	169.0	COG0652@1|root,COG0652@2|Bacteria,2GN8G@201174|Actinobacteria,4CN2J@84992|Acidimicrobiia	84992|Acidimicrobiia	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	-	-	5.2.1.8	ko:K01802,ko:K03768	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Pro_isomerase
REGS3_k127_3338921_6	1229780.BN381_100131	4.205e-34	139.0	COG4242@1|root,COG4242@2|Bacteria	2|Bacteria	PQ	Belongs to the peptidase S51 family	cphB	-	3.4.15.6	ko:K13282	-	-	R09722	RC00064,RC00141	ko00000,ko01000,ko01002	-	-	-	Peptidase_S51
REGS3_k127_3338921_1	1313172.YM304_37950	1.146e-72	255.0	COG2365@1|root,COG2365@2|Bacteria,2GK28@201174|Actinobacteria,4CNVE@84992|Acidimicrobiia	84992|Acidimicrobiia	T	Tyrosine phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Y_phosphatase3
REGS3_k127_3338921_0	1313172.YM304_38120	3.016e-122	402.0	COG1250@1|root,COG1250@2|Bacteria,2GJBM@201174|Actinobacteria,4CNMA@84992|Acidimicrobiia	84992|Acidimicrobiia	I	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
REGS3_k127_3343348_1	1121382.JQKG01000005_gene3283	1.438e-132	428.0	COG0166@1|root,COG0166@2|Bacteria,1WIGN@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	Belongs to the GPI family	pgi	-	5.3.1.9	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI
REGS3_k127_3343348_2	1229780.BN381_290057	5.687e-129	421.0	COG2141@1|root,COG2141@2|Bacteria,2H0K9@201174|Actinobacteria,3UXH6@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
REGS3_k127_3343348_15	1249627.D779_1469	3.539e-05	56.0	COG0038@1|root,COG0038@2|Bacteria,1MV4K@1224|Proteobacteria,1RQJW@1236|Gammaproteobacteria,1X0K4@135613|Chromatiales	135613|Chromatiales	P	Voltage gated chloride channel	-	-	-	-	-	-	-	-	-	-	-	-	Voltage_CLC
REGS3_k127_3343348_3	1313172.YM304_30630	5.076e-119	402.0	COG3540@1|root,COG3540@2|Bacteria,2GJCI@201174|Actinobacteria	201174|Actinobacteria	P	alkaline phosphatase	phoD	-	3.1.3.1	ko:K01077,ko:K01113	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	M00126	R02135,R04620	RC00017	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147	-	-	-	PhoD,PhoD_N
REGS3_k127_3343348_9	1313172.YM304_30600	8.789e-57	201.0	COG2185@1|root,COG2185@2|Bacteria,2IFJD@201174|Actinobacteria,4CN3T@84992|Acidimicrobiia	201174|Actinobacteria	I	B12 binding domain	icmB	-	5.4.99.2	ko:K01849	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding
REGS3_k127_3343348_4	1313172.YM304_14840	1.84e-95	322.0	COG2378@1|root,COG2378@2|Bacteria,2HGFE@201174|Actinobacteria,4CND2@84992|Acidimicrobiia	84992|Acidimicrobiia	K	WYL domain	-	-	-	-	-	-	-	-	-	-	-	-	WYL
REGS3_k127_3343348_5	1313172.YM304_14850	4.502e-91	311.0	COG2378@1|root,COG2378@2|Bacteria,2GMAU@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	pafC	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	ko:K13573	-	-	-	-	ko00000,ko03051	-	-	-	WYL
REGS3_k127_3343348_8	1313172.YM304_14860	3.299e-57	205.0	COG0847@1|root,COG0847@2|Bacteria	2|Bacteria	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease	-	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
REGS3_k127_3343348_12	1313172.YM304_31160	1.856e-26	112.0	COG4308@1|root,COG4308@2|Bacteria,2IP4X@201174|Actinobacteria	201174|Actinobacteria	Q	Limonene-12-epoxide hydrolase	-	-	3.3.2.8	ko:K10533	ko00903,map00903	-	R05784,R09387	RC01473,RC02519	ko00000,ko00001,ko01000	-	-	-	LEH
REGS3_k127_3343348_0	1313172.YM304_14880	7.681e-198	629.0	COG1875@1|root,COG1875@2|Bacteria,2GK8U@201174|Actinobacteria	201174|Actinobacteria	T	ATPase related to phosphate starvation-inducible protein PhoH	phoH2	-	-	ko:K07175	-	-	-	-	ko00000	-	-	-	PIN_4,PhoH
REGS3_k127_3343348_10	1033802.SSPSH_001819	4.799e-33	136.0	COG0346@1|root,COG4923@1|root,COG0346@2|Bacteria,COG4923@2|Bacteria,1MY1R@1224|Proteobacteria,1SQHQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Protein of unknown function (DUF429)	-	-	-	-	-	-	-	-	-	-	-	-	DUF429
REGS3_k127_3343348_7	1172180.KB911802_gene5233	7.271e-63	225.0	COG1670@1|root,COG1670@2|Bacteria,2IQW2@201174|Actinobacteria	201174|Actinobacteria	J	PFAM GCN5-related N-acetyltransferase	-	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006104,GO:0006139,GO:0006163,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0019693,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0043603,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
REGS3_k127_3343348_11	1313172.YM304_14910	6.604e-30	121.0	COG0776@1|root,COG0776@2|Bacteria,2IKQR@201174|Actinobacteria	201174|Actinobacteria	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions	hup	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009889,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2001141	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
REGS3_k127_3343348_13	1194972.MVAC_11847	4.1e-09	61.0	COG1357@1|root,COG1357@2|Bacteria	2|Bacteria	S	protein homooligomerization	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2,Pentapeptide
REGS3_k127_3343348_6	44056.XP_009040665.1	3.82e-73	256.0	COG5285@1|root,2S7ZW@2759|Eukaryota	2759|Eukaryota	Q	dioxygenase activity	-	GO:0008150,GO:0008152,GO:0009058,GO:0019748,GO:0044550,GO:0071704,GO:1900558,GO:1900560,GO:1900561,GO:1900563,GO:1901576	-	-	-	-	-	-	-	-	-	-	PhyH
REGS3_k127_3343348_14	1313172.YM304_14930	1.01e-07	54.0	COG2120@1|root,COG2120@2|Bacteria,2IR6Y@201174|Actinobacteria,4CN50@84992|Acidimicrobiia	84992|Acidimicrobiia	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
REGS3_k127_3352938_4	1200792.AKYF01000023_gene939	1.462e-13	71.0	COG5516@1|root,COG5516@2|Bacteria,1VBTD@1239|Firmicutes,4HZYY@91061|Bacilli,26XJQ@186822|Paenibacillaceae	91061|Bacilli	S	CGNR zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	ABATE,zf-CGNR
REGS3_k127_3352938_2	1068978.AMETH_5078	1.047e-22	108.0	COG0697@1|root,COG0697@2|Bacteria,2H9P8@201174|Actinobacteria,4E6ZV@85010|Pseudonocardiales	201174|Actinobacteria	EG	spore germination	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_3352938_5	419947.MRA_2003	4.511e-11	70.0	COG5654@1|root,COG5654@2|Bacteria,2IHX0@201174|Actinobacteria,239DT@1762|Mycobacteriaceae	201174|Actinobacteria	S	RES	-	-	-	-	-	-	-	-	-	-	-	-	RES
REGS3_k127_3352938_3	419947.MRA_2004	2.147e-15	80.0	2AF64@1|root,3154Z@2|Bacteria,2IKGJ@201174|Actinobacteria,239B3@1762|Mycobacteriaceae	201174|Actinobacteria	K	Protein of unknown function (DUF2384)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2384
REGS3_k127_3352938_1	35754.JNYJ01000046_gene3082	8.785e-119	411.0	COG1835@1|root,COG1835@2|Bacteria,2GKI5@201174|Actinobacteria,4DANU@85008|Micromonosporales	201174|Actinobacteria	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
REGS3_k127_3352938_6	1283299.AUKG01000001_gene2226	3.812e-07	62.0	2AVY9@1|root,31MSE@2|Bacteria,2HQF2@201174|Actinobacteria,4CRZU@84995|Rubrobacteria	84995|Rubrobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_3352938_0	216594.MMAR_0576	2.191e-170	543.0	COG0657@1|root,COG2072@1|root,COG0657@2|Bacteria,COG2072@2|Bacteria,2GKYU@201174|Actinobacteria,233MC@1762|Mycobacteriaceae	201174|Actinobacteria	P	Flavoprotein involved in K transport	pamO	-	1.14.13.92	ko:K18229	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_3,FMO-like,Pyr_redox_2,Pyr_redox_3
REGS3_k127_3360193_2	685727.REQ_18420	8.474e-52	198.0	COG2304@1|root,COG4965@1|root,COG2304@2|Bacteria,COG4965@2|Bacteria,2H577@201174|Actinobacteria	201174|Actinobacteria	U	Type ii secretion system	-	-	-	ko:K12510	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF,VWA_2
REGS3_k127_3360193_1	1151119.KB895490_gene2184	2.339e-52	196.0	COG2064@1|root,COG2064@2|Bacteria,2GK7B@201174|Actinobacteria,1WBWS@1268|Micrococcaceae	201174|Actinobacteria	NU	Type II secretion system (T2SS), protein F	-	-	-	ko:K12511	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
REGS3_k127_3360193_0	748280.NH8B_3874	2.827e-101	359.0	COG4564@1|root,COG5001@1|root,COG4564@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,2KQJ6@206351|Neisseriales	206351|Neisseriales	T	signal transduction protein containing a membrane domain, an EAL and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_9,dCache_2
REGS3_k127_34073_3	7370.XP_005178010.1	1.54e-32	130.0	KOG1954@1|root,KOG1954@2759|Eukaryota,38XK5@33154|Opisthokonta,3BBJ3@33208|Metazoa,3CVUG@33213|Bilateria,41VU7@6656|Arthropoda,3SJ40@50557|Insecta,450XZ@7147|Diptera	33208|Metazoa	TU	GTPase activity	SRL	GO:0002115,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005788,GO:0006810,GO:0006811,GO:0006812,GO:0006816,GO:0008150,GO:0012505,GO:0014823,GO:0014850,GO:0014873,GO:0014874,GO:0016528,GO:0016529,GO:0030001,GO:0031974,GO:0033018,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043502,GO:0044057,GO:0044422,GO:0044424,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0048583,GO:0050789,GO:0050896,GO:0051179,GO:0051234,GO:0051239,GO:0065007,GO:0070013,GO:0070838,GO:0072511,GO:0090257	-	-	-	-	-	-	-	-	-	-	Dynamin_N,EHD_N
REGS3_k127_34073_0	1206741.BAFX01000196_gene3610	2.539e-122	404.0	COG0477@1|root,COG2814@2|Bacteria,2I5AX@201174|Actinobacteria,4FX6Y@85025|Nocardiaceae	201174|Actinobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
REGS3_k127_34073_2	680198.SCAB_59801	4.604e-37	149.0	COG1268@1|root,COG1268@2|Bacteria,2GJ53@201174|Actinobacteria	201174|Actinobacteria	S	BioY protein	bioY	-	-	ko:K03523	ko02010,map02010	M00581,M00582	-	-	ko00000,ko00001,ko00002,ko02000	2.A.88.1,2.A.88.2	-	-	BioY
REGS3_k127_34073_1	1229780.BN381_20131	3.058e-63	239.0	COG0747@1|root,COG0747@2|Bacteria,2GJ4B@201174|Actinobacteria,3UXHK@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	E	Evidence 5 No homology to any previously reported sequences	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
REGS3_k127_341653_14	1313172.YM304_20460	7.858e-86	288.0	COG0458@1|root,COG0458@2|Bacteria,2GK5N@201174|Actinobacteria,4CMUA@84992|Acidimicrobiia	84992|Acidimicrobiia	EF	Carbamoyl-phosphate synthetase large chain, oligomerisation domain	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
REGS3_k127_341653_11	1313172.YM304_20470	3.639e-119	396.0	COG0167@1|root,COG0167@2|Bacteria,2GKC6@201174|Actinobacteria,4CN0R@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Catalyzes the conversion of dihydroorotate to orotate	pyrD	-	1.3.1.14	ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
REGS3_k127_341653_29	1313172.YM304_20480	7.477e-39	147.0	COG0099@1|root,COG0099@2|Bacteria,2IKPU@201174|Actinobacteria,4CN68@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Helix-hairpin-helix DNA-binding motif class 1	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_341653_16	1313172.YM304_20490	1.766e-75	259.0	COG0194@1|root,COG0194@2|Bacteria,2GK2M@201174|Actinobacteria,4CN5V@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Guanylate kinase homologues.	gmk	-	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
REGS3_k127_341653_31	1313172.YM304_20500	1.731e-26	111.0	COG1758@1|root,COG1758@2|Bacteria,2HG9P@201174|Actinobacteria,4CN82@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits	rpoZ	-	2.7.7.6	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
REGS3_k127_341653_5	1313172.YM304_20510	1.248e-160	517.0	COG0452@1|root,COG0452@2|Bacteria,2GJGJ@201174|Actinobacteria,4CMYE@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
REGS3_k127_341653_3	570268.ANBB01000002_gene334	5.81e-167	534.0	COG0192@1|root,COG0192@2|Bacteria,2GJ4U@201174|Actinobacteria,4EG6T@85012|Streptosporangiales	201174|Actinobacteria	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	GO:0003674,GO:0003824,GO:0004478,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0016740,GO:0016765,GO:0019899,GO:0030312,GO:0035375,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
REGS3_k127_341653_2	1313172.YM304_20530	1.099e-187	606.0	COG1198@1|root,COG1198@2|Bacteria,2HG9D@201174|Actinobacteria,4CN7P@84992|Acidimicrobiia	84992|Acidimicrobiia	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	-	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	-
REGS3_k127_341653_18	1120936.KB907217_gene3497	4.478e-70	243.0	COG2813@1|root,COG2813@2|Bacteria,2IFG7@201174|Actinobacteria,4EFU8@85012|Streptosporangiales	201174|Actinobacteria	J	Putative methyltransferase	rsmC	-	2.1.1.172	ko:K00564	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	MTS
REGS3_k127_341653_19	1313172.YM304_20560	6.249e-70	240.0	COG0242@1|root,COG0242@2|Bacteria,2GJ87@201174|Actinobacteria,4CN7F@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
REGS3_k127_341653_15	1313172.YM304_20570	1.714e-84	292.0	COG0223@1|root,COG0223@2|Bacteria,2GKH5@201174|Actinobacteria,4CN6M@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Formyl transferase, C-terminal domain	fmt	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
REGS3_k127_341653_8	1313172.YM304_20580	9.743e-133	441.0	COG0144@1|root,COG0781@1|root,COG0144@2|Bacteria,COG0781@2|Bacteria,2GM21@201174|Actinobacteria	201174|Actinobacteria	JK	Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family	fmu	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009383,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0030312,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,NusB
REGS3_k127_341653_22	1313172.YM304_20590	4.72e-65	228.0	COG0521@1|root,COG0521@2|Bacteria,2II28@201174|Actinobacteria,4CN1Q@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Probable molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	MoCF_biosynth
REGS3_k127_341653_10	1313172.YM304_20600	2.69e-131	424.0	COG0040@1|root,COG0040@2|Bacteria,2GNAX@201174|Actinobacteria,4CMTS@84992|Acidimicrobiia	84992|Acidimicrobiia	F	ATP phosphoribosyltransferase	hisG	-	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG,HisG_C
REGS3_k127_341653_33	1313172.YM304_20620	2.782e-19	96.0	COG3695@1|root,COG3695@2|Bacteria	2|Bacteria	L	enzyme binding	ybaZ	GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0005488,GO:0005515,GO:0019899,GO:0097159,GO:1901363	2.1.1.63	ko:K00567,ko:K07443	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1
REGS3_k127_341653_30	1313172.YM304_20630	9.99e-34	133.0	2FH85@1|root,3492H@2|Bacteria,2H8HQ@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_341653_20	1313172.YM304_20650	3.163e-68	239.0	COG0290@1|root,COG0290@2|Bacteria,2GJGT@201174|Actinobacteria,4CMZR@84992|Acidimicrobiia	84992|Acidimicrobiia	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	-	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
REGS3_k127_341653_32	1313172.YM304_20660	6.123e-25	110.0	COG0291@1|root,COG0291@2|Bacteria	2|Bacteria	J	Belongs to the bacterial ribosomal protein bL35 family	rpmI	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02916	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35p
REGS3_k127_341653_28	1313172.YM304_20670	1.276e-45	168.0	COG0292@1|root,COG0292@2|Bacteria,2IHTN@201174|Actinobacteria,4CN4X@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	-	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
REGS3_k127_341653_23	1313172.YM304_20680	3.227e-62	223.0	COG0566@1|root,COG0566@2|Bacteria,2HGTD@201174|Actinobacteria,4CNZQ@84992|Acidimicrobiia	84992|Acidimicrobiia	J	SpoU rRNA Methylase family	-	-	-	ko:K03437	-	-	-	-	ko00000,ko03016	-	-	-	SpoU_methylase
REGS3_k127_341653_7	1313172.YM304_20710	1.098e-141	457.0	COG0016@1|root,COG0016@2|Bacteria,2GJGG@201174|Actinobacteria,4CMPG@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
REGS3_k127_341653_0	1313172.YM304_20720	4.166e-314	987.0	COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,2GMFD@201174|Actinobacteria,4CMUN@84992|Acidimicrobiia	84992|Acidimicrobiia	J	B3/4 domain	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
REGS3_k127_341653_27	1313172.YM304_20770	4.31e-46	174.0	COG1678@1|root,COG1678@2|Bacteria,2GNRA@201174|Actinobacteria	201174|Actinobacteria	K	Belongs to the UPF0301 (AlgH) family	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K07735	-	-	-	-	ko00000,ko03000	-	-	-	DUF179
REGS3_k127_341653_6	1313172.YM304_20790	1.473e-147	474.0	COG0002@1|root,COG0002@2|Bacteria,2GKQK@201174|Actinobacteria,4CMY2@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	-	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
REGS3_k127_341653_9	1313172.YM304_20800	1.866e-132	438.0	COG0548@1|root,COG0548@2|Bacteria,2GKDS@201174|Actinobacteria,4CMYC@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	-	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
REGS3_k127_341653_4	1313172.YM304_20810	4.815e-163	522.0	COG4992@1|root,COG4992@2|Bacteria,2GKE9@201174|Actinobacteria,4CMTH@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Aminotransferase class-III	argD	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
REGS3_k127_341653_12	1313172.YM304_20820	5.154e-110	363.0	COG0078@1|root,COG0078@2|Bacteria,2GJ6H@201174|Actinobacteria,4CN2V@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain	argF	-	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
REGS3_k127_341653_24	1313172.YM304_20830	1.056e-60	214.0	COG1438@1|root,COG1438@2|Bacteria,2GKA5@201174|Actinobacteria,4CN15@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Regulates arginine biosynthesis genes	argR	-	-	ko:K03402	-	-	-	-	ko00000,ko03000	-	-	-	Arg_repressor,Arg_repressor_C
REGS3_k127_341653_1	1313172.YM304_20840	3.405e-193	613.0	COG0165@1|root,COG0165@2|Bacteria,2GJ2A@201174|Actinobacteria,4CMW7@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Argininosuccinate lyase C-terminal	argH	-	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
REGS3_k127_341653_25	35754.JNYJ01000028_gene6057	4.566e-57	209.0	COG2095@1|root,COG2095@2|Bacteria,2GMCM@201174|Actinobacteria,4DA0Z@85008|Micromonosporales	201174|Actinobacteria	U	UPF0056 membrane protein	marC	-	-	ko:K05595	-	-	-	-	ko00000,ko02000	2.A.95.1	-	-	MarC
REGS3_k127_341653_34	1394178.AWOO02000094_gene8053	5.066e-19	91.0	COG0824@1|root,COG0824@2|Bacteria	2|Bacteria	IQ	Thioesterase	ysmA	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2,Acetyltransf_10
REGS3_k127_341653_26	1385515.N791_07615	3.456e-47	176.0	COG2094@1|root,COG2094@2|Bacteria,1RE0A@1224|Proteobacteria,1S9CM@1236|Gammaproteobacteria,1X6BU@135614|Xanthomonadales	135614|Xanthomonadales	L	Belongs to the DNA glycosylase MPG family	-	GO:0003674,GO:0003824,GO:0003905,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360	3.2.2.21	ko:K03652	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Pur_DNA_glyco
REGS3_k127_341653_21	1217720.ALOX01000087_gene3033	5.466e-68	244.0	COG4427@1|root,COG4427@2|Bacteria,1R4EV@1224|Proteobacteria,2TRVP@28211|Alphaproteobacteria,2JWMB@204441|Rhodospirillales	204441|Rhodospirillales	S	Uncharacterized protein conserved in bacteria (DUF2332)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2332
REGS3_k127_341653_17	1110697.NCAST_32_10970	1.112e-74	259.0	COG2141@1|root,COG2141@2|Bacteria,2HGTQ@201174|Actinobacteria,4G1YB@85025|Nocardiaceae	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
REGS3_k127_341653_13	452637.Oter_2683	2.418e-100	336.0	COG0162@1|root,COG0162@2|Bacteria,46UVG@74201|Verrucomicrobia,3K7IA@414999|Opitutae	414999|Opitutae	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
REGS3_k127_3439261_10	706439.HMPREF9057_01988	5.343e-66	228.0	COG2077@1|root,COG2077@2|Bacteria,2II20@201174|Actinobacteria,4D4FP@85005|Actinomycetales	201174|Actinobacteria	O	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides	tpx	GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009405,GO:0009605,GO:0009607,GO:0009636,GO:0009987,GO:0015036,GO:0016209,GO:0016491,GO:0016667,GO:0016684,GO:0019725,GO:0020012,GO:0030312,GO:0030682,GO:0042221,GO:0042592,GO:0043207,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0050789,GO:0050794,GO:0050896,GO:0051409,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0051920,GO:0052060,GO:0052173,GO:0052200,GO:0052376,GO:0052551,GO:0052564,GO:0052565,GO:0052572,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0071944,GO:0075136,GO:0097237,GO:0098754,GO:0098869,GO:1990748	1.11.1.15	ko:K11065	-	-	-	-	ko00000,ko01000	-	-	-	Redoxin
REGS3_k127_3439261_1	479432.Sros_1806	1.009e-191	609.0	COG1819@1|root,COG1819@2|Bacteria,2GJN7@201174|Actinobacteria,4EHG3@85012|Streptosporangiales	201174|Actinobacteria	CG	UDP-glucoronosyl and UDP-glucosyl transferase	-	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008194,GO:0008610,GO:0009058,GO:0009247,GO:0009605,GO:0009607,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0020012,GO:0030682,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044464,GO:0046467,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0071704,GO:0071944,GO:0075136,GO:1901135,GO:1901137,GO:1901576,GO:1903509	-	-	-	-	-	-	-	-	-	-	Glyco_tran_28_C,UDPGT
REGS3_k127_3439261_2	1283299.AUKG01000001_gene3269	1.477e-172	556.0	COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria	201174|Actinobacteria	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.8	ko:K00130	ko00260,ko01100,map00260,map01100	M00555	R02565,R02566	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
REGS3_k127_3439261_13	235985.BBPN01000035_gene745	1.4e-49	194.0	COG3281@1|root,COG3281@2|Bacteria,2IBUS@201174|Actinobacteria	201174|Actinobacteria	G	Aminoglycoside phosphotransferase	-	-	2.7.1.175	ko:K16146	ko00500,ko01100,map00500,map01100	-	R09945	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	-
REGS3_k127_3439261_8	2002.JOEQ01000004_gene2635	4.759e-93	315.0	COG2222@1|root,COG2222@2|Bacteria,2IBP7@201174|Actinobacteria,4EIEZ@85012|Streptosporangiales	201174|Actinobacteria	M	sugar isomerase	-	-	-	-	-	-	-	-	-	-	-	-	SIS
REGS3_k127_3439261_17	1313172.YM304_07910	2.342e-44	184.0	COG3291@1|root,COG3291@2|Bacteria,2I7X8@201174|Actinobacteria,4CP5K@84992|Acidimicrobiia	2|Bacteria	S	Pkd domain containing protein	-	-	3.1.3.5,3.2.1.14	ko:K01081,ko:K01183,ko:K20276	ko00230,ko00240,ko00520,ko00760,ko01100,ko01110,ko02024,map00230,map00240,map00520,map00760,map01100,map01110,map02024	-	R00183,R00511,R00963,R01126,R01206,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02334,R02719,R03346	RC00017,RC00467	ko00000,ko00001,ko01000	-	GH18	-	F5_F8_type_C,Melibiase_2,NPCBM_assoc,PKD,PPC,Trypsin_2,VPEP
REGS3_k127_3439261_7	1313172.YM304_16090	2.2e-94	318.0	COG0289@1|root,COG0289@2|Bacteria,2GM2T@201174|Actinobacteria,4CN2G@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate	dapB	-	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_C,DapB_N
REGS3_k127_3439261_6	351607.Acel_1507	5.231e-100	340.0	COG0612@1|root,COG0612@2|Bacteria,2GJZ3@201174|Actinobacteria,4ERHK@85013|Frankiales	201174|Actinobacteria	S	Belongs to the peptidase M16 family	pepR	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
REGS3_k127_3439261_0	1313172.YM304_16080	0.0	1130.0	COG1185@1|root,COG1185@2|Bacteria,2GIT2@201174|Actinobacteria,4CMSF@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	-	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,S1
REGS3_k127_3439261_14	1313172.YM304_01020	1.39e-47	176.0	COG4803@1|root,COG4803@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF1269
REGS3_k127_3439261_19	1321778.HMPREF1982_02076	6.824e-34	132.0	COG0184@1|root,COG0184@2|Bacteria,1VA5C@1239|Firmicutes,24MRM@186801|Clostridia	186801|Clostridia	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	-	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
REGS3_k127_3439261_24	467661.RKLH11_259	2.29e-09	68.0	COG1605@1|root,COG1605@2|Bacteria,1NEMH@1224|Proteobacteria,2UGZQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	chorismate mutase	pchB	-	4.2.99.21	ko:K04782	ko01053,ko01110,ko01130,map01053,map01110,map01130	-	R06602	RC01549,RC02148	ko00000,ko00001,ko01000	-	-	-	CM_2
REGS3_k127_3439261_9	1229780.BN381_310018	9.591e-80	282.0	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	-	-	3.4.11.5	ko:K01259,ko:K19311	ko00330,map00330	-	R00135	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Abhydrolase_1,Hydrolase_4
REGS3_k127_3439261_4	36809.MAB_0507	4.285e-129	429.0	COG1020@1|root,COG1020@2|Bacteria,2GKGU@201174|Actinobacteria,23579@1762|Mycobacteriaceae	201174|Actinobacteria	I	Belongs to the long-chain O-acyltransferase family	-	GO:0000302,GO:0001666,GO:0003674,GO:0003824,GO:0004144,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006629,GO:0006638,GO:0006639,GO:0006641,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008374,GO:0008610,GO:0009058,GO:0009628,GO:0009987,GO:0010035,GO:0016020,GO:0016411,GO:0016740,GO:0016746,GO:0016747,GO:0019432,GO:0030312,GO:0036293,GO:0040007,GO:0042221,GO:0042493,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044403,GO:0044419,GO:0044464,GO:0045017,GO:0046460,GO:0046463,GO:0046486,GO:0047196,GO:0050896,GO:0051704,GO:0070482,GO:0071704,GO:0071731,GO:0071944,GO:0097366,GO:1901576,GO:1901698,GO:1901700	-	-	-	-	-	-	-	-	-	-	DUF1298,WES_acyltransf
REGS3_k127_3439261_5	247634.GPB2148_643	3.476e-102	349.0	COG0657@1|root,COG0657@2|Bacteria,1R4AU@1224|Proteobacteria,1RQMN@1236|Gammaproteobacteria,1J5AK@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	I	COG0657 Esterase lipase	aes	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3,Peptidase_S9
REGS3_k127_3439261_23	1150599.MPHLEI_18860	1.825e-14	84.0	COG2852@1|root,COG2852@2|Bacteria,2GSDS@201174|Actinobacteria,232PY@1762|Mycobacteriaceae	201174|Actinobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF559
REGS3_k127_3439261_3	1313172.YM304_27740	1.202e-170	539.0	COG0031@1|root,COG0031@2|Bacteria,2GIXE@201174|Actinobacteria,4CMZT@84992|Acidimicrobiia	201174|Actinobacteria	E	Pyridoxal-phosphate dependent enzyme	cysM	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019344,GO:0019752,GO:0019842,GO:0030170,GO:0032991,GO:0033847,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.5.1.113	ko:K21148	ko04122,map04122	-	R10610	RC03225	ko00000,ko00001,ko01000	-	-	-	PALP
REGS3_k127_3439261_11	1122609.AUGT01000011_gene3568	1.219e-51	189.0	COG0526@1|root,COG0526@2|Bacteria,2HZTZ@201174|Actinobacteria	201174|Actinobacteria	CO	COG0526, thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
REGS3_k127_3439261_22	1205680.CAKO01000038_gene1693	3.413e-17	86.0	COG0526@1|root,COG0526@2|Bacteria,1P67Q@1224|Proteobacteria	1224|Proteobacteria	CO	COG0526, thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_3439261_18	1229780.BN381_80116	3.218e-35	138.0	COG1310@1|root,COG1310@2|Bacteria,2IFB5@201174|Actinobacteria,3UXRV@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	JAB/MPN domain	mec	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006508,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0008270,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016787,GO:0019344,GO:0019538,GO:0019752,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0046914,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	3.13.1.6	ko:K21140	ko04122,map04122	-	R11524	RC00064,RC00090	ko00000,ko00001,ko01000	-	-	-	Prok-JAB
REGS3_k127_3439261_12	1313172.YM304_27770	3.04e-50	183.0	COG0691@1|root,COG0691@2|Bacteria,2GJX1@201174|Actinobacteria,4CN4T@84992|Acidimicrobiia	84992|Acidimicrobiia	J	the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA	smpB	-	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
REGS3_k127_3439261_20	285514.JNWO01000010_gene9614	2.204e-27	121.0	COG3758@1|root,COG3758@2|Bacteria,2IFWP@201174|Actinobacteria	201174|Actinobacteria	S	HutD	ves	-	-	ko:K09975	-	-	-	-	ko00000	-	-	-	HutD
REGS3_k127_3439261_15	929712.KI912613_gene3837	1.164e-45	169.0	COG0346@1|root,COG0346@2|Bacteria,2GQ3H@201174|Actinobacteria,4CT6T@84995|Rubrobacteria	84995|Rubrobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
REGS3_k127_3451077_5	1169143.KB911035_gene1984	2.885e-85	287.0	COG3618@1|root,COG3618@2|Bacteria,1N2QM@1224|Proteobacteria,2VIDM@28216|Betaproteobacteria,1K42J@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Amidohydrolase	-	-	3.1.1.57	ko:K10221	ko00362,ko00627,ko01120,map00362,map00627,map01120	-	R04277	RC03110	ko00000,ko00001,ko01000	-	-	-	Amidohydro_2
REGS3_k127_3451077_1	298655.KI912266_gene4993	1.997e-208	656.0	COG0683@1|root,COG0683@2|Bacteria,2IAAV@201174|Actinobacteria	201174|Actinobacteria	E	Periplasmic binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
REGS3_k127_3451077_6	269800.Tfu_0275	6.54e-69	246.0	COG1028@1|root,COG1028@2|Bacteria,2GNUM@201174|Actinobacteria,4EHXA@85012|Streptosporangiales	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
REGS3_k127_3451077_2	298655.KI912266_gene3866	3.305e-139	455.0	COG2159@1|root,COG2159@2|Bacteria,2HG7W@201174|Actinobacteria,4EX8Y@85013|Frankiales	201174|Actinobacteria	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
REGS3_k127_3451077_3	298655.KI912266_gene3868	1.275e-125	412.0	COG4638@1|root,COG4638@2|Bacteria	2|Bacteria	P	Rieske (2fe-2S)	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
REGS3_k127_3451077_4	298655.KI912266_gene3865	3.227e-102	341.0	COG4221@1|root,COG4221@2|Bacteria,2HA4H@201174|Actinobacteria	201174|Actinobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
REGS3_k127_3451077_0	298655.KI912266_gene4642	1.013e-221	691.0	COG2159@1|root,COG2159@2|Bacteria,2GKG2@201174|Actinobacteria,4EUWU@85013|Frankiales	201174|Actinobacteria	S	PFAM Amidohydrolase 2	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
REGS3_k127_3459355_3	1313172.YM304_42640	5.83e-46	168.0	COG0360@1|root,COG0360@2|Bacteria,2IQHD@201174|Actinobacteria,4CNDH@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Binds together with S18 to 16S ribosomal RNA	rpsF	-	-	ko:K02990	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S6
REGS3_k127_3459355_2	1313172.YM304_42630	2.909e-53	196.0	COG0629@1|root,COG0629@2|Bacteria,2GMM3@201174|Actinobacteria,4CN4R@84992|Acidimicrobiia	84992|Acidimicrobiia	L	Single-strand binding protein family	ssb	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
REGS3_k127_3459355_6	1313172.YM304_42620	6.562e-34	134.0	COG0238@1|root,COG0238@2|Bacteria,2IQ92@201174|Actinobacteria,4CN8W@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit	rpsR	-	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
REGS3_k127_3459355_4	1313172.YM304_42610	6.323e-41	155.0	COG0359@1|root,COG0359@2|Bacteria,2IKX7@201174|Actinobacteria,4CNBU@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Binds to the 23S rRNA	rplI	-	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
REGS3_k127_3459355_0	1313172.YM304_42600	5.722e-190	603.0	COG0305@1|root,COG0305@2|Bacteria,2GKXQ@201174|Actinobacteria,4CMT1@84992|Acidimicrobiia	84992|Acidimicrobiia	L	Participates in initiation and elongation during chromosome replication	dnaB	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
REGS3_k127_3459355_5	234621.RER_08600	4.671e-40	151.0	COG3450@1|root,COG3450@2|Bacteria,2HT6E@201174|Actinobacteria,4G55Y@85025|Nocardiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF861)	-	-	-	ko:K06995	-	-	-	-	ko00000	-	-	-	Cupin_3
REGS3_k127_3459355_1	1032480.MLP_41980	1.306e-89	307.0	COG3214@1|root,COG3214@2|Bacteria,2GK0T@201174|Actinobacteria,4DMYQ@85009|Propionibacteriales	201174|Actinobacteria	S	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_42
REGS3_k127_3520607_14	1313172.YM304_24570	6.701e-100	339.0	COG3191@1|root,COG3191@2|Bacteria,2GJKQ@201174|Actinobacteria	201174|Actinobacteria	EQ	peptidase S58, DmpA	dmpA	-	-	ko:K18572	ko00332,ko01130,map00332,map01130	-	R10752	RC00090,RC00096	ko00000,ko00001,ko01000	-	-	-	Peptidase_S58
REGS3_k127_3520607_16	338966.Ppro_3536	1.192e-85	292.0	COG0413@1|root,COG0413@2|Bacteria,1MU3B@1224|Proteobacteria,42MES@68525|delta/epsilon subdivisions,2WIQK@28221|Deltaproteobacteria,43S2A@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
REGS3_k127_3520607_17	1313172.YM304_24560	5.075e-82	282.0	COG0414@1|root,COG0414@2|Bacteria,2GJEQ@201174|Actinobacteria,4CNWM@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate	panC	-	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_ligase
REGS3_k127_3520607_24	35754.JNYJ01000014_gene4862	2.772e-45	186.0	COG1835@1|root,COG2755@1|root,COG1835@2|Bacteria,COG2755@2|Bacteria,2GKI5@201174|Actinobacteria,4D9CD@85008|Micromonosporales	201174|Actinobacteria	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
REGS3_k127_3520607_20	1313172.YM304_24550	2.329e-67	238.0	COG1266@1|root,COG1266@2|Bacteria	2|Bacteria	V	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
REGS3_k127_3520607_30	1380370.JIBA01000002_gene2607	0.0004205	51.0	COG1714@1|root,COG1714@2|Bacteria,2HXE4@201174|Actinobacteria,4FGCN@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF2510)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2510,RDD
REGS3_k127_3520607_6	1123320.KB889675_gene4065	3.634e-162	522.0	COG0665@1|root,COG0665@2|Bacteria,2GJQ9@201174|Actinobacteria	201174|Actinobacteria	E	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
REGS3_k127_3520607_18	1380391.JIAS01000018_gene887	2.748e-73	258.0	COG4638@1|root,COG4638@2|Bacteria,1MWXW@1224|Proteobacteria,2U071@28211|Alphaproteobacteria,2JZMF@204441|Rhodospirillales	204441|Rhodospirillales	P	Ring hydroxylating alpha subunit (catalytic domain)	-	-	-	-	-	-	-	-	-	-	-	-	Rieske,Ring_hydroxyl_A
REGS3_k127_3520607_12	1313172.YM304_24520	1.506e-119	402.0	COG0308@1|root,COG0308@2|Bacteria,2GJWF@201174|Actinobacteria	201174|Actinobacteria	E	Peptidase M1, membrane alanine aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1
REGS3_k127_3520607_5	1207075.PputUW4_03017	1.602e-165	550.0	COG0014@1|root,COG0014@2|Bacteria,1MUGJ@1224|Proteobacteria,1RMAY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate	-	-	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
REGS3_k127_3520607_13	1313172.YM304_24490	1.381e-103	342.0	COG0491@1|root,COG0491@2|Bacteria,2GNS6@201174|Actinobacteria	201174|Actinobacteria	P	PFAM Metallo-beta-lactamase superfamily	gloB	GO:0003674,GO:0003824,GO:0004416,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006082,GO:0006090,GO:0006518,GO:0006575,GO:0006749,GO:0006750,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016787,GO:0016788,GO:0016790,GO:0019184,GO:0019752,GO:0031974,GO:0032787,GO:0034641,GO:0042398,GO:0043043,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0051186,GO:0051188,GO:0070013,GO:0071704,GO:1901564,GO:1901566,GO:1901576	-	-	-	-	-	-	-	-	-	-	Lactamase_B
REGS3_k127_3520607_22	1380356.JNIK01000021_gene4421	1.409e-52	191.0	COG4430@1|root,COG4430@2|Bacteria,2IN25@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF1905)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1905,OmdA
REGS3_k127_3520607_4	298654.FraEuI1c_5749	1.105e-177	574.0	28JDP@1|root,2Z97Z@2|Bacteria,2I9EC@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_3520607_29	1382359.JIAL01000001_gene153	4.063e-10	69.0	COG3501@1|root,COG3501@2|Bacteria,3Y52V@57723|Acidobacteria,2JJEC@204432|Acidobacteriia	204432|Acidobacteriia	S	Rhs element vgr protein	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_3520607_28	926566.Terro_2151	4.039e-13	78.0	COG3501@1|root,COG3501@2|Bacteria,3Y52V@57723|Acidobacteria,2JJEC@204432|Acidobacteriia	204432|Acidobacteriia	S	Rhs element vgr protein	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_3520607_27	1380370.JIBA01000017_gene2964	2.703e-22	104.0	COG3714@1|root,COG3714@2|Bacteria,2IG79@201174|Actinobacteria,4FGG0@85021|Intrasporangiaceae	201174|Actinobacteria	S	YhhN family	-	-	-	-	-	-	-	-	-	-	-	-	YhhN
REGS3_k127_3520607_26	1121272.KB903251_gene606	9.133e-24	111.0	COG0730@1|root,COG0730@2|Bacteria,2GPQV@201174|Actinobacteria	201174|Actinobacteria	S	Sulfite exporter TauE/SafE	-	-	-	-	-	-	-	-	-	-	-	-	TauE
REGS3_k127_3520607_23	1238186.AOCN01000011_gene1380	6.195e-46	169.0	COG1522@1|root,COG1522@2|Bacteria,2GP1P@201174|Actinobacteria,4FNCP@85023|Microbacteriaceae	201174|Actinobacteria	K	helix_turn_helix ASNC type	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
REGS3_k127_3520607_1	1298863.AUEP01000004_gene2180	1.26e-206	650.0	COG0001@1|root,COG0001@2|Bacteria,2HBVS@201174|Actinobacteria,4DU4P@85009|Propionibacteriales	201174|Actinobacteria	H	Aminotransferase class-III	-	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
REGS3_k127_3520607_11	1206733.BAGC01000038_gene93	1.371e-119	396.0	COG2175@1|root,COG2175@2|Bacteria,2GNUC@201174|Actinobacteria,4FY58@85025|Nocardiaceae	201174|Actinobacteria	Q	Taurine catabolism dioxygenase TauD, TfdA family	tauD	-	1.14.11.17	ko:K03119,ko:K22303	ko00430,ko00920,map00430,map00920	-	R05320	RC01331	ko00000,ko00001,ko01000	-	-	-	TauD
REGS3_k127_3520607_7	1068980.ARVW01000001_gene1331	2.459e-144	464.0	COG3285@1|root,COG3285@2|Bacteria,2GM0A@201174|Actinobacteria,4DY4T@85010|Pseudonocardiales	201174|Actinobacteria	L	DNA primase, small subunit	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_3520607_25	1121933.AUHH01000007_gene3298	3.68e-43	169.0	COG0697@1|root,COG0697@2|Bacteria,2H9P8@201174|Actinobacteria,4DRK8@85009|Propionibacteriales	201174|Actinobacteria	EG	spore germination	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_3520607_15	1321778.HMPREF1982_00173	3.759e-90	313.0	COG0477@1|root,COG2814@2|Bacteria,1TS6K@1239|Firmicutes,24AKU@186801|Clostridia	186801|Clostridia	EGP	Major Facilitator	-	-	-	ko:K08153	-	M00717	-	-	ko00000,ko00002,ko02000	2.A.1.2.8	-	-	MFS_1,Sugar_tr
REGS3_k127_3520607_2	1313172.YM304_06940	1.522e-196	619.0	COG1960@1|root,COG1960@2|Bacteria,2GKVN@201174|Actinobacteria,4CNFE@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Acyl-CoA dehydrogenase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
REGS3_k127_3520607_8	1448389.BAVQ01000009_gene3826	1.886e-127	415.0	COG0451@1|root,COG0451@2|Bacteria,2I9DG@201174|Actinobacteria	201174|Actinobacteria	GM	Epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
REGS3_k127_3520607_19	1123320.KB889675_gene3982	1.044e-68	242.0	COG1028@1|root,COG1028@2|Bacteria,2GP5U@201174|Actinobacteria	201174|Actinobacteria	IQ	Dehydrogenases with different specificities (Related to short-chain alcohol dehydrogenases)	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
REGS3_k127_3520607_0	1313172.YM304_38870	1.763e-216	706.0	COG1033@1|root,COG1033@2|Bacteria,2I731@201174|Actinobacteria	201174|Actinobacteria	S	MMPL family	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
REGS3_k127_3520607_10	1449065.JMLL01000011_gene2417	2.548e-121	398.0	COG0646@1|root,COG0646@2|Bacteria,1NPFY@1224|Proteobacteria,2UJRS@28211|Alphaproteobacteria,43GPP@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Catalyzes the formation of methionine from L-homocysteine and S-adenosyl-L-methionine	yitJ	-	2.1.1.13,2.1.1.5	ko:K00544,ko:K00548	ko00260,ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00260,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R02821,R09365	RC00035,RC00113,RC00496,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	S-methyl_trans
REGS3_k127_3520607_3	1123320.KB889669_gene3279	1.967e-195	616.0	COG2141@1|root,COG2141@2|Bacteria,2GP93@201174|Actinobacteria	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
REGS3_k127_3520607_9	105420.BBPO01000025_gene7171	6.895e-123	407.0	COG3173@1|root,COG3173@2|Bacteria,2GSTN@201174|Actinobacteria,2NG71@228398|Streptacidiphilus	201174|Actinobacteria	S	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
REGS3_k127_3520607_21	1449347.JQLN01000007_gene1630	9.596e-61	226.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	GT87,PMT_2
REGS3_k127_3523093_1	869210.Marky_2033	1.571e-103	360.0	COG1404@1|root,COG1404@2|Bacteria,1WIDU@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	O	peptidase S8 and S53, subtilisin, kexin, sedolisin	-	-	3.4.21.111	ko:K20754	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Inhibitor_I9,Peptidase_S8
REGS3_k127_3523093_0	1313172.YM304_04880	6.755e-109	361.0	COG1929@1|root,COG1929@2|Bacteria,2GKHX@201174|Actinobacteria,4CN9A@84992|Acidimicrobiia	84992|Acidimicrobiia	G	Glycerate kinase family	-	-	2.7.1.165	ko:K00865	ko00260,ko00561,ko00630,ko01100,ko01120,ko01130,map00260,map00561,map00630,map01100,map01120,map01130	-	R08572	RC00002,RC00428	ko00000,ko00001,ko01000	-	-	-	Gly_kinase
REGS3_k127_3540226_3	649831.L083_4820	1.333e-12	80.0	COG5001@1|root,COG5001@2|Bacteria,2GIZF@201174|Actinobacteria	201174|Actinobacteria	T	signal transduction protein containing a membrane domain an EAL and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_4
REGS3_k127_3540226_0	1229780.BN381_100149	7.551e-168	539.0	COG0617@1|root,COG0617@2|Bacteria,2GMT1@201174|Actinobacteria,3UW9X@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	J	Probable RNA and SrmB- binding site of polymerase A	pcnA	-	2.7.7.19,2.7.7.72	ko:K00970,ko:K00974	ko03013,ko03018,map03013,map03018	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd
REGS3_k127_3540226_1	1121877.JQKF01000017_gene200	1.243e-97	329.0	COG0123@1|root,COG0123@2|Bacteria,2GJUH@201174|Actinobacteria,4CMXH@84992|Acidimicrobiia	84992|Acidimicrobiia	BQ	Histone deacetylase domain	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
REGS3_k127_3540226_4	1382306.JNIM01000001_gene2526	5.286e-12	76.0	COG0454@1|root,COG0456@2|Bacteria,2G7CX@200795|Chloroflexi	200795|Chloroflexi	K	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
REGS3_k127_3540226_2	1313172.YM304_42730	2.781e-39	166.0	2B0G0@1|root,31STG@2|Bacteria,2HGDS@201174|Actinobacteria,4CNCA@84992|Acidimicrobiia	84992|Acidimicrobiia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_3571628_5	1463855.JOHV01000033_gene1330	1.536e-15	85.0	COG1309@1|root,COG1309@2|Bacteria,2GMPD@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	ko:K22107	-	-	-	-	ko00000,ko03000	-	-	-	TetR_N
REGS3_k127_3571628_2	1206725.BAFU01000052_gene1538	9.666e-98	327.0	COG1024@1|root,COG1024@2|Bacteria,2IF91@201174|Actinobacteria,4G8SX@85025|Nocardiaceae	201174|Actinobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
REGS3_k127_3571628_6	1122611.KB903940_gene1815	2.537e-11	73.0	COG1309@1|root,COG1309@2|Bacteria,2GUIR@201174|Actinobacteria,4EM84@85012|Streptosporangiales	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
REGS3_k127_3571628_4	1343740.M271_47065	2.178e-32	136.0	2FJHE@1|root,34B6Z@2|Bacteria,2IHA3@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_4
REGS3_k127_3571628_1	1242864.D187_001451	7.941e-112	372.0	28MAM@1|root,2ZAP9@2|Bacteria,1R58T@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_3571628_0	1123320.KB889669_gene3279	9.397e-184	582.0	COG2141@1|root,COG2141@2|Bacteria,2GP93@201174|Actinobacteria	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
REGS3_k127_3604379_0	298655.KI912266_gene3025	8.017e-142	458.0	COG2141@1|root,COG2141@2|Bacteria,2GKP1@201174|Actinobacteria,4EV45@85013|Frankiales	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
REGS3_k127_3604379_3	1123320.KB889662_gene1675	4.548e-67	238.0	COG1414@1|root,COG1414@2|Bacteria,2IQ0V@201174|Actinobacteria	201174|Actinobacteria	K	helix_turn_helix isocitrate lyase regulation	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR
REGS3_k127_3604379_5	327277.JHAL01000002_gene119	1.671e-19	92.0	COG1917@1|root,COG1917@2|Bacteria,2IHSV@201174|Actinobacteria,4D0ZF@85004|Bifidobacteriales	201174|Actinobacteria	S	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
REGS3_k127_3604379_2	35754.JNYJ01000033_gene2665	2.777e-82	279.0	COG2227@1|root,COG2227@2|Bacteria,2I2JZ@201174|Actinobacteria,4DCM7@85008|Micromonosporales	201174|Actinobacteria	H	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
REGS3_k127_3604379_1	1121952.ATXT01000013_gene2136	2.42e-127	423.0	COG1914@1|root,COG1914@2|Bacteria,2GJSM@201174|Actinobacteria,4FNCM@85023|Microbacteriaceae	201174|Actinobacteria	P	Natural resistance-associated macrophage protein	-	-	-	-	-	-	-	-	-	-	-	-	Nramp
REGS3_k127_3604379_4	1304865.JAGF01000001_gene494	9.764e-43	163.0	arCOG06733@1|root,313GU@2|Bacteria,2ICAF@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_3604379_6	754436.JCM19237_5712	1.598e-05	56.0	2AXQS@1|root,31PRM@2|Bacteria,1QMEQ@1224|Proteobacteria,1TJPP@1236|Gammaproteobacteria,1Y1HI@135623|Vibrionales	135623|Vibrionales	S	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_3631650_9	1097668.BYI23_B001680	9.747e-12	68.0	COG1024@1|root,COG1024@2|Bacteria,1PK10@1224|Proteobacteria,2WF2X@28216|Betaproteobacteria	28216|Betaproteobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
REGS3_k127_3631650_4	351607.Acel_0232	8.936e-72	258.0	COG3511@1|root,COG3511@2|Bacteria,2II4P@201174|Actinobacteria,4ET75@85013|Frankiales	201174|Actinobacteria	M	Phosphoesterase family	-	-	3.1.3.64	ko:K21302	ko00562,ko01100,ko05152,map00562,map01100,map05152	-	-	-	ko00000,ko00001,ko01000	-	-	-	Phosphoesterase
REGS3_k127_3631650_7	1313172.YM304_38150	7.592e-41	153.0	COG2127@1|root,COG2127@2|Bacteria,2IQ3Z@201174|Actinobacteria,4CN8E@84992|Acidimicrobiia	84992|Acidimicrobiia	S	ATP-dependent Clp protease adaptor protein ClpS	clpS	-	-	ko:K06891	-	-	-	-	ko00000	-	-	-	ClpS
REGS3_k127_3631650_3	1313172.YM304_38720	5.094e-133	430.0	COG0109@1|root,COG0109@2|Bacteria,2GJMY@201174|Actinobacteria,4CMQ7@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	ctaB	-	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
REGS3_k127_3631650_1	1313172.YM304_38710	6.481e-151	495.0	COG0843@1|root,COG0843@2|Bacteria,2GJHX@201174|Actinobacteria,4CMUD@84992|Acidimicrobiia	2|Bacteria	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	-	-	1.10.3.10	ko:K02298	ko00190,ko01100,map00190,map01100	M00417	R11335	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.5	-	-	COX1
REGS3_k127_3631650_5	1313172.YM304_38700	1.225e-55	201.0	COG1845@1|root,COG1845@2|Bacteria,2HDD0@201174|Actinobacteria	201174|Actinobacteria	C	Cytochrome c oxidase subunit III	-	-	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
REGS3_k127_3631650_6	1313172.YM304_38690	5.959e-53	201.0	2FBCP@1|root,343IH@2|Bacteria,2H8EE@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_3631650_0	1313172.YM304_38680	1.485e-158	514.0	COG1622@1|root,COG1622@2|Bacteria,2GNXA@201174|Actinobacteria,4CN92@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM
REGS3_k127_3631650_2	1313172.YM304_38670	1.718e-148	474.0	COG0843@1|root,COG0843@2|Bacteria,2GJHX@201174|Actinobacteria,4CMUD@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
REGS3_k127_3641803_5	28042.GU90_06820	1.442e-05	55.0	2E5E7@1|root,33065@2|Bacteria,2IN6X@201174|Actinobacteria,4E5FP@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_3641803_3	1048339.KB913029_gene3211	3.155e-151	484.0	COG2141@1|root,COG2141@2|Bacteria,2GJ6T@201174|Actinobacteria,4ESG7@85013|Frankiales	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
REGS3_k127_3641803_0	1313172.YM304_24080	6.763e-248	778.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4CNF1@84992|Acidimicrobiia	201174|Actinobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
REGS3_k127_3641803_1	118161.KB235922_gene1210	5.612e-223	702.0	COG2072@1|root,COG2072@2|Bacteria,1G8W3@1117|Cyanobacteria	1117|Cyanobacteria	C	Flavin-binding monooxygenase-like	-	-	-	-	-	-	-	-	-	-	-	-	FMO-like
REGS3_k127_3641803_2	1282876.BAOK01000002_gene536	5.269e-187	593.0	COG1960@1|root,COG1960@2|Bacteria,1MU2V@1224|Proteobacteria,2TSK3@28211|Alphaproteobacteria,4BPRD@82117|unclassified Alphaproteobacteria	2|Bacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
REGS3_k127_3641803_4	1313172.YM304_24030	7.301e-22	96.0	COG0500@1|root,COG2226@2|Bacteria,2GKFZ@201174|Actinobacteria,4CN6D@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)	menG	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
REGS3_k127_364797_4	1150599.MPHLEI_09739	7.52e-87	292.0	COG1028@1|root,COG1028@2|Bacteria,2HFC2@201174|Actinobacteria,23CP0@1762|Mycobacteriaceae	201174|Actinobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_364797_0	1002340.AFCF01000066_gene394	3.193e-166	536.0	COG0112@1|root,COG0112@2|Bacteria,1MWDM@1224|Proteobacteria,2TS5T@28211|Alphaproteobacteria,34EJX@302485|Phaeobacter	28211|Alphaproteobacteria	E	Serine hydroxymethyltransferase	glyA_3	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
REGS3_k127_364797_7	1122182.KB903814_gene3080	7.353e-45	167.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase,Glyoxalase_2
REGS3_k127_364797_1	397278.JOJN01000003_gene2112	1.333e-153	496.0	COG0798@1|root,COG0798@2|Bacteria,2GJ4H@201174|Actinobacteria,4DP3B@85009|Propionibacteriales	201174|Actinobacteria	P	Sodium Bile acid symporter family	arsB	-	1.20.4.1	ko:K03325,ko:K03741	-	-	-	-	ko00000,ko01000,ko02000	2.A.59	-	-	SBF
REGS3_k127_364797_2	1449069.JMLO01000001_gene2005	3.616e-111	368.0	COG2175@1|root,COG2175@2|Bacteria,2I9TE@201174|Actinobacteria,4G38T@85025|Nocardiaceae	201174|Actinobacteria	Q	Taurine catabolism dioxygenase TauD, TfdA family	-	-	-	-	-	-	-	-	-	-	-	-	TauD
REGS3_k127_364797_6	1380347.JNII01000005_gene3882	1.659e-45	169.0	COG0346@1|root,COG0346@2|Bacteria,2IFUM@201174|Actinobacteria,4EVK6@85013|Frankiales	201174|Actinobacteria	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	cadI	GO:0008150,GO:0010035,GO:0010038,GO:0042221,GO:0046686,GO:0050896	-	-	-	-	-	-	-	-	-	-	Glyoxalase
REGS3_k127_364797_8	1380393.JHVP01000003_gene833	2.506e-27	112.0	COG0640@1|root,COG0640@2|Bacteria,2IQDH@201174|Actinobacteria,4EWGW@85013|Frankiales	201174|Actinobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
REGS3_k127_364797_3	1463853.JOHW01000010_gene1317	9.914e-91	304.0	COG0500@1|root,COG2226@2|Bacteria,2HEKM@201174|Actinobacteria	201174|Actinobacteria	Q	Methyltransferase type 11	-	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_31
REGS3_k127_364797_5	1313172.YM304_03240	2.567e-63	228.0	COG1793@1|root,COG1793@2|Bacteria,2IKE5@201174|Actinobacteria	201174|Actinobacteria	L	dna ligase	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
REGS3_k127_3657339_1	1313172.YM304_10030	6.811e-119	388.0	COG0657@1|root,COG0657@2|Bacteria,2GKX2@201174|Actinobacteria,4CNXU@84992|Acidimicrobiia	84992|Acidimicrobiia	I	alpha/beta hydrolase fold	-	-	-	ko:K01066	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_3
REGS3_k127_3657339_4	1313172.YM304_10010	7.853e-94	321.0	COG1573@1|root,COG1573@2|Bacteria,2GK1I@201174|Actinobacteria,4CNUH@84992|Acidimicrobiia	84992|Acidimicrobiia	L	Uracil DNA glycosylase superfamily	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
REGS3_k127_3657339_2	1313172.YM304_10000	1.822e-97	322.0	COG0406@1|root,COG0406@2|Bacteria,2GK8N@201174|Actinobacteria,4CNCR@84992|Acidimicrobiia	84992|Acidimicrobiia	G	Histidine phosphatase superfamily (branch 1)	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
REGS3_k127_3657339_7	1313172.YM304_09990	1.635e-56	207.0	298YA@1|root,2ZW25@2|Bacteria,2GIYI@201174|Actinobacteria,4CN9I@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Protein of unknown function (DUF3090)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3090
REGS3_k127_3657339_3	1313172.YM304_09980	2.076e-96	320.0	COG5032@1|root,COG5032@2|Bacteria,2GME7@201174|Actinobacteria,4CN1N@84992|Acidimicrobiia	84992|Acidimicrobiia	BDLTU	Phosphatidylinositol	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_3657339_0	1313172.YM304_09930	7.199e-125	409.0	28TMF@1|root,2ZFV1@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_3657339_5	1313172.YM304_03220	1.09e-75	278.0	COG4447@1|root,COG4447@2|Bacteria,2I7X7@201174|Actinobacteria,4CNBK@84992|Acidimicrobiia	2|Bacteria	S	PFAM FecR protein	-	-	-	ko:K07279	-	-	-	-	ko00000,ko02000,ko02044	1.B.12	-	-	CBM_2,CBM_4_9,CelD_N,Cu-binding_MopE,Glyco_hydro_9,Peptidase_M66,SLH
REGS3_k127_3657339_6	1313172.YM304_16100	2.977e-57	223.0	COG3858@1|root,COG3858@2|Bacteria,2HZ7I@201174|Actinobacteria	201174|Actinobacteria	S	Glycosyl hydrolases family 18	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_18
REGS3_k127_3670359_3	1313172.YM304_13900	3.234e-101	336.0	COG2141@1|root,COG2141@2|Bacteria,2GMRE@201174|Actinobacteria	201174|Actinobacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
REGS3_k127_3670359_5	47839.CCAU010000004_gene1147	7.775e-86	295.0	COG2141@1|root,COG2141@2|Bacteria,2HQDR@201174|Actinobacteria,2379B@1762|Mycobacteriaceae	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
REGS3_k127_3670359_4	1313172.YM304_13910	9.842e-96	321.0	COG1024@1|root,COG1024@2|Bacteria,2I9MR@201174|Actinobacteria	201174|Actinobacteria	I	Enoyl-CoA hydratase	echA8_1	-	-	-	-	-	-	-	-	-	-	-	ECH_1
REGS3_k127_3670359_1	1313172.YM304_13930	2.485e-281	871.0	COG1838@1|root,COG1951@1|root,COG1838@2|Bacteria,COG1951@2|Bacteria,2GK6D@201174|Actinobacteria	201174|Actinobacteria	C	Catalyzes the reversible hydration of fumarate to (S)- malate	fumB	-	4.2.1.2,4.2.1.32	ko:K01676,ko:K01678,ko:K03780	ko00020,ko00620,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00630,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00339,R01082	RC00443,RC01382	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase,Fumerase_C
REGS3_k127_3670359_8	1449068.JMLQ01000002_gene3055	1.282e-42	174.0	COG0730@1|root,COG0730@2|Bacteria,2IIY7@201174|Actinobacteria,4FZZ6@85025|Nocardiaceae	201174|Actinobacteria	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
REGS3_k127_3670359_0	1313172.YM304_13960	1.252e-301	949.0	COG1643@1|root,COG1643@2|Bacteria,2GMAW@201174|Actinobacteria	201174|Actinobacteria	L	ATP-dependent helicase HrpB	hrpB	-	3.6.4.13	ko:K03579	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HA2,Helicase_C,HrpB_C
REGS3_k127_3670359_7	1313172.YM304_13970	3.496e-56	201.0	2FJ53@1|root,34AVA@2|Bacteria,2H8CM@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_3670359_6	1313172.YM304_13980	3.067e-58	214.0	COG1184@1|root,COG1184@2|Bacteria,2H70W@201174|Actinobacteria	201174|Actinobacteria	J	Initiation factor 2 subunit family	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_3670359_9	1298863.AUEP01000012_gene3795	1.026e-41	158.0	COG0748@1|root,COG0748@2|Bacteria,2I3IN@201174|Actinobacteria,4DX11@85009|Propionibacteriales	201174|Actinobacteria	P	Pfam:Pyridox_oxidase	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Putative_PNPOx
REGS3_k127_3670359_2	326424.FRAAL1414	1.361e-151	491.0	COG1167@1|root,COG1167@2|Bacteria,2GM6I@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2,GntR
REGS3_k127_3707419_56	1313172.YM304_00750	0.0002091	50.0	COG1403@1|root,COG1403@2|Bacteria,2GVP9@201174|Actinobacteria	201174|Actinobacteria	V	Domain of unknown function (DUF222)	-	-	-	-	-	-	-	-	-	-	-	-	DUF222
REGS3_k127_3707419_36	1048339.KB913029_gene1045	9.311e-79	276.0	COG2141@1|root,COG2141@2|Bacteria,2GKP1@201174|Actinobacteria,4EV45@85013|Frankiales	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
REGS3_k127_3707419_19	1210045.ALNP01000010_gene1189	8.224e-124	406.0	COG2171@1|root,COG2171@2|Bacteria,2GIZ9@201174|Actinobacteria	201174|Actinobacteria	E	Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA	dapD	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0008666,GO:0016020,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016748,GO:0016749,GO:0030312,GO:0031402,GO:0031420,GO:0040007,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0048037,GO:0050662,GO:0071944	2.3.1.117	ko:K00674	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R04365	RC00004,RC01136	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1201c	Hexapep_2,THDPS_M
REGS3_k127_3707419_6	1313172.YM304_28830	1.767e-240	757.0	COG1190@1|root,COG1190@2|Bacteria,2GKE0@201174|Actinobacteria,4CMX2@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
REGS3_k127_3707419_29	1313172.YM304_28820	5.678e-93	321.0	COG0741@1|root,COG0741@2|Bacteria,2IF18@201174|Actinobacteria	201174|Actinobacteria	M	D-alanyl-D-alanine carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M15_4
REGS3_k127_3707419_7	1313172.YM304_28810	2.863e-216	683.0	COG1249@1|root,COG1249@2|Bacteria,2GIXY@201174|Actinobacteria,4CMT7@84992|Acidimicrobiia	201174|Actinobacteria	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
REGS3_k127_3707419_53	1306990.BARG01000014_gene1299	9.798e-13	74.0	COG1714@1|root,COG1714@2|Bacteria,2HGSH@201174|Actinobacteria	201174|Actinobacteria	S	RDD domain containing protein	pra	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	RDD
REGS3_k127_3707419_2	1313172.YM304_28760	8.145e-280	869.0	COG0439@1|root,COG4770@1|root,COG0439@2|Bacteria,COG4770@2|Bacteria,2GIZP@201174|Actinobacteria,4CMS3@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Biotin carboxylase C-terminal domain	-	-	6.3.4.14,6.4.1.2,6.4.1.3	ko:K11263	ko00061,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00741	R00742,R01859,R04385	RC00040,RC00097,RC00253,RC00367,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
REGS3_k127_3707419_42	1313172.YM304_28750	2.932e-56	205.0	COG0340@1|root,COG0340@2|Bacteria,2GN8Q@201174|Actinobacteria,4CND8@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Biotin/lipoate A/B protein ligase family	-	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB
REGS3_k127_3707419_30	1313172.YM304_28740	6.506e-89	304.0	COG1316@1|root,COG1316@2|Bacteria,2GJJJ@201174|Actinobacteria,4CP53@84992|Acidimicrobiia	201174|Actinobacteria	K	Cell envelope-related transcriptional attenuator domain	-	-	-	-	-	-	-	-	-	-	-	-	LytR_C,LytR_cpsA_psr
REGS3_k127_3707419_15	1229780.BN381_10111	1.483e-145	473.0	COG1209@1|root,COG1209@2|Bacteria,2GP20@201174|Actinobacteria,3UWQW@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	M	Nucleotidyl transferase	-	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
REGS3_k127_3707419_37	1229780.BN381_10112	3.918e-76	260.0	COG1898@1|root,COG1898@2|Bacteria	2|Bacteria	M	dTDP-4-dehydrorhamnose 3,5-epimerase activity	rfbC	-	1.1.1.133,4.2.1.46,5.1.3.13	ko:K00067,ko:K01710,ko:K01790	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R02777,R06513,R06514	RC00182,RC00402,RC01531	ko00000,ko00001,ko00002,ko01000	-	-	-	dTDP_sugar_isom
REGS3_k127_3707419_18	1229780.BN381_10113	4.392e-130	423.0	COG1088@1|root,COG1088@2|Bacteria,2GNDU@201174|Actinobacteria,3UWG6@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	M	Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily	strE	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0008460,GO:0009058,GO:0009059,GO:0009987,GO:0016051,GO:0016829,GO:0016835,GO:0016836,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0045226,GO:0046379,GO:0071704,GO:1901576	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
REGS3_k127_3707419_34	1313172.YM304_28700	1.228e-80	281.0	COG1091@1|root,COG1091@2|Bacteria,2GNY8@201174|Actinobacteria,4CN33@84992|Acidimicrobiia	84992|Acidimicrobiia	M	Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose	-	-	1.1.1.133	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000	-	-	-	RmlD_sub_bind
REGS3_k127_3707419_32	1313172.YM304_03860	3.49e-85	290.0	COG2833@1|root,COG2833@2|Bacteria	2|Bacteria	I	Protein of unknown function (DUF455)	-	-	2.7.1.165	ko:K11529	ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200	M00346	R08572	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF455
REGS3_k127_3707419_24	1229780.BN381_10178	3.367e-114	377.0	COG0451@1|root,COG0451@2|Bacteria,2GP0W@201174|Actinobacteria,3UX7T@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	GM	RmlD substrate binding domain	fcl	-	1.1.1.271	ko:K02377	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R05692	RC01014	ko00000,ko00001,ko01000	-	-	-	Epimerase
REGS3_k127_3707419_22	1313172.YM304_28670	1.091e-114	379.0	COG0438@1|root,COG0438@2|Bacteria,2GMEW@201174|Actinobacteria,4CNQH@84992|Acidimicrobiia	84992|Acidimicrobiia	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
REGS3_k127_3707419_17	1313172.YM304_28660	4.639e-131	428.0	COG0438@1|root,COG0438@2|Bacteria,2IJX1@201174|Actinobacteria	201174|Actinobacteria	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
REGS3_k127_3707419_13	1313172.YM304_28650	6.289e-149	487.0	COG0438@1|root,COG0438@2|Bacteria,2GMI6@201174|Actinobacteria	201174|Actinobacteria	M	glycosyl transferase group 1	-	-	-	ko:K00786	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glycos_transf_1
REGS3_k127_3707419_48	1313172.YM304_28640	1.063e-37	153.0	2968S@1|root,2ZTIT@2|Bacteria,2HEBZ@201174|Actinobacteria,4CNCH@84992|Acidimicrobiia	84992|Acidimicrobiia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_3707419_21	1313172.YM304_28630	8.067e-119	394.0	COG1208@1|root,COG1208@2|Bacteria,2GKTE@201174|Actinobacteria,4CMYG@84992|Acidimicrobiia	84992|Acidimicrobiia	JM	Nucleotidyl transferase	-	-	2.7.7.13	ko:K00966	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
REGS3_k127_3707419_28	1313172.YM304_28620	1.886e-98	331.0	COG0451@1|root,COG0451@2|Bacteria,2I2UT@201174|Actinobacteria,4CN6I@84992|Acidimicrobiia	84992|Acidimicrobiia	GM	GDP-mannose 4,6 dehydratase	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
REGS3_k127_3707419_26	1313172.YM304_28610	3.13e-113	376.0	COG0391@1|root,COG0391@2|Bacteria,2GJZ2@201174|Actinobacteria,4CN0F@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Uncharacterised protein family UPF0052	-	-	2.7.8.28	ko:K11212	ko00680,ko01120,map00680,map01120	M00378	R09398	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	UPF0052
REGS3_k127_3707419_31	1313172.YM304_28600	9.898e-88	304.0	COG0438@1|root,COG0438@2|Bacteria,2GIVP@201174|Actinobacteria,4CN35@84992|Acidimicrobiia	84992|Acidimicrobiia	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
REGS3_k127_3707419_9	1313172.YM304_28590	1.297e-179	566.0	COG1089@1|root,COG1089@2|Bacteria,2GNMA@201174|Actinobacteria,4CMT5@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose	gmd	-	4.2.1.47	ko:K01711	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R00888	RC00402	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
REGS3_k127_3707419_14	1313172.YM304_28580	2.054e-148	482.0	COG2244@1|root,COG2244@2|Bacteria	2|Bacteria	S	polysaccharide biosynthetic process	-	GO:0003674,GO:0005488,GO:0005575,GO:0005576,GO:0008150,GO:0009987,GO:0044764,GO:0046812,GO:0051704	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	Polysacc_synt,Polysacc_synt_3
REGS3_k127_3707419_38	1313172.YM304_29760	4.037e-72	273.0	COG2385@1|root,COG2755@1|root,COG3409@1|root,COG2385@2|Bacteria,COG2755@2|Bacteria,COG3409@2|Bacteria	2|Bacteria	M	Peptidoglycan-binding domain 1 protein	-	-	3.4.17.14	ko:K07260,ko:K21449	ko00550,ko01100,ko01502,ko02020,map00550,map01100,map01502,map02020	M00651	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504,ko02000	1.B.40.2	-	-	Amidase_3,CHAP,ChW,PG_binding_1,SpoIID,VanY
REGS3_k127_3707419_3	1313172.YM304_28560	1.265e-272	876.0	COG1216@1|root,COG1216@2|Bacteria,2GIUN@201174|Actinobacteria,4CN7G@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3
REGS3_k127_3707419_46	1313172.YM304_28540	4.783e-43	162.0	COG0526@1|root,COG0526@2|Bacteria,2H7FG@201174|Actinobacteria	201174|Actinobacteria	CO	COG0526, thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_3707419_1	1313172.YM304_28530	5.494e-302	937.0	COG0465@1|root,COG0465@2|Bacteria,2GJ4Q@201174|Actinobacteria,4CMRD@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
REGS3_k127_3707419_44	1313172.YM304_28510	5.194e-51	190.0	COG1266@1|root,COG1266@2|Bacteria,2H0BD@201174|Actinobacteria,4CNBE@84992|Acidimicrobiia	84992|Acidimicrobiia	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
REGS3_k127_3707419_5	1313172.YM304_28500	1.064e-251	805.0	COG5617@1|root,COG5617@2|Bacteria,2H32H@201174|Actinobacteria	201174|Actinobacteria	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_3707419_8	1313172.YM304_28490	2.648e-214	682.0	COG1109@1|root,COG1109@2|Bacteria,2GJQA@201174|Actinobacteria,4CMU2@84992|Acidimicrobiia	84992|Acidimicrobiia	G	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III	-	-	5.4.2.8	ko:K01840	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01818	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
REGS3_k127_3707419_50	1229780.BN381_10201	4.253e-26	109.0	COG2835@1|root,COG2835@2|Bacteria	2|Bacteria	EG	tetraacyldisaccharide 4'-kinase activity	-	-	-	ko:K09791	-	-	-	-	ko00000	-	-	-	Trm112p
REGS3_k127_3707419_33	1313172.YM304_28470	3.652e-83	294.0	COG4102@1|root,COG4102@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	ASH,PQQ_3
REGS3_k127_3707419_4	1313172.YM304_28430	7.56e-256	799.0	COG0499@1|root,COG0499@2|Bacteria,2GK2Q@201174|Actinobacteria,4CMTB@84992|Acidimicrobiia	84992|Acidimicrobiia	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
REGS3_k127_3707419_41	1313172.YM304_28390	9.665e-64	226.0	COG2364@1|root,COG2364@2|Bacteria,2GKA1@201174|Actinobacteria,4CNY7@84992|Acidimicrobiia	84992|Acidimicrobiia	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_3707419_40	1282876.BAOK01000001_gene1307	1.718e-64	228.0	COG0596@1|root,COG0596@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on ester bonds	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
REGS3_k127_3707419_45	1313172.YM304_28380	1.848e-46	179.0	COG1040@1|root,COG1040@2|Bacteria	2|Bacteria	K	competence protein	comF	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Pribosyltran
REGS3_k127_3707419_49	101510.RHA1_ro02725	7.805e-29	124.0	COG1011@1|root,COG1011@2|Bacteria,2I8XE@201174|Actinobacteria,4FYZE@85025|Nocardiaceae	201174|Actinobacteria	S	hydrolase	-	-	-	ko:K07025,ko:K18569	ko00332,ko01130,map00332,map01130	-	R10748	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2,Hydrolase
REGS3_k127_3707419_0	1313172.YM304_28340	0.0	1369.0	COG0653@1|root,COG0653@2|Bacteria,2GIRT@201174|Actinobacteria,4CMVS@84992|Acidimicrobiia	84992|Acidimicrobiia	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
REGS3_k127_3707419_11	1313172.YM304_28330	2.529e-167	532.0	COG1186@1|root,COG1186@2|Bacteria,2GJ0F@201174|Actinobacteria,4CMPD@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
REGS3_k127_3707419_20	1313172.YM304_28320	4.639e-122	394.0	COG2884@1|root,COG2884@2|Bacteria,2GJE1@201174|Actinobacteria,4CMPM@84992|Acidimicrobiia	84992|Acidimicrobiia	D	ATPases associated with a variety of cellular activities	ftsE	-	-	ko:K09812	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	ABC_tran
REGS3_k127_3707419_35	1313172.YM304_28310	3.929e-79	275.0	COG2177@1|root,COG2177@2|Bacteria,2GJMA@201174|Actinobacteria,4CN4Q@84992|Acidimicrobiia	84992|Acidimicrobiia	D	Part of the ABC transporter FtsEX involved in cellular division	ftsX	-	-	ko:K09811	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	-
REGS3_k127_3707419_16	1313172.YM304_28300	1.587e-133	431.0	COG1024@1|root,COG1024@2|Bacteria,2HEIS@201174|Actinobacteria	201174|Actinobacteria	I	Enoyl-CoA hydratase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
REGS3_k127_3707419_10	1333998.M2A_1395	3.38e-179	576.0	COG0318@1|root,COG0318@2|Bacteria,1MUIC@1224|Proteobacteria,2U3CV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
REGS3_k127_3707419_43	1313172.YM304_28270	7.586e-55	199.0	COG2346@1|root,COG2346@2|Bacteria,2IKPF@201174|Actinobacteria	201174|Actinobacteria	O	PFAM globin	glbO	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008144,GO:0008150,GO:0015669,GO:0015671,GO:0015893,GO:0016020,GO:0019825,GO:0020037,GO:0036094,GO:0042221,GO:0042493,GO:0044464,GO:0046906,GO:0048037,GO:0050896,GO:0051179,GO:0051234,GO:0071944,GO:0097159,GO:1901363	-	ko:K06886	-	-	-	-	ko00000	-	-	-	Bac_globin
REGS3_k127_3707419_39	1313172.YM304_28230	6.027e-66	235.0	COG0566@1|root,COG0566@2|Bacteria,2GJ12@201174|Actinobacteria	201174|Actinobacteria	J	rRNA methyltransferase	-	-	-	ko:K03437	-	-	-	-	ko00000,ko03016	-	-	-	SpoU_methylase
REGS3_k127_3707419_12	1120936.KB907224_gene2604	1.105e-166	527.0	COG0447@1|root,COG0447@2|Bacteria,2GK5G@201174|Actinobacteria,4EI6I@85012|Streptosporangiales	201174|Actinobacteria	H	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)	menB	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0008150,GO:0008152,GO:0008935,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016020,GO:0016043,GO:0016829,GO:0016830,GO:0016833,GO:0022607,GO:0034214,GO:0042180,GO:0042181,GO:0043933,GO:0044085,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0051186,GO:0051188,GO:0051259,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:1901576,GO:1901661,GO:1901663	4.1.3.36	ko:K01661	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R07263	RC01923	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
REGS3_k127_3707419_27	1313172.YM304_28210	2.139e-110	363.0	COG1478@1|root,COG1478@2|Bacteria,2GMJ8@201174|Actinobacteria,4CN3M@84992|Acidimicrobiia	84992|Acidimicrobiia	C	F420-0:Gamma-glutamyl ligase	fbiB	-	6.3.2.31,6.3.2.34	ko:K12234	ko00680,ko01120,map00680,map01120	M00378	R09399,R09400	RC00064,RC00090,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_ligase
REGS3_k127_3707419_25	1313172.YM304_36700	1.904e-113	374.0	COG0208@1|root,COG0208@2|Bacteria,2GKGZ@201174|Actinobacteria	201174|Actinobacteria	F	PFAM Fatty acid desaturase, type 2	desA	-	1.14.19.11,1.14.19.2,1.14.19.26	ko:K03921	ko00061,ko01040,ko01212,map00061,map01040,map01212	-	R03370,R08161,R11108,R11109	RC00917	ko00000,ko00001,ko01000,ko01004	-	-	-	FA_desaturase_2
REGS3_k127_3707419_55	1120949.KB903294_gene4198	3.399e-05	52.0	COG3794@1|root,COG3794@2|Bacteria,2HPHB@201174|Actinobacteria,4DKS7@85008|Micromonosporales	201174|Actinobacteria	C	Copper binding proteins, plastocyanin/azurin family	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind
REGS3_k127_3707419_54	138119.DSY1780	6.189e-08	64.0	COG1388@1|root,COG3409@1|root,COG1388@2|Bacteria,COG3409@2|Bacteria,1TT2K@1239|Firmicutes,24965@186801|Clostridia,261US@186807|Peptococcaceae	186801|Clostridia	M	peptidoglycan-binding domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	LysM,NLPC_P60,PG_binding_1
REGS3_k127_3707419_47	1313172.YM304_13280	3.736e-39	159.0	COG2866@1|root,COG2866@2|Bacteria	2|Bacteria	E	metallocarboxypeptidase activity	-	-	-	ko:K14054	-	-	-	-	ko00000	-	-	-	Peptidase_M14
REGS3_k127_3734789_7	640510.BC1001_4023	3.269e-07	53.0	COG4447@1|root,COG4447@2|Bacteria,1ND1J@1224|Proteobacteria,2VMA5@28216|Betaproteobacteria,1K2TY@119060|Burkholderiaceae	28216|Betaproteobacteria	S	protein related to plant photosystem II stability assembly factor	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_3734789_6	215803.DB30_7934	3.576e-23	102.0	COG1977@1|root,COG1977@2|Bacteria,1N4M4@1224|Proteobacteria,43BB7@68525|delta/epsilon subdivisions,2X6QD@28221|Deltaproteobacteria,2Z3C9@29|Myxococcales	28221|Deltaproteobacteria	H	ThiS family	-	-	-	-	-	-	-	-	-	-	-	-	ThiS
REGS3_k127_3734789_3	1313172.YM304_14110	1.668e-77	266.0	COG1011@1|root,COG1011@2|Bacteria	2|Bacteria	S	phosphatase activity	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
REGS3_k127_3734789_1	1313172.YM304_14270	2.149e-185	583.0	COG2301@1|root,COG2301@2|Bacteria,2GK5J@201174|Actinobacteria,4CNND@84992|Acidimicrobiia	84992|Acidimicrobiia	G	HpcH/HpaI aldolase/citrate lyase family	-	-	4.1.3.24,4.1.3.25,4.1.3.34	ko:K01644,ko:K08691	ko00630,ko00660,ko00680,ko00720,ko01120,ko01200,ko02020,map00630,map00660,map00680,map00720,map01120,map01200,map02020	M00346,M00373,M00376	R00237,R00362,R00473,R00934	RC00067,RC00307,RC00308,RC00311,RC00407,RC00502,RC01118,RC01205	ko00000,ko00001,ko00002,ko01000	-	-	-	HpcH_HpaI
REGS3_k127_3734789_2	1313172.YM304_14280	1.234e-124	405.0	COG2301@1|root,COG2301@2|Bacteria,2GK5J@201174|Actinobacteria,4CNND@84992|Acidimicrobiia	201174|Actinobacteria	G	HpcH/HpaI aldolase/citrate lyase family	mcl2	-	4.1.3.34	ko:K01644	ko02020,map02020	-	R00362	RC00067,RC01118	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI,PEP-utilizers_C
REGS3_k127_3734789_4	525909.Afer_1783	2.031e-76	264.0	COG0412@1|root,COG0412@2|Bacteria,2GNWB@201174|Actinobacteria,4CN01@84992|Acidimicrobiia	84992|Acidimicrobiia	Q	Dienelactone hydrolase family	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
REGS3_k127_3734789_0	543632.JOJL01000036_gene2971	2.554e-221	695.0	COG0160@1|root,COG0160@2|Bacteria,2I2F3@201174|Actinobacteria,4DAIM@85008|Micromonosporales	201174|Actinobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.55	ko:K15372	ko00410,ko00430,ko01100,map00410,map00430,map01100	-	R00908,R01684	RC00006,RC00062	ko00000,ko00001,ko01000	-	-	-	Aminotran_3
REGS3_k127_3734789_5	1121382.JQKG01000065_gene2586	1.837e-55	209.0	COG0697@1|root,COG0697@2|Bacteria	2|Bacteria	EG	spore germination	MA20_35690	-	-	-	-	-	-	-	-	-	-	-	EamA
REGS3_k127_3754351_4	666685.R2APBS1_0674	1.698e-08	66.0	2EIP2@1|root,33CEF@2|Bacteria,1QSUQ@1224|Proteobacteria,1RWF0@1236|Gammaproteobacteria,1X3GT@135614|Xanthomonadales	135614|Xanthomonadales	S	Uncharacterised nucleotidyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_5
REGS3_k127_3754351_2	340.xcc-b100_2579	7.104e-47	192.0	COG0438@1|root,COG0438@2|Bacteria,1PDQY@1224|Proteobacteria,1SE53@1236|Gammaproteobacteria,1X59A@135614|Xanthomonadales	135614|Xanthomonadales	M	Hexosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
REGS3_k127_3754351_6	1007104.SUS17_271	0.000452	51.0	COG1493@1|root,COG1493@2|Bacteria,1NNN5@1224|Proteobacteria,2UFPB@28211|Alphaproteobacteria,2K65M@204457|Sphingomonadales	204457|Sphingomonadales	T	Serine kinase of the HPr protein, regulates carbohydrate metabolism	-	-	-	-	-	-	-	-	-	-	-	-	Hpr_kinase_C
REGS3_k127_3754351_3	1449048.JQKU01000011_gene3147	1.119e-28	122.0	COG3832@1|root,COG3832@2|Bacteria,2GSCI@201174|Actinobacteria,238RP@1762|Mycobacteriaceae	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1,MDMPI_N
REGS3_k127_3754351_1	1123023.JIAI01000002_gene4804	4.432e-53	192.0	COG1720@1|root,COG1720@2|Bacteria,2IKKT@201174|Actinobacteria	201174|Actinobacteria	S	Uncharacterised protein family UPF0066	-	-	-	-	-	-	-	-	-	-	-	-	UPF0066
REGS3_k127_3754351_0	700508.D174_16210	6.877e-103	345.0	COG5470@1|root,COG5470@2|Bacteria,2GU5A@201174|Actinobacteria,23C12@1762|Mycobacteriaceae	201174|Actinobacteria	S	NIPSNAP family containing protein	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_3754351_5	1313172.YM304_39810	4.166e-05	50.0	COG1403@1|root,COG1403@2|Bacteria,2GVP9@201174|Actinobacteria	201174|Actinobacteria	V	Domain of unknown function (DUF222)	-	-	-	-	-	-	-	-	-	-	-	-	DUF222
REGS3_k127_3764865_6	468556.AQYG01000036_gene3281	4.99e-19	97.0	COG1277@1|root,COG1277@2|Bacteria,2I3PQ@201174|Actinobacteria,4GCZQ@85026|Gordoniaceae	201174|Actinobacteria	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_4
