## Mon Nov 11 19:03:07 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/4635/S/SHD1_bin.6.fa -m mmseqs --itype genome -o SHD1_bin.6 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/bins_4635/SHD1_bin.6 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
SHD1_k127_1005253_3	1379270.AUXF01000002_gene1585	6.789e-18	87.0	COG0515@1|root,COG0515@2|Bacteria,1ZUMJ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase
SHD1_k127_1005253_2	1232410.KI421413_gene573	1.771e-45	170.0	COG4276@1|root,COG4276@2|Bacteria,1N6EC@1224|Proteobacteria,42U3N@68525|delta/epsilon subdivisions,2WQTN@28221|Deltaproteobacteria,43VBV@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Pfam Polyketide cyclase dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc
SHD1_k127_1005253_1	666685.R2APBS1_1788	6.133e-91	313.0	COG4313@1|root,COG4313@2|Bacteria,1N5CH@1224|Proteobacteria,1SFFE@1236|Gammaproteobacteria,1X7C2@135614|Xanthomonadales	135614|Xanthomonadales	C	Protein involved in meta-pathway of phenol degradation	-	-	-	-	-	-	-	-	-	-	-	-	Phenol_MetA_deg
SHD1_k127_1005253_0	497964.CfE428DRAFT_4783	4.691e-109	364.0	COG3214@1|root,COG3214@2|Bacteria,46UTW@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_42
SHD1_k127_1005253_4	861299.J421_2040	1.712e-07	53.0	COG0639@1|root,COG0639@2|Bacteria,1ZUFY@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos_2
SHD1_k127_1008506_1	861299.J421_3936	8.071e-105	346.0	COG1409@1|root,COG1409@2|Bacteria,1ZTQ6@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
SHD1_k127_1008506_2	861299.J421_3935	6.629e-68	243.0	2C421@1|root,33VAH@2|Bacteria,1ZTQV@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	SprT-like family	-	-	-	-	-	-	-	-	-	-	-	-	SprT-like
SHD1_k127_1008506_0	379066.GAU_2471	1.301e-209	655.0	COG1960@1|root,COG1960@2|Bacteria,1ZSVE@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.6	ko:K00252	ko00071,ko00310,ko00362,ko00380,ko01100,ko01120,ko01130,map00071,map00310,map00362,map00380,map01100,map01120,map01130	M00032	R02487,R02488,R10074	RC00052,RC00156	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
SHD1_k127_1008506_3	1379270.AUXF01000003_gene3456	2.516e-47	173.0	COG2086@1|root,COG2086@2|Bacteria,1ZT51@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Electron transfer flavoprotein domain	-	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
SHD1_k127_1008890_1	365046.Rta_33970	8.361e-74	252.0	COG1670@1|root,COG1670@2|Bacteria,1MXEE@1224|Proteobacteria,2VKTD@28216|Betaproteobacteria,4ABHT@80864|Comamonadaceae	28216|Betaproteobacteria	J	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
SHD1_k127_1008890_0	1131553.JIBI01000026_gene74	6.731e-74	262.0	COG0753@1|root,COG0753@2|Bacteria,1N4WM@1224|Proteobacteria,2W27I@28216|Betaproteobacteria,373BQ@32003|Nitrosomonadales	28216|Betaproteobacteria	P	Catalase	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_1014779_4	861299.J421_2731	2.227e-98	336.0	COG1195@1|root,COG1195@2|Bacteria,1ZSRU@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP	recF	-	-	ko:K03629	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	SMC_N
SHD1_k127_1014779_3	861299.J421_2732	1.385e-100	334.0	COG1024@1|root,COG1024@2|Bacteria,1ZT76@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	-	ECH_1
SHD1_k127_1014779_2	861299.J421_2733	4.434e-114	395.0	COG3569@1|root,COG3569@2|Bacteria	2|Bacteria	L	DNA topoisomerase type I activity	MA20_25110	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_I
SHD1_k127_1014779_1	1158762.KB898043_gene1117	1.034e-143	471.0	COG0554@1|root,COG0554@2|Bacteria,1MUP7@1224|Proteobacteria,1RMAF@1236|Gammaproteobacteria,1WVYB@135613|Chromatiales	135613|Chromatiales	C	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK	GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
SHD1_k127_1014779_5	861299.J421_2739	1.335e-63	228.0	COG1573@1|root,COG1573@2|Bacteria	2|Bacteria	L	deaminated base DNA N-glycosylase activity	ung	-	3.2.2.27	ko:K03648,ko:K21929	ko03410,ko05340,map03410,map05340	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DUF4130,UDG
SHD1_k127_1014779_6	861299.J421_2741	5.989e-62	216.0	COG2332@1|root,COG2332@2|Bacteria,1ZTNV@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH	-	-	-	ko:K02197	-	-	-	-	ko00000	-	-	-	CcmE
SHD1_k127_1014779_0	379066.GAU_0820	1.06e-310	968.0	COG1138@1|root,COG1138@2|Bacteria,1ZTBY@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	Cytochrome c-type biogenesis protein CcmF C-terminal	-	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
SHD1_k127_1014779_7	861299.J421_2743	6.712e-46	177.0	COG3088@1|root,COG3088@2|Bacteria,1ZTS7@142182|Gemmatimonadetes	142182|Gemmatimonadetes	P	subunit of a heme lyase	-	-	-	ko:K02200	-	-	-	-	ko00000	-	-	-	CcmH
SHD1_k127_1025427_2	314278.NB231_02848	6.199e-22	99.0	COG2102@1|root,COG2102@2|Bacteria,1MUU2@1224|Proteobacteria,1S3D2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	ATPases of PP-loop superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Diphthami_syn_2
SHD1_k127_1025427_1	886293.Sinac_6279	1.638e-38	149.0	COG3682@1|root,COG3682@2|Bacteria,2J0QT@203682|Planctomycetes	203682|Planctomycetes	K	Penicillinase repressor	-	-	-	-	-	-	-	-	-	-	-	-	Penicillinase_R
SHD1_k127_1025427_0	861299.J421_1974	2.51e-40	162.0	COG3595@1|root,COG4219@1|root,COG3595@2|Bacteria,COG4219@2|Bacteria	2|Bacteria	-	-	-	-	3.4.16.4	ko:K01286	-	-	-	-	ko00000,ko01000	-	-	-	DUF4097
SHD1_k127_1027697_2	861299.J421_3829	9.218e-138	451.0	COG2733@1|root,COG2733@2|Bacteria,1ZTAK@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Protein of unknown function (DUF445)	-	-	-	-	-	-	-	-	-	-	-	-	DUF445
SHD1_k127_1027697_0	861299.J421_3828	0.0	1258.0	COG0466@1|root,COG0466@2|Bacteria,1ZTCP@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
SHD1_k127_1027697_1	861299.J421_3827	1.787e-214	673.0	COG0541@1|root,COG0541@2|Bacteria,1ZSPG@142182|Gemmatimonadetes	142182|Gemmatimonadetes	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
SHD1_k127_1027697_6	1379270.AUXF01000003_gene3591	5.513e-34	134.0	COG0228@1|root,COG0228@2|Bacteria,1ZTWQ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Ribosomal protein S16	rpsP	-	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
SHD1_k127_1027697_5	861299.J421_3825	3.401e-41	158.0	COG0806@1|root,COG0806@2|Bacteria,1ZU43@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes	rimM	-	-	ko:K02860	-	-	-	-	ko00000,ko03009	-	-	-	PRC,RimM
SHD1_k127_1027697_3	1379270.AUXF01000003_gene3593	1.421e-100	332.0	COG0336@1|root,COG0336@2|Bacteria,1ZT8K@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Belongs to the RNA methyltransferase TrmD family	trmD	-	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	tRNA_m1G_MT
SHD1_k127_1027697_4	498848.TaqDRAFT_4393	3.675e-60	218.0	COG1404@1|root,COG1404@2|Bacteria,1WIDU@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	O	peptidase S8 and S53, subtilisin, kexin, sedolisin	-	-	3.4.21.111	ko:K20754	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Inhibitor_I9,Peptidase_S8
SHD1_k127_1029582_4	861299.J421_1517	3.253e-29	121.0	COG0457@1|root,COG0457@2|Bacteria	861299.J421_1517|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_1029582_1	861299.J421_1097	2.019e-40	157.0	COG2318@1|root,COG2318@2|Bacteria,1ZV4X@142182|Gemmatimonadetes	2|Bacteria	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB,DinB_2
SHD1_k127_1029582_5	760192.Halhy_4503	1.825e-28	120.0	COG2318@1|root,COG2318@2|Bacteria,4NQEI@976|Bacteroidetes	976|Bacteroidetes	S	Protein of unknown function (DUF1572)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1572
SHD1_k127_1029582_3	1112212.JH584235_gene791	2.419e-32	133.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TY3R@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	His Kinase A (phospho-acceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
SHD1_k127_1029582_2	1230460.C495_09230	1.66e-39	155.0	COG4635@1|root,arCOG00524@2157|Archaea,2XXEG@28890|Euryarchaeota,23V7A@183963|Halobacteria	183963|Halobacteria	C	COG4635 Flavodoxin	-	-	1.3.5.3	ko:K00230	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R09489	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavodoxin_5
SHD1_k127_1029582_0	661478.OP10G_3238	4.519e-56	209.0	COG3832@1|root,COG3832@2|Bacteria	2|Bacteria	J	glyoxalase III activity	-	-	3.4.11.5	ko:K01259	ko00330,map00330	-	R00135	-	ko00000,ko00001,ko01000,ko01002	-	-	-	-
SHD1_k127_1029582_6	1345697.M493_04320	8.728e-26	117.0	COG1210@1|root,COG1210@2|Bacteria,1TQ24@1239|Firmicutes,4HATY@91061|Bacilli,1WERK@129337|Geobacillus	91061|Bacilli	M	Nucleotidyl transferase	-	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
SHD1_k127_1036041_4	861299.J421_3920	1.321e-26	111.0	2F9BP@1|root,341NP@2|Bacteria,1ZTX1@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_1036041_3	861299.J421_3919	5.155e-43	166.0	COG3339@1|root,COG3339@2|Bacteria,1ZTZ7@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Protein of unknown function (DUF1232)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1232
SHD1_k127_1036041_1	1379270.AUXF01000001_gene2176	5.425e-204	648.0	COG0765@1|root,COG0834@1|root,COG0765@2|Bacteria,COG0834@2|Bacteria,1ZURW@142182|Gemmatimonadetes	142182|Gemmatimonadetes	P	Bacterial periplasmic substrate-binding proteins	-	-	-	ko:K02029,ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	BPD_transp_1,SBP_bac_3
SHD1_k127_1036041_2	1379270.AUXF01000001_gene2175	2.564e-74	260.0	COG1126@1|root,COG1126@2|Bacteria,1ZVAS@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	3.6.3.21	ko:K02028	-	M00236	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.3	-	-	ABC_tran
SHD1_k127_1036041_0	379066.GAU_2451	2.206e-259	810.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1ZTG9@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
SHD1_k127_1036041_5	292564.Cyagr_2956	6.646e-06	58.0	COG3146@1|root,COG3146@2|Bacteria,1G0U8@1117|Cyanobacteria,22S1K@167375|Cyanobium	1117|Cyanobacteria	S	Peptidogalycan biosysnthesis/recognition	-	-	-	ko:K09919	-	-	-	-	ko00000	-	-	-	FemAB_like
SHD1_k127_1051402_0	639030.JHVA01000001_gene1853	1.772e-224	699.0	COG4447@1|root,COG4447@2|Bacteria,3Y3TM@57723|Acidobacteria,2JHSZ@204432|Acidobacteriia	204432|Acidobacteriia	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR
SHD1_k127_1051402_4	497964.CfE428DRAFT_3867	3.205e-35	142.0	COG1977@1|root,COG1977@2|Bacteria	2|Bacteria	H	Mo-molybdopterin cofactor metabolic process	-	-	2.7.7.80,2.8.1.11	ko:K03636,ko:K21147	ko04122,map04122	-	R07459,R07461	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiS
SHD1_k127_1051402_2	861299.J421_3386	1.393e-76	261.0	COG1762@1|root,COG1762@2|Bacteria,1ZTIY@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2	-	-	-	ko:K02806	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	PTS_EIIA_2
SHD1_k127_1051402_1	861299.J421_3385	6.199e-158	508.0	COG0042@1|root,COG0042@2|Bacteria,1ZSQC@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	-	-	-	-	-	-	-	-	-	-	-	-	Dus
SHD1_k127_1051402_3	880072.Desac_1009	1.804e-73	255.0	COG1691@1|root,COG1691@2|Bacteria,1REQ7@1224|Proteobacteria,42MJG@68525|delta/epsilon subdivisions,2WN0G@28221|Deltaproteobacteria,2MQYR@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	AIR carboxylase	-	-	-	ko:K06898	-	-	-	-	ko00000	-	-	-	AIRC
SHD1_k127_1059488_0	290397.Adeh_0450	4.208e-121	398.0	COG0380@1|root,COG1877@1|root,COG0380@2|Bacteria,COG1877@2|Bacteria,1MUIY@1224|Proteobacteria,42NBU@68525|delta/epsilon subdivisions,2WJX9@28221|Deltaproteobacteria,2YU3V@29|Myxococcales	28221|Deltaproteobacteria	G	glycosyl transferase family	otsAB	-	2.4.1.15,2.4.1.347,3.1.3.12	ko:K00697,ko:K16055	ko00500,ko01100,map00500,map01100	-	R02737,R02778	RC00005,RC00017,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT20	-	Glyco_transf_20,S6PP,Trehalose_PPase
SHD1_k127_1059488_2	1165096.ARWF01000001_gene696	9.345e-83	286.0	COG0753@1|root,COG0753@2|Bacteria,1MUXZ@1224|Proteobacteria,2VR06@28216|Betaproteobacteria,2KMIJ@206350|Nitrosomonadales	206350|Nitrosomonadales	P	Has an organic peroxide-dependent peroxidase activity	-	-	1.11.1.6	ko:K03781	ko00380,ko00630,ko01110,ko01130,ko01200,ko04011,ko04016,ko04068,ko04146,ko04211,ko04212,ko04213,ko05014,map00380,map00630,map01110,map01130,map01200,map04011,map04016,map04068,map04146,map04211,map04212,map04213,map05014	M00532	R00009,R00602,R02670	RC00034,RC00767,RC02141,RC02755	ko00000,ko00001,ko00002,ko01000	-	-	-	Catalase
SHD1_k127_1059488_1	479434.Sthe_0342	1.863e-94	318.0	COG1018@1|root,COG1018@2|Bacteria,2G7Q7@200795|Chloroflexi	200795|Chloroflexi	C	PFAM oxidoreductase FAD NAD(P)-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_6,NAD_binding_1
SHD1_k127_1059488_3	685778.AORL01000010_gene3034	7.088e-17	79.0	COG2041@1|root,COG2041@2|Bacteria,1MWZK@1224|Proteobacteria,2TTCH@28211|Alphaproteobacteria,2K27H@204457|Sphingomonadales	204457|Sphingomonadales	S	Oxidoreductase molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_molyb
SHD1_k127_1064929_2	1122137.AQXF01000003_gene2417	1.571e-64	234.0	COG2234@1|root,COG2234@2|Bacteria,1NVWC@1224|Proteobacteria	1224|Proteobacteria	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
SHD1_k127_1064929_0	1227739.Hsw_2972	2.693e-148	486.0	COG1288@1|root,COG1288@2|Bacteria,4NEUI@976|Bacteroidetes,47MN0@768503|Cytophagia	976|Bacteroidetes	S	C4-dicarboxylate anaerobic carrier	-	-	-	-	-	-	-	-	-	-	-	-	DcuC
SHD1_k127_1064929_1	1349767.GJA_3764	3.525e-93	316.0	COG1597@1|root,COG1597@2|Bacteria,1MY37@1224|Proteobacteria,2VZ36@28216|Betaproteobacteria,472UX@75682|Oxalobacteraceae	28216|Betaproteobacteria	G	Diacylglycerol kinase	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
SHD1_k127_106773_0	861299.J421_3576	2.001e-181	573.0	COG0202@1|root,COG0202@2|Bacteria,1ZTEV@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	-	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
SHD1_k127_106773_2	861299.J421_3575	1.376e-55	196.0	COG0203@1|root,COG0203@2|Bacteria,1ZTPM@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Ribosomal protein L17	rplQ	-	-	ko:K02879	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L17
SHD1_k127_106773_3	861299.J421_3574	9.203e-28	113.0	COG0227@1|root,COG0227@2|Bacteria,1ZU22@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Ribosomal L28 family	rpmB	-	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
SHD1_k127_106773_1	379066.GAU_1970	7.311e-69	236.0	COG1089@1|root,COG1089@2|Bacteria,1ZSR1@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose	gmd	-	4.2.1.47	ko:K01711	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R00888	RC00402	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
SHD1_k127_1075093_7	1242864.D187_004161	4.701e-42	168.0	COG0300@1|root,COG0300@2|Bacteria,1RG9T@1224|Proteobacteria,43BR5@68525|delta/epsilon subdivisions,2X725@28221|Deltaproteobacteria,2Z30J@29|Myxococcales	28221|Deltaproteobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	ko:K07124	-	-	-	-	ko00000	-	-	-	adh_short
SHD1_k127_1075093_1	339670.Bamb_4035	1.172e-148	478.0	COG0667@1|root,COG0667@2|Bacteria,1MVEH@1224|Proteobacteria,2VH1Q@28216|Betaproteobacteria,1K10Z@119060|Burkholderiaceae	28216|Betaproteobacteria	C	aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
SHD1_k127_1075093_8	861299.J421_1705	1.415e-34	146.0	COG0671@1|root,COG0671@2|Bacteria	2|Bacteria	I	phosphatidate phosphatase activity	dgkA	-	2.7.1.107,3.1.3.27,3.1.3.4,3.1.3.81,3.6.1.27	ko:K00901,ko:K01096,ko:K19302	ko00550,ko00561,ko00564,ko01100,ko01110,ko04070,ko04072,ko05231,map00550,map00561,map00564,map01100,map01110,map04070,map04072,map05231	-	R02029,R02240,R05627	RC00002,RC00017	ko00000,ko00001,ko01000,ko01011	-	-	iAF987.Gmet_2369	DAGK_prokar,PAP2
SHD1_k127_1075093_0	861299.J421_1964	0.0	1242.0	COG0841@1|root,COG0841@2|Bacteria	2|Bacteria	V	transmembrane transporter activity	swrC	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
SHD1_k127_1075093_6	861299.J421_1963	1.794e-43	181.0	COG0845@1|root,COG0845@2|Bacteria	2|Bacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_3
SHD1_k127_1075093_4	861299.J421_1961	4.545e-84	295.0	COG1538@1|root,COG1538@2|Bacteria	2|Bacteria	MU	efflux transmembrane transporter activity	-	-	-	ko:K15725	-	-	-	-	ko00000,ko02000	1.B.17.2.2	-	-	OEP
SHD1_k127_1075093_3	861299.J421_1960	2.424e-95	328.0	COG5002@1|root,COG5002@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
SHD1_k127_1075093_5	379066.GAU_3842	1.084e-68	244.0	COG0745@1|root,COG0745@2|Bacteria,1ZTNE@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Transcriptional regulatory protein, C terminal	-	-	-	ko:K07665	ko02020,map02020	M00452,M00745	-	-	ko00000,ko00001,ko00002,ko01504,ko02022	-	-	-	Response_reg,Trans_reg_C
SHD1_k127_1075093_2	234267.Acid_5600	2.237e-103	347.0	COG3391@1|root,COG3391@2|Bacteria,3Y48Y@57723|Acidobacteria	57723|Acidobacteria	S	TIGRFAM 40-residue YVTN family beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_1086216_5	861299.J421_2524	5.266e-19	93.0	COG0277@1|root,COG0277@2|Bacteria,1ZTRC@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	FAD binding domain	-	-	-	ko:K11472	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	FAD_binding_4
SHD1_k127_1086216_0	861299.J421_2523	4.811e-174	563.0	COG0247@1|root,COG0247@2|Bacteria,1ZSTK@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	4Fe-4S binding domain	-	-	-	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	CCG
SHD1_k127_1086216_6	1183438.GKIL_3560	1.32e-11	73.0	COG0637@1|root,COG0637@2|Bacteria,1G0E4@1117|Cyanobacteria	1117|Cyanobacteria	S	TIGRFAM haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED	-	-	3.1.3.18,5.4.2.6	ko:K01091,ko:K01838	ko00500,ko00630,ko01100,ko01110,ko01130,map00500,map00630,map01100,map01110,map01130	-	R01334,R02728,R11310	RC00017,RC00408	ko00000,ko00001,ko01000	-	-	-	HAD_2
SHD1_k127_1086216_2	861299.J421_2520	1.027e-97	338.0	COG0354@1|root,COG0354@2|Bacteria,1ZTMX@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Glycine cleavage T-protein C-terminal barrel domain	-	-	-	ko:K06980	-	-	-	-	ko00000,ko03016	-	-	-	GCV_T,GCV_T_C
SHD1_k127_1086216_3	886293.Sinac_6848	7.271e-39	162.0	COG0451@1|root,COG0451@2|Bacteria,2J2KW@203682|Planctomycetes	203682|Planctomycetes	GM	PFAM NAD dependent epimerase dehydratase family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
SHD1_k127_1086216_4	251221.35213780	5.267e-34	138.0	COG4293@1|root,COG4293@2|Bacteria,1G555@1117|Cyanobacteria	1117|Cyanobacteria	S	COGs COG4293 conserved	-	-	-	-	-	-	-	-	-	-	-	-	DUF1802
SHD1_k127_1086216_7	946362.XP_004993145.1	2.031e-07	64.0	COG0457@1|root,KOG1124@2759|Eukaryota	2759|Eukaryota	O	cellular component assembly	-	-	-	-	-	-	-	-	-	-	-	-	DUF1736,TPR_16,TPR_8
SHD1_k127_1086216_1	215803.DB30_4795	2.599e-166	535.0	COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,42MYN@68525|delta/epsilon subdivisions,2WIWN@28221|Deltaproteobacteria,2Z2YC@29|Myxococcales	28221|Deltaproteobacteria	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
SHD1_k127_1088527_1	861299.J421_3533	3.465e-132	424.0	COG0439@1|root,COG0439@2|Bacteria,1ZT0Q@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Biotin carboxylase C-terminal domain	-	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
SHD1_k127_1088527_2	861299.J421_3533	5.095e-112	364.0	COG0439@1|root,COG0439@2|Bacteria,1ZT0Q@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Biotin carboxylase C-terminal domain	-	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
SHD1_k127_1088527_3	861299.J421_3532	3.335e-89	311.0	COG2045@1|root,COG2045@2|Bacteria,1ZTM8@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	2-phosphosulpholactate phosphatase	comB	-	3.1.3.71	ko:K05979	ko00680,ko01120,map00680,map01120	M00358	R05789	RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	2-ph_phosp
SHD1_k127_1088527_0	861299.J421_3531	8.063e-255	813.0	COG1674@1|root,COG1674@2|Bacteria,1ZSPI@142182|Gemmatimonadetes	142182|Gemmatimonadetes	D	Ftsk_gamma	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
SHD1_k127_1089117_1	575540.Isop_3340	3.031e-34	142.0	COG0451@1|root,COG0451@2|Bacteria,2J2KW@203682|Planctomycetes	203682|Planctomycetes	GM	PFAM NAD dependent epimerase dehydratase family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
SHD1_k127_1089117_2	1128421.JAGA01000002_gene57	1.573e-11	76.0	COG0392@1|root,COG0392@2|Bacteria,2NPGZ@2323|unclassified Bacteria	2|Bacteria	S	Lysylphosphatidylglycerol synthase TM region	mprF	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
SHD1_k127_1089117_0	1379270.AUXF01000004_gene2877	2.588e-39	166.0	2A0JD@1|root,30NPJ@2|Bacteria,1ZUVV@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
SHD1_k127_1097548_0	379066.GAU_0737	1.003e-257	800.0	COG0587@1|root,COG0587@2|Bacteria,1ZT8N@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	Helix-hairpin-helix motif	-	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP
SHD1_k127_1097548_1	1379270.AUXF01000004_gene3141	3.094e-166	530.0	COG0587@1|root,COG0587@2|Bacteria,1ZT8N@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	Helix-hairpin-helix motif	-	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP
SHD1_k127_1097548_2	861299.J421_2655	1.131e-157	501.0	COG0825@1|root,COG0825@2|Bacteria,1ZSW6@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA	accA	-	2.1.3.15,6.4.1.2	ko:K01962	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	ACCA
SHD1_k127_1097548_3	1379270.AUXF01000004_gene3143	3.345e-85	296.0	COG1774@1|root,COG1774@2|Bacteria,1ZTE8@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	PSP1 C-terminal conserved region	-	-	-	-	-	-	-	-	-	-	-	-	PSP1
SHD1_k127_1108179_1	861299.J421_1312	5.72e-52	186.0	COG2318@1|root,COG2318@2|Bacteria,1ZV4R@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
SHD1_k127_1108179_0	861299.J421_0240	2.929e-160	522.0	COG2091@1|root,COG2091@2|Bacteria,1ZUPU@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Carbohydrate family 9 binding domain-like	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
SHD1_k127_1110425_2	861299.J421_2755	4.928e-66	234.0	COG0628@1|root,COG0628@2|Bacteria	2|Bacteria	D	permease	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
SHD1_k127_1110425_0	1379270.AUXF01000004_gene3061	1.393e-99	331.0	COG1842@1|root,COG1842@2|Bacteria,1ZT82@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KT	PspA/IM30 family	-	-	-	ko:K03969	-	-	-	-	ko00000	-	-	-	PspA_IM30
SHD1_k127_1110425_3	861299.J421_2753	1.502e-55	207.0	2E9HN@1|root,333QR@2|Bacteria,1ZTU1@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_1110425_1	861299.J421_2752	1.471e-82	276.0	COG1760@1|root,COG1760@2|Bacteria,1ZT3U@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Serine dehydratase alpha chain	-	-	4.3.1.17	ko:K01752	ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230	-	R00220,R00590	RC00331,RC02600	ko00000,ko00001,ko01000	-	-	-	SDH_alpha
SHD1_k127_1113679_4	1333998.M2A_1970	1.761e-35	150.0	COG0578@1|root,COG0578@2|Bacteria,1MUMY@1224|Proteobacteria,2TU11@28211|Alphaproteobacteria,4BPQ9@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	C-terminal domain of alpha-glycerophosphate oxidase	-	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,DAO_C
SHD1_k127_1113679_3	472759.Nhal_3328	8.4e-60	226.0	COG0463@1|root,COG0463@2|Bacteria,1MWE5@1224|Proteobacteria,1RPCE@1236|Gammaproteobacteria,1WXFS@135613|Chromatiales	1236|Gammaproteobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
SHD1_k127_1113679_1	766499.C357_22955	9.35e-83	286.0	COG0463@1|root,COG0463@2|Bacteria,1MW2G@1224|Proteobacteria,2TTR9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
SHD1_k127_1113679_2	766499.C357_23020	7.931e-74	263.0	COG0438@1|root,COG0438@2|Bacteria,1RBYC@1224|Proteobacteria,2U6QI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
SHD1_k127_1113679_6	68170.KL590496_gene9341	2.604e-10	71.0	COG0500@1|root,COG2226@2|Bacteria,2GJSF@201174|Actinobacteria,4E0Y7@85010|Pseudonocardiales	201174|Actinobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
SHD1_k127_1113679_8	1150469.RSPPHO_02782	0.0005538	45.0	COG3420@1|root,COG3420@2|Bacteria	2|Bacteria	P	alginic acid biosynthetic process	-	-	-	ko:K10297	-	-	-	-	ko00000,ko04121	-	-	-	Beta_helix,SLH,TIR_2
SHD1_k127_1113679_5	1384054.N790_09210	9.428e-19	94.0	COG1595@1|root,COG1595@2|Bacteria,1RI1M@1224|Proteobacteria,1S780@1236|Gammaproteobacteria,1X678@135614|Xanthomonadales	135614|Xanthomonadales	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
SHD1_k127_1113679_0	1379270.AUXF01000002_gene1390	2.447e-157	533.0	COG1629@1|root,COG4771@2|Bacteria,1ZT7X@142182|Gemmatimonadetes	142182|Gemmatimonadetes	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
SHD1_k127_1114502_0	379066.GAU_3141	0.0	1112.0	COG0726@1|root,COG1215@1|root,COG3858@1|root,COG3946@1|root,COG0726@2|Bacteria,COG1215@2|Bacteria,COG3858@2|Bacteria,COG3946@2|Bacteria,1ZUIV@142182|Gemmatimonadetes	142182|Gemmatimonadetes	GM	Glycosyl hydrolases family 18	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_18,Glyco_tranf_2_3,Polysacc_deac_1
SHD1_k127_1114502_1	1379270.AUXF01000004_gene2961	2.011e-66	234.0	COG0405@1|root,COG0405@2|Bacteria,1ZT0E@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
SHD1_k127_1117240_7	379066.GAU_3112	3.697e-67	242.0	COG0789@1|root,COG0789@2|Bacteria	2|Bacteria	K	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding	nolA	-	-	ko:K19591	-	M00769	-	-	ko00000,ko00002,ko01504,ko03000	-	-	-	Glyoxalase,MerR_1,TipAS
SHD1_k127_1117240_1	861299.J421_2448	6.969e-134	442.0	COG0265@1|root,COG2234@1|root,COG0265@2|Bacteria,COG2234@2|Bacteria,1ZTZW@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
SHD1_k127_1117240_3	1198114.AciX9_3771	3.814e-102	347.0	COG1228@1|root,COG1228@2|Bacteria,3Y47R@57723|Acidobacteria,2JMEC@204432|Acidobacteriia	204432|Acidobacteriia	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
SHD1_k127_1117240_4	861299.J421_2445	1.213e-88	304.0	COG0596@1|root,COG0596@2|Bacteria,1ZTAV@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Serine aminopeptidase, S33	-	-	3.4.11.5	ko:K01259	ko00330,map00330	-	R00135	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Abhydrolase_6
SHD1_k127_1117240_9	379066.GAU_0537	5.736e-35	139.0	2C4KS@1|root,30283@2|Bacteria,1ZUZI@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_1117240_0	861299.J421_2444	6.158e-216	684.0	COG1387@1|root,COG1796@1|root,COG1387@2|Bacteria,COG1796@2|Bacteria,1ZTG4@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	DNA polymerase alpha chain like domain	-	-	-	ko:K02347	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_thumb,HHH_5
SHD1_k127_1117240_5	861299.J421_2443	2.321e-81	278.0	COG0177@1|root,COG0177@2|Bacteria,1ZT7K@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
SHD1_k127_1117240_6	379066.GAU_0534	4.41e-72	247.0	COG0652@1|root,COG0652@2|Bacteria,1ZTQ4@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	-	-	5.2.1.8	ko:K03768	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Pro_isomerase
SHD1_k127_1117240_8	379066.GAU_0532	1.067e-48	182.0	COG1309@1|root,COG1309@2|Bacteria,1ZTT6@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Bacterial transcriptional repressor C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_11,TetR_N
SHD1_k127_1117240_2	861299.J421_2437	7.287e-106	359.0	COG1538@1|root,COG1538@2|Bacteria,1ZSUV@142182|Gemmatimonadetes	142182|Gemmatimonadetes	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
SHD1_k127_1118647_1	1379270.AUXF01000001_gene2636	6.155e-82	298.0	COG0553@1|root,COG0553@2|Bacteria,1ZUB8@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	SNF2 family N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,SNF2_N
SHD1_k127_1118647_0	861299.J421_4374	3.475e-291	927.0	COG0827@1|root,COG1002@1|root,COG0827@2|Bacteria,COG1002@2|Bacteria,1ZT3Q@142182|Gemmatimonadetes	142182|Gemmatimonadetes	LV	DNA restriction-modification system	-	-	-	-	-	-	-	-	-	-	-	-	N6_Mtase
SHD1_k127_1118647_2	693977.Deipr_1738	1.592e-09	66.0	COG0463@1|root,COG0463@2|Bacteria,1WNDV@1297|Deinococcus-Thermus	2|Bacteria	M	PFAM Glycosyl transferase family 2	-	-	2.4.1.83,2.7.8.12	ko:K00721,ko:K09809	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glyco_tranf_2_3,Glycos_transf_2,Polysacc_synt_3
SHD1_k127_1126256_1	1128421.JAGA01000002_gene1962	9.428e-79	267.0	COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,2NQDQ@2323|unclassified Bacteria	2|Bacteria	P	Rhodanese Homology Domain	baeB	-	3.1.2.6,3.4.21.102	ko:K01069,ko:K03797	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000,ko01002	-	-	-	Lactamase_B,Rhodanese
SHD1_k127_1126256_2	42256.RradSPS_2976	5.338e-23	105.0	COG3453@1|root,COG3453@2|Bacteria	2|Bacteria	J	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF442
SHD1_k127_1126256_0	861299.J421_3038	1.089e-139	467.0	COG0308@1|root,COG0823@1|root,COG0308@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	VVA0929	-	3.4.11.2	ko:K01256,ko:K03641	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002,ko02000	2.C.1.2	-	-	PD40,Peptidase_MA_2
SHD1_k127_1140346_0	234267.Acid_4623	1.863e-314	981.0	COG4447@1|root,COG4447@2|Bacteria,3Y2SN@57723|Acidobacteria	57723|Acidobacteria	S	Sortilin, neurotensin receptor 3,	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
SHD1_k127_1143050_0	861299.J421_2007	2.115e-279	885.0	COG4262@1|root,COG4262@2|Bacteria,1ZU7C@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	speE	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synth
SHD1_k127_1144434_4	1379270.AUXF01000004_gene3246	2.932e-30	125.0	COG0305@1|root,COG0305@2|Bacteria,1ZUU3@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	DnaB-like helicase C terminal domain	-	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_C
SHD1_k127_1144434_1	861299.J421_2581	6.529e-97	328.0	COG0217@1|root,COG0217@2|Bacteria,1ZTF4@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
SHD1_k127_1144434_3	861299.J421_2580	2.743e-68	235.0	COG0817@1|root,COG0817@2|Bacteria,1ZTKI@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group	ruvC	-	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
SHD1_k127_1144434_2	861299.J421_2579	1.566e-80	272.0	COG0632@1|root,COG0632@2|Bacteria,1ZTR0@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB	ruvA	-	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
SHD1_k127_1144434_0	861299.J421_2577	2.404e-187	592.0	COG0436@1|root,COG0436@2|Bacteria,1ZT26@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Aminotransferase class I and II	-	-	-	ko:K10907	-	-	-	-	ko00000,ko01000,ko01007	-	-	-	Aminotran_1_2
SHD1_k127_1144434_5	1379270.AUXF01000004_gene3254	3.745e-28	115.0	COG2255@1|root,COG2255@2|Bacteria,1ZT9W@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
SHD1_k127_115489_2	861299.J421_2368	7.739e-57	211.0	2EXE5@1|root,33QQP@2|Bacteria,1ZTI3@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_115489_0	135651.CBN08690	4.194e-133	439.0	COG0183@1|root,KOG1391@2759|Eukaryota,39QWG@33154|Opisthokonta,3BAQ0@33208|Metazoa,3CS5N@33213|Bilateria,40FIP@6231|Nematoda,1KY8Z@119089|Chromadorea,40YFI@6236|Rhabditida	33208|Metazoa	I	Belongs to the thiolase family	ACAA2	GO:0001666,GO:0003674,GO:0003824,GO:0003988,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006066,GO:0006082,GO:0006084,GO:0006139,GO:0006163,GO:0006629,GO:0006631,GO:0006635,GO:0006637,GO:0006694,GO:0006695,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006839,GO:0006915,GO:0006950,GO:0006996,GO:0007005,GO:0007006,GO:0008150,GO:0008152,GO:0008202,GO:0008203,GO:0008219,GO:0008610,GO:0008637,GO:0009056,GO:0009058,GO:0009062,GO:0009117,GO:0009150,GO:0009259,GO:0009628,GO:0009966,GO:0009968,GO:0009987,GO:0010639,GO:0010646,GO:0010648,GO:0010821,GO:0010823,GO:0010941,GO:0012501,GO:0016042,GO:0016043,GO:0016054,GO:0016125,GO:0016126,GO:0016408,GO:0016740,GO:0016746,GO:0016747,GO:0019395,GO:0019637,GO:0019693,GO:0019752,GO:0023051,GO:0023057,GO:0030258,GO:0031974,GO:0032787,GO:0032879,GO:0033043,GO:0033554,GO:0033865,GO:0033875,GO:0034032,GO:0034440,GO:0034641,GO:0035383,GO:0035795,GO:0036293,GO:0036294,GO:0042221,GO:0042981,GO:0043066,GO:0043067,GO:0043069,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046165,GO:0046395,GO:0046483,GO:0046902,GO:0048519,GO:0048523,GO:0048583,GO:0048585,GO:0050789,GO:0050794,GO:0050896,GO:0051049,GO:0051051,GO:0051128,GO:0051129,GO:0051179,GO:0051186,GO:0051234,GO:0051716,GO:0055086,GO:0055114,GO:0060548,GO:0061024,GO:0065007,GO:0065008,GO:0070013,GO:0070482,GO:0070887,GO:0071453,GO:0071456,GO:0071704,GO:0071840,GO:0072329,GO:0072521,GO:0090559,GO:1901028,GO:1901029,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901575,GO:1901576,GO:1901615,GO:1901617,GO:1902108,GO:1902109,GO:1902652,GO:1902653,GO:1905709,GO:2001233,GO:2001234	2.3.1.16,2.3.1.254	ko:K07508,ko:K17972	ko00062,ko00071,ko00280,ko01100,ko01110,ko01130,ko01212,map00062,map00071,map00280,map01100,map01110,map01130,map01212	M00085,M00087	R00391,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747	RC00004,RC00326,RC00405,RC01702	ko00000,ko00001,ko00002,ko01000,ko03029	-	-	-	Thiolase_C,Thiolase_N
SHD1_k127_115489_1	246197.MXAN_1283	4.725e-114	377.0	COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,42M8G@68525|delta/epsilon subdivisions,2WIYB@28221|Deltaproteobacteria,2YZ2Q@29|Myxococcales	28221|Deltaproteobacteria	C	Dehydrogenase	-	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
SHD1_k127_115489_3	861299.J421_2370	1.005e-36	147.0	2F95J@1|root,341H1@2|Bacteria,1ZTZZ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_115489_4	671143.DAMO_1459	2.449e-35	137.0	COG1215@1|root,COG1215@2|Bacteria,2NPIY@2323|unclassified Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
SHD1_k127_1157184_0	1278073.MYSTI_02455	2.58e-31	142.0	COG0457@1|root,COG0457@2|Bacteria,1NNJ6@1224|Proteobacteria,42PBD@68525|delta/epsilon subdivisions,2WKWJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
SHD1_k127_1171440_3	861299.J421_3192	2.205e-60	210.0	COG0342@1|root,COG0342@2|Bacteria,1ZTBW@142182|Gemmatimonadetes	142182|Gemmatimonadetes	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
SHD1_k127_1171440_1	379066.GAU_1561	7.487e-113	376.0	COG0341@1|root,COG0341@2|Bacteria,1ZSSV@142182|Gemmatimonadetes	142182|Gemmatimonadetes	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	-	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
SHD1_k127_1171440_2	861299.J421_3194	8.25e-93	312.0	COG0084@1|root,COG0084@2|Bacteria,1ZST0@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	TatD related DNase	-	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
SHD1_k127_1171440_0	379066.GAU_3742	2.063e-238	761.0	COG2759@1|root,COG2759@2|Bacteria,1ZUHK@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Formate--tetrahydrofolate ligase	fhs	-	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
SHD1_k127_1178272_3	861299.J421_1183	6.986e-123	402.0	COG0429@1|root,COG0429@2|Bacteria,1ZSTN@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	alpha/beta hydrolase fold	-	-	-	ko:K07019	-	-	-	-	ko00000	-	-	-	Abhydrolase_1
SHD1_k127_1178272_12	861299.J421_1222	3.293e-43	164.0	COG1393@1|root,COG1393@2|Bacteria,1ZTUV@142182|Gemmatimonadetes	142182|Gemmatimonadetes	P	ArsC family	-	-	-	-	-	-	-	-	-	-	-	-	ArsC
SHD1_k127_1178272_0	861299.J421_1236	6.611e-252	794.0	COG0488@1|root,COG0488@2|Bacteria,1ZSV1@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	ABC transporter	-	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_Xtn
SHD1_k127_1178272_2	379066.GAU_0128	5.692e-132	439.0	COG0812@1|root,COG0812@2|Bacteria,1ZSMJ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	Cell wall formation	murB	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
SHD1_k127_1178272_8	861299.J421_1265	5.706e-78	267.0	COG0139@1|root,COG0140@1|root,COG0139@2|Bacteria,COG0140@2|Bacteria,1ZTGG@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Phosphoribosyl-AMP cyclohydrolase	hisI	-	3.5.4.19,3.6.1.31	ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035,R04037	RC00002,RC01055	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-CH,PRA-PH
SHD1_k127_1178272_6	861299.J421_1267	1.259e-101	338.0	COG0483@1|root,COG0483@2|Bacteria,1ZTFW@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	Inositol monophosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Inositol_P
SHD1_k127_1178272_5	861299.J421_1268	2.617e-104	344.0	COG0107@1|root,COG0107@2|Bacteria,1ZT55@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	-	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
SHD1_k127_1178272_10	861299.J421_1269	3.544e-58	204.0	COG0131@1|root,COG0131@2|Bacteria,1ZTHU@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Imidazoleglycerol-phosphate dehydratase	hisB	-	4.2.1.19	ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03457	RC00932	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPD
SHD1_k127_1178272_14	861299.J421_1269	2.753e-10	61.0	COG0131@1|root,COG0131@2|Bacteria,1ZTHU@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Imidazoleglycerol-phosphate dehydratase	hisB	-	4.2.1.19	ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03457	RC00932	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPD
SHD1_k127_1178272_7	861299.J421_1270	7.283e-89	304.0	COG0106@1|root,COG0106@2|Bacteria,1ZSZJ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Histidine biosynthesis protein	hisA	-	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
SHD1_k127_1178272_9	246197.MXAN_4227	1.106e-70	252.0	COG0118@1|root,COG0118@2|Bacteria,1QX9Z@1224|Proteobacteria,43C38@68525|delta/epsilon subdivisions,2X7DV@28221|Deltaproteobacteria,2Z2X6@29|Myxococcales	28221|Deltaproteobacteria	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	-	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
SHD1_k127_1178272_1	379066.GAU_0139	2.001e-226	729.0	COG0079@1|root,COG0141@1|root,COG0079@2|Bacteria,COG0141@2|Bacteria,1ZT8V@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	-	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
SHD1_k127_1178272_4	861299.J421_1274	3.062e-118	387.0	COG0040@1|root,COG0040@2|Bacteria,1ZSZP@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	ATP phosphoribosyltransferase	hisG	-	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG,HisG_C
SHD1_k127_1178272_11	861299.J421_1276	2.149e-47	179.0	COG3794@1|root,COG3794@2|Bacteria,1ZTTE@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Copper binding proteins, plastocyanin/azurin family	-	-	-	ko:K02638	ko00195,map00195	-	-	-	ko00000,ko00001,ko00194	-	-	-	Copper-bind
SHD1_k127_1178272_13	861299.J421_1278	1.646e-23	110.0	COG0489@1|root,COG0489@2|Bacteria	2|Bacteria	D	protein tyrosine kinase activity	-	-	-	ko:K16692	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	AAA_31,CBP_BcsQ
SHD1_k127_1181744_2	1120983.KB894577_gene3579	7.8e-20	99.0	COG1402@1|root,COG1402@2|Bacteria,1MXR9@1224|Proteobacteria,2U6JP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Creatinine amidohydrolase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
SHD1_k127_1181744_0	1120983.KB894577_gene3578	2.122e-163	521.0	COG0673@1|root,COG0673@2|Bacteria,1PGFP@1224|Proteobacteria,2V8DN@28211|Alphaproteobacteria,1JQA3@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
SHD1_k127_1181744_1	1120983.KB894577_gene3577	4.949e-29	130.0	COG1802@1|root,COG1802@2|Bacteria,1RDQP@1224|Proteobacteria,2URM2@28211|Alphaproteobacteria,1JQND@119043|Rhodobiaceae	28211|Alphaproteobacteria	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
SHD1_k127_1185709_0	1380391.JIAS01000017_gene543	1.306e-196	627.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
SHD1_k127_1185709_1	1379270.AUXF01000003_gene3512	2.708e-174	559.0	COG0466@1|root,COG0466@2|Bacteria,1ZT5P@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
SHD1_k127_1202302_2	861299.J421_5846	5.427e-149	481.0	COG0457@1|root,COG3629@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3629@2|Bacteria,COG5616@2|Bacteria	2|Bacteria	S	cAMP biosynthetic process	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	AAA_16,BTAD,TPR_12,Trans_reg_C
SHD1_k127_1202302_5	861299.J421_5847	1.131e-34	139.0	2E3HM@1|root,30MSF@2|Bacteria,1ZV6S@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_1202302_4	861299.J421_5848	9.027e-38	151.0	2API8@1|root,31EM9@2|Bacteria,1ZV7F@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Protein of unknown function (DUF4242)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4242
SHD1_k127_1202302_6	1396141.BATP01000032_gene4291	2.911e-17	92.0	COG0454@1|root,COG0456@2|Bacteria,46XJ9@74201|Verrucomicrobia,2IW25@203494|Verrucomicrobiae	203494|Verrucomicrobiae	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
SHD1_k127_1202302_0	861299.J421_2420	7.173e-202	651.0	COG3379@1|root,COG3379@2|Bacteria	2|Bacteria	S	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
SHD1_k127_1202302_3	861299.J421_2419	9.852e-92	311.0	2C4I0@1|root,32SKD@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
SHD1_k127_1202302_1	861299.J421_2418	1.982e-151	494.0	COG2303@1|root,COG2303@2|Bacteria,1ZUUJ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	GMC oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C
SHD1_k127_1202302_7	1449063.JMLS01000018_gene5906	0.0003521	45.0	COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1TPMS@1239|Firmicutes,4HAQD@91061|Bacilli,26RK0@186822|Paenibacillaceae	91061|Bacilli	NT	chemotaxis protein	cheA	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,P2
SHD1_k127_1209142_4	1379270.AUXF01000004_gene3064	1.438e-41	155.0	COG1760@1|root,COG1760@2|Bacteria,1ZT3U@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Serine dehydratase alpha chain	-	-	4.3.1.17	ko:K01752	ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230	-	R00220,R00590	RC00331,RC02600	ko00000,ko00001,ko01000	-	-	-	SDH_alpha
SHD1_k127_1209142_2	1379270.AUXF01000004_gene3065	1.851e-99	342.0	COG1760@1|root,COG1760@2|Bacteria,1ZTFS@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Serine dehydratase beta chain	-	-	4.3.1.17	ko:K01752	ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230	-	R00220,R00590	RC00331,RC02600	ko00000,ko00001,ko01000	-	-	-	ACT,SDH_beta
SHD1_k127_1209142_0	861299.J421_2748	0.0	1540.0	COG0178@1|root,COG0178@2|Bacteria,1ZTDJ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
SHD1_k127_1209142_5	861299.J421_2745	5.338e-38	145.0	COG1324@1|root,COG1324@2|Bacteria,1ZV6V@142182|Gemmatimonadetes	142182|Gemmatimonadetes	P	CutA1 divalent ion tolerance protein	-	-	-	ko:K03926	-	-	-	-	ko00000	-	-	-	CutA1
SHD1_k127_1209142_1	379066.GAU_0826	1.091e-113	371.0	COG1131@1|root,COG1131@2|Bacteria,1ZUPB@142182|Gemmatimonadetes	142182|Gemmatimonadetes	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SHD1_k127_1209142_3	1379270.AUXF01000004_gene3069	1.258e-65	238.0	28M0D@1|root,2ZAFE@2|Bacteria,1ZUP5@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Putative ATP-binding cassette	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran_2
SHD1_k127_1209861_2	1128421.JAGA01000002_gene11	1.005e-31	128.0	COG4277@1|root,COG4277@2|Bacteria	2|Bacteria	-	-	MA20_15955	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	HHH_3,Radical_SAM
SHD1_k127_1209861_0	1210884.HG799465_gene12236	6.642e-274	863.0	COG1506@1|root,COG1506@2|Bacteria,2IYRT@203682|Planctomycetes	203682|Planctomycetes	E	Dipeptidyl peptidase IV (DPP IV)	-	-	3.4.14.5	ko:K01278	ko04974,map04974	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	DPPIV_N,Peptidase_S9
SHD1_k127_1209861_1	460265.Mnod_3274	1.891e-32	127.0	COG2010@1|root,COG2133@1|root,COG2010@2|Bacteria,COG2133@2|Bacteria,1MVK5@1224|Proteobacteria,2TRN9@28211|Alphaproteobacteria,1JTMF@119045|Methylobacteriaceae	28211|Alphaproteobacteria	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3,GSDH
SHD1_k127_1217857_5	379066.GAU_0558	5.677e-43	162.0	COG0646@1|root,COG0685@1|root,COG0646@2|Bacteria,COG0685@2|Bacteria,1ZT6C@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Methylenetetrahydrofolate reductase	-	-	1.5.1.20,2.1.1.10	ko:K00297,ko:K00547	ko00270,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01523,map00270,map00670,map00720,map01100,map01110,map01120,map01200,map01523	M00377	R00650,R01224,R07168	RC00003,RC00035,RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR,S-methyl_trans
SHD1_k127_1217857_0	485913.Krac_11199	0.0	1363.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,2G5Y6@200795|Chloroflexi	200795|Chloroflexi	H	Methionine synthase B12-binding module cap domain protein	-	-	2.1.1.13,2.1.1.258	ko:K00548,ko:K15023	ko00270,ko00450,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01230,map00270,map00450,map00670,map00720,map01100,map01110,map01120,map01200,map01230	M00017,M00377	R00946,R02289,R09365,R10243	RC00004,RC00035,RC00113,RC01144,RC01241,RC02871,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
SHD1_k127_1217857_4	861299.J421_2472	8.395e-46	173.0	COG0762@1|root,COG0762@2|Bacteria,1ZTUJ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	YGGT family	-	-	-	ko:K02221	-	-	-	-	ko00000,ko02044	-	-	-	YGGT
SHD1_k127_1217857_1	1173024.KI912148_gene4571	8.783e-260	822.0	COG1505@1|root,COG1505@2|Bacteria,1G1B7@1117|Cyanobacteria,1JMTM@1189|Stigonemataceae	1117|Cyanobacteria	E	Prolyl oligopeptidase, N-terminal beta-propeller domain	-	-	3.4.21.26	ko:K01322	ko04614,map04614	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
SHD1_k127_1217857_7	251229.Chro_3487	7.454e-10	71.0	COG4767@1|root,COG4767@2|Bacteria,1G359@1117|Cyanobacteria,3VHTF@52604|Pleurocapsales	1117|Cyanobacteria	V	PFAM VanZ like family	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,VanZ
SHD1_k127_1217857_3	1379270.AUXF01000004_gene3329	5.315e-83	285.0	COG0726@1|root,COG0726@2|Bacteria	2|Bacteria	G	polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	DUF3473,Polysacc_deac_1
SHD1_k127_1217857_2	1379270.AUXF01000004_gene3328	8.145e-84	290.0	COG5653@1|root,COG5653@2|Bacteria	2|Bacteria	M	Protein involved in cellulose biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_6
SHD1_k127_1217857_6	316067.Geob_2974	1.304e-27	127.0	COG0399@1|root,COG0399@2|Bacteria,1PDU2@1224|Proteobacteria,42RZB@68525|delta/epsilon subdivisions,2WNIE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Belongs to the DegT DnrJ EryC1 family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
SHD1_k127_123772_1	1379270.AUXF01000002_gene1768	1.663e-133	429.0	COG0379@1|root,COG0379@2|Bacteria,1ZT10@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	-	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	-	NadA
SHD1_k127_123772_0	861299.J421_2321	3.608e-241	753.0	COG0029@1|root,COG0029@2|Bacteria,1ZT8U@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	-	-	1.4.3.16	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481	RC00006,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
SHD1_k127_1250200_4	861299.J421_0111	4.717e-15	78.0	COG0330@1|root,COG0330@2|Bacteria,1ZUU0@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	prohibitin homologues	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
SHD1_k127_1250200_5	1379270.AUXF01000002_gene1703	6.892e-13	71.0	2BXJX@1|root,2ZFYN@2|Bacteria,1ZV87@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_1250200_1	1123278.KB893559_gene2999	1.4e-51	193.0	COG2116@1|root,COG2116@2|Bacteria,4NFNU@976|Bacteroidetes,47T6Q@768503|Cytophagia	976|Bacteroidetes	P	Formate/nitrite transporter	-	-	-	ko:K21990,ko:K21993	-	-	-	-	ko00000,ko02000	1.A.16.2,1.A.16.4	-	-	Form_Nir_trans
SHD1_k127_1250200_2	1379270.AUXF01000001_gene2750	8.97e-38	151.0	COG0791@1|root,COG0791@2|Bacteria,1ZTV8@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	NlpC/P60 family	-	-	-	-	-	-	-	-	-	-	-	-	NLPC_P60
SHD1_k127_1250200_0	379066.GAU_2801	1.114e-70	244.0	COG0522@1|root,COG0522@2|Bacteria,1ZTGJ@142182|Gemmatimonadetes	2|Bacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rps4	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
SHD1_k127_1250200_3	379066.GAU_3731	3.104e-28	116.0	COG1734@1|root,COG1734@2|Bacteria,1ZV6D@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_1279526_0	555079.Toce_1758	1.847e-188	612.0	COG0210@1|root,COG0210@2|Bacteria,1TPSU@1239|Firmicutes,247RM@186801|Clostridia,42EUR@68295|Thermoanaerobacterales	186801|Clostridia	L	PFAM UvrD REP helicase	pcrA	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
SHD1_k127_1280853_1	1234664.AMRO01000052_gene147	1.067e-18	93.0	COG3764@1|root,COG3764@2|Bacteria,1V1RS@1239|Firmicutes,4HFWK@91061|Bacilli,1WFAJ@129337|Geobacillus	91061|Bacilli	M	Sortase family	-	-	3.4.22.70	ko:K07284	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Sortase
SHD1_k127_1280853_0	861299.J421_4221	3.718e-25	108.0	2FEZ1@1|root,346XM@2|Bacteria,1ZU4U@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_129245_2	1379270.AUXF01000002_gene1539	5.035e-32	127.0	2C7E0@1|root,330TX@2|Bacteria,1ZUQG@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_129245_0	861299.J421_2590	1.657e-168	539.0	COG0162@1|root,COG0162@2|Bacteria,1ZT43@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
SHD1_k127_129245_1	379066.GAU_0644	7.674e-53	192.0	COG5009@1|root,COG5009@2|Bacteria,1ZT3R@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	Transglycosylase	-	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
SHD1_k127_1293343_5	797209.ZOD2009_14486	5.227e-34	137.0	arCOG10456@1|root,arCOG10456@2157|Archaea,2XXKI@28890|Euryarchaeota,23W06@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_1293343_2	485913.Krac_11550	1.964e-89	302.0	COG1814@1|root,COG1814@2|Bacteria,2G7AE@200795|Chloroflexi	200795|Chloroflexi	S	VIT family	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
SHD1_k127_1293343_0	861299.J421_1939	2.467e-189	602.0	COG1236@1|root,COG1236@2|Bacteria,1ZSP5@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Beta-Casp domain	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,RMMBL
SHD1_k127_1293343_1	1379270.AUXF01000003_gene3360	1.63e-159	524.0	COG2217@1|root,COG2217@2|Bacteria,1ZTC7@142182|Gemmatimonadetes	2|Bacteria	P	E1-E2 ATPase	cadA	-	-	-	-	-	-	-	-	-	-	-	E1-E2_ATPase,Hemerythrin,Hydrolase
SHD1_k127_1293343_3	861299.J421_5678	1.98e-70	250.0	COG2197@1|root,COG2197@2|Bacteria,1ZSRV@142182|Gemmatimonadetes	2|Bacteria	K	helix_turn_helix, Lux Regulon	-	-	-	ko:K02282,ko:K07696	ko02020,map02020	M00483	-	-	ko00000,ko00001,ko00002,ko02022,ko02035,ko02044	-	-	-	GerE,Response_reg
SHD1_k127_1293343_4	1174528.JH992892_gene6574	1.169e-60	215.0	COG2823@1|root,COG2823@2|Bacteria,1GCMH@1117|Cyanobacteria	1117|Cyanobacteria	S	BON domain	-	-	-	-	-	-	-	-	-	-	-	-	BON
SHD1_k127_1298729_3	379066.GAU_0464	5.566e-25	116.0	2FK9E@1|root,34BX2@2|Bacteria,1ZTYM@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_1298729_1	671143.DAMO_2551	4.89e-104	346.0	COG1250@1|root,COG1250@2|Bacteria,2NP11@2323|unclassified Bacteria	2|Bacteria	I	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
SHD1_k127_1298729_2	1120973.AQXL01000135_gene1400	1.062e-33	149.0	COG1852@1|root,COG1852@2|Bacteria,1V1B5@1239|Firmicutes,4HUDI@91061|Bacilli,279H3@186823|Alicyclobacillaceae	91061|Bacilli	S	Protein of unknown function DUF116	-	-	-	-	-	-	-	-	-	-	-	-	DUF116
SHD1_k127_1298729_0	861299.J421_2362	2.439e-110	370.0	COG0277@1|root,COG0277@2|Bacteria,1ZTB7@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	FAD linked oxidases, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD-oxidase_C,FAD_binding_4
SHD1_k127_1302379_2	861299.J421_4449	3.345e-27	127.0	COG0515@1|root,COG0515@2|Bacteria,1ZTFJ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Serine/Threonine protein kinases, catalytic domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
SHD1_k127_1302379_0	861299.J421_1102	1.954e-279	870.0	COG0155@1|root,COG0155@2|Bacteria	2|Bacteria	C	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family	-	-	1.7.7.1,1.8.7.1	ko:K00366,ko:K00392	ko00910,ko00920,ko01100,ko01120,map00910,map00920,map01100,map01120	M00176,M00531	R00790,R00859,R03600	RC00065,RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	NIR_SIR,NIR_SIR_ferr
SHD1_k127_1302379_1	1163407.UU7_04612	3.758e-40	165.0	COG0454@1|root,COG0456@2|Bacteria,1RDH4@1224|Proteobacteria,1SCMT@1236|Gammaproteobacteria,1X66P@135614|Xanthomonadales	135614|Xanthomonadales	K	acetyltransferase	-	-	2.3.1.57	ko:K22441	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_10
SHD1_k127_1304480_2	861299.J421_1848	6.336e-19	86.0	COG2207@1|root,COG2207@2|Bacteria,1ZV3U@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	helix_turn_helix, arabinose operon control protein	-	-	-	ko:K07506	-	-	-	-	ko00000,ko03000	-	-	-	AraC_binding,HTH_18
SHD1_k127_1304480_1	1234364.AMSF01000061_gene2077	1.944e-40	157.0	2EUEA@1|root,33MWN@2|Bacteria,1NYM7@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_1304480_0	861299.J421_1695	1.591e-196	625.0	COG0457@1|root,COG0457@2|Bacteria,1ZV58@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	chaperone-mediated protein folding	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_1321405_1	1121377.KB906402_gene3276	1.075e-60	213.0	COG0624@1|root,COG0624@2|Bacteria,1WMF4@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
SHD1_k127_1321405_0	861299.J421_1133	1.533e-153	500.0	COG0531@1|root,COG0531@2|Bacteria	2|Bacteria	E	amino acid	gadC	GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0006873,GO:0006885,GO:0008150,GO:0008509,GO:0008514,GO:0009987,GO:0015075,GO:0015171,GO:0015179,GO:0015291,GO:0015297,GO:0015318,GO:0015711,GO:0015807,GO:0015849,GO:0016020,GO:0016021,GO:0019725,GO:0022804,GO:0022857,GO:0030003,GO:0030004,GO:0030641,GO:0031224,GO:0031226,GO:0034220,GO:0042592,GO:0044425,GO:0044459,GO:0044464,GO:0045852,GO:0046942,GO:0046943,GO:0048878,GO:0050801,GO:0051179,GO:0051234,GO:0051453,GO:0051454,GO:0055067,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071702,GO:0071705,GO:0071944,GO:0098656,GO:0098771,GO:1902475,GO:1903825,GO:1905039	-	ko:K20265	ko02024,map02024	-	-	-	ko00000,ko00001,ko02000	2.A.3.7.1,2.A.3.7.3	-	iEC042_1314.EC042_1624	AA_permease_2
SHD1_k127_1321405_3	861299.J421_1614	8.8e-39	152.0	COG2318@1|root,COG2318@2|Bacteria	2|Bacteria	S	DinB family	yjoA	-	-	-	-	-	-	-	-	-	-	-	DinB,DinB_2
SHD1_k127_1321405_4	1337936.IJ00_01385	7.917e-38	149.0	COG1595@1|root,COG1595@2|Bacteria,1G6A9@1117|Cyanobacteria,1HU8U@1161|Nostocales	1117|Cyanobacteria	K	ECF sigma factor	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
SHD1_k127_1321405_6	994479.GL877878_gene1799	4.216e-13	79.0	COG5343@1|root,COG5343@2|Bacteria,2I8NI@201174|Actinobacteria,4E4IM@85010|Pseudonocardiales	201174|Actinobacteria	S	Anti-sigma-K factor rskA	-	-	-	-	-	-	-	-	-	-	-	-	RskA,zf-HC2
SHD1_k127_1338280_3	861299.J421_3941	1.334e-17	87.0	COG0624@1|root,COG0624@2|Bacteria,1ZTIX@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
SHD1_k127_1338280_0	1192034.CAP_5366	1.829e-127	419.0	COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,42MSP@68525|delta/epsilon subdivisions,2WIUZ@28221|Deltaproteobacteria,2YTZB@29|Myxococcales	28221|Deltaproteobacteria	E	synthase homocitrate synthase family	-	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
SHD1_k127_1338280_2	457570.Nther_2188	1.116e-67	251.0	COG4805@1|root,COG4805@2|Bacteria	2|Bacteria	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
SHD1_k127_1338280_1	926566.Terro_0376	1.075e-103	347.0	COG2706@1|root,COG3391@1|root,COG2706@2|Bacteria,COG3391@2|Bacteria,3Y3TB@57723|Acidobacteria,2JKB3@204432|Acidobacteriia	204432|Acidobacteriia	G	Lactonase, 7-bladed beta-propeller	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
SHD1_k127_1342986_1	671143.DAMO_0102	1.936e-61	239.0	COG4772@1|root,COG4772@2|Bacteria,2NRIP@2323|unclassified Bacteria	2|Bacteria	P	TonB dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
SHD1_k127_1342986_2	1379270.AUXF01000001_gene2379	1.2e-23	107.0	COG1595@1|root,COG1595@2|Bacteria,1ZTNW@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
SHD1_k127_1342986_0	861299.J421_1999	9.693e-183	591.0	COG2312@1|root,COG2312@2|Bacteria	2|Bacteria	S	response to antibiotic	pcm	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	Erythro_esteras,PCMT
SHD1_k127_1355003_0	861299.J421_6011	5.983e-60	213.0	COG2030@1|root,COG2030@2|Bacteria	2|Bacteria	I	dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1569,MaoC_dehydrat_N,MaoC_dehydratas
SHD1_k127_1355003_1	1185876.BN8_03503	1.401e-55	203.0	COG0698@1|root,COG0698@2|Bacteria,4NNSU@976|Bacteroidetes,47PQK@768503|Cytophagia	976|Bacteroidetes	G	Ribose 5-phosphate isomerase	rpiB	-	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	LacAB_rpiB
SHD1_k127_1355003_2	1379270.AUXF01000001_gene2080	9.653e-42	156.0	2E129@1|root,32WI1@2|Bacteria	2|Bacteria	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL,SnoaL_2
SHD1_k127_1356455_5	861299.J421_1428	7.486e-76	267.0	COG1524@1|root,COG1524@2|Bacteria,1ZTCS@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
SHD1_k127_1356455_2	401053.AciPR4_1571	6.433e-99	346.0	COG0526@1|root,COG0785@1|root,COG0526@2|Bacteria,COG0785@2|Bacteria,3Y3U8@57723|Acidobacteria,2JICN@204432|Acidobacteriia	204432|Acidobacteriia	CO	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,DsbD
SHD1_k127_1356455_9	426117.M446_4787	8.126e-41	164.0	COG5662@1|root,COG5662@2|Bacteria,1MV95@1224|Proteobacteria,2TVRG@28211|Alphaproteobacteria,1JU5T@119045|Methylobacteriaceae	28211|Alphaproteobacteria	K	AntiSigma factor	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
SHD1_k127_1356455_10	471852.Tcur_3374	4.984e-27	117.0	COG0454@1|root,COG0454@2|Bacteria,2I2XW@201174|Actinobacteria	201174|Actinobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
SHD1_k127_1356455_8	861299.J421_0446	1.393e-61	224.0	2F3M0@1|root,33WE8@2|Bacteria,1ZTTF@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_1356455_1	861299.J421_0447	1.058e-144	462.0	COG2107@1|root,COG2107@2|Bacteria,1ZTVU@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnD	-	-	ko:K11785	ko00130,ko01110,map00130,map01110	-	R08589	RC02330	ko00000,ko00001,ko01000	-	-	-	VitK2_biosynth
SHD1_k127_1356455_6	290397.Adeh_2020	3.435e-72	263.0	COG1538@1|root,COG1538@2|Bacteria,1MWX5@1224|Proteobacteria,42S0Z@68525|delta/epsilon subdivisions,2WWFY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	MU	CyaE is necessary for transport of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin)	-	-	-	ko:K12340	ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133	M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko02044	1.B.17,2.A.6.2	-	-	OEP
SHD1_k127_1356455_4	1380394.JADL01000001_gene2288	1.452e-81	285.0	COG0845@1|root,COG0845@2|Bacteria,1MW65@1224|Proteobacteria,2TV9W@28211|Alphaproteobacteria,2JRRC@204441|Rhodospirillales	204441|Rhodospirillales	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	-	-	-	ko:K07799	ko02020,map02020	M00648	-	-	ko00000,ko00001,ko00002,ko02000	8.A.1	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
SHD1_k127_1356455_0	379066.GAU_0522	0.0	1154.0	COG0841@1|root,COG0841@2|Bacteria,1ZT98@142182|Gemmatimonadetes	142182|Gemmatimonadetes	V	MMPL family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
SHD1_k127_1356455_7	861299.J421_0458	1.694e-70	242.0	COG0789@1|root,COG0789@2|Bacteria,1ZTHT@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	MerR HTH family regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
SHD1_k127_1356455_3	861299.J421_1403	4.074e-84	290.0	COG1201@1|root,COG1201@2|Bacteria,1ZTN1@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	DEAD/H associated	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
SHD1_k127_1382637_3	1410622.JNKY01000013_gene1601	5.745e-11	66.0	COG0617@1|root,COG0617@2|Bacteria,1TQ2A@1239|Firmicutes,247XC@186801|Clostridia,27IW0@186928|unclassified Lachnospiraceae	186801|Clostridia	J	tRNA nucleotidyltransferase domain 2 putative	cca	-	2.7.7.19,2.7.7.72	ko:K00970,ko:K00974	ko03013,ko03018,map03013,map03018	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd,tRNA_NucTran2_2
SHD1_k127_1382637_2	861299.J421_3510	4.63e-56	200.0	2F9H0@1|root,341TI@2|Bacteria,1ZTXU@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_1382637_1	861299.J421_3509	1.324e-69	246.0	COG0428@1|root,COG0428@2|Bacteria	2|Bacteria	P	transporter	zupT	-	-	ko:K07238,ko:K11021,ko:K16267	-	-	-	-	ko00000,ko02000,ko02042	2.A.5.4.11,2.A.5.5	-	-	Zip
SHD1_k127_1382637_0	861299.J421_3508	1.299e-169	542.0	COG2256@1|root,COG2256@2|Bacteria,1ZTCA@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	MgsA AAA+ ATPase C terminal	-	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA_assoc_2,MgsA_C,RuvB_N
SHD1_k127_1382923_0	211165.AJLN01000100_gene4333	1.631e-119	396.0	COG1091@1|root,COG2723@1|root,COG1091@2|Bacteria,COG2723@2|Bacteria,1G1JP@1117|Cyanobacteria,1JJI6@1189|Stigonemataceae	1117|Cyanobacteria	M	Glycosyl hydrolase family 1	-	-	1.1.1.133	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_1,RmlD_sub_bind
SHD1_k127_1382923_1	1121372.AULK01000012_gene684	3.401e-05	48.0	COG2909@1|root,COG2909@2|Bacteria,2GJXF@201174|Actinobacteria,4FQJ9@85023|Microbacteriaceae	201174|Actinobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
SHD1_k127_1401037_6	1379270.AUXF01000003_gene3818	8.363e-42	159.0	COG0001@1|root,COG0001@2|Bacteria,1ZSWU@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Aminotransferase class-III	-	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
SHD1_k127_1401037_5	861299.J421_3635	4.188e-85	298.0	COG0565@1|root,COG0565@2|Bacteria,1ZT19@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	SpoU rRNA Methylase family	-	-	2.1.1.200	ko:K02533,ko:K15396	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
SHD1_k127_1401037_0	861299.J421_3636	9.362e-253	811.0	2AEF2@1|root,314A1@2|Bacteria,1ZSNZ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Heparinase II/III-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Hepar_II_III
SHD1_k127_1401037_1	861299.J421_3637	1.733e-186	617.0	COG0747@1|root,COG0747@2|Bacteria,1ZTAS@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
SHD1_k127_1401037_2	861299.J421_3638	1.464e-111	369.0	COG0601@1|root,COG0601@2|Bacteria,1ZT46@142182|Gemmatimonadetes	142182|Gemmatimonadetes	U	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
SHD1_k127_1401037_3	861299.J421_3639	5.445e-94	333.0	COG1173@1|root,COG1173@2|Bacteria,1ZTI1@142182|Gemmatimonadetes	142182|Gemmatimonadetes	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
SHD1_k127_1401037_4	861299.J421_3641	8.433e-89	306.0	COG0383@1|root,COG0383@2|Bacteria,1ZT4Q@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	Alpha mannosidase, middle domain	-	-	3.2.1.24	ko:K01191	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04131	-	GH38	-	Alpha-mann_mid,Glyco_hydro_38
SHD1_k127_1420078_2	56110.Oscil6304_2653	2.52e-81	284.0	COG0438@1|root,COG0438@2|Bacteria,1G8JK@1117|Cyanobacteria	1117|Cyanobacteria	M	PFAM Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
SHD1_k127_1420078_4	251229.Chro_2382	3.018e-53	205.0	COG3307@1|root,COG3307@2|Bacteria,1G1VH@1117|Cyanobacteria,3VI3I@52604|Pleurocapsales	1117|Cyanobacteria	M	COGs COG3307 Lipid A core - O-antigen ligase	-	-	-	-	-	-	-	-	-	-	-	-	Wzy_C
SHD1_k127_1420078_3	87626.PTD2_11584	1.324e-62	235.0	COG2244@1|root,COG2244@2|Bacteria,1R9I0@1224|Proteobacteria,1RP3V@1236|Gammaproteobacteria,2Q51P@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	S	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt_3,Polysacc_synt_C
SHD1_k127_1420078_1	756067.MicvaDRAFT_4274	8.685e-103	340.0	COG1922@1|root,COG1922@2|Bacteria,1G0T6@1117|Cyanobacteria,1H8E5@1150|Oscillatoriales	1117|Cyanobacteria	M	Belongs to the glycosyltransferase 26 family	-	-	2.4.1.187	ko:K05946	ko05111,map05111	-	-	-	ko00000,ko00001,ko01000,ko01003	-	GT26	-	Glyco_tran_WecB
SHD1_k127_1420078_0	402777.KB235903_gene1360	1.169e-174	556.0	COG0451@1|root,COG0451@2|Bacteria,1G0IT@1117|Cyanobacteria,1HA8Q@1150|Oscillatoriales	1117|Cyanobacteria	M	PFAM NAD dependent epimerase dehydratase family	-	-	5.1.3.10	ko:K12454	ko00520,map00520	-	R04266	RC00528	ko00000,ko00001,ko01000	-	-	-	Epimerase
SHD1_k127_1420078_5	1300345.LF41_786	3.023e-46	191.0	COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,1MVI9@1224|Proteobacteria,1RNB0@1236|Gammaproteobacteria,1XCG4@135614|Xanthomonadales	135614|Xanthomonadales	D	G-rich domain on putative tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_31,GNVR,Wzz
SHD1_k127_1430578_1	861299.J421_3300	3.988e-58	213.0	2CAZH@1|root,2Z7RU@2|Bacteria,1ZTQ9@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	ko:K00241	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	-
SHD1_k127_1430578_0	861299.J421_3301	2.365e-159	508.0	COG0039@1|root,COG0039@2|Bacteria,1ZSV3@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	-	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
SHD1_k127_1442249_1	765911.Thivi_0740	7.246e-105	354.0	COG3459@1|root,COG3459@2|Bacteria,1MVNX@1224|Proteobacteria,1RMW9@1236|Gammaproteobacteria,1WWWE@135613|Chromatiales	135613|Chromatiales	G	Glycosyltransferase 36 associated	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_36,Glyco_transf_36
SHD1_k127_1442249_0	243233.MCA0553	2.827e-277	889.0	COG3387@1|root,COG3387@2|Bacteria,1MW9J@1224|Proteobacteria,1T2G2@1236|Gammaproteobacteria,1XGVI@135618|Methylococcales	135618|Methylococcales	G	PFAM Glycoside hydrolase 15-related	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_1442249_2	215803.DB30_8573	1.811e-20	91.0	COG0395@1|root,COG0395@2|Bacteria,1MUWS@1224|Proteobacteria,42P8C@68525|delta/epsilon subdivisions,2WJ3R@28221|Deltaproteobacteria,2Z0SJ@29|Myxococcales	28221|Deltaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	ugpE	-	-	ko:K05815	ko02010,map02010	M00198	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.3	-	-	BPD_transp_1
SHD1_k127_1443804_3	861299.J421_4052	4.153e-20	102.0	COG0515@1|root,COG0515@2|Bacteria	861299.J421_4052|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_1443804_2	1123269.NX02_05750	6.258e-28	128.0	COG0491@1|root,COG0491@2|Bacteria,1PKW8@1224|Proteobacteria,2TUW8@28211|Alphaproteobacteria,2K4IM@204457|Sphingomonadales	204457|Sphingomonadales	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
SHD1_k127_1443804_0	861299.J421_1479	2.586e-120	419.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
SHD1_k127_1443804_1	383372.Rcas_2710	7.934e-53	190.0	COG0664@1|root,COG1136@1|root,COG0664@2|Bacteria,COG1136@2|Bacteria,2G6C9@200795|Chloroflexi,37685@32061|Chloroflexia	32061|Chloroflexia	V	ABC transporter related	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,cNMP_binding
SHD1_k127_1447645_1	234267.Acid_1209	7.671e-05	46.0	COG1595@1|root,COG1595@2|Bacteria,3Y589@57723|Acidobacteria	57723|Acidobacteria	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
SHD1_k127_1447645_0	204669.Acid345_1052	7.788e-110	383.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria,3Y2HR@57723|Acidobacteria,2JI02@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Tetratricopeptide repeats	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_11,TPR_16,TPR_2,Trans_reg_C
SHD1_k127_1457597_5	861299.J421_3318	1.34e-72	247.0	COG1573@1|root,COG1573@2|Bacteria,1ZTG5@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	Uracil DNA glycosylase superfamily	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
SHD1_k127_1457597_1	379066.GAU_1686	4.957e-188	598.0	COG0305@1|root,COG0305@2|Bacteria,1ZSMZ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	Participates in initiation and elongation during chromosome replication	-	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
SHD1_k127_1457597_0	861299.J421_3316	1.955e-219	688.0	COG1066@1|root,COG1066@2|Bacteria,1ZSYF@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	ATPase
SHD1_k127_1457597_3	1379270.AUXF01000006_gene207	1.036e-91	316.0	COG1211@1|root,COG1211@2|Bacteria,1ZSTV@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)	ispD	-	2.7.7.60	ko:K00991	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD
SHD1_k127_1457597_2	379066.GAU_1683	4.254e-98	326.0	COG0009@1|root,COG0009@2|Bacteria,1ZT3D@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Telomere recombination	-	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	Sua5_yciO_yrdC
SHD1_k127_1457597_6	861299.J421_3313	7.645e-50	184.0	COG0394@1|root,COG0394@2|Bacteria,1ZTSE@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	Low molecular weight phosphatase family	-	-	3.1.3.48	ko:K01104	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
SHD1_k127_1457597_4	861299.J421_3312	1.149e-84	289.0	COG0169@1|root,COG0169@2|Bacteria,1ZTVG@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	-	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_dh_N
SHD1_k127_1459931_8	379066.GAU_2027	3.647e-64	226.0	COG1802@1|root,COG1802@2|Bacteria,1ZUBC@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
SHD1_k127_1459931_2	1340493.JNIF01000003_gene4527	1.998e-241	787.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,3Y3NT@57723|Acidobacteria	57723|Acidobacteria	EU	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	DPPIV_N,PD40,Peptidase_S9
SHD1_k127_1459931_4	215803.DB30_0411	8.054e-137	457.0	COG1680@1|root,COG1680@2|Bacteria,1MVPR@1224|Proteobacteria,42TQ5@68525|delta/epsilon subdivisions,2WQ0T@28221|Deltaproteobacteria,2YWK1@29|Myxococcales	28221|Deltaproteobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
SHD1_k127_1459931_3	448385.sce8725	5.087e-206	659.0	COG2225@1|root,COG2225@2|Bacteria,1MVEV@1224|Proteobacteria,42P3R@68525|delta/epsilon subdivisions,2X349@28221|Deltaproteobacteria,2YU6W@29|Myxococcales	28221|Deltaproteobacteria	H	Malate synthase	aceB	-	2.3.3.9	ko:K01638	ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200	M00012	R00472	RC00004,RC00308,RC02747	ko00000,ko00001,ko00002,ko01000	-	-	-	Hemerythrin,ICL,Malate_synthase
SHD1_k127_1459931_6	861299.J421_1346	2.436e-105	349.0	COG1266@1|root,COG1266@2|Bacteria	2|Bacteria	V	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
SHD1_k127_1459931_5	861299.J421_1019	2.631e-111	365.0	COG1402@1|root,COG1402@2|Bacteria,1ZTKC@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Creatinine amidohydrolase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
SHD1_k127_1459931_1	861299.J421_6087	5.568e-275	859.0	COG2936@1|root,COG2936@2|Bacteria,1ZTD6@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
SHD1_k127_1459931_9	1198452.Jab_1c25760	1.109e-47	188.0	COG1418@1|root,COG1418@2|Bacteria	2|Bacteria	S	mRNA catabolic process	-	-	-	ko:K06950	-	-	-	-	ko00000	-	-	-	HD
SHD1_k127_1459931_7	379066.GAU_3347	6.126e-85	294.0	COG2362@1|root,COG2362@2|Bacteria	2|Bacteria	E	D-aminopeptidase	dppA	-	-	ko:K16203	-	-	-	-	ko00000,ko01000,ko01002	3.A.1.5.2	-	-	Peptidase_M55
SHD1_k127_1459931_0	379066.GAU_2322	7.041e-297	927.0	COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,1ZSS1@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	Tricorn protease homolog	-	-	-	ko:K08676	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ
SHD1_k127_1465246_2	1122991.BAIZ01000113_gene3011	3.752e-06	49.0	2E4EA@1|root,32Z9I@2|Bacteria,4NTWC@976|Bacteroidetes,2FU6R@200643|Bacteroidia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_1475419_1	1122223.KB890687_gene2687	1.25e-35	141.0	COG1167@1|root,COG1167@2|Bacteria,1WM9Y@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	K	helix_turn_helix gluconate operon transcriptional repressor	-	-	-	ko:K00375	-	-	-	-	ko00000,ko03000	-	-	-	Aminotran_1_2,GntR
SHD1_k127_1475419_0	502025.Hoch_5309	7.434e-256	800.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,42MMK@68525|delta/epsilon subdivisions,2WJC1@28221|Deltaproteobacteria,2YUAB@29|Myxococcales	28221|Deltaproteobacteria	S	ABC transporter	yjjK	-	3.6.3.25	ko:K06020	-	-	-	-	ko00000,ko01000	-	-	-	ABC_tran,ABC_tran_Xtn
SHD1_k127_149200_3	861299.J421_0983	7.751e-53	188.0	COG3153@1|root,COG3153@2|Bacteria,1ZUZD@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10
SHD1_k127_149200_5	1121926.AXWO01000040_gene4363	5.397e-23	101.0	2C82G@1|root,32RK9@2|Bacteria,2IRVD@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF4242)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4242
SHD1_k127_149200_2	713586.KB900536_gene2448	1.454e-62	226.0	COG0500@1|root,COG2226@2|Bacteria,1MXP4@1224|Proteobacteria,1S7AD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
SHD1_k127_149200_1	404589.Anae109_1600	1.118e-96	327.0	COG2207@1|root,COG2207@2|Bacteria,1N0FA@1224|Proteobacteria	1224|Proteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AraC_N,Cupin_6,HTH_18
SHD1_k127_149200_0	861299.J421_4080	2.25e-138	446.0	COG1801@1|root,COG1801@2|Bacteria	2|Bacteria	L	Protein of unknown function DUF72	MA20_09500	-	-	-	-	-	-	-	-	-	-	-	DUF72
SHD1_k127_149200_6	1189612.A33Q_2386	3.157e-13	78.0	COG4319@1|root,COG4319@2|Bacteria,4NUN7@976|Bacteroidetes,47WZP@768503|Cytophagia	976|Bacteroidetes	S	Domain of unknown function (DUF4440)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
SHD1_k127_149200_4	861299.J421_0700	1.398e-44	168.0	COG0454@1|root,COG1051@1|root,COG0456@2|Bacteria,COG1051@2|Bacteria	2|Bacteria	F	GDP-mannose mannosyl hydrolase activity	-	-	3.6.1.55,5.5.1.4	ko:K01858,ko:K03207,ko:K03574	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000,ko03400	-	-	-	NUDIX
SHD1_k127_1499581_2	861299.J421_2804	2.501e-93	316.0	COG0329@1|root,COG0329@2|Bacteria,1ZTGV@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Dihydrodipicolinate synthetase family	-	-	-	-	-	-	-	-	-	-	-	-	DHDPS
SHD1_k127_1499581_1	861299.J421_2799	1.077e-151	484.0	COG0180@1|root,COG0180@2|Bacteria,1ZT3P@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	tRNA synthetases class I (W and Y)	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
SHD1_k127_1499581_3	1379270.AUXF01000004_gene3006	1.953e-65	233.0	COG0483@1|root,COG0483@2|Bacteria,1ZTQA@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	Inositol monophosphatase family	-	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
SHD1_k127_1499581_0	861299.J421_2797	3.312e-194	631.0	COG3404@1|root,COG3643@1|root,COG3404@2|Bacteria,COG3643@2|Bacteria,1ZT04@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Formiminotransferase domain, N-terminal subdomain	-	-	2.1.2.5,4.3.1.4	ko:K13990	ko00340,ko00670,ko01100,map00340,map00670,map01100	-	R02287,R02302,R03189	RC00165,RC00221,RC00223,RC00688,RC00870	ko00000,ko00001,ko01000,ko03036,ko04147	-	-	-	FTCD,FTCD_C,FTCD_N
SHD1_k127_1505386_0	861299.J421_4200	2.461e-97	325.0	COG0596@1|root,COG0596@2|Bacteria,1ZTSU@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
SHD1_k127_1505386_3	861299.J421_4201	2.072e-22	101.0	2CA00@1|root,344QM@2|Bacteria,1ZU1Z@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_1505386_2	379066.GAU_2605	1.373e-35	144.0	COG0558@1|root,COG0558@2|Bacteria,1ZTUW@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	CDP-alcohol phosphatidyltransferase	-	-	2.7.8.41,2.7.8.5	ko:K00995,ko:K08744	ko00564,ko01100,map00564,map01100	-	R01801,R02030	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
SHD1_k127_1505386_1	1278073.MYSTI_02245	2.716e-36	151.0	COG0664@1|root,COG0664@2|Bacteria,1NBX3@1224|Proteobacteria,42UGQ@68525|delta/epsilon subdivisions,2WQY8@28221|Deltaproteobacteria,2YVI9@29|Myxococcales	28221|Deltaproteobacteria	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
SHD1_k127_1505386_6	861299.J421_4205	1.308e-14	78.0	2EY14@1|root,33RA2@2|Bacteria,1ZSR5@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_1519427_2	861299.J421_3453	6.973e-33	130.0	COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,1ZSPW@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KT	Sigma factor PP2C-like phosphatases	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	SpoIIE
SHD1_k127_1519427_0	861299.J421_3452	9.915e-88	302.0	COG0030@1|root,COG0030@2|Bacteria,1ZT2M@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
SHD1_k127_1519427_1	379066.GAU_1881	5.612e-76	259.0	COG2344@1|root,COG2344@2|Bacteria,1ZTJV@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Modulates transcription in response to changes in cellular NADH NAD( ) redox state	rex	-	-	ko:K01926	-	-	-	-	ko00000,ko03000	-	-	-	CoA_binding,Put_DNA-bind_N
SHD1_k127_1529094_7	861299.J421_3403	1.357e-17	90.0	COG0515@1|root,COG0515@2|Bacteria,1ZTE2@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
SHD1_k127_1529094_6	379066.GAU_1768	3.293e-19	92.0	2CIX3@1|root,2ZQU0@2|Bacteria,1ZU6D@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_1529094_3	861299.J421_3405	6.182e-97	338.0	COG0750@1|root,COG0750@2|Bacteria,1ZSKX@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	Peptidase family M50	-	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ,Peptidase_M50
SHD1_k127_1529094_0	861299.J421_3406	4.553e-155	500.0	COG0743@1|root,COG0743@2|Bacteria,1ZTFR@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	-	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	-	DXPR_C,DXP_redisom_C,DXP_reductoisom
SHD1_k127_1529094_5	861299.J421_3407	1.454e-69	248.0	COG4589@1|root,COG4589@2|Bacteria,1ZTGH@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Cytidylyltransferase family	-	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
SHD1_k127_1529094_1	861299.J421_3408	6.571e-113	370.0	COG0020@1|root,COG0020@2|Bacteria,1ZSNJ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	-	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
SHD1_k127_1529094_4	861299.J421_3409	8.102e-70	251.0	COG0233@1|root,COG0233@2|Bacteria,1ZTI2@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	-	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
SHD1_k127_1529094_2	1379270.AUXF01000006_gene121	8.789e-110	358.0	COG0528@1|root,COG0528@2|Bacteria,1ZSY2@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
SHD1_k127_1549425_3	861299.J421_3932	6.972e-52	192.0	28P8D@1|root,33QB6@2|Bacteria,1ZSQK@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	SusD family	-	-	-	ko:K21572	-	-	-	-	ko00000,ko02000	8.A.46.1,8.A.46.3	-	-	SusD_RagB
SHD1_k127_1549425_0	1379270.AUXF01000003_gene3454	3.229e-250	807.0	COG1629@1|root,COG4771@2|Bacteria,1ZT9M@142182|Gemmatimonadetes	142182|Gemmatimonadetes	P	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,Plug,TonB_dep_Rec
SHD1_k127_1549425_1	861299.J421_0180	5.014e-203	658.0	COG3590@1|root,COG3590@2|Bacteria	2|Bacteria	O	peptidase	-	-	3.4.24.71	ko:K01415,ko:K07386	-	-	-	-	ko00000,ko01000,ko01002,ko04147	-	-	-	Peptidase_M13,Peptidase_M13_N
SHD1_k127_1549425_5	379066.GAU_2745	1.189e-14	77.0	2CA9X@1|root,2ZJY8@2|Bacteria,1ZU1S@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_1549425_2	861299.J421_1569	2.297e-52	192.0	COG1970@1|root,COG1970@2|Bacteria,1ZTYT@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell	mscL	-	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
SHD1_k127_1549425_6	1395516.PMO01_20775	4.673e-06	49.0	COG1633@1|root,COG1633@2|Bacteria,1N4K6@1224|Proteobacteria	1224|Proteobacteria	S	Aldehyde dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	DUF2383
SHD1_k127_1549425_4	196367.JNFG01000032_gene8696	5.67e-30	123.0	COG1633@1|root,COG1633@2|Bacteria,1RGZG@1224|Proteobacteria,2VSVM@28216|Betaproteobacteria,1K16X@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Domain of unknown function (DUF2383)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2383
SHD1_k127_1584469_0	1267535.KB906767_gene3140	1.176e-198	623.0	COG1063@1|root,COG1063@2|Bacteria,3Y3UU@57723|Acidobacteria,2JI46@204432|Acidobacteriia	204432|Acidobacteriia	E	PFAM Alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_N_assoc,ADH_zinc_N
SHD1_k127_1584469_4	1121920.AUAU01000006_gene301	2.689e-41	161.0	2BYAB@1|root,32R2Z@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_1584469_3	1040989.AWZU01000028_gene3001	2.029e-103	349.0	COG1237@1|root,COG1237@2|Bacteria,1NK2I@1224|Proteobacteria,2TTSG@28211|Alphaproteobacteria,3JRZP@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	2.5.1.105	ko:K06897	ko00790,map00790	-	R10339	RC00121	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
SHD1_k127_1584469_5	861299.J421_6228	1.004e-27	115.0	COG1695@1|root,COG1695@2|Bacteria,1ZV8D@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
SHD1_k127_1584469_1	204669.Acid345_2047	2.945e-178	591.0	COG0577@1|root,COG0577@2|Bacteria,3Y6R1@57723|Acidobacteria,2JMKX@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
SHD1_k127_1584469_2	240015.ACP_2489	2.087e-157	520.0	28JZQ@1|root,2Z9PN@2|Bacteria,3Y4UW@57723|Acidobacteria,2JMX9@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_1587982_2	1379270.AUXF01000001_gene2735	1.459e-55	202.0	COG0845@1|root,COG0845@2|Bacteria,1ZU91@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	Biotin-lipoyl like	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
SHD1_k127_1587982_1	1379270.AUXF01000001_gene2736	4.602e-112	378.0	COG1538@1|root,COG1538@2|Bacteria,1ZUIX@142182|Gemmatimonadetes	142182|Gemmatimonadetes	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
SHD1_k127_1587982_0	864069.MicloDRAFT_00060470	0.0	1332.0	COG0178@1|root,COG0178@2|Bacteria,1MX79@1224|Proteobacteria,2TTXN@28211|Alphaproteobacteria,1JT9I@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate	-	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
SHD1_k127_1599237_0	861299.J421_0066	3.078e-305	955.0	COG0567@1|root,COG0567@2|Bacteria,1ZSVR@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	2-oxoglutarate dehydrogenase N-terminus	-	-	1.2.4.2	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
SHD1_k127_1599237_1	861299.J421_0065	2.442e-228	732.0	COG2120@1|root,COG2120@2|Bacteria,1ZT6U@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
SHD1_k127_1600934_0	861299.J421_3809	1.078e-143	463.0	COG0058@1|root,COG0058@2|Bacteria,1ZSZ3@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	Carbohydrate phosphorylase	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
SHD1_k127_1603780_0	861299.J421_3563	0.0	1035.0	COG0317@1|root,COG0317@2|Bacteria,1ZT5M@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	-	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
SHD1_k127_1614137_1	861299.J421_2845	1.328e-240	775.0	COG0823@1|root,COG4775@1|root,COG0823@2|Bacteria,COG4775@2|Bacteria,1ZSWP@142182|Gemmatimonadetes	142182|Gemmatimonadetes	MU	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	PD40
SHD1_k127_1614137_10	861299.J421_2846	2.125e-53	192.0	COG0663@1|root,COG0663@2|Bacteria,1ZTR9@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Bacterial transferase hexapeptide (six repeats)	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
SHD1_k127_1614137_0	861299.J421_2847	0.0	1386.0	COG0209@1|root,COG0209@2|Bacteria,1ZSU9@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_lgC,Ribonuc_red_lgN
SHD1_k127_1614137_7	861299.J421_3773	1.276e-77	285.0	COG5002@1|root,COG5002@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
SHD1_k127_1614137_5	1220583.GOACH_21_00670	3.748e-125	417.0	COG0477@1|root,COG0477@2|Bacteria,2GIUM@201174|Actinobacteria,4GBFR@85026|Gordoniaceae	201174|Actinobacteria	U	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SHD1_k127_1614137_12	1220534.B655_0285	7.956e-51	201.0	COG1502@1|root,arCOG02041@2157|Archaea	2157|Archaea	I	Phospholipase D Transphosphatidylase	-	-	-	ko:K06131,ko:K06132,ko:K06915	ko00564,ko01100,map00564,map01100	-	R07390,R11062	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2
SHD1_k127_1614137_8	1487921.DP68_16760	1.224e-60	214.0	COG0288@1|root,COG0288@2|Bacteria,1VSV8@1239|Firmicutes,24GE5@186801|Clostridia,36QPY@31979|Clostridiaceae	186801|Clostridia	P	carbonic anhydrase	-	-	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
SHD1_k127_1614137_4	234267.Acid_2224	1.441e-129	428.0	COG0624@1|root,COG0624@2|Bacteria,3Y7TX@57723|Acidobacteria	57723|Acidobacteria	E	Peptidase family M20/M25/M40	-	-	3.5.1.16	ko:K01438	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R00669,R09107	RC00064,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
SHD1_k127_1614137_9	861299.J421_0836	1.45e-53	205.0	COG3652@1|root,COG3652@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4142)	MA20_42090	-	-	ko:K08995	-	-	-	-	ko00000	-	-	-	DUF4142
SHD1_k127_1614137_11	861299.J421_0837	6.631e-53	195.0	COG2345@1|root,COG2345@2|Bacteria	2|Bacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_11,HTH_20,HTH_24,HTH_5,MarR_2
SHD1_k127_1614137_3	231434.JQJH01000006_gene18	2.181e-132	451.0	COG4993@1|root,COG4993@2|Bacteria,1MUW1@1224|Proteobacteria,2U2KU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ,PQQ_2
SHD1_k127_1614137_13	861299.J421_2336	8.246e-35	143.0	COG1993@1|root,COG1993@2|Bacteria	2|Bacteria	T	acr, cog1993	-	-	-	ko:K09137	-	-	-	-	ko00000	-	-	-	DUF190
SHD1_k127_1614137_14	861299.J421_2335	6.536e-27	115.0	COG0239@1|root,COG0239@2|Bacteria,1ZU3U@142182|Gemmatimonadetes	142182|Gemmatimonadetes	U	Important for reducing fluoride concentration in the cell, thus reducing its toxicity	crcB	-	-	ko:K06199	-	-	-	-	ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3	-	-	CRCB
SHD1_k127_1614137_6	1040982.AXAL01000022_gene6409	1.088e-77	271.0	COG2423@1|root,COG2423@2|Bacteria,1N3EI@1224|Proteobacteria,2TT7X@28211|Alphaproteobacteria,43HEM@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Ectoine utilization protein EutC	-	-	-	-	-	-	-	-	-	-	-	-	OCD_Mu_crystall
SHD1_k127_1614137_2	234267.Acid_1836	6.061e-156	499.0	COG0436@1|root,COG0436@2|Bacteria,3Y5AV@57723|Acidobacteria	57723|Acidobacteria	E	aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
SHD1_k127_1616066_1	767434.Fraau_1464	1.937e-12	69.0	COG4260@1|root,COG4260@2|Bacteria,1PB6V@1224|Proteobacteria,1SURY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	virion core protein, lumpy skin disease virus	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_1616066_0	1123371.ATXH01000003_gene1875	9.686e-38	162.0	COG4206@1|root,COG4206@2|Bacteria	2|Bacteria	H	cobalamin-transporting ATPase activity	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	CarbopepD_reg_2,Plug,TonB_dep_Rec
SHD1_k127_1617235_9	671143.DAMO_0096	1.797e-39	157.0	COG2232@1|root,COG2232@2|Bacteria	2|Bacteria	V	ATP-grasp domain	-	-	3.5.4.27	ko:K01499,ko:K06913	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03464	RC01870	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_3
SHD1_k127_1617235_6	886293.Sinac_1241	2.027e-60	231.0	COG1029@1|root,COG1029@2|Bacteria,2IYZN@203682|Planctomycetes	203682|Planctomycetes	C	formylmethanofuran dehydrogenase, subunit	-	-	1.2.7.12	ko:K00201	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	-
SHD1_k127_1617235_0	1380390.JIAT01000010_gene4326	7.28e-183	601.0	COG1229@1|root,COG1229@2|Bacteria	2|Bacteria	C	Formylmethanofuran dehydrogenase subunit A	fhcA	GO:0003674,GO:0003824,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016810,GO:0044237,GO:0044281	1.2.7.12	ko:K00200	ko00680,ko01100,ko01120,ko01130,ko01200,map00680,map01100,map01120,map01130,map01200	M00567	R03015,R08060	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_3
SHD1_k127_1617235_1	582744.Msip34_1508	3.159e-109	373.0	COG2037@1|root,COG2037@2|Bacteria,1MVSD@1224|Proteobacteria,2VJSP@28216|Betaproteobacteria,2KME8@206350|Nitrosomonadales	206350|Nitrosomonadales	C	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)	ffsA	-	2.3.1.101	ko:K00672	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03390	RC00197,RC00870,RC02881	ko00000,ko00001,ko00002,ko01000	-	-	-	FTR,FTR_C
SHD1_k127_1617235_7	1380390.JIAT01000010_gene4328	2.746e-49	196.0	COG2218@1|root,COG2218@2|Bacteria	2|Bacteria	C	formylmethanofuran dehydrogenase activity	fhcC	GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0044237,GO:0044281	1.2.7.12	ko:K00202	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060,R11743	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	GXGXG
SHD1_k127_1617235_2	1380390.JIAT01000010_gene4329	3.495e-91	310.0	COG3252@1|root,COG3252@2|Bacteria	2|Bacteria	H	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT	mch	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0009987,GO:0015947,GO:0016787,GO:0016810,GO:0016814,GO:0018759,GO:0019238,GO:0043446,GO:0044237,GO:0044424,GO:0044464,GO:0071704	3.5.4.27	ko:K01499	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03464	RC01870	ko00000,ko00001,ko00002,ko01000	-	-	-	MCH
SHD1_k127_1617235_13	983920.Y88_0262	1.503e-17	93.0	COG3224@1|root,COG3224@2|Bacteria,1N2DP@1224|Proteobacteria,2UBSR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	EthD domain	-	-	-	-	-	-	-	-	-	-	-	-	EthD
SHD1_k127_1617235_3	1380390.JIAT01000010_gene4336	7.97e-88	301.0	COG0189@1|root,COG0189@2|Bacteria,2HXBM@201174|Actinobacteria	201174|Actinobacteria	HJ	Belongs to the RimK family	rimK	-	6.3.2.43	ko:K05827,ko:K05844	ko00300,ko01100,ko01210,ko01230,map00300,map01100,map01210,map01230	M00031	R09775	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000,ko03009	-	-	-	RimK,TrkA_C
SHD1_k127_1617235_4	1380390.JIAT01000010_gene4323	4.611e-66	239.0	COG1767@1|root,COG1767@2|Bacteria,2H80Q@201174|Actinobacteria,4CTM7@84995|Rubrobacteria	84995|Rubrobacteria	H	ATP:dephospho-CoA triphosphoribosyl transferase	-	-	2.4.2.52	ko:K05966	ko02020,map02020	-	R09675	RC00049,RC00063	ko00000,ko00001,ko01000	-	-	-	CitG
SHD1_k127_1617235_10	1128421.JAGA01000003_gene3292	6.493e-39	151.0	COG0720@1|root,COG0720@2|Bacteria,2NR6T@2323|unclassified Bacteria	2|Bacteria	H	6-pyruvoyl tetrahydropterin synthase	-	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
SHD1_k127_1617235_8	886293.Sinac_1218	5.307e-42	164.0	COG0106@1|root,COG0106@2|Bacteria,2IZR7@203682|Planctomycetes	203682|Planctomycetes	E	Belongs to the HisA HisF family	-	-	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
SHD1_k127_1617235_5	1380390.JIAT01000010_gene4334	6.253e-62	226.0	COG1548@1|root,COG1548@2|Bacteria	2|Bacteria	GK	Hydantoinase/oxoprolinase	-	-	2.5.1.131	ko:K07072	ko00680,map00680	-	R11040	RC01372,RC03335	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_A
SHD1_k127_1617235_11	192952.MM_2512	8.034e-27	121.0	COG2054@1|root,arCOG00859@2157|Archaea,2XVEI@28890|Euryarchaeota,2N9QG@224756|Methanomicrobia	224756|Methanomicrobia	S	aspartate glutamate uridylate kinase	-	-	2.7.4.31	ko:K07144	ko00680,map00680	-	R11039	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
SHD1_k127_1617235_12	591167.Sfla_6110	6.313e-19	96.0	COG1891@1|root,COG1891@2|Bacteria,2HKMX@201174|Actinobacteria	201174|Actinobacteria	S	lyase activity	-	-	4.2.3.153	ko:K09733	ko00680,map00680	-	R10935	RC03315	ko00000,ko00001,ko01000	-	-	-	4HFCP_synth
SHD1_k127_161762_3	204669.Acid345_0330	2.482e-07	55.0	2DC00@1|root,2ZC4V@2|Bacteria,3Y8QE@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_161762_0	1101192.KB910516_gene93	3.071e-163	526.0	COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,2TRWK@28211|Alphaproteobacteria,1JT2Z@119045|Methylobacteriaceae	28211|Alphaproteobacteria	P	Acts as a magnesium transporter	mgtE	GO:0000287,GO:0003674,GO:0005488,GO:0005515,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0015693,GO:0030001,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0046872,GO:0046983,GO:0051179,GO:0051234,GO:0070838,GO:0072511	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
SHD1_k127_161762_1	290397.Adeh_3989	7.497e-110	370.0	COG2271@1|root,COG2271@2|Bacteria,1MWYR@1224|Proteobacteria,42RD4@68525|delta/epsilon subdivisions,2WN11@28221|Deltaproteobacteria,2YU83@29|Myxococcales	28221|Deltaproteobacteria	G	Organic Anion Transporter Polypeptide (OATP) family	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SHD1_k127_161762_2	391596.PBAL39_08440	2.39e-09	62.0	COG0730@1|root,COG0730@2|Bacteria,4NGP8@976|Bacteroidetes	976|Bacteroidetes	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
SHD1_k127_1620498_2	1379270.AUXF01000001_gene2817	4.833e-68	252.0	COG1463@1|root,COG1463@2|Bacteria,1ZTI5@142182|Gemmatimonadetes	142182|Gemmatimonadetes	Q	MlaD protein	-	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
SHD1_k127_1620498_1	379066.GAU_2574	2.936e-85	291.0	COG0767@1|root,COG0767@2|Bacteria,1ZSUC@142182|Gemmatimonadetes	142182|Gemmatimonadetes	Q	Permease MlaE	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
SHD1_k127_1620498_0	861299.J421_4163	6.679e-116	392.0	COG0795@1|root,COG0795@2|Bacteria,1ZSNM@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Predicted permease YjgP/YjgQ family	-	-	-	ko:K11720	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
SHD1_k127_1620498_3	861299.J421_4162	4.171e-36	143.0	COG0795@1|root,COG0795@2|Bacteria,1ZTJR@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Predicted permease YjgP/YjgQ family	-	-	-	ko:K07091	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
SHD1_k127_1625330_8	1254432.SCE1572_37735	3.91e-12	67.0	COG2010@1|root,COG2010@2|Bacteria,1QX4J@1224|Proteobacteria,43CNY@68525|delta/epsilon subdivisions,2X7W8@28221|Deltaproteobacteria,2YX21@29|Myxococcales	28221|Deltaproteobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cu2_monoox_C,Cu2_monooxygen
SHD1_k127_1625330_7	861299.J421_2900	3.519e-22	97.0	COG0577@1|root,COG0577@2|Bacteria,1ZUN6@142182|Gemmatimonadetes	142182|Gemmatimonadetes	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
SHD1_k127_1625330_4	765912.Thimo_1129	3.827e-65	239.0	COG2267@1|root,COG2267@2|Bacteria,1QUW0@1224|Proteobacteria,1T3KF@1236|Gammaproteobacteria,1WWZF@135613|Chromatiales	135613|Chromatiales	I	Alpha beta hydrolase	-	-	-	ko:K06049	-	-	-	-	ko00000	-	-	-	Abhydrolase_6
SHD1_k127_1625330_3	861299.J421_2896	1.248e-113	370.0	COG2120@1|root,COG2120@2|Bacteria,1ZTDK@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	GlcNAc-PI de-N-acetylase	-	-	-	ko:K01463	-	-	-	-	ko00000,ko01000	-	-	-	PIG-L
SHD1_k127_1625330_0	861299.J421_2988	5.945e-277	878.0	COG0457@1|root,COG0659@1|root,COG0457@2|Bacteria,COG0659@2|Bacteria	2|Bacteria	P	secondary active sulfate transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_1625330_2	861299.J421_2892	9.127e-154	494.0	COG1104@1|root,COG1104@2|Bacteria,1ZSXD@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Aminotransferase class-V	-	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
SHD1_k127_1625330_1	861299.J421_2891	1.409e-182	576.0	COG0482@1|root,COG0482@2|Bacteria,1ZST7@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
SHD1_k127_1625330_5	1122604.JONR01000003_gene1383	1.171e-30	125.0	COG0346@1|root,COG0346@2|Bacteria,1RHRF@1224|Proteobacteria,1S7BW@1236|Gammaproteobacteria,1X8Q3@135614|Xanthomonadales	135614|Xanthomonadales	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
SHD1_k127_1625330_6	485913.Krac_5471	7.41e-29	121.0	COG1846@1|root,COG1846@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
SHD1_k127_1645370_1	635013.TherJR_1012	2.844e-49	189.0	COG4277@1|root,COG4277@2|Bacteria,1TRT2@1239|Firmicutes,247UD@186801|Clostridia,261DR@186807|Peptococcaceae	186801|Clostridia	S	DNA modification repair radical SAM protein	-	-	-	-	-	-	-	-	-	-	-	-	HHH_3,Radical_SAM
SHD1_k127_1645370_0	861299.J421_3834	4.24e-83	284.0	COG4783@1|root,COG4783@2|Bacteria,1ZSU4@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
SHD1_k127_1645370_2	1449076.JOOE01000004_gene70	8.449e-44	163.0	COG1793@1|root,COG1793@2|Bacteria,1R4SI@1224|Proteobacteria,2U213@28211|Alphaproteobacteria,2K3AE@204457|Sphingomonadales	204457|Sphingomonadales	L	ATP dependent DNA ligase C terminal region	-	-	-	-	-	-	-	-	-	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M
SHD1_k127_165909_1	1379270.AUXF01000005_gene820	8.555e-189	601.0	COG0195@1|root,COG0195@2|Bacteria,1ZSNN@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	HHH_5,KH_5,NusA_N
SHD1_k127_165909_3	1379270.AUXF01000005_gene819	6.519e-48	177.0	COG0779@1|root,COG0779@2|Bacteria,1ZTX3@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Required for maturation of 30S ribosomal subunits	rimP	-	-	ko:K09748	-	-	-	-	ko00000,ko03009	-	-	-	DUF150,DUF150_C
SHD1_k127_165909_2	861299.J421_3184	6.998e-75	259.0	COG1496@1|root,COG1496@2|Bacteria,1ZTTT@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Multi-copper polyphenol oxidoreductase laccase	-	-	-	ko:K05810	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_4
SHD1_k127_165909_0	319003.Bra1253DRAFT_04822	3.181e-205	647.0	COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,2TRPH@28211|Alphaproteobacteria,3JVEC@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
SHD1_k127_1664739_0	1144275.COCOR_00125	9.148e-180	578.0	COG0578@1|root,COG0578@2|Bacteria,1MUMY@1224|Proteobacteria,42N1B@68525|delta/epsilon subdivisions,2WJWS@28221|Deltaproteobacteria,2YTWC@29|Myxococcales	28221|Deltaproteobacteria	C	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family	glpD	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,DAO_C
SHD1_k127_1664739_5	861299.J421_0057	8.656e-63	220.0	COG0782@1|root,COG0782@2|Bacteria,1ZTPD@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Transcription elongation factor, N-terminal	-	-	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
SHD1_k127_1664739_1	251221.35211608	3.604e-165	530.0	COG1899@1|root,COG1899@2|Bacteria,1G448@1117|Cyanobacteria	1117|Cyanobacteria	O	Belongs to the deoxyhypusine synthase family	-	-	2.5.1.46	ko:K00809	-	-	-	-	ko00000,ko01000	-	-	-	DS
SHD1_k127_1664739_3	861299.J421_0058	1.162e-118	389.0	COG1611@1|root,COG1611@2|Bacteria,1ZT7E@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Possible lysine decarboxylase	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
SHD1_k127_1664739_2	861299.J421_0060	6.918e-153	497.0	COG1524@1|root,COG1524@2|Bacteria,1ZT33@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
SHD1_k127_1664739_6	861299.J421_2311	1.261e-27	115.0	2FKCY@1|root,34C0C@2|Bacteria,1ZU3I@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_1664739_4	379066.GAU_2868	1.929e-111	369.0	COG1600@1|root,COG1600@2|Bacteria,1ZU4X@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)	-	-	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1730,Fer4_16
SHD1_k127_1664739_8	103733.JNYO01000003_gene8233	8.611e-05	53.0	COG5563@1|root,COG5563@2|Bacteria,2GRWY@201174|Actinobacteria,4EF2Q@85010|Pseudonocardiales	201174|Actinobacteria	S	FG-GAP repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_1665588_5	383372.Rcas_3083	3.865e-42	159.0	COG0677@1|root,COG0677@2|Bacteria,2G5PP@200795|Chloroflexi,3756K@32061|Chloroflexia	32061|Chloroflexia	M	PFAM UDP-glucose GDP-mannose dehydrogenase	-	-	1.1.1.136	ko:K13015	ko00520,map00520	-	R00421	RC00291	ko00000,ko00001,ko01000,ko01005	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
SHD1_k127_1665588_1	1379270.AUXF01000003_gene3890	2.108e-162	518.0	COG0673@1|root,COG0673@2|Bacteria,1ZSQ4@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	1.1.1.335	ko:K13020	ko00520,map00520	-	R10140	RC00182	ko00000,ko00001,ko01000,ko01005	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
SHD1_k127_1665588_4	931276.Cspa_c55380	9.244e-70	257.0	COG0110@1|root,COG0110@2|Bacteria,1TT21@1239|Firmicutes,24CCH@186801|Clostridia,36UQH@31979|Clostridiaceae	186801|Clostridia	S	Hexapeptide repeat of succinyl-transferase	wbpD	-	2.3.1.201	ko:K13018	ko00520,map00520	-	R10100	RC00004,RC00166	ko00000,ko00001,ko01000,ko01005	-	-	-	Hexapep,Hexapep_2
SHD1_k127_1665588_0	886293.Sinac_0915	1.324e-183	586.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	yhjX	-	-	ko:K08177	-	-	-	-	ko00000,ko02000	2.A.1.11	-	-	MFS_1
SHD1_k127_1665588_2	497964.CfE428DRAFT_6191	3.051e-94	322.0	28JQV@1|root,2Z7R2@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_1665588_3	1279009.ADICEAN_01013	6.621e-79	282.0	2DBA6@1|root,2Z814@2|Bacteria,4NFI6@976|Bacteroidetes,47MPW@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_1668435_2	379066.GAU_1993	3.238e-43	162.0	COG0508@1|root,COG0508@2|Bacteria,1ZT7I@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	2-oxoacid dehydrogenases acyltransferase (catalytic domain)	-	-	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
SHD1_k127_1668435_5	379066.GAU_1994	1.954e-06	56.0	293YK@1|root,2ZRDM@2|Bacteria,1ZU6Y@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_1668435_0	861299.J421_3597	5.328e-180	569.0	COG0022@1|root,COG0022@2|Bacteria,1ZT89@142182|Gemmatimonadetes	2|Bacteria	C	Transketolase, pyrimidine binding domain	bfmBA	-	1.2.4.4	ko:K00167,ko:K11381,ko:K21417	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,Transket_pyr,Transketolase_C
SHD1_k127_1668435_1	861299.J421_3598	1.914e-176	558.0	COG1071@1|root,COG1071@2|Bacteria,1ZT5G@142182|Gemmatimonadetes	2|Bacteria	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	bfmBA	-	1.2.4.1,1.2.4.4	ko:K00161,ko:K11381,ko:K21416	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,Transket_pyr,Transketolase_C
SHD1_k127_1668435_3	379066.GAU_1995	2.769e-32	127.0	2FD8C@1|root,345AC@2|Bacteria,1ZTXK@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_1668435_4	1379270.AUXF01000003_gene3860	1.415e-09	61.0	296W8@1|root,2ZU51@2|Bacteria,1ZU4Z@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_1669691_3	379066.GAU_0171	5.974e-42	160.0	COG0793@1|root,COG0793@2|Bacteria,1ZT92@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	tail specific protease	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_S41
SHD1_k127_1669691_4	1396141.BATP01000051_gene3338	1.253e-16	81.0	2EKH8@1|root,33E79@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_1669691_2	379066.GAU_0172	1.485e-108	359.0	COG5534@1|root,COG5534@2|Bacteria,1ZTEX@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	Replication initiator protein A	-	-	-	-	-	-	-	-	-	-	-	-	RPA
SHD1_k127_1669691_1	861299.J421_0459	9.626e-132	436.0	COG1502@1|root,COG1502@2|Bacteria,1ZTU6@142182|Gemmatimonadetes	2|Bacteria	I	Phospholipase D. Active site motifs.	cls	-	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2
SHD1_k127_1669691_0	861299.J421_1403	0.0	1143.0	COG1201@1|root,COG1201@2|Bacteria,1ZTN1@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	DEAD/H associated	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
SHD1_k127_1678431_3	216591.BCAL0736	1.382e-22	100.0	COG1080@1|root,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,2VH9N@28216|Betaproteobacteria,1JZP5@119060|Burkholderiaceae	28216|Betaproteobacteria	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	ptsI	-	2.7.3.9	ko:K08483	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	8.A.7	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
SHD1_k127_1678431_2	159087.Daro_4083	4.447e-36	140.0	COG1925@1|root,COG1925@2|Bacteria,1N6RM@1224|Proteobacteria,2VU8W@28216|Betaproteobacteria,2KWVF@206389|Rhodocyclales	206389|Rhodocyclales	G	Phosphotransferase System	ptsH	-	-	ko:K11189	-	-	-	-	ko00000,ko02000	4.A.2.1	-	-	PTS-HPr
SHD1_k127_1678431_1	305700.B447_01896	5.133e-45	167.0	COG2893@1|root,COG2893@2|Bacteria,1RHH7@1224|Proteobacteria,2VT9I@28216|Betaproteobacteria,2KWTC@206389|Rhodocyclales	206389|Rhodocyclales	G	Phosphotransferase system, mannose fructose-specific component IIA	ptsL	-	2.7.1.194	ko:K02821	ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060	M00283,M00550	R07671	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.7.1	-	-	EIIA-man
SHD1_k127_1678431_0	76114.ebA2546	1.165e-97	323.0	COG0189@1|root,COG0189@2|Bacteria,1MVUA@1224|Proteobacteria,2VIZ3@28216|Betaproteobacteria,2KUJJ@206389|Rhodocyclales	206389|Rhodocyclales	H	Belongs to the prokaryotic GSH synthase family	gshB	-	6.3.2.3	ko:K01920	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00497,R10994	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	GSH-S_ATP,GSH-S_N
SHD1_k127_1683451_2	395495.Lcho_1402	1.423e-32	131.0	COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,2VJ9Y@28216|Betaproteobacteria,1KM60@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	Two component transcriptional regulator, LuxR family	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
SHD1_k127_1683451_0	56780.SYN_01954	3.406e-58	222.0	COG4585@1|root,COG4585@2|Bacteria,1MWPN@1224|Proteobacteria,42RUN@68525|delta/epsilon subdivisions,2WNJZ@28221|Deltaproteobacteria,2MR4S@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE4,HAMP,HATPase_c,HisKA_3,PAS_3,PAS_4,PAS_9
SHD1_k127_1683451_1	1185876.BN8_01697	1.217e-46	177.0	COG2931@1|root,COG2931@2|Bacteria,4P26M@976|Bacteroidetes,47TC4@768503|Cytophagia	976|Bacteroidetes	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_1698140_0	861299.J421_3906	1.357e-130	421.0	COG0043@1|root,COG0043@2|Bacteria,1ZSMS@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	3-octaprenyl-4-hydroxybenzoate carboxy-lyase	-	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
SHD1_k127_1698140_1	861299.J421_3907	2.342e-95	317.0	COG0500@1|root,COG2226@2|Bacteria,1ZSNE@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)	menG	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
SHD1_k127_1698140_2	861299.J421_3908	7.471e-94	310.0	COG1595@1|root,COG1595@2|Bacteria,1ZT3B@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	ECF sigma factor	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
SHD1_k127_1698140_3	861299.J421_3909	4.36e-45	171.0	2F9A9@1|root,341MC@2|Bacteria,1ZU0R@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_1698140_4	861299.J421_3910	2.844e-39	160.0	COG1664@1|root,COG1664@2|Bacteria	2|Bacteria	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
SHD1_k127_1698140_5	861299.J421_3911	1.043e-29	127.0	COG4758@1|root,COG4758@2|Bacteria	2|Bacteria	KT	membrane	yvqF	-	-	ko:K11622	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	DUF2154
SHD1_k127_1699028_6	1210884.HG799463_gene9891	6.093e-30	126.0	COG0454@1|root,COG0456@2|Bacteria,2J1K9@203682|Planctomycetes	203682|Planctomycetes	K	acetyltransferase	-	-	-	ko:K03827	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_10
SHD1_k127_1699028_4	2074.JNYD01000002_gene5404	1.671e-37	148.0	COG0454@1|root,COG2764@1|root,COG0456@2|Bacteria,COG2764@2|Bacteria,2II3I@201174|Actinobacteria,4E680@85010|Pseudonocardiales	201174|Actinobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_7
SHD1_k127_1699028_7	682795.AciX8_4074	7.369e-24	108.0	COG1359@1|root,COG1359@2|Bacteria,3Y5IV@57723|Acidobacteria,2JNI6@204432|Acidobacteriia	204432|Acidobacteriia	S	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_1699028_3	743722.Sph21_4183	1.394e-42	163.0	COG2259@1|root,COG2259@2|Bacteria,4NUJY@976|Bacteroidetes,1ITNY@117747|Sphingobacteriia	976|Bacteroidetes	S	DoxX	-	-	-	-	-	-	-	-	-	-	-	-	DoxX
SHD1_k127_1699028_0	1121377.KB906436_gene921	8.075e-196	641.0	COG2909@1|root,COG2909@2|Bacteria	2|Bacteria	K	trisaccharide binding	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
SHD1_k127_1699028_1	861299.J421_0339	3.064e-193	624.0	COG2303@1|root,COG2303@2|Bacteria	2|Bacteria	E	choline dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N
SHD1_k127_1699028_8	1500890.JQNL01000001_gene1887	5.689e-07	59.0	2DB8V@1|root,2Z7SX@2|Bacteria,1MX06@1224|Proteobacteria,1RQ6Y@1236|Gammaproteobacteria,1X7CN@135614|Xanthomonadales	135614|Xanthomonadales	S	Gluconate 2-dehydrogenase subunit 3	-	-	1.1.99.3	ko:K06152	ko00030,ko01100,ko01120,map00030,map01100,map01120	-	R01741	RC00084	ko00000,ko00001,ko01000	-	-	-	Gluconate_2-dh3
SHD1_k127_1699028_5	379066.GAU_2956	2.458e-37	144.0	COG0662@1|root,COG0662@2|Bacteria,1ZVA1@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
SHD1_k127_1699028_2	1267535.KB906767_gene2868	3.521e-137	447.0	COG2132@1|root,COG2132@2|Bacteria	2|Bacteria	Q	Multicopper oxidase	aniA	-	1.7.2.1	ko:K00368	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000	-	-	-	Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3,Cupredoxin_1
SHD1_k127_1699028_9	861299.J421_0408	4.389e-05	46.0	2E3MN@1|root,32NV6@2|Bacteria,1ZV65@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Cytochrome C and Quinol oxidase polypeptide I	-	-	-	-	-	-	-	-	-	-	-	-	COX1
SHD1_k127_17069_2	395493.BegalDRAFT_0025	6.316e-10	66.0	COG0607@1|root,COG0607@2|Bacteria,1R71B@1224|Proteobacteria,1S2D9@1236|Gammaproteobacteria,4637I@72273|Thiotrichales	72273|Thiotrichales	KP	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
SHD1_k127_17069_1	497964.CfE428DRAFT_1821	3.234e-54	198.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	NHL
SHD1_k127_17069_0	861299.J421_0626	6.712e-90	299.0	COG2819@1|root,COG2819@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on ester bonds	-	-	-	ko:K07017	-	-	-	-	ko00000	-	-	-	Esterase
SHD1_k127_1713719_0	502025.Hoch_5309	1.008e-172	557.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,42MMK@68525|delta/epsilon subdivisions,2WJC1@28221|Deltaproteobacteria,2YUAB@29|Myxococcales	28221|Deltaproteobacteria	S	ABC transporter	yjjK	-	3.6.3.25	ko:K06020	-	-	-	-	ko00000,ko01000	-	-	-	ABC_tran,ABC_tran_Xtn
SHD1_k127_1713719_3	62928.azo2614	4.381e-40	153.0	2E5ES@1|root,3306N@2|Bacteria,1N5VN@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_1713719_1	861299.J421_1395	2.295e-155	508.0	COG2234@1|root,COG2234@2|Bacteria,1ZSXY@142182|Gemmatimonadetes	2|Bacteria	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
SHD1_k127_1713719_2	751945.Theos_0371	2.97e-55	197.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1WI6E@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
SHD1_k127_1724019_0	861299.J421_1484	4.139e-228	737.0	COG0577@1|root,COG0577@2|Bacteria	861299.J421_1484|-	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_1724019_1	861299.J421_0639	1.797e-31	126.0	COG1695@1|root,COG1695@2|Bacteria	2|Bacteria	K	negative regulation of transcription, DNA-templated	-	-	-	-	-	-	-	-	-	-	-	-	PadR
SHD1_k127_1724019_2	1123514.KB905903_gene383	1.173e-10	70.0	COG2885@1|root,COG2885@2|Bacteria,1REH1@1224|Proteobacteria,1S4WV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	DUF4398,OmpA
SHD1_k127_1727529_0	861299.J421_1368	5.887e-92	323.0	COG0312@1|root,COG0312@2|Bacteria,1ZSYW@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Putative modulator of DNA gyrase	-	-	-	-	-	-	-	-	-	-	-	-	PmbA_TldD
SHD1_k127_1727529_1	1379270.AUXF01000002_gene1735	2.795e-05	50.0	COG0312@1|root,COG0312@2|Bacteria,1ZSUE@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Putative modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD,TAT_signal
SHD1_k127_172841_4	861299.J421_3110	1.568e-24	104.0	COG0018@1|root,COG0018@2|Bacteria,1ZT6E@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Arginyl tRNA synthetase N terminal dom	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
SHD1_k127_172841_1	1379270.AUXF01000005_gene720	2.229e-148	476.0	COG0524@1|root,COG0524@2|Bacteria,1ZSUT@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
SHD1_k127_172841_0	1379270.AUXF01000005_gene721	8.333e-151	484.0	COG0150@1|root,COG0150@2|Bacteria,1ZSQJ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	AIR synthase related protein, C-terminal domain	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
SHD1_k127_172841_3	861299.J421_3113	1.513e-64	235.0	2F30H@1|root,33VVT@2|Bacteria,1ZTRF@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_172841_2	861299.J421_3114	1.711e-107	357.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1ZSNI@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	-	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
SHD1_k127_172898_6	1379270.AUXF01000004_gene3139	3.064e-66	233.0	COG0612@1|root,COG0612@2|Bacteria,1ZT1M@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Insulinase (Peptidase family M16)	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
SHD1_k127_172898_3	1297742.A176_02167	5.893e-132	438.0	COG0624@1|root,COG0624@2|Bacteria,1MWJS@1224|Proteobacteria,42STW@68525|delta/epsilon subdivisions,2WPBB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Peptidase dimerisation domain	-	-	-	ko:K13049	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
SHD1_k127_172898_2	861299.J421_2456	1.326e-134	469.0	COG1300@1|root,COG1714@1|root,COG1300@2|Bacteria,COG1714@2|Bacteria	2|Bacteria	S	RDD family	-	-	-	ko:K06384	-	-	-	-	ko00000	-	-	-	RDD,SpoIIM
SHD1_k127_172898_1	861299.J421_2457	1.604e-138	454.0	COG1721@1|root,COG1721@2|Bacteria	2|Bacteria	E	protein (some members contain a von Willebrand factor type A (vWA) domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,DUF58
SHD1_k127_172898_4	457425.XNR_1900	3.616e-102	344.0	COG0714@1|root,COG0714@2|Bacteria,2GK07@201174|Actinobacteria	201174|Actinobacteria	S	associated with various cellular activities	moxR2	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
SHD1_k127_172898_5	379066.GAU_0824	6.724e-86	290.0	COG1194@1|root,COG1194@2|Bacteria,1ZTNM@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	FES	-	-	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
SHD1_k127_172898_10	1151061.CAJY01000024_gene3204	1.012e-05	59.0	COG5373@1|root,COG5373@2|Bacteria,2GJII@201174|Actinobacteria	201174|Actinobacteria	D	Predicted membrane protein (DUF2339)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2339
SHD1_k127_172898_8	861299.J421_3990	4.383e-32	144.0	COG1186@1|root,COG1186@2|Bacteria,1ZTZD@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	RF-1 domain	-	-	-	ko:K15034	-	-	-	-	ko00000,ko03012	-	-	-	RF-1
SHD1_k127_172898_0	861299.J421_3989	8.352e-177	566.0	COG1253@1|root,COG1253@2|Bacteria,1ZT0D@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Transporter associated domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
SHD1_k127_1729764_1	861299.J421_0502	1.222e-60	217.0	COG1051@1|root,COG1051@2|Bacteria	2|Bacteria	F	GDP-mannose mannosyl hydrolase activity	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
SHD1_k127_1729764_0	1379270.AUXF01000004_gene2878	1.281e-163	538.0	COG1472@1|root,COG1472@2|Bacteria,1ZTD2@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	Glycosyl hydrolase family 3 C-terminal domain	-	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3,Glyco_hydro_3_C
SHD1_k127_1729764_2	379066.GAU_0167	2.411e-44	162.0	COG2924@1|root,COG2924@2|Bacteria,1ZTWZ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes	-	-	-	-	-	-	-	-	-	-	-	-	Iron_traffic
SHD1_k127_1737208_7	379066.GAU_0599	3.706e-39	156.0	COG0277@1|root,COG0277@2|Bacteria,1ZTRC@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	FAD binding domain	-	-	-	ko:K11472	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	FAD_binding_4
SHD1_k127_1737208_0	861299.J421_2525	9.722e-199	631.0	COG0277@1|root,COG0277@2|Bacteria,1ZT11@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	FAD linked oxidases, C-terminal domain	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
SHD1_k127_1737208_1	1379270.AUXF01000004_gene3283	1.514e-154	493.0	COG0568@1|root,COG0568@2|Bacteria,1ZSNB@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
SHD1_k127_1737208_4	861299.J421_2532	1.043e-107	363.0	COG0337@1|root,COG0337@2|Bacteria,1ZSS5@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	4.2.3.4	ko:K01735	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03083	RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase
SHD1_k127_1737208_5	861299.J421_2533	3.53e-81	273.0	COG2096@1|root,COG2096@2|Bacteria,1ZT4I@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Cobalamin adenosyltransferase	-	-	2.5.1.17	ko:K00798	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	Cob_adeno_trans
SHD1_k127_1737208_6	1242864.D187_002692	3.897e-61	224.0	COG0515@1|root,COG0515@2|Bacteria,1PJRR@1224|Proteobacteria	1224|Proteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PEGA,Pkinase
SHD1_k127_1737208_2	379066.GAU_0605	5.677e-150	484.0	COG0492@1|root,COG0492@2|Bacteria,1ZSM1@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.18.1.2,1.19.1.1	ko:K21567	-	-	-	-	ko00000,ko01000	-	-	-	Pyr_redox_2
SHD1_k127_1737208_3	479434.Sthe_1229	2.007e-145	478.0	COG2197@1|root,COG2197@2|Bacteria	2|Bacteria	K	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE
SHD1_k127_174829_12	861299.J421_3944	4.748e-07	56.0	COG0712@1|root,COG0712@2|Bacteria,1ZTP8@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	-	-	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	OSCP
SHD1_k127_174829_7	861299.J421_3945	8.025e-49	184.0	COG0711@1|root,COG0711@2|Bacteria,1ZTPY@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	atpF	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
SHD1_k127_174829_9	379066.GAU_2489	5.705e-21	95.0	COG0636@1|root,COG0636@2|Bacteria,1ZU1W@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpE	-	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_C
SHD1_k127_174829_3	1379270.AUXF01000003_gene3427	4.85e-107	355.0	COG0356@1|root,COG0356@2|Bacteria,1ZSQ5@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
SHD1_k127_174829_10	861299.J421_3948	1.098e-17	90.0	2FD0A@1|root,3452X@2|Bacteria,1ZU1X@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_174829_11	861299.J421_3949	2.695e-12	71.0	2DFBE@1|root,2ZR6K@2|Bacteria,1ZU7V@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter	-	-	-	-	-	-	-	-	-	-	-	-	ATPase_gene1
SHD1_k127_174829_8	379066.GAU_2493	1.21e-32	133.0	29X7H@1|root,30IWR@2|Bacteria,1ZTYC@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Intracellular proteinase inhibitor	-	-	-	-	-	-	-	-	-	-	-	-	BsuPI
SHD1_k127_174829_1	861299.J421_3951	1.146e-147	475.0	COG0714@1|root,COG0714@2|Bacteria,1ZT5U@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
SHD1_k127_174829_0	1379270.AUXF01000005_gene555	1.773e-152	512.0	COG2091@1|root,COG2091@2|Bacteria	2|Bacteria	H	lysine biosynthetic process via aminoadipic acid	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
SHD1_k127_174829_5	935557.ATYB01000009_gene596	1.772e-90	310.0	COG4275@1|root,COG4275@2|Bacteria,1MYDE@1224|Proteobacteria,2TV61@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Chromate resistance exported protein	-	-	-	-	-	-	-	-	-	-	-	-	Chrome_Resist
SHD1_k127_174829_6	861299.J421_1375	2.363e-75	256.0	COG4275@1|root,COG4275@2|Bacteria	2|Bacteria	S	Chromate resistance exported protein	-	-	-	-	-	-	-	-	-	-	-	-	Chrome_Resist
SHD1_k127_174829_4	861299.J421_2120	4.527e-101	338.0	COG1388@1|root,COG1388@2|Bacteria	2|Bacteria	M	LysM domain	eaeH	GO:0005575,GO:0005623,GO:0007155,GO:0008150,GO:0009279,GO:0009405,GO:0009987,GO:0016020,GO:0019867,GO:0022610,GO:0030260,GO:0030312,GO:0030313,GO:0031589,GO:0031975,GO:0042710,GO:0043708,GO:0044403,GO:0044409,GO:0044419,GO:0044462,GO:0044464,GO:0044764,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0071944,GO:0090605	-	ko:K13735	ko05100,map05100	-	-	-	ko00000,ko00001	-	-	-	Amidase_2,Big_1,CW_7,DUF1529,DUF928,IAT_beta,Invasin_D3,LysM
SHD1_k127_174829_2	861299.J421_1934	1.837e-117	389.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_1756753_1	671143.DAMO_2610	1.14e-17	85.0	COG0160@1|root,COG0160@2|Bacteria,2NNRV@2323|unclassified Bacteria	2|Bacteria	E	Aminotransferase class-III	gabT	-	2.6.1.19,2.6.1.22,2.6.1.33,2.6.1.36	ko:K03918,ko:K07250,ko:K20428	ko00250,ko00280,ko00410,ko00525,ko00640,ko00650,ko01100,ko01120,ko01130,map00250,map00280,map00410,map00525,map00640,map00650,map01100,map01120,map01130	M00027	R00457,R00908,R01648,R02773,R04188	RC00006,RC00062,RC00160,RC00781	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
SHD1_k127_1756753_0	671143.DAMO_2609	6.087e-38	156.0	COG0673@1|root,COG0673@2|Bacteria,2NREF@2323|unclassified Bacteria	2|Bacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
SHD1_k127_1756753_2	1122137.AQXF01000003_gene2094	1.694e-09	61.0	COG0823@1|root,COG0823@2|Bacteria,1MWYK@1224|Proteobacteria,2VGDT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	U	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	PD40
SHD1_k127_1759674_0	861299.J421_4378	8.599e-51	186.0	COG3595@1|root,COG3595@2|Bacteria,1ZTQ0@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097
SHD1_k127_1759674_2	861299.J421_4379	1.427e-30	132.0	COG3595@1|root,COG3595@2|Bacteria,1ZTQ0@142182|Gemmatimonadetes	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097,PA14
SHD1_k127_1759674_3	573064.Mefer_0998	3.752e-10	66.0	arCOG08243@1|root,arCOG08243@2157|Archaea,2Y4D8@28890|Euryarchaeota,23RR2@183939|Methanococci	183939|Methanococci	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_1759674_1	107635.AZUO01000001_gene233	8.107e-36	143.0	COG1670@1|root,COG1670@2|Bacteria,1QW54@1224|Proteobacteria,2TWMW@28211|Alphaproteobacteria,36Z07@31993|Methylocystaceae	28211|Alphaproteobacteria	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_4
SHD1_k127_1759674_4	861299.J421_0718	1.141e-06	55.0	2F4AY@1|root,33X1J@2|Bacteria,1ZTWF@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_176008_19	379066.GAU_0621	2.944e-16	79.0	COG0036@1|root,COG0036@2|Bacteria,1ZSP8@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	Ribulose-phosphate 3 epimerase family	-	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
SHD1_k127_176008_11	379066.GAU_0620	1.558e-61	219.0	COG0526@1|root,COG0526@2|Bacteria,1ZTMM@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	Glutathione peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
SHD1_k127_176008_3	861299.J421_2560	1.208e-141	458.0	COG0533@1|root,COG0533@2|Bacteria,1ZT0P@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
SHD1_k127_176008_7	861299.J421_2559	1.832e-92	312.0	COG0682@1|root,COG0682@2|Bacteria,1ZSYY@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
SHD1_k127_176008_16	861299.J421_4388	1.143e-39	154.0	COG3019@1|root,COG3019@2|Bacteria,1ZTWW@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Protein of unknown function, DUF	-	-	-	-	-	-	-	-	-	-	-	-	DUF411
SHD1_k127_176008_2	402881.Plav_0603	3.227e-143	466.0	COG2072@1|root,COG2072@2|Bacteria,1MUQH@1224|Proteobacteria,2TTY2@28211|Alphaproteobacteria,1JPCF@119043|Rhodobiaceae	28211|Alphaproteobacteria	C	Flavin-binding monooxygenase-like	-	-	-	-	-	-	-	-	-	-	-	-	FMO-like
SHD1_k127_176008_5	240015.ACP_1210	2.815e-116	387.0	COG0672@1|root,COG0672@2|Bacteria,3Y78C@57723|Acidobacteria,2JKXR@204432|Acidobacteriia	204432|Acidobacteriia	P	Iron permease FTR1 family	-	-	-	ko:K07243	-	-	-	-	ko00000,ko02000	2.A.108.1,2.A.108.2	-	-	FTR1
SHD1_k127_176008_18	1121439.dsat_1590	4.145e-20	102.0	COG0736@1|root,COG0736@2|Bacteria,1MZBF@1224|Proteobacteria,42TWY@68525|delta/epsilon subdivisions,2WRSQ@28221|Deltaproteobacteria,2MCER@213115|Desulfovibrionales	28221|Deltaproteobacteria	I	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein	acpS	-	2.7.8.7	ko:K00997	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
SHD1_k127_176008_17	861299.J421_2554	9e-23	108.0	290CD@1|root,2ZN1W@2|Bacteria,1ZU5Y@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_176008_14	861299.J421_2553	1.248e-41	160.0	COG1437@1|root,COG1437@2|Bacteria	2|Bacteria	F	CYTH domain	mtaD	-	4.6.1.1	ko:K01768,ko:K05873	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CYTH
SHD1_k127_176008_10	861299.J421_2552	1.652e-77	280.0	COG0546@1|root,COG0546@2|Bacteria,1ZTK9@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD
SHD1_k127_176008_13	861299.J421_2551	1.088e-52	199.0	COG0697@1|root,COG0697@2|Bacteria,1ZTNS@142182|Gemmatimonadetes	142182|Gemmatimonadetes	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
SHD1_k127_176008_15	1379270.AUXF01000004_gene3272	2.21e-41	162.0	2A0X4@1|root,30P27@2|Bacteria,1ZUWS@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_176008_12	861299.J421_2549	1.245e-59	216.0	COG0791@1|root,COG0791@2|Bacteria,1ZTVR@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	NlpC/P60 family	-	-	-	-	-	-	-	-	-	-	-	-	NLPC_P60
SHD1_k127_176008_8	1125863.JAFN01000001_gene2253	1.241e-88	309.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K02481,ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
SHD1_k127_176008_9	861299.J421_2546	1.452e-84	297.0	COG1597@1|root,COG1597@2|Bacteria,1ZU66@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Diacylglycerol kinase catalytic domain (presumed)	-	-	2.7.1.107	ko:K07029	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	-	R02240	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	DAGK_cat
SHD1_k127_176008_0	861299.J421_2545	5.679e-287	935.0	COG2911@1|root,COG2911@2|Bacteria,1ZT97@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	TamB, inner membrane protein subunit of TAM complex	-	-	-	ko:K09800	-	-	-	-	ko00000,ko02000	-	-	-	TamB
SHD1_k127_176008_4	861299.J421_2544	6.167e-124	426.0	COG4775@1|root,COG4775@2|Bacteria,1ZSY7@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	Surface antigen	-	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
SHD1_k127_176008_6	861299.J421_2542	7.394e-112	369.0	COG2199@1|root,COG3706@2|Bacteria	2|Bacteria	T	GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HATPase_c,HisKA,PAS,Response_reg
SHD1_k127_176008_1	861299.J421_2541	1.706e-143	464.0	COG4166@1|root,COG4166@2|Bacteria,1ZSMX@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
SHD1_k127_177115_1	379066.GAU_2903	9.552e-74	251.0	COG2217@1|root,COG2217@2|Bacteria,1ZTC7@142182|Gemmatimonadetes	142182|Gemmatimonadetes	P	E1-E2 ATPase	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
SHD1_k127_177115_3	861299.J421_1942	1.611e-39	157.0	COG1937@1|root,COG1937@2|Bacteria,1ZTZF@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Metal-sensitive transcriptional repressor	-	-	-	ko:K21600	-	-	-	-	ko00000,ko03000	-	-	-	Trns_repr_metal
SHD1_k127_177115_0	1449350.OCH239_17360	4.502e-91	311.0	COG0451@1|root,COG0451@2|Bacteria	2|Bacteria	GM	ADP-glyceromanno-heptose 6-epimerase activity	-	-	1.1.1.219	ko:K00091	-	-	-	-	ko00000,ko01000	-	-	-	Epimerase
SHD1_k127_177115_4	644282.Deba_3082	1.706e-12	79.0	COG0392@1|root,COG0392@2|Bacteria	2|Bacteria	M	lysyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	LPG_synthase_TM
SHD1_k127_177115_2	56110.Oscil6304_5587	1.113e-65	241.0	COG2848@1|root,COG2848@2|Bacteria,1G3IK@1117|Cyanobacteria	1117|Cyanobacteria	S	Uncharacterised ACR (DUF711)	-	-	-	ko:K09157	-	-	-	-	ko00000	-	-	-	DUF711
SHD1_k127_1795426_1	1380355.JNIJ01000022_gene3596	5.855e-79	271.0	COG1116@1|root,COG1116@2|Bacteria,1MUDV@1224|Proteobacteria,2TSH9@28211|Alphaproteobacteria,3JQW2@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	ABC transporter	MA20_34180	-	-	ko:K02049,ko:K15555	ko00920,ko02010,map00920,map02010	M00188,M00436	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.16,3.A.1.17,3.A.1.17.2	-	-	ABC_tran
SHD1_k127_1795426_0	305700.B447_12959	3.754e-79	276.0	COG1014@1|root,COG4231@1|root,COG1014@2|Bacteria,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,2VJGC@28216|Betaproteobacteria,2KY8I@206389|Rhodocyclales	206389|Rhodocyclales	C	COG4231 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits	-	-	1.2.7.8	ko:K04090	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR,TPP_enzyme_C
SHD1_k127_1802030_1	1379270.AUXF01000001_gene2225	1.188e-79	270.0	COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,1ZURP@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	Tricorn protease C1 domain	-	-	-	-	-	-	-	-	-	-	-	-	PD40,PDZ_2,Peptidase_S41,Tricorn_C1
SHD1_k127_1802030_0	861299.J421_4048	1.385e-92	336.0	COG1289@1|root,COG1289@2|Bacteria	2|Bacteria	S	transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FUSC-like,FUSC_2
SHD1_k127_1841487_1	1121378.KB899771_gene643	1.165e-48	180.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
SHD1_k127_1841487_0	1379270.AUXF01000001_gene2129	2.032e-175	561.0	COG1304@1|root,COG1304@2|Bacteria,1ZUNQ@142182|Gemmatimonadetes	2|Bacteria	C	FMN-dependent dehydrogenase	-	-	1.1.3.15,1.1.3.46	ko:K00104,ko:K16422	ko00261,ko00630,ko01055,ko01100,ko01110,ko01120,ko01130,map00261,map00630,map01055,map01100,map01110,map01120,map01130	-	R00475,R06633	RC00042,RC00240	ko00000,ko00001,ko01000	-	-	-	FMN_dh
SHD1_k127_1841487_3	861299.J421_1312	2.9e-31	134.0	COG2318@1|root,COG2318@2|Bacteria,1ZV4R@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
SHD1_k127_1841487_2	1123073.KB899242_gene1301	2.899e-41	160.0	298RU@1|root,3059D@2|Bacteria,1QRA7@1224|Proteobacteria,1TDHB@1236|Gammaproteobacteria,1XAQM@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_1844711_4	1237149.C900_03367	3.757e-62	224.0	COG1277@1|root,COG1277@2|Bacteria,4NGGR@976|Bacteroidetes,47KSX@768503|Cytophagia	976|Bacteroidetes	S	ABC-2 family transporter protein	-	-	-	ko:K19341	ko02010,map02010	M00762	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.132.2	-	-	ABC2_membrane_2,ABC2_membrane_5
SHD1_k127_1844711_3	379066.GAU_1381	1.439e-64	238.0	COG1131@1|root,COG1131@2|Bacteria,1ZV6I@142182|Gemmatimonadetes	142182|Gemmatimonadetes	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990,ko:K19340	ko02010,map02010	M00254,M00762	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.132.2	-	-	ABC_tran
SHD1_k127_1844711_1	379066.GAU_1382	3.02e-113	379.0	COG3420@1|root,COG3420@2|Bacteria	2|Bacteria	P	alginic acid biosynthetic process	nosD	-	-	ko:K07218	-	-	-	-	ko00000	-	-	-	NosD
SHD1_k127_1844711_6	379066.GAU_1384	9.361e-55	206.0	COG4314@1|root,COG4314@2|Bacteria	2|Bacteria	C	lipoprotein involved in nitrous oxide reduction	nosL	-	-	ko:K19342	-	-	-	-	ko00000	-	-	-	NosL
SHD1_k127_1844711_0	945713.IALB_0848	7.959e-292	910.0	COG4263@1|root,COG4263@2|Bacteria	2|Bacteria	C	nitrous-oxide reductase activity	nosZ	GO:0000041,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006812,GO:0006825,GO:0008150,GO:0015677,GO:0030001,GO:0042597,GO:0044464,GO:0051179,GO:0051234	1.7.2.4,1.9.3.1	ko:K00376,ko:K02275	ko00190,ko00910,ko01100,ko01120,map00190,map00910,map01100,map01120	M00155,M00529	R00081,R02804	RC00016,RC02861	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,Cupredoxin_1
SHD1_k127_1844711_5	379066.GAU_2722	2.581e-55	201.0	COG0546@1|root,COG0546@2|Bacteria,1ZU5R@142182|Gemmatimonadetes	142182|Gemmatimonadetes	FJ	Haloacid dehalogenase-like hydrolase	-	-	3.6.1.1	ko:K06019	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	HAD_2
SHD1_k127_1844711_2	861299.J421_4375	8.668e-66	229.0	COG1595@1|root,COG1595@2|Bacteria,1ZTNR@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
SHD1_k127_1844711_7	861299.J421_4376	2.213e-30	132.0	2F756@1|root,33ZKP@2|Bacteria,1ZU38@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_1851680_0	880073.Calab_2813	1.065e-78	282.0	COG1480@1|root,COG1480@2|Bacteria,2NP1K@2323|unclassified Bacteria	2|Bacteria	S	7TM receptor with intracellular HD hydrolase	yqfF	-	-	ko:K07037	-	-	-	-	ko00000	-	-	-	7TM-7TMR_HD,7TMR-HDED,HD
SHD1_k127_1859210_10	515635.Dtur_1030	0.0006973	45.0	COG4726@1|root,COG4726@2|Bacteria	2|Bacteria	NU	Pilus assembly protein PilX	-	-	-	ko:K02673	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilX_N
SHD1_k127_1859210_1	395961.Cyan7425_1270	7.41e-194	618.0	COG1215@1|root,COG2227@1|root,COG1215@2|Bacteria,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	2.4.1.12	ko:K00694,ko:K11936,ko:K20541	ko00500,ko01100,ko02026,map00500,map01100,map02026	-	R02889	RC00005	ko00000,ko00001,ko01000,ko01003,ko02000	4.D.1.1.2,4.D.1.1.3,4.D.3.1.2,4.D.3.1.5,4.D.3.1.6	GT2	-	BcsB,Glycos_transf_2,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_11,Methyltransf_12,PP-binding,ketoacyl-synt
SHD1_k127_1859210_5	402777.KB235903_gene2226	1.174e-75	277.0	2EDZR@1|root,337UJ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_1859210_9	179408.Osc7112_2873	7.134e-18	94.0	COG0457@1|root,COG2227@1|root,COG0457@2|Bacteria,COG2227@2|Bacteria,1GD94@1117|Cyanobacteria,1HEJ7@1150|Oscillatoriales	1117|Cyanobacteria	H	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_2,TPR_8
SHD1_k127_1859210_0	489825.LYNGBM3L_06460	2.124e-256	816.0	COG1216@1|root,COG1216@2|Bacteria,1G2GH@1117|Cyanobacteria,1H9GU@1150|Oscillatoriales	1117|Cyanobacteria	S	Glycosyl transferase family group 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
SHD1_k127_1859210_4	861299.J421_6070	1.24e-88	302.0	COG1682@1|root,COG1682@2|Bacteria	2|Bacteria	GM	macromolecule localization	-	-	-	ko:K01992,ko:K09690	ko02010,map02010	M00250,M00254	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.103	-	-	ABC2_membrane
SHD1_k127_1859210_3	861299.J421_6071	5.357e-104	351.0	COG1134@1|root,COG1134@2|Bacteria	2|Bacteria	GM	teichoic acid transport	-	-	3.6.3.38	ko:K01990,ko:K09689,ko:K09691	ko02010,map02010	M00249,M00250,M00254	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.101,3.A.1.103	-	-	ABC_tran,Wzt_C
SHD1_k127_1859210_6	62928.azo3258	2.993e-67	250.0	COG1216@1|root,COG1216@2|Bacteria,1QVCS@1224|Proteobacteria,2VYMF@28216|Betaproteobacteria	1224|Proteobacteria	S	glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
SHD1_k127_1859210_7	713586.KB900536_gene95	8.106e-58	213.0	COG1216@1|root,COG1216@2|Bacteria	2|Bacteria	V	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
SHD1_k127_1859210_8	207559.Dde_0843	4.199e-29	129.0	COG1215@1|root,COG1215@2|Bacteria,1RIJ7@1224|Proteobacteria,42WPQ@68525|delta/epsilon subdivisions,2WV8H@28221|Deltaproteobacteria,2MCA5@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
SHD1_k127_1859210_2	1267534.KB906757_gene846	2.581e-171	552.0	COG3503@1|root,COG3503@2|Bacteria,3Y3XK@57723|Acidobacteria,2JM1Q@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein of unknown function (DUF1624)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1624
SHD1_k127_1859514_0	234267.Acid_1953	0.0	1181.0	COG4447@1|root,COG4447@2|Bacteria,3Y487@57723|Acidobacteria	57723|Acidobacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_1859514_1	861299.J421_0764	6.962e-207	655.0	COG0612@1|root,COG0612@2|Bacteria,1ZSVK@142182|Gemmatimonadetes	2|Bacteria	S	Insulinase (Peptidase family M16)	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
SHD1_k127_1859514_2	861299.J421_0763	1.64e-159	528.0	COG0612@1|root,COG0612@2|Bacteria	2|Bacteria	L	Peptidase, M16	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
SHD1_k127_1859514_3	861299.J421_0339	1.804e-133	432.0	COG2303@1|root,COG2303@2|Bacteria	2|Bacteria	E	choline dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N
SHD1_k127_1862266_1	1379270.AUXF01000005_gene546	1.586e-20	98.0	COG5529@1|root,COG5529@2|Bacteria,1ZV23@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_1862266_2	68170.KL590490_gene1030	2.355e-17	84.0	2E46R@1|root,32Z2P@2|Bacteria,2GRCW@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_1862266_0	246197.MXAN_5265	2.148e-103	364.0	COG3055@1|root,COG3055@2|Bacteria,1QE0Q@1224|Proteobacteria,4318S@68525|delta/epsilon subdivisions,2WX4P@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Glyoxal oxidase N-terminus	-	-	-	-	-	-	-	-	-	-	-	-	DUF1929,Glyoxal_oxid_N,Kelch_1
SHD1_k127_1863008_3	379066.GAU_1419	3.143e-19	94.0	COG0457@1|root,COG0457@2|Bacteria,1ZSXZ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_1863008_4	1379270.AUXF01000005_gene680	1.004e-15	79.0	2DENK@1|root,2ZNKE@2|Bacteria,1ZV91@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_1863008_1	861299.J421_6252	4.139e-221	699.0	COG1626@1|root,COG1626@2|Bacteria,1ZUQP@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	Trehalase	-	-	3.2.1.28	ko:K01194	ko00500,ko01100,map00500,map01100	-	R00010	RC00049	ko00000,ko00001,ko00537,ko01000	-	GH37	-	Trehalase
SHD1_k127_1863008_0	1379270.AUXF01000002_gene1572	3.402e-260	813.0	COG1263@1|root,COG1264@1|root,COG1263@2|Bacteria,COG1264@2|Bacteria	2|Bacteria	G	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity	ptsG	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008643,GO:0008645,GO:0009401,GO:0015144,GO:0015749,GO:0016020,GO:0016021,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034219,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0090563,GO:0090564,GO:1904659	2.7.1.199	ko:K02778,ko:K02779,ko:K20116,ko:K20117,ko:K20118	ko00010,ko00520,ko02060,ko05111,map00010,map00520,map02060,map05111	M00265,M00809	R02738	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.1.1.1,4.A.1.1.13,4.A.1.1.14,4.A.1.1.9	-	-	PTS_EIIB,PTS_EIIC
SHD1_k127_1863008_2	1267534.KB906755_gene3908	5.088e-89	298.0	COG1080@1|root,COG1080@2|Bacteria	2|Bacteria	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	-	-	2.7.1.202,2.7.3.9	ko:K02768,ko:K08483,ko:K11183,ko:K11189	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273	R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1,8.A.7	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C,PTS-HPr,PTS_EIIA_1
SHD1_k127_1866361_8	861299.J421_3598	1.001e-31	133.0	COG1071@1|root,COG1071@2|Bacteria,1ZT5G@142182|Gemmatimonadetes	2|Bacteria	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	bfmBA	-	1.2.4.1,1.2.4.4	ko:K00161,ko:K11381,ko:K21416	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,Transket_pyr,Transketolase_C
SHD1_k127_1866361_6	379066.GAU_2650	5.479e-66	239.0	COG0515@1|root,COG0515@2|Bacteria,1ZUEB@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K08884	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
SHD1_k127_1866361_1	379066.GAU_0485	9.502e-145	474.0	COG0745@1|root,COG2199@1|root,COG2203@1|root,COG0745@2|Bacteria,COG2203@2|Bacteria,COG3706@2|Bacteria,1ZT7F@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	diguanylate cyclase	-	-	2.7.7.65	ko:K02488	ko02020,ko04112,map02020,map04112	M00511	R08057	-	ko00000,ko00001,ko00002,ko01000,ko02022	-	-	-	GGDEF,Response_reg
SHD1_k127_1866361_3	861299.J421_2397	9.195e-125	408.0	COG1171@1|root,COG1171@2|Bacteria,1ZTBP@142182|Gemmatimonadetes	2|Bacteria	E	Pyridoxal-phosphate dependent enzyme	-	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
SHD1_k127_1866361_5	861299.J421_2396	1.735e-82	278.0	COG0188@1|root,COG0188@2|Bacteria,1ZTFF@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
SHD1_k127_1866361_0	861299.J421_2396	0.0	1030.0	COG0188@1|root,COG0188@2|Bacteria,1ZTFF@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
SHD1_k127_1866361_4	861299.J421_2393	1.894e-88	298.0	COG0668@1|root,COG0668@2|Bacteria,1ZSU5@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	Conserved TM helix	-	-	-	-	-	-	-	-	-	-	-	-	TM_helix
SHD1_k127_1866361_9	379066.GAU_0482	6.395e-28	119.0	28TV6@1|root,2ZG24@2|Bacteria,1ZV98@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_1866361_2	861299.J421_2390	2.268e-141	456.0	COG0604@1|root,COG0604@2|Bacteria,1ZT6R@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
SHD1_k127_1866361_7	379066.GAU_0480	4.313e-35	145.0	COG0508@1|root,COG0508@2|Bacteria,1ZTB5@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2)	-	-	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
SHD1_k127_1866919_2	861299.J421_4236	1.32e-92	317.0	COG2957@1|root,COG2957@2|Bacteria,1ZSZ0@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Porphyromonas-type peptidyl-arginine deiminase	-	-	3.5.3.12	ko:K10536	ko00330,ko01100,map00330,map01100	-	R01416	RC00177	ko00000,ko00001,ko01000	-	-	-	PAD_porph
SHD1_k127_1866919_0	861299.J421_4235	1.246e-136	440.0	COG0388@1|root,COG0388@2|Bacteria,1ZTFB@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Carbon-nitrogen hydrolase	-	-	3.5.1.53	ko:K12251	ko00330,ko01100,map00330,map01100	-	R01152	RC00096	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase
SHD1_k127_1866919_1	861299.J421_4234	1.443e-93	326.0	COG2379@1|root,COG2379@2|Bacteria,1ZTSG@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	MOFRL family	-	-	2.7.1.165	ko:K11529	ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200	M00346	R08572	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4147,MOFRL
SHD1_k127_1866919_3	395964.KE386496_gene2971	1.021e-91	305.0	COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,2TQSN@28211|Alphaproteobacteria,3N9Z9@45404|Beijerinckiaceae	28211|Alphaproteobacteria	E	PFAM aminotransferase class V	-	-	2.6.1.44,2.6.1.45,2.6.1.51	ko:K00830	ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146	M00346,M00532	R00369,R00372,R00585,R00588	RC00006,RC00008,RC00018	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
SHD1_k127_1907452_1	379066.GAU_2650	8.069e-113	386.0	COG0515@1|root,COG0515@2|Bacteria,1ZUEB@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K08884	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
SHD1_k127_1907452_0	760192.Halhy_0960	3.558e-295	936.0	COG4447@1|root,COG4447@2|Bacteria,4P16I@976|Bacteroidetes,1IWTV@117747|Sphingobacteriia	2|Bacteria	G	SPTR Glycosyl hydrolase, BNR repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
SHD1_k127_1909608_11	861299.J421_1313	3.043e-35	143.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	-	-	-	ko:K10914,ko:K21563	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
SHD1_k127_1909608_7	1267534.KB906756_gene234	1.88e-60	211.0	29E7I@1|root,3015I@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1761)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1761
SHD1_k127_1909608_6	1267533.KB906741_gene510	1.973e-66	231.0	COG3832@1|root,COG3832@2|Bacteria,3Y7RQ@57723|Acidobacteria	57723|Acidobacteria	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
SHD1_k127_1909608_4	1267534.KB906756_gene236	3.437e-104	342.0	COG1309@1|root,COG1309@2|Bacteria,3Y4H4@57723|Acidobacteria	57723|Acidobacteria	K	Bacterial transcriptional repressor C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_13,TetR_N
SHD1_k127_1909608_14	504487.JCM19302_1728	0.0002096	53.0	COG3746@1|root,COG3746@2|Bacteria,4NIID@976|Bacteroidetes,1I11K@117743|Flavobacteriia	976|Bacteroidetes	P	Phosphate-selective porin O and P	-	-	-	-	-	-	-	-	-	-	-	-	Porin_4,Porin_O_P
SHD1_k127_1909608_9	1123368.AUIS01000001_gene1849	2.122e-43	164.0	COG4329@1|root,COG4329@2|Bacteria,1RFEI@1224|Proteobacteria,1S71S@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Predicted membrane protein (DUF2243)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2243
SHD1_k127_1909608_13	1122139.KB907888_gene223	4.642e-09	64.0	COG2005@1|root,COG2005@2|Bacteria,1R9YB@1224|Proteobacteria	1224|Proteobacteria	S	PFAM regulatory protein LysR	-	-	-	ko:K02019	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1
SHD1_k127_1909608_5	861299.J421_3781	8.375e-76	266.0	COG0725@1|root,COG0725@2|Bacteria	2|Bacteria	P	tungstate binding	wtpA	-	-	ko:K15495	ko02010,map02010	M00423	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.5	-	-	SBP_bac_11
SHD1_k127_1909608_8	28444.JODQ01000009_gene3783	1.914e-58	207.0	COG4244@1|root,COG4244@2|Bacteria,2HPIP@201174|Actinobacteria,4EQMX@85012|Streptosporangiales	201174|Actinobacteria	S	Predicted membrane protein (DUF2231)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2231
SHD1_k127_1909608_2	670487.Ocepr_1414	3.475e-124	414.0	COG0520@1|root,COG0520@2|Bacteria,1WIPV@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family	-	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
SHD1_k127_1909608_10	1116472.MGMO_8c00560	7.829e-41	157.0	COG0822@1|root,COG0822@2|Bacteria,1RD5K@1224|Proteobacteria,1S3P1@1236|Gammaproteobacteria,1XF3J@135618|Methylococcales	135618|Methylococcales	C	TIGRFAM SUF system FeS	-	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
SHD1_k127_1909608_1	861299.J421_2088	5.278e-165	530.0	COG0719@1|root,COG0719@2|Bacteria,1ZSTG@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	Uncharacterized protein family (UPF0051)	-	-	-	ko:K09015	-	-	-	-	ko00000	-	-	-	UPF0051
SHD1_k127_1909608_3	861299.J421_2089	8.415e-122	394.0	COG0396@1|root,COG0396@2|Bacteria,1ZSRX@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	ABC transporter	sufC	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
SHD1_k127_1909608_0	861299.J421_2090	3.952e-195	611.0	COG0719@1|root,COG0719@2|Bacteria,1ZSMU@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	Uncharacterized protein family (UPF0051)	-	-	-	ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
SHD1_k127_1923917_6	42256.RradSPS_2139	5.51e-31	126.0	COG0667@1|root,COG0667@2|Bacteria,2GJBG@201174|Actinobacteria,4CPGS@84995|Rubrobacteria	84995|Rubrobacteria	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
SHD1_k127_1923917_1	335543.Sfum_3057	2.123e-127	414.0	COG0113@1|root,COG0113@2|Bacteria,1MWMW@1224|Proteobacteria,42N17@68525|delta/epsilon subdivisions,2WJE8@28221|Deltaproteobacteria,2MQY0@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Belongs to the ALAD family	hemB	-	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
SHD1_k127_1923917_2	379066.GAU_2594	5.096e-90	312.0	COG0181@1|root,COG0181@2|Bacteria,1ZTQF@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	-	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	-	Porphobil_deam,Porphobil_deamC
SHD1_k127_1923917_0	266117.Rxyl_1977	1.87e-140	464.0	COG0007@1|root,COG1587@1|root,COG0007@2|Bacteria,COG1587@2|Bacteria,2GMJZ@201174|Actinobacteria,4CU1Q@84995|Rubrobacteria	84995|Rubrobacteria	H	Belongs to the precorrin methyltransferase family	-	-	2.1.1.107,4.2.1.75	ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165,R03194	RC00003,RC00871,RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4,TP_methylase
SHD1_k127_1923917_4	861299.J421_4190	2.451e-87	295.0	COG0755@1|root,COG0755@2|Bacteria,1ZTJG@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	Cytochrome C assembly protein	-	-	-	ko:K02195	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	Cytochrom_C_asm
SHD1_k127_1923917_3	861299.J421_4191	1.198e-88	297.0	COG2386@1|root,COG2386@2|Bacteria,1ZTJ6@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	CcmB protein	-	-	-	ko:K02194	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	CcmB
SHD1_k127_1923917_5	1379270.AUXF01000001_gene2793	1.86e-65	232.0	COG1131@1|root,COG1131@2|Bacteria,1ZTRV@142182|Gemmatimonadetes	142182|Gemmatimonadetes	V	ABC transporter	-	-	3.6.3.41	ko:K02193	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.107	-	-	ABC_tran
SHD1_k127_1941583_0	485916.Dtox_1805	2.385e-15	83.0	COG1595@1|root,COG1595@2|Bacteria,1VANG@1239|Firmicutes,24APW@186801|Clostridia,2630U@186807|Peptococcaceae	186801|Clostridia	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
SHD1_k127_1948388_1	648996.Theam_1474	3.664e-68	240.0	COG0492@1|root,COG0492@2|Bacteria,2G4H4@200783|Aquificae	200783|Aquificae	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
SHD1_k127_1948388_0	1379270.AUXF01000003_gene3870	1.775e-70	244.0	COG0491@1|root,COG0491@2|Bacteria,1ZTMV@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
SHD1_k127_1948388_2	1267533.KB906737_gene1959	2.384e-22	100.0	COG2128@1|root,COG2128@2|Bacteria,3Y8IA@57723|Acidobacteria,2JNES@204432|Acidobacteriia	204432|Acidobacteriia	S	Carboxymuconolactone decarboxylase family	-	-	-	-	-	-	-	-	-	-	-	-	CMD
SHD1_k127_1956592_0	861299.J421_0240	1.642e-242	777.0	COG2091@1|root,COG2091@2|Bacteria,1ZUPU@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Carbohydrate family 9 binding domain-like	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
SHD1_k127_195874_2	326427.Cagg_1243	1.338e-221	701.0	COG0119@1|root,COG0119@2|Bacteria,2G5V9@200795|Chloroflexi,374VT@32061|Chloroflexia	32061|Chloroflexia	H	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
SHD1_k127_195874_4	357808.RoseRS_1966	1.27e-166	533.0	COG0059@1|root,COG0059@2|Bacteria,2G5NP@200795|Chloroflexi,3758Y@32061|Chloroflexia	32061|Chloroflexia	EH	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
SHD1_k127_195874_7	326427.Cagg_1241	4.907e-47	187.0	COG0440@1|root,COG0440@2|Bacteria,2G6NW@200795|Chloroflexi,375KN@32061|Chloroflexia	32061|Chloroflexia	E	PFAM amino acid-binding ACT domain protein	-	-	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT_5,ALS_ss_C
SHD1_k127_195874_1	357808.RoseRS_1968	1.125e-249	795.0	COG0028@1|root,COG0028@2|Bacteria,2G5Q7@200795|Chloroflexi,3751J@32061|Chloroflexia	32061|Chloroflexia	H	TIGRFAM acetolactate synthase, large subunit, biosynthetic type	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
SHD1_k127_195874_0	316274.Haur_4450	3.488e-269	839.0	COG0129@1|root,COG0129@2|Bacteria,2G5QW@200795|Chloroflexi,376BJ@32061|Chloroflexia	32061|Chloroflexia	E	Belongs to the IlvD Edd family	ilvD	GO:0003674,GO:0003824,GO:0004160,GO:0016829,GO:0016835,GO:0016836	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
SHD1_k127_195874_5	357808.RoseRS_1958	5.762e-153	496.0	COG0473@1|root,COG0473@2|Bacteria,2G63C@200795|Chloroflexi,3755M@32061|Chloroflexia	32061|Chloroflexia	C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
SHD1_k127_195874_6	1128421.JAGA01000002_gene1557	2.41e-75	260.0	COG0066@1|root,COG0066@2|Bacteria,2NRA0@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
SHD1_k127_195874_3	357808.RoseRS_1961	8.299e-214	670.0	COG0065@1|root,COG0065@2|Bacteria,2G68G@200795|Chloroflexi,3753P@32061|Chloroflexia	32061|Chloroflexia	H	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	-	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
SHD1_k127_1969992_8	748247.AZKH_3598	3.286e-27	124.0	COG1216@1|root,COG1216@2|Bacteria,1MZSD@1224|Proteobacteria,2VUX2@28216|Betaproteobacteria,2KWYP@206389|Rhodocyclales	206389|Rhodocyclales	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
SHD1_k127_1969992_6	316274.Haur_0248	3.815e-39	150.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	2.3.1.82	ko:K18816	-	-	-	-	br01600,ko00000,ko01000,ko01504	-	-	-	Acetyltransf_1
SHD1_k127_1969992_3	861299.J421_3248	9.008e-53	201.0	COG0438@1|root,COG0438@2|Bacteria,1ZSTJ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
SHD1_k127_1969992_4	861299.J421_3242	1.398e-50	189.0	COG0503@1|root,COG0503@2|Bacteria,1ZTZX@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	apt	-	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
SHD1_k127_1969992_10	252305.OB2597_09494	1.701e-14	77.0	COG1254@1|root,COG1254@2|Bacteria,1PU46@1224|Proteobacteria,2UF7Z@28211|Alphaproteobacteria,2PETD@252301|Oceanicola	28211|Alphaproteobacteria	C	Acylphosphatase	acyP	GO:0003674,GO:0003824,GO:0003998,GO:0016787,GO:0016817,GO:0016818	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	-	R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000	-	-	-	Acylphosphatase
SHD1_k127_1969992_2	861299.J421_3240	4.532e-87	295.0	COG2518@1|root,COG2518@2|Bacteria,1ZTED@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
SHD1_k127_1969992_1	861299.J421_3239	8.025e-113	375.0	COG0496@1|root,COG0496@2|Bacteria,1ZT6W@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates	surE	-	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	SurE
SHD1_k127_1969992_7	342949.PNA2_0182	2.005e-30	130.0	COG0463@1|root,arCOG00894@2157|Archaea,2Y7SV@28890|Euryarchaeota	28890|Euryarchaeota	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
SHD1_k127_1969992_5	379066.GAU_1604	2.534e-48	178.0	COG0789@1|root,COG0789@2|Bacteria,1ZTSI@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	helix_turn_helix, mercury resistance	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
SHD1_k127_1969992_0	379066.GAU_1603	8.661e-123	407.0	COG0240@1|root,COG0240@2|Bacteria,1ZTFK@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus	gpsA	-	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
SHD1_k127_1969992_9	1379270.AUXF01000006_gene285	4.766e-20	93.0	COG0344@1|root,COG0344@2|Bacteria,1ZTTW@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP	plsY	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
SHD1_k127_1970313_5	861299.J421_5670	4.481e-14	75.0	COG0642@1|root,COG2205@2|Bacteria,1ZTAI@142182|Gemmatimonadetes	861299.J421_5670|-	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_1970313_0	278963.ATWD01000001_gene3622	5.917e-88	309.0	COG1231@1|root,COG1231@2|Bacteria,3Y2HW@57723|Acidobacteria,2JIJJ@204432|Acidobacteriia	204432|Acidobacteriia	E	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
SHD1_k127_1970313_6	1128421.JAGA01000002_gene57	1.241e-12	79.0	COG0392@1|root,COG0392@2|Bacteria,2NPGZ@2323|unclassified Bacteria	2|Bacteria	S	Lysylphosphatidylglycerol synthase TM region	mprF	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
SHD1_k127_1970313_3	379066.GAU_2293	7.453e-53	195.0	COG2885@1|root,COG2885@2|Bacteria,1ZTR2@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	OmpA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
SHD1_k127_1970313_1	1379270.AUXF01000003_gene3642	1.366e-70	249.0	COG0164@1|root,COG0164@2|Bacteria,1ZTHY@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	-	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
SHD1_k127_1970313_2	861299.J421_3822	2.6e-59	210.0	COG0335@1|root,COG0335@2|Bacteria,1ZTUC@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site	rplS	-	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
SHD1_k127_1970313_4	1122138.AQUZ01000006_gene1287	2.153e-45	181.0	COG1404@1|root,COG3291@1|root,COG1404@2|Bacteria,COG3291@2|Bacteria,2GJYH@201174|Actinobacteria,4DNZ1@85009|Propionibacteriales	201174|Actinobacteria	O	Peptidase inhibitor I9	-	-	-	-	-	-	-	-	-	-	-	-	Inhibitor_I9,PKD,Peptidase_S8