REGS3_k127_3764865_4	1229780.BN381_150083	2.632e-50	191.0	COG0412@1|root,COG0412@2|Bacteria	2|Bacteria	Q	carboxymethylenebutenolidase activity	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
REGS3_k127_3764865_1	1313172.YM304_04640	1.451e-87	304.0	COG0664@1|root,COG0664@2|Bacteria,2GMPN@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	ko:K01420,ko:K10914,ko:K21561,ko:K21564	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
REGS3_k127_3764865_3	1313172.YM304_04650	1.336e-64	228.0	COG1211@1|root,COG1211@2|Bacteria,2I767@201174|Actinobacteria	201174|Actinobacteria	I	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	ispD	-	2.7.7.60	ko:K00991	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD
REGS3_k127_3764865_2	1313172.YM304_04660	1.439e-65	230.0	COG0245@1|root,COG0245@2|Bacteria,2II8H@201174|Actinobacteria,4CN4V@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)	ispF	-	2.7.7.60,4.6.1.12	ko:K01770,ko:K12506	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633,R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD,YgbB
REGS3_k127_3764865_0	1313172.YM304_04670	3.732e-92	313.0	COG0566@1|root,COG0566@2|Bacteria,2GJMR@201174|Actinobacteria,4CN59@84992|Acidimicrobiia	84992|Acidimicrobiia	J	RNA 2'-O ribose methyltransferase substrate binding	-	-	2.1.1.185	ko:K03218	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SpoU_methylase,SpoU_sub_bind
REGS3_k127_3764865_7	1313172.YM304_17370	1.744e-12	72.0	2FIWN@1|root,34AMS@2|Bacteria,2H89S@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_3764865_5	696747.NIES39_O03890	2.478e-28	117.0	COG2197@1|root,COG2197@2|Bacteria,1G33W@1117|Cyanobacteria,1H6WN@1150|Oscillatoriales	1117|Cyanobacteria	K	PFAM Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
REGS3_k127_3866264_3	1463821.JOGR01000004_gene2378	7.088e-54	198.0	COG1272@1|root,COG1272@2|Bacteria,2GJGQ@201174|Actinobacteria,4EZPA@85014|Glycomycetales	201174|Actinobacteria	S	Haemolysin-III related	hlyIII	-	-	ko:K11068	-	-	-	-	ko00000,ko02042	-	-	-	HlyIII
REGS3_k127_3866264_1	298655.KI912266_gene6293	1.051e-129	430.0	COG0277@1|root,COG0277@2|Bacteria,2GKI9@201174|Actinobacteria,4ESN2@85013|Frankiales	201174|Actinobacteria	C	PFAM FAD linked oxidase	-	-	-	-	-	-	-	-	-	-	-	-	FAD-oxidase_C,FAD_binding_4
REGS3_k127_3866264_2	1122138.AQUZ01000002_gene1887	2.379e-93	328.0	COG2006@1|root,COG2006@2|Bacteria,2IDQI@201174|Actinobacteria,4DTTW@85009|Propionibacteriales	201174|Actinobacteria	S	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_3866264_0	1313172.YM304_18860	2.415e-159	517.0	COG2141@1|root,COG2141@2|Bacteria,2GJRF@201174|Actinobacteria	201174|Actinobacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
REGS3_k127_3866264_4	1120948.KB903217_gene1154	3.001e-34	140.0	COG0220@1|root,COG0220@2|Bacteria,2GJ8R@201174|Actinobacteria,4DY5Q@85010|Pseudonocardiales	201174|Actinobacteria	J	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA	trmB	GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008176,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0036265,GO:0040007,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0106004,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234	2.1.1.33	ko:K03439	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_4
REGS3_k127_3866264_7	1170562.Cal6303_4471	0.0008437	50.0	COG3409@1|root,COG3409@2|Bacteria,1G6VX@1117|Cyanobacteria	1117|Cyanobacteria	M	Peptidoglycan-binding domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1
REGS3_k127_3866264_5	1380354.JIAN01000005_gene2900	1.386e-15	84.0	COG0681@1|root,COG0681@2|Bacteria,2GX48@201174|Actinobacteria	201174|Actinobacteria	U	TIGRFAM peptidase S26B, signal peptidase	-	-	3.4.21.89	ko:K13280	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
REGS3_k127_3866264_6	1033730.CAHG01000016_gene461	2.236e-12	72.0	2BBSN@1|root,325AU@2|Bacteria,2HAF6@201174|Actinobacteria,4DW9U@85009|Propionibacteriales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_3882997_2	1121952.ATXT01000013_gene2110	1.318e-46	176.0	COG4291@1|root,COG4291@2|Bacteria,2IIVD@201174|Actinobacteria,4FNQT@85023|Microbacteriaceae	201174|Actinobacteria	S	Protein of unknown function (DUF1345)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1345
REGS3_k127_3882997_0	886293.Sinac_4309	2.046e-225	715.0	COG1233@1|root,COG1233@2|Bacteria	2|Bacteria	Q	all-trans-retinol 13,14-reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
REGS3_k127_3882997_3	68199.JNZO01000013_gene3966	2.43e-20	98.0	COG3427@1|root,COG3427@2|Bacteria,2I3CZ@201174|Actinobacteria	201174|Actinobacteria	E	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_3882997_1	479435.Kfla_0724	1.827e-60	223.0	28INB@1|root,2Z8NQ@2|Bacteria,2GM2K@201174|Actinobacteria,4DWZ9@85009|Propionibacteriales	201174|Actinobacteria	S	Iron-containing redox enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Haem_oxygenas_2
REGS3_k127_4052528_6	1313172.YM304_02380	2.536e-10	73.0	COG1376@1|root,COG3409@1|root,COG1376@2|Bacteria,COG3409@2|Bacteria,2GXGF@201174|Actinobacteria	201174|Actinobacteria	M	ErfK YbiS YcfS YnhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1,YkuD
REGS3_k127_4052528_4	436229.JOEH01000053_gene6376	2.107e-44	181.0	COG0726@1|root,COG0823@1|root,COG0726@2|Bacteria,COG0823@2|Bacteria,2HPUJ@201174|Actinobacteria,2NK9B@228398|Streptacidiphilus	201174|Actinobacteria	GU	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	PD40
REGS3_k127_4052528_2	1313172.YM304_38980	3.699e-64	235.0	COG0642@1|root,COG0642@2|Bacteria,2GJIV@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
REGS3_k127_4052528_1	1313172.YM304_38970	9.262e-82	278.0	COG0745@1|root,COG0745@2|Bacteria,2GKFS@201174|Actinobacteria,4CMYH@84992|Acidimicrobiia	201174|Actinobacteria	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
REGS3_k127_4052528_3	479431.Namu_5018	8.106e-64	225.0	COG2197@1|root,COG2197@2|Bacteria,2GJKM@201174|Actinobacteria,4ESNK@85013|Frankiales	201174|Actinobacteria	K	Two component transcriptional regulator, LuxR family	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
REGS3_k127_4052528_0	1380390.JIAT01000013_gene27	6.106e-87	303.0	COG4585@1|root,COG4585@2|Bacteria,2IAG1@201174|Actinobacteria,4CR3I@84995|Rubrobacteria	84995|Rubrobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
REGS3_k127_4052528_5	1313172.YM304_38960	2.48e-10	61.0	COG0141@1|root,COG0141@2|Bacteria,2GKKA@201174|Actinobacteria,4CN2M@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	-	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
REGS3_k127_4058393_3	426716.JOAJ01000001_gene1104	3.601e-68	239.0	COG2141@1|root,COG2141@2|Bacteria,2HVKH@201174|Actinobacteria,4FVX1@85025|Nocardiaceae	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
REGS3_k127_4058393_0	710686.Mycsm_02647	5.187e-94	314.0	COG0235@1|root,COG0235@2|Bacteria,2GJ8W@201174|Actinobacteria,235V2@1762|Mycobacteriaceae	201174|Actinobacteria	G	Class II aldolase	-	-	-	-	-	-	-	-	-	-	-	-	Aldolase_II
REGS3_k127_4058393_2	1173023.KE650771_gene2819	7.222e-77	266.0	COG1262@1|root,COG1262@2|Bacteria,1G4C8@1117|Cyanobacteria,1JJTS@1189|Stigonemataceae	1117|Cyanobacteria	S	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
REGS3_k127_4058393_5	68170.KL590496_gene9366	4.059e-32	133.0	COG1309@1|root,COG1309@2|Bacteria,2GJ7G@201174|Actinobacteria,4DZZT@85010|Pseudonocardiales	201174|Actinobacteria	K	regulatory protein TetR	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
REGS3_k127_4058393_4	1282876.BAOK01000001_gene3434	1.154e-34	138.0	COG1917@1|root,COG1917@2|Bacteria,1RB86@1224|Proteobacteria	1224|Proteobacteria	S	PFAM Cupin 2 conserved barrel domain protein	-	-	1.13.11.41	ko:K05913	ko00363,ko01120,map00363,map01120	-	R01305	RC00415,RC01565	ko00000,ko00001,ko01000	-	-	-	Cupin_7
REGS3_k127_4058393_6	1894.JOER01000038_gene3004	3.784e-24	109.0	COG1595@1|root,COG1595@2|Bacteria,2GN5Y@201174|Actinobacteria	201174|Actinobacteria	K	belongs to the sigma-70 factor family, ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
REGS3_k127_4058393_1	1435356.Y013_00620	7.974e-83	278.0	COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria,4FUW5@85025|Nocardiaceae	201174|Actinobacteria	I	Belongs to the thiolase family	-	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
REGS3_k127_4070619_2	1123320.KB889568_gene5420	3.526e-40	171.0	COG2197@1|root,COG3629@1|root,COG3899@1|root,COG2197@2|Bacteria,COG3629@2|Bacteria,COG3899@2|Bacteria,2I3CX@201174|Actinobacteria	201174|Actinobacteria	K	PFAM regulatory protein LuxR	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD,GerE,Trans_reg_C
REGS3_k127_4070619_1	1306174.JODP01000009_gene6628	9.258e-61	222.0	COG1122@1|root,COG1122@2|Bacteria,2GK4F@201174|Actinobacteria	201174|Actinobacteria	P	Spherulation-specific family 4	-	-	-	-	-	-	-	-	-	-	-	-	Spherulin4
REGS3_k127_4070619_0	1121377.KB906400_gene1341	1.577e-125	409.0	COG0451@1|root,COG0451@2|Bacteria	2|Bacteria	GM	ADP-glyceromanno-heptose 6-epimerase activity	-	-	4.2.1.46,5.1.3.2	ko:K01710,ko:K01784	ko00052,ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00052,map00520,map00521,map00523,map00525,map01055,map01100,map01130	M00361,M00362,M00632,M00793	R00291,R02984,R06513	RC00289,RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
REGS3_k127_4301868_5	469383.Cwoe_2182	1.29e-124	405.0	COG3665@1|root,COG3665@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF1989)	-	-	-	ko:K09967	-	-	-	-	ko00000	-	-	-	DUF1989
REGS3_k127_4301868_2	1394178.AWOO02000081_gene2192	2.256e-138	452.0	COG0665@1|root,COG0665@2|Bacteria,2GNAE@201174|Actinobacteria,4EQSY@85012|Streptosporangiales	201174|Actinobacteria	E	FAD dependent oxidoreductase	-	-	1.5.3.1	ko:K00303	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO
REGS3_k127_4301868_10	1306174.JODP01000013_gene7452	1.552e-97	331.0	COG0410@1|root,COG0410@2|Bacteria,2GKSQ@201174|Actinobacteria	201174|Actinobacteria	E	ABC transporter	livF	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
REGS3_k127_4301868_9	1306174.JODP01000013_gene7453	2.414e-106	358.0	COG0411@1|root,COG0411@2|Bacteria,2GMEE@201174|Actinobacteria	201174|Actinobacteria	E	ABC transporter	livG	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
REGS3_k127_4301868_7	1306174.JODP01000013_gene7454	1.182e-107	361.0	COG4177@1|root,COG4177@2|Bacteria,2GJB3@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the binding-protein-dependent transport system permease family	livM	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
REGS3_k127_4301868_8	1121946.AUAX01000024_gene7587	1.617e-107	359.0	COG0559@1|root,COG0559@2|Bacteria,2GMAY@201174|Actinobacteria,4D95X@85008|Micromonosporales	201174|Actinobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
REGS3_k127_4301868_4	1121946.AUAX01000024_gene7588	2.569e-131	434.0	COG0683@1|root,COG0683@2|Bacteria	2|Bacteria	E	ABC-type branched-chain amino acid transport systems, periplasmic component	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
REGS3_k127_4301868_15	1380390.JIAT01000012_gene2889	1.62e-33	139.0	COG0406@1|root,COG0406@2|Bacteria,2HUBQ@201174|Actinobacteria,4CQ1Z@84995|Rubrobacteria	201174|Actinobacteria	G	Phosphoglycerate mutase family	-	-	5.4.2.12	ko:K15634	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
REGS3_k127_4301868_3	1313172.YM304_21870	2.39e-135	437.0	COG2070@1|root,COG2070@2|Bacteria,2GKA6@201174|Actinobacteria	201174|Actinobacteria	T	2-nitropropane dioxygenase	fabK	-	1.3.1.9	ko:K02371	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00083	R04429,R04724,R04955,R04958,R04961,R04966,R04969,R07765	RC00052,RC00076	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	NMO
REGS3_k127_4301868_13	1313172.YM304_24730	1.314e-61	224.0	COG1612@1|root,COG1612@2|Bacteria,2GJQX@201174|Actinobacteria,4CN5J@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Cytochrome oxidase assembly protein	-	-	-	ko:K02259	ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714	M00154	R07412	RC00769	ko00000,ko00001,ko00002,ko03029	3.D.4.4	-	-	COX15-CtaA
REGS3_k127_4301868_1	1313172.YM304_24720	9.547e-140	454.0	2BYTM@1|root,2Z7KC@2|Bacteria,2GJ6K@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_4301868_6	1313172.YM304_24710	2.622e-122	396.0	COG1028@1|root,COG1028@2|Bacteria,2GK20@201174|Actinobacteria	201174|Actinobacteria	IQ	Short-chain dehydrogenase reductase sdr	-	-	1.1.1.100,1.1.1.69	ko:K00046,ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
REGS3_k127_4301868_11	1313172.YM304_31290	1.012e-94	319.0	COG1028@1|root,COG1028@2|Bacteria,2GK20@201174|Actinobacteria	201174|Actinobacteria	IQ	Short-chain dehydrogenase reductase sdr	-	-	1.1.1.100,1.1.1.69	ko:K00046,ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
REGS3_k127_4301868_14	356851.JOAN01000008_gene2972	1.896e-44	175.0	COG1309@1|root,COG1309@2|Bacteria,2GP3D@201174|Actinobacteria,4DD5T@85008|Micromonosporales	201174|Actinobacteria	K	BetI-type transcriptional repressor, C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_6,TetR_N
REGS3_k127_4301868_16	1313172.YM304_24690	2.539e-25	118.0	COG3631@1|root,COG3631@2|Bacteria	2|Bacteria	S	light absorption	-	-	-	-	-	-	-	-	-	-	-	-	Abi_2,SnoaL_2,SnoaL_4
REGS3_k127_4301868_18	1283299.AUKG01000003_gene447	0.0008255	49.0	2BRCF@1|root,32KB3@2|Bacteria,2HQNW@201174|Actinobacteria,4CS9V@84995|Rubrobacteria	84995|Rubrobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_4301868_0	1313172.YM304_24680	1.849e-163	521.0	COG2230@1|root,COG2230@2|Bacteria,2H060@201174|Actinobacteria	201174|Actinobacteria	M	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
REGS3_k127_4301868_12	1313172.YM304_24670	3.698e-85	288.0	COG0406@1|root,COG0406@2|Bacteria	2|Bacteria	G	alpha-ribazole phosphatase activity	gpm	-	3.1.3.73,5.4.2.12	ko:K02226,ko:K15634	ko00010,ko00260,ko00680,ko00860,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map00860,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00122	R01518,R04594,R11173	RC00017,RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
REGS3_k127_4301868_17	1313172.YM304_24660	3.649e-20	96.0	COG4061@1|root,COG4061@2|Bacteria	2|Bacteria	H	5-methyl-5,6,7,8-tetrahydromethanopterin-dependent methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF4190
REGS3_k127_4310743_3	1229780.BN381_450018	2.505e-68	242.0	COG2148@1|root,COG2148@2|Bacteria,2GK0M@201174|Actinobacteria,3UXA2@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	M	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	rfbP	-	-	-	-	-	-	-	-	-	-	-	Bac_transf,CoA_binding_3
REGS3_k127_4310743_4	243233.MCA1433	6.51e-61	228.0	COG0438@1|root,COG0438@2|Bacteria,1MVKK@1224|Proteobacteria,1RQ8J@1236|Gammaproteobacteria,1XFN6@135618|Methylococcales	135618|Methylococcales	M	Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
REGS3_k127_4310743_0	485913.Krac_2410	5.525e-193	632.0	COG3250@1|root,COG3250@2|Bacteria,2G5R6@200795|Chloroflexi	2|Bacteria	G	glycoside hydrolase family 2 sugar binding	manB3	-	3.2.1.25	ko:K01192	ko00511,ko04142,map00511,map04142	-	-	-	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_2
REGS3_k127_4310743_2	1828.JOKB01000003_gene2396	4.017e-81	281.0	2DBM2@1|root,2Z9WS@2|Bacteria,2II8P@201174|Actinobacteria,4FXWE@85025|Nocardiaceae	201174|Actinobacteria	S	Domain of unknown function (DUF1839)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1839
REGS3_k127_4310743_1	1101192.KB910516_gene2865	7.81e-100	334.0	COG0172@1|root,COG0172@2|Bacteria,1PHJG@1224|Proteobacteria,2TUT6@28211|Alphaproteobacteria,1JQSJ@119045|Methylobacteriaceae	28211|Alphaproteobacteria	J	seryl-tRNA synthetase	MA20_23120	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_4310743_5	1380390.JIAT01000009_gene1690	1.484e-59	213.0	COG1960@1|root,COG1960@2|Bacteria,2HGF7@201174|Actinobacteria,4CS8G@84995|Rubrobacteria	84995|Rubrobacteria	I	Acyl-CoA dehydrogenase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_N
REGS3_k127_4317996_2	1122182.KB903814_gene3506	2.363e-29	136.0	COG2373@1|root,COG2373@2|Bacteria	2|Bacteria	U	Large extracellular alpha-helical protein	-	-	-	ko:K12548	-	-	-	-	ko00000	-	-	-	CHU_C,Calx-beta,DUF11,IgGFc_binding,SprB,fn3
REGS3_k127_4317996_3	397945.Aave_4277	8.739e-11	75.0	COG1361@1|root,COG1361@2|Bacteria,1R5G4@1224|Proteobacteria,2VP03@28216|Betaproteobacteria,4AHHC@80864|Comamonadaceae	28216|Betaproteobacteria	M	Domain of unknown function DUF11	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,SdrD_B
REGS3_k127_4317996_1	1211815.CBYP010000052_gene764	1.876e-77	276.0	2AUNZ@1|root,31KBW@2|Bacteria,2GP4I@201174|Actinobacteria,4ESY9@85013|Frankiales	201174|Actinobacteria	S	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	DUF2786
REGS3_k127_4317996_0	675635.Psed_0041	4.39e-136	442.0	COG1914@1|root,COG1914@2|Bacteria,2GJSM@201174|Actinobacteria,4E050@85010|Pseudonocardiales	201174|Actinobacteria	P	Natural resistance-associated macrophage protein	-	-	-	-	-	-	-	-	-	-	-	-	Nramp
REGS3_k127_4323694_11	1313172.YM304_14810	4.458e-28	116.0	COG0822@1|root,COG0822@2|Bacteria,2IHY9@201174|Actinobacteria,4CN20@84992|Acidimicrobiia	84992|Acidimicrobiia	C	NifU-like N terminal domain	-	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
REGS3_k127_4323694_6	1341646.CBMO010000137_gene2322	1.201e-63	231.0	COG1028@1|root,COG1028@2|Bacteria,2GJ1F@201174|Actinobacteria,236RZ@1762|Mycobacteriaceae	201174|Actinobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
REGS3_k127_4323694_2	298654.FraEuI1c_1369	5.883e-189	603.0	COG0318@1|root,COG0318@2|Bacteria,2GJA2@201174|Actinobacteria,4EUMS@85013|Frankiales	201174|Actinobacteria	IQ	AMP-binding enzyme C-terminal domain	fadD19	GO:0001676,GO:0003674,GO:0003824,GO:0004467,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009273,GO:0009605,GO:0009607,GO:0009987,GO:0015645,GO:0016405,GO:0016874,GO:0016877,GO:0016878,GO:0019752,GO:0030312,GO:0032787,GO:0042546,GO:0042579,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044085,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051087,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0071554,GO:0071704,GO:0071766,GO:0071840,GO:0071944,GO:0075136,GO:1901576	6.2.1.42	ko:K00666,ko:K18688	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
REGS3_k127_4323694_3	298654.FraEuI1c_4779	4.537e-159	511.0	COG2159@1|root,COG2159@2|Bacteria,2GMRC@201174|Actinobacteria	201174|Actinobacteria	I	Pfam Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
REGS3_k127_4323694_9	1313172.YM304_14800	5.22e-43	165.0	COG2050@1|root,COG2050@2|Bacteria	2|Bacteria	Q	thiolester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
REGS3_k127_4323694_8	1313172.YM304_14780	1.584e-58	209.0	COG2606@1|root,COG2606@2|Bacteria,2HH14@201174|Actinobacteria,4CP1D@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Aminoacyl-tRNA editing domain	-	-	-	-	-	-	-	-	-	-	-	-	tRNA_edit
REGS3_k127_4323694_5	491915.Aflv_2464	1.439e-68	242.0	COG0396@1|root,COG0396@2|Bacteria,1TQ98@1239|Firmicutes,4HAD9@91061|Bacilli,21W2I@150247|Anoxybacillus	91061|Bacilli	O	ATPases associated with a variety of cellular activities	sufC	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
REGS3_k127_4323694_12	1449346.JQMO01000002_gene1961	4.437e-22	100.0	COG2146@1|root,COG2146@2|Bacteria,2IQK7@201174|Actinobacteria,2M3BP@2063|Kitasatospora	201174|Actinobacteria	P	Rieske-like [2Fe-2S] domain	hcaC	-	-	ko:K05710	ko00360,ko01120,ko01220,map00360,map01120,map01220	M00545	R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002	-	-	-	Rieske
REGS3_k127_4323694_7	525904.Tter_1697	7.195e-61	224.0	COG0719@1|root,COG0719@2|Bacteria,2NPGC@2323|unclassified Bacteria	2|Bacteria	O	FeS assembly protein SufD	sufD	GO:0006790,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0040007,GO:0043207,GO:0044085,GO:0044237,GO:0044403,GO:0044419,GO:0050896,GO:0051186,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0071840,GO:0075136	-	ko:K07033,ko:K09015	-	-	-	-	ko00000	-	-	iB21_1397.B21_01640,iECBD_1354.ECBD_1964,iECB_1328.ECB_01650,iECD_1391.ECD_01650,iUMNK88_1353.UMNK88_2144	UPF0051
REGS3_k127_4323694_10	1313172.YM304_14750	1.318e-40	154.0	2FF8Q@1|root,3476J@2|Bacteria,2H7PN@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_4323694_0	1121877.JQKF01000001_gene1306	2.295e-240	749.0	COG0719@1|root,COG0719@2|Bacteria,2GKCZ@201174|Actinobacteria,4CMQU@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Uncharacterized protein family (UPF0051)	-	-	-	ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
REGS3_k127_4323694_1	1313172.YM304_30830	9.613e-235	731.0	COG0137@1|root,COG0137@2|Bacteria,2GK96@201174|Actinobacteria,4CNB6@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Belongs to the argininosuccinate synthase family. Type	argG	-	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
REGS3_k127_4323694_4	1313172.YM304_30850	9.11e-81	273.0	COG0624@1|root,COG0624@2|Bacteria,2GMH2@201174|Actinobacteria	201174|Actinobacteria	E	peptidase	-	-	3.4.17.11	ko:K01295	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
REGS3_k127_4328825_3	1313172.YM304_04960	2.733e-75	264.0	COG3253@1|root,COG3253@2|Bacteria,2HG3V@201174|Actinobacteria,4CMZQ@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Chlorite dismutase	-	-	-	-	-	-	-	-	-	-	-	-	Chlor_dismutase
REGS3_k127_4328825_1	1313172.YM304_04940	1.929e-106	351.0	COG1526@1|root,COG1526@2|Bacteria,2GKWC@201174|Actinobacteria,4CN5S@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH	fdhD	-	-	ko:K02379	-	-	-	-	ko00000	-	-	-	FdhD-NarQ
REGS3_k127_4328825_4	179408.Osc7112_3402	9.988e-59	220.0	COG0580@1|root,COG0580@2|Bacteria,1G0AW@1117|Cyanobacteria,1H75V@1150|Oscillatoriales	1117|Cyanobacteria	G	Belongs to the MIP aquaporin (TC 1.A.8) family	aqpZ	-	-	ko:K06188	-	-	-	-	ko00000,ko02000	1.A.8	-	iJN678.apqZ	MIP
REGS3_k127_4328825_2	1313172.YM304_36860	2.583e-81	274.0	COG0652@1|root,COG0652@2|Bacteria,2GN8G@201174|Actinobacteria,4CN2J@84992|Acidimicrobiia	84992|Acidimicrobiia	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	-	-	5.2.1.8	ko:K01802,ko:K03768	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Pro_isomerase
REGS3_k127_4328825_0	1313172.YM304_36840	4.137e-121	396.0	COG3214@1|root,COG3214@2|Bacteria,2GJM7@201174|Actinobacteria	201174|Actinobacteria	J	protein conserved in bacteria	-	-	-	ko:K09927	-	-	-	-	ko00000	-	-	-	HTH_42
REGS3_k127_4342655_8	1123023.JIAI01000049_gene9274	7.939e-48	173.0	COG1487@1|root,COG1487@2|Bacteria,2IMGJ@201174|Actinobacteria	201174|Actinobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0006139,GO:0006417,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016070,GO:0016787,GO:0016788,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360,GO:2000112,GO:2000113	-	-	-	-	-	-	-	-	-	-	PIN
REGS3_k127_4342655_12	1048339.KB913029_gene1934	8.248e-37	145.0	COG4747@1|root,COG4747@2|Bacteria,2GZWK@201174|Actinobacteria	201174|Actinobacteria	S	ACT domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_4342655_6	525909.Afer_1598	1.203e-63	226.0	COG4186@1|root,COG4186@2|Bacteria,2IRYE@201174|Actinobacteria	201174|Actinobacteria	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Metallophos_2
REGS3_k127_4342655_1	1121272.KB903272_gene496	2.199e-160	517.0	COG1249@1|root,COG1249@2|Bacteria,2GJJK@201174|Actinobacteria,4D9EC@85008|Micromonosporales	201174|Actinobacteria	C	FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim
REGS3_k127_4342655_13	246200.SPO1189	1.687e-36	150.0	COG0697@1|root,COG0697@2|Bacteria,1PK9V@1224|Proteobacteria,2V9XA@28211|Alphaproteobacteria,4NDN0@97050|Ruegeria	28211|Alphaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
REGS3_k127_4342655_7	710686.Mycsm_03134	7.822e-56	215.0	COG0741@1|root,COG0741@2|Bacteria,2IBCH@201174|Actinobacteria,2359I@1762|Mycobacteriaceae	201174|Actinobacteria	M	transglycosylase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1460,NLPC_P60,SLT,SLT_2
REGS3_k127_4342655_3	1313172.YM304_10800	2.076e-120	402.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
REGS3_k127_4342655_9	1313172.YM304_02800	4.733e-43	168.0	COG1978@1|root,COG1978@2|Bacteria,2GQU6@201174|Actinobacteria	201174|Actinobacteria	S	Glycine/sarcosine/betaine reductase selenoprotein B (GRDB)	-	-	1.21.4.1,1.21.4.2	ko:K10672,ko:K10794	ko00330,map00330	-	R02825	RC00790	ko00000,ko00001,ko01000	-	-	-	GRDB
REGS3_k127_4342655_5	1313172.YM304_02800	5.436e-64	226.0	COG1978@1|root,COG1978@2|Bacteria,2GQU6@201174|Actinobacteria	201174|Actinobacteria	S	Glycine/sarcosine/betaine reductase selenoprotein B (GRDB)	-	-	1.21.4.1,1.21.4.2	ko:K10672,ko:K10794	ko00330,map00330	-	R02825	RC00790	ko00000,ko00001,ko01000	-	-	-	GRDB
REGS3_k127_4342655_2	1229780.BN381_60086	1.119e-159	512.0	COG0596@1|root,COG0596@2|Bacteria,2GK79@201174|Actinobacteria	201174|Actinobacteria	K	epoxide hydrolase	-	-	3.3.2.9	ko:K01253	ko00980,ko04976,ko05204,map00980,map04976,map05204	-	R07013,R07014,R07027,R07071,R07072,R07082,R09410,R09417,R09443	RC01447,RC01728,RC01764,RC02528	ko00000,ko00001,ko01000,ko01002	-	-	-	EHN
REGS3_k127_4342655_10	1313172.YM304_32980	2.136e-37	145.0	COG1430@1|root,COG1430@2|Bacteria,2IKSE@201174|Actinobacteria	201174|Actinobacteria	S	Uncharacterized ACR, COG1430	-	-	-	ko:K09005	-	-	-	-	ko00000	-	-	-	DUF192
REGS3_k127_4342655_4	1313172.YM304_32990	4.445e-89	301.0	COG0313@1|root,COG0313@2|Bacteria,2GJ9Q@201174|Actinobacteria,4CNAK@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Tetrapyrrole (Corrin/Porphyrin) Methylases	rsmI	-	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
REGS3_k127_4342655_11	710696.Intca_2685	2.862e-37	152.0	COG1946@1|root,COG1946@2|Bacteria,2GMZB@201174|Actinobacteria,4FG7M@85021|Intrasporangiaceae	201174|Actinobacteria	I	Thioesterase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT_3
REGS3_k127_4342655_0	1313172.YM304_33020	4.046e-243	756.0	COG0143@1|root,COG0143@2|Bacteria,2GK4S@201174|Actinobacteria,4CMP6@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1g
REGS3_k127_4373659_2	1313172.YM304_21340	3.288e-139	447.0	COG0331@1|root,COG0331@2|Bacteria,2GME0@201174|Actinobacteria,4CMPZ@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Acyl transferase domain	-	-	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
REGS3_k127_4373659_1	1313172.YM304_21330	5.362e-144	462.0	COG0332@1|root,COG0332@2|Bacteria,2GJP8@201174|Actinobacteria,4CMQV@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
REGS3_k127_4373659_5	1313172.YM304_21320	2.725e-98	337.0	COG1028@1|root,COG1028@2|Bacteria,2GK6C@201174|Actinobacteria,4CN06@84992|Acidimicrobiia	84992|Acidimicrobiia	IQ	KR domain	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
REGS3_k127_4373659_8	1313172.YM304_21310	2.04e-25	109.0	COG0236@1|root,COG0236@2|Bacteria,2HGA0@201174|Actinobacteria,4CN8U@84992|Acidimicrobiia	84992|Acidimicrobiia	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	-	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
REGS3_k127_4373659_0	1313172.YM304_21300	1.234e-161	523.0	COG0304@1|root,COG0304@2|Bacteria,2GIY4@201174|Actinobacteria,4CMVV@84992|Acidimicrobiia	84992|Acidimicrobiia	IQ	Beta-ketoacyl synthase, C-terminal domain	-	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
REGS3_k127_4373659_6	1313172.YM304_21280	5.067e-60	216.0	COG0764@1|root,COG0764@2|Bacteria,2GQWT@201174|Actinobacteria,4CN5K@84992|Acidimicrobiia	84992|Acidimicrobiia	I	FabA-like domain	fabZ	-	4.2.1.59	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
REGS3_k127_4373659_7	1313172.YM304_17780	4.59e-53	191.0	COG1225@1|root,COG1225@2|Bacteria,2IHZ6@201174|Actinobacteria,4CN8N@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Redoxin	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
REGS3_k127_4373659_3	1313172.YM304_24320	3.114e-116	380.0	COG0159@1|root,COG0159@2|Bacteria,2GN6T@201174|Actinobacteria,4CMZW@84992|Acidimicrobiia	84992|Acidimicrobiia	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
REGS3_k127_4373659_4	1313172.YM304_24310	3.801e-107	350.0	COG0133@1|root,COG0133@2|Bacteria,2GM7Z@201174|Actinobacteria,4CMR9@84992|Acidimicrobiia	84992|Acidimicrobiia	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
REGS3_k127_4392339_42	1382359.JIAL01000001_gene1890	1.792e-32	130.0	COG3393@1|root,COG3393@2|Bacteria	2|Bacteria	S	Acetyltransferase (GNAT) family	MA20_27790	-	-	ko:K06976	-	-	-	-	ko00000	-	-	-	Acetyltransf_1,FR47
REGS3_k127_4392339_27	1298858.AUEL01000012_gene5201	1.999e-70	249.0	COG1028@1|root,COG1028@2|Bacteria,1MW9A@1224|Proteobacteria,2TRFW@28211|Alphaproteobacteria,43I3E@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	IQ	with different specificities (related to short-chain alcohol	ygfF	-	1.1.1.47	ko:K00034	ko00030,ko01120,ko01200,map00030,map01120,map01200	-	R01520,R01521	RC00066	ko00000,ko00001,ko01000	-	-	-	adh_short_C2
REGS3_k127_4392339_4	1123320.KB889747_gene7182	5.385e-156	509.0	COG1804@1|root,COG1804@2|Bacteria,2GMJ9@201174|Actinobacteria	201174|Actinobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
REGS3_k127_4392339_2	1282876.BAOK01000001_gene3037	1.055e-180	578.0	COG0318@1|root,COG0318@2|Bacteria,1MUIC@1224|Proteobacteria,2TUFX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	IQ	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II	-	-	6.2.1.7	ko:K15868	ko00121,map00121	-	-	-	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C
REGS3_k127_4392339_34	1229780.BN381_300012	4.397e-44	166.0	2EACJ@1|root,334GH@2|Bacteria,2IG8C@201174|Actinobacteria	201174|Actinobacteria	S	Limonene-12-epoxide hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	LEH,SnoaL_2
REGS3_k127_4392339_16	525368.HMPREF0591_3546	2.501e-103	344.0	COG1028@1|root,COG1028@2|Bacteria,2GIYQ@201174|Actinobacteria,233HK@1762|Mycobacteriaceae	201174|Actinobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
REGS3_k127_4392339_32	1045009.AFXQ01000024_gene924	1.163e-49	195.0	COG0477@1|root,COG0477@2|Bacteria,2GK06@201174|Actinobacteria	201174|Actinobacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
REGS3_k127_4392339_23	468556.AQYG01000051_gene2372	3.162e-80	277.0	COG1028@1|root,COG1028@2|Bacteria,2GJU1@201174|Actinobacteria,4GAJG@85026|Gordoniaceae	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	hdhA	GO:0002682,GO:0002684,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009605,GO:0009607,GO:0016020,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0044464,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052564,GO:0052572,GO:0065007,GO:0071944,GO:0075136	1.1.1.159	ko:K00076	ko00121,map00121	-	-	-	ko00000,ko00001,ko01000	-	-	-	adh_short_C2
REGS3_k127_4392339_41	1123320.KB889697_gene8963	1.613e-32	131.0	COG2030@1|root,COG2030@2|Bacteria,2IHRG@201174|Actinobacteria	201174|Actinobacteria	I	dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
REGS3_k127_4392339_7	1463820.JOGW01000002_gene5985	2.111e-134	437.0	COG2070@1|root,COG2070@2|Bacteria,2GKA6@201174|Actinobacteria	201174|Actinobacteria	T	2-nitropropane dioxygenase	fabK	GO:0000166,GO:0001775,GO:0002252,GO:0002263,GO:0002274,GO:0002275,GO:0002283,GO:0002366,GO:0002376,GO:0002443,GO:0002444,GO:0002446,GO:0003674,GO:0003824,GO:0003938,GO:0005488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006887,GO:0006955,GO:0007623,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0012505,GO:0016192,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030141,GO:0031410,GO:0031974,GO:0031982,GO:0031983,GO:0032940,GO:0034404,GO:0034641,GO:0034654,GO:0034774,GO:0036094,GO:0036230,GO:0042119,GO:0042278,GO:0042451,GO:0042455,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043299,GO:0043312,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044433,GO:0044444,GO:0044446,GO:0044464,GO:0045055,GO:0045321,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0046903,GO:0048511,GO:0050896,GO:0051179,GO:0051234,GO:0055086,GO:0055114,GO:0060205,GO:0070013,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097708,GO:0099503,GO:0101002,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659,GO:1904813	1.13.12.16	ko:K00459	ko00910,map00910	-	R00025	RC02541,RC02759	ko00000,ko00001,ko01000	-	-	-	NMO
REGS3_k127_4392339_20	471852.Tcur_4620	3.984e-89	301.0	COG2057@1|root,COG2057@2|Bacteria,2GMA1@201174|Actinobacteria,4EIFA@85012|Streptosporangiales	201174|Actinobacteria	I	Coenzyme A transferase	-	-	2.8.3.12	ko:K01040	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
REGS3_k127_4392339_10	469383.Cwoe_2354	8.499e-122	409.0	COG1788@1|root,COG1788@2|Bacteria,2GK61@201174|Actinobacteria	201174|Actinobacteria	I	coenzyme A transferase	cotA	-	2.8.3.12	ko:K01039	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
REGS3_k127_4392339_12	469383.Cwoe_2352	1.083e-112	368.0	COG1024@1|root,COG1024@2|Bacteria,2GN54@201174|Actinobacteria	201174|Actinobacteria	I	Enoyl-CoA hydratase	echA20	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
REGS3_k127_4392339_21	1245471.PCA10_13800	7.166e-87	294.0	COG1028@1|root,COG1028@2|Bacteria,1P1U4@1224|Proteobacteria,1RR3M@1236|Gammaproteobacteria,1YJ2B@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
REGS3_k127_4392339_35	1499967.BAYZ01000104_gene3692	3.544e-42	172.0	COG0738@1|root,COG0738@2|Bacteria	2|Bacteria	G	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
REGS3_k127_4392339_5	882083.SacmaDRAFT_2038	1.771e-139	460.0	COG4799@1|root,COG4799@2|Bacteria,2GNV2@201174|Actinobacteria	201174|Actinobacteria	I	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)	accD4_2	-	-	-	-	-	-	-	-	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,Carboxyl_trans
REGS3_k127_4392339_29	1313172.YM304_23240	2.024e-58	208.0	COG2249@1|root,COG2249@2|Bacteria	2|Bacteria	K	NAD(P)H dehydrogenase (quinone) activity	-	-	1.6.5.2	ko:K00355	ko00130,ko01110,ko05200,ko05225,ko05418,map00130,map01110,map05200,map05225,map05418	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	Flavodoxin_2
REGS3_k127_4392339_31	1320556.AVBP01000019_gene1333	1.39e-52	198.0	COG2249@1|root,COG2249@2|Bacteria,1REE1@1224|Proteobacteria,2U91M@28211|Alphaproteobacteria,43MR5@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	NADPH dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_2
REGS3_k127_4392339_13	1123023.JIAI01000001_gene6566	1.868e-109	362.0	COG2313@1|root,COG2313@2|Bacteria,2GK19@201174|Actinobacteria,4DZU4@85010|Pseudonocardiales	201174|Actinobacteria	Q	Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway	psuG	-	4.2.1.70	ko:K16329	ko00240,map00240	-	R01055	RC00432,RC00433	ko00000,ko00001,ko01000	-	-	-	Indigoidine_A
REGS3_k127_4392339_45	1323361.JPOC01000069_gene1425	4.981e-29	121.0	COG3631@1|root,COG3631@2|Bacteria,2IM62@201174|Actinobacteria,4G1CB@85025|Nocardiaceae	201174|Actinobacteria	S	Domain of unknown function (DUF4440)	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
REGS3_k127_4392339_24	1313172.YM304_23220	7.914e-80	280.0	COG2265@1|root,COG2265@2|Bacteria,2GIR3@201174|Actinobacteria	201174|Actinobacteria	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	rumA	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
REGS3_k127_4392339_14	1313172.YM304_23000	1.637e-107	352.0	COG0036@1|root,COG0036@2|Bacteria,2GJZ9@201174|Actinobacteria,4CMZI@84992|Acidimicrobiia	84992|Acidimicrobiia	G	Ribulose-phosphate 3 epimerase family	rpe	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
REGS3_k127_4392339_15	1313172.YM304_18790	8.154e-106	349.0	COG1024@1|root,COG1024@2|Bacteria,2I2PC@201174|Actinobacteria,4CNAF@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Enoyl-CoA hydratase/isomerase	-	-	5.3.3.18	ko:K15866	ko00360,ko01120,map00360,map01120	-	R09837,R09839	RC00004,RC00326,RC02689,RC03003	ko00000,ko00001,ko01000	-	-	-	ECH_1
REGS3_k127_4392339_22	1313172.YM304_05280	1.06e-83	303.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,Laminin_G_3,PKD,SprB
REGS3_k127_4392339_43	1229780.BN381_330042	6.068e-32	129.0	COG0792@1|root,COG0792@2|Bacteria,2IQ3X@201174|Actinobacteria,3UWWQ@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	L	Uncharacterised protein family UPF0102	yraN	-	-	ko:K07460	-	-	-	-	ko00000	-	-	-	UPF0102
REGS3_k127_4392339_40	1045009.AFXQ01000021_gene11	9.817e-34	132.0	2AFXT@1|root,3161G@2|Bacteria,2IKPZ@201174|Actinobacteria,1W9RU@1268|Micrococcaceae	201174|Actinobacteria	S	Protein of unknown function (DUF2469)	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF2469
REGS3_k127_4392339_33	1313172.YM304_18770	6.742e-48	179.0	COG0335@1|root,COG0335@2|Bacteria,2IHRT@201174|Actinobacteria,4CN2N@84992|Acidimicrobiia	84992|Acidimicrobiia	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site	rplS	-	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
REGS3_k127_4392339_11	1313172.YM304_18760	3.251e-121	392.0	COG0336@1|root,COG0336@2|Bacteria,2GJ1G@201174|Actinobacteria,4CMZ9@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Belongs to the RNA methyltransferase TrmD family	trmD	-	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	tRNA_m1G_MT
REGS3_k127_4392339_36	1313172.YM304_18750	4.564e-41	158.0	COG0806@1|root,COG0806@2|Bacteria,2HGD9@201174|Actinobacteria,4CNBG@84992|Acidimicrobiia	84992|Acidimicrobiia	J	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes	rimM	-	-	ko:K02860	-	-	-	-	ko00000,ko03009	-	-	-	RimM
REGS3_k127_4392339_46	1313172.YM304_18740	1.314e-21	100.0	COG1837@1|root,COG1837@2|Bacteria	2|Bacteria	L	Belongs to the UPF0109 family	CP_0960	GO:0008150,GO:0040007	-	ko:K06960	-	-	-	-	ko00000	-	-	-	KH_4
REGS3_k127_4392339_39	1313172.YM304_18730	1.252e-35	138.0	COG0228@1|root,COG0228@2|Bacteria,2IKU0@201174|Actinobacteria,4CNAD@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Ribosomal protein S16	rpsP	-	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
REGS3_k127_4392339_1	1313172.YM304_18720	6.809e-209	657.0	COG0541@1|root,COG0541@2|Bacteria,2GK4R@201174|Actinobacteria,4CMPN@84992|Acidimicrobiia	84992|Acidimicrobiia	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
REGS3_k127_4392339_8	1313172.YM304_18700	3.307e-131	428.0	COG0552@1|root,COG0552@2|Bacteria,2GJQH@201174|Actinobacteria,4CMY6@84992|Acidimicrobiia	84992|Acidimicrobiia	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54
REGS3_k127_4392339_19	1894.JOER01000003_gene2830	1.614e-92	312.0	COG1177@1|root,COG1177@2|Bacteria,2GJ6Q@201174|Actinobacteria	201174|Actinobacteria	E	ABC-type spermidine putrescine transport system, permease component II	-	-	-	ko:K02053	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	BPD_transp_1
REGS3_k127_4392339_18	1120949.KB903350_gene8124	8.246e-94	316.0	COG1176@1|root,COG1176@2|Bacteria,2GJ5G@201174|Actinobacteria,4DC77@85008|Micromonosporales	201174|Actinobacteria	E	ABC-type spermidine putrescine transport system, permease component I	-	-	-	ko:K02054	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	BPD_transp_1
REGS3_k127_4392339_3	1440774.Y900_021165	2.347e-168	537.0	COG0687@1|root,COG0687@2|Bacteria,2HQAG@201174|Actinobacteria,236G3@1762|Mycobacteriaceae	201174|Actinobacteria	E	Bacterial extracellular solute-binding protein	-	-	-	ko:K02055	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	SBP_bac_8
REGS3_k127_4392339_9	1125971.ASJB01000008_gene2657	1.579e-126	417.0	COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria,4E01K@85010|Pseudonocardiales	201174|Actinobacteria	E	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	-	-	-	ko:K02052	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	ABC_tran,TOBE_2
REGS3_k127_4392339_0	1313172.YM304_18690	0.0	1394.0	COG1196@1|root,COG1196@2|Bacteria,2GK93@201174|Actinobacteria,4CMQE@84992|Acidimicrobiia	84992|Acidimicrobiia	D	RecF/RecN/SMC N terminal domain	-	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N
REGS3_k127_4392339_17	1313172.YM304_18680	1.329e-102	347.0	COG0266@1|root,COG0266@2|Bacteria,2GJNT@201174|Actinobacteria,4CN5C@84992|Acidimicrobiia	84992|Acidimicrobiia	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	mutM	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
REGS3_k127_4392339_26	1313172.YM304_18670	2.426e-75	262.0	COG0571@1|root,COG0571@2|Bacteria,2GKER@201174|Actinobacteria,4CN7Y@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	rnc	-	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
REGS3_k127_4392339_44	1313172.YM304_18660	2.707e-29	119.0	COG0236@1|root,COG0236@2|Bacteria,2HG9V@201174|Actinobacteria,4CN8D@84992|Acidimicrobiia	84992|Acidimicrobiia	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	-	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
REGS3_k127_4392339_6	1313172.YM304_18650	1.976e-137	446.0	COG0416@1|root,COG0416@2|Bacteria,2I8WT@201174|Actinobacteria,4CMRM@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA	plsX	-	2.3.1.15	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_synthesis
REGS3_k127_4392339_48	1313172.YM304_18640	9.751e-21	93.0	COG0333@1|root,COG0333@2|Bacteria	2|Bacteria	J	Belongs to the bacterial ribosomal protein bL32 family	rpmF	GO:0000027,GO:0000302,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006950,GO:0006979,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042221,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1901700,GO:1990904	-	ko:K02911	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_L32p
REGS3_k127_4392339_37	1313172.YM304_18630	1.709e-40	156.0	COG1399@1|root,COG1399@2|Bacteria,2HGH0@201174|Actinobacteria,4CNEE@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Uncharacterized ACR, COG1399	-	-	-	ko:K07040	-	-	-	-	ko00000	-	-	-	DUF177
REGS3_k127_4392339_25	1313172.YM304_18600	2.819e-76	261.0	COG0711@1|root,COG0711@2|Bacteria,2HG9T@201174|Actinobacteria,4CN89@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_4392339_30	1313172.YM304_18590	1.797e-55	198.0	COG0669@1|root,COG0669@2|Bacteria,2GN1S@201174|Actinobacteria,4CN4E@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	-	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
REGS3_k127_4392339_28	1313172.YM304_18580	2.355e-61	217.0	COG0742@1|root,COG0742@2|Bacteria,2GQ3G@201174|Actinobacteria,4CN8I@84992|Acidimicrobiia	84992|Acidimicrobiia	L	Conserved hypothetical protein 95	-	-	2.1.1.171	ko:K08316	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Cons_hypoth95
REGS3_k127_4392339_47	1445613.JALM01000074_gene6678	2.703e-21	97.0	COG0642@1|root,COG0642@2|Bacteria,2GJIV@201174|Actinobacteria,4DXCC@85010|Pseudonocardiales	201174|Actinobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
REGS3_k127_4433616_2	463191.SSEG_07370	1.448e-84	289.0	COG0559@1|root,COG0559@2|Bacteria,2GJM0@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
REGS3_k127_4433616_0	1380390.JIAT01000009_gene1443	6.776e-102	348.0	COG0683@1|root,COG0683@2|Bacteria,2GJ2V@201174|Actinobacteria,4CTNJ@84995|Rubrobacteria	84995|Rubrobacteria	E	Periplasmic binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
REGS3_k127_4433616_3	1123020.AUIE01000005_gene4259	2.208e-53	198.0	COG2267@1|root,COG2267@2|Bacteria,1N9CI@1224|Proteobacteria	1224|Proteobacteria	I	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
REGS3_k127_4433616_1	1082933.MEA186_23196	1.864e-96	329.0	COG2141@1|root,COG2141@2|Bacteria,1MUTJ@1224|Proteobacteria,2TTZI@28211|Alphaproteobacteria,43I7M@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
REGS3_k127_4488405_2	44060.JODL01000002_gene2249	3.517e-34	144.0	COG1277@1|root,COG1277@2|Bacteria,2GP6D@201174|Actinobacteria	201174|Actinobacteria	S	ABC transporter (Permease)	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_4
REGS3_k127_4488405_0	591158.SSMG_04478	7.631e-88	301.0	COG1131@1|root,COG2936@1|root,COG1131@2|Bacteria,COG2936@2|Bacteria,2GN8P@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,PepX_C,Peptidase_S15
REGS3_k127_4488405_1	1146883.BLASA_1716	5.484e-45	172.0	COG3707@1|root,COG3707@2|Bacteria,2I2Q0@201174|Actinobacteria,4EVVD@85013|Frankiales	201174|Actinobacteria	T	ANTAR	-	-	-	-	-	-	-	-	-	-	-	-	ANTAR,GAF_2
REGS3_k127_4488405_4	1397527.Q670_15155	8.338e-06	49.0	COG2114@1|root,COG2114@2|Bacteria,1MV1V@1224|Proteobacteria,1RYBQ@1236|Gammaproteobacteria,1XHVD@135619|Oceanospirillales	135619|Oceanospirillales	T	COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP domain)	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc,MASE2
REGS3_k127_4488405_3	1128421.JAGA01000002_gene1525	1.14e-06	54.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23
REGS3_k127_4502064_4	1150599.MPHLEI_24464	5.261e-45	165.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2GMN4@201174|Actinobacteria,2337W@1762|Mycobacteriaceae	201174|Actinobacteria	H	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	ppsA	-	2.7.9.1,2.7.9.2	ko:K01006,ko:K01007,ko:K21787	ko00333,ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01130,ko01200,map00333,map00620,map00680,map00710,map00720,map01100,map01120,map01130,map01200	M00169,M00171,M00172,M00173,M00374,M00837,M00838	R00199,R00206,R11662,R11673	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
REGS3_k127_4502064_0	1430440.MGMSRv2_0206	3.494e-148	484.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TR2W@28211|Alphaproteobacteria,2JQI2@204441|Rhodospirillales	204441|Rhodospirillales	IQ	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II	-	-	-	ko:K18661	ko00280,map00280	-	R03383	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C
REGS3_k127_4502064_8	1121271.AUCM01000004_gene1241	2.709e-09	63.0	COG0694@1|root,COG0694@2|Bacteria,1MVQ1@1224|Proteobacteria,2TUD1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	COG0694 Thioredoxin-like proteins and domains	nifU	-	-	-	-	-	-	-	-	-	-	-	Nfu_N,NifU
REGS3_k127_4502064_5	1122138.AQUZ01000046_gene331	1.667e-27	121.0	COG0644@1|root,COG0644@2|Bacteria,2GUA3@201174|Actinobacteria,4DSWH@85009|Propionibacteriales	201174|Actinobacteria	C	oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_N
REGS3_k127_4502064_2	1242864.D187_006843	4.792e-70	254.0	COG2124@1|root,COG3239@1|root,COG2124@2|Bacteria,COG3239@2|Bacteria,1PP7Y@1224|Proteobacteria,42YWN@68525|delta/epsilon subdivisions,2WUKG@28221|Deltaproteobacteria,2YYFI@29|Myxococcales	28221|Deltaproteobacteria	I	Fatty acid desaturase	-	-	1.14.19.3	ko:K00508	ko00591,ko01100,map00591,map01100	-	R07063	RC00917	ko00000,ko00001,ko01000,ko01004	-	-	-	FA_desaturase
REGS3_k127_4502064_1	67373.JOBF01000005_gene2197	6.334e-103	353.0	COG0277@1|root,COG0277@2|Bacteria,2GK5U@201174|Actinobacteria	201174|Actinobacteria	C	PFAM FAD linked oxidase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
REGS3_k127_4502064_9	1077144.AGFF01000023_gene1383	1.52e-08	66.0	2DMG6@1|root,32RB5@2|Bacteria,2GMQI@201174|Actinobacteria	201174|Actinobacteria	S	MDMPI C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_C,MDMPI_N
REGS3_k127_4502064_3	1003195.SCAT_0316	1.174e-69	246.0	COG4291@1|root,COG4291@2|Bacteria,2GIW8@201174|Actinobacteria	201174|Actinobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF1345
REGS3_k127_4502064_7	1246448.ANAZ01000036_gene210	5.797e-10	60.0	COG1960@1|root,COG1960@2|Bacteria,2GJDT@201174|Actinobacteria,4EM59@85012|Streptosporangiales	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, middle domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
REGS3_k127_4511020_1	1120934.KB894405_gene5277	3.928e-60	222.0	2EIY5@1|root,33CPB@2|Bacteria,2I391@201174|Actinobacteria,4E3MI@85010|Pseudonocardiales	201174|Actinobacteria	S	Zinc finger domain	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_4511020_0	479431.Namu_1911	8.019e-119	415.0	COG2909@1|root,COG3629@1|root,COG2909@2|Bacteria,COG3629@2|Bacteria,2I348@201174|Actinobacteria,4EUJ7@85013|Frankiales	201174|Actinobacteria	K	PFAM transcriptional regulator domain protein	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,Trans_reg_C
REGS3_k127_4511020_2	102129.Lepto7375DRAFT_8031	3.537e-42	160.0	2ANY6@1|root,31DZ3@2|Bacteria,1G7AH@1117|Cyanobacteria	1117|Cyanobacteria	S	Domain of unknown function (DUF4280)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4280
REGS3_k127_4515107_10	512565.AMIS_23060	2.389e-43	162.0	COG0243@1|root,COG0243@2|Bacteria,2GNYQ@201174|Actinobacteria,4DI2D@85008|Micromonosporales	201174|Actinobacteria	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
REGS3_k127_4515107_7	1313172.YM304_26940	9.201e-59	213.0	COG1985@1|root,COG1985@2|Bacteria,2HGX9@201174|Actinobacteria,4CNXF@84992|Acidimicrobiia	84992|Acidimicrobiia	H	RibD C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
REGS3_k127_4515107_8	1313172.YM304_26950	2.782e-50	183.0	COG1327@1|root,COG1327@2|Bacteria,2IHU9@201174|Actinobacteria,4CN4B@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	-	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
REGS3_k127_4515107_13	1048834.TC41_2006	0.0004302	48.0	COG0791@1|root,COG1388@1|root,COG0791@2|Bacteria,COG1388@2|Bacteria,1TP24@1239|Firmicutes,4HA77@91061|Bacilli	91061|Bacilli	M	COG1388 FOG LysM repeat	-	-	-	ko:K19223,ko:K19224,ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	CBM50	-	Cu_amine_oxidN1,LysM,NLPC_P60,PG_binding_1
REGS3_k127_4515107_5	1313172.YM304_26970	6.899e-96	319.0	COG1974@1|root,COG1974@2|Bacteria,2GMBN@201174|Actinobacteria,4CN5D@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	-	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
REGS3_k127_4515107_12	1313172.YM304_26980	3.455e-22	107.0	2EQSP@1|root,33ICH@2|Bacteria,2GWX9@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_4515107_3	1313172.YM304_26990	4.915e-154	494.0	COG0436@1|root,COG0436@2|Bacteria,2H440@201174|Actinobacteria,4CMXW@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
REGS3_k127_4515107_2	1313172.YM304_27000	1.83e-191	616.0	COG2262@1|root,COG2262@2|Bacteria,2GK55@201174|Actinobacteria,4CMWR@84992|Acidimicrobiia	84992|Acidimicrobiia	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
REGS3_k127_4515107_6	1313172.YM304_27010	1.343e-80	277.0	COG0253@1|root,COG0253@2|Bacteria,2GKUD@201174|Actinobacteria,4CNYU@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF	-	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
REGS3_k127_4515107_4	1313172.YM304_27020	9.113e-109	361.0	COG0324@1|root,COG0324@2|Bacteria,2GKFT@201174|Actinobacteria,4CN5X@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	-	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
REGS3_k127_4515107_11	103733.JNYO01000082_gene4561	6.178e-24	112.0	COG0596@1|root,COG0596@2|Bacteria,2IFY9@201174|Actinobacteria,4E2WJ@85010|Pseudonocardiales	201174|Actinobacteria	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
REGS3_k127_4515107_0	1313172.YM304_27040	2.146e-224	703.0	COG0621@1|root,COG0621@2|Bacteria,2GJEV@201174|Actinobacteria,4CMWG@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
REGS3_k127_4515107_1	402881.Plav_3137	5.22e-219	690.0	COG3119@1|root,COG3119@2|Bacteria,1MWY7@1224|Proteobacteria,2TV04@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
REGS3_k127_4515107_9	754035.Mesau_05210	5.52e-48	173.0	COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2TQP0@28211|Alphaproteobacteria,43HW8@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031,ko:K02032,ko:K10823,ko:K13896,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00349,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.21,3.A.1.5.24,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
REGS3_k127_4520156_5	247634.GPB2148_1673	1.138e-78	275.0	COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,1RMVE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal
REGS3_k127_4520156_2	675635.Psed_1294	8.709e-102	349.0	COG1249@1|root,COG1249@2|Bacteria,2GJJK@201174|Actinobacteria,4E97Z@85010|Pseudonocardiales	201174|Actinobacteria	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim
REGS3_k127_4520156_1	1313172.YM304_17270	1.984e-105	356.0	COG0477@1|root,COG2814@2|Bacteria,2I2IS@201174|Actinobacteria	201174|Actinobacteria	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
REGS3_k127_4520156_0	710685.MycrhN_3880	1.256e-242	766.0	COG0154@1|root,COG0154@2|Bacteria,2GKPZ@201174|Actinobacteria,234NV@1762|Mycobacteriaceae	201174|Actinobacteria	J	Belongs to the amidase family	amiC_1	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
REGS3_k127_4520156_4	1313172.YM304_13840	9.495e-101	332.0	COG1028@1|root,COG1028@2|Bacteria,2GJU1@201174|Actinobacteria	201174|Actinobacteria	IQ	Short-chain dehydrogenase reductase sdr	-	-	1.1.1.69	ko:K00046	-	-	-	-	ko00000,ko01000	-	-	-	adh_short_C2
REGS3_k127_4543943_9	1313172.YM304_17870	4.377e-66	231.0	COG1085@1|root,COG1085@2|Bacteria,2IJIM@201174|Actinobacteria	201174|Actinobacteria	C	Galactose-1-phosphate uridyl transferase, N-terminal domain	-	-	2.7.7.12	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	M00362,M00554,M00632	R00955	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	GalP_UDP_transf
REGS3_k127_4543943_0	1313172.YM304_33870	2.757e-295	923.0	COG3345@1|root,COG3345@2|Bacteria,2GJJ1@201174|Actinobacteria	201174|Actinobacteria	G	alpha-galactosidase	rafA	-	3.2.1.22	ko:K07407	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_36C,Glyco_hydro_36N,Melibiase
REGS3_k127_4543943_14	1313172.YM304_10210	2.326e-18	92.0	2E7DD@1|root,331WH@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_4543943_11	1313172.YM304_33820	1.381e-31	132.0	COG0721@1|root,COG0721@2|Bacteria,2HH3E@201174|Actinobacteria,4CP3G@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	-	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Glu-tRNAGln
REGS3_k127_4543943_1	1313172.YM304_33810	9.783e-217	682.0	COG0154@1|root,COG0154@2|Bacteria,2GJK5@201174|Actinobacteria,4CMQJ@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
REGS3_k127_4543943_2	1313172.YM304_33800	4.34e-212	677.0	COG0064@1|root,COG0064@2|Bacteria,2GJJH@201174|Actinobacteria,4CMV1@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	-	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
REGS3_k127_4543943_12	710686.Mycsm_02453	1.805e-24	106.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	-	ko:K08234	-	-	-	-	ko00000	-	-	-	Glyoxalase
REGS3_k127_4543943_5	745776.DGo_CA0633	7.616e-123	406.0	COG0624@1|root,COG0624@2|Bacteria,1WKXT@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	Peptidase family M28	-	-	3.5.1.6,3.5.1.87	ko:K06016	ko00240,ko01100,map00240,map01100	M00046	R00905,R04666	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	Peptidase_M20
REGS3_k127_4543943_6	1313172.YM304_33850	4.994e-88	304.0	COG4552@1|root,COG4552@2|Bacteria,2GNXZ@201174|Actinobacteria	201174|Actinobacteria	S	N-acetyltransferase	eis	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0008080,GO:0008150,GO:0008152,GO:0009056,GO:0009605,GO:0009607,GO:0009987,GO:0010941,GO:0016137,GO:0016139,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016999,GO:0017001,GO:0017144,GO:0030647,GO:0030649,GO:0031347,GO:0031349,GO:0032101,GO:0032103,GO:0034069,GO:0035821,GO:0040007,GO:0042802,GO:0043067,GO:0043207,GO:0044003,GO:0044068,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044121,GO:0044237,GO:0044248,GO:0044403,GO:0044419,GO:0044531,GO:0048518,GO:0048583,GO:0048584,GO:0050727,GO:0050729,GO:0050789,GO:0050794,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052032,GO:0052035,GO:0052040,GO:0052164,GO:0052167,GO:0052173,GO:0052200,GO:0052248,GO:0052255,GO:0052256,GO:0052259,GO:0052303,GO:0052306,GO:0052509,GO:0052510,GO:0052550,GO:0052552,GO:0052553,GO:0052564,GO:0052567,GO:0052572,GO:0065007,GO:0071704,GO:0075136,GO:0080134,GO:1901135,GO:1901136,GO:1901575,GO:1901657,GO:1901658	-	-	-	-	-	-	-	-	-	-	Acetyltransf_9,SCP2_2
REGS3_k127_4543943_4	1229780.BN381_60006	2.964e-166	533.0	COG0427@1|root,COG0427@2|Bacteria,2IAMG@201174|Actinobacteria,3UXF8@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	Acetyl-CoA hydrolase/transferase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AcetylCoA_hyd_C
REGS3_k127_4543943_7	378806.STAUR_0036	2.672e-80	283.0	COG0477@1|root,COG0477@2|Bacteria,1MXZ3@1224|Proteobacteria,43BMH@68525|delta/epsilon subdivisions	1224|Proteobacteria	EGP	Major facilitator superfamily	MA20_25180	-	-	-	-	-	-	-	-	-	-	-	MFS_3
REGS3_k127_4543943_10	1122604.JONR01000001_gene1714	1.15e-64	234.0	COG4221@1|root,COG4221@2|Bacteria,1R83E@1224|Proteobacteria,1RX38@1236|Gammaproteobacteria,1XAGX@135614|Xanthomonadales	135614|Xanthomonadales	S	NAD dependent epimerase/dehydratase family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
REGS3_k127_4543943_8	1323361.JPOC01000021_gene2722	1.264e-71	254.0	COG3324@1|root,COG3324@2|Bacteria,2GJFC@201174|Actinobacteria,4FV36@85025|Nocardiaceae	201174|Actinobacteria	S	glyoxalase bleomycin resistance protein dioxygenase	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K06996	-	-	-	-	ko00000	-	-	-	Glyoxalase
REGS3_k127_4543943_3	350058.Mvan_1892	2.238e-194	613.0	COG1960@1|root,COG1960@2|Bacteria,2GJX5@201174|Actinobacteria,2357V@1762|Mycobacteriaceae	201174|Actinobacteria	I	acyl-CoA dehydrogenase	fadE12_3	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
REGS3_k127_4543943_13	1300350.DSW25_02095	2.015e-21	98.0	COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,2TRBN@28211|Alphaproteobacteria,3ZWAC@60136|Sulfitobacter	28211|Alphaproteobacteria	EQ	Hydantoinase/oxoprolinase N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	Hydant_A_N,Hydantoinase_A
REGS3_k127_4589674_1	471852.Tcur_1339	9.242e-69	238.0	COG1505@1|root,COG1505@2|Bacteria,2IRXB@201174|Actinobacteria,4EG49@85012|Streptosporangiales	201174|Actinobacteria	E	Prolyl oligopeptidase, N-terminal beta-propeller domain	-	-	3.4.21.26	ko:K01322	ko04614,map04614	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
REGS3_k127_4589674_2	1313172.YM304_32920	3.018e-47	181.0	COG3324@1|root,COG3324@2|Bacteria,2I6WX@201174|Actinobacteria	201174|Actinobacteria	E	translation initiation factor activity	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_4589674_5	1283287.KB822578_gene2482	5.132e-11	72.0	COG1376@1|root,COG1376@2|Bacteria,2IIU7@201174|Actinobacteria,4DRAD@85009|Propionibacteriales	201174|Actinobacteria	S	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
REGS3_k127_4589674_0	1313172.YM304_32840	4.341e-114	377.0	COG1468@1|root,COG1468@2|Bacteria,2HE3R@201174|Actinobacteria,4CP30@84992|Acidimicrobiia	84992|Acidimicrobiia	L	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_1
REGS3_k127_4589674_3	1313172.YM304_32820	1.169e-29	126.0	2CK2C@1|root,2ZY21@2|Bacteria,2HE72@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_4589674_4	1254432.SCE1572_05745	1.217e-11	76.0	2E4Q1@1|root,32ZIN@2|Bacteria,1R6IY@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_4612081_0	1163409.UUA_15278	3.455e-132	436.0	COG1032@1|root,COG1032@2|Bacteria,1RCWX@1224|Proteobacteria,1SYF2@1236|Gammaproteobacteria,1X5WI@135614|Xanthomonadales	135614|Xanthomonadales	C	Mg-protoporphyrin IX monomethyl ester oxidative cyclase	-	-	1.21.98.3	ko:K04034	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R06268,R06269,R06270	RC00741,RC01491,RC01492	ko00000,ko00001,ko01000	-	-	-	B12-binding,Radical_SAM
REGS3_k127_4612081_2	666685.R2APBS1_0667	9.247e-85	290.0	COG0500@1|root,COG2226@2|Bacteria,1R8N9@1224|Proteobacteria,1SYVC@1236|Gammaproteobacteria,1X2Z5@135614|Xanthomonadales	135614|Xanthomonadales	Q	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
REGS3_k127_4612081_4	1229780.BN381_50019	2.922e-69	258.0	COG1132@1|root,COG1132@2|Bacteria,2HXAQ@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter ATP-binding	-	-	-	-	-	-	-	-	-	-	-	-	ABC_membrane,ABC_tran
REGS3_k127_4612081_11	1040983.AXAE01000027_gene5178	7.716e-22	113.0	COG3468@1|root,COG3468@2|Bacteria,1QUZ3@1224|Proteobacteria,2U1BI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	MU	Autotransporter beta-domain	-	-	-	-	-	-	-	-	-	-	-	-	Autotransporter,TIG
REGS3_k127_4612081_10	1229780.BN381_40068	2.941e-28	123.0	2CCAB@1|root,346WD@2|Bacteria,2H96I@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_4612081_1	469383.Cwoe_3132	7.468e-106	374.0	COG3210@1|root,COG4932@1|root,COG3210@2|Bacteria,COG4932@2|Bacteria,2GJ4T@201174|Actinobacteria,4CRS5@84995|Rubrobacteria	84995|Rubrobacteria	MU	Protein of unknown function (DUF3494)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3494
REGS3_k127_4612081_7	1123073.KB899245_gene23	1.036e-61	240.0	COG3291@1|root,COG4102@1|root,COG3291@2|Bacteria,COG4102@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	CHAP,Cleaved_Adhesin,Reprolysin_4
REGS3_k127_4612081_5	1121877.JQKF01000012_gene331	1.909e-68	240.0	28KBH@1|root,2Z9YH@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_4612081_3	1121877.JQKF01000012_gene330	7.169e-82	283.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
REGS3_k127_4612081_6	525909.Afer_1161	8.966e-68	248.0	COG0644@1|root,COG0644@2|Bacteria,2GMH9@201174|Actinobacteria,4CNQ0@84992|Acidimicrobiia	84992|Acidimicrobiia	C	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
REGS3_k127_4612081_8	931626.Awo_c20220	7.188e-55	199.0	COG0727@1|root,COG0727@2|Bacteria	2|Bacteria	S	metal cluster binding	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
REGS3_k127_4612081_15	446462.Amir_2391	4.363e-14	77.0	2DZG8@1|root,33KNR@2|Bacteria,2HNSX@201174|Actinobacteria,4E78Z@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_4612081_12	105420.BBPO01000021_gene5677	3.214e-19	96.0	COG3450@1|root,COG3450@2|Bacteria,2ISIX@201174|Actinobacteria,2NJB4@228398|Streptacidiphilus	201174|Actinobacteria	S	Protein of unknown function (DUF861)	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_3
REGS3_k127_4612081_14	1192868.CAIU01000013_gene1685	2.066e-16	87.0	COG3450@1|root,COG3450@2|Bacteria,1Q524@1224|Proteobacteria,2VBG5@28211|Alphaproteobacteria,43PE1@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF861)	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_3
REGS3_k127_4612081_9	1150399.AQYK01000001_gene1450	3.713e-48	181.0	COG0725@1|root,COG0725@2|Bacteria,2GMPF@201174|Actinobacteria,4FNG8@85023|Microbacteriaceae	201174|Actinobacteria	P	Bacterial extracellular solute-binding protein	modA	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0008150,GO:0030288,GO:0030313,GO:0030973,GO:0031975,GO:0040007,GO:0042597,GO:0043167,GO:0043168,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0051704	-	ko:K02020	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	SBP_bac_11
REGS3_k127_4613680_10	675635.Psed_0588	3.844e-34	133.0	COG1396@1|root,COG1396@2|Bacteria,2IKVI@201174|Actinobacteria,4E4CI@85010|Pseudonocardiales	201174|Actinobacteria	K	PFAM Helix-turn-helix	-	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	HTH_3,HTH_31
REGS3_k127_4613680_0	1313172.YM304_37900	1.353e-166	532.0	COG0297@1|root,COG0438@1|root,COG0297@2|Bacteria,COG0438@2|Bacteria,2GJ57@201174|Actinobacteria,4CMYV@84992|Acidimicrobiia	84992|Acidimicrobiia	M	Glycosyl transferase 4-like domain	-	-	2.4.1.250	ko:K15521	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_transf_4,Glycos_transf_1
REGS3_k127_4613680_9	1313172.YM304_37890	5.6e-56	199.0	2AZ39@1|root,31R9K@2|Bacteria,2GMCY@201174|Actinobacteria	201174|Actinobacteria	S	Putative bacterial sensory transduction regulator	-	-	-	-	-	-	-	-	-	-	-	-	YbjN
REGS3_k127_4613680_7	222534.KB893765_gene2930	2.559e-78	278.0	COG0451@1|root,COG0451@2|Bacteria	2|Bacteria	GM	ADP-glyceromanno-heptose 6-epimerase activity	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
REGS3_k127_4613680_1	1123320.KB889662_gene1680	5.845e-158	509.0	COG1804@1|root,COG1804@2|Bacteria,2GIU7@201174|Actinobacteria	201174|Actinobacteria	C	L-carnitine dehydratase bile acid-inducible protein F	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
REGS3_k127_4613680_8	1229780.BN381_60047	2.321e-71	250.0	COG0345@1|root,COG0345@2|Bacteria,2GJ7D@201174|Actinobacteria,3UWS1@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	GO:0000287,GO:0003674,GO:0003824,GO:0004735,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0018130,GO:0019752,GO:0030145,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0046914,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_oxidored,P5CR_dimer
REGS3_k127_4613680_3	1313172.YM304_37870	7.354e-108	357.0	COG1912@1|root,COG1912@2|Bacteria,2IASJ@201174|Actinobacteria	201174|Actinobacteria	S	transferase activity, transferring alkyl or aryl (other than methyl) groups	-	-	-	ko:K22205	-	-	-	-	ko00000,ko01000	-	-	-	SAM_adeno_trans
REGS3_k127_4613680_4	1313172.YM304_31060	2.941e-102	363.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria	201174|Actinobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
REGS3_k127_4613680_12	479432.Sros_0545	1.703e-05	56.0	COG1359@1|root,COG1359@2|Bacteria,2HINW@201174|Actinobacteria,4EI7M@85012|Streptosporangiales	201174|Actinobacteria	S	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity	-	-	-	-	-	-	-	-	-	-	-	-	ABM
REGS3_k127_4613680_5	1313172.YM304_37860	2.055e-101	334.0	COG2344@1|root,COG2344@2|Bacteria,2GMV2@201174|Actinobacteria	201174|Actinobacteria	K	Modulates transcription in response to changes in cellular NADH NAD( ) redox state	rex	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K01926	-	-	-	-	ko00000,ko03000	-	-	-	CoA_binding,Put_DNA-bind_N
REGS3_k127_4613680_2	1313172.YM304_37850	4.124e-151	488.0	COG0373@1|root,COG0373@2|Bacteria,2GJRA@201174|Actinobacteria,4CN61@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	-	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
REGS3_k127_4613680_6	1313172.YM304_37840	2.864e-89	302.0	COG0181@1|root,COG0181@2|Bacteria,2GMWI@201174|Actinobacteria,4CN1F@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	-	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	-	Porphobil_deam,Porphobil_deamC
REGS3_k127_4613680_11	234267.Acid_3181	8.126e-12	69.0	COG0007@1|root,COG1587@1|root,COG0007@2|Bacteria,COG1587@2|Bacteria,3Y4W1@57723|Acidobacteria	57723|Acidobacteria	H	synthase	-	-	2.1.1.107,4.2.1.75	ko:K01719,ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165,R03194	RC00003,RC00871,RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4,TP_methylase
REGS3_k127_4638472_18	1449976.KALB_3986	2.405e-50	183.0	COG0402@1|root,COG0402@2|Bacteria,2GKKM@201174|Actinobacteria,4DXWF@85010|Pseudonocardiales	201174|Actinobacteria	F	Amidohydrolase family	-	-	3.5.4.1	ko:K01485	ko00240,ko00330,ko01100,map00240,map00330,map01100	-	R00974,R01411,R02922	RC00074,RC00514,RC00809	ko00000,ko00001,ko01000	-	-	-	Amidohydro_3
REGS3_k127_4638472_11	477641.MODMU_1500	1.507e-83	284.0	COG1028@1|root,COG1028@2|Bacteria,2IJEQ@201174|Actinobacteria	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
REGS3_k127_4638472_7	1283299.AUKG01000004_gene1016	9.45e-108	355.0	COG1116@1|root,COG1116@2|Bacteria,2GN33@201174|Actinobacteria,4CRRY@84995|Rubrobacteria	84995|Rubrobacteria	P	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
REGS3_k127_4638472_14	1160137.KB907307_gene3170	1.395e-68	251.0	COG0600@1|root,COG0600@2|Bacteria,2IBTW@201174|Actinobacteria,4FYI1@85025|Nocardiaceae	201174|Actinobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
REGS3_k127_4638472_8	1043493.BBLU01000007_gene19	6.801e-103	351.0	COG0715@1|root,COG0715@2|Bacteria,2I95I@201174|Actinobacteria	201174|Actinobacteria	P	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_4638472_2	1313172.YM304_01600	2.344e-156	505.0	COG0624@1|root,COG0624@2|Bacteria,2GJDE@201174|Actinobacteria,4CN6K@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Peptidase family M28	-	-	3.5.1.6,3.5.1.87	ko:K06016	ko00240,ko01100,map00240,map01100	M00046	R00905,R04666	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
REGS3_k127_4638472_5	1313172.YM304_25380	1.804e-120	391.0	COG1402@1|root,COG1402@2|Bacteria,2HCRK@201174|Actinobacteria	201174|Actinobacteria	S	Creatininase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
REGS3_k127_4638472_1	1313172.YM304_25370	1.106e-203	646.0	COG1233@1|root,COG1233@2|Bacteria,2IE6C@201174|Actinobacteria	201174|Actinobacteria	Q	FAD dependent oxidoreductase	crtO	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
REGS3_k127_4638472_9	1313172.YM304_25350	1.213e-84	283.0	COG2236@1|root,COG2236@2|Bacteria,2GN86@201174|Actinobacteria	201174|Actinobacteria	F	phosphoribosyltransferase	gpt	-	-	ko:K07101	-	-	-	-	ko00000	-	-	-	Pribosyltran
REGS3_k127_4638472_0	1313172.YM304_25340	0.0	1132.0	COG1529@1|root,COG1529@2|Bacteria,2GIVI@201174|Actinobacteria	201174|Actinobacteria	C	aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	pucD	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
REGS3_k127_4638472_12	1313172.YM304_25330	3.893e-75	255.0	COG2080@1|root,COG2080@2|Bacteria,2GMXT@201174|Actinobacteria	201174|Actinobacteria	C	[2Fe-2S] binding domain	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
REGS3_k127_4638472_6	1313172.YM304_25320	6.797e-108	356.0	COG4630@1|root,COG4630@2|Bacteria,2I33J@201174|Actinobacteria	201174|Actinobacteria	F	Xanthine dehydrogenase iron-sulfur cluster and FAD-binding subunit A	xdhA	-	1.17.1.4	ko:K13481	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5,Fer2,Fer2_2
REGS3_k127_4638472_10	1122221.JHVI01000013_gene2784	1.302e-84	292.0	COG2326@1|root,COG2326@2|Bacteria,1WKEJ@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	PFAM Polyphosphate kinase 2 (PPK2)	-	-	2.7.4.1	ko:K22468	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PPK2
REGS3_k127_4638472_19	1313172.YM304_25300	6.552e-20	94.0	29QVV@1|root,30BW4@2|Bacteria,2GVRY@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_4638472_15	1229780.BN381_20131	1.048e-67	253.0	COG0747@1|root,COG0747@2|Bacteria,2GJ4B@201174|Actinobacteria,3UXHK@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	E	Evidence 5 No homology to any previously reported sequences	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
REGS3_k127_4638472_17	2055.JNXA01000006_gene773	7.417e-51	192.0	COG0601@1|root,COG0601@2|Bacteria,2GK0Z@201174|Actinobacteria,4GD4X@85026|Gordoniaceae	201174|Actinobacteria	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
REGS3_k127_4638472_16	1229780.BN381_20134	2.549e-51	193.0	COG1173@1|root,COG1173@2|Bacteria,2GJ9E@201174|Actinobacteria,3UWXI@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	P	COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
REGS3_k127_4638472_3	1120936.KB907209_gene1792	4.87e-142	458.0	COG0444@1|root,COG0444@2|Bacteria,2GIXV@201174|Actinobacteria	201174|Actinobacteria	EP	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031,ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,BPD_transp_1,oligo_HPY
REGS3_k127_4638472_4	1146883.BLASA_2833	1.221e-138	454.0	COG4608@1|root,COG4608@2|Bacteria,2H4BW@201174|Actinobacteria,4EUCP@85013|Frankiales	201174|Actinobacteria	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
REGS3_k127_4638472_13	1206731.BAGB01000167_gene898	1.37e-68	238.0	COG1024@1|root,COG1024@2|Bacteria,2GJ7Z@201174|Actinobacteria,4G0ZS@85025|Nocardiaceae	201174|Actinobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
REGS3_k127_4727819_6	1343740.M271_05020	6.001e-110	369.0	COG0446@1|root,COG0446@2|Bacteria,2GKQN@201174|Actinobacteria	201174|Actinobacteria	S	pyridine nucleotide-disulfide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2
REGS3_k127_4727819_4	653045.Strvi_4072	8.445e-150	493.0	COG0579@1|root,COG0579@2|Bacteria,2GKFB@201174|Actinobacteria	201174|Actinobacteria	S	FAD dependent oxidoreductase	-	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,Fer2_BFD
REGS3_k127_4727819_3	1380347.JNII01000005_gene3048	8.154e-153	496.0	COG0554@1|root,COG0554@2|Bacteria,2GM13@201174|Actinobacteria,4EREP@85013|Frankiales	201174|Actinobacteria	C	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	-	-	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
REGS3_k127_4727819_5	1313172.YM304_23970	2.206e-135	440.0	COG0318@1|root,COG0318@2|Bacteria,2GN9C@201174|Actinobacteria,4CN14@84992|Acidimicrobiia	84992|Acidimicrobiia	IQ	AMP-binding enzyme C-terminal domain	-	-	6.2.1.26	ko:K01911	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R04030	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	AMP-binding,AMP-binding_C
REGS3_k127_4727819_2	1313172.YM304_06890	1.833e-154	502.0	COG0154@1|root,COG0154@2|Bacteria,2GKPZ@201174|Actinobacteria	201174|Actinobacteria	J	Belongs to the amidase family	bam	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
REGS3_k127_4727819_7	1313172.YM304_23980	6.51e-109	362.0	COG1575@1|root,COG1575@2|Bacteria,2GJBS@201174|Actinobacteria,4CN0D@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Belongs to the MenA family. Type 1 subfamily	menA	-	2.5.1.74	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R05617,R06858,R10757	RC02935,RC02936,RC03264	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
REGS3_k127_4727819_10	1192034.CAP_1582	7.643e-62	227.0	COG2267@1|root,COG2267@2|Bacteria,1QUFU@1224|Proteobacteria,43BQ1@68525|delta/epsilon subdivisions,2X718@28221|Deltaproteobacteria,2Z3MK@29|Myxococcales	28221|Deltaproteobacteria	I	alpha/beta hydrolase fold	menH	-	4.2.99.20	ko:K08680	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R08166	RC02148,RC02475	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_6
REGS3_k127_4727819_9	1313172.YM304_24000	3.099e-65	237.0	COG2761@1|root,COG2761@2|Bacteria,2GNBC@201174|Actinobacteria	201174|Actinobacteria	Q	Dithiol-disulfide isomerase involved in polyketide biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	DSBA
REGS3_k127_4727819_1	1313172.YM304_24010	1.661e-155	510.0	COG1165@1|root,COG1165@2|Bacteria,2GMEB@201174|Actinobacteria,4CN69@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)	menD	-	2.2.1.9	ko:K02551	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R08165	RC02186	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_N
REGS3_k127_4727819_0	1313172.YM304_24020	3.188e-157	504.0	COG1169@1|root,COG1169@2|Bacteria,2GKE8@201174|Actinobacteria,4CNAM@84992|Acidimicrobiia	84992|Acidimicrobiia	HQ	chorismate binding enzyme	-	-	5.4.4.2	ko:K02552	ko00130,ko01053,ko01100,ko01110,ko01130,map00130,map01053,map01100,map01110,map01130	M00116	R01717	RC00588	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_bind
REGS3_k127_4727819_8	1313172.YM304_24030	2.556e-94	312.0	COG0500@1|root,COG2226@2|Bacteria,2GKFZ@201174|Actinobacteria,4CN6D@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)	menG	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