SHD1_k127_1981072_4	234267.Acid_5930	4.542e-34	138.0	COG1028@1|root,COG1028@2|Bacteria	234267.Acid_5930|-	IQ	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_1981072_2	1217718.ALOU01000049_gene4378	1.389e-86	297.0	COG4977@1|root,COG4977@2|Bacteria,1MUDK@1224|Proteobacteria,2W9CK@28216|Betaproteobacteria,1KC34@119060|Burkholderiaceae	28216|Betaproteobacteria	K	DJ-1/PfpI family	-	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI,HTH_18
SHD1_k127_1981072_0	861299.J421_2337	3.817e-212	673.0	COG0624@1|root,COG0624@2|Bacteria,1ZT2K@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
SHD1_k127_1981072_3	1379270.AUXF01000002_gene1778	4.284e-85	309.0	COG1807@1|root,COG1807@2|Bacteria,1ZUCU@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
SHD1_k127_1981072_1	861299.J421_2334	1.29e-153	494.0	COG1331@1|root,COG1331@2|Bacteria	2|Bacteria	O	Highly conserved protein containing a thioredoxin domain	yyaL	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	GlcNAc_2-epim,Thioredox_DsbH
SHD1_k127_1984266_5	1144325.PMI22_02595	2.247e-07	53.0	COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,1RNV6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	GO:0000096,GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004478,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006556,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009069,GO:0009108,GO:0009116,GO:0009119,GO:0009987,GO:0016740,GO:0016765,GO:0017076,GO:0017144,GO:0019752,GO:0030554,GO:0030955,GO:0031420,GO:0032553,GO:0032555,GO:0032559,GO:0033353,GO:0034641,GO:0035639,GO:0036094,GO:0042278,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0046872,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901576,GO:1901605,GO:1901657	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	iJN746.PP_4967,iYL1228.KPN_03375	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
SHD1_k127_1984266_0	909663.KI867150_gene944	6.171e-182	578.0	COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,42M83@68525|delta/epsilon subdivisions,2WIZE@28221|Deltaproteobacteria,2MQA7@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
SHD1_k127_1984266_3	861299.J421_3129	1.898e-60	214.0	COG1259@1|root,COG1259@2|Bacteria,1ZTKW@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Bifunctional nuclease	-	-	-	ko:K08999	-	-	-	-	ko00000	-	-	-	DNase-RNase
SHD1_k127_1984266_2	861299.J421_3130	1.619e-75	270.0	COG2010@1|root,COG2010@2|Bacteria,1ZT9T@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_1984266_1	861299.J421_3131	2.73e-84	289.0	COG0614@1|root,COG0614@2|Bacteria,1ZTIM@142182|Gemmatimonadetes	142182|Gemmatimonadetes	P	Periplasmic binding protein	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
SHD1_k127_1984266_4	414684.RC1_3872	1.27e-09	64.0	COG0609@1|root,COG0609@2|Bacteria,1MV9W@1224|Proteobacteria,2TR9A@28211|Alphaproteobacteria,2JQCQ@204441|Rhodospirillales	204441|Rhodospirillales	U	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily	-	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
SHD1_k127_1987994_0	1267533.KB906737_gene1492	9.874e-65	242.0	COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,3Y6GN@57723|Acidobacteria,2JMDS@204432|Acidobacteriia	204432|Acidobacteriia	P	transport	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
SHD1_k127_199925_6	304371.MCP_0377	5.488e-17	84.0	COG0705@1|root,COG3582@1|root,arCOG01768@2157|Archaea,arCOG01769@2157|Archaea,2XTJH@28890|Euryarchaeota,2N9X9@224756|Methanomicrobia	224756|Methanomicrobia	E	Rhomboid family	-	-	-	ko:K07059	-	-	-	-	ko00000	-	-	-	Rhomboid,zf-AN1
SHD1_k127_199925_0	861299.J421_1003	1.218e-110	377.0	COG3307@1|root,COG3307@2|Bacteria	2|Bacteria	M	-O-antigen	-	-	-	-	-	-	-	-	-	-	-	-	Wzy_C
SHD1_k127_199925_2	1123073.KB899242_gene1457	8.931e-49	183.0	COG0500@1|root,COG0500@2|Bacteria,1R947@1224|Proteobacteria,1SUF1@1236|Gammaproteobacteria,1X4RG@135614|Xanthomonadales	135614|Xanthomonadales	Q	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_12,Methyltransf_23,Methyltransf_25
SHD1_k127_199925_7	861299.J421_2599	2.125e-11	72.0	2F4AY@1|root,2ZG3Q@2|Bacteria,1ZU5Q@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_199925_9	457396.CSBG_02782	5.483e-07	56.0	28Z2D@1|root,2ZKUW@2|Bacteria,1W52V@1239|Firmicutes,24SJF@186801|Clostridia,36PI2@31979|Clostridiaceae	186801|Clostridia	S	Domain of Unknown Function (DUF350)	-	-	-	-	-	-	-	-	-	-	-	-	DUF350
SHD1_k127_199925_3	2340.JV46_22660	5.622e-36	149.0	COG4623@1|root,COG4623@2|Bacteria,1QUQJ@1224|Proteobacteria,1T218@1236|Gammaproteobacteria,1JBK3@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Transglycosylase SLT domain	-	-	-	-	-	-	-	-	-	-	-	-	SLT
SHD1_k127_199925_5	1250232.JQNJ01000001_gene2672	1.589e-18	94.0	COG1416@1|root,COG1416@2|Bacteria,4NH85@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_199925_1	1249627.D779_3016	3.449e-77	261.0	COG0225@1|root,COG0225@2|Bacteria,1MVUS@1224|Proteobacteria,1RNWU@1236|Gammaproteobacteria,1WY4G@135613|Chromatiales	135613|Chromatiales	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
SHD1_k127_199925_4	861299.J421_1258	2.003e-35	143.0	COG3652@1|root,COG3652@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4142)	-	-	-	ko:K08995	-	-	-	-	ko00000	-	-	-	DUF4142
SHD1_k127_2001031_3	509635.N824_00905	1.603e-77	275.0	COG3673@1|root,COG3673@2|Bacteria,4NHDR@976|Bacteroidetes,1IQ8B@117747|Sphingobacteriia	976|Bacteroidetes	S	Uncharacterized alpha/beta hydrolase domain (DUF2235)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2235
SHD1_k127_2001031_7	580332.Slit_0298	1.035e-24	104.0	COG0053@1|root,COG0053@2|Bacteria,1N8A3@1224|Proteobacteria,2VX4U@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2001031_6	861299.J421_2255	9.977e-43	158.0	COG0640@1|root,COG0640@2|Bacteria,1ZV07@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
SHD1_k127_2001031_1	379066.GAU_0703	6.412e-133	429.0	COG0500@1|root,COG2226@2|Bacteria,1ZSM8@142182|Gemmatimonadetes	142182|Gemmatimonadetes	Q	Hypothetical methyltransferase	-	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_31
SHD1_k127_2001031_5	861299.J421_2257	7.455e-43	162.0	COG1246@1|root,COG1246@2|Bacteria,1ZV2J@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Acetyltransferase (GNAT) domain	-	-	2.3.1.1	ko:K00619	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_1
SHD1_k127_2001031_2	1379270.AUXF01000001_gene2711	7.674e-109	361.0	COG0639@1|root,COG0639@2|Bacteria,1ZUFY@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos_2
SHD1_k127_2001031_4	251221.35210563	2.455e-60	228.0	COG0580@1|root,COG0580@2|Bacteria,1G0AW@1117|Cyanobacteria	1117|Cyanobacteria	U	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity	-	-	-	ko:K06188	-	-	-	-	ko00000,ko02000	1.A.8	-	-	MIP
SHD1_k127_2001031_0	379066.GAU_2424	3.103e-212	668.0	COG4108@1|root,COG4108@2|Bacteria,1ZSMR@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP	prfC	-	-	ko:K02837	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,RF3_C
SHD1_k127_2007259_14	861299.J421_2588	8.834e-07	50.0	COG0520@1|root,COG0520@2|Bacteria,1ZTDV@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
SHD1_k127_2007259_12	84531.JMTZ01000141_gene1680	3.788e-16	89.0	COG2267@1|root,COG2267@2|Bacteria,1N0W6@1224|Proteobacteria,1S931@1236|Gammaproteobacteria,1XB0F@135614|Xanthomonadales	135614|Xanthomonadales	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
SHD1_k127_2007259_3	861299.J421_2590	2.647e-172	551.0	COG0162@1|root,COG0162@2|Bacteria,1ZT43@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
SHD1_k127_2007259_0	379066.GAU_0644	1.588e-296	928.0	COG5009@1|root,COG5009@2|Bacteria,1ZT3R@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	Transglycosylase	-	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
SHD1_k127_2007259_10	861299.J421_2592	2.187e-90	304.0	COG1387@1|root,COG1387@2|Bacteria	2|Bacteria	E	zinc ion binding	-	-	3.1.3.97	ko:K04477,ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	PHP
SHD1_k127_2007259_6	861299.J421_2593	1.314e-118	399.0	COG0402@1|root,COG0402@2|Bacteria,1ZSMH@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Amidohydrolase family	-	-	3.5.4.28,3.5.4.31,3.5.4.40	ko:K12960,ko:K20810	ko00130,ko00270,ko01100,ko01110,map00130,map00270,map01100,map01110	-	R09660,R10695	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
SHD1_k127_2007259_5	339860.Msp_0015	3.316e-122	400.0	COG0115@1|root,arCOG02297@2157|Archaea,2XT9V@28890|Euryarchaeota,23NNK@183925|Methanobacteria	183925|Methanobacteria	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
SHD1_k127_2007259_8	861299.J421_2594	5.234e-100	329.0	COG1403@1|root,COG1403@2|Bacteria,1ZTF1@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	HNH nucleases	-	-	-	-	-	-	-	-	-	-	-	-	HNH_5
SHD1_k127_2007259_11	861299.J421_2595	1.723e-50	186.0	2F73W@1|root,33ZJG@2|Bacteria,1ZTT7@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2007259_7	861299.J421_2596	1.654e-110	384.0	2EW4E@1|root,33PHK@2|Bacteria,1ZT53@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2007259_2	1379270.AUXF01000004_gene3232	3.004e-195	617.0	COG2204@1|root,COG2204@2|Bacteria,1ZSW0@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	Sigma-54 interaction domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
SHD1_k127_2007259_9	379066.GAU_0652	1.033e-94	325.0	COG5000@1|root,COG5000@2|Bacteria,1ZTBX@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
SHD1_k127_2007259_1	861299.J421_2604	1.059e-246	771.0	COG0318@1|root,COG0318@2|Bacteria,1ZSXP@142182|Gemmatimonadetes	142182|Gemmatimonadetes	IQ	AMP-binding enzyme C-terminal domain	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
SHD1_k127_2007259_4	379066.GAU_0654	1.088e-128	418.0	COG1432@1|root,COG1432@2|Bacteria,1ZSRW@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	OST-HTH/LOTUS domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN,OST-HTH
SHD1_k127_2025239_1	861299.J421_2948	3.493e-63	224.0	COG0823@1|root,COG4775@1|root,COG0823@2|Bacteria,COG4775@2|Bacteria,1ZSUS@142182|Gemmatimonadetes	142182|Gemmatimonadetes	MU	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	Bac_surface_Ag,PD40
SHD1_k127_2025239_0	861299.J421_2947	4.03e-114	386.0	COG3087@1|root,COG3087@2|Bacteria,1ZSYS@142182|Gemmatimonadetes	142182|Gemmatimonadetes	D	Sporulation related domain	-	-	-	-	-	-	-	-	-	-	-	-	SPOR
SHD1_k127_2025239_2	861299.J421_2946	5.79e-34	145.0	COG3087@1|root,COG3087@2|Bacteria,1ZTII@142182|Gemmatimonadetes	142182|Gemmatimonadetes	D	Sporulation related domain	-	-	-	-	-	-	-	-	-	-	-	-	SPOR
SHD1_k127_2033440_4	861299.J421_2365	6.656e-09	65.0	2C181@1|root,34B2S@2|Bacteria,1ZU30@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2033440_2	861299.J421_2366	5.696e-34	143.0	2BWJK@1|root,3480I@2|Bacteria,1ZU2S@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2033440_5	1122925.KB895387_gene2807	1.563e-06	54.0	2DREZ@1|root,33BFB@2|Bacteria,1UPXP@1239|Firmicutes,4IVCS@91061|Bacilli,2743X@186822|Paenibacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2033440_3	861299.J421_3012	4.683e-26	110.0	COG2919@1|root,COG2919@2|Bacteria,1ZU6R@142182|Gemmatimonadetes	142182|Gemmatimonadetes	D	Septum formation initiator	-	-	-	ko:K05589	-	-	-	-	ko00000,ko03036	-	-	-	DivIC
SHD1_k127_2033440_0	1219626.HMPREF1639_01725	9.054e-178	565.0	COG0148@1|root,COG0148@2|Bacteria,1TP2S@1239|Firmicutes,247TU@186801|Clostridia,25QP6@186804|Peptostreptococcaceae	186801|Clostridia	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
SHD1_k127_2033440_1	861299.J421_3010	3.01e-53	192.0	COG0204@1|root,COG0204@2|Bacteria,1ZT6D@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Phosphate acyltransferases	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
SHD1_k127_2052747_0	861299.J421_2908	7.372e-194	617.0	COG0515@1|root,COG0515@2|Bacteria,1ZTB4@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
SHD1_k127_2052747_2	1416760.AYMS01000002_gene1856	1.531e-24	109.0	COG0756@1|root,COG0756@2|Bacteria,4NNI4@976|Bacteroidetes,1I1AC@117743|Flavobacteriia,47I5C@76831|Myroides	976|Bacteroidetes	F	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA	dut	GO:0000287,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576	3.6.1.23	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00053	R02100,R11896	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	dUTPase
SHD1_k127_2052747_1	861299.J421_3952	1.832e-82	291.0	COG2909@1|root,COG3629@1|root,COG2909@2|Bacteria,COG3629@2|Bacteria,1ZSY4@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16
SHD1_k127_2058113_1	861299.J421_4181	7.646e-123	419.0	COG0644@1|root,COG0644@2|Bacteria,1ZTEM@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Glucose inhibited division protein A	-	-	1.3.99.38	ko:K21401	-	-	-	-	ko00000,ko01000	-	-	-	FAD_binding_3
SHD1_k127_2058113_3	443144.GM21_3236	9.973e-95	328.0	COG1032@1|root,COG1032@2|Bacteria,1MUMS@1224|Proteobacteria,42QFG@68525|delta/epsilon subdivisions,2WK91@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
SHD1_k127_2058113_5	861299.J421_4180	1.875e-60	219.0	COG1836@1|root,COG1836@2|Bacteria,1ZTT3@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Integral membrane protein DUF92	-	-	-	-	-	-	-	-	-	-	-	-	DUF92
SHD1_k127_2058113_7	469371.Tbis_2922	5.49e-10	65.0	COG5662@1|root,COG5662@2|Bacteria,2IM2X@201174|Actinobacteria,4E6KJ@85010|Pseudonocardiales	201174|Actinobacteria	K	anti-sigma factor	rsrA	GO:0000988,GO:0000989,GO:0003674,GO:0005488,GO:0006950,GO:0006979,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009593,GO:0009628,GO:0009889,GO:0010556,GO:0016989,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0032502,GO:0042221,GO:0043167,GO:0043169,GO:0043934,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051606,GO:0051775,GO:0051776,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2001141	-	-	-	-	-	-	-	-	-	-	zf-HC2
SHD1_k127_2058113_4	861299.J421_4179	1.586e-63	224.0	2C9AX@1|root,33WUH@2|Bacteria,1ZTQK@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2058113_0	861299.J421_4178	2.927e-162	526.0	COG0006@1|root,COG0006@2|Bacteria,1ZSPF@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Metallopeptidase family M24	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M24
SHD1_k127_2058113_6	715451.ambt_06205	1.793e-14	85.0	2EIYW@1|root,33CQ3@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2058113_2	861299.J421_4174	1.196e-101	336.0	COG1132@1|root,COG1132@2|Bacteria,1ZSP1@142182|Gemmatimonadetes	142182|Gemmatimonadetes	V	ABC transporter transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	ABC_membrane,ABC_tran
SHD1_k127_2062479_3	861299.J421_0905	3.612e-99	336.0	COG1466@1|root,COG1466@2|Bacteria,1ZSSZ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	DNA polymerase III, delta subunit	-	-	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta
SHD1_k127_2062479_8	379066.GAU_3914	1.963e-15	87.0	2FFVA@1|root,347SB@2|Bacteria,1ZTX8@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2062479_2	861299.J421_0907	7.025e-104	345.0	COG1595@1|root,COG1595@2|Bacteria,1ZT2V@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	ECF sigma factor	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
SHD1_k127_2062479_5	379066.GAU_3916	2.654e-70	242.0	COG0494@1|root,COG0494@2|Bacteria,1ZTQ5@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	NUDIX domain	-	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
SHD1_k127_2062479_1	861299.J421_0915	1.153e-161	523.0	COG0612@1|root,COG0612@2|Bacteria,1ZT9J@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Insulinase (Peptidase family M16)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
SHD1_k127_2062479_0	861299.J421_0916	5.259e-205	646.0	COG0612@1|root,COG0612@2|Bacteria,1ZSVK@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Insulinase (Peptidase family M16)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
SHD1_k127_2062479_6	1380390.JIAT01000010_gene4322	9.766e-69	237.0	COG1795@1|root,COG1795@2|Bacteria	2|Bacteria	S	PFAM Formaldehyde-activating enzyme (Fae)	fae	-	4.2.1.147	ko:K10713	ko00680,ko01120,ko01200,map00680,map01120,map01200	-	R08058	RC01583,RC01795	ko00000,ko00001,ko01000	-	-	-	Fae
SHD1_k127_2062479_4	1304874.JAFY01000002_gene379	3.035e-77	269.0	COG1063@1|root,COG1063@2|Bacteria,3TC4R@508458|Synergistetes	508458|Synergistetes	E	Methylene-tetrahydromethanopterin dehydrogenase, N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Mpt_N
SHD1_k127_2062479_7	1210884.HG799472_gene14835	9.153e-28	118.0	COG2441@1|root,COG2441@2|Bacteria,2IYYM@203682|Planctomycetes	203682|Planctomycetes	C	Protein of unknown function (DUF1464)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1464
SHD1_k127_2070495_4	861299.J421_2808	2.538e-133	434.0	COG0492@1|root,COG0492@2|Bacteria,1ZSW9@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_3
SHD1_k127_2070495_0	861299.J421_2810	3.711e-229	716.0	COG0423@1|root,COG0423@2|Bacteria,1ZT4P@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Catalyzes the attachment of glycine to tRNA(Gly)	glyQS	-	6.1.1.14	ko:K01880	ko00970,map00970	M00359,M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	HGTP_anticodon,tRNA-synt_2b
SHD1_k127_2070495_1	861299.J421_2812	3.865e-174	559.0	COG1164@1|root,COG1164@2|Bacteria	2|Bacteria	E	metalloendopeptidase activity	-	-	-	ko:K08602	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	-
SHD1_k127_2070495_6	861299.J421_2815	6.595e-75	259.0	COG4221@1|root,COG4221@2|Bacteria,1ZTIV@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
SHD1_k127_2070495_10	42256.RradSPS_2414	5.045e-08	64.0	29ITM@1|root,305QZ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2070495_3	861299.J421_2816	2.94e-151	491.0	COG5002@1|root,COG5002@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	-	-	2.7.13.3	ko:K03407,ko:K07678	ko02020,ko02025,ko02026,ko02030,ko05111,map02020,map02025,map02026,map02030,map05111	M00475,M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	GAF_2,HAMP,HATPase_c,HisKA,Hpt,PAS,PAS_4,PAS_7,PAS_9,Response_reg
SHD1_k127_2070495_7	861299.J421_2817	3.695e-29	119.0	2FC5K@1|root,3449E@2|Bacteria,1ZU4V@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2070495_9	861299.J421_2818	2.49e-12	72.0	2C3VP@1|root,2ZRAS@2|Bacteria,1ZU7P@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2070495_2	861299.J421_0520	2.086e-152	489.0	COG0714@1|root,COG0714@2|Bacteria,1ZT4A@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
SHD1_k127_2070495_5	861299.J421_0522	3.311e-76	265.0	COG1721@1|root,COG1721@2|Bacteria,1ZTP6@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
SHD1_k127_2070495_8	861299.J421_0523	1.068e-15	83.0	2FFKA@1|root,347HR@2|Bacteria,1ZU3F@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2072064_2	1187851.A33M_0007	2.883e-28	131.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2TR49@28211|Alphaproteobacteria,3FDWR@34008|Rhodovulum	28211|Alphaproteobacteria	E	Gamma-glutamyltranspeptidase	ggt	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
SHD1_k127_2072064_1	861299.J421_2018	2.486e-38	151.0	COG0586@1|root,COG0586@2|Bacteria,1ZTZ1@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
SHD1_k127_2072064_0	861299.J421_3689	4.216e-42	159.0	COG3127@1|root,COG3127@2|Bacteria,1ZT3A@142182|Gemmatimonadetes	142182|Gemmatimonadetes	Q	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
SHD1_k127_20829_3	1379270.AUXF01000006_gene46	3.406e-66	233.0	COG4464@1|root,COG4464@2|Bacteria,1ZTQH@142182|Gemmatimonadetes	142182|Gemmatimonadetes	GM	protein tyrosine phosphatase activity	-	-	3.1.3.48	ko:K01104	-	-	-	-	ko00000,ko01000	-	-	-	-
SHD1_k127_20829_2	861299.J421_3519	2.223e-73	254.0	COG0279@1|root,COG0279@2|Bacteria,1ZTY5@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	SIS domain	-	-	5.3.1.28	ko:K03271	ko00540,ko01100,map00540,map01100	M00064	R05645,R09768,R09769	RC00434	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	SIS_2
SHD1_k127_20829_1	861299.J421_3518	1.607e-94	316.0	COG1028@1|root,COG1028@2|Bacteria,1ZTJK@142182|Gemmatimonadetes	142182|Gemmatimonadetes	IQ	KR domain	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
SHD1_k127_20829_0	861299.J421_3513	4.522e-116	383.0	COG0617@1|root,COG0617@2|Bacteria,1ZSKW@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Probable RNA and SrmB- binding site of polymerase A	-	-	2.7.7.72	ko:K00974	ko03013,map03013	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	PolyA_pol,PolyA_pol_RNAbd,tRNA_NucTran2_2
SHD1_k127_2085271_0	1379270.AUXF01000003_gene3614	1.953e-67	250.0	COG1629@1|root,COG4771@2|Bacteria,1ZUBX@142182|Gemmatimonadetes	142182|Gemmatimonadetes	P	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,Plug,TonB_dep_Rec
SHD1_k127_2085271_1	861299.J421_2634	6.321e-46	185.0	28P8D@1|root,2ZC2C@2|Bacteria,1ZUEX@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2085271_3	861299.J421_1340	1.006e-22	108.0	COG0312@1|root,COG0312@2|Bacteria,1ZSUE@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Putative modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD,TAT_signal
SHD1_k127_2085271_2	379066.GAU_0018	1.693e-38	150.0	COG0312@1|root,COG0312@2|Bacteria,1ZSWE@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Putative modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
SHD1_k127_2086929_11	861299.J421_1328	3.89e-07	53.0	COG0002@1|root,COG0002@2|Bacteria,1ZSV7@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	-	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
SHD1_k127_2086929_5	861299.J421_1325	6.897e-46	173.0	COG1438@1|root,COG1438@2|Bacteria,1ZU02@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Regulates arginine biosynthesis genes	argR	-	-	ko:K03402	-	-	-	-	ko00000,ko03000	-	-	-	Arg_repressor,Arg_repressor_C
SHD1_k127_2086929_4	861299.J421_1323	3.425e-52	186.0	COG0137@1|root,COG0137@2|Bacteria,1ZTYP@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Arginosuccinate synthase	argG	-	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
SHD1_k127_2086929_1	861299.J421_1323	4.133e-145	464.0	COG0137@1|root,COG0137@2|Bacteria,1ZTYP@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Arginosuccinate synthase	argG	-	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
SHD1_k127_2086929_2	383372.Rcas_3075	2.62e-142	466.0	COG0165@1|root,COG0165@2|Bacteria,2G616@200795|Chloroflexi,375AG@32061|Chloroflexia	32061|Chloroflexia	E	PFAM fumarate lyase	argH	GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
SHD1_k127_2086929_8	861299.J421_1300	7.81e-35	135.0	COG1278@1|root,COG1278@2|Bacteria,1ZTZ4@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Cold shock protein domain	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
SHD1_k127_2086929_7	395494.Galf_2904	8.578e-40	154.0	2DM6D@1|root,31WQ8@2|Bacteria,1MZ7P@1224|Proteobacteria,2VUHB@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2086929_0	861299.J421_1297	1.006e-205	647.0	COG0821@1|root,COG0821@2|Bacteria,1ZST3@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	-	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
SHD1_k127_2086929_3	379066.GAU_0145	9.365e-72	247.0	COG0317@1|root,COG0317@2|Bacteria,1ZTKE@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KT	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	HD_4
SHD1_k127_2086929_9	1379270.AUXF01000002_gene1412	5.277e-23	104.0	2EGQF@1|root,33AGK@2|Bacteria,1ZU11@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2086929_10	287986.DV20_29650	3.913e-18	95.0	COG0823@1|root,COG2304@1|root,COG0823@2|Bacteria,COG2304@2|Bacteria,2GMNT@201174|Actinobacteria,4DXHJ@85010|Pseudonocardiales	201174|Actinobacteria	U	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	HYR,PD40,VWA
SHD1_k127_2086929_12	111780.Sta7437_0773	6.028e-07	59.0	2DRDY@1|root,33BC0@2|Bacteria,1G9R7@1117|Cyanobacteria,3VKRJ@52604|Pleurocapsales	1117|Cyanobacteria	S	Coenzyme PQQ synthesis protein D (PqqD)	-	-	-	-	-	-	-	-	-	-	-	-	PqqD
SHD1_k127_2086929_13	517722.AEUE01000009_gene696	2.307e-05	55.0	COG5019@1|root,COG5019@2|Bacteria,1QZBU@1224|Proteobacteria,2TYT0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	DZ	ATPase. Has a role at an early stage in the morphogenesis of the spore coat	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2086929_6	861299.J421_1278	2.237e-43	173.0	COG0489@1|root,COG0489@2|Bacteria	2|Bacteria	D	protein tyrosine kinase activity	-	-	-	ko:K16692	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	AAA_31,CBP_BcsQ
SHD1_k127_2087570_1	234267.Acid_1531	2.28e-188	601.0	COG0728@1|root,COG0728@2|Bacteria,3Y6N1@57723|Acidobacteria	57723|Acidobacteria	S	MviN-like protein	-	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
SHD1_k127_2087570_0	861299.J421_3231	2.249e-278	879.0	COG0322@1|root,COG0322@2|Bacteria,1ZSXE@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_5,UVR,UvrC_HhH_N
SHD1_k127_2087570_2	861299.J421_3233	1.457e-143	466.0	COG1641@1|root,COG1641@2|Bacteria	2|Bacteria	H	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes	larC	-	4.99.1.12	ko:K06898,ko:K09121	-	-	-	-	ko00000,ko01000	-	-	-	DUF111
SHD1_k127_2097130_0	379066.GAU_2620	0.0	1217.0	COG1048@1|root,COG1048@2|Bacteria,1ZTE7@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	-	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
SHD1_k127_2097130_2	861299.J421_4226	8.849e-115	379.0	COG0624@1|root,COG0624@2|Bacteria,1ZSV0@142182|Gemmatimonadetes	2|Bacteria	E	Peptidase dimerisation domain	-	-	3.5.1.16	ko:K01438	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R00669,R09107	RC00064,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
SHD1_k127_2097130_1	861299.J421_4225	3.149e-119	392.0	COG1141@1|root,COG1752@1|root,COG1141@2|Bacteria,COG1752@2|Bacteria,1ZT7Z@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	4Fe-4S single cluster domain	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Fer4_15,Patatin
SHD1_k127_2101286_2	1379270.AUXF01000006_gene160	4.537e-111	366.0	COG0265@1|root,COG0265@2|Bacteria,1ZTAM@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	Trypsin	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
SHD1_k127_2101286_0	861299.J421_3373	3.615e-194	624.0	COG0015@1|root,COG0015@2|Bacteria,1ZSVW@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Adenylosuccinate lyase C-terminus	-	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
SHD1_k127_2101286_1	316058.RPB_0702	4.587e-137	442.0	COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,2TS0T@28211|Alphaproteobacteria,3JRJ7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	F	phosphoribosylaminoimidazole-succinocarboxamide synthase	purC2	GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
SHD1_k127_2101286_3	861299.J421_3375	9.094e-76	263.0	COG0688@1|root,COG0688@2|Bacteria,1ZU9Z@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer)	psd	-	4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PS_Dcarbxylase
SHD1_k127_2101286_4	379066.GAU_1734	1.84e-19	100.0	COG1183@1|root,COG1183@2|Bacteria,1ZTJP@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	CDP-alcohol phosphatidyltransferase	-	-	2.7.8.8	ko:K17103	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	M00093	R01800	RC00002,RC00017,RC02795	ko00000,ko00001,ko00002,ko01000	-	-	-	CDP-OH_P_transf
SHD1_k127_2107797_0	861299.J421_3349	8.246e-261	809.0	COG1884@1|root,COG1884@2|Bacteria,1ZUKS@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Methylmalonyl-CoA mutase	-	-	5.4.99.13,5.4.99.2	ko:K01848,ko:K11942	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
SHD1_k127_2107797_1	1379270.AUXF01000006_gene179	5.494e-130	426.0	COG1703@1|root,COG1703@2|Bacteria,1ZT8J@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	ArgK protein	-	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK
SHD1_k127_2107797_3	861299.J421_3351	6.125e-72	258.0	COG1253@1|root,COG1253@2|Bacteria,1ZTJW@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Domain of unknown function DUF21	-	-	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,DUF21
SHD1_k127_2107797_2	861299.J421_3352	1.163e-119	400.0	COG1253@1|root,COG1253@2|Bacteria,1ZT3E@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Transporter associated domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC
SHD1_k127_2107797_5	861299.J421_3353	4.15e-40	154.0	COG0319@1|root,COG0319@2|Bacteria,1ZTUP@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA	ybeY	-	-	ko:K07042	-	-	-	-	ko00000,ko03009	-	-	-	UPF0054
SHD1_k127_2107797_4	861299.J421_3354	5.316e-54	193.0	COG1480@1|root,COG1480@2|Bacteria	2|Bacteria	O	7TM receptor with intracellular HD hydrolase	yqfF	-	-	ko:K07037	-	-	-	-	ko00000	-	-	-	7TM-7TMR_HD,7TMR-HDED,HD
SHD1_k127_2113481_0	861299.J421_1845	5.615e-160	515.0	COG1858@1|root,COG1858@2|Bacteria,1ZV0F@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Di-haem cytochrome c peroxidase	-	-	1.11.1.5	ko:K00428	-	-	-	-	ko00000,ko01000	-	-	-	CCP_MauG,Cytochrom_C
SHD1_k127_2113481_7	861299.J421_1846	2.668e-53	192.0	2E4GK@1|root,32ZBS@2|Bacteria	2|Bacteria	S	YtkA-like	-	-	-	-	-	-	-	-	-	-	-	-	YtkA
SHD1_k127_2113481_2	861299.J421_1848	1.314e-100	337.0	COG2207@1|root,COG2207@2|Bacteria,1ZV3U@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	helix_turn_helix, arabinose operon control protein	-	-	-	ko:K07506	-	-	-	-	ko00000,ko03000	-	-	-	AraC_binding,HTH_18
SHD1_k127_2113481_6	861299.J421_5926	2.924e-76	265.0	COG1670@1|root,COG1670@2|Bacteria	2|Bacteria	J	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_3,GNAT_acetyltran
SHD1_k127_2113481_4	861299.J421_5928	4.307e-82	282.0	COG2207@1|root,COG2207@2|Bacteria	2|Bacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
SHD1_k127_2113481_3	290399.Arth_0438	1.809e-86	292.0	2C1EG@1|root,2Z7MZ@2|Bacteria,2GK4W@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2113481_8	1312959.KI914644_gene1088	5.189e-18	87.0	2C1EG@1|root,2Z7MZ@2|Bacteria,2GK4W@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2113481_10	1415166.NONO_c22500	5.756e-06	55.0	COG3103@1|root,COG3103@2|Bacteria,2GU0X@201174|Actinobacteria,4G3T1@85025|Nocardiaceae	201174|Actinobacteria	T	Protein of unknown function (DUF3761)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3761
SHD1_k127_2113481_5	661478.OP10G_3433	1.424e-81	290.0	COG0666@1|root,COG0666@2|Bacteria	2|Bacteria	G	response to abiotic stimulus	-	-	-	ko:K06867	-	-	-	-	ko00000	-	-	-	Ank,Ank_2,Ank_4,Ank_5
SHD1_k127_2113481_1	1267533.KB906737_gene1537	8.944e-111	384.0	COG3055@1|root,COG3485@1|root,COG3055@2|Bacteria,COG3485@2|Bacteria,3Y8A3@57723|Acidobacteria	57723|Acidobacteria	Q	protocatechuate 3,4-dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2113481_9	911045.PSE_1281	8.931e-08	60.0	2CXSR@1|root,32T2I@2|Bacteria,1MZUX@1224|Proteobacteria,2U6EW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4383
SHD1_k127_2117509_1	861299.J421_3564	5.59e-104	345.0	COG2003@1|root,COG2003@2|Bacteria,1ZTFU@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	RadC-like JAB domain	-	-	-	ko:K03630	-	-	-	-	ko00000	-	-	-	RadC
SHD1_k127_2117509_0	861299.J421_3566	0.0	1568.0	COG0653@1|root,COG0653@2|Bacteria,1ZSMK@142182|Gemmatimonadetes	142182|Gemmatimonadetes	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
SHD1_k127_2117509_2	861299.J421_3567	3.139e-53	195.0	COG1057@1|root,COG1057@2|Bacteria,1ZTT1@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	-	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
SHD1_k127_2118406_2	861299.J421_3974	9.518e-164	521.0	COG0082@1|root,COG0082@2|Bacteria,1ZT39@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	-	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
SHD1_k127_2118406_3	1379270.AUXF01000003_gene3401	3.229e-50	186.0	COG0703@1|root,COG0703@2|Bacteria,1ZTXW@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	aroK	-	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	SKI
SHD1_k127_2118406_4	1379270.AUXF01000003_gene3402	2.884e-20	92.0	2FGYD@1|root,348TM@2|Bacteria,1ZU4H@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Protein of unknown function (DUF494)	-	-	-	ko:K03747	-	-	-	-	ko00000	-	-	-	DUF494
SHD1_k127_2118406_0	861299.J421_3971	0.0	1095.0	COG0550@1|root,COG0550@2|Bacteria,1ZTA9@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,zf-C4_Topoisom
SHD1_k127_2118406_1	1379270.AUXF01000003_gene3404	4.897e-200	632.0	COG1206@1|root,COG1206@2|Bacteria,1ZTB8@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs	gid	-	2.1.1.74	ko:K04094	-	-	-	-	ko00000,ko01000,ko03016,ko03036	-	-	-	GIDA
SHD1_k127_2118406_5	861299.J421_3967	6.397e-16	91.0	COG4974@1|root,COG4974@2|Bacteria,1ZT3T@142182|Gemmatimonadetes	142182|Gemmatimonadetes	D	Phage integrase, N-terminal SAM-like domain	xerC	-	-	ko:K03733	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
SHD1_k127_2121758_2	686340.Metal_0364	2.952e-32	136.0	COG1357@1|root,COG1357@2|Bacteria,1N7U9@1224|Proteobacteria,1RYAA@1236|Gammaproteobacteria,1XEVU@135618|Methylococcales	135618|Methylococcales	S	Pentapeptide repeats (9 copies)	-	-	-	-	-	-	-	-	-	-	-	-	Pentapeptide
SHD1_k127_2121758_0	251221.35210997	6.558e-107	354.0	COG1131@1|root,COG1131@2|Bacteria,1G0BQ@1117|Cyanobacteria	1117|Cyanobacteria	V	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
SHD1_k127_2121758_1	251221.35210998	8.177e-56	209.0	COG0842@1|root,COG0842@2|Bacteria	2|Bacteria	V	Transport permease protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_213293_3	861299.J421_2378	1.059e-11	70.0	2F43E@1|root,33WUY@2|Bacteria,1ZTT4@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_213293_2	861299.J421_2377	6.974e-56	206.0	COG1877@1|root,COG1877@2|Bacteria	2|Bacteria	G	trehalose biosynthetic process	otsB	-	3.1.3.12	ko:K01087	ko00500,ko01100,map00500,map01100	-	R02778	RC00017	ko00000,ko00001,ko01000	-	-	-	Trehalose_PPase
SHD1_k127_213293_0	861299.J421_2376	4.074e-195	620.0	COG0380@1|root,COG0380@2|Bacteria	2|Bacteria	G	alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity	otsA	-	2.4.1.15,2.4.1.245,2.4.1.347,2.5.1.135	ko:K00697,ko:K13057,ko:K20436	ko00500,ko00525,ko01100,ko01130,map00500,map00525,map01100,map01130	M00815	R02737,R08946,R10525,R11239,R11250,R11306,R11497	RC00005,RC00049,RC02748,RC03400,RC03401	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT20,GT4	-	Glyco_transf_20
SHD1_k127_213293_1	861299.J421_2375	1.645e-79	275.0	COG2605@1|root,COG2605@2|Bacteria,1ZTP2@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	GHMP kinases C terminal	-	-	2.7.1.168	ko:K07031	ko00540,map00540	-	R09770	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
SHD1_k127_2145940_1	861299.J421_2389	1.542e-63	219.0	COG0508@1|root,COG0508@2|Bacteria,1ZTB5@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2)	-	-	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
SHD1_k127_2145940_0	414684.RC1_2259	6.593e-152	495.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2TRN7@28211|Alphaproteobacteria,2JQ3A@204441|Rhodospirillales	204441|Rhodospirillales	C	COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes	lpd	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Biotin_lipoyl,Pyr_redox_2,Pyr_redox_dim
SHD1_k127_2151761_1	379066.GAU_3250	1.116e-68	248.0	COG0671@1|root,COG0671@2|Bacteria	2|Bacteria	I	phosphatidate phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	PAP2_3
SHD1_k127_2151761_2	861299.J421_0531	3.247e-46	169.0	COG0160@1|root,COG0739@1|root,COG2334@1|root,COG0160@2|Bacteria,COG0739@2|Bacteria,COG2334@2|Bacteria	2|Bacteria	S	homoserine kinase activity	gabT	-	2.6.1.19,2.6.1.22	ko:K00823,ko:K07250	ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648,R04188	RC00006,RC00062,RC00160	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	APH,Aminotran_3,Peptidase_M23
SHD1_k127_2151761_0	861299.J421_0531	2.849e-252	788.0	COG0160@1|root,COG0739@1|root,COG2334@1|root,COG0160@2|Bacteria,COG0739@2|Bacteria,COG2334@2|Bacteria	2|Bacteria	S	homoserine kinase activity	gabT	-	2.6.1.19,2.6.1.22	ko:K00823,ko:K07250	ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648,R04188	RC00006,RC00062,RC00160	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	APH,Aminotran_3,Peptidase_M23
SHD1_k127_2159237_7	479434.Sthe_1493	1.385e-20	99.0	COG0352@1|root,COG0352@2|Bacteria,2G9BW@200795|Chloroflexi,27YDG@189775|Thermomicrobia	189775|Thermomicrobia	H	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)	-	-	2.5.1.3	ko:K00788	ko00730,ko01100,map00730,map01100	M00127	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	TMP-TENI
SHD1_k127_2159237_2	861299.J421_2566	1.928e-113	378.0	COG0223@1|root,COG0223@2|Bacteria,1ZTE5@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
SHD1_k127_2159237_5	861299.J421_2567	1.024e-55	200.0	COG0242@1|root,COG0242@2|Bacteria,1ZTPP@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
SHD1_k127_2159237_6	379066.GAU_0626	1.301e-25	113.0	COG1862@1|root,COG1862@2|Bacteria,1ZU5F@142182|Gemmatimonadetes	142182|Gemmatimonadetes	U	Preprotein translocase subunit	-	-	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
SHD1_k127_2159237_0	861299.J421_2569	2.793e-166	531.0	COG0343@1|root,COG0343@2|Bacteria,1ZSRS@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	-	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
SHD1_k127_2159237_4	292459.STH1165	1.909e-95	337.0	COG0809@1|root,COG0809@2|Bacteria,1TPKD@1239|Firmicutes,247NT@186801|Clostridia	186801|Clostridia	J	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	queA	-	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
SHD1_k127_2159237_3	1379270.AUXF01000004_gene3255	2.814e-105	369.0	COG0457@1|root,COG0457@2|Bacteria	1379270.AUXF01000004_gene3255|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2159237_8	1242864.D187_009046	5.483e-13	80.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,1MWRF@1224|Proteobacteria,42P9S@68525|delta/epsilon subdivisions,2WJI7@28221|Deltaproteobacteria,2YTSQ@29|Myxococcales	28221|Deltaproteobacteria	H	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,TPR_10,TPR_12,TPR_7,TPR_8
SHD1_k127_2159237_1	861299.J421_2575	2.192e-134	432.0	COG2255@1|root,COG2255@2|Bacteria,1ZT9W@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
SHD1_k127_2161248_9	1047013.AQSP01000044_gene248	5.047e-05	47.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
SHD1_k127_2161248_7	911045.PSE_0855	1.59e-39	162.0	2DT0V@1|root,33I77@2|Bacteria,1NK6B@1224|Proteobacteria,2UM7W@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2161248_0	861299.J421_0817	3.667e-155	507.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
SHD1_k127_2161248_6	861299.J421_4134	2.42e-54	196.0	COG2197@1|root,COG2197@2|Bacteria,1ZV09@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KT	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE
SHD1_k127_2161248_4	861299.J421_4133	6.178e-58	207.0	2CB8S@1|root,30PE6@2|Bacteria,1ZV1Q@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Protein of unknown function (DUF4199)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4199
SHD1_k127_2161248_2	483219.LILAB_30160	2.502e-144	469.0	COG2059@1|root,COG2059@2|Bacteria,1MUBW@1224|Proteobacteria,42QCN@68525|delta/epsilon subdivisions,2WIYT@28221|Deltaproteobacteria,2YV4K@29|Myxococcales	28221|Deltaproteobacteria	P	Chromate transporter	chrA	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
SHD1_k127_2161248_5	287.DR97_2150	2.763e-56	203.0	COG0500@1|root,COG0500@2|Bacteria,1REJ2@1224|Proteobacteria,1S2QF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	Nodulation protein S (NodS)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
SHD1_k127_2161248_3	861299.J421_1920	4.159e-74	261.0	COG2197@1|root,COG2197@2|Bacteria,1ZSRV@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
SHD1_k127_2161248_8	309801.trd_1817	1.239e-12	79.0	COG4585@1|root,COG5000@1|root,COG4585@2|Bacteria,COG5000@2|Bacteria,2G7ZR@200795|Chloroflexi,27YV8@189775|Thermomicrobia	189775|Thermomicrobia	T	Histidine kinase	-	-	2.7.13.3	ko:K07675	ko02020,map02020	M00473	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA_3
SHD1_k127_2161248_1	861299.J421_1919	1.123e-154	496.0	COG2132@1|root,COG2132@2|Bacteria,1ZTWH@142182|Gemmatimonadetes	142182|Gemmatimonadetes	Q	Multicopper oxidase	-	-	1.16.3.3	ko:K22348	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_2,Cu-oxidase_3
SHD1_k127_2161412_5	861299.J421_5949	1.761e-115	404.0	COG0515@1|root,COG0515@2|Bacteria	861299.J421_5949|-	KLT	protein kinase activity	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	-
SHD1_k127_2161412_2	861299.J421_0460	1.184e-148	487.0	COG1807@1|root,COG1807@2|Bacteria,1ZUFB@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
SHD1_k127_2161412_4	861299.J421_1835	1.912e-118	387.0	COG3279@1|root,COG3279@2|Bacteria,1ZUKN@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	LytTr DNA-binding domain	-	-	-	ko:K02477	-	-	-	-	ko00000,ko02022	-	-	-	LytTR,Response_reg
SHD1_k127_2161412_6	861299.J421_1836	3.689e-98	337.0	COG2972@1|root,COG2972@2|Bacteria,1ZUUU@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	His_kinase
SHD1_k127_2161412_9	379066.GAU_0842	2.082e-31	133.0	COG1538@1|root,COG1538@2|Bacteria	2|Bacteria	MU	efflux transmembrane transporter activity	-	-	-	ko:K12340	ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133	M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko02044	1.B.17,2.A.6.2	-	-	OEP
SHD1_k127_2161412_7	861299.J421_1968	1.797e-47	180.0	COG0671@1|root,COG0671@2|Bacteria	2|Bacteria	I	phosphatidate phosphatase activity	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
SHD1_k127_2161412_1	861299.J421_0643	1.12e-150	492.0	COG4941@1|root,COG4941@2|Bacteria,1ZUFS@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
SHD1_k127_2161412_8	661478.OP10G_0325	4.632e-36	140.0	COG3795@1|root,COG3795@2|Bacteria	2|Bacteria	F	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	DoxX_2,YCII
SHD1_k127_2161412_3	1038860.AXAP01000027_gene1886	1.374e-137	458.0	COG0624@1|root,COG0624@2|Bacteria,1MWJS@1224|Proteobacteria,2TUHT@28211|Alphaproteobacteria,3JTSY@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Peptidase family M20/M25/M40	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
SHD1_k127_2161412_0	880073.Calab_3769	3.399e-232	739.0	COG1770@1|root,COG1770@2|Bacteria,2NNMF@2323|unclassified Bacteria	2|Bacteria	E	Prolyl oligopeptidase, N-terminal beta-propeller domain	ptrB	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0070011,GO:0070012,GO:0071704,GO:0140096,GO:1901564	3.4.21.83	ko:K01354	ko05142,ko05143,map05142,map05143	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
SHD1_k127_2168185_4	1340493.JNIF01000003_gene1601	5.183e-13	75.0	COG0358@1|root,COG0358@2|Bacteria	2|Bacteria	L	DNA primase activity	-	-	-	-	-	-	-	-	-	-	-	-	Toprim_2,Toprim_N,zf-CHC2
SHD1_k127_2168185_3	483219.LILAB_36660	4.361e-25	113.0	2BQNX@1|root,32JJ9@2|Bacteria,1PDBJ@1224|Proteobacteria,434Y3@68525|delta/epsilon subdivisions,2X92S@28221|Deltaproteobacteria,2Z1KV@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2168185_0	1254432.SCE1572_36055	1.099e-147	480.0	COG2801@1|root,COG2801@2|Bacteria,1R6TH@1224|Proteobacteria,42VCD@68525|delta/epsilon subdivisions,2WRUC@28221|Deltaproteobacteria,2YYTF@29|Myxococcales	28221|Deltaproteobacteria	L	COG2801 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32,Mu-transpos_C,rve
SHD1_k127_2168185_1	1254432.SCE1572_36050	3.343e-106	351.0	COG3267@1|root,COG3267@2|Bacteria,1REWJ@1224|Proteobacteria,42YV2@68525|delta/epsilon subdivisions,2WUIS@28221|Deltaproteobacteria,2Z0F4@29|Myxococcales	28221|Deltaproteobacteria	U	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22
SHD1_k127_2168185_2	467661.RKLH11_3891	9.175e-71	245.0	COG0358@1|root,COG0358@2|Bacteria,1MWSP@1224|Proteobacteria	1224|Proteobacteria	L	DNA primase	-	-	-	-	-	-	-	-	-	-	-	-	Toprim_2,Toprim_N,zf-CHC2
SHD1_k127_2168555_10	861299.J421_2881	9.512e-14	78.0	COG2812@1|root,COG2812@2|Bacteria,1ZTFV@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
SHD1_k127_2168555_9	861299.J421_2882	2.254e-34	134.0	COG0718@1|root,COG0718@2|Bacteria,1ZU1F@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection	-	-	-	ko:K09747	-	-	-	-	ko00000	-	-	-	YbaB_DNA_bd
SHD1_k127_2168555_5	1379270.AUXF01000005_gene387	3.006e-83	285.0	COG0353@1|root,COG0353@2|Bacteria,1ZTJX@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	-	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecR,Toprim_4
SHD1_k127_2168555_6	1379270.AUXF01000005_gene389	6.259e-73	248.0	COG2018@1|root,COG2018@2|Bacteria,1ZTK7@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Roadblock/LC7 domain	-	-	-	-	-	-	-	-	-	-	-	-	Robl_LC7
SHD1_k127_2168555_4	379066.GAU_1116	6.763e-118	382.0	COG1100@1|root,COG1100@2|Bacteria,1ZSQI@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	ADP-ribosylation factor family	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	Arf
SHD1_k127_2168555_7	379066.GAU_1117	1.603e-65	231.0	COG0558@1|root,COG0558@2|Bacteria,1ZSXG@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	CDP-alcohol phosphatidyltransferase	-	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
SHD1_k127_2168555_2	379066.GAU_1122	4.795e-151	492.0	COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,1ZSS9@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Competence-damaged protein	-	-	3.5.1.42	ko:K03742	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA,MoCF_biosynth
SHD1_k127_2168555_8	861299.J421_2889	1.089e-53	194.0	COG0576@1|root,COG0576@2|Bacteria,1ZTSJ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
SHD1_k127_2168555_1	1379270.AUXF01000005_gene395	5.443e-152	489.0	COG0484@1|root,COG0484@2|Bacteria,1ZT5T@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	-	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
SHD1_k127_2168555_3	1128421.JAGA01000003_gene3727	3.561e-145	467.0	COG0274@1|root,COG0274@2|Bacteria	2|Bacteria	F	deoxyribose-phosphate aldolase activity	deoC	-	4.1.2.4	ko:K01619	ko00030,map00030	-	R01066	RC00436,RC00437	ko00000,ko00001,ko01000	-	-	-	DeoC
SHD1_k127_2168555_0	861299.J421_3024	6.794e-240	751.0	COG1012@1|root,COG1012@2|Bacteria,1ZT7A@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Aldehyde dehydrogenase family	-	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
SHD1_k127_2172747_2	861299.J421_3068	6.53e-46	167.0	COG0275@1|root,COG0275@2|Bacteria,1ZT4V@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	-	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
SHD1_k127_2172747_3	861299.J421_3069	1.963e-13	76.0	29F5Y@1|root,3023N@2|Bacteria,1ZU6W@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2172747_0	861299.J421_3070	3.974e-187	606.0	COG0768@1|root,COG0768@2|Bacteria,1ZSYD@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	Penicillin binding protein transpeptidase domain	-	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PBP_dimer,Transpeptidase
SHD1_k127_2172747_1	1379270.AUXF01000005_gene685	4.086e-129	426.0	COG0769@1|root,COG0769@2|Bacteria,1ZSS3@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
SHD1_k127_2182367_1	1449976.KALB_3913	6.931e-49	186.0	COG0531@1|root,COG0531@2|Bacteria,2GM7G@201174|Actinobacteria,4DZKR@85010|Pseudonocardiales	201174|Actinobacteria	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
SHD1_k127_2182367_0	861299.J421_3387	4.424e-271	840.0	COG0519@1|root,COG0519@2|Bacteria,1ZSMF@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Catalyzes the synthesis of GMP from XMP	guaA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
SHD1_k127_2182367_2	1379270.AUXF01000006_gene143	1.464e-27	113.0	COG0622@1|root,COG0622@2|Bacteria,1ZTPR@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	ko:K07095	-	-	-	-	ko00000	-	-	-	Metallophos_2
SHD1_k127_2183699_27	290398.Csal_1299	3.345e-20	103.0	COG3528@1|root,COG3528@2|Bacteria,1R601@1224|Proteobacteria,1S150@1236|Gammaproteobacteria,1XJ22@135619|Oceanospirillales	135619|Oceanospirillales	S	Uncharacterized protein conserved in bacteria (DUF2219)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2219
SHD1_k127_2183699_12	861299.J421_4427	4.032e-108	359.0	COG2017@1|root,COG2017@2|Bacteria	2|Bacteria	G	converts alpha-aldose to the beta-anomer	-	-	-	-	-	-	-	-	-	-	-	-	Aldose_epim,DUF4432,DUF5107
SHD1_k127_2183699_4	861299.J421_4428	7.882e-191	604.0	COG0761@1|root,COG0761@2|Bacteria,1ZTGU@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	LytB protein	-	-	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	-	LYTB
SHD1_k127_2183699_21	1341151.ASZU01000025_gene2986	1.325e-48	186.0	COG1619@1|root,COG1619@2|Bacteria,1TRBB@1239|Firmicutes,4HAWT@91061|Bacilli,27B0F@186824|Thermoactinomycetaceae	91061|Bacilli	V	LD-carboxypeptidase	ykfA	-	3.4.17.13	ko:K01297	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_S66
SHD1_k127_2183699_20	1158760.AQXP01000054_gene1638	7.205e-49	182.0	COG2110@1|root,COG2110@2|Bacteria,1RCWP@1224|Proteobacteria,1S3WJ@1236|Gammaproteobacteria,1WYF4@135613|Chromatiales	135613|Chromatiales	S	PFAM Appr-1-p processing domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Macro
SHD1_k127_2183699_10	861299.J421_6171	2.553e-118	393.0	COG0642@1|root,COG2205@2|Bacteria	861299.J421_6171|-	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2183699_24	1379270.AUXF01000001_gene2573	1.99e-27	116.0	COG0824@1|root,COG0824@2|Bacteria,1ZV5K@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Thioesterase superfamily	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT
SHD1_k127_2183699_9	379066.GAU_2556	1.02e-154	496.0	COG0189@1|root,COG0189@2|Bacteria,1ZU94@142182|Gemmatimonadetes	142182|Gemmatimonadetes	HJ	Carbamoyl-phosphate synthase L chain, ATP binding domain	-	-	-	-	-	-	-	-	-	-	-	-	CPSase_L_D2
SHD1_k127_2183699_8	379066.GAU_2555	2.026e-168	554.0	COG2141@1|root,COG2141@2|Bacteria,1ZURX@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Luciferase-like monooxygenase	-	-	1.14.14.35	ko:K17228	ko00920,map00920	-	R10203	RC02556,RC03080	ko00000,ko00001,ko01000	-	-	-	Bac_luciferase
SHD1_k127_2183699_28	1123368.AUIS01000007_gene2801	9.591e-20	96.0	COG5501@1|root,COG5501@2|Bacteria,1RH4J@1224|Proteobacteria,1S4ZT@1236|Gammaproteobacteria,2NCUM@225057|Acidithiobacillales	225057|Acidithiobacillales	S	Sulfur oxidation protein SoxY	-	-	-	ko:K17226	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	SoxY,TAT_signal
SHD1_k127_2183699_26	156889.Mmc1_3715	4.234e-21	100.0	COG2033@1|root,COG2033@2|Bacteria,1QVWP@1224|Proteobacteria,2TWVW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Sulphur oxidation protein SoxZ	-	-	-	ko:K17227	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	SoxZ
SHD1_k127_2183699_22	932678.THERU_04690	5.415e-36	151.0	COG0491@1|root,COG0491@2|Bacteria	2|Bacteria	GM	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
SHD1_k127_2183699_14	861299.J421_4430	7.995e-89	297.0	COG5516@1|root,COG5516@2|Bacteria,1ZTJN@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Putative stress-induced transcription regulator	-	-	-	-	-	-	-	-	-	-	-	-	ABATE,zf-CGNR
SHD1_k127_2183699_15	1379270.AUXF01000001_gene2568	2.699e-87	296.0	COG1595@1|root,COG1595@2|Bacteria,1ZV3I@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
SHD1_k127_2183699_17	1379270.AUXF01000001_gene2567	2.939e-61	218.0	COG1309@1|root,COG1309@2|Bacteria,1ZV9M@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Bacterial transcriptional repressor C-terminal	-	-	-	ko:K16137	-	-	-	-	ko00000,ko03000	-	-	-	TetR_C_13,TetR_N
SHD1_k127_2183699_18	251229.Chro_0773	2.809e-54	195.0	COG0454@1|root,COG0456@2|Bacteria,1GQNY@1117|Cyanobacteria	1117|Cyanobacteria	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
SHD1_k127_2183699_0	861299.J421_4433	0.0	1179.0	COG1643@1|root,COG1643@2|Bacteria,1ZSN8@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	Atp-dependent helicase	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2183699_29	861299.J421_4434	8.115e-15	85.0	2DWK2@1|root,340S5@2|Bacteria,1ZTSX@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2183699_31	1121918.ARWE01000001_gene3537	8.735e-06	54.0	COG3222@1|root,COG3222@2|Bacteria,1RB1V@1224|Proteobacteria,42U9T@68525|delta/epsilon subdivisions,2WQPQ@28221|Deltaproteobacteria,43W3W@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2064)	-	-	-	ko:K09931	-	-	-	-	ko00000	-	-	-	DUF2064
SHD1_k127_2183699_7	861299.J421_4435	7.387e-174	553.0	COG0205@1|root,COG0205@2|Bacteria,1ZTAR@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	pfkA	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
SHD1_k127_2183699_30	861299.J421_4437	1.14e-12	74.0	COG4970@1|root,COG4970@2|Bacteria,1ZU5N@142182|Gemmatimonadetes	142182|Gemmatimonadetes	NU	Tfp pilus assembly protein FimT	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2183699_5	861299.J421_4442	1.793e-182	582.0	COG0513@1|root,COG0513@2|Bacteria,1ZSX8@142182|Gemmatimonadetes	142182|Gemmatimonadetes	JKL	DEAD-like helicases superfamily	-	-	3.6.4.13	ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DEAD,Helicase_C
SHD1_k127_2183699_13	1379270.AUXF01000001_gene2561	2.621e-97	332.0	2EW3S@1|root,33PH0@2|Bacteria,1ZTQG@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2183699_3	1121920.AUAU01000023_gene2395	9.123e-234	742.0	COG0065@1|root,COG0066@1|root,COG0065@2|Bacteria,COG0066@2|Bacteria	2|Bacteria	E	3-isopropylmalate dehydratase activity	leuD	-	4.2.1.3,4.2.1.33,4.2.1.35	ko:K01681,ko:K01703,ko:K01704,ko:K17749	ko00020,ko00290,ko00400,ko00630,ko00660,ko00720,ko00966,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00290,map00400,map00630,map00660,map00720,map00966,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00432,M00535,M00740	R01324,R01325,R01900,R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170,R10501	RC00497,RC00498,RC00618,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
SHD1_k127_2183699_11	861299.J421_4446	9.05e-110	382.0	COG2267@1|root,COG2267@2|Bacteria,1ZTN9@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
SHD1_k127_2183699_23	861299.J421_4447	5.826e-30	132.0	COG4783@1|root,COG4783@2|Bacteria,1ZU5G@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	chaperone-mediated protein folding	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2183699_2	861299.J421_1389	5.211e-277	877.0	COG2234@1|root,COG2234@2|Bacteria,1ZSQ8@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Nicastrin	-	-	3.4.17.21	ko:K01301	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PA,Peptidase_M28,TFR_dimer
SHD1_k127_2183699_16	1089548.KI783301_gene3201	4.312e-74	265.0	COG1306@1|root,COG1306@2|Bacteria,1TQZV@1239|Firmicutes,4HAPK@91061|Bacilli	91061|Bacilli	S	GTP-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF4015
SHD1_k127_2183699_6	1453501.JELR01000002_gene529	1.436e-180	588.0	COG4805@1|root,COG4805@2|Bacteria,1MUBX@1224|Proteobacteria,1RMT7@1236|Gammaproteobacteria,466B9@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
SHD1_k127_2183699_1	861299.J421_1696	8.44e-295	925.0	COG2866@1|root,COG2866@2|Bacteria,1ZUNB@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Zinc carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
SHD1_k127_2183699_19	861299.J421_4448	7.325e-54	201.0	COG0515@1|root,COG0515@2|Bacteria,1ZTGN@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	Protein kinase domain	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
SHD1_k127_2188521_4	1379270.AUXF01000001_gene2805	3.16e-34	136.0	COG0644@1|root,COG0644@2|Bacteria,1ZTEM@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Glucose inhibited division protein A	-	-	1.3.99.38	ko:K21401	-	-	-	-	ko00000,ko01000	-	-	-	FAD_binding_3
SHD1_k127_2188521_3	861299.J421_4182	1.091e-52	197.0	COG1853@1|root,COG1853@2|Bacteria,1ZTVB@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Flavin reductase like domain	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
SHD1_k127_2188521_1	861299.J421_4183	1.711e-63	231.0	COG0500@1|root,COG2226@2|Bacteria,1ZTP4@142182|Gemmatimonadetes	142182|Gemmatimonadetes	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
SHD1_k127_2188521_2	379066.GAU_2590	2.645e-57	214.0	COG2867@1|root,COG2867@2|Bacteria,1ZTVW@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc
SHD1_k127_2188521_0	861299.J421_4185	1.133e-187	595.0	COG0304@1|root,COG0304@2|Bacteria,1ZTE1@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	-	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
SHD1_k127_2191094_0	1379270.AUXF01000002_gene1364	9.008e-56	215.0	COG0515@1|root,COG0515@2|Bacteria	1379270.AUXF01000002_gene1364|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2191094_1	159087.Daro_1105	8.651e-23	109.0	COG4886@1|root,COG4886@2|Bacteria	2|Bacteria	S	regulation of response to stimulus	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,CUB,DUF285,Flg_new,LRR_5,LRR_6,PKD
SHD1_k127_2211795_0	861299.J421_2582	2.833e-263	819.0	COG0745@1|root,COG0745@2|Bacteria,1ZTEW@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KT	PglZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PglZ,Response_reg
SHD1_k127_2211795_1	861299.J421_2583	2.256e-221	705.0	COG1132@1|root,COG1132@2|Bacteria,1ZT2T@142182|Gemmatimonadetes	142182|Gemmatimonadetes	V	ABC transporter transmembrane region	-	-	-	ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106	-	-	ABC_membrane,ABC_tran
SHD1_k127_2211795_5	861299.J421_2584	7.443e-68	246.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	treT	-	2.4.1.245	ko:K13057	ko00500,ko01100,map00500,map01100	-	R08946,R10525,R11306	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000	-	GT4	-	Glycos_transf_1
SHD1_k127_2211795_3	861299.J421_2586	6.217e-97	327.0	COG1560@1|root,COG1560@2|Bacteria,1ZSTD@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	Bacterial lipid A biosynthesis acyltransferase	-	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
SHD1_k127_2211795_2	861299.J421_2587	1.708e-118	405.0	COG1173@1|root,COG1173@2|Bacteria,1ZT0U@142182|Gemmatimonadetes	142182|Gemmatimonadetes	EP	N-terminal TM domain of oligopeptide transport permease C	-	-	-	ko:K02034,ko:K15582	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1,OppC_N
SHD1_k127_2211795_4	379066.GAU_0642	7.42e-96	332.0	COG0520@1|root,COG0520@2|Bacteria,1ZTDV@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
SHD1_k127_2214019_1	448385.sce9042	3.48e-56	202.0	COG1073@1|root,COG1926@1|root,COG1073@2|Bacteria,COG1926@2|Bacteria,1RDAY@1224|Proteobacteria,43CWS@68525|delta/epsilon subdivisions,2X84R@28221|Deltaproteobacteria,2YX1U@29|Myxococcales	28221|Deltaproteobacteria	S	Phosphoribosyl transferase domain	-	-	-	ko:K07100	-	-	-	-	ko00000	-	-	-	Pribosyltran
SHD1_k127_2214019_0	314345.SPV1_13177	3.01e-78	272.0	COG0668@1|root,COG0668@2|Bacteria,1MXD2@1224|Proteobacteria	1224|Proteobacteria	M	mechanosensitive ion channel	ynaI	-	-	ko:K22044	-	-	-	-	ko00000,ko02000	1.A.23.3	-	-	MS_channel
SHD1_k127_2222612_1	667632.KB890165_gene2438	2.799e-09	60.0	COG3847@1|root,COG3847@2|Bacteria	2|Bacteria	U	Flp Fap pilin component	pilA	-	-	ko:K02651	ko04112,map04112	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	Flp_Fap
SHD1_k127_2234681_2	861299.J421_3338	2.464e-28	114.0	COG1530@1|root,COG1530@2|Bacteria,1ZSZS@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Ribonuclease E/G family	-	-	-	ko:K08301	-	-	-	-	ko00000,ko01000,ko03009,ko03019	-	-	-	RNase_E_G
SHD1_k127_2234681_0	861299.J421_3337	1.97e-45	166.0	COG0261@1|root,COG0261@2|Bacteria,1ZTS8@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	This protein binds to 23S rRNA in the presence of protein L20	rplU	-	-	ko:K02888	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21p
SHD1_k127_2234681_1	861299.J421_3336	2.013e-39	148.0	COG0211@1|root,COG0211@2|Bacteria,1ZTXX@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Ribosomal L27 protein	rpmA	-	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
SHD1_k127_2240728_4	861299.J421_3762	7.955e-54	196.0	COG0648@1|root,COG0648@2|Bacteria,1ZSY0@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin	nfo	-	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
SHD1_k127_2240728_0	379066.GAU_2162	5.707e-116	392.0	COG4942@1|root,COG4942@2|Bacteria,1ZSU6@142182|Gemmatimonadetes	142182|Gemmatimonadetes	D	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
SHD1_k127_2240728_1	861299.J421_3760	8.524e-94	315.0	COG2177@1|root,COG2177@2|Bacteria,1ZTDR@142182|Gemmatimonadetes	142182|Gemmatimonadetes	D	Part of the ABC transporter FtsEX involved in	-	-	-	ko:K09811	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	-
SHD1_k127_2240728_2	861299.J421_3759	2.255e-84	287.0	COG2884@1|root,COG2884@2|Bacteria,1ZTHQ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	D	ABC transporter	-	-	-	ko:K09812	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	ABC_tran
SHD1_k127_2240728_3	861299.J421_3758	5.064e-83	278.0	COG0626@1|root,COG0626@2|Bacteria,1ZUSY@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Cys/Met metabolism PLP-dependent enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Cys_Met_Meta_PP
SHD1_k127_2243689_6	861299.J421_3230	1.294e-21	109.0	COG0728@1|root,COG0728@2|Bacteria,1ZTCM@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
SHD1_k127_2243689_1	861299.J421_3229	1.245e-125	421.0	COG4365@1|root,COG4365@2|Bacteria,1ZTG0@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Bacillithiol biosynthesis BshC	-	-	-	ko:K22136	-	-	-	-	ko00000	-	-	-	BshC
SHD1_k127_2243689_5	861299.J421_3228	3.767e-47	173.0	COG1576@1|root,COG1576@2|Bacteria,1ZTQJ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA	rlmH	-	2.1.1.177	ko:K00783	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SPOUT_MTase
SHD1_k127_2243689_0	1379270.AUXF01000006_gene294	1.226e-226	707.0	COG0334@1|root,COG0334@2|Bacteria,1ZSQB@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase	-	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
SHD1_k127_2243689_3	861299.J421_3226	1.87e-92	314.0	COG1663@1|root,COG1663@2|Bacteria,1ZTIE@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)	lpxK	-	2.7.1.130	ko:K00912	ko00540,ko01100,map00540,map01100	M00060	R04657	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxK
SHD1_k127_2243689_4	861299.J421_3225	2.734e-57	209.0	COG2121@1|root,COG2121@2|Bacteria,1ZTU5@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Domain of unknown function (DUF374)	-	-	-	ko:K09778	-	-	-	-	ko00000	-	-	-	DUF374
SHD1_k127_2243689_2	861299.J421_3224	2.808e-112	372.0	COG0763@1|root,COG0763@2|Bacteria,1ZTAD@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	-	-	2.4.1.182	ko:K00748	ko00540,ko01100,map00540,map01100	M00060	R04606	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT19	-	LpxB
SHD1_k127_2244354_1	861299.J421_1128	2.617e-172	576.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
SHD1_k127_2244354_21	861299.J421_1785	1.431e-36	142.0	COG1695@1|root,COG1695@2|Bacteria	2|Bacteria	K	negative regulation of transcription, DNA-templated	-	-	-	-	-	-	-	-	-	-	-	-	PadR
SHD1_k127_2244354_23	861299.J421_1390	5.835e-34	138.0	COG2318@1|root,COG2318@2|Bacteria,1ZV4X@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2244354_8	404589.Anae109_2572	2.486e-67	237.0	COG1573@1|root,COG1573@2|Bacteria,1MW8T@1224|Proteobacteria,42ZZ6@68525|delta/epsilon subdivisions,2WV5A@28221|Deltaproteobacteria,2YZAW@29|Myxococcales	28221|Deltaproteobacteria	L	Uracil DNA glycosylase superfamily	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
SHD1_k127_2244354_16	266940.Krad_0105	1.696e-50	194.0	COG2141@1|root,COG2141@2|Bacteria,2I29H@201174|Actinobacteria	201174|Actinobacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2244354_22	715226.ABI_28870	4.791e-34	151.0	COG2972@1|root,COG2972@2|Bacteria,1MXVQ@1224|Proteobacteria,2U16F@28211|Alphaproteobacteria,2KI46@204458|Caulobacterales	204458|Caulobacterales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	His_kinase
SHD1_k127_2244354_15	861299.J421_6004	1.214e-54	200.0	COG3279@1|root,COG3279@2|Bacteria,1ZUUN@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	LytTr DNA-binding domain	-	-	-	ko:K02477	-	-	-	-	ko00000,ko02022	-	-	-	LytTR,Response_reg
SHD1_k127_2244354_18	204669.Acid345_1709	1.098e-48	198.0	COG0491@1|root,COG0491@2|Bacteria,3Y4D7@57723|Acidobacteria,2JKB5@204432|Acidobacteriia	204432|Acidobacteriia	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
SHD1_k127_2244354_20	452637.Oter_2930	2.672e-40	154.0	COG2193@1|root,COG2193@2|Bacteria,46V17@74201|Verrucomicrobia	74201|Verrucomicrobia	P	PFAM Ferritin Dps family protein	-	-	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
SHD1_k127_2244354_17	1210884.HG799465_gene12237	3.762e-49	181.0	COG0662@1|root,COG0662@2|Bacteria,2J42S@203682|Planctomycetes	203682|Planctomycetes	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
SHD1_k127_2244354_32	1165841.SULAR_02558	2.599e-05	49.0	2DNSI@1|root,32YXC@2|Bacteria,1N7K2@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2244354_7	379066.GAU_3743	1.902e-70	245.0	COG1739@1|root,COG1739@2|Bacteria,1ZTND@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Domain of unknown function (DUF1949)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1949,UPF0029
SHD1_k127_2244354_11	1379270.AUXF01000007_gene863	7.593e-63	222.0	COG4681@1|root,COG4681@2|Bacteria,1ZUJK@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	YaeQ	-	-	-	-	-	-	-	-	-	-	-	-	YaeQ
SHD1_k127_2244354_14	861299.J421_6331	6.113e-56	201.0	COG1403@1|root,COG1403@2|Bacteria	2|Bacteria	V	endonuclease activity	-	-	-	-	-	-	-	-	-	-	-	-	HNH,HNH_5
SHD1_k127_2244354_25	379066.GAU_3650	3.912e-31	129.0	COG2318@1|root,COG2318@2|Bacteria	2|Bacteria	S	DinB family	yisT	-	-	-	-	-	-	-	-	-	-	-	DUF664,DinB
SHD1_k127_2244354_29	1123073.KB899241_gene2311	3.557e-10	68.0	2DWEZ@1|root,33ZZS@2|Bacteria,1NYBC@1224|Proteobacteria,1SQSQ@1236|Gammaproteobacteria,1XAUU@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2244354_5	861299.J421_0328	2.83e-94	316.0	COG2041@1|root,COG2041@2|Bacteria,1ZUNH@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Oxidoreductase molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_molyb
SHD1_k127_2244354_3	861299.J421_0327	6.686e-111	364.0	COG4117@1|root,COG4117@2|Bacteria,1ZUUH@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Prokaryotic cytochrome b561	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB
SHD1_k127_2244354_9	1121459.AQXE01000002_gene1400	6.389e-66	232.0	COG0225@1|root,COG0229@1|root,COG0225@2|Bacteria,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria	1224|Proteobacteria	O	methionine sulfoxide reductase	msrB	GO:0003674,GO:0003824,GO:0008113,GO:0008150,GO:0008152,GO:0009405,GO:0016491,GO:0016667,GO:0016671,GO:0044419,GO:0051704,GO:0055114	1.8.4.11,1.8.4.12	ko:K07305,ko:K12267	-	-	-	-	ko00000,ko01000	-	-	-	PMSR,SelR
SHD1_k127_2244354_4	215803.DB30_5985	2.199e-108	364.0	COG1680@1|root,COG1680@2|Bacteria,1MVPR@1224|Proteobacteria,42TQ5@68525|delta/epsilon subdivisions,2WQ0T@28221|Deltaproteobacteria,2YZ88@29|Myxococcales	28221|Deltaproteobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
SHD1_k127_2244354_6	765420.OSCT_2525	1.57e-76	267.0	COG0572@1|root,COG0572@2|Bacteria	2|Bacteria	F	uridine kinase	prk	-	2.7.1.19	ko:K00855	ko00710,ko01100,ko01120,ko01200,map00710,map01100,map01120,map01200	M00165,M00166	R01523	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PRK
SHD1_k127_2244354_10	666685.R2APBS1_0473	1.024e-65	238.0	COG4099@1|root,COG4099@2|Bacteria,1RHBS@1224|Proteobacteria,1T15X@1236|Gammaproteobacteria,1XD38@135614|Xanthomonadales	135614|Xanthomonadales	S	Esterase PHB depolymerase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S9
SHD1_k127_2244354_12	861299.J421_3958	4.246e-62	223.0	COG3871@1|root,COG3871@2|Bacteria	2|Bacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	1.4.3.5	ko:K00275	ko00750,ko01100,ko01120,map00750,map01100,map01120	M00124	R00277,R00278,R01710,R01711	RC00048,RC00116	ko00000,ko00001,ko00002,ko01000	-	-	-	Pyrid_ox_like
SHD1_k127_2244354_19	1210884.HG799465_gene11339	7.69e-42	162.0	COG0262@1|root,COG0262@2|Bacteria,2J1IB@203682|Planctomycetes	203682|Planctomycetes	H	RibD C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
SHD1_k127_2244354_30	861299.J421_0718	7.958e-07	57.0	2F4AY@1|root,33X1J@2|Bacteria,1ZTWF@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2244354_0	861299.J421_1702	5.454e-213	676.0	COG3653@1|root,COG3653@2|Bacteria,1ZTDH@142182|Gemmatimonadetes	142182|Gemmatimonadetes	Q	Amidohydrolase family	-	-	3.5.1.81	ko:K06015	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Amidohydro_3
SHD1_k127_2244354_33	1396141.BATP01000018_gene1546	0.0002024	51.0	COG4319@1|root,COG4319@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	ABM,DUF3225,DUF4440,SnoaL_2,SnoaL_3
SHD1_k127_2244354_13	1123242.JH636435_gene1221	5.547e-61	218.0	COG0580@1|root,COG0580@2|Bacteria,2IZDN@203682|Planctomycetes	203682|Planctomycetes	U	Belongs to the MIP aquaporin (TC 1.A.8) family	-	-	-	ko:K06188	-	-	-	-	ko00000,ko02000	1.A.8	-	-	MIP
SHD1_k127_2244354_24	861299.J421_1898	1.131e-33	134.0	COG3668@1|root,32ZH9@2|Bacteria	2|Bacteria	S	COG3668 Plasmid stabilization system protein	osmB	-	-	-	-	-	-	-	-	-	-	-	Rho_N
SHD1_k127_2244354_2	928724.SacglDRAFT_02131	3.683e-133	435.0	COG0535@1|root,COG0535@2|Bacteria,2HGKW@201174|Actinobacteria,4DZZI@85010|Pseudonocardiales	201174|Actinobacteria	S	biosynthesis protein E	pqqE	-	-	ko:K06139	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SPASM
SHD1_k127_2244354_27	1380390.JIAT01000010_gene4341	7.085e-17	84.0	2E4CK@1|root,32Z81@2|Bacteria	2|Bacteria	S	pyrroloquinoline quinone biosynthesis protein D	pqqD	GO:0006082,GO:0006464,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0018130,GO:0018189,GO:0018193,GO:0018212,GO:0019538,GO:0019752,GO:0034641,GO:0036211,GO:0042180,GO:0042181,GO:0042364,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072350,GO:0072351,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901661,GO:1901663	-	ko:K06138	-	-	-	-	ko00000	-	-	-	PqqD
SHD1_k127_2244354_26	1484157.PSNIH2_18465	1.242e-23	102.0	COG5424@1|root,COG5424@2|Bacteria,1MW7G@1224|Proteobacteria,1RP1V@1236|Gammaproteobacteria,3VXW3@53335|Pantoea	1236|Gammaproteobacteria	H	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ	pqqC	-	1.3.3.11	ko:K06137	-	-	-	-	ko00000,ko01000	-	-	-	TENA_THI-4
SHD1_k127_2254743_4	1196835.A458_10825	4.893e-32	134.0	294MD@1|root,2ZS0U@2|Bacteria,1NEY7@1224|Proteobacteria,1SFSY@1236|Gammaproteobacteria,1Z1FX@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2254743_2	62928.azo1214	2.759e-48	178.0	2BNJ1@1|root,32H7S@2|Bacteria,1PJNQ@1224|Proteobacteria,2W82I@28216|Betaproteobacteria,2KZE3@206389|Rhodocyclales	206389|Rhodocyclales	S	Protein of unknown function (DUF1097)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1097
SHD1_k127_2254743_1	886293.Sinac_3107	3.376e-55	198.0	COG3795@1|root,COG3795@2|Bacteria,2IZ9F@203682|Planctomycetes	203682|Planctomycetes	K	PFAM YCII-related	-	-	-	-	-	-	-	-	-	-	-	-	YCII
SHD1_k127_2254743_3	479434.Sthe_2956	4.75e-33	132.0	COG0346@1|root,COG0346@2|Bacteria,2G7HN@200795|Chloroflexi	200795|Chloroflexi	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
SHD1_k127_2254743_0	1254432.SCE1572_38000	4.034e-209	655.0	COG4941@1|root,COG4941@2|Bacteria,1MU3D@1224|Proteobacteria,437V1@68525|delta/epsilon subdivisions,2X34I@28221|Deltaproteobacteria,2YU7X@29|Myxococcales	28221|Deltaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
SHD1_k127_2263396_0	543728.Vapar_1655	2.533e-51	186.0	COG0053@1|root,COG0053@2|Bacteria,1MVH8@1224|Proteobacteria,2VNZ1@28216|Betaproteobacteria,4AG57@80864|Comamonadaceae	28216|Betaproteobacteria	P	Cation efflux family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux
SHD1_k127_2263396_1	211165.AJLN01000040_gene6399	2.454e-33	148.0	COG0642@1|root,COG0745@1|root,COG0784@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG2205@2|Bacteria,1G09B@1117|Cyanobacteria,1JK6C@1189|Stigonemataceae	1117|Cyanobacteria	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
SHD1_k127_2267705_0	1356854.N007_14115	1.575e-165	524.0	COG0667@1|root,COG0667@2|Bacteria,1TQJC@1239|Firmicutes,4HC0W@91061|Bacilli	91061|Bacilli	C	Aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
SHD1_k127_2267707_0	504472.Slin_5713	4.003e-277	878.0	COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,4NGU2@976|Bacteroidetes,47NFD@768503|Cytophagia	976|Bacteroidetes	M	Tricorn protease homolog	-	-	-	-	-	-	-	-	-	-	-	-	GRASP55_65,PD40,PDZ_2,Peptidase_S41,Tricorn_C1
SHD1_k127_2267707_1	861299.J421_2435	3.738e-244	764.0	COG0477@1|root,COG0477@2|Bacteria,1ZT3N@142182|Gemmatimonadetes	2|Bacteria	U	Sugar (and other) transporter	emrB	-	-	ko:K03446	-	M00701	-	-	ko00000,ko00002,ko02000	2.A.1.3	-	-	MFS_1
SHD1_k127_2267707_5	543728.Vapar_5238	3.383e-12	78.0	2DNFD@1|root,32X82@2|Bacteria,1QYH7@1224|Proteobacteria,2WHWJ@28216|Betaproteobacteria	28216|Betaproteobacteria	S	DoxX-like family	-	-	-	-	-	-	-	-	-	-	-	-	DoxX_2
SHD1_k127_2267707_4	518766.Rmar_1861	1.115e-50	196.0	COG2972@1|root,COG2972@2|Bacteria,4NK4J@976|Bacteroidetes,1FIPJ@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,His_kinase
SHD1_k127_2267707_3	1267535.KB906767_gene1118	5.611e-74	259.0	COG3279@1|root,COG3279@2|Bacteria,3Y4VI@57723|Acidobacteria,2JJIJ@204432|Acidobacteriia	204432|Acidobacteriia	T	LytTr DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	LytTR,Response_reg
SHD1_k127_2267707_6	234621.RER_53660	1.543e-05	53.0	COG3794@1|root,COG3794@2|Bacteria,2GSBM@201174|Actinobacteria,4G2JT@85025|Nocardiaceae	201174|Actinobacteria	C	Copper binding proteins, plastocyanin/azurin family	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cupredoxin_1
SHD1_k127_2267707_7	1033738.CAEP01000174_gene762	1.575e-05	55.0	COG5492@1|root,COG5492@2|Bacteria,1VBT6@1239|Firmicutes,4I2FS@91061|Bacilli,26HYQ@186818|Planococcaceae	1239|Firmicutes	N	Bacterial Ig-like domain 2	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,Flg_new,LRR_5,fn3
SHD1_k127_2267707_2	379066.GAU_2989	1.651e-120	404.0	COG1538@1|root,COG1538@2|Bacteria,1ZUTU@142182|Gemmatimonadetes	142182|Gemmatimonadetes	MU	Outer membrane efflux protein	-	-	-	ko:K18139	ko01501,ko02024,map01501,map02024	M00642,M00643,M00647,M00718,M00768,M00822	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	1.B.17,2.A.6.2	-	-	OEP
SHD1_k127_2271731_15	880526.KE386488_gene884	1.963e-26	110.0	COG3340@1|root,COG3340@2|Bacteria,4NEXW@976|Bacteroidetes,2FQTC@200643|Bacteroidia,22U8N@171550|Rikenellaceae	976|Bacteroidetes	E	Belongs to the peptidase S51 family	pepE	-	3.4.13.21	ko:K05995	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S51
SHD1_k127_2271731_14	1379270.AUXF01000001_gene2747	1.45e-28	127.0	COG1196@1|root,COG1196@2|Bacteria,1ZU2U@142182|Gemmatimonadetes	142182|Gemmatimonadetes	D	nuclear chromosome segregation	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2271731_8	1121035.AUCH01000005_gene125	2.506e-71	252.0	COG2199@1|root,COG3706@2|Bacteria,1MYK0@1224|Proteobacteria	1224|Proteobacteria	T	COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Response_reg
SHD1_k127_2271731_7	234267.Acid_0426	6.984e-87	300.0	COG3829@1|root,COG3829@2|Bacteria,3Y988@57723|Acidobacteria	57723|Acidobacteria	K	Sigma-54 interaction domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,PAS_9,Sigma54_activat
SHD1_k127_2271731_6	861299.J421_3802	2.817e-97	326.0	COG2367@1|root,COG2367@2|Bacteria	2|Bacteria	V	Beta-lactamase	-	-	3.5.2.6	ko:K17836	ko00311,ko01130,ko01501,map00311,map01130,map01501	M00627,M00628	R06363	RC01499	ko00000,ko00001,ko00002,ko01000,ko01504	-	-	-	Beta-lactamase2
SHD1_k127_2271731_17	861299.J421_3801	5.392e-15	85.0	2960H@1|root,2ZTB5@2|Bacteria,1ZU7H@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2271731_1	1379270.AUXF01000003_gene3650	3.273e-142	467.0	COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1ZSX0@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	Transglycosylase SLT domain	-	-	-	ko:K08307	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	LysM,SLT
SHD1_k127_2271731_11	861299.J421_3799	5.328e-48	180.0	COG0741@1|root,COG0741@2|Bacteria,1ZTV6@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	Transglycosylase SLT domain	-	-	-	-	-	-	-	-	-	-	-	-	SLT
SHD1_k127_2271731_10	861299.J421_3798	7.25e-52	192.0	COG0315@1|root,COG0315@2|Bacteria,1ZU6G@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
SHD1_k127_2271731_5	861299.J421_3797	1.335e-101	343.0	COG0470@1|root,COG0470@2|Bacteria,1ZT21@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	DNA polymerase III, delta subunit	-	-	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2
SHD1_k127_2271731_4	686340.Metal_3938	1.955e-118	398.0	COG1028@1|root,COG1028@2|Bacteria,1MW9A@1224|Proteobacteria,1RMMZ@1236|Gammaproteobacteria,1XG2S@135618|Methylococcales	135618|Methylococcales	IQ	PFAM short chain dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
SHD1_k127_2271731_13	525904.Tter_0175	8.648e-31	131.0	COG0693@1|root,COG0693@2|Bacteria,2NPFP@2323|unclassified Bacteria	2|Bacteria	S	DJ-1/PfpI family	pfpI	-	3.5.1.124	ko:K05520	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DJ-1_PfpI
SHD1_k127_2271731_16	861299.J421_0091	1.69e-17	87.0	28XFN@1|root,2ZJD7@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2271731_12	1242864.D187_002986	6.108e-46	170.0	COG2050@1|root,COG2050@2|Bacteria,1RHAN@1224|Proteobacteria,43157@68525|delta/epsilon subdivisions,2WWIW@28221|Deltaproteobacteria,2YVGQ@29|Myxococcales	28221|Deltaproteobacteria	Q	Domain of unknown function (DUF4442)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4442
SHD1_k127_2271731_2	379066.GAU_1376	4.996e-131	434.0	COG2070@1|root,COG2070@2|Bacteria,1ZUN8@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Nitronate monooxygenase	-	-	1.13.12.16	ko:K00459	ko00910,map00910	-	R00025	RC02541,RC02759	ko00000,ko00001,ko01000	-	-	-	NMO
SHD1_k127_2271731_3	1192034.CAP_0902	7.218e-127	417.0	COG0026@1|root,COG0026@2|Bacteria,1MU70@1224|Proteobacteria,42PQI@68525|delta/epsilon subdivisions,2WKZR@28221|Deltaproteobacteria,2YUAG@29|Myxococcales	28221|Deltaproteobacteria	F	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)	purK	-	6.3.4.18	ko:K01589	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07404	RC01927	ko00000,ko00001,ko00002,ko01000	-	-	-	2-Hacid_dh_C,ATP-grasp
SHD1_k127_2271731_9	1144275.COCOR_05553	3.249e-66	232.0	COG0041@1|root,COG0041@2|Bacteria,1RCWJ@1224|Proteobacteria,42QTK@68525|delta/epsilon subdivisions,2WNXM@28221|Deltaproteobacteria,2YWCV@29|Myxococcales	28221|Deltaproteobacteria	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
SHD1_k127_2271731_0	861299.J421_0708	5.784e-174	554.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	ko:K08178	-	-	-	-	ko00000,ko02000	2.A.1.12	-	-	MFS_1,Sugar_tr
SHD1_k127_2271731_18	379066.GAU_0515	3.849e-08	66.0	COG4447@1|root,COG5492@1|root,COG4447@2|Bacteria,COG5492@2|Bacteria,1ZUDA@142182|Gemmatimonadetes	142182|Gemmatimonadetes	N	Bacterial Ig-like domain 2	-	-	-	-	-	-	-	-	-	-	-	-	Big_2
SHD1_k127_2298200_9	861299.J421_1299	0.000267	45.0	2FK3G@1|root,34BRK@2|Bacteria,1ZU1V@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Outer membrane protein beta-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl
SHD1_k127_2298200_5	379066.GAU_0162	2.548e-44	168.0	2CM4I@1|root,340QM@2|Bacteria,1ZTV4@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2298200_4	682795.AciX8_0601	1.184e-54	201.0	COG2095@1|root,COG2095@2|Bacteria,3Y429@57723|Acidobacteria,2JI6F@204432|Acidobacteriia	204432|Acidobacteriia	U	MarC family integral membrane protein	-	-	-	ko:K05595	-	-	-	-	ko00000,ko02000	2.A.95.1	-	-	MarC
SHD1_k127_2298200_6	861299.J421_2388	2.539e-30	128.0	COG0071@1|root,COG0071@2|Bacteria,1ZU6H@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	Hsp20/alpha crystallin family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
SHD1_k127_2298200_8	338963.Pcar_2312	3.244e-08	66.0	COG3829@1|root,COG4624@1|root,COG3829@2|Bacteria,COG4624@2|Bacteria,1R8T5@1224|Proteobacteria,42Q3W@68525|delta/epsilon subdivisions,2WK6C@28221|Deltaproteobacteria,43TPK@69541|Desulfuromonadales	28221|Deltaproteobacteria	K	Domains FehydlgC, FeS, sigma54 interaction, HTH8	-	-	-	-	-	-	-	-	-	-	-	-	FeS,Fe_hyd_lg_C,Fer4,HTH_8,Sigma54_activat
SHD1_k127_2298200_3	861299.J421_0519	3.141e-55	203.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	MA20_24885	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0008080,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0017076,GO:0030551,GO:0030552,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K07001,ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	Acetyltransf_3,cNMP_binding
SHD1_k127_2298200_1	861299.J421_1590	1.311e-70	249.0	COG0083@1|root,COG0083@2|Bacteria	2|Bacteria	E	homoserine kinase activity	thrB	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004413,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006555,GO:0006566,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009088,GO:0009092,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019202,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.1.39	ko:K00872	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	iECSE_1348.ECSE_0003,iJN678.thrB,iLJ478.TM0545,iSB619.SA_RS06620	GHMP_kinases_C,GHMP_kinases_N
SHD1_k127_2298200_2	861299.J421_0517	1.447e-60	221.0	COG1647@1|root,COG1647@2|Bacteria,1ZTVV@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Serine aminopeptidase, S33	-	-	3.1.1.1	ko:K03928	-	-	-	-	ko00000,ko01000	-	-	-	Hydrolase_4
SHD1_k127_2298200_7	1121104.AQXH01000001_gene2178	4.714e-25	116.0	2CDZB@1|root,3340J@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2298200_0	316274.Haur_1002	1.73e-103	350.0	COG1408@1|root,COG1408@2|Bacteria,2G6VC@200795|Chloroflexi,375MG@32061|Chloroflexia	200795|Chloroflexi	S	PFAM metallophosphoesterase	-	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos
SHD1_k127_2306358_5	278963.ATWD01000001_gene4693	3.473e-20	93.0	COG3411@1|root,COG3411@2|Bacteria,3Y54Q@57723|Acidobacteria,2JJSF@204432|Acidobacteriia	204432|Acidobacteriia	C	Ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2306358_4	861299.J421_1503	2.483e-41	158.0	COG2318@1|root,COG2318@2|Bacteria,1ZU0D@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
SHD1_k127_2306358_1	861299.J421_4484	1.887e-144	464.0	COG2897@1|root,COG2897@2|Bacteria,1ZTF6@142182|Gemmatimonadetes	142182|Gemmatimonadetes	P	Rhodanese Homology Domain	-	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
SHD1_k127_2306358_3	861299.J421_4485	3.512e-42	161.0	COG1765@1|root,COG1765@2|Bacteria,1ZTV1@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	OsmC-like protein	-	-	-	ko:K07397	-	-	-	-	ko00000	-	-	-	OsmC
SHD1_k127_2306358_0	861299.J421_1997	6.057e-160	507.0	COG0031@1|root,COG0031@2|Bacteria,1ZTHE@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Pyridoxal-phosphate dependent enzyme	-	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
SHD1_k127_2306358_2	926569.ANT_05100	1.126e-85	291.0	COG2326@1|root,COG2326@2|Bacteria,2G5UP@200795|Chloroflexi	200795|Chloroflexi	S	Polyphosphate kinase 2 (PPK2)	-	-	-	-	-	-	-	-	-	-	-	-	PPK2
SHD1_k127_2306358_6	861299.J421_0294	0.0007801	47.0	COG1725@1|root,COG1725@2|Bacteria	2|Bacteria	K	Transcriptional regulator	-	-	-	ko:K07979	-	-	-	-	ko00000,ko03000	-	-	-	GntR
SHD1_k127_231441_0	1379698.RBG1_1C00001G0607	5.593e-106	359.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2NQNE@2323|unclassified Bacteria	2|Bacteria	T	Serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase,TPR_2,TPR_8
SHD1_k127_231441_1	861299.J421_1230	1.731e-56	201.0	COG0515@1|root,COG0515@2|Bacteria	861299.J421_1230|-	KLT	protein kinase activity	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	-
SHD1_k127_2317927_2	1220589.CD32_13375	1.827e-07	59.0	2AVBG@1|root,31M2S@2|Bacteria,1VV6J@1239|Firmicutes,4HVNA@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2317927_3	392499.Swit_4049	2.514e-05	51.0	28ZXZ@1|root,2ZMNF@2|Bacteria,1NM5Z@1224|Proteobacteria,2UWBC@28211|Alphaproteobacteria,2K81I@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2317927_0	861299.J421_2050	9.53e-30	129.0	COG3695@1|root,COG3695@2|Bacteria	2|Bacteria	L	enzyme binding	ogt	-	2.1.1.63	ko:K00567,ko:K07443	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1,YjbR
SHD1_k127_2317927_1	1237149.C900_04034	6.85e-29	121.0	COG2329@1|root,COG2329@2|Bacteria,4NUCI@976|Bacteroidetes	976|Bacteroidetes	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2319471_7	869213.JCM21142_96	1.134e-77	275.0	COG2235@1|root,COG2235@2|Bacteria,4NHKZ@976|Bacteroidetes,47JM7@768503|Cytophagia	976|Bacteroidetes	E	Arginine deiminase	-	-	3.5.3.6	ko:K01478	ko00220,ko01100,ko01110,ko01130,map00220,map01100,map01110,map01130	-	R00552	RC00177	ko00000,ko00001,ko01000	-	-	-	Amidinotransf
SHD1_k127_2319471_5	861299.J421_3450	7.151e-87	299.0	COG0847@1|root,COG0847@2|Bacteria,1ZTNH@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	EXOIII	-	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
SHD1_k127_2319471_2	861299.J421_3449	1.917e-131	441.0	COG0491@1|root,COG0491@2|Bacteria,1ZT7V@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
SHD1_k127_2319471_6	379066.GAU_1878	7.589e-82	277.0	COG0290@1|root,COG0290@2|Bacteria,1ZTM6@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	-	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
SHD1_k127_2319471_11	1379270.AUXF01000006_gene83	3.827e-20	91.0	COG0291@1|root,COG0291@2|Bacteria,1ZU3P@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Ribosomal protein L35	rpmI	-	-	ko:K02916	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35p
SHD1_k127_2319471_8	1379270.AUXF01000006_gene84	2.904e-52	187.0	COG0292@1|root,COG0292@2|Bacteria,1ZTUF@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	-	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
SHD1_k127_2319471_3	861299.J421_3445	9.181e-124	405.0	COG0016@1|root,COG0016@2|Bacteria,1ZSQR@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Aminoacyl tRNA synthetase class II, N-terminal domain	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
SHD1_k127_2319471_1	1379270.AUXF01000006_gene86	1.688e-234	756.0	COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,1ZSWJ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	B3/4 domain	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
SHD1_k127_2319471_10	1379270.AUXF01000006_gene88	2.551e-24	106.0	COG3027@1|root,COG3027@2|Bacteria,1ZU4G@142182|Gemmatimonadetes	142182|Gemmatimonadetes	D	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division	-	-	-	ko:K09888	-	-	-	-	ko00000,ko03036	-	-	-	ZapA
SHD1_k127_2319471_0	861299.J421_3441	1.463e-234	735.0	COG1418@1|root,COG1418@2|Bacteria,1ZT0I@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Endoribonuclease that initiates mRNA decay	rny	-	-	ko:K18682	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DUF3552,HD,KH_1
SHD1_k127_2319471_4	1379270.AUXF01000006_gene90	2.248e-112	370.0	COG0190@1|root,COG0190@2|Bacteria,1ZSVX@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	-	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
SHD1_k127_2319471_9	861299.J421_3439	5.414e-44	166.0	COG1570@1|root,COG1570@2|Bacteria,1ZT8T@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
SHD1_k127_2334732_0	1379270.AUXF01000002_gene1583	6.166e-56	217.0	COG0515@1|root,COG0515@2|Bacteria	1379270.AUXF01000002_gene1583|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2341308_0	861299.J421_6339	4.431e-271	845.0	COG3507@1|root,COG3507@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 43 family	-	-	-	-	-	-	-	-	-	-	-	-	F5_F8_type_C,Glyco_hydro_43
SHD1_k127_2341308_1	272558.10174569	3.278e-96	326.0	COG1063@1|root,COG1063@2|Bacteria,1UY29@1239|Firmicutes,4HE5C@91061|Bacilli,1ZDDR@1386|Bacillus	91061|Bacilli	E	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
SHD1_k127_2345989_3	861299.J421_1852	1.79e-87	295.0	COG2207@1|root,COG2207@2|Bacteria,1ZV3U@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	helix_turn_helix, arabinose operon control protein	-	-	-	ko:K07506	-	-	-	-	ko00000,ko03000	-	-	-	AraC_binding,HTH_18
SHD1_k127_2345989_6	861299.J421_1850	1.903e-39	153.0	2CN2H@1|root,32SG5@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2345989_2	861299.J421_1851	6.377e-93	311.0	COG0693@1|root,COG0693@2|Bacteria	2|Bacteria	S	protein deglycation	thiJ	-	4.2.1.103	ko:K18199	ko00930,map00930	-	R05771	RC01467	ko00000,ko00001,ko01000,ko01002	-	-	-	DJ-1_PfpI
SHD1_k127_2345989_4	405948.SACE_6341	1.728e-68	240.0	COG0262@1|root,COG0262@2|Bacteria,2GKX0@201174|Actinobacteria,4E4E5@85010|Pseudonocardiales	201174|Actinobacteria	H	Dihydrofolate reductase	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
SHD1_k127_2345989_0	426114.THI_1134	1.235e-222	700.0	COG0433@1|root,COG0433@2|Bacteria,1MU59@1224|Proteobacteria,2VIJY@28216|Betaproteobacteria,1KJ6Y@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Bacterial protein of unknown function (DUF853)	yjgR	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF853
SHD1_k127_2345989_7	861299.J421_3050	2.972e-35	141.0	COG0597@1|root,COG0597@2|Bacteria,1ZTWA@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	-	-	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
SHD1_k127_2345989_8	861299.J421_1473	1.731e-29	122.0	COG3603@1|root,COG3603@2|Bacteria	2|Bacteria	S	ACT domain	-	-	-	ko:K09707	-	-	-	-	ko00000	-	-	-	ACT_7
SHD1_k127_2345989_1	861299.J421_4298	3.671e-175	569.0	COG2132@1|root,COG2132@2|Bacteria,1ZUD9@142182|Gemmatimonadetes	142182|Gemmatimonadetes	Q	Multicopper oxidase	-	-	1.16.3.3	ko:K22348	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_2,Cu-oxidase_3
SHD1_k127_2345989_5	861299.J421_1729	1.832e-50	191.0	COG0515@1|root,COG0515@2|Bacteria,1ZUCF@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
SHD1_k127_2353016_0	861299.J421_3896	5.136e-196	617.0	COG0626@1|root,COG0626@2|Bacteria,1ZT9F@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Cys/Met metabolism PLP-dependent enzyme	-	-	4.4.1.1	ko:K01758	ko00260,ko00270,ko00450,ko01100,ko01130,ko01230,map00260,map00270,map00450,map01100,map01130,map01230	M00338	R00782,R01001,R02408,R04770,R04930,R09366	RC00056,RC00069,RC00348,RC00382,RC00710,RC01209,RC01210,RC01245,RC02303	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Cys_Met_Meta_PP
SHD1_k127_2353016_5	1379270.AUXF01000003_gene3494	1.372e-113	379.0	COG0501@1|root,COG0501@2|Bacteria,1ZT2E@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
SHD1_k127_2353016_3	1128421.JAGA01000002_gene1070	7.694e-122	407.0	COG0151@1|root,COG0151@2|Bacteria,2NP0B@2323|unclassified Bacteria	2|Bacteria	F	Belongs to the GARS family	purD	-	6.3.3.1,6.3.4.13	ko:K01945,ko:K11788	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144,R04208	RC00090,RC00166,RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
SHD1_k127_2353016_6	1379270.AUXF01000003_gene3492	1.378e-92	316.0	COG0266@1|root,COG0266@2|Bacteria,1ZU9K@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	-	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
SHD1_k127_2353016_2	861299.J421_3900	1.127e-126	422.0	COG0322@1|root,COG0322@2|Bacteria,1ZSVG@142182|Gemmatimonadetes	2|Bacteria	L	GIY-YIG type nucleases (URI domain)	-	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,UVR
SHD1_k127_2353016_8	861299.J421_3903	9.719e-55	199.0	COG0622@1|root,COG0622@2|Bacteria,1ZTSV@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	ko:K07095	-	-	-	-	ko00000	-	-	-	Metallophos_2
SHD1_k127_2353016_7	861299.J421_3904	3.702e-83	291.0	COG0163@1|root,COG0163@2|Bacteria,1ZTIK@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN	ubiX	-	2.5.1.129	ko:K03186	ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220	M00117	R01238,R02952,R03367,R04985,R04986,R11225	RC00391,RC00814,RC03392	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavoprotein
SHD1_k127_2353016_4	861299.J421_3905	7.863e-115	381.0	COG0382@1|root,COG0382@2|Bacteria,1ZT35@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	UbiA prenyltransferase family	-	-	2.5.1.39	ko:K03179	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R05000,R05615	RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
SHD1_k127_2353016_1	861299.J421_3906	4.232e-152	482.0	COG0043@1|root,COG0043@2|Bacteria,1ZSMS@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	3-octaprenyl-4-hydroxybenzoate carboxy-lyase	-	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
SHD1_k127_2365708_4	1379270.AUXF01000004_gene2978	2.341e-36	158.0	COG0803@1|root,COG0803@2|Bacteria,1ZSS4@142182|Gemmatimonadetes	142182|Gemmatimonadetes	P	Belongs to the bacterial solute-binding protein 9 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF4175
SHD1_k127_2365708_2	861299.J421_0523	1.288e-72	267.0	2FFKA@1|root,347HR@2|Bacteria,1ZU3F@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2365708_3	861299.J421_0522	4.126e-69	244.0	COG1721@1|root,COG1721@2|Bacteria,1ZTP6@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
SHD1_k127_2365708_1	861299.J421_0520	6.032e-141	455.0	COG0714@1|root,COG0714@2|Bacteria,1ZT4A@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
SHD1_k127_2365708_0	1128421.JAGA01000002_gene335	6.84e-143	470.0	COG2124@1|root,COG2124@2|Bacteria	2|Bacteria	Q	cytochrome p450	-	-	-	-	-	-	-	-	-	-	-	-	p450
SHD1_k127_2366816_5	861299.J421_3251	1.009e-20	98.0	COG1137@1|root,COG1137@2|Bacteria,1ZT4S@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	ABC transporter	-	-	-	ko:K06861	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	1.B.42.1	-	-	ABC_tran
SHD1_k127_2366816_3	861299.J421_3252	2.502e-94	328.0	2F01D@1|root,33T57@2|Bacteria,1ZTGK@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2366816_2	861299.J421_3254	1.134e-113	380.0	COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,1ZT08@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	SIS domain	-	-	5.3.1.13	ko:K06041	ko00540,ko01100,map00540,map01100	M00063	R01530	RC00541	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CBS,SIS
SHD1_k127_2366816_4	861299.J421_3255	3.402e-58	216.0	COG1778@1|root,COG1778@2|Bacteria,1ZTTG@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	haloacid dehalogenase-like hydrolase	-	-	3.1.3.45	ko:K03270	ko00540,ko01100,map00540,map01100	M00063	R03350	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hydrolase_3
SHD1_k127_2366816_1	1379270.AUXF01000006_gene266	9.796e-118	384.0	COG2877@1|root,COG2877@2|Bacteria,1ZUCD@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	DAHP synthetase I family	-	-	2.5.1.55	ko:K01627	ko00540,ko01100,map00540,map01100	M00063	R03254	RC00435	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	DAHP_synth_1
SHD1_k127_2366816_0	861299.J421_3257	9.091e-285	882.0	COG0504@1|root,COG0504@2|Bacteria,1ZT0J@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
SHD1_k127_2388356_1	861299.J421_2943	1.659e-56	201.0	COG1234@1|root,COG1234@2|Bacteria,1ZT5E@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
SHD1_k127_2388356_0	861299.J421_2945	4.569e-163	526.0	COG1196@1|root,COG1196@2|Bacteria,1ZSY1@142182|Gemmatimonadetes	142182|Gemmatimonadetes	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
SHD1_k127_2394283_0	1379270.AUXF01000005_gene826	2.065e-187	599.0	COG0342@1|root,COG0342@2|Bacteria,1ZTBW@142182|Gemmatimonadetes	142182|Gemmatimonadetes	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
SHD1_k127_2397135_0	861299.J421_3341	4.767e-233	737.0	COG0514@1|root,COG0514@2|Bacteria,1ZSNS@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	RecQ zinc-binding	-	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecQ_Zn_bind
SHD1_k127_2409828_5	1499968.TCA2_3606	4.558e-19	94.0	COG0438@1|root,COG0438@2|Bacteria,1VDFZ@1239|Firmicutes,4HCGX@91061|Bacilli,26U6B@186822|Paenibacillaceae	91061|Bacilli	M	Glycosyl transferase	-	-	2.4.1.346	ko:K13668	-	-	R11703,R11704	-	ko00000,ko01000,ko01003	-	GT4	-	Glyco_transf_4,Glycos_transf_1
SHD1_k127_2409828_0	1244869.H261_14005	5.325e-185	598.0	COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,2TSCY@28211|Alphaproteobacteria,2JW1S@204441|Rhodospirillales	204441|Rhodospirillales	E	Asparagine synthase	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
SHD1_k127_2409828_2	309807.SRU_0620	2.361e-101	346.0	COG0438@1|root,COG0438@2|Bacteria,4NKNS@976|Bacteroidetes,1FK33@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
SHD1_k127_2409828_1	1128421.JAGA01000003_gene3206	1.896e-127	431.0	COG0381@1|root,COG0381@2|Bacteria,2NNVT@2323|unclassified Bacteria	2|Bacteria	M	UDP-N-acetylglucosamine 2-epimerase	wecB	-	5.1.3.14	ko:K01791	ko00520,ko01100,ko05111,map00520,map01100,map05111	M00362	R00420	RC00290	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase_2
SHD1_k127_2409828_3	1033737.CAEV01000041_gene1513	2.258e-64	240.0	COG0472@1|root,COG0472@2|Bacteria,1TP9V@1239|Firmicutes,247M7@186801|Clostridia,36F6R@31979|Clostridiaceae	186801|Clostridia	M	PFAM Glycosyl transferase family 4	tagO	-	2.7.8.33,2.7.8.35	ko:K02851	-	-	R08856	RC00002	ko00000,ko01000,ko01003,ko01005	-	-	-	Glycos_transf_4
SHD1_k127_2409828_7	1230476.C207_01247	7.623e-08	61.0	COG0250@1|root,COG0250@2|Bacteria,1N01W@1224|Proteobacteria,2U697@28211|Alphaproteobacteria,3JY91@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	In Spt5p, this domain may confer affinity for Spt4p. It possesses a RNP-like fold.	-	-	-	ko:K05785	-	-	-	-	ko00000,ko03000	-	-	-	NusG
SHD1_k127_2409828_6	1123247.AUIJ01000001_gene1724	3.75e-11	75.0	COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,2TR03@28211|Alphaproteobacteria	28211|Alphaproteobacteria	U	Involved in the TonB-independent uptake of proteins	tolB	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40,TolB_N
SHD1_k127_2409828_8	1279038.KB907338_gene745	2.143e-06	58.0	COG1493@1|root,COG1493@2|Bacteria,1RE0J@1224|Proteobacteria,2U8MR@28211|Alphaproteobacteria,2JTCE@204441|Rhodospirillales	204441|Rhodospirillales	T	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2409828_4	56107.Cylst_2352	6.052e-26	109.0	COG0665@1|root,COG0723@1|root,COG0665@2|Bacteria,COG0723@2|Bacteria,1G0WY@1117|Cyanobacteria,1HMIN@1161|Nostocales	1117|Cyanobacteria	CE	Glycine D-amino acid oxidase (deaminating)	-	-	-	-	-	-	-	-	-	-	-	-	DAO,Rieske
SHD1_k127_2422351_0	1123508.JH636439_gene1510	8.124e-178	575.0	COG0463@1|root,COG0726@1|root,COG0463@2|Bacteria,COG0726@2|Bacteria,2IWT2@203682|Planctomycetes	203682|Planctomycetes	G	Domain of unknown function (DUF3473)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3473,Glycos_transf_2,Polysacc_deac_1
SHD1_k127_2422351_1	1095769.CAHF01000011_gene2006	3.122e-83	287.0	COG0382@1|root,COG0382@2|Bacteria,1MXCM@1224|Proteobacteria,2VKY4@28216|Betaproteobacteria,4751T@75682|Oxalobacteraceae	28216|Betaproteobacteria	EH	UbiA prenyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	HAD,UbiA
SHD1_k127_2438788_0	1379270.AUXF01000001_gene2615	0.0	1321.0	COG0587@1|root,COG0587@2|Bacteria,1ZU9R@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	Helix-hairpin-helix motif	-	-	2.7.7.7	ko:K14162	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
SHD1_k127_2438788_1	1379270.AUXF01000001_gene2628	2.568e-120	408.0	COG0389@1|root,COG0389@2|Bacteria,1ZUEI@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	-	-	-	ko:K14161	-	-	-	-	ko00000,ko03400	-	-	-	-
SHD1_k127_2438788_3	379066.GAU_2731	1.809e-40	162.0	COG0468@1|root,COG0468@2|Bacteria,1ZUMI@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	Rad51	-	-	-	-	-	-	-	-	-	-	-	-	RecA
SHD1_k127_2438788_2	1340493.JNIF01000004_gene83	1.331e-67	233.0	COG2513@1|root,COG2513@2|Bacteria	2|Bacteria	G	methylisocitrate lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	PEP_mutase
SHD1_k127_2440611_3	379066.GAU_2161	1.894e-52	192.0	COG2177@1|root,COG2177@2|Bacteria,1ZTDR@142182|Gemmatimonadetes	142182|Gemmatimonadetes	D	Part of the ABC transporter FtsEX involved in	-	-	-	ko:K09811	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	-
SHD1_k127_2440611_2	861299.J421_3759	1.643e-88	299.0	COG2884@1|root,COG2884@2|Bacteria,1ZTHQ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	D	ABC transporter	-	-	-	ko:K09812	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	ABC_tran
SHD1_k127_2440611_6	861299.J421_3757	4.098e-22	103.0	298RJ@1|root,2ZVVV@2|Bacteria,1ZU7B@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Molydop_binding
SHD1_k127_2440611_4	861299.J421_3756	1.359e-47	188.0	2EFCU@1|root,3395Q@2|Bacteria,1ZTVZ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2440611_1	861299.J421_3755	3.301e-129	421.0	COG0643@1|root,COG0643@2|Bacteria,1ZSPB@142182|Gemmatimonadetes	142182|Gemmatimonadetes	NT	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2440611_0	379066.GAU_2155	3.359e-130	424.0	COG0524@1|root,COG0524@2|Bacteria,1ZTFD@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2440611_5	861299.J421_3753	1.103e-42	159.0	COG1940@1|root,COG1940@2|Bacteria,1ZT66@142182|Gemmatimonadetes	142182|Gemmatimonadetes	GK	ROK family	-	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
SHD1_k127_2445064_4	1173028.ANKO01000112_gene4886	3.665e-49	184.0	COG1091@1|root,COG2723@1|root,COG1091@2|Bacteria,COG2723@2|Bacteria,1G1JP@1117|Cyanobacteria,1HES1@1150|Oscillatoriales	1117|Cyanobacteria	GM	Glycosyl hydrolase family 1	-	-	1.1.1.133	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_1,RmlD_sub_bind
SHD1_k127_2445064_0	402777.KB235898_gene5159	4.124e-182	590.0	COG0562@1|root,COG0562@2|Bacteria,1G3KR@1117|Cyanobacteria,1HA1P@1150|Oscillatoriales	1117|Cyanobacteria	M	PFAM UDP-galactopyranose mutase, C-terminal	-	-	5.4.99.9	ko:K01854	ko00052,ko00520,map00052,map00520	-	R00505,R09009	RC00317,RC02396	ko00000,ko00001,ko01000	-	-	-	GLF,Glyco_trans_1_4,NAD_binding_8
SHD1_k127_2445064_1	1242864.D187_001873	5.015e-141	459.0	COG0438@1|root,COG0438@2|Bacteria,1QU2N@1224|Proteobacteria,42PY5@68525|delta/epsilon subdivisions,2WIU8@28221|Deltaproteobacteria,2YVJ5@29|Myxococcales	28221|Deltaproteobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4
SHD1_k127_2445064_3	1134912.AJTV01000021_gene3005	1.829e-59	221.0	COG0153@1|root,COG0153@2|Bacteria,1MVQD@1224|Proteobacteria,2U2RP@28211|Alphaproteobacteria,36ZV4@31993|Methylocystaceae	28211|Alphaproteobacteria	G	Galactokinase galactose-binding signature	galK	-	2.7.1.6	ko:K00849	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00554,M00632	R01092	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg
SHD1_k127_2445064_2	1335760.ASTG01000016_gene161	3.027e-123	407.0	COG2723@1|root,COG2723@2|Bacteria,1MWU7@1224|Proteobacteria,2TT4I@28211|Alphaproteobacteria,2K354@204457|Sphingomonadales	204457|Sphingomonadales	G	Glycosyl hydrolase family 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_1
SHD1_k127_2450059_1	240015.ACP_0152	2.552e-39	151.0	COG2318@1|root,COG2318@2|Bacteria,3Y5DP@57723|Acidobacteria,2JN3K@204432|Acidobacteriia	204432|Acidobacteriia	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
SHD1_k127_2450059_2	471854.Dfer_2157	1.542e-05	50.0	297EW@1|root,2ZUNA@2|Bacteria,4P6WI@976|Bacteroidetes,47WJA@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2450059_0	861299.J421_6356	1.032e-206	659.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
SHD1_k127_2459720_2	1121472.AQWN01000015_gene1359	3.303e-16	78.0	COG0050@1|root,COG0050@2|Bacteria,1TPKC@1239|Firmicutes,2485I@186801|Clostridia,2602U@186807|Peptococcaceae	186801|Clostridia	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
SHD1_k127_2459720_4	1121875.KB907554_gene506	0.0002677	44.0	2EHBZ@1|root,33B3U@2|Bacteria,4NZK3@976|Bacteroidetes,1I71Q@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2459720_0	861299.J421_2757	2.652e-219	689.0	COG0215@1|root,COG0215@2|Bacteria,1ZT77@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	DALR_2	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e
SHD1_k127_2459720_1	379066.GAU_3353	1.543e-20	94.0	2F75B@1|root,33ZKU@2|Bacteria,1ZTZQ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2459720_3	652103.Rpdx1_4996	3.846e-07	60.0	COG1136@1|root,COG1136@2|Bacteria,1NCFC@1224|Proteobacteria,2TSNF@28211|Alphaproteobacteria,3JV6H@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	V	ABC transporter	MA20_22875	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SHD1_k127_2461871_0	518766.Rmar_0536	1.847e-222	713.0	COG1472@1|root,COG1472@2|Bacteria,4NE90@976|Bacteroidetes,1FIS9@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	G	PFAM glycoside hydrolase family 3 domain protein	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
SHD1_k127_2461871_1	639030.JHVA01000001_gene2685	9.578e-37	141.0	COG1695@1|root,COG1695@2|Bacteria,3Y4XM@57723|Acidobacteria,2JJHR@204432|Acidobacteriia	204432|Acidobacteriia	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
SHD1_k127_2461871_2	401053.AciPR4_1273	2.645e-19	96.0	COG0577@1|root,COG0577@2|Bacteria,3Y6C8@57723|Acidobacteria,2JMHC@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
SHD1_k127_2462639_7	1267534.KB906756_gene712	1.573e-46	177.0	2A3BS@1|root,30RTX@2|Bacteria,3Y943@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2462639_9	414684.RC1_1599	2.275e-29	121.0	COG2261@1|root,COG2261@2|Bacteria,1N72W@1224|Proteobacteria,2UBU4@28211|Alphaproteobacteria,2JTUG@204441|Rhodospirillales	204441|Rhodospirillales	S	Transglycosylase associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
SHD1_k127_2462639_1	861299.J421_1725	1.582e-87	310.0	COG0642@1|root,COG2205@2|Bacteria	861299.J421_1725|-	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2462639_2	42565.FP66_13215	7.722e-71	246.0	COG2085@1|root,COG2085@2|Bacteria,1MV62@1224|Proteobacteria,1RY91@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	NADP oxidoreductase coenzyme F420-dependent	-	-	1.5.1.40	ko:K06988	-	-	-	-	ko00000,ko01000	-	-	-	F420_oxidored
SHD1_k127_2462639_5	1454007.JAUG01000073_gene4096	6.003e-56	201.0	COG1335@1|root,COG1335@2|Bacteria	2|Bacteria	Q	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	-	-	3.5.1.19	ko:K08281	ko00760,ko01100,map00760,map01100	-	R01268	RC00100	ko00000,ko00001,ko01000	-	-	-	Isochorismatase
SHD1_k127_2462639_8	926554.KI912671_gene128	1.58e-30	132.0	COG0583@1|root,COG0583@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
SHD1_k127_2462639_11	644282.Deba_3082	1.384e-11	76.0	COG0392@1|root,COG0392@2|Bacteria	2|Bacteria	M	lysyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	LPG_synthase_TM
SHD1_k127_2462639_4	479434.Sthe_0858	2.174e-61	224.0	COG0500@1|root,COG2226@2|Bacteria,2G8WR@200795|Chloroflexi,27YA7@189775|Thermomicrobia	189775|Thermomicrobia	Q	Protein of unknown function (DUF1698)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
SHD1_k127_2462639_6	861299.J421_1513	1.466e-53	198.0	2CWY1@1|root,32T0M@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2462639_3	768671.ThimaDRAFT_1778	4.122e-68	243.0	COG2515@1|root,COG2515@2|Bacteria,1MVYF@1224|Proteobacteria,1RMYP@1236|Gammaproteobacteria,1X0CX@135613|Chromatiales	135613|Chromatiales	E	Pyridoxal-phosphate dependent enzyme	-	-	4.4.1.25	ko:K17950	ko00270,map00270	-	R07634	RC01784	ko00000,ko00001,ko01000	-	-	-	PALP
SHD1_k127_2462639_0	861299.J421_4169	3.388e-193	611.0	COG0531@1|root,COG0531@2|Bacteria,1ZSQW@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Amino acid permease	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
SHD1_k127_2462639_10	1242864.D187_006458	6.312e-12	75.0	COG0457@1|root,COG0457@2|Bacteria,1PYTB@1224|Proteobacteria,42VYS@68525|delta/epsilon subdivisions	1224|Proteobacteria	S	Tetratricopeptide repeat	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	TPR_16,TPR_2,TPR_6,TPR_8
SHD1_k127_2465233_1	861299.J421_0475	6.908e-67	233.0	COG1595@1|root,COG1595@2|Bacteria,1ZUZ9@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
SHD1_k127_2465233_0	861299.J421_0476	3.284e-306	966.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,1ZTK4@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Tetratricopeptide repeat	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_12
SHD1_k127_2465800_3	1123508.JH636452_gene6965	8.231e-40	156.0	COG0640@1|root,COG0640@2|Bacteria,2IZUJ@203682|Planctomycetes	203682|Planctomycetes	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5
SHD1_k127_2465800_1	1449069.JMLO01000019_gene2837	8.118e-46	168.0	COG0346@1|root,COG0346@2|Bacteria,2IKTR@201174|Actinobacteria,4G18K@85025|Nocardiaceae	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
SHD1_k127_2465800_2	1502851.FG93_03978	1.61e-43	164.0	COG3832@1|root,COG3832@2|Bacteria,1MZXG@1224|Proteobacteria,2UBQP@28211|Alphaproteobacteria,3K6AW@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
SHD1_k127_2465800_0	1379270.AUXF01000001_gene2066	4.986e-49	188.0	COG2206@1|root,COG2206@2|Bacteria	2|Bacteria	T	PFAM metal-dependent phosphohydrolase, HD sub domain	-	-	-	-	-	-	-	-	-	-	-	-	HD
SHD1_k127_249044_4	748247.AZKH_2012	3.734e-118	397.0	COG3712@1|root,COG3712@2|Bacteria,1N941@1224|Proteobacteria,2VIKR@28216|Betaproteobacteria,2KVI1@206389|Rhodocyclales	28216|Betaproteobacteria	PT	iron ion homeostasis	-	-	-	-	-	-	-	-	-	-	-	-	FecR
SHD1_k127_249044_8	861299.J421_0998	7.049e-59	209.0	COG0494@1|root,COG0494@2|Bacteria	2|Bacteria	L	nUDIX hydrolase	mutT3	-	3.6.1.13,3.6.1.55,3.6.1.67	ko:K01515,ko:K03574,ko:K08310	ko00230,ko00790,map00230,map00790	M00126	R01054,R04638	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	NUDIX
SHD1_k127_249044_3	861299.J421_2550	1.547e-124	404.0	COG0266@1|root,COG0266@2|Bacteria,1ZUR3@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	Formamidopyrimidine-DNA glycosylase N-terminal domain	-	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
SHD1_k127_249044_11	69395.JQLZ01000006_gene2299	1.092e-24	120.0	2E32R@1|root,32Y2Y@2|Bacteria,1N91I@1224|Proteobacteria,2UI6P@28211|Alphaproteobacteria,2KJD1@204458|Caulobacterales	204458|Caulobacterales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_249044_9	330214.NIDE4014	1.655e-57	216.0	2EUIU@1|root,33N0V@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_249044_6	215803.DB30_3730	3.39e-78	270.0	COG2819@1|root,COG2819@2|Bacteria,1N4R1@1224|Proteobacteria,43BZF@68525|delta/epsilon subdivisions,2X7A6@28221|Deltaproteobacteria,2YXXF@29|Myxococcales	28221|Deltaproteobacteria	S	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	CBM_20,Esterase
SHD1_k127_249044_5	926550.CLDAP_22650	1.073e-97	336.0	COG4947@1|root,COG4947@2|Bacteria	2|Bacteria	P	esterase	XK27_05675	-	-	-	-	-	-	-	-	-	-	-	Esterase
SHD1_k127_249044_2	1210884.HG799465_gene12056	3.415e-144	463.0	COG0189@1|root,COG0189@2|Bacteria	2|Bacteria	HJ	Glutathione synthase Ribosomal protein S6 modification enzyme (Glutaminyl transferase)	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_249044_1	379066.GAU_1360	4.245e-159	526.0	COG2308@1|root,COG2308@2|Bacteria,1ZT4M@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	CP_ATPgrasp_2
SHD1_k127_249044_0	379066.GAU_1362	1.967e-173	552.0	COG2170@1|root,COG2170@2|Bacteria,1ZTBN@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity	-	-	-	ko:K06048	-	-	-	-	ko00000,ko01000	-	-	-	GCS2
SHD1_k127_249044_7	1210884.HG799464_gene10702	8.166e-77	266.0	COG2071@1|root,COG2071@2|Bacteria,2J32U@203682|Planctomycetes	203682|Planctomycetes	S	Peptidase C26	-	-	-	ko:K07010	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_C26
SHD1_k127_249044_10	1469607.KK073768_gene4678	1.37e-28	126.0	COG1216@1|root,COG1216@2|Bacteria,1G3JX@1117|Cyanobacteria	1117|Cyanobacteria	M	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
SHD1_k127_2495981_1	1384049.CD29_10945	2e-169	542.0	COG0481@1|root,COG0481@2|Bacteria,1TP0G@1239|Firmicutes,4HASA@91061|Bacilli,3IX78@400634|Lysinibacillus	91061|Bacilli	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2,LepA_C
SHD1_k127_2495981_3	861299.J421_3749	1.261e-119	391.0	COG1721@1|root,COG1721@2|Bacteria,1ZT0H@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
SHD1_k127_2495981_2	861299.J421_3748	1.195e-155	513.0	COG1572@1|root,COG1572@2|Bacteria	2|Bacteria	NU	bacterial-type flagellum-dependent cell motility	-	-	3.4.21.10	ko:K01317	-	-	-	-	ko00000,ko01000,ko01002,ko04131	-	-	-	BatA,CARDB,F5_F8_type_C,HemolysinCabind,Laminin_G_3,NIDO,VWA_2
SHD1_k127_2495981_0	379066.GAU_2148	9.024e-183	583.0	COG1197@1|root,COG1197@2|Bacteria,1ZT88@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
SHD1_k127_249692_1	861299.J421_1941	2.981e-231	733.0	COG2217@1|root,COG2217@2|Bacteria,1ZTC7@142182|Gemmatimonadetes	142182|Gemmatimonadetes	P	E1-E2 ATPase	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
SHD1_k127_249692_5	1267535.KB906767_gene1078	1.179e-11	68.0	COG2608@1|root,COG2608@2|Bacteria	2|Bacteria	P	mercury ion transmembrane transporter activity	-	-	-	ko:K07213	ko04978,map04978	-	-	-	ko00000,ko00001	-	-	-	HMA
SHD1_k127_249692_4	1173024.KI912148_gene4396	2.574e-41	164.0	COG2267@1|root,COG2267@2|Bacteria,1GQJU@1117|Cyanobacteria	1117|Cyanobacteria	I	Ndr family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
SHD1_k127_249692_2	861299.J421_3854	2.788e-158	509.0	COG0544@1|root,COG0544@2|Bacteria,1ZSSF@142182|Gemmatimonadetes	142182|Gemmatimonadetes	D	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	-	-	ko:K03545	-	-	-	-	ko00000	-	-	-	Trigger_C,Trigger_N
SHD1_k127_249692_3	404589.Anae109_3421	3.073e-81	275.0	COG0740@1|root,COG0740@2|Bacteria,1MV46@1224|Proteobacteria,42MFU@68525|delta/epsilon subdivisions,2WK74@28221|Deltaproteobacteria,2YUR2@29|Myxococcales	28221|Deltaproteobacteria	O	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
SHD1_k127_249692_0	861299.J421_3856	6.528e-232	722.0	COG1219@1|root,COG1219@2|Bacteria,1ZT8F@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	-	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
SHD1_k127_2519110_0	861299.J421_2042	8.316e-245	767.0	COG0308@1|root,COG0308@2|Bacteria,1ZU50@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Peptidase family M1 domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1
SHD1_k127_2519110_2	204669.Acid345_1594	3.284e-23	108.0	COG0457@1|root,COG0457@2|Bacteria,3Y4VN@57723|Acidobacteria,2JJG5@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein of unknown function (DUF2911)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2911
SHD1_k127_2519110_1	861299.J421_3811	5.439e-58	212.0	COG1640@1|root,COG1640@2|Bacteria,1ZU23@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	4-alpha-glucanotransferase	-	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
SHD1_k127_2520745_0	861299.J421_2948	1.615e-186	593.0	COG0823@1|root,COG4775@1|root,COG0823@2|Bacteria,COG4775@2|Bacteria,1ZSUS@142182|Gemmatimonadetes	142182|Gemmatimonadetes	MU	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	Bac_surface_Ag,PD40
SHD1_k127_2520745_5	861299.J421_2949	1.039e-40	156.0	COG0799@1|root,COG0799@2|Bacteria,1ZU0S@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation	rsfS	-	-	ko:K09710	-	-	-	-	ko00000,ko03009	-	-	-	RsfS
SHD1_k127_2520745_2	861299.J421_2950	2.567e-61	217.0	COG0359@1|root,COG0359@2|Bacteria,1ZTNG@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Binds to the 23S rRNA	rplI	-	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
SHD1_k127_2520745_3	861299.J421_2951	9.85e-57	212.0	2F1RZ@1|root,33US3@2|Bacteria,1ZUSC@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2232
SHD1_k127_2520745_7	379066.GAU_1205	1.452e-26	110.0	COG0238@1|root,COG0238@2|Bacteria,1ZU47@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit	rpsR	-	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
SHD1_k127_2520745_6	1379270.AUXF01000005_gene514	2.136e-36	154.0	COG0360@1|root,COG0360@2|Bacteria,1ZTYY@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Binds together with S18 to 16S ribosomal RNA	rpsF	-	-	ko:K02990	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S6
SHD1_k127_2520745_1	1541065.JRFE01000012_gene2480	8.767e-76	265.0	COG0503@1|root,COG0503@2|Bacteria	2|Bacteria	F	purine ribonucleoside salvage	apt	-	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
SHD1_k127_2520745_4	1449350.OCH239_17370	2.341e-44	181.0	COG1807@1|root,COG1807@2|Bacteria,1N693@1224|Proteobacteria,2UEDM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2520745_8	1076550.LH22_11330	2.026e-07	59.0	COG3103@1|root,COG3103@2|Bacteria,1PYEG@1224|Proteobacteria,1RSS0@1236|Gammaproteobacteria,3W2IB@53335|Pantoea	1236|Gammaproteobacteria	T	Protein of unknown function (DUF3761)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3761
SHD1_k127_252370_3	1380347.JNII01000006_gene1846	1.525e-25	110.0	COG1999@1|root,COG1999@2|Bacteria,2GKF0@201174|Actinobacteria,4EVKF@85013|Frankiales	201174|Actinobacteria	S	SCO1 SenC	-	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	SCO1-SenC
SHD1_k127_252370_1	251229.Chro_4925	7.113e-54	205.0	COG0664@1|root,COG0664@2|Bacteria,1G1UQ@1117|Cyanobacteria,3VJMP@52604|Pleurocapsales	1117|Cyanobacteria	K	COGs COG0664 cAMP-binding protein - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2
SHD1_k127_252370_4	479433.Caci_1944	4.143e-10	63.0	2DG6U@1|root,2ZURF@2|Bacteria,2HCGM@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_252370_2	1347369.CCAD010000083_gene2752	1.605e-31	130.0	COG2050@1|root,COG2050@2|Bacteria,1VNH2@1239|Firmicutes,4I64C@91061|Bacilli,1ZGNM@1386|Bacillus	91061|Bacilli	Q	Domain of unknown function (DUF4442)	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
SHD1_k127_252370_0	471852.Tcur_2458	2.076e-122	398.0	COG0654@1|root,COG0654@2|Bacteria,2GM48@201174|Actinobacteria,4EG1V@85012|Streptosporangiales	201174|Actinobacteria	CH	FAD binding domain	-	-	1.14.13.2	ko:K00481	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R01298	RC00046	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3
SHD1_k127_2529509_0	1267534.KB906758_gene2260	0.0	1724.0	COG0308@1|root,COG1277@1|root,COG0308@2|Bacteria,COG1277@2|Bacteria	2|Bacteria	E	peptide catabolic process	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_4,Peptidase_M1
SHD1_k127_2529509_1	682795.AciX8_4477	9.422e-153	486.0	COG1131@1|root,COG1131@2|Bacteria,3Y7MQ@57723|Acidobacteria,2JMRW@204432|Acidobacteriia	204432|Acidobacteriia	V	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
SHD1_k127_2530615_1	861299.J421_3546	6.017e-212	669.0	COG2986@1|root,COG2986@2|Bacteria,1ZTEG@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Aromatic amino acid lyase	hutH	-	4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
SHD1_k127_2530615_0	379066.GAU_1936	1.782e-293	908.0	COG2987@1|root,COG2987@2|Bacteria,1ZSQX@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate	hutU	-	4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000	-	-	-	Urocanase,Urocanase_C,Urocanase_N
SHD1_k127_2530615_2	861299.J421_3544	6.79e-25	108.0	COG0535@1|root,COG0535@2|Bacteria,1ZT6Q@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
SHD1_k127_2561156_1	1538295.JY96_05170	3.396e-06	49.0	COG2062@1|root,COG2062@2|Bacteria,1RIVH@1224|Proteobacteria,2VSSQ@28216|Betaproteobacteria,1KM0H@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	Phosphoglycerate mutase family	sixA	-	-	ko:K08296	-	-	-	-	ko00000,ko01000	-	-	-	His_Phos_1
SHD1_k127_2561156_0	204773.HEAR1096	2.044e-30	124.0	COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,2VI1K@28216|Betaproteobacteria,472VH@75682|Oxalobacteraceae	28216|Betaproteobacteria	FP	Ppx/GppA phosphatase family	ppx	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	Ppx-GppA
SHD1_k127_2563562_2	1056512.D515_00447	1.843e-12	68.0	COG0414@1|root,COG0414@2|Bacteria,1MV1S@1224|Proteobacteria,1RMEG@1236|Gammaproteobacteria,1XT8P@135623|Vibrionales	135623|Vibrionales	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate	panC	GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_ligase
SHD1_k127_2563562_0	857293.CAAU_0952	7.538e-82	281.0	COG0413@1|root,COG0413@2|Bacteria,1TPZA@1239|Firmicutes,248RR@186801|Clostridia,36EKX@31979|Clostridiaceae	186801|Clostridia	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
SHD1_k127_2563562_1	358681.BBR47_01780	4.435e-31	127.0	COG0801@1|root,COG0801@2|Bacteria,1V6PR@1239|Firmicutes,4HIMG@91061|Bacilli,26USM@186822|Paenibacillaceae	91061|Bacilli	H	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	-	2.7.6.3	ko:K00950	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HPPK
SHD1_k127_2573581_8	861299.J421_2067	1.246e-12	76.0	2BYRT@1|root,345RZ@2|Bacteria,1ZU2R@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2573581_5	1379270.AUXF01000001_gene2349	3.44e-58	206.0	28NYH@1|root,2ZBVN@2|Bacteria,1ZTSS@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Disulphide isomerase	-	-	-	-	-	-	-	-	-	-	-	-	Disulph_isomer
SHD1_k127_2573581_4	1384054.N790_02960	6.457e-66	237.0	COG3279@1|root,COG3279@2|Bacteria,1MUE8@1224|Proteobacteria,1RMJJ@1236|Gammaproteobacteria,1X4GZ@135614|Xanthomonadales	135614|Xanthomonadales	KT	LytTr DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	LytTR,Response_reg
SHD1_k127_2573581_6	1121937.AUHJ01000008_gene1968	2.137e-55	208.0	COG2972@1|root,COG2972@2|Bacteria,1MXVQ@1224|Proteobacteria,1RQDA@1236|Gammaproteobacteria,465PG@72275|Alteromonadaceae	1236|Gammaproteobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K08082	ko02020,map02020	M00493	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,His_kinase
SHD1_k127_2573581_2	1250232.JQNJ01000001_gene3836	7.272e-106	368.0	COG2133@1|root,COG2133@2|Bacteria,4NEZC@976|Bacteroidetes,1HXFV@117743|Flavobacteriia	976|Bacteroidetes	G	Glucose sorbosone	-	-	-	ko:K21430	-	-	-	-	ko00000,ko01000	-	-	-	GSDH
SHD1_k127_2573581_1	379066.GAU_3054	4.465e-118	393.0	COG1668@1|root,COG1668@2|Bacteria,1ZTID@142182|Gemmatimonadetes	142182|Gemmatimonadetes	CP	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
SHD1_k127_2573581_0	861299.J421_2075	6.279e-134	439.0	COG4152@1|root,COG4152@2|Bacteria,1ZSSG@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
SHD1_k127_2573581_3	861299.J421_2076	1.165e-86	293.0	COG0555@1|root,COG0555@2|Bacteria	2|Bacteria	P	ATPase-coupled sulfate transmembrane transporter activity	wtpB	-	-	ko:K15496	ko02010,map02010	M00423	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.5	-	-	BPD_transp_1
SHD1_k127_2573581_7	1307759.JOMJ01000003_gene2343	1.555e-48	193.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,42MC0@68525|delta/epsilon subdivisions,2WJIC@28221|Deltaproteobacteria,2MAN2@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Belongs to the ABC transporter superfamily	cysA	-	3.6.3.25,3.6.3.29,3.6.3.55	ko:K02017,ko:K02045,ko:K15497	ko00920,ko02010,map00920,map02010	M00185,M00189,M00423	R10531	RC00002	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.6.1,3.A.1.6.3,3.A.1.6.5,3.A.1.8	-	-	ABC_tran,TOBE_2,TOBE_3
SHD1_k127_2588851_3	861299.J421_3895	4.759e-80	272.0	COG3437@1|root,COG3437@2|Bacteria,1ZSX2@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	HD,Response_reg
SHD1_k127_2588851_4	484770.UFO1_3917	1.043e-45	186.0	COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,4H3VD@909932|Negativicutes	909932|Negativicutes	NT	SMART chemotaxis sensory transducer, histidine kinase HAMP region domain protein	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,HAMP,MCPsignal
SHD1_k127_2588851_1	861299.J421_3894	1.147e-198	628.0	COG1109@1|root,COG1109@2|Bacteria,1ZSNW@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	Phosphoglucomutase/phosphomannomutase, C-terminal domain	-	-	5.4.2.8	ko:K01840	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01818	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
SHD1_k127_2588851_0	379066.GAU_2427	1.204e-304	942.0	COG0449@1|root,COG0449@2|Bacteria,1ZSTI@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
SHD1_k127_2588851_2	479434.Sthe_0598	1.318e-81	304.0	COG0457@1|root,COG2114@1|root,COG3899@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG3899@2|Bacteria,2G699@200795|Chloroflexi	200795|Chloroflexi	T	adenylyl cyclase class-3 4 guanylyl cyclase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,DZR,Guanylate_cyc
SHD1_k127_2594295_0	153721.MYP_1412	1.421e-170	568.0	COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria,4NESR@976|Bacteroidetes,47NMI@768503|Cytophagia	976|Bacteroidetes	L	DNA polymerase Ligase (LigD)	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
SHD1_k127_2595086_1	379066.GAU_1379	4.239e-37	142.0	COG3794@1|root,COG3794@2|Bacteria	2|Bacteria	C	PFAM blue (type 1) copper domain protein	amcY	GO:0005575,GO:0005623,GO:0042597,GO:0044464	1.7.2.1	ko:K00368	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000	-	-	-	Copper-bind,Cupredoxin_1
SHD1_k127_2595086_2	1541065.JRFE01000058_gene5541	2.338e-05	53.0	2DBIE@1|root,32ZYG@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2595086_0	861299.J421_6024	3.78e-70	248.0	COG4447@1|root,COG4447@2|Bacteria,1ZUJ5@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Sortilin, neurotensin receptor 3,	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
SHD1_k127_2597110_2	682795.AciX8_2560	7.5e-17	84.0	COG1835@1|root,COG1835@2|Bacteria,3Y5EG@57723|Acidobacteria,2JJNH@204432|Acidobacteriia	204432|Acidobacteriia	I	PFAM acyltransferase 3	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
SHD1_k127_2597110_3	452638.Pnec_0410	2.319e-15	90.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2VI4Q@28216|Betaproteobacteria,1K1RF@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Belongs to the peptidase S1C family	mucD	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
SHD1_k127_2597110_0	1267535.KB906767_gene2401	1.211e-108	369.0	COG2148@1|root,COG2148@2|Bacteria,3Y3GZ@57723|Acidobacteria,2JIAU@204432|Acidobacteriia	204432|Acidobacteriia	M	Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf,CoA_binding_3
SHD1_k127_2597110_1	1306174.JODP01000001_gene4679	1.622e-19	98.0	2E4BC@1|root,32Z70@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4184)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4184
SHD1_k127_2602766_4	861299.J421_3508	9.53e-24	101.0	COG2256@1|root,COG2256@2|Bacteria,1ZTCA@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	MgsA AAA+ ATPase C terminal	-	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA_assoc_2,MgsA_C,RuvB_N
SHD1_k127_2602766_3	861299.J421_3507	7.506e-45	168.0	COG5608@1|root,COG5608@2|Bacteria,1ZTWB@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Late embryogenesis abundant protein	-	-	-	-	-	-	-	-	-	-	-	-	LEA_2
SHD1_k127_2602766_0	861299.J421_3506	1.927e-173	558.0	COG2262@1|root,COG2262@2|Bacteria,1ZSYM@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
SHD1_k127_2602766_2	671143.DAMO_0766	3.152e-48	195.0	COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,2NNUW@2323|unclassified Bacteria	2|Bacteria	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	pcmB	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6,1.97.1.9	ko:K03388,ko:K12527	ko00450,ko00680,ko01100,ko01120,ko01200,map00450,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R07229,R11928,R11931,R11943,R11944	RC00011,RC02420	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_20,FlpD,Pyr_redox_2,Pyr_redox_3
SHD1_k127_2602766_1	861299.J421_3569	1.453e-135	438.0	COG0677@1|root,COG0677@2|Bacteria,1ZT42@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	UDP binding domain	-	-	1.1.1.136	ko:K13015	ko00520,map00520	-	R00421	RC00291	ko00000,ko00001,ko01000,ko01005	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
SHD1_k127_2620156_3	861299.J421_3931	1.236e-62	218.0	COG2086@1|root,COG2086@2|Bacteria,1ZT51@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Electron transfer flavoprotein domain	-	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
SHD1_k127_2620156_1	861299.J421_3930	1.557e-123	404.0	COG2025@1|root,COG2025@2|Bacteria,1ZTDU@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Electron transfer flavoprotein domain	-	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
SHD1_k127_2620156_0	1379270.AUXF01000003_gene3458	1.633e-272	854.0	COG0247@1|root,COG0247@2|Bacteria,1ZSVB@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG
SHD1_k127_2620156_2	2002.JOEQ01000003_gene2490	6.175e-122	396.0	COG0031@1|root,COG0031@2|Bacteria,2GIXE@201174|Actinobacteria,4EI60@85012|Streptosporangiales	201174|Actinobacteria	EK	Pyridoxal-phosphate dependent enzyme	-	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
SHD1_k127_2621861_0	861299.J421_3380	0.0	1052.0	COG0046@1|root,COG0046@2|Bacteria,1ZT8W@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
SHD1_k127_2621861_1	861299.J421_3378	2.143e-103	344.0	COG0047@1|root,COG0047@2|Bacteria,1ZTF8@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purQ	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
SHD1_k127_2621861_3	861299.J421_3377	2.863e-28	115.0	COG1828@1|root,COG1828@2|Bacteria,1ZU3W@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purS	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	PurS
SHD1_k127_2621861_2	1379270.AUXF01000006_gene156	8.135e-57	205.0	COG1183@1|root,COG1183@2|Bacteria,1ZTJP@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	CDP-alcohol phosphatidyltransferase	-	-	2.7.8.8	ko:K17103	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	M00093	R01800	RC00002,RC00017,RC02795	ko00000,ko00001,ko00002,ko01000	-	-	-	CDP-OH_P_transf
SHD1_k127_2663172_2	518766.Rmar_0409	1.935e-19	103.0	COG4099@1|root,COG4099@2|Bacteria,4NFSH@976|Bacteroidetes	976|Bacteroidetes	E	Phospholipase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_2,DLH,Esterase,Peptidase_S9
SHD1_k127_2663172_0	1089550.ATTH01000001_gene237	1.458e-132	445.0	COG0308@1|root,COG0308@2|Bacteria,4NFNJ@976|Bacteroidetes	976|Bacteroidetes	E	Peptidase family M1 domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1
SHD1_k127_2663172_3	518766.Rmar_1830	5.052e-18	86.0	COG0308@1|root,COG0308@2|Bacteria,4NFNJ@976|Bacteroidetes,1FK1K@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	E	Peptidase family M1 domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1
SHD1_k127_2663172_1	861299.J421_6024	2.013e-128	420.0	COG4447@1|root,COG4447@2|Bacteria,1ZUJ5@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Sortilin, neurotensin receptor 3,	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
SHD1_k127_2670672_2	580340.Tlie_0063	1.949e-87	302.0	COG1322@1|root,COG1322@2|Bacteria,3T9XJ@508458|Synergistetes	508458|Synergistetes	S	PFAM RmuC family	-	-	-	ko:K09760	-	-	-	-	ko00000	-	-	-	RmuC
SHD1_k127_2670672_1	1254432.SCE1572_49140	4.771e-100	353.0	COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,42PEY@68525|delta/epsilon subdivisions,2WJJ3@28221|Deltaproteobacteria,2YUIV@29|Myxococcales	28221|Deltaproteobacteria	S	metal-dependent hydrolase with the TIM-barrel fold	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
SHD1_k127_2670672_3	861299.J421_4072	6.076e-23	110.0	COG2010@1|root,COG2010@2|Bacteria,1ZU6E@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	ko:K00406	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	Cytochrome_CBB3,FixP_N
SHD1_k127_2670672_0	861299.J421_4070	2.537e-220	694.0	COG4993@1|root,COG4993@2|Bacteria	2|Bacteria	G	Dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	PQQ,PQQ_2
SHD1_k127_2678777_0	68170.KL590510_gene7215	2.744e-81	276.0	COG3647@1|root,COG3647@2|Bacteria,2IATE@201174|Actinobacteria,4E3YF@85010|Pseudonocardiales	201174|Actinobacteria	S	Predicted membrane protein (DUF2238)	-	-	-	ko:K08984	-	-	-	-	ko00000	-	-	-	DUF2238
SHD1_k127_2678777_1	1123242.JH636436_gene139	2.695e-78	281.0	COG1408@1|root,COG1408@2|Bacteria,2J0HU@203682|Planctomycetes	203682|Planctomycetes	S	metallophosphoesterase	-	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos
SHD1_k127_2678777_2	861299.J421_0983	7.16e-12	72.0	COG3153@1|root,COG3153@2|Bacteria,1ZUZD@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10
SHD1_k127_2681426_1	861299.J421_4357	7.85e-126	422.0	COG0577@1|root,COG0577@2|Bacteria,1ZURT@142182|Gemmatimonadetes	142182|Gemmatimonadetes	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
SHD1_k127_2681426_2	861299.J421_4358	4.667e-89	300.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
SHD1_k127_2681426_0	1122963.AUHB01000016_gene4364	2.772e-149	481.0	COG2070@1|root,COG2070@2|Bacteria,1MWPC@1224|Proteobacteria,2TQRT@28211|Alphaproteobacteria,370DW@31993|Methylocystaceae	28211|Alphaproteobacteria	S	Nitronate monooxygenase	-	-	1.13.12.16,1.3.1.9	ko:K00459,ko:K02371	ko00061,ko00910,ko01100,ko01212,map00061,map00910,map01100,map01212	M00083	R00025,R04429,R04724,R04955,R04958,R04961,R04966,R04969,R07765	RC00052,RC00076,RC02541,RC02759	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	NMO
SHD1_k127_2681426_3	1476876.JOJO01000038_gene5975	1.966e-09	58.0	COG0596@1|root,COG0596@2|Bacteria,2GK79@201174|Actinobacteria	201174|Actinobacteria	K	epoxide hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	EHN
SHD1_k127_2684710_4	379066.GAU_1399	1.699e-14	85.0	COG0060@1|root,COG0060@2|Bacteria,1ZSKS@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
SHD1_k127_2684710_0	379066.GAU_1398	1.508e-117	392.0	COG0005@1|root,COG0005@2|Bacteria,1ZUII@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate	-	-	2.4.2.1	ko:K03783	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244	RC00033,RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
SHD1_k127_2684710_3	1379270.AUXF01000005_gene659	2.877e-50	187.0	COG3599@1|root,COG3599@2|Bacteria,1ZUSD@142182|Gemmatimonadetes	142182|Gemmatimonadetes	D	DivIVA protein	-	-	-	ko:K04074	-	-	-	-	ko00000,ko03036	-	-	-	DivIVA
SHD1_k127_2684710_1	861299.J421_3047	1.289e-92	308.0	COG0325@1|root,COG3599@1|root,COG0325@2|Bacteria,COG3599@2|Bacteria,1ZTJZ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	D	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis	-	-	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
SHD1_k127_2684710_2	861299.J421_3046	3.049e-88	306.0	COG0659@1|root,COG2976@1|root,COG0659@2|Bacteria,COG2976@2|Bacteria	2|Bacteria	CO	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_21,TPR_6,TPR_8
SHD1_k127_268775_2	1379270.AUXF01000001_gene2790	1.272e-60	217.0	COG1651@1|root,COG1651@2|Bacteria,1ZTKP@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	DSBA-like thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_4
SHD1_k127_268775_5	292459.STH2564	1.341e-15	83.0	COG4243@1|root,COG4243@2|Bacteria	2|Bacteria	S	quinone binding	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_4,VKOR
SHD1_k127_268775_3	861299.J421_4197	1.649e-43	163.0	2FK78@1|root,34BUZ@2|Bacteria,1ZU15@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_268775_1	196367.JNFG01000207_gene37	1.278e-69	242.0	COG0454@1|root,COG0456@2|Bacteria,1RBE6@1224|Proteobacteria,2VQXS@28216|Betaproteobacteria,1K1II@119060|Burkholderiaceae	28216|Betaproteobacteria	K	PFAM GCN5-related N-acetyltransferase	ttr	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
SHD1_k127_268775_0	861299.J421_4196	0.0	1030.0	COG0365@1|root,COG0365@2|Bacteria,1ZSUU@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
SHD1_k127_268775_4	402881.Plav_1720	3.878e-20	102.0	COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,2TRAA@28211|Alphaproteobacteria,1JN4T@119043|Rhodobiaceae	28211|Alphaproteobacteria	L	Phage integrase, N-terminal SAM-like domain	xerD	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
SHD1_k127_268775_6	379066.GAU_2599	3.182e-15	80.0	COG1131@1|root,COG1131@2|Bacteria,1ZTRV@142182|Gemmatimonadetes	142182|Gemmatimonadetes	V	ABC transporter	-	-	3.6.3.41	ko:K02193	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.107	-	-	ABC_tran
SHD1_k127_2708095_1	861299.J421_3356	3.632e-92	307.0	COG0173@1|root,COG0173@2|Bacteria,1ZTFX@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
SHD1_k127_2708095_0	861299.J421_3355	5.415e-141	454.0	COG1702@1|root,COG1702@2|Bacteria,1ZSSD@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	PhoH-like protein	-	-	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
SHD1_k127_2708095_2	861299.J421_3354	5.78e-18	90.0	COG1480@1|root,COG1480@2|Bacteria	2|Bacteria	O	7TM receptor with intracellular HD hydrolase	yqfF	-	-	ko:K07037	-	-	-	-	ko00000	-	-	-	7TM-7TMR_HD,7TMR-HDED,HD
SHD1_k127_2710802_1	861299.J421_1261	1.079e-142	471.0	COG0612@1|root,COG0612@2|Bacteria,1ZT7N@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Peptidase M16 inactive domain	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16_C
SHD1_k127_2710802_0	861299.J421_1260	3.594e-186	593.0	COG0612@1|root,COG0612@2|Bacteria,1ZT1J@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Insulinase (Peptidase family M16)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
SHD1_k127_2710802_2	861299.J421_0294	1.745e-47	184.0	COG1725@1|root,COG1725@2|Bacteria	2|Bacteria	K	Transcriptional regulator	-	-	-	ko:K07979	-	-	-	-	ko00000,ko03000	-	-	-	GntR
SHD1_k127_2711975_3	861299.J421_2693	4.573e-28	122.0	COG2380@1|root,COG2380@2|Bacteria,1ZUZS@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	COGs COG2380 conserved	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2711975_4	379066.GAU_0772	1.743e-19	103.0	2AEW9@1|root,314TW@2|Bacteria,1ZUKZ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2711975_2	1050202.KB913024_gene171	1.043e-84	299.0	COG0436@1|root,COG0436@2|Bacteria,2GJ7R@201174|Actinobacteria,407Y6@622450|Actinopolysporales	201174|Actinobacteria	E	DegT/DnrJ/EryC1/StrS aminotransferase family	aspC	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
SHD1_k127_2711975_0	861299.J421_2689	2.531e-94	333.0	COG0513@1|root,COG0513@2|Bacteria,1ZTQP@142182|Gemmatimonadetes	142182|Gemmatimonadetes	JKL	DbpA RNA binding domain	-	-	3.6.4.13	ko:K05592	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DbpA
SHD1_k127_2711975_1	379066.GAU_0768	7.596e-88	293.0	COG1435@1|root,COG1435@2|Bacteria,1ZTB2@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Thymidine kinase	tdk	-	2.7.1.21	ko:K00857	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01567,R02099,R08233	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	TK
SHD1_k127_2711975_5	861299.J421_2687	2.484e-15	78.0	COG0237@1|root,COG0237@2|Bacteria,1ZTM2@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	-	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CoaE
SHD1_k127_271628_5	1096930.L284_11030	2.653e-06	60.0	2C1UQ@1|root,33VUD@2|Bacteria,1RM45@1224|Proteobacteria,2UBKR@28211|Alphaproteobacteria,2K9TG@204457|Sphingomonadales	204457|Sphingomonadales	S	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
SHD1_k127_271628_4	861299.J421_0347	1.129e-37	148.0	COG5403@1|root,COG5403@2|Bacteria	2|Bacteria	S	Bacterial protein of unknown function (DUF937)	-	-	-	-	-	-	-	-	-	-	-	-	DUF937
SHD1_k127_271628_0	379066.GAU_1432	1.1e-211	669.0	COG0531@1|root,COG0531@2|Bacteria,1ZSUB@142182|Gemmatimonadetes	2|Bacteria	E	C-terminus of AA_permease	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
SHD1_k127_271628_3	861299.J421_0342	2.674e-61	231.0	COG0642@1|root,COG2205@2|Bacteria,1ZUZJ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
SHD1_k127_271628_2	861299.J421_0341	1.542e-77	274.0	COG0745@1|root,COG0745@2|Bacteria,1ZUFQ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
SHD1_k127_271628_1	1379270.AUXF01000002_gene1600	7.406e-119	396.0	COG0515@1|root,COG0515@2|Bacteria	1379270.AUXF01000002_gene1600|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2719859_2	448385.sce4795	1.37e-27	121.0	COG2265@1|root,COG2265@2|Bacteria	2|Bacteria	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_12,Methyltransf_25,Methyltransf_31
SHD1_k127_2719859_0	448385.sce4796	1.108e-109	359.0	COG1143@1|root,COG3260@1|root,COG1143@2|Bacteria,COG3260@2|Bacteria,1QUBE@1224|Proteobacteria,42NH3@68525|delta/epsilon subdivisions,2WJX8@28221|Deltaproteobacteria,2YZYI@29|Myxococcales	28221|Deltaproteobacteria	C	NADH ubiquinone oxidoreductase, 20 Kd subunit	ehrS	-	-	-	-	-	-	-	-	-	-	iAF987.Gmet_2596	Fer4,Fer4_7,Oxidored_q6
SHD1_k127_2719859_1	448385.sce4797	8.453e-33	126.0	COG0852@1|root,COG3261@1|root,COG0852@2|Bacteria,COG3261@2|Bacteria,1QUBF@1224|Proteobacteria,42NJH@68525|delta/epsilon subdivisions,2WJ6J@28221|Deltaproteobacteria,2YZIA@29|Myxococcales	28221|Deltaproteobacteria	C	Respiratory-chain NADH dehydrogenase, 49 Kd subunit	ehrL	-	-	-	-	-	-	-	-	-	-	-	Complex1_30kDa,Complex1_49kDa
SHD1_k127_2727139_0	525897.Dbac_1184	5.404e-184	589.0	COG0665@1|root,COG0723@1|root,COG0665@2|Bacteria,COG0723@2|Bacteria,1MVRR@1224|Proteobacteria,42NSC@68525|delta/epsilon subdivisions,2WMAX@28221|Deltaproteobacteria,2MBD3@213115|Desulfovibrionales	28221|Deltaproteobacteria	CE	PFAM FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO,Rieske
SHD1_k127_2727139_2	3067.XP_002955027.1	5.8e-05	55.0	COG1310@1|root,KOG1555@2759|Eukaryota,37MY8@33090|Viridiplantae,34KYE@3041|Chlorophyta	3041|Chlorophyta	O	Prokaryotic homologs of the JAB domain	-	-	-	ko:K11864	ko03440,ko04621,map03440,map04621	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03036,ko03400,ko04121	-	-	-	JAB
SHD1_k127_2727139_1	251229.Chro_1492	5.241e-53	197.0	COG0664@1|root,COG0664@2|Bacteria,1G1UQ@1117|Cyanobacteria,3VJMP@52604|Pleurocapsales	1117|Cyanobacteria	K	COGs COG0664 cAMP-binding protein - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2
SHD1_k127_2729675_2	587753.EY04_20585	4.926e-07	57.0	COG4319@1|root,COG4319@2|Bacteria,1NF5T@1224|Proteobacteria,1SD49@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2729675_0	1123354.AUDR01000012_gene1855	2.546e-44	169.0	COG2050@1|root,COG2050@2|Bacteria,1RGVD@1224|Proteobacteria,2VRED@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	protein, possibly involved in aromatic compounds catabolism	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
SHD1_k127_2729675_1	1379270.AUXF01000004_gene3086	2.309e-37	149.0	COG0457@1|root,COG0457@2|Bacteria,1ZTR4@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2731343_0	272134.KB731324_gene4075	7.774e-142	462.0	COG1232@1|root,COG1232@2|Bacteria,1G465@1117|Cyanobacteria,1H9AU@1150|Oscillatoriales	1117|Cyanobacteria	H	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
SHD1_k127_2731343_1	272134.KB731324_gene4071	2.064e-30	123.0	COG0726@1|root,COG0726@2|Bacteria,1G3JU@1117|Cyanobacteria,1HABD@1150|Oscillatoriales	1117|Cyanobacteria	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
SHD1_k127_2771156_0	861299.J421_2844	1.084e-164	539.0	COG0860@1|root,COG0860@2|Bacteria,1ZT6J@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	Ami_3	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_3
SHD1_k127_2781533_1	861299.J421_3092	4.679e-58	204.0	COG1694@1|root,COG3956@2|Bacteria,1ZSZH@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	MazG nucleotide pyrophosphohydrolase domain	-	-	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	MazG
SHD1_k127_2781533_0	861299.J421_3093	2.54e-119	396.0	COG0787@1|root,COG0787@2|Bacteria,1ZT57@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	-	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
SHD1_k127_2781533_3	861299.J421_3095	2.833e-35	144.0	COG0295@1|root,COG0295@2|Bacteria,1ZTZY@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis	-	-	3.5.4.5	ko:K01489	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01878,R02485,R08221	RC00074,RC00514	ko00000,ko00001,ko01000	-	-	-	dCMP_cyt_deam_1
SHD1_k127_2781533_2	379066.GAU_1452	7.775e-38	159.0	2F0K0@1|root,33TNP@2|Bacteria,1ZTJU@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2786716_4	861299.J421_3380	2.69e-58	207.0	COG0046@1|root,COG0046@2|Bacteria,1ZT8W@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
SHD1_k127_2786716_1	861299.J421_3381	9.271e-226	706.0	COG0034@1|root,COG0034@2|Bacteria,1ZTD7@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6
SHD1_k127_2786716_0	1379270.AUXF01000006_gene151	0.0	1251.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1ZU89@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	Pyruvate phosphate dikinase, PEP/pyruvate binding domain	-	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
SHD1_k127_2786716_6	1353529.M899_1295	1.625e-24	103.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,42NDJ@68525|delta/epsilon subdivisions,2MSPP@213481|Bdellovibrionales,2WJSH@28221|Deltaproteobacteria	213481|Bdellovibrionales	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
SHD1_k127_2786716_3	1123368.AUIS01000009_gene2440	4.136e-84	287.0	COG2129@1|root,COG2129@2|Bacteria,1MVNK@1224|Proteobacteria	1224|Proteobacteria	S	metallophosphoesterase	-	-	-	ko:K07096	-	-	-	-	ko00000	-	-	-	Metallophos,Metallophos_2
SHD1_k127_2786716_2	1123368.AUIS01000009_gene2441	5.17e-97	328.0	COG4914@1|root,COG4914@2|Bacteria,1QX3W@1224|Proteobacteria	1224|Proteobacteria	S	Uncharacterised nucleotidyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	DUF2204,NTP_transf_5
SHD1_k127_2786716_5	340.xcc-b100_2852	3.515e-38	161.0	COG2199@1|root,COG5278@1|root,COG3706@2|Bacteria,COG5278@2|Bacteria,1NECV@1224|Proteobacteria,1S1ZR@1236|Gammaproteobacteria,1X6MM@135614|Xanthomonadales	135614|Xanthomonadales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,GAF_2,GGDEF
SHD1_k127_2800072_1	743836.AYNA01000038_gene821	1.806e-41	156.0	2BW4Q@1|root,32QZ0@2|Bacteria,1N1UX@1224|Proteobacteria,2UNAT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	MAPEG family	-	-	-	-	-	-	-	-	-	-	-	-	MAPEG
SHD1_k127_2800072_0	1121015.N789_13245	5.087e-65	226.0	2CCCK@1|root,2Z7UH@2|Bacteria,1R3SV@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	AurF
SHD1_k127_2811385_2	1379270.AUXF01000001_gene2850	1.326e-116	400.0	COG1572@1|root,COG1572@2|Bacteria	2|Bacteria	NU	bacterial-type flagellum-dependent cell motility	-	-	-	-	-	-	-	-	-	-	-	-	ASH,CARDB,F5_F8_type_C,PKD,PPC,Peptidase_C2,Peptidase_M66,Peptidase_S8,fn3
SHD1_k127_2811385_8	1370121.AUWS01000020_gene6743	7.628e-13	77.0	COG1309@1|root,COG1309@2|Bacteria,2GNR9@201174|Actinobacteria,236GA@1762|Mycobacteriaceae	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
SHD1_k127_2811385_3	861299.J421_6089	8.422e-109	369.0	COG1073@1|root,COG1680@1|root,COG1073@2|Bacteria,COG1680@2|Bacteria,1ZU86@142182|Gemmatimonadetes	2|Bacteria	V	Domain of unknown function (DUF3471)	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Beta-lactamase,DUF3471,Hydrolase_4
SHD1_k127_2811385_10	243164.DET1552	7.896e-06	51.0	COG1961@1|root,COG1961@2|Bacteria,2G7BH@200795|Chloroflexi,34DMJ@301297|Dehalococcoidia	301297|Dehalococcoidia	L	Recombinase zinc beta ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
SHD1_k127_2811385_4	1379270.AUXF01000001_gene2680	3.882e-85	293.0	COG1171@1|root,COG1171@2|Bacteria,1ZUF1@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Pyridoxal-phosphate dependent enzyme	-	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
SHD1_k127_2811385_0	1009370.ALO_13010	1.47e-139	465.0	COG1807@1|root,COG1807@2|Bacteria,1U208@1239|Firmicutes,4H5XY@909932|Negativicutes	909932|Negativicutes	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
SHD1_k127_2811385_1	861299.J421_4331	4.59e-134	434.0	COG1234@1|root,COG1234@2|Bacteria,1ZTG7@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA	rnz	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
SHD1_k127_2811385_7	861299.J421_4333	9.724e-29	121.0	COG4911@1|root,COG4911@2|Bacteria	2|Bacteria	S	Uncharacterized conserved protein (DUF2203)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2203
SHD1_k127_2811385_6	861299.J421_4334	4.211e-33	141.0	COG1607@1|root,COG1607@2|Bacteria,1ZTQ1@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
SHD1_k127_2811385_5	1379270.AUXF01000001_gene2674	8.622e-40	160.0	2F1E3@1|root,33UEU@2|Bacteria,1ZTQT@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2815131_0	1304275.C41B8_17868	2.632e-170	544.0	COG1236@1|root,COG1236@2|Bacteria,1MUDD@1224|Proteobacteria,1RPZC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	exonuclease of the beta-lactamase fold involved in RNA processing	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,RMMBL
SHD1_k127_2815131_2	1255043.TVNIR_1504	1.893e-21	102.0	COG1734@1|root,COG1734@2|Bacteria,1NH80@1224|Proteobacteria,1SAW8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	dksA traR	-	-	-	-	-	-	-	-	-	-	-	-	zf-dskA_traR
SHD1_k127_2815131_1	1123354.AUDR01000016_gene1317	9.821e-49	183.0	COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,2VIW1@28216|Betaproteobacteria,1KRGZ@119069|Hydrogenophilales	119069|Hydrogenophilales	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
SHD1_k127_2816588_0	452637.Oter_1883	3.983e-151	505.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
SHD1_k127_2816588_3	379066.GAU_2624	1.446e-39	154.0	COG1225@1|root,COG1225@2|Bacteria,1ZUGC@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
SHD1_k127_2816588_2	926550.CLDAP_10140	2.136e-44	171.0	COG4585@1|root,COG4585@2|Bacteria,2G8N5@200795|Chloroflexi	200795|Chloroflexi	T	PFAM ATP-binding region, ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
SHD1_k127_2816588_1	357808.RoseRS_3278	1.885e-49	185.0	COG2197@1|root,COG2197@2|Bacteria,2G8NX@200795|Chloroflexi	200795|Chloroflexi	K	Two component transcriptional regulator, LuxR family	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
SHD1_k127_2846375_1	1502852.FG94_03247	3.77e-92	310.0	COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,2VHHZ@28216|Betaproteobacteria,473Z4@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
SHD1_k127_2846375_0	861299.J421_2518	4.495e-240	749.0	COG1239@1|root,COG1239@2|Bacteria,1ZT0R@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX	-	-	6.6.1.1	ko:K03405	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03877	RC01012	ko00000,ko00001,ko01000	-	-	-	-
SHD1_k127_2846375_3	1507.HMPREF0262_03146	1.158e-18	95.0	COG1102@1|root,COG1102@2|Bacteria,1TRCW@1239|Firmicutes,249VD@186801|Clostridia,36JSF@31979|Clostridiaceae	186801|Clostridia	F	Cytidylate kinase-like family	-	-	-	-	-	-	-	-	-	-	-	-	Cytidylate_kin2
SHD1_k127_2854705_6	1294273.roselon_02796	8.382e-29	118.0	COG2010@1|root,COG2010@2|Bacteria,1QVIB@1224|Proteobacteria,2TX5M@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
SHD1_k127_2854705_2	379066.GAU_1183	4.851e-74	262.0	COG0664@1|root,COG0664@2|Bacteria,1ZTHA@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	helix_turn_helix, cAMP Regulatory protein	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
SHD1_k127_2854705_3	1396141.BATP01000003_gene5111	1.592e-61	222.0	COG0745@1|root,COG1235@1|root,COG2203@1|root,COG0745@2|Bacteria,COG1235@2|Bacteria,COG2203@2|Bacteria,46UKB@74201|Verrucomicrobia,2IVU2@203494|Verrucomicrobiae	203494|Verrucomicrobiae	KT	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2,Response_reg
SHD1_k127_2854705_8	1278073.MYSTI_04051	9.041e-07	59.0	COG5616@1|root,COG5616@2|Bacteria,1QW0Q@1224|Proteobacteria,43303@68525|delta/epsilon subdivisions,2WXN6@28221|Deltaproteobacteria,2Z1XR@29|Myxococcales	28221|Deltaproteobacteria	S	Curli production assembly/transport component CsgG	-	-	-	-	-	-	-	-	-	-	-	-	CsgG
SHD1_k127_2854705_5	861299.J421_0336	6.979e-31	124.0	COG1695@1|root,COG1695@2|Bacteria	2|Bacteria	K	negative regulation of transcription, DNA-templated	-	-	-	-	-	-	-	-	-	-	-	-	PadR
SHD1_k127_2854705_0	215803.DB30_7235	7.717e-209	679.0	COG0577@1|root,COG0577@2|Bacteria,1NREW@1224|Proteobacteria,433ZM@68525|delta/epsilon subdivisions,2X48T@28221|Deltaproteobacteria,2YYI5@29|Myxococcales	1224|Proteobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
SHD1_k127_2854705_4	1267534.KB906758_gene2285	2.197e-53	193.0	COG3832@1|root,COG3832@2|Bacteria	2|Bacteria	J	glyoxalase III activity	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
SHD1_k127_2854705_7	1267534.KB906758_gene2286	1.151e-27	115.0	COG0640@1|root,COG0640@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
SHD1_k127_2854705_1	861299.J421_2933	1.189e-172	550.0	COG0146@1|root,COG0146@2|Bacteria,1ZTH4@142182|Gemmatimonadetes	142182|Gemmatimonadetes	EQ	Hydantoinase B/oxoprolinase	-	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
SHD1_k127_2864247_0	861299.J421_2981	0.0	1092.0	COG1199@1|root,COG2003@1|root,COG1199@2|Bacteria,COG2003@2|Bacteria,1ZT1S@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	HELICc2	-	-	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Helicase_C_2,RadC
SHD1_k127_2864247_4	861299.J421_2983	8.71e-88	297.0	COG0179@1|root,COG0179@2|Bacteria,1ZTIG@142182|Gemmatimonadetes	142182|Gemmatimonadetes	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
SHD1_k127_2864247_2	861299.J421_3701	4e-185	586.0	COG0436@1|root,COG0436@2|Bacteria,1ZTCU@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Aminotransferase class I and II	-	-	2.6.1.83	ko:K10206	ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230	M00527	R07613	RC00006,RC01847	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