REGS3_k127_4776399_10	469371.Tbis_0680	4.317e-09	61.0	COG1079@1|root,COG1079@2|Bacteria,2GKMB@201174|Actinobacteria,4E0NX@85010|Pseudonocardiales	201174|Actinobacteria	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
REGS3_k127_4776399_5	2002.JOEQ01000010_gene6227	3.823e-77	276.0	COG4603@1|root,COG4603@2|Bacteria,2GKAZ@201174|Actinobacteria,4EGW6@85012|Streptosporangiales	201174|Actinobacteria	S	Branched-chain amino acid transport system / permease component	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
REGS3_k127_4776399_0	1229780.BN381_20088	3.869e-186	595.0	COG3845@1|root,COG3845@2|Bacteria,2H7KJ@201174|Actinobacteria,3UWDV@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	ATPases associated with a variety of cellular activities	yufO	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
REGS3_k127_4776399_3	1133850.SHJG_6004	3.876e-90	308.0	COG1744@1|root,COG1744@2|Bacteria,2GMFS@201174|Actinobacteria	201174|Actinobacteria	S	basic membrane	-	-	-	ko:K07335	-	-	-	-	ko00000	-	-	-	Bmp
REGS3_k127_4776399_6	1313172.YM304_11230	3.059e-64	232.0	COG2845@1|root,COG2845@2|Bacteria,2GU62@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF459)	-	-	-	ko:K09795	-	-	-	-	ko00000	-	-	-	DUF459
REGS3_k127_4776399_1	1313172.YM304_11240	3.336e-118	385.0	COG1024@1|root,COG1024@2|Bacteria,2GJ0N@201174|Actinobacteria,4CNYM@84992|Acidimicrobiia	201174|Actinobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.17,4.2.1.18	ko:K01692,ko:K13766	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00036,M00087	R02085,R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115,RC02416	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
REGS3_k127_4776399_4	1313172.YM304_11280	1.208e-89	299.0	2C2IJ@1|root,33VBE@2|Bacteria,2H4HS@201174|Actinobacteria,4CN8V@84992|Acidimicrobiia	84992|Acidimicrobiia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_4776399_8	1150599.MPHLEI_12996	1.588e-38	153.0	COG1051@1|root,COG1051@2|Bacteria,2IK26@201174|Actinobacteria,23DC5@1762|Mycobacteriaceae	201174|Actinobacteria	F	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
REGS3_k127_4776399_2	1313172.YM304_33510	1.163e-112	372.0	COG1024@1|root,COG1024@2|Bacteria,2H2G7@201174|Actinobacteria	201174|Actinobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	echA14	GO:0003674,GO:0003824,GO:0004300,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
REGS3_k127_4776399_7	1313172.YM304_33450	9.27e-40	149.0	COG1670@1|root,COG1670@2|Bacteria,2HFKU@201174|Actinobacteria,4CP4F@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Acetyltransferase (GNAT) domain	-	-	2.3.1.128	ko:K03790	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_3
REGS3_k127_4792341_7	1229780.BN381_10324	5.712e-75	269.0	COG0153@1|root,COG0153@2|Bacteria,2GJXI@201174|Actinobacteria,3UWRM@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	G	Belongs to the GHMP kinase family	galK	-	2.7.1.6	ko:K00849	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00554,M00632	R01092	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg
REGS3_k127_4792341_6	653045.Strvi_4628	1.793e-83	287.0	COG2141@1|root,COG2141@2|Bacteria,2GJ6T@201174|Actinobacteria	201174|Actinobacteria	C	F420-dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
REGS3_k127_4792341_2	1313172.YM304_23380	5.681e-183	579.0	COG1804@1|root,COG1804@2|Bacteria,2GKNX@201174|Actinobacteria,4CMVD@84992|Acidimicrobiia	84992|Acidimicrobiia	C	CoA-transferase family III	-	-	5.1.99.4	ko:K01796	ko00120,ko01100,ko04146,map00120,map01100,map04146	M00104	R08734,R08739	RC02345	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_transf_3
REGS3_k127_4792341_4	1313172.YM304_23390	5.94e-107	353.0	COG2120@1|root,COG2120@2|Bacteria,2GIUS@201174|Actinobacteria	201174|Actinobacteria	S	PFAM LmbE family protein	rifO	-	-	-	-	-	-	-	-	-	-	-	PIG-L
REGS3_k127_4792341_8	1333998.M2A_1085	2.977e-44	168.0	COG0406@1|root,COG0406@2|Bacteria,1MYD7@1224|Proteobacteria,2TVST@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Phosphoglycerate mutase family	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
REGS3_k127_4792341_5	1313172.YM304_03860	1.989e-99	332.0	COG2833@1|root,COG2833@2|Bacteria	2|Bacteria	I	Protein of unknown function (DUF455)	-	-	2.7.1.165	ko:K11529	ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200	M00346	R08572	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF455
REGS3_k127_4792341_12	1229780.BN381_10335	9.939e-13	70.0	291CY@1|root,2ZNZT@2|Bacteria,2HDEE@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_4792341_13	1229780.BN381_10335	4.873e-09	57.0	291CY@1|root,2ZNZT@2|Bacteria,2HDEE@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_4792341_0	1313172.YM304_18480	0.0	1032.0	COG1274@1|root,COG1274@2|Bacteria,2GJH3@201174|Actinobacteria,4CMPT@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle	pckG	-	4.1.1.32	ko:K01596	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964	M00003	R00431,R00726	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_C,PEPCK_N
REGS3_k127_4792341_9	1313172.YM304_18490	4.207e-30	125.0	COG1278@1|root,COG1278@2|Bacteria,2HC2C@201174|Actinobacteria	201174|Actinobacteria	K	Cold shock	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	-
REGS3_k127_4792341_10	1313172.YM304_18500	1.822e-29	118.0	COG0227@1|root,COG0227@2|Bacteria,2HH3N@201174|Actinobacteria,4CP3S@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Ribosomal L28 family	rpmB	-	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
REGS3_k127_4792341_1	1313172.YM304_18510	1.31e-227	719.0	COG1461@1|root,COG1461@2|Bacteria,2GKII@201174|Actinobacteria,4CMTA@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Dak1_2	-	-	-	ko:K07030	-	-	-	-	ko00000	-	-	-	Dak1_2,Dak2
REGS3_k127_4792341_3	1313172.YM304_18530	3.521e-143	460.0	COG1200@1|root,COG1200@2|Bacteria,2GKA3@201174|Actinobacteria,4CMPC@84992|Acidimicrobiia	84992|Acidimicrobiia	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
REGS3_k127_4815393_4	1313172.YM304_18400	3.542e-51	188.0	COG0772@1|root,COG0772@2|Bacteria,2GK2G@201174|Actinobacteria,4CN2U@84992|Acidimicrobiia	84992|Acidimicrobiia	D	Cell cycle protein	-	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
REGS3_k127_4815393_0	1313172.YM304_18390	2.201e-244	775.0	COG0768@1|root,COG0768@2|Bacteria,2GJ61@201174|Actinobacteria,4CMYJ@84992|Acidimicrobiia	84992|Acidimicrobiia	M	Penicillin-binding Protein dimerisation domain	-	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
REGS3_k127_4815393_6	1313172.YM304_18380	2.728e-38	149.0	2EQHK@1|root,33I3K@2|Bacteria,2HGHC@201174|Actinobacteria,4CNEQ@84992|Acidimicrobiia	84992|Acidimicrobiia	-	-	-	-	-	ko:K03571	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreD
REGS3_k127_4815393_3	1313172.YM304_18370	4.593e-61	227.0	COG1792@1|root,COG1792@2|Bacteria,2HGG4@201174|Actinobacteria,4CNDF@84992|Acidimicrobiia	84992|Acidimicrobiia	M	Involved in formation and maintenance of cell shape	mreC	-	-	ko:K03570	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreC
REGS3_k127_4815393_1	1313172.YM304_18360	2.57e-199	626.0	COG1077@1|root,COG1077@2|Bacteria,2GMD1@201174|Actinobacteria,4CMUQ@84992|Acidimicrobiia	84992|Acidimicrobiia	D	Cell division protein FtsA	-	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
REGS3_k127_4815393_2	1313172.YM304_18350	4.621e-72	244.0	COG0105@1|root,COG0105@2|Bacteria,2IFBU@201174|Actinobacteria,4CN6F@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	-	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
REGS3_k127_4815393_5	1313172.YM304_18330	2.113e-48	176.0	COG0285@1|root,COG0285@2|Bacteria,2GJP2@201174|Actinobacteria,4CNAR@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Mur ligase middle domain	-	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_M
REGS3_k127_4824627_1	1313172.YM304_22550	3.28e-124	406.0	COG3173@1|root,COG3173@2|Bacteria,2HU7E@201174|Actinobacteria	201174|Actinobacteria	S	Aminoglycoside phosphotransferase	-	-	-	-	-	-	-	-	-	-	-	-	APH
REGS3_k127_4824627_6	1313172.YM304_22540	8.751e-63	231.0	COG0739@1|root,COG0739@2|Bacteria	2|Bacteria	M	heme binding	lytH	-	-	ko:K06401,ko:K21472	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	DUF3289,Peptidase_M23,SH3_3
REGS3_k127_4824627_3	1313172.YM304_22530	1.405e-92	311.0	COG1119@1|root,COG1119@2|Bacteria,2GIXX@201174|Actinobacteria,4CN5B@84992|Acidimicrobiia	84992|Acidimicrobiia	P	ATPases associated with a variety of cellular activities	-	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
REGS3_k127_4824627_13	1229780.BN381_290139	5.482e-23	104.0	2FJAX@1|root,34B0V@2|Bacteria,2H7B1@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_4824627_9	479435.Kfla_3167	3.205e-40	155.0	COG1576@1|root,COG1576@2|Bacteria,2I3MI@201174|Actinobacteria,4DQMN@85009|Propionibacteriales	201174|Actinobacteria	J	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1,MDMPI_N
REGS3_k127_4824627_0	557599.MKAN_04505	2.08e-322	1010.0	COG0474@1|root,COG0474@2|Bacteria,2GJJC@201174|Actinobacteria,2378B@1762|Mycobacteriaceae	201174|Actinobacteria	P	possibly catalyzes the transport of a undeterminated metal cation with the hydrolyse of ATP catalytic activity ATP H(2)O undeterminated metal cation(in) ADP phosphate undeterminated metal cation(out)	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
REGS3_k127_4824627_4	1048339.KB913029_gene2070	8.315e-81	282.0	COG3173@1|root,COG3173@2|Bacteria,2GNNV@201174|Actinobacteria,4EW64@85013|Frankiales	201174|Actinobacteria	S	PFAM aminoglycoside phosphotransferase	-	-	2.7.1.72	ko:K04343	-	M00766	R02225	RC00002,RC00078	br01600,ko00000,ko00002,ko01000,ko01504	-	-	-	APH
REGS3_k127_4824627_11	1313172.YM304_22460	5.755e-32	132.0	COG0484@1|root,COG0484@2|Bacteria,2HAB8@201174|Actinobacteria,4CP1J@84992|Acidimicrobiia	84992|Acidimicrobiia	O	DnaJ molecular chaperone homology domain	-	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ
REGS3_k127_4824627_2	321332.CYB_1677	3.02e-93	315.0	COG0111@1|root,COG0111@2|Bacteria,1G417@1117|Cyanobacteria,1H2J2@1129|Synechococcus	1117|Cyanobacteria	EH	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh,2-Hacid_dh_C
REGS3_k127_4824627_7	1173264.KI913949_gene4108	1.69e-54	208.0	COG1231@1|root,COG1231@2|Bacteria,1G3YC@1117|Cyanobacteria,1HCPQ@1150|Oscillatoriales	1117|Cyanobacteria	E	Flavin containing amine oxidoreductase	-	-	1.4.3.4	ko:K00274	ko00260,ko00330,ko00340,ko00350,ko00360,ko00380,ko00950,ko00982,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00260,map00330,map00340,map00350,map00360,map00380,map00950,map00982,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00135	R02173,R02382,R02529,R02532,R02613,R02908,R02919,R04025,R04300,R04674,R04890,R04893,R04894,R04907,R04908,R08346,R08347,R08348,R11354	RC00062,RC00160,RC00225,RC00676,RC00807,RC00808,RC01808,RC02226,RC02713	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
REGS3_k127_4824627_5	408672.NBCG_01957	7.177e-64	235.0	COG1177@1|root,COG1177@2|Bacteria,2GJ6Q@201174|Actinobacteria,4DPG3@85009|Propionibacteriales	201174|Actinobacteria	E	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K11070,ko:K11074	ko02010,map02010	M00299,M00300	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1,3.A.1.11.2	-	-	BPD_transp_1
REGS3_k127_4824627_8	1122239.AULS01000006_gene149	3.873e-41	157.0	COG1176@1|root,COG1176@2|Bacteria,2GJ5G@201174|Actinobacteria,4FKXK@85023|Microbacteriaceae	201174|Actinobacteria	E	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K11071	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	BPD_transp_1
REGS3_k127_4835574_3	1333998.M2A_1851	1.896e-22	98.0	COG2141@1|root,COG2141@2|Bacteria,1MX64@1224|Proteobacteria,2TV8M@28211|Alphaproteobacteria,4BTBG@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
REGS3_k127_4835574_1	1380355.JNIJ01000009_gene1754	1.601e-64	233.0	COG4221@1|root,COG4221@2|Bacteria,1MVYG@1224|Proteobacteria,2TSTP@28211|Alphaproteobacteria,3JU6V@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
REGS3_k127_4835574_2	1224136.AMFN01000002_gene695	5.22e-51	194.0	COG0500@1|root,COG2226@2|Bacteria,1MXDY@1224|Proteobacteria,1RMU7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	Methyl-transferase	rrmA	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005488,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008270,GO:0008649,GO:0008757,GO:0008989,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0046872,GO:0046914,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.187	ko:K00563	-	-	R07233	RC00003	ko00000,ko01000,ko03009	-	-	-	Methyltransf_11,Methyltransf_25,Methyltransf_31
REGS3_k127_4835574_5	1157640.AQWO01000008_gene3988	2.757e-09	70.0	COG3409@1|root,COG3409@2|Bacteria,2I9HW@201174|Actinobacteria	201174|Actinobacteria	M	Putative peptidoglycan binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_3,PG_binding_1
REGS3_k127_4835574_4	485918.Cpin_5094	5.187e-20	106.0	COG1472@1|root,COG3391@1|root,COG4932@1|root,COG1472@2|Bacteria,COG3391@2|Bacteria,COG4932@2|Bacteria,4PN87@976|Bacteroidetes	976|Bacteroidetes	M	Calx-beta domain	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,Calx-beta,DUF11
REGS3_k127_4835574_6	643648.Slip_1529	7.705e-05	56.0	COG0845@1|root,COG0845@2|Bacteria,1UUEP@1239|Firmicutes,24CTR@186801|Clostridia,42KPM@68298|Syntrophomonadaceae	186801|Clostridia	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
REGS3_k127_4835574_0	1209989.TepiRe1_1609	2.999e-67	241.0	COG1136@1|root,COG1136@2|Bacteria,1TPBJ@1239|Firmicutes,248EZ@186801|Clostridia,42G06@68295|Thermoanaerobacterales	186801|Clostridia	P	Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
REGS3_k127_4856007_5	1445613.JALM01000076_gene185	9.16e-17	83.0	COG0346@1|root,COG0346@2|Bacteria,2IHU2@201174|Actinobacteria,4E3VG@85010|Pseudonocardiales	201174|Actinobacteria	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_4856007_3	105420.BBPO01000125_gene4703	1.459e-34	147.0	29BBV@1|root,2ZCHD@2|Bacteria,2I82W@201174|Actinobacteria,2NNJY@228398|Streptacidiphilus	201174|Actinobacteria	S	Phosphodiester glycosidase	-	-	-	-	-	-	-	-	-	-	-	-	NAGPA
REGS3_k127_4856007_0	105425.BBPL01000017_gene2326	1.361e-142	458.0	COG1131@1|root,COG1131@2|Bacteria,2GJDP@201174|Actinobacteria,2NGW3@228398|Streptacidiphilus	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
REGS3_k127_4856007_1	1380346.JNIH01000008_gene1340	2.208e-79	274.0	COG1277@1|root,COG1277@2|Bacteria,2GJ2R@201174|Actinobacteria	201174|Actinobacteria	CP	transmembrane transport	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_4
REGS3_k127_4856007_4	1463887.KL590036_gene3621	1.647e-32	134.0	2E39M@1|root,32Y96@2|Bacteria,2IITE@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_4856007_2	1386089.N865_15645	6.186e-60	219.0	COG3291@1|root,COG3291@2|Bacteria,2H2KA@201174|Actinobacteria,4FIPX@85021|Intrasporangiaceae	201174|Actinobacteria	S	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_4912680_14	446468.Ndas_4111	2.062e-45	165.0	COG3383@1|root,COG3383@2|Bacteria,2HC9H@201174|Actinobacteria,4EGXK@85012|Streptosporangiales	201174|Actinobacteria	C	Molybdopterin oxidoreductase	fdnG	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdopterin,Molydop_binding
REGS3_k127_4912680_16	666684.AfiDRAFT_3438	1.517e-30	122.0	COG3383@1|root,COG3383@2|Bacteria,1NZ71@1224|Proteobacteria,2USYP@28211|Alphaproteobacteria,3K49K@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Molybdopterin oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Molybdopterin
REGS3_k127_4912680_8	1313172.YM304_33540	3.884e-118	387.0	COG0190@1|root,COG0190@2|Bacteria,2GJZS@201174|Actinobacteria,4CN0K@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	-	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
REGS3_k127_4912680_2	2074.JNYD01000002_gene5781	1.182e-298	925.0	COG2759@1|root,COG2759@2|Bacteria,2GT0X@201174|Actinobacteria,4DXJB@85010|Pseudonocardiales	201174|Actinobacteria	F	Belongs to the formate--tetrahydrofolate ligase family	fhs	-	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
REGS3_k127_4912680_12	405948.SACE_5618	7.877e-58	214.0	COG0685@1|root,COG0685@2|Bacteria,2I92A@201174|Actinobacteria,4E35Z@85010|Pseudonocardiales	201174|Actinobacteria	E	Methylenetetrahydrofolate reductase	-	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
REGS3_k127_4912680_15	66377.JOBH01000004_gene3936	7.087e-38	151.0	COG1414@1|root,COG1414@2|Bacteria,2GM23@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR
REGS3_k127_4912680_11	1395571.TMS3_0103315	2.301e-61	226.0	COG0477@1|root,COG2814@2|Bacteria,1MVUF@1224|Proteobacteria,1RP39@1236|Gammaproteobacteria	1236|Gammaproteobacteria	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
REGS3_k127_4912680_7	1313172.YM304_35690	7.11e-119	385.0	COG5012@1|root,COG5012@2|Bacteria,2IEGQ@201174|Actinobacteria	201174|Actinobacteria	S	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,B12-binding_2
REGS3_k127_4912680_13	1089551.KE386572_gene3994	3.465e-55	201.0	28I8Y@1|root,2Z8BR@2|Bacteria,1MXN1@1224|Proteobacteria,2TRAQ@28211|Alphaproteobacteria,4BQ8X@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1638)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1638
REGS3_k127_4912680_17	1300350.DSW25_04120	4.926e-23	105.0	2CDZD@1|root,32RYT@2|Bacteria,1N0AT@1224|Proteobacteria,2UBTM@28211|Alphaproteobacteria,3ZXVX@60136|Sulfitobacter	28211|Alphaproteobacteria	S	Virulence factor	-	-	-	-	-	-	-	-	-	-	-	-	Virulence_fact
REGS3_k127_4912680_6	1313172.YM304_35710	1.658e-149	479.0	COG1410@1|root,COG1410@2|Bacteria,2IC7C@201174|Actinobacteria	201174|Actinobacteria	E	CO dehydrogenase/acetyl-CoA synthase delta subunit	-	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
REGS3_k127_4912680_3	1380391.JIAS01000001_gene2815	4.706e-247	779.0	COG0633@1|root,COG3894@1|root,COG0633@2|Bacteria,COG3894@2|Bacteria,1MV6C@1224|Proteobacteria,2TUJB@28211|Alphaproteobacteria,2JQGJ@204441|Rhodospirillales	204441|Rhodospirillales	C	Domain of unknown function (DUF4445)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
REGS3_k127_4912680_4	1380394.JADL01000010_gene4324	9.816e-227	719.0	COG5598@1|root,COG5598@2|Bacteria,1MWJN@1224|Proteobacteria,2TR0V@28211|Alphaproteobacteria,2JRHD@204441|Rhodospirillales	204441|Rhodospirillales	H	Trimethylamine methyltransferase (MTTB)	-	-	-	-	-	-	-	-	-	-	-	-	MTTB
REGS3_k127_4912680_1	43354.JOIJ01000002_gene4227	0.0	1080.0	COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,2GNCW@201174|Actinobacteria,4E1F5@85010|Pseudonocardiales	201174|Actinobacteria	E	Belongs to the GcvT family	-	-	-	-	-	-	-	-	-	-	-	-	DAO,FAO_M,GCV_T,GCV_T_C
REGS3_k127_4912680_10	446470.Snas_1823	2.331e-66	235.0	COG2086@1|root,COG2086@2|Bacteria,2IB9F@201174|Actinobacteria	201174|Actinobacteria	C	Electron transfer flavoprotein domain	-	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
REGS3_k127_4912680_9	1445613.JALM01000036_gene2875	1.108e-79	278.0	COG2025@1|root,COG2025@2|Bacteria,2I9CI@201174|Actinobacteria,4E0Z1@85010|Pseudonocardiales	201174|Actinobacteria	C	Electron transfer flavoprotein FAD-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	ETF,ETF_alpha
REGS3_k127_4912680_20	710111.FraQA3DRAFT_3563	6.061e-05	55.0	2E5WA@1|root,330KC@2|Bacteria,2HRPW@201174|Actinobacteria,4EWK1@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_4912680_0	1313172.YM304_33230	0.0	1097.0	COG1529@1|root,COG1529@2|Bacteria,2GIVI@201174|Actinobacteria,4CMUW@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
REGS3_k127_4912680_18	1313172.YM304_33210	7.656e-21	102.0	COG2919@1|root,COG2919@2|Bacteria	2|Bacteria	D	cell cycle	divIC	-	-	ko:K05589,ko:K13052	-	-	-	-	ko00000,ko03036	-	-	-	DivIC
REGS3_k127_4912680_5	1313172.YM304_33170	4.757e-217	679.0	COG0148@1|root,COG0148@2|Bacteria,2GJAY@201174|Actinobacteria,4CMRI@84992|Acidimicrobiia	84992|Acidimicrobiia	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
REGS3_k127_4912680_19	1313172.YM304_33140	4.671e-17	82.0	COG1694@1|root,COG3956@2|Bacteria,2GNKC@201174|Actinobacteria,4CN31@84992|Acidimicrobiia	84992|Acidimicrobiia	S	MazG nucleotide pyrophosphohydrolase domain	-	-	-	ko:K02499	-	-	-	-	ko00000,ko03036	-	-	-	MazG
REGS3_k127_4921371_2	858215.Thexy_1011	3.097e-60	218.0	COG0004@1|root,COG0004@2|Bacteria,1TQYG@1239|Firmicutes,247W1@186801|Clostridia,42FEB@68295|Thermoanaerobacterales	186801|Clostridia	P	TIGRFAM Ammonium transporter	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
REGS3_k127_4921371_0	572544.Ilyop_2918	4.889e-121	393.0	COG1028@1|root,COG1028@2|Bacteria,379JC@32066|Fusobacteria	32066|Fusobacteria	IQ	PFAM short-chain dehydrogenase reductase SDR	-	-	1.1.1.127	ko:K00065	ko00040,map00040	-	R01542	RC00089	ko00000,ko00001,ko01000	-	-	-	adh_short_C2
REGS3_k127_4921371_1	1265845.PWEIH_02012	9.239e-66	230.0	COG1070@1|root,COG1070@2|Bacteria,1TRY0@1239|Firmicutes,4HETG@91061|Bacilli,26MN7@186820|Listeriaceae	91061|Bacilli	G	FGGY family of carbohydrate kinases, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	FGGY_C,FGGY_N
REGS3_k127_4942509_2	1206726.BAFV01000109_gene5419	1.314e-54	195.0	COG1960@1|root,COG1960@2|Bacteria,2GM3V@201174|Actinobacteria,4FYJ1@85025|Nocardiaceae	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
REGS3_k127_4942509_1	1313172.YM304_15080	1.542e-85	291.0	2C8AG@1|root,33SQR@2|Bacteria,2H3BF@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_4942509_0	298655.KI912266_gene3216	1.069e-193	622.0	COG3653@1|root,COG3653@2|Bacteria,2GKMK@201174|Actinobacteria	201174|Actinobacteria	Q	N-acyl-D-aspartate D-glutamate deacylase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
REGS3_k127_5032679_2	1313172.YM304_37240	1.024e-130	426.0	COG1409@1|root,COG1409@2|Bacteria,2IDNH@201174|Actinobacteria	201174|Actinobacteria	S	Calcineurin-like phosphoesterase	-	-	3.1.4.53	ko:K03651	ko00230,ko02025,map00230,map02025	-	R00191	RC00296	ko00000,ko00001,ko01000	-	-	-	Metallophos,Pur_ac_phosph_N
REGS3_k127_5032679_7	1121363.KB902238_gene959	9.764e-24	109.0	29V0V@1|root,31YP4@2|Bacteria,2I035@201174|Actinobacteria,22QR0@1653|Corynebacteriaceae	201174|Actinobacteria	S	Mycothiol maleylpyruvate isomerase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_N
REGS3_k127_5032679_3	331869.BAL199_05779	2.971e-116	391.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,2TS06@28211|Alphaproteobacteria,4BPFS@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Aminotransferase class I and II	aspB	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
REGS3_k127_5032679_0	1313172.YM304_02580	2.162e-172	550.0	COG1804@1|root,COG1804@2|Bacteria,2GIU7@201174|Actinobacteria	201174|Actinobacteria	C	L-carnitine dehydratase bile acid-inducible protein F	-	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
REGS3_k127_5032679_4	1148.1651696	3.146e-102	340.0	COG0225@1|root,COG0225@2|Bacteria,1G1QF@1117|Cyanobacteria,1H4VX@1142|Synechocystis	1117|Cyanobacteria	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
REGS3_k127_5032679_1	1313172.YM304_03250	6.235e-146	475.0	COG1804@1|root,COG1804@2|Bacteria,2IB98@201174|Actinobacteria	201174|Actinobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
REGS3_k127_5032679_5	700508.D174_03870	3.307e-90	303.0	COG0494@1|root,COG0494@2|Bacteria,2II41@201174|Actinobacteria,232BI@1762|Mycobacteriaceae	201174|Actinobacteria	L	Belongs to the NUDIX hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
REGS3_k127_5032679_6	1172186.KB911469_gene2582	8.376e-56	199.0	COG0596@1|root,COG0596@2|Bacteria,2GY3A@201174|Actinobacteria,236DE@1762|Mycobacteriaceae	201174|Actinobacteria	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
REGS3_k127_510753_10	445972.ANACOL_02136	1.796e-30	121.0	2AU0F@1|root,31JKB@2|Bacteria,1V6XX@1239|Firmicutes,24KKM@186801|Clostridia,3WK45@541000|Ruminococcaceae	186801|Clostridia	S	COG NOG14600 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_510753_9	1313172.YM304_26430	1.485e-50	196.0	COG0457@1|root,COG0457@2|Bacteria,2HGAM@201174|Actinobacteria,4CNA6@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_510753_12	1313172.YM304_24830	4.143e-16	83.0	COG0629@1|root,COG0629@2|Bacteria	2|Bacteria	L	single-stranded DNA binding	ssb	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
REGS3_k127_510753_2	1229780.BN381_290092	1.028e-178	567.0	COG1830@1|root,COG1830@2|Bacteria,2I9V1@201174|Actinobacteria	201174|Actinobacteria	G	PFAM deoxyribose-phosphate aldolase phospho-2- dehydro-3-deoxyheptonate aldolase	-	-	4.1.2.13	ko:K11645	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	DeoC
REGS3_k127_510753_3	1193181.BN10_1180005	3.047e-132	433.0	COG4198@1|root,COG4198@2|Bacteria,2GJFV@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF1015)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1015
REGS3_k127_510753_7	1313172.YM304_24850	1.581e-71	254.0	COG0647@1|root,COG0647@2|Bacteria,2GK7V@201174|Actinobacteria,4CN5Z@84992|Acidimicrobiia	84992|Acidimicrobiia	G	Haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_6,Hydrolase_like
REGS3_k127_510753_6	1313172.YM304_24870	3.971e-89	300.0	COG1189@1|root,COG1189@2|Bacteria,2GJVT@201174|Actinobacteria,4CN67@84992|Acidimicrobiia	84992|Acidimicrobiia	J	FtsJ-like methyltransferase	-	-	2.1.1.226,2.1.1.227	ko:K06442	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ,S4
REGS3_k127_510753_4	1313172.YM304_24880	7.74e-100	333.0	COG0061@1|root,COG0061@2|Bacteria,2GKM2@201174|Actinobacteria,4CN3D@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
REGS3_k127_510753_1	1313172.YM304_24890	2.493e-188	601.0	COG0497@1|root,COG0497@2|Bacteria,2GIVG@201174|Actinobacteria,4CMY1@84992|Acidimicrobiia	84992|Acidimicrobiia	L	May be involved in recombinational repair of damaged DNA	recN	-	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	SMC_N
REGS3_k127_510753_0	1313172.YM304_24900	4.337e-292	903.0	COG0504@1|root,COG0504@2|Bacteria,2GJ13@201174|Actinobacteria,4CMQD@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
REGS3_k127_510753_8	1313172.YM304_24910	1.848e-60	216.0	COG0494@1|root,COG0494@2|Bacteria,2GNW6@201174|Actinobacteria,4CNBA@84992|Acidimicrobiia	84992|Acidimicrobiia	L	NUDIX domain	nudF	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
REGS3_k127_510753_5	1313172.YM304_24920	4.712e-94	314.0	COG4974@1|root,COG4974@2|Bacteria,2GNDP@201174|Actinobacteria,4CMZU@84992|Acidimicrobiia	84992|Acidimicrobiia	D	Phage integrase, N-terminal SAM-like domain	xerC	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
REGS3_k127_5133858_1	1268072.PSAB_09295	9.61e-16	86.0	COG1653@1|root,COG1653@2|Bacteria,1TS64@1239|Firmicutes,4HARC@91061|Bacilli,274JR@186822|Paenibacillaceae	91061|Bacilli	G	ABC-type sugar transport system, periplasmic component	upgB	-	-	ko:K05813	ko02010,map02010	M00198	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.3	-	-	SBP_bac_8
REGS3_k127_5133858_0	1313172.YM304_01580	2.766e-262	820.0	COG1529@1|root,COG2080@1|root,COG1529@2|Bacteria,COG2080@2|Bacteria,2GIVI@201174|Actinobacteria	201174|Actinobacteria	C	aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2,Fer2_2
REGS3_k127_5199604_0	1313172.YM304_20460	0.0	1227.0	COG0458@1|root,COG0458@2|Bacteria,2GK5N@201174|Actinobacteria,4CMUA@84992|Acidimicrobiia	84992|Acidimicrobiia	EF	Carbamoyl-phosphate synthetase large chain, oligomerisation domain	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
REGS3_k127_5199604_8	1313172.YM304_20450	2.683e-147	476.0	COG0505@1|root,COG0505@2|Bacteria,2GKFA@201174|Actinobacteria,4CMXV@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Carbamoyl-phosphate synthase small chain, CPSase domain	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
REGS3_k127_5199604_6	1313172.YM304_20440	4.464e-174	559.0	COG0044@1|root,COG0044@2|Bacteria,2GJ0T@201174|Actinobacteria,4CN0V@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	pyrC	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
REGS3_k127_5199604_9	1313172.YM304_20430	9.229e-136	439.0	COG0540@1|root,COG0540@2|Bacteria,2GKNA@201174|Actinobacteria,4CN9W@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain	pyrB	-	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
REGS3_k127_5199604_21	1313172.YM304_20420	7.812e-74	254.0	COG2065@1|root,COG2065@2|Bacteria,2GJNP@201174|Actinobacteria,4CNB0@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Phosphoribosyl transferase domain	pyrR	-	2.4.2.9	ko:K02825	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000,ko03000	-	-	-	Pribosyltran
REGS3_k127_5199604_25	1313172.YM304_20390	5.326e-44	164.0	COG0781@1|root,COG0781@2|Bacteria,2IM3D@201174|Actinobacteria,4CNC8@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
REGS3_k127_5199604_18	1313172.YM304_20380	4.549e-85	286.0	COG0231@1|root,COG0231@2|Bacteria,2GJMS@201174|Actinobacteria,4CMZZ@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	efp	-	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
REGS3_k127_5199604_20	1050202.KB913024_gene1046	7.183e-80	281.0	COG0006@1|root,COG0006@2|Bacteria,2GM7D@201174|Actinobacteria,407VK@622450|Actinopolysporales	201174|Actinobacteria	E	Creatinase/Prolidase N-terminal domain	pepQ	GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0016787,GO:0019538,GO:0030145,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.11.9,3.4.13.9	ko:K01262,ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
REGS3_k127_5199604_24	1229780.BN381_50135	4.839e-49	181.0	COG0757@1|root,COG0757@2|Bacteria,2IMBY@201174|Actinobacteria,3UWWA@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	E	Catalyzes a trans-dehydration via an enolate intermediate	aroQ	-	4.2.1.10	ko:K03786,ko:K16021	ko00400,ko01051,ko01100,ko01110,ko01130,ko01230,map00400,map01051,map01100,map01110,map01130,map01230	M00022	R03084,R06593	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_II
REGS3_k127_5199604_3	1313172.YM304_21270	2.406e-213	673.0	COG0204@1|root,COG0560@1|root,COG0204@2|Bacteria,COG0560@2|Bacteria,2GJVX@201174|Actinobacteria	201174|Actinobacteria	E	HAD-superfamily subfamily IB hydrolase, TIGR01490	-	-	2.3.1.51,3.1.3.3	ko:K15781	-	-	-	-	ko00000,ko01000	-	-	-	Acyltransferase,HAD
REGS3_k127_5199604_14	1313172.YM304_21260	7.966e-115	377.0	COG0583@1|root,COG0583@2|Bacteria,2HF8Y@201174|Actinobacteria,4CN2C@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	ko:K04761	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_1,LysR_substrate
REGS3_k127_5199604_5	1313172.YM304_21250	3.987e-187	595.0	COG4799@1|root,COG4799@2|Bacteria,2GIRU@201174|Actinobacteria,4CMQK@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Carboxyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Carboxyl_trans
REGS3_k127_5199604_2	1313172.YM304_21230	1.315e-219	687.0	COG0372@1|root,COG0372@2|Bacteria,2GJ7E@201174|Actinobacteria,4CMS9@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Citrate synthase, C-terminal domain	-	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
REGS3_k127_5199604_11	1313172.YM304_38560	3.909e-127	415.0	COG0604@1|root,COG0604@2|Bacteria,2GN47@201174|Actinobacteria,4CN5N@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
REGS3_k127_5199604_16	1313172.YM304_23490	8.197e-110	376.0	COG3848@1|root,COG3848@2|Bacteria,2IE61@201174|Actinobacteria	201174|Actinobacteria	T	PEP-utilising enzyme, mobile domain	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers
REGS3_k127_5199604_27	1121946.AUAX01000012_gene6686	8.9e-34	142.0	COG0546@1|root,COG0546@2|Bacteria,2I3FJ@201174|Actinobacteria,4DC9K@85008|Micromonosporales	201174|Actinobacteria	S	HAD-hyrolase-like	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
REGS3_k127_5199604_1	1379270.AUXF01000003_gene3603	8.867e-244	755.0	COG0538@1|root,COG0538@2|Bacteria,1ZUHH@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Isocitrate/isopropylmalate dehydrogenase	-	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
REGS3_k127_5199604_29	525904.Tter_1588	2.805e-11	70.0	COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,2NNSH@2323|unclassified Bacteria	2|Bacteria	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	coxB	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009319,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016310,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0034641,GO:0042773,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0055086,GO:0055114,GO:0070069,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:1901135,GO:1901360,GO:1901564,GO:1902494	1.9.3.1	ko:K02275,ko:K17223	ko00190,ko00920,ko01100,ko01120,map00190,map00920,map01100,map01120	M00155,M00595	R00081,R10151	RC00016,RC03151,RC03152	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM,Cytochrom_C,Cytochrome_CBB3
REGS3_k127_5199604_19	298655.KI912267_gene7117	7.831e-85	291.0	COG2175@1|root,COG2175@2|Bacteria,2GNUC@201174|Actinobacteria	201174|Actinobacteria	Q	taurine catabolism dioxygenase	tauD	-	1.14.11.17	ko:K03119,ko:K22303	ko00430,ko00920,map00430,map00920	-	R05320	RC01331	ko00000,ko00001,ko01000	-	-	-	TauD
REGS3_k127_5199604_4	1313172.YM304_21200	5.698e-198	621.0	COG1960@1|root,COG1960@2|Bacteria,2GJ7S@201174|Actinobacteria	201174|Actinobacteria	I	acyl-CoA dehydrogenase	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
REGS3_k127_5199604_12	266117.Rxyl_1742	3.506e-119	398.0	COG1131@1|root,COG1131@2|Bacteria,2GKI7@201174|Actinobacteria,4CP6S@84995|Rubrobacteria	84995|Rubrobacteria	V	Daunorubicin resistance ABC transporter ATP-binding subunit	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
REGS3_k127_5199604_17	266117.Rxyl_1743	4.158e-102	338.0	COG0842@1|root,COG0842@2|Bacteria,2IPQ3@201174|Actinobacteria,4CT8V@84995|Rubrobacteria	84995|Rubrobacteria	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
REGS3_k127_5199604_7	1313172.YM304_41990	5.84e-164	527.0	COG2015@1|root,COG2015@2|Bacteria,2H3T3@201174|Actinobacteria	201174|Actinobacteria	Q	Alkyl sulfatase dimerisation	-	-	-	-	-	-	-	-	-	-	-	-	Alkyl_sulf_dimr,Lactamase_B
REGS3_k127_5199604_23	35754.JNYJ01000065_gene5671	1.357e-49	187.0	COG0697@1|root,COG0697@2|Bacteria,2GM50@201174|Actinobacteria,4DDPM@85008|Micromonosporales	201174|Actinobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
REGS3_k127_5199604_10	448385.sce2610	6.12e-132	438.0	COG0667@1|root,COG0667@2|Bacteria,1MV2Y@1224|Proteobacteria	1224|Proteobacteria	C	Aldo Keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
REGS3_k127_5199604_26	1313172.YM304_21170	7.857e-34	138.0	2DW3A@1|root,33YCP@2|Bacteria,2GZ8M@201174|Actinobacteria	201174|Actinobacteria	S	Anti-sigma-K factor rskA	-	-	-	-	-	-	-	-	-	-	-	-	RskA
REGS3_k127_5199604_22	1283283.ATXA01000003_gene1646	1.698e-57	206.0	COG1595@1|root,COG1595@2|Bacteria,2IKQ7@201174|Actinobacteria,4EVJY@85013|Frankiales	201174|Actinobacteria	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
REGS3_k127_5199604_15	1229780.BN381_130130	6.388e-110	370.0	COG0477@1|root,COG0477@2|Bacteria,2GK06@201174|Actinobacteria,3UWB0@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	U	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
REGS3_k127_5199604_30	1120954.ATXE01000004_gene61	3.84e-09	65.0	COG1846@1|root,COG1846@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
REGS3_k127_5199604_13	402881.Plav_1983	1.364e-116	386.0	COG3618@1|root,COG3618@2|Bacteria,1MVG0@1224|Proteobacteria,2TRU9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	metal-dependent hydrolase of the TIM-barrel fold	-	-	-	ko:K07046	ko00051,ko01120,map00051,map01120	-	R10689	RC00537	ko00000,ko00001,ko01000	-	-	-	Amidohydro_2
REGS3_k127_5199604_32	1298864.AUEQ01000001_gene4128	4.963e-05	54.0	COG2114@1|root,COG2909@1|root,COG3629@1|root,COG2114@2|Bacteria,COG2909@2|Bacteria,COG3629@2|Bacteria,2GJAR@201174|Actinobacteria,2349V@1762|Mycobacteriaceae	201174|Actinobacteria	K	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD,Guanylate_cyc,Trans_reg_C
REGS3_k127_5199604_28	398578.Daci_5804	1.547e-26	126.0	COG1361@1|root,COG3055@1|root,COG3468@1|root,COG4625@1|root,COG1361@2|Bacteria,COG3055@2|Bacteria,COG3468@2|Bacteria,COG4625@2|Bacteria,1QU2X@1224|Proteobacteria,2VHDJ@28216|Betaproteobacteria	28216|Betaproteobacteria	MU	TIGRFAM outer membrane autotransporter barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Autotransporter,He_PIG,TIG
REGS3_k127_5213323_0	1313172.YM304_36150	0.0	1029.0	COG0210@1|root,COG0210@2|Bacteria,2GISS@201174|Actinobacteria,4CMS6@84992|Acidimicrobiia	84992|Acidimicrobiia	L	UvrD-like helicase C-terminal domain	pcrA	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
REGS3_k127_5213323_7	1005048.CFU_4221	3.865e-111	373.0	COG0038@1|root,COG0038@2|Bacteria,1MV4K@1224|Proteobacteria,2VIIM@28216|Betaproteobacteria,4724X@75682|Oxalobacteraceae	28216|Betaproteobacteria	P	Voltage gated chloride channel	-	-	-	-	-	-	-	-	-	-	-	-	Voltage_CLC
REGS3_k127_5213323_12	196162.Noca_2782	1.338e-39	154.0	COG3132@1|root,COG4106@1|root,COG3132@2|Bacteria,COG4106@2|Bacteria,2I5BV@201174|Actinobacteria,4DRTB@85009|Propionibacteriales	201174|Actinobacteria	E	Protein of unknown function, DUF480	-	-	-	ko:K09915	-	-	-	-	ko00000	-	-	-	DUF480,Methyltransf_25
REGS3_k127_5213323_10	1370125.AUWT01000023_gene5796	1.28e-62	230.0	COG2141@1|root,COG2141@2|Bacteria,2GMUE@201174|Actinobacteria,236IS@1762|Mycobacteriaceae	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
REGS3_k127_5213323_11	1313172.YM304_36130	1.259e-46	173.0	COG0716@1|root,COG0716@2|Bacteria	2|Bacteria	C	FMN binding	fldA	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_4
REGS3_k127_5213323_8	298655.KI912266_gene2297	5.817e-88	306.0	COG4826@1|root,COG4826@2|Bacteria,2GJ5T@201174|Actinobacteria,4EVB8@85013|Frankiales	201174|Actinobacteria	O	SERine  Proteinase INhibitors	-	-	-	ko:K13963	ko05146,map05146	-	-	-	ko00000,ko00001	-	-	-	Serpin
REGS3_k127_5213323_9	1313172.YM304_36110	4.114e-68	233.0	COG2185@1|root,COG2185@2|Bacteria,2IFJD@201174|Actinobacteria,4CN3T@84992|Acidimicrobiia	84992|Acidimicrobiia	I	B12 binding domain	-	-	5.4.99.2	ko:K01849	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding
REGS3_k127_5213323_1	1313172.YM304_36100	1.134e-188	595.0	COG0045@1|root,COG0045@2|Bacteria,2GKSB@201174|Actinobacteria,4CMVM@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
REGS3_k127_5213323_3	1313172.YM304_36090	1.297e-159	506.0	COG0074@1|root,COG0074@2|Bacteria,2GK00@201174|Actinobacteria,4CMSK@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA
REGS3_k127_5213323_2	1229780.BN381_130062	3.403e-179	575.0	COG0138@1|root,COG0138@2|Bacteria,2GJWU@201174|Actinobacteria,3UW6K@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	F	AICARFT/IMPCHase bienzyme	purH	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
REGS3_k127_5213323_6	1313172.YM304_07250	7.122e-118	385.0	COG0685@1|root,COG0685@2|Bacteria,2GJTN@201174|Actinobacteria,4CN4K@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Methylenetetrahydrofolate reductase	metF	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
REGS3_k127_5213323_5	1313172.YM304_07260	8.991e-148	491.0	COG1835@1|root,COG2755@1|root,COG1835@2|Bacteria,COG2755@2|Bacteria,2GKI5@201174|Actinobacteria,4CNC6@84992|Acidimicrobiia	201174|Actinobacteria	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
REGS3_k127_5213323_4	526227.Mesil_1713	3.349e-159	509.0	COG0039@1|root,COG0039@2|Bacteria,1WJHY@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006107,GO:0006108,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009060,GO:0009117,GO:0009987,GO:0015980,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0016999,GO:0017144,GO:0019362,GO:0019637,GO:0019674,GO:0019752,GO:0030060,GO:0034641,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046483,GO:0046496,GO:0051186,GO:0055086,GO:0055114,GO:0071704,GO:0072350,GO:0072524,GO:1901360,GO:1901564	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
REGS3_k127_5229254_5	298654.FraEuI1c_3294	1.433e-67	236.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4ES6E@85013|Frankiales	201174|Actinobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
REGS3_k127_5229254_1	1123320.KB889562_gene6568	5.179e-184	583.0	COG2159@1|root,COG2159@2|Bacteria,2GKG2@201174|Actinobacteria	201174|Actinobacteria	S	Pfam Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
REGS3_k127_5229254_3	298655.KI912266_gene3812	1.688e-68	242.0	COG4221@1|root,COG4221@2|Bacteria,2IGP3@201174|Actinobacteria	201174|Actinobacteria	S	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
REGS3_k127_5229254_0	298655.KI912266_gene5581	3.929e-206	647.0	COG2159@1|root,COG2159@2|Bacteria,2GKG2@201174|Actinobacteria	201174|Actinobacteria	S	Pfam Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
REGS3_k127_5229254_2	1463820.JOGW01000004_gene4552	5.156e-93	316.0	COG2141@1|root,COG2141@2|Bacteria,2IB78@201174|Actinobacteria	201174|Actinobacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
REGS3_k127_5229254_4	1386969.AWTB01000093_gene4358	2.241e-68	244.0	COG1028@1|root,COG1028@2|Bacteria,2GJ1F@201174|Actinobacteria,4GDUH@85026|Gordoniaceae	201174|Actinobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
REGS3_k127_5238326_1	2045.KR76_08655	1.513e-99	343.0	COG2755@1|root,COG2755@2|Bacteria,2GKSW@201174|Actinobacteria,4DPUD@85009|Propionibacteriales	201174|Actinobacteria	E	lipolytic protein G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_5238326_4	1120950.KB892768_gene5225	5.426e-65	231.0	COG0730@1|root,COG0730@2|Bacteria	2|Bacteria	S	response to heat	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
REGS3_k127_5238326_3	471857.Svir_26180	3.427e-68	241.0	COG0583@1|root,COG0583@2|Bacteria,2HGRW@201174|Actinobacteria,4E3BA@85010|Pseudonocardiales	201174|Actinobacteria	K	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
REGS3_k127_5238326_0	1429916.X566_10345	4.423e-132	433.0	COG2124@1|root,COG2124@2|Bacteria,1MY5H@1224|Proteobacteria,2TR6X@28211|Alphaproteobacteria,3JU3Z@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Cytochrome P450	MA20_16575	-	-	-	-	-	-	-	-	-	-	-	p450
REGS3_k127_5238326_2	479431.Namu_3645	4.653e-72	251.0	COG2345@1|root,COG2345@2|Bacteria,2HCEF@201174|Actinobacteria,4ESVJ@85013|Frankiales	201174|Actinobacteria	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
REGS3_k127_5238326_6	1386089.N865_10085	6.771e-48	176.0	2BVXR@1|root,32IG2@2|Bacteria,2IMT1@201174|Actinobacteria,4FGU2@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DoxX
REGS3_k127_5238326_5	515635.Dtur_0861	1.412e-56	203.0	COG1803@1|root,COG1803@2|Bacteria	2|Bacteria	G	methylglyoxal synthase activity	mgsA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0008150,GO:0008152,GO:0008929,GO:0009058,GO:0009438,GO:0009987,GO:0016829,GO:0016835,GO:0016838,GO:0019242,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0071704,GO:1901576	4.2.3.3	ko:K01734	ko00640,ko01120,map00640,map01120	-	R01016	RC00424	ko00000,ko00001,ko01000	-	-	iECUMN_1333.ECUMN_1153,iYL1228.KPN_00992	MGS
REGS3_k127_5238326_7	710686.Mycsm_03092	4.973e-46	173.0	COG3467@1|root,COG3467@2|Bacteria,2IG17@201174|Actinobacteria,238QA@1762|Mycobacteriaceae	201174|Actinobacteria	S	Pyridoxamine 5-phosphate	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
REGS3_k127_5238326_8	326424.FRAAL3029	7.915e-37	141.0	COG3832@1|root,COG3832@2|Bacteria,2I8ND@201174|Actinobacteria	201174|Actinobacteria	S	Activator of Hsp90 ATPase	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
REGS3_k127_5260582_3	391625.PPSIR1_24954	3.781e-06	49.0	COG1225@1|root,COG1225@2|Bacteria,1NN23@1224|Proteobacteria,42XJF@68525|delta/epsilon subdivisions,2WTAE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	AhpC/TSA antioxidant enzyme	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA_2
REGS3_k127_5260582_2	1313172.YM304_03500	1.388e-131	428.0	COG1162@1|root,COG1162@2|Bacteria,2GMDX@201174|Actinobacteria	201174|Actinobacteria	S	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit	rsgA	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	RsgA_GTPase
REGS3_k127_5260582_0	66373.JOFQ01000031_gene3974	6.258e-157	499.0	COG0667@1|root,COG0667@2|Bacteria,2GMNA@201174|Actinobacteria	201174|Actinobacteria	C	aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
REGS3_k127_5260582_1	936455.KI421499_gene1781	4.362e-152	494.0	COG1926@1|root,COG2312@1|root,COG1926@2|Bacteria,COG2312@2|Bacteria,1RAG8@1224|Proteobacteria,2U5HS@28211|Alphaproteobacteria,3JZK6@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Phosphoribosyl transferase domain	-	-	-	ko:K07100	-	-	-	-	ko00000	-	-	-	Pribosyltran
REGS3_k127_5261824_13	40571.JOEA01000022_gene6981	6.429e-13	82.0	COG3021@1|root,COG3021@2|Bacteria,2GKXC@201174|Actinobacteria,4DZ69@85010|Pseudonocardiales	201174|Actinobacteria	S	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
REGS3_k127_5261824_9	743720.Psefu_1073	1.689e-45	174.0	COG1183@1|root,COG1183@2|Bacteria,1NGCJ@1224|Proteobacteria,1S88D@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Condenses choline with CDP-diglyceride to produce phosphatidylcholine and CMP	lidK	GO:0003674,GO:0003824,GO:0006629,GO:0006644,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0050520,GO:0071704,GO:0090407,GO:1901576	2.7.8.24	ko:K01004	ko00564,ko01110,map00564,map01110	-	R05794	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
REGS3_k127_5261824_2	1229780.BN381_210110	1.123e-180	574.0	COG1960@1|root,COG1960@2|Bacteria,2HY6H@201174|Actinobacteria	201174|Actinobacteria	I	acyl-CoA dehydrogenase	fadE21	-	-	ko:K00257	-	-	R04547,R04592	RC01942	ko00000,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
REGS3_k127_5261824_11	1380354.JIAN01000005_gene2126	6.018e-25	117.0	COG0346@1|root,COG0346@2|Bacteria,2IN2S@201174|Actinobacteria	201174|Actinobacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
REGS3_k127_5261824_7	1211815.CBYP010000004_gene1014	1.283e-74	263.0	COG1878@1|root,COG1878@2|Bacteria,2I66K@201174|Actinobacteria,4EVKZ@85013|Frankiales	201174|Actinobacteria	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
REGS3_k127_5261824_12	390989.JOEG01000003_gene4637	5.173e-22	111.0	COG1835@1|root,COG1835@2|Bacteria,2GN56@201174|Actinobacteria,4DC3S@85008|Micromonosporales	201174|Actinobacteria	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
REGS3_k127_5261824_0	1229780.BN381_80185	5.095e-223	710.0	COG1164@1|root,COG1164@2|Bacteria,2IGPX@201174|Actinobacteria	201174|Actinobacteria	E	Oligopeptidase F	pepF	-	-	ko:K08602	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3,Peptidase_M3_N
REGS3_k127_5261824_4	1313172.YM304_26870	5.216e-93	308.0	COG1435@1|root,COG1435@2|Bacteria,2GP1W@201174|Actinobacteria	201174|Actinobacteria	F	Thymidine kinase	tdk	GO:0003674,GO:0003824,GO:0004797,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006259,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009120,GO:0009123,GO:0009124,GO:0009157,GO:0009162,GO:0009165,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0018130,GO:0019136,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046104,GO:0046125,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0090304,GO:0090407,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657	2.7.1.21	ko:K00857	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01567,R02099,R08233	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	TK
REGS3_k127_5261824_1	1313172.YM304_26850	3.607e-197	621.0	COG2124@1|root,COG2124@2|Bacteria,2GKCG@201174|Actinobacteria,4CNFD@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Cytochrome P450	-	-	1.14.15.14	ko:K20497	-	-	-	-	ko00000,ko00199,ko01000	-	-	-	p450
REGS3_k127_5261824_6	1313172.YM304_26840	3.075e-85	288.0	COG2120@1|root,COG2120@2|Bacteria,2GMVD@201174|Actinobacteria,4CMYW@84992|Acidimicrobiia	84992|Acidimicrobiia	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
REGS3_k127_5261824_3	1229780.BN381_90096	1.254e-174	556.0	COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria,3UX13@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	I	Thiolase, C-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
REGS3_k127_5261824_5	1313172.YM304_26790	5.529e-90	306.0	COG1680@1|root,COG1680@2|Bacteria,2GNVX@201174|Actinobacteria,4CP4T@84992|Acidimicrobiia	84992|Acidimicrobiia	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
REGS3_k127_5261824_8	1313172.YM304_26780	2.252e-49	177.0	COG3200@1|root,COG3200@2|Bacteria,2GJBX@201174|Actinobacteria,4CMTE@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Class-II DAHP synthetase family	-	-	2.5.1.54	ko:K01626	ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_2
REGS3_k127_5262270_7	1304865.JAGF01000001_gene1369	3.95e-41	161.0	COG4585@1|root,COG4585@2|Bacteria,2IAG1@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3,PAS_9,Response_reg
REGS3_k127_5262270_2	1313172.YM304_38960	3.985e-187	619.0	COG0141@1|root,COG0141@2|Bacteria,2GKKA@201174|Actinobacteria,4CN2M@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	-	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
REGS3_k127_5262270_0	1313172.YM304_38930	4.21e-204	642.0	COG0104@1|root,COG0104@2|Bacteria,2GMP4@201174|Actinobacteria,4CMR5@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
REGS3_k127_5262270_1	1313172.YM304_38920	3.082e-202	638.0	COG0015@1|root,COG0015@2|Bacteria,2GKBR@201174|Actinobacteria,4CMWU@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Adenylosuccinate lyase C-terminus	purB	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
REGS3_k127_5262270_8	1313172.YM304_38910	1.073e-33	135.0	2A58G@1|root,30TXM@2|Bacteria,2HG9Z@201174|Actinobacteria,4CN8R@84992|Acidimicrobiia	84992|Acidimicrobiia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_5262270_4	1313172.YM304_38900	7.072e-103	345.0	COG1946@1|root,COG1946@2|Bacteria,2GJ1B@201174|Actinobacteria,4CMRR@84992|Acidimicrobiia	201174|Actinobacteria	I	Thioesterase-like superfamily	-	-	-	ko:K10805	ko01040,map01040	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	-	4HBT_3
REGS3_k127_5262270_6	1313172.YM304_38880	3.894e-76	263.0	COG0461@1|root,COG0461@2|Bacteria,2HG8J@201174|Actinobacteria,4CN64@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	-
REGS3_k127_5262270_3	62928.azo1490	3.788e-103	363.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,2KV1U@206389|Rhodocyclales	206389|Rhodocyclales	T	GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF_2,GGDEF,PAS_9,Response_reg
REGS3_k127_5262270_5	1192034.CAP_1512	6.983e-100	338.0	COG0265@1|root,COG3287@1|root,COG0265@2|Bacteria,COG3287@2|Bacteria,1QUQH@1224|Proteobacteria,42Q8C@68525|delta/epsilon subdivisions,2WWR9@28221|Deltaproteobacteria,2YU1Q@29|Myxococcales	28221|Deltaproteobacteria	M	FIST N domain	-	-	-	-	-	-	-	-	-	-	-	-	FIST,FIST_C
REGS3_k127_5285172_0	1313172.YM304_00590	0.0	1516.0	COG2902@1|root,COG2902@2|Bacteria,2GK0C@201174|Actinobacteria,4CMVU@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Bacterial NAD-glutamate dehydrogenase	-	-	1.4.1.2	ko:K15371	ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100	-	R00243	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	Bac_GDH
REGS3_k127_5285172_15	1206720.BAFQ01000139_gene3529	5.574e-29	121.0	COG5517@1|root,COG5517@2|Bacteria,2IIIU@201174|Actinobacteria,4G0YC@85025|Nocardiaceae	201174|Actinobacteria	Q	Ring hydroxylating beta subunit	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_4
REGS3_k127_5285172_11	1449976.KALB_2267	1.272e-57	214.0	COG1752@1|root,COG1752@2|Bacteria,2GNBM@201174|Actinobacteria,4E21F@85010|Pseudonocardiales	201174|Actinobacteria	S	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
REGS3_k127_5285172_3	1313172.YM304_13330	1.707e-199	631.0	COG0008@1|root,COG0008@2|Bacteria,2GJJS@201174|Actinobacteria,4CMQ4@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
REGS3_k127_5285172_10	1313172.YM304_13340	7.668e-65	230.0	COG1434@1|root,COG1434@2|Bacteria,2I2NF@201174|Actinobacteria	201174|Actinobacteria	S	DUF218 domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF218
REGS3_k127_5285172_18	390989.JOEG01000002_gene4371	1.793e-10	75.0	COG1595@1|root,COG1595@2|Bacteria,2GP81@201174|Actinobacteria,4DEJJ@85008|Micromonosporales	201174|Actinobacteria	K	Sigma-70, region 4	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
REGS3_k127_5285172_13	1128421.JAGA01000003_gene3369	1.399e-42	168.0	COG0673@1|root,COG0673@2|Bacteria,2NP86@2323|unclassified Bacteria	2|Bacteria	C	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
REGS3_k127_5285172_5	1303518.CCALI_01151	1.627e-157	505.0	COG2115@1|root,COG2115@2|Bacteria	2|Bacteria	G	xylose isomerase activity	xylA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0009045,GO:0009056,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019323,GO:0042732,GO:0042843,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046365,GO:0071704,GO:1901575	5.3.1.5	ko:K01805	ko00040,ko00051,ko01100,map00040,map00051,map01100	-	R00878,R01432	RC00376,RC00516	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
REGS3_k127_5285172_8	998674.ATTE01000001_gene2556	7.735e-101	338.0	COG1129@1|root,COG1129@2|Bacteria,1MU22@1224|Proteobacteria,1RMCH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	import. Responsible for energy coupling to the transport system	-	-	3.6.3.17	ko:K02056,ko:K10441,ko:K10545	ko02010,map02010	M00212,M00215,M00221	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19,3.A.1.2.4	-	-	ABC_tran
REGS3_k127_5285172_6	1156935.QWE_16013	2.088e-115	388.0	COG4214@1|root,COG4214@2|Bacteria,1MXXS@1224|Proteobacteria,2TR9B@28211|Alphaproteobacteria,4B9FP@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Belongs to the binding-protein-dependent transport system permease family	xylH	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0015144,GO:0015145,GO:0015749,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0034219,GO:0044425,GO:0044464,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944	-	ko:K10544	ko02010,map02010	M00215	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.4	-	-	BPD_transp_2
REGS3_k127_5285172_7	272942.RCAP_rcc00018	3.106e-115	383.0	COG4213@1|root,COG4213@2|Bacteria,1MX63@1224|Proteobacteria,2TQQW@28211|Alphaproteobacteria,1FANV@1060|Rhodobacter	28211|Alphaproteobacteria	G	TIGRFAM D-xylose ABC transporter	xylF	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005975,GO:0005996,GO:0006810,GO:0008150,GO:0008152,GO:0008643,GO:0015749,GO:0015750,GO:0015753,GO:0019321,GO:0030246,GO:0030288,GO:0030313,GO:0031975,GO:0034219,GO:0036094,GO:0042597,GO:0042732,GO:0044238,GO:0044281,GO:0044464,GO:0048029,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071704	-	ko:K10543	ko02010,map02010	M00215	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.4	-	-	Peripla_BP_4
REGS3_k127_5285172_4	504728.K649_13805	2.367e-169	550.0	COG3118@1|root,COG3118@2|Bacteria	2|Bacteria	O	belongs to the thioredoxin family	-	-	-	ko:K20543	-	-	-	-	ko00000,ko02000	1.B.55.3	-	-	Arylsulfotran_2,UnbV_ASPIC,VCBS
REGS3_k127_5285172_9	1229780.BN381_80233	8.889e-87	308.0	COG4658@1|root,COG4658@2|Bacteria	2|Bacteria	C	electron transport chain	-	-	1.6.5.8	ko:K00347,ko:K03614,ko:K21163	ko01059,ko01130,map01059,map01130	M00824	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	Complex1_51K,NQR2_RnfD_RnfE,RnfC_N,UnbV_ASPIC,VCBS
REGS3_k127_5285172_17	1146883.BLASA_1347	9.966e-21	100.0	2DXTJ@1|root,346GW@2|Bacteria,2H9GA@201174|Actinobacteria	201174|Actinobacteria	S	Evidence 5 No homology to any previously reported sequences	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_5285172_14	103733.JNYO01000048_gene8472	2.562e-35	143.0	COG2203@1|root,COG2203@2|Bacteria,2GQ2V@201174|Actinobacteria,4E62F@85010|Pseudonocardiales	201174|Actinobacteria	T	ANTAR	-	-	-	-	-	-	-	-	-	-	-	-	ANTAR,GAF_2
REGS3_k127_5285172_2	1313172.YM304_13260	7.779e-207	648.0	COG1960@1|root,COG1960@2|Bacteria,2GIX8@201174|Actinobacteria,4CNIG@84992|Acidimicrobiia	2|Bacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
REGS3_k127_5285172_16	1123322.KB904659_gene1000	4.533e-24	108.0	COG3797@1|root,COG3797@2|Bacteria,2GPDB@201174|Actinobacteria	201174|Actinobacteria	I	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF1697
REGS3_k127_5285172_12	1313172.YM304_23660	1.317e-57	210.0	COG0299@1|root,COG0299@2|Bacteria,2H8QB@201174|Actinobacteria,4CNS4@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	purN	-	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	Formyl_trans_N
REGS3_k127_5285172_1	1313172.YM304_23680	3.76e-234	747.0	COG0150@1|root,COG0151@1|root,COG0150@2|Bacteria,COG0151@2|Bacteria,2I2F5@201174|Actinobacteria,4CMZB@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Phosphoribosylglycinamide synthetase, C domain	purD	-	6.3.3.1,6.3.4.13	ko:K01945,ko:K11788	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144,R04208	RC00090,RC00166,RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
REGS3_k127_5285172_19	1313172.YM304_23690	7.452e-07	50.0	COG0034@1|root,COG0034@2|Bacteria,2GK6I@201174|Actinobacteria,4CMWP@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_7,Pribosyltran
REGS3_k127_5316504_26	469383.Cwoe_4230	3.724e-20	91.0	COG1171@1|root,COG1171@2|Bacteria,2GJAG@201174|Actinobacteria,4CS00@84995|Rubrobacteria	84995|Rubrobacteria	E	Pyridoxal-phosphate dependent enzyme	-	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
REGS3_k127_5316504_24	1079986.JH164851_gene1271	2.219e-51	194.0	COG2071@1|root,COG2071@2|Bacteria,2HRHB@201174|Actinobacteria	201174|Actinobacteria	S	peptidase C26	-	-	-	ko:K07010	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_C26
REGS3_k127_5316504_5	1313172.YM304_04190	5.486e-183	588.0	COG1007@1|root,COG1007@2|Bacteria,2GMGX@201174|Actinobacteria,4CMT6@84992|Acidimicrobiia	84992|Acidimicrobiia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
REGS3_k127_5316504_3	1313172.YM304_04180	3.802e-249	779.0	COG1008@1|root,COG1008@2|Bacteria,2GKBN@201174|Actinobacteria,4CMUB@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Protein synonym NADH dehydrogenase I subunit M	-	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
REGS3_k127_5316504_1	1313172.YM304_04170	1.251e-260	816.0	COG1009@1|root,COG1009@2|Bacteria,2GIT4@201174|Actinobacteria,4CMPU@84992|Acidimicrobiia	84992|Acidimicrobiia	CP	protein synonym multiple resistance and pH homeostasis protein A	-	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
REGS3_k127_5316504_25	525909.Afer_0373	4.862e-33	131.0	COG0713@1|root,COG0713@2|Bacteria,2IKV7@201174|Actinobacteria,4CN4N@84992|Acidimicrobiia	84992|Acidimicrobiia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK	-	1.6.5.3	ko:K00340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
REGS3_k127_5316504_23	1313172.YM304_04150	9.434e-53	194.0	COG0839@1|root,COG0839@2|Bacteria,2GKRS@201174|Actinobacteria,4CN8Y@84992|Acidimicrobiia	84992|Acidimicrobiia	C	NADH-ubiquinone/plastoquinone oxidoreductase chain 6	-	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
REGS3_k127_5316504_13	1313172.YM304_04140	1.856e-109	368.0	COG1143@1|root,COG1143@2|Bacteria,2GJNU@201174|Actinobacteria,4CMPP@84992|Acidimicrobiia	84992|Acidimicrobiia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4
REGS3_k127_5316504_7	1313172.YM304_04130	2.018e-157	507.0	COG1005@1|root,COG1005@2|Bacteria,2GIVY@201174|Actinobacteria,4CMTV@84992|Acidimicrobiia	84992|Acidimicrobiia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	-	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
REGS3_k127_5316504_0	1313172.YM304_04120	0.0	1030.0	COG1034@1|root,COG1034@2|Bacteria,2GJGX@201174|Actinobacteria,4CMPH@84992|Acidimicrobiia	84992|Acidimicrobiia	C	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region	-	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdop_Fe4S4,Molybdopterin,NADH-G_4Fe-4S_3
REGS3_k127_5316504_2	1313172.YM304_04110	4.839e-253	788.0	COG1894@1|root,COG1894@2|Bacteria,2GMMC@201174|Actinobacteria,4CMQ2@84992|Acidimicrobiia	84992|Acidimicrobiia	C	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region	-	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S
REGS3_k127_5316504_16	1313172.YM304_04100	7.386e-91	302.0	COG1905@1|root,COG1905@2|Bacteria,2GKG0@201174|Actinobacteria,4CN1U@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Thioredoxin-like [2Fe-2S] ferredoxin	nuoE	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
REGS3_k127_5316504_4	1313172.YM304_04090	1.981e-239	745.0	COG0649@1|root,COG0649@2|Bacteria,2GKEZ@201174|Actinobacteria,4CMP9@84992|Acidimicrobiia	84992|Acidimicrobiia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
REGS3_k127_5316504_21	1313172.YM304_04080	1.553e-63	222.0	COG0852@1|root,COG0852@2|Bacteria,2GIRH@201174|Actinobacteria,4CN4G@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Respiratory-chain NADH dehydrogenase, 30 Kd subunit	-	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
REGS3_k127_5316504_14	1313172.YM304_04070	5.805e-103	340.0	COG0377@1|root,COG0377@2|Bacteria,2GJXR@201174|Actinobacteria,4CMXA@84992|Acidimicrobiia	84992|Acidimicrobiia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
REGS3_k127_5316504_20	1313172.YM304_04060	6.006e-64	222.0	COG0838@1|root,COG0838@2|Bacteria,2IKWT@201174|Actinobacteria,4CN51@84992|Acidimicrobiia	84992|Acidimicrobiia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	-	-	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
REGS3_k127_5316504_17	1313172.YM304_04050	5.217e-73	257.0	2FE68@1|root,34663@2|Bacteria,2H83B@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_5316504_10	1313172.YM304_04040	3.346e-140	453.0	COG2010@1|root,COG2010@2|Bacteria,2H49G@201174|Actinobacteria	201174|Actinobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
REGS3_k127_5316504_15	1313172.YM304_04030	7.736e-99	330.0	COG0723@1|root,COG0723@2|Bacteria	2|Bacteria	C	oxidoreductase activity, acting on diphenols and related substances as donors	-	-	1.10.9.1	ko:K02636,ko:K03886	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00151,M00162	R03817,R08409	RC01002	ko00000,ko00001,ko00002,ko00194,ko01000	-	-	-	Rieske
REGS3_k127_5316504_12	1313172.YM304_04020	2.751e-123	398.0	COG1290@1|root,COG1290@2|Bacteria,2H1Y8@201174|Actinobacteria	201174|Actinobacteria	C	Cytochrome b(C-terminal)/b6/petD	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_B_C
REGS3_k127_5316504_8	1313172.YM304_04010	4.39e-152	482.0	COG1290@1|root,COG1290@2|Bacteria,2GJ1E@201174|Actinobacteria,4CN9T@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Cytochrome b/b6/petB	-	-	-	ko:K03891	ko00190,ko01100,map00190,map01100	M00151	-	-	ko00000,ko00001,ko00002	-	-	-	Cytochrom_B_N_2
REGS3_k127_5316504_18	1313172.YM304_04000	3.955e-71	241.0	COG1143@1|root,COG1143@2|Bacteria,2H4NQ@201174|Actinobacteria	201174|Actinobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_10
REGS3_k127_5316504_22	1313172.YM304_03990	1.896e-60	216.0	2C3UQ@1|root,341WW@2|Bacteria,2H6NT@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_5316504_19	1313172.YM304_03980	5.986e-67	237.0	COG2010@1|root,COG2010@2|Bacteria,2H5KX@201174|Actinobacteria	201174|Actinobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_5316504_6	1229780.BN381_450016	2.395e-164	533.0	COG0644@1|root,COG0644@2|Bacteria,2GKGH@201174|Actinobacteria,3UX9K@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	FAD binding domain	menJ	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016491,GO:0016627,GO:0030312,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901576,GO:1901661,GO:1901663	1.3.99.38	ko:K21401	-	-	-	-	ko00000,ko01000	-	-	-	FAD_binding_3
REGS3_k127_5316504_11	1313172.YM304_03920	5.87e-130	422.0	COG0142@1|root,COG0142@2|Bacteria,2GMB4@201174|Actinobacteria,4CMZ7@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Polyprenyl synthetase	-	-	2.5.1.30	ko:K00805	ko00900,ko01110,map00900,map01110	-	R09247	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
REGS3_k127_5316504_9	1313172.YM304_36940	4.905e-145	466.0	COG0542@1|root,COG0542@2|Bacteria,2GJ77@201174|Actinobacteria,4CMPF@84992|Acidimicrobiia	84992|Acidimicrobiia	O	C-terminal, D2-small domain, of ClpB protein	-	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
REGS3_k127_5337425_24	1035308.AQYY01000001_gene3642	2.271e-25	108.0	COG1180@1|root,COG1180@2|Bacteria,1TPK2@1239|Firmicutes,24871@186801|Clostridia	186801|Clostridia	C	glycyl-radical enzyme activating protein family	yjjW	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4,Fer4_12,Fer4_6,Radical_SAM
REGS3_k127_5337425_2	1313172.YM304_41470	1.525e-189	600.0	COG0644@1|root,COG0644@2|Bacteria,2GKGH@201174|Actinobacteria,4CMZY@84992|Acidimicrobiia	84992|Acidimicrobiia	C	FAD binding domain	-	-	1.3.99.38	ko:K21401	-	-	-	-	ko00000,ko01000	-	-	-	FAD_binding_3
REGS3_k127_5337425_28	1298863.AUEP01000005_gene2436	2.684e-07	59.0	COG2318@1|root,COG2318@2|Bacteria,2II1I@201174|Actinobacteria,4DR3V@85009|Propionibacteriales	201174|Actinobacteria	S	Protein of unknown function (DUF664)	-	-	-	-	-	-	-	-	-	-	-	-	DUF664,DinB_2
REGS3_k127_5337425_0	1429916.X566_16590	9.766e-273	860.0	COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,2TTXG@28211|Alphaproteobacteria,3JVJZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
REGS3_k127_5337425_17	1313172.YM304_35350	2.734e-59	214.0	COG1028@1|root,COG1028@2|Bacteria	1313172.YM304_35350|-	IQ	oxidoreductase activity, acting on CH-OH group of donors	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	-
REGS3_k127_5337425_20	1298863.AUEP01000002_gene1554	3.321e-34	139.0	COG1309@1|root,COG1309@2|Bacteria,2IEU9@201174|Actinobacteria,4DW3K@85009|Propionibacteriales	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
REGS3_k127_5337425_23	1463936.JOJI01000017_gene7396	1.23e-28	124.0	COG1028@1|root,COG1028@2|Bacteria,2GJ0E@201174|Actinobacteria	201174|Actinobacteria	IQ	Dehydrogenases with different specificities (Related to short-chain alcohol dehydrogenases)	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
REGS3_k127_5337425_12	1333998.M2A_2494	1.097e-96	329.0	2EXDM@1|root,33QQ7@2|Bacteria,1NTQ6@1224|Proteobacteria,2UQVJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_5337425_10	1156935.QWE_16663	9.411e-114	376.0	COG2084@1|root,COG2084@2|Bacteria,1MWR4@1224|Proteobacteria,2U157@28211|Alphaproteobacteria,4B7E0@82115|Rhizobiaceae	28211|Alphaproteobacteria	I	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	MA20_20495	-	1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
REGS3_k127_5337425_26	1313172.YM304_28400	4.516e-12	73.0	COG2132@1|root,COG4454@1|root,COG2132@2|Bacteria,COG4454@2|Bacteria,2GMJ4@201174|Actinobacteria	201174|Actinobacteria	Q	Multicopper oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase_2,Cu-oxidase_3,Cupredoxin_1
REGS3_k127_5337425_15	69279.BG36_15765	5.265e-64	228.0	COG4221@1|root,COG4221@2|Bacteria,1MUF8@1224|Proteobacteria,2TR5S@28211|Alphaproteobacteria,43PH7@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
REGS3_k127_5337425_18	765698.Mesci_2583	2.734e-51	190.0	COG1028@1|root,COG1028@2|Bacteria,1QTVR@1224|Proteobacteria,2TT2B@28211|Alphaproteobacteria	28211|Alphaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
REGS3_k127_5337425_11	1150599.MPHLEI_22954	8.356e-98	328.0	COG1234@1|root,COG1234@2|Bacteria,2HV83@201174|Actinobacteria,232BJ@1762|Mycobacteriaceae	201174|Actinobacteria	S	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA	rnz	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
REGS3_k127_5337425_5	1229780.BN381_780010	7.639e-132	433.0	COG0596@1|root,COG0596@2|Bacteria,2GKJB@201174|Actinobacteria	201174|Actinobacteria	EGP	Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons	dhmA	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	3.8.1.5	ko:K01563	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05284,R05367,R05368,R05369,R05370,R07669,R07670	RC01317,RC01340,RC01341,RC02013	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
REGS3_k127_5337425_27	335659.S23_67080	7.863e-09	62.0	2CRBS@1|root,32SNS@2|Bacteria,1RAPW@1224|Proteobacteria,2U90B@28211|Alphaproteobacteria,3JY3I@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
REGS3_k127_5337425_1	402881.Plav_2621	1.654e-209	663.0	COG3119@1|root,COG3119@2|Bacteria,1MV0B@1224|Proteobacteria,2TRI6@28211|Alphaproteobacteria,1JPWF@119043|Rhodobiaceae	28211|Alphaproteobacteria	P	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Choline_sulf_C,DUF4976,Sulfatase
REGS3_k127_5337425_13	1123240.ATVO01000009_gene737	3.11e-91	316.0	2C8FR@1|root,34BJJ@2|Bacteria,1P3IC@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_5337425_22	436229.JOEH01000004_gene412	1.66e-29	122.0	2903B@1|root,2ZMTE@2|Bacteria,2GUB1@201174|Actinobacteria,2NK26@228398|Streptacidiphilus	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_5337425_7	1313172.YM304_19430	5.491e-130	425.0	COG0472@1|root,COG0472@2|Bacteria,2GNEH@201174|Actinobacteria,4CMYF@84992|Acidimicrobiia	84992|Acidimicrobiia	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
REGS3_k127_5337425_16	1229780.BN381_170028	1.561e-63	234.0	COG1403@1|root,COG1403@2|Bacteria	2|Bacteria	V	endonuclease activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
REGS3_k127_5337425_21	258533.BN977_00546	9.958e-33	138.0	COG0454@1|root,COG0456@2|Bacteria,2I9Y3@201174|Actinobacteria,2354F@1762|Mycobacteriaceae	201174|Actinobacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
REGS3_k127_5337425_14	1156844.KB891831_gene4516	3.185e-76	266.0	COG2021@1|root,COG2021@2|Bacteria,2I3NA@201174|Actinobacteria	201174|Actinobacteria	E	Serine aminopeptidase, S33	lipG2	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
REGS3_k127_5337425_19	378806.STAUR_0036	2.031e-41	169.0	COG0477@1|root,COG0477@2|Bacteria,1MXZ3@1224|Proteobacteria,43BMH@68525|delta/epsilon subdivisions	1224|Proteobacteria	EGP	Major facilitator superfamily	MA20_25180	-	-	-	-	-	-	-	-	-	-	-	MFS_3
REGS3_k127_5337425_3	1146883.BLASA_0480	8.963e-169	550.0	COG0747@1|root,COG0747@2|Bacteria,2GMAX@201174|Actinobacteria,4EU9T@85013|Frankiales	201174|Actinobacteria	E	extracellular solute-binding protein, family 5	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
REGS3_k127_5337425_8	1452535.JARD01000018_gene2456	3.127e-122	401.0	COG0601@1|root,COG0601@2|Bacteria,2GJ2C@201174|Actinobacteria,4FKA5@85023|Microbacteriaceae	201174|Actinobacteria	EP	Binding-protein-dependent transport system inner membrane component	dppB	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
REGS3_k127_5337425_9	1032480.MLP_36070	8.738e-121	396.0	COG0444@1|root,COG0444@2|Bacteria,2GIXV@201174|Actinobacteria,4DPCV@85009|Propionibacteriales	201174|Actinobacteria	EP	Belongs to the ABC transporter superfamily	appD	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
REGS3_k127_5337425_6	1122622.ATWJ01000007_gene1488	1.002e-130	431.0	COG4608@1|root,COG4608@2|Bacteria,2H4BW@201174|Actinobacteria,4FEBA@85021|Intrasporangiaceae	201174|Actinobacteria	E	Belongs to the ABC transporter superfamily	-	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
REGS3_k127_5337425_4	1380355.JNIJ01000020_gene3759	4.52e-157	505.0	COG2141@1|root,COG2141@2|Bacteria,1NKS6@1224|Proteobacteria,2TT87@28211|Alphaproteobacteria,3JRJ6@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Luciferase-like monooxygenase	MA20_23445	-	1.14.13.107	ko:K14733	ko00903,map00903	-	R06398,R09385,R09389,R09393	RC01506	ko00000,ko00001,ko01000	-	-	-	Bac_luciferase
REGS3_k127_5350735_1	526225.Gobs_3093	3.014e-126	424.0	COG1640@1|root,COG1640@2|Bacteria,2GM5Z@201174|Actinobacteria,4ERC9@85013|Frankiales	201174|Actinobacteria	G	PFAM glycoside hydrolase family 77	-	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
REGS3_k127_5350735_4	1313172.YM304_21360	7.445e-22	97.0	29B43@1|root,2ZY2Q@2|Bacteria,2HD3P@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_5350735_2	1313172.YM304_21370	1.878e-88	295.0	COG3707@1|root,COG3707@2|Bacteria,2GK7T@201174|Actinobacteria,4CN3I@84992|Acidimicrobiia	84992|Acidimicrobiia	T	ANTAR	-	-	-	ko:K22010	-	M00839	-	-	ko00000,ko00002,ko02022	-	-	-	ANTAR,Response_reg
REGS3_k127_5350735_0	1229780.BN381_80407	6.443e-314	985.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,2GJY2@201174|Actinobacteria,3UWEE@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0030312,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
REGS3_k127_5350735_3	1229780.BN381_100036	5.434e-40	153.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Methyltransf_25,Methyltransf_31
REGS3_k127_535557_2	1313172.YM304_33140	1.772e-166	533.0	COG1694@1|root,COG3956@2|Bacteria,2GNKC@201174|Actinobacteria,4CN31@84992|Acidimicrobiia	84992|Acidimicrobiia	S	MazG nucleotide pyrophosphohydrolase domain	-	-	-	ko:K02499	-	-	-	-	ko00000,ko03036	-	-	-	MazG
REGS3_k127_535557_0	452652.KSE_46630	6.4e-323	1028.0	COG1197@1|root,COG1197@2|Bacteria,2GJ42@201174|Actinobacteria,2M1SK@2063|Kitasatospora	201174|Actinobacteria	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
REGS3_k127_535557_3	263358.VAB18032_20995	1.899e-115	377.0	COG3384@1|root,COG3384@2|Bacteria,2GKTV@201174|Actinobacteria,4DC9P@85008|Micromonosporales	201174|Actinobacteria	S	Extradiol ring-cleavage dioxygenase class III protein subunit B	-	-	-	ko:K15777	ko00965,map00965	-	R08836	RC00387	ko00000,ko00001,ko01000	-	-	-	LigB
REGS3_k127_535557_1	1313172.YM304_09450	6.701e-183	590.0	COG0488@1|root,COG0488@2|Bacteria,2GK9S@201174|Actinobacteria	201174|Actinobacteria	S	ABC transporter	yjjK	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
REGS3_k127_535557_4	1313172.YM304_33110	1.235e-25	108.0	COG0193@1|root,COG0193@2|Bacteria,2GKCV@201174|Actinobacteria,4CN75@84992|Acidimicrobiia	84992|Acidimicrobiia	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	-	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
REGS3_k127_5375555_0	1313172.YM304_10500	1.21e-249	792.0	COG1506@1|root,COG1506@2|Bacteria,2GJ6A@201174|Actinobacteria,4CN38@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Dipeptidyl peptidase IV (DPP IV) N-terminal region	-	-	3.4.14.5	ko:K01278	ko04974,map04974	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	DPPIV_N,Peptidase_S9
REGS3_k127_5375555_1	1297865.APJD01000007_gene2359	2.08e-105	355.0	COG1063@1|root,COG1063@2|Bacteria,1MV9A@1224|Proteobacteria,2TTZZ@28211|Alphaproteobacteria,3JVH5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Alcohol dehydrogenase GroES-like domain	MA20_17025	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
REGS3_k127_5375555_2	1313172.YM304_10510	4.313e-45	166.0	COG1957@1|root,COG1957@2|Bacteria,2GP6N@201174|Actinobacteria	201174|Actinobacteria	F	nucleoside hydrolase	rihB	-	3.2.2.1,3.2.2.8	ko:K01239,ko:K01250,ko:K10213	ko00230,ko00240,ko00760,ko01100,map00230,map00240,map00760,map01100	-	R01245,R01273,R01677,R01770,R02137,R02143	RC00033,RC00063,RC00122,RC00318,RC00485	ko00000,ko00001,ko01000	-	-	-	IU_nuc_hydro
REGS3_k127_5376050_4	1157635.KB892057_gene5129	8.926e-18	94.0	2E37T@1|root,32Y7G@2|Bacteria,2GQH5@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF2752)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2752
REGS3_k127_5376050_0	1313172.YM304_13880	3.209e-250	782.0	COG0488@1|root,COG0488@2|Bacteria,2GKQ4@201174|Actinobacteria,4CNIJ@84992|Acidimicrobiia	84992|Acidimicrobiia	S	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,ABC_tran_Xtn
REGS3_k127_5376050_2	1298863.AUEP01000006_gene3327	1.149e-59	217.0	COG1309@1|root,COG1309@2|Bacteria,2IJ18@201174|Actinobacteria,4DWUE@85009|Propionibacteriales	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
REGS3_k127_5376050_3	1121924.ATWH01000016_gene3084	3.916e-43	161.0	COG4319@1|root,COG4319@2|Bacteria,2I5U3@201174|Actinobacteria	201174|Actinobacteria	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
REGS3_k127_5376050_5	101510.RHA1_ro02774	1.727e-15	83.0	2E8H6@1|root,32DUK@2|Bacteria,2GUZN@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_5376050_1	1211815.CBYP010000022_gene2914	3.242e-127	431.0	COG5001@1|root,COG5001@2|Bacteria,2GIZF@201174|Actinobacteria,4ERVM@85013|Frankiales	201174|Actinobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF
REGS3_k127_5384607_3	1313172.YM304_33030	1.971e-73	251.0	COG0084@1|root,COG0084@2|Bacteria,2GMJJ@201174|Actinobacteria,4CN2X@84992|Acidimicrobiia	84992|Acidimicrobiia	L	TatD related DNase	-	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
REGS3_k127_5384607_1	1313172.YM304_33050	4.382e-96	323.0	COG0030@1|root,COG0030@2|Bacteria,2GKBT@201174|Actinobacteria,4CN5A@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	-	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
REGS3_k127_5384607_2	1313172.YM304_33060	1.781e-87	303.0	COG1947@1|root,COG1947@2|Bacteria,2HG8Y@201174|Actinobacteria,4CN6Y@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	ispE	-	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	-
REGS3_k127_5384607_0	1313172.YM304_33080	5.877e-144	461.0	COG1207@1|root,COG1207@2|Bacteria,2GJS1@201174|Actinobacteria,4CMZA@84992|Acidimicrobiia	84992|Acidimicrobiia	M	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	-	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transf_3
REGS3_k127_5401579_9	1313172.YM304_19210	2.607e-26	109.0	COG0554@1|root,COG0554@2|Bacteria,2GM13@201174|Actinobacteria,4CMTY@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK	-	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
REGS3_k127_5401579_8	1313172.YM304_19200	1.744e-50	190.0	COG0317@1|root,COG0317@2|Bacteria	2|Bacteria	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	sdaAB	-	2.7.6.5,3.1.7.2,4.3.1.17,4.3.1.19	ko:K01139,ko:K01752,ko:K01754	ko00230,ko00260,ko00270,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00230,map00260,map00270,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00336,R00429,R00590,R00996	RC00002,RC00078,RC00331,RC00418,RC02600	ko00000,ko00001,ko00002,ko01000,ko03009	-	-	-	ACT,HD_4,PALP,RelA_SpoT,SDH_beta
REGS3_k127_5401579_0	1313172.YM304_19190	1.194e-225	702.0	COG0436@1|root,COG0436@2|Bacteria,2GJ7R@201174|Actinobacteria,4CNS0@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Aminotransferase class I and II	-	-	-	ko:K14261	-	-	-	-	ko00000,ko01000,ko01007	-	-	-	Aminotran_1_2
REGS3_k127_5401579_5	1313172.YM304_19180	2.058e-81	274.0	COG0221@1|root,COG0221@2|Bacteria,2GM7F@201174|Actinobacteria,4CN6U@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions	ppa	-	3.6.1.1	ko:K01507	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyrophosphatase
REGS3_k127_5401579_4	1313172.YM304_19170	1.459e-95	323.0	COG1940@1|root,COG1940@2|Bacteria,2GJA0@201174|Actinobacteria,4CNH1@84992|Acidimicrobiia	201174|Actinobacteria	G	ROK family	ppgK	-	2.7.1.2,2.7.1.63	ko:K00845,ko:K00886	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786,R02187,R02189	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
REGS3_k127_5401579_7	1313172.YM304_19160	3.409e-57	202.0	COG2867@1|root,COG2867@2|Bacteria,2IFH4@201174|Actinobacteria,4CN9D@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc
REGS3_k127_5401579_10	1229780.BN381_140041	1.283e-06	58.0	28Z2K@1|root,2ZKV3@2|Bacteria,2HA4X@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_5401579_2	1313172.YM304_19140	2.401e-171	546.0	COG0438@1|root,COG0438@2|Bacteria,2GM6D@201174|Actinobacteria,4CN28@84992|Acidimicrobiia	84992|Acidimicrobiia	M	Glycosyl transferases group 1	-	-	2.4.1.346	ko:K13668	-	-	R11703,R11704	-	ko00000,ko01000,ko01003	-	GT4	-	Glyco_transf_4,Glycos_transf_1
REGS3_k127_5401579_3	1313172.YM304_19130	2.771e-108	374.0	COG1600@1|root,COG1600@2|Bacteria,2HGVB@201174|Actinobacteria,4CNW5@84992|Acidimicrobiia	84992|Acidimicrobiia	C	4Fe-4S double cluster binding domain	-	-	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Fer4_16
REGS3_k127_5401579_11	287986.DV20_17935	0.0006036	50.0	2EGHN@1|root,33A9R@2|Bacteria,2GSZ1@201174|Actinobacteria,4E7HS@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_5401579_6	1313172.YM304_19100	1.635e-66	246.0	COG3688@1|root,COG3688@2|Bacteria,2GR19@201174|Actinobacteria	201174|Actinobacteria	M	RNA-binding protein containing a PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN_YacP
REGS3_k127_5401579_1	1313172.YM304_19090	1.192e-184	588.0	COG0322@1|root,COG2176@1|root,COG0322@2|Bacteria,COG2176@2|Bacteria,2GMC0@201174|Actinobacteria,4CN4W@84992|Acidimicrobiia	84992|Acidimicrobiia	L	EXOIII	-	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
REGS3_k127_5403615_6	298655.KI912266_gene6118	1.165e-24	104.0	COG2159@1|root,COG2159@2|Bacteria,2GKG2@201174|Actinobacteria,4EUWU@85013|Frankiales	201174|Actinobacteria	S	PFAM Amidohydrolase 2	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
REGS3_k127_5403615_1	298653.Franean1_4324	1.232e-140	457.0	COG2124@1|root,COG2124@2|Bacteria,2GJ8V@201174|Actinobacteria	201174|Actinobacteria	Q	cytochrome p450	-	-	-	-	-	-	-	-	-	-	-	-	p450
REGS3_k127_5403615_5	298655.KI912267_gene6905	1.197e-31	134.0	COG1309@1|root,COG1309@2|Bacteria,2ICIZ@201174|Actinobacteria	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
REGS3_k127_5403615_0	298654.FraEuI1c_4314	1.13e-255	799.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria	201174|Actinobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.48	ko:K02182	-	-	-	-	ko00000,ko01000	-	-	-	AMP-binding,AMP-binding_C
REGS3_k127_5403615_3	326424.FRAAL3422	1.356e-125	408.0	COG1028@1|root,COG1028@2|Bacteria,2GN6U@201174|Actinobacteria	201174|Actinobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short,adh_short_C2
REGS3_k127_5403615_4	1229780.BN381_510008	6.829e-120	397.0	COG1960@1|root,COG1960@2|Bacteria,2GJDT@201174|Actinobacteria	201174|Actinobacteria	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
REGS3_k127_5403615_7	345341.KUTG_02825	0.0002803	51.0	COG0346@1|root,COG0346@2|Bacteria,2IHM7@201174|Actinobacteria	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase,Glyoxalase_4
REGS3_k127_5403615_2	1380356.JNIK01000017_gene2842	1.492e-137	448.0	COG0318@1|root,COG0318@2|Bacteria,2IBED@201174|Actinobacteria,4EU08@85013|Frankiales	201174|Actinobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
REGS3_k127_544874_2	1313172.YM304_07880	2.376e-100	329.0	COG0250@1|root,COG0250@2|Bacteria,2GJFW@201174|Actinobacteria,4CMZG@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Participates in transcription elongation, termination and antitermination	nusG	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusG
REGS3_k127_544874_9	1229780.BN381_350060	1.1e-57	203.0	COG0080@1|root,COG0080@2|Bacteria,2IFCK@201174|Actinobacteria,3UWIZ@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rplK	-	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
REGS3_k127_544874_3	1313172.YM304_07900	2.774e-99	329.0	COG0081@1|root,COG0081@2|Bacteria,2GM51@201174|Actinobacteria,4CMU4@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	-	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
REGS3_k127_544874_8	1313172.YM304_07930	5.567e-58	206.0	COG0244@1|root,COG0244@2|Bacteria,2GM0V@201174|Actinobacteria,4CN6B@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rplJ	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
REGS3_k127_544874_10	1184609.KILIM_003_01020	1.387e-42	159.0	COG0222@1|root,COG0222@2|Bacteria,2IKNW@201174|Actinobacteria,4F6ZG@85018|Dermatophilaceae	201174|Actinobacteria	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation	rplL	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K02935	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L12,Ribosomal_L12_N
REGS3_k127_544874_11	350058.Mvan_5851	3.329e-08	63.0	2EB70@1|root,3357M@2|Bacteria,2I9PW@201174|Actinobacteria,237JT@1762|Mycobacteriaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_544874_4	177439.DP0005	9.152e-95	317.0	COG0106@1|root,COG0106@2|Bacteria,1R6J2@1224|Proteobacteria,43B0N@68525|delta/epsilon subdivisions,2X6EQ@28221|Deltaproteobacteria,2MICV@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Belongs to the HisA HisF family	-	-	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
REGS3_k127_544874_1	1313172.YM304_08000	0.0	2093.0	COG0085@1|root,COG0085@2|Bacteria,2GJ81@201174|Actinobacteria,4CMVP@84992|Acidimicrobiia	84992|Acidimicrobiia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
REGS3_k127_544874_0	1313172.YM304_08010	0.0	2170.0	COG0086@1|root,COG0086@2|Bacteria,2GKWF@201174|Actinobacteria,4CMT4@84992|Acidimicrobiia	84992|Acidimicrobiia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
REGS3_k127_544874_6	251221.35214922	1.352e-66	237.0	COG1028@1|root,COG1028@2|Bacteria,1G47E@1117|Cyanobacteria	1117|Cyanobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
REGS3_k127_544874_7	1313172.YM304_08090	9.881e-65	222.0	COG0048@1|root,COG0048@2|Bacteria,2IHUF@201174|Actinobacteria,4CN6J@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit	rpsL	-	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
REGS3_k127_544874_5	1229780.BN381_180002	1.111e-70	241.0	COG0049@1|root,COG0049@2|Bacteria,2GMVW@201174|Actinobacteria,3UWK1@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA	rpsG	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
REGS3_k127_5470300_2	1229780.BN381_250080	9.189e-198	632.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,2GK8E@201174|Actinobacteria,3UWJK@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	NADH:flavin oxidoreductase / NADH oxidase family	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN,Pyr_redox_2
REGS3_k127_5470300_8	1313172.YM304_35160	1.539e-49	183.0	COG0344@1|root,COG0344@2|Bacteria,2IF8Y@201174|Actinobacteria	201174|Actinobacteria	I	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP	plsY	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
REGS3_k127_5470300_1	1313172.YM304_35130	1.584e-201	631.0	COG0535@1|root,COG0535@2|Bacteria,2GNSY@201174|Actinobacteria,4CNN3@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Iron-sulfur cluster-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM,SPASM
REGS3_k127_5470300_9	1313172.YM304_35120	2.472e-25	109.0	COG0535@1|root,COG0535@2|Bacteria,2GQQT@201174|Actinobacteria	201174|Actinobacteria	S	Mycofactocin system	mftB	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_5470300_7	266117.Rxyl_0591	1.44e-52	193.0	COG3415@1|root,COG3415@2|Bacteria,2I3JK@201174|Actinobacteria	201174|Actinobacteria	L	Protein of unknown function (DUF3105)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3105
REGS3_k127_5470300_0	1313172.YM304_20540	2.445e-239	757.0	COG3973@1|root,COG3973@2|Bacteria,2GK30@201174|Actinobacteria,4CMUM@84992|Acidimicrobiia	201174|Actinobacteria	L	AAA domain	helD	-	-	-	-	-	-	-	-	-	-	-	AAA_19,UvrD_C_2
REGS3_k127_5470300_3	1313172.YM304_35030	3.883e-195	613.0	COG1062@1|root,COG1062@2|Bacteria,2GM8C@201174|Actinobacteria,4CNIH@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.1,1.1.1.284	ko:K00121	ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
REGS3_k127_5470300_4	1313172.YM304_34990	1.055e-190	601.0	COG1062@1|root,COG1062@2|Bacteria,2GM8C@201174|Actinobacteria	201174|Actinobacteria	C	alcohol dehydrogenase	-	-	1.1.1.1,1.1.1.284	ko:K00121	ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
REGS3_k127_5470300_5	1313172.YM304_34980	7.779e-126	409.0	COG0714@1|root,COG0714@2|Bacteria,2GMBP@201174|Actinobacteria	201174|Actinobacteria	S	PFAM ATPase associated with various cellular activities, AAA_5	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_5,VWA_CoxE
REGS3_k127_5470300_6	1313172.YM304_34970	2.509e-117	385.0	COG2304@1|root,COG2304@2|Bacteria,2I959@201174|Actinobacteria	201174|Actinobacteria	S	von Willebrand factor type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA,VWA_2,VWA_CoxE
REGS3_k127_5470300_10	298654.FraEuI1c_5878	1.398e-13	74.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
REGS3_k127_5470418_1	760192.Halhy_0465	3.287e-156	499.0	COG0620@1|root,COG0620@2|Bacteria,4NJAH@976|Bacteroidetes,1IZXY@117747|Sphingobacteriia	976|Bacteroidetes	E	COGs COG0620 Methionine synthase II (cobalamin-independent)	-	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
REGS3_k127_5470418_3	1121033.AUCF01000026_gene2985	3.869e-127	413.0	COG3384@1|root,COG3384@2|Bacteria,1MW77@1224|Proteobacteria,2TRP1@28211|Alphaproteobacteria,2JVBN@204441|Rhodospirillales	204441|Rhodospirillales	S	Catalytic LigB subunit of aromatic ring-opening dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	LigA,LigB
REGS3_k127_5470418_13	1121033.AUCF01000026_gene2984	1.733e-41	166.0	COG2084@1|root,COG3384@1|root,COG2084@2|Bacteria,COG3384@2|Bacteria,1MX8V@1224|Proteobacteria,2TVBS@28211|Alphaproteobacteria,2JTAE@204441|Rhodospirillales	204441|Rhodospirillales	I	Domain of unknown function (DUF1932)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1932,NAD_binding_2
REGS3_k127_5470418_0	391937.NA2_00805	1.934e-165	536.0	COG0654@1|root,COG0654@2|Bacteria,1MV8T@1224|Proteobacteria,2TRB8@28211|Alphaproteobacteria,43GRK@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	CH	4-hydroxybenzoate 3-monooxygenase	pobA	-	1.14.13.2	ko:K00481	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R01298	RC00046	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3
REGS3_k127_5470418_9	471857.Svir_38400	3.048e-81	278.0	COG0684@1|root,COG0684@2|Bacteria,2I8VQ@201174|Actinobacteria,4E6BF@85010|Pseudonocardiales	201174|Actinobacteria	H	Aldolase/RraA	ligK	-	4.1.3.17	ko:K10218	ko00362,ko00660,ko01120,map00362,map00660,map01120	-	R00008,R00350	RC00067,RC00502,RC01205	ko00000,ko00001,ko01000	-	-	-	RraA-like
REGS3_k127_5470418_8	566466.NOR53_932	2.794e-91	308.0	COG2084@1|root,COG2084@2|Bacteria,1MX8V@1224|Proteobacteria,1RW94@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases	-	-	-	-	-	-	-	-	-	-	-	-	DUF1932,NAD_binding_2
REGS3_k127_5470418_11	1394178.AWOO02000027_gene5246	1.679e-46	175.0	COG1802@1|root,COG1802@2|Bacteria,2IBT4@201174|Actinobacteria,4EP8P@85012|Streptosporangiales	201174|Actinobacteria	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
REGS3_k127_5470418_4	298655.KI912266_gene5727	8.217e-119	387.0	COG1024@1|root,COG1024@2|Bacteria	2|Bacteria	I	Enoyl-CoA hydratase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
REGS3_k127_5470418_7	298655.KI912266_gene5761	5.637e-97	324.0	COG1024@1|root,COG1024@2|Bacteria,2IDF4@201174|Actinobacteria,4EX6Y@85013|Frankiales	201174|Actinobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	5.3.3.18	ko:K15866	ko00360,ko01120,map00360,map01120	-	R09837,R09839	RC00004,RC00326,RC02689,RC03003	ko00000,ko00001,ko01000	-	-	-	ECH_1
REGS3_k127_5470418_6	1380356.JNIK01000003_gene1294	8.118e-100	344.0	COG1024@1|root,COG1024@2|Bacteria,2GJY4@201174|Actinobacteria,4EU9Q@85013|Frankiales	201174|Actinobacteria	I	enoyl-CoA hydratase isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
REGS3_k127_5470418_2	2002.JOEQ01000015_gene5076	2.017e-129	417.0	COG1024@1|root,COG1024@2|Bacteria,2GJY4@201174|Actinobacteria,4EK30@85012|Streptosporangiales	201174|Actinobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
REGS3_k127_5470418_12	1265310.CCBD010000015_gene3714	7.287e-46	178.0	COG4221@1|root,COG4221@2|Bacteria,2IFSP@201174|Actinobacteria,23966@1762|Mycobacteriaceae	201174|Actinobacteria	S	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
REGS3_k127_5470418_10	292459.STH1875	5.675e-72	252.0	COG1028@1|root,COG1028@2|Bacteria,1TSJI@1239|Firmicutes,24EFJ@186801|Clostridia	186801|Clostridia	IQ	Short chain dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
REGS3_k127_5470418_15	319003.Bra1253DRAFT_00172	2.735e-15	78.0	2DRQB@1|root,33CKR@2|Bacteria,1MZI3@1224|Proteobacteria,2UDVN@28211|Alphaproteobacteria,3K512@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_5470418_14	395492.Rleg2_4285	1.094e-18	94.0	COG1846@1|root,COG1846@2|Bacteria,1RFUJ@1224|Proteobacteria,2U84N@28211|Alphaproteobacteria,4BENY@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	transcriptional regulator	pecS	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
REGS3_k127_5470418_5	1449976.KALB_2441	9.008e-117	386.0	COG0673@1|root,COG0673@2|Bacteria,2GKW0@201174|Actinobacteria,4E07A@85010|Pseudonocardiales	201174|Actinobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
REGS3_k127_5491072_14	1313172.YM304_25000	5.686e-82	278.0	COG0128@1|root,COG0128@2|Bacteria,2GJKX@201174|Actinobacteria,4CNB2@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
REGS3_k127_5491072_20	1313172.YM304_25010	1.067e-48	182.0	COG0560@1|root,COG0560@2|Bacteria,2GTHF@201174|Actinobacteria	201174|Actinobacteria	E	haloacid dehalogenase-like hydrolase	-	-	3.1.3.27	ko:K18697	ko00564,map00564	-	R02029	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD
REGS3_k127_5491072_12	1313172.YM304_25020	2.018e-95	321.0	COG0382@1|root,COG0382@2|Bacteria,2GJ6P@201174|Actinobacteria,4CNR9@84992|Acidimicrobiia	84992|Acidimicrobiia	H	UbiA prenyltransferase family	-	-	2.4.2.45	ko:K14136	-	-	R10095	RC00005	ko00000,ko01000,ko01006	-	-	-	UbiA
REGS3_k127_5491072_11	1313172.YM304_25030	8.021e-97	325.0	COG4122@1|root,COG4122@2|Bacteria,2GQ0Z@201174|Actinobacteria	201174|Actinobacteria	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_24
REGS3_k127_5491072_4	1120950.KB892742_gene3045	3.452e-151	496.0	COG0277@1|root,COG0277@2|Bacteria,2HZ5X@201174|Actinobacteria,4DNVZ@85009|Propionibacteriales	201174|Actinobacteria	C	D-arabinono-1,4-lactone oxidase	-	-	1.1.98.3	ko:K16653	-	-	-	-	ko00000,ko01000	-	-	-	ALO,FAD_binding_4
REGS3_k127_5491072_18	1449355.JQNR01000005_gene3819	1.738e-64	231.0	COG0300@1|root,COG0300@2|Bacteria,2GNPI@201174|Actinobacteria	201174|Actinobacteria	S	Dehydrogenases with different specificities (Related to short-chain alcohol dehydrogenases)	phbB	-	1.1.1.333	ko:K16652	-	-	-	-	ko00000,ko01000	-	-	-	adh_short
REGS3_k127_5491072_2	1313172.YM304_25080	4.614e-166	544.0	2EW2W@1|root,33PG5@2|Bacteria,2H27S@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_5491072_5	1313172.YM304_25090	4.642e-150	484.0	COG0438@1|root,COG0438@2|Bacteria,2GK8D@201174|Actinobacteria	201174|Actinobacteria	M	Glycosyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
REGS3_k127_5491072_7	1313172.YM304_25140	1.921e-142	475.0	28TMQ@1|root,33S62@2|Bacteria,2H3TK@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_5491072_16	935866.JAER01000003_gene1311	2.947e-76	266.0	COG0500@1|root,COG2226@2|Bacteria,2HEFM@201174|Actinobacteria	201174|Actinobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
REGS3_k127_5491072_22	1089553.Tph_c14180	9.258e-27	125.0	COG1807@1|root,COG1807@2|Bacteria,1V1HJ@1239|Firmicutes,249BG@186801|Clostridia,42HAV@68295|Thermoanaerobacterales	186801|Clostridia	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
REGS3_k127_5491072_21	656024.FsymDg_0458	1.659e-33	148.0	COG1287@1|root,COG1287@2|Bacteria,2HBRT@201174|Actinobacteria,4EXCN@85013|Frankiales	201174|Actinobacteria	S	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_5491072_19	1229780.BN381_150001	5.604e-57	215.0	COG1807@1|root,COG1807@2|Bacteria,2IITJ@201174|Actinobacteria	2|Bacteria	M	Evidence 5 No homology to any previously reported sequences	-	-	-	ko:K14340	-	-	-	-	ko00000,ko01000,ko01003	-	-	-	PMT_2
REGS3_k127_5491072_6	1313172.YM304_29790	1.168e-145	490.0	COG1835@1|root,COG2845@1|root,COG1835@2|Bacteria,COG2845@2|Bacteria,2GKI5@201174|Actinobacteria,4CNC6@84992|Acidimicrobiia	201174|Actinobacteria	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
REGS3_k127_5491072_3	1313172.YM304_25230	4.08e-156	499.0	COG0451@1|root,COG0451@2|Bacteria,2GMHH@201174|Actinobacteria	201174|Actinobacteria	M	3-beta hydroxysteroid dehydrogenase isomerase	-	-	-	ko:K21793	ko00333,ko01130,map00333,map01130	M00838	R11663,R11666	-	ko00000,ko00001,ko00002	-	-	-	Epimerase
REGS3_k127_5491072_9	1313172.YM304_25240	1.211e-111	371.0	COG0451@1|root,COG0451@2|Bacteria	2|Bacteria	GM	ADP-glyceromanno-heptose 6-epimerase activity	JD73_00815	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
REGS3_k127_5491072_1	1313172.YM304_25250	1.103e-194	621.0	COG2303@1|root,COG2303@2|Bacteria,2GJKS@201174|Actinobacteria	201174|Actinobacteria	E	Oxidoreductase	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N,Gluconate_2-dh3
REGS3_k127_5491072_15	1089546.AQUI01000002_gene217	1.114e-76	282.0	COG1835@1|root,COG1835@2|Bacteria,2GKI5@201174|Actinobacteria	201174|Actinobacteria	I	Acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
REGS3_k127_5491072_10	1229780.BN381_110033	8.937e-101	336.0	COG1215@1|root,COG1215@2|Bacteria,2GP1D@201174|Actinobacteria	201174|Actinobacteria	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
REGS3_k127_5491072_0	1313172.YM304_25220	0.0	1132.0	COG1807@1|root,COG1807@2|Bacteria,2I5WT@201174|Actinobacteria	201174|Actinobacteria	M	Domain of unknown function (DUF3367)	-	-	-	ko:K16648	-	-	-	-	ko00000,ko01000,ko01003	-	-	-	DUF3367
REGS3_k127_5491072_13	1313172.YM304_25130	2.489e-91	307.0	COG0463@1|root,COG0463@2|Bacteria,2IPT1@201174|Actinobacteria	201174|Actinobacteria	M	PFAM Glycosyl transferase family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
REGS3_k127_5491072_8	1313172.YM304_25280	1.372e-119	398.0	COG5542@1|root,COG5542@2|Bacteria,2GJQF@201174|Actinobacteria	201174|Actinobacteria	NT	integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	Mannosyl_trans2,PMT_2
REGS3_k127_5491072_17	1313172.YM304_25290	6.226e-70	241.0	COG0122@1|root,COG0122@2|Bacteria,2GP69@201174|Actinobacteria	201174|Actinobacteria	L	3-methyladenine DNA glycosylase	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_5499009_0	1313172.YM304_15700	9.885e-251	788.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4CMUG@84992|Acidimicrobiia	201174|Actinobacteria	IQ	Protein synonym acyl-CoA synthetase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
REGS3_k127_5499009_1	1313172.YM304_15670	9.04e-158	503.0	COG2124@1|root,COG2124@2|Bacteria,2GJ8V@201174|Actinobacteria	201174|Actinobacteria	Q	cytochrome p450	-	-	1.14.13.221	ko:K16046	ko00984,ko01120,map00984,map01120	-	R09859,R11361	RC01216,RC03368	ko00000,ko00001,ko00199,ko01000	-	-	-	p450
REGS3_k127_555158_1	1313172.YM304_35250	1.125e-158	503.0	COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,2GM09@201174|Actinobacteria,4CMTF@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Catalyzes the synthesis of GMP from XMP	guaA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
REGS3_k127_555158_7	1313172.YM304_35230	3.925e-70	252.0	COG0791@1|root,COG1196@1|root,COG0791@2|Bacteria,COG1196@2|Bacteria,2GIWB@201174|Actinobacteria,4CNAP@84992|Acidimicrobiia	84992|Acidimicrobiia	M	NlpC/P60 family	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	NLPC_P60,SLT
REGS3_k127_555158_2	1313172.YM304_35210	1.139e-140	456.0	COG3173@1|root,COG3173@2|Bacteria,2GJT0@201174|Actinobacteria,4CNSV@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
REGS3_k127_555158_4	1313172.YM304_35200	7.482e-113	373.0	COG0412@1|root,COG0412@2|Bacteria,2GK7H@201174|Actinobacteria	201174|Actinobacteria	Q	dienelactone hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	DLH
REGS3_k127_555158_0	1313172.YM304_35190	2.374e-244	765.0	COG0318@1|root,COG0318@2|Bacteria,2GJA2@201174|Actinobacteria	201174|Actinobacteria	IQ	synthetase	-	-	6.2.1.42	ko:K18688	-	-	-	-	ko00000,ko01000	-	-	-	AMP-binding,AMP-binding_C
REGS3_k127_555158_6	1120934.KB894404_gene625	2.007e-79	276.0	COG1741@1|root,COG1741@2|Bacteria,2GJV3@201174|Actinobacteria,4E1JD@85010|Pseudonocardiales	201174|Actinobacteria	S	Pirin	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin
REGS3_k127_555158_3	1313172.YM304_35170	1.959e-113	370.0	COG1028@1|root,COG1028@2|Bacteria,2GJU1@201174|Actinobacteria	201174|Actinobacteria	IQ	Short-chain dehydrogenase reductase sdr	-	-	1.1.1.127	ko:K00065	ko00040,map00040	-	R01542	RC00089	ko00000,ko00001,ko01000	-	-	-	adh_short_C2
REGS3_k127_555158_8	1944.JOAZ01000023_gene2556	3.337e-65	233.0	COG0842@1|root,COG0842@2|Bacteria,2I9MM@201174|Actinobacteria	201174|Actinobacteria	V	ABC-2 type transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane
REGS3_k127_555158_5	1463936.JOJI01000001_gene1859	9.942e-84	285.0	COG1131@1|root,COG1131@2|Bacteria,2IE14@201174|Actinobacteria	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
REGS3_k127_555158_9	994479.GL877879_gene5209	1.197e-18	87.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,2GMB6@201174|Actinobacteria,4E27M@85010|Pseudonocardiales	201174|Actinobacteria	C	NADH:flavin oxidoreductase / NADH oxidase family	-	-	1.3.1.34	ko:K00219	-	-	-	-	ko00000,ko01000	-	-	-	NAD_binding_8,Oxidored_FMN,Pyr_redox,Pyr_redox_2
REGS3_k127_5555054_5	1120746.CCNL01000017_gene2658	1.821e-06	61.0	COG2247@1|root,COG3386@1|root,COG3468@1|root,COG3540@1|root,COG2247@2|Bacteria,COG3386@2|Bacteria,COG3468@2|Bacteria,COG3540@2|Bacteria	2|Bacteria	P	PhoD-like phosphatase	-	-	-	ko:K14274,ko:K14645,ko:K20276	ko00040,ko02024,map00040,map02024	-	R02427	RC00713	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	CarboxypepD_reg,DUF5122,He_PIG,NHL,SGL,TIG
REGS3_k127_5555054_1	671143.DAMO_2906	3.729e-147	477.0	COG2132@1|root,COG2132@2|Bacteria	2|Bacteria	Q	Multicopper oxidase	-	-	1.16.3.3,1.7.2.1	ko:K00368,ko:K22348	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000	-	-	-	Copper-bind,Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3,SdrD_B,TIG,fn3_3
REGS3_k127_5555054_4	118166.JH976537_gene4334	2.363e-10	68.0	COG1357@1|root,COG1714@1|root,COG1357@2|Bacteria,COG1714@2|Bacteria,1G183@1117|Cyanobacteria,1H8RE@1150|Oscillatoriales	1117|Cyanobacteria	C	PFAM Pentapeptide repeats (8 copies)	-	-	-	-	-	-	-	-	-	-	-	-	Pentapeptide,RDD
REGS3_k127_5555054_3	298655.KI912266_gene3050	5.404e-12	75.0	COG1357@1|root,COG1357@2|Bacteria,2IB55@201174|Actinobacteria	201174|Actinobacteria	S	PFAM pentapeptide repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	Pentapeptide
REGS3_k127_5555054_2	1077972.ARGLB_094_00180	1.491e-25	115.0	2EB70@1|root,3357M@2|Bacteria,2I9PW@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_5555054_0	1077972.ARGLB_094_00170	2.192e-194	609.0	COG2132@1|root,COG2132@2|Bacteria,2IN7A@201174|Actinobacteria	201174|Actinobacteria	Q	Multicopper oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase_2,Cu-oxidase_3
REGS3_k127_5570092_1	1313172.YM304_13870	5.413e-46	179.0	COG2755@1|root,COG2755@2|Bacteria	2|Bacteria	E	lipolytic protein G-D-S-L family	-	-	3.1.1.5	ko:K10804	ko01040,map01040	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	-	ChitinaseA_N,Lipase_GDSL_2
REGS3_k127_5570092_2	1122179.KB890414_gene1730	4.377e-13	75.0	COG1970@1|root,COG1970@2|Bacteria,4NQ49@976|Bacteroidetes,1IS4E@117747|Sphingobacteriia	976|Bacteroidetes	M	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell	mscL	-	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
REGS3_k127_5570092_0	1121918.ARWE01000001_gene2358	4.96e-49	188.0	COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,42MQZ@68525|delta/epsilon subdivisions,2X5D1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Molydopterin dinucleotide binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Molybdopterin,Molydop_binding
REGS3_k127_5570693_10	1313172.YM304_38470	1.368e-71	257.0	COG0491@1|root,COG0491@2|Bacteria	2|Bacteria	GM	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	-	-	1.3.1.34,3.1.2.6	ko:K00219,ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	Aminotran_5,Lactamase_B,Rhodanese
REGS3_k127_5570693_16	518766.Rmar_1282	7.41e-29	121.0	COG3030@1|root,COG3030@2|Bacteria,4PERU@976|Bacteroidetes,1FJHJ@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	FxsA cytoplasmic membrane protein	-	-	-	ko:K07113	-	-	-	-	ko00000	-	-	-	FxsA
REGS3_k127_5570693_2	288705.RSal33209_0599	1.969e-170	546.0	COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria,1W8P9@1268|Micrococcaceae	201174|Actinobacteria	C	Belongs to the aldehyde dehydrogenase family	aldC	-	1.2.1.3,1.2.1.39,1.2.1.78,1.2.1.8	ko:K00128,ko:K00130,ko:K00146,ko:K18275	ko00010,ko00053,ko00071,ko00260,ko00280,ko00310,ko00330,ko00340,ko00360,ko00380,ko00410,ko00561,ko00620,ko00624,ko00625,ko00643,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00260,map00280,map00310,map00330,map00340,map00360,map00380,map00410,map00561,map00620,map00624,map00625,map00643,map00903,map00981,map01100,map01110,map01120,map01130	M00135,M00555	R00264,R00631,R00710,R00904,R01752,R01986,R02536,R02549,R02565,R02566,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R05643,R06366,R08146	RC00047,RC00071,RC00075,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
REGS3_k127_5570693_6	1313172.YM304_38580	2.984e-84	282.0	COG1949@1|root,COG1949@2|Bacteria,2GJR7@201174|Actinobacteria,4CN0M@84992|Acidimicrobiia	84992|Acidimicrobiia	L	3'-to-5' exoribonuclease specific for small oligoribonucleotides	orn	-	-	ko:K13288	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	RNase_T
REGS3_k127_5570693_3	1313172.YM304_41440	1.915e-108	362.0	COG0491@1|root,COG0491@2|Bacteria,2GMDD@201174|Actinobacteria,4CNYR@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
REGS3_k127_5570693_13	1313172.YM304_21930	1.991e-43	169.0	COG3884@1|root,COG3884@2|Bacteria,2H0CD@201174|Actinobacteria,4CNBC@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Acyl-ACP thioesterase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-ACP_TE
REGS3_k127_5570693_15	1313172.YM304_38500	4.528e-32	132.0	2DMIS@1|root,32RVG@2|Bacteria,2IQ99@201174|Actinobacteria	201174|Actinobacteria	K	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA	whiB7	GO:0001101,GO:0008150,GO:0010033,GO:0033993,GO:0042221,GO:0046677,GO:0050896,GO:0070542,GO:1901700	-	ko:K18958	-	-	-	-	ko00000,ko03000	-	-	-	AT_hook,Whib
REGS3_k127_5570693_14	1313172.YM304_38490	2.288e-37	147.0	COG0526@1|root,COG0526@2|Bacteria,2HGGP@201174|Actinobacteria,4CNDV@84992|Acidimicrobiia	84992|Acidimicrobiia	CO	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	Redoxin
REGS3_k127_5570693_12	1313172.YM304_38480	2.644e-64	232.0	COG0785@1|root,COG0785@2|Bacteria,2I8T6@201174|Actinobacteria	201174|Actinobacteria	O	Cytochrome c biogenesis protein transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	DsbD
REGS3_k127_5570693_9	1313172.YM304_38590	5.827e-81	278.0	COG4195@1|root,COG4195@2|Bacteria,2GU51@201174|Actinobacteria	201174|Actinobacteria	C	Replication protein	-	-	-	-	-	-	-	-	-	-	-	-	AIG2_2,GGACT,Gamma_PGA_hydro
REGS3_k127_5570693_8	1313172.YM304_38620	9.951e-82	277.0	COG0259@1|root,COG0259@2|Bacteria,2GJCR@201174|Actinobacteria	201174|Actinobacteria	H	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)	pdxH	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0010181,GO:0016491,GO:0016614,GO:0016899,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0032553,GO:0034641,GO:0036094,GO:0042364,GO:0042802,GO:0042803,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0043167,GO:0043168,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046184,GO:0046483,GO:0046983,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	1.4.3.5	ko:K00275	ko00750,ko01100,ko01120,map00750,map01100,map01120	M00124	R00277,R00278,R01710,R01711	RC00048,RC00116	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2607	PNP_phzG_C,Putative_PNPOx
REGS3_k127_5570693_1	1313172.YM304_38630	3.541e-179	570.0	COG0172@1|root,COG0172@2|Bacteria,2GIWP@201174|Actinobacteria,4CMQR@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Seryl-tRNA synthetase N-terminal domain	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
REGS3_k127_5570693_7	1229780.BN381_450049	1.272e-83	286.0	COG1131@1|root,COG1131@2|Bacteria,2GJBF@201174|Actinobacteria,3UX8B@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	drrA_2	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
REGS3_k127_5570693_11	656024.FsymDg_1710	3.197e-67	238.0	COG0842@1|root,COG0842@2|Bacteria,2GN6S@201174|Actinobacteria,4ESTT@85013|Frankiales	201174|Actinobacteria	V	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane,ABC2_membrane_3
REGS3_k127_5570693_4	1313172.YM304_38640	1.839e-101	339.0	COG3336@1|root,COG3336@2|Bacteria,2HG9Q@201174|Actinobacteria,4CN83@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG)	-	-	-	ko:K02862	-	-	-	-	ko00000	-	-	-	Caa3_CtaG
REGS3_k127_5570693_17	1313172.YM304_38650	1.347e-23	104.0	2A8HP@1|root,30XJU@2|Bacteria,2HB16@201174|Actinobacteria	201174|Actinobacteria	S	Prokaryotic Cytochrome C oxidase subunit IV	-	-	1.9.3.1	ko:K02277	ko00190,ko01100,map00190,map01100	M00155	-	-	ko00000,ko00001,ko00002,ko01000	3.D.4.4	-	-	COX4_pro
REGS3_k127_5570693_5	1313172.YM304_38660	7.421e-87	293.0	COG1845@1|root,COG1845@2|Bacteria,2GKK8@201174|Actinobacteria,4CNAV@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Cytochrome c oxidase subunit III	-	-	1.9.3.1	ko:K02276,ko:K02299	ko00190,ko01100,map00190,map01100	M00155,M00417	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.5,3.D.4.6	-	-	COX3
REGS3_k127_5570693_0	1313172.YM304_38670	3.329e-213	666.0	COG0843@1|root,COG0843@2|Bacteria,2GJHX@201174|Actinobacteria,4CMUD@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
REGS3_k127_5583588_2	300852.55772819	2.635e-12	73.0	COG0664@1|root,COG0664@2|Bacteria,1WJXH@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	K	COGs COG0664 cAMP-binding protein - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinase	-	GO:0000166,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005515,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0017076,GO:0019219,GO:0019222,GO:0030551,GO:0030552,GO:0030554,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032553,GO:0032555,GO:0032559,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0046983,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
REGS3_k127_5583588_1	452863.Achl_3813	4.178e-24	109.0	COG0589@1|root,COG0589@2|Bacteria,2GSJK@201174|Actinobacteria,1WBQU@1268|Micrococcaceae	201174|Actinobacteria	T	Universal stress protein	uspA2	-	-	-	-	-	-	-	-	-	-	-	Usp
REGS3_k127_5583588_0	1380390.JIAT01000013_gene145	1.399e-199	668.0	COG0457@1|root,COG2114@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,2GJRI@201174|Actinobacteria	201174|Actinobacteria	T	Adenylyl cyclase class-3 4 guanylyl cyclase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Guanylate_cyc,TPR_12
REGS3_k127_5583588_4	1123386.AUIW01000001_gene258	0.0001148	55.0	COG4932@1|root,COG5624@1|root,COG4932@2|Bacteria,COG5624@2|Bacteria,1WJK4@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	K	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_5592681_1	637390.AFOH01000143_gene1300	2.304e-66	239.0	COG3239@1|root,COG3239@2|Bacteria,1MY4I@1224|Proteobacteria,1S6MX@1236|Gammaproteobacteria,2NCFQ@225057|Acidithiobacillales	225057|Acidithiobacillales	I	Fatty acid desaturase	-	-	1.14.19.23,1.14.19.45	ko:K10255	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	-	FA_desaturase
REGS3_k127_5592681_2	1123258.AQXZ01000010_gene3744	2.596e-51	203.0	COG4907@1|root,COG4907@2|Bacteria,2GNW7@201174|Actinobacteria,4G3G3@85025|Nocardiaceae	201174|Actinobacteria	S	Predicted membrane protein (DUF2207)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2207
REGS3_k127_5592681_0	479432.Sros_0368	2.063e-220	694.0	COG0513@1|root,COG0513@2|Bacteria,2GIUR@201174|Actinobacteria,4EI9T@85012|Streptosporangiales	201174|Actinobacteria	L	DbpA RNA binding domain	deaD	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030312,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360	3.6.4.13	ko:K05592,ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,DbpA,Helicase_C
REGS3_k127_5603341_9	1122611.KB903985_gene3626	2.233e-89	310.0	COG2828@1|root,COG2828@2|Bacteria,2GJF3@201174|Actinobacteria,4EMKF@85012|Streptosporangiales	201174|Actinobacteria	S	PrpF protein	-	-	5.3.2.8	ko:K16514	ko00362,ko01120,map00362,map01120	-	R07839	RC02426	ko00000,ko00001,ko01000	-	-	-	PrpF
REGS3_k127_5603341_3	1121374.KB891585_gene2190	9.88e-136	440.0	COG0673@1|root,COG0673@2|Bacteria,1MXUP@1224|Proteobacteria,1RP9K@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	dehydrogenases and related proteins	ligC	-	1.1.1.312	ko:K10219	ko00350,ko00362,ko00627,ko01120,ko01220,map00350,map00362,map00627,map01120,map01220	M00533	R04278,R04279,R04418,R04419	RC00251,RC00254	ko00000,ko00001,ko00002,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
REGS3_k127_5603341_1	1116375.VEJY3_18091	6.606e-158	503.0	COG2159@1|root,COG2159@2|Bacteria,1MVHB@1224|Proteobacteria,1RMYJ@1236|Gammaproteobacteria,1XVYI@135623|Vibrionales	135623|Vibrionales	S	Amidohydrolase	-	-	4.2.1.83	ko:K10220	ko00362,ko01120,map00362,map01120	-	R04478	RC00498	ko00000,ko00001,ko01000	-	-	-	Amidohydro_2
REGS3_k127_5603341_12	1245475.ANAE01000093_gene4376	2.208e-87	300.0	COG1414@1|root,COG1414@2|Bacteria,2GNHA@201174|Actinobacteria,4EGT8@85012|Streptosporangiales	201174|Actinobacteria	K	helix_turn_helix isocitrate lyase regulation	pcaR	-	-	ko:K02624	-	-	-	-	ko00000,ko03000	-	-	-	HTH_IclR,IclR
REGS3_k127_5603341_13	1301098.PKB_3292	4.801e-72	259.0	COG3485@1|root,COG3485@2|Bacteria,1MX7W@1224|Proteobacteria,1RP3H@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	catechol 1,2-dioxygenase	-	-	1.13.11.1	ko:K03381,ko:K15253	ko00361,ko00362,ko00364,ko00623,ko01100,ko01120,ko01220,map00361,map00362,map00364,map00623,map01100,map01120,map01220	M00568	R00817,R04258,R05299,R05407,R05409,R06833,R06839,R08114,R08115,R09134	RC00388,RC00535,RC01366	ko00000,ko00001,ko00002,ko01000	-	-	-	Dioxygenase_C,Dioxygenase_N
REGS3_k127_5603341_0	269800.Tfu_0875	8.527e-171	544.0	COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria,4EHEH@85012|Streptosporangiales	201174|Actinobacteria	I	Thiolase, C-terminal domain	pcaF	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
REGS3_k127_5603341_7	1108045.GORHZ_125_00810	5.774e-95	326.0	COG1454@1|root,COG1454@2|Bacteria,2I2FD@201174|Actinobacteria,4GDS1@85026|Gordoniaceae	201174|Actinobacteria	C	Iron-containing alcohol dehydrogenase	macA	-	1.3.1.32	ko:K00217	ko00361,ko00362,ko00364,ko00623,ko01100,ko01120,ko01220,map00361,map00362,map00364,map00623,map01100,map01120,map01220	-	R02988,R02989,R05355,R06848,R07781,R09137,R09138,R09223,R09224	RC00107,RC01335,RC01689,RC02442	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
REGS3_k127_5603341_6	1246995.AFR_19285	2.848e-95	322.0	COG2057@1|root,COG2057@2|Bacteria,2GMA1@201174|Actinobacteria,4DB71@85008|Micromonosporales	201174|Actinobacteria	I	Coenzyme A transferase	catJ	-	2.8.3.12	ko:K01040	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
REGS3_k127_5603341_5	247156.NFA_35190	2.034e-130	422.0	COG1788@1|root,COG1788@2|Bacteria,2I9F6@201174|Actinobacteria,4FZB8@85025|Nocardiaceae	201174|Actinobacteria	I	Coenzyme A transferase	catI	-	2.8.3.12	ko:K01039	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
REGS3_k127_5603341_4	1549858.MC45_16645	2.267e-132	438.0	28IZD@1|root,2Z8WU@2|Bacteria,1NEGQ@1224|Proteobacteria,2UZGH@28211|Alphaproteobacteria,2K8TY@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_5603341_15	1549858.MC45_16640	3.568e-54	196.0	28PSM@1|root,2ZCE4@2|Bacteria,1RBR6@1224|Proteobacteria,2V0GH@28211|Alphaproteobacteria,2K9CV@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_5603341_16	1034347.CAHJ01000049_gene399	4.608e-43	170.0	COG0400@1|root,COG0400@2|Bacteria	2|Bacteria	S	palmitoyl-(protein) hydrolase activity	-	-	-	ko:K06999,ko:K15975	-	-	-	-	ko00000	-	-	-	Abhydrolase_2,Glyoxalase
REGS3_k127_5603341_2	1123020.AUIE01000005_gene4255	4.74e-142	458.0	COG0346@1|root,COG0346@2|Bacteria,1P6TT@1224|Proteobacteria,1SAY1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	ko:K15975	-	-	-	-	ko00000	-	-	-	Glyoxalase
REGS3_k127_5603341_17	408672.NBCG_03465	7.557e-40	158.0	COG1802@1|root,COG1802@2|Bacteria,2HSE5@201174|Actinobacteria,4DUP0@85009|Propionibacteriales	201174|Actinobacteria	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
REGS3_k127_5603341_14	525368.HMPREF0591_2114	2.714e-64	228.0	COG0726@1|root,COG0726@2|Bacteria,2IFJ1@201174|Actinobacteria,239TS@1762|Mycobacteriaceae	201174|Actinobacteria	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
REGS3_k127_5603341_11	1463917.JODC01000017_gene2407	3.507e-88	300.0	COG0410@1|root,COG0410@2|Bacteria,2IB16@201174|Actinobacteria	201174|Actinobacteria	E	ABC transporter	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
REGS3_k127_5603341_8	543632.JOJL01000017_gene9960	3.121e-91	305.0	COG0411@1|root,COG0411@2|Bacteria,2I8N9@201174|Actinobacteria	201174|Actinobacteria	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,BCA_ABC_TP_C
REGS3_k127_5603341_10	1463917.JODC01000017_gene2409	1.37e-88	304.0	COG4177@1|root,COG4177@2|Bacteria,2IEMH@201174|Actinobacteria	201174|Actinobacteria	E	Branched-chain amino acid transport system / permease component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_2
REGS3_k127_5605421_5	448385.sce4570	3.346e-108	353.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,42MW3@68525|delta/epsilon subdivisions,2WJRZ@28221|Deltaproteobacteria,2YW7G@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	ppsA	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2101	PEP-utilizers,PEP-utilizers_C,PPDK_N
REGS3_k127_5605421_3	448385.sce4570	1.451e-140	462.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,42MW3@68525|delta/epsilon subdivisions,2WJRZ@28221|Deltaproteobacteria,2YW7G@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	ppsA	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2101	PEP-utilizers,PEP-utilizers_C,PPDK_N
REGS3_k127_5605421_1	1133850.SHJG_8767	1.879e-233	736.0	COG0365@1|root,COG0365@2|Bacteria,2GNE8@201174|Actinobacteria	201174|Actinobacteria	I	synthetase	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
REGS3_k127_5605421_4	1089544.KB912942_gene2769	6.343e-122	402.0	COG1071@1|root,COG1071@2|Bacteria,2IBRC@201174|Actinobacteria,4E12D@85010|Pseudonocardiales	201174|Actinobacteria	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	pdhA	-	1.2.4.1	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
REGS3_k127_5605421_2	1208323.B30_02780	1.313e-152	490.0	COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,2TRFK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Pyruvate 2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit	-	-	1.2.4.1	ko:K00162,ko:K21417	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
REGS3_k127_5605421_6	405948.SACE_2405	4.194e-105	359.0	COG0508@1|root,COG0508@2|Bacteria,2GN5J@201174|Actinobacteria,4E8QP@85010|Pseudonocardiales	201174|Actinobacteria	C	2-oxoacid dehydrogenases acyltransferase (catalytic domain)	-	-	2.3.1.12,2.3.1.61	ko:K00627,ko:K00658	ko00010,ko00020,ko00310,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00310,map00620,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032,M00307	R00209,R02569,R02570,R02571,R08549	RC00004,RC02727,RC02742,RC02833,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
REGS3_k127_5605421_9	1123228.AUIH01000001_gene1307	8.641e-09	62.0	COG0236@1|root,COG0236@2|Bacteria	2|Bacteria	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	PP-binding
REGS3_k127_5605421_0	1313172.YM304_15210	2.466e-254	793.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4CMUF@84992|Acidimicrobiia	84992|Acidimicrobiia	IQ	AMP-binding enzyme C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
REGS3_k127_5605421_8	1380347.JNII01000008_gene4279	1.146e-18	97.0	COG0791@1|root,COG0791@2|Bacteria,2GIWB@201174|Actinobacteria,4ESXT@85013|Frankiales	201174|Actinobacteria	M	PFAM NLP P60 protein	-	GO:0005575,GO:0005576	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	NLPC_P60
REGS3_k127_5605421_7	1306174.JODP01000005_gene1403	5.501e-79	272.0	COG2141@1|root,COG2141@2|Bacteria,2GJ6T@201174|Actinobacteria	201174|Actinobacteria	C	F420-dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
REGS3_k127_56817_1	928724.SacglDRAFT_03311	3.448e-159	515.0	COG1488@1|root,COG1488@2|Bacteria,2GJAT@201174|Actinobacteria,4DXVH@85010|Pseudonocardiales	201174|Actinobacteria	H	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP	pncB	GO:0003674,GO:0003824,GO:0004516,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0016874,GO:0016879,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0019674,GO:0030312,GO:0034355,GO:0034641,GO:0034654,GO:0043094,GO:0043173,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044464,GO:0046483,GO:0046496,GO:0047280,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	-	NAPRTase,QRPTase_C
REGS3_k127_56817_4	246200.SPO3350	9.516e-28	121.0	COG3795@1|root,COG3795@2|Bacteria,1RJJG@1224|Proteobacteria,2UCR2@28211|Alphaproteobacteria,4NCMU@97050|Ruegeria	28211|Alphaproteobacteria	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
REGS3_k127_56817_0	1313172.YM304_15840	8.899e-280	869.0	COG0442@1|root,COG0442@2|Bacteria,2GJ9G@201174|Actinobacteria,4CMX4@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Aminoacyl-tRNA editing domain	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
REGS3_k127_56817_3	1313172.YM304_15870	1.294e-52	192.0	COG0779@1|root,COG0779@2|Bacteria,2HH26@201174|Actinobacteria,4CP28@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Required for maturation of 30S ribosomal subunits	rimP	-	-	ko:K09748	-	-	-	-	ko00000,ko03009	-	-	-	DUF150,DUF150_C
REGS3_k127_56817_2	1313172.YM304_15880	3.501e-80	270.0	COG0195@1|root,COG0195@2|Bacteria,2GJDJ@201174|Actinobacteria,4CMPR@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_5,NusA_N,S1
REGS3_k127_5718614_8	1120963.KB894491_gene1107	2.569e-05	47.0	2DE24@1|root,2ZK69@2|Bacteria,1P9N5@1224|Proteobacteria,1SU0Y@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_5718614_0	35754.JNYJ01000037_gene4628	0.0	1099.0	COG1452@1|root,COG1452@2|Bacteria,2GNM6@201174|Actinobacteria,4DMCF@85008|Micromonosporales	201174|Actinobacteria	M	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_63
REGS3_k127_5718614_3	1123024.AUII01000044_gene601	7.31e-150	481.0	COG1063@1|root,COG1063@2|Bacteria,2GKFG@201174|Actinobacteria,4E0X4@85010|Pseudonocardiales	201174|Actinobacteria	E	Glucose dehydrogenase C-terminus	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,Glu_dehyd_C
REGS3_k127_5718614_4	391165.GbCGDNIH1_0537	2.28e-78	270.0	COG1940@1|root,COG1940@2|Bacteria,1NSQA@1224|Proteobacteria,2TSPZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	GK	Transcriptional regulator sugar kinase	-	-	2.7.1.63	ko:K00886	ko00010,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R02187,R02189	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
REGS3_k127_5718614_7	1172180.KB911775_gene6126	5.378e-57	205.0	COG0346@1|root,COG0346@2|Bacteria,2GRGB@201174|Actinobacteria	201174|Actinobacteria	E	Glyoxalase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase_3
REGS3_k127_5718614_6	1206720.BAFQ01000139_gene3510	1.195e-67	248.0	COG0790@1|root,COG0790@2|Bacteria,2GKCE@201174|Actinobacteria,4G2RR@85025|Nocardiaceae	201174|Actinobacteria	V	Sel1-like repeats.	-	-	-	ko:K07126	-	-	-	-	ko00000	-	-	-	Sel1,TPR_10,TPR_16,TPR_4
REGS3_k127_5718614_5	1169161.KB897729_gene1360	1.127e-77	267.0	COG0500@1|root,COG0500@2|Bacteria,2I8Y2@201174|Actinobacteria	201174|Actinobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
REGS3_k127_5718614_1	1122135.KB893166_gene2825	9.331e-306	956.0	COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,1MUXJ@1224|Proteobacteria,2TRGS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Belongs to the GcvT family	dmgdh4	-	1.5.8.4	ko:K00315	ko00260,ko01100,map00260,map01100	-	R01565	RC00181	ko00000,ko00001,ko01000	-	-	-	DAO,FAO_M,GCV_T,GCV_T_C
REGS3_k127_5718614_2	1126627.BAWE01000006_gene6551	9.782e-265	823.0	COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,1MUXJ@1224|Proteobacteria,2TRGS@28211|Alphaproteobacteria,3JXXJ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	FAD dependent oxidoreductase	sardh	-	1.5.3.19	ko:K19191	ko00760,ko01120,map00760,map01120	-	R10102	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO,FAO_M,GCV_T,GCV_T_C
REGS3_k127_5791298_7	526225.Gobs_3545	5.82e-11	64.0	COG0604@1|root,COG0604@2|Bacteria,2GIS3@201174|Actinobacteria,4EU25@85013|Frankiales	201174|Actinobacteria	C	PFAM Alcohol dehydrogenase zinc-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N_2
REGS3_k127_5791298_3	1435356.Y013_17170	7.941e-81	286.0	COG0477@1|root,COG2814@2|Bacteria,2I2EY@201174|Actinobacteria,4G9I9@85025|Nocardiaceae	201174|Actinobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
REGS3_k127_5791298_2	134676.ACPL_2558	1.384e-85	297.0	COG0372@1|root,COG0789@1|root,COG0372@2|Bacteria,COG0789@2|Bacteria,2GM3G@201174|Actinobacteria,4DCXN@85008|Micromonosporales	201174|Actinobacteria	CK	Citrate synthase, C-terminal domain	-	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt,HTH_17
REGS3_k127_5791298_0	526226.Gbro_3561	3.221e-152	496.0	COG0372@1|root,COG0372@2|Bacteria,2GKST@201174|Actinobacteria,4GCME@85026|Gordoniaceae	201174|Actinobacteria	C	Citrate synthase, C-terminal domain	citA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
REGS3_k127_5791298_1	1353528.DT23_14940	1.002e-131	432.0	COG3550@1|root,COG3550@2|Bacteria,1N458@1224|Proteobacteria,2TVQF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	PFAM HipA domain protein	-	-	2.7.11.1	ko:K07154	-	-	-	-	ko00000,ko01000,ko01001,ko02048	-	-	-	Couple_hipA,HipA_C
REGS3_k127_5791298_5	1184609.KILIM_020_00070	6.164e-23	101.0	COG1476@1|root,COG1476@2|Bacteria,2GQVU@201174|Actinobacteria	201174|Actinobacteria	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_31
REGS3_k127_5791298_6	2074.JNYD01000024_gene2834	2.603e-15	87.0	2BTY3@1|root,32P6C@2|Bacteria,2I8RQ@201174|Actinobacteria,4ECZJ@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
REGS3_k127_5791298_4	1035308.AQYY01000001_gene1395	3.938e-47	177.0	COG1595@1|root,COG1595@2|Bacteria,1V4B8@1239|Firmicutes	1239|Firmicutes	K	Belongs to the sigma-70 factor family. ECF subfamily	sigK_1	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
REGS3_k127_5800390_1	1385521.N803_08405	2.083e-11	74.0	2EM6P@1|root,33EVW@2|Bacteria,2GYP2@201174|Actinobacteria,4FJ04@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_5800390_0	1313172.YM304_26330	3.028e-150	484.0	COG0247@1|root,COG0247@2|Bacteria,2GIVX@201174|Actinobacteria,4CN2B@84992|Acidimicrobiia	84992|Acidimicrobiia	C	4Fe-4S dicluster domain	-	-	-	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	CCG,Fer4_7
REGS3_k127_5856139_1	1313172.YM304_32680	3.953e-100	332.0	COG0778@1|root,COG0778@2|Bacteria,2IKKD@201174|Actinobacteria	201174|Actinobacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
REGS3_k127_5856139_0	1380390.JIAT01000013_gene45	3.729e-146	503.0	COG3349@1|root,COG3349@2|Bacteria,2I7PZ@201174|Actinobacteria,4CRNZ@84995|Rubrobacteria	84995|Rubrobacteria	S	NAD(P)-binding Rossmann-like domain	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_8
REGS3_k127_5856139_3	1283299.AUKG01000001_gene2438	1.559e-56	226.0	COG0665@1|root,COG0665@2|Bacteria,2HQ72@201174|Actinobacteria,4CRQ9@84995|Rubrobacteria	84995|Rubrobacteria	E	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_5856139_2	47839.CCAU010000002_gene2530	5.898e-57	222.0	COG2114@1|root,COG2197@1|root,COG3903@1|root,COG2114@2|Bacteria,COG2197@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria,233DM@1762|Mycobacteriaceae	201174|Actinobacteria	K	involved in signal transduction (via phosphorylation) involved in transcriptional regulatory mechanism and in the regulation of secondary metabolites catalytic activity ATP a protein ADP a phosphoprotein	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	GerE,Guanylate_cyc,NB-ARC
REGS3_k127_5876248_3	1313172.YM304_02290	1.13e-106	362.0	COG0654@1|root,COG0654@2|Bacteria,2I901@201174|Actinobacteria	201174|Actinobacteria	CH	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	DAO,FAD_binding_2,NAD_binding_8,Trp_halogenase
REGS3_k127_5876248_13	1313172.YM304_37940	7.369e-22	100.0	2CKCH@1|root,331PP@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_5876248_8	1158050.KB895473_gene2736	1.445e-84	296.0	COG3485@1|root,COG3485@2|Bacteria,2GMAP@201174|Actinobacteria,1W7SS@1268|Micrococcaceae	201174|Actinobacteria	Q	Dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Dioxygenase_C
REGS3_k127_5876248_0	525909.Afer_1846	1.219e-273	850.0	COG0459@1|root,COG0459@2|Bacteria,2GKC9@201174|Actinobacteria,4CNG0@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	-	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
REGS3_k127_5876248_9	1313172.YM304_15590	6.29e-83	292.0	COG5340@1|root,COG5340@2|Bacteria	2|Bacteria	K	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	AbiEi_4,DUF559
REGS3_k127_5876248_6	1313172.YM304_36880	3.791e-98	347.0	COG1653@1|root,COG1653@2|Bacteria	2|Bacteria	G	carbohydrate transport	-	-	-	ko:K05813	ko02010,map02010	M00198	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.3	-	-	SBP_bac_8
REGS3_k127_5876248_10	1229780.BN381_20065	8.936e-69	246.0	COG0395@1|root,COG0395@2|Bacteria,2GMTH@201174|Actinobacteria,3UWR1@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	P	COG0395 ABC-type sugar transport system, permease component	-	-	-	ko:K02026,ko:K05815	ko02010,map02010	M00198,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.3	-	-	BPD_transp_1
REGS3_k127_5876248_7	1313172.YM304_36900	6.908e-94	325.0	COG1175@1|root,COG1175@2|Bacteria,2GKJI@201174|Actinobacteria	201174|Actinobacteria	G	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K05814	ko02010,map02010	M00198	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.3	-	-	BPD_transp_1
REGS3_k127_5876248_5	1120934.KB894434_gene4621	3.22e-101	340.0	COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria,4E9QM@85010|Pseudonocardiales	201174|Actinobacteria	E	TOBE domain	-	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE_2
REGS3_k127_5876248_14	1313172.YM304_03910	6.841e-10	62.0	COG1734@1|root,COG1734@2|Bacteria	2|Bacteria	T	zinc ion binding	-	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
REGS3_k127_5876248_1	1313172.YM304_03900	1.125e-168	550.0	COG0661@1|root,COG0661@2|Bacteria,2GJQ6@201174|Actinobacteria,4CMRN@84992|Acidimicrobiia	84992|Acidimicrobiia	S	ABC1 family	-	-	-	-	-	-	-	-	-	-	-	-	ABC1
REGS3_k127_5876248_2	1313172.YM304_03860	5.241e-126	409.0	COG2833@1|root,COG2833@2|Bacteria	2|Bacteria	I	Protein of unknown function (DUF455)	-	-	2.7.1.165	ko:K11529	ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200	M00346	R08572	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF455
REGS3_k127_5876248_11	1123320.KB889673_gene3636	2.898e-43	166.0	COG1028@1|root,COG1028@2|Bacteria,2GJ1F@201174|Actinobacteria	201174|Actinobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
REGS3_k127_5887224_4	1313172.YM304_12770	9.463e-99	331.0	COG0513@1|root,COG0513@2|Bacteria,2GIUR@201174|Actinobacteria,4CNI4@84992|Acidimicrobiia	201174|Actinobacteria	JKL	DEAD-like helicases superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DEAD,Helicase_C
REGS3_k127_5887224_1	1313172.YM304_12220	2.051e-158	508.0	COG0626@1|root,COG0626@2|Bacteria,2GJ5S@201174|Actinobacteria,4CNIM@84992|Acidimicrobiia	201174|Actinobacteria	E	Cys/Met metabolism PLP-dependent enzyme	megL	-	2.5.1.48,2.5.1.49,4.4.1.11	ko:K01739,ko:K01740,ko:K01761	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00654,R00999,R01287,R01288,R02508,R03217,R03260,R04770,R04859,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00196,RC00348,RC00420,RC01209,RC01210,RC02821,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
REGS3_k127_5887224_6	1423321.AS29_02070	6.075e-27	123.0	COG1647@1|root,COG1647@2|Bacteria,1TQ7X@1239|Firmicutes,4IR5Q@91061|Bacilli,1ZRRV@1386|Bacillus	91061|Bacilli	S	Alpha/beta hydrolase family	-	-	3.1.1.1	ko:K03928	-	-	-	-	ko00000,ko01000	-	-	-	Hydrolase_4
REGS3_k127_5887224_0	1504319.GM45_3420	5.232e-182	581.0	COG5310@1|root,COG5310@2|Bacteria,2IRSZ@201174|Actinobacteria	201174|Actinobacteria	Q	Saccharopine dehydrogenase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP
REGS3_k127_5887224_2	247156.NFA_26920	4.133e-119	392.0	COG2141@1|root,COG2141@2|Bacteria,2GNE9@201174|Actinobacteria,4FVS0@85025|Nocardiaceae	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
REGS3_k127_5887224_9	1150864.MILUP08_46832	0.0001225	55.0	2EBG5@1|root,335GQ@2|Bacteria,2GRUT@201174|Actinobacteria,4DFPV@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_5887224_7	1121946.AUAX01000022_gene3829	1.979e-20	106.0	COG3409@1|root,COG3409@2|Bacteria,2I9HW@201174|Actinobacteria,4DAG2@85008|Micromonosporales	201174|Actinobacteria	M	Putative peptidoglycan binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_3,PG_binding_1
REGS3_k127_5887224_5	1313172.YM304_32190	1.021e-91	309.0	COG1136@1|root,COG1136@2|Bacteria,2GK3I@201174|Actinobacteria,4CP56@84992|Acidimicrobiia	84992|Acidimicrobiia	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
REGS3_k127_5887224_3	1313172.YM304_32200	1.05e-118	395.0	COG0577@1|root,COG0577@2|Bacteria,2GIRW@201174|Actinobacteria,4CNZP@84992|Acidimicrobiia	84992|Acidimicrobiia	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
REGS3_k127_5887224_8	1380354.JIAN01000005_gene1648	2.108e-17	92.0	COG3409@1|root,COG3409@2|Bacteria,2I9HW@201174|Actinobacteria,4F2QJ@85016|Cellulomonadaceae	201174|Actinobacteria	M	Putative peptidoglycan binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_3,PG_binding_1
REGS3_k127_5894296_10	1313172.YM304_09250	1.019e-17	86.0	COG3387@1|root,COG3387@2|Bacteria,2GKU7@201174|Actinobacteria,4CN1W@84992|Acidimicrobiia	84992|Acidimicrobiia	G	PFAM Glycoside hydrolase 15-related	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_5894296_4	1313172.YM304_09260	1.97e-115	377.0	COG0500@1|root,COG2226@2|Bacteria,2H38T@201174|Actinobacteria	201174|Actinobacteria	Q	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
REGS3_k127_5894296_0	1313172.YM304_09270	1.752e-221	693.0	COG0297@1|root,COG0438@1|root,COG0297@2|Bacteria,COG0438@2|Bacteria,2GMXE@201174|Actinobacteria,4CMVF@84992|Acidimicrobiia	84992|Acidimicrobiia	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4
REGS3_k127_5894296_6	1429851.X548_08710	1.567e-74	262.0	COG2017@1|root,COG2017@2|Bacteria,1N5HJ@1224|Proteobacteria,1S9UC@1236|Gammaproteobacteria,1X2ZF@135614|Xanthomonadales	135614|Xanthomonadales	G	Aldose 1-epimerase	-	-	5.1.3.3	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	M00632	R01602,R10619	RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldose_epim
REGS3_k127_5894296_8	1313172.YM304_09310	1.271e-44	168.0	COG1490@1|root,COG1490@2|Bacteria,2IKVR@201174|Actinobacteria	201174|Actinobacteria	J	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality	dtd	GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360	-	ko:K07560	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Tyr_Deacylase
REGS3_k127_5894296_1	1313172.YM304_09320	1.121e-176	567.0	COG0815@1|root,COG0815@2|Bacteria,2GJ9F@201174|Actinobacteria	201174|Actinobacteria	M	Transfers the fatty acyl group on membrane lipoproteins	lnt	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
REGS3_k127_5894296_7	1313172.YM304_09330	1.037e-50	187.0	COG3764@1|root,COG3764@2|Bacteria	2|Bacteria	M	Sortase family	-	-	3.4.22.70	ko:K07284	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Sortase
REGS3_k127_5894296_3	1313172.YM304_09340	2.025e-122	410.0	COG1232@1|root,COG1232@2|Bacteria,2GMMA@201174|Actinobacteria,4CN93@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Flavin containing amine oxidoreductase	hemY	-	1.3.3.15,1.3.3.4	ko:K00231	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03222,R04178	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
REGS3_k127_5894296_5	1229780.BN381_100024	2.76e-85	295.0	COG0276@1|root,COG0276@2|Bacteria,2GJTQ@201174|Actinobacteria,3UWVK@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	H	Catalyzes the ferrous insertion into protoporphyrin IX	hemH	-	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	Ferrochelatase
REGS3_k127_5894296_2	1229780.BN381_100025	8.1e-123	409.0	COG0407@1|root,COG0407@2|Bacteria,2GMY6@201174|Actinobacteria,3UWFA@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	hemE	GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
REGS3_k127_5894296_9	1313172.YM304_11290	5.08e-39	152.0	COG1403@1|root,COG1403@2|Bacteria,2ICGQ@201174|Actinobacteria	201174|Actinobacteria	V	Domain of unknown function (DUF222)	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
REGS3_k127_6014595_1	351607.Acel_0442	3.292e-43	177.0	COG5305@1|root,COG5305@2|Bacteria,2IDAQ@201174|Actinobacteria,4EW9F@85013|Frankiales	201174|Actinobacteria	S	Predicted membrane protein (DUF2142)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2142
REGS3_k127_6014595_0	1313172.YM304_24390	5e-323	996.0	COG1048@1|root,COG1048@2|Bacteria,2GJD5@201174|Actinobacteria,4CMQB@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Aconitase family (aconitate hydratase)	-	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
REGS3_k127_6049336_15	1463845.JOIG01000005_gene3274	4.062e-17	83.0	COG1995@1|root,COG1995@2|Bacteria,2GRPG@201174|Actinobacteria	201174|Actinobacteria	H	Belongs to the PdxA family	pdxA	-	1.1.1.262,1.1.1.408,1.1.1.409	ko:K00097,ko:K22024	ko00750,ko01100,map00750,map01100	M00124	R05681,R05837,R07406	RC00089,RC00675,RC01475	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1357_C,DUF1537,PdxA
REGS3_k127_6049336_12	1205910.B005_4066	1.838e-32	140.0	COG3395@1|root,COG3395@2|Bacteria,2GNIH@201174|Actinobacteria,4EPMA@85012|Streptosporangiales	201174|Actinobacteria	S	Putative sugar-binding N-terminal domain	-	-	2.7.1.219,2.7.1.220	ko:K22129	-	-	-	-	ko00000,ko01000	-	-	-	DUF1357_C,DUF1537
REGS3_k127_6049336_3	1370121.AUWS01000022_gene6368	1.856e-139	451.0	COG1052@1|root,COG1052@2|Bacteria,2I2RK@201174|Actinobacteria,238HE@1762|Mycobacteriaceae	201174|Actinobacteria	CH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	-	-	1.1.1.26	ko:K00015	ko00630,ko01100,ko01110,ko01120,map00630,map01100,map01110,map01120	-	R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
REGS3_k127_6049336_1	1089455.MOPEL_027_00150	4.858e-191	607.0	COG0436@1|root,COG0436@2|Bacteria,2GJ7R@201174|Actinobacteria,4F7NZ@85018|Dermatophilaceae	201174|Actinobacteria	E	DegT/DnrJ/EryC1/StrS aminotransferase family	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
REGS3_k127_6049336_9	1144342.PMI40_01056	5.008e-84	296.0	COG0697@1|root,COG0697@2|Bacteria,1MVHN@1224|Proteobacteria,2VI21@28216|Betaproteobacteria,4736N@75682|Oxalobacteraceae	28216|Betaproteobacteria	EG	of the drug metabolite transporter (DMT)	-	-	-	-	-	-	-	-	-	-	-	-	EamA
REGS3_k127_6049336_4	1121106.JQKB01000028_gene4203	1.105e-135	445.0	COG2081@1|root,COG2081@2|Bacteria,1MUGC@1224|Proteobacteria,2TR1K@28211|Alphaproteobacteria,2JPY2@204441|Rhodospirillales	204441|Rhodospirillales	S	HI0933-like protein	-	-	-	ko:K07007	-	-	-	-	ko00000	-	-	-	HI0933_like
REGS3_k127_6049336_16	929712.KI912613_gene1694	8.276e-17	91.0	COG3794@1|root,COG3794@2|Bacteria	2|Bacteria	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cupredoxin_1,Cytochrom_C
REGS3_k127_6049336_2	671143.DAMO_0766	4.41e-149	494.0	COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,2NNUW@2323|unclassified Bacteria	2|Bacteria	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	pcmB	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6,1.97.1.9	ko:K03388,ko:K12527	ko00450,ko00680,ko01100,ko01120,ko01200,map00450,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R07229,R11928,R11931,R11943,R11944	RC00011,RC02420	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_20,FlpD,Pyr_redox_2,Pyr_redox_3
REGS3_k127_6049336_6	234267.Acid_3505	2.152e-102	350.0	COG1290@1|root,COG1290@2|Bacteria	2|Bacteria	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	petB	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_B_C,Cytochrome_B
REGS3_k127_6049336_14	1313172.YM304_04030	5.176e-24	107.0	COG0723@1|root,COG0723@2|Bacteria	2|Bacteria	C	oxidoreductase activity, acting on diphenols and related substances as donors	-	-	1.10.9.1	ko:K02636,ko:K03886	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00151,M00162	R03817,R08409	RC01002	ko00000,ko00001,ko00002,ko00194,ko01000	-	-	-	Rieske
REGS3_k127_6049336_17	1122604.JONR01000008_gene2189	8.095e-06	54.0	COG2010@1|root,COG2133@1|root,COG2010@2|Bacteria,COG2133@2|Bacteria,1MVK5@1224|Proteobacteria,1RPE8@1236|Gammaproteobacteria,1X59I@135614|Xanthomonadales	135614|Xanthomonadales	CG	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,GSDH
REGS3_k127_6049336_8	234267.Acid_0085	1.479e-89	319.0	COG1132@1|root,COG1132@2|Bacteria,3Y6PT@57723|Acidobacteria	57723|Acidobacteria	V	ABC transporter transmembrane region	-	-	-	ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106	-	-	ABC_membrane,ABC_tran
REGS3_k127_6049336_13	1380346.JNIH01000002_gene6317	2.126e-27	123.0	COG0515@1|root,COG0515@2|Bacteria,2GIV0@201174|Actinobacteria	201174|Actinobacteria	KLT	serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
REGS3_k127_6049336_0	585531.HMPREF0063_10177	3.299e-212	674.0	COG3670@1|root,COG3670@2|Bacteria,2GK7D@201174|Actinobacteria	201174|Actinobacteria	Q	dioxygenase	-	-	-	ko:K11159	-	-	-	-	ko00000	-	-	-	RPE65
REGS3_k127_6049336_5	228405.HNE_0057	2.655e-120	403.0	COG2159@1|root,COG2159@2|Bacteria,1P6G6@1224|Proteobacteria,2TU10@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	metal-dependent hydrolase of the TIM-barrel fold	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
REGS3_k127_6049336_7	338963.Pcar_2558	1.206e-94	336.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,42M0W@68525|delta/epsilon subdivisions,2WIK8@28221|Deltaproteobacteria,43TNR@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	GGDEF domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF_2,GGDEF,PAS,PAS_3,PAS_9,Response_reg
REGS3_k127_6049336_11	1042326.AZNV01000045_gene739	3.11e-61	219.0	COG1814@1|root,COG1814@2|Bacteria,1MUZE@1224|Proteobacteria,2TT6M@28211|Alphaproteobacteria,4B8G2@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	VIT family	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
REGS3_k127_6049336_10	1449976.KALB_3642	2.51e-82	289.0	COG5607@1|root,COG5607@2|Bacteria,2GJZH@201174|Actinobacteria,4EAUR@85010|Pseudonocardiales	201174|Actinobacteria	S	CYTH	-	-	-	-	-	-	-	-	-	-	-	-	CHAD,CYTH
REGS3_k127_6055_6	1313172.YM304_16500	1.039e-72	248.0	COG0621@1|root,COG0621@2|Bacteria,2GJEV@201174|Actinobacteria,4CMWG@84992|Acidimicrobiia	2|Bacteria	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	rimO	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016782,GO:0018193,GO:0018197,GO:0018198,GO:0018339,GO:0019538,GO:0035596,GO:0035599,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050497,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901564	2.8.4.4	ko:K14441	-	-	R10652	RC00003,RC03217	ko00000,ko01000,ko03009	-	-	-	Radical_SAM,TRAM,UPF0004
REGS3_k127_6055_3	1313172.YM304_16460	1.2e-144	465.0	COG3386@1|root,COG3386@2|Bacteria	2|Bacteria	G	gluconolactonase activity	-	-	3.1.1.17	ko:K01053	ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02933,R03751	RC00537,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	SGL
REGS3_k127_6055_1	1229780.BN381_80302	9.772e-207	669.0	COG1674@1|root,COG1674@2|Bacteria,2GK3T@201174|Actinobacteria,3UW6P@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	D	Ftsk_gamma	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
REGS3_k127_6055_0	1313172.YM304_16400	4.169e-266	828.0	COG0595@1|root,COG0595@2|Bacteria,2GIW7@201174|Actinobacteria,4CMS5@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Zn-dependent metallo-hydrolase RNA specificity domain	-	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,RMMBL
REGS3_k127_6055_4	1313172.YM304_16390	8.645e-115	379.0	COG0329@1|root,COG0329@2|Bacteria,2GJ34@201174|Actinobacteria,4CN0H@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
REGS3_k127_6055_8	1313172.YM304_16380	1.744e-69	245.0	2B34Q@1|root,31VSF@2|Bacteria,2I9DC@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_6055_9	643648.Slip_0667	3.501e-27	121.0	COG0491@1|root,COG0491@2|Bacteria,1UU56@1239|Firmicutes,24BKN@186801|Clostridia	186801|Clostridia	M	PFAM Metallo-beta-lactamase superfamily	-	-	3.1.1.81	ko:K13075	ko02024,map02024	-	R08970	RC00713	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
REGS3_k127_6055_13	1211815.CBYP010000046_gene823	5.323e-12	76.0	COG2852@1|root,COG2852@2|Bacteria,2GN40@201174|Actinobacteria	201174|Actinobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF559
REGS3_k127_6055_7	404589.Anae109_0474	5.799e-72	251.0	COG4106@1|root,COG4106@2|Bacteria,1Q2Y3@1224|Proteobacteria,43A9Z@68525|delta/epsilon subdivisions,2X37W@28221|Deltaproteobacteria,2YV2G@29|Myxococcales	28221|Deltaproteobacteria	S	Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate	tam	-	2.1.1.144	ko:K00598	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_23,Methyltransf_25
REGS3_k127_6055_2	1229780.BN381_80295	6.222e-157	508.0	COG0208@1|root,COG0208@2|Bacteria,2GJKZ@201174|Actinobacteria	201174|Actinobacteria	F	P-aminobenzoate N-oxygenase AurF	-	-	-	-	-	-	-	-	-	-	-	-	AurF
REGS3_k127_6055_11	1206732.BAGD01000053_gene1875	4.597e-17	91.0	COG1309@1|root,COG1309@2|Bacteria,2IPSV@201174|Actinobacteria,4FVHY@85025|Nocardiaceae	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
REGS3_k127_6055_5	1122223.KB890696_gene72	2.68e-113	369.0	COG1126@1|root,COG1126@2|Bacteria,1WI0Q@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	ABC-type polar amino acid transport system ATPase component	-	-	3.6.3.21	ko:K02028	-	M00236	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.3	-	-	ABC_tran
REGS3_k127_6055_10	266779.Meso_3148	1.719e-25	108.0	COG0765@1|root,COG0765@2|Bacteria,1N786@1224|Proteobacteria,2U10S@28211|Alphaproteobacteria,43ITH@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Polar amino acid ABC transporter	-	-	-	ko:K02029	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	BPD_transp_1
REGS3_k127_6075525_5	1449976.KALB_2064	1.533e-100	360.0	28NE7@1|root,2ZBGS@2|Bacteria,2GMIK@201174|Actinobacteria,4EF99@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_6075525_6	1123073.KB899241_gene3463	3.81e-88	323.0	COG0726@1|root,COG0726@2|Bacteria	2|Bacteria	G	polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Formyl_trans_C,Formyl_trans_N,GHL10,Polysacc_deac_1
REGS3_k127_6075525_2	1313172.YM304_19680	3.951e-129	418.0	COG0623@1|root,COG0623@2|Bacteria,2GJ65@201174|Actinobacteria,4CMWN@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Enoyl-(Acyl carrier protein) reductase	-	-	1.3.1.10,1.3.1.9	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
REGS3_k127_6075525_4	1313172.YM304_19690	2.022e-105	346.0	COG2085@1|root,COG2085@2|Bacteria,2GMZ5@201174|Actinobacteria,4CN3R@84992|Acidimicrobiia	84992|Acidimicrobiia	S	NADP oxidoreductase coenzyme F420-dependent	-	-	1.5.1.40	ko:K06988	-	-	-	-	ko00000,ko01000	-	-	-	F420_oxidored
REGS3_k127_6075525_1	1313172.YM304_19700	1.536e-192	605.0	COG0215@1|root,COG0215@2|Bacteria,2GJZR@201174|Actinobacteria,4CMRH@84992|Acidimicrobiia	84992|Acidimicrobiia	H	tRNA synthetases class I (C) catalytic domain	mshC	-	6.3.1.13	ko:K15526	-	-	-	-	ko00000,ko01000	-	-	-	tRNA-synt_1e
REGS3_k127_6075525_8	1229780.BN381_50170	2.616e-74	261.0	COG0204@1|root,COG0204@2|Bacteria,2GJ6V@201174|Actinobacteria,3UWK8@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	I	Phosphate acyltransferases	plsC2	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
REGS3_k127_6075525_0	1120950.KB892708_gene4256	7.788e-224	714.0	COG0441@1|root,COG0441@2|Bacteria,2GKTC@201174|Actinobacteria,4DN38@85009|Propionibacteriales	201174|Actinobacteria	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_SAD
REGS3_k127_6075525_10	1313172.YM304_19730	2.355e-61	217.0	COG0537@1|root,COG0537@2|Bacteria,2GJT5@201174|Actinobacteria,4CN4U@84992|Acidimicrobiia	84992|Acidimicrobiia	FG	HIT domain	-	-	2.7.7.53	ko:K19710	ko00230,map00230	-	R00126,R01618	RC00002,RC02753,RC02795	ko00000,ko00001,ko01000	-	-	-	HIT
REGS3_k127_6075525_9	1313172.YM304_19740	2.794e-62	218.0	2F9Q3@1|root,34209@2|Bacteria,2H616@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_6075525_7	1313172.YM304_19750	5.152e-84	289.0	COG0558@1|root,COG0558@2|Bacteria,2GYKW@201174|Actinobacteria,4CN1P@84992|Acidimicrobiia	84992|Acidimicrobiia	I	CDP-alcohol phosphatidyltransferase	-	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