SHD1_k127_2864247_7	861299.J421_2984	6.357e-34	145.0	2FFNT@1|root,347K5@2|Bacteria,1ZTY9@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2864247_5	861299.J421_2985	5.524e-64	227.0	COG1974@1|root,COG1974@2|Bacteria	2|Bacteria	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	-	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	HTH_3,LexA_DNA_bind,Peptidase_S24
SHD1_k127_2864247_1	861299.J421_2986	7.385e-195	623.0	COG0008@1|root,COG0008@2|Bacteria,1ZSSX@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
SHD1_k127_2864247_3	469383.Cwoe_1219	1.629e-131	430.0	COG2141@1|root,COG2141@2|Bacteria,2ICDI@201174|Actinobacteria,4CU1Y@84995|Rubrobacteria	84995|Rubrobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
SHD1_k127_2864247_6	861299.J421_2988	2.213e-49	183.0	COG0457@1|root,COG0659@1|root,COG0457@2|Bacteria,COG0659@2|Bacteria	2|Bacteria	P	secondary active sulfate transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2874978_1	1379270.AUXF01000001_gene2645	9.396e-94	326.0	COG2197@1|root,COG3899@1|root,COG2197@2|Bacteria,COG3899@2|Bacteria	2|Bacteria	T	PFAM Protein kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
SHD1_k127_2874978_0	861299.J421_0892	8.26e-116	383.0	COG0076@1|root,COG0076@2|Bacteria,1ZTFP@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Pyridoxal-dependent decarboxylase conserved domain	-	-	4.1.1.86	ko:K13745	ko00260,ko01120,map00260,map01120	-	R07650	RC00299	ko00000,ko00001,ko01000	-	-	-	Pyridoxal_deC
SHD1_k127_2881092_7	1379270.AUXF01000006_gene204	3.164e-07	61.0	COG1573@1|root,COG1573@2|Bacteria,1ZTG5@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	Uracil DNA glycosylase superfamily	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
SHD1_k127_2881092_1	861299.J421_3319	3.709e-155	501.0	COG0452@1|root,COG0452@2|Bacteria,1ZV19@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	-	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
SHD1_k127_2881092_6	1379270.AUXF01000006_gene203	1.33e-21	96.0	28VAR@1|root,2ZHDJ@2|Bacteria,1ZU25@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits	rpoZ	-	-	-	-	-	-	-	-	-	-	-	RNA_pol_Rpb6
SHD1_k127_2881092_5	379066.GAU_1689	3.081e-77	266.0	COG0194@1|root,COG0194@2|Bacteria,1ZTV7@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Essential for recycling GMP and indirectly, cGMP	gmk	-	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
SHD1_k127_2881092_3	379066.GAU_1690	9.43e-98	327.0	COG1561@1|root,COG1561@2|Bacteria,1ZT99@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Domain of unknown function (DUF1732)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1732,YicC_N
SHD1_k127_2881092_2	861299.J421_3323	1.148e-103	364.0	COG4206@1|root,COG4206@2|Bacteria,1ZT1E@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	TonB-dependent Receptor Plug Domain	-	-	-	-	-	-	-	-	-	-	-	-	Plug
SHD1_k127_2881092_0	1379270.AUXF01000006_gene199	1.157e-171	553.0	COG0260@1|root,COG0260@2|Bacteria,1ZSPX@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
SHD1_k127_2881092_4	1379698.RBG1_1C00001G0798	3.057e-97	346.0	COG0308@1|root,COG1413@1|root,COG0308@2|Bacteria,COG1413@2|Bacteria,2NPGQ@2323|unclassified Bacteria	2|Bacteria	E	aminopeptidase	pepN	-	3.4.11.2	ko:K01256	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	HEAT_2,Peptidase_M1
SHD1_k127_2881520_2	1340493.JNIF01000003_gene4186	0.00055	46.0	COG2308@1|root,COG2308@2|Bacteria,3Y6VU@57723|Acidobacteria	57723|Acidobacteria	S	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2881520_1	926550.CLDAP_22640	2.381e-107	364.0	COG0189@1|root,COG0189@2|Bacteria,2G864@200795|Chloroflexi	200795|Chloroflexi	HJ	ligase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2881520_0	1121957.ATVL01000009_gene1201	1.04e-147	476.0	COG2170@1|root,COG2170@2|Bacteria,4NFFP@976|Bacteroidetes,47KG2@768503|Cytophagia	976|Bacteroidetes	S	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity	ybdK	-	-	ko:K06048	-	-	-	-	ko00000,ko01000	-	-	-	GCS2
SHD1_k127_2894739_4	195250.CM001776_gene3702	0.0006879	45.0	COG1995@1|root,COG1995@2|Bacteria,1G1U1@1117|Cyanobacteria,1GZ7N@1129|Synechococcus	1117|Cyanobacteria	H	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)	pdxA	-	1.1.1.262	ko:K00097	ko00750,ko01100,map00750,map01100	M00124	R05681,R05837,R07406	RC00089,RC00675,RC01475	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxA
SHD1_k127_2894739_3	292459.STH3229	6.255e-14	74.0	COG1188@1|root,COG1188@2|Bacteria,1VEI5@1239|Firmicutes,24QNF@186801|Clostridia	186801|Clostridia	J	S4 domain protein	hslR	-	-	-	-	-	-	-	-	-	-	-	S4
SHD1_k127_2894739_1	861299.J421_3745	1.274e-112	378.0	COG0760@1|root,COG0760@2|Bacteria,1ZSU2@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	SurA N-terminal domain	-	-	5.2.1.8	ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase_3,SurA_N_3
SHD1_k127_2894739_0	861299.J421_3746	6.244e-125	421.0	COG0760@1|root,COG0760@2|Bacteria,1ZT5S@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	PPIC-type PPIASE domain	-	-	5.2.1.8	ko:K03770	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase_3
SHD1_k127_2894739_2	861299.J421_3747	3.556e-109	357.0	COG1197@1|root,COG1197@2|Bacteria,1ZT88@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
SHD1_k127_2895770_2	1198452.Jab_1c09970	3.454e-55	201.0	arCOG07533@1|root,2ZF5I@2|Bacteria,1RB8D@1224|Proteobacteria,2W871@28216|Betaproteobacteria,477Z9@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Domain of unknown function (DUF4386)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4386
SHD1_k127_2895770_1	1248917.ANFX01000029_gene2653	3.038e-101	345.0	29X0I@1|root,30INU@2|Bacteria,1PNCD@1224|Proteobacteria,2V0YC@28211|Alphaproteobacteria,2KAXI@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2895770_0	1379270.AUXF01000002_gene1290	1.252e-192	625.0	COG0515@1|root,COG0515@2|Bacteria,1ZUFG@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
SHD1_k127_2905946_3	861299.J421_3331	5.046e-59	210.0	COG1595@1|root,COG1595@2|Bacteria,1ZTKV@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
SHD1_k127_2905946_2	1227739.Hsw_4133	2.912e-140	456.0	COG0183@1|root,COG0183@2|Bacteria,4NE3Q@976|Bacteroidetes,47JXM@768503|Cytophagia	976|Bacteroidetes	I	Belongs to the thiolase family	-	-	2.3.1.174,2.3.1.9	ko:K00626,ko:K07823	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R00829,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
SHD1_k127_2905946_4	861299.J421_3332	1.459e-44	179.0	COG0584@1|root,COG0584@2|Bacteria,1ZTTY@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Glycerophosphoryl diester phosphodiesterase family	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
SHD1_k127_2905946_0	861299.J421_3333	2.598e-218	696.0	COG1228@1|root,COG1228@2|Bacteria,1ZTC8@142182|Gemmatimonadetes	142182|Gemmatimonadetes	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
SHD1_k127_2905946_1	861299.J421_3334	1.865e-150	488.0	COG1228@1|root,COG1228@2|Bacteria,1ZTI7@142182|Gemmatimonadetes	861299.J421_3334|-	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2919172_4	861299.J421_5587	3.497e-55	209.0	COG0746@1|root,COG0746@2|Bacteria,1ZU64@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	mobA	-	2.7.7.77	ko:K03752	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
SHD1_k127_2919172_7	1408422.JHYF01000009_gene2173	3.447e-37	151.0	COG1526@1|root,COG1526@2|Bacteria,1TU8R@1239|Firmicutes,24G61@186801|Clostridia,36HJU@31979|Clostridiaceae	186801|Clostridia	C	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH	fdhD	-	-	ko:K02379	-	-	-	-	ko00000	-	-	-	FdhD-NarQ
SHD1_k127_2919172_6	379066.GAU_2460	2.843e-40	153.0	COG0720@1|root,COG0720@2|Bacteria,1ZTRR@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	6-pyruvoyl tetrahydropterin synthase	-	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
SHD1_k127_2919172_5	861299.J421_3923	4.308e-50	188.0	2F8UF@1|root,3416F@2|Bacteria,1ZTX9@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2919172_0	861299.J421_3922	9.77e-230	721.0	COG0696@1|root,COG0696@2|Bacteria,1ZSWH@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmI	-	5.4.2.12	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,Phosphodiest,iPGM_N
SHD1_k127_2919172_3	1379270.AUXF01000003_gene3468	1.434e-55	201.0	2A37A@1|root,30RNW@2|Bacteria,1ZUP6@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2919172_2	1379270.AUXF01000003_gene3469	3.629e-86	295.0	COG1376@1|root,COG1376@2|Bacteria,1ZUFC@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
SHD1_k127_2919172_1	379066.GAU_2455	2.495e-95	323.0	COG3108@1|root,COG3108@2|Bacteria,1ZTME@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Peptidase M15	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M15_3
SHD1_k127_2919172_9	1379270.AUXF01000003_gene3472	0.0006651	43.0	2F9BP@1|root,341NP@2|Bacteria,1ZTX1@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2919845_2	861299.J421_0670	8.538e-31	130.0	COG0412@1|root,COG0412@2|Bacteria,1ZT96@142182|Gemmatimonadetes	142182|Gemmatimonadetes	Q	Dienelactone hydrolase family	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
SHD1_k127_2919845_0	861299.J421_2451	9.232e-218	696.0	COG1574@1|root,COG1574@2|Bacteria,1ZTC9@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
SHD1_k127_2919845_1	1198114.AciX9_1187	6.008e-32	128.0	COG0492@1|root,COG3437@1|root,COG0492@2|Bacteria,COG3437@2|Bacteria,3Y3TK@57723|Acidobacteria,2JIM5@204432|Acidobacteriia	204432|Acidobacteriia	KOT	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_3,Response_reg
SHD1_k127_2920048_3	330214.NIDE2022	2.456e-20	106.0	COG0515@1|root,COG0515@2|Bacteria	330214.NIDE2022|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2920048_1	1379270.AUXF01000003_gene3840	4.882e-113	383.0	COG2202@1|root,COG4191@1|root,COG2202@2|Bacteria,COG4191@2|Bacteria,1ZTDZ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_4
SHD1_k127_2920048_0	1379270.AUXF01000003_gene3841	1.075e-166	547.0	COG2204@1|root,COG2204@2|Bacteria,1ZUM4@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	Sigma-54 interaction domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
SHD1_k127_2920048_2	861299.J421_3620	8.625e-109	360.0	COG0745@1|root,COG0745@2|Bacteria,1ZT8B@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Transcriptional regulatory protein, C terminal	-	-	-	ko:K02483,ko:K07665	ko02020,map02020	M00452,M00745	-	-	ko00000,ko00001,ko00002,ko01504,ko02022	-	-	-	Response_reg,Trans_reg_C
SHD1_k127_2920048_4	379066.GAU_2012	0.0001978	49.0	COG5002@1|root,COG5002@2|Bacteria,1ZTF2@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
SHD1_k127_2928266_3	1379270.AUXF01000005_gene723	1.132e-09	60.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1ZSNI@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	-	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
SHD1_k127_2928266_1	861299.J421_3115	3.544e-77	264.0	COG0307@1|root,COG0307@2|Bacteria,1ZTQM@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Lumazine binding domain	-	-	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	Lum_binding
SHD1_k127_2928266_0	436114.SYO3AOP1_1761	1.344e-150	495.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,2G3UE@200783|Aquificae	200783|Aquificae	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribBA	-	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2
SHD1_k127_2928266_2	861299.J421_3117	1.978e-54	198.0	COG0054@1|root,COG0054@2|Bacteria,1ZTPU@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	-	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
SHD1_k127_2942825_1	861299.J421_1340	2.718e-235	736.0	COG0312@1|root,COG0312@2|Bacteria,1ZSUE@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Putative modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD,TAT_signal
SHD1_k127_2942825_0	264732.Moth_2312	1.171e-242	783.0	COG3383@1|root,COG3383@2|Bacteria,1TT6D@1239|Firmicutes,24YN9@186801|Clostridia,42FDP@68295|Thermoanaerobacterales	186801|Clostridia	C	Formate dehydrogenase alpha subunit	fdhA	-	1.17.1.10,1.17.1.9	ko:K00123,ko:K05299	ko00630,ko00680,ko00720,ko01100,ko01120,ko01200,map00630,map00680,map00720,map01100,map01120,map01200	M00377	R00134,R00519	RC02796	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_4,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
SHD1_k127_2942825_3	886882.PPSC2_c2845	1.659e-58	212.0	COG1028@1|root,COG1028@2|Bacteria,1U2GS@1239|Firmicutes,4H9R9@91061|Bacilli,26QGX@186822|Paenibacillaceae	91061|Bacilli	IQ	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	fabG1	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
SHD1_k127_2942825_2	861299.J421_2612	1.627e-173	550.0	COG1063@1|root,COG1063@2|Bacteria,1ZSWB@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Zinc-binding dehydrogenase	-	-	1.1.1.103	ko:K00060	ko00260,map00260	-	R01465	RC00525	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
SHD1_k127_2965143_1	1121380.JNIW01000024_gene686	5.915e-15	77.0	COG3694@1|root,COG3694@2|Bacteria,1WJ2Z@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	transport system, permease component	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_6
SHD1_k127_2965143_4	330214.NIDE0149	1.998e-09	67.0	2ETF9@1|root,33KZ8@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4412)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4412
SHD1_k127_2965143_0	1303518.CCALI_01711	1.67e-50	187.0	2CMWR@1|root,32SFR@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2965143_2	1303518.CCALI_01712	3.118e-14	83.0	2934T@1|root,2ZQMY@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_2965143_3	671143.DAMO_0102	5.617e-14	77.0	COG4772@1|root,COG4772@2|Bacteria,2NRIP@2323|unclassified Bacteria	2|Bacteria	P	TonB dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
SHD1_k127_2965206_1	663610.JQKO01000013_gene1806	5.955e-145	475.0	COG2010@1|root,COG2133@1|root,COG2010@2|Bacteria,COG2133@2|Bacteria,1MVK5@1224|Proteobacteria,2TRN9@28211|Alphaproteobacteria,3N9Q5@45404|Beijerinckiaceae	28211|Alphaproteobacteria	C	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3,GSDH
SHD1_k127_2965206_3	861299.J421_1786	8.118e-51	201.0	COG3386@1|root,COG3386@2|Bacteria	2|Bacteria	G	gluconolactonase activity	-	-	3.1.1.17	ko:K01053	ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02933,R03751	RC00537,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	SGL
SHD1_k127_2965206_0	1396418.BATQ01000141_gene3368	3.96e-156	497.0	COG0667@1|root,COG0667@2|Bacteria,46SPV@74201|Verrucomicrobia,2ITQC@203494|Verrucomicrobiae	203494|Verrucomicrobiae	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
SHD1_k127_2965206_2	1128421.JAGA01000004_gene2519	1.054e-82	279.0	COG0693@1|root,COG0693@2|Bacteria,2NPFP@2323|unclassified Bacteria	2|Bacteria	S	DJ-1/PfpI family	pfpI	-	3.5.1.124	ko:K05520	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DJ-1_PfpI
SHD1_k127_2965206_4	1144275.COCOR_06656	6.093e-06	48.0	COG4319@1|root,COG4319@2|Bacteria,1R2GQ@1224|Proteobacteria	1224|Proteobacteria	S	ketosteroid isomerase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
SHD1_k127_2971515_1	861299.J421_2624	6.023e-116	380.0	COG0568@1|root,COG0568@2|Bacteria,1ZTCX@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
SHD1_k127_2971515_0	861299.J421_3342	0.0	1074.0	COG0826@1|root,COG0826@2|Bacteria,1ZTET@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	Collagenase	-	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3656,Peptidase_U32
SHD1_k127_3007329_2	861299.J421_4366	1.395e-20	100.0	COG1629@1|root,COG4771@2|Bacteria,1ZT7X@142182|Gemmatimonadetes	142182|Gemmatimonadetes	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
SHD1_k127_3007329_1	861299.J421_3995	5.479e-25	109.0	2DING@1|root,303QG@2|Bacteria,1ZV8G@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Cysteine-rich CPXCG	-	-	-	-	-	-	-	-	-	-	-	-	Cys_rich_CPXG
SHD1_k127_3007329_0	379066.GAU_3326	3.67e-99	330.0	COG2081@1|root,COG2081@2|Bacteria,1ZUAT@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	HI0933-like protein	-	-	-	ko:K07007	-	-	-	-	ko00000	-	-	-	HI0933_like
SHD1_k127_3013532_0	379066.GAU_0558	4.349e-257	801.0	COG0646@1|root,COG0685@1|root,COG0646@2|Bacteria,COG0685@2|Bacteria,1ZT6C@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Methylenetetrahydrofolate reductase	-	-	1.5.1.20,2.1.1.10	ko:K00297,ko:K00547	ko00270,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01523,map00270,map00670,map00720,map01100,map01110,map01120,map01200,map01523	M00377	R00650,R01224,R07168	RC00003,RC00035,RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR,S-methyl_trans
SHD1_k127_3013532_1	45157.CMH050CT	2.514e-20	96.0	COG2138@1|root,2RXIW@2759|Eukaryota	2759|Eukaryota	S	sirohydrochlorin cobaltochelatase activity	-	GO:0003674,GO:0003824,GO:0004325,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009058,GO:0009507,GO:0009536,GO:0009987,GO:0016829,GO:0018130,GO:0019354,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0042802,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046156,GO:0046483,GO:0048037,GO:0050896,GO:0051186,GO:0051188,GO:0051266,GO:0051536,GO:0051540,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.99.1.4	ko:K03794	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R02864	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	CbiX
SHD1_k127_3017006_14	926560.KE387025_gene4131	1.047e-73	258.0	COG1028@1|root,COG1028@2|Bacteria,1WM2Z@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
SHD1_k127_3017006_0	1210884.HG799464_gene10885	8.129e-236	739.0	COG1233@1|root,COG1233@2|Bacteria,2IX17@203682|Planctomycetes	203682|Planctomycetes	Q	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
SHD1_k127_3017006_7	1122137.AQXF01000003_gene2088	1.532e-130	443.0	COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,2U0BD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
SHD1_k127_3017006_3	1163409.UUA_08366	2.986e-145	474.0	COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,1RQRP@1236|Gammaproteobacteria,1X3Y7@135614|Xanthomonadales	135614|Xanthomonadales	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
SHD1_k127_3017006_5	324602.Caur_2349	3.672e-133	438.0	COG4638@1|root,COG4638@2|Bacteria,2G720@200795|Chloroflexi,377BT@32061|Chloroflexia	32061|Chloroflexia	P	PFAM Rieske 2Fe-2S domain protein	-	-	1.14.15.7	ko:K00479,ko:K00499	ko00260,map00260	-	R07409	RC00087	ko00000,ko00001,ko01000	-	-	-	Rieske,Ring_hydroxyl_A
SHD1_k127_3017006_12	596151.DesfrDRAFT_2708	2.698e-76	265.0	COG0024@1|root,COG0024@2|Bacteria,1MU99@1224|Proteobacteria,42MM5@68525|delta/epsilon subdivisions,2WJMN@28221|Deltaproteobacteria,2MB1D@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	Metallopeptidase family M24	-	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
SHD1_k127_3017006_11	1160137.KB907308_gene7539	1.337e-89	305.0	COG0702@1|root,COG0702@2|Bacteria,2HC75@201174|Actinobacteria,4G3DZ@85025|Nocardiaceae	201174|Actinobacteria	GM	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10,NmrA
SHD1_k127_3017006_6	1122612.AUBA01000002_gene1748	1.342e-130	434.0	COG0531@1|root,COG0531@2|Bacteria,1MUP1@1224|Proteobacteria,2U4MC@28211|Alphaproteobacteria,2KBDP@204457|Sphingomonadales	204457|Sphingomonadales	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
SHD1_k127_3017006_9	266117.Rxyl_1558	5.219e-113	378.0	COG0665@1|root,COG0665@2|Bacteria,2I9WR@201174|Actinobacteria,4CSWG@84995|Rubrobacteria	84995|Rubrobacteria	E	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
SHD1_k127_3017006_4	247634.GPB2148_1717	2.732e-137	448.0	COG4638@1|root,COG4638@2|Bacteria,1MWXW@1224|Proteobacteria,1RYN7@1236|Gammaproteobacteria,1JBXZ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	COG4638 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit	-	-	-	ko:K00479	-	-	-	-	ko00000	-	-	-	Rieske,Ring_hydroxyl_A
SHD1_k127_3017006_8	1382356.JQMP01000004_gene188	5.543e-115	383.0	COG0436@1|root,COG0436@2|Bacteria,2G5MC@200795|Chloroflexi,27YSW@189775|Thermomicrobia	189775|Thermomicrobia	E	Aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
SHD1_k127_3017006_13	1121448.DGI_1377	3.549e-75	274.0	COG0413@1|root,COG0413@2|Bacteria,1MU3B@1224|Proteobacteria,42MES@68525|delta/epsilon subdivisions,2WIQK@28221|Deltaproteobacteria,2M8WY@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
SHD1_k127_3017006_18	404589.Anae109_3606	9.596e-25	107.0	COG1977@1|root,COG1977@2|Bacteria	2|Bacteria	H	Mo-molybdopterin cofactor metabolic process	-	-	2.7.7.80,2.8.1.11	ko:K03636,ko:K21147	ko04122,map04122	-	R07459,R07461	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiS
SHD1_k127_3017006_1	290397.Adeh_3493	3.258e-177	563.0	COG0476@1|root,COG0607@1|root,COG0476@2|Bacteria,COG0607@2|Bacteria,1MW7H@1224|Proteobacteria,42NEC@68525|delta/epsilon subdivisions,2WK08@28221|Deltaproteobacteria,2YUA5@29|Myxococcales	28221|Deltaproteobacteria	HP	domain protein	moeB1	-	2.7.7.80,2.8.1.11	ko:K21147	ko04122,map04122	-	R07459,R07461	RC00043	ko00000,ko00001,ko01000	-	-	-	Rhodanese,ThiF
SHD1_k127_3017006_2	404589.Anae109_3605	1.024e-176	565.0	COG0498@1|root,COG0498@2|Bacteria,1MUWQ@1224|Proteobacteria,42M1W@68525|delta/epsilon subdivisions,2WK53@28221|Deltaproteobacteria,2YTVW@29|Myxococcales	28221|Deltaproteobacteria	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
SHD1_k127_3017006_17	861299.J421_0551	1.109e-31	137.0	2DNQD@1|root,32YJR@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF3303)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3303
SHD1_k127_3017006_10	1157490.EL26_19615	4.166e-102	343.0	COG4586@1|root,COG4586@2|Bacteria,1TP1N@1239|Firmicutes,4HEB4@91061|Bacilli,279KW@186823|Alicyclobacillaceae	91061|Bacilli	S	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SHD1_k127_3017006_15	235909.GK1488	6.867e-56	206.0	COG4587@1|root,COG4587@2|Bacteria,1VDUN@1239|Firmicutes,4HE8R@91061|Bacilli,1WFUH@129337|Geobacillus	91061|Bacilli	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_6
SHD1_k127_3017006_16	1122915.AUGY01000008_gene5085	9.19e-44	176.0	COG3694@1|root,COG3694@2|Bacteria,1UZ6K@1239|Firmicutes,4HCYU@91061|Bacilli,276WH@186822|Paenibacillaceae	91061|Bacilli	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_6
SHD1_k127_3018305_0	379066.GAU_1934	2.801e-114	378.0	COG1228@1|root,COG1228@2|Bacteria,1ZSNQ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Amidohydrolase family	hutI	-	3.5.2.7	ko:K01468	ko00340,ko01100,map00340,map01100	M00045	R02288	RC00683	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_3
SHD1_k127_3018305_1	861299.J421_3544	5.127e-103	339.0	COG0535@1|root,COG0535@2|Bacteria,1ZT6Q@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
SHD1_k127_3044655_17	861299.J421_2676	9.139e-15	81.0	2FDPQ@1|root,345QV@2|Bacteria,1ZU3Q@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_3044655_9	861299.J421_2675	8.02e-89	302.0	2ED0A@1|root,336X9@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_3044655_12	661478.OP10G_2288	6.151e-73	266.0	COG2234@1|root,COG2234@2|Bacteria	2|Bacteria	DZ	aminopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,PA,Peptidase_M28
SHD1_k127_3044655_11	861299.J421_2674	5.686e-77	274.0	COG0463@1|root,COG0463@2|Bacteria,1ZTJE@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	Glycosyl transferase family 2	-	-	-	ko:K08301	-	-	-	-	ko00000,ko01000,ko03009,ko03019	-	-	-	Glycos_transf_2
SHD1_k127_3044655_14	861299.J421_1980	1.68e-59	223.0	COG3170@1|root,COG3170@2|Bacteria,1ZTDF@142182|Gemmatimonadetes	2|Bacteria	NU	Protein of unknown function (DUF3108)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3108
SHD1_k127_3044655_5	861299.J421_2672	7.414e-138	446.0	COG1899@1|root,COG1899@2|Bacteria	2|Bacteria	O	peptidyl-lysine modification to peptidyl-hypusine	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_3044655_16	861299.J421_2670	1.038e-18	88.0	296V5@1|root,2ZU41@2|Bacteria,1ZU78@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_3044655_15	391612.CY0110_30643	2.867e-50	197.0	COG0665@1|root,COG2022@1|root,COG0665@2|Bacteria,COG2022@2|Bacteria,1FZYU@1117|Cyanobacteria,3KGAR@43988|Cyanothece	1117|Cyanobacteria	H	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S	thiG	-	2.8.1.10	ko:K03149	ko00730,ko01100,map00730,map01100	-	R10247	RC03096,RC03097,RC03461	ko00000,ko00001,ko01000	-	-	-	DAO,ThiG
SHD1_k127_3044655_3	1379270.AUXF01000004_gene3127	1.858e-157	502.0	COG0320@1|root,COG0320@2|Bacteria,1ZTA3@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	-	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
SHD1_k127_3044655_4	861299.J421_2668	4.398e-153	492.0	COG1071@1|root,COG1071@2|Bacteria,1ZT5G@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	pdhA	-	1.2.4.1	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
SHD1_k127_3044655_2	1379270.AUXF01000004_gene3129	5.3e-180	567.0	COG0022@1|root,COG0022@2|Bacteria,1ZTA8@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Transketolase, pyrimidine binding domain	-	-	1.2.4.1	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
SHD1_k127_3044655_7	1089547.KB913013_gene1047	6.852e-101	345.0	COG0508@1|root,COG0508@2|Bacteria,4NFB9@976|Bacteroidetes,47KP4@768503|Cytophagia	976|Bacteroidetes	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	pdhC	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
SHD1_k127_3044655_1	861299.J421_2662	2.211e-210	668.0	COG1249@1|root,COG1249@2|Bacteria,1ZT95@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
SHD1_k127_3044655_10	861299.J421_2661	1.765e-79	272.0	COG0321@1|root,COG0321@2|Bacteria,1ZTM1@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate	lipB	-	2.3.1.181	ko:K03801	ko00785,ko01100,map00785,map01100	-	R07766,R07769	RC00039,RC00992,RC02867	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
SHD1_k127_3044655_13	1163407.UU7_04737	4.102e-71	257.0	COG1834@1|root,COG1834@2|Bacteria,1MZ9U@1224|Proteobacteria,1RN0M@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Amidinotransferase	-	-	3.5.3.18	ko:K01482	-	-	-	-	ko00000,ko01000,ko04147	-	-	-	Amidinotransf
SHD1_k127_3044655_0	861299.J421_2660	4.694e-283	884.0	COG0210@1|root,COG0210@2|Bacteria,1ZSMM@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	UvrD-like helicase C-terminal domain	-	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
SHD1_k127_3044655_6	861299.J421_2658	1.212e-103	349.0	COG4324@1|root,COG4324@2|Bacteria,1ZT8G@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Putative aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Aminopep
SHD1_k127_3044655_8	861299.J421_2657	4.599e-94	323.0	COG5492@1|root,COG5492@2|Bacteria,1ZSW8@142182|Gemmatimonadetes	2|Bacteria	N	domain, Protein	-	-	3.2.1.4,3.4.17.14	ko:K01179,ko:K07260,ko:K13735	ko00500,ko00550,ko01100,ko01502,ko02020,ko05100,map00500,map00550,map01100,map01502,map02020,map05100	M00651	R06200,R11307,R11308	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504	-	GH5,GH9	-	Big_1,Big_2,Glug,IAT_beta,Invasin_D3,LysM,Mfa_like_1,SLH
SHD1_k127_3054255_7	379066.GAU_0848	9.95e-24	100.0	COG0267@1|root,COG0267@2|Bacteria,1ZV8A@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Ribosomal protein L33	-	-	-	ko:K02913	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L33
SHD1_k127_3054255_8	1122947.FR7_0039	4.514e-06	51.0	COG0690@1|root,COG0690@2|Bacteria,1VK48@1239|Firmicutes,4H5Y7@909932|Negativicutes	909932|Negativicutes	U	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation	secE	-	-	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecE
SHD1_k127_3054255_3	861299.J421_2762	3.659e-87	295.0	COG0250@1|root,COG0250@2|Bacteria,1ZSS2@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Participates in transcription elongation, termination and antitermination	nusG	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusG
SHD1_k127_3054255_5	1499684.CCNP01000014_gene309	7.169e-61	214.0	COG0080@1|root,COG0080@2|Bacteria,1V1BS@1239|Firmicutes,24FSQ@186801|Clostridia,36I00@31979|Clostridiaceae	186801|Clostridia	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rplK	-	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
SHD1_k127_3054255_1	861299.J421_2764	1.357e-114	372.0	COG0081@1|root,COG0081@2|Bacteria,1ZSS7@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	-	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
SHD1_k127_3054255_4	861299.J421_2765	9.449e-72	245.0	COG0244@1|root,COG0244@2|Bacteria,1ZTQI@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rplJ	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
SHD1_k127_3054255_6	861299.J421_2766	9.875e-54	191.0	COG0222@1|root,COG0222@2|Bacteria,1ZTTC@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation	rplL	-	-	ko:K02935	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L12,Ribosomal_L12_N
SHD1_k127_3054255_0	861299.J421_2767	0.0	2470.0	COG0085@1|root,COG0085@2|Bacteria,1ZSQH@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
SHD1_k127_3054255_2	1379270.AUXF01000004_gene3046	1.605e-101	330.0	COG0086@1|root,COG0303@1|root,COG0086@2|Bacteria,COG0303@2|Bacteria,1ZSZQ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
SHD1_k127_3067486_1	1379270.AUXF01000005_gene377	1.049e-28	118.0	COG0469@1|root,COG0469@2|Bacteria,1ZSMD@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	Pyruvate kinase, barrel domain	-	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
SHD1_k127_3067486_0	861299.J421_2867	5.622e-143	470.0	COG0176@1|root,COG0176@2|Bacteria,1ZSZV@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
SHD1_k127_3067486_3	1469607.KK073768_gene2983	2.84e-06	54.0	2DQ7S@1|root,3355J@2|Bacteria,1GA7T@1117|Cyanobacteria,1HPJ8@1161|Nostocales	1117|Cyanobacteria	S	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core3
SHD1_k127_3067486_2	1111479.AXAR01000003_gene1512	4.506e-15	84.0	COG4454@1|root,COG4454@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1,SoxE
SHD1_k127_3069760_1	1379270.AUXF01000002_gene1838	8.487e-212	665.0	COG0495@1|root,COG0495@2|Bacteria,1ZSXC@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Leucyl-tRNA synthetase, Domain 2	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
SHD1_k127_3069760_2	666685.R2APBS1_3299	1.69e-152	502.0	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,1RPIW@1236|Gammaproteobacteria,1X593@135614|Xanthomonadales	135614|Xanthomonadales	Q	Amidohydrolase family	-	-	3.5.1.81	ko:K06015	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Amidohydro_3
SHD1_k127_3069760_3	945713.IALB_0512	3.41e-112	373.0	COG1814@1|root,COG1814@2|Bacteria	2|Bacteria	S	cellular manganese ion homeostasis	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin,VIT1
SHD1_k127_3069760_4	1095769.CAHF01000003_gene1049	2.276e-08	66.0	COG2067@1|root,COG2067@2|Bacteria,1N1F4@1224|Proteobacteria,2VW9Z@28216|Betaproteobacteria,4762T@75682|Oxalobacteraceae	28216|Betaproteobacteria	I	Putative MetA-pathway of phenol degradation	-	-	-	-	-	-	-	-	-	-	-	-	Phenol_MetA_deg
SHD1_k127_3069760_0	861299.J421_2427	1.252e-253	797.0	COG3158@1|root,COG3158@2|Bacteria,1ZTCK@142182|Gemmatimonadetes	142182|Gemmatimonadetes	P	Transport of potassium into the cell	kup	-	-	ko:K03549	-	-	-	-	ko00000,ko02000	2.A.72	-	-	K_trans
SHD1_k127_307215_1	861299.J421_1760	1.479e-150	496.0	COG0515@1|root,COG0515@2|Bacteria,1ZUFG@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
SHD1_k127_307215_2	1183438.GKIL_3505	1.719e-148	493.0	COG1506@1|root,COG1506@2|Bacteria,1G1Q1@1117|Cyanobacteria	1117|Cyanobacteria	EU	PFAM Prolyl oligopeptidase family	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
SHD1_k127_307215_4	1379270.AUXF01000001_gene2600	6.772e-06	52.0	29FC1@1|root,3029Q@2|Bacteria,1ZV83@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_307215_0	861299.J421_3766	0.0	1479.0	COG3696@1|root,COG3696@2|Bacteria,1ZUB0@142182|Gemmatimonadetes	142182|Gemmatimonadetes	P	AcrB/AcrD/AcrF family	-	-	-	ko:K15726	-	-	-	-	ko00000,ko02000	2.A.6.1.2	-	-	ACR_tran
SHD1_k127_307215_3	666685.R2APBS1_3419	5.46e-06	48.0	COG0845@1|root,COG0845@2|Bacteria,1MVAS@1224|Proteobacteria,1RWJY@1236|Gammaproteobacteria,1X3Z5@135614|Xanthomonadales	135614|Xanthomonadales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K15727	-	-	-	-	ko00000,ko02000	8.A.1.2.1	-	-	HlyD_D23
SHD1_k127_3089303_5	861299.J421_3939	4.056e-13	73.0	COG2879@1|root,COG2879@2|Bacteria,1ZU6T@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Selenoprotein, putative	-	-	-	-	-	-	-	-	-	-	-	-	Sel_put
SHD1_k127_3089303_0	1379270.AUXF01000003_gene3439	1.039e-266	844.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1ZSNX@142182|Gemmatimonadetes	142182|Gemmatimonadetes	EU	Dipeptidyl peptidase IV (DPP IV) N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	DPPIV_N,PD40,Peptidase_S9
SHD1_k127_3089303_4	429009.Adeg_0104	1.632e-24	119.0	COG0438@1|root,COG0438@2|Bacteria,1UHSF@1239|Firmicutes,25EAY@186801|Clostridia,42G5D@68295|Thermoanaerobacterales	186801|Clostridia	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
SHD1_k127_3089303_3	702113.PP1Y_AT8041	4.161e-42	174.0	COG0451@1|root,COG0451@2|Bacteria,1MW32@1224|Proteobacteria,2TTTU@28211|Alphaproteobacteria,2K23Q@204457|Sphingomonadales	204457|Sphingomonadales	M	NAD-dependent epimerase dehydratase	-	-	1.1.1.219	ko:K00091	-	-	-	-	ko00000,ko01000	-	-	-	Epimerase
SHD1_k127_3089303_1	997346.HMPREF9374_0159	2.707e-261	823.0	COG1966@1|root,COG1966@2|Bacteria,1TQN8@1239|Firmicutes,4H9SU@91061|Bacilli,27BJQ@186824|Thermoactinomycetaceae	91061|Bacilli	T	5TM C-terminal transporter carbon starvation CstA	cstA	-	-	ko:K06200	-	-	-	-	ko00000	-	-	-	CstA,CstA_5TM
SHD1_k127_3089303_2	1379270.AUXF01000003_gene3443	4.925e-141	462.0	COG0473@1|root,COG0473@2|Bacteria,1ZTDX@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Isocitrate/isopropylmalate dehydrogenase	-	-	1.1.1.41	ko:K00030	ko00020,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010	R00709	RC00114	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
SHD1_k127_3099627_3	448385.sce4395	4.34e-37	150.0	COG2515@1|root,COG2515@2|Bacteria,1MVYF@1224|Proteobacteria,42PWI@68525|delta/epsilon subdivisions,2WPU4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Pyridoxal-phosphate dependent enzyme	-	-	4.4.1.15	ko:K05396	ko00270,map00270	-	R01874	RC00382	ko00000,ko00001,ko01000	-	-	-	PALP
SHD1_k127_3099627_2	378806.STAUR_4296	6.655e-42	158.0	COG0745@1|root,COG0745@2|Bacteria,1P6A4@1224|Proteobacteria,4333R@68525|delta/epsilon subdivisions,2WY7A@28221|Deltaproteobacteria	28221|Deltaproteobacteria	KT	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
SHD1_k127_3099627_0	378806.STAUR_4295	1.104e-99	343.0	COG0467@1|root,COG0467@2|Bacteria,1NEWW@1224|Proteobacteria,42YYA@68525|delta/epsilon subdivisions,2WTU4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	KaiC	-	-	-	ko:K08482	-	-	-	-	ko00000	-	-	-	ATPase
SHD1_k127_3099627_1	861299.J421_1044	8.442e-75	268.0	COG0642@1|root,COG2205@2|Bacteria	861299.J421_1044|-	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_3105130_1	861299.J421_2643	1.037e-59	218.0	COG1512@1|root,COG1512@2|Bacteria,1ZT1H@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	TPM domain	-	-	-	ko:K06872	-	-	-	-	ko00000	-	-	-	TPM_phosphatase
SHD1_k127_3105130_0	861299.J421_2644	5.582e-85	287.0	COG1708@1|root,COG1708@2|Bacteria,1ZTN5@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	nucleotidyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_3105130_2	1379270.AUXF01000004_gene3149	1.835e-49	181.0	COG1704@1|root,COG1704@2|Bacteria,1ZTQE@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	LemA family	-	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
SHD1_k127_3111342_4	688245.CtCNB1_3056	1.919e-06	51.0	COG0605@1|root,COG0605@2|Bacteria,1MV24@1224|Proteobacteria,2VK7A@28216|Betaproteobacteria,4ACJQ@80864|Comamonadaceae	28216|Betaproteobacteria	C	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	sodA	-	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
SHD1_k127_3111342_2	1379270.AUXF01000003_gene3811	3.233e-74	259.0	COG0586@1|root,COG0586@2|Bacteria,1ZTJB@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	SNARE associated Golgi protein	-	-	-	ko:K03975	-	-	-	-	ko00000	-	-	-	SNARE_assoc
SHD1_k127_3111342_1	861299.J421_0728	9.133e-94	315.0	COG3315@1|root,COG3315@2|Bacteria	2|Bacteria	Q	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	LCM
SHD1_k127_3111342_0	861299.J421_3641	5.487e-132	431.0	COG0383@1|root,COG0383@2|Bacteria,1ZT4Q@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	Alpha mannosidase, middle domain	-	-	3.2.1.24	ko:K01191	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04131	-	GH38	-	Alpha-mann_mid,Glyco_hydro_38
SHD1_k127_3117585_5	1173025.GEI7407_3781	6.098e-23	111.0	COG2936@1|root,COG2936@2|Bacteria,1G1U8@1117|Cyanobacteria,1H7W3@1150|Oscillatoriales	1117|Cyanobacteria	S	Hydrolase CocE NonD family	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
SHD1_k127_3117585_3	1121377.KB906402_gene3279	5.389e-104	343.0	COG1402@1|root,COG1402@2|Bacteria	2|Bacteria	I	creatininase	crnA_1	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
SHD1_k127_3117585_0	1121377.KB906402_gene3278	5.809e-123	413.0	COG1893@1|root,COG1893@2|Bacteria	2|Bacteria	H	2-dehydropantoate 2-reductase activity	-	-	1.1.1.169,3.4.17.11	ko:K00077,ko:K01295	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	ApbA,ApbA_C,M20_dimer,Peptidase_M20
SHD1_k127_3117585_1	1121381.JNIV01000063_gene4276	7.666e-112	370.0	COG1028@1|root,COG1028@2|Bacteria,1WJEE@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	IQ	KR domain	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
SHD1_k127_3117585_2	1121377.KB906402_gene3276	3.831e-106	356.0	COG0624@1|root,COG0624@2|Bacteria,1WMF4@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
SHD1_k127_3117585_4	926550.CLDAP_09090	4.849e-29	121.0	COG0624@1|root,COG0624@2|Bacteria,2G62C@200795|Chloroflexi	200795|Chloroflexi	E	Peptidase dimerisation domain protein	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
SHD1_k127_3120723_0	861299.J421_6226	3.638e-89	314.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
SHD1_k127_3120723_1	861299.J421_2746	5.375e-45	179.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
SHD1_k127_3120723_2	861299.J421_0639	2.158e-31	126.0	COG1695@1|root,COG1695@2|Bacteria	2|Bacteria	K	negative regulation of transcription, DNA-templated	-	-	-	-	-	-	-	-	-	-	-	-	PadR
SHD1_k127_3120723_3	1379270.AUXF01000003_gene3421	4.433e-25	115.0	2C0MY@1|root,30KW5@2|Bacteria,1ZTVN@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_3120723_4	1123248.KB893317_gene4264	7.201e-20	95.0	COG1228@1|root,COG1228@2|Bacteria,4NKV0@976|Bacteroidetes	976|Bacteroidetes	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
SHD1_k127_3130206_9	1379270.AUXF01000006_gene312	3.319e-92	307.0	COG2199@1|root,COG2199@2|Bacteria,1ZT1F@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	Diguanylate cyclase, GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
SHD1_k127_3130206_12	861299.J421_3210	1.609e-52	196.0	2F3JX@1|root,33WDB@2|Bacteria,1ZTZI@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	zinc_ribbon_4
SHD1_k127_3130206_5	861299.J421_3211	1.31e-144	469.0	COG1186@1|root,COG1186@2|Bacteria,1ZTE4@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
SHD1_k127_3130206_2	861299.J421_3212	1.964e-222	706.0	COG1190@1|root,COG1190@2|Bacteria,1ZT9X@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	tRNA synthetases class II (D, K and N)	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
SHD1_k127_3130206_6	379066.GAU_1580	2.968e-143	466.0	COG4591@1|root,COG4591@2|Bacteria,1ZT1N@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	MacB-like periplasmic core domain	-	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
SHD1_k127_3130206_10	861299.J421_3214	6.154e-91	314.0	COG1136@1|root,COG1136@2|Bacteria,1ZSNF@142182|Gemmatimonadetes	142182|Gemmatimonadetes	V	Part of the ABC transporter complex LolCDE involved in the translocation of	lolD	-	-	ko:K09810	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.125	-	-	ABC_tran
SHD1_k127_3130206_11	861299.J421_3215	5.511e-53	191.0	COG3880@1|root,COG3880@2|Bacteria,1ZTPQ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	UvrB/uvrC motif	-	-	-	ko:K19411	-	-	-	-	ko00000	-	-	-	UVR
SHD1_k127_3130206_3	1379270.AUXF01000006_gene305	2.487e-170	545.0	COG3869@1|root,COG3869@2|Bacteria,1ZT9I@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	ATP:guanido phosphotransferase, C-terminal catalytic domain	-	-	2.7.14.1	ko:K19405	-	-	R11090	RC00002,RC00203	ko00000,ko01000	-	-	-	ATP-gua_Ptrans
SHD1_k127_3130206_0	986075.CathTA2_0959	1.342e-311	975.0	COG0542@1|root,COG0542@2|Bacteria,1TPMU@1239|Firmicutes,4HACY@91061|Bacilli	91061|Bacilli	O	Belongs to the ClpA ClpB family	clpC	GO:0006950,GO:0008150,GO:0010035,GO:0010038,GO:0042221,GO:0046686,GO:0046688,GO:0050896,GO:0097501,GO:1990169,GO:1990170	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
SHD1_k127_3130206_1	861299.J421_3218	5.377e-288	905.0	COG4775@1|root,COG4775@2|Bacteria,1ZT6B@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	Surface antigen	-	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
SHD1_k127_3130206_13	379066.GAU_1586	5.081e-29	131.0	COG2825@1|root,COG2825@2|Bacteria,1ZU5E@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	Outer membrane protein (OmpH-like)	-	-	-	ko:K06142	-	-	-	-	ko00000	-	-	-	OmpH
SHD1_k127_3130206_8	861299.J421_3220	8.506e-99	345.0	COG1044@1|root,COG1044@2|Bacteria,1ZSRF@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxD	-	2.3.1.191	ko:K02536	ko00540,ko01100,map00540,map01100	M00060	R04550	RC00039,RC00166	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hexapep,LpxD
SHD1_k127_3130206_4	379066.GAU_1588	3.387e-163	524.0	COG0764@1|root,COG0774@1|root,COG0764@2|Bacteria,COG0774@2|Bacteria,1ZT4Z@142182|Gemmatimonadetes	142182|Gemmatimonadetes	IM	Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis	fabZ	-	3.5.1.108,4.2.1.59	ko:K16363	ko00061,ko00540,ko01100,ko01212,map00061,map00540,map01100,map01212	M00060,M00083	R04428,R04535,R04537,R04544,R04568,R04587,R04954,R04965	RC00166,RC00300,RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004,ko01005	-	-	-	FabA,LpxC
SHD1_k127_3130206_7	379066.GAU_1589	1.418e-102	340.0	COG1043@1|root,COG1043@2|Bacteria,1ZT7T@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	-	-	2.3.1.129	ko:K00677	ko00540,ko01100,ko01503,map00540,map01100,map01503	M00060	R04567	RC00039,RC00055	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Acetyltransf_11,Hexapep
SHD1_k127_3137158_1	42256.RradSPS_2139	5.658e-69	240.0	COG0667@1|root,COG0667@2|Bacteria,2GJBG@201174|Actinobacteria,4CPGS@84995|Rubrobacteria	84995|Rubrobacteria	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
SHD1_k127_3137158_0	861299.J421_4188	5.369e-85	284.0	COG0221@1|root,COG0221@2|Bacteria,1ZTH9@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions	ppa	-	3.6.1.1	ko:K01507	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyrophosphatase
SHD1_k127_3137158_2	1125863.JAFN01000001_gene1090	4.195e-58	215.0	COG0618@1|root,COG0618@2|Bacteria,1N0JS@1224|Proteobacteria,42P1S@68525|delta/epsilon subdivisions,2WJV0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM phosphoesterase, RecJ domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DHH,DHHA1
SHD1_k127_3144618_0	861299.J421_3398	3.275e-165	521.0	COG1077@1|root,COG1077@2|Bacteria,1ZT9B@142182|Gemmatimonadetes	142182|Gemmatimonadetes	D	Hsp70 protein	-	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
SHD1_k127_3144618_2	1121440.AUMA01000005_gene2633	3.321e-10	64.0	COG1148@1|root,COG1578@1|root,COG1148@2|Bacteria,COG1578@2|Bacteria,1RI11@1224|Proteobacteria,42RA1@68525|delta/epsilon subdivisions,2WMCD@28221|Deltaproteobacteria,2MBST@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Protein of unknown function DUF89	-	-	-	ko:K09116	-	-	-	-	ko00000	-	-	-	DUF89
SHD1_k127_3144618_1	945713.IALB_0329	1.086e-94	324.0	COG0644@1|root,COG0644@2|Bacteria	2|Bacteria	C	geranylgeranyl reductase activity	-	-	1.3.1.101,1.3.1.111,1.3.1.83,1.3.7.11	ko:K10960,ko:K17830	ko00564,ko00860,ko00900,ko01100,ko01110,map00564,map00860,map00900,map01100,map01110	-	R02063,R08754,R08755,R08756,R10325,R10326,R10331,R11226,R11518	RC00212,RC00522,RC01823,RC03134	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3
SHD1_k127_3149905_6	1125863.JAFN01000001_gene969	6.16e-55	199.0	COG0264@1|root,COG0264@2|Bacteria,1MUS2@1224|Proteobacteria,42NNS@68525|delta/epsilon subdivisions,2WMS3@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
SHD1_k127_3149905_2	861299.J421_3412	3.042e-134	435.0	COG0052@1|root,COG0052@2|Bacteria,1ZSNR@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Ribosomal protein S2	rpsB	-	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
SHD1_k127_3149905_5	861299.J421_3413	2.411e-57	207.0	COG0103@1|root,COG0103@2|Bacteria,1ZTM0@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Ribosomal protein S9/S16	rpsI	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
SHD1_k127_3149905_4	1379270.AUXF01000006_gene117	3.476e-71	243.0	COG0102@1|root,COG0102@2|Bacteria,1ZTIS@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	-	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
SHD1_k127_3149905_7	1379270.AUXF01000006_gene115	1.244e-43	173.0	COG4770@1|root,COG4770@2|Bacteria,1ZTVQ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Biotin-requiring enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl
SHD1_k127_3149905_3	861299.J421_3416	7.751e-132	432.0	COG2265@1|root,COG2265@2|Bacteria,1ZSPC@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	tRNA (Uracil-5-)-methyltransferase	-	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	tRNA_U5-meth_tr
SHD1_k127_3149905_1	861299.J421_3417	4.678e-210	666.0	COG0439@1|root,COG0439@2|Bacteria,1ZTBD@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Biotin carboxylase C-terminal domain	-	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
SHD1_k127_3149905_8	1121121.KB894308_gene199	1.598e-19	97.0	COG1225@1|root,COG1225@2|Bacteria,1VP1K@1239|Firmicutes,4HRU3@91061|Bacilli,272P5@186822|Paenibacillaceae	91061|Bacilli	O	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
SHD1_k127_3149905_0	861299.J421_3418	1.533e-270	836.0	COG4799@1|root,COG4799@2|Bacteria,1ZTGE@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Carboxyl transferase domain	-	-	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
SHD1_k127_3161402_1	504472.Slin_5486	2.89e-77	262.0	COG0652@1|root,COG0652@2|Bacteria,4NMG5@976|Bacteroidetes,47PB6@768503|Cytophagia	976|Bacteroidetes	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	-	-	5.2.1.8	ko:K03768	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Pro_isomerase
SHD1_k127_3161402_0	861299.J421_1336	1.251e-137	443.0	COG0596@1|root,COG0596@2|Bacteria,1ZUIK@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Serine aminopeptidase, S33	-	-	-	ko:K19707	-	-	-	-	ko00000,ko03021	-	-	-	Abhydrolase_6
SHD1_k127_3193542_3	1170562.Cal6303_2806	5.532e-09	59.0	2CDHC@1|root,30QNS@2|Bacteria,1GBGU@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_3193542_1	366602.Caul_4399	2.488e-41	156.0	COG1765@1|root,COG1765@2|Bacteria,1RIBQ@1224|Proteobacteria,2U9TC@28211|Alphaproteobacteria,2KISN@204458|Caulobacterales	204458|Caulobacterales	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
SHD1_k127_3193542_2	235985.BBPN01000008_gene3951	3.867e-24	110.0	2BFUD@1|root,329PJ@2|Bacteria,2IMNG@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_3193542_0	391612.CY0110_13831	4.907e-49	186.0	COG0515@1|root,COG0515@2|Bacteria,1G08U@1117|Cyanobacteria,3KH6Q@43988|Cyanothece	1117|Cyanobacteria	KLT	Serine Threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,TPR_1,TPR_2,TPR_8
SHD1_k127_3193909_1	234267.Acid_4623	2.735e-115	381.0	COG4447@1|root,COG4447@2|Bacteria,3Y2SN@57723|Acidobacteria	57723|Acidobacteria	S	Sortilin, neurotensin receptor 3,	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
SHD1_k127_3193909_2	861299.J421_2198	2.36e-47	172.0	COG1695@1|root,COG1695@2|Bacteria	2|Bacteria	K	negative regulation of transcription, DNA-templated	-	-	-	-	-	-	-	-	-	-	-	-	PadR
SHD1_k127_3193909_0	861299.J421_1366	9.086e-245	791.0	COG0577@1|root,COG0577@2|Bacteria,1ZUNA@142182|Gemmatimonadetes	142182|Gemmatimonadetes	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
SHD1_k127_3193909_3	278963.ATWD01000001_gene4018	1.077e-44	172.0	COG2930@1|root,COG2930@2|Bacteria,3Y2F0@57723|Acidobacteria,2JIT6@204432|Acidobacteriia	204432|Acidobacteriia	S	Las17-binding protein actin regulator	-	-	-	-	-	-	-	-	-	-	-	-	Ysc84
SHD1_k127_3198428_1	1267533.KB906739_gene2672	8.978e-28	119.0	COG0581@1|root,COG0581@2|Bacteria,3Y3JF@57723|Acidobacteria,2JHVP@204432|Acidobacteriia	204432|Acidobacteriia	P	Phosphate transport system permease protein PstA	-	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
SHD1_k127_3198428_0	204669.Acid345_2974	2.151e-109	366.0	COG0573@1|root,COG0573@2|Bacteria,3Y42Y@57723|Acidobacteria,2JIJN@204432|Acidobacteriia	204432|Acidobacteriia	P	probably responsible for the translocation of the substrate across the membrane	-	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
SHD1_k127_3198428_2	1217714.F975_02678	3.569e-05	48.0	COG0226@1|root,COG0226@2|Bacteria,1MUAZ@1224|Proteobacteria,1RN5Q@1236|Gammaproteobacteria,3NN0Y@468|Moraxellaceae	1236|Gammaproteobacteria	P	Part of the ABC transporter complex PstSACB involved in phosphate import	pstS	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0006950,GO:0006974,GO:0008150,GO:0009314,GO:0009628,GO:0009987,GO:0010921,GO:0015698,GO:0019220,GO:0019222,GO:0030288,GO:0030313,GO:0031323,GO:0031975,GO:0033554,GO:0035303,GO:0042301,GO:0042597,GO:0043167,GO:0043168,GO:0044464,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051174,GO:0051179,GO:0051234,GO:0051336,GO:0051716,GO:0065007,GO:0065009	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	iECH74115_1262.ECH74115_5157,iECSP_1301.ECSP_4770,iECs_1301.ECs4664,iG2583_1286.G2583_4518,iJN746.PP_2656,iZ_1308.Z5219	PBP_like_2
SHD1_k127_3229173_0	204669.Acid345_2836	1.362e-134	436.0	COG1262@1|root,COG1262@2|Bacteria,3Y3U7@57723|Acidobacteria,2JI33@204432|Acidobacteriia	204432|Acidobacteriia	S	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2,FGE-sulfatase
SHD1_k127_3229173_1	1131814.JAFO01000001_gene2783	1.404e-97	329.0	COG4301@1|root,COG4301@2|Bacteria,1MUCG@1224|Proteobacteria,2TRMH@28211|Alphaproteobacteria,3F15K@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	Histidine-specific methyltransferase, SAM-dependent	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_33
SHD1_k127_3229173_2	1265313.HRUBRA_02839	3.728e-63	228.0	COG1174@1|root,COG1732@1|root,COG1174@2|Bacteria,COG1732@2|Bacteria,1MV9N@1224|Proteobacteria,1RPSP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Glycine betaine	opuCC	-	-	ko:K05845	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	OpuAC
SHD1_k127_3243129_1	861299.J421_3283	1.533e-109	364.0	COG1008@1|root,COG1008@2|Bacteria,1ZUBB@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Proton-conducting membrane transporter	-	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
SHD1_k127_3243129_0	861299.J421_3284	1.881e-254	799.0	COG1009@1|root,COG1009@2|Bacteria,1ZSZY@142182|Gemmatimonadetes	142182|Gemmatimonadetes	CP	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus	-	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
SHD1_k127_3257857_3	861299.J421_3104	4.07e-139	452.0	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,1ZSMY@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Competence protein	-	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,Lactamase_B
SHD1_k127_3257857_2	861299.J421_3106	3.47e-178	562.0	COG0158@1|root,COG0158@2|Bacteria,1ZTAZ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	Fructose-1-6-bisphosphatase, N-terminal domain	fbp	-	3.1.3.11	ko:K03841	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko04152,ko04910,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map04152,map04910	M00003,M00165,M00167,M00344	R00762,R04780	RC00017	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	FBPase
SHD1_k127_3257857_0	861299.J421_3107	2.794e-249	779.0	COG1884@1|root,COG1884@2|Bacteria,1ZT5I@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
SHD1_k127_3257857_4	485913.Krac_5322	9.263e-51	188.0	COG2320@1|root,COG2320@2|Bacteria	2|Bacteria	Q	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	-	-	-	-	-	-	-	-	-	-	-	-	GrpB,Methyltransf_11
SHD1_k127_3257857_5	861299.J421_3109	3.167e-18	90.0	COG2331@1|root,COG2331@2|Bacteria,1ZU2W@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Regulatory protein, FmdB family	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_3257857_1	379066.GAU_1467	1.105e-180	581.0	COG0018@1|root,COG0018@2|Bacteria,1ZT6E@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Arginyl tRNA synthetase N terminal dom	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
SHD1_k127_3271266_0	861299.J421_2927	7.438e-174	553.0	COG0621@1|root,COG0621@2|Bacteria,1ZT70@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12	rimO	-	2.8.4.4	ko:K14441	-	-	R10652	RC00003,RC03217	ko00000,ko01000,ko03009	-	-	-	Radical_SAM,UPF0004
SHD1_k127_3271266_1	379066.GAU_1175	5.983e-105	353.0	COG0001@1|root,COG0001@2|Bacteria,1ZSYC@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Aminotransferase class-III	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
SHD1_k127_3273866_1	1379270.AUXF01000002_gene1165	1.272e-11	72.0	COG1729@1|root,COG3087@1|root,COG1729@2|Bacteria,COG3087@2|Bacteria,1ZTSZ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	D	Sporulation related domain	-	-	-	-	-	-	-	-	-	-	-	-	SPOR,TPR_6
SHD1_k127_3273866_0	886293.Sinac_6584	4.276e-243	784.0	COG0249@1|root,COG0249@2|Bacteria,2IXGV@203682|Planctomycetes	203682|Planctomycetes	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
SHD1_k127_327621_0	861299.J421_0339	8.23e-155	500.0	COG2303@1|root,COG2303@2|Bacteria	2|Bacteria	E	choline dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N
SHD1_k127_327621_6	1158292.JPOE01000002_gene1511	5.496e-39	151.0	COG3238@1|root,COG3238@2|Bacteria,1N6ZC@1224|Proteobacteria,2VVA0@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Putative inner membrane exporter, YdcZ	-	-	-	ko:K09936	ko02024,map02024	-	-	-	ko00000,ko00001,ko02000	2.A.7.21	-	-	DMT_YdcZ
SHD1_k127_327621_3	861299.J421_6231	1.204e-62	231.0	COG0491@1|root,COG0491@2|Bacteria,1ZU73@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
SHD1_k127_327621_4	1215114.BBIU01000009_gene1496	4.281e-51	193.0	COG2207@1|root,COG2207@2|Bacteria,1QKC9@1224|Proteobacteria,1RMG3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,HTH_18
SHD1_k127_327621_7	391038.Bphy_3722	1.846e-37	149.0	2DBDP@1|root,32TXA@2|Bacteria,1NRJC@1224|Proteobacteria,2W125@28216|Betaproteobacteria,1K3D5@119060|Burkholderiaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_327621_5	479434.Sthe_0370	3.261e-50	183.0	2DW90@1|root,33Z49@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1706)	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_327621_1	1396418.BATQ01000141_gene3316	2.297e-102	341.0	COG0122@1|root,COG2169@1|root,COG0122@2|Bacteria,COG2169@2|Bacteria,46T20@74201|Verrucomicrobia,2IV2R@203494|Verrucomicrobiae	203494|Verrucomicrobiae	L	AlkA N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Ada_Zn_binding,AlkA_N,HTH_18,HhH-GPD
SHD1_k127_327621_2	1267535.KB906767_gene245	1.165e-77	265.0	COG2318@1|root,COG2318@2|Bacteria	2|Bacteria	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB
SHD1_k127_3287380_4	861299.J421_3204	2.349e-56	213.0	COG0127@1|root,COG0127@2|Bacteria,1ZTSC@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Ham1 family	-	-	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
SHD1_k127_3287380_0	379066.GAU_1571	8.311e-103	340.0	COG0689@1|root,COG0689@2|Bacteria,1ZSYT@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates	rph	-	2.7.7.56	ko:K00989	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNase_PH,RNase_PH_C
SHD1_k127_3287380_3	861299.J421_3202	6.171e-59	211.0	COG0615@1|root,COG0615@2|Bacteria,1ZTPI@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose	-	-	-	-	-	-	-	-	-	-	-	-	CTP_transf_like
SHD1_k127_3287380_7	861299.J421_3201	2.884e-51	188.0	2EPTK@1|root,33HE4@2|Bacteria,1ZTUK@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Lipopolysaccharide-assembly	-	-	-	-	-	-	-	-	-	-	-	-	LptE
SHD1_k127_3287380_5	861299.J421_3200	4.029e-55	201.0	2F5A9@1|root,33XWF@2|Bacteria,1ZTU9@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_3287380_2	1379270.AUXF01000005_gene834	9.262e-90	322.0	COG0652@1|root,COG0652@2|Bacteria,1ZUUW@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	-	-	5.2.1.8	ko:K03768	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Pro_isomerase
SHD1_k127_3287380_8	861299.J421_3199	2.825e-41	156.0	COG0824@1|root,COG0824@2|Bacteria,1ZTY3@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Thioesterase-like superfamily	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT
SHD1_k127_3287380_1	861299.J421_3198	2.989e-94	315.0	COG2908@1|root,COG2908@2|Bacteria,1ZTNP@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Calcineurin-like phosphoesterase	-	-	3.6.1.54	ko:K03269	ko00540,ko01100,map00540,map01100	M00060	R04549	RC00002	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Metallophos
SHD1_k127_3287380_6	521098.Aaci_1848	3.695e-52	192.0	COG0796@1|root,COG0796@2|Bacteria,1TPPR@1239|Firmicutes,4HA46@91061|Bacilli,27A31@186823|Alicyclobacillaceae	91061|Bacilli	M	Provides the (R)-glutamate required for cell wall biosynthesis	murI	GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008881,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016853,GO:0016854,GO:0016855,GO:0030203,GO:0034645,GO:0036361,GO:0042546,GO:0042802,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0047661,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	3.6.1.66,5.1.1.3	ko:K01776,ko:K02428	ko00230,ko00471,ko01100,map00230,map00471,map01100	-	R00260,R00426,R00720,R01855,R02100,R02720,R03531	RC00002,RC00302	ko00000,ko00001,ko01000,ko01011	-	-	-	Asp_Glu_race
SHD1_k127_3292120_3	204669.Acid345_4575	5.093e-44	166.0	COG0842@1|root,COG1511@1|root,COG0842@2|Bacteria,COG1511@2|Bacteria,3Y65Z@57723|Acidobacteria,2JM5S@204432|Acidobacteriia	204432|Acidobacteriia	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
SHD1_k127_3292120_1	204669.Acid345_4576	4.868e-125	411.0	COG1131@1|root,COG1131@2|Bacteria,3Y3PY@57723|Acidobacteria,2JIQU@204432|Acidobacteriia	204432|Acidobacteriia	V	pfam abc	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SHD1_k127_3292120_5	484770.UFO1_4397	1.36e-21	107.0	COG1566@1|root,COG1566@2|Bacteria,1V53J@1239|Firmicutes,4H26R@909932|Negativicutes	909932|Negativicutes	V	PFAM secretion protein HlyD family protein	-	-	-	ko:K03543	-	M00701	-	-	ko00000,ko00002,ko02000	8.A.1.1	-	-	HlyD_D23
SHD1_k127_3292120_2	1144275.COCOR_05869	7.5e-117	396.0	2DNVT@1|root,32ZDR@2|Bacteria,1QWIA@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_3292120_0	1183438.GKIL_3259	5.601e-146	509.0	COG0383@1|root,COG0383@2|Bacteria,1G1RB@1117|Cyanobacteria	1117|Cyanobacteria	G	PFAM Glycosyl hydrolases family 38 C-terminal domain	ams1	-	3.2.1.24	ko:K01191	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04131	-	GH38	-	Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C
SHD1_k127_3292120_4	867845.KI911784_gene2212	9.218e-23	113.0	COG5305@1|root,COG5305@2|Bacteria,2G7AA@200795|Chloroflexi,375E4@32061|Chloroflexia	32061|Chloroflexia	S	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	DUF2723,PMT_2
SHD1_k127_3299676_2	56110.Oscil6304_5587	4.87e-40	152.0	COG2848@1|root,COG2848@2|Bacteria,1G3IK@1117|Cyanobacteria	1117|Cyanobacteria	S	Uncharacterised ACR (DUF711)	-	-	-	ko:K09157	-	-	-	-	ko00000	-	-	-	DUF711
SHD1_k127_3299676_3	468059.AUHA01000006_gene2940	1.659e-07	63.0	2AE6H@1|root,30WB0@2|Bacteria,4P9QI@976|Bacteroidetes,1IZ9B@117747|Sphingobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_3299676_1	861299.J421_6235	5.796e-67	239.0	COG2370@1|root,COG2370@2|Bacteria,1ZV64@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	HupE / UreJ protein	-	-	-	-	-	-	-	-	-	-	-	-	HupE_UreJ_2
SHD1_k127_3299676_0	861299.J421_6234	1.278e-88	308.0	COG0457@1|root,COG0457@2|Bacteria	861299.J421_6234|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_3302719_7	234267.Acid_6457	1.344e-49	182.0	COG1914@1|root,COG1914@2|Bacteria	2|Bacteria	P	metal ion transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	Nramp
SHD1_k127_3302719_2	861299.J421_0072	5.709e-113	380.0	COG0116@1|root,COG0116@2|Bacteria,1ZT80@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	Putative RNA methylase family UPF0020	-	-	-	ko:K07444	-	-	-	-	ko00000,ko01000	-	-	-	UPF0020
SHD1_k127_3302719_4	861299.J421_0149	3.237e-63	224.0	COG0122@1|root,COG0122@2|Bacteria,1ZTST@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	endonuclease III	-	-	3.2.2.21	ko:K01247	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
SHD1_k127_3302719_5	1379270.AUXF01000003_gene3804	8.856e-58	207.0	COG2928@1|root,COG2928@2|Bacteria,1ZTMN@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Protein of unknown function (DUF502)	-	-	-	-	-	-	-	-	-	-	-	-	DUF502
SHD1_k127_3302719_11	861299.J421_2461	1.406e-07	63.0	2DTE6@1|root,33JYQ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_3302719_9	1121405.dsmv_1643	3.231e-44	165.0	COG1764@1|root,COG1764@2|Bacteria,1RH9U@1224|Proteobacteria,42TWN@68525|delta/epsilon subdivisions,2WQDD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	OsmC-like protein	osmC	-	-	ko:K04063	-	-	-	-	ko00000	-	-	-	OsmC
SHD1_k127_3302719_6	1379270.AUXF01000002_gene1709	1.663e-57	203.0	COG2166@1|root,COG2166@2|Bacteria,1ZTPH@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Fe-S metabolism associated domain	-	-	-	ko:K02426	-	-	-	-	ko00000	-	-	-	SufE
SHD1_k127_3302719_10	1454007.JAUG01000013_gene2360	1.254e-11	71.0	2D0AC@1|root,32T87@2|Bacteria,4NSVN@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_3302719_3	497964.CfE428DRAFT_6060	4.225e-110	373.0	COG0451@1|root,COG0451@2|Bacteria,46SEK@74201|Verrucomicrobia	74201|Verrucomicrobia	GM	NAD dependent epimerase/dehydratase family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
SHD1_k127_3302719_1	861299.J421_0086	3.984e-140	467.0	COG0329@1|root,COG0329@2|Bacteria,1ZTEC@142182|Gemmatimonadetes	142182|Gemmatimonadetes	EM	Dihydrodipicolinate synthetase family	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_3302719_8	234267.Acid_7855	4.482e-46	174.0	COG2323@1|root,COG2323@2|Bacteria,3Y4R1@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF421)	-	-	-	-	-	-	-	-	-	-	-	-	DUF421
SHD1_k127_3302719_0	379066.GAU_0336	1.989e-141	456.0	COG2204@1|root,COG2204@2|Bacteria,1ZTDN@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
SHD1_k127_3323187_1	379066.GAU_1368	4.371e-72	248.0	COG0498@1|root,COG0498@2|Bacteria,1ZSVV@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
SHD1_k127_3323187_0	671143.DAMO_2610	1.617e-114	379.0	COG0160@1|root,COG0160@2|Bacteria,2NNRV@2323|unclassified Bacteria	2|Bacteria	E	Aminotransferase class-III	gabT	-	2.6.1.19,2.6.1.22,2.6.1.33,2.6.1.36	ko:K03918,ko:K07250,ko:K20428	ko00250,ko00280,ko00410,ko00525,ko00640,ko00650,ko01100,ko01120,ko01130,map00250,map00280,map00410,map00525,map00640,map00650,map01100,map01120,map01130	M00027	R00457,R00908,R01648,R02773,R04188	RC00006,RC00062,RC00160,RC00781	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
SHD1_k127_3332991_5	861299.J421_5909	1.479e-66	254.0	COG0642@1|root,COG2205@2|Bacteria	861299.J421_5909|-	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_3332991_6	1128421.JAGA01000001_gene2144	7.101e-56	201.0	COG3127@1|root,COG3127@2|Bacteria	2|Bacteria	Q	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
SHD1_k127_3332991_7	1128421.JAGA01000001_gene2145	6.69e-33	133.0	COG1846@1|root,COG1846@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	MA20_05735	-	-	-	-	-	-	-	-	-	-	-	HTH_34
SHD1_k127_3332991_2	1096546.WYO_3494	1.284e-82	282.0	COG0020@1|root,COG0020@2|Bacteria,1MVP1@1224|Proteobacteria,2TU0N@28211|Alphaproteobacteria,1JSI3@119045|Methylobacteriaceae	28211|Alphaproteobacteria	H	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	MA20_23565	GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
SHD1_k127_3332991_3	240015.ACP_1064	4.355e-81	283.0	COG3315@1|root,COG3315@2|Bacteria,3Y6AW@57723|Acidobacteria,2JKQT@204432|Acidobacteriia	204432|Acidobacteriia	H	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	LCM
SHD1_k127_3332991_1	861299.J421_3680	5.151e-87	295.0	COG3253@1|root,COG3253@2|Bacteria	2|Bacteria	S	peroxidase activity	ywfI	-	-	ko:K00435	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R11522	RC00884	ko00000,ko00001,ko01000	-	-	-	Chlor_dismutase
SHD1_k127_3332991_4	1144275.COCOR_03639	1.363e-66	237.0	COG2220@1|root,COG2220@2|Bacteria,1MUY6@1224|Proteobacteria,42Q5T@68525|delta/epsilon subdivisions	1224|Proteobacteria	S	Belongs to the UPF0173 family	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2,Lactamase_B_3
SHD1_k127_3332991_0	1122604.JONR01000013_gene3243	5.837e-131	428.0	COG3511@1|root,COG3511@2|Bacteria,1R78F@1224|Proteobacteria,1S2GR@1236|Gammaproteobacteria,1X929@135614|Xanthomonadales	135614|Xanthomonadales	M	Phosphoesterase family	-	-	-	-	-	-	-	-	-	-	-	-	Phosphoesterase
SHD1_k127_3332991_8	1288494.EBAPG3_10110	4.973e-32	126.0	2BW7N@1|root,32Z97@2|Bacteria,1P2ZF@1224|Proteobacteria,2W4Y3@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_3332991_10	1356852.N008_04995	7.701e-20	98.0	COG1215@1|root,COG1215@2|Bacteria,4NFI8@976|Bacteroidetes,47PPF@768503|Cytophagia	976|Bacteroidetes	M	Pfam:DUF2029	-	-	-	-	-	-	-	-	-	-	-	-	GT87
SHD1_k127_3339364_9	1267533.KB906740_gene158	2.528e-48	177.0	COG0842@1|root,COG1511@1|root,COG0842@2|Bacteria,COG1511@2|Bacteria,3Y65Z@57723|Acidobacteria,2JM5S@204432|Acidobacteriia	204432|Acidobacteriia	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
SHD1_k127_3339364_13	1121439.dsat_2811	1.554e-30	132.0	COG1309@1|root,COG1309@2|Bacteria,1NDME@1224|Proteobacteria,42MYP@68525|delta/epsilon subdivisions,2WKKZ@28221|Deltaproteobacteria,2MCQF@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	Transcriptional regulator TetR	-	-	-	-	-	-	-	-	-	-	-	-	DUF1956,TetR_N
SHD1_k127_3339364_12	861299.J421_5974	6.515e-35	143.0	COG2932@1|root,COG2932@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S24
SHD1_k127_3339364_3	861299.J421_2063	1.077e-121	397.0	COG0648@1|root,COG0648@2|Bacteria,1ZT71@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	Xylose isomerase-like TIM barrel	-	-	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
SHD1_k127_3339364_0	379066.GAU_3073	1.965e-254	796.0	COG1012@1|root,COG1012@2|Bacteria,1ZSRK@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Aldehyde dehydrogenase family	-	-	1.2.1.88	ko:K00294	ko00250,ko00330,ko01100,map00250,map00330,map01100	-	R00245,R00707,R00708,R04444,R04445,R05051	RC00080,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000	-	-	-	Aldedh
SHD1_k127_3339364_4	118163.Ple7327_4469	1.202e-92	313.0	COG0384@1|root,COG0384@2|Bacteria,1G0Y0@1117|Cyanobacteria	1117|Cyanobacteria	S	TIGRFAM phenazine biosynthesis protein PhzF family	-	-	5.3.3.17	ko:K06998	ko00405,ko01130,ko02024,map00405,map01130,map02024	M00835	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	PhzC-PhzF
SHD1_k127_3339364_5	379066.GAU_3075	1.157e-83	292.0	COG2199@1|root,COG3706@2|Bacteria,1ZUI1@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
SHD1_k127_3339364_10	1089553.Tph_c26700	1.931e-40	156.0	COG0853@1|root,COG0853@2|Bacteria,1V6NQ@1239|Firmicutes,24JVN@186801|Clostridia,42GKF@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine	panD	-	4.1.1.11	ko:K01579	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R00489	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Asp_decarbox
SHD1_k127_3339364_7	1128421.JAGA01000002_gene1381	2.528e-78	280.0	COG0624@1|root,COG0624@2|Bacteria,2NQ4M@2323|unclassified Bacteria	2|Bacteria	E	Peptidase family M20/M25/M40	-	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28,Peptidase_M42
SHD1_k127_3339364_2	861299.J421_0566	5.694e-139	476.0	COG0577@1|root,COG0577@2|Bacteria	861299.J421_0566|-	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_3339364_11	861299.J421_0639	1.192e-39	151.0	COG1695@1|root,COG1695@2|Bacteria	2|Bacteria	K	negative regulation of transcription, DNA-templated	-	-	-	-	-	-	-	-	-	-	-	-	PadR
SHD1_k127_3339364_1	861299.J421_5961	1.478e-231	738.0	COG1473@1|root,COG1473@2|Bacteria,1ZSTC@142182|Gemmatimonadetes	2|Bacteria	S	Peptidase dimerisation domain	-	-	-	ko:K12941	-	-	-	-	ko00000,ko01002	-	-	-	M20_dimer,Peptidase_M20
SHD1_k127_3339364_6	861299.J421_4544	2.369e-83	287.0	COG0697@1|root,COG0697@2|Bacteria,1ZTM7@142182|Gemmatimonadetes	142182|Gemmatimonadetes	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
SHD1_k127_3344032_0	861299.J421_3024	5.787e-163	521.0	COG1012@1|root,COG1012@2|Bacteria,1ZT7A@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Aldehyde dehydrogenase family	-	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
SHD1_k127_3344032_2	1121380.JNIW01000025_gene728	2.956e-30	126.0	COG0662@1|root,COG0662@2|Bacteria	2|Bacteria	G	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,Cupin_2,HTH_18,HTH_AraC
SHD1_k127_3344032_1	479434.Sthe_3388	1.045e-42	158.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,2G62W@200795|Chloroflexi,27YXY@189775|Thermomicrobia	189775|Thermomicrobia	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdopterin,Molydop_binding
SHD1_k127_3351120_8	1385935.N836_10125	1.157e-34	137.0	COG0578@1|root,COG0578@2|Bacteria,1G1T3@1117|Cyanobacteria,1H86N@1150|Oscillatoriales	1117|Cyanobacteria	C	FAD dependent oxidoreductase	-	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,DAO_C
SHD1_k127_3351120_7	861299.J421_2623	1.984e-36	150.0	COG1463@1|root,COG1463@2|Bacteria	2|Bacteria	Q	ABC-type transport system involved in resistance to organic solvents, periplasmic component	-	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD,OmpA
SHD1_k127_3351120_4	880072.Desac_0962	1.77e-53	202.0	COG1994@1|root,COG1994@2|Bacteria,1QZHR@1224|Proteobacteria,43CIT@68525|delta/epsilon subdivisions,2X7T2@28221|Deltaproteobacteria,2MRQV@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Peptidase family M50	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
SHD1_k127_3351120_0	861299.J421_2622	5.953e-217	679.0	COG1158@1|root,COG1158@2|Bacteria,1ZSXH@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	-	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
SHD1_k127_3351120_3	861299.J421_2621	1.005e-55	199.0	COG0816@1|root,COG0816@2|Bacteria,1ZTWG@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA	-	-	-	ko:K07447	-	-	-	-	ko00000,ko01000	-	-	-	RuvX
SHD1_k127_3351120_1	861299.J421_2620	5.892e-110	367.0	COG1559@1|root,COG1559@2|Bacteria,1ZTA7@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
SHD1_k127_3351120_6	926550.CLDAP_21780	7.99e-38	145.0	COG4401@1|root,COG4401@2|Bacteria,2G6VB@200795|Chloroflexi	200795|Chloroflexi	E	PFAM Chorismate mutase of the AroH class	-	-	5.4.99.5	ko:K06208	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R01715	RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	CM_1
SHD1_k127_3351120_5	383372.Rcas_4121	3.604e-38	150.0	COG0352@1|root,COG0352@2|Bacteria,2G6P0@200795|Chloroflexi,375RT@32061|Chloroflexia	32061|Chloroflexia	H	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)	thiE	GO:0003674,GO:0003824,GO:0004789,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.3	ko:K00788	ko00730,ko01100,map00730,map01100	M00127	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	TMP-TENI
SHD1_k127_3351120_2	861299.J421_2619	2.951e-80	279.0	COG2206@1|root,COG2206@2|Bacteria	2|Bacteria	T	PFAM metal-dependent phosphohydrolase, HD sub domain	rpfG	-	-	ko:K02030,ko:K06950,ko:K07814,ko:K09749,ko:K16923	-	M00236,M00582	-	-	ko00000,ko00002,ko02000,ko02022	3.A.1.28,3.A.1.3	-	-	GAF_2,GGDEF,HD,HD_5,PAS_4,PAS_9,Response_reg
SHD1_k127_3352951_0	861299.J421_3356	5.384e-176	562.0	COG0173@1|root,COG0173@2|Bacteria,1ZTFX@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
SHD1_k127_3352951_4	1156937.MFUM_40015	9.873e-15	80.0	COG5652@1|root,COG5652@2|Bacteria,46Z0R@74201|Verrucomicrobia,37GZJ@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	S	VanZ like family	-	-	-	-	-	-	-	-	-	-	-	-	VanZ
SHD1_k127_3352951_1	861299.J421_3358	2.457e-154	496.0	COG0820@1|root,COG0820@2|Bacteria,1ZTAJ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	-	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Radical_SAM
SHD1_k127_3352951_3	1379270.AUXF01000006_gene171	1.877e-53	196.0	COG1713@1|root,COG1713@2|Bacteria,1ZTTH@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	HD superfamily hydrolase involved in NAD metabolism	-	-	2.7.6.3	ko:K00950	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	-
SHD1_k127_3352951_2	1122611.KB903943_gene1483	4.714e-82	280.0	COG0414@1|root,COG0414@2|Bacteria,2GJEQ@201174|Actinobacteria,4EG66@85012|Streptosporangiales	201174|Actinobacteria	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate	panC	GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_ligase
SHD1_k127_3375317_2	767434.Fraau_3038	7.375e-62	225.0	COG1073@1|root,COG1073@2|Bacteria,1QZCA@1224|Proteobacteria,1T45H@1236|Gammaproteobacteria,1XD8D@135614|Xanthomonadales	135614|Xanthomonadales	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_3375317_5	644282.Deba_3100	2.998e-23	114.0	COG0438@1|root,COG0438@2|Bacteria,1PVZ8@1224|Proteobacteria,42TY9@68525|delta/epsilon subdivisions,2WQH3@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	COG0438 Glycosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4
SHD1_k127_3375317_1	1095769.CAHF01000010_gene1299	2.45e-81	286.0	COG0438@1|root,COG0438@2|Bacteria,1QU2N@1224|Proteobacteria,2VJ9J@28216|Betaproteobacteria,476WG@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4
SHD1_k127_3375317_3	518766.Rmar_0576	1.996e-48	181.0	COG4122@1|root,COG4122@2|Bacteria	2|Bacteria	E	O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_24
SHD1_k127_3375317_0	861299.J421_2685	2.415e-192	606.0	COG0403@1|root,COG1003@1|root,COG0403@2|Bacteria,COG1003@2|Bacteria,1ZSUZ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvP	-	1.4.4.2	ko:K00281	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	GDC-P
SHD1_k127_3393316_1	485913.Krac_3321	1.709e-31	130.0	COG3832@1|root,COG3832@2|Bacteria	2|Bacteria	J	glyoxalase III activity	-	-	2.7.7.19	ko:K00970	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	FA_hydroxylase,Polyketide_cyc2
SHD1_k127_3393316_0	861299.J421_0835	5.919e-61	223.0	2DQ6W@1|root,3350G@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_3433649_3	1121286.AUMT01000017_gene3861	1.974e-25	106.0	COG1225@1|root,COG1225@2|Bacteria,4NQCB@976|Bacteroidetes,1I3EE@117743|Flavobacteriia,3ZUGE@59732|Chryseobacterium	976|Bacteroidetes	O	Redoxin	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
SHD1_k127_3433649_1	29540.C481_02312	3.149e-55	199.0	COG1651@1|root,arCOG02868@2157|Archaea,2XW8R@28890|Euryarchaeota,23U3Q@183963|Halobacteria	183963|Halobacteria	OP	DSBA-like thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_4
SHD1_k127_3433649_2	861299.J421_1239	1.945e-46	176.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_ECF
SHD1_k127_3433649_0	1089550.ATTH01000001_gene1831	1.167e-111	389.0	COG0515@1|root,COG0515@2|Bacteria,4NPN9@976|Bacteroidetes,1FJI6@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	KLT	Protein tyrosine kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	NERD,Pkinase,TPR_12,TPR_8
SHD1_k127_3445487_2	68223.JNZY01000048_gene3530	1.25e-32	130.0	COG0384@1|root,COG0384@2|Bacteria	2|Bacteria	S	isomerase activity	-	-	-	ko:K07054	-	-	-	-	ko00000	-	-	-	PhzC-PhzF
SHD1_k127_3445487_1	1394178.AWOO02000006_gene3385	1.783e-77	271.0	COG2423@1|root,COG2423@2|Bacteria,2IBTX@201174|Actinobacteria	201174|Actinobacteria	E	Ornithine cyclodeaminase/mu-crystallin family	-	-	-	-	-	-	-	-	-	-	-	-	OCD_Mu_crystall