REGS3_k127_6075525_3	1313172.YM304_19760	1.952e-112	370.0	COG1560@1|root,COG1560@2|Bacteria,2GM7B@201174|Actinobacteria,4CN56@84992|Acidimicrobiia	84992|Acidimicrobiia	M	Bacterial lipid A biosynthesis acyltransferase	-	-	2.3.1.265	ko:K22311	-	-	-	-	ko00000,ko01000	-	-	-	Lip_A_acyltrans
REGS3_k127_6075525_11	40571.JOEA01000005_gene4187	5.125e-50	180.0	COG1359@1|root,COG1359@2|Bacteria,2IQ6Y@201174|Actinobacteria,4E4NZ@85010|Pseudonocardiales	201174|Actinobacteria	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
REGS3_k127_6075525_12	1463909.KL585947_gene5105	3.912e-25	108.0	COG0500@1|root,COG2226@2|Bacteria,2GP9N@201174|Actinobacteria	201174|Actinobacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
REGS3_k127_6081255_2	1150599.MPHLEI_14699	3.149e-53	189.0	COG4638@1|root,COG4638@2|Bacteria,2GKJY@201174|Actinobacteria,2361S@1762|Mycobacteriaceae	201174|Actinobacteria	P	COG4638 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit	-	-	-	-	-	-	-	-	-	-	-	-	Rieske,Ring_hydroxyl_A
REGS3_k127_6081255_3	110319.CF8_0530	1.304e-07	63.0	2DPU0@1|root,333DA@2|Bacteria,2IARZ@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_6081255_1	1313172.YM304_01590	1.27e-136	442.0	COG0388@1|root,COG0388@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	-	-	3.5.1.77	ko:K01459	-	-	-	-	ko00000,ko01000	-	-	-	CN_hydrolase
REGS3_k127_6081255_0	1313172.YM304_04570	2.528e-233	772.0	COG1674@1|root,COG1716@1|root,COG1674@2|Bacteria,COG1716@2|Bacteria,2GJBR@201174|Actinobacteria	201174|Actinobacteria	D	DNA segregation ATPase FtsK SpoIIIE and related	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FHA,FtsK_SpoIIIE,Yop-YscD_cpl
REGS3_k127_6085142_1	1054860.KB913030_gene5158	4.559e-55	201.0	COG0399@1|root,COG0399@2|Bacteria,2GKD7@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the DegT DnrJ EryC1 family	-	-	2.6.1.106	ko:K13310	ko00523,ko01130,map00523,map01130	M00797	R06426	RC00006,RC01514	ko00000,ko00001,ko00002,ko01000	-	-	-	DegT_DnrJ_EryC1
REGS3_k127_6085142_0	1121406.JAEX01000001_gene467	4.755e-79	275.0	COG0451@1|root,COG0451@2|Bacteria,1MXKV@1224|Proteobacteria,42Q4Y@68525|delta/epsilon subdivisions,2WKZT@28221|Deltaproteobacteria,2M8BB@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	3-beta hydroxysteroid dehydrogenase/isomerase family	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
REGS3_k127_6085142_3	1206726.BAFV01000039_gene2720	1.515e-13	79.0	COG2197@1|root,COG2197@2|Bacteria,2GJ46@201174|Actinobacteria,4FWGU@85025|Nocardiaceae	201174|Actinobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
REGS3_k127_6085142_2	1068980.ARVW01000001_gene6886	9.425e-39	155.0	COG2197@1|root,COG2197@2|Bacteria,2GJ29@201174|Actinobacteria,4E4RN@85010|Pseudonocardiales	201174|Actinobacteria	KT	helix_turn_helix, Lux Regulon	-	-	-	ko:K07684	ko02020,map02020	M00471	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
REGS3_k127_6095818_2	2074.JNYD01000055_gene2319	6.551e-28	117.0	COG3795@1|root,COG3795@2|Bacteria,2IQMR@201174|Actinobacteria,4E69V@85010|Pseudonocardiales	201174|Actinobacteria	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
REGS3_k127_6095818_1	1122138.AQUZ01000015_gene6862	3.044e-115	383.0	COG4941@1|root,COG4941@2|Bacteria,2GJ36@201174|Actinobacteria,4DN3F@85009|Propionibacteriales	201174|Actinobacteria	K	PFAM sigma-70 region 2 domain protein	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
REGS3_k127_6095818_0	1313172.YM304_03440	1.566e-162	521.0	COG0024@1|root,COG0024@2|Bacteria,2GKIZ@201174|Actinobacteria,4CP59@84992|Acidimicrobiia	201174|Actinobacteria	J	Protein synonym peptidase M	map	GO:0000096,GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005506,GO:0006082,GO:0006464,GO:0006508,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0009066,GO:0009987,GO:0010467,GO:0016151,GO:0016485,GO:0016787,GO:0019538,GO:0019752,GO:0030145,GO:0035551,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0046872,GO:0046914,GO:0050897,GO:0051604,GO:0070006,GO:0070011,GO:0070084,GO:0071704,GO:0140096,GO:1901564,GO:1901605	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
REGS3_k127_6095818_4	882083.SacmaDRAFT_5298	2.685e-13	79.0	COG1261@1|root,COG1261@2|Bacteria,2HKN9@201174|Actinobacteria,4ED8H@85010|Pseudonocardiales	201174|Actinobacteria	NO	SAF	-	-	-	-	-	-	-	-	-	-	-	-	SAF
REGS3_k127_6095818_3	882083.SacmaDRAFT_5297	2.073e-16	88.0	COG0455@1|root,COG0455@2|Bacteria,2HT5K@201174|Actinobacteria,4DYHS@85010|Pseudonocardiales	201174|Actinobacteria	D	bacterial-type flagellum organization	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_6095818_5	1095767.CAHD01000203_gene2329	4.425e-11	67.0	COG4962@1|root,COG4962@2|Bacteria,2GKKJ@201174|Actinobacteria	201174|Actinobacteria	U	Type ii secretion system protein e	-	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
REGS3_k127_6107084_5	1380356.JNIK01000011_gene1669	8.104e-67	238.0	COG2141@1|root,COG2141@2|Bacteria,2GJ66@201174|Actinobacteria,4ESQA@85013|Frankiales	201174|Actinobacteria	C	TIGRFAM luciferase family oxidoreductase, group 1	limB_5	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
REGS3_k127_6107084_4	1157708.KB907451_gene4573	7.636e-85	290.0	COG0179@1|root,COG0179@2|Bacteria,1MUPF@1224|Proteobacteria,2VMWW@28216|Betaproteobacteria,4ABTA@80864|Comamonadaceae	28216|Betaproteobacteria	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
REGS3_k127_6107084_0	1313172.YM304_14220	1.24e-131	431.0	COG0003@1|root,COG0003@2|Bacteria,2GJYN@201174|Actinobacteria,4CN0P@84992|Acidimicrobiia	84992|Acidimicrobiia	P	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	ArsA_ATPase
REGS3_k127_6107084_2	1313172.YM304_14210	3.722e-105	350.0	COG0003@1|root,COG0003@2|Bacteria,2GJ0J@201174|Actinobacteria,4CN5H@84992|Acidimicrobiia	84992|Acidimicrobiia	P	Anion-transporting ATPase	-	-	-	-	-	-	-	-	-	-	-	-	ArsA_ATPase
REGS3_k127_6107084_3	1313172.YM304_34390	1.164e-86	289.0	COG1051@1|root,COG1051@2|Bacteria,2GJGZ@201174|Actinobacteria	201174|Actinobacteria	F	ADP-ribose pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4916
REGS3_k127_6107084_1	1313172.YM304_34380	8.866e-110	363.0	COG0266@1|root,COG0266@2|Bacteria,2GKCW@201174|Actinobacteria	201174|Actinobacteria	L	Glycosylase	nei	GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363	4.2.99.18	ko:K05522	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
REGS3_k127_6107084_6	215803.DB30_1490	1.343e-32	134.0	COG1572@1|root,COG1572@2|Bacteria	2|Bacteria	NU	bacterial-type flagellum-dependent cell motility	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,DUF3367,DUF5122,HemolysinCabind,NPCBM
REGS3_k127_6119399_7	487521.OCU_44310	2.912e-31	126.0	COG0243@1|root,COG0243@2|Bacteria,2I8HX@201174|Actinobacteria,232RY@1762|Mycobacteriaceae	201174|Actinobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
REGS3_k127_6119399_5	1366046.HIMB11_00642	2.887e-78	269.0	COG1028@1|root,COG1028@2|Bacteria,1MXTP@1224|Proteobacteria,2TQST@28211|Alphaproteobacteria,3ZGDT@58840|unclassified Rhodobacteraceae	28211|Alphaproteobacteria	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	1.1.1.175	ko:K22185	ko00040,map00040	-	R01429	RC00066	ko00000,ko00001,ko01000	-	-	-	adh_short_C2
REGS3_k127_6119399_2	1313172.YM304_22790	7.593e-149	482.0	COG0568@1|root,COG0568@2|Bacteria,2GK3Z@201174|Actinobacteria,4CMST@84992|Acidimicrobiia	201174|Actinobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	rpoD	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
REGS3_k127_6119399_1	1313172.YM304_22780	1.231e-256	804.0	COG0358@1|root,COG0358@2|Bacteria,2GJFX@201174|Actinobacteria,4CMWH@84992|Acidimicrobiia	84992|Acidimicrobiia	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,Toprim_4,Toprim_N,zf-CHC2
REGS3_k127_6119399_3	1313172.YM304_22760	1.045e-108	365.0	COG0861@1|root,COG0861@2|Bacteria,2GIWU@201174|Actinobacteria	201174|Actinobacteria	P	membrane protein terC	-	-	-	ko:K05794	-	-	-	-	ko00000	-	-	-	TerC
REGS3_k127_6119399_0	1313172.YM304_22750	0.0	1407.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2GK73@201174|Actinobacteria,4CMX0@84992|Acidimicrobiia	84992|Acidimicrobiia	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
REGS3_k127_6119399_4	1313172.YM304_22740	8.434e-86	298.0	COG1994@1|root,COG1994@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50,Peptidase_M50B
REGS3_k127_6119399_6	1313172.YM304_29280	6.543e-32	134.0	COG1403@1|root,COG1403@2|Bacteria	2|Bacteria	V	endonuclease activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
REGS3_k127_6129477_0	1313172.YM304_24460	0.0	1199.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,2GN09@201174|Actinobacteria,4CMR1@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Conserved region in glutamate synthase	-	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
REGS3_k127_6129477_7	1313172.YM304_19810	1.634e-47	186.0	COG1470@1|root,COG1470@2|Bacteria,2GP8D@201174|Actinobacteria,4CN8S@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Protein of unknown function (DUF3048) C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3048,DUF3048_C
REGS3_k127_6129477_1	1313172.YM304_24440	1.701e-124	403.0	COG1024@1|root,COG1024@2|Bacteria,2GKC4@201174|Actinobacteria	201174|Actinobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
REGS3_k127_6129477_2	1254432.SCE1572_04610	1.221e-105	353.0	COG2227@1|root,COG2227@2|Bacteria,1R67Q@1224|Proteobacteria	1224|Proteobacteria	H	Methyltransferase type 12	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_12,Methyltransf_25,Methyltransf_31
REGS3_k127_6129477_3	36809.MAB_3693c	1.595e-105	345.0	COG0778@1|root,COG0778@2|Bacteria,2HI8Q@201174|Actinobacteria,2335S@1762|Mycobacteriaceae	201174|Actinobacteria	C	nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
REGS3_k127_6129477_5	298654.FraEuI1c_3697	1.349e-58	214.0	COG2045@1|root,COG2045@2|Bacteria,2II0K@201174|Actinobacteria,4EVYF@85013|Frankiales	201174|Actinobacteria	H	Belongs to the ComB family	-	-	3.1.3.71	ko:K05979	ko00680,ko01120,map00680,map01120	M00358	R05789	RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	2-ph_phosp
REGS3_k127_6129477_4	68570.DC74_7874	1.671e-65	233.0	COG2320@1|root,COG2320@2|Bacteria,2IFSJ@201174|Actinobacteria	201174|Actinobacteria	H	GrpB protein	-	-	-	-	-	-	-	-	-	-	-	-	GrpB
REGS3_k127_6129477_6	547163.BN979_06139	5.967e-55	194.0	COG0346@1|root,COG0346@2|Bacteria,2GQZ9@201174|Actinobacteria,239D6@1762|Mycobacteriaceae	201174|Actinobacteria	E	Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
REGS3_k127_6129477_8	1313172.YM304_24400	3.418e-20	90.0	COG2188@1|root,COG2188@2|Bacteria,2HF8W@201174|Actinobacteria,4CN6C@84992|Acidimicrobiia	84992|Acidimicrobiia	K	UTRA	-	-	-	ko:K03710	-	-	-	-	ko00000,ko03000	-	-	-	GntR,UTRA
REGS3_k127_6129657_4	335543.Sfum_1521	1.989e-70	247.0	COG0730@1|root,COG0730@2|Bacteria,1MXNM@1224|Proteobacteria,42KZF@68525|delta/epsilon subdivisions,2WSRV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
REGS3_k127_6129657_0	196162.Noca_0969	5.808e-214	692.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
REGS3_k127_6129657_2	196162.Noca_0968	8.514e-98	327.0	COG1136@1|root,COG1136@2|Bacteria,2GJQV@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
REGS3_k127_6129657_3	439493.PB7211_871	4.834e-91	314.0	COG2175@1|root,COG2175@2|Bacteria,1MX7P@1224|Proteobacteria,2UR9W@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Protein of unknown function (DUF971)	-	-	-	-	-	-	-	-	-	-	-	-	DUF971,TauD
REGS3_k127_6129657_1	397278.JOJN01000007_gene3188	3.585e-104	344.0	COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria,4DTSK@85009|Propionibacteriales	201174|Actinobacteria	C	Aldehyde dehydrogenase family	-	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
REGS3_k127_6131005_9	649638.Trad_2612	2.355e-06	56.0	COG0739@1|root,COG0739@2|Bacteria,1WK9B@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	M	PFAM Peptidase family M23	-	-	-	ko:K21472	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
REGS3_k127_6131005_8	258533.BN977_04985	9.177e-45	169.0	COG2808@1|root,COG2808@2|Bacteria,2IEXV@201174|Actinobacteria,2391Z@1762|Mycobacteriaceae	201174|Actinobacteria	K	Putative FMN-binding domain	-	-	-	ko:K07734	-	-	-	-	ko00000,ko03000	-	-	-	FMN_bind_2
REGS3_k127_6131005_1	1229780.BN381_250091	1.177e-200	653.0	COG0308@1|root,COG0308@2|Bacteria,2GJJ4@201174|Actinobacteria,3UWD9@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	E	ERAP1-like C-terminal domain	pepN	-	3.4.11.2	ko:K01256,ko:K08776	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	ERAP1_C,Peptidase_M1
REGS3_k127_6131005_3	1313172.YM304_11110	1.941e-148	477.0	COG0524@1|root,COG0524@2|Bacteria,2HG91@201174|Actinobacteria,4CN70@84992|Acidimicrobiia	84992|Acidimicrobiia	G	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
REGS3_k127_6131005_0	1313172.YM304_11120	1.105e-200	640.0	COG1109@1|root,COG1109@2|Bacteria,2GJ3Q@201174|Actinobacteria	201174|Actinobacteria	G	phosphoglucomutase phosphomannomutase alpha beta alpha domain II	pmmB	-	5.4.2.2,5.4.2.8	ko:K01835,ko:K01840	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114,M00549	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
REGS3_k127_6131005_6	1313172.YM304_11150	2.246e-71	248.0	COG0035@1|root,COG0035@2|Bacteria,2GPJE@201174|Actinobacteria	201174|Actinobacteria	F	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate	upp	GO:0003674,GO:0003824,GO:0004849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043097,GO:0043174,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.2.9	ko:K00761	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000	-	-	-	UPRTase
REGS3_k127_6131005_2	1313172.YM304_11140	4.988e-176	571.0	COG1816@1|root,COG1816@2|Bacteria,2GJ6I@201174|Actinobacteria	201174|Actinobacteria	F	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism	add	GO:0003674,GO:0003824,GO:0004000,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006144,GO:0006152,GO:0006154,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009113,GO:0009116,GO:0009119,GO:0009163,GO:0009164,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017144,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042278,GO:0042440,GO:0042451,GO:0042454,GO:0042455,GO:0042737,GO:0043094,GO:0043096,GO:0043101,GO:0043103,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046085,GO:0046100,GO:0046101,GO:0046102,GO:0046103,GO:0046112,GO:0046128,GO:0046129,GO:0046130,GO:0046148,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0072523,GO:1901135,GO:1901136,GO:1901137,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901658,GO:1901659	3.5.4.4	ko:K01488	ko00230,ko01100,ko05340,map00230,map01100,map05340	-	R01560,R02556	RC00477	ko00000,ko00001,ko01000	-	-	iNJ661.Rv3313c	A_deaminase
REGS3_k127_6131005_4	1313172.YM304_11130	5.321e-129	425.0	COG5285@1|root,COG5285@2|Bacteria,2I96N@201174|Actinobacteria	201174|Actinobacteria	Q	Phytanoyl-CoA dioxygenase (PhyH)	-	-	1.14.11.18	ko:K00477,ko:K18565	ko00332,ko01130,ko04146,map00332,map01130,map04146	-	R10740,R10741,R10742	RC03267,RC03268,RC03269	ko00000,ko00001,ko01000	-	-	-	PhyH
REGS3_k127_6131005_7	1313172.YM304_11170	2.246e-53	192.0	COG0780@1|root,COG0780@2|Bacteria,2GS82@201174|Actinobacteria,4CNEJ@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)	queF	-	1.7.1.13	ko:K09457	ko00790,ko01100,map00790,map01100	-	R07605	RC01875	ko00000,ko00001,ko01000,ko03016	-	-	-	QueF
REGS3_k127_6131005_5	996637.SGM_0927	4.461e-121	400.0	COG1079@1|root,COG1079@2|Bacteria,2GKMB@201174|Actinobacteria	201174|Actinobacteria	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
REGS3_k127_6165935_1	1313172.YM304_15360	5.49e-136	438.0	COG2120@1|root,COG2120@2|Bacteria,2H2NY@201174|Actinobacteria,4CN0C@84992|Acidimicrobiia	84992|Acidimicrobiia	S	GlcNAc-PI de-N-acetylase	-	-	3.5.1.115	ko:K18455	-	-	-	-	ko00000,ko01000	-	-	-	PIG-L
REGS3_k127_6165935_7	1313172.YM304_15350	2.571e-29	130.0	COG1881@1|root,COG1881@2|Bacteria	2|Bacteria	S	positive regulation of acetylcholine metabolic process	-	-	-	ko:K06910	-	-	-	-	ko00000	-	-	-	PBP
REGS3_k127_6165935_2	313612.L8106_21924	2.285e-103	361.0	COG5001@1|root,COG5001@2|Bacteria,1G0SY@1117|Cyanobacteria,1H7TU@1150|Oscillatoriales	1117|Cyanobacteria	T	COGs COG5001 signal transduction protein containing a membrane domain an EAL and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF,GGDEF,PAS,PAS_3,PAS_4,PAS_9,Response_reg,SBP_bac_3,dCache_1
REGS3_k127_6165935_0	1313172.YM304_02870	8.873e-233	742.0	COG1960@1|root,COG1960@2|Bacteria,2GKQI@201174|Actinobacteria,4CNFX@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
REGS3_k127_6165935_9	1323361.JPOC01000008_gene3446	7.304e-24	115.0	2AQPD@1|root,31FWY@2|Bacteria,2HJK0@201174|Actinobacteria,4G6YZ@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_6165935_10	1229780.BN381_350150	1.83e-21	97.0	COG3536@1|root,COG3536@2|Bacteria,2HDP4@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF971)	-	-	-	-	-	-	-	-	-	-	-	-	DUF971
REGS3_k127_6165935_5	1313172.YM304_15320	2.178e-89	302.0	COG0705@1|root,COG0705@2|Bacteria,2GJYG@201174|Actinobacteria	201174|Actinobacteria	NU	Rhomboid family	gluP	-	3.4.21.105	ko:K19225	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Rhomboid,zf-B_box
REGS3_k127_6165935_4	316274.Haur_3716	6.136e-98	342.0	2DBVK@1|root,2ZBBH@2|Bacteria,2G7SF@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_6165935_6	1313172.YM304_14940	1.678e-55	200.0	COG1920@1|root,COG1920@2|Bacteria,2HGFR@201174|Actinobacteria,4CND9@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Guanylyl transferase CofC like	-	-	2.7.7.68	ko:K14941	ko00680,ko01120,map00680,map01120	M00378	R09397	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CofC
REGS3_k127_6165935_3	1313172.YM304_14930	1.879e-100	343.0	COG2120@1|root,COG2120@2|Bacteria,2IR6Y@201174|Actinobacteria,4CN50@84992|Acidimicrobiia	84992|Acidimicrobiia	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
REGS3_k127_6172013_11	1121377.KB906399_gene1911	2.667e-42	157.0	COG2041@1|root,COG2041@2|Bacteria,1WJB2@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	PFAM oxidoreductase, molybdopterin binding	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_molyb
REGS3_k127_6172013_14	29581.BW37_02469	1.493e-11	72.0	COG3468@1|root,COG4625@1|root,COG3468@2|Bacteria,COG4625@2|Bacteria,1QU2X@1224|Proteobacteria,2VHDJ@28216|Betaproteobacteria	28216|Betaproteobacteria	MU	TIGRFAM outer membrane autotransporter barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Autotransporter,He_PIG,TIG
REGS3_k127_6172013_9	1121877.JQKF01000016_gene162	1.596e-45	173.0	COG2345@1|root,COG2345@2|Bacteria,2HGTI@201174|Actinobacteria,4CNV8@84992|Acidimicrobiia	84992|Acidimicrobiia	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
REGS3_k127_6172013_0	1313172.YM304_09730	1.055e-195	615.0	COG0489@1|root,COG2151@1|root,COG0489@2|Bacteria,COG2151@2|Bacteria,2GJUZ@201174|Actinobacteria,4CMV4@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	-	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	ParA
REGS3_k127_6172013_8	1313172.YM304_09760	1.557e-90	306.0	COG0693@1|root,COG0693@2|Bacteria,2H6FV@201174|Actinobacteria	201174|Actinobacteria	S	ThiJ PfpI	-	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI
REGS3_k127_6172013_7	675635.Psed_0387	9.647e-102	342.0	COG4977@1|root,COG4977@2|Bacteria,2GM0M@201174|Actinobacteria,4E1BX@85010|Pseudonocardiales	201174|Actinobacteria	K	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain	-	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009405,GO:0010468,GO:0010565,GO:0016020,GO:0019216,GO:0019217,GO:0019222,GO:0031323,GO:0044419,GO:0044464,GO:0050789,GO:0050794,GO:0051704,GO:0060255,GO:0062012,GO:0065007,GO:0071944,GO:0080090	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI,HTH_18
REGS3_k127_6172013_13	1313172.YM304_09820	2.412e-21	96.0	2E3M2@1|root,31DE4@2|Bacteria,2HH0X@201174|Actinobacteria,4CP16@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Protein of unknown function (DUF3107)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3107
REGS3_k127_6172013_5	1313172.YM304_09830	9.462e-118	386.0	COG0003@1|root,COG0003@2|Bacteria,2GJ0J@201174|Actinobacteria,4CMZD@84992|Acidimicrobiia	84992|Acidimicrobiia	P	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	ArsA_ATPase
REGS3_k127_6172013_3	1313172.YM304_09840	1.301e-145	474.0	COG0003@1|root,COG0003@2|Bacteria,2GJYN@201174|Actinobacteria,4CMZ2@84992|Acidimicrobiia	84992|Acidimicrobiia	D	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	ArsA_ATPase
REGS3_k127_6172013_1	1313172.YM304_09850	1.817e-190	607.0	COG3920@1|root,COG3920@2|Bacteria,2GKMP@201174|Actinobacteria,4CMRV@84992|Acidimicrobiia	84992|Acidimicrobiia	T	Histidine kinase	-	-	2.7.13.3	ko:K00936	-	M00839	-	-	ko00000,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,H_kinase_N,HisKA_2
REGS3_k127_6172013_12	1313172.YM304_09880	1.763e-33	131.0	2CC1Y@1|root,331E8@2|Bacteria,2HGFA@201174|Actinobacteria,4CNY6@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA	-	-	-	ko:K18955	-	-	-	-	ko00000,ko03000	-	-	-	Whib
REGS3_k127_6172013_10	1313172.YM304_09890	3.648e-44	169.0	COG0584@1|root,COG0584@2|Bacteria	2|Bacteria	C	glycerophosphodiester phosphodiesterase activity	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
REGS3_k127_6172013_4	1313172.YM304_09900	5.462e-138	447.0	COG1597@1|root,COG1597@2|Bacteria,2HH1A@201174|Actinobacteria,4CP1H@84992|Acidimicrobiia	2|Bacteria	G	Diacylglycerol kinase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
REGS3_k127_6172013_6	1313172.YM304_09910	1.345e-117	382.0	COG2086@1|root,COG2086@2|Bacteria,2GKV6@201174|Actinobacteria,4CMXI@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Electron transfer flavoprotein domain	-	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
REGS3_k127_6172013_2	1313172.YM304_09920	1.949e-152	487.0	COG2025@1|root,COG2025@2|Bacteria,2GJWH@201174|Actinobacteria,4CMXZ@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Electron transfer flavoprotein domain	etfA	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
REGS3_k127_6176543_1	1313172.YM304_21410	5.036e-52	188.0	COG0539@1|root,COG0539@2|Bacteria,2GJAK@201174|Actinobacteria,4CMW4@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Ribosomal protein S1-like RNA-binding domain	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
REGS3_k127_6176543_0	1229780.BN381_430006	8.648e-64	227.0	COG2197@1|root,COG2197@2|Bacteria,2GJRY@201174|Actinobacteria,3UWZH@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	K	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain	narL	-	-	ko:K07684	ko02020,map02020	M00471	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
REGS3_k127_6176543_3	1229780.BN381_70068	2.121e-49	201.0	COG3850@1|root,COG3850@2|Bacteria	2|Bacteria	T	phosphorelay sensor kinase activity	-	-	2.7.13.3	ko:K03406,ko:K07673,ko:K07675	ko02020,ko02030,map02020,map02030	M00471,M00473	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	GAF_2,HAMP,HATPase_c,HisKA_3,LapD_MoxY_N
REGS3_k127_6176543_2	1229780.BN381_430004	3.066e-51	190.0	COG0237@1|root,COG0237@2|Bacteria,2GN96@201174|Actinobacteria,3UWS8@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	H	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	GO:0000166,GO:0001882,GO:0001884,GO:0002135,GO:0003674,GO:0003824,GO:0004140,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0018130,GO:0019103,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032549,GO:0032551,GO:0032552,GO:0032553,GO:0032554,GO:0032557,GO:0032558,GO:0032564,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CoaE,GrpB
REGS3_k127_6183841_12	859657.RPSI07_mp0336	4.342e-42	171.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,1KC61@119060|Burkholderiaceae	28216|Betaproteobacteria	T	signal transduction protein eal-ggdef domains	-	-	2.1.1.80,3.1.1.61	ko:K13924	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,CheR,CheR_N,EAL,GAF_2,GGDEF,PAS,PAS_4,PAS_9
REGS3_k127_6183841_4	1429046.RR21198_2695	1.067e-95	336.0	COG0008@1|root,COG0008@2|Bacteria,2GKMT@201174|Actinobacteria,4FVXF@85025|Nocardiaceae	201174|Actinobacteria	J	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon	gluQ	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
REGS3_k127_6183841_14	6211.A0A068Y4T3	2.731e-08	64.0	KOG1971@1|root,KOG1971@2759|Eukaryota,38DIW@33154|Opisthokonta,3BCUS@33208|Metazoa,3CS3C@33213|Bilateria	33208|Metazoa	O	procollagen-lysine 5-dioxygenase activity	PLOD1	GO:0000003,GO:0000902,GO:0000904,GO:0001666,GO:0001701,GO:0001885,GO:0001886,GO:0002009,GO:0002064,GO:0003006,GO:0003008,GO:0003013,GO:0003018,GO:0003158,GO:0003382,GO:0003674,GO:0003824,GO:0003980,GO:0005488,GO:0005506,GO:0005515,GO:0005575,GO:0005576,GO:0005615,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005789,GO:0005791,GO:0005794,GO:0005802,GO:0006011,GO:0006082,GO:0006139,GO:0006464,GO:0006486,GO:0006493,GO:0006520,GO:0006575,GO:0006725,GO:0006793,GO:0006807,GO:0006950,GO:0007275,GO:0007276,GO:0007281,GO:0007292,GO:0007295,GO:0007399,GO:0008015,GO:0008104,GO:0008150,GO:0008152,GO:0008194,GO:0008198,GO:0008378,GO:0008475,GO:0008544,GO:0008652,GO:0009058,GO:0009059,GO:0009066,GO:0009067,GO:0009100,GO:0009101,GO:0009225,GO:0009628,GO:0009653,GO:0009719,GO:0009725,GO:0009790,GO:0009792,GO:0009887,GO:0009888,GO:0009987,GO:0010033,GO:0012505,GO:0016020,GO:0016043,GO:0016053,GO:0016491,GO:0016705,GO:0016706,GO:0016740,GO:0016757,GO:0016758,GO:0017185,GO:0018126,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0019842,GO:0019953,GO:0021915,GO:0022412,GO:0022414,GO:0022607,GO:0030154,GO:0030198,GO:0030199,GO:0030246,GO:0030323,GO:0030324,GO:0030855,GO:0030867,GO:0031012,GO:0031090,GO:0031406,GO:0031418,GO:0031984,GO:0032501,GO:0032502,GO:0032504,GO:0032870,GO:0032963,GO:0032964,GO:0032989,GO:0032991,GO:0033036,GO:0033218,GO:0033823,GO:0034641,GO:0034645,GO:0035150,GO:0035250,GO:0035251,GO:0035295,GO:0035296,GO:0036094,GO:0036211,GO:0036293,GO:0040007,GO:0042175,GO:0042221,GO:0042277,GO:0042311,GO:0042398,GO:0042802,GO:0042803,GO:0043009,GO:0043062,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0043413,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044283,GO:0044421,GO:0044422,GO:0044424,GO:0044425,GO:0044431,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0044703,GO:0045446,GO:0046394,GO:0046483,GO:0046527,GO:0046872,GO:0046914,GO:0046946,GO:0046947,GO:0046983,GO:0048029,GO:0048037,GO:0048468,GO:0048471,GO:0048477,GO:0048513,GO:0048589,GO:0048609,GO:0048729,GO:0048730,GO:0048731,GO:0048856,GO:0048869,GO:0050211,GO:0050662,GO:0050880,GO:0050896,GO:0051179,GO:0051213,GO:0051704,GO:0051716,GO:0055086,GO:0055114,GO:0060425,GO:0060429,GO:0060541,GO:0062023,GO:0065007,GO:0065008,GO:0070085,GO:0070482,GO:0070815,GO:0070831,GO:0070887,GO:0071310,GO:0071495,GO:0071704,GO:0071711,GO:0071840,GO:0090066,GO:0097359,GO:0097435,GO:0097746,GO:0097755,GO:0098588,GO:0098791,GO:0098827,GO:0140096,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	1.14.11.4,2.4.1.50,2.4.1.66	ko:K00473,ko:K13645,ko:K13646,ko:K13647,ko:K15174	ko00310,ko00514,ko04011,map00310,map00514,map04011	-	R03376,R03380,R04491	RC00005,RC00049,RC00397,RC00709	ko00000,ko00001,ko01000,ko01003,ko03021,ko04147	-	-	-	2OG-FeII_Oxy
REGS3_k127_6183841_7	1313172.YM304_02380	5.019e-91	310.0	COG1376@1|root,COG3409@1|root,COG1376@2|Bacteria,COG3409@2|Bacteria,2GXGF@201174|Actinobacteria	201174|Actinobacteria	M	ErfK YbiS YcfS YnhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1,YkuD
REGS3_k127_6183841_0	1313172.YM304_02390	0.0	1176.0	COG3250@1|root,COG3250@2|Bacteria,2GMAT@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase 2 family	-	-	3.2.1.23	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	-	R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000	-	-	-	Bgal_small_N,DUF4981,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
REGS3_k127_6183841_1	1313172.YM304_02440	1.278e-222	700.0	COG2146@1|root,COG2220@1|root,COG2146@2|Bacteria,COG2220@2|Bacteria,2GP4N@201174|Actinobacteria	201174|Actinobacteria	P	Rieske 2Fe-2S	-	-	-	ko:K14952	ko05152,map05152	-	-	-	ko00000,ko00001	-	-	-	Lactamase_B_3,Rieske
REGS3_k127_6183841_13	1313172.YM304_02450	2.391e-16	87.0	2DH1Q@1|root,2ZY32@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF2510)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2510
REGS3_k127_6183841_9	1313172.YM304_02460	4.733e-76	281.0	COG1131@1|root,COG1131@2|Bacteria,2IJGC@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	ccmA	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
REGS3_k127_6183841_10	512565.AMIS_5810	7.913e-74	258.0	COG2897@1|root,COG2897@2|Bacteria,2GMDR@201174|Actinobacteria,4D93S@85008|Micromonosporales	201174|Actinobacteria	P	Rhodanese domain protein	-	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
REGS3_k127_6183841_8	1123024.AUII01000034_gene2688	1.462e-81	289.0	COG1641@1|root,COG1641@2|Bacteria,2I8J1@201174|Actinobacteria,4E10F@85010|Pseudonocardiales	201174|Actinobacteria	S	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes	larC	-	4.99.1.12	ko:K09121	-	-	-	-	ko00000,ko01000	-	-	-	DUF111
REGS3_k127_6183841_11	936589.HMPREF1521_1025	1.554e-58	216.0	COG1691@1|root,COG1691@2|Bacteria,1TP0Z@1239|Firmicutes,4H3XI@909932|Negativicutes	909932|Negativicutes	S	AIR carboxylase	-	-	-	ko:K06898	-	-	-	-	ko00000	-	-	-	AIRC
REGS3_k127_6183841_2	1313172.YM304_02490	6.537e-146	467.0	COG0077@1|root,COG0077@2|Bacteria,2GJQ5@201174|Actinobacteria,4CN0G@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Prephenate dehydratase	pheA	-	4.2.1.51	ko:K04518	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024	R00691,R01373	RC00360	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,PDT
REGS3_k127_6183841_5	1313172.YM304_36230	2.031e-93	311.0	COG0745@1|root,COG0745@2|Bacteria,2HG0R@201174|Actinobacteria,4CNMQ@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Transcriptional regulatory protein, C terminal	-	-	-	ko:K07669	ko02020,map02020	M00460	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
REGS3_k127_6183841_6	749414.SBI_02086	2.989e-92	320.0	COG0642@1|root,COG2205@2|Bacteria,2GM17@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K07653	ko02020,map02020	M00460	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
REGS3_k127_6188768_0	1313172.YM304_26450	3.777e-253	804.0	COG1123@1|root,COG4172@2|Bacteria,2H3HY@201174|Actinobacteria,4CP5D@84992|Acidimicrobiia	84992|Acidimicrobiia	P	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
REGS3_k127_6188768_4	1380391.JIAS01000004_gene2985	2.021e-88	304.0	COG1173@1|root,COG1173@2|Bacteria,1R7UQ@1224|Proteobacteria,2U4Q2@28211|Alphaproteobacteria,2JV9K@204441|Rhodospirillales	204441|Rhodospirillales	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
REGS3_k127_6188768_5	196367.JNFG01000019_gene4406	4.817e-78	272.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2W255@28216|Betaproteobacteria,1K530@119060|Burkholderiaceae	28216|Betaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
REGS3_k127_6188768_3	1313172.YM304_26480	1.739e-118	402.0	COG0747@1|root,COG0747@2|Bacteria	2|Bacteria	E	dipeptide transport	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
REGS3_k127_6188768_1	1229780.BN381_80311	1.393e-176	559.0	COG0468@1|root,COG0468@2|Bacteria,2GJ4P@201174|Actinobacteria,3UW96@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	GO:0000150,GO:0000166,GO:0000287,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009432,GO:0009605,GO:0009628,GO:0009650,GO:0009987,GO:0009991,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030145,GO:0030554,GO:0031668,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0042148,GO:0042221,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046677,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
REGS3_k127_6188768_8	1313172.YM304_27070	2.244e-20	97.0	COG5349@1|root,COG5349@2|Bacteria,2HCSH@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF983)	-	-	-	-	-	-	-	-	-	-	-	-	DUF983
REGS3_k127_6188768_2	367299.JOEE01000004_gene1045	5.451e-129	428.0	COG0001@1|root,COG0001@2|Bacteria,2GJSH@201174|Actinobacteria,4FFWW@85021|Intrasporangiaceae	201174|Actinobacteria	H	Aminotransferase class-III	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
REGS3_k127_6188768_9	1121355.KB903379_gene760	0.000213	46.0	COG2510@1|root,COG2510@2|Bacteria,2HW2B@201174|Actinobacteria,22Q8K@1653|Corynebacteriaceae	201174|Actinobacteria	S	EamA-like transporter family	-	-	-	ko:K08978	-	-	-	-	ko00000,ko02000	2.A.7.2	-	-	EamA
REGS3_k127_6188768_7	1172188.KB911820_gene2125	4.266e-32	143.0	COG2372@1|root,COG2372@2|Bacteria,2GMKG@201174|Actinobacteria,4FHI6@85021|Intrasporangiaceae	201174|Actinobacteria	P	CopC domain	copC	-	-	ko:K07156,ko:K14166	-	-	-	-	ko00000,ko02000	9.B.62.2	-	-	CopC
REGS3_k127_6209457_3	1313172.YM304_39200	8.93e-105	344.0	COG0443@1|root,COG0443@2|Bacteria,2GJTY@201174|Actinobacteria,4CMVI@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
REGS3_k127_6209457_6	1313172.YM304_39190	9.153e-39	151.0	COG0576@1|root,COG0576@2|Bacteria,2HGAI@201174|Actinobacteria,4CN9N@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
REGS3_k127_6209457_2	525909.Afer_1962	8.779e-118	389.0	COG0484@1|root,COG0484@2|Bacteria,2GJKK@201174|Actinobacteria,4CMRG@84992|Acidimicrobiia	84992|Acidimicrobiia	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	-	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
REGS3_k127_6209457_5	1313172.YM304_39170	1.112e-39	152.0	COG0789@1|root,COG0789@2|Bacteria,2GR1T@201174|Actinobacteria,4CN4Z@84992|Acidimicrobiia	84992|Acidimicrobiia	K	helix_turn_helix, mercury resistance	-	-	-	ko:K13640	-	-	-	-	ko00000,ko03000	-	-	-	MerR_1
REGS3_k127_6209457_7	1313172.YM304_39050	4.637e-23	110.0	COG4279@1|root,COG4279@2|Bacteria	2|Bacteria	S	zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	DUF3670,Helicase_C,SNF2_N,SWIM
REGS3_k127_6209457_1	994479.GL877878_gene2540	5.369e-188	622.0	COG0553@1|root,COG0553@2|Bacteria,2GISC@201174|Actinobacteria,4DX3H@85010|Pseudonocardiales	201174|Actinobacteria	L	SNF2 family N-terminal domain	helZ	-	-	-	-	-	-	-	-	-	-	-	DUF3670,Helicase_C,SNF2_N
REGS3_k127_6209457_4	1313172.YM304_39060	8.266e-66	234.0	COG0561@1|root,COG0561@2|Bacteria,2GP42@201174|Actinobacteria,4CND4@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Sucrose-6F-phosphate phosphohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3
REGS3_k127_6209457_0	1313172.YM304_39000	0.0	1219.0	COG0542@1|root,COG0542@2|Bacteria,2GJ73@201174|Actinobacteria,4CMTX@84992|Acidimicrobiia	84992|Acidimicrobiia	O	C-terminal, D2-small domain, of ClpB protein	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
REGS3_k127_6221357_2	1122609.AUGT01000009_gene3066	1.815e-58	205.0	COG1487@1|root,COG1487@2|Bacteria,2IMGJ@201174|Actinobacteria,4DR9D@85009|Propionibacteriales	201174|Actinobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0006139,GO:0006417,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016070,GO:0016787,GO:0016788,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360,GO:2000112,GO:2000113	-	-	-	-	-	-	-	-	-	-	PIN
REGS3_k127_6221357_3	426716.JOAJ01000005_gene2844	7.971e-06	50.0	2B5X5@1|root,31YT4@2|Bacteria,2I06K@201174|Actinobacteria,4G515@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_6221357_0	1313172.YM304_32970	3.807e-173	550.0	COG0012@1|root,COG0012@2|Bacteria,2GIXI@201174|Actinobacteria,4CMT9@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Protein of unknown function (DUF933)	-	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
REGS3_k127_6221357_1	1394178.AWOO02000093_gene8076	3.479e-115	379.0	COG1387@1|root,COG1387@2|Bacteria,2GMFH@201174|Actinobacteria,4EGUG@85012|Streptosporangiales	201174|Actinobacteria	E	Helix-hairpin-helix domain	polX	-	-	ko:K04477	-	-	-	-	ko00000	-	-	-	HHH_8,PHP
REGS3_k127_6221473_9	446470.Snas_2215	1.838e-81	278.0	COG0581@1|root,COG0581@2|Bacteria,2I2F2@201174|Actinobacteria,4EXVJ@85014|Glycomycetales	201174|Actinobacteria	P	Binding-protein-dependent transport system inner membrane component	pstA	GO:0008150,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044403,GO:0044419,GO:0051704	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
REGS3_k127_6221473_5	446470.Snas_2214	3.861e-107	357.0	COG1117@1|root,COG1117@2|Bacteria,2GJQ3@201174|Actinobacteria,4EXWB@85014|Glycomycetales	201174|Actinobacteria	P	ATPases associated with a variety of cellular activities	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
REGS3_k127_6221473_11	101510.RHA1_ro04980	1.292e-65	239.0	COG0300@1|root,COG0300@2|Bacteria,2I64P@201174|Actinobacteria,4FYJZ@85025|Nocardiaceae	201174|Actinobacteria	S	KR domain	-	-	-	ko:K07124	-	-	-	-	ko00000	-	-	-	adh_short
REGS3_k127_6221473_14	211114.JOEF01000022_gene5650	1.182e-26	122.0	COG1576@1|root,COG1576@2|Bacteria	2|Bacteria	J	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA	rlmH	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042802,GO:0042803,GO:0043021,GO:0043022,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0044877,GO:0046483,GO:0046983,GO:0070037,GO:0070038,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.177	ko:K00783	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SPOUT_MTase
REGS3_k127_6221473_1	1313172.YM304_04990	1.65e-180	592.0	COG2844@1|root,COG2844@2|Bacteria,2GMKT@201174|Actinobacteria	201174|Actinobacteria	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen	glnD	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008773,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0030312,GO:0044464,GO:0070566,GO:0070569,GO:0071944,GO:0140096	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	ACT,GlnD_UR_UTase,HD,NTP_transf_2
REGS3_k127_6221473_13	452652.KSE_23320	6.325e-46	168.0	COG0347@1|root,COG0347@2|Bacteria,2IKN1@201174|Actinobacteria,2M3NY@2063|Kitasatospora	201174|Actinobacteria	K	Nitrogen regulatory protein P-II	glnB	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0008144,GO:0008150,GO:0016020,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043531,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0051704,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K04751	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
REGS3_k127_6221473_3	1229780.BN381_150105	1.552e-159	512.0	COG0004@1|root,COG0004@2|Bacteria,2GIZK@201174|Actinobacteria,3UW7B@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	P	Ammonium Transporter Family	amt	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	iNJ661.Rv2920c	Ammonium_transp
REGS3_k127_6221473_2	471852.Tcur_3772	7.4e-168	540.0	COG2124@1|root,COG2124@2|Bacteria,2GKCG@201174|Actinobacteria,4EMQB@85012|Streptosporangiales	201174|Actinobacteria	Q	Cytochrome P450	cyp108B4	-	-	-	-	-	-	-	-	-	-	-	p450
REGS3_k127_6221473_0	1211815.CBYP010000067_gene115	1.441e-205	646.0	COG1960@1|root,COG1960@2|Bacteria,2GKQI@201174|Actinobacteria,4ETRJ@85013|Frankiales	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	fadE1_1	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
REGS3_k127_6221473_16	1050201.KB913034_gene1355	2.408e-10	67.0	COG2768@1|root,COG2768@2|Bacteria	2|Bacteria	-	-	fdxB	GO:0003674,GO:0003824,GO:0005488,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016491,GO:0022900,GO:0044237,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114	-	-	-	-	-	-	-	-	-	-	Fer4
REGS3_k127_6221473_15	562970.Btus_2701	2.038e-10	70.0	2BZG6@1|root,2ZH9N@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_6221473_8	525368.HMPREF0591_0025	4.349e-83	289.0	COG0425@1|root,COG0425@2|Bacteria,2I4E3@201174|Actinobacteria,23B3Y@1762|Mycobacteriaceae	201174|Actinobacteria	O	Belongs to the sulfur carrier protein TusA family	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_6221473_10	105422.BBPM01000016_gene2250	2.358e-68	237.0	COG0386@1|root,COG0386@2|Bacteria,2IFJH@201174|Actinobacteria,2NHJ7@228398|Streptacidiphilus	201174|Actinobacteria	O	Glutathione peroxidase	btuE	-	1.11.1.9	ko:K00432	ko00480,ko00590,ko04918,map00480,map00590,map04918	-	R00274,R07034,R07035	RC00011,RC00982	ko00000,ko00001,ko01000	-	-	-	GSHPx
REGS3_k127_6221473_4	358823.DF19_14495	1.392e-134	435.0	COG0596@1|root,COG0596@2|Bacteria,2GNBX@201174|Actinobacteria	201174|Actinobacteria	I	Belongs to the peptidase S33 family	-	-	3.4.11.5	ko:K01259	ko00330,map00330	-	R00135	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Abhydrolase_1
REGS3_k127_6221473_6	1120949.KB903294_gene3836	5.384e-90	303.0	COG2513@1|root,COG2513@2|Bacteria,2GMQ4@201174|Actinobacteria,4DEP9@85008|Micromonosporales	201174|Actinobacteria	G	Phosphoenolpyruvate phosphomutase	-	-	-	-	-	-	-	-	-	-	-	-	PEP_mutase
REGS3_k127_6221473_7	219305.MCAG_01063	5.112e-88	301.0	COG1718@1|root,COG1718@2|Bacteria,2GM3J@201174|Actinobacteria,4D90V@85008|Micromonosporales	201174|Actinobacteria	DT	Serine threonine protein kinase involved in cell cycle control	-	-	2.7.11.1	ko:K07178	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko01001,ko03009	-	-	-	RIO1
REGS3_k127_6221473_12	1122927.KB895420_gene4206	1.508e-57	203.0	2AKGE@1|root,31B89@2|Bacteria,1TYK3@1239|Firmicutes,4I7QK@91061|Bacilli,26X6P@186822|Paenibacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_6238857_3	1229780.BN381_10328	9.984e-91	317.0	COG1020@1|root,COG1020@2|Bacteria,2HEFF@201174|Actinobacteria,3UX6E@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	Q	Protein of unknown function (DUF1298)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1298,WES_acyltransf
REGS3_k127_6238857_2	1435356.Y013_16795	4.52e-114	385.0	COG1020@1|root,COG1020@2|Bacteria,2GKU0@201174|Actinobacteria,4FXE2@85025|Nocardiaceae	201174|Actinobacteria	Q	Protein of unknown function (DUF1298)	-	-	2.3.1.20	ko:K00635	ko00561,ko01100,map00561,map01100	M00089	R02251	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1298,WES_acyltransf
REGS3_k127_6238857_10	350058.Mvan_4029	2.486e-38	151.0	COG2761@1|root,COG2761@2|Bacteria,2HWM3@201174|Actinobacteria,237V9@1762|Mycobacteriaceae	201174|Actinobacteria	Q	dithiol-disulfide isomerase involved in polyketide biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	DSBA
REGS3_k127_6238857_6	1229780.BN381_130053	3.848e-80	274.0	COG2872@1|root,COG2872@2|Bacteria,2I8P6@201174|Actinobacteria	201174|Actinobacteria	S	Threonyl alanyl tRNA synthetase SAD	-	-	-	ko:K07050	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA-synt_2c,tRNA_SAD
REGS3_k127_6238857_11	1172188.KB911820_gene3040	6.406e-30	124.0	COG1576@1|root,COG3631@1|root,COG1576@2|Bacteria,COG3631@2|Bacteria,2IGAN@201174|Actinobacteria,4FG5C@85021|Intrasporangiaceae	201174|Actinobacteria	J	Mycothiol maleylpyruvate isomerase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_N
REGS3_k127_6238857_9	644548.SCNU_07953	2.053e-40	152.0	2C82G@1|root,32RK9@2|Bacteria,2IRVD@201174|Actinobacteria,4GGRZ@85026|Gordoniaceae	201174|Actinobacteria	S	Protein of unknown function (DUF4242)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4242
REGS3_k127_6238857_1	1380386.JIAW01000013_gene2501	2.221e-133	435.0	COG2207@1|root,COG2207@2|Bacteria,2GJDC@201174|Actinobacteria,23EX1@1762|Mycobacteriaceae	201174|Actinobacteria	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_6,HTH_18
REGS3_k127_6238857_0	497964.CfE428DRAFT_4885	6.034e-138	457.0	COG2152@1|root,COG2152@2|Bacteria,46S8T@74201|Verrucomicrobia	74201|Verrucomicrobia	G	beta-1,4-mannooligosaccharide phosphorylase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_130
REGS3_k127_6238857_5	479433.Caci_7699	5.227e-83	284.0	COG0561@1|root,COG0561@2|Bacteria,2HZD0@201174|Actinobacteria	201174|Actinobacteria	T	HAD hydrolase, family IIB	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3,PMM
REGS3_k127_6238857_12	1320556.AVBP01000009_gene2469	3.094e-27	117.0	COG0454@1|root,COG0454@2|Bacteria	2|Bacteria	K	-acetyltransferase	yrkN	-	2.3.1.82	ko:K03826,ko:K03827,ko:K18816	-	-	-	-	br01600,ko00000,ko01000,ko01504	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_7
REGS3_k127_6238857_7	1313172.YM304_05060	1.826e-63	228.0	COG1413@1|root,COG1413@2|Bacteria,2HA0J@201174|Actinobacteria,4CNCY@84992|Acidimicrobiia	84992|Acidimicrobiia	C	PBS lyase HEAT-like repeat	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
REGS3_k127_6238857_8	1313172.YM304_05080	3.086e-63	233.0	COG3480@1|root,COG3480@2|Bacteria,2GJDD@201174|Actinobacteria	201174|Actinobacteria	T	Belongs to the peptidase S16 family	ylbL	-	-	ko:K07177	ko02024,map02024	-	-	-	ko00000,ko00001,ko01002	-	-	-	Lon_C,PDZ_2
REGS3_k127_6238857_4	1313172.YM304_05090	3.032e-88	307.0	COG3599@1|root,COG3599@2|Bacteria	2|Bacteria	D	regulation of cell shape	-	-	-	ko:K04074	-	-	-	-	ko00000,ko03036	-	-	-	DivIVA
REGS3_k127_6256040_6	479432.Sros_2441	3.104e-27	114.0	COG3631@1|root,COG3631@2|Bacteria,2ISRH@201174|Actinobacteria	201174|Actinobacteria	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
REGS3_k127_6256040_3	1313172.YM304_42120	7.088e-101	340.0	COG0667@1|root,COG0667@2|Bacteria,2GMNA@201174|Actinobacteria,4CMQW@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
REGS3_k127_6256040_5	298655.KI912267_gene7911	1.315e-71	257.0	COG0604@1|root,COG0604@2|Bacteria,2GN47@201174|Actinobacteria,4ERXU@85013|Frankiales	201174|Actinobacteria	C	PFAM Alcohol dehydrogenase zinc-binding domain protein	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
REGS3_k127_6256040_1	1313172.YM304_39910	3.819e-135	442.0	COG0715@1|root,COG0715@2|Bacteria,2I93G@201174|Actinobacteria	201174|Actinobacteria	P	NMT1/THI5 like	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
REGS3_k127_6256040_2	1313172.YM304_39920	8.3e-102	345.0	COG0600@1|root,COG0600@2|Bacteria,2GKKZ@201174|Actinobacteria	201174|Actinobacteria	P	ABC-type nitrate sulfonate bicarbonate transport system permease component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
REGS3_k127_6256040_4	1313172.YM304_39930	1.308e-98	335.0	COG1116@1|root,COG1116@2|Bacteria,2GN33@201174|Actinobacteria,4CN3G@84992|Acidimicrobiia	201174|Actinobacteria	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
REGS3_k127_6256040_8	65071.PYU1_T000054	3.393e-07	61.0	COG0684@1|root,2RZ5Y@2759|Eukaryota,1MBD9@121069|Pythiales	121069|Pythiales	H	Aldolase/RraA	-	-	-	-	-	-	-	-	-	-	-	-	RraA-like,zf-BED
REGS3_k127_6256040_0	1313172.YM304_42220	3.549e-182	580.0	COG4638@1|root,COG4638@2|Bacteria,2GKJY@201174|Actinobacteria	201174|Actinobacteria	P	Rieske 2Fe-2S	-	-	-	ko:K00479	-	-	-	-	ko00000	-	-	-	Rieske,Ring_hydroxyl_A
REGS3_k127_6256040_7	1313172.YM304_42230	8.699e-14	72.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria	201174|Actinobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.48	ko:K02182	-	-	-	-	ko00000,ko01000	-	-	-	AMP-binding,AMP-binding_C
REGS3_k127_6288265_3	1313172.YM304_00860	9.621e-42	156.0	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
REGS3_k127_6288265_0	2074.JNYD01000002_gene5631	1.289e-78	266.0	2C3KP@1|root,2Z802@2|Bacteria,2IFTZ@201174|Actinobacteria,4E3VK@85010|Pseudonocardiales	201174|Actinobacteria	S	phage tail protein	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_6288265_2	234621.RER_34190	7.96e-43	165.0	COG4635@1|root,COG4635@2|Bacteria,2IQCQ@201174|Actinobacteria,4G0EJ@85025|Nocardiaceae	201174|Actinobacteria	CH	Flavodoxin domain	-	-	1.3.5.3	ko:K00230	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R09489	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavodoxin_5
REGS3_k127_6288265_1	1173024.KI912148_gene3847	2.034e-50	190.0	COG0317@1|root,COG0317@2|Bacteria,1G0F8@1117|Cyanobacteria,1JKIF@1189|Stigonemataceae	1117|Cyanobacteria	KT	HD domain	-	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	HD_4
REGS3_k127_6292529_2	1336243.JAEA01000001_gene1664	3.465e-69	238.0	COG3576@1|root,COG3576@2|Bacteria,1MWG9@1224|Proteobacteria,2TSKK@28211|Alphaproteobacteria,1JUQS@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	PFAM Pyridoxamine 5'-phosphate	MA20_21430	-	-	ko:K07006	-	-	-	-	ko00000	-	-	-	Putative_PNPOx
REGS3_k127_6292529_1	383372.Rcas_0264	1.638e-90	316.0	COG5184@1|root,COG5184@2|Bacteria,2G8WU@200795|Chloroflexi,3765G@32061|Chloroflexia	32061|Chloroflexia	DZ	PFAM regulator of chromosome condensation, RCC1	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_6292529_0	1197130.BAFM01000017_gene2644	6.447e-266	839.0	COG3119@1|root,arCOG02791@2157|Archaea,2Y8G8@28890|Euryarchaeota,23VJY@183963|Halobacteria	183963|Halobacteria	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
REGS3_k127_6292529_3	1283299.AUKG01000002_gene5276	9.663e-16	79.0	COG2141@1|root,COG2141@2|Bacteria,2GJ6T@201174|Actinobacteria,4CR0F@84995|Rubrobacteria	84995|Rubrobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
REGS3_k127_6343775_2	1463856.JOHY01000044_gene4175	1.757e-07	62.0	COG0392@1|root,COG0392@2|Bacteria,2I8EG@201174|Actinobacteria	201174|Actinobacteria	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	-	-	-	-	-	-	-	-	-	LPG_synthase_TM
REGS3_k127_6343775_0	118163.Ple7327_2484	2.441e-94	338.0	COG2898@1|root,COG2898@2|Bacteria,1G1E7@1117|Cyanobacteria,3VMFC@52604|Pleurocapsales	1117|Cyanobacteria	S	Transmembrane region of lysyl-tRNA synthetase	-	-	2.3.2.3	ko:K07027,ko:K14205	ko01503,ko02020,ko05150,map01503,map02020,map05150	M00726	-	-	ko00000,ko00001,ko00002,ko01000,ko01504,ko02000	2.A.1.3.37,4.D.2	-	-	DUF2156,tRNA-synt_2_TM
REGS3_k127_6343775_1	1313172.YM304_30800	1.315e-76	273.0	COG1376@1|root,COG3409@1|root,COG1376@2|Bacteria,COG3409@2|Bacteria	2|Bacteria	M	Peptidoglycan-binding domain 1 protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF2778,PG_binding_1,YkuD
REGS3_k127_6347565_2	1370121.AUWS01000062_gene3875	5.04e-61	221.0	COG2114@1|root,COG3903@1|root,COG2114@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria,233DM@1762|Mycobacteriaceae	201174|Actinobacteria	K	involved in signal transduction (via phosphorylation) involved in transcriptional regulatory mechanism and in the regulation of secondary metabolites catalytic activity ATP a protein ADP a phosphoprotein	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22,GerE,Guanylate_cyc,NB-ARC
REGS3_k127_6347565_3	35754.JNYJ01000011_gene642	1.16e-17	92.0	COG1595@1|root,COG1595@2|Bacteria,2IRC1@201174|Actinobacteria,4DJ3E@85008|Micromonosporales	201174|Actinobacteria	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
REGS3_k127_6347565_0	571166.KI421509_gene945	1.368e-215	677.0	COG1960@1|root,COG1960@2|Bacteria,1MU2V@1224|Proteobacteria,2TSK3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	acyl-CoA dehydrogenase	MA20_16395	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
REGS3_k127_6347565_1	1394178.AWOO02000025_gene5068	1.618e-87	298.0	COG2141@1|root,COG2141@2|Bacteria,2GMMJ@201174|Actinobacteria,4EGKE@85012|Streptosporangiales	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
REGS3_k127_6347565_4	1089544.KB912942_gene6549	5.563e-06	50.0	COG2308@1|root,COG2308@2|Bacteria,2GN0J@201174|Actinobacteria,4E0HH@85010|Pseudonocardiales	201174|Actinobacteria	S	Circularly permuted ATP-grasp type 2	gcs2	-	-	-	-	-	-	-	-	-	-	-	Alpha-E,CP_ATPgrasp_1,CP_ATPgrasp_2
REGS3_k127_6357449_7	756067.MicvaDRAFT_3420	0.0001462	53.0	COG0823@1|root,COG2931@1|root,COG0823@2|Bacteria,COG2931@2|Bacteria,1G554@1117|Cyanobacteria,1HF7I@1150|Oscillatoriales	1117|Cyanobacteria	QU	PFAM Haemolysin-type calcium-binding repeat	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind,PD40
REGS3_k127_6357449_1	1120934.KB894405_gene5281	3.12e-75	270.0	COG1470@1|root,COG1470@2|Bacteria,2H4ZH@201174|Actinobacteria,4E24A@85010|Pseudonocardiales	201174|Actinobacteria	S	cell adhesion involved in biofilm formation	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1
REGS3_k127_6357449_2	479431.Namu_1891	8.711e-63	224.0	COG2197@1|root,COG2197@2|Bacteria,2GNUE@201174|Actinobacteria,4EVX9@85013|Frankiales	201174|Actinobacteria	K	luxR family	-	-	-	-	-	-	-	-	-	-	-	-	GerE
REGS3_k127_6357449_5	67332.FM21_28215	2.197e-24	113.0	28RC2@1|root,2ZDRH@2|Bacteria,2GNI9@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF4255)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4255
REGS3_k127_6357449_0	345341.KUTG_07888	6.677e-242	759.0	COG3497@1|root,COG3497@2|Bacteria,2GMJA@201174|Actinobacteria,4E0BB@85010|Pseudonocardiales	201174|Actinobacteria	S	Phage tail sheath C-terminal domain	-	-	-	ko:K06907	-	-	-	-	ko00000	-	-	-	Phage_sheath_1,Phage_sheath_1C
REGS3_k127_6357449_4	1120934.KB894405_gene5266	2.68e-52	188.0	2ACY3@1|root,312JQ@2|Bacteria	2|Bacteria	S	T4-like virus tail tube protein gp19	-	-	-	-	-	-	-	-	-	-	-	-	Phage_T4_gp19
REGS3_k127_6357449_3	981369.JQMJ01000001_gene6784	5.321e-55	196.0	arCOG11412@1|root,31S84@2|Bacteria,2IHRW@201174|Actinobacteria,2NIPM@228398|Streptacidiphilus	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_6357449_6	479431.Namu_1902	1.001e-11	66.0	arCOG11411@1|root,33A8Q@2|Bacteria,2GRHE@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_6380351_3	1313172.YM304_10050	3.296e-229	712.0	COG1035@1|root,COG1146@1|root,COG1035@2|Bacteria,COG1146@2|Bacteria,2GRHK@201174|Actinobacteria	201174|Actinobacteria	C	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term	-	-	1.12.98.1	ko:K00441	ko00680,ko01100,ko01120,map00680,map01100,map01120	-	R03025	RC02628	ko00000,ko00001,ko01000	-	-	-	Fer4_9,FrhB_FdhB_C,FrhB_FdhB_N
REGS3_k127_6380351_0	28042.GU90_16820	7.693e-249	793.0	COG1529@1|root,COG1529@2|Bacteria,2GIVI@201174|Actinobacteria,4E2BB@85010|Pseudonocardiales	201174|Actinobacteria	C	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL	cutL	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
REGS3_k127_6380351_2	1313172.YM304_23260	1.686e-230	727.0	COG0465@1|root,COG0465@2|Bacteria,2I9X7@201174|Actinobacteria,4CNSR@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Peptidase family M41	-	-	-	-	-	-	-	-	-	-	-	-	AAA,Peptidase_M41
REGS3_k127_6380351_1	1313172.YM304_10130	5.027e-234	728.0	COG1960@1|root,COG1960@2|Bacteria,2GM1Q@201174|Actinobacteria	2|Bacteria	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
REGS3_k127_6380351_10	1123320.KB889685_gene2203	9.272e-184	587.0	COG0122@1|root,COG2169@1|root,COG0122@2|Bacteria,COG2169@2|Bacteria,2GITG@201174|Actinobacteria	201174|Actinobacteria	K	helix-turn-helix- domain containing protein, AraC type	ada	-	3.2.2.21	ko:K13529	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03000,ko03400	-	-	-	Ada_Zn_binding,AlkA_N,HTH_18,HhH-GPD
REGS3_k127_6380351_18	1313172.YM304_10170	1.698e-57	206.0	COG0350@1|root,COG0350@2|Bacteria,2IHXW@201174|Actinobacteria,4CN9C@84992|Acidimicrobiia	84992|Acidimicrobiia	L	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated	ogt	-	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1,Methyltransf_1N
REGS3_k127_6380351_13	1123073.KB899241_gene2886	7.368e-93	314.0	2DNAS@1|root,32WH6@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Phi_1
REGS3_k127_6380351_20	479431.Namu_0354	7.699e-39	155.0	COG1277@1|root,COG1277@2|Bacteria,2ID14@201174|Actinobacteria,4EUG6@85013|Frankiales	201174|Actinobacteria	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
REGS3_k127_6380351_12	1121272.KB903254_gene6632	5.038e-100	335.0	COG4152@1|root,COG4152@2|Bacteria,2I2U6@201174|Actinobacteria,4DMD2@85008|Micromonosporales	201174|Actinobacteria	S	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	AAA_21,ABC_tran,DUF4162
REGS3_k127_6380351_4	1313172.YM304_10300	3.348e-221	699.0	COG0018@1|root,COG0018@2|Bacteria,2GKQ3@201174|Actinobacteria,4CNAI@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Arginyl tRNA synthetase N terminal dom	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
REGS3_k127_6380351_6	1313172.YM304_10310	6.74e-211	666.0	COG0019@1|root,COG0019@2|Bacteria,2GKAI@201174|Actinobacteria,4CMVX@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
REGS3_k127_6380351_14	477641.MODMU_1661	2.388e-85	291.0	COG0672@1|root,COG0672@2|Bacteria,2GJ22@201174|Actinobacteria,4ESSF@85013|Frankiales	201174|Actinobacteria	P	PFAM Iron permease FTR1	efeU	-	-	ko:K07243	-	-	-	-	ko00000,ko02000	2.A.108.1,2.A.108.2	-	-	FTR1
REGS3_k127_6380351_9	1313172.YM304_10340	2.386e-184	585.0	COG0460@1|root,COG2844@1|root,COG0460@2|Bacteria,COG2844@2|Bacteria,2GIX9@201174|Actinobacteria,4CMW6@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Homoserine dehydrogenase	hom	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,Homoserine_dh,NAD_binding_3
REGS3_k127_6380351_8	1313172.YM304_10350	5.171e-198	628.0	COG0498@1|root,COG0498@2|Bacteria,2GIRY@201174|Actinobacteria	201174|Actinobacteria	E	Threonine synthase	thrC	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP,Thr_synth_N
REGS3_k127_6380351_5	1313172.YM304_10360	3.461e-217	692.0	COG1158@1|root,COG1158@2|Bacteria,2GIWY@201174|Actinobacteria,4CMS7@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_RNA_bind
REGS3_k127_6380351_21	1313172.YM304_10420	1.436e-30	124.0	COG0254@1|root,COG0254@2|Bacteria,2IQ4I@201174|Actinobacteria,4CP0K@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Binds the 23S rRNA	rpmE	-	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
REGS3_k127_6380351_17	1120973.AQXL01000125_gene3126	6.494e-73	262.0	COG5267@1|root,COG5267@2|Bacteria,1VGX0@1239|Firmicutes,4HUYI@91061|Bacilli	91061|Bacilli	S	Protein of unknown function (DUF1800)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1800
REGS3_k127_6380351_7	1313172.YM304_10440	3.295e-206	670.0	COG4102@1|root,COG4102@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
REGS3_k127_6380351_16	1313172.YM304_10460	2.481e-77	270.0	28TNP@1|root,2ZFW6@2|Bacteria,2HAX0@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_6380351_11	1313172.YM304_10470	8.095e-135	437.0	COG0216@1|root,COG0216@2|Bacteria,2GJWG@201174|Actinobacteria,4CMPQ@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
REGS3_k127_6380351_15	1313172.YM304_10480	2.607e-81	284.0	COG2890@1|root,COG2890@2|Bacteria,2GMH1@201174|Actinobacteria,4CN5W@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Methyltransferase small domain	-	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS
REGS3_k127_6380351_22	1313172.YM304_11290	1.436e-20	92.0	COG1403@1|root,COG1403@2|Bacteria,2ICGQ@201174|Actinobacteria	201174|Actinobacteria	V	Domain of unknown function (DUF222)	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
REGS3_k127_642355_5	479433.Caci_7536	1.707e-15	79.0	COG0438@1|root,COG0438@2|Bacteria,2GNPG@201174|Actinobacteria	201174|Actinobacteria	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
REGS3_k127_642355_9	469371.Tbis_2744	4.961e-05	52.0	COG2172@1|root,COG2172@2|Bacteria	2|Bacteria	T	sigma factor antagonist activity	-	-	2.7.11.1	ko:K04757,ko:K17752	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	HATPase_c_2
REGS3_k127_642355_7	1246445.ANAY01000002_gene3363	1.175e-06	55.0	COG1366@1|root,COG1366@2|Bacteria	2|Bacteria	T	antisigma factor binding	-	-	-	ko:K03090,ko:K04749,ko:K06378	-	-	-	-	ko00000,ko03021	-	-	-	STAS,STAS_2
REGS3_k127_642355_8	1304880.JAGB01000001_gene592	2.397e-06	56.0	COG2172@1|root,COG2172@2|Bacteria	2|Bacteria	T	sigma factor antagonist activity	rsbW	-	2.7.11.1	ko:K04757	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	HATPase_c,HATPase_c_2
REGS3_k127_642355_2	298653.Franean1_0974	3.66e-57	208.0	COG1191@1|root,COG1191@2|Bacteria,2GKSY@201174|Actinobacteria,4ES7X@85013|Frankiales	201174|Actinobacteria	K	RNA polymerase	sigF	GO:0000988,GO:0000990,GO:0003674,GO:0005488,GO:0005515,GO:0006355,GO:0006629,GO:0006950,GO:0006979,GO:0006995,GO:0007154,GO:0008150,GO:0008152,GO:0009266,GO:0009267,GO:0009409,GO:0009605,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0009991,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016987,GO:0019219,GO:0019222,GO:0019899,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034059,GO:0036293,GO:0042221,GO:0042594,GO:0043175,GO:0043254,GO:0043562,GO:0044087,GO:0044238,GO:0045893,GO:0045935,GO:0046677,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0070063,GO:0070417,GO:0070482,GO:0071496,GO:0071704,GO:0080090,GO:0140110,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2000142,GO:2001141	-	ko:K03090	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r3,Sigma70_r4
REGS3_k127_642355_0	469383.Cwoe_3142	4.351e-68	244.0	COG4932@1|root,COG4932@2|Bacteria,2GJ4T@201174|Actinobacteria,4CSJH@84995|Rubrobacteria	84995|Rubrobacteria	M	Protein of unknown function (DUF3494)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3494
REGS3_k127_642355_6	253839.SSNG_03359	1.465e-10	68.0	2EK8X@1|root,33DZ6@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_642355_1	35754.JNYJ01000052_gene6634	4.142e-59	219.0	COG0628@1|root,COG0628@2|Bacteria,2GN4Y@201174|Actinobacteria,4D8Z9@85008|Micromonosporales	201174|Actinobacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
REGS3_k127_642355_3	710686.Mycsm_01607	5.049e-47	181.0	COG1597@1|root,COG1597@2|Bacteria,2GJ3K@201174|Actinobacteria	201174|Actinobacteria	I	Diacylglycerol kinase	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	DAGK_cat,PAP2
REGS3_k127_642355_4	1243664.CAVL020000008_gene4322	4.468e-16	88.0	COG0671@1|root,COG0671@2|Bacteria,1VF2U@1239|Firmicutes,4HNXR@91061|Bacilli,1ZIEP@1386|Bacillus	91061|Bacilli	I	COG0671 Membrane-associated phospholipid phosphatase	pap2c	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
REGS3_k127_6441460_4	1267535.KB906767_gene3779	1.642e-29	130.0	2CMWR@1|root,32SFR@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_6441460_3	1054860.KB913030_gene5536	8.326e-82	275.0	COG1335@1|root,COG1335@2|Bacteria,2IG6Q@201174|Actinobacteria	201174|Actinobacteria	Q	isochorismatase	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
REGS3_k127_6441460_1	1033730.CAHG01000012_gene2002	3.031e-164	526.0	COG0001@1|root,COG0001@2|Bacteria,2GJSH@201174|Actinobacteria,4DNRS@85009|Propionibacteriales	201174|Actinobacteria	H	Glutamate-1-semialdehyde aminotransferase	-	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
REGS3_k127_6441460_0	1033730.CAHG01000012_gene2001	4.058e-208	659.0	COG1012@1|root,COG1012@2|Bacteria,2GMNB@201174|Actinobacteria	201174|Actinobacteria	C	Aldehyde dehydrogenase	-	-	1.2.1.3	ko:K00128,ko:K22187	ko00010,ko00040,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00040,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146,R11768	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
REGS3_k127_6441460_2	1033730.CAHG01000012_gene2000	1.562e-101	338.0	COG0665@1|root,COG0665@2|Bacteria	2|Bacteria	E	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity	-	-	1.5.3.1	ko:K00303	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO
REGS3_k127_64530_4	1313172.YM304_09210	4.443e-78	271.0	COG0204@1|root,COG0204@2|Bacteria,2H2S8@201174|Actinobacteria	201174|Actinobacteria	I	Phosphate acyltransferases	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
REGS3_k127_64530_9	765420.OSCT_3060	2.328e-40	160.0	COG0739@1|root,COG0739@2|Bacteria,2GADD@200795|Chloroflexi,375JT@32061|Chloroflexia	32061|Chloroflexia	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
REGS3_k127_64530_3	298654.FraEuI1c_3249	7.61e-103	340.0	COG0411@1|root,COG0411@2|Bacteria,2IJ5Y@201174|Actinobacteria,4EV5P@85013|Frankiales	201174|Actinobacteria	E	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
REGS3_k127_64530_5	298654.FraEuI1c_3250	1.308e-77	269.0	COG0410@1|root,COG0410@2|Bacteria,2GKSQ@201174|Actinobacteria,4EV8S@85013|Frankiales	201174|Actinobacteria	E	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
REGS3_k127_64530_6	234621.RER_44850	5.142e-75	262.0	COG0559@1|root,COG0559@2|Bacteria,2HDZ9@201174|Actinobacteria,4FXXC@85025|Nocardiaceae	201174|Actinobacteria	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
REGS3_k127_64530_7	234621.RER_44840	4.804e-63	231.0	COG4177@1|root,COG4177@2|Bacteria,2GMGD@201174|Actinobacteria,4FXEZ@85025|Nocardiaceae	201174|Actinobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
REGS3_k127_64530_12	1229780.BN381_130109	2.451e-32	143.0	COG0683@1|root,COG0683@2|Bacteria,2HN41@201174|Actinobacteria,3UXIC@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	E	Periplasmic binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
REGS3_k127_64530_10	1122247.C731_2678	1.483e-37	156.0	COG2114@1|root,COG2114@2|Bacteria,2GN02@201174|Actinobacteria,234WK@1762|Mycobacteriaceae	201174|Actinobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	GO:0003674,GO:0003824,GO:0004016,GO:0005488,GO:0005504,GO:0006139,GO:0006163,GO:0006164,GO:0006171,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008289,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009187,GO:0009190,GO:0009259,GO:0009260,GO:0009975,GO:0009987,GO:0016829,GO:0016849,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0031406,GO:0033293,GO:0034641,GO:0034654,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046058,GO:0046390,GO:0046483,GO:0052652,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Ad_Cy_reg,Guanylate_cyc
REGS3_k127_64530_14	1122603.ATVI01000012_gene1096	3.252e-14	83.0	COG0454@1|root,COG0456@2|Bacteria,1QZJR@1224|Proteobacteria,1S8SA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
REGS3_k127_64530_0	1071679.BG57_31120	5.526e-184	581.0	COG4948@1|root,COG4948@2|Bacteria,1MU8R@1224|Proteobacteria,2VH1R@28216|Betaproteobacteria,1K89F@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	menC	-	4.2.1.113,4.2.1.171,5.1.1.20	ko:K02549,ko:K19802,ko:K21624	ko00130,ko00330,ko01100,ko01110,map00130,map00330,map01100,map01110	M00116	R04031,R10938,R11625	RC01053,RC03309	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
REGS3_k127_64530_2	765698.Mesci_0555	1.273e-134	441.0	COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,2TUMJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	aminotransferase class V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
REGS3_k127_64530_13	313589.JNB_14253	9.092e-28	123.0	2C72U@1|root,32W8F@2|Bacteria,2GTSA@201174|Actinobacteria,4FHME@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_64530_11	1313172.YM304_02510	5.846e-33	140.0	2DBB1@1|root,2Z854@2|Bacteria,2GNBN@201174|Actinobacteria	201174|Actinobacteria	S	Domain of Unknown Function (DUF1206)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1206
REGS3_k127_64530_1	251221.35214398	2.737e-142	470.0	COG3540@1|root,COG3540@2|Bacteria	2|Bacteria	P	PhoD-like phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	PhoD
REGS3_k127_64530_8	1283283.ATXA01000014_gene3609	1.102e-40	162.0	COG0671@1|root,COG0671@2|Bacteria,2IAUJ@201174|Actinobacteria,4EW1N@85013|Frankiales	201174|Actinobacteria	I	PAP2 superfamily	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	DUF2189,PAP2
REGS3_k127_6470349_10	1313172.YM304_04210	1.583e-26	119.0	COG1403@1|root,COG1403@2|Bacteria	2|Bacteria	V	endonuclease activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
REGS3_k127_6470349_2	365528.KB891241_gene6323	1.2e-106	355.0	COG2267@1|root,COG2267@2|Bacteria,2I0NW@201174|Actinobacteria,4EX2Y@85013|Frankiales	201174|Actinobacteria	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4
REGS3_k127_6470349_3	1282876.BAOK01000001_gene2087	7.016e-105	351.0	28M2T@1|root,2ZAH6@2|Bacteria,1R6GW@1224|Proteobacteria,2U25T@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_6470349_5	1313172.YM304_15460	3.668e-100	334.0	COG4221@1|root,COG4221@2|Bacteria,2I2DY@201174|Actinobacteria	201174|Actinobacteria	S	Dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
REGS3_k127_6470349_1	1313172.YM304_15480	1.295e-168	541.0	COG1020@1|root,COG1020@2|Bacteria,2GKU0@201174|Actinobacteria	201174|Actinobacteria	Q	diacylglycerol O-acyltransferase	-	GO:0000302,GO:0001666,GO:0003674,GO:0003824,GO:0004144,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006629,GO:0006638,GO:0006639,GO:0006641,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008374,GO:0008610,GO:0009058,GO:0009628,GO:0009987,GO:0010035,GO:0016020,GO:0016411,GO:0016740,GO:0016746,GO:0016747,GO:0019432,GO:0030312,GO:0036293,GO:0040007,GO:0042221,GO:0042493,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044403,GO:0044419,GO:0044464,GO:0045017,GO:0046460,GO:0046463,GO:0046486,GO:0047196,GO:0050896,GO:0051704,GO:0070482,GO:0071704,GO:0071731,GO:0071944,GO:0097366,GO:1901576,GO:1901698,GO:1901700	2.3.1.20	ko:K00635	ko00561,ko01100,map00561,map01100	M00089	R02251	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1298,WES_acyltransf
REGS3_k127_6470349_8	1313172.YM304_15490	2.701e-52	191.0	COG0671@1|root,COG0671@2|Bacteria,2HGAE@201174|Actinobacteria,4CN9F@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Acid phosphatase homologues	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
REGS3_k127_6470349_4	1313172.YM304_15500	2.538e-100	334.0	COG2887@1|root,COG2887@2|Bacteria,2GJC5@201174|Actinobacteria,4CN3P@84992|Acidimicrobiia	84992|Acidimicrobiia	L	PD-(D/E)XK nuclease superfamily	-	-	-	ko:K07465	-	-	-	-	ko00000	-	-	-	PDDEXK_1
REGS3_k127_6470349_6	446468.Ndas_1183	7.007e-83	289.0	COG1960@1|root,COG1960@2|Bacteria,2GMKM@201174|Actinobacteria,4EKAD@85012|Streptosporangiales	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.14.13.235	ko:K22027	-	-	-	-	ko00000,ko01000	-	-	-	Acyl-CoA_dh_2,Acyl-CoA_dh_N
REGS3_k127_6470349_7	1313172.YM304_15510	1.703e-59	215.0	COG2267@1|root,COG2267@2|Bacteria,2HGVY@201174|Actinobacteria,4CNX3@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
REGS3_k127_6470349_0	1313172.YM304_15530	6.101e-185	584.0	COG1960@1|root,COG1960@2|Bacteria	2|Bacteria	I	acyl-CoA dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
REGS3_k127_6534987_6	1385519.N801_06610	1.27e-82	286.0	COG0438@1|root,COG0438@2|Bacteria,2GNPG@201174|Actinobacteria,4FJ4K@85021|Intrasporangiaceae	201174|Actinobacteria	M	Glycosyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
REGS3_k127_6534987_14	326424.FRAAL3904	4.326e-40	172.0	COG2203@1|root,COG2208@1|root,COG3920@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,COG3920@2|Bacteria,2GK8P@201174|Actinobacteria,4EXCE@85013|Frankiales	201174|Actinobacteria	T	Sigma factor PP2C-like phosphatases	-	-	2.7.11.1	ko:K04757	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	GAF,GAF_2,GAF_3,HATPase_c_2,PAS_9,SpoIIE
REGS3_k127_6534987_13	469383.Cwoe_3147	7.856e-43	166.0	COG2203@1|root,COG2203@2|Bacteria,2IQAM@201174|Actinobacteria	201174|Actinobacteria	T	ANTAR	-	-	-	-	-	-	-	-	-	-	-	-	ANTAR,GAF_2
REGS3_k127_6534987_8	227882.SAV_4628	2.442e-68	240.0	COG2203@1|root,COG2203@2|Bacteria,2GQ2V@201174|Actinobacteria	201174|Actinobacteria	T	ANTAR domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ANTAR,GAF_2
REGS3_k127_6534987_23	1380390.JIAT01000014_gene6167	2.136e-05	52.0	COG1366@1|root,COG1366@2|Bacteria,2HPDG@201174|Actinobacteria,4CQRG@84995|Rubrobacteria	84995|Rubrobacteria	T	STAS domain	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS
REGS3_k127_6534987_16	1123258.AQXZ01000017_gene3806	9.216e-40	153.0	COG4420@1|root,COG4420@2|Bacteria,2GQ5D@201174|Actinobacteria,4G70Y@85025|Nocardiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF1003)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1003
REGS3_k127_6534987_0	1341646.CBMO010000042_gene4873	1.153e-155	522.0	COG2152@1|root,COG2152@2|Bacteria,2HNS8@201174|Actinobacteria,233RX@1762|Mycobacteriaceae	201174|Actinobacteria	G	beta-1,4-mannooligosaccharide phosphorylase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_130
REGS3_k127_6534987_4	1440774.Y900_017535	4.826e-94	339.0	COG0438@1|root,COG0438@2|Bacteria,2I97T@201174|Actinobacteria,235R1@1762|Mycobacteriaceae	201174|Actinobacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_6534987_18	134676.ACPL_4921	4.534e-27	117.0	COG5478@1|root,COG5478@2|Bacteria,2GS41@201174|Actinobacteria,4DKFW@85008|Micromonosporales	201174|Actinobacteria	S	Low affinity iron permease	-	-	-	-	-	-	-	-	-	-	-	-	Iron_permease
REGS3_k127_6534987_15	1313172.YM304_02520	5.837e-40	162.0	COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria	2|Bacteria	M	LysM domain	-	-	-	ko:K12204	-	-	-	-	ko00000,ko02044	3.A.7.10.1,3.A.7.9.1	-	-	Amidase_2,FecR,LysM,PG_binding_1,SLT
REGS3_k127_6534987_21	1237500.ANBA01000009_gene1102	1.601e-12	78.0	COG2132@1|root,COG2132@2|Bacteria,2I8HQ@201174|Actinobacteria,4EGN9@85012|Streptosporangiales	201174|Actinobacteria	Q	Multicopper oxidase	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_6534987_7	391613.RTM1035_11385	3.172e-79	269.0	COG3665@1|root,COG3665@2|Bacteria,1N9DM@1224|Proteobacteria,2TU1Z@28211|Alphaproteobacteria,46PIN@74030|Roseovarius	28211|Alphaproteobacteria	S	Domain of unknown function (DUF1989)	-	-	-	ko:K09967	-	-	-	-	ko00000	-	-	-	DUF1989
REGS3_k127_6534987_3	710111.FraQA3DRAFT_1888	4.963e-103	342.0	COG0030@1|root,COG0030@2|Bacteria,2GIZ8@201174|Actinobacteria,4EW0R@85013|Frankiales	201174|Actinobacteria	J	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
REGS3_k127_6534987_12	1229780.BN381_170012	7.17e-46	173.0	COG2846@1|root,COG2846@2|Bacteria,2IKUD@201174|Actinobacteria	201174|Actinobacteria	D	Di-iron-containing protein involved in the repair of iron-sulfur clusters	-	-	-	ko:K07322	-	-	-	-	ko00000	-	-	-	Hemerythrin,ScdA_N
REGS3_k127_6534987_2	1313172.YM304_27830	2.046e-124	407.0	COG2141@1|root,COG2141@2|Bacteria,2GJI7@201174|Actinobacteria	201174|Actinobacteria	C	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
REGS3_k127_6534987_10	1313172.YM304_16320	1.09e-58	226.0	COG2755@1|root,COG2755@2|Bacteria	2|Bacteria	E	lipolytic protein G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	F5_F8_type_C,Laminin_G_3,Lipase_GDSL_2,PT-HINT,RHS_repeat,Ricin_B_lectin
REGS3_k127_6534987_11	1313172.YM304_29060	1.296e-50	191.0	COG3786@1|root,COG3786@2|Bacteria	2|Bacteria	-	-	ddpX	-	3.4.13.22	ko:K08641	ko01502,ko02020,map01502,map02020	M00651	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504	-	-	-	YkuD
REGS3_k127_6534987_5	1229780.BN381_100200	2.286e-92	310.0	COG3752@1|root,COG3752@2|Bacteria,2GNX1@201174|Actinobacteria,3UXBY@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	Isoprenylcysteine carboxyl methyltransferase (ICMT) family	-	-	-	-	-	-	-	-	-	-	-	-	DUF1295
REGS3_k127_6534987_9	1229780.BN381_60078	1.384e-61	225.0	COG0204@1|root,COG0204@2|Bacteria,2I8I4@201174|Actinobacteria	201174|Actinobacteria	I	PFAM Phospholipid glycerol acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase
REGS3_k127_6534987_1	1313172.YM304_02500	2.621e-125	408.0	COG1028@1|root,COG1028@2|Bacteria,2I32I@201174|Actinobacteria	201174|Actinobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
REGS3_k127_6534987_22	1306174.JODP01000027_gene108	2.898e-09	66.0	2EPZ4@1|root,33HJQ@2|Bacteria,2GYV7@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_6548219_4	1209072.ALBT01000033_gene1692	7.085e-05	55.0	COG0265@1|root,COG5184@1|root,COG0265@2|Bacteria,COG5184@2|Bacteria,1PG4J@1224|Proteobacteria,1RWXR@1236|Gammaproteobacteria,1FIEH@10|Cellvibrio	1236|Gammaproteobacteria	DZ	Regulator of chromosome condensation (RCC1) repeat	-	-	-	-	-	-	-	-	-	-	-	-	RCC1
REGS3_k127_6548219_1	1313172.YM304_22320	1.074e-90	319.0	COG0823@1|root,COG1520@1|root,COG3170@1|root,COG0823@2|Bacteria,COG1520@2|Bacteria,COG3170@2|Bacteria	2|Bacteria	NU	translation initiation factor activity	yidR	GO:0005975,GO:0005996,GO:0006063,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0019586,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046365,GO:0046395,GO:0046397,GO:0071704,GO:0072329,GO:1901575	-	ko:K02040,ko:K03074,ko:K20541	ko02010,ko02020,ko03060,ko03070,ko05152,map02010,map02020,map03060,map03070,map05152	M00222,M00335	-	-	ko00000,ko00001,ko00002,ko02000,ko02044	2.A.6.4,3.A.1.7,3.A.5.2,3.A.5.7,4.D.3.1.6	-	-	DUF3748,PD40
REGS3_k127_6548219_0	1229780.BN381_250079	1.186e-316	983.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,2GK8E@201174|Actinobacteria,3UWJK@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	NADH:flavin oxidoreductase / NADH oxidase family	-	-	1.3.1.34	ko:K00219	-	-	-	-	ko00000,ko01000	-	-	-	FAD_oxidored,Oxidored_FMN,Pyr_redox_2
REGS3_k127_6548219_2	1184609.KILIM_073_00190	2.477e-80	280.0	COG0697@1|root,COG0697@2|Bacteria,2IPY1@201174|Actinobacteria	201174|Actinobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
REGS3_k127_6548219_3	1410620.SHLA_23c000470	1.734e-19	89.0	COG0010@1|root,COG0010@2|Bacteria,1MVFH@1224|Proteobacteria,2TT0P@28211|Alphaproteobacteria,4B7IA@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Arginase family	-	-	3.5.3.11	ko:K01480	ko00330,ko01100,map00330,map01100	M00133	R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
REGS3_k127_6586476_1	1287116.X734_27895	1.194e-51	193.0	COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,2TS4Y@28211|Alphaproteobacteria	2|Bacteria	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG2	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
REGS3_k127_6586476_0	1122609.AUGT01000003_gene2451	1.317e-53	204.0	COG1819@1|root,COG1819@2|Bacteria,2GJN7@201174|Actinobacteria,4DR7K@85009|Propionibacteriales	201174|Actinobacteria	CG	UDP-glucoronosyl and UDP-glucosyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tran_28_C,UDPGT
REGS3_k127_6586476_2	935839.JAGJ01000025_gene2519	3.83e-36	144.0	COG2154@1|root,COG2154@2|Bacteria,2IHZE@201174|Actinobacteria,4F4PK@85017|Promicromonosporaceae	201174|Actinobacteria	H	Pterin 4 alpha carbinolamine dehydratase	-	-	4.2.1.96	ko:K01724	ko00790,map00790	-	R04734	RC01208	ko00000,ko00001,ko01000,ko04147	-	-	-	Pterin_4a
REGS3_k127_6608625_5	937777.Deipe_2583	2.925e-25	113.0	COG3224@1|root,COG3224@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K09932	-	-	-	-	ko00000	-	-	-	ABM
REGS3_k127_6608625_3	1313172.YM304_26740	1.886e-36	143.0	COG0799@1|root,COG0799@2|Bacteria,2IKZ3@201174|Actinobacteria,4CN96@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation	rsfS	-	-	ko:K09710	-	-	-	-	ko00000,ko03009	-	-	-	RsfS
REGS3_k127_6608625_2	1313172.YM304_26760	1.272e-75	260.0	COG1057@1|root,COG1057@2|Bacteria,2GMFZ@201174|Actinobacteria,4CN49@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	-	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
REGS3_k127_6608625_1	1313172.YM304_26770	1.17e-145	466.0	COG0568@1|root,COG0568@2|Bacteria,2GK3Z@201174|Actinobacteria,4CMST@84992|Acidimicrobiia	201174|Actinobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Helicase_C,ResIII,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
REGS3_k127_6608625_0	1313172.YM304_26780	1.184e-160	514.0	COG3200@1|root,COG3200@2|Bacteria,2GJBX@201174|Actinobacteria,4CMTE@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Class-II DAHP synthetase family	-	-	2.5.1.54	ko:K01626	ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_2
REGS3_k127_6673261_4	663278.Ethha_1989	7.358e-31	140.0	28QPF@1|root,2ZD50@2|Bacteria,1V2FS@1239|Firmicutes,24IPX@186801|Clostridia,3WMAD@541000|Ruminococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_6673261_1	485913.Krac_9368	1.281e-121	410.0	COG1215@1|root,COG1215@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	2.4.1.12	ko:K00694	ko00500,ko01100,ko02026,map00500,map01100,map02026	-	R02889	RC00005	ko00000,ko00001,ko01000,ko01003,ko02000	4.D.3.1.2,4.D.3.1.5,4.D.3.1.6	GT2	-	Glyco_tranf_2_3
REGS3_k127_6673261_3	926569.ANT_29930	1.214e-90	308.0	COG2116@1|root,COG2116@2|Bacteria,2G967@200795|Chloroflexi	200795|Chloroflexi	P	Formate/nitrite transporter	-	-	-	ko:K06212	-	-	-	-	ko00000,ko02000	1.A.16.1.1,1.A.16.1.3	-	-	Form_Nir_trans
REGS3_k127_6673261_0	247634.GPB2148_1166	2.884e-141	457.0	COG0657@1|root,COG0657@2|Bacteria,1NRN8@1224|Proteobacteria,1SK0Q@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Carboxylesterase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3
REGS3_k127_6673261_5	525909.Afer_0906	2.2e-21	96.0	COG1141@1|root,COG1141@2|Bacteria,2IKKX@201174|Actinobacteria,4CN8X@84992|Acidimicrobiia	84992|Acidimicrobiia	C	4Fe-4S single cluster domain of Ferredoxin I	-	-	-	ko:K05337	-	-	-	-	ko00000	-	-	-	Fer4_15
REGS3_k127_6673261_6	1313172.YM304_35860	1.859e-09	70.0	COG0443@1|root,COG0443@2|Bacteria,2GJTY@201174|Actinobacteria,4CMVI@84992|Acidimicrobiia	201174|Actinobacteria	O	Heat shock 70 kDa protein	-	-	-	-	-	-	-	-	-	-	-	-	HSP70,RNase_Zc3h12a
REGS3_k127_6673261_2	1313172.YM304_35860	9.679e-114	380.0	COG0443@1|root,COG0443@2|Bacteria,2GJTY@201174|Actinobacteria,4CMVI@84992|Acidimicrobiia	201174|Actinobacteria	O	Heat shock 70 kDa protein	-	-	-	-	-	-	-	-	-	-	-	-	HSP70,RNase_Zc3h12a
REGS3_k127_6726413_5	711393.AYRX01000062_gene2129	3.402e-64	226.0	COG1804@1|root,COG1804@2|Bacteria,2GIU7@201174|Actinobacteria	201174|Actinobacteria	C	L-carnitine dehydratase bile acid-inducible protein F	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
REGS3_k127_6726413_6	1313172.YM304_33790	2.713e-54	201.0	COG0586@1|root,COG0586@2|Bacteria,2GKKC@201174|Actinobacteria,4CNDD@84992|Acidimicrobiia	84992|Acidimicrobiia	S	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
REGS3_k127_6726413_3	882083.SacmaDRAFT_1199	1.032e-75	265.0	COG2025@1|root,COG2025@2|Bacteria,2IIKX@201174|Actinobacteria	201174|Actinobacteria	C	Electron transfer flavoprotein alpha subunit	-	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
REGS3_k127_6726413_0	1157638.KB892174_gene326	3.704e-175	559.0	COG0644@1|root,COG0644@2|Bacteria	2|Bacteria	C	geranylgeranyl reductase activity	-	-	-	ko:K00313	-	-	-	-	ko00000,ko01000	-	-	-	DAO,FAD_binding_3,FAD_oxidored,Pyr_redox_2
REGS3_k127_6726413_8	882083.SacmaDRAFT_1197	1.027e-35	143.0	COG2440@1|root,COG2440@2|Bacteria,2IQVY@201174|Actinobacteria	201174|Actinobacteria	C	electron transfer flavoprotein-ubiquinone oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	ETF_QO,Fer4_9
REGS3_k127_6726413_7	656024.FsymDg_2650	2.971e-41	166.0	COG2086@1|root,COG2086@2|Bacteria,2GSWB@201174|Actinobacteria	201174|Actinobacteria	C	Electron transfer flavoprotein	-	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
REGS3_k127_6726413_1	35754.JNYJ01000046_gene3102	6.375e-154	503.0	COG1520@1|root,COG1520@2|Bacteria,2I9S4@201174|Actinobacteria,4D97G@85008|Micromonosporales	201174|Actinobacteria	S	beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,PQQ_3
REGS3_k127_6726413_4	1448389.BAVQ01000025_gene1273	3.15e-64	227.0	COG1402@1|root,COG1402@2|Bacteria,2HCRK@201174|Actinobacteria	201174|Actinobacteria	S	Creatininase	mftE	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
REGS3_k127_6726413_2	1157638.KB892174_gene322	1.584e-115	391.0	COG1215@1|root,COG1215@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glycos_transf_2
REGS3_k127_6726413_9	446470.Snas_5222	3.416e-12	68.0	2DMC7@1|root,32J0V@2|Bacteria,2I81N@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF4395)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4395
REGS3_k127_6738236_4	1380347.JNII01000005_gene3148	1.32e-31	128.0	COG2197@1|root,COG2197@2|Bacteria,2GJKM@201174|Actinobacteria,4ESNK@85013|Frankiales	201174|Actinobacteria	K	Two component transcriptional regulator, LuxR family	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
REGS3_k127_6738236_1	929712.KI912613_gene1690	2.596e-83	295.0	COG4585@1|root,COG4585@2|Bacteria,2IAG1@201174|Actinobacteria,4CR3I@84995|Rubrobacteria	84995|Rubrobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
REGS3_k127_6738236_2	479431.Namu_5018	5.68e-65	228.0	COG2197@1|root,COG2197@2|Bacteria,2GJKM@201174|Actinobacteria,4ESNK@85013|Frankiales	201174|Actinobacteria	K	Two component transcriptional regulator, LuxR family	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
REGS3_k127_6738236_0	1172188.KB911827_gene4224	0.0	1325.0	COG2132@1|root,COG2132@2|Bacteria,2IDP7@201174|Actinobacteria,4FIUQ@85021|Intrasporangiaceae	201174|Actinobacteria	Q	Multicopper oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase_3
REGS3_k127_6738236_3	1077972.ARGLB_080_01420	6.839e-61	220.0	COG2931@1|root,COG4733@1|root,COG5184@1|root,COG2931@2|Bacteria,COG4733@2|Bacteria,COG5184@2|Bacteria,2GKS7@201174|Actinobacteria	201174|Actinobacteria	Q	PFAM Hemolysin-type calcium-binding region	-	-	-	-	-	-	-	-	-	-	-	-	An_peroxidase,HemolysinCabind,Peptidase_M91,fn3
REGS3_k127_6792155_0	1002340.AFCF01000033_gene3890	2.876e-221	725.0	COG0642@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2TX3Q@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HAMP,HATPase_c,HisKA,Hpt,Response_reg,dCache_1
REGS3_k127_6792155_1	1120950.KB892823_gene448	3.009e-07	57.0	COG2197@1|root,COG2197@2|Bacteria,2GN80@201174|Actinobacteria,4DQ84@85009|Propionibacteriales	201174|Actinobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
REGS3_k127_6815247_6	258533.BN977_00751	5.353e-31	130.0	COG2044@1|root,COG2044@2|Bacteria,2HRYF@201174|Actinobacteria,239FX@1762|Mycobacteriaceae	201174|Actinobacteria	S	DsrE/DsrF-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE
REGS3_k127_6815247_8	1449048.JQKU01000025_gene3931	1.142e-27	121.0	COG0425@1|root,COG0425@2|Bacteria,2GSNH@201174|Actinobacteria,23DH9@1762|Mycobacteriaceae	201174|Actinobacteria	O	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
REGS3_k127_6815247_0	675635.Psed_0243	1.388e-186	597.0	COG2197@1|root,COG2206@1|root,COG2197@2|Bacteria,COG2206@2|Bacteria,2GJS8@201174|Actinobacteria,4E26F@85010|Pseudonocardiales	201174|Actinobacteria	KT	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,HD_5
REGS3_k127_6815247_5	1223544.GSI01S_01_02050	1.284e-39	152.0	COG1188@1|root,COG1188@2|Bacteria,2IQ6F@201174|Actinobacteria,4GCHJ@85026|Gordoniaceae	201174|Actinobacteria	J	Protein of unknown function (DUF3558)	hslR	-	-	ko:K04762	-	-	-	-	ko00000,ko03110	-	-	-	S4
REGS3_k127_6815247_3	1229780.BN381_130292	9.467e-67	234.0	293RJ@1|root,2ZR76@2|Bacteria	2|Bacteria	S	Predicted membrane protein (DUF2231)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2231
REGS3_k127_6815247_7	1380394.JADL01000012_gene989	5.844e-28	116.0	COG3461@1|root,COG3461@2|Bacteria,1MZZN@1224|Proteobacteria,2UED8@28211|Alphaproteobacteria,2JTSZ@204441|Rhodospirillales	204441|Rhodospirillales	S	Evidence 4 Homologs of previously reported genes of	-	-	-	ko:K09700	-	-	-	-	ko00000	-	-	-	-
REGS3_k127_6815247_9	479432.Sros_5671	4.685e-13	80.0	COG4974@1|root,COG4974@2|Bacteria,2HU0C@201174|Actinobacteria,4EKQQ@85012|Streptosporangiales	201174|Actinobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_1,Phage_integrase
REGS3_k127_6815247_4	1313172.YM304_04600	1.449e-47	176.0	COG0071@1|root,COG0071@2|Bacteria,2IHVJ@201174|Actinobacteria,4CNC1@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Hsp20/alpha crystallin family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
REGS3_k127_6815247_2	1380347.JNII01000008_gene3981	9.43e-74	263.0	COG2208@1|root,COG2208@2|Bacteria,2GNG4@201174|Actinobacteria	201174|Actinobacteria	KT	phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIE
REGS3_k127_6815247_10	1229909.NSED_00415	0.0004154	50.0	COG4276@1|root,arCOG04604@2157|Archaea,41SI9@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
REGS3_k127_6815247_1	350054.Mflv_4428	1.093e-98	331.0	28MHV@1|root,2ZAUP@2|Bacteria,2IA17@201174|Actinobacteria,23835@1762|Mycobacteriaceae	201174|Actinobacteria	S	Tocopherol cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Tocopherol_cycl
REGS3_k127_6872018_2	1313172.YM304_15380	2.631e-104	351.0	COG3394@1|root,COG3394@2|Bacteria,2HG9M@201174|Actinobacteria,4CN7Z@84992|Acidimicrobiia	84992|Acidimicrobiia	G	YdjC-like protein	-	-	3.5.1.105	ko:K03478	-	-	-	-	ko00000,ko01000	-	-	-	YdjC
REGS3_k127_6872018_4	1313172.YM304_15390	1.578e-46	174.0	COG1525@1|root,COG1525@2|Bacteria,2GRK1@201174|Actinobacteria	201174|Actinobacteria	L	nuclease	-	-	3.1.31.1	ko:K01174,ko:K07038	-	-	-	-	ko00000,ko01000	-	-	-	SNase
REGS3_k127_6872018_1	1313172.YM304_15410	1.266e-211	661.0	COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria,4CMTJ@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Belongs to the thiolase family	-	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
REGS3_k127_6872018_3	1313172.YM304_15430	9.404e-102	340.0	COG2816@1|root,COG2816@2|Bacteria,2GJZY@201174|Actinobacteria	201174|Actinobacteria	L	NADH pyrophosphatase	nudC	-	3.6.1.22	ko:K03426	ko00760,ko01100,ko04146,map00760,map01100,map04146	-	R00103,R03004,R11104	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX,NUDIX-like,zf-NADH-PPase
REGS3_k127_6872018_0	1313172.YM304_21920	1.626e-263	827.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,2GMMM@201174|Actinobacteria,4CNRU@84992|Acidimicrobiia	84992|Acidimicrobiia	EU	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
REGS3_k127_6872018_5	1415166.NONO_c43940	1.284e-15	81.0	COG2141@1|root,COG2141@2|Bacteria,2GJTP@201174|Actinobacteria,4FZXP@85025|Nocardiaceae	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
REGS3_k127_6888082_8	867903.ThesuDRAFT_00844	2.233e-30	126.0	COG1495@1|root,COG1495@2|Bacteria,1V79S@1239|Firmicutes,253UQ@186801|Clostridia	186801|Clostridia	C	PFAM Disulfide bond formation protein DsbB	-	-	-	ko:K03611	-	-	-	-	ko00000,ko03110	5.A.2.1	-	-	DsbB
REGS3_k127_6888082_0	1313172.YM304_26510	2.974e-278	865.0	COG0318@1|root,COG0318@2|Bacteria	2|Bacteria	IQ	PFAM AMP-dependent synthetase and ligase	pks16	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008144,GO:0008150,GO:0008152,GO:0008610,GO:0008922,GO:0009058,GO:0009987,GO:0015645,GO:0016020,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0016874,GO:0016877,GO:0016878,GO:0017076,GO:0019752,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044403,GO:0044419,GO:0044464,GO:0046394,GO:0051704,GO:0070566,GO:0071704,GO:0071944,GO:0072330,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901576	6.2.1.20	ko:K00666,ko:K01909	ko00071,map00071	-	R01406	RC00014,RC00039	ko00000,ko00001,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C,AMP-binding_C_2
REGS3_k127_6888082_6	502025.Hoch_3112	8.971e-88	301.0	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,42NAQ@68525|delta/epsilon subdivisions,2WJPX@28221|Deltaproteobacteria,2YX68@29|Myxococcales	28221|Deltaproteobacteria	BQ	Histone deacetylase domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Hist_deacetyl
REGS3_k127_6888082_1	1313172.YM304_20970	1.262e-180	570.0	COG2141@1|root,COG2141@2|Bacteria,2GNE9@201174|Actinobacteria	201174|Actinobacteria	C	F420-dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
REGS3_k127_6888082_5	1313172.YM304_20980	7.086e-92	315.0	COG2047@1|root,COG2047@2|Bacteria,2GK8I@201174|Actinobacteria	201174|Actinobacteria	S	PAC2 family	-	-	-	-	-	-	-	-	-	-	-	-	PAC2
REGS3_k127_6888082_2	1123320.KB889669_gene3247	2.296e-108	362.0	COG3173@1|root,COG3173@2|Bacteria,2GJT0@201174|Actinobacteria	201174|Actinobacteria	S	Aminoglycoside phosphotransferase	-	-	-	-	-	-	-	-	-	-	-	-	APH
REGS3_k127_6888082_4	1313172.YM304_20990	4.513e-92	308.0	COG3118@1|root,COG3118@2|Bacteria,2GJ7B@201174|Actinobacteria,4CMY0@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Tetratricopeptide repeat	-	-	-	ko:K05838	-	-	-	-	ko00000,ko03110	-	-	-	TPR_20,Thioredoxin
REGS3_k127_6888082_10	1166018.FAES_5093	3.034e-06	53.0	2C8RN@1|root,32RMQ@2|Bacteria,4NSD0@976|Bacteroidetes,47RVK@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_6888082_7	1313172.YM304_21000	1.229e-52	195.0	COG1555@1|root,COG1555@2|Bacteria,2IQDC@201174|Actinobacteria	201174|Actinobacteria	L	Competence protein ComEA	comEA	-	-	ko:K02237	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	HHH_3,SLBB
REGS3_k127_6888082_3	1313172.YM304_21020	1.658e-105	361.0	COG0658@1|root,COG0658@2|Bacteria,2GJGR@201174|Actinobacteria	201174|Actinobacteria	L	ComEC Rec2-related protein	comEC	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
REGS3_k127_6906000_2	1122182.KB903825_gene737	3.246e-50	187.0	COG2335@1|root,COG2335@2|Bacteria,2GJC2@201174|Actinobacteria,4DCPB@85008|Micromonosporales	201174|Actinobacteria	M	Four repeated domains in the Fasciclin I family of proteins, present in many other contexts.	-	-	-	-	-	-	-	-	-	-	-	-	Fasciclin
REGS3_k127_6906000_0	953739.SVEN_0400	4.224e-143	473.0	COG2041@1|root,COG2041@2|Bacteria,2GMG2@201174|Actinobacteria	201174|Actinobacteria	M	Oxidoreductase molybdopterin binding	-	-	-	-	-	-	-	-	-	-	-	-	Mo-co_dimer,Oxidored_molyb
REGS3_k127_6906000_1	1385521.N803_04960	1.654e-52	197.0	COG1595@1|root,COG1595@2|Bacteria,2GP9D@201174|Actinobacteria,4FFIW@85021|Intrasporangiaceae	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	sigK	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
REGS3_k127_6906000_3	1445613.JALM01000009_gene728	4.898e-15	81.0	COG5343@1|root,COG5343@2|Bacteria,2I8NI@201174|Actinobacteria,4E4IM@85010|Pseudonocardiales	201174|Actinobacteria	S	Anti-sigma-K factor rskA	-	-	-	-	-	-	-	-	-	-	-	-	RskA,zf-HC2
REGS3_k127_6912018_3	394.NGR_c20520	1.004e-30	122.0	COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,2TUVG@28211|Alphaproteobacteria,4BIKU@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	alcohol dehydrogenase	-	-	1.1.1.1	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
REGS3_k127_6912018_5	1137271.AZUM01000001_gene1617	0.000169	53.0	COG3595@1|root,COG3595@2|Bacteria,2HIX2@201174|Actinobacteria,4DYUW@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097
REGS3_k127_6912018_4	468556.AQYG01000037_gene2724	2.848e-17	95.0	COG2114@1|root,COG2114@2|Bacteria,2I900@201174|Actinobacteria,4GBPR@85026|Gordoniaceae	201174|Actinobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1647	Guanylate_cyc
REGS3_k127_6912018_2	1123320.KB889668_gene3364	1.18e-37	158.0	COG2267@1|root,COG2267@2|Bacteria,2I7DU@201174|Actinobacteria	201174|Actinobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
REGS3_k127_6912018_0	488538.SAR116_0312	4.453e-197	627.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,4BPJF@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Aldehyde dehydrogenase family	aldA	-	1.2.1.99	ko:K00138,ko:K09472	ko00010,ko00330,ko00620,ko01100,ko01110,ko01120,map00010,map00330,map00620,map01100,map01110,map01120	M00136	R00711,R07417,R07418	RC00047,RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
REGS3_k127_6912018_1	378806.STAUR_6873	6.087e-76	260.0	COG1741@1|root,COG1741@2|Bacteria,1MWIP@1224|Proteobacteria,42UHA@68525|delta/epsilon subdivisions,2WQA0@28221|Deltaproteobacteria,2YUHZ@29|Myxococcales	28221|Deltaproteobacteria	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
REGS3_k127_6932302_7	1463926.JOCA01000021_gene6481	1.542e-37	147.0	COG1477@1|root,COG1477@2|Bacteria,2GN6F@201174|Actinobacteria	201174|Actinobacteria	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	apbE2	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
REGS3_k127_6932302_9	1121946.AUAX01000023_gene4225	6.139e-16	87.0	COG3976@1|root,COG3976@2|Bacteria,2GTTI@201174|Actinobacteria,4DG77@85008|Micromonosporales	201174|Actinobacteria	S	FMN_bind	-	-	-	-	-	-	-	-	-	-	-	-	FMN_bind
REGS3_k127_6932302_4	1380390.JIAT01000011_gene2397	1.625e-75	271.0	COG4097@1|root,COG4097@2|Bacteria,2GKWX@201174|Actinobacteria,4CRXT@84995|Rubrobacteria	84995|Rubrobacteria	P	FAD-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_8,Ferric_reduct,NAD_binding_1
REGS3_k127_6932302_2	1114959.SZMC14600_15817	3.245e-130	427.0	COG1473@1|root,COG1473@2|Bacteria,2GK05@201174|Actinobacteria,4E039@85010|Pseudonocardiales	201174|Actinobacteria	S	PFAM Peptidase family M20 M25 M40	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
REGS3_k127_6932302_3	1229780.BN381_10051	1.436e-88	297.0	COG0491@1|root,COG0491@2|Bacteria,2GJ7I@201174|Actinobacteria,3UXAD@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	blaB4	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
REGS3_k127_6932302_0	1229780.BN381_50083	1.732e-180	570.0	COG1062@1|root,COG1062@2|Bacteria,2GM8C@201174|Actinobacteria,3UX37@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	Alcohol dehydrogenase GroES-like domain	adhC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	1.1.1.306	ko:K00153	-	-	R09129,R10301	RC00069,RC01715	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
REGS3_k127_6932302_5	1313172.YM304_42310	7.058e-61	220.0	COG0596@1|root,COG0596@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on ester bonds	-	-	3.4.16.4	ko:K01286	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_1,Abhydrolase_6
REGS3_k127_6932302_1	1229780.BN381_640027	1.814e-136	449.0	COG1092@1|root,COG1092@2|Bacteria,2GXDD@201174|Actinobacteria	201174|Actinobacteria	J	Methyltransferase	-	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
REGS3_k127_6932302_8	1120936.KB907212_gene5244	1.001e-34	136.0	COG0346@1|root,COG0346@2|Bacteria,2I2S6@201174|Actinobacteria	201174|Actinobacteria	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_6932302_10	1313172.YM304_11290	1.381e-10	62.0	COG1403@1|root,COG1403@2|Bacteria,2ICGQ@201174|Actinobacteria	201174|Actinobacteria	V	Domain of unknown function (DUF222)	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
REGS3_k127_6932302_6	1313172.YM304_06560	1.895e-48	184.0	COG1403@1|root,COG1403@2|Bacteria	2|Bacteria	V	endonuclease activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
REGS3_k127_6938729_8	1172188.KB911822_gene1044	4.024e-05	51.0	COG2132@1|root,COG2132@2|Bacteria,2IN7A@201174|Actinobacteria,4FIGB@85021|Intrasporangiaceae	201174|Actinobacteria	Q	Multicopper oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase_2,Cu-oxidase_3
REGS3_k127_6938729_6	478801.Ksed_14660	4.315e-16	89.0	COG0053@1|root,COG0053@2|Bacteria,2GQJJ@201174|Actinobacteria	201174|Actinobacteria	P	Pfam Cation efflux	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux
REGS3_k127_6938729_4	1370125.AUWT01000020_gene4656	4.816e-53	194.0	2D663@1|root,32TKM@2|Bacteria,2I9AK@201174|Actinobacteria,23536@1762|Mycobacteriaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_6938729_0	469383.Cwoe_1310	5.424e-101	339.0	COG2267@1|root,COG2267@2|Bacteria,2GJ78@201174|Actinobacteria,4CSBE@84995|Rubrobacteria	84995|Rubrobacteria	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
REGS3_k127_6938729_5	1240349.ANGC01000011_gene320	2.197e-42	164.0	COG0716@1|root,COG0716@2|Bacteria,2IQZD@201174|Actinobacteria,4G1CN@85025|Nocardiaceae	201174|Actinobacteria	C	FMN binding	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_1,Flavodoxin_5
REGS3_k127_6938729_1	420324.KI912064_gene6645	1.826e-94	318.0	COG0426@1|root,COG0426@2|Bacteria,1MXIE@1224|Proteobacteria,2U3GM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
REGS3_k127_6938729_2	1123024.AUII01000009_gene1954	5.981e-63	225.0	2A651@1|root,30UXH@2|Bacteria,2IERM@201174|Actinobacteria,4EBDG@85010|Pseudonocardiales	201174|Actinobacteria	S	Mycothiol maleylpyruvate isomerase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_N
REGS3_k127_6938729_3	443218.AS9A_2840	5.079e-54	197.0	COG1309@1|root,COG1309@2|Bacteria,2IMHK@201174|Actinobacteria	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
REGS3_k127_6938729_7	35754.JNYJ01000005_gene5576	2.86e-09	66.0	2C454@1|root,3440S@2|Bacteria,2GSV4@201174|Actinobacteria,4DG4S@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_6962549_3	1144343.PMI41_04913	5.242e-97	319.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,2TQV0@28211|Alphaproteobacteria,43HZ9@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	NADH flavin oxidoreductase NADH oxidase	stcD	-	-	ko:K21833	-	-	-	-	ko00000	-	-	-	NAD_binding_8,Oxidored_FMN,Pyr_redox_2
REGS3_k127_6962549_0	1380391.JIAS01000012_gene3997	1.206e-221	698.0	COG5598@1|root,COG5598@2|Bacteria,1MWJN@1224|Proteobacteria,2TR0V@28211|Alphaproteobacteria,2JRHD@204441|Rhodospirillales	28211|Alphaproteobacteria	H	Trimethylamine methyltransferase (MTTB)	-	-	2.1.1.250	ko:K14083	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09124,R10016	RC00035,RC00732,RC01144,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	MTTB
REGS3_k127_6962549_1	1504672.669786111	3.395e-180	570.0	COG4948@1|root,COG4948@2|Bacteria,1MW5B@1224|Proteobacteria,2VK18@28216|Betaproteobacteria	28216|Betaproteobacteria	M	mandelate racemase muconate lactonizing	-	-	5.5.1.1	ko:K01856	ko00361,ko00362,ko00364,ko00623,ko01100,ko01120,ko01220,map00361,map00362,map00364,map00623,map01100,map01120,map01220	M00568	R05300,R05390,R06989,R08116,R09229	RC00903,RC01038,RC01108,RC01321,RC01356	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
REGS3_k127_6962549_7	298653.Franean1_6683	8.39e-20	96.0	COG1309@1|root,COG1309@2|Bacteria,2I9F9@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
REGS3_k127_6962549_2	1313172.YM304_05040	8.18e-113	372.0	COG2047@1|root,COG2047@2|Bacteria,2I2H9@201174|Actinobacteria,4CN4A@84992|Acidimicrobiia	84992|Acidimicrobiia	S	PAC2 family	-	-	-	-	-	-	-	-	-	-	-	-	PAC2
REGS3_k127_6962549_4	929712.KI912613_gene2340	1.453e-52	194.0	COG0526@1|root,COG0526@2|Bacteria,2HZTZ@201174|Actinobacteria	201174|Actinobacteria	CO	COG0526, thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
REGS3_k127_6962549_6	710111.FraQA3DRAFT_6069	1.722e-30	123.0	COG0526@1|root,COG0526@2|Bacteria,2HZTZ@201174|Actinobacteria	201174|Actinobacteria	CO	COG0526, thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
REGS3_k127_6962549_5	1313172.YM304_13660	1.021e-48	178.0	COG1846@1|root,COG1846@2|Bacteria,2GMDI@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_6966259_1	1313172.YM304_10890	1.4e-217	683.0	COG0312@1|root,COG0312@2|Bacteria,2GJ4E@201174|Actinobacteria,4CNKK@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Putative modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
REGS3_k127_6966259_3	1313172.YM304_10870	2.697e-61	222.0	COG0671@1|root,COG0671@2|Bacteria,2GMYU@201174|Actinobacteria	201174|Actinobacteria	I	PAP2 superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PAP2_3
REGS3_k127_6966259_4	1003195.SCAT_4681	5.881e-42	173.0	COG1807@1|root,COG1807@2|Bacteria,2GP96@201174|Actinobacteria	201174|Actinobacteria	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
REGS3_k127_6966259_0	1313172.YM304_12280	7.056e-300	931.0	COG1154@1|root,COG1154@2|Bacteria,2GMFA@201174|Actinobacteria,4CMS4@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
REGS3_k127_6966259_2	1313172.YM304_12240	7.853e-83	287.0	COG0483@1|root,COG0483@2|Bacteria,2GKZZ@201174|Actinobacteria	201174|Actinobacteria	G	inositol monophosphatase	hisN	-	3.1.3.15,3.1.3.25	ko:K01092,ko:K05602	ko00340,ko00521,ko00562,ko01100,ko01110,ko01230,ko04070,map00340,map00521,map00562,map01100,map01110,map01230,map04070	M00026,M00131	R01185,R01186,R01187,R03013	RC00017,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
REGS3_k127_6974499_3	367299.JOEE01000001_gene1546	1.911e-191	603.0	COG0578@1|root,COG0578@2|Bacteria,2GJKN@201174|Actinobacteria,4FEIW@85021|Intrasporangiaceae	201174|Actinobacteria	C	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family	-	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,DAO_C
REGS3_k127_6974499_8	1449068.JMLQ01000006_gene1585	2.596e-77	265.0	COG0412@1|root,COG0412@2|Bacteria,2GNWB@201174|Actinobacteria,4FW2S@85025|Nocardiaceae	201174|Actinobacteria	Q	Dienelactone hydrolase family	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
REGS3_k127_6974499_6	1229780.BN381_210022	6.987e-137	454.0	COG1506@1|root,COG1506@2|Bacteria,2I5V8@201174|Actinobacteria	201174|Actinobacteria	E	Peptidase S15	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	Peptidase_S15
REGS3_k127_6974499_4	1380394.JADL01000003_gene5177	6.907e-170	541.0	COG3938@1|root,COG3938@2|Bacteria,1N02K@1224|Proteobacteria,2VGM8@28211|Alphaproteobacteria,2JSDZ@204441|Rhodospirillales	204441|Rhodospirillales	E	Proline racemase	-	-	-	-	-	-	-	-	-	-	-	-	Pro_racemase
REGS3_k127_6974499_0	1304865.JAGF01000001_gene1065	7.706e-260	818.0	COG0480@1|root,COG0480@2|Bacteria,2GKRU@201174|Actinobacteria,4F323@85016|Cellulomonadaceae	201174|Actinobacteria	J	elongation factor Tu domain 2 protein	fusA2	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0030312,GO:0044237,GO:0044464,GO:0071944	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
REGS3_k127_6974499_7	367299.JOEE01000002_gene2603	3.511e-108	363.0	COG3000@1|root,COG3000@2|Bacteria,2GMF0@201174|Actinobacteria,4FGHB@85021|Intrasporangiaceae	201174|Actinobacteria	I	Fatty acid hydroxylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
REGS3_k127_6974499_1	557599.MKAN_07990	1.187e-210	665.0	COG2072@1|root,COG2072@2|Bacteria,2GJEA@201174|Actinobacteria,23361@1762|Mycobacteriaceae	201174|Actinobacteria	P	flavoprotein involved in K transport	-	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	FMO-like,K_oxygenase,Pyr_redox_3
REGS3_k127_6974499_5	357808.RoseRS_4538	7.254e-146	472.0	COG0667@1|root,COG0667@2|Bacteria,2G5V3@200795|Chloroflexi,377XZ@32061|Chloroflexia	32061|Chloroflexia	C	PFAM aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
REGS3_k127_6974499_9	1313172.YM304_29260	1.105e-35	147.0	COG4339@1|root,COG4339@2|Bacteria,2GMYQ@201174|Actinobacteria	201174|Actinobacteria	L	nUDIX hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4031,HD
REGS3_k127_6974499_2	1032480.MLP_20320	9.367e-197	622.0	COG0006@1|root,COG0006@2|Bacteria,2H45Q@201174|Actinobacteria,4DP50@85009|Propionibacteriales	201174|Actinobacteria	E	Metallopeptidase family M24	-	-	-	-	-	-	-	-	-	-	-	-	Creatinase_N,Peptidase_M24
REGS3_k127_7022919_3	2045.KR76_02590	7.93e-143	466.0	COG0665@1|root,COG0665@2|Bacteria,2GPX6@201174|Actinobacteria,4DWPJ@85009|Propionibacteriales	201174|Actinobacteria	E	Sarcosine oxidase beta subunit	-	-	-	-	-	-	-	-	-	-	-	-	DAO
REGS3_k127_7022919_5	1313172.YM304_02750	2.164e-96	320.0	COG4923@1|root,COG4923@2|Bacteria	2|Bacteria	K	Protein of unknown function (DUF429)	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DUF429
REGS3_k127_7022919_2	1313172.YM304_02740	1.046e-171	546.0	COG2805@1|root,COG2805@2|Bacteria,2I9GT@201174|Actinobacteria,4CNKQ@84992|Acidimicrobiia	84992|Acidimicrobiia	NU	Type II/IV secretion system protein	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
REGS3_k127_7022919_6	1313172.YM304_02730	1.997e-82	281.0	COG1989@1|root,COG1989@2|Bacteria,2GJ7K@201174|Actinobacteria,4CP3Z@84992|Acidimicrobiia	84992|Acidimicrobiia	NOU	Type IV leader peptidase family	-	-	3.4.23.43	ko:K02654	-	M00331	-	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2	-	-	DiS_P_DiS,Peptidase_A24
REGS3_k127_7022919_1	1313172.YM304_02720	1.761e-174	555.0	COG1459@1|root,COG1459@2|Bacteria,2GQW0@201174|Actinobacteria,4CNRV@84992|Acidimicrobiia	84992|Acidimicrobiia	U	Type II secretion system (T2SS), protein F	-	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
REGS3_k127_7022919_0	1313172.YM304_02700	3.317e-257	804.0	COG2804@1|root,COG2804@2|Bacteria,2I8C2@201174|Actinobacteria,4CNFH@84992|Acidimicrobiia	84992|Acidimicrobiia	NU	Type II secretion system (T2SS), protein E, N-terminal domain	-	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
REGS3_k127_7022919_7	1313172.YM304_02690	9.057e-59	221.0	COG5185@1|root,COG5185@2|Bacteria	2|Bacteria	D	Phage-related minor tail protein	-	-	-	ko:K15771,ko:K18642,ko:K20444	ko02010,map02010	M00491	-	-	ko00000,ko00001,ko00002,ko01000,ko01005,ko02000,ko04812	3.A.1.1.16,3.A.1.1.2,4.D.1.3	GT2,GT4	-	BPD_transp_1,DUF4175,DivIVA,TMP_2,Tape_meas_lam_C
REGS3_k127_7022919_8	457425.XNR_5389	5.379e-57	206.0	COG1309@1|root,COG1309@2|Bacteria,2GMCG@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
REGS3_k127_7022919_4	1313172.YM304_02680	5.674e-117	389.0	COG0258@1|root,COG0258@2|Bacteria,2H2A3@201174|Actinobacteria	201174|Actinobacteria	L	5'-3' exonuclease, C-terminal SAM fold	-	-	-	-	-	-	-	-	-	-	-	-	5_3_exonuc,5_3_exonuc_N
REGS3_k127_7022919_9	1120954.ATXE01000001_gene1883	3.921e-52	191.0	COG0590@1|root,COG0590@2|Bacteria,2IM3Z@201174|Actinobacteria,4DQP2@85009|Propionibacteriales	201174|Actinobacteria	FJ	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)	tadA	-	3.5.4.1,3.5.4.33	ko:K01485,ko:K11991	ko00240,ko00330,ko01100,map00240,map00330,map01100	-	R00974,R01411,R02922,R10223	RC00074,RC00477,RC00514,RC00809	ko00000,ko00001,ko01000,ko03016	-	-	-	MafB19-deam,dCMP_cyt_deam_1
REGS3_k127_7023643_6	298654.FraEuI1c_2880	4.015e-88	299.0	COG1024@1|root,COG1024@2|Bacteria,2GJ0N@201174|Actinobacteria,4ESJA@85013|Frankiales	201174|Actinobacteria	I	Enoyl-CoA hydratase	-	-	4.2.1.17,4.2.1.18	ko:K01692,ko:K13766	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00036,M00087	R02085,R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115,RC02416	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
REGS3_k127_7023643_7	1229780.BN381_50072	5.044e-86	297.0	28HG7@1|root,2Z7S3@2|Bacteria,2GMJK@201174|Actinobacteria,3UXBU@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_N,Wyosine_form
REGS3_k127_7023643_8	298654.FraEuI1c_2878	6.95e-63	226.0	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	tetR7	-	-	-	-	-	-	-	-	-	-	-	TetR_N,WHG
REGS3_k127_7023643_0	1211815.CBYP010000063_gene1911	5.665e-301	930.0	COG3185@1|root,COG3185@2|Bacteria,2GJNC@201174|Actinobacteria,4EU7X@85013|Frankiales	201174|Actinobacteria	E	Acyclic terpene utilisation family protein AtuA	-	-	-	-	-	-	-	-	-	-	-	-	AtuA
REGS3_k127_7023643_1	1211815.CBYP010000063_gene1912	1.06e-278	871.0	COG4770@1|root,COG4770@2|Bacteria,2GIZP@201174|Actinobacteria	201174|Actinobacteria	I	carboxylase	-	-	6.4.1.4	ko:K01968	ko00280,ko01100,map00280,map01100	M00036	R04138	RC00367,RC00942	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
REGS3_k127_7023643_2	1211815.CBYP010000063_gene1913	1.342e-185	582.0	COG4799@1|root,COG4799@2|Bacteria,2GIRU@201174|Actinobacteria	201174|Actinobacteria	I	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta	-	-	-	-	-	-	-	-	-	-	-	-	Carboxyl_trans
REGS3_k127_7023643_4	1211815.CBYP010000063_gene1913	5.474e-98	328.0	COG4799@1|root,COG4799@2|Bacteria,2GIRU@201174|Actinobacteria	201174|Actinobacteria	I	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta	-	-	-	-	-	-	-	-	-	-	-	-	Carboxyl_trans
REGS3_k127_7023643_3	1313172.YM304_01440	3.37e-171	545.0	COG2070@1|root,COG2070@2|Bacteria,2GKGT@201174|Actinobacteria	201174|Actinobacteria	S	2-nitropropane dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	NMO
REGS3_k127_7023643_5	110319.CF8_2934	2.381e-96	334.0	COG0681@1|root,COG0681@2|Bacteria,2HES2@201174|Actinobacteria,4DUMF@85009|Propionibacteriales	201174|Actinobacteria	U	Concanavalin A-like lectin/glucanases superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,Peptidase_S24
REGS3_k127_7028294_5	649831.L083_7696	6.075e-53	207.0	COG1766@1|root,COG1766@2|Bacteria,2HG9F@201174|Actinobacteria,4DCI7@85008|Micromonosporales	201174|Actinobacteria	N	The M ring may be actively involved in energy transduction	fliF	-	-	ko:K02409	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	YscJ_FliF,YscJ_FliF_C
REGS3_k127_7028294_3	58123.JOFJ01000032_gene20	3.33e-69	248.0	COG1536@1|root,COG1536@2|Bacteria,2GP1H@201174|Actinobacteria	201174|Actinobacteria	N	flagellar motor switch protein FliG	fliG	-	-	ko:K02410	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliG_C,FliG_M,FliG_N
REGS3_k127_7028294_15	382245.ASA_1339	8.486e-06	56.0	COG1317@1|root,COG1317@2|Bacteria,1QD77@1224|Proteobacteria,1T18T@1236|Gammaproteobacteria,1Y4HU@135624|Aeromonadales	135624|Aeromonadales	N	flagellar assembly protein FliH	fliH	-	-	ko:K02411	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	FliH
REGS3_k127_7028294_0	1349820.M707_17205	1.074e-123	413.0	COG1157@1|root,COG1157@2|Bacteria,2GKGV@201174|Actinobacteria,1WAT4@1268|Micrococcaceae	201174|Actinobacteria	NU	ATP synthase alpha/beta family, nucleotide-binding domain	fliI	-	3.6.3.14	ko:K02412	ko02040,map02040	-	-	-	ko00000,ko00001,ko01000,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	ATP-synt_ab,ATP-synt_ab_N
REGS3_k127_7028294_9	1430331.EP10_05025	4.198e-29	124.0	COG0741@1|root,COG0741@2|Bacteria,1V6DD@1239|Firmicutes,4HIWA@91061|Bacilli,1WFBZ@129337|Geobacillus	91061|Bacilli	M	Transglycosylase SLT domain	yjbJ	-	-	-	-	-	-	-	-	-	-	-	SLT
REGS3_k127_7028294_14	1048339.KB913029_gene866	3.562e-11	71.0	COG1843@1|root,COG1843@2|Bacteria,2IQIQ@201174|Actinobacteria,4ETA8@85013|Frankiales	201174|Actinobacteria	N	Flagellar hook capping protein	flgD	-	-	ko:K02389	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlgD
REGS3_k127_7028294_1	1048339.KB913029_gene867	1.178e-91	316.0	COG1749@1|root,COG1749@2|Bacteria,2I62V@201174|Actinobacteria,4ERJI@85013|Frankiales	201174|Actinobacteria	N	Flagellar basal body protein FlaE	flgE	-	-	ko:K02390	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlaE,Flg_bb_rod,Flg_bbr_C
REGS3_k127_7028294_16	1120971.AUCA01000011_gene2962	2.366e-05	50.0	COG1582@1|root,COG1582@2|Bacteria,1VKHB@1239|Firmicutes,4HP2W@91061|Bacilli,27AIN@186823|Alicyclobacillaceae	91061|Bacilli	N	Flagellar protein (FlbD)	flbD	-	-	ko:K02385	-	-	-	-	ko00000,ko02035	-	-	-	FlbD
REGS3_k127_7028294_6	1121428.DESHY_60307___1	9.889e-52	192.0	COG1291@1|root,COG1291@2|Bacteria,1TRH1@1239|Firmicutes,24AEJ@186801|Clostridia,2616S@186807|Peptococcaceae	186801|Clostridia	N	PFAM MotA TolQ ExbB proton channel	motA	-	-	ko:K02556	ko02020,ko02030,ko02040,map02020,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotA_ExbB
REGS3_k127_7028294_8	351607.Acel_0852	1.238e-36	152.0	COG1360@1|root,COG1360@2|Bacteria,2IG81@201174|Actinobacteria,4ESQM@85013|Frankiales	201174|Actinobacteria	N	Membrane MotB of proton-channel complex MotA/MotB	motB	-	-	ko:K02557	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotB_plug,OmpA
REGS3_k127_7028294_10	35754.JNYJ01000057_gene8697	1.16e-18	98.0	COG1868@1|root,COG1868@2|Bacteria,2ICP2@201174|Actinobacteria,4DBUV@85008|Micromonosporales	201174|Actinobacteria	N	Flagellar motor switch protein FliM	fliM	-	-	ko:K02416	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliM,FliMN_C
REGS3_k127_7028294_13	367299.JOEE01000006_gene747	8.122e-12	72.0	COG1886@1|root,COG1886@2|Bacteria,2IGHQ@201174|Actinobacteria,4FJSF@85021|Intrasporangiaceae	201174|Actinobacteria	NU	Type III flagellar switch regulator (C-ring) FliN C-term	fliN	-	-	ko:K02417	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	FliMN_C
REGS3_k127_7028294_4	1048339.KB913029_gene875	8.513e-58	220.0	COG1338@1|root,COG1338@2|Bacteria,2GP63@201174|Actinobacteria,4ERQ3@85013|Frankiales	201174|Actinobacteria	N	Plays a role in the flagellum-specific transport system	fliP	-	-	ko:K02419	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	FliP
REGS3_k127_7028294_11	266940.Krad_1667	1.221e-14	76.0	COG1987@1|root,COG1987@2|Bacteria,2IQ8H@201174|Actinobacteria	201174|Actinobacteria	N	Flagellar biosynthetic protein FliQ	fliQ	-	-	ko:K02420	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_3
REGS3_k127_7028294_12	1026882.MAMP_00964	1.379e-12	77.0	COG1684@1|root,COG1684@2|Bacteria,1NIF4@1224|Proteobacteria,1RMYW@1236|Gammaproteobacteria,460QQ@72273|Thiotrichales	72273|Thiotrichales	N	Role in flagellar biosynthesis	-	-	-	ko:K02421	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_1
REGS3_k127_7028294_7	1158338.JNLJ01000002_gene20	5.015e-43	171.0	COG1377@1|root,COG1377@2|Bacteria,2G3XI@200783|Aquificae	200783|Aquificae	N	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin	flhB	-	-	ko:K02401	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_2
REGS3_k127_7028294_2	373903.Hore_16680	6.339e-91	310.0	COG1298@1|root,COG1298@2|Bacteria,1TQBM@1239|Firmicutes,248F5@186801|Clostridia,3WABD@53433|Halanaerobiales	186801|Clostridia	N	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin	flhA	-	-	ko:K02400	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	FHIPEP
REGS3_k127_7079481_8	1121272.KB903259_gene6521	9.465e-17	89.0	COG2304@1|root,COG2304@2|Bacteria,2IB9H@201174|Actinobacteria,4DHKY@85008|Micromonosporales	201174|Actinobacteria	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,Gram_pos_anchor,VWA
REGS3_k127_7079481_4	1144305.PMI02_04253	6.719e-51	192.0	COG1028@1|root,COG1028@2|Bacteria,1MYAK@1224|Proteobacteria,2UPZ2@28211|Alphaproteobacteria,2K9AW@204457|Sphingomonadales	204457|Sphingomonadales	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
REGS3_k127_7079481_3	1487953.JMKF01000050_gene1951	1.729e-55	198.0	COG2947@1|root,COG2947@2|Bacteria,1G5R2@1117|Cyanobacteria,1HB0M@1150|Oscillatoriales	1117|Cyanobacteria	S	COGs COG2947 conserved	-	-	-	-	-	-	-	-	-	-	-	-	EVE
REGS3_k127_7079481_6	911239.CF149_12975	1.104e-47	186.0	COG4221@1|root,COG4221@2|Bacteria,1PH8K@1224|Proteobacteria,1RPDR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
REGS3_k127_7079481_1	1313172.YM304_22820	4.606e-87	291.0	2CGIK@1|root,33UPP@2|Bacteria,2H4PB@201174|Actinobacteria,4CN1M@84992|Acidimicrobiia	84992|Acidimicrobiia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_7079481_5	1229780.BN381_330121	1.113e-48	184.0	COG0483@1|root,COG0483@2|Bacteria	2|Bacteria	G	inositol monophosphate 1-phosphatase activity	-	-	3.1.3.25,3.1.3.7	ko:K01082,ko:K01092	ko00521,ko00562,ko00920,ko01100,ko01120,ko01130,ko04070,map00521,map00562,map00920,map01100,map01120,map01130,map04070	M00131	R00188,R00508,R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	Inositol_P
REGS3_k127_7079481_2	1122611.KB904018_gene7057	1.362e-79	276.0	COG0568@1|root,COG0568@2|Bacteria,2GK3Z@201174|Actinobacteria,4EG2W@85012|Streptosporangiales	201174|Actinobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
REGS3_k127_7079481_0	1120949.KB903299_gene5910	7.044e-98	325.0	COG2070@1|root,COG2070@2|Bacteria,2GKGT@201174|Actinobacteria,4D9WZ@85008|Micromonosporales	201174|Actinobacteria	S	Nitronate monooxygenase	-	-	1.13.12.16	ko:K00459	ko00910,map00910	-	R00025	RC02541,RC02759	ko00000,ko00001,ko01000	-	-	-	NMO
REGS3_k127_7079612_32	1313172.YM304_29790	2.153e-29	119.0	COG1835@1|root,COG2845@1|root,COG1835@2|Bacteria,COG2845@2|Bacteria,2GKI5@201174|Actinobacteria,4CNC6@84992|Acidimicrobiia	201174|Actinobacteria	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
REGS3_k127_7079612_29	1229780.BN381_780003	1.129e-32	132.0	COG2050@1|root,COG2050@2|Bacteria	2|Bacteria	Q	thiolester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
REGS3_k127_7079612_0	1313172.YM304_26210	0.0	1022.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,2GKN1@201174|Actinobacteria,4CMW5@84992|Acidimicrobiia	201174|Actinobacteria	CJ	CoA binding domain	acdA1	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
REGS3_k127_7079612_15	1313172.YM304_26190	4.135e-91	317.0	COG2027@1|root,COG2027@2|Bacteria,2GJPH@201174|Actinobacteria	201174|Actinobacteria	M	D-alanyl-D-alanine carboxypeptidase	-	-	3.4.16.4	ko:K07259	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	Peptidase_S13
REGS3_k127_7079612_23	1313172.YM304_26180	6.72e-58	211.0	COG2802@1|root,COG2802@2|Bacteria,2GNWA@201174|Actinobacteria	201174|Actinobacteria	S	Peptidase S16, lon domain protein	-	-	3.4.21.53	ko:K01338,ko:K07157	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	LON_substr_bdg
REGS3_k127_7079612_35	1313172.YM304_26170	4.04e-23	106.0	28R1E@1|root,2ZDG1@2|Bacteria,2HDQB@201174|Actinobacteria,4CNE2@84992|Acidimicrobiia	84992|Acidimicrobiia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Phage_holin_3_6
REGS3_k127_7079612_39	1313172.YM304_26140	4.032e-18	87.0	COG2104@1|root,COG2104@2|Bacteria,2H07J@201174|Actinobacteria	201174|Actinobacteria	H	ThiS family	-	-	-	ko:K03154	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
REGS3_k127_7079612_6	1313172.YM304_26130	5.052e-153	489.0	COG0037@1|root,COG0037@2|Bacteria,2I9QA@201174|Actinobacteria	201174|Actinobacteria	D	PP-loop family	-	-	2.8.1.15	ko:K21947	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3
REGS3_k127_7079612_11	1313172.YM304_26120	6.934e-118	387.0	COG2519@1|root,COG2519@2|Bacteria,2GJPD@201174|Actinobacteria,4CN0Z@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA	trmI	-	2.1.1.219,2.1.1.220	ko:K07442	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	GCD14,GCD14_N
REGS3_k127_7079612_27	1313172.YM304_26100	2.327e-40	150.0	COG1141@1|root,COG1141@2|Bacteria,2IKKX@201174|Actinobacteria,4CN8X@84992|Acidimicrobiia	84992|Acidimicrobiia	C	4Fe-4S single cluster domain of Ferredoxin I	-	-	-	ko:K05337	-	-	-	-	ko00000	-	-	-	Fer4_15
REGS3_k127_7079612_1	1313172.YM304_26090	4.162e-297	919.0	COG1222@1|root,COG1222@2|Bacteria,2GMR1@201174|Actinobacteria,4CMRU@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Proteasomal ATPase OB/ID domain	arc	-	-	ko:K13527	ko03050,map03050	M00342	-	-	ko00000,ko00001,ko00002,ko03051	-	-	-	AAA,Prot_ATP_ID_OB
REGS3_k127_7079612_5	1313172.YM304_26070	2.919e-240	755.0	COG4122@1|root,COG4122@2|Bacteria,2GJGI@201174|Actinobacteria,4CMSZ@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Pup-ligase protein	dop	-	3.5.1.119	ko:K20814	-	-	-	-	ko00000,ko01000,ko03051	-	-	-	Pup_ligase
REGS3_k127_7079612_38	1313172.YM304_26060	8.479e-19	89.0	2E9C2@1|root,333JS@2|Bacteria,2HGHP@201174|Actinobacteria,4CNEV@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation	pup	-	-	ko:K13570	-	-	-	-	ko00000,ko04121	-	-	-	Pup
REGS3_k127_7079612_9	1313172.YM304_26050	1.288e-123	400.0	COG0638@1|root,COG0638@2|Bacteria,2GJ60@201174|Actinobacteria,4CMX8@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	prcB	-	3.4.25.1	ko:K03433	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
REGS3_k127_7079612_13	1313172.YM304_26040	3.652e-97	329.0	COG0638@1|root,COG0638@2|Bacteria,2GKZ1@201174|Actinobacteria,4CMY5@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	prcA	-	3.4.25.1	ko:K03432	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
REGS3_k127_7079612_2	1313172.YM304_26020	1.058e-277	859.0	COG0638@1|root,COG0638@2|Bacteria,2GMC6@201174|Actinobacteria,4CMS0@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine	pafA	-	6.3.1.19	ko:K13571	-	M00342	R11207	RC00090,RC00096	ko00000,ko00002,ko01000,ko03051	-	-	-	Pup_ligase
REGS3_k127_7079612_24	1313172.YM304_26010	1.783e-57	207.0	COG0681@1|root,COG0681@2|Bacteria,2GIYN@201174|Actinobacteria,4CNAZ@84992|Acidimicrobiia	84992|Acidimicrobiia	U	Signal peptidase, peptidase S26	-	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
REGS3_k127_7079612_17	1313172.YM304_26000	1.791e-82	284.0	COG0584@1|root,COG0584@2|Bacteria	2|Bacteria	C	glycerophosphodiester phosphodiesterase activity	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
REGS3_k127_7079612_40	1313172.YM304_25990	5.713e-17	91.0	COG1826@1|root,COG1826@2|Bacteria	2|Bacteria	U	protein secretion	tatB	GO:0003674,GO:0005215	-	ko:K03116,ko:K03117	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
REGS3_k127_7079612_16	1313172.YM304_25980	7.966e-90	304.0	COG0805@1|root,COG0805@2|Bacteria,2GJK8@201174|Actinobacteria,4CN3F@84992|Acidimicrobiia	84992|Acidimicrobiia	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
REGS3_k127_7079612_4	1229780.BN381_400030	1.225e-245	786.0	COG4581@1|root,COG4581@2|Bacteria,2GJEX@201174|Actinobacteria,3UWB3@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	L	DSHCT	helY	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019439,GO:0030312,GO:0034641,GO:0034655,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360,GO:1901361,GO:1901575	-	ko:K03727	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,DSHCT,Helicase_C,rRNA_proc-arch
REGS3_k127_7079612_30	1313172.YM304_25960	4.396e-32	136.0	COG1597@1|root,COG1597@2|Bacteria,2HCNI@201174|Actinobacteria	201174|Actinobacteria	I	lipid kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_7079612_22	504728.K649_08630	5.406e-60	220.0	COG0604@1|root,COG0604@2|Bacteria,1WI1Y@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	COG0604 NADPH quinone reductase and related Zn-dependent	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
REGS3_k127_7079612_10	1229780.BN381_400028	7.104e-119	399.0	COG1473@1|root,COG1473@2|Bacteria,2GNEG@201174|Actinobacteria	201174|Actinobacteria	S	Peptidase, M20	amiB1	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
REGS3_k127_7079612_3	1313172.YM304_25950	5.764e-276	857.0	COG1351@1|root,COG1351@2|Bacteria,2HBYZ@201174|Actinobacteria,4CMUK@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant	-	-	-	-	-	-	-	-	-	-	-	-	Thy1
REGS3_k127_7079612_33	1313172.YM304_25940	3.072e-27	117.0	2DDS5@1|root,2ZJ1Y@2|Bacteria,2HDMP@201174|Actinobacteria,4CP3T@84992|Acidimicrobiia	84992|Acidimicrobiia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_7079612_37	1313172.YM304_25920	4.166e-21	98.0	COG0454@1|root,COG0456@2|Bacteria,2HBQK@201174|Actinobacteria	201174|Actinobacteria	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
REGS3_k127_7079612_8	1313172.YM304_25910	4.765e-126	415.0	COG1024@1|root,COG1024@2|Bacteria,2GKJ6@201174|Actinobacteria,4CNVN@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
REGS3_k127_7079612_14	1313172.YM304_25900	7.406e-93	325.0	2F1PM@1|root,33UPX@2|Bacteria,2H4R3@201174|Actinobacteria,4CN41@84992|Acidimicrobiia	84992|Acidimicrobiia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_7079612_21	1313172.YM304_25880	1.694e-60	225.0	COG0663@1|root,COG0663@2|Bacteria,2GP22@201174|Actinobacteria,4CN21@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Bacterial transferase hexapeptide (six repeats)	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
REGS3_k127_7079612_26	1313172.YM304_09970	3.03e-50	189.0	COG2264@1|root,COG2264@2|Bacteria,2GW3S@201174|Actinobacteria	201174|Actinobacteria	J	Ribosomal protein L11 methyltransferase (PrmA)	prmA	-	-	ko:K02687	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PrmA
REGS3_k127_7079612_18	1313172.YM304_25870	1.306e-71	255.0	COG0524@1|root,COG0524@2|Bacteria,2I04R@201174|Actinobacteria	201174|Actinobacteria	G	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway	rbsK	-	2.7.1.15	ko:K00852	ko00030,map00030	-	R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
REGS3_k127_7079612_12	1333998.M2A_2103	8.282e-99	329.0	COG1024@1|root,COG1024@2|Bacteria,1R9U5@1224|Proteobacteria,2TWN0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
REGS3_k127_7079612_7	1313172.YM304_25830	2.1e-127	417.0	COG2008@1|root,COG2008@2|Bacteria,2GJ0V@201174|Actinobacteria	201174|Actinobacteria	E	Threonine aldolase	ltaE	-	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	-	R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
REGS3_k127_7079612_25	321332.CYB_1854	7.711e-51	192.0	COG2175@1|root,COG2175@2|Bacteria	2|Bacteria	Q	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	-	-	1.14.11.21	ko:K12675	ko00331,ko01130,map00331,map01130	M00674	R05466,R05468,R05469	RC00773,RC01390,RC01391	ko00000,ko00001,ko00002,ko01000	-	-	-	TauD
REGS3_k127_7079612_36	1089551.KE386572_gene2601	4.096e-23	109.0	COG1737@1|root,COG1737@2|Bacteria,1N3YS@1224|Proteobacteria,2TTJD@28211|Alphaproteobacteria,4BQBU@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	K	Helix-turn-helix domain, rpiR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_6,SIS
REGS3_k127_7079612_31	1538295.JY96_00975	2.932e-30	125.0	2DDX0@1|root,32U27@2|Bacteria,1N2PV@1224|Proteobacteria,2VUXJ@28216|Betaproteobacteria,1KMJ7@119065|unclassified Burkholderiales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_7079612_45	1121904.ARBP01000018_gene2629	5.116e-08	59.0	COG1359@1|root,COG1359@2|Bacteria,4NWZ8@976|Bacteroidetes,47SDI@768503|Cytophagia	976|Bacteroidetes	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
REGS3_k127_7079612_42	66869.JNXG01000004_gene2485	1.668e-12	78.0	COG2755@1|root,COG2755@2|Bacteria,2GMDE@201174|Actinobacteria,418TT@629295|Streptomyces griseus group	201174|Actinobacteria	E	GDSL-like Lipase/Acylhydrolase	plb1	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL,Lipase_GDSL_2
REGS3_k127_7079612_20	326424.FRAAL3586	9.506e-63	226.0	COG3266@1|root,COG3266@2|Bacteria,2HMYI@201174|Actinobacteria	201174|Actinobacteria	S	PAP2 superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PAP2_3
REGS3_k127_7079612_19	1121380.JNIW01000002_gene2238	1.635e-67	239.0	COG0454@1|root,COG0456@2|Bacteria,1WJ43@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	K	PFAM Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
REGS3_k127_7079612_41	489825.LYNGBM3L_06480	1.112e-14	82.0	COG2159@1|root,COG2159@2|Bacteria,1G3DV@1117|Cyanobacteria,1H964@1150|Oscillatoriales	1117|Cyanobacteria	S	TIM-barrel fold metal-dependent hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
REGS3_k127_7085169_0	1449069.JMLO01000008_gene3443	2.138e-101	333.0	COG0262@1|root,COG0262@2|Bacteria,2GMZV@201174|Actinobacteria,4FYCK@85025|Nocardiaceae	201174|Actinobacteria	H	RibD C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
REGS3_k127_7085169_5	1122917.KB899670_gene4312	1.053e-41	158.0	COG0251@1|root,COG0251@2|Bacteria,1V6G4@1239|Firmicutes,4HMTM@91061|Bacilli,26XE2@186822|Paenibacillaceae	91061|Bacilli	J	YjgF/chorismate_mutase-like, putative endoribonuclease	-	-	-	-	-	-	-	-	-	-	-	-	YjgF_endoribonc
REGS3_k127_7085169_1	1449069.JMLO01000016_gene3422	3.052e-92	317.0	COG2267@1|root,COG2267@2|Bacteria,2I1RU@201174|Actinobacteria,4G9GP@85025|Nocardiaceae	201174|Actinobacteria	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
REGS3_k127_7085169_2	1123024.AUII01000007_gene4815	3.775e-90	314.0	COG3324@1|root,COG3324@2|Bacteria,2GJFC@201174|Actinobacteria,4E3XB@85010|Pseudonocardiales	201174|Actinobacteria	S	Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	Glyoxalase
REGS3_k127_7085169_4	1123258.AQXZ01000008_gene1315	4.403e-42	159.0	2DWDF@1|root,33ZT1@2|Bacteria,2GU9G@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_7085169_3	644283.Micau_1398	1.776e-50	186.0	COG4122@1|root,COG4122@2|Bacteria,2IG30@201174|Actinobacteria,4DE3H@85008|Micromonosporales	201174|Actinobacteria	S	O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_20,Methyltransf_25
REGS3_k127_7085169_7	1122927.KB895420_gene4206	5.635e-30	118.0	2AKGE@1|root,31B89@2|Bacteria,1TYK3@1239|Firmicutes,4I7QK@91061|Bacilli,26X6P@186822|Paenibacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_7094087_4	1313172.YM304_15670	1.261e-11	65.0	COG2124@1|root,COG2124@2|Bacteria,2GJ8V@201174|Actinobacteria	201174|Actinobacteria	Q	cytochrome p450	-	-	1.14.13.221	ko:K16046	ko00984,ko01120,map00984,map01120	-	R09859,R11361	RC01216,RC03368	ko00000,ko00001,ko00199,ko01000	-	-	-	p450
REGS3_k127_7094087_0	493475.GARC_4235	1.571e-159	526.0	COG3356@1|root,COG3356@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Ceramidase_alk
REGS3_k127_7094087_2	68170.KL590535_gene3743	9.967e-75	254.0	COG2210@1|root,COG2210@2|Bacteria,2IFXH@201174|Actinobacteria,4EABZ@85010|Pseudonocardiales	201174|Actinobacteria	S	DsrE/DsrF/DrsH-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE_2
REGS3_k127_7094087_3	1906.SFRA_26795	2.117e-41	154.0	COG2920@1|root,COG2920@2|Bacteria,2IQB2@201174|Actinobacteria	201174|Actinobacteria	P	PFAM DsrC family protein	-	-	-	ko:K11179	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DsrC
REGS3_k127_7094087_1	1089544.KB912942_gene1571	1.063e-150	482.0	COG0446@1|root,COG0446@2|Bacteria,2GRTN@201174|Actinobacteria,4E527@85010|Pseudonocardiales	201174|Actinobacteria	S	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	DsrC,Pyr_redox_2
REGS3_k127_7117367_2	40571.JOEA01000021_gene6851	4.136e-115	381.0	COG4962@1|root,COG4962@2|Bacteria,2GKKJ@201174|Actinobacteria,4DZ86@85010|Pseudonocardiales	201174|Actinobacteria	U	Type II/IV secretion system protein	-	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
REGS3_k127_7117367_4	909613.UO65_0140	1.208e-46	180.0	COG4965@1|root,COG4965@2|Bacteria,2GN6E@201174|Actinobacteria,4DXBT@85010|Pseudonocardiales	201174|Actinobacteria	U	Type II secretion system (T2SS), protein F	-	-	-	-	-	-	-	-	-	-	-	-	T2SSF
REGS3_k127_7117367_3	1463825.JNXC01000019_gene6509	8.654e-49	189.0	COG2064@1|root,COG2064@2|Bacteria,2HZTC@201174|Actinobacteria,4E0WX@85010|Pseudonocardiales	201174|Actinobacteria	NU	Type II secretion system (T2SS), protein F	-	-	-	-	-	-	-	-	-	-	-	-	T2SSF
REGS3_k127_7117367_7	882083.SacmaDRAFT_5288	1.25e-08	61.0	2EC3E@1|root,3362A@2|Bacteria,2I4V1@201174|Actinobacteria,4E50W@85010|Pseudonocardiales	201174|Actinobacteria	S	TadE-like protein	-	-	-	-	-	-	-	-	-	-	-	-	TadE
REGS3_k127_7117367_6	1449976.KALB_5181	2.565e-10	67.0	COG4961@1|root,COG4961@2|Bacteria,2GRCJ@201174|Actinobacteria,4E4M7@85010|Pseudonocardiales	201174|Actinobacteria	U	PFAM TadE family protein	-	-	-	-	-	-	-	-	-	-	-	-	TadE
REGS3_k127_7117367_5	981369.JQMJ01000004_gene880	4.37e-11	71.0	2E4ST@1|root,3206Y@2|Bacteria,2I1FF@201174|Actinobacteria,2NJEU@228398|Streptacidiphilus	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_7117367_1	1313172.YM304_01270	1.067e-147	501.0	COG1388@1|root,COG1652@1|root,COG1388@2|Bacteria,COG1652@2|Bacteria,2I8YV@201174|Actinobacteria	201174|Actinobacteria	NU	PFAM Peptidoglycan-binding LysM	-	-	-	-	-	-	-	-	-	-	-	-	LysM
REGS3_k127_7117367_0	1313172.YM304_37070	1.738e-183	586.0	COG1066@1|root,COG1066@2|Bacteria,2GMQ0@201174|Actinobacteria,4CNUD@84992|Acidimicrobiia	84992|Acidimicrobiia	O	KaiC	-	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	ATPase
REGS3_k127_7120849_2	1229780.BN381_350095	1.861e-44	169.0	COG0526@1|root,COG0526@2|Bacteria,2H8ZP@201174|Actinobacteria	201174|Actinobacteria	CO	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_7120849_0	1313172.YM304_26580	0.0	1461.0	COG0495@1|root,COG0495@2|Bacteria,2GJI1@201174|Actinobacteria,4CMQM@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1
REGS3_k127_7120849_1	1313172.YM304_24940	1.148e-99	339.0	COG0534@1|root,COG0534@2|Bacteria,2GJE3@201174|Actinobacteria	201174|Actinobacteria	V	MATE efflux family protein	dinF	-	-	-	-	-	-	-	-	-	-	-	MatE
REGS3_k127_7120855_4	1121946.AUAX01000015_gene5994	7.188e-70	237.0	COG2334@1|root,COG2334@2|Bacteria,2GU3Q@201174|Actinobacteria,4D9BZ@85008|Micromonosporales	201174|Actinobacteria	S	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
REGS3_k127_7120855_2	37919.EP51_25010	1.515e-96	320.0	COG0262@1|root,COG0262@2|Bacteria,2GKX0@201174|Actinobacteria,4G172@85025|Nocardiaceae	201174|Actinobacteria	H	RibD C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
REGS3_k127_7120855_1	298655.KI912266_gene1939	1.6e-110	366.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria,4ERP0@85013|Frankiales	201174|Actinobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990,ko:K09695	ko02010,map02010	M00252,M00254	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.102	-	-	ABC_tran,DUF4162
REGS3_k127_7120855_3	298655.KI912266_gene1940	2.899e-76	272.0	COG0842@1|root,COG0842@2|Bacteria,2IART@201174|Actinobacteria	201174|Actinobacteria	V	ABC-type multidrug transport system, permease component	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_3
REGS3_k127_7120855_5	298655.KI912266_gene1941	4.088e-68	247.0	COG0842@1|root,COG0842@2|Bacteria	2|Bacteria	V	Transport permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
REGS3_k127_7120855_6	35754.JNYJ01000101_gene9938	1.252e-38	151.0	COG1846@1|root,COG1846@2|Bacteria,2IKZU@201174|Actinobacteria,4DJ1J@85008|Micromonosporales	201174|Actinobacteria	K	HxlR-like helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	MarR
REGS3_k127_7120855_0	1313172.YM304_22190	6.941e-117	390.0	COG0038@1|root,COG0038@2|Bacteria,2HGV9@201174|Actinobacteria,4CNW2@84992|Acidimicrobiia	84992|Acidimicrobiia	P	Voltage gated chloride channel	-	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	-	Voltage_CLC
REGS3_k127_7140071_9	1313172.YM304_15130	1.452e-69	242.0	COG1804@1|root,COG1804@2|Bacteria,2GIU7@201174|Actinobacteria	201174|Actinobacteria	C	L-carnitine dehydratase bile acid-inducible protein F	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
REGS3_k127_7140071_5	1313172.YM304_29750	3.1e-133	431.0	COG1028@1|root,COG1028@2|Bacteria,2GNUM@201174|Actinobacteria,4CMZC@84992|Acidimicrobiia	84992|Acidimicrobiia	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
REGS3_k127_7140071_4	1313172.YM304_29730	1.989e-145	474.0	COG1364@1|root,COG1364@2|Bacteria,2GIW0@201174|Actinobacteria,4CN30@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	argJ	-	2.3.1.1,2.3.1.35	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgJ
REGS3_k127_7140071_14	1313172.YM304_29720	3.408e-39	152.0	COG1846@1|root,COG1846@2|Bacteria,2H64I@201174|Actinobacteria,4CNCT@84992|Acidimicrobiia	84992|Acidimicrobiia	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2
REGS3_k127_7140071_12	1452536.JARE01000047_gene2422	2.184e-63	223.0	COG2353@1|root,COG2353@2|Bacteria,2GJUB@201174|Actinobacteria,4FNH2@85023|Microbacteriaceae	201174|Actinobacteria	S	Belongs to the UPF0312 family	-	-	-	-	-	-	-	-	-	-	-	-	YceI
REGS3_k127_7140071_13	1449353.JQMQ01000005_gene2595	2.279e-50	184.0	COG0346@1|root,COG0346@2|Bacteria,2IK75@201174|Actinobacteria,2NI6J@228398|Streptacidiphilus	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
REGS3_k127_7140071_6	1313172.YM304_29690	8.485e-119	388.0	COG1090@1|root,COG1090@2|Bacteria,2GJS0@201174|Actinobacteria,4CN0B@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Domain of unknown function (DUF1731)	-	-	-	ko:K07071	-	-	-	-	ko00000	-	-	-	DUF1731,Epimerase
REGS3_k127_7140071_2	1229780.BN381_350018	8.746e-186	599.0	COG0531@1|root,COG0531@2|Bacteria,2GK5V@201174|Actinobacteria,3UX33@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
REGS3_k127_7140071_10	436229.JOEH01000019_gene6594	6.779e-67	235.0	COG0569@1|root,COG0569@2|Bacteria,2GK4N@201174|Actinobacteria,2NGQT@228398|Streptacidiphilus	201174|Actinobacteria	P	TrkA-C domain	ceoB	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
REGS3_k127_7140071_11	525909.Afer_1924	1.453e-64	228.0	COG0569@1|root,COG0569@2|Bacteria,2HH1S@201174|Actinobacteria,4CP21@84992|Acidimicrobiia	84992|Acidimicrobiia	C	TrkA-C domain	-	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
REGS3_k127_7140071_15	471852.Tcur_1708	2.322e-15	80.0	COG1200@1|root,COG1200@2|Bacteria,2IHRX@201174|Actinobacteria,4EJMR@85012|Streptosporangiales	201174|Actinobacteria	KL	Nucleic acid binding, OB-fold, tRNA	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_7140071_16	1440774.Y900_025990	8.81e-15	77.0	COG0526@1|root,COG0526@2|Bacteria,2IR6C@201174|Actinobacteria,238K9@1762|Mycobacteriaceae	201174|Actinobacteria	CO	Soluble secreted antigen Mpt53	mpt53	GO:0003674,GO:0003824,GO:0005575,GO:0005576,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0019725,GO:0042592,GO:0045454,GO:0050789,GO:0050794,GO:0055114,GO:0065007,GO:0065008	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
REGS3_k127_7140071_18	1236902.ANAS01000024_gene3166	0.0001619	49.0	COG0526@1|root,COG0526@2|Bacteria,2IR6C@201174|Actinobacteria,4EPZI@85012|Streptosporangiales	201174|Actinobacteria	CO	AhpC/TSA family	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
REGS3_k127_7140071_0	1313172.YM304_29660	7.933e-227	712.0	COG1249@1|root,COG1249@2|Bacteria,2GIXY@201174|Actinobacteria,4CMT7@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
REGS3_k127_7140071_3	1313172.YM304_29650	3.041e-175	566.0	COG0508@1|root,COG0508@2|Bacteria,2GMUV@201174|Actinobacteria,4CMW0@84992|Acidimicrobiia	84992|Acidimicrobiia	C	e3 binding domain	-	-	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
REGS3_k127_7140071_1	1229780.BN381_210109	3.078e-194	624.0	COG0320@1|root,COG0320@2|Bacteria,2GKD4@201174|Actinobacteria,3UWD6@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
REGS3_k127_7140071_8	1123320.KB889596_gene8695	6.664e-95	325.0	COG0006@1|root,COG0006@2|Bacteria,2GM7D@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the peptidase M24B family	pepE	-	3.4.13.9	ko:K01271,ko:K01274	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
REGS3_k127_7140071_7	1313172.YM304_34000	1.152e-110	359.0	COG0183@1|root,COG0183@2|Bacteria,2GIY0@201174|Actinobacteria	201174|Actinobacteria	I	Belongs to the thiolase family	ltp1_1	-	-	-	-	-	-	-	-	-	-	-	Thiolase_C,Thiolase_N
REGS3_k127_7149225_3	1038860.AXAP01000053_gene7273	6.64e-18	86.0	COG1409@1|root,COG1409@2|Bacteria,1MVDW@1224|Proteobacteria,2TQNM@28211|Alphaproteobacteria,3JS85@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
REGS3_k127_7149225_2	1313172.YM304_38800	1.755e-70	243.0	COG0344@1|root,COG0344@2|Bacteria,2IFX1@201174|Actinobacteria	201174|Actinobacteria	I	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP	-	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
REGS3_k127_7149225_0	1313172.YM304_38790	3.567e-80	277.0	COG1307@1|root,COG1307@2|Bacteria,2GIUV@201174|Actinobacteria	201174|Actinobacteria	S	DegV family	-	-	-	-	-	-	-	-	-	-	-	-	DegV
REGS3_k127_7149225_1	1370120.AUWR01000054_gene2942	4.74e-74	255.0	COG1024@1|root,COG1024@2|Bacteria,2H2U8@201174|Actinobacteria,23AUU@1762|Mycobacteriaceae	201174|Actinobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.17,4.2.1.18	ko:K01692,ko:K13766	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00036,M00087	R02085,R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115,RC02416	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
REGS3_k127_7155050_8	1313172.YM304_27330	5.058e-101	333.0	COG1804@1|root,COG1804@2|Bacteria,2GRB0@201174|Actinobacteria	201174|Actinobacteria	C	L-carnitine dehydratase bile acid-inducible protein F	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
REGS3_k127_7155050_6	1123320.KB889697_gene9013	1.865e-138	456.0	COG0477@1|root,COG2814@2|Bacteria,2GIZX@201174|Actinobacteria	201174|Actinobacteria	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
REGS3_k127_7155050_2	388401.RB2150_11256	5.477e-189	602.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,3ZGIA@58840|unclassified Rhodobacteraceae	28211|Alphaproteobacteria	C	belongs to the aldehyde dehydrogenase family	dhaS	-	1.2.1.3,1.2.1.8	ko:K00128,ko:K00130	ko00010,ko00053,ko00071,ko00260,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00260,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135,M00555	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02565,R02566,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
REGS3_k127_7155050_13	742159.HMPREF0004_5667	6.583e-59	215.0	COG2267@1|root,COG2267@2|Bacteria,1RG43@1224|Proteobacteria,2WETS@28216|Betaproteobacteria	28216|Betaproteobacteria	I	hydrolases or acyltransferases (alpha beta hydrolase superfamily)	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Hydrolase_4
REGS3_k127_7155050_11	1003200.AXXA_05928	1.338e-77	264.0	28I63@1|root,2Z897@2|Bacteria,1N3VY@1224|Proteobacteria,2VNJD@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Amino acid synthesis	-	-	-	-	-	-	-	-	-	-	-	-	AA_synth
REGS3_k127_7155050_5	246200.SPO2707	2.897e-139	450.0	COG2141@1|root,COG2141@2|Bacteria,1MX64@1224|Proteobacteria,2TV8M@28211|Alphaproteobacteria,4NA6V@97050|Ruegeria	28211|Alphaproteobacteria	C	Luciferase-like monooxygenase	limB	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
REGS3_k127_7155050_3	43354.JOIJ01000026_gene3290	2.065e-144	479.0	COG3848@1|root,COG3848@2|Bacteria,2H2J1@201174|Actinobacteria,4EA35@85010|Pseudonocardiales	201174|Actinobacteria	T	PEP-utilising enzyme, mobile domain	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers
REGS3_k127_7155050_0	1313172.YM304_27360	2.341e-250	796.0	COG0661@1|root,COG0661@2|Bacteria,2GJQ6@201174|Actinobacteria,4CMUC@84992|Acidimicrobiia	84992|Acidimicrobiia	S	ABC1 family	-	-	-	-	-	-	-	-	-	-	-	-	ABC1
REGS3_k127_7155050_9	1229780.BN381_10284	2.362e-89	299.0	COG1637@1|root,COG1637@2|Bacteria,2GIYB@201174|Actinobacteria,3UWH6@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	L	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures	nucS	-	-	ko:K07503	-	-	-	-	ko00000,ko01000	-	-	-	NucS
REGS3_k127_7155050_10	1907.SGLAU_31110	2.864e-80	283.0	COG1482@1|root,COG1482@2|Bacteria,2GJXC@201174|Actinobacteria	201174|Actinobacteria	G	mannose-6-phosphate isomerase	manA	-	5.3.1.8	ko:K01809	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01819	RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	PMI_typeI
REGS3_k127_7155050_12	1211815.CBYP010000040_gene2553	1.673e-64	231.0	COG2820@1|root,COG2820@2|Bacteria,2IT3V@201174|Actinobacteria	201174|Actinobacteria	F	Phosphorylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PNP_UDP_1
REGS3_k127_7155050_1	1313172.YM304_27420	8.627e-209	664.0	COG0821@1|root,COG0821@2|Bacteria,2GK2S@201174|Actinobacteria,4CMRA@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	-	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
REGS3_k127_7155050_7	1313172.YM304_27430	3.945e-108	364.0	COG0750@1|root,COG0750@2|Bacteria,2GJJT@201174|Actinobacteria,4CMZX@84992|Acidimicrobiia	84992|Acidimicrobiia	M	Peptidase family M50	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
REGS3_k127_7155050_4	1313172.YM304_27440	5.327e-144	463.0	COG0743@1|root,COG0743@2|Bacteria,2GIRV@201174|Actinobacteria,4CMRC@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	-	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	-	DXPR_C,DXP_redisom_C,DXP_reductoisom
REGS3_k127_7184605_18	981369.JQMJ01000004_gene4890	1.915e-09	61.0	COG2272@1|root,COG2272@2|Bacteria,2GJCN@201174|Actinobacteria,2NM31@228398|Streptacidiphilus	201174|Actinobacteria	I	Carboxylesterase family	-	-	-	ko:K03929	-	-	-	-	ko00000,ko01000	-	CE10	-	COesterase
REGS3_k127_7184605_8	1206732.BAGD01000081_gene3415	7.402e-83	284.0	COG1028@1|root,COG1028@2|Bacteria,2GKI2@201174|Actinobacteria,4FYFT@85025|Nocardiaceae	201174|Actinobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
REGS3_k127_7184605_19	446465.Bfae_19930	0.0004929	49.0	COG1670@1|root,COG1670@2|Bacteria	2|Bacteria	J	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
REGS3_k127_7184605_17	1209072.ALBT01000044_gene2518	3.29e-10	68.0	29A26@1|root,2ZX3K@2|Bacteria,1RFE8@1224|Proteobacteria,1S7AB@1236|Gammaproteobacteria,1FI97@10|Cellvibrio	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_7184605_14	1033736.CAHK01000013_gene998	5.025e-32	134.0	COG1545@1|root,COG1545@2|Bacteria,2HQJU@201174|Actinobacteria,4FB67@85019|Brevibacteriaceae	201174|Actinobacteria	S	DUF35 OB-fold domain, acyl-CoA-associated	-	-	-	-	-	-	-	-	-	-	-	-	DUF35_N,OB_aCoA_assoc
REGS3_k127_7184605_1	450380.JPSY01000001_gene1101	3.853e-180	571.0	COG0183@1|root,COG0183@2|Bacteria,2GKH4@201174|Actinobacteria,4FTIZ@85023|Microbacteriaceae	201174|Actinobacteria	I	Thiolase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Thiolase_C
REGS3_k127_7184605_16	929712.KI912613_gene1694	1.998e-14	80.0	COG3794@1|root,COG3794@2|Bacteria	2|Bacteria	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cupredoxin_1,Cytochrom_C
REGS3_k127_7184605_4	710111.FraQA3DRAFT_4404	1.688e-116	385.0	COG0707@1|root,COG0707@2|Bacteria,2GREI@201174|Actinobacteria,4EWT3@85013|Frankiales	201174|Actinobacteria	M	Monogalactosyldiacylglycerol (MGDG) synthase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1298,Glyco_tran_28_C,Glyco_trans_1_4,MGDG_synth,WES_acyltransf
REGS3_k127_7184605_12	1463855.JOHV01000001_gene1637	2.357e-39	158.0	COG0726@1|root,COG0726@2|Bacteria,2GMC2@201174|Actinobacteria	201174|Actinobacteria	G	PFAM Polysaccharide deacetylase	-	-	3.5.1.104	ko:K22278	-	-	-	-	ko00000,ko01000	-	-	-	Polysacc_deac_1
REGS3_k127_7184605_6	656024.FsymDg_4186	3.336e-93	315.0	COG0451@1|root,COG0451@2|Bacteria,2GK8K@201174|Actinobacteria	201174|Actinobacteria	GM	Epimerase dehydratase	-	-	5.1.3.2,5.1.3.25	ko:K01784,ko:K17947	ko00052,ko00520,ko00523,ko01100,ko01130,map00052,map00520,map00523,map01100,map01130	M00361,M00362,M00632	R00291,R02984,R10279	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
REGS3_k127_7184605_2	1206720.BAFQ01000293_gene6366	4.517e-122	411.0	COG0399@1|root,COG0399@2|Bacteria,2GKD7@201174|Actinobacteria,4G2WJ@85025|Nocardiaceae	201174|Actinobacteria	M	DegT/DnrJ/EryC1/StrS aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
REGS3_k127_7184605_13	1206735.BAGG01000060_gene2449	2.808e-33	139.0	COG0697@1|root,COG0697@2|Bacteria,2GRXH@201174|Actinobacteria,4FX24@85025|Nocardiaceae	201174|Actinobacteria	EG	Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_7184605_9	208444.JNYY01000032_gene3715	5.704e-65	251.0	COG0457@1|root,COG2197@1|root,COG3899@1|root,COG0457@2|Bacteria,COG2197@2|Bacteria,COG3899@2|Bacteria,2I2R1@201174|Actinobacteria,4E20T@85010|Pseudonocardiales	201174|Actinobacteria	K	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
REGS3_k127_7184605_5	369723.Strop_1651	7.29e-113	388.0	COG0443@1|root,COG3266@1|root,COG0443@2|Bacteria,COG3266@2|Bacteria,2GNTE@201174|Actinobacteria,4DM1N@85008|Micromonosporales	201174|Actinobacteria	O	Hsp70 protein	-	-	-	-	-	-	-	-	-	-	-	-	HSP70