SHD1_k127_3445487_0	886293.Sinac_2843	4.477e-177	572.0	COG1680@1|root,COG2173@1|root,COG1680@2|Bacteria,COG2173@2|Bacteria,2IWSU@203682|Planctomycetes	203682|Planctomycetes	MV	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,Peptidase_M15
SHD1_k127_3450965_4	861299.J421_1517	3.715e-40	160.0	COG0457@1|root,COG0457@2|Bacteria	861299.J421_1517|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_3450965_0	1267535.KB906767_gene5108	5.164e-167	556.0	COG0577@1|root,COG0577@2|Bacteria,3Y31H@57723|Acidobacteria,2JITF@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
SHD1_k127_3450965_2	861299.J421_0639	1.251e-41	157.0	COG1695@1|root,COG1695@2|Bacteria	2|Bacteria	K	negative regulation of transcription, DNA-templated	-	-	-	-	-	-	-	-	-	-	-	-	PadR
SHD1_k127_3450965_1	485918.Cpin_1971	5.863e-145	492.0	COG2982@1|root,COG2982@2|Bacteria,4NEJQ@976|Bacteroidetes,1IRAR@117747|Sphingobacteriia	976|Bacteroidetes	M	AsmA-like C-terminal region	-	-	-	ko:K07289	-	-	-	-	ko00000	-	-	-	AsmA,AsmA_2
SHD1_k127_3450965_3	861299.J421_0408	2.046e-41	154.0	2E3MN@1|root,32NV6@2|Bacteria,1ZV65@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Cytochrome C and Quinol oxidase polypeptide I	-	-	-	-	-	-	-	-	-	-	-	-	COX1
SHD1_k127_345925_6	379066.GAU_2351	7.083e-93	317.0	COG1989@1|root,COG1989@2|Bacteria,1ZT9K@142182|Gemmatimonadetes	142182|Gemmatimonadetes	NOU	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue	-	-	3.4.23.43	ko:K02654	-	M00331	-	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2	-	-	DiS_P_DiS,Peptidase_A24
SHD1_k127_345925_10	861299.J421_3833	6.822e-77	265.0	COG0566@1|root,COG0566@2|Bacteria,1ZTVA@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	RNA 2'-O ribose methyltransferase substrate binding	-	-	-	ko:K03437	-	-	-	-	ko00000,ko03016	-	-	-	SpoU_methylase,SpoU_sub_bind
SHD1_k127_345925_11	1121035.AUCH01000005_gene125	2.161e-41	164.0	COG2199@1|root,COG3706@2|Bacteria,1MYK0@1224|Proteobacteria	1224|Proteobacteria	T	COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Response_reg
SHD1_k127_345925_8	1330700.JQNC01000001_gene2179	3.252e-80	275.0	COG0351@1|root,COG0351@2|Bacteria,1WIN0@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	H	Phosphomethylpyrimidine kinase	thiD	-	2.7.1.49,2.7.4.7	ko:K00941	ko00730,ko01100,map00730,map01100	M00127	R03471,R04509	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Phos_pyr_kin
SHD1_k127_345925_7	861299.J421_3835	4.215e-88	301.0	COG0005@1|root,COG0005@2|Bacteria,1ZTGZ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate	-	-	2.4.2.1	ko:K03783	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244	RC00033,RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
SHD1_k127_345925_3	861299.J421_3836	1.99e-117	387.0	COG1816@1|root,COG1816@2|Bacteria,1ZSQ6@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Adenosine/AMP deaminase	-	-	3.5.4.4	ko:K01488	ko00230,ko01100,ko05340,map00230,map01100,map05340	-	R01560,R02556	RC00477	ko00000,ko00001,ko01000	-	-	-	A_deaminase
SHD1_k127_345925_13	379066.GAU_2356	7.642e-07	61.0	290N8@1|root,2ZNAK@2|Bacteria,1ZU7A@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_345925_0	379066.GAU_2357	3.112e-171	554.0	COG0737@1|root,COG0737@2|Bacteria,1ZTEA@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	5'-nucleotidase, C-terminal domain	-	-	3.1.3.5	ko:K01081	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	5_nucleotid_C,Metallophos
SHD1_k127_345925_9	861299.J421_3839	3.305e-78	266.0	COG0572@1|root,COG0572@2|Bacteria,1ZSM3@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Cytidylate kinase	udk	-	2.7.1.48	ko:K00876	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PRK
SHD1_k127_345925_4	379066.GAU_2359	8.782e-110	361.0	COG0745@1|root,COG0745@2|Bacteria,1ZTC6@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Transcriptional regulatory protein, C terminal	-	-	-	ko:K07657	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
SHD1_k127_345925_2	1379270.AUXF01000003_gene3567	1.175e-117	407.0	COG5002@1|root,COG5002@2|Bacteria,1ZT2H@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	HAMP domain	-	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA
SHD1_k127_345925_1	316067.Geob_1997	1.257e-118	391.0	COG0226@1|root,COG0226@2|Bacteria,1MUAZ@1224|Proteobacteria,42NM3@68525|delta/epsilon subdivisions,2WMH9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Part of the ABC transporter complex PstSACB involved in phosphate import	pstS	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
SHD1_k127_345925_12	795359.TOPB45_0456	4.754e-08	65.0	COG3203@1|root,COG3203@2|Bacteria,2GI8G@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	M	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_345925_5	379066.GAU_2365	9.808e-102	340.0	COG0226@1|root,COG0226@2|Bacteria,1ZUH8@142182|Gemmatimonadetes	142182|Gemmatimonadetes	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
SHD1_k127_3461383_1	861299.J421_1760	1.305e-81	298.0	COG0515@1|root,COG0515@2|Bacteria,1ZUFG@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
SHD1_k127_3461383_0	379066.GAU_2541	3.591e-129	424.0	COG0389@1|root,COG0389@2|Bacteria,1ZT65@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C
SHD1_k127_3461383_3	379066.GAU_0096	1.381e-17	88.0	COG0729@1|root,COG1752@1|root,COG0729@2|Bacteria,COG1752@2|Bacteria	2|Bacteria	M	Esterase of the alpha-beta hydrolase superfamily	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Bac_surface_Ag,Patatin
SHD1_k127_3461383_2	379066.GAU_2887	1.139e-79	278.0	COG0745@1|root,COG0745@2|Bacteria,1ZUUR@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Transcriptional regulatory protein, C terminal	-	-	-	ko:K07667	ko02020,ko02024,map02020,map02024	M00454	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
SHD1_k127_3466395_5	204669.Acid345_0578	2.49e-17	95.0	COG0671@1|root,COG0671@2|Bacteria,3Y8GC@57723|Acidobacteria	2|Bacteria	I	PAP2 superfamily	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	GT87,PAP2_3
SHD1_k127_3466395_3	1128421.JAGA01000002_gene905	6.419e-140	460.0	COG2230@1|root,COG2230@2|Bacteria	2|Bacteria	M	cyclopropane-fatty-acyl-phospholipid synthase	-	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	iAF987.Gmet_2187	CMAS
SHD1_k127_3466395_1	861299.J421_1364	5.163e-167	534.0	COG3503@1|root,COG3503@2|Bacteria	2|Bacteria	J	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF1624,DUF418
SHD1_k127_3466395_2	1267535.KB906767_gene5024	1.498e-154	501.0	COG1409@1|root,COG3794@1|root,COG1409@2|Bacteria,COG3794@2|Bacteria,3Y3P7@57723|Acidobacteria,2JIMH@204432|Acidobacteriia	204432|Acidobacteriia	C	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
SHD1_k127_3466395_4	861299.J421_4305	7.842e-27	113.0	COG0614@1|root,COG0614@2|Bacteria,1ZV3K@142182|Gemmatimonadetes	142182|Gemmatimonadetes	P	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_3
SHD1_k127_3466395_0	861299.J421_0588	7.293e-191	605.0	COG4447@1|root,COG4447@2|Bacteria,1ZSRH@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Sortilin, neurotensin receptor 3,	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
SHD1_k127_3467269_1	861299.J421_0650	6.439e-46	170.0	COG0662@1|root,COG0662@2|Bacteria,1ZV9R@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
SHD1_k127_3467269_0	861299.J421_1035	2.87e-109	366.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
SHD1_k127_3469805_8	1267535.KB906767_gene402	1.629e-47	171.0	COG1053@1|root,COG1053@2|Bacteria,3Y2MQ@57723|Acidobacteria,2JIC4@204432|Acidobacteriia	204432|Acidobacteriia	C	Succinate dehydrogenase or fumarate reductase, flavoprotein subunit	-	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
SHD1_k127_3469805_2	861299.J421_3298	2.387e-116	380.0	COG0479@1|root,COG0479@2|Bacteria,1ZT02@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	4Fe-4S binding domain	-	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_8
SHD1_k127_3469805_5	379066.GAU_1663	3.531e-102	340.0	COG0717@1|root,COG0717@2|Bacteria,1ZSN3@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	dUTPase	dcd	-	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	dUTPase
SHD1_k127_3469805_7	379066.GAU_1662	1.748e-60	211.0	COG0838@1|root,COG0838@2|Bacteria,1ZTKK@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoA	-	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
SHD1_k127_3469805_3	1379270.AUXF01000006_gene230	5.895e-104	341.0	COG0377@1|root,COG0377@2|Bacteria,1ZT85@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
SHD1_k127_3469805_4	861299.J421_3293	2.85e-103	343.0	COG0852@1|root,COG0852@2|Bacteria,1ZTCJ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
SHD1_k127_3469805_0	861299.J421_3292	2.939e-233	728.0	COG0649@1|root,COG0649@2|Bacteria,1ZSV6@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
SHD1_k127_3469805_6	861299.J421_3291	5.595e-74	256.0	COG1905@1|root,COG1905@2|Bacteria,1ZTJ9@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Thioredoxin-like [2Fe-2S] ferredoxin	-	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
SHD1_k127_3469805_1	379066.GAU_1657	4.049e-229	714.0	COG1894@1|root,COG1894@2|Bacteria,1ZSQD@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	-	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
SHD1_k127_3480566_1	1122604.JONR01000025_gene4602	5.957e-39	160.0	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1SHX7@1236|Gammaproteobacteria,1X4MN@135614|Xanthomonadales	135614|Xanthomonadales	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Trans_reg_C
SHD1_k127_3480566_0	234267.Acid_4591	2.864e-50	183.0	COG2318@1|root,COG2318@2|Bacteria,3Y501@57723|Acidobacteria	57723|Acidobacteria	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
SHD1_k127_3480566_3	1035191.HMPREF0185_01735	3.862e-33	135.0	COG0454@1|root,COG0456@2|Bacteria,1Q5AK@1224|Proteobacteria,2TUP8@28211|Alphaproteobacteria,2KH97@204458|Caulobacterales	204458|Caulobacterales	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
SHD1_k127_3480566_2	1449126.JQKL01000036_gene1950	2.514e-37	158.0	COG2931@1|root,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	FG-GAP,HemolysinCabind
SHD1_k127_3480566_4	1122604.JONR01000025_gene4602	8.276e-05	55.0	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1SHX7@1236|Gammaproteobacteria,1X4MN@135614|Xanthomonadales	135614|Xanthomonadales	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Trans_reg_C
SHD1_k127_3502498_0	861299.J421_3812	5.24e-322	995.0	COG0296@1|root,COG0296@2|Bacteria,1ZT8Y@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
SHD1_k127_3502498_1	479434.Sthe_2691	1.546e-292	914.0	COG1523@1|root,COG1523@2|Bacteria,2G86B@200795|Chloroflexi	200795|Chloroflexi	G	Belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
SHD1_k127_3502498_3	861299.J421_1950	1.509e-215	686.0	COG0296@1|root,COG0296@2|Bacteria	2|Bacteria	G	1,4-alpha-glucan branching enzyme activity	treZ	GO:0000272,GO:0003674,GO:0003824,GO:0004553,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005984,GO:0005991,GO:0005992,GO:0006073,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009251,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016052,GO:0016787,GO:0016798,GO:0030978,GO:0030980,GO:0033942,GO:0034637,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0071704,GO:1901575,GO:1901576	3.2.1.141	ko:K01236	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11256	RC00049	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48,DUF3459
SHD1_k127_3502498_4	272943.RSP_2446	1.309e-66	253.0	COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,1MVKX@1224|Proteobacteria,2TRS3@28211|Alphaproteobacteria,1FCD3@1060|Rhodobacter	28211|Alphaproteobacteria	G	PFAM alpha amylase, catalytic	treS	-	3.2.1.1,5.4.99.16	ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R02108,R02112,R11262	RC01816	ko00000,ko00001,ko01000	-	GH13	-	APH,Alpha-amylase,Malt_amylase_C
SHD1_k127_3502498_2	861299.J421_3815	4.09e-286	885.0	COG0366@1|root,COG0366@2|Bacteria	2|Bacteria	G	hydrolase activity, hydrolyzing O-glycosyl compounds	treS	-	3.2.1.1,5.4.99.16	ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R02108,R02112,R11262	RC01816	ko00000,ko00001,ko01000	-	GH13	-	APH,Alpha-amylase,Malt_amylase_C
SHD1_k127_350359_4	379066.GAU_0780	1.543e-86	291.0	COG0302@1|root,COG0302@2|Bacteria,1ZT6I@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	GTP cyclohydrolase I	folE	-	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydroI
SHD1_k127_350359_6	1379270.AUXF01000004_gene3096	3.162e-63	225.0	COG4221@1|root,COG4221@2|Bacteria,1ZTPW@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
SHD1_k127_350359_8	861299.J421_2706	2.575e-36	147.0	2FCPE@1|root,344SN@2|Bacteria,1ZU2F@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_350359_2	861299.J421_2707	2.572e-229	724.0	COG1022@1|root,COG1022@2|Bacteria,1ZT60@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	AMP-binding enzyme	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
SHD1_k127_350359_12	1379270.AUXF01000004_gene3093	6.952e-10	70.0	2AEY4@1|root,314VZ@2|Bacteria,1ZUUQ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_350359_3	1379270.AUXF01000004_gene3092	1.117e-110	362.0	COG0455@1|root,COG0455@2|Bacteria,1ZTAN@142182|Gemmatimonadetes	142182|Gemmatimonadetes	D	Cellulose biosynthesis protein BcsQ	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
SHD1_k127_350359_7	861299.J421_2711	9.244e-59	208.0	COG0457@1|root,COG0457@2|Bacteria,1ZTX0@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_11
SHD1_k127_350359_5	861299.J421_2712	4.94e-68	235.0	COG2236@1|root,COG2236@2|Bacteria,1ZTQ2@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Phosphoribosyl transferase domain	-	-	-	ko:K07101	-	-	-	-	ko00000	-	-	-	Pribosyltran
SHD1_k127_350359_1	861299.J421_6180	1.186e-237	770.0	COG0577@1|root,COG0577@2|Bacteria	861299.J421_6180|-	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_350359_10	861299.J421_0257	4.541e-29	121.0	COG1695@1|root,COG1695@2|Bacteria	2|Bacteria	K	negative regulation of transcription, DNA-templated	-	-	-	-	-	-	-	-	-	-	-	-	PadR
SHD1_k127_350359_9	1379270.AUXF01000004_gene3089	7.454e-30	125.0	COG1719@1|root,COG1719@2|Bacteria,1ZU65@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	4-vinyl reductase, 4VR	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_350359_0	1379270.AUXF01000004_gene3088	1.311e-249	788.0	COG0272@1|root,COG0272@2|Bacteria,1ZT5Q@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
SHD1_k127_350359_11	1297742.A176_02760	3.491e-23	107.0	COG0642@1|root,COG2199@1|root,COG2205@2|Bacteria,COG3706@2|Bacteria,1NRP8@1224|Proteobacteria,4304I@68525|delta/epsilon subdivisions,2WVDN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	sensor histidine kinase response	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GGDEF,HATPase_c,HisKA,Response_reg
SHD1_k127_3505324_3	861299.J421_4135	1.707e-105	356.0	COG0515@1|root,COG0515@2|Bacteria,1ZUAC@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
SHD1_k127_3505324_5	861299.J421_4136	3.718e-15	89.0	2C9ZZ@1|root,33QSF@2|Bacteria,1ZUIY@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_3505324_8	290317.Cpha266_1155	2.374e-06	61.0	COG1357@1|root,COG4412@1|root,COG1357@2|Bacteria,COG4412@2|Bacteria	2|Bacteria	S	peptidase activity, acting on L-amino acid peptides	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	-
SHD1_k127_3505324_1	383372.Rcas_0710	8.533e-251	784.0	COG0166@1|root,COG0166@2|Bacteria,2G5ZM@200795|Chloroflexi,376U7@32061|Chloroflexia	32061|Chloroflexia	F	glucose-6-phosphate isomerase activity	pgi	-	5.3.1.9	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI
SHD1_k127_3505324_4	215803.DB30_1941	3.348e-48	189.0	COG0077@1|root,COG0077@2|Bacteria,1MU60@1224|Proteobacteria,42MGN@68525|delta/epsilon subdivisions,2WJET@28221|Deltaproteobacteria,2YZIB@29|Myxococcales	28221|Deltaproteobacteria	E	Prephenate dehydratase	pheA	-	4.2.1.51,5.4.99.5	ko:K04518,ko:K14170	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R00691,R01373,R01715	RC00360,RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,CM_2,PDT
SHD1_k127_3505324_0	234267.Acid_4582	1.146e-305	971.0	COG2234@1|root,COG2234@2|Bacteria,3Y435@57723|Acidobacteria	57723|Acidobacteria	S	Transferrin receptor-like dimerisation domain	-	-	3.4.17.21	ko:K01301	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PA,Peptidase_M28,TFR_dimer
SHD1_k127_3505324_2	234267.Acid_1476	2.098e-117	390.0	COG0013@1|root,COG0013@2|Bacteria,3Y4AR@57723|Acidobacteria	57723|Acidobacteria	J	Threonyl and Alanyl tRNA synthetase second additional domain	-	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
SHD1_k127_3505324_7	1347086.CCBA010000025_gene3140	3.281e-10	73.0	COG1164@1|root,COG1164@2|Bacteria,1U8XY@1239|Firmicutes,4HEV8@91061|Bacilli,1ZC0S@1386|Bacillus	91061|Bacilli	E	Peptidase M3A and M3B thimet oligopeptidase F	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M2,Peptidase_M3
SHD1_k127_3505324_6	379066.GAU_3894	2.494e-12	72.0	COG0705@1|root,COG0705@2|Bacteria,1ZSWV@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
SHD1_k127_3510837_6	379066.GAU_2526	6.48e-16	78.0	COG3852@1|root,COG3852@2|Bacteria,1ZSYP@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	PAS domain	-	-	2.7.13.3	ko:K02668	ko02020,map02020	M00501	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	HATPase_c,HisKA
SHD1_k127_3510837_0	1379270.AUXF01000003_gene3386	5.853e-213	672.0	COG2204@1|root,COG2204@2|Bacteria,1ZSRQ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
SHD1_k127_3510837_3	379066.GAU_2522	1.358e-71	272.0	COG4191@1|root,COG4191@2|Bacteria,1ZSSB@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
SHD1_k127_3510837_2	398767.Glov_2158	7.872e-140	458.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K07714	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
SHD1_k127_3510837_5	1379270.AUXF01000002_gene1795	1.556e-24	114.0	2F5SD@1|root,33YB8@2|Bacteria,1ZUXW@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_3510837_1	1379270.AUXF01000003_gene3394	6.276e-146	473.0	COG4972@1|root,COG4972@2|Bacteria,1ZSYA@142182|Gemmatimonadetes	142182|Gemmatimonadetes	NU	Type IV pilus assembly protein PilM;	-	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilM_2
SHD1_k127_3510837_4	1379270.AUXF01000003_gene3395	9.699e-27	113.0	COG3166@1|root,COG3166@2|Bacteria,1ZTR8@142182|Gemmatimonadetes	142182|Gemmatimonadetes	NU	Fimbrial assembly protein (PilN)	-	-	-	-	-	-	-	-	-	-	-	-	PilN
SHD1_k127_3517329_1	941449.dsx2_3431	9.1e-172	547.0	COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,42M67@68525|delta/epsilon subdivisions,2WJQX@28221|Deltaproteobacteria,2M9RZ@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	PFAM Cys Met metabolism	-	-	2.5.1.48	ko:K01739	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00999,R01288,R02508,R03217,R03260,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00420,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
SHD1_k127_3517329_2	861299.J421_3139	6.859e-62	217.0	COG0590@1|root,COG0590@2|Bacteria,1ZTW9@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)	tadA	-	3.5.4.33,3.8.1.5	ko:K01563,ko:K11991	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05284,R05367,R05368,R05369,R05370,R07669,R07670,R10223	RC00477,RC01317,RC01340,RC01341,RC02013	ko00000,ko00001,ko01000,ko03016	-	-	-	MafB19-deam
SHD1_k127_3517329_0	1303518.CCALI_00290	2.425e-213	675.0	COG0542@1|root,COG0542@2|Bacteria	2|Bacteria	O	response to heat	clpB	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K03694,ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
SHD1_k127_3524490_3	204669.Acid345_4447	2.172e-54	207.0	COG2067@1|root,COG2067@2|Bacteria,3Y3JJ@57723|Acidobacteria,2JJB9@204432|Acidobacteriia	204432|Acidobacteriia	I	Putative beta-barrel porin-2, OmpL-like. bbp2	-	-	-	-	-	-	-	-	-	-	-	-	BBP2
SHD1_k127_3524490_0	357808.RoseRS_1958	2.909e-158	509.0	COG0473@1|root,COG0473@2|Bacteria,2G63C@200795|Chloroflexi,3755M@32061|Chloroflexia	32061|Chloroflexia	C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
SHD1_k127_3524490_2	926569.ANT_03320	2.695e-68	244.0	COG0066@1|root,COG0066@2|Bacteria,2G6JE@200795|Chloroflexi	200795|Chloroflexi	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	-	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
SHD1_k127_3524490_1	1128421.JAGA01000002_gene1558	3.51e-136	438.0	COG0065@1|root,COG0065@2|Bacteria,2NP2K@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	GO:0003674,GO:0003824,GO:0003861,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009316,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016866,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iEcE24377_1341.EcE24377A_0075,iPC815.YPO0531,iSB619.SA_RS10700	Aconitase
SHD1_k127_3530145_1	1121104.AQXH01000006_gene2339	3.102e-10	71.0	COG0457@1|root,COG0457@2|Bacteria,4NU11@976|Bacteroidetes	976|Bacteroidetes	S	Protein of unknown function (DUF2911)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2911
SHD1_k127_3530145_0	1122223.KB890687_gene2687	1.64e-80	282.0	COG1167@1|root,COG1167@2|Bacteria,1WM9Y@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	K	helix_turn_helix gluconate operon transcriptional repressor	-	-	-	ko:K00375	-	-	-	-	ko00000,ko03000	-	-	-	Aminotran_1_2,GntR
SHD1_k127_3536189_3	1056495.Calag_0824	0.0007513	51.0	COG0589@1|root,arCOG02053@2157|Archaea,2XQTK@28889|Crenarchaeota	28889|Crenarchaeota	T	PFAM UspA domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
SHD1_k127_3536189_0	483219.LILAB_26115	2.986e-108	370.0	COG0642@1|root,COG3829@1|root,COG2205@2|Bacteria,COG3829@2|Bacteria,1NRP8@1224|Proteobacteria,42Z45@68525|delta/epsilon subdivisions,2WTWB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HAMP,HATPase_c,HisKA,PAS_4
SHD1_k127_3536189_2	1379270.AUXF01000007_gene905	1.645e-33	141.0	COG0589@1|root,COG0589@2|Bacteria,1ZUGW@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	Family of unknown function (DUF5335)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5335,Usp
SHD1_k127_3536189_1	1366050.N234_02615	7.965e-105	361.0	COG2989@1|root,COG2989@2|Bacteria,1MV14@1224|Proteobacteria,2VHVQ@28216|Betaproteobacteria,1K6VT@119060|Burkholderiaceae	28216|Betaproteobacteria	S	L,D-transpeptidase catalytic domain	ycbB	-	-	ko:K21470	-	-	-	-	ko00000,ko01002,ko01011	-	-	-	PG_binding_1,YkuD
SHD1_k127_3536990_1	420324.KI912036_gene2518	1.296e-125	410.0	COG1680@1|root,COG1680@2|Bacteria,1P3SQ@1224|Proteobacteria,2TTI5@28211|Alphaproteobacteria,1JTV3@119045|Methylobacteriaceae	28211|Alphaproteobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
SHD1_k127_3536990_3	204669.Acid345_2044	8.982e-28	116.0	COG0662@1|root,COG0662@2|Bacteria,3Y8RS@57723|Acidobacteria,2JNY9@204432|Acidobacteriia	204432|Acidobacteriia	G	AraC-like ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
SHD1_k127_3536990_0	861299.J421_1024	7.1e-151	505.0	COG2132@1|root,COG2132@2|Bacteria,1ZUD9@142182|Gemmatimonadetes	142182|Gemmatimonadetes	Q	Multicopper oxidase	-	-	1.16.3.3	ko:K22348	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_2,Cu-oxidase_3
SHD1_k127_3536990_2	1267533.KB906735_gene4675	1.816e-47	183.0	2D579@1|root,32TID@2|Bacteria,3Y88C@57723|Acidobacteria,2JNCR@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_3545448_3	700598.Niako_4637	1.038e-61	222.0	2CYFR@1|root,32T44@2|Bacteria,4P6IN@976|Bacteroidetes,1IZDY@117747|Sphingobacteriia	976|Bacteroidetes	S	Protein of unknown function (DUF998)	-	-	-	-	-	-	-	-	-	-	-	-	DUF998
SHD1_k127_3545448_4	861299.J421_6341	1.614e-46	173.0	COG1917@1|root,COG1917@2|Bacteria,1ZTY8@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
SHD1_k127_3545448_2	861299.J421_6340	7.219e-104	352.0	COG1028@1|root,COG1028@2|Bacteria,1ZTIT@142182|Gemmatimonadetes	142182|Gemmatimonadetes	IQ	KR domain	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
SHD1_k127_3545448_1	1382356.JQMP01000004_gene188	2.896e-107	362.0	COG0436@1|root,COG0436@2|Bacteria,2G5MC@200795|Chloroflexi,27YSW@189775|Thermomicrobia	189775|Thermomicrobia	E	Aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
SHD1_k127_3545448_0	861299.J421_2245	3.433e-169	539.0	COG2421@1|root,COG2421@2|Bacteria,1ZSR0@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Acetamidase/Formamidase family	-	-	-	-	-	-	-	-	-	-	-	-	FmdA_AmdA
SHD1_k127_3545448_5	1121920.AUAU01000004_gene719	1.709e-44	176.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y333@57723|Acidobacteria	57723|Acidobacteria	KLTU	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Pkinase
SHD1_k127_3558068_1	1449076.JOOE01000001_gene2245	3.188e-110	372.0	COG3104@1|root,COG3104@2|Bacteria,1MW6W@1224|Proteobacteria,2U15C@28211|Alphaproteobacteria,2K2WX@204457|Sphingomonadales	204457|Sphingomonadales	E	amino acid peptide transporter	-	-	-	ko:K03305	-	-	-	-	ko00000	2.A.17	-	-	PTR2
SHD1_k127_3558068_2	1379270.AUXF01000001_gene1891	5.362e-62	220.0	COG3544@1|root,COG3544@2|Bacteria,1ZUFH@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Domain of unknown function (DUF4142)	-	-	-	-	-	-	-	-	-	-	-	-	DUF305
SHD1_k127_3558068_0	1379270.AUXF01000001_gene1892	1.505e-207	666.0	COG5276@1|root,COG5276@2|Bacteria,1ZU8A@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	LVIVD repeat	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
SHD1_k127_3564440_7	861299.J421_3271	2.716e-27	113.0	COG0331@1|root,COG0331@2|Bacteria,1ZT40@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Acyl transferase domain	-	-	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
SHD1_k127_3564440_4	379066.GAU_1637	1.742e-105	352.0	COG1028@1|root,COG1028@2|Bacteria,1ZT4H@142182|Gemmatimonadetes	142182|Gemmatimonadetes	IQ	KR domain	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
SHD1_k127_3564440_6	861299.J421_3269	9.929e-30	119.0	COG0236@1|root,COG0236@2|Bacteria,1ZU0X@142182|Gemmatimonadetes	142182|Gemmatimonadetes	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
SHD1_k127_3564440_1	1191523.MROS_2456	1.36e-156	505.0	COG0304@1|root,COG0304@2|Bacteria	2|Bacteria	I	3-oxoacyl-[acyl-carrier-protein] synthase activity	fabF	-	2.3.1.179	ko:K09458,ko:K14660	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	iSB619.SA_RS04785	Ketoacyl-synt_C,ketoacyl-synt
SHD1_k127_3564440_2	234267.Acid_1309	1.603e-116	387.0	COG1060@1|root,COG1060@2|Bacteria,3Y331@57723|Acidobacteria	57723|Acidobacteria	H	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate	mqnE	-	2.5.1.120	ko:K18285	ko00130,ko01110,map00130,map01110	-	R10667	RC00021,RC03234	ko00000,ko00001,ko01000	-	-	-	Radical_SAM
SHD1_k127_3564440_3	379066.GAU_1633	1.722e-114	376.0	COG1427@1|root,COG1427@2|Bacteria,1ZT6H@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnA	-	4.2.1.151	ko:K11782	ko00130,ko01110,map00130,map01110	-	R10666	RC03232	ko00000,ko00001,ko01000	-	-	-	VitK2_biosynth
SHD1_k127_3564440_0	1379270.AUXF01000006_gene258	1.869e-189	596.0	COG1060@1|root,COG1060@2|Bacteria,1ZSU1@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnC	-	1.21.98.1	ko:K11784	ko00130,ko01110,map00130,map01110	-	R08588	RC02329	ko00000,ko00001,ko01000	-	-	-	Radical_SAM
SHD1_k127_3564440_5	861299.J421_3264	8.604e-57	203.0	COG0245@1|root,COG0245@2|Bacteria,1ZTM5@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)	ispF	-	4.6.1.12	ko:K01770	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	YgbB
SHD1_k127_3564440_8	861299.J421_3262	2.274e-22	103.0	COG4974@1|root,COG4974@2|Bacteria,1ZTAH@142182|Gemmatimonadetes	142182|Gemmatimonadetes	D	Phage integrase, N-terminal SAM-like domain	xerD	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
SHD1_k127_3567511_2	1283284.AZUK01000001_gene284	1.016e-37	147.0	COG0412@1|root,COG0412@2|Bacteria,1MW7S@1224|Proteobacteria,1RPGK@1236|Gammaproteobacteria,1Y61V@135624|Aeromonadales	135624|Aeromonadales	Q	Dienelactone hydrolase family	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
SHD1_k127_3567511_0	861299.J421_1921	2.705e-163	539.0	COG0642@1|root,COG2205@2|Bacteria	861299.J421_1921|-	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_3567511_1	1242864.D187_009684	6.97e-60	213.0	COG0380@1|root,COG0380@2|Bacteria,1MUIY@1224|Proteobacteria,42NBU@68525|delta/epsilon subdivisions,2WJX9@28221|Deltaproteobacteria,2YU3V@29|Myxococcales	28221|Deltaproteobacteria	G	glycosyl transferase family	otsAB	-	2.4.1.15,2.4.1.347,3.1.3.12	ko:K00697,ko:K16055	ko00500,ko01100,map00500,map01100	-	R02737,R02778	RC00005,RC00017,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT20	-	Glyco_transf_20,S6PP,Trehalose_PPase
SHD1_k127_3599170_1	379066.GAU_2634	1.613e-53	204.0	2EZKR@1|root,33SRW@2|Bacteria,1ZSQ9@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_3599170_0	1288494.EBAPG3_4650	3.608e-176	562.0	COG4941@1|root,COG4941@2|Bacteria,1MU3D@1224|Proteobacteria,2VKYD@28216|Betaproteobacteria,37424@32003|Nitrosomonadales	28216|Betaproteobacteria	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
SHD1_k127_3599170_3	349521.HCH_05597	4.659e-40	152.0	COG3795@1|root,COG3795@2|Bacteria,1N32U@1224|Proteobacteria,1S82G@1236|Gammaproteobacteria,1XKS3@135619|Oceanospirillales	135619|Oceanospirillales	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	YCII
SHD1_k127_3599170_2	1227739.Hsw_2021	2.238e-46	184.0	COG3975@1|root,COG3975@2|Bacteria,4NGTY@976|Bacteroidetes,47KE2@768503|Cytophagia	976|Bacteroidetes	S	protease with the C-terminal PDZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Peptidase_M61
SHD1_k127_359965_4	861299.J421_2266	4.327e-43	180.0	COG3653@1|root,COG3653@2|Bacteria,1ZTDH@142182|Gemmatimonadetes	142182|Gemmatimonadetes	Q	Amidohydrolase family	-	-	3.5.1.81	ko:K06015	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Amidohydro_3
SHD1_k127_359965_1	379066.GAU_2031	1.692e-176	575.0	COG0531@1|root,COG0531@2|Bacteria,1ZUQJ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Amino acid permease	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
SHD1_k127_359965_5	379066.GAU_2029	1.061e-40	167.0	COG3375@1|root,COG3375@2|Bacteria,1ZUBU@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	carboxylic acid catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_359965_2	861299.J421_6090	6.277e-71	252.0	COG1802@1|root,COG1802@2|Bacteria,1ZUBC@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
SHD1_k127_359965_0	1122927.KB895420_gene4165	5.853e-181	592.0	COG1680@1|root,COG1680@2|Bacteria,1V4BS@1239|Firmicutes,4HJRT@91061|Bacilli,26R26@186822|Paenibacillaceae	91061|Bacilli	V	Beta-lactamase class C and other penicillin binding proteins	pbpX	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
SHD1_k127_359965_3	886293.Sinac_2843	5.076e-57	216.0	COG1680@1|root,COG2173@1|root,COG1680@2|Bacteria,COG2173@2|Bacteria,2IWSU@203682|Planctomycetes	203682|Planctomycetes	MV	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,Peptidase_M15
SHD1_k127_3601287_1	861299.J421_4174	2.398e-116	387.0	COG1132@1|root,COG1132@2|Bacteria,1ZSP1@142182|Gemmatimonadetes	142182|Gemmatimonadetes	V	ABC transporter transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	ABC_membrane,ABC_tran
SHD1_k127_3601287_0	861299.J421_4172	4.895e-124	406.0	COG0109@1|root,COG0109@2|Bacteria,1ZSP3@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	ctaB	-	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
SHD1_k127_3611681_2	379066.GAU_1766	3.845e-95	321.0	COG0515@1|root,COG0515@2|Bacteria,1ZTE2@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
SHD1_k127_3611681_3	1379270.AUXF01000006_gene129	2.749e-35	136.0	COG0184@1|root,COG0184@2|Bacteria,1ZU0C@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	-	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
SHD1_k127_3611681_0	379066.GAU_1764	0.0	1058.0	COG1185@1|root,COG1185@2|Bacteria,1ZT7C@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	-	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
SHD1_k127_3611681_1	861299.J421_3400	3.516e-100	334.0	COG0612@1|root,COG0612@2|Bacteria,1ZSPT@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Insulinase (Peptidase family M16)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
SHD1_k127_361754_2	861299.J421_2483	7.959e-77	288.0	COG0438@1|root,COG0438@2|Bacteria,1ZV2U@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_361754_0	861299.J421_2479	2.284e-103	353.0	COG2244@1|root,COG2244@2|Bacteria,1ZUPR@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Polysaccharide biosynthesis protein	-	-	-	ko:K03328	-	-	-	-	ko00000	2.A.66.2	-	-	Polysacc_synt_3,Polysacc_synt_C
SHD1_k127_361754_4	448385.sce5461	5.097e-37	155.0	COG0438@1|root,COG0438@2|Bacteria,1MU9C@1224|Proteobacteria,42R6N@68525|delta/epsilon subdivisions,2WKF4@28221|Deltaproteobacteria,2Z2XV@29|Myxococcales	28221|Deltaproteobacteria	H	High confidence in function and specificity	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
SHD1_k127_361754_3	443143.GM18_1661	3.192e-47	185.0	COG1215@1|root,COG1215@2|Bacteria,1QUFX@1224|Proteobacteria,42R2C@68525|delta/epsilon subdivisions,2WMZ7@28221|Deltaproteobacteria,43V8U@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	PFAM glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glycos_transf_2
SHD1_k127_361754_1	861299.J421_2495	6.905e-81	279.0	COG2148@1|root,COG2148@2|Bacteria,1ZSW2@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	Bacterial sugar transferase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf
SHD1_k127_361754_5	379066.GAU_0580	7.493e-34	142.0	COG1596@1|root,COG1596@2|Bacteria,1ZTXZ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	polysaccharide export	-	-	-	-	-	-	-	-	-	-	-	-	SLBB
SHD1_k127_361754_6	1366050.N234_33285	3.129e-11	70.0	COG0642@1|root,COG0784@1|root,COG3437@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,COG3437@2|Bacteria,1NRP8@1224|Proteobacteria,2VIZX@28216|Betaproteobacteria,1KIJ5@119060|Burkholderiaceae	28216|Betaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,Response_reg
SHD1_k127_3628271_4	941449.dsx2_3223	2.307e-106	359.0	COG0025@1|root,COG0025@2|Bacteria,1QTUE@1224|Proteobacteria,43CF5@68525|delta/epsilon subdivisions,2WMDP@28221|Deltaproteobacteria,2MHIG@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
SHD1_k127_3628271_7	670307.HYPDE_40568	9.43e-73	253.0	COG4280@1|root,COG4280@2|Bacteria,1R6ER@1224|Proteobacteria,2U4XX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Uncharacterized protein family UPF0016	-	-	-	-	-	-	-	-	-	-	-	-	OFeT_1,UPF0016
SHD1_k127_3628271_12	1121920.AUAU01000011_gene137	8.996e-23	107.0	COG2020@1|root,COG2020@2|Bacteria	2|Bacteria	O	methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
SHD1_k127_3628271_2	1382306.JNIM01000001_gene1966	3.62e-144	473.0	COG0076@1|root,COG0076@2|Bacteria,2G7N6@200795|Chloroflexi	200795|Chloroflexi	E	Pyridoxal-dependent decarboxylase conserved domain	-	-	4.1.1.105,4.1.1.28,4.1.2.27	ko:K01593,ko:K01634	ko00350,ko00360,ko00380,ko00600,ko00901,ko00950,ko00965,ko01100,ko01110,ko04071,ko04726,ko04728,ko05030,ko05031,ko05034,map00350,map00360,map00380,map00600,map00901,map00950,map00965,map01100,map01110,map04071,map04726,map04728,map05030,map05031,map05034	M00037,M00042,M00100	R00685,R00699,R00736,R02080,R02464,R02701,R04909,R06516	RC00264,RC00299,RC00721,RC01266	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyridoxal_deC
SHD1_k127_3628271_5	219305.MCAG_00867	5.841e-97	330.0	COG1215@1|root,COG1215@2|Bacteria,2IAQ1@201174|Actinobacteria	201174|Actinobacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glyco_transf_21
SHD1_k127_3628271_6	375286.mma_1651	1.049e-82	285.0	COG3665@1|root,COG3665@2|Bacteria,1N9DM@1224|Proteobacteria,2VMBK@28216|Betaproteobacteria,477VW@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Domain of unknown function (DUF1989)	-	-	-	ko:K09967	-	-	-	-	ko00000	-	-	-	DUF1989
SHD1_k127_3628271_10	1192034.CAP_3644	1.119e-54	201.0	COG3403@1|root,COG3665@1|root,COG3403@2|Bacteria,COG3665@2|Bacteria,1N9DM@1224|Proteobacteria,42QUI@68525|delta/epsilon subdivisions,2WSPS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Domain of unknown function (DUF1989)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1989
SHD1_k127_3628271_8	1198114.AciX9_2979	2.645e-69	252.0	COG1835@1|root,COG1835@2|Bacteria,3Y5EG@57723|Acidobacteria,2JJNH@204432|Acidobacteriia	204432|Acidobacteriia	I	PFAM acyltransferase 3	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
SHD1_k127_3628271_0	861299.J421_5907	2.288e-178	568.0	COG1252@1|root,COG1252@2|Bacteria,1ZT8C@142182|Gemmatimonadetes	2|Bacteria	C	Pyridine nucleotide-disulphide oxidoreductase	ndh	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
SHD1_k127_3628271_1	1040989.AWZU01000035_gene1772	3.748e-178	578.0	COG0654@1|root,COG0654@2|Bacteria,1MUN4@1224|Proteobacteria,2TQT8@28211|Alphaproteobacteria,3JTRW@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	CH	FAD binding domain	pcpB	-	1.14.13.127	ko:K05712	ko00360,ko01120,ko01220,map00360,map01120,map01220	M00545	R06786,R06787	RC00236	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_3
SHD1_k127_3628271_3	1379270.AUXF01000001_gene2681	2.013e-137	462.0	COG0415@1|root,COG0415@2|Bacteria,1ZUPI@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	DNA photolyase	-	-	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase
SHD1_k127_3628271_9	381666.H16_B2288	1.804e-68	241.0	COG0599@1|root,COG2021@1|root,COG0599@2|Bacteria,COG2021@2|Bacteria,1QU84@1224|Proteobacteria,2WHMV@28216|Betaproteobacteria,1KG83@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Carboxymuconolactone decarboxylase family	-	-	3.1.1.24,4.1.1.44	ko:K14727	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00568	R02991,R03470	RC00825,RC00938	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1,CMD
SHD1_k127_3628271_11	861299.J421_3651	1.165e-36	146.0	COG1695@1|root,COG1695@2|Bacteria	2|Bacteria	K	negative regulation of transcription, DNA-templated	yqjI	GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0006950,GO:0006974,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141	-	-	-	-	-	-	-	-	-	-	PadR
SHD1_k127_3653666_2	861299.J421_3663	2.304e-62	219.0	COG1228@1|root,COG1228@2|Bacteria,1ZSU7@142182|Gemmatimonadetes	142182|Gemmatimonadetes	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
SHD1_k127_3653666_0	861299.J421_3650	2.725e-122	407.0	COG1131@1|root,COG1131@2|Bacteria,1ZTMK@142182|Gemmatimonadetes	2|Bacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
SHD1_k127_3653666_1	861299.J421_3649	1.909e-96	325.0	COG0842@1|root,COG0842@2|Bacteria	2|Bacteria	V	Transport permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
SHD1_k127_3653666_3	479434.Sthe_0672	2.614e-22	100.0	COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,2G84K@200795|Chloroflexi,27XSV@189775|Thermomicrobia	200795|Chloroflexi	P	Rhodanese Homology Domain	-	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	Lactamase_B,Rhodanese
SHD1_k127_367137_1	118166.JH976537_gene3002	8.308e-44	177.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,1G1QI@1117|Cyanobacteria,1H7BP@1150|Oscillatoriales	1117|Cyanobacteria	NU	TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,TPR_10,TPR_12,TPR_7,TPR_8
SHD1_k127_367137_2	502025.Hoch_4319	1.682e-19	94.0	COG0346@1|root,COG0346@2|Bacteria,1NB98@1224|Proteobacteria	1224|Proteobacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
SHD1_k127_367137_0	861299.J421_3038	2.122e-83	298.0	COG0308@1|root,COG0823@1|root,COG0308@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	VVA0929	-	3.4.11.2	ko:K01256,ko:K03641	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002,ko02000	2.C.1.2	-	-	PD40,Peptidase_MA_2
SHD1_k127_3672134_0	118168.MC7420_1668	1.979e-152	496.0	COG0591@1|root,COG0591@2|Bacteria,1G1JV@1117|Cyanobacteria,1H88V@1150|Oscillatoriales	1117|Cyanobacteria	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	putP	-	-	-	-	-	-	-	-	-	-	-	SSF
SHD1_k127_3672134_1	1379270.AUXF01000004_gene2956	2.915e-91	317.0	COG0631@1|root,COG0631@2|Bacteria,1ZT1X@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	Serine/threonine phosphatases, family 2C, catalytic domain	-	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C_2
SHD1_k127_3672134_2	1192034.CAP_7898	1.025e-33	142.0	COG1716@1|root,COG1716@2|Bacteria,1QH9U@1224|Proteobacteria,434RS@68525|delta/epsilon subdivisions,2WZ2V@28221|Deltaproteobacteria,2Z17M@29|Myxococcales	28221|Deltaproteobacteria	T	FHA domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA
SHD1_k127_3689185_2	861299.J421_3468	7.18e-13	69.0	COG0484@1|root,COG0484@2|Bacteria,1ZSVD@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	-	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
SHD1_k127_3689185_1	1379270.AUXF01000006_gene61	4.379e-136	441.0	COG1420@1|root,COG1420@2|Bacteria,1ZTER@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	-	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HrcA
SHD1_k127_3689185_0	861299.J421_3470	1.225e-148	479.0	COG0635@1|root,COG0635@2|Bacteria,1ZSSU@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Involved in the biosynthesis of porphyrin-containing compound	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
SHD1_k127_369282_4	1379270.AUXF01000002_gene1833	4.208e-52	185.0	COG2027@1|root,COG2027@2|Bacteria,1ZT1Q@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	D-Ala-D-Ala carboxypeptidase 3 (S13) family	-	-	3.4.16.4	ko:K07259	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	Peptidase_S13
SHD1_k127_369282_1	420662.Mpe_A0329	4.337e-137	445.0	COG3616@1|root,COG3616@2|Bacteria,1MVQE@1224|Proteobacteria,2VIUU@28216|Betaproteobacteria	28216|Betaproteobacteria	E	Alanine racemase	-	-	4.1.2.42	ko:K19967	-	-	-	-	ko00000,ko01000	-	-	-	Ala_racemase_N,D-ser_dehydrat
SHD1_k127_369282_0	861299.J421_2400	5.418e-178	565.0	COG1748@1|root,COG1748@2|Bacteria,1ZSMC@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Saccharopine dehydrogenase C-terminal domain	-	-	1.4.1.18	ko:K19064	ko00960,ko01100,ko01110,map00960,map01100,map01110	-	R00446,R02317	RC00062,RC00694	ko00000,ko00001,ko01000	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP
SHD1_k127_369282_6	743721.Psesu_2582	2.237e-10	65.0	2EKH8@1|root,33E79@2|Bacteria,1QBBW@1224|Proteobacteria,1T6WM@1236|Gammaproteobacteria,1X8B9@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_369282_3	861299.J421_2399	4.459e-57	208.0	COG1832@1|root,COG1832@2|Bacteria,1ZTUU@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	CoA binding domain	-	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
SHD1_k127_369282_2	316274.Haur_3122	1.03e-86	300.0	COG2133@1|root,COG2133@2|Bacteria,2G7VF@200795|Chloroflexi,377AV@32061|Chloroflexia	32061|Chloroflexia	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
SHD1_k127_369282_5	1123288.SOV_7c00420	1.683e-15	81.0	COG1071@1|root,COG1071@2|Bacteria,1TQDG@1239|Firmicutes,4H3DP@909932|Negativicutes	909932|Negativicutes	C	Dehydrogenase E1 component	-	-	-	-	-	-	-	-	-	-	-	-	E1_dh
SHD1_k127_3693126_0	886293.Sinac_2439	1.372e-103	352.0	COG3391@1|root,COG3511@1|root,COG3391@2|Bacteria,COG3511@2|Bacteria,2IX7F@203682|Planctomycetes	203682|Planctomycetes	M	Phosphoesterase family	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase,Phosphoesterase
SHD1_k127_3693126_1	543728.Vapar_6213	8.046e-11	73.0	COG1680@1|root,COG1680@2|Bacteria,1P3SQ@1224|Proteobacteria,2VQGI@28216|Betaproteobacteria	28216|Betaproteobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
SHD1_k127_3703315_2	743721.Psesu_1285	8.408e-54	201.0	COG1175@1|root,COG1175@2|Bacteria,1MVAP@1224|Proteobacteria,1S6CY@1236|Gammaproteobacteria,1X3CM@135614|Xanthomonadales	135614|Xanthomonadales	P	ABC-type sugar transport systems, permease components	lacF	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
SHD1_k127_3703315_1	215803.DB30_8575	3.676e-150	488.0	COG1653@1|root,COG1653@2|Bacteria,1MX59@1224|Proteobacteria	1224|Proteobacteria	G	ABC transporter substrate-binding protein	malE	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
SHD1_k127_3703315_0	861299.J421_1673	5.728e-155	497.0	COG5368@1|root,COG5368@2|Bacteria	2|Bacteria	S	Putative glucoamylase	-	-	-	-	-	-	-	-	-	-	-	-	Glycoamylase
SHD1_k127_3710361_1	1379270.AUXF01000004_gene3355	1.125e-163	522.0	COG1363@1|root,COG1363@2|Bacteria,1ZTF5@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	M42 glutamyl aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M42
SHD1_k127_3710361_4	379066.GAU_0542	2.77e-78	290.0	COG0614@1|root,COG0614@2|Bacteria,1ZUER@142182|Gemmatimonadetes	142182|Gemmatimonadetes	P	Periplasmic binding protein	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
SHD1_k127_3710361_0	1192034.CAP_8674	9.835e-192	624.0	COG1297@1|root,COG1297@2|Bacteria,1N7SK@1224|Proteobacteria,42PMM@68525|delta/epsilon subdivisions,2WWD4@28221|Deltaproteobacteria,2YTYG@29|Myxococcales	28221|Deltaproteobacteria	S	oligopeptide transporter, OPT family	-	-	-	-	-	-	-	-	-	-	-	-	OPT
SHD1_k127_3710361_5	861299.J421_5612	9.463e-70	248.0	COG3206@1|root,COG3206@2|Bacteria	2|Bacteria	M	extracellular polysaccharide biosynthetic process	-	-	-	ko:K13582	ko04112,map04112	-	-	-	ko00000,ko00001	-	-	-	DUF4349
SHD1_k127_3710361_3	1128421.JAGA01000002_gene1168	7.862e-97	341.0	COG4251@1|root,COG4251@2|Bacteria,2NS53@2323|unclassified Bacteria	2|Bacteria	T	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,Response_reg
SHD1_k127_3710361_6	1519464.HY22_05730	1.241e-66	250.0	COG3975@1|root,COG3975@2|Bacteria,1FEP2@1090|Chlorobi	1090|Chlorobi	S	M61 glycyl aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Peptidase_M61
SHD1_k127_3710361_7	445335.CBN_1296	3.091e-05	55.0	2BI9C@1|root,32CEV@2|Bacteria,1TYTW@1239|Firmicutes,24XA7@186801|Clostridia,36Q03@31979|Clostridiaceae	186801|Clostridia	S	Yip1 domain	-	-	-	-	-	-	-	-	-	-	-	-	Yip1
SHD1_k127_3710361_2	379066.GAU_0555	1.931e-135	435.0	COG1960@1|root,COG1960@2|Bacteria,1ZT6S@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
SHD1_k127_3713854_2	204669.Acid345_3034	3.967e-92	318.0	COG2271@1|root,COG2271@2|Bacteria,3Y3W5@57723|Acidobacteria,2JK7R@204432|Acidobacteriia	204432|Acidobacteriia	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SHD1_k127_3713854_3	29581.BW37_04925	5.487e-56	204.0	COG3545@1|root,COG3545@2|Bacteria,1RDB7@1224|Proteobacteria,2VQ1M@28216|Betaproteobacteria,474UC@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Serine hydrolase	-	-	-	ko:K07002	-	-	-	-	ko00000	-	-	-	Ser_hydrolase
SHD1_k127_3713854_0	861299.J421_0867	1.752e-132	456.0	COG0515@1|root,COG0515@2|Bacteria	861299.J421_0867|-	KLT	protein kinase activity	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	-
SHD1_k127_3713854_1	861299.J421_6223	1.315e-104	357.0	COG2091@1|root,COG2091@2|Bacteria,1ZUE3@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	lysine biosynthetic process via aminoadipic acid	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_3728624_3	338966.Ppro_0305	1.592e-19	94.0	COG1763@1|root,COG1763@2|Bacteria,1RD3Q@1224|Proteobacteria,42RZK@68525|delta/epsilon subdivisions,2WQ3C@28221|Deltaproteobacteria,43SFT@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	mobB	-	2.7.7.77	ko:K03753,ko:K13818	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	MobB,NTP_transf_3
SHD1_k127_3728624_0	861299.J421_3926	3.513e-131	434.0	COG2027@1|root,COG2027@2|Bacteria,1ZSQ3@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	D-Ala-D-Ala carboxypeptidase 3 (S13) family	-	-	3.4.16.4	ko:K07259	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	Peptidase_S13
SHD1_k127_3728624_1	861299.J421_3927	6.092e-120	407.0	COG0303@1|root,COG0303@2|Bacteria,1ZT4D@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	MoeA N-terminal region (domain I and II)	-	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
SHD1_k127_3728624_2	379066.GAU_2463	5.832e-54	198.0	COG3897@1|root,COG3897@2|Bacteria,1ZTUN@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Lysine methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_3733305_5	861299.J421_2927	4.35e-48	175.0	COG0621@1|root,COG0621@2|Bacteria,1ZT70@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12	rimO	-	2.8.4.4	ko:K14441	-	-	R10652	RC00003,RC03217	ko00000,ko01000,ko03009	-	-	-	Radical_SAM,UPF0004
SHD1_k127_3733305_1	1379270.AUXF01000005_gene351	2.246e-172	560.0	COG1228@1|root,COG1228@2|Bacteria,1ZSME@142182|Gemmatimonadetes	142182|Gemmatimonadetes	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
SHD1_k127_3733305_0	861299.J421_0810	3.708e-179	574.0	COG0624@1|root,COG0624@2|Bacteria	2|Bacteria	E	succinyl-diaminopimelate desuccinylase activity	cpg2_2	-	3.4.17.11	ko:K01295	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
SHD1_k127_3733305_4	861299.J421_2925	3.788e-69	239.0	COG1666@1|root,COG1666@2|Bacteria,1ZTNB@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Protein of unknown function (DUF520)	-	-	-	ko:K09767	-	-	-	-	ko00000	-	-	-	DUF520
SHD1_k127_3733305_2	861299.J421_1395	2.268e-109	368.0	COG2234@1|root,COG2234@2|Bacteria,1ZSXY@142182|Gemmatimonadetes	2|Bacteria	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
SHD1_k127_3733305_6	379066.GAU_2648	1.928e-27	117.0	COG5349@1|root,COG5349@2|Bacteria,1ZU3C@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Protein of unknown function (DUF983)	-	-	-	-	-	-	-	-	-	-	-	-	DUF983
SHD1_k127_3733305_3	861299.J421_2922	2.606e-82	275.0	COG0568@1|root,COG0568@2|Bacteria,1ZSR6@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
SHD1_k127_3739972_0	402626.Rpic_3767	9.418e-153	492.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,1K375@119060|Burkholderiaceae	28216|Betaproteobacteria	T	response regulator	zraR	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
SHD1_k127_3739972_1	365046.Rta_02210	1.431e-26	112.0	COG1335@1|root,COG1335@2|Bacteria,1MZP9@1224|Proteobacteria,2VSME@28216|Betaproteobacteria,4AEYF@80864|Comamonadaceae	28216|Betaproteobacteria	Q	isochorismatase hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
SHD1_k127_3748479_0	861299.J421_3867	2.236e-238	745.0	COG0147@1|root,COG0147@2|Bacteria,1ZSPU@142182|Gemmatimonadetes	142182|Gemmatimonadetes	EH	Anthranilate synthase component I, N terminal region	trpE	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
SHD1_k127_3748479_1	861299.J421_3868	4.363e-126	423.0	COG2114@1|root,COG2203@1|root,COG2114@2|Bacteria,COG2203@2|Bacteria,1ZT7U@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	FHA,GAF,Guanylate_cyc
SHD1_k127_3748479_3	861299.J421_3869	1.342e-54	201.0	COG3642@1|root,COG3642@2|Bacteria,1ZTTJ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	Lipopolysaccharide kinase (Kdo/WaaP) family	-	-	2.7.1.166	ko:K11211	ko00540,map00540	-	R09767	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	Kdo
SHD1_k127_3748479_2	861299.J421_3870	7.43e-126	420.0	COG0859@1|root,COG0859@2|Bacteria,1ZT3G@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	ko:K12982	-	-	-	-	ko00000,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
SHD1_k127_3748479_4	1125863.JAFN01000001_gene535	6.515e-49	191.0	COG0438@1|root,COG0438@2|Bacteria,1MU9C@1224|Proteobacteria,42R6N@68525|delta/epsilon subdivisions,2WP3W@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
SHD1_k127_3748479_6	309807.SRU_0281	2.574e-43	180.0	COG0438@1|root,COG0438@2|Bacteria,4NEWR@976|Bacteroidetes,1FK1J@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	M	Glycosyl transferases group 1	gmhA	-	2.4.1.346	ko:K13668	-	-	R11703,R11704	-	ko00000,ko01000,ko01003	-	GT4	-	Glyco_transf_4,Glyco_transf_5,Glycos_transf_1
SHD1_k127_3748479_5	1125863.JAFN01000001_gene535	5.18e-46	182.0	COG0438@1|root,COG0438@2|Bacteria,1MU9C@1224|Proteobacteria,42R6N@68525|delta/epsilon subdivisions,2WP3W@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
SHD1_k127_3748479_7	1499967.BAYZ01000068_gene1947	5.125e-23	102.0	COG0463@1|root,COG0463@2|Bacteria	2|Bacteria	M	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	DUF4254
SHD1_k127_3748479_9	1009370.ALO_19347	1.929e-09	64.0	COG0859@1|root,COG0859@2|Bacteria,1UZZI@1239|Firmicutes,4H2VC@909932|Negativicutes	909932|Negativicutes	M	PFAM glycosyl transferase family 9	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9
SHD1_k127_3749982_0	861299.J421_3084	3.6e-313	972.0	COG1200@1|root,COG1200@2|Bacteria,1ZT3C@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
SHD1_k127_3749982_3	861299.J421_3083	4.246e-128	416.0	COG0552@1|root,COG0552@2|Bacteria,1ZTBT@142182|Gemmatimonadetes	142182|Gemmatimonadetes	D	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
SHD1_k127_3749982_2	861299.J421_3082	1.079e-149	494.0	COG1572@1|root,COG1572@2|Bacteria,1ZSTW@142182|Gemmatimonadetes	142182|Gemmatimonadetes	NU	bacterial-type flagellum-dependent cell motility	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_3749982_4	379066.GAU_1440	1.002e-115	396.0	COG0739@1|root,COG0739@2|Bacteria,1ZSUW@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
SHD1_k127_3749982_1	861299.J421_3080	1.229e-197	622.0	COG0206@1|root,COG0206@2|Bacteria,1ZSNH@142182|Gemmatimonadetes	142182|Gemmatimonadetes	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
SHD1_k127_3749982_5	861299.J421_3079	1.206e-25	108.0	COG0849@1|root,COG0849@2|Bacteria,1ZSRE@142182|Gemmatimonadetes	142182|Gemmatimonadetes	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
SHD1_k127_3756660_2	861299.J421_1484	1.029e-60	215.0	COG0577@1|root,COG0577@2|Bacteria	861299.J421_1484|-	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_3756660_0	861299.J421_4223	2.99e-97	342.0	COG0531@1|root,COG0531@2|Bacteria,1ZSZK@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
SHD1_k127_3756660_1	861299.J421_1921	2.565e-87	313.0	COG0642@1|root,COG2205@2|Bacteria	861299.J421_1921|-	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_3756660_3	1303518.CCALI_00307	2.953e-59	214.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	nosZ	-	1.1.9.1,1.7.2.4	ko:K00376,ko:K02305,ko:K17760	ko00910,ko01120,map00910,map01120	M00529	R00294,R02804	RC02794,RC02861	ko00000,ko00001,ko00002,ko01000	3.D.4.10	-	-	Beta_helix,Cupredoxin_1,Cytochrom_C,Cytochrome_CBB3,DUF1080,GSDH,HupE_UreJ_2,PSCyt1
SHD1_k127_3756660_4	1122223.KB890700_gene2116	4.074e-33	129.0	COG2132@1|root,COG2132@2|Bacteria,1WJQI@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	Q	Multicopper oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3
SHD1_k127_3768375_2	861299.J421_4449	3.38e-156	506.0	COG0515@1|root,COG0515@2|Bacteria,1ZTFJ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Serine/Threonine protein kinases, catalytic domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
SHD1_k127_3768375_0	861299.J421_4450	0.0	1296.0	COG0466@1|root,COG0466@2|Bacteria,1ZTCH@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
SHD1_k127_3768375_3	379066.GAU_3378	7.779e-38	152.0	2DCAE@1|root,2ZDF3@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_3768375_1	861299.J421_4452	1.474e-230	729.0	COG0744@1|root,COG0744@2|Bacteria,1ZSRR@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	Transglycosylase	-	-	2.4.1.129,3.4.16.4	ko:K21464	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
SHD1_k127_3772852_2	1379270.AUXF01000005_gene668	1.912e-07	53.0	COG0643@1|root,COG0643@2|Bacteria,1ZT7R@142182|Gemmatimonadetes	142182|Gemmatimonadetes	NT	P2 response regulator binding domain	-	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,P2
SHD1_k127_3772852_1	861299.J421_3056	7.463e-44	168.0	COG1776@1|root,COG1776@2|Bacteria,1ZTIW@142182|Gemmatimonadetes	142182|Gemmatimonadetes	NT	CheC-like family	-	-	-	ko:K03410	ko02030,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheC
SHD1_k127_3772852_0	379066.GAU_1408	1.856e-66	241.0	COG0457@1|root,COG0457@2|Bacteria,1ZSS6@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_8
SHD1_k127_3777343_1	861299.J421_5794	2.002e-127	423.0	COG0515@1|root,COG0515@2|Bacteria,1ZUMJ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase
SHD1_k127_3777343_0	1379270.AUXF01000002_gene1586	3.128e-189	623.0	COG0515@1|root,COG0515@2|Bacteria	1379270.AUXF01000002_gene1586|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_3777343_2	861299.J421_5701	2.99e-98	336.0	COG3391@1|root,COG3391@2|Bacteria,1ZUFZ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_3777343_3	886293.Sinac_4160	2.137e-36	149.0	COG0071@1|root,COG0071@2|Bacteria,2J11X@203682|Planctomycetes	203682|Planctomycetes	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
SHD1_k127_3788273_0	1379270.AUXF01000001_gene2467	7.802e-171	547.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1ZT1A@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Enoyl-CoA hydratase/isomerase	fadJ	-	1.1.1.35,4.2.1.17,5.1.2.3	ko:K01782	ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212	M00032,M00087	R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094	RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
SHD1_k127_3788273_2	861299.J421_0342	3.658e-57	220.0	COG0642@1|root,COG2205@2|Bacteria,1ZUZJ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
SHD1_k127_3788273_1	861299.J421_0341	9.974e-79	273.0	COG0745@1|root,COG0745@2|Bacteria,1ZUFQ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
SHD1_k127_3797312_4	861299.J421_3600	6.976e-16	79.0	296W8@1|root,2ZU51@2|Bacteria,1ZU4Z@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_3797312_0	861299.J421_3601	8.77e-250	775.0	COG1260@1|root,COG1260@2|Bacteria,1ZT2X@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Myo-inositol-1-phosphate synthase	-	-	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth,NAD_binding_5
SHD1_k127_3797312_2	379066.GAU_1998	5.333e-76	262.0	COG0558@1|root,COG0558@2|Bacteria,1ZTIP@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	CDP-alcohol phosphatidyltransferase	-	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
SHD1_k127_3797312_1	1121946.AUAX01000032_gene475	6.555e-113	381.0	COG0076@1|root,COG0076@2|Bacteria,2GK3J@201174|Actinobacteria,4DDJQ@85008|Micromonosporales	201174|Actinobacteria	E	Pyridoxal-dependent decarboxylase conserved domain	-	-	1.14.13.9,4.1.1.105,4.1.1.28	ko:K00486,ko:K01593	ko00350,ko00360,ko00380,ko00901,ko00950,ko00965,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00350,map00360,map00380,map00901,map00950,map00965,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00037,M00038,M00042	R00685,R00699,R00736,R01960,R02080,R02701,R04909	RC00046,RC00299	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyridoxal_deC
SHD1_k127_3798229_1	861299.J421_2489	1.208e-85	302.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	ko:K00786	-	-	-	-	ko00000,ko01000	-	-	-	GFO_IDH_MocA,Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
SHD1_k127_3798229_0	396588.Tgr7_2376	1.043e-87	303.0	COG3919@1|root,COG3919@2|Bacteria,1R94Z@1224|Proteobacteria,1RQ74@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	ATP-grasp	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_3,LMWPc
SHD1_k127_3798229_3	1121472.AQWN01000005_gene2363	3.285e-13	82.0	COG0726@1|root,COG0726@2|Bacteria,1V6AW@1239|Firmicutes,24EU8@186801|Clostridia,261SN@186807|Peptococcaceae	186801|Clostridia	G	PFAM Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
SHD1_k127_3798229_2	379066.GAU_0565	1.591e-38	160.0	COG3307@1|root,COG3307@2|Bacteria,1ZV35@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	O-Antigen ligase	-	-	-	-	-	-	-	-	-	-	-	-	Wzy_C
SHD1_k127_3805944_1	379066.GAU_1706	1.22e-170	544.0	COG3185@1|root,COG3185@2|Bacteria,1ZT5D@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Acyclic terpene utilisation family protein AtuA	-	-	-	-	-	-	-	-	-	-	-	-	AtuA
SHD1_k127_3805944_0	861299.J421_3346	1.089e-271	849.0	COG4799@1|root,COG4799@2|Bacteria,1ZTGB@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Carboxyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Carboxyl_trans
SHD1_k127_3805944_3	861299.J421_3347	4.299e-68	236.0	COG2185@1|root,COG2185@2|Bacteria,1ZTNN@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	B12 binding domain	-	-	5.4.99.2	ko:K01849	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding
SHD1_k127_3805944_2	861299.J421_3348	3.28e-124	406.0	COG0500@1|root,COG2226@2|Bacteria,1ZTCQ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
SHD1_k127_3805944_4	1379270.AUXF01000006_gene180	3.885e-29	117.0	COG1884@1|root,COG1884@2|Bacteria,1ZUKS@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Methylmalonyl-CoA mutase	-	-	5.4.99.13,5.4.99.2	ko:K01848,ko:K11942	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
SHD1_k127_3822201_3	762968.HMPREF9441_02009	7.993e-06	53.0	COG0612@1|root,COG0612@2|Bacteria,4NFY0@976|Bacteroidetes,2FMCE@200643|Bacteroidia	976|Bacteroidetes	S	Belongs to the peptidase M16 family	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
SHD1_k127_3822201_1	366649.XFF4834R_chr19630	2.878e-52	190.0	COG3476@1|root,COG3476@2|Bacteria,1MZC1@1224|Proteobacteria,1SCEH@1236|Gammaproteobacteria,1X7CI@135614|Xanthomonadales	135614|Xanthomonadales	T	Tryptophan-rich sensory protein	tspO	-	-	ko:K05770	ko04080,ko04214,ko04979,ko05166,map04080,map04214,map04979,map05166	-	-	-	ko00000,ko00001,ko02000	9.A.24	-	-	TspO_MBR
SHD1_k127_3822201_0	452637.Oter_1367	9.797e-82	279.0	COG0262@1|root,COG0262@2|Bacteria,46XD6@74201|Verrucomicrobia,3K9XY@414999|Opitutae	414999|Opitutae	H	PFAM bifunctional deaminase-reductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
SHD1_k127_3822201_2	1144319.PMI16_02911	4.296e-44	163.0	COG1917@1|root,COG1917@2|Bacteria,1RGXQ@1224|Proteobacteria,2W33Z@28216|Betaproteobacteria,477F0@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_3832636_0	1379270.AUXF01000003_gene3431	2.725e-154	516.0	COG0308@1|root,COG0308@2|Bacteria,1ZUT0@142182|Gemmatimonadetes	2|Bacteria	E	Peptidase family M1 domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1
SHD1_k127_3832636_1	861299.J421_3944	7.662e-41	154.0	COG0712@1|root,COG0712@2|Bacteria,1ZTP8@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	-	-	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	OSCP
SHD1_k127_3849688_1	1382356.JQMP01000001_gene1252	1.57e-117	392.0	COG0437@1|root,COG0437@2|Bacteria,2G9ZX@200795|Chloroflexi,27Y09@189775|Thermomicrobia	189775|Thermomicrobia	C	4Fe-4S binding domain	-	-	-	ko:K00124	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001	-	-	-	Fer4_11,Fer4_3
SHD1_k127_3849688_0	525904.Tter_0612	0.0	1351.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,2NQFR@2323|unclassified Bacteria	2|Bacteria	C	Molydopterin dinucleotide binding domain	fdhA2	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
SHD1_k127_3871242_0	861299.J421_3587	1.988e-211	670.0	COG1027@1|root,COG1027@2|Bacteria,1ZSUY@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Fumarase C C-terminus	-	-	4.3.1.1	ko:K01744	ko00250,ko01100,map00250,map01100	-	R00490	RC00316,RC02799	ko00000,ko00001,ko01000	-	-	-	FumaraseC_C,Lyase_1
SHD1_k127_3871242_1	204669.Acid345_1838	1.405e-09	61.0	COG2128@1|root,COG2128@2|Bacteria	2|Bacteria	S	hydroperoxide reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
SHD1_k127_3881643_1	379066.GAU_1544	5.811e-108	360.0	COG5000@1|root,COG5000@2|Bacteria,1ZSKZ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
SHD1_k127_3881643_0	351627.Csac_1456	2.713e-131	440.0	COG0172@1|root,COG0172@2|Bacteria,1TP4W@1239|Firmicutes,2485M@186801|Clostridia,42EYY@68295|Thermoanaerobacterales	186801|Clostridia	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
SHD1_k127_3881643_2	861299.J421_3174	2.878e-13	77.0	2FES0@1|root,346R1@2|Bacteria,1ZU3X@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_3913420_7	861299.J421_3118	3.446e-39	147.0	COG0781@1|root,COG0781@2|Bacteria,1ZTRU@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
SHD1_k127_3913420_2	861299.J421_3119	1.537e-162	520.0	COG0438@1|root,COG0438@2|Bacteria,1ZTBC@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
SHD1_k127_3913420_3	861299.J421_3121	1.344e-114	378.0	COG1493@1|root,COG1493@2|Bacteria,1ZSY3@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr)	hprK	-	-	ko:K06023	-	-	-	-	ko00000,ko01000	-	-	-	Hpr_kinase_C,Hpr_kinase_N
SHD1_k127_3913420_10	1379270.AUXF01000005_gene731	1.36e-05	50.0	COG2893@1|root,COG2893@2|Bacteria,1ZU41@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	PTS system fructose IIA component	-	-	-	ko:K02744	ko00052,ko02060,map00052,map02060	M00277,M00287	R08366,R08367	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.6.1.4,4.A.6.1.5	-	-	EIIA-man
SHD1_k127_3913420_9	1379270.AUXF01000005_gene731	1.919e-10	64.0	COG2893@1|root,COG2893@2|Bacteria,1ZU41@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	PTS system fructose IIA component	-	-	-	ko:K02744	ko00052,ko02060,map00052,map02060	M00277,M00287	R08366,R08367	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.6.1.4,4.A.6.1.5	-	-	EIIA-man
SHD1_k127_3913420_6	1379270.AUXF01000005_gene732	2.112e-60	213.0	COG3444@1|root,COG3444@2|Bacteria,1ZTQR@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	PTS system sorbose subfamily IIB component	-	-	-	ko:K19507	ko02060,map02060	M00764	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.6.1.19	-	-	PTSIIB_sorb
SHD1_k127_3913420_5	861299.J421_3124	2.04e-63	224.0	COG3715@1|root,COG3715@2|Bacteria,1ZTVH@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	PTS system sorbose-specific iic component	-	-	-	ko:K02795	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	M00276	R02630	RC00017,RC03206	ko00000,ko00001,ko00002,ko02000	4.A.6.1	-	-	EII-Sor
SHD1_k127_3913420_4	861299.J421_3125	2.851e-74	269.0	COG3716@1|root,COG3716@2|Bacteria,1ZTJH@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	PTS system mannose/fructose/sorbose family IID component	-	-	-	ko:K02796	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	M00276	R02630	RC00017,RC03206	ko00000,ko00001,ko00002,ko02000	4.A.6.1	-	-	EIID-AGA
SHD1_k127_3913420_8	1379270.AUXF01000005_gene735	3.25e-31	132.0	COG1925@1|root,COG1925@2|Bacteria,1ZTYE@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	PTS HPr component phosphorylation site	-	-	-	ko:K11189	-	-	-	-	ko00000,ko02000	4.A.2.1	-	-	PTS-HPr
SHD1_k127_3913420_0	861299.J421_3127	1.796e-244	771.0	COG1080@1|root,COG1080@2|Bacteria,1ZT3W@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	-	-	2.7.3.9	ko:K08483	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	8.A.7	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
SHD1_k127_3913420_1	861299.J421_3128	1.202e-164	524.0	COG0192@1|root,COG0192@2|Bacteria,1ZSZ9@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
SHD1_k127_3922471_0	861299.J421_4440	2.665e-128	419.0	COG2876@1|root,COG2876@2|Bacteria,1ZSPH@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	NeuB family	-	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
SHD1_k127_3922471_1	861299.J421_6150	4.672e-29	124.0	2DF6S@1|root,2ZQP7@2|Bacteria,1ZU7F@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_3922471_2	195250.CM001776_gene1693	1.263e-21	98.0	COG0640@1|root,COG0640@2|Bacteria,1G8TK@1117|Cyanobacteria	1117|Cyanobacteria	K	ArsR family transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
SHD1_k127_3932665_2	861299.J421_1938	3.223e-06	51.0	COG0642@1|root,COG2205@2|Bacteria,1ZUG2@142182|Gemmatimonadetes	861299.J421_1938|-	T	Domain of unknown function (DUF4118)	-	-	2.7.13.3	ko:K07646	ko02020,map02020	M00454	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	-
SHD1_k127_3932665_1	861299.J421_1888	8.489e-81	276.0	COG0745@1|root,COG0745@2|Bacteria,1ZUUR@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Transcriptional regulatory protein, C terminal	-	-	-	ko:K07667	ko02020,ko02024,map02020,map02024	M00454	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
SHD1_k127_3932665_0	869210.Marky_1224	7.986e-210	659.0	COG2224@1|root,COG2224@2|Bacteria,1WI8Z@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Isocitrate lyase	aceA	-	4.1.3.1	ko:K01637	ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200	M00012	R00479	RC00311,RC00313	ko00000,ko00001,ko00002,ko01000	-	-	-	ICL
SHD1_k127_3938284_0	1379270.AUXF01000005_gene811	5.526e-285	895.0	COG0210@1|root,COG0210@2|Bacteria,1ZTD5@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	UvrD-like helicase C-terminal domain	-	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
SHD1_k127_3938284_4	861299.J421_3178	7.965e-21	106.0	COG0721@1|root,COG0721@2|Bacteria,1ZU4T@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	-	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Glu-tRNAGln
SHD1_k127_3938284_2	246194.CHY_1102	5.099e-145	477.0	COG0154@1|root,COG0154@2|Bacteria,1TP0C@1239|Firmicutes,24911@186801|Clostridia,42EXF@68295|Thermoanaerobacterales	186801|Clostridia	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
SHD1_k127_3938284_1	861299.J421_3180	1.29e-190	610.0	COG0064@1|root,COG0064@2|Bacteria,1ZTCB@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	-	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
SHD1_k127_3938284_3	1379270.AUXF01000005_gene815	2.333e-122	399.0	28Q1P@1|root,2ZB8E@2|Bacteria,1ZSPA@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Zinc dependent phospholipase C	-	-	-	-	-	-	-	-	-	-	-	-	Zn_dep_PLPC
SHD1_k127_393938_6	1382359.JIAL01000001_gene2986	3.031e-08	56.0	2DBA6@1|root,2Z814@2|Bacteria,3Y3NI@57723|Acidobacteria,2JKXA@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_393938_0	861299.J421_3478	5.248e-132	429.0	COG2870@1|root,COG2870@2|Bacteria,1ZT0S@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	pfkB family carbohydrate kinase	-	-	2.7.1.167,2.7.7.70	ko:K03272	ko00540,ko01100,map00540,map01100	M00064	R05644,R05646	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	PfkB
SHD1_k127_393938_1	861299.J421_3477	1.485e-108	359.0	COG0767@1|root,COG0767@2|Bacteria,1ZUC4@142182|Gemmatimonadetes	142182|Gemmatimonadetes	Q	Permease MlaE	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
SHD1_k127_393938_2	861299.J421_3476	7.867e-105	362.0	COG1127@1|root,COG1127@2|Bacteria,1ZT5N@142182|Gemmatimonadetes	2|Bacteria	Q	ABC transporter	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
SHD1_k127_393938_3	861299.J421_3475	1.544e-104	349.0	COG1463@1|root,COG1463@2|Bacteria	2|Bacteria	Q	ABC-type transport system involved in resistance to organic solvents, periplasmic component	ttg2C	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
SHD1_k127_393938_4	1379270.AUXF01000006_gene55	6.971e-50	183.0	COG0697@1|root,COG0697@2|Bacteria,1ZUKF@142182|Gemmatimonadetes	142182|Gemmatimonadetes	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
SHD1_k127_3948060_8	671143.DAMO_0272	8.852e-14	78.0	COG0859@1|root,COG3307@1|root,COG0859@2|Bacteria,COG3307@2|Bacteria,2NP5P@2323|unclassified Bacteria	2|Bacteria	M	Glycosyl transferase, family 9	rfaQ	-	-	ko:K02841,ko:K02843,ko:K02847,ko:K02849,ko:K21003	ko00540,ko01100,ko02025,map00540,map01100,map02025	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005,ko02000	9.B.67.4,9.B.67.5	GT9	-	Glyco_transf_25,Glyco_transf_9,Wzy_C
SHD1_k127_3948060_1	861299.J421_3870	4.008e-132	432.0	COG0859@1|root,COG0859@2|Bacteria,1ZT3G@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	ko:K12982	-	-	-	-	ko00000,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
SHD1_k127_3948060_3	379066.GAU_2420	2.704e-66	233.0	COG0424@1|root,COG0424@2|Bacteria,1ZTP7@142182|Gemmatimonadetes	142182|Gemmatimonadetes	D	Maf-like protein	-	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
SHD1_k127_3948060_5	1121346.KB899811_gene1646	1.407e-48	177.0	COG1490@1|root,COG1490@2|Bacteria,1V6GH@1239|Firmicutes,4HINN@91061|Bacilli,26XEB@186822|Paenibacillaceae	91061|Bacilli	J	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality	dtd	GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360	-	ko:K07560	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Tyr_Deacylase
SHD1_k127_3948060_7	234267.Acid_2639	5.272e-25	110.0	COG0454@1|root,COG0456@2|Bacteria,3Y5G1@57723|Acidobacteria	57723|Acidobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
SHD1_k127_3948060_4	234267.Acid_5195	1.776e-59	211.0	2EHG8@1|root,33B84@2|Bacteria,3Y808@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_3948060_2	926560.KE387027_gene263	8.591e-79	274.0	COG2120@1|root,COG2120@2|Bacteria	2|Bacteria	S	N-acetylglucosaminylinositol deacetylase activity	-	-	-	ko:K22135	-	-	-	-	ko00000,ko01000	-	-	-	PIG-L
SHD1_k127_3948060_0	502025.Hoch_4339	4.929e-156	508.0	COG0076@1|root,COG0076@2|Bacteria,1MWUX@1224|Proteobacteria,42MYA@68525|delta/epsilon subdivisions,2WKFB@28221|Deltaproteobacteria,2YWPS@29|Myxococcales	28221|Deltaproteobacteria	E	Pyridoxal-dependent decarboxylase conserved domain	-	-	-	-	-	-	-	-	-	-	-	-	Pyridoxal_deC
SHD1_k127_3948060_6	883078.HMPREF9695_01001	2.4e-40	154.0	COG1917@1|root,COG1917@2|Bacteria,1MZF9@1224|Proteobacteria,2U63E@28211|Alphaproteobacteria,3K009@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_1,Cupin_2,Cupin_7,DUF4437
SHD1_k127_395953_1	1408254.T458_20120	4.971e-53	194.0	COG1216@1|root,COG1216@2|Bacteria,1VE3R@1239|Firmicutes,4IPM4@91061|Bacilli,26S02@186822|Paenibacillaceae	91061|Bacilli	S	Glycosyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
SHD1_k127_395953_0	1379270.AUXF01000002_gene1600	6.804e-93	321.0	COG0515@1|root,COG0515@2|Bacteria	1379270.AUXF01000002_gene1600|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_3978861_2	861299.J421_2409	2.758e-48	173.0	COG1845@1|root,COG1845@2|Bacteria,1ZT8Q@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Cytochrome c oxidase subunit III	-	-	1.9.3.1	ko:K02276,ko:K02299	ko00190,ko01100,map00190,map01100	M00155,M00417	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.5,3.D.4.6	-	-	COX3
SHD1_k127_3978861_3	861299.J421_2410	1.095e-30	126.0	2EKS3@1|root,33EFV@2|Bacteria,1ZTY7@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Prokaryotic Cytochrome C oxidase subunit IV	-	-	1.9.3.1	ko:K02277	ko00190,ko01100,map00190,map01100	M00155	-	-	ko00000,ko00001,ko00002,ko01000	3.D.4.4	-	-	COX4_pro
SHD1_k127_3978861_0	861299.J421_2402	1.426e-136	446.0	COG4299@1|root,COG4299@2|Bacteria,1ZT4E@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	COGs COG4299 conserved	-	-	-	-	-	-	-	-	-	-	-	-	DUF5009
SHD1_k127_3978861_1	1379270.AUXF01000002_gene1833	5.804e-105	356.0	COG2027@1|root,COG2027@2|Bacteria,1ZT1Q@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	D-Ala-D-Ala carboxypeptidase 3 (S13) family	-	-	3.4.16.4	ko:K07259	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	Peptidase_S13
SHD1_k127_3984132_1	504728.K649_08065	9.058e-48	178.0	COG1926@1|root,COG1926@2|Bacteria,1WKAM@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Phosphoribosyl transferase domain	-	-	-	ko:K07100	-	-	-	-	ko00000	-	-	-	Pribosyltran
SHD1_k127_3984132_2	1298858.AUEL01000002_gene1505	8.812e-42	161.0	COG3554@1|root,COG3554@2|Bacteria,1RA4K@1224|Proteobacteria,2VGHQ@28211|Alphaproteobacteria,43PS7@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Putative glycolipid-binding	-	-	-	ko:K09957	-	-	-	-	ko00000	-	-	-	Glycolipid_bind
SHD1_k127_3984132_0	861299.J421_4236	1.538e-71	244.0	COG2957@1|root,COG2957@2|Bacteria,1ZSZ0@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Porphyromonas-type peptidyl-arginine deiminase	-	-	3.5.3.12	ko:K10536	ko00330,ko01100,map00330,map01100	-	R01416	RC00177	ko00000,ko00001,ko01000	-	-	-	PAD_porph
SHD1_k127_3990112_3	861299.J421_2677	1.12e-120	409.0	COG4775@1|root,COG4775@2|Bacteria,1ZTG1@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_3990112_0	379066.GAU_0756	2.744e-197	627.0	COG3104@1|root,COG3104@2|Bacteria,1ZSRG@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	POT family	-	-	-	ko:K03305	-	-	-	-	ko00000	2.A.17	-	-	PTR2
SHD1_k127_3990112_2	861299.J421_2679	3.911e-148	488.0	COG4608@1|root,COG4608@2|Bacteria,1ZSTB@142182|Gemmatimonadetes	142182|Gemmatimonadetes	P	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
SHD1_k127_3990112_1	861299.J421_2680	1.591e-150	482.0	COG0444@1|root,COG0444@2|Bacteria,1ZSWI@142182|Gemmatimonadetes	142182|Gemmatimonadetes	P	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
SHD1_k127_3990112_4	243231.GSU1435	2.884e-75	261.0	COG1173@1|root,COG1173@2|Bacteria,1MU26@1224|Proteobacteria,42MFP@68525|delta/epsilon subdivisions,2WJ47@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
SHD1_k127_4000224_1	1379270.AUXF01000003_gene3634	2.198e-172	551.0	COG2234@1|root,COG2234@2|Bacteria,1ZUGS@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
SHD1_k127_4000224_7	861299.J421_0770	9.71e-39	153.0	COG1846@1|root,COG1846@2|Bacteria,1ZU5M@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR
SHD1_k127_4000224_5	379066.GAU_3295	2.608e-59	211.0	COG2259@1|root,COG2259@2|Bacteria	2|Bacteria	S	methylamine metabolic process	doxD	-	-	ko:K15977	-	-	-	-	ko00000	-	-	-	DoxX
SHD1_k127_4000224_2	420324.KI911956_gene3390	3.551e-161	519.0	COG2141@1|root,COG2141@2|Bacteria,1MUTJ@1224|Proteobacteria,2TTZI@28211|Alphaproteobacteria,1JU1Z@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
SHD1_k127_4000224_4	861299.J421_2212	4.653e-62	241.0	COG0742@1|root,COG0742@2|Bacteria,1ZTNJ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	Conserved hypothetical protein 95	-	-	2.1.1.171	ko:K08316	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Cons_hypoth95
SHD1_k127_4000224_0	861299.J421_0783	2.642e-187	601.0	COG5002@1|root,COG5002@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_9,Response_reg
SHD1_k127_4000224_3	861299.J421_1083	3.315e-76	261.0	COG0577@1|root,COG0577@2|Bacteria	861299.J421_1083|-	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_4001743_2	861299.J421_3092	9.185e-39	148.0	COG1694@1|root,COG3956@2|Bacteria,1ZSZH@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	MazG nucleotide pyrophosphohydrolase domain	-	-	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	MazG
SHD1_k127_4001743_0	861299.J421_3089	1.329e-211	664.0	COG0017@1|root,COG0017@2|Bacteria,1ZSTX@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	tRNA synthetases class II (D, K and N)	asnS	-	6.1.1.22	ko:K01893	ko00970,map00970	M00359,M00360	R03648	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
SHD1_k127_4001743_1	861299.J421_3088	4.732e-121	406.0	COG5002@1|root,COG5002@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9
SHD1_k127_4009313_0	1379270.AUXF01000005_gene661	3.565e-294	918.0	COG0060@1|root,COG0060@2|Bacteria,1ZSKS@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
SHD1_k127_4009313_2	861299.J421_3049	2.376e-68	235.0	COG1734@1|root,COG1734@2|Bacteria,1ZTP9@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	Prokaryotic dksA/traR C4-type zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-dskA_traR
SHD1_k127_4009313_3	861299.J421_3050	7.807e-52	192.0	COG0597@1|root,COG0597@2|Bacteria,1ZTWA@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	-	-	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
SHD1_k127_4009313_1	1379270.AUXF01000005_gene665	3.263e-136	441.0	COG0564@1|root,COG0564@2|Bacteria,1ZSXN@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Responsible for synthesis of pseudouridine from uracil	-	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
SHD1_k127_4034817_1	1379270.AUXF01000005_gene589	3.021e-84	287.0	COG0525@1|root,COG0525@2|Bacteria,1ZSXQ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
SHD1_k127_4034817_3	379066.GAU_1282	1.498e-68	253.0	COG2372@1|root,COG2372@2|Bacteria,1ZTUI@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Bacterial Ig-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Big_5
SHD1_k127_4034817_5	861299.J421_2991	9.07e-52	197.0	COG0241@1|root,COG0241@2|Bacteria,1ZTT8@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	HAD-hyrolase-like	-	-	3.1.3.82,3.1.3.83	ko:K03273	ko00540,ko01100,map00540,map01100	M00064	R05647,R09771	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hydrolase_like
SHD1_k127_4034817_4	861299.J421_2990	8.931e-57	205.0	COG0299@1|root,COG0299@2|Bacteria,1ZTKJ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	purN	-	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	Formyl_trans_N
SHD1_k127_4034817_0	1379270.AUXF01000005_gene585	6.358e-159	507.0	COG0138@1|root,COG0138@2|Bacteria,1ZT6N@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	AICARFT/IMPCHase bienzyme	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
SHD1_k127_4034817_2	1379270.AUXF01000005_gene585	1.173e-70	242.0	COG0138@1|root,COG0138@2|Bacteria,1ZT6N@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	AICARFT/IMPCHase bienzyme	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
SHD1_k127_4051089_0	406817.XNC1_2156	6.82e-85	299.0	COG1022@1|root,COG3321@1|root,COG1022@2|Bacteria,COG3321@2|Bacteria,1R89Z@1224|Proteobacteria,1SMTI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	polyketide synthase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N_2,AMP-binding,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
SHD1_k127_4053839_6	861299.J421_3272	1.619e-107	365.0	COG0332@1|root,COG0332@2|Bacteria,1ZSP4@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	-	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
SHD1_k127_4053839_5	861299.J421_3273	2.658e-122	402.0	COG0416@1|root,COG0416@2|Bacteria,1ZSN4@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA	plsX	-	2.3.1.15	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_synthesis
SHD1_k127_4053839_12	861299.J421_3274	3.327e-25	105.0	COG0333@1|root,COG0333@2|Bacteria,1ZU2M@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Ribosomal L32p protein family	rpmF	-	-	ko:K02911	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_L32p
SHD1_k127_4053839_9	861299.J421_3275	1.147e-55	200.0	COG1399@1|root,COG1399@2|Bacteria,1ZTSW@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Uncharacterized ACR, COG1399	-	-	-	ko:K07040	-	-	-	-	ko00000	-	-	-	DUF177
SHD1_k127_4053839_10	1379270.AUXF01000006_gene247	3.656e-54	195.0	COG0105@1|root,COG0105@2|Bacteria,1ZTTD@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	NDK	-	-	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
SHD1_k127_4053839_7	861299.J421_3277	4.467e-92	314.0	COG0517@1|root,COG1762@1|root,COG0517@2|Bacteria,COG1762@2|Bacteria,1ZUGZ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	GT	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2	-	-	-	-	-	-	-	-	-	-	-	-	CBS,PTS_EIIA_2
SHD1_k127_4053839_2	379066.GAU_1645	4.891e-149	477.0	COG0074@1|root,COG0074@2|Bacteria,1ZT20@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA
SHD1_k127_4053839_1	1379270.AUXF01000006_gene245	1.609e-178	566.0	COG0045@1|root,COG0045@2|Bacteria,1ZSZ4@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
SHD1_k127_4053839_8	880073.Calab_0632	1.525e-71	265.0	COG0549@1|root,COG0549@2|Bacteria,2NNKM@2323|unclassified Bacteria	2|Bacteria	E	Amino acid kinase family	arcC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008804,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019546,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	2.7.2.2	ko:K00926	ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200	-	R00150,R01395	RC00002,RC00043,RC02803,RC02804	ko00000,ko00001,ko01000	-	-	iAPECO1_1312.APECO1_3652,iE2348C_1286.E2348C_0454,iECABU_c1320.ECABU_c31550,iECED1_1282.ECED1_0540,iECED1_1282.ECED1_3334,iECIAI39_1322.ECIAI39_3289,iECNA114_1301.ECNA114_2915,iECOK1_1307.ECOK1_3260,iECS88_1305.ECS88_3153,iECSF_1327.ECSF_2670,iECUMN_1333.ECUMN_0561,iEcE24377_1341.EcE24377A_0559,iG2583_1286.G2583_0641,iHN637.CLJU_RS13830,iJN746.PP_0999,iUMN146_1321.UM146_02150,iUTI89_1310.UTI89_C3259,ic_1306.c3452	AA_kinase
SHD1_k127_4053839_4	861299.J421_3280	1.842e-138	470.0	COG1615@1|root,COG1615@2|Bacteria,1ZTEE@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Uncharacterised protein family (UPF0182)	-	-	-	ko:K09118	-	-	-	-	ko00000	-	-	-	UPF0182
SHD1_k127_4053839_0	379066.GAU_1648	1.707e-215	677.0	COG1109@1|root,COG1109@2|Bacteria,1ZSP6@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	Phosphoglucomutase/phosphomannomutase, C-terminal domain	-	-	5.4.2.2,5.4.2.8	ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
SHD1_k127_4053839_3	861299.J421_3282	7.669e-143	469.0	COG1007@1|root,COG1007@2|Bacteria,1ZSVJ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
SHD1_k127_4053839_11	1379698.RBG1_1C00001G1061	6.622e-54	194.0	COG1008@1|root,COG1008@2|Bacteria,2NNQ9@2323|unclassified Bacteria	2|Bacteria	C	NADH-quinone oxidoreductase, chain M	nuoM-1	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q5_N,Proton_antipo_M
SHD1_k127_4056575_8	861299.J421_4104	1.142e-54	208.0	COG5492@1|root,COG5492@2|Bacteria,1ZUE7@142182|Gemmatimonadetes	142182|Gemmatimonadetes	N	Bacterial Ig-like domain 2	-	-	-	-	-	-	-	-	-	-	-	-	Big_2
SHD1_k127_4056575_9	903818.KI912268_gene1340	1.544e-19	96.0	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
SHD1_k127_4056575_10	485913.Krac_1228	7.885e-11	74.0	COG1276@1|root,COG2372@1|root,COG1276@2|Bacteria,COG2372@2|Bacteria	2|Bacteria	C	response to copper ion	-	-	-	ko:K07156,ko:K07245,ko:K14166	-	-	-	-	ko00000,ko02000	9.B.62.1,9.B.62.2	-	-	CopC,CopD,YtkA
SHD1_k127_4056575_4	1379270.AUXF01000002_gene1629	4.63e-98	336.0	COG1131@1|root,COG1131@2|Bacteria,1ZT45@142182|Gemmatimonadetes	142182|Gemmatimonadetes	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SHD1_k127_4056575_6	861299.J421_0236	1.407e-81	293.0	29YN3@1|root,30KHK@2|Bacteria,1ZT0C@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Putative ABC exporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_export
SHD1_k127_4056575_2	1521187.JPIM01000061_gene1009	1.038e-174	569.0	COG0531@1|root,COG0531@2|Bacteria,2G5ZF@200795|Chloroflexi,37597@32061|Chloroflexia	32061|Chloroflexia	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
SHD1_k127_4056575_11	1161401.ASJA01000011_gene1484	1.813e-07	63.0	COG0642@1|root,COG2205@2|Bacteria,1MVY8@1224|Proteobacteria,2TS5B@28211|Alphaproteobacteria,43WPK@69657|Hyphomonadaceae	28211|Alphaproteobacteria	T	Tyrosine kinase	divL	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_7,PAS_8
SHD1_k127_4056575_3	379066.GAU_2894	1.639e-151	493.0	COG0642@1|root,COG2205@2|Bacteria	379066.GAU_2894|-	T	PhoQ Sensor	-	-	2.7.13.3	ko:K07646	ko02020,map02020	M00454	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	-
SHD1_k127_4056575_5	1379270.AUXF01000002_gene1845	2.88e-88	310.0	2CB8G@1|root,2Z88H@2|Bacteria,1ZV93@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Putative beta-barrel porin-2, OmpL-like. bbp2	-	-	-	-	-	-	-	-	-	-	-	-	BBP2
SHD1_k127_4056575_7	379066.GAU_2892	1.263e-57	206.0	COG2156@1|root,COG2156@2|Bacteria	2|Bacteria	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex	kdpC	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044425,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132	3.6.3.12	ko:K01548	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	-	KdpC
SHD1_k127_4056575_0	204669.Acid345_0511	1.706e-301	944.0	COG2216@1|root,COG2216@2|Bacteria,3Y302@57723|Acidobacteria,2JHQI@204432|Acidobacteriia	204432|Acidobacteriia	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system	kdpB	-	3.6.3.12	ko:K01547	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	-	E1-E2_ATPase,Hydrolase
SHD1_k127_4056575_1	1380394.JADL01000007_gene4503	2.854e-187	595.0	COG2060@1|root,COG2060@2|Bacteria,1MV1K@1224|Proteobacteria,2TSIJ@28211|Alphaproteobacteria,2JPJD@204441|Rhodospirillales	204441|Rhodospirillales	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane	kdpA	-	3.6.3.12	ko:K01546	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	-	KdpA
SHD1_k127_4058986_1	861299.J421_1984	3.561e-60	217.0	COG1102@1|root,COG1102@2|Bacteria	2|Bacteria	F	Psort location Cytoplasmic, score	-	-	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin2
SHD1_k127_4058986_0	1242864.D187_005732	1.559e-80	276.0	COG0702@1|root,COG0702@2|Bacteria,1QR3E@1224|Proteobacteria,4341F@68525|delta/epsilon subdivisions,2X4MP@28221|Deltaproteobacteria,2YZ9G@29|Myxococcales	28221|Deltaproteobacteria	GM	epimerase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
SHD1_k127_4058986_2	485913.Krac_4005	1.204e-34	141.0	COG2041@1|root,COG2041@2|Bacteria,2G6ES@200795|Chloroflexi	200795|Chloroflexi	S	PFAM oxidoreductase, molybdopterin binding	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_molyb
SHD1_k127_4062826_2	861299.J421_2647	2.829e-22	97.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,Plug,TonB_dep_Rec
SHD1_k127_4062826_0	861299.J421_2647	2.666e-232	755.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,Plug,TonB_dep_Rec
SHD1_k127_4062826_1	861299.J421_2646	4.126e-63	247.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_4062826_3	861299.J421_0341	8.108e-11	62.0	COG0745@1|root,COG0745@2|Bacteria,1ZUFQ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
SHD1_k127_406728_2	379066.GAU_1983	2.284e-68	235.0	COG1959@1|root,COG1959@2|Bacteria,1ZTRG@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
SHD1_k127_406728_7	861299.J421_3585	2.738e-44	172.0	2FH4R@1|root,348ZA@2|Bacteria,1ZU3S@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_406728_3	861299.J421_3584	2.354e-64	224.0	COG0691@1|root,COG0691@2|Bacteria,1ZTQN@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA	smpB	-	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
SHD1_k127_406728_1	1379270.AUXF01000003_gene3876	1.36e-101	347.0	COG0860@1|root,COG0860@2|Bacteria,1ZSUX@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	Ami_3	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_3
SHD1_k127_406728_0	861299.J421_3582	9.766e-118	386.0	COG0167@1|root,COG0167@2|Bacteria,1ZT86@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily	pyrD	-	1.3.1.14	ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
SHD1_k127_406728_4	1379270.AUXF01000003_gene3879	1.284e-61	230.0	COG0284@1|root,COG0284@2|Bacteria,1ZTQS@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)	pyrF	-	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
SHD1_k127_406728_8	1157490.EL26_18740	9.608e-39	148.0	COG0346@1|root,COG0346@2|Bacteria,1VAEF@1239|Firmicutes,4HGTX@91061|Bacilli,27A1F@186823|Alicyclobacillaceae	91061|Bacilli	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
SHD1_k127_406728_9	861299.J421_3580	3.299e-16	79.0	COG0257@1|root,COG0257@2|Bacteria,1ZVAA@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Ribosomal protein L36	rpmJ	-	-	ko:K02919	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L36
SHD1_k127_406728_5	1379270.AUXF01000003_gene3880	2.304e-61	213.0	COG0099@1|root,COG0099@2|Bacteria,1ZTNX@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	-	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
SHD1_k127_406728_6	1379270.AUXF01000003_gene3881	2.406e-59	209.0	COG0100@1|root,COG0100@2|Bacteria,1ZTMZ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome	rpsK	-	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
SHD1_k127_4070936_0	661478.OP10G_1347	1.009e-232	752.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR,Sortilin-Vps10
SHD1_k127_4070936_1	1191523.MROS_2208	5.238e-81	297.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	irp	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
SHD1_k127_4070936_3	633149.Bresu_3187	1.979e-06	56.0	COG0624@1|root,COG0624@2|Bacteria,1MWJS@1224|Proteobacteria,2TUHT@28211|Alphaproteobacteria,2KFBQ@204458|Caulobacterales	204458|Caulobacterales	E	Peptidase, M20	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
SHD1_k127_4070936_2	1382359.JIAL01000001_gene2356	8.81e-73	254.0	COG3186@1|root,COG3186@2|Bacteria,3Y3K5@57723|Acidobacteria,2JHN0@204432|Acidobacteriia	204432|Acidobacteriia	E	Biopterin-dependent aromatic amino acid hydroxylase	-	-	1.14.16.1	ko:K00500	ko00360,ko00400,ko00790,ko01100,ko01230,map00360,map00400,map00790,map01100,map01230	-	R01795,R07211	RC00490	ko00000,ko00001,ko01000	-	-	-	Biopterin_H
SHD1_k127_4073094_2	661478.OP10G_0721	2.203e-53	196.0	COG0667@1|root,COG0667@2|Bacteria	2|Bacteria	C	Aldo Keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
SHD1_k127_4073094_1	861299.J421_1927	2.299e-102	346.0	COG0845@1|root,COG0845@2|Bacteria,1ZUDM@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	Biotin-lipoyl like	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	HlyD_D23
SHD1_k127_4073094_0	861299.J421_1928	0.0	1194.0	COG0841@1|root,COG0841@2|Bacteria,1ZUMV@142182|Gemmatimonadetes	142182|Gemmatimonadetes	V	MMPL family	-	-	-	ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
SHD1_k127_4079834_3	861299.J421_3765	4.933e-107	358.0	COG0845@1|root,COG0845@2|Bacteria,1ZV43@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	-	-	-	ko:K15727	-	-	-	-	ko00000,ko02000	8.A.1.2.1	-	-	HlyD_D23
SHD1_k127_4079834_4	861299.J421_3764	6.657e-107	363.0	COG1538@1|root,COG1538@2|Bacteria,1ZV8X@142182|Gemmatimonadetes	142182|Gemmatimonadetes	MU	Outer membrane efflux protein	-	-	-	ko:K15725	-	-	-	-	ko00000,ko02000	1.B.17.2.2	-	-	OEP
SHD1_k127_4079834_2	118166.JH976537_gene16	2.485e-121	398.0	COG0500@1|root,COG2226@2|Bacteria,1GQU7@1117|Cyanobacteria,1HHZR@1150|Oscillatoriales	1117|Cyanobacteria	Q	Protein of unknown function (DUF1698)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
SHD1_k127_4079834_1	272134.KB731324_gene4072	2.149e-167	538.0	COG1232@1|root,COG1232@2|Bacteria,1GBRP@1117|Cyanobacteria,1HF96@1150|Oscillatoriales	1117|Cyanobacteria	H	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
SHD1_k127_4079834_6	1379270.AUXF01000001_gene2804	3.304e-39	157.0	COG1853@1|root,COG1853@2|Bacteria,1ZTVB@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Flavin reductase like domain	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
SHD1_k127_4079834_0	404589.Anae109_1015	2.383e-274	859.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,42M2R@68525|delta/epsilon subdivisions,2WJ4J@28221|Deltaproteobacteria,2YTUI@29|Myxococcales	28221|Deltaproteobacteria	P	copper-translocating P-type ATPase	-	-	3.6.3.4	ko:K01533	-	-	R00086	RC00002	ko00000,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hydrolase
SHD1_k127_4079834_5	1267535.KB906767_gene1343	2.883e-41	158.0	COG2085@1|root,COG2085@2|Bacteria,3Y5CN@57723|Acidobacteria,2JNMR@204432|Acidobacteriia	204432|Acidobacteriia	S	NADP oxidoreductase coenzyme F420-dependent	-	-	1.5.1.40	ko:K06988	-	-	-	-	ko00000,ko01000	-	-	-	F420_oxidored
SHD1_k127_4080747_4	396588.Tgr7_3177	3.652e-25	119.0	COG5607@1|root,COG5607@2|Bacteria,1NGVB@1224|Proteobacteria	1224|Proteobacteria	S	PFAM CHAD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CHAD
SHD1_k127_4080747_2	326427.Cagg_0668	3.199e-58	224.0	COG5184@1|root,COG5184@2|Bacteria,2G8WU@200795|Chloroflexi,3765G@32061|Chloroflexia	200795|Chloroflexi	DZ	PFAM regulator of chromosome condensation, RCC1	-	-	-	-	-	-	-	-	-	-	-	-	RCC1,RCC1_2
SHD1_k127_4080747_3	204669.Acid345_3975	1.027e-50	199.0	COG5305@1|root,COG5305@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K14340	-	-	-	-	ko00000,ko01000,ko01003	-	-	-	PMT_2
SHD1_k127_4080747_1	861299.J421_2698	1.76e-129	421.0	COG0454@1|root,COG0454@2|Bacteria,1ZSVU@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
SHD1_k127_4080747_0	861299.J421_2697	1.358e-149	488.0	COG0419@1|root,COG0419@2|Bacteria,1ZTD9@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	AAA domain	-	-	-	ko:K03546	-	-	-	-	ko00000,ko03400	-	-	-	SMC_N
SHD1_k127_4082929_1	926560.KE387023_gene1480	3.39e-283	887.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1WI6E@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
SHD1_k127_4082929_2	269800.Tfu_1746	3.015e-114	386.0	COG1073@1|root,COG1926@1|root,COG1073@2|Bacteria,COG1926@2|Bacteria,2GJUU@201174|Actinobacteria,4EGKY@85012|Streptosporangiales	201174|Actinobacteria	S	Phosphoribosyl transferase domain	-	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K07100	-	-	-	-	ko00000	-	-	-	DLH,Pribosyltran
SHD1_k127_4082929_0	1210884.HG799463_gene9574	3.475e-315	988.0	COG0474@1|root,COG0474@2|Bacteria,2IYQI@203682|Planctomycetes	203682|Planctomycetes	P	Cation transporter/ATPase, N-terminus	-	-	3.6.3.2	ko:K01531	-	-	-	-	ko00000,ko01000	3.A.3.4	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
SHD1_k127_4082929_3	1382356.JQMP01000003_gene1584	1.556e-57	207.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,2G5QB@200795|Chloroflexi,27XKK@189775|Thermomicrobia	189775|Thermomicrobia	C	Succinyl-CoA ligase like flavodoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
SHD1_k127_4085512_0	1242864.D187_002075	2.434e-109	363.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,42MKR@68525|delta/epsilon subdivisions,2WIS3@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	PFAM Aminotransferase class I and II	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
SHD1_k127_4085512_1	1379270.AUXF01000005_gene330	3.194e-80	270.0	COG0183@1|root,COG0183@2|Bacteria,1ZT7B@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Thiolase, C-terminal domain	-	-	2.3.1.174,2.3.1.223	ko:K02615	ko00360,ko01120,map00360,map01120	-	R00829,R09839	RC00004,RC00326,RC03003	ko00000,ko00001,ko01000	-	-	-	Thiolase_C,Thiolase_N
SHD1_k127_4089759_1	1144275.COCOR_03426	1.217e-05	53.0	COG0222@1|root,COG0222@2|Bacteria	2|Bacteria	J	mitochondrial gene expression	rplL	-	-	ko:K02935	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L12,Ribosomal_L12_N
SHD1_k127_4089759_0	485913.Krac_4830	3.798e-52	205.0	COG3391@1|root,COG3391@2|Bacteria,2G849@200795|Chloroflexi	200795|Chloroflexi	M	Phosphoesterase family	-	-	-	-	-	-	-	-	-	-	-	-	Phosphoesterase
SHD1_k127_4115228_2	290397.Adeh_2856	3.158e-29	126.0	COG0558@1|root,COG0558@2|Bacteria,1N9TT@1224|Proteobacteria,42V2Q@68525|delta/epsilon subdivisions,2WRYY@28221|Deltaproteobacteria,2YWYE@29|Myxococcales	28221|Deltaproteobacteria	I	GtrA-like protein	-	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf,GtrA
SHD1_k127_4115228_3	322710.Avin_44370	6.271e-25	117.0	COG1597@1|root,COG1597@2|Bacteria,1RB97@1224|Proteobacteria,1S4B3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	lipid kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	Mmp37
SHD1_k127_4115228_4	290397.Adeh_2078	5.393e-09	67.0	COG0204@1|root,COG0204@2|Bacteria,1MY51@1224|Proteobacteria,42QIX@68525|delta/epsilon subdivisions,2WJHE@28221|Deltaproteobacteria,2YZDA@29|Myxococcales	28221|Deltaproteobacteria	I	Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
SHD1_k127_4115228_0	632518.Calow_1893	5.969e-90	312.0	COG0156@1|root,COG0156@2|Bacteria,1TPUX@1239|Firmicutes,2491D@186801|Clostridia,42FUG@68295|Thermoanaerobacterales	186801|Clostridia	H	PFAM Aminotransferase class I and II	kbl	GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008710,GO:0008890,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.3.1.29,2.3.1.47,6.2.1.14	ko:K00639,ko:K00652,ko:K01906	ko00260,ko00780,ko01100,map00260,map00780,map01100	M00123,M00573,M00577	R00371,R03209,R03210,R10124	RC00004,RC00014,RC00039,RC00394,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
SHD1_k127_4115228_1	1379270.AUXF01000001_gene2768	2.594e-51	196.0	COG1597@1|root,COG1597@2|Bacteria,1ZU66@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Diacylglycerol kinase catalytic domain (presumed)	-	-	2.7.1.107	ko:K07029	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	-	R02240	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	DAGK_cat
SHD1_k127_4121329_3	1379270.AUXF01000004_gene3144	2.403e-08	55.0	COG0143@1|root,COG0143@2|Bacteria,1ZTDB@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	tRNA synthetases class I (M)	-	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1g
SHD1_k127_4121329_2	865938.Weevi_1329	4.609e-38	154.0	COG0739@1|root,COG0739@2|Bacteria,4NGHH@976|Bacteroidetes,1HX46@117743|Flavobacteriia	976|Bacteroidetes	M	Peptidase, M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
SHD1_k127_4121329_1	861299.J421_2651	2.382e-64	238.0	COG0521@1|root,COG0521@2|Bacteria	2|Bacteria	H	Mo-molybdopterin cofactor metabolic process	-	-	-	ko:K21572	-	-	-	-	ko00000,ko02000	8.A.46.1,8.A.46.3	-	-	SusD-like,SusD-like_2,SusD_RagB
SHD1_k127_4121329_0	861299.J421_2650	8.734e-188	610.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,Plug,TonB_dep_Rec
SHD1_k127_4128862_4	861299.J421_6070	1.661e-73	255.0	COG1682@1|root,COG1682@2|Bacteria	2|Bacteria	GM	macromolecule localization	-	-	-	ko:K01992,ko:K09690	ko02010,map02010	M00250,M00254	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.103	-	-	ABC2_membrane
SHD1_k127_4128862_2	861299.J421_6071	7.847e-99	336.0	COG1134@1|root,COG1134@2|Bacteria	2|Bacteria	GM	teichoic acid transport	-	-	3.6.3.38	ko:K01990,ko:K09689,ko:K09691	ko02010,map02010	M00249,M00250,M00254	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.101,3.A.1.103	-	-	ABC_tran,Wzt_C
SHD1_k127_4128862_3	1158756.AQXQ01000011_gene718	4.293e-94	332.0	COG0394@1|root,COG3919@1|root,COG0394@2|Bacteria,COG3919@2|Bacteria,1R94Z@1224|Proteobacteria,1RQ74@1236|Gammaproteobacteria,1WZV0@135613|Chromatiales	135613|Chromatiales	T	ATP-grasp domain	-	-	-	-	-	-	-	-	-	-	-	-	LMWPc
SHD1_k127_4128862_0	29581.BW37_04051	2.511e-139	453.0	COG1657@1|root,COG1657@2|Bacteria,1N9TZ@1224|Proteobacteria,2VX9G@28216|Betaproteobacteria	28216|Betaproteobacteria	I	PFAM Prenyltransferase squalene oxidase	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_4128862_1	1173024.KI912149_gene6263	2.064e-103	347.0	COG0454@1|root,COG1846@1|root,COG0456@2|Bacteria,COG1846@2|Bacteria,1GKR9@1117|Cyanobacteria,1JMKR@1189|Stigonemataceae	1117|Cyanobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
SHD1_k127_4128862_7	861299.J421_3243	1.749e-06	55.0	COG2976@1|root,COG2976@2|Bacteria,1ZTZV@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Tetratricopeptide repeat-like domain	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
SHD1_k127_4131958_8	1379270.AUXF01000003_gene3675	2.762e-16	79.0	2CFMP@1|root,2ZEHG@2|Bacteria,1ZU7I@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_4131958_4	1267534.KB906754_gene3348	3.617e-112	370.0	COG0300@1|root,COG0300@2|Bacteria,3Y4AK@57723|Acidobacteria	57723|Acidobacteria	S	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
SHD1_k127_4131958_2	861299.J421_3775	3.257e-172	552.0	COG1078@1|root,COG1078@2|Bacteria,1ZT3F@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K06885	-	-	-	-	ko00000	-	-	-	HD
SHD1_k127_4131958_1	861299.J421_3772	2.843e-261	815.0	COG1866@1|root,COG1866@2|Bacteria,1ZSTT@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA	pckA	-	4.1.1.49	ko:K01610	ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00170	R00341	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_ATP
SHD1_k127_4131958_0	861299.J421_3771	0.0	1117.0	COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1ZT01@142182|Gemmatimonadetes	2|Bacteria	C	Phosphate acetyl/butaryl transferase	maeB	GO:0003674,GO:0003824,GO:0004470,GO:0004473,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0030145,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0055114	1.1.1.38,1.1.1.40,2.3.1.8	ko:K00027,ko:K00029,ko:K00625,ko:K13788	ko00430,ko00620,ko00640,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,ko02020,map00430,map00620,map00640,map00680,map00710,map00720,map01100,map01120,map01200,map02020	M00169,M00172,M00357,M00579	R00214,R00216,R00230,R00921	RC00004,RC00105,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1637	Malic_M,PTA_PTB,malic
SHD1_k127_4131958_6	379066.GAU_2835	3.207e-44	168.0	COG0671@1|root,COG0671@2|Bacteria,1ZUGJ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Acid phosphatase homologues	-	-	-	-	-	-	-	-	-	-	-	-	PAP2
SHD1_k127_4131958_3	861299.J421_3762	4.257e-115	387.0	COG0648@1|root,COG0648@2|Bacteria,1ZSY0@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin	nfo	-	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
SHD1_k127_4131958_5	861299.J421_3761	6.576e-109	370.0	COG4942@1|root,COG4942@2|Bacteria,1ZSU6@142182|Gemmatimonadetes	142182|Gemmatimonadetes	D	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
SHD1_k127_4131958_7	861299.J421_3760	6.671e-37	142.0	COG2177@1|root,COG2177@2|Bacteria,1ZTDR@142182|Gemmatimonadetes	142182|Gemmatimonadetes	D	Part of the ABC transporter FtsEX involved in	-	-	-	ko:K09811	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	-
SHD1_k127_4155108_9	861299.J421_2659	1.604e-19	92.0	COG0612@1|root,COG0612@2|Bacteria,1ZT1M@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Insulinase (Peptidase family M16)	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
SHD1_k127_4155108_1	379066.GAU_2794	4.417e-125	426.0	COG1305@1|root,COG1305@2|Bacteria	2|Bacteria	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DUF3857,Transglut_core
SHD1_k127_4155108_6	1356852.N008_19240	4.377e-48	180.0	COG0400@1|root,COG0400@2|Bacteria,4NHWT@976|Bacteroidetes,47QUH@768503|Cytophagia	976|Bacteroidetes	S	PFAM phospholipase Carboxylesterase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_2,FSH1
SHD1_k127_4155108_5	760192.Halhy_1966	1.412e-56	214.0	COG1215@1|root,COG1215@2|Bacteria,4NFI8@976|Bacteroidetes,1ISNS@117747|Sphingobacteriia	976|Bacteroidetes	M	Pfam:DUF2029	-	-	-	-	-	-	-	-	-	-	-	-	GT87
SHD1_k127_4155108_8	1198114.AciX9_1467	1.607e-33	140.0	COG3394@1|root,COG3394@2|Bacteria,3Y441@57723|Acidobacteria,2JI4E@204432|Acidobacteriia	204432|Acidobacteriia	G	YdjC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YdjC
SHD1_k127_4155108_7	269799.Gmet_0242	7.67e-45	173.0	COG1215@1|root,COG1215@2|Bacteria,1RJNP@1224|Proteobacteria,42ST7@68525|delta/epsilon subdivisions,2X7KP@28221|Deltaproteobacteria,43V18@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
SHD1_k127_4155108_4	1242864.D187_000942	8.396e-79	284.0	COG2220@1|root,COG2220@2|Bacteria,1MV20@1224|Proteobacteria,42QY0@68525|delta/epsilon subdivisions,2WMTP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
SHD1_k127_4155108_3	1382306.JNIM01000001_gene3772	4.658e-101	341.0	COG0604@1|root,COG0604@2|Bacteria,2G7Z0@200795|Chloroflexi	200795|Chloroflexi	C	PFAM Alcohol dehydrogenase zinc-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
SHD1_k127_4155108_0	861299.J421_2044	2.551e-155	519.0	2EXVN@1|root,33R4S@2|Bacteria,1ZTD4@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_4155108_2	215803.DB30_5797	1.402e-107	364.0	COG3667@1|root,COG3667@2|Bacteria,1R6TA@1224|Proteobacteria,438ST@68525|delta/epsilon subdivisions,2X9CS@28221|Deltaproteobacteria,2YXPE@29|Myxococcales	28221|Deltaproteobacteria	P	copper resistance	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_4168557_2	1183438.GKIL_2082	1.594e-28	116.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1GDGA@1117|Cyanobacteria	1117|Cyanobacteria	EU	Prolyl oligopeptidase family	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
SHD1_k127_4168557_1	861299.J421_4391	1.528e-78	272.0	COG1376@1|root,COG1376@2|Bacteria,1ZUZG@142182|Gemmatimonadetes	2|Bacteria	S	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	LysM,PG_binding_1,YkuD
SHD1_k127_4168557_0	886293.Sinac_4898	9.07e-237	742.0	COG1233@1|root,COG1233@2|Bacteria,2IX17@203682|Planctomycetes	203682|Planctomycetes	Q	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
SHD1_k127_4181027_5	1345697.M493_06655	3.44e-19	101.0	COG0840@1|root,COG5278@1|root,COG0840@2|Bacteria,COG5278@2|Bacteria,1TP5A@1239|Firmicutes,4H9RZ@91061|Bacilli,1WG5M@129337|Geobacillus	91061|Bacilli	NT	PFAM Chemotaxis methyl-accepting receptor, signalling	tlpA1	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,CHASE3,HAMP,MCPsignal
SHD1_k127_4181027_0	378806.STAUR_5297	4.617e-139	452.0	COG3191@1|root,COG3191@2|Bacteria,1MWDP@1224|Proteobacteria,42YGK@68525|delta/epsilon subdivisions,2WU4M@28221|Deltaproteobacteria,2YWRP@29|Myxococcales	28221|Deltaproteobacteria	EQ	Peptidase family S58	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S58
SHD1_k127_4181027_2	379066.GAU_0192	2.205e-79	284.0	COG0075@1|root,COG0075@2|Bacteria,1ZTF3@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
SHD1_k127_4181027_3	1408473.JHXO01000005_gene1511	2.342e-34	141.0	COG1335@1|root,COG1335@2|Bacteria	2|Bacteria	Q	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	-	-	3.5.1.19	ko:K08281	ko00760,ko01100,map00760,map01100	-	R01268	RC00100	ko00000,ko00001,ko01000	-	-	-	Isochorismatase,MerR_1
SHD1_k127_4181027_4	312153.Pnuc_0492	8.046e-20	101.0	COG2885@1|root,COG2885@2|Bacteria,1N6EM@1224|Proteobacteria,2VM27@28216|Betaproteobacteria,1JZN0@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Belongs to the ompA family	ompA	-	-	ko:K03286	-	-	-	-	ko00000,ko02000	1.B.6	-	-	OmpA
SHD1_k127_4181027_6	1379270.AUXF01000007_gene927	4.884e-08	64.0	COG0392@1|root,COG0392@2|Bacteria,1ZSUQ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
SHD1_k127_4181027_1	469383.Cwoe_5866	1.437e-130	432.0	COG1488@1|root,COG1488@2|Bacteria,2GJAT@201174|Actinobacteria,4CQTG@84995|Rubrobacteria	84995|Rubrobacteria	H	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP	-	-	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	-	Isochorismatase,QRPTase_C,QRPTase_N
SHD1_k127_4184454_2	869213.JCM21142_96	2.987e-65	237.0	COG2235@1|root,COG2235@2|Bacteria,4NHKZ@976|Bacteroidetes,47JM7@768503|Cytophagia	976|Bacteroidetes	E	Arginine deiminase	-	-	3.5.3.6	ko:K01478	ko00220,ko01100,ko01110,ko01130,map00220,map01100,map01110,map01130	-	R00552	RC00177	ko00000,ko00001,ko01000	-	-	-	Amidinotransf
SHD1_k127_4184454_1	861299.J421_3450	1.562e-78	276.0	COG0847@1|root,COG0847@2|Bacteria,1ZTNH@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	EXOIII	-	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
SHD1_k127_4184454_0	861299.J421_3449	8.608e-79	267.0	COG0491@1|root,COG0491@2|Bacteria,1ZT7V@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
SHD1_k127_4193769_2	861299.J421_3744	6.473e-98	325.0	COG1995@1|root,COG1995@2|Bacteria,1ZT2S@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Pyridoxal phosphate biosynthetic protein PdxA	-	-	1.1.1.262	ko:K00097	ko00750,ko01100,map00750,map01100	M00124	R05681,R05837,R07406	RC00089,RC00675,RC01475	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxA
SHD1_k127_4193769_3	1489678.RDMS_12985	8.324e-79	276.0	COG1230@1|root,COG1230@2|Bacteria	2|Bacteria	P	cation diffusion facilitator family transporter	zitB	GO:0000041,GO:0003674,GO:0005215,GO:0005385,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006829,GO:0008150,GO:0008324,GO:0015075,GO:0015318,GO:0016020,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0044464,GO:0046873,GO:0046915,GO:0051179,GO:0051234,GO:0055085,GO:0070838,GO:0071577,GO:0071944,GO:0072509,GO:0072511,GO:0098655,GO:0098660,GO:0098662	-	ko:K16264	-	-	-	-	ko00000,ko02000	2.A.4.1	-	iNRG857_1313.NRG857_03325,iPC815.YPO1129	Cation_efflux,ZT_dimer
SHD1_k127_4193769_1	861299.J421_3743	2.472e-173	559.0	COG2805@1|root,COG2805@2|Bacteria,1ZSTM@142182|Gemmatimonadetes	142182|Gemmatimonadetes	NU	Type II/IV secretion system protein	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
SHD1_k127_4193769_0	1379270.AUXF01000003_gene3703	5.428e-307	950.0	COG1217@1|root,COG1217@2|Bacteria,1ZT8A@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	Elongation factor G C-terminus	-	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
SHD1_k127_4193769_4	1123405.AUMM01000031_gene1488	1.389e-07	53.0	2DTS4@1|root,33MFD@2|Bacteria,1VKHK@1239|Firmicutes,4I120@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_421001_2	861299.J421_2606	2.138e-68	238.0	COG2094@1|root,COG2094@2|Bacteria,1ZTNT@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	Methylpurine-DNA glycosylase (MPG)	-	-	3.2.2.21	ko:K03652	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Pur_DNA_glyco
SHD1_k127_421001_1	234267.Acid_1640	9.799e-187	612.0	COG2866@1|root,COG2866@2|Bacteria,3Y3X8@57723|Acidobacteria	57723|Acidobacteria	E	Peptidase M14, carboxypeptidase A	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
SHD1_k127_421001_0	861299.J421_2609	7.17e-193	607.0	COG0156@1|root,COG0156@2|Bacteria,1ZST6@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Beta-eliminating lyase	-	-	2.3.1.29	ko:K00639	ko00260,map00260	-	R00371	RC00004,RC00394	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
SHD1_k127_4215228_3	379066.GAU_1625	4.671e-62	219.0	COG1212@1|root,COG1212@2|Bacteria,1ZSRD@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria	kdsB	-	2.7.7.38	ko:K00979	ko00540,ko01100,map00540,map01100	M00063	R03351,R11396	RC00152,RC00910	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_3
SHD1_k127_4215228_1	861299.J421_3261	3.758e-93	308.0	COG0512@1|root,COG0512@2|Bacteria,1ZTK8@142182|Gemmatimonadetes	142182|Gemmatimonadetes	EH	Peptidase C26	-	-	4.1.3.27	ko:K01658	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
SHD1_k127_4215228_0	861299.J421_3262	6.657e-122	394.0	COG4974@1|root,COG4974@2|Bacteria,1ZTAH@142182|Gemmatimonadetes	142182|Gemmatimonadetes	D	Phage integrase, N-terminal SAM-like domain	xerD	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
SHD1_k127_4229187_7	861299.J421_1159	6.283e-24	106.0	COG1585@1|root,COG1585@2|Bacteria,1ZTYB@142182|Gemmatimonadetes	142182|Gemmatimonadetes	OU	Membrane protein implicated in regulation of membrane protease activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_4229187_8	861299.J421_1160	5.913e-23	104.0	28WNH@1|root,2ZIN9@2|Bacteria,1ZV8H@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_4229187_6	861299.J421_1161	4.244e-29	119.0	2FICF@1|root,34A4P@2|Bacteria,1ZTX7@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_4229187_2	861299.J421_1163	2.115e-112	366.0	COG0445@1|root,COG0445@2|Bacteria,1ZT9H@142182|Gemmatimonadetes	142182|Gemmatimonadetes	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	-	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
SHD1_k127_4229187_0	1379270.AUXF01000002_gene1223	4.608e-160	513.0	COG0445@1|root,COG0445@2|Bacteria,1ZT9H@142182|Gemmatimonadetes	142182|Gemmatimonadetes	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	-	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
SHD1_k127_4229187_5	861299.J421_1164	2.408e-47	180.0	COG2968@1|root,COG2968@2|Bacteria,1ZTTR@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Protein of unknown function (DUF541)	-	-	-	ko:K09807	-	-	-	-	ko00000	-	-	-	SIMPL
SHD1_k127_4229187_1	861299.J421_1165	1.478e-117	387.0	COG1192@1|root,COG1192@2|Bacteria,1ZTH2@142182|Gemmatimonadetes	142182|Gemmatimonadetes	D	Cellulose biosynthesis protein BcsQ	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
SHD1_k127_4229187_3	861299.J421_1167	3.654e-108	358.0	COG1475@1|root,COG1475@2|Bacteria,1ZSKT@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	ParB-like nuclease domain	-	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
SHD1_k127_4229187_9	390989.JOEG01000025_gene66	3.799e-14	82.0	COG4942@1|root,COG4942@2|Bacteria,2I63X@201174|Actinobacteria,4DMSH@85008|Micromonosporales	201174|Actinobacteria	D	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
SHD1_k127_4229187_10	1046627.BZARG_1660	2.791e-12	74.0	COG1664@1|root,COG1664@2|Bacteria,4NUZA@976|Bacteroidetes,1I47M@117743|Flavobacteriia	976|Bacteroidetes	M	Integral membrane protein CcmA involved in cell shape determination	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
SHD1_k127_4229187_4	861299.J421_1169	2.885e-86	293.0	COG0327@1|root,COG0327@2|Bacteria,1ZTE0@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	NIF3 (NGG1p interacting factor 3)	-	-	-	-	-	-	-	-	-	-	-	-	NIF3
SHD1_k127_4229187_11	1121106.JQKB01000034_gene5998	2.191e-11	70.0	COG1408@1|root,COG1408@2|Bacteria,1MUH5@1224|Proteobacteria,2TVHN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	metallophosphoesterase	-	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos,Metallophos_2
SHD1_k127_4231050_2	861299.J421_3341	2.015e-20	94.0	COG0514@1|root,COG0514@2|Bacteria,1ZSNS@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	RecQ zinc-binding	-	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecQ_Zn_bind
SHD1_k127_4231050_0	379066.GAU_1701	2.216e-188	595.0	COG1960@1|root,COG1960@2|Bacteria,1ZSVZ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	ko:K18244	-	-	-	-	ko00000,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
SHD1_k127_4231050_1	880073.Calab_2283	1.126e-110	374.0	COG1530@1|root,COG1530@2|Bacteria,2NNQR@2323|unclassified Bacteria	2|Bacteria	J	Ribonuclease E/G family	rng	-	3.1.26.12	ko:K08300,ko:K08301	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
SHD1_k127_4250118_4	861299.J421_4205	2.915e-59	217.0	2EY14@1|root,33RA2@2|Bacteria,1ZSR5@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_4250118_0	861299.J421_4207	1.353e-320	1005.0	COG0612@1|root,COG0612@2|Bacteria,1ZSU0@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Insulinase (Peptidase family M16)	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
SHD1_k127_4250118_2	861299.J421_4211	2.502e-150	484.0	COG0457@1|root,COG0457@2|Bacteria,1ZSYB@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2
SHD1_k127_4250118_3	1379270.AUXF01000001_gene2782	5.451e-93	315.0	COG2313@1|root,COG2313@2|Bacteria,1ZTNI@142182|Gemmatimonadetes	142182|Gemmatimonadetes	Q	Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway	psuG	-	4.2.1.70	ko:K16329	ko00240,map00240	-	R01055	RC00432,RC00433	ko00000,ko00001,ko01000	-	-	-	Indigoidine_A
SHD1_k127_4250118_1	1183438.GKIL_0436	6.816e-175	566.0	COG2234@1|root,COG2234@2|Bacteria	2|Bacteria	DZ	aminopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
SHD1_k127_4255598_2	1379270.AUXF01000005_gene571	5.515e-16	83.0	2FFNT@1|root,347K5@2|Bacteria,1ZTY9@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_4255598_1	794903.OPIT5_28965	1.066e-27	116.0	COG3682@1|root,COG3682@2|Bacteria,46SZH@74201|Verrucomicrobia	74201|Verrucomicrobia	K	Penicillinase repressor	-	-	-	-	-	-	-	-	-	-	-	-	Penicillinase_R
SHD1_k127_4255598_0	861299.J421_1461	1.4e-104	364.0	COG4219@1|root,COG4219@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,HEAT_2,Peptidase_M56,Secretin,TonB_C
SHD1_k127_4281551_2	861299.J421_3663	2.651e-129	417.0	COG1228@1|root,COG1228@2|Bacteria,1ZSU7@142182|Gemmatimonadetes	142182|Gemmatimonadetes	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
SHD1_k127_4281551_1	379066.GAU_3015	2.184e-132	433.0	COG1680@1|root,COG1680@2|Bacteria,1ZTCC@142182|Gemmatimonadetes	142182|Gemmatimonadetes	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
SHD1_k127_4281551_0	861299.J421_0464	2.673e-181	582.0	COG0793@1|root,COG0793@2|Bacteria,1ZT92@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	tail specific protease	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_S41
SHD1_k127_4281551_3	861299.J421_1591	6.157e-77	265.0	COG0498@1|root,COG0498@2|Bacteria,1ZSVV@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
SHD1_k127_4282249_2	861299.J421_1587	1.93e-115	385.0	COG0642@1|root,COG2205@2|Bacteria,1ZUG2@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	Domain of unknown function (DUF4118)	-	-	2.7.13.3	ko:K07646	ko02020,map02020	M00454	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF4118,HATPase_c,HisKA
SHD1_k127_4282249_5	861299.J421_3696	6.163e-29	117.0	COG0361@1|root,COG0361@2|Bacteria,1ZV5Y@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	-	-	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
SHD1_k127_4282249_6	861299.J421_1913	1.132e-08	58.0	COG0828@1|root,COG0828@2|Bacteria,1ZU81@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Ribosomal protein S21	-	-	-	ko:K02970	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S21
SHD1_k127_4282249_1	937777.Deipe_2643	5.8e-183	584.0	COG0513@1|root,COG0513@2|Bacteria,1WKZ3@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	L	helicase superfamily c-terminal domain	-	-	3.6.4.13	ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DEAD,Helicase_C
SHD1_k127_4282249_0	861299.J421_2504	4.807e-223	697.0	COG0372@1|root,COG0372@2|Bacteria,1ZT4W@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Citrate synthase, C-terminal domain	-	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
SHD1_k127_4282249_3	1379698.RBG1_1C00001G0798	3.412e-95	352.0	COG0308@1|root,COG1413@1|root,COG0308@2|Bacteria,COG1413@2|Bacteria,2NPGQ@2323|unclassified Bacteria	2|Bacteria	E	aminopeptidase	pepN	-	3.4.11.2	ko:K01256	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	HEAT_2,Peptidase_M1
SHD1_k127_4282249_4	861299.J421_5977	3.548e-36	140.0	COG0665@1|root,COG0665@2|Bacteria,1ZUQF@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
SHD1_k127_4287401_0	861299.J421_3522	6.451e-215	679.0	COG0013@1|root,COG0013@2|Bacteria,1ZT18@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
SHD1_k127_4287401_1	504472.Slin_5644	2.471e-35	145.0	COG1646@1|root,COG1646@2|Bacteria,4NER8@976|Bacteroidetes,47MXM@768503|Cytophagia	976|Bacteroidetes	I	Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P)	pcrB	-	-	ko:K07094	-	-	-	-	ko00000,ko01000	-	-	-	PcrB
SHD1_k127_4299089_1	1449049.JONW01000011_gene2279	1.045e-37	157.0	COG1520@1|root,COG1520@2|Bacteria	2|Bacteria	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,PQQ_3
SHD1_k127_4299089_0	861299.J421_0531	2.308e-56	205.0	COG0160@1|root,COG0739@1|root,COG2334@1|root,COG0160@2|Bacteria,COG0739@2|Bacteria,COG2334@2|Bacteria	2|Bacteria	S	homoserine kinase activity	gabT	-	2.6.1.19,2.6.1.22	ko:K00823,ko:K07250	ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648,R04188	RC00006,RC00062,RC00160	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	APH,Aminotran_3,Peptidase_M23
SHD1_k127_4350028_3	247639.MGP2080_14054	3.807e-21	99.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	yesJ	-	3.1.3.48	ko:K01104	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_10,Y_phosphatase3
SHD1_k127_4350028_0	1121920.AUAU01000009_gene1955	1.271e-187	593.0	COG1858@1|root,COG1858@2|Bacteria,3Y7B8@57723|Acidobacteria	57723|Acidobacteria	P	cytochrome C peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_4350028_1	1382356.JQMP01000004_gene545	8.216e-118	386.0	COG3958@1|root,COG3958@2|Bacteria,2G8E1@200795|Chloroflexi,27XY5@189775|Thermomicrobia	189775|Thermomicrobia	G	Transketolase, pyrimidine binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
SHD1_k127_4350028_2	644966.Tmar_1967	6.737e-105	348.0	COG3959@1|root,COG3959@2|Bacteria,1TT51@1239|Firmicutes,247IK@186801|Clostridia,3WCW3@538999|Clostridiales incertae sedis	186801|Clostridia	G	Transketolase, thiamine diphosphate binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
SHD1_k127_4359188_8	861299.J421_1280	5.61e-123	419.0	COG0515@1|root,COG3629@1|root,COG0515@2|Bacteria,COG3629@2|Bacteria,1ZTSR@142182|Gemmatimonadetes	2|Bacteria	T	Bacterial transcriptional activator domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	AAA_16,BTAD,TPR_12,Trans_reg_C
SHD1_k127_4359188_9	448385.sce2438	1.555e-98	349.0	COG1294@1|root,COG1294@2|Bacteria,1MURP@1224|Proteobacteria,42UHT@68525|delta/epsilon subdivisions,2WR0M@28221|Deltaproteobacteria,2YUP9@29|Myxococcales	28221|Deltaproteobacteria	C	oxidase, subunit	cydB	-	1.10.3.14	ko:K00426	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_II
SHD1_k127_4359188_1	290397.Adeh_0939	1.223e-165	535.0	COG1271@1|root,COG1271@2|Bacteria,1MV60@1224|Proteobacteria,42MB8@68525|delta/epsilon subdivisions,2WIW7@28221|Deltaproteobacteria,2YU2P@29|Myxococcales	28221|Deltaproteobacteria	C	ubiquinol oxidase subunit I	cydA	-	1.10.3.14	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_I
SHD1_k127_4359188_3	861299.J421_2318	1.311e-160	513.0	COG1744@1|root,COG1744@2|Bacteria,1ZTAF@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	ABC transporter substrate-binding protein PnrA-like	-	-	-	ko:K07335	-	-	-	-	ko00000	-	-	-	Bmp
SHD1_k127_4359188_0	1379270.AUXF01000002_gene1764	1.637e-183	588.0	COG3845@1|root,COG3845@2|Bacteria,1ZSUG@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	ABC transporter	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
SHD1_k127_4359188_5	861299.J421_2316	1.052e-136	444.0	COG4603@1|root,COG4603@2|Bacteria,1ZTDA@142182|Gemmatimonadetes	142182|Gemmatimonadetes	U	Branched-chain amino acid transport system / permease component	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
SHD1_k127_4359188_7	861299.J421_2315	7.556e-125	409.0	COG1079@1|root,COG1079@2|Bacteria,1ZTFZ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	U	Branched-chain amino acid transport system / permease component	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
SHD1_k127_4359188_6	379066.GAU_0426	1.145e-126	418.0	COG0477@1|root,COG2814@2|Bacteria,1ZT84@142182|Gemmatimonadetes	142182|Gemmatimonadetes	EGP	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
SHD1_k127_4359188_4	575540.Isop_3122	2.071e-145	474.0	COG0463@1|root,COG0463@2|Bacteria,2J2HF@203682|Planctomycetes	203682|Planctomycetes	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
SHD1_k127_4359188_10	1403819.BATR01000092_gene2705	1.005e-52	209.0	COG0500@1|root,COG2226@2|Bacteria,46XQZ@74201|Verrucomicrobia,2IWE6@203494|Verrucomicrobiae	203494|Verrucomicrobiae	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
SHD1_k127_4359188_12	344747.PM8797T_24031	2.741e-12	80.0	28P7U@1|root,2ZC21@2|Bacteria,2J309@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_4359188_2	861299.J421_0062	2.994e-163	532.0	COG1252@1|root,COG1252@2|Bacteria,1ZT8C@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
SHD1_k127_4359188_11	997346.HMPREF9374_2151	2.391e-35	139.0	COG1178@1|root,COG1178@2|Bacteria,1TPMX@1239|Firmicutes,4HA2U@91061|Bacilli,27CKY@186824|Thermoactinomycetaceae	91061|Bacilli	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
SHD1_k127_4383496_2	522306.CAP2UW1_2883	2.014e-63	230.0	COG1262@1|root,COG4249@1|root,COG1262@2|Bacteria,COG4249@2|Bacteria,1NQ5K@1224|Proteobacteria,2VPHG@28216|Betaproteobacteria	28216|Betaproteobacteria	KLT	peptidase C14 caspase catalytic subunit p20	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,Peptidase_C14
SHD1_k127_4383496_0	671143.DAMO_0095	3.779e-163	525.0	COG1282@1|root,COG1282@2|Bacteria,2NQMF@2323|unclassified Bacteria	2|Bacteria	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	pntB	-	1.6.1.2	ko:K00325	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB
SHD1_k127_4383496_3	290397.Adeh_3006	2.806e-34	135.0	COG3288@1|root,COG3288@2|Bacteria,1MZ3E@1224|Proteobacteria,42VRD@68525|delta/epsilon subdivisions,2WSCM@28221|Deltaproteobacteria,2Z2UB@29|Myxococcales	28221|Deltaproteobacteria	C	4TM region of pyridine nucleotide transhydrogenase, mitoch	-	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB_4TM
SHD1_k127_4383496_1	861299.J421_0516	1.7e-129	423.0	COG3288@1|root,COG3288@2|Bacteria,1ZUJQ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Alanine dehydrogenase/PNT, N-terminal domain	-	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
SHD1_k127_4397601_7	118166.JH976538_gene5166	5.396e-08	57.0	COG0431@1|root,COG0431@2|Bacteria,1G81A@1117|Cyanobacteria	1117|Cyanobacteria	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
SHD1_k127_4397601_5	760117.JN27_16865	7.854e-47	175.0	COG3797@1|root,COG3797@2|Bacteria,1N0SN@1224|Proteobacteria,2VVYM@28216|Betaproteobacteria,4756W@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF1697)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1697
SHD1_k127_4397601_4	682795.AciX8_0006	1.091e-59	214.0	COG4291@1|root,COG4291@2|Bacteria,3Y4RY@57723|Acidobacteria,2JKW1@204432|Acidobacteriia	204432|Acidobacteriia	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_4397601_0	518766.Rmar_2690	4.467e-174	558.0	COG0304@1|root,COG0304@2|Bacteria,4NEKC@976|Bacteroidetes,1FIY5@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
SHD1_k127_4397601_2	1379270.AUXF01000002_gene1132	1.795e-92	317.0	COG0010@1|root,COG0010@2|Bacteria	2|Bacteria	E	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines	-	-	-	-	-	-	-	-	-	-	-	-	Arginase
SHD1_k127_4397601_6	404589.Anae109_0423	2.003e-42	161.0	COG2062@1|root,COG2062@2|Bacteria,1PKQQ@1224|Proteobacteria,43AAX@68525|delta/epsilon subdivisions,2WYNV@28221|Deltaproteobacteria,2Z26S@29|Myxococcales	28221|Deltaproteobacteria	T	Phosphoglycerate mutase family	-	-	-	ko:K08296	-	-	-	-	ko00000,ko01000	-	-	-	His_Phos_1
SHD1_k127_4397601_1	861299.J421_6004	1.813e-105	348.0	COG3279@1|root,COG3279@2|Bacteria,1ZUUN@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	LytTr DNA-binding domain	-	-	-	ko:K02477	-	-	-	-	ko00000,ko02022	-	-	-	LytTR,Response_reg
SHD1_k127_4397601_3	861299.J421_6005	1.026e-89	308.0	COG2972@1|root,COG2972@2|Bacteria,1ZURN@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	His_kinase
SHD1_k127_4397601_8	1121946.AUAX01000016_gene4731	0.0001393	52.0	2D579@1|root,32TID@2|Bacteria,2IMWE@201174|Actinobacteria,4DFF2@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_4419863_0	864702.OsccyDRAFT_4212	4.371e-258	813.0	COG0403@1|root,COG1003@1|root,COG0403@2|Bacteria,COG1003@2|Bacteria,1G1HW@1117|Cyanobacteria,1H6Y0@1150|Oscillatoriales	1117|Cyanobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvP	-	1.4.4.2	ko:K00281	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	GDC-P
SHD1_k127_4419863_2	1227453.C444_06246	7.865e-38	149.0	COG0509@1|root,arCOG01303@2157|Archaea,2XY1B@28890|Euryarchaeota,23W1R@183963|Halobacteria	183963|Halobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
SHD1_k127_4419863_1	590998.Celf_3727	1.618e-117	387.0	COG0404@1|root,COG0404@2|Bacteria,2GJ47@201174|Actinobacteria,4F0J6@85016|Cellulomonadaceae	201174|Actinobacteria	E	The glycine cleavage system catalyzes the degradation of glycine	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
SHD1_k127_4423660_0	240015.ACP_3514	7.142e-181	585.0	COG0577@1|root,COG0577@2|Bacteria,3Y6R1@57723|Acidobacteria,2JMKX@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
SHD1_k127_4423660_1	203275.BFO_0330	2.46e-13	79.0	COG1215@1|root,COG1215@2|Bacteria,4NFI8@976|Bacteroidetes,2FQAZ@200643|Bacteroidia,22W2Z@171551|Porphyromonadaceae	976|Bacteroidetes	M	Psort location CytoplasmicMembrane, score 10.00	-	-	-	-	-	-	-	-	-	-	-	-	GT87
SHD1_k127_4429992_2	1379270.AUXF01000006_gene62	2.331e-124	403.0	COG0484@1|root,COG0484@2|Bacteria,1ZSVD@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	-	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
SHD1_k127_4429992_5	379066.GAU_1897	1.848e-67	239.0	COG2264@1|root,COG2264@2|Bacteria,1ZST2@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Met-10+ like-protein	prmA	-	-	ko:K02687	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PrmA
SHD1_k127_4429992_4	861299.J421_3466	2.941e-72	251.0	COG1385@1|root,COG1385@2|Bacteria,1ZTJ2@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	-	-	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
SHD1_k127_4429992_7	861299.J421_3465	3.71e-39	153.0	COG0537@1|root,COG0537@2|Bacteria,1ZU0K@142182|Gemmatimonadetes	142182|Gemmatimonadetes	FG	HIT domain	-	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
SHD1_k127_4429992_6	861299.J421_3464	2.482e-45	168.0	COG1610@1|root,COG1610@2|Bacteria,1ZTS3@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Yqey-like protein	-	-	-	ko:K09117	-	-	-	-	ko00000	-	-	-	YqeY
SHD1_k127_4429992_0	861299.J421_3463	9.902e-185	588.0	COG1193@1|root,COG1193@2|Bacteria,1ZSWM@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity	mutS2	-	-	ko:K07456	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_V,Smr
SHD1_k127_4429992_3	861299.J421_3463	1.429e-82	284.0	COG1193@1|root,COG1193@2|Bacteria,1ZSWM@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity	mutS2	-	-	ko:K07456	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_V,Smr
SHD1_k127_4429992_1	861299.J421_3462	2.819e-164	546.0	COG0358@1|root,COG0358@2|Bacteria,1ZSTR@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,Toprim_2,Toprim_N,zf-CHC2
SHD1_k127_4429992_8	861299.J421_3461	0.0005446	45.0	COG1579@1|root,COG1579@2|Bacteria,1ZU01@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Zn-ribbon protein possibly nucleic acid-binding	-	-	-	ko:K07164	-	-	-	-	ko00000	-	-	-	-
SHD1_k127_4440708_2	861299.J421_0895	3.662e-09	60.0	COG0705@1|root,COG0705@2|Bacteria,1ZSWV@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
SHD1_k127_4440708_0	1379270.AUXF01000001_gene2718	6.355e-69	244.0	COG4454@1|root,COG4454@2|Bacteria,1ZTKN@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_4440708_1	1111069.TCCBUS3UF1_16010	1.545e-52	197.0	COG0077@1|root,COG0077@2|Bacteria,1WIGR@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	Prephenate dehydratase	pheA	-	4.2.1.51,5.4.99.5	ko:K04518,ko:K14170	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R00691,R01373,R01715	RC00360,RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,PDT
SHD1_k127_4440708_3	861299.J421_4440	0.0001746	44.0	COG2876@1|root,COG2876@2|Bacteria,1ZSPH@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	NeuB family	-	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
SHD1_k127_4444172_1	861299.J421_3858	1.214e-76	261.0	COG0218@1|root,COG0218@2|Bacteria,1ZTHF@142182|Gemmatimonadetes	142182|Gemmatimonadetes	D	Necessary for normal cell division and for the maintenance of normal septation	engB	-	-	ko:K03978	-	-	-	-	ko00000,ko03036	-	-	-	MMR_HSR1
SHD1_k127_4444172_0	861299.J421_3861	1.32e-117	385.0	COG0110@1|root,COG0110@2|Bacteria	2|Bacteria	S	O-acyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep,Hexapep_2
SHD1_k127_4444172_3	861299.J421_4104	0.0001927	55.0	COG5492@1|root,COG5492@2|Bacteria,1ZUE7@142182|Gemmatimonadetes	142182|Gemmatimonadetes	N	Bacterial Ig-like domain 2	-	-	-	-	-	-	-	-	-	-	-	-	Big_2
SHD1_k127_444686_4	861299.J421_2437	5.33e-08	54.0	COG1538@1|root,COG1538@2|Bacteria,1ZSUV@142182|Gemmatimonadetes	142182|Gemmatimonadetes	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
SHD1_k127_444686_0	1379270.AUXF01000002_gene1852	4.192e-109	365.0	COG1566@1|root,COG1566@2|Bacteria,1ZT4J@142182|Gemmatimonadetes	142182|Gemmatimonadetes	V	Biotin-lipoyl like	-	-	-	ko:K03543	-	M00701	-	-	ko00000,ko00002,ko02000	8.A.1.1	-	-	Biotin_lipoyl_2,HlyD_3
SHD1_k127_444686_1	861299.J421_2433	8.996e-82	285.0	COG2316@1|root,COG2316@2|Bacteria,1ZTH6@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	-	-	-	-	-	-	-	-	-	HD
SHD1_k127_444686_2	379066.GAU_0527	1.491e-69	246.0	COG1595@1|root,COG1595@2|Bacteria,1ZT0A@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	ECF sigma factor	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
SHD1_k127_444686_3	861299.J421_2430	7.996e-11	66.0	298DU@1|root,2ZVJ1@2|Bacteria,1ZU76@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_4448801_0	861299.J421_4038	6.926e-54	200.0	2B41E@1|root,31WRS@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_4448801_1	861299.J421_6214	2.406e-45	172.0	2DNAS@1|root,32WH6@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Phi_1
SHD1_k127_4452125_4	314230.DSM3645_23666	1.266e-30	128.0	COG0835@1|root,COG0835@2|Bacteria,2J076@203682|Planctomycetes	203682|Planctomycetes	NT	Two component signalling adaptor domain	-	-	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
SHD1_k127_4452125_5	335543.Sfum_1647	6.957e-07	60.0	COG0835@1|root,COG0835@2|Bacteria,1RAH1@1224|Proteobacteria,42S69@68525|delta/epsilon subdivisions,2X5TT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	NT	PFAM CheW domain protein	cheW	-	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
SHD1_k127_4452125_1	379066.GAU_1414	8.4e-95	324.0	COG2201@1|root,COG2201@2|Bacteria,1ZUFV@142182|Gemmatimonadetes	142182|Gemmatimonadetes	NT	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	-	-	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,Response_reg
SHD1_k127_4452125_3	1122947.FR7_3182	1.828e-31	132.0	COG1871@1|root,COG1871@2|Bacteria,1V70X@1239|Firmicutes,4H415@909932|Negativicutes	909932|Negativicutes	NT	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis	cheD	-	3.5.1.44	ko:K03411	ko02030,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheD
SHD1_k127_4452125_2	861299.J421_3062	1.463e-86	302.0	COG1352@1|root,COG1352@2|Bacteria	2|Bacteria	NT	protein-glutamate O-methyltransferase activity	cheR	-	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheR,CheR_N
SHD1_k127_4452125_0	1379270.AUXF01000005_gene674	2.332e-156	515.0	COG0457@1|root,COG0457@2|Bacteria,1ZSPN@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Domain of unknown function (DUF4388)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4388,TPR_16,TPR_2
SHD1_k127_4452125_6	1379270.AUXF01000005_gene673	0.0003215	45.0	COG0593@1|root,COG0593@2|Bacteria,1ZUFJ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	Bacterial dnaA  protein	-	-	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA
SHD1_k127_4456054_2	1150469.RSPPHO_01519	0.0001799	49.0	COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,2TQQM@28211|Alphaproteobacteria,2JV98@204441|Rhodospirillales	204441|Rhodospirillales	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
SHD1_k127_4456054_0	1379270.AUXF01000004_gene3318	1.294e-172	571.0	COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,1ZSP0@142182|Gemmatimonadetes	142182|Gemmatimonadetes	DM	Chain length determinant protein	-	-	-	ko:K16554	ko05111,map05111	-	-	-	ko00000,ko00001,ko02000	8.A.3.1	-	-	GNVR
SHD1_k127_4456054_1	1379270.AUXF01000004_gene3319	1.739e-136	441.0	COG2204@1|root,COG2204@2|Bacteria,1ZSZ6@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
SHD1_k127_4459943_0	379066.GAU_2857	2.134e-194	613.0	COG0183@1|root,COG0183@2|Bacteria,1ZSW1@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Thiolase, C-terminal domain	-	-	2.3.1.16	ko:K00632	ko00071,ko00280,ko00281,ko00362,ko00592,ko00642,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00362,map00592,map00642,map01100,map01110,map01120,map01130,map01212	M00087,M00113	R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000	-	-	-	Thiolase_C,Thiolase_N
SHD1_k127_4459943_1	1379270.AUXF01000001_gene2467	2.476e-78	272.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1ZT1A@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Enoyl-CoA hydratase/isomerase	fadJ	-	1.1.1.35,4.2.1.17,5.1.2.3	ko:K01782	ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212	M00032,M00087	R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094	RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
SHD1_k127_447772_4	215803.DB30_2681	3.741e-46	171.0	COG0667@1|root,COG0667@2|Bacteria,1MVEH@1224|Proteobacteria,42MDR@68525|delta/epsilon subdivisions,2WKUR@28221|Deltaproteobacteria,2YUKZ@29|Myxococcales	28221|Deltaproteobacteria	C	Aldo/keto reductase family	-	-	1.1.1.65	ko:K05275	ko00750,ko01100,ko01120,map00750,map01100,map01120	-	R01708	RC00116	ko00000,ko00001,ko01000	-	-	-	Aldo_ket_red
SHD1_k127_447772_3	1173024.KI912153_gene95	1.005e-61	220.0	COG0586@1|root,COG0586@2|Bacteria,1G39B@1117|Cyanobacteria,1JKHH@1189|Stigonemataceae	1117|Cyanobacteria	S	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
SHD1_k127_447772_0	1144275.COCOR_02843	6.257e-195	623.0	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,42MAH@68525|delta/epsilon subdivisions,2WJT7@28221|Deltaproteobacteria,2YVB7@29|Myxococcales	28221|Deltaproteobacteria	J	Amidase	-	-	3.5.1.4,6.3.5.6,6.3.5.7	ko:K01426,ko:K02433	ko00330,ko00360,ko00380,ko00627,ko00643,ko00970,ko01100,ko01120,map00330,map00360,map00380,map00627,map00643,map00970,map01100,map01120	-	R02540,R03096,R03180,R03905,R03909,R04212,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
SHD1_k127_447772_1	1380355.JNIJ01000071_gene5819	7.403e-80	280.0	COG0834@1|root,COG0834@2|Bacteria,1MWWZ@1224|Proteobacteria,2TU2F@28211|Alphaproteobacteria,3JVGF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	ET	Bacterial extracellular solute-binding proteins, family 3	-	-	-	ko:K16254	ko00680,ko01120,map00680,map01120	-	-	-	ko00000,ko00001	-	-	-	SBP_bac_3
SHD1_k127_447772_5	1443111.JASG01000004_gene1669	3.819e-09	68.0	COG1276@1|root,COG1276@2|Bacteria,1MXGC@1224|Proteobacteria,2TVGX@28211|Alphaproteobacteria,3ZYA3@60136|Sulfitobacter	28211|Alphaproteobacteria	P	Copper resistance protein D	ycnJ	-	-	ko:K07245,ko:K14166	-	-	-	-	ko00000,ko02000	9.B.62.1	-	-	CopC,CopD
SHD1_k127_447772_2	1379270.AUXF01000002_gene1586	2.376e-79	293.0	COG0515@1|root,COG0515@2|Bacteria	1379270.AUXF01000002_gene1586|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_4491130_0	1382356.JQMP01000001_gene1253	5.112e-67	237.0	COG3301@1|root,COG3301@2|Bacteria,2GA0G@200795|Chloroflexi,27YBQ@189775|Thermomicrobia	189775|Thermomicrobia	P	Polysulphide reductase, NrfD	-	-	-	-	-	-	-	-	-	-	-	-	NrfD
SHD1_k127_4491130_1	1192034.CAP_3491	9.715e-44	173.0	COG3058@1|root,COG3058@2|Bacteria,1NK06@1224|Proteobacteria,42VNJ@68525|delta/epsilon subdivisions,2WS9J@28221|Deltaproteobacteria,2Z2AD@29|Myxococcales	28221|Deltaproteobacteria	O	Necessary for formate dehydrogenase activity	fdhE	-	-	ko:K02380	-	-	-	-	ko00000	-	-	-	FdhE
SHD1_k127_4491130_2	479434.Sthe_3393	7.085e-21	99.0	29EH1@1|root,301EZ@2|Bacteria,2GBBR@200795|Chloroflexi,27YPJ@189775|Thermomicrobia	189775|Thermomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_4517784_4	861299.J421_0524	1.702e-12	73.0	COG0803@1|root,COG0803@2|Bacteria,1ZSS4@142182|Gemmatimonadetes	142182|Gemmatimonadetes	P	Belongs to the bacterial solute-binding protein 9 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF4175
SHD1_k127_4517784_2	1379270.AUXF01000004_gene2977	1.284e-81	280.0	COG1657@1|root,COG1657@2|Bacteria,1ZVAR@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Domain of unknown function (DUF4159)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4159
SHD1_k127_4517784_3	861299.J421_0526	2.566e-47	186.0	2C41Y@1|root,342S1@2|Bacteria,1ZU0P@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_4517784_1	861299.J421_5846	9.658e-153	511.0	COG0457@1|root,COG3629@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3629@2|Bacteria,COG5616@2|Bacteria	2|Bacteria	S	cAMP biosynthetic process	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	AAA_16,BTAD,TPR_12,Trans_reg_C
SHD1_k127_4517784_0	861299.J421_3669	2.116e-155	498.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
SHD1_k127_4521830_2	404589.Anae109_2327	2.53e-06	56.0	COG3506@1|root,COG5276@1|root,COG3506@2|Bacteria,COG5276@2|Bacteria,1Q8G3@1224|Proteobacteria,438JI@68525|delta/epsilon subdivisions,2X3U7@28221|Deltaproteobacteria,2YX4C@29|Myxococcales	28221|Deltaproteobacteria	U	ig-like, plexins, transcription factors	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,LVIVD,TIG
SHD1_k127_4521830_1	861299.J421_2642	1.543e-51	192.0	COG1651@1|root,COG1651@2|Bacteria,1ZTVX@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	Thioredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_4
SHD1_k127_4521830_0	1379270.AUXF01000004_gene3153	1.719e-57	210.0	COG1519@1|root,COG1519@2|Bacteria,1ZSXB@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase)	-	-	2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15	ko:K02527	ko00540,ko01100,map00540,map01100	M00060,M00080	R04658,R05074,R09763	RC00009,RC00077,RC00247	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT30	-	Glycos_transf_N
SHD1_k127_4535111_3	1463841.JOIR01000013_gene2264	1.264e-51	188.0	COG0384@1|root,COG0384@2|Bacteria	2|Bacteria	S	isomerase activity	-	-	-	ko:K07054	-	-	-	-	ko00000	-	-	-	PhzC-PhzF
SHD1_k127_4535111_4	1298858.AUEL01000002_gene1561	5.831e-30	122.0	COG0640@1|root,COG0640@2|Bacteria,1N8QA@1224|Proteobacteria,2UC02@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	ybzH	-	-	-	-	-	-	-	-	-	-	-	HTH_20
SHD1_k127_4535111_1	861299.J421_6089	6.349e-90	315.0	COG1073@1|root,COG1680@1|root,COG1073@2|Bacteria,COG1680@2|Bacteria,1ZU86@142182|Gemmatimonadetes	2|Bacteria	V	Domain of unknown function (DUF3471)	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Beta-lactamase,DUF3471,Hydrolase_4
SHD1_k127_4535111_0	861299.J421_2136	6.406e-258	810.0	COG0405@1|root,COG0405@2|Bacteria,1ZUCB@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
SHD1_k127_4535111_2	1265503.KB905183_gene4396	1.044e-57	229.0	COG1835@1|root,COG1835@2|Bacteria,1MV2W@1224|Proteobacteria,1RQS2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
SHD1_k127_4535111_5	1347086.CCBA010000012_gene2030	0.0006089	44.0	2AWWM@1|root,31NU5@2|Bacteria,1TZQ8@1239|Firmicutes,4II4F@91061|Bacilli,1ZJ4J@1386|Bacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_4537927_3	1122137.AQXF01000003_gene2088	7.419e-100	336.0	COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,2U0BD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
SHD1_k127_4537927_5	653733.Selin_0993	7.818e-48	175.0	COG3169@1|root,COG3169@2|Bacteria	2|Bacteria	S	Protein conserved in bacteria	-	-	-	ko:K09922	-	-	-	-	ko00000	-	-	-	DMT_6
SHD1_k127_4537927_2	861299.J421_2914	5.516e-100	338.0	COG1606@1|root,COG1606@2|Bacteria	2|Bacteria	L	tRNA processing	-	-	-	ko:K06864	-	-	-	-	ko00000	-	-	-	Asn_synthase,NAD_synthase
SHD1_k127_4537927_8	1382356.JQMP01000004_gene448	1.243e-26	116.0	COG1514@1|root,COG1514@2|Bacteria,2G76S@200795|Chloroflexi,27YFE@189775|Thermomicrobia	189775|Thermomicrobia	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	-	-	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
SHD1_k127_4537927_6	861299.J421_2916	3.09e-35	142.0	28R18@1|root,2ZDFV@2|Bacteria,1ZU2V@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_4537927_1	379066.GAU_1166	5.275e-205	649.0	COG2204@1|root,COG2204@2|Bacteria,1ZT50@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
SHD1_k127_4537927_7	379066.GAU_1167	6.577e-30	123.0	2FCTB@1|root,344W9@2|Bacteria,1ZU4K@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_4537927_0	861299.J421_2920	2.815e-276	854.0	COG1012@1|root,COG1012@2|Bacteria,1ZST9@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Aldehyde dehydrogenase family	-	-	-	ko:K22187	ko00040,map00040	-	R11768	RC00080	ko00000,ko00001,ko01000	-	-	-	Aldedh
SHD1_k127_4537927_4	861299.J421_2921	1.348e-89	303.0	COG0681@1|root,COG0681@2|Bacteria,1ZTQ3@142182|Gemmatimonadetes	142182|Gemmatimonadetes	U	Signal peptidase, peptidase S26	-	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
SHD1_k127_4546917_0	861299.J421_3942	2.015e-141	455.0	COG1208@1|root,COG1208@2|Bacteria,1ZSYR@142182|Gemmatimonadetes	142182|Gemmatimonadetes	JM	Nucleotidyl transferase	-	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
SHD1_k127_4546917_1	1379270.AUXF01000003_gene3432	2.729e-58	205.0	COG0662@1|root,COG0662@2|Bacteria,1ZTKY@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	Mannose-6-phosphate isomerase	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
SHD1_k127_4547161_11	861299.J421_0523	4.605e-33	137.0	2FFKA@1|root,347HR@2|Bacteria,1ZU3F@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_4547161_2	861299.J421_0524	2.852e-142	484.0	COG0803@1|root,COG0803@2|Bacteria,1ZSS4@142182|Gemmatimonadetes	142182|Gemmatimonadetes	P	Belongs to the bacterial solute-binding protein 9 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF4175
SHD1_k127_4547161_8	861299.J421_0525	1.105e-98	325.0	2ENB7@1|root,33FYV@2|Bacteria,1ZSVA@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Domain of unknown function (DUF4159)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4159
SHD1_k127_4547161_10	861299.J421_0526	6.703e-59	222.0	2C41Y@1|root,342S1@2|Bacteria,1ZU0P@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_4547161_3	379066.GAU_0921	2.49e-139	457.0	COG0123@1|root,COG0123@2|Bacteria,1ZSKN@142182|Gemmatimonadetes	142182|Gemmatimonadetes	BQ	Histone deacetylase domain	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
SHD1_k127_4547161_5	861299.J421_2823	8.695e-130	422.0	COG0515@1|root,COG0515@2|Bacteria,1ZTFI@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
SHD1_k127_4547161_4	861299.J421_2824	1.111e-133	441.0	COG4948@1|root,COG4948@2|Bacteria,1ZSKY@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	-	5.1.1.20	ko:K19802	-	-	R10938	RC03309	ko00000,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
SHD1_k127_4547161_0	1379270.AUXF01000004_gene2971	4.32e-277	872.0	COG1198@1|root,COG1198@2|Bacteria,1ZTE9@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C
SHD1_k127_4547161_1	246197.MXAN_0421	1.998e-181	574.0	COG1915@1|root,COG1915@2|Bacteria,1PZ72@1224|Proteobacteria,42MME@68525|delta/epsilon subdivisions,2WJSV@28221|Deltaproteobacteria,2YYT4@29|Myxococcales	28221|Deltaproteobacteria	S	PFAM LOR SDH bifunctional enzyme conserved region	-	-	-	-	-	-	-	-	-	-	-	-	Saccharop_dh_N
SHD1_k127_4547161_15	861299.J421_2827	5.772e-10	69.0	2FCS2@1|root,344V7@2|Bacteria,1ZU5A@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_4547161_6	1232410.KI421421_gene3566	7.3e-107	368.0	COG1524@1|root,COG1524@2|Bacteria,1QX9K@1224|Proteobacteria	1224|Proteobacteria	S	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
SHD1_k127_4547161_9	861299.J421_2831	5.774e-92	308.0	COG0785@1|root,COG0785@2|Bacteria,1ZTJC@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	Cytochrome C biogenesis protein transmembrane region	-	-	-	ko:K06196	-	-	-	-	ko00000,ko02000	5.A.1.2	-	-	DsbD
SHD1_k127_4547161_14	861299.J421_2832	5.749e-23	102.0	COG0745@1|root,COG0745@2|Bacteria	861299.J421_2832|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_4547161_7	861299.J421_2833	1.7e-100	334.0	COG0642@1|root,COG2205@2|Bacteria,1ZTAI@142182|Gemmatimonadetes	861299.J421_2833|-	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_4547161_13	861299.J421_2835	5.836e-26	117.0	2EVUZ@1|root,33P8Q@2|Bacteria,1ZTJQ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_4556390_3	1379270.AUXF01000002_gene1120	1.584e-68	239.0	COG0705@1|root,COG0705@2|Bacteria,1ZSWV@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
SHD1_k127_4556390_6	760568.Desku_1420	0.0004795	50.0	COG0602@1|root,COG0602@2|Bacteria,1TQ58@1239|Firmicutes,2499R@186801|Clostridia,261XM@186807|Peptococcaceae	186801|Clostridia	H	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds	queE	-	4.3.99.3	ko:K10026	ko00790,ko01100,map00790,map01100	-	R10002	RC02989	ko00000,ko00001,ko01000,ko03016	-	-	-	Fer4_12,Fer4_14,Radical_SAM
SHD1_k127_4556390_2	1379270.AUXF01000002_gene1121	3.04e-115	381.0	COG1181@1|root,COG1181@2|Bacteria,1ZTFQ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
SHD1_k127_4556390_5	861299.J421_0898	1.703e-29	125.0	COG0810@1|root,COG0810@2|Bacteria,1ZV4A@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	Gram-negative bacterial TonB protein C-terminal	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
SHD1_k127_4556390_0	861299.J421_0897	1.853e-223	706.0	COG0031@1|root,COG0031@2|Bacteria,1ZTA6@142182|Gemmatimonadetes	142182|Gemmatimonadetes	EK	Domain in cystathionine beta-synthase and other proteins.	-	-	4.2.1.22	ko:K01697	ko00260,ko00270,ko01100,ko01130,ko01230,map00260,map00270,map01100,map01130,map01230	M00035,M00338	R00891,R01290,R04942	RC00056,RC00069,RC00256,RC00489,RC01246	ko00000,ko00001,ko00002,ko01000	-	-	-	CBS,PALP
SHD1_k127_4556390_4	401053.AciPR4_3843	5.062e-45	169.0	2ENUK@1|root,33GFP@2|Bacteria,3Y929@57723|Acidobacteria,2JNNI@204432|Acidobacteriia	204432|Acidobacteriia	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
SHD1_k127_4556390_1	861299.J421_1125	4.008e-168	534.0	COG0208@1|root,COG0208@2|Bacteria,1ZTAE@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Fatty acid desaturase	-	-	1.14.19.11,1.14.19.2,1.14.19.26	ko:K03921	ko00061,ko01040,ko01212,map00061,map01040,map01212	-	R03370,R08161,R11108,R11109	RC00917	ko00000,ko00001,ko01000,ko01004	-	-	-	FA_desaturase_2
SHD1_k127_4565325_5	1453503.AU05_20560	8.089e-24	104.0	COG1262@1|root,COG1262@2|Bacteria,1MUNC@1224|Proteobacteria,1RQI4@1236|Gammaproteobacteria,1YJ15@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	DinB superfamily	egtB	-	-	-	-	-	-	-	-	-	-	-	DinB_2,FGE-sulfatase
SHD1_k127_4565325_0	240015.ACP_1229	2.357e-146	478.0	COG1249@1|root,COG1249@2|Bacteria	2|Bacteria	C	cell redox homeostasis	gshR	-	1.8.1.7	ko:K00383	ko00480,ko04918,map00480,map04918	-	R00094,R00115	RC00011	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
SHD1_k127_4565325_2	1173024.KI912150_gene1475	1.265e-114	383.0	28HGI@1|root,2Z7SC@2|Bacteria,1FZZQ@1117|Cyanobacteria,1JHV5@1189|Stigonemataceae	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_4565325_4	401053.AciPR4_4209	5.571e-33	138.0	COG5207@1|root,COG5207@2|Bacteria,3Y5QE@57723|Acidobacteria	57723|Acidobacteria	O	Zn-finger in ubiquitin-hydrolases and other protein	-	-	-	-	-	-	-	-	-	-	-	-	zf-UBP
SHD1_k127_4565325_1	1220589.CD32_18595	6.426e-116	382.0	COG0095@1|root,COG0095@2|Bacteria,1TQ5U@1239|Firmicutes,4H9P6@91061|Bacilli,3IW0Y@400634|Lysinibacillus	91061|Bacilli	H	Lipoate-protein ligase	lplJ	GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016779,GO:0016874,GO:0016879,GO:0016979,GO:0017118,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:0140096,GO:1901564	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB,Lip_prot_lig_C