REGS3_k127_7184605_10	675635.Psed_6594	8.454e-60	231.0	COG0699@1|root,COG0699@2|Bacteria,2GNGP@201174|Actinobacteria,4DYV2@85010|Pseudonocardiales	201174|Actinobacteria	S	Dynamin family	iniA	GO:0003674,GO:0005215,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0015562,GO:0016020,GO:0022857,GO:0030312,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944	-	-	-	-	-	-	-	-	-	-	Dynamin_N
REGS3_k127_7184605_7	1869.MB27_42735	1.374e-85	302.0	COG0699@1|root,COG0699@2|Bacteria,2GK6T@201174|Actinobacteria,4D9EK@85008|Micromonosporales	201174|Actinobacteria	S	Dynamin family	-	-	-	-	-	-	-	-	-	-	-	-	Dynamin_N,MMR_HSR1
REGS3_k127_7184605_0	298655.KI912266_gene2207	0.0	1157.0	COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4ES40@85013|Frankiales	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
REGS3_k127_7184605_3	1120936.KB907225_gene2778	9.907e-122	404.0	COG2124@1|root,COG2124@2|Bacteria,2HMMY@201174|Actinobacteria	201174|Actinobacteria	Q	cytochrome P450	-	-	-	-	-	-	-	-	-	-	-	-	p450
REGS3_k127_7184605_15	1123073.KB899241_gene3463	1.176e-30	134.0	COG0726@1|root,COG0726@2|Bacteria	2|Bacteria	G	polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Formyl_trans_C,Formyl_trans_N,GHL10,Polysacc_deac_1
REGS3_k127_7184605_11	243231.GSU2073	3.091e-44	174.0	COG3209@1|root,COG3227@1|root,COG3391@1|root,COG3209@2|Bacteria,COG3227@2|Bacteria,COG3391@2|Bacteria,1QW4H@1224|Proteobacteria	1224|Proteobacteria	M	Rhs Family	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Autotransporter,Big_3_2,Big_3_5,DUF4082,DUF4347,He_PIG,PT-HINT,RHS_repeat
REGS3_k127_7198976_4	525904.Tter_1971	3.896e-13	73.0	2DQ8Q@1|root,335AV@2|Bacteria,2NQY5@2323|unclassified Bacteria	2|Bacteria	S	F420H(2)-dependent quinone reductase	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red
REGS3_k127_7198976_0	1313172.YM304_28970	4.366e-265	823.0	COG1884@1|root,COG1884@2|Bacteria,2GM65@201174|Actinobacteria,4CMX5@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
REGS3_k127_7198976_2	1313172.YM304_28980	4.722e-41	161.0	COG0251@1|root,COG0251@2|Bacteria,2IJMC@201174|Actinobacteria	201174|Actinobacteria	J	endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
REGS3_k127_7198976_1	2074.JNYD01000010_gene926	3.999e-124	402.0	COG0235@1|root,COG0235@2|Bacteria,2GJ8W@201174|Actinobacteria,4E37X@85010|Pseudonocardiales	201174|Actinobacteria	G	Class II Aldolase and Adducin N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Aldolase_II
REGS3_k127_7198976_3	1172188.KB911825_gene3643	1.335e-14	84.0	COG3291@1|root,COG3291@2|Bacteria,2H2KA@201174|Actinobacteria,4FIPX@85021|Intrasporangiaceae	201174|Actinobacteria	S	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_7209270_4	1122214.AQWH01000006_gene2407	3.376e-18	92.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,2PKHZ@255475|Aurantimonadaceae	28211|Alphaproteobacteria	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,MHYT,PAS_4,PAS_9
REGS3_k127_7209270_7	1415780.JPOG01000001_gene2335	1.113e-16	94.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_3,PAS_4,PAS_9
REGS3_k127_7209270_0	1282876.BAOK01000001_gene2443	1.693e-48	184.0	COG5031@1|root,COG5031@2|Bacteria,1NN4T@1224|Proteobacteria,2UMSY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Coenzyme Q (ubiquinone) biosynthesis protein Coq4	-	-	-	-	-	-	-	-	-	-	-	-	Coq4
REGS3_k127_7209270_6	446471.Xcel_1092	2.405e-17	90.0	299DI@1|root,2ZWGD@2|Bacteria,2HDMD@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_7209270_1	1095767.CAHD01000037_gene1127	1.865e-48	183.0	2F994@1|root,341K9@2|Bacteria,2IQFJ@201174|Actinobacteria,4F2QR@85016|Cellulomonadaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_7209270_2	1713.JOFV01000006_gene2615	1.49e-40	165.0	COG1725@1|root,COG1725@2|Bacteria,2IQEW@201174|Actinobacteria,4F2T7@85016|Cellulomonadaceae	201174|Actinobacteria	K	helix_turn_helix gluconate operon transcriptional repressor	-	-	-	-	-	-	-	-	-	-	-	-	GntR
REGS3_k127_7209270_3	1246995.AFR_37925	5.242e-19	89.0	28VCT@1|root,2ZHFH@2|Bacteria,2GPRW@201174|Actinobacteria,4DFCX@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_7209270_5	5888.CAK64316	1.563e-17	96.0	COG0664@1|root,KOG0614@2759|Eukaryota,3ZDCZ@5878|Ciliophora	5878|Ciliophora	T	Protein kinase domain	-	-	2.7.11.12	ko:K07376	ko04022,ko04270,ko04540,ko04611,ko04713,ko04714,ko04730,ko04740,ko04923,ko04970,map04022,map04270,map04540,map04611,map04713,map04714,map04730,map04740,map04923,map04970	M00694	-	-	ko00000,ko00001,ko00002,ko01000,ko01001	-	-	-	Pkinase,cNMP_binding
REGS3_k127_7209270_8	67267.JNXT01000027_gene1373	4.878e-11	75.0	COG1994@1|root,COG1994@2|Bacteria,2GMSW@201174|Actinobacteria	201174|Actinobacteria	S	Peptidase M50	-	-	-	ko:K16922	-	-	-	-	ko00000,ko01002	-	-	-	-
REGS3_k127_7213496_0	1313172.YM304_02390	0.0	1115.0	COG3250@1|root,COG3250@2|Bacteria,2GMAT@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase 2 family	-	-	3.2.1.23	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	-	R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000	-	-	-	Bgal_small_N,DUF4981,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
REGS3_k127_7213496_1	1313172.YM304_33870	3.076e-268	859.0	COG3345@1|root,COG3345@2|Bacteria,2GJJ1@201174|Actinobacteria	201174|Actinobacteria	G	alpha-galactosidase	rafA	-	3.2.1.22	ko:K07407	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_36C,Glyco_hydro_36N,Melibiase
REGS3_k127_7213496_3	1449976.KALB_724	1.859e-99	337.0	COG0395@1|root,COG0395@2|Bacteria,2GJNN@201174|Actinobacteria,4E1SW@85010|Pseudonocardiales	201174|Actinobacteria	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
REGS3_k127_7213496_4	446462.Amir_0615	2.058e-75	266.0	COG1175@1|root,COG1175@2|Bacteria,2GKC2@201174|Actinobacteria,4E0AB@85010|Pseudonocardiales	201174|Actinobacteria	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025,ko:K10118	ko02010,map02010	M00196,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.28	-	-	BPD_transp_1
REGS3_k127_7213496_2	644283.Micau_1714	6.919e-129	427.0	COG1653@1|root,COG1653@2|Bacteria,2GP9H@201174|Actinobacteria,4D8I0@85008|Micromonosporales	201174|Actinobacteria	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
REGS3_k127_7213496_5	103733.JNYO01000009_gene4662	4.784e-20	92.0	COG1349@1|root,COG1349@2|Bacteria,2H5X4@201174|Actinobacteria,4DY5K@85010|Pseudonocardiales	201174|Actinobacteria	K	Bacterial regulatory proteins, deoR family	glpR	-	-	-	-	-	-	-	-	-	-	-	DeoRC,HTH_DeoR
REGS3_k127_7220295_11	1278073.MYSTI_02535	1.102e-18	93.0	COG0671@1|root,COG0671@2|Bacteria,1N80J@1224|Proteobacteria,437QM@68525|delta/epsilon subdivisions,2X2Z5@28221|Deltaproteobacteria,2Z25V@29|Myxococcales	28221|Deltaproteobacteria	I	Protein of unknown function (DUF3703)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3703
REGS3_k127_7220295_2	1068980.ARVW01000001_gene4852	3.374e-147	505.0	COG3629@1|root,COG3903@1|root,COG3629@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria,4DXC3@85010|Pseudonocardiales	201174|Actinobacteria	K	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22,BTAD,NB-ARC,TPR_12,Trans_reg_C
REGS3_k127_7220295_14	1038860.AXAP01000053_gene7258	0.0001298	49.0	COG0457@1|root,COG0457@2|Bacteria,1N01S@1224|Proteobacteria,2TSR4@28211|Alphaproteobacteria,3JTG9@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_7220295_10	298655.KI912266_gene5120	1.602e-26	118.0	28ME7@1|root,2ZARX@2|Bacteria,2GTJG@201174|Actinobacteria	201174|Actinobacteria	S	Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
REGS3_k127_7220295_1	105420.BBPO01000005_gene2762	1.191e-165	555.0	COG2409@1|root,COG2409@2|Bacteria,2GJ5A@201174|Actinobacteria,2NI1Z@228398|Streptacidiphilus	201174|Actinobacteria	S	MMPL family	-	-	-	ko:K06994	-	-	-	-	ko00000	-	-	-	MMPL
REGS3_k127_7220295_5	446470.Snas_4946	3.504e-76	263.0	COG2197@1|root,COG2197@2|Bacteria,2GJ46@201174|Actinobacteria,4EXYW@85014|Glycomycetales	201174|Actinobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
REGS3_k127_7220295_3	1380370.JIBA01000017_gene2939	3.652e-108	363.0	COG4585@1|root,COG4585@2|Bacteria,2GJEG@201174|Actinobacteria,4FH4A@85021|Intrasporangiaceae	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
REGS3_k127_7220295_4	1172188.KB911824_gene3380	4.462e-92	314.0	COG1131@1|root,COG1131@2|Bacteria,2H3JQ@201174|Actinobacteria,4FINS@85021|Intrasporangiaceae	201174|Actinobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
REGS3_k127_7220295_6	1380370.JIBA01000017_gene2937	9.853e-67	236.0	2FD8H@1|root,345AH@2|Bacteria,2GS0J@201174|Actinobacteria,4FIXE@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_7220295_0	1229780.BN381_290161	5.034e-183	581.0	COG3177@1|root,COG3177@2|Bacteria,2GN3K@201174|Actinobacteria,3UXE6@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	Fic/DOC family	-	-	-	-	-	-	-	-	-	-	-	-	Fic,Fic_N
REGS3_k127_7220295_9	710696.Intca_1861	3.105e-42	161.0	2E6U3@1|root,331DV@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	RsbRD_N
REGS3_k127_7220295_13	284031.JNXD01000037_gene6290	5.742e-06	55.0	COG1366@1|root,COG1366@2|Bacteria,2IQCB@201174|Actinobacteria	201174|Actinobacteria	T	Belongs to the anti-sigma-factor antagonist family	-	-	-	-	-	-	-	-	-	-	-	-	STAS,STAS_2
REGS3_k127_7220295_7	469383.Cwoe_3147	1.108e-49	188.0	COG2203@1|root,COG2203@2|Bacteria,2IQAM@201174|Actinobacteria	201174|Actinobacteria	T	ANTAR	-	-	-	-	-	-	-	-	-	-	-	-	ANTAR,GAF_2
REGS3_k127_7220295_12	1289387.AUKW01000002_gene51	9.965e-07	56.0	COG2203@1|root,COG2203@2|Bacteria,2GQ2V@201174|Actinobacteria	201174|Actinobacteria	T	ANTAR domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ANTAR,GAF_2
REGS3_k127_7222335_1	1380393.JHVP01000005_gene3651	1.263e-170	555.0	COG0659@1|root,COG0659@2|Bacteria,2GJCB@201174|Actinobacteria,4ERPC@85013|Frankiales	201174|Actinobacteria	P	Sulfate permease family	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
REGS3_k127_7222335_6	710687.KI912270_gene1401	1.442e-72	267.0	COG0577@1|root,COG0577@2|Bacteria,2HNFQ@201174|Actinobacteria,234N9@1762|Mycobacteriaceae	201174|Actinobacteria	V	FtsX-like permease family	-	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0009405,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044419,GO:0044425,GO:0044459,GO:0044464,GO:0051704,GO:0071944	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
REGS3_k127_7222335_4	547163.BN979_01117	3.444e-104	353.0	COG1136@1|root,COG1136@2|Bacteria,2GJN6@201174|Actinobacteria,233TP@1762|Mycobacteriaceae	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,cNMP_binding
REGS3_k127_7222335_3	743718.Isova_0817	1.47e-108	380.0	COG0507@1|root,COG0507@2|Bacteria,2GIX1@201174|Actinobacteria,4F56S@85017|Promicromonosporaceae	201174|Actinobacteria	L	Viral (Superfamily 1) RNA helicase	recD	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	3.1.11.5	ko:K03581	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_30,UvrD_C_2
REGS3_k127_7222335_0	593907.Celgi_2265	7.483e-177	599.0	COG1074@1|root,COG1074@2|Bacteria,2GNKH@201174|Actinobacteria	201174|Actinobacteria	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA	recB	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	3.1.11.5	ko:K03582	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
REGS3_k127_7222335_2	196162.Noca_0251	2.386e-162	553.0	COG1330@1|root,COG1330@2|Bacteria,2GNVB@201174|Actinobacteria,4DNIF@85009|Propionibacteriales	201174|Actinobacteria	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity	recC	GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0004518,GO:0004519,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030312,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360	3.1.11.5	ko:K03583	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_V_gamma
REGS3_k127_7222335_5	1169143.KB911044_gene3474	6.663e-95	319.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2VHQD@28216|Betaproteobacteria,1K09N@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Aldehyde dehydrogenase	betB	-	1.2.1.3,1.2.1.8	ko:K00128,ko:K00130	ko00010,ko00053,ko00071,ko00260,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00260,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135,M00555	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02565,R02566,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
REGS3_k127_7277782_9	110319.CF8_3686	1.587e-20	92.0	COG3795@1|root,COG3795@2|Bacteria,2IKRD@201174|Actinobacteria,4DR82@85009|Propionibacteriales	201174|Actinobacteria	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
REGS3_k127_7277782_11	58123.JOFJ01000020_gene3743	0.0005123	43.0	COG4941@1|root,COG4941@2|Bacteria,2GJ36@201174|Actinobacteria,4EMFS@85012|Streptosporangiales	201174|Actinobacteria	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
REGS3_k127_7277782_7	1380390.JIAT01000010_gene4052	9.373e-37	146.0	COG3932@1|root,COG3932@2|Bacteria,2H701@201174|Actinobacteria,4CRAU@84995|Rubrobacteria	84995|Rubrobacteria	S	Exopolysaccharide synthesis, ExoD	-	-	-	-	-	-	-	-	-	-	-	-	ExoD
REGS3_k127_7277782_0	235985.BBPN01000068_gene7287	9.125e-234	739.0	COG2015@1|root,COG2015@2|Bacteria,2GK38@201174|Actinobacteria,2NED1@228398|Streptacidiphilus	201174|Actinobacteria	Q	Alkyl sulfatase dimerisation	-	-	-	-	-	-	-	-	-	-	-	-	Alkyl_sulf_C,Alkyl_sulf_dimr,Lactamase_B
REGS3_k127_7277782_2	1313172.YM304_41590	1.967e-70	246.0	COG0218@1|root,COG0218@2|Bacteria	2|Bacteria	D	Necessary for normal cell division and for the maintenance of normal septation	engB	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0017076,GO:0019001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K03978	-	-	-	-	ko00000,ko03036	-	-	-	MMR_HSR1
REGS3_k127_7277782_6	1254432.SCE1572_18515	4.331e-50	184.0	COG0346@1|root,COG0346@2|Bacteria,1R6IN@1224|Proteobacteria	1224|Proteobacteria	E	COG0346 Lactoylglutathione lyase and related lyases	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
REGS3_k127_7277782_3	710686.Mycsm_02069	1.873e-64	229.0	COG2030@1|root,COG2030@2|Bacteria,2GN7T@201174|Actinobacteria,235VM@1762|Mycobacteriaceae	201174|Actinobacteria	I	N-terminal half of MaoC dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydrat_N
REGS3_k127_7277782_4	1408452.JAGZ01000001_gene3749	2.071e-59	211.0	COG1545@1|root,COG1545@2|Bacteria,2GM2A@201174|Actinobacteria,239A1@1762|Mycobacteriaceae	201174|Actinobacteria	S	nucleic-acid-binding protein containing a Zn-ribbon	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
REGS3_k127_7277782_5	710686.Mycsm_02066	4.794e-52	188.0	COG2030@1|root,COG2030@2|Bacteria,2IHT0@201174|Actinobacteria,2392X@1762|Mycobacteriaceae	201174|Actinobacteria	I	MaoC like domain	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
REGS3_k127_7277782_1	1078020.KEK_22289	4.033e-199	626.0	COG0183@1|root,COG0183@2|Bacteria,2GKFR@201174|Actinobacteria,232S0@1762|Mycobacteriaceae	201174|Actinobacteria	I	lipid-transfer protein	-	-	-	-	-	-	-	-	-	-	-	-	Thiolase_N
REGS3_k127_7277782_8	1206744.BAGL01000042_gene1143	9.9e-23	99.0	COG3214@1|root,COG3214@2|Bacteria,2GK0T@201174|Actinobacteria,4FVI4@85025|Nocardiaceae	201174|Actinobacteria	S	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_42
REGS3_k127_7456927_2	709986.Deima_2124	5.9e-24	104.0	COG5001@1|root,COG5001@2|Bacteria	2|Bacteria	T	cyclic-guanylate-specific phosphodiesterase activity	-	-	2.7.7.65	ko:K21023	ko02025,map02025	-	-	-	ko00000,ko00001,ko01000	-	-	-	EAL,GGDEF
REGS3_k127_7456927_1	1211815.CBYP010000073_gene3691	1.674e-29	132.0	COG5001@1|root,COG5001@2|Bacteria,2GIZF@201174|Actinobacteria,4ESAW@85013|Frankiales	201174|Actinobacteria	T	PAS fold domain protein	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_4
REGS3_k127_7456927_0	1049564.TevJSym_bi00080	1.253e-115	398.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1J56I@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	T	(GGDEF) domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3365,EAL,GGDEF,PAS_3,PAS_9,Response_reg
REGS3_k127_74601_3	1122611.KB903996_gene7507	4.332e-137	454.0	COG2041@1|root,COG2041@2|Bacteria,2GMG2@201174|Actinobacteria,4EFP2@85012|Streptosporangiales	201174|Actinobacteria	S	Oxidoreductase molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_molyb
REGS3_k127_74601_4	1313172.YM304_37370	4.247e-126	418.0	COG1570@1|root,COG1570@2|Bacteria,2GJAS@201174|Actinobacteria,4CNA1@84992|Acidimicrobiia	84992|Acidimicrobiia	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
REGS3_k127_74601_8	1229780.BN381_70072	1.968e-11	74.0	COG1722@1|root,COG1722@2|Bacteria,2HD2Z@201174|Actinobacteria	201174|Actinobacteria	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	-	-	3.1.11.6	ko:K03602	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_S
REGS3_k127_74601_2	1313172.YM304_37400	6.729e-138	446.0	COG0142@1|root,COG0142@2|Bacteria,2GJEK@201174|Actinobacteria,4CMXY@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Polyprenyl synthetase	-	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13787	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
REGS3_k127_74601_6	1313172.YM304_38760	3.954e-69	245.0	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6,Hydrolase_4,NAD_binding_4
REGS3_k127_74601_1	1313172.YM304_38750	2.465e-140	453.0	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
REGS3_k127_74601_10	324602.Caur_1957	7.363e-07	61.0	COG1388@1|root,COG1388@2|Bacteria,2G99N@200795|Chloroflexi,375XT@32061|Chloroflexia	32061|Chloroflexia	M	PFAM Peptidoglycan-binding LysM	-	-	-	-	-	-	-	-	-	-	-	-	LysM
REGS3_k127_74601_5	1313172.YM304_38730	4.154e-118	383.0	2EWQK@1|root,33Q2D@2|Bacteria,2IJ4T@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_74601_9	1396418.BATQ01000136_gene3698	7.269e-09	64.0	COG2453@1|root,COG2453@2|Bacteria	2|Bacteria	T	phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	DSPc,Y_phosphatase
REGS3_k127_74601_0	1313172.YM304_38140	0.0	1009.0	COG1884@1|root,COG2185@1|root,COG1884@2|Bacteria,COG2185@2|Bacteria,2GM65@201174|Actinobacteria,4CMVR@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Methylmalonyl-CoA mutase	-	-	5.4.99.63	ko:K14447	ko00630,ko01120,ko01200,map00630,map01120,map01200	M00373	R09292	RC02835	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,MM_CoA_mutase
REGS3_k127_748227_3	391587.KAOT1_19337	2.045e-09	70.0	COG1807@1|root,COG1807@2|Bacteria,4P0P4@976|Bacteroidetes,1I8CJ@117743|Flavobacteriia	976|Bacteroidetes	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
REGS3_k127_748227_0	1206741.BAFX01000181_gene6578	7.827e-119	394.0	COG1804@1|root,COG1804@2|Bacteria,2GIU7@201174|Actinobacteria,4FW6T@85025|Nocardiaceae	201174|Actinobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
REGS3_k127_748227_1	1123073.KB899241_gene1989	1.345e-14	85.0	COG3794@1|root,COG3794@2|Bacteria,1QS6V@1224|Proteobacteria,1RVIU@1236|Gammaproteobacteria,1XBHU@135614|Xanthomonadales	135614|Xanthomonadales	C	Cupredoxin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1
REGS3_k127_748227_2	1333998.M2A_2748	1.087e-10	73.0	COG3794@1|root,COG3794@2|Bacteria,1RI9G@1224|Proteobacteria,2U7KA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cupredoxin_1
REGS3_k127_7522235_19	1313172.YM304_08940	3.417e-25	107.0	COG1214@1|root,COG1214@2|Bacteria	2|Bacteria	O	tRNA threonylcarbamoyladenosine modification	yeaZ	GO:0002949,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070011,GO:0070525,GO:0071704,GO:0090304,GO:0140096,GO:1901360,GO:1901564	2.3.1.234	ko:K01409,ko:K14742	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
REGS3_k127_7522235_16	1313172.YM304_08930	2.911e-46	174.0	COG0802@1|root,COG0802@2|Bacteria,2IKV2@201174|Actinobacteria,4CNEU@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Threonylcarbamoyl adenosine biosynthesis protein TsaE	-	-	-	ko:K06925	-	-	-	-	ko00000,ko03016	-	-	-	TsaE
REGS3_k127_7522235_4	1313172.YM304_08920	5.075e-125	411.0	COG0787@1|root,COG0787@2|Bacteria,2GM2Y@201174|Actinobacteria,4CN11@84992|Acidimicrobiia	84992|Acidimicrobiia	M	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
REGS3_k127_7522235_3	1313172.YM304_08910	4.886e-134	442.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,2GJHB@201174|Actinobacteria,4CMZ5@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
REGS3_k127_7522235_17	1313172.YM304_08850	4.454e-46	168.0	COG0736@1|root,COG0736@2|Bacteria,2HGFC@201174|Actinobacteria,4CND0@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein	acpS	-	2.7.8.7	ko:K00997	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
REGS3_k127_7522235_0	1313172.YM304_08840	0.0	1357.0	COG0449@1|root,COG0449@2|Bacteria,2GKH0@201174|Actinobacteria,4CN8H@84992|Acidimicrobiia	84992|Acidimicrobiia	M	Glutamine amidotransferase domain	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
REGS3_k127_7522235_5	1313172.YM304_08820	3.396e-124	412.0	COG1109@1|root,COG1109@2|Bacteria,2GN87@201174|Actinobacteria,4CMWY@84992|Acidimicrobiia	84992|Acidimicrobiia	G	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III	glmM	-	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
REGS3_k127_7522235_14	1313172.YM304_08810	1.171e-50	182.0	COG0103@1|root,COG0103@2|Bacteria,2GNDY@201174|Actinobacteria,4CN72@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Ribosomal protein S9/S16	rpsI	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
REGS3_k127_7522235_10	1313172.YM304_08800	2.831e-65	230.0	COG0102@1|root,COG0102@2|Bacteria,2IFG1@201174|Actinobacteria,4CN26@84992|Acidimicrobiia	84992|Acidimicrobiia	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	-	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
REGS3_k127_7522235_9	1313172.YM304_08770	2.403e-72	255.0	COG0101@1|root,COG0101@2|Bacteria,2GJ6C@201174|Actinobacteria,4CNBD@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	-	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
REGS3_k127_7522235_13	1313172.YM304_08760	1.331e-51	184.0	COG0203@1|root,COG0203@2|Bacteria,2IHV2@201174|Actinobacteria,4CN4I@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Ribosomal protein L17	rplQ	-	-	ko:K02879	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L17
REGS3_k127_7522235_2	1313172.YM304_08750	4.43e-159	505.0	COG0202@1|root,COG0202@2|Bacteria,2GJJ5@201174|Actinobacteria,4CMSV@84992|Acidimicrobiia	84992|Acidimicrobiia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	-	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
REGS3_k127_7522235_6	1313172.YM304_08740	1.668e-107	350.0	COG0522@1|root,COG0522@2|Bacteria,2GIRX@201174|Actinobacteria,4CN4S@84992|Acidimicrobiia	84992|Acidimicrobiia	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	-	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
REGS3_k127_7522235_11	1313172.YM304_08730	2.69e-58	207.0	COG0100@1|root,COG0100@2|Bacteria,2IFFC@201174|Actinobacteria,4CN7A@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome	rpsK	-	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
REGS3_k127_7522235_15	717605.Theco_0307	1.273e-50	182.0	COG0099@1|root,COG0099@2|Bacteria,1V3JH@1239|Firmicutes,4HGX6@91061|Bacilli,26XFY@186822|Paenibacillaceae	91061|Bacilli	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
REGS3_k127_7522235_20	1033730.CAHG01000003_gene156	3.475e-16	78.0	COG0257@1|root,COG0257@2|Bacteria,2GWMH@201174|Actinobacteria,4DSPP@85009|Propionibacteriales	201174|Actinobacteria	J	Belongs to the bacterial ribosomal protein bL36 family	rpmJ	-	-	ko:K02919	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L36
REGS3_k127_7522235_18	525909.Afer_0421	8.057e-35	134.0	COG0361@1|root,COG0361@2|Bacteria,2IQ4B@201174|Actinobacteria,4CNX6@84992|Acidimicrobiia	84992|Acidimicrobiia	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	-	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
REGS3_k127_7522235_8	1179773.BN6_42810	7.102e-75	260.0	COG0024@1|root,COG0024@2|Bacteria,2GKKB@201174|Actinobacteria,4DY9S@85010|Pseudonocardiales	201174|Actinobacteria	E	methionine	-	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
REGS3_k127_7522235_7	1313172.YM304_08460	3.872e-102	336.0	COG0563@1|root,COG0563@2|Bacteria,2GJ7T@201174|Actinobacteria,4CMZ1@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK,ADK_lid
REGS3_k127_7522235_1	1313172.YM304_08450	7.345e-194	613.0	COG0201@1|root,COG0201@2|Bacteria,2GJ26@201174|Actinobacteria,4CMWZ@84992|Acidimicrobiia	84992|Acidimicrobiia	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
REGS3_k127_7522235_12	1313172.YM304_08440	1.073e-53	194.0	COG0200@1|root,COG0200@2|Bacteria,2II6M@201174|Actinobacteria,4CN1G@84992|Acidimicrobiia	84992|Acidimicrobiia	J	binds to the 23S rRNA	rplO	-	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
REGS3_k127_7522235_21	1313172.YM304_08430	2.985e-09	57.0	COG1841@1|root,COG1841@2|Bacteria,2HGDQ@201174|Actinobacteria,4CNC3@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Ribosomal protein L30p/L7e	rpmD	-	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
REGS3_k127_7552643_1	1313172.YM304_37190	2.396e-141	457.0	COG1793@1|root,COG1793@2|Bacteria,2I2EA@201174|Actinobacteria	201174|Actinobacteria	L	dna ligase	ligC	GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016874,GO:0016886,GO:0022616,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360,GO:1901576	-	-	-	-	-	-	-	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M
REGS3_k127_7552643_2	765420.OSCT_1927	3.371e-35	146.0	COG2968@1|root,COG2968@2|Bacteria,2G6UC@200795|Chloroflexi,377CQ@32061|Chloroflexia	32061|Chloroflexia	S	Protein of unknown function (DUF541)	-	-	-	ko:K09807	-	-	-	-	ko00000	-	-	-	SIMPL
REGS3_k127_7552643_0	1313172.YM304_37200	3.304e-297	917.0	COG4799@1|root,COG4799@2|Bacteria,2GIRU@201174|Actinobacteria,4CMPB@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Carboxyl transferase domain	-	-	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
REGS3_k127_7602592_8	1313172.YM304_22620	3.098e-38	144.0	COG0131@1|root,COG0131@2|Bacteria,2GKMD@201174|Actinobacteria,4CN2F@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Imidazoleglycerol-phosphate dehydratase	hisB	-	4.2.1.19	ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03457	RC00932	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPD
REGS3_k127_7602592_3	1313172.YM304_22630	1.214e-81	281.0	COG0118@1|root,COG0118@2|Bacteria,2GIYS@201174|Actinobacteria,4CNA3@84992|Acidimicrobiia	84992|Acidimicrobiia	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	-	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
REGS3_k127_7602592_2	913865.DOT_5408	1.176e-109	361.0	COG0107@1|root,COG0107@2|Bacteria,1TP0W@1239|Firmicutes,24900@186801|Clostridia,260VM@186807|Peptococcaceae	186801|Clostridia	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	-	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS05755	His_biosynth
REGS3_k127_7602592_1	999541.bgla_1g28910	5.591e-131	425.0	COG0667@1|root,COG0667@2|Bacteria,1MU1S@1224|Proteobacteria,2VMYU@28216|Betaproteobacteria,1K2AM@119060|Burkholderiaceae	28216|Betaproteobacteria	C	aldo keto reductase	-	-	-	ko:K19265	-	-	-	-	ko00000,ko01000	-	-	-	Aldo_ket_red
REGS3_k127_7602592_7	1313172.YM304_22680	2.172e-39	157.0	COG2945@1|root,COG2945@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K07018	-	-	-	-	ko00000	-	-	-	Hydrolase_4
REGS3_k127_7602592_6	1313172.YM304_22690	2.706e-42	163.0	COG0234@1|root,COG0234@2|Bacteria,2IHRC@201174|Actinobacteria,4CN9G@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	-	-	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
REGS3_k127_7602592_5	1313172.YM304_22700	3.442e-45	167.0	COG0139@1|root,COG0139@2|Bacteria,2IKKU@201174|Actinobacteria,4CN95@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP	hisI	-	3.5.4.19	ko:K01496	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04037	RC01055	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-CH
REGS3_k127_7602592_0	1313172.YM304_22710	5.826e-253	787.0	COG0147@1|root,COG0147@2|Bacteria,2GKJT@201174|Actinobacteria,4CMW2@84992|Acidimicrobiia	84992|Acidimicrobiia	EH	Anthranilate synthase component I, N terminal region	trpE	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
REGS3_k127_7602592_4	1313172.YM304_22730	3.021e-49	186.0	COG0354@1|root,COG0354@2|Bacteria,2HGHB@201174|Actinobacteria,4CNEP@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Aminomethyltransferase folate-binding domain	-	-	-	ko:K06980	-	-	-	-	ko00000,ko03016	-	-	-	GCV_T
REGS3_k127_7602592_9	1313172.YM304_11290	1.255e-26	110.0	COG1403@1|root,COG1403@2|Bacteria,2ICGQ@201174|Actinobacteria	201174|Actinobacteria	V	Domain of unknown function (DUF222)	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
REGS3_k127_760367_3	1125971.ASJB01000015_gene5659	2.361e-20	95.0	COG2223@1|root,COG2223@2|Bacteria,2I5DV@201174|Actinobacteria,4EDW9@85010|Pseudonocardiales	201174|Actinobacteria	P	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
REGS3_k127_760367_1	685727.REQ_42280	7.216e-147	482.0	COG0318@1|root,COG0318@2|Bacteria,2I8TA@201174|Actinobacteria,4G01M@85025|Nocardiaceae	201174|Actinobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	-	ko:K12507	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
REGS3_k127_760367_2	35754.JNYJ01000003_gene6551	5.429e-77	265.0	COG0235@1|root,COG0235@2|Bacteria,2GJ8W@201174|Actinobacteria,4D9VJ@85008|Micromonosporales	201174|Actinobacteria	G	Class II Aldolase and Adducin N-terminal domain	araD	-	-	-	-	-	-	-	-	-	-	-	Aldolase_II
REGS3_k127_760367_0	931627.MycrhDRAFT_1541	2.699e-197	627.0	COG2159@1|root,COG2159@2|Bacteria,2GKG2@201174|Actinobacteria,235XV@1762|Mycobacteriaceae	201174|Actinobacteria	S	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
REGS3_k127_760367_4	749927.AMED_8841	5.725e-16	87.0	COG2272@1|root,COG2272@2|Bacteria,2GJCN@201174|Actinobacteria,4E1K3@85010|Pseudonocardiales	201174|Actinobacteria	I	Carboxylesterase family	-	-	-	ko:K03929	-	-	-	-	ko00000,ko01000	-	CE10	-	COesterase
REGS3_k127_7752514_5	350054.Mflv_1790	2.005e-41	159.0	COG1028@1|root,COG1028@2|Bacteria,2GJ1F@201174|Actinobacteria,233YP@1762|Mycobacteriaceae	201174|Actinobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
REGS3_k127_7752514_1	1313172.YM304_03800	4.753e-105	356.0	COG0596@1|root,COG0596@2|Bacteria,2GMMB@201174|Actinobacteria	201174|Actinobacteria	M	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
REGS3_k127_7752514_2	1313172.YM304_03780	5.923e-83	284.0	COG4760@1|root,COG4760@2|Bacteria,2GNCK@201174|Actinobacteria	201174|Actinobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	BaxI_1
REGS3_k127_7752514_4	1313172.YM304_03770	1.147e-42	158.0	COG1359@1|root,COG1359@2|Bacteria	2|Bacteria	S	Antibiotic biosynthesis monooxygenase	yphI	-	1.14.99.57	ko:K06996,ko:K21481	-	-	-	-	ko00000,ko01000	-	-	-	ABM
REGS3_k127_7752514_0	1313172.YM304_03760	1.084e-176	556.0	COG0568@1|root,COG0568@2|Bacteria,2GK3Z@201174|Actinobacteria,4CMST@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
REGS3_k127_7752514_3	318424.EU78_04750	6.863e-75	257.0	COG0596@1|root,COG0596@2|Bacteria,2GY3A@201174|Actinobacteria,236DE@1762|Mycobacteriaceae	201174|Actinobacteria	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
REGS3_k127_7786667_2	1313172.YM304_24620	1.444e-95	324.0	COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4CNI7@84992|Acidimicrobiia	84992|Acidimicrobiia	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
REGS3_k127_7786667_4	710686.Mycsm_04994	1e-48	179.0	COG2259@1|root,COG2259@2|Bacteria,2IQ5C@201174|Actinobacteria,235J5@1762|Mycobacteriaceae	201174|Actinobacteria	S	DoxX family	-	-	-	ko:K15977	-	-	-	-	ko00000	-	-	-	DoxX
REGS3_k127_7786667_3	1313172.YM304_24600	1.391e-90	302.0	COG0110@1|root,COG0110@2|Bacteria,2GNUB@201174|Actinobacteria	201174|Actinobacteria	M	Acetyltransferase (isoleucine patch	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	2.3.1.79	ko:K00661	-	-	-	-	ko00000,ko01000	-	-	-	Hexapep,Hexapep_2
REGS3_k127_7786667_1	1280954.HPO_10487	1.173e-100	335.0	COG1024@1|root,COG1024@2|Bacteria,1P5FE@1224|Proteobacteria,2U1TI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
REGS3_k127_7786667_0	1313172.YM304_24590	1.912e-144	476.0	COG2272@1|root,COG2272@2|Bacteria,2GJCN@201174|Actinobacteria,4CNSB@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Carboxylesterase family	-	-	-	ko:K03929	-	-	-	-	ko00000,ko01000	-	CE10	-	COesterase
REGS3_k127_7786667_5	1121033.AUCF01000008_gene5742	6.613e-38	152.0	COG1183@1|root,COG1183@2|Bacteria,1NGCJ@1224|Proteobacteria,2TS1K@28211|Alphaproteobacteria,2JSRI@204441|Rhodospirillales	204441|Rhodospirillales	I	Condenses choline with CDP-diglyceride to produce phosphatidylcholine and CMP	-	-	2.7.8.24	ko:K01004	ko00564,ko01110,map00564,map01110	-	R05794	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	-
REGS3_k127_7821403_12	500153.JOEK01000003_gene898	1.382e-68	246.0	COG0510@1|root,COG0510@2|Bacteria,2GMFN@201174|Actinobacteria	201174|Actinobacteria	M	Aminoglycoside phosphotransferase	-	-	-	-	-	-	-	-	-	-	-	-	APH
REGS3_k127_7821403_14	1288079.AUKN01000003_gene3843	2.224e-08	65.0	COG0491@1|root,COG0491@2|Bacteria,2GMSA@201174|Actinobacteria	201174|Actinobacteria	S	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
REGS3_k127_7821403_4	926550.CLDAP_17970	2.021e-120	401.0	COG3669@1|root,COG3669@2|Bacteria,2G801@200795|Chloroflexi	200795|Chloroflexi	G	PFAM glycoside hydrolase family 29 (alpha-L-fucosidase)	-	-	3.2.1.51	ko:K01206	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04147	-	GH29	-	Alpha_L_fucos
REGS3_k127_7821403_1	1380394.JADL01000004_gene6008	5.395e-175	567.0	COG0824@1|root,COG1250@1|root,COG0824@2|Bacteria,COG1250@2|Bacteria,1MV8M@1224|Proteobacteria,2TRAW@28211|Alphaproteobacteria,2JQTT@204441|Rhodospirillales	204441|Rhodospirillales	I	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	3HCDH,3HCDH_N,4HBT_2
REGS3_k127_7821403_3	1380394.JADL01000004_gene6007	6.284e-137	442.0	COG3246@1|root,COG3246@2|Bacteria,1MZTP@1224|Proteobacteria,2TQKN@28211|Alphaproteobacteria,2JQGU@204441|Rhodospirillales	204441|Rhodospirillales	S	beta-keto acid cleavage enzyme	-	-	-	-	-	-	-	-	-	-	-	-	BKACE
REGS3_k127_7821403_5	216591.BCAM2290	2.649e-109	368.0	COG2175@1|root,COG2175@2|Bacteria,1MX7P@1224|Proteobacteria,2WB4H@28216|Betaproteobacteria,1K56J@119060|Burkholderiaceae	28216|Betaproteobacteria	Q	Protein of unknown function (DUF971)	-	-	1.14.11.1	ko:K00471	ko00310,map00310	-	R02397	RC00709	ko00000,ko00001,ko01000	-	-	-	DUF971,TauD
REGS3_k127_7821403_11	981369.JQMJ01000001_gene6910	5.812e-82	298.0	COG1409@1|root,COG1409@2|Bacteria,2GK31@201174|Actinobacteria	201174|Actinobacteria	M	ErfK ybiS ycfS ynhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
REGS3_k127_7821403_0	1547437.LL06_19840	1.228e-208	667.0	COG0365@1|root,COG0365@2|Bacteria,1MUX7@1224|Proteobacteria,2TRND@28211|Alphaproteobacteria,43IUF@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	I	COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases	acsA1	-	6.2.1.16	ko:K01907	ko00280,ko00650,map00280,map00650	-	R01357	RC00004,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
REGS3_k127_7821403_7	1121946.AUAX01000032_gene489	7.192e-107	376.0	COG5001@1|root,COG5001@2|Bacteria,2GIZF@201174|Actinobacteria,4DAB5@85008|Micromonosporales	201174|Actinobacteria	T	signal transduction protein containing a membrane domain, an EAL and a GGDEF domain	-	-	2.7.7.65	ko:K21023	ko02025,map02025	-	-	-	ko00000,ko00001,ko01000	-	-	-	EAL,GGDEF
REGS3_k127_7821403_2	1313172.YM304_23940	7.615e-140	453.0	COG1702@1|root,COG1702@2|Bacteria,2GK0W@201174|Actinobacteria,4CMTR@84992|Acidimicrobiia	84992|Acidimicrobiia	T	AAA domain	-	-	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
REGS3_k127_7821403_13	1313172.YM304_23950	6.385e-39	156.0	COG0319@1|root,COG0319@2|Bacteria,2GMUF@201174|Actinobacteria,4CN8G@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA	ybeY	-	-	ko:K07042	-	-	-	-	ko00000,ko03009	-	-	-	UPF0054
REGS3_k127_7821403_8	1121877.JQKF01000022_gene2275	8.224e-93	321.0	COG1253@1|root,COG1253@2|Bacteria,2GIWR@201174|Actinobacteria,4CP58@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Transporter associated domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
REGS3_k127_7821403_6	1313172.YM304_23960	6.318e-107	351.0	COG1028@1|root,COG1028@2|Bacteria,2HF91@201174|Actinobacteria,4CN32@84992|Acidimicrobiia	84992|Acidimicrobiia	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
REGS3_k127_7821403_10	479432.Sros_7428	1.038e-83	295.0	COG0477@1|root,COG2814@2|Bacteria,2GKHG@201174|Actinobacteria,4ENDZ@85012|Streptosporangiales	201174|Actinobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
REGS3_k127_7821403_9	298655.KI912266_gene498	3.258e-86	292.0	COG1028@1|root,COG1028@2|Bacteria,2GNM4@201174|Actinobacteria,4EVVR@85013|Frankiales	201174|Actinobacteria	IQ	KR domain	-	-	1.1.1.100,1.1.1.47	ko:K00034,ko:K00059	ko00030,ko00061,ko00333,ko00780,ko01040,ko01100,ko01120,ko01130,ko01200,ko01212,map00030,map00061,map00333,map00780,map01040,map01100,map01120,map01130,map01200,map01212	M00083,M00572	R01520,R01521,R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00066,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
REGS3_k127_7822646_24	1229780.BN381_290056	2.363e-36	138.0	COG2044@1|root,COG2044@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K06039,ko:K07092	-	-	-	-	ko00000	-	-	-	DrsE
REGS3_k127_7822646_1	1333998.M2A_2255	3.406e-254	792.0	COG2072@1|root,COG2072@2|Bacteria,1MU71@1224|Proteobacteria,2TV2E@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Flavoprotein involved in K transport	MA20_23085	-	-	-	-	-	-	-	-	-	-	-	FMO-like,K_oxygenase,NAD_binding_8,Pyr_redox_2
REGS3_k127_7822646_7	1206726.BAFV01000033_gene2338	1.996e-140	456.0	COG2159@1|root,COG2159@2|Bacteria,2GP2D@201174|Actinobacteria,4FZEY@85025|Nocardiaceae	201174|Actinobacteria	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
REGS3_k127_7822646_27	1463921.JODF01000050_gene5676	2.111e-08	65.0	COG1846@1|root,COG1846@2|Bacteria,2IQNM@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
REGS3_k127_7822646_5	1229780.BN381_130390	5.731e-165	536.0	COG0399@1|root,COG0399@2|Bacteria,2GKD7@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the DegT DnrJ EryC1 family	-	-	1.17.1.1,4.2.1.164	ko:K12452,ko:K13328	ko00520,ko00523,ko01130,map00520,map00523,map01130	M00802	R03391,R03392,R08930	RC00230,RC00704	ko00000,ko00001,ko00002,ko01000	-	-	-	DegT_DnrJ_EryC1
REGS3_k127_7822646_9	1448389.BAVQ01000025_gene1257	7.746e-107	359.0	COG1028@1|root,COG1028@2|Bacteria,2HWDM@201174|Actinobacteria	201174|Actinobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
REGS3_k127_7822646_23	1123322.KB904634_gene2311	1.197e-65	235.0	28MYG@1|root,2ZB5C@2|Bacteria,2H19V@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_7822646_19	1229780.BN381_90043	2.39e-78	269.0	COG3228@1|root,COG3228@2|Bacteria,2H5QX@201174|Actinobacteria	201174|Actinobacteria	S	Glucose-regulated metallo-peptidase M90	-	-	-	ko:K09933	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_M90
REGS3_k127_7822646_0	1184607.AUCHE_05_04270	0.0	1442.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1149@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1149@2|Bacteria,2I995@201174|Actinobacteria	201174|Actinobacteria	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	nifJ	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C
REGS3_k127_7822646_13	926569.ANT_28310	1.078e-99	335.0	COG0167@1|root,COG0167@2|Bacteria,2G5T6@200795|Chloroflexi	200795|Chloroflexi	F	Catalyzes the conversion of dihydroorotate to orotate	-	-	1.3.98.1	ko:K00226	ko00240,ko01100,map00240,map01100	M00051	R01867	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
REGS3_k127_7822646_4	1048339.KB913029_gene661	1.26e-182	586.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4ETYU@85013|Frankiales	201174|Actinobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	6.2.1.3	ko:K00666,ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
REGS3_k127_7822646_25	1035308.AQYY01000001_gene1662	1.146e-25	111.0	COG1733@1|root,COG1733@2|Bacteria	2|Bacteria	K	regulation of RNA biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
REGS3_k127_7822646_18	1035308.AQYY01000001_gene1663	1.528e-79	275.0	COG0265@1|root,COG0265@2|Bacteria	2|Bacteria	O	serine-type endopeptidase activity	hhoA	GO:0003674,GO:0005488,GO:0005515,GO:0042802	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
REGS3_k127_7822646_17	1532557.JL37_28015	7.493e-81	291.0	COG0624@1|root,COG0624@2|Bacteria,1MVBR@1224|Proteobacteria	1224|Proteobacteria	E	Belongs to the peptidase M20A family. ArgE subfamily	argE	-	3.5.1.16	ko:K01438	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R00669,R09107	RC00064,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
REGS3_k127_7822646_11	1168059.KB899087_gene2832	4.68e-106	353.0	COG1028@1|root,COG1028@2|Bacteria,1P9R4@1224|Proteobacteria,2TSIF@28211|Alphaproteobacteria,3F128@335928|Xanthobacteraceae	28211|Alphaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
REGS3_k127_7822646_12	1123320.KB889574_gene5689	1.951e-104	350.0	COG1028@1|root,COG1028@2|Bacteria,2GNVA@201174|Actinobacteria	201174|Actinobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
REGS3_k127_7822646_22	298654.FraEuI1c_2538	6.264e-71	252.0	COG1028@1|root,COG1028@2|Bacteria,2GMG3@201174|Actinobacteria	201174|Actinobacteria	IQ	Short-chain dehydrogenase reductase sdr	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
REGS3_k127_7822646_21	1123320.KB889697_gene9028	2.698e-71	253.0	COG1878@1|root,COG1878@2|Bacteria,2GUSA@201174|Actinobacteria	201174|Actinobacteria	S	cyclase family	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
REGS3_k127_7822646_10	298654.FraEuI1c_1761	2.04e-106	362.0	COG0683@1|root,COG0683@2|Bacteria,2IPWY@201174|Actinobacteria	201174|Actinobacteria	E	Periplasmic binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
REGS3_k127_7822646_8	298655.KI912267_gene7456	1.738e-110	375.0	COG0683@1|root,COG0683@2|Bacteria,2IPWY@201174|Actinobacteria	201174|Actinobacteria	E	Periplasmic binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
REGS3_k127_7822646_3	298654.FraEuI1c_1762	1.603e-186	608.0	COG0559@1|root,COG4177@1|root,COG0559@2|Bacteria,COG4177@2|Bacteria,2GJHR@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997,ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
REGS3_k127_7822646_16	298655.KI912267_gene7454	2.337e-86	293.0	COG0411@1|root,COG0411@2|Bacteria,2H5WA@201174|Actinobacteria	201174|Actinobacteria	E	PFAM ABC transporter related	livG	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
REGS3_k127_7822646_15	685727.REQ_37120	9.577e-89	303.0	COG0410@1|root,COG0410@2|Bacteria,2I8GT@201174|Actinobacteria,4FZ3I@85025|Nocardiaceae	201174|Actinobacteria	E	ABC transporter	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
REGS3_k127_7822646_26	1449069.JMLO01000005_gene1472	6.956e-12	76.0	2DQKP@1|root,337GR@2|Bacteria,2GU0C@201174|Actinobacteria,4G3J4@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_7822646_20	656024.FsymDg_2119	1.555e-72	249.0	COG0605@1|root,COG0605@2|Bacteria,2GJV8@201174|Actinobacteria,4EUBT@85013|Frankiales	201174|Actinobacteria	P	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	sodA	-	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
REGS3_k127_7822646_14	1123320.KB889687_gene924	9.959e-99	329.0	COG1024@1|root,COG1024@2|Bacteria,2GNTG@201174|Actinobacteria	201174|Actinobacteria	I	Enoyl-CoA hydratase	echA8_6	-	-	-	-	-	-	-	-	-	-	-	ECH_1
REGS3_k127_7822646_2	357808.RoseRS_3480	2.88e-227	734.0	COG1472@1|root,COG1472@2|Bacteria,2G639@200795|Chloroflexi,374XN@32061|Chloroflexia	32061|Chloroflexia	G	Belongs to the glycosyl hydrolase 3 family	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C,PA14
REGS3_k127_7822646_6	371731.Rsw2DRAFT_1825	3.263e-148	482.0	COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,2TRBN@28211|Alphaproteobacteria,1FCC7@1060|Rhodobacter	28211|Alphaproteobacteria	EQ	Hydantoinase/oxoprolinase N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	Hydant_A_N,Hydantoinase_A
REGS3_k127_783807_14	208444.JNYY01000001_gene5350	1.066e-59	209.0	COG3383@1|root,COG3383@2|Bacteria,2HC9H@201174|Actinobacteria,4DZUH@85010|Pseudonocardiales	201174|Actinobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	fdnG	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdopterin,Molydop_binding
REGS3_k127_783807_2	665577.JH993789_gene6977	6.605e-231	737.0	COG1894@1|root,COG1894@2|Bacteria,2GMMC@201174|Actinobacteria	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	-	-	1.17.1.9,1.6.5.3	ko:K00122,ko:K00335	ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200	M00144	R00519,R11945	RC00061,RC02796	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB
REGS3_k127_783807_5	28444.JODQ01000008_gene965	4.673e-144	471.0	COG3383@1|root,COG3383@2|Bacteria,2GKBP@201174|Actinobacteria,4EI2K@85012|Streptosporangiales	201174|Actinobacteria	C	2Fe-2S iron-sulfur cluster binding domain	-	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,Fer4_6,Fer4_7,Molybdop_Fe4S4,NADH-G_4Fe-4S_3
REGS3_k127_783807_9	710111.FraQA3DRAFT_3122	5.388e-93	320.0	COG0285@1|root,COG0285@2|Bacteria,2GJP2@201174|Actinobacteria,4ERQF@85013|Frankiales	201174|Actinobacteria	H	Mur ligase, middle domain protein	folC	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M
REGS3_k127_783807_1	105422.BBPM01000018_gene2434	7.36e-293	914.0	COG2303@1|root,COG2303@2|Bacteria,2GJAU@201174|Actinobacteria,2NGX8@228398|Streptacidiphilus	201174|Actinobacteria	E	GMC oxidoreductase	betA	-	1.1.99.1	ko:K00108	ko00260,ko01100,map00260,map01100	M00555	R01025	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	GMC_oxred_C,GMC_oxred_N
REGS3_k127_783807_12	1469245.JFBG01000010_gene595	9.833e-76	265.0	COG2040@1|root,COG2040@2|Bacteria,1QU2A@1224|Proteobacteria,1RS8M@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	homocysteine	mmuM	-	2.1.1.10	ko:K00547	ko00270,ko01100,ko01110,map00270,map01100,map01110	-	R00650	RC00003,RC00035	ko00000,ko00001,ko01000	-	-	-	S-methyl_trans
REGS3_k127_783807_3	748247.AZKH_p0150	1.387e-218	687.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2VHNV@28216|Betaproteobacteria,2KYF2@206389|Rhodocyclales	28216|Betaproteobacteria	C	Aldehyde dehydrogenase family	betB	-	1.2.1.8	ko:K00130	ko00260,ko01100,map00260,map01100	M00555	R02565,R02566	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
REGS3_k127_783807_8	1125973.JNLC01000011_gene482	5.038e-100	335.0	COG0510@1|root,COG0510@2|Bacteria,1PDP6@1224|Proteobacteria,2VBSW@28211|Alphaproteobacteria,3JXTF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Choline/ethanolamine kinase	-	-	-	-	-	-	-	-	-	-	-	-	APH
REGS3_k127_783807_0	1380391.JIAS01000015_gene369	0.0	1116.0	COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,1MUXJ@1224|Proteobacteria,2TRGS@28211|Alphaproteobacteria,2JREU@204441|Rhodospirillales	28211|Alphaproteobacteria	E	FAD dependent oxidoreductase	-	-	1.5.3.19	ko:K19191	ko00760,ko01120,map00760,map01120	-	R10102	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO,FAO_M,GCV_T,GCV_T_C
REGS3_k127_783807_7	1003195.SCAT_3720	5.702e-134	437.0	COG4175@1|root,COG4175@2|Bacteria,2GJC0@201174|Actinobacteria	201174|Actinobacteria	E	glycine betaine	opuAA	-	3.6.3.32	ko:K02000	ko02010,map02010	M00208	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.12	-	-	ABC_tran,CBS
REGS3_k127_783807_6	1155714.KB891987_gene2547	4.703e-143	481.0	COG4176@1|root,COG4176@2|Bacteria,2GKRF@201174|Actinobacteria	201174|Actinobacteria	E	ABC-type proline glycine betaine transport system permease component	proW	-	-	ko:K02001	ko02010,map02010	M00208	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	BPD_transp_1
REGS3_k127_783807_13	40571.JOEA01000016_gene80	4.596e-65	235.0	COG2113@1|root,COG2113@2|Bacteria,2GP39@201174|Actinobacteria,4E76Y@85010|Pseudonocardiales	201174|Actinobacteria	E	Substrate binding domain of ABC-type glycine betaine transport system	-	-	-	ko:K02002	ko02010,map02010	M00208	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	OpuAC
REGS3_k127_783807_4	1313172.YM304_31120	9.809e-145	468.0	COG1131@1|root,COG1131@2|Bacteria,2GKI7@201174|Actinobacteria,4CP50@84992|Acidimicrobiia	84992|Acidimicrobiia	V	Domain of unknown function (DUF4162)	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
REGS3_k127_783807_11	1313172.YM304_31130	5.607e-85	304.0	COG0842@1|root,COG0842@2|Bacteria,2IPQ3@201174|Actinobacteria	201174|Actinobacteria	U	ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
REGS3_k127_783807_10	1313172.YM304_31140	6.103e-89	303.0	COG0842@1|root,COG0842@2|Bacteria,2ISVA@201174|Actinobacteria	201174|Actinobacteria	V	ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
REGS3_k127_783807_15	1121377.KB906408_gene1081	8.991e-23	99.0	COG2080@1|root,COG2080@2|Bacteria,1WK3N@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	COG2080 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS CutS homologs	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
REGS3_k127_783977_7	867903.ThesuDRAFT_02020	5.782e-24	101.0	COG2080@1|root,COG2080@2|Bacteria,1V6HE@1239|Firmicutes,24HQN@186801|Clostridia	186801|Clostridia	C	aerobic-type carbon monoxide dehydrogenase, small subunit CoxS	hcrC	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
REGS3_k127_783977_2	367299.JOEE01000006_gene808	4.928e-66	234.0	COG1028@1|root,COG1028@2|Bacteria,2GKW9@201174|Actinobacteria,4FIQI@85021|Intrasporangiaceae	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
REGS3_k127_783977_1	1149133.ppKF707_2968	1.781e-78	269.0	COG1028@1|root,COG1028@2|Bacteria,1RFGR@1224|Proteobacteria,1S4S4@1236|Gammaproteobacteria,1YDGN@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
REGS3_k127_783977_8	2074.JNYD01000002_gene5605	4.326e-16	84.0	COG3467@1|root,COG3467@2|Bacteria,2GQIA@201174|Actinobacteria	201174|Actinobacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Pyridox_ox_2
REGS3_k127_783977_3	1068978.AMETH_2900	5.993e-66	231.0	COG1926@1|root,COG1926@2|Bacteria,2GJUU@201174|Actinobacteria,4DZTG@85010|Pseudonocardiales	201174|Actinobacteria	S	Phosphoribosyl transferase domain	-	-	-	ko:K07100	-	-	-	-	ko00000	-	-	-	DLH,Pribosyltran
REGS3_k127_783977_6	452863.Achl_1698	1.253e-29	123.0	COG0071@1|root,COG0071@2|Bacteria,2GQGQ@201174|Actinobacteria,1WBR0@1268|Micrococcaceae	201174|Actinobacteria	O	Belongs to the small heat shock protein (HSP20) family	hspX	GO:0001666,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006457,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0009266,GO:0009267,GO:0009408,GO:0009605,GO:0009607,GO:0009628,GO:0009987,GO:0009991,GO:0010035,GO:0010038,GO:0010039,GO:0016020,GO:0016310,GO:0019538,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0036211,GO:0036293,GO:0036294,GO:0040007,GO:0040008,GO:0042221,GO:0042594,GO:0043170,GO:0043207,GO:0043412,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044121,GO:0044183,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0045926,GO:0046777,GO:0048519,GO:0050789,GO:0050896,GO:0051409,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0065007,GO:0070482,GO:0070887,GO:0071453,GO:0071456,GO:0071496,GO:0071704,GO:0071944,GO:0075136,GO:1901564	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
REGS3_k127_783977_5	208439.AJAP_30635	7.312e-49	191.0	COG0642@1|root,COG0642@2|Bacteria,2GJIV@201174|Actinobacteria,4DXCC@85010|Pseudonocardiales	201174|Actinobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
REGS3_k127_783977_4	710687.KI912270_gene4641	5.506e-59	213.0	COG0745@1|root,COG0745@2|Bacteria,2GP1I@201174|Actinobacteria,23DUG@1762|Mycobacteriaceae	201174|Actinobacteria	T	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
REGS3_k127_783977_0	1385518.N798_05235	0.0	1334.0	COG2132@1|root,COG2132@2|Bacteria,2ICI4@201174|Actinobacteria,4FIU6@85021|Intrasporangiaceae	201174|Actinobacteria	Q	Multicopper oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase_2
REGS3_k127_7854245_13	935866.JAER01000024_gene3108	4.789e-47	177.0	COG0095@1|root,COG0095@2|Bacteria,2GTPJ@201174|Actinobacteria	201174|Actinobacteria	H	Lipoate-protein ligase	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_7854245_8	1313172.YM304_19370	9.766e-71	244.0	COG1403@1|root,COG1403@2|Bacteria,2GN1W@201174|Actinobacteria,4CN5M@84992|Acidimicrobiia	84992|Acidimicrobiia	L	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH_5
REGS3_k127_7854245_0	1313172.YM304_19350	5.461e-214	672.0	COG1960@1|root,COG1960@2|Bacteria,2GM1Q@201174|Actinobacteria,4CNPK@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Acyl-CoA dehydrogenase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
REGS3_k127_7854245_11	1229780.BN381_140020	1.266e-65	234.0	COG1940@1|root,COG1940@2|Bacteria,2GJCQ@201174|Actinobacteria,3UWRA@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	GK	ROK family	-	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
REGS3_k127_7854245_6	1313172.YM304_19330	4.716e-136	441.0	COG0714@1|root,COG0714@2|Bacteria,2GK07@201174|Actinobacteria,4CNN6@84992|Acidimicrobiia	84992|Acidimicrobiia	S	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
REGS3_k127_7854245_12	1313172.YM304_19320	1.811e-54	206.0	COG1721@1|root,COG1721@2|Bacteria,2GIWE@201174|Actinobacteria,4CP1F@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
REGS3_k127_7854245_5	1313172.YM304_19310	3.136e-148	497.0	COG1305@1|root,COG1305@2|Bacteria,2HH1I@201174|Actinobacteria,4CP1R@84992|Acidimicrobiia	2|Bacteria	E	Transglutaminase/protease-like homologues	-	-	-	-	-	-	-	-	-	-	-	-	DUF4129,Transglut_core
REGS3_k127_7854245_18	1313172.YM304_19300	1.032e-09	64.0	2ERJT@1|root,33J59@2|Bacteria,2HGGQ@201174|Actinobacteria,4CNDW@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Protein of unknown function (DUF3040)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3040
REGS3_k127_7854245_4	1313172.YM304_19290	7.494e-154	499.0	COG0389@1|root,COG0389@2|Bacteria,2GKBI@201174|Actinobacteria,4CNR5@84992|Acidimicrobiia	84992|Acidimicrobiia	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	-	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
REGS3_k127_7854245_14	1229780.BN381_140026	5.172e-32	131.0	COG1051@1|root,COG1051@2|Bacteria	2|Bacteria	F	GDP-mannose mannosyl hydrolase activity	MA20_41050	-	3.6.1.67	ko:K08310	ko00790,map00790	M00126	R04638	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NUDIX
REGS3_k127_7854245_9	1313172.YM304_25270	5.168e-70	246.0	COG1216@1|root,COG1216@2|Bacteria,2I2FA@201174|Actinobacteria,4CN03@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Glycosyltransferase like family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
REGS3_k127_7854245_10	1048339.KB913029_gene3864	1.605e-67	243.0	COG0483@1|root,COG0483@2|Bacteria,2GJQE@201174|Actinobacteria,4ESCZ@85013|Frankiales	201174|Actinobacteria	G	Inositol monophosphatase	suhB	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005975,GO:0006020,GO:0006066,GO:0006793,GO:0006796,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008934,GO:0009056,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0019751,GO:0023052,GO:0042578,GO:0043167,GO:0043169,GO:0043647,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0046164,GO:0046174,GO:0046434,GO:0046838,GO:0046855,GO:0046872,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0052745,GO:0052834,GO:0065007,GO:0071545,GO:0071704,GO:1901575,GO:1901615,GO:1901616	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
REGS3_k127_7854245_7	1313172.YM304_19260	1.512e-125	404.0	COG0745@1|root,COG0745@2|Bacteria,2GKFS@201174|Actinobacteria,4CMYH@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Transcriptional regulatory protein, C terminal	-	-	-	ko:K07667	ko02020,ko02024,map02020,map02024	M00454	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
REGS3_k127_7854245_2	1313172.YM304_19250	1.496e-163	530.0	COG0642@1|root,COG2205@2|Bacteria,2GK1J@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
REGS3_k127_7854245_15	1313172.YM304_19240	3.418e-29	124.0	COG5401@1|root,COG5401@2|Bacteria	2|Bacteria	T	PFAM Sporulation and spore germination	-	-	-	-	-	-	-	-	-	-	-	-	Germane
REGS3_k127_7854245_3	1313172.YM304_19230	4.389e-156	500.0	COG0205@1|root,COG0205@2|Bacteria,2GK6W@201174|Actinobacteria	201174|Actinobacteria	G	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	pfp	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
REGS3_k127_7854245_1	1313172.YM304_19210	1.413e-205	648.0	COG0554@1|root,COG0554@2|Bacteria,2GM13@201174|Actinobacteria,4CMTY@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK	-	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
REGS3_k127_7858267_3	485913.Krac_1964	5.499e-52	186.0	COG3945@1|root,COG3945@2|Bacteria,2G96X@200795|Chloroflexi	200795|Chloroflexi	S	TIGRFAM conserved	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red
REGS3_k127_7858267_4	1229780.BN381_130364	3.525e-24	108.0	29ANX@1|root,2ZXNT@2|Bacteria	2|Bacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_4
REGS3_k127_7858267_2	1313172.YM304_19810	2.501e-63	232.0	COG1470@1|root,COG1470@2|Bacteria,2GP8D@201174|Actinobacteria,4CN8S@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Protein of unknown function (DUF3048) C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3048,DUF3048_C
REGS3_k127_7858267_0	1429916.X566_01950	5.487e-180	571.0	COG2141@1|root,COG2141@2|Bacteria,1MX64@1224|Proteobacteria,2TV8M@28211|Alphaproteobacteria,3JTR2@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Luciferase-like monooxygenase	MA20_03405	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
REGS3_k127_7858267_1	459495.SPLC1_S370940	4.292e-96	323.0	COG3391@1|root,COG3409@1|root,COG3391@2|Bacteria,COG3409@2|Bacteria,1G33X@1117|Cyanobacteria,1H9RN@1150|Oscillatoriales	1117|Cyanobacteria	M	Putative peptidoglycan binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_D1,PG_binding_1
REGS3_k127_7874340_1	1907.SGLAU_15210	6.399e-62	224.0	COG0477@1|root,COG0477@2|Bacteria,2GK06@201174|Actinobacteria	201174|Actinobacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
REGS3_k127_7874340_0	1313172.YM304_21060	1.158e-258	803.0	COG0481@1|root,COG0481@2|Bacteria,2GJAB@201174|Actinobacteria,4CMUT@84992|Acidimicrobiia	84992|Acidimicrobiia	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C
REGS3_k127_7883712_5	479432.Sros_3034	3.149e-71	249.0	COG1404@1|root,COG1404@2|Bacteria,2GK3D@201174|Actinobacteria,4EHVJ@85012|Streptosporangiales	201174|Actinobacteria	O	PA domain	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_S8,fn3_5
REGS3_k127_7883712_4	869210.Marky_2033	1.642e-90	325.0	COG1404@1|root,COG1404@2|Bacteria,1WIDU@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	O	peptidase S8 and S53, subtilisin, kexin, sedolisin	-	-	3.4.21.111	ko:K20754	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Inhibitor_I9,Peptidase_S8
REGS3_k127_7883712_6	1313172.YM304_29090	1.621e-58	209.0	2BJWW@1|root,32E9A@2|Bacteria,2HGG7@201174|Actinobacteria,4CNDN@84992|Acidimicrobiia	84992|Acidimicrobiia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_7883712_2	35754.JNYJ01000046_gene3082	4.275e-139	470.0	COG1835@1|root,COG1835@2|Bacteria,2GKI5@201174|Actinobacteria,4DANU@85008|Micromonosporales	201174|Actinobacteria	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
REGS3_k127_7883712_1	1313172.YM304_29120	3.036e-192	612.0	COG0260@1|root,COG0260@2|Bacteria,2GJRB@201174|Actinobacteria,4CMUJ@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
REGS3_k127_7883712_7	67356.KL575594_gene4708	6.065e-54	198.0	COG2353@1|root,COG2353@2|Bacteria,2IM4N@201174|Actinobacteria	201174|Actinobacteria	S	Belongs to the UPF0312 family	-	-	-	-	-	-	-	-	-	-	-	-	YceI
REGS3_k127_7883712_0	1313172.YM304_29200	7.047e-226	716.0	COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4CNI7@84992|Acidimicrobiia	84992|Acidimicrobiia	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
REGS3_k127_7883712_3	134676.ACPL_5560	5.581e-109	366.0	COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4DACA@85008|Micromonosporales	201174|Actinobacteria	V	ABC transporter related	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
REGS3_k127_7886616_0	1313172.YM304_03480	0.0	1225.0	COG0550@1|root,COG1754@1|root,COG0550@2|Bacteria,COG1754@2|Bacteria,2GJU7@201174|Actinobacteria,4CMPI@84992|Acidimicrobiia	84992|Acidimicrobiia	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,Toprim_C_rpt
REGS3_k127_7886616_1	1229780.BN381_130375	1.038e-208	674.0	COG2409@1|root,COG2409@2|Bacteria,2GJ5A@201174|Actinobacteria,3UX5E@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	drug exporters of the RND superfamily	-	-	-	ko:K06994	-	-	-	-	ko00000	-	-	-	CarboxypepD_reg,MMPL
REGS3_k127_7886616_7	543632.JOJL01000004_gene4291	1.404e-23	112.0	2ASCZ@1|root,31HSE@2|Bacteria,2IEI1@201174|Actinobacteria,4DDYC@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_7886616_4	1157638.KB892191_gene4997	4.06e-64	226.0	COG1131@1|root,COG1131@2|Bacteria,2GP3F@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K15555	ko00920,ko02010,map00920,map02010	M00436	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.17.2	-	-	ABC_tran
REGS3_k127_7886616_8	1306406.ASHX01000001_gene3485	4.209e-23	110.0	2FB55@1|root,343BG@2|Bacteria,2IKSK@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_7886616_9	479433.Caci_3349	2.186e-21	100.0	2917I@1|root,2ZNUP@2|Bacteria,2IRP8@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_7886616_2	1123320.KB889710_gene8469	3.072e-182	592.0	COG0559@1|root,COG4177@1|root,COG0559@2|Bacteria,COG4177@2|Bacteria,2GJHR@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997,ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BPD_transp_2
REGS3_k127_7886616_5	479433.Caci_8832	7.836e-59	221.0	COG0411@1|root,COG0411@2|Bacteria,2GMEE@201174|Actinobacteria	201174|Actinobacteria	E	ABC transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BPD_transp_2
REGS3_k127_7886616_6	1123320.KB889710_gene8471	8.649e-53	195.0	COG0410@1|root,COG0410@2|Bacteria,2H96G@201174|Actinobacteria	201174|Actinobacteria	E	ABC transporter	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
REGS3_k127_7886616_3	1463934.JOCF01000004_gene2517	2.669e-146	475.0	COG0683@1|root,COG0683@2|Bacteria,2GMDG@201174|Actinobacteria	201174|Actinobacteria	E	Periplasmic binding protein	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
REGS3_k127_7910879_5	1313172.YM304_22270	2.094e-45	167.0	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	-	-	-	ko:K09017	-	-	-	-	ko00000,ko03000	-	-	-	TetR_N
REGS3_k127_7910879_0	1313172.YM304_22290	1.042e-142	464.0	COG1181@1|root,COG1181@2|Bacteria,2GITC@201174|Actinobacteria,4CN7S@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
REGS3_k127_7910879_1	1313172.YM304_22300	5.32e-131	432.0	COG0770@1|root,COG0770@2|Bacteria,2GK0Y@201174|Actinobacteria,4CN8B@84992|Acidimicrobiia	84992|Acidimicrobiia	M	Mur ligase family, glutamate ligase domain	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase_C,Mur_ligase_M
REGS3_k127_7910879_2	1229780.BN381_80413	7.541e-73	263.0	COG0477@1|root,COG2814@2|Bacteria,2I2EY@201174|Actinobacteria	201174|Actinobacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
REGS3_k127_7910879_6	1380393.JHVP01000002_gene1988	4.916e-44	177.0	COG2200@1|root,COG2200@2|Bacteria,2IG0M@201174|Actinobacteria,4ESEX@85013|Frankiales	201174|Actinobacteria	T	Diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL
REGS3_k127_7910879_7	1095767.CAHD01000100_gene1509	2.858e-26	122.0	COG1191@1|root,COG1191@2|Bacteria,2GKBK@201174|Actinobacteria,4F2J8@85016|Cellulomonadaceae	201174|Actinobacteria	K	Sigma-70 region 3	fliA	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_r2,Sigma70_r3,Sigma70_r4
REGS3_k127_7910879_3	590998.Celf_1828	1.065e-48	188.0	COG1876@1|root,COG1876@2|Bacteria,2IJGR@201174|Actinobacteria,4F2CJ@85016|Cellulomonadaceae	201174|Actinobacteria	M	PFAM peptidase M15B and M15C DD-carboxypeptidase VanY endolysin	vanY	-	-	-	-	-	-	-	-	-	-	-	VanY
REGS3_k127_7910879_10	1121924.ATWH01000002_gene3891	2.409e-10	63.0	COG1551@1|root,COG1551@2|Bacteria,2GRPH@201174|Actinobacteria,4FSZ0@85023|Microbacteriaceae	201174|Actinobacteria	T	Global regulator protein family	csrA	-	-	ko:K03563	ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03019	-	-	-	CsrA
REGS3_k127_7910879_9	1713.JOFV01000028_gene714	1.505e-10	72.0	COG1699@1|root,COG1699@2|Bacteria	2|Bacteria	S	bacterial-type flagellum assembly	fliW	-	-	ko:K13626	-	-	-	-	ko00000,ko02035	-	-	-	FliW
REGS3_k127_7910879_8	1122939.ATUD01000007_gene1918	7.195e-14	82.0	COG1344@1|root,COG1344@2|Bacteria,2IA40@201174|Actinobacteria,4CS69@84995|Rubrobacteria	84995|Rubrobacteria	N	Bacterial flagellin C-terminal helical region	-	-	-	ko:K02397	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_C,Flagellin_N
REGS3_k127_7910879_4	671143.DAMO_1804	4.713e-46	183.0	COG1256@1|root,COG1256@2|Bacteria,2NQ3I@2323|unclassified Bacteria	2|Bacteria	N	Flagellar basal body rod FlgEFG protein C-terminal	flgK	-	-	ko:K02396	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
REGS3_k127_7910879_11	867903.ThesuDRAFT_02288	9.113e-06	59.0	COG2203@1|root,COG3437@1|root,COG2203@2|Bacteria,COG3437@2|Bacteria	2|Bacteria	T	response regulator, receiver	-	-	2.7.13.3	ko:K02030,ko:K02482	-	M00236	-	-	ko00000,ko00002,ko01000,ko01001,ko02000,ko02022	3.A.1.3	-	-	GAF,GAF_2,HATPase_c,HD,HD_5,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
REGS3_k127_7921445_3	298655.KI912266_gene5593	6.908e-67	233.0	COG2141@1|root,COG2141@2|Bacteria,2H0K9@201174|Actinobacteria	201174|Actinobacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
REGS3_k127_7921445_1	1313172.YM304_30870	1.526e-109	361.0	COG1396@1|root,COG1396@2|Bacteria,2GJXM@201174|Actinobacteria	201174|Actinobacteria	K	Helix-turn-helix domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_31
REGS3_k127_7921445_0	196162.Noca_0414	1.067e-245	785.0	COG2936@1|root,COG2936@2|Bacteria,2GK8B@201174|Actinobacteria,4DRUB@85009|Propionibacteriales	201174|Actinobacteria	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
REGS3_k127_7921445_2	1313172.YM304_30850	3.628e-85	286.0	COG0624@1|root,COG0624@2|Bacteria,2GMH2@201174|Actinobacteria	201174|Actinobacteria	E	peptidase	-	-	3.4.17.11	ko:K01295	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
REGS3_k127_7938224_29	501479.ACNW01000050_gene3610	6.729e-34	143.0	COG0697@1|root,COG0697@2|Bacteria,1R46X@1224|Proteobacteria,2TSE9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EG	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
REGS3_k127_7938224_14	1313172.YM304_27710	9.408e-116	383.0	COG0796@1|root,COG0796@2|Bacteria,2GN4I@201174|Actinobacteria,4CN3V@84992|Acidimicrobiia	84992|Acidimicrobiia	M	Provides the (R)-glutamate required for cell wall biosynthesis	murI	-	5.1.1.3	ko:K01776	ko00471,ko01100,map00471,map01100	-	R00260	RC00302	ko00000,ko00001,ko01000,ko01011	-	-	-	Asp_Glu_race
REGS3_k127_7938224_13	1313172.YM304_27700	7.959e-116	379.0	COG0689@1|root,COG0689@2|Bacteria,2GJFI@201174|Actinobacteria,4CMXE@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates	rph	-	2.7.7.56	ko:K00989	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNase_PH,RNase_PH_C
REGS3_k127_7938224_21	1313172.YM304_27690	3.556e-75	257.0	COG0127@1|root,COG0127@2|Bacteria,2GM2B@201174|Actinobacteria,4CNBV@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	-	-	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
REGS3_k127_7938224_12	2074.JNYD01000034_gene6393	8.595e-123	406.0	COG3616@1|root,COG3616@2|Bacteria,2GK0N@201174|Actinobacteria,4E1C7@85010|Pseudonocardiales	201174|Actinobacteria	E	Putative serine dehydratase domain	-	-	-	-	-	-	-	-	-	-	-	-	Ala_racemase_N,D-ser_dehydrat
REGS3_k127_7938224_19	1313172.YM304_16540	9.748e-85	284.0	COG1329@1|root,COG1329@2|Bacteria,2GKSU@201174|Actinobacteria,4CN2D@84992|Acidimicrobiia	84992|Acidimicrobiia	K	CarD-like/TRCF domain	-	-	-	ko:K07736	-	-	-	-	ko00000,ko03000	-	-	-	CarD_CdnL_TRCF
REGS3_k127_7938224_8	309801.trd_A0430	9.214e-139	456.0	COG0174@1|root,COG0174@2|Bacteria,2G5U2@200795|Chloroflexi,27XSZ@189775|Thermomicrobia	2|Bacteria	E	glutamine synthetase	glnA2	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C
REGS3_k127_7938224_15	1229780.BN381_50052	4.541e-106	349.0	COG1028@1|root,COG1028@2|Bacteria,2GJGM@201174|Actinobacteria,3UXS7@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
REGS3_k127_7938224_26	1313172.YM304_16560	2.596e-57	204.0	COG0346@1|root,COG0346@2|Bacteria,2IBM9@201174|Actinobacteria	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase_4
REGS3_k127_7938224_10	1313172.YM304_16570	8.609e-131	423.0	COG2084@1|root,COG2084@2|Bacteria,2GNB0@201174|Actinobacteria,4CNXT@84992|Acidimicrobiia	84992|Acidimicrobiia	I	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_11,NAD_binding_2
REGS3_k127_7938224_17	1313172.YM304_41190	1.57e-98	338.0	COG2124@1|root,COG2124@2|Bacteria,2GJ8V@201174|Actinobacteria	201174|Actinobacteria	Q	cytochrome p450	-	-	-	-	-	-	-	-	-	-	-	-	p450
REGS3_k127_7938224_27	1906.SFRA_03440	1.478e-51	196.0	COG4221@1|root,COG4221@2|Bacteria,2GQNJ@201174|Actinobacteria	201174|Actinobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
REGS3_k127_7938224_6	1117379.BABA_14322	3.565e-149	486.0	COG2141@1|root,COG2141@2|Bacteria,1TRBN@1239|Firmicutes,4HBYT@91061|Bacilli,1ZHB1@1386|Bacillus	91061|Bacilli	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
REGS3_k127_7938224_31	994479.GL877878_gene1554	2.027e-28	124.0	COG1309@1|root,COG1309@2|Bacteria,2IPAX@201174|Actinobacteria,4E51M@85010|Pseudonocardiales	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
REGS3_k127_7938224_9	1229780.BN381_430031	1.845e-133	438.0	COG0161@1|root,COG0161@2|Bacteria,2GKF6@201174|Actinobacteria,3UWEC@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	H	Aminotransferase class-III	bioA2	-	-	-	-	-	-	-	-	-	-	-	Aminotran_3
REGS3_k127_7938224_33	1313172.YM304_29410	4.98e-12	76.0	COG0697@1|root,COG0697@2|Bacteria	2|Bacteria	EG	spore germination	yvbV	-	-	-	-	-	-	-	-	-	-	-	EamA
REGS3_k127_7938224_11	298654.FraEuI1c_1885	1.816e-123	405.0	COG1064@1|root,COG1064@2|Bacteria,2GKNW@201174|Actinobacteria	201174|Actinobacteria	P	alcohol dehydrogenase	-	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
REGS3_k127_7938224_24	37919.EP51_08760	7.827e-68	242.0	COG1028@1|root,COG1028@2|Bacteria,2GM6W@201174|Actinobacteria,4FZ74@85025|Nocardiaceae	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
REGS3_k127_7938224_4	1123320.KB889696_gene9123	2.828e-163	522.0	COG2124@1|root,COG2124@2|Bacteria,2GJ8V@201174|Actinobacteria	201174|Actinobacteria	Q	cytochrome p450	-	-	1.14.13.221	ko:K16046	ko00984,ko01120,map00984,map01120	-	R09859,R11361	RC01216,RC03368	ko00000,ko00001,ko00199,ko01000	-	-	-	p450
REGS3_k127_7938224_28	1229780.BN381_230013	3.3e-44	177.0	29BBV@1|root,2ZCHD@2|Bacteria,2I82W@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	NAGPA
REGS3_k127_7938224_5	1229780.BN381_80234	5.615e-156	510.0	COG1070@1|root,COG1070@2|Bacteria,2GNCR@201174|Actinobacteria,3UXKU@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	G	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	xylB	-	2.7.1.17,2.7.1.215,2.7.1.53	ko:K00854,ko:K00862,ko:K00880	ko00040,ko00053,ko01100,map00040,map00053,map01100	M00014	R01639,R01901,R07127,R11536	RC00002,RC00017,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
REGS3_k127_7938224_0	471852.Tcur_2562	1.13e-203	651.0	COG0076@1|root,COG0076@2|Bacteria,2GKIH@201174|Actinobacteria,4EGGS@85012|Streptosporangiales	201174|Actinobacteria	E	Pyridoxal-dependent decarboxylase conserved domain	-	-	4.1.1.11,4.1.1.25,4.1.2.27	ko:K01634,ko:K18933	ko00350,ko00410,ko00600,ko00680,ko00770,ko01100,ko01110,ko04071,map00350,map00410,map00600,map00680,map00770,map01100,map01110,map04071	M00100	R00489,R00736,R02464,R06516	RC00264,RC00299,RC00721,RC01266	ko00000,ko00001,ko00002,ko01000	-	-	-	Pyridoxal_deC
REGS3_k127_7938224_23	196162.Noca_2682	3.56e-68	241.0	COG0346@1|root,COG0346@2|Bacteria,2HKRN@201174|Actinobacteria,4DPT9@85009|Propionibacteriales	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	ko:K08234	-	-	-	-	ko00000	-	-	-	Glyoxalase
REGS3_k127_7938224_16	58123.JOFJ01000021_gene3979	3.006e-105	351.0	COG1028@1|root,COG1028@2|Bacteria,2GVVR@201174|Actinobacteria,4EPHJ@85012|Streptosporangiales	201174|Actinobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
REGS3_k127_7938224_32	446462.Amir_4481	2.476e-14	85.0	COG0477@1|root,COG2814@2|Bacteria,2IBR1@201174|Actinobacteria	201174|Actinobacteria	EGP	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
REGS3_k127_7938224_1	1211815.CBYP010000075_gene2945	3.239e-180	579.0	COG0513@1|root,COG0513@2|Bacteria,2GIUR@201174|Actinobacteria,4ES4U@85013|Frankiales	201174|Actinobacteria	L	DEAD DEAH box helicase domain protein	rhlE1	-	-	-	-	-	-	-	-	-	-	-	DEAD,Helicase_C
REGS3_k127_7938224_20	1048339.KB913029_gene1211	2.273e-78	267.0	COG4122@1|root,COG4122@2|Bacteria,2GP7A@201174|Actinobacteria,4ETYD@85013|Frankiales	201174|Actinobacteria	S	O-methyltransferase	mdmC	-	2.1.1.104	ko:K00588	ko00360,ko00940,ko00941,ko00945,ko01100,ko01110,map00360,map00940,map00941,map00945,map01100,map01110	M00039,M00350	R01942,R06578	RC00003,RC00392	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_3
REGS3_k127_7938224_22	1229780.BN381_350016	1.044e-68	240.0	28IRH@1|root,2Z8QX@2|Bacteria,2GJW6@201174|Actinobacteria,3UWS4@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_7938224_3	1313172.YM304_17300	8.491e-170	543.0	COG0427@1|root,COG0427@2|Bacteria,2IAMG@201174|Actinobacteria,4CNYP@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Acetyl-CoA hydrolase/transferase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AcetylCoA_hyd_C
REGS3_k127_7938224_2	47839.CCAU010000001_gene3059	2.216e-176	561.0	COG2070@1|root,COG2070@2|Bacteria,2GKGT@201174|Actinobacteria,232ZV@1762|Mycobacteriaceae	201174|Actinobacteria	S	2-nitropropane dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	NMO
REGS3_k127_7938224_25	1123023.JIAI01000011_gene8839	1.072e-66	235.0	2DQY4@1|root,339C4@2|Bacteria,2GP83@201174|Actinobacteria,4EDXZ@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_7938224_7	1122221.JHVI01000023_gene480	8.849e-141	454.0	COG0667@1|root,COG0667@2|Bacteria	2|Bacteria	C	Aldo Keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
REGS3_k127_7938224_18	1122221.JHVI01000023_gene479	2.556e-92	311.0	COG1028@1|root,COG1028@2|Bacteria	1122221.JHVI01000023_gene479|-	IQ	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_7938224_30	1089546.AQUI01000002_gene3937	6.682e-33	149.0	COG1752@1|root,COG1752@2|Bacteria,2IB41@201174|Actinobacteria,409PS@622450|Actinopolysporales	201174|Actinobacteria	S	Protein of unknown function (DUF3376)	-	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF3376,Patatin
REGS3_k127_7989064_1	1160718.SU9_03536	0.0	1041.0	COG0383@1|root,COG0383@2|Bacteria,2GM02@201174|Actinobacteria	201174|Actinobacteria	G	PFAM Glycoside hydrolase, family 38	-	-	3.2.1.24	ko:K01191	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04131	-	GH38	-	Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C
REGS3_k127_7989064_28	1313172.YM304_07310	1.34e-75	261.0	COG0813@1|root,COG0813@2|Bacteria,2GNT6@201174|Actinobacteria	201174|Actinobacteria	F	purine-nucleoside phosphorylase	deoD	-	2.4.2.1,2.4.2.28	ko:K00772,ko:K03784	ko00230,ko00240,ko00270,ko00760,ko01100,ko01110,map00230,map00240,map00270,map00760,map01100,map01110	M00034	R01402,R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244	RC00033,RC00063,RC00122,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
REGS3_k127_7989064_15	1313172.YM304_07320	3.389e-107	354.0	COG0266@1|root,COG0266@2|Bacteria,2GKAM@201174|Actinobacteria	201174|Actinobacteria	L	Belongs to the FPG family	mutM1	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
REGS3_k127_7989064_32	1313172.YM304_07330	3.679e-37	144.0	COG3255@1|root,COG3255@2|Bacteria,2IGUY@201174|Actinobacteria	201174|Actinobacteria	I	SCP-2 sterol transfer family	-	-	-	-	-	-	-	-	-	-	-	-	SCP2
REGS3_k127_7989064_14	1313172.YM304_07350	2.088e-114	378.0	COG0613@1|root,COG0613@2|Bacteria,2GIZ5@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF3097)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3097
REGS3_k127_7989064_36	68260.JOAY01000007_gene29	1.091e-28	128.0	COG3206@1|root,COG3206@2|Bacteria,2GPMH@201174|Actinobacteria	201174|Actinobacteria	M	Domain of unknown function (DUF4349)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4349
REGS3_k127_7989064_30	1463856.JOHY01000076_gene4285	2.758e-68	246.0	COG0586@1|root,COG0586@2|Bacteria,2GKGR@201174|Actinobacteria	201174|Actinobacteria	I	Pfam SNARE associated Golgi protein	yqjA	-	-	ko:K03975	-	-	-	-	ko00000	-	-	-	SNARE_assoc
REGS3_k127_7989064_4	1229780.BN381_130116	1.774e-279	878.0	COG3808@1|root,COG3808@2|Bacteria,2GN8B@201174|Actinobacteria,3UX5K@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
REGS3_k127_7989064_22	1313172.YM304_07470	4.435e-90	306.0	28HIR@1|root,2Z7U4@2|Bacteria,2GN2S@201174|Actinobacteria	201174|Actinobacteria	S	succinate dehydrogenase	sdhC	-	-	ko:K00241	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
REGS3_k127_7989064_0	1313172.YM304_07480	0.0	1062.0	COG1053@1|root,COG1053@2|Bacteria,2GJ45@201174|Actinobacteria,4CN0E@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Fumarate reductase flavoprotein C-term	sdhA	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
REGS3_k127_7989064_12	1313172.YM304_07490	1.103e-132	428.0	COG0479@1|root,COG0479@2|Bacteria,2GP9C@201174|Actinobacteria,4CNED@84992|Acidimicrobiia	84992|Acidimicrobiia	C	2Fe-2S iron-sulfur cluster binding domain	sdhB	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3
REGS3_k127_7989064_5	1313172.YM304_07510	8.363e-238	772.0	COG3250@1|root,COG3250@2|Bacteria,2GM69@201174|Actinobacteria	201174|Actinobacteria	G	beta-mannosidase	csxA	GO:0000272,GO:0003674,GO:0003824,GO:0004553,GO:0005575,GO:0005576,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0016052,GO:0016787,GO:0016798,GO:0043170,GO:0044238,GO:0071704,GO:1901575	3.2.1.165,3.2.1.25	ko:K01192,ko:K15855	ko00511,ko00520,ko01100,ko04142,map00511,map00520,map01100,map04142	-	R01966	RC00049	ko00000,ko00001,ko01000	-	-	-	F5_F8_type_C,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
REGS3_k127_7989064_6	1313172.YM304_07520	4.524e-231	722.0	COG1239@1|root,COG1239@2|Bacteria,2GMRS@201174|Actinobacteria,4CMSG@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Mg-chelatase subunit ChlI	-	-	6.6.1.1	ko:K03405	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03877	RC01012	ko00000,ko00001,ko01000	-	-	-	-
REGS3_k127_7989064_37	1313172.YM304_07550	3.126e-26	122.0	COG2723@1|root,COG2723@2|Bacteria	2|Bacteria	G	beta-glucosidase activity	rfbD	-	1.1.1.133,3.2.1.21	ko:K00067,ko:K05350	ko00460,ko00500,ko00521,ko00523,ko00940,ko01100,ko01110,ko01130,map00460,map00500,map00521,map00523,map00940,map01100,map01110,map01130	M00793	R00026,R02558,R02777,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00182,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_1,RmlD_sub_bind
REGS3_k127_7989064_26	1313172.YM304_07560	1.688e-78	265.0	COG2114@1|root,COG2114@2|Bacteria	2|Bacteria	T	Pfam Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_molyb
REGS3_k127_7989064_2	1313172.YM304_07620	2.5e-323	1000.0	COG4867@1|root,COG4867@2|Bacteria,2H14W@201174|Actinobacteria,4CMU5@84992|Acidimicrobiia	84992|Acidimicrobiia	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_7989064_38	1122611.KB903958_gene4154	7.776e-25	110.0	COG1595@1|root,COG1595@2|Bacteria,2IHGE@201174|Actinobacteria,4EJG8@85012|Streptosporangiales	201174|Actinobacteria	K	Sigma-70, region 4	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
REGS3_k127_7989064_31	1313172.YM304_07630	3.09e-37	143.0	2CC1Y@1|root,32RUK@2|Bacteria,2IQ4Q@201174|Actinobacteria,4CP4B@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA	-	-	-	ko:K18955	-	-	-	-	ko00000,ko03000	-	-	-	Whib
REGS3_k127_7989064_40	1313172.YM304_07640	2.687e-08	58.0	COG1826@1|root,COG1826@2|Bacteria	2|Bacteria	U	protein secretion	tatA	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
REGS3_k127_7989064_35	1313172.YM304_07660	1.722e-31	126.0	2CC1Y@1|root,32TCV@2|Bacteria,2HGD4@201174|Actinobacteria,4CNAQ@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA	-	-	-	ko:K18955	-	-	-	-	ko00000,ko03000	-	-	-	Whib
REGS3_k127_7989064_34	1313172.YM304_07670	1.441e-33	134.0	2FBA6@1|root,343GA@2|Bacteria,2H78Y@201174|Actinobacteria,4CN8Z@84992|Acidimicrobiia	84992|Acidimicrobiia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_7989064_3	1313172.YM304_07680	1.392e-287	902.0	COG0855@1|root,COG0855@2|Bacteria,2GJ0B@201174|Actinobacteria,4CMSJ@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
REGS3_k127_7989064_16	446470.Snas_2214	2.336e-106	353.0	COG1117@1|root,COG1117@2|Bacteria,2GJQ3@201174|Actinobacteria,4EXWB@85014|Glycomycetales	201174|Actinobacteria	P	ATPases associated with a variety of cellular activities	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
REGS3_k127_7989064_23	1313172.YM304_07730	5.776e-86	291.0	COG0704@1|root,COG0704@2|Bacteria,2HGEH@201174|Actinobacteria,4CNCK@84992|Acidimicrobiia	84992|Acidimicrobiia	P	PhoU domain	-	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
REGS3_k127_7989064_25	1313172.YM304_07740	1.548e-83	290.0	COG5002@1|root,COG5002@2|Bacteria,2GJY7@201174|Actinobacteria,4CMZJ@84992|Acidimicrobiia	84992|Acidimicrobiia	F	His Kinase A (phosphoacceptor) domain	-	-	2.7.13.3	ko:K07768	ko02020,map02020	M00443	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA
REGS3_k127_7989064_18	1313172.YM304_07750	2.213e-99	329.0	COG0745@1|root,COG0745@2|Bacteria,2GKFS@201174|Actinobacteria,4CMYH@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Transcriptional regulatory protein, C terminal	-	-	-	ko:K07776	ko02020,map02020	M00443	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
REGS3_k127_7989064_17	1313172.YM304_07790	6.588e-106	359.0	COG0477@1|root,COG2814@2|Bacteria,2GKRT@201174|Actinobacteria,4CN19@84992|Acidimicrobiia	84992|Acidimicrobiia	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
REGS3_k127_7989064_13	1313172.YM304_07800	1.055e-129	430.0	COG5282@1|root,COG5282@2|Bacteria,2GJ8E@201174|Actinobacteria,4CNC4@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Pfam:Zinicin_2	-	-	-	-	-	-	-	-	-	-	-	-	Zincin_2
REGS3_k127_7989064_19	1313172.YM304_09000	3.6e-99	345.0	COG0451@1|root,COG0451@2|Bacteria,2GNT1@201174|Actinobacteria	201174|Actinobacteria	GM	Epimerase dehydratase	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
REGS3_k127_7989064_29	1313172.YM304_09020	2.724e-69	241.0	COG0314@1|root,COG0314@2|Bacteria,2HG21@201174|Actinobacteria,4CN80@84992|Acidimicrobiia	84992|Acidimicrobiia	H	MoaE protein	-	-	2.8.1.12	ko:K03635	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoaE
REGS3_k127_7989064_8	1313172.YM304_09040	4.897e-195	610.0	COG1077@1|root,COG1077@2|Bacteria,2GMD1@201174|Actinobacteria,4CMUQ@84992|Acidimicrobiia	201174|Actinobacteria	D	Cell division protein FtsA	mreB	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
REGS3_k127_7989064_20	2074.JNYD01000031_gene6583	8.059e-96	327.0	COG1024@1|root,COG1024@2|Bacteria,2H25N@201174|Actinobacteria,4EBYU@85010|Pseudonocardiales	201174|Actinobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
REGS3_k127_7989064_9	1112214.AHIS01000033_gene1098	8.436e-153	501.0	COG0557@1|root,COG0557@2|Bacteria,1R4RK@1224|Proteobacteria,2TTRC@28211|Alphaproteobacteria,2K2TK@204457|Sphingomonadales	204457|Sphingomonadales	K	RNB	-	-	-	-	-	-	-	-	-	-	-	-	RNB
REGS3_k127_7989064_24	1352941.M877_24975	1.732e-84	301.0	COG2133@1|root,COG2133@2|Bacteria,2I9ZW@201174|Actinobacteria	201174|Actinobacteria	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	CBM_2,GSDH
REGS3_k127_7989064_11	1313172.YM304_09070	4.167e-141	452.0	COG1946@1|root,COG1946@2|Bacteria,2GJ1B@201174|Actinobacteria,4CMRR@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Thioesterase-like superfamily	-	-	-	ko:K10805	ko01040,map01040	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	-	4HBT_3
REGS3_k127_7989064_21	1313172.YM304_09080	2.541e-94	323.0	COG0778@1|root,COG0778@2|Bacteria,2HI8Q@201174|Actinobacteria	201174|Actinobacteria	C	Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
REGS3_k127_7989064_27	1283287.KB822576_gene3611	8.74e-78	273.0	COG4122@1|root,COG4122@2|Bacteria,2GQ0Z@201174|Actinobacteria,4DQ9V@85009|Propionibacteriales	201174|Actinobacteria	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_24
REGS3_k127_7989064_7	1122622.ATWJ01000009_gene3137	4.21e-201	638.0	COG1012@1|root,COG1012@2|Bacteria,2GMNB@201174|Actinobacteria,4FJ2A@85021|Intrasporangiaceae	201174|Actinobacteria	C	Aldehyde dehydrogenase family	-	-	1.2.1.3	ko:K00128,ko:K22187	ko00010,ko00040,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00040,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146,R11768	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
REGS3_k127_7989064_10	1313172.YM304_09250	5.837e-150	484.0	COG3387@1|root,COG3387@2|Bacteria,2GKU7@201174|Actinobacteria,4CN1W@84992|Acidimicrobiia	84992|Acidimicrobiia	G	PFAM Glycoside hydrolase 15-related	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_7989064_39	1169161.KB897734_gene385	1.633e-08	57.0	COG0500@1|root,COG2226@2|Bacteria,2H38T@201174|Actinobacteria	201174|Actinobacteria	Q	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
REGS3_k127_7995947_2	749414.SBI_02891	1.485e-52	192.0	COG1477@1|root,COG1477@2|Bacteria,2GN6F@201174|Actinobacteria	201174|Actinobacteria	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	-	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
REGS3_k127_7995947_5	1306990.BARG01000010_gene772	8.769e-25	114.0	COG3976@1|root,COG3976@2|Bacteria,2GTTI@201174|Actinobacteria	201174|Actinobacteria	S	FMN-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	FMN_bind
REGS3_k127_7995947_1	1463881.KL591018_gene270	3.428e-97	322.0	COG1136@1|root,COG1136@2|Bacteria,2GK3I@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
REGS3_k127_7995947_0	298655.KI912266_gene2835	7.631e-138	473.0	COG0577@1|root,COG4591@1|root,COG0577@2|Bacteria,COG4591@2|Bacteria,2ICGU@201174|Actinobacteria	201174|Actinobacteria	MV	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX
REGS3_k127_7995947_4	1380356.JNIK01000001_gene2152	5.824e-29	128.0	29BBV@1|root,2ZCHD@2|Bacteria,2I82W@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	NAGPA
REGS3_k127_7995947_3	1313172.YM304_13940	1.172e-32	136.0	COG1272@1|root,COG1272@2|Bacteria,2GJGQ@201174|Actinobacteria,4CNX1@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Haemolysin-III related	-	-	-	ko:K11068	-	-	-	-	ko00000,ko02042	-	-	-	HlyIII
REGS3_k127_8066384_18	112098.XP_008619723.1	6.783e-06	49.0	COG1028@1|root,KOG0725@2759|Eukaryota	2759|Eukaryota	IQ	oxidation-reduction process	-	GO:0003674,GO:0003824,GO:0004033,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008106,GO:0008150,GO:0008152,GO:0009507,GO:0009536,GO:0016491,GO:0016614,GO:0016616,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0055114	1.1.1.100,2.3.1.133	ko:K00059,ko:K13065	ko00061,ko00333,ko00780,ko00940,ko00941,ko00945,ko01040,ko01100,ko01110,ko01130,ko01212,map00061,map00333,map00780,map00940,map00941,map00945,map01040,map01100,map01110,map01130,map01212	M00039,M00083,M00572	R01945,R02416,R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07432,R07433,R07759,R07763,R10116,R10120,R11671	RC00004,RC00029,RC00055,RC00117,RC02864	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
REGS3_k127_8066384_15	365528.KB891126_gene3237	1.088e-23	104.0	2CJ4Q@1|root,32S97@2|Bacteria	2|Bacteria	S	Ethyl tert-butyl ether degradation EthD	ethD	-	-	-	-	-	-	-	-	-	-	-	EthD
REGS3_k127_8066384_10	1313172.YM304_27650	6.727e-78	266.0	COG5587@1|root,COG5587@2|Bacteria,2IJG5@201174|Actinobacteria	201174|Actinobacteria	S	Conserved hypothetical protein (DUF2461)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2461
REGS3_k127_8066384_13	1122137.AQXF01000002_gene79	3.028e-49	185.0	COG2345@1|root,COG2345@2|Bacteria,1RDXT@1224|Proteobacteria,2U1K1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_11,HTH_5,MarR_2,PadR,Replic_Relax
REGS3_k127_8066384_0	1313172.YM304_27600	2.398e-259	807.0	COG0031@1|root,COG0031@2|Bacteria,2IEI6@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the cysteine synthase cystathionine beta- synthase family	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_8066384_3	1313172.YM304_27590	2.022e-123	408.0	COG0498@1|root,COG0498@2|Bacteria,2IH7W@201174|Actinobacteria	201174|Actinobacteria	E	Pyridoxal-phosphate dependent enzyme	-	-	-	-	-	-	-	-	-	-	-	-	PALP
REGS3_k127_8066384_12	1056816.JAFQ01000003_gene7357	5.974e-51	185.0	COG3576@1|root,COG3576@2|Bacteria,2I7E8@201174|Actinobacteria,4G9QX@85025|Nocardiaceae	201174|Actinobacteria	S	Pfam:Pyridox_oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
REGS3_k127_8066384_8	1313172.YM304_27560	1.292e-99	329.0	COG0740@1|root,COG0740@2|Bacteria,2GK5C@201174|Actinobacteria,4CN0W@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	-	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
REGS3_k127_8066384_1	1313172.YM304_27540	3.007e-176	565.0	COG0606@1|root,COG0606@2|Bacteria,2GJIQ@201174|Actinobacteria	201174|Actinobacteria	O	PFAM magnesium chelatase ChlI subunit	comM	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
REGS3_k127_8066384_9	1313172.YM304_27530	1.728e-98	334.0	COG0758@1|root,COG0758@2|Bacteria,2GKDA@201174|Actinobacteria	201174|Actinobacteria	LU	DNA protecting protein DprA	dprA	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
REGS3_k127_8066384_5	1313172.YM304_27520	1.245e-116	383.0	COG4974@1|root,COG4974@2|Bacteria,2GNDP@201174|Actinobacteria,4CN5T@84992|Acidimicrobiia	84992|Acidimicrobiia	L	Phage integrase, N-terminal SAM-like domain	-	-	-	ko:K03733	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
REGS3_k127_8066384_7	1313172.YM304_27510	5.443e-101	350.0	COG1191@1|root,COG1191@2|Bacteria,2GKBK@201174|Actinobacteria,4CMYZ@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Sigma-70 region 3	-	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_r2,Sigma70_r3,Sigma70_r4
REGS3_k127_8066384_14	1313172.YM304_27500	2.059e-34	139.0	COG0739@1|root,COG0739@2|Bacteria	2|Bacteria	M	heme binding	-	-	3.4.24.75	ko:K08259,ko:K21472	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
REGS3_k127_8066384_2	1313172.YM304_27490	1.066e-125	409.0	COG0052@1|root,COG0052@2|Bacteria,2GMYC@201174|Actinobacteria,4CMWX@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Ribosomal protein S2	rpsB	-	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
REGS3_k127_8066384_6	1313172.YM304_27480	6.995e-109	357.0	COG0264@1|root,COG0264@2|Bacteria,2GK4M@201174|Actinobacteria,4CMXN@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	-	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
REGS3_k127_8066384_4	1313172.YM304_27470	9.083e-121	391.0	COG0528@1|root,COG0528@2|Bacteria,2GKWQ@201174|Actinobacteria,4CMRF@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
REGS3_k127_8066384_11	1313172.YM304_27460	5.63e-77	263.0	COG0233@1|root,COG0233@2|Bacteria,2GJ9J@201174|Actinobacteria,4CN2Z@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	-	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
REGS3_k127_8066384_16	1313172.YM304_27450	8.128e-21	100.0	COG0575@1|root,COG0575@2|Bacteria,2I7ZA@201174|Actinobacteria	201174|Actinobacteria	I	Belongs to the CDS family	cdsA	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
REGS3_k127_8070426_4	1210045.ALNP01000038_gene2289	2.617e-69	248.0	COG3533@1|root,COG3533@2|Bacteria,2GM60@201174|Actinobacteria	201174|Actinobacteria	G	protein conserved in bacteria	-	-	-	ko:K09955	-	-	-	-	ko00000	-	-	-	Glyco_hydro_127
REGS3_k127_8070426_2	1038859.AXAU01000001_gene2756	2.652e-121	400.0	COG0508@1|root,COG0508@2|Bacteria,1MVDC@1224|Proteobacteria,2TTKB@28211|Alphaproteobacteria,3JWKU@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	e3 binding domain	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
REGS3_k127_8070426_0	991905.SL003B_1083	1.109e-141	461.0	COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,2TRFK@28211|Alphaproteobacteria,4BRTY@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Transketolase, pyrimidine binding domain	-	-	1.2.4.1	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
REGS3_k127_8070426_1	1038867.AXAY01000038_gene737	1.745e-125	425.0	COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,2TSEI@28211|Alphaproteobacteria,3JV4M@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Dehydrogenase E1 component	-	-	1.2.4.1	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
REGS3_k127_8070426_5	1313172.YM304_13940	3.267e-56	204.0	COG1272@1|root,COG1272@2|Bacteria,2GJGQ@201174|Actinobacteria,4CNX1@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Haemolysin-III related	-	-	-	ko:K11068	-	-	-	-	ko00000,ko02042	-	-	-	HlyIII
REGS3_k127_8070426_6	292459.STH2528	9.408e-21	100.0	COG1595@1|root,COG1595@2|Bacteria,1VD37@1239|Firmicutes,25BCE@186801|Clostridia	186801|Clostridia	K	PFAM sigma-70 region 2 domain protein	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
REGS3_k127_8070426_3	1313172.YM304_32760	8.152e-85	284.0	COG1960@1|root,COG1960@2|Bacteria,2GJDT@201174|Actinobacteria	201174|Actinobacteria	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
REGS3_k127_8096359_1	1313172.YM304_05570	4.151e-71	243.0	COG0745@1|root,COG0745@2|Bacteria,2GIZB@201174|Actinobacteria,4CMX9@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Transcriptional regulatory protein, C terminal	-	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
REGS3_k127_8096359_0	1313172.YM304_05580	1.03e-86	304.0	COG5002@1|root,COG5002@2|Bacteria,2I2DU@201174|Actinobacteria,4CN2H@84992|Acidimicrobiia	84992|Acidimicrobiia	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	2.7.13.3	ko:K02484	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
REGS3_k127_8104021_2	1313172.YM304_37360	2.021e-112	380.0	COG1322@1|root,COG1322@2|Bacteria,2GP4U@201174|Actinobacteria,4CN7J@84992|Acidimicrobiia	84992|Acidimicrobiia	S	RmuC family	-	-	-	ko:K09760	-	-	-	-	ko00000	-	-	-	RmuC
REGS3_k127_8104021_0	1313172.YM304_02620	2.483e-256	803.0	COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4CMW8@84992|Acidimicrobiia	84992|Acidimicrobiia	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
REGS3_k127_8104021_1	1313172.YM304_02630	2.534e-145	478.0	COG0596@1|root,COG0596@2|Bacteria,2GJYS@201174|Actinobacteria	2|Bacteria	NU	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4
REGS3_k127_8104021_5	1120936.KB907215_gene3999	9.394e-09	63.0	COG2018@1|root,COG2018@2|Bacteria,2IIPN@201174|Actinobacteria,4EK6Z@85012|Streptosporangiales	201174|Actinobacteria	S	Roadblock/LC7 domain	-	-	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
REGS3_k127_8104021_3	1313172.YM304_02650	2.006e-60	216.0	COG2229@1|root,COG2229@2|Bacteria	2|Bacteria	S	signal recognition particle binding	spoIVA	-	-	ko:K06398,ko:K06945	-	-	-	-	ko00000	-	-	-	ATP_bind_1,Spore_IV_A
REGS3_k127_8118767_0	1313172.YM304_10810	1.091e-294	923.0	COG0058@1|root,COG0058@2|Bacteria,2GIVZ@201174|Actinobacteria	201174|Actinobacteria	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	glgP	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
REGS3_k127_8118767_13	1192868.CAIU01000023_gene3412	1.761e-51	199.0	COG0697@1|root,COG0697@2|Bacteria,1RHZ4@1224|Proteobacteria,2UAU7@28211|Alphaproteobacteria,43IZY@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
REGS3_k127_8118767_9	1313172.YM304_10790	4.344e-106	349.0	COG1024@1|root,COG1024@2|Bacteria,2GJW5@201174|Actinobacteria,4CMYM@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
REGS3_k127_8118767_6	1313172.YM304_10780	6.427e-156	501.0	COG1703@1|root,COG1703@2|Bacteria,2GME8@201174|Actinobacteria,4CMYQ@84992|Acidimicrobiia	84992|Acidimicrobiia	E	ArgK protein	-	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK
REGS3_k127_8118767_16	1313172.YM304_10770	7.261e-26	108.0	COG0694@1|root,COG0694@2|Bacteria,2HGE4@201174|Actinobacteria,4CNCF@84992|Acidimicrobiia	84992|Acidimicrobiia	O	NifU-like domain	-	-	-	-	-	-	-	-	-	-	-	-	NifU
REGS3_k127_8118767_3	1313172.YM304_10760	7.25e-191	609.0	COG0766@1|root,COG0766@2|Bacteria,2GJPW@201174|Actinobacteria,4CMR2@84992|Acidimicrobiia	84992|Acidimicrobiia	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
REGS3_k127_8118767_5	1313172.YM304_10750	2.426e-172	560.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	ko:K08369	-	-	-	-	ko00000,ko02000	2.A.1	-	-	MFS_1,Sugar_tr
REGS3_k127_8118767_12	743718.Isova_0446	1.455e-52	200.0	COG3571@1|root,COG3571@2|Bacteria,2GKKE@201174|Actinobacteria,4F4CP@85017|Promicromonosporaceae	201174|Actinobacteria	S	Hydrolase of the alpha beta-hydrolase	-	-	-	ko:K07020	-	-	-	-	ko00000	-	-	-	DLH
REGS3_k127_8118767_10	1313172.YM304_10740	4.749e-87	293.0	COG2214@1|root,COG2214@2|Bacteria,2H5PV@201174|Actinobacteria	201174|Actinobacteria	O	DnaJ molecular chaperone homology domain	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_8118767_14	1313172.YM304_10730	9.999e-36	146.0	294NP@1|root,2ZS20@2|Bacteria,2H9SR@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_8118767_4	1313172.YM304_10710	2.797e-174	567.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,2HF92@201174|Actinobacteria,4CNT6@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Prolyl oligopeptidase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S9
REGS3_k127_8118767_7	1313172.YM304_10700	1.117e-145	471.0	COG1494@1|root,COG1494@2|Bacteria,2GMQU@201174|Actinobacteria,4CMQH@84992|Acidimicrobiia	84992|Acidimicrobiia	G	Bacterial fructose-1,6-bisphosphatase, glpX-encoded	glpX	-	3.1.3.11	ko:K02446	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00165,M00167	R00762,R04780	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_glpX
REGS3_k127_8118767_11	58123.JOFJ01000003_gene2150	3.955e-56	207.0	COG0300@1|root,COG0300@2|Bacteria,2GKJE@201174|Actinobacteria,4EGF3@85012|Streptosporangiales	201174|Actinobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	ko:K07124	-	-	-	-	ko00000	-	-	-	adh_short
REGS3_k127_8118767_15	1313172.YM304_10670	1.327e-34	147.0	COG0355@1|root,COG0355@2|Bacteria	2|Bacteria	C	proton-transporting ATP synthase activity, rotational mechanism	atpC	GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045259,GO:0045260,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	iLJ478.TM1609	ATP-synt_DE,ATP-synt_DE_N
REGS3_k127_8118767_2	1313172.YM304_10660	4.078e-258	801.0	COG0055@1|root,COG0055@2|Bacteria,2GIY6@201174|Actinobacteria,4CMWB@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
REGS3_k127_8118767_8	1313172.YM304_10650	9.577e-130	421.0	COG0224@1|root,COG3743@1|root,COG0224@2|Bacteria,COG3743@2|Bacteria,2GJ7Q@201174|Actinobacteria,4CN1H@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	-	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
REGS3_k127_8118767_1	1313172.YM304_10640	4.547e-274	850.0	COG0056@1|root,COG0056@2|Bacteria,2GJRJ@201174|Actinobacteria,4CMTI@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
REGS3_k127_8118767_17	1313172.YM304_10630	1.853e-14	73.0	COG0712@1|root,COG0712@2|Bacteria,2HGFG@201174|Actinobacteria,4CND3@84992|Acidimicrobiia	84992|Acidimicrobiia	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	-	-	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	OSCP
REGS3_k127_8123805_12	1454010.JEOE01000001_gene760	2.363e-38	147.0	COG0346@1|root,COG0346@2|Bacteria,2IFMD@201174|Actinobacteria,4F2NU@85016|Cellulomonadaceae	201174|Actinobacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_8123805_10	1463856.JOHY01000003_gene5057	2.06e-56	205.0	COG3550@1|root,COG3550@2|Bacteria,2I2QD@201174|Actinobacteria	201174|Actinobacteria	S	MDMPI C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_C,MDMPI_N
REGS3_k127_8123805_7	1313172.YM304_12150	3.182e-83	290.0	COG0316@1|root,COG0694@1|root,COG0316@2|Bacteria,COG0694@2|Bacteria,2HGAJ@201174|Actinobacteria,4CN9Q@84992|Acidimicrobiia	84992|Acidimicrobiia	O	NifU-like domain	-	-	-	ko:K07400	-	-	-	-	ko00000	-	-	-	NifU
REGS3_k127_8123805_6	468556.AQYG01000047_gene1456	1.941e-85	291.0	COG1028@1|root,COG1028@2|Bacteria,2IEID@201174|Actinobacteria,4GG77@85026|Gordoniaceae	201174|Actinobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
REGS3_k127_8123805_5	1120934.KB894409_gene6490	1.599e-93	318.0	COG0053@1|root,COG0053@2|Bacteria,2GKSG@201174|Actinobacteria,4DYCH@85010|Pseudonocardiales	201174|Actinobacteria	P	cation diffusion facilitator family transporter	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
REGS3_k127_8123805_2	1122609.AUGT01000002_gene3815	6.112e-107	370.0	COG0697@1|root,COG0697@2|Bacteria,2GU83@201174|Actinobacteria	201174|Actinobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
REGS3_k127_8123805_0	1121920.AUAU01000012_gene2702	1.294e-179	574.0	COG0702@1|root,COG0702@2|Bacteria,3Y666@57723|Acidobacteria	57723|Acidobacteria	GM	Protein of unknown function (DUF2867)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2867,NAD_binding_10
REGS3_k127_8123805_9	1089545.KB913037_gene8157	4.72e-62	216.0	COG0748@1|root,COG0748@2|Bacteria,2I5ST@201174|Actinobacteria,4EE0P@85010|Pseudonocardiales	201174|Actinobacteria	P	Pfam:DUF385	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red
REGS3_k127_8123805_11	1313172.YM304_11770	3.476e-40	158.0	COG1564@1|root,COG1564@2|Bacteria	2|Bacteria	H	THIamine pyrophosphokinase	thiN	-	2.7.6.2	ko:K00949	ko00730,ko01100,map00730,map01100	-	R00619	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	TPK_B1_binding,TPK_catalytic
REGS3_k127_8123805_3	1116232.AHBF01000040_gene5293	8.38e-106	357.0	COG4143@1|root,COG4143@2|Bacteria,2GMWD@201174|Actinobacteria	201174|Actinobacteria	H	ABC transporter, periplasmic binding protein, thiB subfamily	thiB	-	-	ko:K02064	ko02010,map02010	M00191	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.19	-	-	SBP_bac_6
REGS3_k127_8123805_1	1313172.YM304_11750	1.021e-165	538.0	COG1178@1|root,COG1178@2|Bacteria,2GKDH@201174|Actinobacteria	201174|Actinobacteria	P	ABC-type Fe3 transport system permease component	thiP	-	-	ko:K02011,ko:K02063	ko02010,map02010	M00190,M00191	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10,3.A.1.19	-	-	BPD_transp_1
REGS3_k127_8123805_8	1449976.KALB_912	2.577e-65	233.0	COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria,4DXIX@85010|Pseudonocardiales	201174|Actinobacteria	E	ABC transporter	fbpC	-	3.6.3.30	ko:K02010,ko:K02052,ko:K02062	ko02010,ko02024,map02010,map02024	M00190,M00191,M00193	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10,3.A.1.11,3.A.1.19	-	-	ABC_tran,TOBE_2
REGS3_k127_8123805_4	1313172.YM304_12110	9.479e-103	342.0	COG0496@1|root,COG0496@2|Bacteria,2IFAX@201174|Actinobacteria	201174|Actinobacteria	S	survival protein SurE	surE	-	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	SurE
REGS3_k127_8123805_13	101510.RHA1_ro01850	1.692e-24	116.0	COG0673@1|root,COG0673@2|Bacteria,2GM7J@201174|Actinobacteria,4G8K2@85025|Nocardiaceae	201174|Actinobacteria	S	oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
REGS3_k127_8123805_14	1210045.ALNP01000024_gene539	3.086e-10	66.0	COG0454@1|root,COG0456@2|Bacteria,2IMKI@201174|Actinobacteria	201174|Actinobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
REGS3_k127_8189920_0	1386089.N865_10975	1.69e-304	1005.0	COG2132@1|root,COG2132@2|Bacteria,2H743@201174|Actinobacteria,4FIJM@85021|Intrasporangiaceae	201174|Actinobacteria	Q	IPT/TIG domain	-	-	-	-	-	-	-	-	-	-	-	-	TIG,fn3_3
REGS3_k127_8229918_4	526225.Gobs_1045	2.371e-39	156.0	COG1752@1|root,COG1752@2|Bacteria,2IB0F@201174|Actinobacteria,4ET56@85013|Frankiales	201174|Actinobacteria	S	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
REGS3_k127_8229918_1	1540221.JQNI01000002_gene2017	8.743e-97	332.0	COG0665@1|root,COG0665@2|Bacteria,1WKYI@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
REGS3_k127_8229918_0	34007.IT40_07990	8.915e-305	960.0	COG0753@1|root,COG0753@2|Bacteria,1MUXZ@1224|Proteobacteria,2TSG9@28211|Alphaproteobacteria,2PU1S@265|Paracoccus	28211|Alphaproteobacteria	P	Serves to protect cells from the toxic effects of hydrogen peroxide	katE	-	1.11.1.6	ko:K03781	ko00380,ko00630,ko01110,ko01130,ko01200,ko04011,ko04016,ko04068,ko04146,ko04211,ko04212,ko04213,ko05014,map00380,map00630,map01110,map01130,map01200,map04011,map04016,map04068,map04146,map04211,map04212,map04213,map05014	M00532	R00009,R00602,R02670	RC00034,RC00767,RC02141,RC02755	ko00000,ko00001,ko00002,ko01000	-	-	-	Catalase,Catalase-rel
REGS3_k127_8229918_3	1229780.BN381_110015	7.229e-55	206.0	COG5592@1|root,COG5592@2|Bacteria,2IGW0@201174|Actinobacteria	201174|Actinobacteria	S	Pfam Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
REGS3_k127_8229918_5	1246995.AFR_20090	4.07e-37	145.0	COG4572@1|root,COG4572@2|Bacteria,2IMHQ@201174|Actinobacteria	201174|Actinobacteria	S	PFAM ChaB family protein	-	-	-	-	-	-	-	-	-	-	-	-	ChaB,Rho_N
REGS3_k127_8229918_7	58123.JOFJ01000010_gene874	1.035e-16	86.0	COG5592@1|root,COG5592@2|Bacteria,2GNJ6@201174|Actinobacteria,4EJ9R@85012|Streptosporangiales	201174|Actinobacteria	S	Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
REGS3_k127_8229918_2	1299327.I546_3457	2.895e-63	222.0	28MHV@1|root,2ZAUP@2|Bacteria,2IA17@201174|Actinobacteria,23835@1762|Mycobacteriaceae	201174|Actinobacteria	S	Tocopherol cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Tocopherol_cycl
REGS3_k127_82397_1	357808.RoseRS_0827	7.485e-152	496.0	COG1523@1|root,COG1523@2|Bacteria,2G86B@200795|Chloroflexi,3763Y@32061|Chloroflexia	32061|Chloroflexia	G	Belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
REGS3_k127_82397_2	1313172.YM304_33360	3.266e-144	463.0	COG0714@1|root,COG0714@2|Bacteria,2GMM2@201174|Actinobacteria,4CMRT@84992|Acidimicrobiia	84992|Acidimicrobiia	O	AAA domain (dynein-related subfamily)	-	-	-	-	-	-	-	-	-	-	-	-	AAA_5
REGS3_k127_82397_0	1313172.YM304_33370	5.497e-153	500.0	COG3552@1|root,COG3552@2|Bacteria,2GNTS@201174|Actinobacteria,4CNNX@84992|Acidimicrobiia	84992|Acidimicrobiia	S	von Willebrand factor (vWF) type A domain	-	-	-	ko:K07161	-	-	-	-	ko00000	-	-	-	VWA_CoxE
REGS3_k127_82397_7	1313172.YM304_33380	1.453e-45	169.0	COG1975@1|root,COG1975@2|Bacteria,2IJ4H@201174|Actinobacteria	201174|Actinobacteria	O	XdhC and CoxI family	-	-	-	-	-	-	-	-	-	-	-	-	XdhC_CoxI
REGS3_k127_82397_3	1313172.YM304_33390	1.406e-129	419.0	COG1975@1|root,COG1975@2|Bacteria,2GIZS@201174|Actinobacteria,4CN04@84992|Acidimicrobiia	84992|Acidimicrobiia	O	XdhC Rossmann domain	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI
REGS3_k127_82397_8	1313172.YM304_33400	1.593e-32	136.0	COG0791@1|root,COG0791@2|Bacteria	2|Bacteria	M	cysteine-type peptidase activity	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Glucosaminidase,NLPC_P60
REGS3_k127_82397_10	985053.VMUT_1913	6.212e-10	68.0	COG2068@1|root,arCOG01873@2157|Archaea,2XQP2@28889|Crenarchaeota	28889|Crenarchaeota	S	MobA-like NTP transferase domain	-	-	2.7.7.76	ko:K07141	ko00790,map00790	-	R11582	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
REGS3_k127_82397_4	1313172.YM304_33420	4.632e-66	233.0	COG3427@1|root,COG3427@2|Bacteria,2GKTQ@201174|Actinobacteria,4CN4Y@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Carbon monoxide dehydrogenase subunit G (CoxG)	-	-	-	ko:K09386	-	-	-	-	ko00000	-	-	-	COXG
REGS3_k127_82397_6	1313172.YM304_33430	8.255e-51	184.0	COG1507@1|root,COG1507@2|Bacteria,2HGD5@201174|Actinobacteria,4CNAS@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Protein of unknown function (DUF501)	-	-	-	ko:K09009	-	-	-	-	ko00000	-	-	-	DUF501
REGS3_k127_82397_9	1313172.YM304_33440	6.633e-19	100.0	COG0248@1|root,COG0248@2|Bacteria	2|Bacteria	FP	Ppx GppA phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_82397_5	1313172.YM304_33450	1.197e-63	228.0	COG1670@1|root,COG1670@2|Bacteria,2HFKU@201174|Actinobacteria,4CP4F@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Acetyltransferase (GNAT) domain	-	-	2.3.1.128	ko:K03790	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_3
REGS3_k127_8292421_1	595593.JREV01000054_gene2398	6.101e-59	216.0	COG0524@1|root,COG0524@2|Bacteria,2GP1C@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the carbohydrate kinase PfkB family	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
REGS3_k127_8292421_0	266834.SM_b20973	0.0	1122.0	COG0160@1|root,COG0739@1|root,COG2334@1|root,COG0160@2|Bacteria,COG0739@2|Bacteria,COG2334@2|Bacteria,1MX0Y@1224|Proteobacteria,2TRAZ@28211|Alphaproteobacteria,4BM4R@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	APH,Aminotran_3,Peptidase_M23
REGS3_k127_8302285_7	479433.Caci_8740	2.39e-60	215.0	COG0318@1|root,COG0318@2|Bacteria,2GMVB@201174|Actinobacteria	201174|Actinobacteria	IQ	Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
REGS3_k127_8302285_1	710111.FraQA3DRAFT_1346	1.34e-117	395.0	COG0318@1|root,COG0318@2|Bacteria,2I91U@201174|Actinobacteria	201174|Actinobacteria	IQ	AMP-binding enzyme	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
REGS3_k127_8302285_2	1968.JOEV01000021_gene5974	2.643e-114	381.0	COG1062@1|root,COG1062@2|Bacteria,2GM8C@201174|Actinobacteria	201174|Actinobacteria	C	alcohol dehydrogenase	-	-	1.1.1.1,1.1.1.284	ko:K00121	ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
REGS3_k127_8302285_0	1155718.KB891885_gene6323	3.467e-187	623.0	COG2159@1|root,COG2159@2|Bacteria,2GKG2@201174|Actinobacteria	201174|Actinobacteria	S	Pfam Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
REGS3_k127_8302285_3	479433.Caci_8759	1.591e-89	302.0	COG1024@1|root,COG1024@2|Bacteria,2GJY4@201174|Actinobacteria	201174|Actinobacteria	I	Enoyl-CoA hydratase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
REGS3_k127_8302285_4	1123320.KB889685_gene2187	6.595e-75	259.0	COG1028@1|root,COG1028@2|Bacteria,2GK20@201174|Actinobacteria	201174|Actinobacteria	IQ	Short-chain dehydrogenase reductase sdr	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
REGS3_k127_8302285_5	1121949.AQXT01000002_gene2477	2.314e-66	240.0	COG2175@1|root,COG2175@2|Bacteria,1MV5K@1224|Proteobacteria,2TQTZ@28211|Alphaproteobacteria,43ZCR@69657|Hyphomonadaceae	28211|Alphaproteobacteria	Q	Taurine catabolism dioxygenase TauD, TfdA family	-	-	1.14.11.17	ko:K03119	ko00430,ko00920,map00430,map00920	-	R05320	RC01331	ko00000,ko00001,ko01000	-	-	-	TauD
REGS3_k127_8302285_6	1206744.BAGL01000121_gene3124	4.979e-65	229.0	COG2141@1|root,COG2141@2|Bacteria,2HVKH@201174|Actinobacteria,4FVX1@85025|Nocardiaceae	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
REGS3_k127_8362865_18	1313172.YM304_00120	7.592e-32	125.0	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	-	-	3.4.11.5	ko:K01259,ko:K19311	ko00330,map00330	-	R00135	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Abhydrolase_1,Hydrolase_4
REGS3_k127_8362865_16	1229780.BN381_100221	4.819e-40	156.0	COG0735@1|root,COG0735@2|Bacteria	2|Bacteria	P	belongs to the Fur family	-	-	-	ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
REGS3_k127_8362865_11	1313172.YM304_00110	3.839e-81	283.0	COG1748@1|root,COG1748@2|Bacteria,2H8X8@201174|Actinobacteria	201174|Actinobacteria	E	Saccharopine dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_8362865_0	1313172.YM304_00070	0.0	1264.0	COG0188@1|root,COG0188@2|Bacteria,2GJ2Q@201174|Actinobacteria,4CMSQ@84992|Acidimicrobiia	84992|Acidimicrobiia	L	DNA Topoisomerase IV	-	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
REGS3_k127_8362865_1	1313172.YM304_00060	0.0	1023.0	COG0187@1|root,COG0187@2|Bacteria,2GKGP@201174|Actinobacteria,4CMQZ@84992|Acidimicrobiia	84992|Acidimicrobiia	L	TopoisomeraseII	-	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
REGS3_k127_8362865_22	1313172.YM304_00050	8.146e-20	97.0	COG5512@1|root,COG5512@2|Bacteria	2|Bacteria	L	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DUF721
REGS3_k127_8362865_6	1313172.YM304_00030	2.474e-147	474.0	COG1195@1|root,COG1195@2|Bacteria,2GJCS@201174|Actinobacteria,4CN4M@84992|Acidimicrobiia	84992|Acidimicrobiia	L	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP	recF	-	-	ko:K03629	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	SMC_N
REGS3_k127_8362865_3	1313172.YM304_00020	1.157e-157	505.0	COG0592@1|root,COG0592@2|Bacteria,2GJK3@201174|Actinobacteria,4CN18@84992|Acidimicrobiia	84992|Acidimicrobiia	L	DNA polymerase III beta subunit	dnaN	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
REGS3_k127_8362865_2	1313172.YM304_00010	6.72e-190	603.0	COG0593@1|root,COG0593@2|Bacteria,2GJKI@201174|Actinobacteria,4CMQT@84992|Acidimicrobiia	84992|Acidimicrobiia	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	-	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
REGS3_k127_8362865_24	525909.Afer_2038	1.549e-13	73.0	COG0230@1|root,COG0230@2|Bacteria,2GQFY@201174|Actinobacteria,4CP4C@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Ribosomal protein L34	rpmH	-	-	ko:K02914	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L34
REGS3_k127_8362865_25	1298863.AUEP01000009_gene231	3.609e-08	62.0	COG0594@1|root,COG0594@2|Bacteria,2GR42@201174|Actinobacteria,4DSDD@85009|Propionibacteriales	201174|Actinobacteria	J	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme	rnpA	GO:0008150,GO:0040007	3.1.26.5	ko:K03536	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_P
REGS3_k127_8362865_19	1313172.YM304_42890	4.619e-26	113.0	COG0759@1|root,COG0759@2|Bacteria,2HH1R@201174|Actinobacteria,4CP20@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Could be involved in insertion of integral membrane proteins into the membrane	-	-	-	ko:K08998	-	-	-	-	ko00000	-	-	-	Haemolytic
REGS3_k127_8362865_10	1313172.YM304_42880	1.246e-90	310.0	COG0706@1|root,COG0706@2|Bacteria,2GJBU@201174|Actinobacteria,4CN42@84992|Acidimicrobiia	84992|Acidimicrobiia	U	60Kd inner membrane protein	-	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP
REGS3_k127_8362865_12	1313172.YM304_42870	2.153e-76	264.0	COG1847@1|root,COG1847@2|Bacteria,2GPZK@201174|Actinobacteria,4CN3J@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Putative single-stranded nucleic acids-binding domain	-	-	-	ko:K06346	-	-	-	-	ko00000	-	-	-	Jag_N,R3H
REGS3_k127_8362865_20	1313172.YM304_42860	1.243e-24	111.0	COG0357@1|root,COG0357@2|Bacteria,2HGHA@201174|Actinobacteria,4CNEN@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Ribosomal RNA small subunit methyltransferase G	rsmG	-	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB
REGS3_k127_8362865_7	1313172.YM304_42850	1.312e-137	441.0	COG1192@1|root,COG1192@2|Bacteria,2GMU7@201174|Actinobacteria,4CMSR@84992|Acidimicrobiia	84992|Acidimicrobiia	D	Cellulose biosynthesis protein BcsQ	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
REGS3_k127_8362865_8	1313172.YM304_42840	4.958e-125	407.0	COG1475@1|root,COG1475@2|Bacteria,2GNRN@201174|Actinobacteria,4CMXK@84992|Acidimicrobiia	84992|Acidimicrobiia	K	ParB-like nuclease domain	-	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
REGS3_k127_8362865_13	1313172.YM304_42830	4.294e-63	229.0	COG0860@1|root,COG3409@1|root,COG0860@2|Bacteria,COG3409@2|Bacteria,2HG9Y@201174|Actinobacteria,4CN8M@84992|Acidimicrobiia	84992|Acidimicrobiia	M	Putative peptidoglycan binding domain	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	PG_binding_1
REGS3_k127_8362865_27	1442599.JAAN01000072_gene825	0.0008616	51.0	COG1876@1|root,COG3409@1|root,COG1876@2|Bacteria,COG3409@2|Bacteria,1NAYN@1224|Proteobacteria,1SYR5@1236|Gammaproteobacteria,1XCSN@135614|Xanthomonadales	135614|Xanthomonadales	M	D-alanyl-D-alanine carboxypeptidase	-	-	-	ko:K17733	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M15_4
REGS3_k127_8362865_17	1172186.KB911463_gene3730	1.252e-35	138.0	COG3118@1|root,COG3118@2|Bacteria,2IQ9T@201174|Actinobacteria,239Y7@1762|Mycobacteriaceae	201174|Actinobacteria	O	belongs to the thioredoxin family	trxC	GO:0003674,GO:0003824,GO:0004791,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009055,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0015037,GO:0015038,GO:0016020,GO:0016209,GO:0016491,GO:0016651,GO:0016657,GO:0016667,GO:0016668,GO:0016671,GO:0019725,GO:0022900,GO:0030312,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0047134,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0071944,GO:0080007,GO:0097237,GO:0098754,GO:0098869,GO:1990748	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
REGS3_k127_8362865_4	1313172.YM304_42800	1.886e-148	475.0	COG0492@1|root,COG0492@2|Bacteria,2GKD2@201174|Actinobacteria,4CMUE@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Pyridine nucleotide-disulphide oxidoreductase	trxB	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
REGS3_k127_8362865_14	1313172.YM304_42760	2.428e-60	214.0	COG1595@1|root,COG1595@2|Bacteria,2GJMX@201174|Actinobacteria	201174|Actinobacteria	K	belongs to the sigma-70 factor family, ECF subfamily	sigW	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
REGS3_k127_8362865_5	1313172.YM304_42750	1.241e-147	488.0	COG0515@1|root,COG0515@2|Bacteria,2GJ1J@201174|Actinobacteria,4CMUZ@84992|Acidimicrobiia	201174|Actinobacteria	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
REGS3_k127_8362865_9	1313172.YM304_42740	1.856e-113	372.0	COG1307@1|root,COG1307@2|Bacteria,2GIUV@201174|Actinobacteria,4CN2K@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Uncharacterised protein, DegV family COG1307	-	-	-	-	-	-	-	-	-	-	-	-	DegV
REGS3_k127_8362865_23	1313172.YM304_42730	4.267e-16	82.0	2B0G0@1|root,31STG@2|Bacteria,2HGDS@201174|Actinobacteria,4CNCA@84992|Acidimicrobiia	84992|Acidimicrobiia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_8551912_1	1380390.JIAT01000010_gene3517	1.966e-129	423.0	COG1171@1|root,COG1171@2|Bacteria,2GJAG@201174|Actinobacteria,4CS00@84995|Rubrobacteria	84995|Rubrobacteria	E	Pyridoxal-phosphate dependent enzyme	-	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
REGS3_k127_8551912_3	1370125.AUWT01000017_gene2445	1.67e-41	161.0	COG0518@1|root,COG0518@2|Bacteria,2GNA6@201174|Actinobacteria,234I4@1762|Mycobacteriaceae	201174|Actinobacteria	F	glutamine amidotransferase	-	-	-	-	-	-	-	-	-	-	-	-	GATase
REGS3_k127_8551912_0	1089545.KB913037_gene4233	9.273e-142	468.0	COG0531@1|root,COG0531@2|Bacteria,2GIWQ@201174|Actinobacteria,4DYNN@85010|Pseudonocardiales	201174|Actinobacteria	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
REGS3_k127_8551912_2	1380390.JIAT01000010_gene4683	6.778e-42	162.0	COG3576@1|root,COG3576@2|Bacteria,2I46F@201174|Actinobacteria	201174|Actinobacteria	S	pyridoxamine 5-phosphate	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
REGS3_k127_8551912_4	1283299.AUKG01000002_gene4310	2.812e-28	116.0	COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,2GNCW@201174|Actinobacteria,4CPSG@84995|Rubrobacteria	84995|Rubrobacteria	E	FAD dependent oxidoreductase central domain	-	-	-	-	-	-	-	-	-	-	-	-	DAO,FAO_M,GCV_T,GCV_T_C
REGS3_k127_886606_8	1429916.X566_17870	8.844e-19	92.0	COG1232@1|root,COG1232@2|Bacteria	2|Bacteria	H	protoporphyrinogen oxidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
REGS3_k127_886606_4	522373.Smlt3223	6.876e-64	230.0	COG1595@1|root,COG1595@2|Bacteria,1MXVA@1224|Proteobacteria,1S2J2@1236|Gammaproteobacteria,1X5VZ@135614|Xanthomonadales	135614|Xanthomonadales	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
REGS3_k127_886606_7	1453496.AT03_07135	3.057e-31	134.0	COG3221@1|root,COG3221@2|Bacteria,1R6YE@1224|Proteobacteria,1RY4D@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	ABC-type phosphate phosphonate transport system periplasmic component	-	-	-	-	-	-	-	-	-	-	-	-	Phosphonate-bd
REGS3_k127_886606_6	666509.RCA23_c22080	4.224e-55	204.0	COG3239@1|root,COG3239@2|Bacteria,1MXA8@1224|Proteobacteria,2TUQG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Fatty acid desaturase	-	-	-	-	-	-	-	-	-	-	-	-	FA_desaturase
REGS3_k127_886606_2	331869.BAL199_22059	8.352e-77	269.0	COG1476@1|root,COG1476@2|Bacteria,1NQ7T@1224|Proteobacteria,2TUQU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
REGS3_k127_886606_5	1229780.BN381_150001	7.496e-57	216.0	COG1807@1|root,COG1807@2|Bacteria,2IITJ@201174|Actinobacteria	2|Bacteria	M	Evidence 5 No homology to any previously reported sequences	-	-	-	ko:K14340	-	-	-	-	ko00000,ko01000,ko01003	-	-	-	PMT_2
REGS3_k127_886606_1	1380394.JADL01000010_gene4325	1.948e-224	706.0	COG5598@1|root,COG5598@2|Bacteria,1MX73@1224|Proteobacteria,2TS1M@28211|Alphaproteobacteria,2JVS6@204441|Rhodospirillales	204441|Rhodospirillales	H	Trimethylamine methyltransferase (MTTB)	-	-	-	-	-	-	-	-	-	-	-	-	MTTB
REGS3_k127_886606_0	744980.TRICHSKD4_3309	0.0	1115.0	COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,1MUXJ@1224|Proteobacteria,2TRGS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Belongs to the GcvT family	-	-	1.5.8.4	ko:K00315	ko00260,ko01100,map00260,map01100	-	R01565	RC00181	ko00000,ko00001,ko01000	-	-	-	DAO,FAO_M,GCV_T,GCV_T_C
REGS3_k127_886606_3	34007.IT40_22610	7.052e-73	274.0	COG0404@1|root,COG0446@1|root,COG0404@2|Bacteria,COG0446@2|Bacteria,1MVEK@1224|Proteobacteria,2TTD7@28211|Alphaproteobacteria,2PYBZ@265|Paracoccus	28211|Alphaproteobacteria	H	Belongs to the GcvT family	-	-	1.5.3.1	ko:K00302	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	Fer2_4,GCV_T,GCV_T_C,Pyr_redox_2
REGS3_k127_901602_17	351607.Acel_0442	9.652e-20	102.0	COG5305@1|root,COG5305@2|Bacteria,2IDAQ@201174|Actinobacteria,4EW9F@85013|Frankiales	201174|Actinobacteria	S	Predicted membrane protein (DUF2142)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2142
REGS3_k127_901602_11	1206731.BAGB01000068_gene7014	5.286e-61	217.0	COG0778@1|root,COG0778@2|Bacteria,2GKG5@201174|Actinobacteria,4G04D@85025|Nocardiaceae	201174|Actinobacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
REGS3_k127_901602_14	1463901.JOIY01000018_gene6592	4.492e-49	183.0	COG2318@1|root,COG2318@2|Bacteria,2HUJD@201174|Actinobacteria	201174|Actinobacteria	K	Protein of unknown function (DUF664)	-	-	-	-	-	-	-	-	-	-	-	-	DUF664
REGS3_k127_901602_19	1229780.BN381_100022	8.744e-07	62.0	COG3764@1|root,COG3764@2|Bacteria	2|Bacteria	M	Sortase family	-	-	3.4.22.70	ko:K07284	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Sortase
REGS3_k127_901602_15	1313172.YM304_12900	2.576e-47	190.0	COG5184@1|root,COG5184@2|Bacteria,2I4Y5@201174|Actinobacteria	201174|Actinobacteria	DZ	regulator of chromosome condensation, RCC1	-	-	-	-	-	-	-	-	-	-	-	-	RCC1
REGS3_k127_901602_6	1313172.YM304_20360	7.665e-138	446.0	COG0337@1|root,COG0337@2|Bacteria,2GIUZ@201174|Actinobacteria,4CMXJ@84992|Acidimicrobiia	84992|Acidimicrobiia	H	3-dehydroquinate synthase	aroB	-	-	ko:K16020	ko01051,ko01130,map01051,map01130	-	R06592	RC00847	ko00000,ko00001	-	-	-	DHQ_synthase
REGS3_k127_901602_12	1313172.YM304_20350	9.698e-55	197.0	COG0703@1|root,COG0703@2|Bacteria,2GRFW@201174|Actinobacteria,4CNCU@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	aroK	-	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	SKI
REGS3_k127_901602_3	1313172.YM304_20340	2.457e-194	612.0	COG0082@1|root,COG0082@2|Bacteria,2GJJN@201174|Actinobacteria,4CMPX@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	-	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
REGS3_k127_901602_10	1313172.YM304_20320	5.184e-82	287.0	COG0169@1|root,COG0169@2|Bacteria,2GPQQ@201174|Actinobacteria,4CN43@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	-	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_DH,Shikimate_dh_N
REGS3_k127_901602_7	1313172.YM304_20310	9.235e-121	402.0	COG1559@1|root,COG1559@2|Bacteria,2GKGQ@201174|Actinobacteria,4CN7T@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
REGS3_k127_901602_16	1313172.YM304_20300	6.765e-39	150.0	COG0816@1|root,COG0816@2|Bacteria,2HGE6@201174|Actinobacteria,4CNCG@84992|Acidimicrobiia	84992|Acidimicrobiia	L	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA	-	-	-	ko:K07447	-	-	-	-	ko00000,ko01000	-	-	-	RuvX
REGS3_k127_901602_1	913325.N799_08995	1.074e-227	733.0	COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,1RMWZ@1236|Gammaproteobacteria,1X3MQ@135614|Xanthomonadales	135614|Xanthomonadales	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
REGS3_k127_901602_9	1313172.YM304_20280	2.714e-95	319.0	28IRH@1|root,2Z8QX@2|Bacteria,2GJW6@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_901602_5	1313172.YM304_04410	2.014e-148	477.0	COG3173@1|root,COG3173@2|Bacteria	2|Bacteria	S	very-long-chain-acyl-CoA dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	APH
REGS3_k127_901602_2	1382359.JIAL01000001_gene577	3.261e-205	656.0	COG1217@1|root,COG1217@2|Bacteria,3Y33Q@57723|Acidobacteria,2JIIC@204432|Acidobacteriia	204432|Acidobacteriia	T	GTP-binding protein TypA	-	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
REGS3_k127_901602_4	1313172.YM304_26900	2.628e-170	546.0	COG1013@1|root,COG1013@2|Bacteria,2GMI5@201174|Actinobacteria	201174|Actinobacteria	C	Ferredoxin oxidoreductase	korB	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
REGS3_k127_901602_0	1288083.AUKR01000012_gene595	1.947e-253	797.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,2GKXV@201174|Actinobacteria	201174|Actinobacteria	C	Ferredoxin oxidoreductase	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
REGS3_k127_901602_8	1146883.BLASA_4994	3.458e-115	378.0	COG0366@1|root,COG0366@2|Bacteria,2GKS4@201174|Actinobacteria,4ERW2@85013|Frankiales	201174|Actinobacteria	G	SMART alpha amylase, catalytic sub domain	-	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	Alpha-amylase,DUF3459
REGS3_k127_901608_2	1122138.AQUZ01000001_gene1795	1.655e-86	299.0	COG1404@1|root,COG1404@2|Bacteria,2GK3D@201174|Actinobacteria,4DSSQ@85009|Propionibacteriales	201174|Actinobacteria	O	PA domain	-	-	-	-	-	-	-	-	-	-	-	-	Inhibitor_I9,PA,Peptidase_S8,fn3_5
REGS3_k127_901608_1	1313172.YM304_29050	1.361e-93	315.0	COG0846@1|root,COG0846@2|Bacteria,2GJI3@201174|Actinobacteria,4CNTU@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Sir2 family	-	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
REGS3_k127_901608_0	1313172.YM304_29030	1.252e-194	613.0	COG0476@1|root,COG0607@1|root,COG0476@2|Bacteria,COG0607@2|Bacteria,2GJB6@201174|Actinobacteria,4CMRS@84992|Acidimicrobiia	84992|Acidimicrobiia	HP	ThiF family	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese,ThiF
REGS3_k127_905928_1	1313172.YM304_25510	1.717e-204	642.0	COG1960@1|root,COG1960@2|Bacteria,2GKVN@201174|Actinobacteria,4CNFE@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Acyl-CoA dehydrogenase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
REGS3_k127_905928_5	1313172.YM304_25480	8.15e-31	132.0	COG2912@1|root,COG2912@2|Bacteria,2GMER@201174|Actinobacteria	201174|Actinobacteria	S	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	TPR_9,Transglut_core2
REGS3_k127_905928_0	1313172.YM304_25470	2.989e-263	818.0	COG0318@1|root,COG0318@2|Bacteria,2GJAA@201174|Actinobacteria,4CP51@84992|Acidimicrobiia	201174|Actinobacteria	IQ	Protein synonym acyl-CoA synthetase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
REGS3_k127_905928_2	471852.Tcur_0327	6.801e-167	537.0	COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria,4EHQQ@85012|Streptosporangiales	201174|Actinobacteria	C	Aldehyde dehydrogenase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldedh
REGS3_k127_905928_4	512565.AMIS_66500	4.648e-73	253.0	COG0584@1|root,COG0584@2|Bacteria,2GJ5W@201174|Actinobacteria,4DB2J@85008|Micromonosporales	201174|Actinobacteria	C	glycerophosphoryl diester phosphodiesterase	glpQ2	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
REGS3_k127_905928_3	2074.JNYD01000031_gene6584	6.461e-106	351.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4DZW9@85010|Pseudonocardiales	201174|Actinobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	-	ko:K16029	ko01051,ko01052,map01051,map01052	-	-	-	ko00000,ko00001	-	-	-	AMP-binding,AMP-binding_C
REGS3_k127_908505_11	1313172.YM304_13400	3.419e-11	72.0	COG1403@1|root,COG1403@2|Bacteria	2|Bacteria	V	endonuclease activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
REGS3_k127_908505_6	1394178.AWOO02000017_gene6702	3.383e-65	227.0	COG1765@1|root,COG1765@2|Bacteria,2IG8A@201174|Actinobacteria,4EKV5@85012|Streptosporangiales	201174|Actinobacteria	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
REGS3_k127_908505_9	1122182.KB903814_gene3109	5.166e-31	126.0	COG0346@1|root,COG0346@2|Bacteria,2IM78@201174|Actinobacteria,4DK2V@85008|Micromonosporales	201174|Actinobacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_908505_2	1123320.KB889704_gene9381	8.064e-111	376.0	COG0183@1|root,COG0183@2|Bacteria	2|Bacteria	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	-
REGS3_k127_908505_4	1206731.BAGB01000006_gene4032	1.262e-90	306.0	COG1024@1|root,COG1024@2|Bacteria,2GKJ6@201174|Actinobacteria,4FUTM@85025|Nocardiaceae	201174|Actinobacteria	I	enoyl-CoA hydratase	echA19	GO:0003674,GO:0003824,GO:0004300,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
REGS3_k127_908505_0	1313172.YM304_15730	3.929e-193	627.0	COG3420@1|root,COG3669@1|root,COG3420@2|Bacteria,COG3669@2|Bacteria,2HUEI@201174|Actinobacteria	201174|Actinobacteria	G	Alpha-L-fucosidase	-	-	3.2.1.51	ko:K01206	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04147	-	GH29	-	Alpha_L_fucos
REGS3_k127_908505_7	526225.Gobs_1045	4.932e-53	201.0	COG1752@1|root,COG1752@2|Bacteria,2IB0F@201174|Actinobacteria,4ET56@85013|Frankiales	201174|Actinobacteria	S	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
REGS3_k127_908505_5	28444.JODQ01000010_gene3087	3.555e-68	243.0	COG1606@1|root,COG1606@2|Bacteria,2GPA1@201174|Actinobacteria	201174|Actinobacteria	S	PFAM ExsB family protein	-	-	-	ko:K06864	-	-	-	-	ko00000	-	-	-	Asn_synthase,NAD_synthase,QueC
REGS3_k127_908505_1	1313172.YM304_15740	2.124e-144	465.0	COG2141@1|root,COG2141@2|Bacteria,2GIY3@201174|Actinobacteria,4CMWM@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
REGS3_k127_908505_10	1282876.BAOK01000001_gene3294	1.563e-12	74.0	COG1359@1|root,COG1359@2|Bacteria,1NGPW@1224|Proteobacteria,2UFWZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
REGS3_k127_908505_3	1313172.YM304_26570	2.334e-94	322.0	COG1680@1|root,COG1680@2|Bacteria,2GJJB@201174|Actinobacteria	201174|Actinobacteria	V	COG1680 Beta-lactamase class C and other penicillin binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
REGS3_k127_915380_7	1280952.HJA_10815	2.835e-105	350.0	COG0654@1|root,COG0654@2|Bacteria,1R7NX@1224|Proteobacteria,2UN05@28211|Alphaproteobacteria,43Z1V@69657|Hyphomonadaceae	28211|Alphaproteobacteria	CH	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
REGS3_k127_915380_6	402881.Plav_3234	1.862e-121	402.0	COG0019@1|root,COG0019@2|Bacteria,1MZ7Y@1224|Proteobacteria,2TSKB@28211|Alphaproteobacteria,1JNB0@119043|Rhodobiaceae	28211|Alphaproteobacteria	E	Belongs to the Orn Lys Arg decarboxylase class-II family	speF	-	4.1.1.17	ko:K01581	ko00330,ko00480,ko01100,ko01110,ko01130,map00330,map00480,map01100,map01110,map01130	M00134	R00670	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
REGS3_k127_915380_11	42565.FP66_05210	2.328e-40	160.0	COG1670@1|root,COG1670@2|Bacteria,1RB1I@1224|Proteobacteria,1S7ZE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Domain of unknown function (DUF4202)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4202
REGS3_k127_915380_5	671143.DAMO_1031	3.144e-132	443.0	COG0155@1|root,COG0155@2|Bacteria,2NPHB@2323|unclassified Bacteria	2|Bacteria	P	Nitrite and sulphite reductase 4Fe-4S domain	cysI	-	1.7.1.15,1.7.7.1,1.8.1.2,1.8.7.1	ko:K00362,ko:K00366,ko:K00381,ko:K00392	ko00910,ko00920,ko01100,ko01120,map00910,map00920,map01100,map01120	M00176,M00530,M00531	R00787,R00790,R00858,R00859,R03600	RC00065,RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	HEPN,NIR_SIR,NIR_SIR_ferr
REGS3_k127_915380_1	2002.JOEQ01000022_gene6956	4.302e-255	797.0	COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4EHPN@85012|Streptosporangiales	201174|Actinobacteria	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
REGS3_k127_915380_0	1122138.AQUZ01000005_gene2614	3.787e-261	822.0	COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4DN2U@85009|Propionibacteriales	201174|Actinobacteria	V	ABC transporter transmembrane region	yfiC	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
REGS3_k127_915380_3	1283299.AUKG01000006_gene766	1.574e-200	638.0	COG1020@1|root,COG1020@2|Bacteria,2GKGU@201174|Actinobacteria	201174|Actinobacteria	I	Belongs to the long-chain O-acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	DUF1298,WES_acyltransf
REGS3_k127_915380_4	1120949.KB903294_gene4013	3.934e-149	494.0	COG5001@1|root,COG5001@2|Bacteria,2GIZF@201174|Actinobacteria	201174|Actinobacteria	T	signal transduction protein containing a membrane domain an EAL and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF
REGS3_k127_915380_2	1313172.YM304_17830	5.767e-209	676.0	COG5001@1|root,COG5001@2|Bacteria,2GIZF@201174|Actinobacteria,4CNQD@84992|Acidimicrobiia	84992|Acidimicrobiia	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF
REGS3_k127_915380_10	1313172.YM304_17840	3.141e-49	178.0	COG3153@1|root,COG3153@2|Bacteria,2IS85@201174|Actinobacteria	201174|Actinobacteria	S	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_932725_17	1440774.Y900_008670	2.456e-13	81.0	COG1295@1|root,COG1295@2|Bacteria,2GKV0@201174|Actinobacteria,2371H@1762|Mycobacteriaceae	201174|Actinobacteria	S	ribonuclease BN	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_932725_7	1123320.KB889585_gene1770	9.118e-125	409.0	COG2141@1|root,COG2141@2|Bacteria,2IB10@201174|Actinobacteria	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
REGS3_k127_932725_2	1449353.JQMQ01000005_gene5516	2.712e-169	540.0	COG1804@1|root,COG1804@2|Bacteria,2GKNX@201174|Actinobacteria,2NGFF@228398|Streptacidiphilus	201174|Actinobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
REGS3_k127_932725_6	298655.KI912266_gene5537	2.742e-135	441.0	COG2141@1|root,COG2141@2|Bacteria,2GKP1@201174|Actinobacteria	201174|Actinobacteria	C	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
REGS3_k127_932725_9	1229780.BN381_350101	2.041e-118	396.0	COG1960@1|root,COG1960@2|Bacteria,2GJDT@201174|Actinobacteria	201174|Actinobacteria	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
REGS3_k127_932725_14	258052.JNYV01000002_gene777	3.294e-90	308.0	COG1545@1|root,COG1545@2|Bacteria,2GM2A@201174|Actinobacteria	201174|Actinobacteria	I	nucleic-acid-binding protein containing a Zn-ribbon	-	-	-	-	-	-	-	-	-	-	-	-	DUF35_N,MaoC_dehydrat_N,OB_aCoA_assoc
REGS3_k127_932725_13	1206726.BAFV01000006_gene313	5.877e-100	343.0	COG1960@1|root,COG1960@2|Bacteria,2GITF@201174|Actinobacteria,4FXAS@85025|Nocardiaceae	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
REGS3_k127_932725_16	1123320.KB889730_gene5894	4.895e-56	199.0	COG2030@1|root,COG2030@2|Bacteria,2IHT0@201174|Actinobacteria	201174|Actinobacteria	I	dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
REGS3_k127_932725_1	882083.SacmaDRAFT_2066	5.293e-179	574.0	COG0183@1|root,COG0183@2|Bacteria,2GKFR@201174|Actinobacteria,4E22C@85010|Pseudonocardiales	201174|Actinobacteria	I	lipid-transfer protein	-	-	-	-	-	-	-	-	-	-	-	-	Thiolase_N
REGS3_k127_932725_8	298654.FraEuI1c_5098	9.646e-120	400.0	COG2124@1|root,COG2124@2|Bacteria,2GKCG@201174|Actinobacteria	201174|Actinobacteria	Q	cytochrome P450	-	-	1.14.13.141	ko:K15981	ko00984,ko01120,map00984,map01120	-	R09859,R11357	RC01216,RC03368	ko00000,ko00001,ko00199,ko01000	-	-	-	p450
REGS3_k127_932725_15	1408452.JAGZ01000001_gene3751	1.275e-87	303.0	COG2124@1|root,COG2124@2|Bacteria,2GJ8V@201174|Actinobacteria,235I4@1762|Mycobacteriaceae	201174|Actinobacteria	Q	cytochrome p450	-	-	-	-	-	-	-	-	-	-	-	-	p450
REGS3_k127_932725_10	35754.JNYJ01000003_gene6578	2.504e-116	382.0	COG1028@1|root,COG1028@2|Bacteria,2GN3D@201174|Actinobacteria,4DAS8@85008|Micromonosporales	201174|Actinobacteria	IQ	KR domain	-	GO:0003674,GO:0003824,GO:0004303,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0006066,GO:0006629,GO:0007568,GO:0008150,GO:0008152,GO:0008202,GO:0008203,GO:0009719,GO:0009725,GO:0009987,GO:0010033,GO:0014070,GO:0016125,GO:0016229,GO:0016491,GO:0016614,GO:0016616,GO:0016829,GO:0016835,GO:0016836,GO:0018812,GO:0030283,GO:0032502,GO:0033764,GO:0033993,GO:0042221,GO:0042493,GO:0042579,GO:0042802,GO:0042803,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0044594,GO:0046983,GO:0048545,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071310,GO:0071407,GO:0071704,GO:1901360,GO:1901615,GO:1902652	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
REGS3_k127_932725_3	1463854.JOHT01000006_gene6752	2.256e-161	528.0	COG1960@1|root,COG1960@2|Bacteria,2GM1Q@201174|Actinobacteria	201174|Actinobacteria	I	acyl-CoA dehydrogenase	fadE30	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
REGS3_k127_932725_11	1476876.JOJO01000015_gene6119	8.667e-114	374.0	COG1028@1|root,COG1028@2|Bacteria,2GN6U@201174|Actinobacteria	201174|Actinobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
REGS3_k127_932725_4	1429046.RR21198_2202	2.07e-154	499.0	COG1960@1|root,COG1960@2|Bacteria,2GIXS@201174|Actinobacteria,4FUI9@85025|Nocardiaceae	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, middle domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
REGS3_k127_932725_12	1150599.MPHLEI_09884	1.526e-107	356.0	COG2141@1|root,COG2141@2|Bacteria,2GJT1@201174|Actinobacteria,2330F@1762|Mycobacteriaceae	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
REGS3_k127_932725_5	1313172.YM304_32930	2.327e-140	455.0	COG1680@1|root,COG1680@2|Bacteria,2GJJB@201174|Actinobacteria	201174|Actinobacteria	V	COG1680 Beta-lactamase class C and other penicillin binding proteins	lipP	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
REGS3_k127_932725_0	298655.KI912266_gene5536	6.62e-183	587.0	COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria	201174|Actinobacteria	C	Belongs to the aldehyde dehydrogenase family	aldA_1	-	1.2.1.3,1.2.1.39	ko:K00128,ko:K00146	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00360,ko00380,ko00410,ko00561,ko00620,ko00625,ko00643,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00360,map00380,map00410,map00561,map00620,map00625,map00643,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02536,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
REGS3_k127_954582_9	1313172.YM304_11430	2.499e-79	265.0	COG0028@1|root,COG0028@2|Bacteria,2GKU4@201174|Actinobacteria,4CMWQ@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Thiamine pyrophosphate enzyme, central domain	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
REGS3_k127_954582_1	1313172.YM304_22210	2.14e-275	858.0	COG0511@1|root,COG4799@1|root,COG0511@2|Bacteria,COG4799@2|Bacteria,2I46V@201174|Actinobacteria	201174|Actinobacteria	I	PFAM carboxyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl,Carboxyl_trans
REGS3_k127_954582_2	1120949.KB903294_gene3619	2.976e-230	720.0	COG1350@1|root,COG1350@2|Bacteria,2GP7D@201174|Actinobacteria,4DBN0@85008|Micromonosporales	201174|Actinobacteria	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB2	-	4.2.1.20	ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
REGS3_k127_954582_4	861299.J421_3601	1.523e-199	630.0	COG1260@1|root,COG1260@2|Bacteria,1ZT2X@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Myo-inositol-1-phosphate synthase	-	-	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth,NAD_binding_5
REGS3_k127_954582_6	585531.HMPREF0063_11656	1.741e-123	405.0	COG1171@1|root,COG1171@2|Bacteria,2I8UC@201174|Actinobacteria,4DR0H@85009|Propionibacteriales	201174|Actinobacteria	E	Pyridoxal-phosphate dependent enzyme	-	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
REGS3_k127_954582_14	869213.JCM21142_104516	1.35e-24	110.0	COG0212@1|root,COG0212@2|Bacteria,4NQRG@976|Bacteroidetes	976|Bacteroidetes	H	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family	fthC	-	6.3.3.2	ko:K01934	ko00670,ko01100,map00670,map01100	-	R02301	RC00183	ko00000,ko00001,ko01000	-	-	-	5-FTHF_cyc-lig
REGS3_k127_954582_11	1313172.YM304_33610	7.152e-61	214.0	COG1853@1|root,COG1853@2|Bacteria,2GPJS@201174|Actinobacteria	201174|Actinobacteria	K	PFAM flavin reductase domain protein, FMN-binding	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
REGS3_k127_954582_13	1313172.YM304_33620	4.423e-28	122.0	2E6D0@1|root,3310N@2|Bacteria,2HGH7@201174|Actinobacteria,4CNEK@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Protein of unknown function (DUF3054)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3054
REGS3_k127_954582_3	644283.Micau_1247	6.503e-209	662.0	COG0028@1|root,COG0028@2|Bacteria,2GM6Y@201174|Actinobacteria,4DA3Q@85008|Micromonosporales	201174|Actinobacteria	EH	Belongs to the TPP enzyme family	ilvG	GO:0000287,GO:0003674,GO:0003824,GO:0003984,GO:0005488,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0019842,GO:0030976,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901681	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1820	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
REGS3_k127_954582_0	1313172.YM304_33670	2.831e-299	925.0	COG0129@1|root,COG0129@2|Bacteria,2GJIJ@201174|Actinobacteria,4CMQ6@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Dehydratase family	ilvD	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
REGS3_k127_954582_8	1054213.HMPREF9946_04408	2.542e-84	291.0	COG1171@1|root,COG1171@2|Bacteria,1MW2Q@1224|Proteobacteria,2TTP9@28211|Alphaproteobacteria,2JW6N@204441|Rhodospirillales	204441|Rhodospirillales	E	Pyridoxal-phosphate dependent enzyme	-	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
REGS3_k127_954582_7	1123320.KB889697_gene8996	2.747e-110	364.0	COG2159@1|root,COG2159@2|Bacteria,2GMQY@201174|Actinobacteria	201174|Actinobacteria	S	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
REGS3_k127_954582_12	1077972.ARGLB_051_00230	2.311e-49	184.0	COG2606@1|root,COG2606@2|Bacteria,2IHS8@201174|Actinobacteria,1W9EP@1268|Micrococcaceae	201174|Actinobacteria	S	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily	ybaK	-	-	ko:K03976	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_edit
REGS3_k127_954582_10	1313172.YM304_33930	9.811e-69	245.0	COG0501@1|root,COG0501@2|Bacteria,2GTHQ@201174|Actinobacteria	201174|Actinobacteria	O	Peptidase family M48	-	-	3.4.24.84	ko:K06013	ko00900,ko01130,map00900,map01130	-	R09845	RC00141	ko00000,ko00001,ko01000,ko01002,ko04147	-	-	-	Peptidase_M48
REGS3_k127_954582_5	1313172.YM304_33920	5.26e-146	481.0	COG0457@1|root,COG3437@1|root,COG0457@2|Bacteria,COG3437@2|Bacteria,2I49F@201174|Actinobacteria,4CP5F@84992|Acidimicrobiia	84992|Acidimicrobiia	KT	HD domain	-	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	-
REGS3_k127_957459_3	1229780.BN381_130043	5.455e-158	508.0	COG0519@1|root,COG0519@2|Bacteria,2GM09@201174|Actinobacteria,3UWCD@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	F	Catalyzes the synthesis of GMP from XMP	guaA	GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
REGS3_k127_957459_5	365528.KB891251_gene5794	2.641e-127	414.0	COG0596@1|root,COG0596@2|Bacteria,2GJCT@201174|Actinobacteria	201174|Actinobacteria	F	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
REGS3_k127_957459_1	1313172.YM304_35320	6.807e-208	656.0	COG0076@1|root,COG0076@2|Bacteria,2GK3J@201174|Actinobacteria,4CN9X@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Pyridoxal-dependent decarboxylase conserved domain	-	-	4.1.1.105,4.1.1.28	ko:K01593	ko00350,ko00360,ko00380,ko00901,ko00950,ko00965,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00350,map00360,map00380,map00901,map00950,map00965,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00037,M00042	R00685,R00699,R00736,R02080,R02701,R04909	RC00299	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyridoxal_deC
REGS3_k127_957459_13	1121946.AUAX01000003_gene1545	3.918e-12	74.0	COG5479@1|root,COG5479@2|Bacteria,2IFCZ@201174|Actinobacteria,4DCSZ@85008|Micromonosporales	201174|Actinobacteria	M	Prokaryotic phospholipase A2	-	-	-	-	-	-	-	-	-	-	-	-	Phospholip_A2_3
REGS3_k127_957459_6	1313172.YM304_35360	4.855e-65	230.0	COG0494@1|root,COG0494@2|Bacteria	2|Bacteria	L	nUDIX hydrolase	nudL	GO:0003674,GO:0003824,GO:0016787,GO:0016817,GO:0016818	-	-	-	-	-	-	-	-	-	-	NUDIX
REGS3_k127_957459_0	1313172.YM304_35380	5.922e-278	862.0	COG0459@1|root,COG0459@2|Bacteria,2GKC9@201174|Actinobacteria,4CMU0@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	-	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
REGS3_k127_957459_11	1273125.Rrhod_0005	7.321e-38	145.0	COG0234@1|root,COG0234@2|Bacteria,2IKTH@201174|Actinobacteria,4G204@85025|Nocardiaceae	201174|Actinobacteria	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0019899,GO:0030312,GO:0031323,GO:0031326,GO:0033554,GO:0034605,GO:0035375,GO:0035966,GO:0040007,GO:0042221,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0046872,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065007,GO:0071944,GO:0080090,GO:1903506,GO:2000112,GO:2001141	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
REGS3_k127_957459_10	234267.Acid_1082	2.587e-42	165.0	COG0424@1|root,COG0424@2|Bacteria,3Y4ZU@57723|Acidobacteria	57723|Acidobacteria	D	Maf-like protein	-	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
REGS3_k127_957459_2	1313172.YM304_08980	5.885e-159	509.0	COG0042@1|root,COG0042@2|Bacteria,2GJ8I@201174|Actinobacteria	201174|Actinobacteria	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	dus	GO:0008150,GO:0010565,GO:0019216,GO:0019217,GO:0019222,GO:0031323,GO:0050789,GO:0050794,GO:0062012,GO:0065007,GO:0080090	-	-	-	-	-	-	-	-	-	-	Dus
REGS3_k127_957459_9	1449351.RISW2_10670	1.519e-48	189.0	COG0116@1|root,COG0116@2|Bacteria,1MUQM@1224|Proteobacteria,2TSWI@28211|Alphaproteobacteria,4KKQ3@93682|Roseivivax	28211|Alphaproteobacteria	L	Putative RNA methylase family UPF0020	rlmL	-	2.1.1.173,2.1.1.264	ko:K07444,ko:K12297	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	THUMP,UPF0020
REGS3_k127_957459_4	1313172.YM304_08960	2.943e-154	494.0	COG0533@1|root,COG0533@2|Bacteria,2GJ98@201174|Actinobacteria,4CMUH@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
REGS3_k127_957459_8	1313172.YM304_08950	1.171e-52	195.0	COG0454@1|root,COG0456@2|Bacteria,2HGCA@201174|Actinobacteria,4CNAC@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Acetyltransferase (GNAT) domain	-	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
REGS3_k127_957459_7	1313172.YM304_08940	4.178e-63	221.0	COG1214@1|root,COG1214@2|Bacteria	2|Bacteria	O	tRNA threonylcarbamoyladenosine modification	yeaZ	GO:0002949,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070011,GO:0070525,GO:0071704,GO:0090304,GO:0140096,GO:1901360,GO:1901564	2.3.1.234	ko:K01409,ko:K14742	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
REGS3_k127_96472_0	1313172.YM304_15900	5.523e-199	626.0	COG0532@1|root,COG0532@2|Bacteria,2GKPH@201174|Actinobacteria,4CMS2@84992|Acidimicrobiia	84992|Acidimicrobiia	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
REGS3_k127_96472_3	1313172.YM304_15970	1.175e-78	267.0	COG3917@1|root,COG3917@2|Bacteria,2I2EX@201174|Actinobacteria,4CP5E@84992|Acidimicrobiia	84992|Acidimicrobiia	Q	DSBA oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	-
REGS3_k127_96472_4	1313172.YM304_15980	1.616e-36	142.0	COG0858@1|root,COG0858@2|Bacteria,2HGGX@201174|Actinobacteria,4CNEB@84992|Acidimicrobiia	84992|Acidimicrobiia	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
REGS3_k127_96472_2	1313172.YM304_15990	5.235e-105	352.0	COG0130@1|root,COG0130@2|Bacteria,2GJZK@201174|Actinobacteria,4CN62@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	-	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB_C_2,TruB_N
REGS3_k127_96472_1	1313172.YM304_16060	1.028e-141	456.0	COG0196@1|root,COG0196@2|Bacteria,2GKQF@201174|Actinobacteria,4CN39@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Riboflavin kinase	ribF	-	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
## 3277 queries scanned
## Total time (seconds): 376.44095849990845
## Rate: 8.71 q/s