SHD1_k127_4565325_3	861299.J421_6133	8.069e-59	216.0	COG0189@1|root,COG0189@2|Bacteria	2|Bacteria	HJ	Glutathione synthase Ribosomal protein S6 modification enzyme (Glutaminyl transferase)	dcsG	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	GSH-S_ATP,RimK
SHD1_k127_4572741_2	234267.Acid_6457	6.281e-77	265.0	COG1914@1|root,COG1914@2|Bacteria	2|Bacteria	P	metal ion transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	Nramp
SHD1_k127_4572741_3	234621.RER_16810	8.681e-26	123.0	COG1950@1|root,COG1950@2|Bacteria,2IHP5@201174|Actinobacteria,4G28G@85025|Nocardiaceae	201174|Actinobacteria	S	Mycobacterial 4 TMS phage holin, superfamily IV	-	-	-	ko:K08972	-	-	-	-	ko00000	-	-	-	Phage_holin_4_2
SHD1_k127_4572741_1	306281.AJLK01000103_gene3381	9.926e-135	442.0	COG0477@1|root,COG0477@2|Bacteria,1G1NG@1117|Cyanobacteria,1JKCQ@1189|Stigonemataceae	1117|Cyanobacteria	EGP	Transmembrane secretion effector	-	-	-	ko:K08225	-	-	-	-	ko00000,ko02000	2.A.1.38	-	-	MFS_3
SHD1_k127_4572741_0	1123242.JH636434_gene3744	8.249e-154	505.0	COG1574@1|root,COG1574@2|Bacteria,2IXY4@203682|Planctomycetes	203682|Planctomycetes	Q	PFAM amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
SHD1_k127_4572741_5	522306.CAP2UW1_2372	2.655e-07	59.0	2AEG4@1|root,314B7@2|Bacteria,1Q0KY@1224|Proteobacteria,2W5FZ@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_4572741_4	68219.JNXI01000010_gene5732	9.593e-15	75.0	2BMG4@1|root,32G0U@2|Bacteria,2H148@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_457303_5	1210884.HG799463_gene9891	7.585e-42	158.0	COG0454@1|root,COG0456@2|Bacteria,2J1K9@203682|Planctomycetes	203682|Planctomycetes	K	acetyltransferase	-	-	-	ko:K03827	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_10
SHD1_k127_457303_6	931627.MycrhDRAFT_3993	6.096e-32	132.0	COG3059@1|root,COG3059@2|Bacteria,2IIYH@201174|Actinobacteria,2398Q@1762|Mycobacteriaceae	201174|Actinobacteria	S	Protein of unknown function, DUF417	-	-	-	-	-	-	-	-	-	-	-	-	DUF417
SHD1_k127_457303_1	861299.J421_3887	2.637e-90	313.0	COG2706@1|root,COG2706@2|Bacteria	2|Bacteria	G	6-phosphogluconolactonase activity	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
SHD1_k127_457303_3	1379270.AUXF01000007_gene1033	3.412e-48	183.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
SHD1_k127_457303_0	102125.Xen7305DRAFT_00047600	1.42e-93	324.0	COG0666@1|root,COG0666@2|Bacteria,1G52C@1117|Cyanobacteria	1117|Cyanobacteria	S	response to abiotic stimulus	-	-	-	-	-	-	-	-	-	-	-	-	Ank_2
SHD1_k127_457303_2	1238182.C882_0658	2.854e-69	251.0	COG0845@1|root,COG0845@2|Bacteria,1Q10W@1224|Proteobacteria,2TSC8@28211|Alphaproteobacteria,2JRIP@204441|Rhodospirillales	204441|Rhodospirillales	M	HlyD family secretion protein	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	HlyD_3
SHD1_k127_457303_4	111781.Lepto7376_2080	3.464e-45	169.0	COG0577@1|root,COG0577@2|Bacteria,1G0Z7@1117|Cyanobacteria,1H9BF@1150|Oscillatoriales	1117|Cyanobacteria	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
SHD1_k127_4575298_1	379066.GAU_1229	2.065e-181	583.0	COG1028@1|root,COG1028@2|Bacteria,1ZT0F@142182|Gemmatimonadetes	142182|Gemmatimonadetes	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
SHD1_k127_4575298_7	1038860.AXAP01000034_gene3878	1.698e-18	89.0	2E328@1|root,32Y2G@2|Bacteria,1N9RI@1224|Proteobacteria,2UFJ4@28211|Alphaproteobacteria,3K0VA@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_4575298_4	457396.CSBG_00260	8.37e-52	201.0	COG4412@1|root,COG4412@2|Bacteria	2|Bacteria	S	peptidase activity, acting on L-amino acid peptides	ina	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Peptidase_M6
SHD1_k127_4575298_5	861299.J421_0548	2.169e-50	185.0	COG5483@1|root,COG5483@2|Bacteria	2|Bacteria	S	Protein of unknown function, DUF488	MA20_09495	-	-	-	-	-	-	-	-	-	-	-	DUF488
SHD1_k127_4575298_9	1038859.AXAU01000005_gene5171	2.908e-13	72.0	2E7PS@1|root,3325B@2|Bacteria,1N7R7@1224|Proteobacteria,2UFCM@28211|Alphaproteobacteria,3K0ZR@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_4575298_6	861299.J421_1636	4.763e-44	165.0	2B1QU@1|root,31U6H@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF3224)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3224
SHD1_k127_4575298_3	861299.J421_1097	4.17e-53	192.0	COG2318@1|root,COG2318@2|Bacteria,1ZV4X@142182|Gemmatimonadetes	2|Bacteria	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB,DinB_2
SHD1_k127_4575298_0	1267534.KB906760_gene1359	0.0	1009.0	COG2366@1|root,COG2366@2|Bacteria,3Y38M@57723|Acidobacteria,2JM6Q@204432|Acidobacteriia	204432|Acidobacteriia	S	Penicillin amidase	-	-	-	-	-	-	-	-	-	-	-	-	Penicil_amidase
SHD1_k127_4575298_2	483219.LILAB_20790	5.682e-89	299.0	COG3361@1|root,COG3361@2|Bacteria	2|Bacteria	S	conserved protein (COG2071)	-	-	-	ko:K09166	-	-	-	-	ko00000	-	-	-	DUF2071
SHD1_k127_4575298_8	240015.ACP_0152	2.467e-13	70.0	COG2318@1|root,COG2318@2|Bacteria,3Y5DP@57723|Acidobacteria,2JN3K@204432|Acidobacteriia	204432|Acidobacteriia	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
SHD1_k127_4589490_1	861299.J421_2940	1.23e-123	408.0	COG0793@1|root,COG0793@2|Bacteria,1ZSUF@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	tail specific protease	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ,Peptidase_S41
SHD1_k127_4589490_3	383372.Rcas_3715	2.245e-31	134.0	COG5495@1|root,COG5495@2|Bacteria,2G6F3@200795|Chloroflexi,377DR@32061|Chloroflexia	32061|Chloroflexia	S	PFAM NADP oxidoreductase coenzyme F420-dependent	-	-	-	-	-	-	-	-	-	-	-	-	DUF2520,Rossmann-like
SHD1_k127_4589490_2	379066.GAU_1190	1.476e-43	168.0	COG2834@1|root,COG2834@2|Bacteria,1ZTXG@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	Outer membrane lipoprotein carrier protein LolA	-	-	-	ko:K03634	-	-	-	-	ko00000	-	-	-	LolA
SHD1_k127_4589490_0	379066.GAU_1191	9.637e-151	483.0	COG2876@1|root,COG2876@2|Bacteria,1ZTB0@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	NeuB family	-	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
SHD1_k127_4589490_4	861299.J421_2943	3.47e-20	91.0	COG1234@1|root,COG1234@2|Bacteria,1ZT5E@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
SHD1_k127_4600615_1	379066.GAU_2372	3.927e-73	253.0	COG0855@1|root,COG0855@2|Bacteria,1ZT5F@142182|Gemmatimonadetes	142182|Gemmatimonadetes	P	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
SHD1_k127_4600615_0	861299.J421_3845	1.108e-112	370.0	COG0306@1|root,COG0306@2|Bacteria,1ZSZ2@142182|Gemmatimonadetes	142182|Gemmatimonadetes	P	Phosphate transporter family	-	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
SHD1_k127_4628712_4	861299.J421_4356	4.076e-96	319.0	COG1136@1|root,COG1136@2|Bacteria,1ZUKE@142182|Gemmatimonadetes	142182|Gemmatimonadetes	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SHD1_k127_4628712_1	861299.J421_4355	1.507e-190	608.0	2AETJ@1|root,314QN@2|Bacteria,1ZU8F@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_4628712_6	266117.Rxyl_1054	7.36e-61	218.0	COG0400@1|root,COG0400@2|Bacteria,2INMY@201174|Actinobacteria,4CTAJ@84995|Rubrobacteria	84995|Rubrobacteria	S	Dienelactone hydrolase family	-	-	-	ko:K06999	-	-	-	-	ko00000	-	-	-	DLH
SHD1_k127_4628712_2	861299.J421_0859	7.176e-142	456.0	COG0346@1|root,COG0346@2|Bacteria,1ZTUT@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	ko:K15975	-	-	-	-	ko00000	-	-	-	Glyoxalase
SHD1_k127_4628712_5	358681.BBR47_46810	3.458e-80	282.0	COG0596@1|root,COG0596@2|Bacteria,1UJJZ@1239|Firmicutes,4ITAM@91061|Bacilli,26X8K@186822|Paenibacillaceae	91061|Bacilli	S	Releases the N-terminal proline from various substrates	-	-	3.4.11.5	ko:K01259	ko00330,map00330	-	R00135	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Abhydrolase_1
SHD1_k127_4628712_8	243090.RB974	1.067e-48	178.0	COG1671@1|root,COG1671@2|Bacteria,2IZRB@203682|Planctomycetes	203682|Planctomycetes	S	Belongs to the UPF0178 family	-	-	-	ko:K09768	-	-	-	-	ko00000	-	-	-	DUF188
SHD1_k127_4628712_9	1379270.AUXF01000002_gene1442	6.874e-40	153.0	COG1846@1|root,COG1846@2|Bacteria,1ZTUS@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	ko:K15973	-	-	-	-	ko00000,ko03000	-	-	-	MarR_2
SHD1_k127_4628712_3	861299.J421_4352	3.997e-124	405.0	COG1801@1|root,COG1801@2|Bacteria	2|Bacteria	L	Protein of unknown function DUF72	yecE	-	-	-	-	-	-	-	-	-	-	-	DUF72
SHD1_k127_4628712_7	861299.J421_4349	1.78e-55	203.0	COG3346@1|root,COG3346@2|Bacteria,1ZTTS@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	SURF1 family	-	-	-	ko:K14998	-	-	-	-	ko00000,ko03029	3.D.4.8	-	-	SURF1
SHD1_k127_4628712_0	290397.Adeh_1417	1.516e-205	657.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42PMK@68525|delta/epsilon subdivisions,2X5G7@28221|Deltaproteobacteria,2Z35F@29|Myxococcales	28221|Deltaproteobacteria	C	Acyl-CoA dehydrogenase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
SHD1_k127_4628712_11	861299.J421_1402	2.629e-17	94.0	COG2091@1|root,COG2091@2|Bacteria,1ZUPU@142182|Gemmatimonadetes	2|Bacteria	H	Carbohydrate family 9 binding domain-like	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
SHD1_k127_4640924_5	292563.Cyast_1065	6.869e-20	92.0	COG0591@1|root,COG0591@2|Bacteria,1G1JV@1117|Cyanobacteria	1117|Cyanobacteria	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	putP	-	-	-	-	-	-	-	-	-	-	-	SSF
SHD1_k127_4640924_1	379066.GAU_0937	3.636e-142	475.0	COG1472@1|root,COG1472@2|Bacteria,1ZST8@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	Glycosyl hydrolase family 3 N terminal domain	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Glyco_hydro_3
SHD1_k127_4640924_2	861299.J421_2839	6.324e-131	429.0	COG2377@1|root,COG2377@2|Bacteria,1ZSZI@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling	anmK	-	2.7.1.170	ko:K09001	-	-	-	-	ko00000,ko01000	-	-	-	AnmK
SHD1_k127_4640924_3	247490.KSU1_D0539	3.761e-83	286.0	COG2103@1|root,COG2103@2|Bacteria,2IWTZ@203682|Planctomycetes	203682|Planctomycetes	G	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate	murQ	-	4.2.1.126	ko:K07106	ko00520,ko01100,map00520,map01100	-	R08555	RC00397,RC00746	ko00000,ko00001,ko01000	-	-	-	SIS,SIS_2
SHD1_k127_4640924_0	861299.J421_2837	9.81e-181	586.0	COG0405@1|root,COG0405@2|Bacteria,1ZT0E@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
SHD1_k127_4640924_4	861299.J421_2835	2.511e-21	96.0	2EVUZ@1|root,33P8Q@2|Bacteria,1ZTJQ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_4652771_0	861299.J421_0823	4.214e-64	226.0	COG2514@1|root,COG2514@2|Bacteria,1ZTDT@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	1.13.11.2	ko:K07104	ko00361,ko00362,ko00622,ko00643,ko01100,ko01120,ko01220,map00361,map00362,map00622,map00643,map01100,map01120,map01220	M00569	R00816,R04089,R05295,R05404,R05406,R07795	RC00387,RC00643,RC01075,RC01364,RC01914	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase
SHD1_k127_4652771_2	861299.J421_0832	9.247e-32	131.0	COG2259@1|root,COG2259@2|Bacteria	2|Bacteria	S	methylamine metabolic process	catD	-	-	ko:K15977	-	-	-	-	ko00000	-	-	-	DoxX
SHD1_k127_4652771_1	1144275.COCOR_06532	4.142e-47	172.0	COG0251@1|root,COG0251@2|Bacteria,1RES6@1224|Proteobacteria,435VN@68525|delta/epsilon subdivisions,2X0B9@28221|Deltaproteobacteria,2Z1FV@29|Myxococcales	28221|Deltaproteobacteria	J	Endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
SHD1_k127_4655779_1	376733.IT41_06990	3.335e-18	85.0	COG3360@1|root,COG3360@2|Bacteria,1N6YT@1224|Proteobacteria,2UFPQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Dodecin	-	-	-	ko:K09165	-	-	-	-	ko00000	-	-	-	Dodecin
SHD1_k127_4655779_2	1266925.JHVX01000001_gene2468	3.825e-11	64.0	2EFZF@1|root,339RM@2|Bacteria,1NH6S@1224|Proteobacteria,2W8JG@28216|Betaproteobacteria,373T2@32003|Nitrosomonadales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_4655779_3	592029.DDD_3351	7.448e-07	53.0	COG3237@1|root,COG3237@2|Bacteria,4PDUZ@976|Bacteroidetes,1IE8H@117743|Flavobacteriia,3HM8M@363408|Nonlabens	976|Bacteroidetes	S	CsbD-like	-	-	-	-	-	-	-	-	-	-	-	-	CsbD
SHD1_k127_4655779_0	883126.HMPREF9710_05182	1.31e-33	133.0	COG3040@1|root,COG3040@2|Bacteria,1RDAI@1224|Proteobacteria,2VRSU@28216|Betaproteobacteria,474F4@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Lipocalin-like domain	blc	-	-	ko:K03098	-	-	-	-	ko00000,ko04147	-	-	-	Lipocalin_2
SHD1_k127_4660162_2	1242864.D187_004703	5.644e-05	45.0	COG1090@1|root,COG1090@2|Bacteria,1MUB4@1224|Proteobacteria,42QUU@68525|delta/epsilon subdivisions,2WKRY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	epimerase dehydratase	-	-	-	ko:K07071	-	-	-	-	ko00000	-	-	-	DUF1731,Epimerase
SHD1_k127_4660162_1	63737.Npun_F6250	4.403e-89	303.0	COG1028@1|root,COG1028@2|Bacteria,1G3Y3@1117|Cyanobacteria,1HRRJ@1161|Nostocales	1117|Cyanobacteria	IQ	PFAM Short-chain dehydrogenase reductase SDR	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
SHD1_k127_4660162_0	861299.J421_1387	4.466e-129	448.0	COG0642@1|root,COG2203@1|root,COG2203@2|Bacteria,COG2205@2|Bacteria	2|Bacteria	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	DUF4118,GAF,GAF_2,GAF_3,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg
SHD1_k127_4688648_2	118166.JH976537_gene2717	3.799e-48	196.0	COG0642@1|root,COG2202@1|root,COG4251@1|root,COG2202@2|Bacteria,COG2205@2|Bacteria,COG4251@2|Bacteria,1G09B@1117|Cyanobacteria,1H71H@1150|Oscillatoriales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,PAS_3,PAS_4,Response_reg
SHD1_k127_4688648_1	99598.Cal7507_4992	1.28e-84	306.0	COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1G17N@1117|Cyanobacteria,1HKKR@1161|Nostocales	1117|Cyanobacteria	T	PFAM Adenylate and Guanylate cyclase catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc
SHD1_k127_4688648_0	1379270.AUXF01000005_gene642	1.029e-161	533.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria	2|Bacteria	S	cAMP biosynthetic process	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
SHD1_k127_4693354_4	452637.Oter_1692	2.64e-19	94.0	COG1520@1|root,COG1520@2|Bacteria,46T0C@74201|Verrucomicrobia,3K9Y4@414999|Opitutae	2|Bacteria	S	PFAM Pyrrolo-quinoline quinone	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PQQ_2,PQQ_3,Pkinase
SHD1_k127_4693354_2	216595.PFLU_3350	4.611e-69	241.0	COG2335@1|root,COG2335@2|Bacteria,1RD06@1224|Proteobacteria,1RSMY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Secreted and surface protein containing fasciclin-like repeats	-	-	-	ko:K19519	-	-	-	-	ko00000,ko04516	-	-	-	Fasciclin,Lipoprotein_15
SHD1_k127_4693354_0	1089550.ATTH01000001_gene363	4.603e-201	659.0	COG1629@1|root,COG4771@2|Bacteria,4NFJJ@976|Bacteroidetes,1FJXK@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	P	TonB dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
SHD1_k127_4693354_1	861299.J421_1652	6.863e-122	407.0	COG0628@1|root,COG0628@2|Bacteria	2|Bacteria	D	permease	yhhT	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
SHD1_k127_4696319_1	861299.J421_2500	4.158e-28	124.0	COG0642@1|root,COG0642@2|Bacteria,1ZTZE@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
SHD1_k127_4696319_0	379066.GAU_0578	2.575e-101	334.0	COG2204@1|root,COG2204@2|Bacteria,1ZSZ6@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
SHD1_k127_4702824_1	861299.J421_6082	7.778e-56	204.0	COG3375@1|root,COG3375@2|Bacteria,1ZUBU@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	carboxylic acid catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_4702824_0	861299.J421_5963	9.036e-164	536.0	COG4948@1|root,COG4948@2|Bacteria,1ZUQN@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB)	-	-	4.2.1.113	ko:K02549	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R04031	RC01053	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
SHD1_k127_4702824_2	861299.J421_5962	2.725e-48	185.0	COG1473@1|root,COG1473@2|Bacteria,1ZUHE@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
SHD1_k127_4711009_3	861299.J421_3967	1.496e-101	334.0	COG4974@1|root,COG4974@2|Bacteria,1ZT3T@142182|Gemmatimonadetes	142182|Gemmatimonadetes	D	Phage integrase, N-terminal SAM-like domain	xerC	-	-	ko:K03733	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
SHD1_k127_4711009_4	861299.J421_3964	1.159e-78	268.0	COG5405@1|root,COG5405@2|Bacteria,1ZSVH@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery	hslV	-	3.4.25.2	ko:K01419	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Proteasome
SHD1_k127_4711009_0	379066.GAU_2503	3.389e-223	701.0	COG1220@1|root,COG1220@2|Bacteria,1ZSVP@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis	hslU	-	-	ko:K03667	-	-	-	-	ko00000,ko03110	-	-	-	AAA_2,ClpB_D2-small
SHD1_k127_4711009_2	1121924.ATWH01000010_gene857	9.393e-106	374.0	COG1168@1|root,COG1168@2|Bacteria,2GJFQ@201174|Actinobacteria,4FKGR@85023|Microbacteriaceae	201174|Actinobacteria	E	Aminotransferase class I and II	metC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	4.4.1.8	ko:K14155	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	-	R00782,R01286,R02408,R04941	RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
SHD1_k127_4711009_1	861299.J421_3960	5.037e-158	504.0	COG0078@1|root,COG0078@2|Bacteria,1ZT4K@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	-	-	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
SHD1_k127_4711009_9	1122182.KB903825_gene447	3.21e-08	66.0	COG3903@1|root,COG3903@2|Bacteria,2GIRS@201174|Actinobacteria,4DGXQ@85008|Micromonosporales	201174|Actinobacteria	K	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	HTH_31,NB-ARC,TPR_10,TPR_12,TPR_7
SHD1_k127_4711009_5	379066.GAU_0766	6.817e-75	260.0	COG2207@1|root,COG3749@1|root,COG2207@2|Bacteria,COG3749@2|Bacteria,1ZUCG@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
SHD1_k127_4711009_6	861299.J421_3956	1.784e-61	222.0	COG0521@1|root,COG0521@2|Bacteria,1ZU2Z@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Probable molybdopterin binding domain	-	-	2.7.7.75	ko:K03831	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09726	RC00002	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth
SHD1_k127_4711009_7	379066.GAU_2498	1.804e-53	198.0	COG2204@1|root,COG2204@2|Bacteria,1ZSWY@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Sigma54_activat
SHD1_k127_4725512_1	483219.LILAB_14520	4.295e-122	397.0	COG1788@1|root,COG1788@2|Bacteria,1NGS5@1224|Proteobacteria,42S03@68525|delta/epsilon subdivisions,2WNW5@28221|Deltaproteobacteria,2YZ59@29|Myxococcales	28221|Deltaproteobacteria	I	Coenzyme A transferase	-	-	2.8.3.12	ko:K01039	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
SHD1_k127_4725512_2	1278073.MYSTI_01992	6.999e-98	325.0	COG2057@1|root,COG2057@2|Bacteria,1MY3S@1224|Proteobacteria,42R4B@68525|delta/epsilon subdivisions,2WMZN@28221|Deltaproteobacteria,2YX8R@29|Myxococcales	28221|Deltaproteobacteria	I	Coenzyme A transferase	-	-	2.8.3.12	ko:K01040	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
SHD1_k127_4725512_3	861299.J421_4004	4.471e-65	230.0	COG1266@1|root,COG1266@2|Bacteria	2|Bacteria	V	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
SHD1_k127_4725512_0	1163409.UUA_08346	3.404e-148	485.0	COG0823@1|root,COG0823@2|Bacteria,1MWYK@1224|Proteobacteria,1RXYW@1236|Gammaproteobacteria,1XD03@135614|Xanthomonadales	135614|Xanthomonadales	U	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	PD40
SHD1_k127_4742044_0	861299.J421_2683	6.89e-78	273.0	COG0747@1|root,COG0747@2|Bacteria,1ZTBU@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
SHD1_k127_4742044_1	861299.J421_2682	1.047e-69	246.0	COG0601@1|root,COG0601@2|Bacteria,1ZTP1@142182|Gemmatimonadetes	142182|Gemmatimonadetes	U	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
SHD1_k127_4764027_2	760192.Halhy_1783	1.123e-42	166.0	2DI69@1|root,30258@2|Bacteria,4PJ1K@976|Bacteroidetes,1IZ7W@117747|Sphingobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_4764027_0	118173.KB235910_gene4617	1.666e-98	327.0	COG1136@1|root,COG1136@2|Bacteria,1G4IP@1117|Cyanobacteria,1HA7Y@1150|Oscillatoriales	1117|Cyanobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SHD1_k127_4764027_1	489825.LYNGBM3L_63180	4.191e-76	266.0	COG0577@1|root,COG0577@2|Bacteria,1G0Z7@1117|Cyanobacteria,1H9BF@1150|Oscillatoriales	1117|Cyanobacteria	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
SHD1_k127_4764110_4	861299.J421_2665	5.428e-19	101.0	COG0810@1|root,COG1629@1|root,COG0810@2|Bacteria,COG1629@2|Bacteria,1ZTMF@142182|Gemmatimonadetes	142182|Gemmatimonadetes	MP	Gram-negative bacterial TonB protein C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_C
SHD1_k127_4764110_0	379066.GAU_0710	2.392e-155	495.0	COG0568@1|root,COG0568@2|Bacteria,1ZTCX@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
SHD1_k127_4764110_2	159450.NH14_07855	8.154e-47	172.0	COG4319@1|root,COG4319@2|Bacteria,1RII1@1224|Proteobacteria,2VXCZ@28216|Betaproteobacteria,1K8QB@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Domain of unknown function (DUF4440)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
SHD1_k127_4764110_6	1379698.RBG1_1C00001G1696	0.0007807	45.0	COG0590@1|root,COG0590@2|Bacteria,2NPM7@2323|unclassified Bacteria	2|Bacteria	FJ	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)	tadA	GO:0002097,GO:0002100,GO:0006139,GO:0006382,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016553,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360	3.5.4.1,3.5.4.33	ko:K01485,ko:K11991	ko00240,ko00330,ko01100,map00240,map00330,map01100	-	R00974,R01411,R02922,R10223	RC00074,RC00477,RC00514,RC00809	ko00000,ko00001,ko01000,ko03016	-	-	-	MafB19-deam
SHD1_k127_4764110_1	1254432.SCE1572_07235	1.955e-75	261.0	COG2021@1|root,COG2021@2|Bacteria,1PG00@1224|Proteobacteria,439DK@68525|delta/epsilon subdivisions,2X4NG@28221|Deltaproteobacteria,2YZAN@29|Myxococcales	28221|Deltaproteobacteria	E	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
SHD1_k127_4764110_3	861299.J421_1760	1.298e-19	100.0	COG0515@1|root,COG0515@2|Bacteria,1ZUFG@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
SHD1_k127_4776337_0	1284352.AOIG01000032_gene330	2.393e-258	811.0	COG0187@1|root,COG0187@2|Bacteria,1TQ0R@1239|Firmicutes,4H9Y6@91061|Bacilli,26R74@186822|Paenibacillaceae	91061|Bacilli	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005575,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
SHD1_k127_4776337_1	1379270.AUXF01000004_gene3085	9.696e-197	623.0	COG0213@1|root,COG0213@2|Bacteria,1ZTBE@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Pyrimidine nucleoside phosphorylase C-terminal domain	-	-	2.4.2.2	ko:K00756	ko00240,ko01100,map00240,map01100	-	R01570,R01876,R02296,R02484	RC00063	ko00000,ko00001,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3,PYNP_C
SHD1_k127_4776337_4	861299.J421_2718	4.763e-58	211.0	COG0457@1|root,COG0457@2|Bacteria,1ZTR4@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_4776337_3	861299.J421_2716	1.098e-66	230.0	COG0745@1|root,COG0745@2|Bacteria	861299.J421_2716|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_4776337_2	861299.J421_2715	2.793e-114	377.0	COG2199@1|root,COG3706@2|Bacteria	2|Bacteria	T	GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Response_reg
SHD1_k127_4779526_5	204669.Acid345_3285	2.339e-154	500.0	COG0531@1|root,COG0531@2|Bacteria,3Y3QM@57723|Acidobacteria,2JIFD@204432|Acidobacteriia	204432|Acidobacteriia	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
SHD1_k127_4779526_0	204669.Acid345_1918	0.0	1169.0	COG3808@1|root,COG3808@2|Bacteria,3Y34E@57723|Acidobacteria,2JJHT@204432|Acidobacteriia	204432|Acidobacteriia	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
SHD1_k127_4779526_2	861299.J421_3612	7.152e-216	682.0	COG0531@1|root,COG0531@2|Bacteria,1ZT2B@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	C-terminus of AA_permease	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
SHD1_k127_4779526_4	861299.J421_3611	1.86e-168	539.0	COG1301@1|root,COG1301@2|Bacteria,1ZT91@142182|Gemmatimonadetes	142182|Gemmatimonadetes	U	Sodium:dicarboxylate symporter family	-	-	-	ko:K11102	-	-	-	-	ko00000,ko02000	2.A.23.1.1,2.A.23.1.2	-	-	SDF
SHD1_k127_4779526_7	861299.J421_3609	1.191e-98	331.0	COG2971@1|root,COG2971@2|Bacteria,1ZT52@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	BadF/BadG/BcrA/BcrD ATPase family	-	-	2.7.1.8	ko:K18676	ko00520,ko01100,map00520,map01100	-	R01961	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	BcrAD_BadFG
SHD1_k127_4779526_1	379066.GAU_2003	1.24e-218	690.0	COG0591@1|root,COG0591@2|Bacteria,1ZTEB@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Sodium:solute symporter family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
SHD1_k127_4779526_8	861299.J421_3606	3.634e-50	181.0	COG0316@1|root,COG0316@2|Bacteria,1ZTT0@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Iron-sulphur cluster biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	Fe-S_biosyn
SHD1_k127_4779526_3	251221.35214024	9.886e-209	665.0	COG0591@1|root,COG0591@2|Bacteria,1G1JV@1117|Cyanobacteria	1117|Cyanobacteria	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	putP	-	-	-	-	-	-	-	-	-	-	-	SSF
SHD1_k127_4779526_6	379066.GAU_1999	5.111e-131	432.0	COG3876@1|root,COG3876@2|Bacteria,1ZUBN@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Protein of unknown function (DUF1343)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1343
SHD1_k127_4779526_9	1121946.AUAX01000032_gene475	2.891e-14	75.0	COG0076@1|root,COG0076@2|Bacteria,2GK3J@201174|Actinobacteria,4DDJQ@85008|Micromonosporales	201174|Actinobacteria	E	Pyridoxal-dependent decarboxylase conserved domain	-	-	1.14.13.9,4.1.1.105,4.1.1.28	ko:K00486,ko:K01593	ko00350,ko00360,ko00380,ko00901,ko00950,ko00965,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00350,map00360,map00380,map00901,map00950,map00965,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00037,M00038,M00042	R00685,R00699,R00736,R01960,R02080,R02701,R04909	RC00046,RC00299	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyridoxal_deC
SHD1_k127_4793525_9	378806.STAUR_1552	1.855e-40	154.0	COG0667@1|root,COG0667@2|Bacteria,1MVEH@1224|Proteobacteria,42MDR@68525|delta/epsilon subdivisions,2WKUR@28221|Deltaproteobacteria,2YUKZ@29|Myxococcales	28221|Deltaproteobacteria	C	Aldo/keto reductase family	-	-	1.1.1.65	ko:K05275	ko00750,ko01100,ko01120,map00750,map01100,map01120	-	R01708	RC00116	ko00000,ko00001,ko01000	-	-	-	Aldo_ket_red
SHD1_k127_4793525_3	1297865.APJD01000011_gene6559	5.257e-117	388.0	COG1181@1|root,COG1181@2|Bacteria,1N4F5@1224|Proteobacteria,2U1M9@28211|Alphaproteobacteria,3JWED@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Belongs to the D-alanine--D-alanine ligase family	-	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Methyltransf_25
SHD1_k127_4793525_5	319003.Bra1253DRAFT_03937	5.284e-81	280.0	COG4307@1|root,COG4307@2|Bacteria,1MXES@1224|Proteobacteria,2U06R@28211|Alphaproteobacteria,3JRXQ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Putative zinc-binding metallo-peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_Mx
SHD1_k127_4793525_12	861299.J421_2835	0.0001309	53.0	2EVUZ@1|root,33P8Q@2|Bacteria,1ZTJQ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_4793525_6	1120705.FG95_01994	2.201e-56	204.0	28H8Z@1|root,2Z7KS@2|Bacteria,1MW9T@1224|Proteobacteria,2U5RX@28211|Alphaproteobacteria,2K5KG@204457|Sphingomonadales	204457|Sphingomonadales	S	Yip1 domain	-	-	-	-	-	-	-	-	-	-	-	-	Yip1
SHD1_k127_4793525_1	1379270.AUXF01000002_gene1717	1.157e-201	661.0	COG5001@1|root,COG5001@2|Bacteria,1ZT12@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS
SHD1_k127_4793525_0	1192034.CAP_1907	5.423e-229	730.0	COG2382@1|root,COG2382@2|Bacteria,1R6XH@1224|Proteobacteria	1224|Proteobacteria	P	esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
SHD1_k127_4793525_7	1089550.ATTH01000001_gene164	2.136e-49	188.0	COG0637@1|root,COG0637@2|Bacteria,4PIUH@976|Bacteroidetes,1FKCU@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	Haloacid dehalogenase-like hydrolase	-	-	3.1.3.23	ko:K19270	-	-	-	-	ko00000,ko01000	-	-	-	HAD_2
SHD1_k127_4793525_4	205918.Psyr_2881	1.773e-101	336.0	COG4870@1|root,COG4870@2|Bacteria,1MV6S@1224|Proteobacteria,1S02V@1236|Gammaproteobacteria,1Z6BR@136849|Pseudomonas syringae group	1236|Gammaproteobacteria	O	Papain cysteine protease family protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C1
SHD1_k127_4793525_2	379066.GAU_3308	4.1e-125	420.0	COG2234@1|root,COG2234@2|Bacteria,1ZTDG@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
SHD1_k127_4793525_10	861299.J421_0222	1.004e-12	79.0	2BXJW@1|root,2ZMND@2|Bacteria,1ZU82@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_4793525_8	861299.J421_0175	4.27e-42	160.0	COG2204@1|root,COG2204@2|Bacteria,1ZTDN@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
SHD1_k127_482034_0	278963.ATWD01000001_gene3273	6.958e-95	315.0	COG3246@1|root,COG3246@2|Bacteria	2|Bacteria	K	L-lysine catabolic process to acetate	-	-	2.3.1.247	ko:K18013	ko00310,map00310	-	R10564	RC02728,RC03199	ko00000,ko00001,ko01000	-	-	-	BKACE
SHD1_k127_482034_1	378806.STAUR_3780	6.776e-84	289.0	COG4307@1|root,COG4307@2|Bacteria,1MXES@1224|Proteobacteria,42SJI@68525|delta/epsilon subdivisions,2WPX2@28221|Deltaproteobacteria,2YV2D@29|Myxococcales	28221|Deltaproteobacteria	S	Putative zinc-binding metallo-peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_Mx
SHD1_k127_482034_2	1254432.SCE1572_09415	9.439e-84	292.0	COG1181@1|root,COG1181@2|Bacteria,1N4F5@1224|Proteobacteria,42NYM@68525|delta/epsilon subdivisions,2WKTX@28221|Deltaproteobacteria,2YUZM@29|Myxococcales	28221|Deltaproteobacteria	F	Belongs to the D-alanine--D-alanine ligase family	-	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
SHD1_k127_4822266_1	748280.NH8B_0760	7.982e-71	254.0	COG2132@1|root,COG2132@2|Bacteria,1MV74@1224|Proteobacteria,2VK95@28216|Betaproteobacteria,2KQAW@206351|Neisseriales	206351|Neisseriales	M	Nitrite reductase, copper-dependent	nirK	-	1.3.3.5,1.7.2.1	ko:K00368,ko:K08100	ko00860,ko00910,ko01110,ko01120,map00860,map00910,map01110,map01120	M00529	R00783,R00785,R02394	RC00086,RC01983	ko00000,ko00001,ko00002,ko01000	-	-	-	Cu-oxidase,Cu-oxidase_3
SHD1_k127_4822266_2	861299.J421_5847	1.026e-36	147.0	2E3HM@1|root,30MSF@2|Bacteria,1ZV6S@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_4822266_0	1379270.AUXF01000002_gene1332	7.565e-193	616.0	COG0151@1|root,COG0151@2|Bacteria	2|Bacteria	F	phosphoribosylamine-glycine ligase activity	gshF	-	6.3.2.2	ko:K01919	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00894,R10993	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp,GARS_A,Glu_cys_ligase
SHD1_k127_4842917_3	1121272.KB903283_gene5073	8.094e-64	245.0	COG2197@1|root,COG2197@2|Bacteria,2GKXJ@201174|Actinobacteria	201174|Actinobacteria	K	PFAM regulatory protein LuxR	-	-	-	-	-	-	-	-	-	-	-	-	GerE
SHD1_k127_4842917_2	861299.J421_2130	1.264e-94	338.0	COG0515@1|root,COG0664@1|root,COG0515@2|Bacteria,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	pp2c12	-	2.7.11.1,3.1.3.16	ko:K12132,ko:K20074	-	-	-	-	ko00000,ko01000,ko01001,ko01009	-	-	-	PP2C_2,Pkinase,cNMP_binding
SHD1_k127_4842917_1	1382359.JIAL01000001_gene859	5.977e-165	537.0	COG3011@1|root,COG3011@2|Bacteria,3Y78A@57723|Acidobacteria,2JKGF@204432|Acidobacteriia	204432|Acidobacteriia	S	Lipase maturation factor	-	-	-	-	-	-	-	-	-	-	-	-	LMF1
SHD1_k127_4842917_0	861299.J421_0946	2.182e-246	769.0	COG0277@1|root,COG0277@2|Bacteria	2|Bacteria	C	FAD linked oxidase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
SHD1_k127_4850551_7	378806.STAUR_7389	9.541e-79	288.0	COG2304@1|root,COG2304@2|Bacteria,1MW8K@1224|Proteobacteria,42QVZ@68525|delta/epsilon subdivisions,2WMVN@28221|Deltaproteobacteria,2YUQR@29|Myxococcales	28221|Deltaproteobacteria	S	Vault protein inter-alpha-trypsin domain	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VIT,VWA_3
SHD1_k127_4850551_8	861299.J421_0442	1.182e-63	225.0	COG1595@1|root,COG1595@2|Bacteria,1ZTNW@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
SHD1_k127_4850551_14	1379270.AUXF01000001_gene2378	1.279e-20	105.0	COG2304@1|root,COG2304@2|Bacteria,1ZSKK@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	von Willebrand factor type A domain	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	DUF3520,VWA,vWF_A
SHD1_k127_4850551_5	861299.J421_1604	1.679e-87	300.0	COG0392@1|root,COG0392@2|Bacteria,1ZSUQ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
SHD1_k127_4850551_9	861299.J421_1786	2.191e-59	220.0	COG3386@1|root,COG3386@2|Bacteria	2|Bacteria	G	gluconolactonase activity	-	-	3.1.1.17	ko:K01053	ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02933,R03751	RC00537,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	SGL
SHD1_k127_4850551_10	926560.KE387023_gene2884	4.474e-59	209.0	COG2318@1|root,COG2318@2|Bacteria,1WMM8@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Mycothiol maleylpyruvate isomerase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
SHD1_k127_4850551_13	861299.J421_4416	2.443e-22	102.0	COG2261@1|root,COG2261@2|Bacteria,1ZV7V@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Transglycosylase associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
SHD1_k127_4850551_2	861299.J421_1669	3.832e-136	439.0	COG0623@1|root,COG0623@2|Bacteria,1ZTGW@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Enoyl-(Acyl carrier protein) reductase	-	-	1.3.1.10,1.3.1.9	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
SHD1_k127_4850551_4	631454.N177_0089	2.216e-89	308.0	COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,2TUW3@28211|Alphaproteobacteria,1JQBQ@119043|Rhodobiaceae	28211|Alphaproteobacteria	I	PLD-like domain	-	-	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2
SHD1_k127_4850551_0	1128421.JAGA01000003_gene2761	3.591e-253	793.0	COG3250@1|root,COG3250@2|Bacteria,2NPI4@2323|unclassified Bacteria	2|Bacteria	G	Glycosyl hydrolases family 2, TIM barrel domain	-	-	3.2.1.23	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	-	R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
SHD1_k127_4850551_11	861299.J421_1707	2.043e-53	194.0	COG1514@1|root,COG1514@2|Bacteria,1ZTNF@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	2'-5' RNA ligase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	2_5_RNA_ligase2
SHD1_k127_4850551_12	861299.J421_1716	9.255e-48	188.0	COG0526@1|root,COG0526@2|Bacteria,1ZTV9@142182|Gemmatimonadetes	142182|Gemmatimonadetes	CO	Thioredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
SHD1_k127_4850551_6	861299.J421_1717	1.257e-82	290.0	COG4232@1|root,COG4232@2|Bacteria,1ZSQP@142182|Gemmatimonadetes	142182|Gemmatimonadetes	CO	Cytochrome C biogenesis protein transmembrane region	-	-	1.8.1.8	ko:K04084	-	-	-	-	ko00000,ko01000,ko03110	5.A.1.1	-	-	DsbD
SHD1_k127_4850551_3	357808.RoseRS_1484	2.66e-119	396.0	COG0604@1|root,COG0604@2|Bacteria,2G6KH@200795|Chloroflexi,3763V@32061|Chloroflexia	32061|Chloroflexia	C	PFAM Alcohol dehydrogenase zinc-binding domain protein	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
SHD1_k127_4850551_1	886293.Sinac_5857	1.85e-221	706.0	COG0366@1|root,COG0366@2|Bacteria,2IYAN@203682|Planctomycetes	203682|Planctomycetes	G	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB	glgE	-	2.4.99.16	ko:K16147	ko00500,ko01100,map00500,map01100	-	R09994	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,DUF3416
SHD1_k127_4850551_15	1382359.JIAL01000001_gene2423	1.236e-17	94.0	COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria	2|Bacteria	G	trehalose biosynthetic process	treS	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016310,GO:0034637,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046835,GO:0071704,GO:0071944,GO:1901576	2.4.1.18,2.7.1.175,3.2.1.1,5.4.99.16	ko:K00700,ko:K05343,ko:K16146	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R01557,R02108,R02110,R02112,R09945,R11262	RC00002,RC00078,RC01816	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	APH,Alpha-amylase,Malt_amylase_C
SHD1_k127_4852370_2	861299.J421_3632	8.108e-85	301.0	COG2159@1|root,COG2159@2|Bacteria,1ZTHS@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_4852370_0	861299.J421_3633	2.781e-120	396.0	COG2159@1|root,COG2159@2|Bacteria,1ZSXA@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
SHD1_k127_4852370_1	861299.J421_3634	1.853e-97	327.0	COG0001@1|root,COG0001@2|Bacteria,1ZSWU@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Aminotransferase class-III	-	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
SHD1_k127_4857639_0	449447.MAE_43400	2.925e-163	522.0	COG0422@1|root,COG0422@2|Bacteria,1G2N9@1117|Cyanobacteria	1117|Cyanobacteria	H	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction	thiC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC_Rad_SAM
SHD1_k127_4857639_2	861299.J421_4451	5.595e-74	256.0	COG0590@1|root,COG0590@2|Bacteria	2|Bacteria	FJ	tRNA wobble adenosine to inosine editing	guaD	-	-	-	-	-	-	-	-	-	-	-	dCMP_cyt_deam_1
SHD1_k127_4857639_1	861299.J421_2149	1.602e-121	401.0	COG2301@1|root,COG2301@2|Bacteria	2|Bacteria	G	Belongs to the HpcH HpaI aldolase family	-	-	4.1.3.25	ko:K18292	ko00660,ko01100,map00660,map01100	-	R00237	RC00502,RC01205	ko00000,ko00001,ko01000	-	-	-	C-C_Bond_Lyase,HpcH_HpaI
SHD1_k127_4863414_6	211165.AJLN01000085_gene1580	8.88e-40	156.0	COG0664@1|root,COG0664@2|Bacteria,1G1UQ@1117|Cyanobacteria,1JIKW@1189|Stigonemataceae	1117|Cyanobacteria	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2
SHD1_k127_4863414_4	1379270.AUXF01000002_gene1600	3.737e-73	262.0	COG0515@1|root,COG0515@2|Bacteria	1379270.AUXF01000002_gene1600|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_4863414_9	1122599.AUGR01000011_gene4122	4.629e-06	49.0	COG3023@1|root,COG3420@1|root,COG3023@2|Bacteria,COG3420@2|Bacteria,1NGRY@1224|Proteobacteria,1T22S@1236|Gammaproteobacteria,1XS0U@135619|Oceanospirillales	135619|Oceanospirillales	P	Concanavalin A-like lectin/glucanases superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3
SHD1_k127_4863414_2	1504981.KO116_3166	7.273e-85	289.0	COG4106@1|root,COG4106@2|Bacteria,1Q2Y3@1224|Proteobacteria,1S2MJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_31
SHD1_k127_4863414_3	861299.J421_2454	6.521e-78	276.0	COG3240@1|root,COG3240@2|Bacteria	2|Bacteria	I	lipase activity	-	-	-	ko:K15349	ko05132,map05132	-	-	-	ko00000,ko00001	-	-	-	Lipase_GDSL,Lipase_GDSL_2
SHD1_k127_4863414_5	1089550.ATTH01000001_gene487	3.026e-70	258.0	COG2067@1|root,COG2067@2|Bacteria,4NFFF@976|Bacteroidetes,1FIPQ@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	I	Outer membrane protein transport protein (OMPP1/FadL/TodX)	-	-	-	ko:K06076	-	-	-	-	ko00000,ko02000	1.B.9	-	-	Toluene_X
SHD1_k127_4863414_0	861299.J421_3432	1.044e-267	835.0	COG3387@1|root,COG3387@2|Bacteria	2|Bacteria	G	glucan 1,4-alpha-glucosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N,F5_F8_type_C,Glyco_hydro_125
SHD1_k127_4863414_8	1379270.AUXF01000006_gene97	4.167e-13	81.0	2C3N7@1|root,33YDV@2|Bacteria,1ZTRI@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_4863414_1	379066.GAU_1864	1.736e-169	550.0	COG0497@1|root,COG0497@2|Bacteria,1ZSV4@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	May be involved in recombinational repair of damaged DNA	-	-	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	SMC_N
SHD1_k127_4863414_7	379066.GAU_1865	2.864e-17	83.0	COG0061@1|root,COG0061@2|Bacteria,1ZT32@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
SHD1_k127_48969_2	861299.J421_2365	1.207e-34	137.0	2C181@1|root,34B2S@2|Bacteria,1ZU30@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_48969_0	861299.J421_2364	3.559e-57	203.0	COG0723@1|root,COG0723@2|Bacteria,1ZU0N@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Rieske [2Fe-2S] domain	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
SHD1_k127_48969_1	861299.J421_1797	9.329e-36	143.0	COG2146@1|root,COG2146@2|Bacteria,1ZV6J@142182|Gemmatimonadetes	142182|Gemmatimonadetes	P	Rieske [2Fe-2S] domain	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
SHD1_k127_48969_3	388413.ALPR1_13919	8.507e-12	78.0	COG1629@1|root,COG4771@2|Bacteria,4NF4B@976|Bacteroidetes,47JN3@768503|Cytophagia	976|Bacteroidetes	P	TonB-dependent Receptor Plug	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,Plug,TonB_dep_Rec
SHD1_k127_4928034_3	1121468.AUBR01000093_gene750	3.98e-08	62.0	29Q0E@1|root,30AYV@2|Bacteria,1W2ZF@1239|Firmicutes	1239|Firmicutes	S	Late competence development protein ComFB	-	-	-	-	-	-	-	-	-	-	-	-	ComFB
SHD1_k127_4928034_0	861299.J421_3101	1.827e-208	669.0	COG0621@1|root,COG0621@2|Bacteria,1ZT0Z@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
SHD1_k127_4928034_1	861299.J421_3098	1.797e-167	534.0	COG0642@1|root,COG2205@2|Bacteria	861299.J421_3098|-	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_4928034_2	861299.J421_3097	3.108e-46	176.0	2EYUI@1|root,33S1Q@2|Bacteria,1ZTHR@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_4931025_2	448385.sce8955	9.454e-44	176.0	COG1835@1|root,COG1835@2|Bacteria,1MV2W@1224|Proteobacteria,42R7N@68525|delta/epsilon subdivisions,2WSTT@28221|Deltaproteobacteria,2Z27Z@29|Myxococcales	28221|Deltaproteobacteria	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
SHD1_k127_4931025_1	861299.J421_2368	8.45e-79	278.0	2EXE5@1|root,33QQP@2|Bacteria,1ZTI3@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_4931025_4	861299.J421_4113	0.0005876	47.0	COG0745@1|root,COG0745@2|Bacteria	861299.J421_4113|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_4931025_3	380703.AHA_3000	3.431e-05	51.0	COG1396@1|root,COG1917@1|root,COG1396@2|Bacteria,COG1917@2|Bacteria,1RCYA@1224|Proteobacteria,1S4B9@1236|Gammaproteobacteria,1Y5N8@135624|Aeromonadales	135624|Aeromonadales	K	Helix-turn-helix XRE-family like proteins	-	-	-	ko:K14056	-	-	-	-	ko00000,ko03000	-	-	-	Cupin_2,HTH_31
SHD1_k127_4931025_0	1254432.SCE1572_34120	2.258e-82	302.0	COG2234@1|root,COG2234@2|Bacteria,1R56X@1224|Proteobacteria,43823@68525|delta/epsilon subdivisions,2X3C5@28221|Deltaproteobacteria,2YVD0@29|Myxococcales	28221|Deltaproteobacteria	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
SHD1_k127_4945410_1	880074.BARVI_08660	1.132e-58	217.0	COG3392@1|root,COG3392@2|Bacteria,4NJNW@976|Bacteroidetes,2FRYH@200643|Bacteroidia,22YFJ@171551|Porphyromonadaceae	976|Bacteroidetes	L	DNA methyltransferase	-	-	2.1.1.72	ko:K07318	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	MethyltransfD12
SHD1_k127_4945410_0	379066.GAU_0474	7.307e-96	317.0	COG1595@1|root,COG1595@2|Bacteria,1ZSWF@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
SHD1_k127_4945410_2	861299.J421_2381	1.308e-20	96.0	2900U@1|root,2ZMR2@2|Bacteria,1ZU6I@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_4954230_1	1379270.AUXF01000002_gene1586	7.821e-80	284.0	COG0515@1|root,COG0515@2|Bacteria	1379270.AUXF01000002_gene1586|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_4954230_2	710111.FraQA3DRAFT_1591	2.195e-49	183.0	COG2258@1|root,COG2258@2|Bacteria,2GMCN@201174|Actinobacteria,4ESV0@85013|Frankiales	201174|Actinobacteria	S	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	3-alpha,MOSC
SHD1_k127_4954230_0	861299.J421_5976	2.844e-110	369.0	COG1533@1|root,COG1533@2|Bacteria,1ZUFM@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
SHD1_k127_4954230_3	1437882.AZRU01000044_gene6604	5.331e-37	143.0	COG2513@1|root,COG2513@2|Bacteria,1R3SD@1224|Proteobacteria,1RZCP@1236|Gammaproteobacteria,1YEGR@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	G	Phosphoenolpyruvate phosphomutase	-	-	-	-	-	-	-	-	-	-	-	-	PEP_mutase
SHD1_k127_4955083_0	861299.J421_3561	0.0	1095.0	COG0556@1|root,COG0556@2|Bacteria,1ZSQS@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
SHD1_k127_4955083_1	861299.J421_3560	2.137e-52	192.0	COG0802@1|root,COG0802@2|Bacteria,1ZTY0@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Threonylcarbamoyl adenosine biosynthesis protein TsaE	-	-	2.7.1.221	ko:K06925,ko:K07102	ko00520,ko01100,map00520,map01100	-	R08968,R11024	RC00002,RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	TsaE
SHD1_k127_4955083_2	861299.J421_3559	1.095e-43	169.0	COG1214@1|root,COG1214@2|Bacteria,1ZU16@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	Glycoprotease family	-	-	-	ko:K14742	-	-	-	-	ko00000,ko03016	-	-	-	Peptidase_M22
SHD1_k127_4955083_3	861299.J421_3558	4.531e-38	149.0	COG0454@1|root,COG0456@2|Bacteria,1ZU09@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	This enzyme acetylates the N-terminal alanine of ribosomal protein S18	-	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
SHD1_k127_4975820_0	861299.J421_3008	2.113e-137	453.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1ZTAT@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
SHD1_k127_4975820_1	861299.J421_3009	4.751e-78	270.0	COG0611@1|root,COG0611@2|Bacteria,1ZTIU@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
SHD1_k127_4978930_0	861299.J421_1643	0.0	1255.0	COG4447@1|root,COG4447@2|Bacteria,1ZT1T@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Sortilin, neurotensin receptor 3,	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
SHD1_k127_4978930_3	379066.GAU_2000	4.951e-70	256.0	COG1680@1|root,COG1680@2|Bacteria,1ZT58@142182|Gemmatimonadetes	142182|Gemmatimonadetes	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
SHD1_k127_4978930_2	228410.NE2508	1.195e-79	278.0	COG3193@1|root,COG3193@2|Bacteria,1R215@1224|Proteobacteria	1224|Proteobacteria	S	protein possibly involved in utilization of glycolate and propanediol	-	-	-	-	-	-	-	-	-	-	-	-	Haem_degrading
SHD1_k127_4978930_4	765420.OSCT_0546	6.772e-36	153.0	COG0589@1|root,COG0589@2|Bacteria,2G8FB@200795|Chloroflexi,377FW@32061|Chloroflexia	32061|Chloroflexia	T	Belongs to the universal stress protein A family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
SHD1_k127_4978930_1	767817.Desgi_0402	4.698e-187	619.0	COG0474@1|root,COG0474@2|Bacteria,1TPF5@1239|Firmicutes,247JN@186801|Clostridia,25ZY7@186807|Peptococcaceae	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	pacL	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
SHD1_k127_4978930_5	555500.I215_06187	0.0002362	49.0	COG0628@1|root,COG0628@2|Bacteria,4NIB3@976|Bacteroidetes,1HYV6@117743|Flavobacteriia	976|Bacteroidetes	S	permease	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
SHD1_k127_4979008_1	1297742.A176_05941	1.572e-164	529.0	COG0160@1|root,COG0160@2|Bacteria,1MWY6@1224|Proteobacteria,42MB7@68525|delta/epsilon subdivisions,2WJVU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.19	ko:K00823	ko00250,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
SHD1_k127_4979008_0	378806.STAUR_1586	2.848e-167	542.0	COG1012@1|root,COG1012@2|Bacteria,1QWN5@1224|Proteobacteria,43BT3@68525|delta/epsilon subdivisions,2X73T@28221|Deltaproteobacteria,2YYMR@29|Myxococcales	28221|Deltaproteobacteria	C	Aldehyde dehydrogenase family	-	-	1.2.1.88	ko:K00294	ko00250,ko00330,ko01100,map00250,map00330,map01100	-	R00245,R00707,R00708,R04444,R04445,R05051	RC00080,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000	-	-	-	Aldedh
SHD1_k127_4979008_2	1242864.D187_005843	1.037e-120	401.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,42MFC@68525|delta/epsilon subdivisions,2WINR@28221|Deltaproteobacteria,2YX29@29|Myxococcales	28221|Deltaproteobacteria	H	Aminotransferase class-III	-	-	2.6.1.55,2.6.1.77	ko:K03851,ko:K15372	ko00410,ko00430,ko01100,map00410,map00430,map01100	-	R00908,R01684,R05652	RC00006,RC00008,RC00062	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_3
SHD1_k127_4979155_3	861299.J421_3439	5.542e-90	303.0	COG1570@1|root,COG1570@2|Bacteria,1ZT8T@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
SHD1_k127_4979155_5	330214.NIDE3720	1.286e-06	60.0	COG1722@1|root,COG1722@2|Bacteria	2|Bacteria	L	exodeoxyribonuclease VII activity	xseB	-	3.1.11.6	ko:K03602	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_S
SHD1_k127_4979155_2	861299.J421_3437	7.783e-100	337.0	COG0142@1|root,COG0142@2|Bacteria,1ZSR3@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Polyprenyl synthetase	-	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00366	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
SHD1_k127_4979155_0	379066.GAU_1866	5.494e-301	934.0	COG1154@1|root,COG1154@2|Bacteria,1ZSP2@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
SHD1_k127_4979155_1	379066.GAU_1865	3.71e-100	338.0	COG0061@1|root,COG0061@2|Bacteria,1ZT32@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
SHD1_k127_4979155_4	861299.J421_3434	1.313e-33	132.0	COG0497@1|root,COG0497@2|Bacteria,1ZSV4@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	May be involved in recombinational repair of damaged DNA	-	-	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	SMC_N
SHD1_k127_4980336_1	861299.J421_4135	2.782e-112	375.0	COG0515@1|root,COG0515@2|Bacteria,1ZUAC@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
SHD1_k127_4980336_0	1123248.KB893317_gene4264	1.339e-130	423.0	COG1228@1|root,COG1228@2|Bacteria,4NKV0@976|Bacteroidetes	976|Bacteroidetes	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
SHD1_k127_4985347_0	1410620.SHLA_19c000230	3.607e-114	385.0	COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,2TRUB@28211|Alphaproteobacteria,4B7BD@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase	dnaE2	GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496	2.7.7.7	ko:K02337,ko:K14162	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
SHD1_k127_4985347_1	1118054.CAGW01000015_gene4585	1.281e-48	178.0	COG2008@1|root,COG2008@2|Bacteria,1TPZI@1239|Firmicutes,4HA1R@91061|Bacilli,26UBS@186822|Paenibacillaceae	91061|Bacilli	E	Threonine aldolase	ltaE	-	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	-	R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
SHD1_k127_5001237_0	1379270.AUXF01000003_gene3807	2.476e-186	589.0	COG1166@1|root,COG1166@2|Bacteria,1ZST1@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Catalyzes the biosynthesis of agmatine from arginine	speA	-	4.1.1.19	ko:K01585	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N
SHD1_k127_5001237_1	483219.LILAB_02305	1.895e-68	237.0	COG0259@1|root,COG0259@2|Bacteria,1NZUU@1224|Proteobacteria,42SKB@68525|delta/epsilon subdivisions,2WQ2K@28221|Deltaproteobacteria,2YV8W@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)	pdxH	-	1.4.3.5	ko:K00275	ko00750,ko01100,ko01120,map00750,map01100,map01120	M00124	R00277,R00278,R01710,R01711	RC00048,RC00116	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_phzG_C,Putative_PNPOx
SHD1_k127_501330_3	861299.J421_1864	2.336e-137	458.0	COG0038@1|root,COG0038@2|Bacteria	2|Bacteria	P	chloride channel	clcA	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	-	CBS,Voltage_CLC
SHD1_k127_501330_4	379066.GAU_2851	3.607e-99	332.0	COG1162@1|root,COG1162@2|Bacteria,1ZSSQ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit	rsgA	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	RsgA_GTPase
SHD1_k127_501330_5	861299.J421_4532	5.805e-34	134.0	2FDUV@1|root,345VG@2|Bacteria,1ZTXA@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_501330_2	861299.J421_4533	2.015e-141	455.0	COG0506@1|root,COG0506@2|Bacteria,1ZT6A@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Proline dehydrogenase	-	-	-	ko:K00318	ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130	-	R10507	RC00083	ko00000,ko00001,ko01000	-	-	-	Pro_dh
SHD1_k127_501330_1	861299.J421_4536	1.59e-159	524.0	COG2866@1|root,COG2866@2|Bacteria,1ZT9V@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Zn_pept	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
SHD1_k127_501330_0	504472.Slin_6185	1.464e-176	579.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,4NETS@976|Bacteroidetes,47KF8@768503|Cytophagia	976|Bacteroidetes	EU	Dipeptidyl peptidase IV (DPP IV) N-terminal region	dpp	-	3.4.14.5	ko:K01278	ko04974,map04974	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	DPPIV_N,Peptidase_S9
SHD1_k127_5017018_1	1379270.AUXF01000006_gene26	5.847e-124	434.0	COG0457@1|root,COG0457@2|Bacteria,1ZU0J@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_8
SHD1_k127_5017018_0	379066.GAU_1932	1.71e-124	409.0	COG0142@1|root,COG0142@2|Bacteria,1ZT7D@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Polyprenyl synthetase	-	-	2.5.1.90	ko:K02523	ko00900,ko01110,map00900,map01110	-	R09248	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
SHD1_k127_5017018_2	1379270.AUXF01000006_gene28	7.957e-38	144.0	2FH8C@1|root,3492Q@2|Bacteria,1ZTXE@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Domain of unknown function (DUF4321)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4321
SHD1_k127_5017018_3	379066.GAU_1930	1.113e-14	78.0	COG1826@1|root,COG1826@2|Bacteria,1ZU4N@142182|Gemmatimonadetes	142182|Gemmatimonadetes	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	tatA	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
SHD1_k127_5026382_1	861299.J421_0942	2.581e-87	300.0	COG0003@1|root,COG0003@2|Bacteria,1ZVAB@142182|Gemmatimonadetes	142182|Gemmatimonadetes	P	Anion-transporting ATPase	-	-	3.6.3.16	ko:K01551	-	-	-	-	ko00000,ko01000,ko02000	3.A.19.1,3.A.21.1,3.A.4.1	-	-	ArsA_ATPase
SHD1_k127_5026382_2	861299.J421_0941	4.888e-52	200.0	2C8AD@1|root,32RKP@2|Bacteria	2|Bacteria	S	Gas vesicle	-	-	-	-	-	-	-	-	-	-	-	-	GvpL_GvpF
SHD1_k127_5026382_7	994479.GL877881_gene6342	5.662e-07	60.0	2DM5J@1|root,31T6B@2|Bacteria,2GMP8@201174|Actinobacteria,4E7CD@85010|Pseudonocardiales	201174|Actinobacteria	S	Gas vesicle synthesis protein GvpL/GvpF	gvpL2	-	-	-	-	-	-	-	-	-	-	-	GvpL_GvpF
SHD1_k127_5026382_5	861299.J421_0938	1.519e-35	144.0	arCOG06390@1|root,330IR@2|Bacteria	2|Bacteria	S	Gas vesicle protein K	gvpK	-	-	-	-	-	-	-	-	-	-	-	Gas_vesicle,GvpK
SHD1_k127_5026382_4	861299.J421_0937	2.559e-38	145.0	2E5BC@1|root,3303G@2|Bacteria	2|Bacteria	S	Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth	gvpJ	-	-	-	-	-	-	-	-	-	-	-	Gas_vesicle
SHD1_k127_5026382_3	861299.J421_0936	4.098e-39	147.0	arCOG03092@1|root,32YMQ@2|Bacteria	2|Bacteria	S	Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth. GvpA type proteins form the essential core of the structure	gvpA	-	-	-	-	-	-	-	-	-	-	-	Gas_vesicle
SHD1_k127_5026382_0	861299.J421_0935	1.452e-219	702.0	COG5002@1|root,COG5002@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	-	-	2.7.13.3	ko:K03407,ko:K07678	ko02020,ko02025,ko02026,ko02030,ko05111,map02020,map02025,map02026,map02030,map05111	M00475,M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	GAF_2,HAMP,HATPase_c,HisKA,Hpt,PAS,PAS_4,PAS_8,PAS_9,Response_reg
SHD1_k127_5038093_0	357808.RoseRS_3430	1.19e-272	863.0	COG1201@1|root,COG1201@2|Bacteria	2|Bacteria	L	RNA secondary structure unwinding	lhr	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
SHD1_k127_5038093_1	234267.Acid_3563	7.118e-216	691.0	COG1793@1|root,COG1793@2|Bacteria,3Y3AP@57723|Acidobacteria	57723|Acidobacteria	L	DNA ligase	-	-	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N
SHD1_k127_5038093_3	1379270.AUXF01000001_gene2003	2.384e-146	473.0	COG1236@1|root,COG1236@2|Bacteria,1ZTZ5@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Exonuclease of the beta-lactamase fold involved in RNA processing	-	-	-	ko:K07577	-	-	-	-	ko00000	-	-	-	-
SHD1_k127_5038093_6	367299.JOEE01000001_gene2125	2.926e-19	102.0	COG0642@1|root,COG2770@1|root,COG2205@2|Bacteria,COG2770@2|Bacteria,2I2QY@201174|Actinobacteria,4FF56@85021|Intrasporangiaceae	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4173,HAMP,HATPase_c,HisKA
SHD1_k127_5038093_5	1121957.ATVL01000009_gene1280	1.516e-141	479.0	COG1368@1|root,COG1368@2|Bacteria,4NFI9@976|Bacteroidetes,47K4G@768503|Cytophagia	976|Bacteroidetes	M	COGs COG1368 Phosphoglycerol transferase and related protein alkaline phosphatase superfamily	ltaS2	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
SHD1_k127_5038093_2	861299.J421_0912	7.932e-191	621.0	COG3664@1|root,COG3664@2|Bacteria	2|Bacteria	G	PFAM glycoside hydrolase family 39	-	-	-	-	-	-	-	-	-	-	-	-	F5_F8_type_C
SHD1_k127_5038093_4	1379270.AUXF01000001_gene2863	1.103e-145	491.0	COG4772@1|root,COG4772@2|Bacteria,1ZT8H@142182|Gemmatimonadetes	142182|Gemmatimonadetes	P	TonB dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
SHD1_k127_5038093_7	1382359.JIAL01000001_gene2953	8.532e-11	63.0	COG4272@1|root,COG4272@2|Bacteria,3Y5P5@57723|Acidobacteria,2JJWD@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein of unknown function (DUF1634)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1634
SHD1_k127_5053076_1	1121403.AUCV01000046_gene1089	4.461e-06	59.0	COG0664@1|root,COG1413@1|root,COG0664@2|Bacteria,COG1413@2|Bacteria,1RJYT@1224|Proteobacteria,42T0W@68525|delta/epsilon subdivisions,2WP8U@28221|Deltaproteobacteria,2MK7T@213118|Desulfobacterales	28221|Deltaproteobacteria	T	cyclic nucleotide-binding	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HEAT_2,PilZ,cNMP_binding
SHD1_k127_5053076_0	1379270.AUXF01000001_gene2066	1.832e-68	249.0	COG2206@1|root,COG2206@2|Bacteria	2|Bacteria	T	PFAM metal-dependent phosphohydrolase, HD sub domain	-	-	-	-	-	-	-	-	-	-	-	-	HD
SHD1_k127_5081851_3	379066.GAU_1295	1.111e-67	234.0	COG0112@1|root,COG0112@2|Bacteria,1ZT5K@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
SHD1_k127_5081851_0	861299.J421_3004	1.568e-189	597.0	COG0334@1|root,COG0334@2|Bacteria,1ZTBQ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase	-	-	1.4.1.9	ko:K00263	ko00280,ko00290,ko01100,ko01110,ko01130,map00280,map00290,map01100,map01110,map01130	-	R01088,R01434,R02196	RC00006,RC00036	ko00000,ko00001,ko01000	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
SHD1_k127_5081851_1	861299.J421_3003	1.332e-177	563.0	COG1960@1|root,COG1960@2|Bacteria,1ZSRC@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
SHD1_k127_5081851_2	1379270.AUXF01000005_gene596	2.175e-128	422.0	COG1250@1|root,COG1250@2|Bacteria,1ZSRN@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
SHD1_k127_5081851_4	861299.J421_3001	3.833e-53	203.0	COG1266@1|root,COG1266@2|Bacteria,1ZTXV@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
SHD1_k127_5081851_5	1302863.I872_06975	2.553e-09	63.0	COG1268@1|root,COG1268@2|Bacteria,1VA1G@1239|Firmicutes,4HNE8@91061|Bacilli	91061|Bacilli	S	biotin synthase	bioY	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03523	ko02010,map02010	M00581,M00582	-	-	ko00000,ko00001,ko00002,ko02000	2.A.88.1,2.A.88.2	-	-	BioY
SHD1_k127_5096647_4	1123277.KB893185_gene2990	8.316e-39	151.0	COG1878@1|root,COG1878@2|Bacteria,4NHMW@976|Bacteroidetes,47MGZ@768503|Cytophagia	976|Bacteroidetes	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
SHD1_k127_5096647_1	1502851.FG93_02679	5.831e-107	353.0	COG3485@1|root,COG3485@2|Bacteria,1MUYX@1224|Proteobacteria,2TU2C@28211|Alphaproteobacteria,3JT90@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Protocatechuate 3,4-dioxygenase beta subunit N terminal	pcaH	-	1.13.11.3	ko:K00449	ko00362,ko00624,ko01100,ko01120,ko01220,map00362,map00624,map01100,map01120,map01220	-	R01631,R03549	RC00388,RC00953	br01602,ko00000,ko00001,ko01000	-	-	-	Dioxygenase_C,PCDO_beta_N
SHD1_k127_5096647_2	1122604.JONR01000001_gene1760	1.153e-53	196.0	COG3485@1|root,COG3485@2|Bacteria,1MV3B@1224|Proteobacteria,1S8B3@1236|Gammaproteobacteria,1X7D9@135614|Xanthomonadales	135614|Xanthomonadales	Q	protocatechuate 3,4-dioxygenase	pcaG	-	1.13.11.3	ko:K00448	ko00362,ko00624,ko01100,ko01120,ko01220,map00362,map00624,map01100,map01120,map01220	-	R01631,R03549	RC00388,RC00953	br01602,ko00000,ko00001,ko01000	-	-	-	Dioxygenase_C
SHD1_k127_5096647_0	748280.NH8B_2497	3.387e-119	397.0	COG0015@1|root,COG0015@2|Bacteria,1MXNN@1224|Proteobacteria,2VID3@28216|Betaproteobacteria	28216|Betaproteobacteria	F	3-carboxy-cis,cis-muconate cycloisomerase	pcaB	-	5.5.1.2	ko:K01857	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R03307	RC00902	ko00000,ko00001,ko01000	-	-	-	ADSL_C,Lyase_1
SHD1_k127_5096647_3	1194165.CAJF01000017_gene3534	1.897e-42	159.0	COG0599@1|root,COG0599@2|Bacteria,2GITB@201174|Actinobacteria,4FPZ9@85023|Microbacteriaceae	201174|Actinobacteria	S	Carboxymuconolactone decarboxylase family	pcaC	-	3.1.1.24,4.1.1.44	ko:K01607,ko:K14727	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00568	R02991,R03470	RC00825,RC00938	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1,Abhydrolase_4,CMD
SHD1_k127_5096647_5	263358.VAB18032_19700	1.196e-36	139.0	COG0654@1|root,COG0654@2|Bacteria,2GM48@201174|Actinobacteria,4DA82@85008|Micromonosporales	201174|Actinobacteria	CH	FAD binding domain	pobA	-	1.14.13.2	ko:K00481	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R01298	RC00046	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3
SHD1_k127_5102454_0	861299.J421_3780	1.219e-232	728.0	COG0178@1|root,COG0178@2|Bacteria,1ZT1W@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	-	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
SHD1_k127_5102454_2	706587.Desti_2068	2.656e-20	93.0	COG2261@1|root,COG2261@2|Bacteria	2|Bacteria	S	Transglycosylase associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
SHD1_k127_5102454_3	476272.RUMHYD_01584	6.594e-18	96.0	COG1131@1|root,COG1131@2|Bacteria,1V0ED@1239|Firmicutes,24BB5@186801|Clostridia	186801|Clostridia	V	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane,ABC_tran,FHA
SHD1_k127_5102454_1	861299.J421_3777	9.174e-103	339.0	COG0631@1|root,COG0631@2|Bacteria,1ZSYG@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	Serine/threonine phosphatases, family 2C, catalytic domain	-	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C_2
SHD1_k127_5128943_1	886293.Sinac_5836	1.468e-184	598.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,2IXK8@203682|Planctomycetes	203682|Planctomycetes	E	Prolyl oligopeptidase family	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
SHD1_k127_5128943_3	861299.J421_2637	4.764e-19	95.0	2C30C@1|root,2ZV1M@2|Bacteria,1ZV6Z@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_5128943_5	404589.Anae109_0136	0.0001007	52.0	COG1716@1|root,COG2199@1|root,COG1716@2|Bacteria,COG3706@2|Bacteria,1MVME@1224|Proteobacteria,43AKG@68525|delta/epsilon subdivisions,2X60I@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Forkhead associated domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA,GGDEF
SHD1_k127_5128943_0	1340493.JNIF01000004_gene652	1.742e-245	773.0	COG2274@1|root,COG2274@2|Bacteria	2|Bacteria	V	protein secretion by the type I secretion system	-	-	-	ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106	-	-	ABC_membrane,ABC_tran
SHD1_k127_5128943_2	861299.J421_0909	6.424e-50	184.0	COG2940@1|root,COG2940@2|Bacteria,1ZTR3@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain	-	-	-	ko:K07117	-	-	-	-	ko00000	-	-	-	SET
SHD1_k127_5137855_1	1266925.JHVX01000001_gene2459	6.427e-209	668.0	COG3459@1|root,COG3459@2|Bacteria,1MVNX@1224|Proteobacteria,2VKDG@28216|Betaproteobacteria,371PE@32003|Nitrosomonadales	28216|Betaproteobacteria	G	Glycosyl hydrolase 36 superfamily, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_36,Glyco_transf_36,Glycoamylase
SHD1_k127_5137855_2	1163409.UUA_16123	1.471e-192	610.0	COG2723@1|root,COG2723@2|Bacteria,1MWG6@1224|Proteobacteria,1RMM2@1236|Gammaproteobacteria,1X3QG@135614|Xanthomonadales	135614|Xanthomonadales	G	COG2723 Beta-glucosidase 6-phospho-beta-glucosidase beta- galactosidase	-	-	3.2.1.21	ko:K05350	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_1
SHD1_k127_5137855_3	1205753.A989_16158	3.921e-119	394.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,1RM9E@1236|Gammaproteobacteria,1X4C8@135614|Xanthomonadales	135614|Xanthomonadales	P	Belongs to the ABC transporter superfamily	ugpC	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE_2
SHD1_k127_5137855_4	518766.Rmar_1565	2.332e-62	218.0	COG1622@1|root,COG1622@2|Bacteria,4P5ZE@976|Bacteroidetes,1FJK0@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	C	Cytochrome C oxidase subunit II, periplasmic domain	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2
SHD1_k127_5137855_0	518766.Rmar_1564	1.652e-244	771.0	COG0843@1|root,COG0843@2|Bacteria,4P06K@976|Bacteroidetes,1FJ2A@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	C	cytochrome c oxidase subunit I	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
SHD1_k127_514452_0	1183438.GKIL_2082	2.573e-208	664.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1GDGA@1117|Cyanobacteria	1117|Cyanobacteria	EU	Prolyl oligopeptidase family	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
SHD1_k127_5150768_3	1303518.CCALI_01218	3.359e-09	66.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,GtrA,PMT_2
SHD1_k127_5150768_1	456442.Mboo_1832	3.334e-61	233.0	COG0677@1|root,arCOG00252@2157|Archaea,2Y2A7@28890|Euryarchaeota,2NA83@224756|Methanomicrobia	224756|Methanomicrobia	M	PFAM UDP-glucose GDP-mannose dehydrogenase	-	-	1.1.1.336	ko:K02472	ko00520,ko05111,map00520,map05111	-	R03317	RC00291	ko00000,ko00001,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
SHD1_k127_5150768_0	1200792.AKYF01000027_gene419	3.264e-196	633.0	COG0367@1|root,COG0367@2|Bacteria,1TRPB@1239|Firmicutes,4HAIP@91061|Bacilli,26QDS@186822|Paenibacillaceae	91061|Bacilli	E	Asparagine synthase	asnH	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
SHD1_k127_5150768_2	143224.JQMD01000002_gene3423	2.008e-57	206.0	COG0726@1|root,COG0726@2|Bacteria	2|Bacteria	G	polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
SHD1_k127_5158302_1	379066.GAU_3018	1.983e-111	366.0	COG0349@1|root,COG0349@2|Bacteria,1ZSPS@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	3'-5' exonuclease	-	-	3.1.13.5	ko:K03684	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DNA_pol_A_exo1,HRDC
SHD1_k127_5158302_0	861299.J421_6166	1.775e-120	400.0	COG0628@1|root,COG0628@2|Bacteria,1ZSY6@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
SHD1_k127_5162058_0	379066.GAU_1671	3.993e-158	505.0	COG2896@1|root,COG2896@2|Bacteria,1ZSMN@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Mob_synth_C,Radical_SAM
SHD1_k127_5162058_1	379066.GAU_1672	6.21e-34	139.0	COG0314@1|root,COG0314@2|Bacteria,1ZU08@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	MoaE protein	-	-	2.8.1.12	ko:K03635	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoaE
SHD1_k127_5162058_2	861299.J421_3304	6.96e-17	82.0	COG1977@1|root,COG1977@2|Bacteria,1ZU69@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	ThiS family	-	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
SHD1_k127_518858_0	861299.J421_2756	3.714e-142	459.0	COG3367@1|root,COG3367@2|Bacteria,1ZUM9@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Domain of unknown function (DUF1611_N) Rossmann-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF1611,DUF1611_N
SHD1_k127_518858_1	861299.J421_2755	7.893e-28	116.0	COG0628@1|root,COG0628@2|Bacteria	2|Bacteria	D	permease	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
SHD1_k127_5191879_0	861299.J421_6091	8.388e-208	664.0	COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,1ZSS1@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	Tricorn protease homolog	-	-	-	ko:K08676	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ
SHD1_k127_5191879_2	861299.J421_6092	2.596e-160	522.0	COG1680@1|root,COG1680@2|Bacteria,1ZUKR@142182|Gemmatimonadetes	142182|Gemmatimonadetes	V	Domain of unknown function (DUF3471)	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,DUF3471
SHD1_k127_5191879_1	379066.GAU_2322	2.061e-174	559.0	COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,1ZSS1@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	Tricorn protease homolog	-	-	-	ko:K08676	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ
SHD1_k127_5192285_0	1379270.AUXF01000005_gene582	3.353e-243	759.0	COG0697@1|root,COG2976@1|root,COG0697@2|Bacteria,COG2976@2|Bacteria,1ZT9A@142182|Gemmatimonadetes	142182|Gemmatimonadetes	EG	Protein of unknown function (DUF2723)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2723
SHD1_k127_520344_9	379066.GAU_1541	2.634e-07	53.0	COG2018@1|root,COG2018@2|Bacteria,1ZU1J@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Roadblock/LC7 domain	-	-	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
SHD1_k127_520344_5	861299.J421_3172	3.149e-52	189.0	COG0745@1|root,COG0745@2|Bacteria,1ZU0B@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
SHD1_k127_520344_1	1379270.AUXF01000005_gene805	6.577e-125	415.0	COG0836@1|root,COG0836@2|Bacteria,1ZT5Z@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	Nucleotidyl transferase	-	-	2.7.7.13	ko:K00971	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
SHD1_k127_520344_2	861299.J421_3170	1.889e-124	414.0	COG1208@1|root,COG1208@2|Bacteria,1ZSVN@142182|Gemmatimonadetes	142182|Gemmatimonadetes	JM	Sugar nucleotidyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_4
SHD1_k127_520344_3	861299.J421_3169	3.656e-74	258.0	COG1235@1|root,COG1235@2|Bacteria,1ZTN8@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
SHD1_k127_520344_8	1353529.M899_0425	3.819e-09	68.0	COG0741@1|root,COG0741@2|Bacteria	2|Bacteria	M	lytic transglycosylase activity	-	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	SLT
SHD1_k127_520344_0	861299.J421_3164	2.682e-298	921.0	COG0459@1|root,COG0459@2|Bacteria,1ZTC5@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	-	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
SHD1_k127_520344_6	1379270.AUXF01000005_gene789	1.657e-43	161.0	COG0234@1|root,COG0234@2|Bacteria,1ZTZB@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	-	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
SHD1_k127_520344_4	903818.KI912268_gene1569	1.292e-68	247.0	COG0382@1|root,COG0382@2|Bacteria	2|Bacteria	H	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate	ubiA	-	2.5.1.133,2.5.1.62	ko:K04040,ko:K20616	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R06284,R09067,R11514,R11517	RC00020	ko00000,ko00001,ko01000,ko01006	-	-	-	UbiA
SHD1_k127_520344_7	1033743.CAES01000109_gene3360	5.528e-12	68.0	COG1521@1|root,COG1521@2|Bacteria,1TR0X@1239|Firmicutes,4H9QA@91061|Bacilli,26RR9@186822|Paenibacillaceae	91061|Bacilli	H	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis	coaX	-	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Pan_kinase
SHD1_k127_5210709_0	1173028.ANKO01000202_gene3448	3.622e-181	579.0	COG0855@1|root,COG0855@2|Bacteria,1G1WA@1117|Cyanobacteria,1H9DA@1150|Oscillatoriales	1117|Cyanobacteria	P	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
SHD1_k127_5210709_1	1379270.AUXF01000003_gene3561	1.221e-126	415.0	COG0248@1|root,COG2206@1|root,COG0248@2|Bacteria,COG2206@2|Bacteria,1ZTH0@142182|Gemmatimonadetes	142182|Gemmatimonadetes	FPT	Ppx/GppA phosphatase family	-	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	HD,Ppx-GppA
SHD1_k127_5213049_3	861299.J421_1011	1.164e-142	467.0	COG3590@1|root,COG3590@2|Bacteria	2|Bacteria	O	peptidase	pepO	-	3.4.24.11,3.4.24.71	ko:K01389,ko:K01415,ko:K07386	ko04614,ko04640,ko04974,ko05010,map04614,map04640,map04974,map05010	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	Peptidase_M13,Peptidase_M13_N
SHD1_k127_5213049_10	1121943.KB899997_gene1731	2.65e-06	59.0	2EERX@1|root,338JK@2|Bacteria,1NEZQ@1224|Proteobacteria	1224|Proteobacteria	S	Protein of unknown function (DUF3618)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3618
SHD1_k127_5213049_1	861299.J421_5759	3.033e-163	540.0	COG0515@1|root,COG5616@1|root,COG0515@2|Bacteria,COG5616@2|Bacteria,1ZUKV@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
SHD1_k127_5213049_0	861299.J421_2964	1.613e-175	574.0	COG0012@1|root,COG0012@2|Bacteria,1ZSPQ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
SHD1_k127_5213049_4	861299.J421_2965	2.108e-77	263.0	COG0193@1|root,COG0193@2|Bacteria,1ZTKT@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	-	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
SHD1_k127_5213049_5	1379270.AUXF01000005_gene525	1.728e-68	240.0	COG1825@1|root,COG1825@2|Bacteria,1ZTHZ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	-	-	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
SHD1_k127_5213049_2	1379270.AUXF01000005_gene526	4.316e-161	512.0	COG0462@1|root,COG0462@2|Bacteria,1ZT7Q@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
SHD1_k127_5213049_6	861299.J421_2968	1.59e-62	231.0	COG1947@1|root,COG1947@2|Bacteria,1ZTM9@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	ispE	-	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_N
SHD1_k127_5213049_7	379066.GAU_1245	1.255e-39	151.0	COG0392@1|root,COG0392@2|Bacteria,1ZT5W@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
SHD1_k127_5223414_0	1379270.AUXF01000003_gene3614	4.513e-61	232.0	COG1629@1|root,COG4771@2|Bacteria,1ZUBX@142182|Gemmatimonadetes	142182|Gemmatimonadetes	P	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,Plug,TonB_dep_Rec
SHD1_k127_5223414_1	1379270.AUXF01000001_gene2586	6.261e-43	171.0	COG3712@1|root,COG3712@2|Bacteria,1ZTPC@142182|Gemmatimonadetes	142182|Gemmatimonadetes	PT	Domain of unknown function (DUF4974)	-	-	-	ko:K07165	-	-	-	-	ko00000	-	-	-	DUF4974,FecR
SHD1_k127_5223414_2	861299.J421_2384	9.136e-32	132.0	COG1595@1|root,COG1595@2|Bacteria,1ZUWI@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	ECF sigma factor	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
SHD1_k127_5223414_3	379066.GAU_0792	3.861e-05	55.0	COG0457@1|root,COG0457@2|Bacteria,1ZTR4@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_5227179_3	661478.OP10G_0240	6.126e-82	301.0	COG1626@1|root,COG1626@2|Bacteria	2|Bacteria	G	alpha,alpha-trehalase activity	ygjK	GO:0003674,GO:0003824,GO:0004553,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0015926,GO:0016787,GO:0016798,GO:0033554,GO:0050896,GO:0051716	3.2.1.28	ko:K01194,ko:K03931	ko00500,ko01100,map00500,map01100	-	R00010	RC00049	ko00000,ko00001,ko00537,ko01000	-	GH37,GH63	-	Glyco_hydro_63,Trehalase
SHD1_k127_5227179_7	379066.GAU_2017	1.673e-49	197.0	COG1225@1|root,COG1225@2|Bacteria,1ZTY4@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	Redoxin	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
SHD1_k127_5227179_8	383372.Rcas_2633	1.804e-12	79.0	COG1276@1|root,COG2372@1|root,COG1276@2|Bacteria,COG2372@2|Bacteria,2G8KM@200795|Chloroflexi,377H2@32061|Chloroflexia	32061|Chloroflexia	P	copper resistance D domain protein	-	-	-	ko:K14166	-	-	-	-	ko00000,ko02000	-	-	-	CopC,CopD
SHD1_k127_5227179_2	861299.J421_3626	3.648e-155	514.0	COG5557@1|root,COG5557@2|Bacteria,1ZTCE@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Pfam Polysulphide reductase, NrfD	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_5227179_6	861299.J421_3627	1.694e-60	220.0	COG2010@1|root,COG2010@2|Bacteria,1ZTPK@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
SHD1_k127_5227179_5	861299.J421_3628	6.508e-66	232.0	COG2010@1|root,COG2010@2|Bacteria,1ZTMS@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Protein of unknown function (DUF3341)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3341
SHD1_k127_5227179_1	861299.J421_3629	8.763e-244	760.0	COG5557@1|root,COG5557@2|Bacteria,1ZSN2@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Polysulphide reductase, NrfD	-	-	-	ko:K00185	-	-	-	-	ko00000	5.A.3	-	-	NrfD
SHD1_k127_5227179_0	861299.J421_3630	0.0	1237.0	COG0243@1|root,COG0437@1|root,COG0243@2|Bacteria,COG0437@2|Bacteria,1ZSRY@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	4Fe-4S dicluster domain	-	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal
SHD1_k127_5227179_4	861299.J421_3631	6.366e-73	253.0	COG2010@1|root,COG2010@2|Bacteria,1ZTKA@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Cytochrome c7 and related cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C7
SHD1_k127_5227470_4	1125863.JAFN01000001_gene1615	3.328e-107	357.0	COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,42NBJ@68525|delta/epsilon subdivisions,2WJ52@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	PFAM magnesium chelatase ChlI subunit	comM	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
SHD1_k127_5227470_1	861299.J421_6359	7.742e-182	600.0	COG0577@1|root,COG0577@2|Bacteria	861299.J421_6359|-	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_5227470_9	861299.J421_0336	2.58e-33	131.0	COG1695@1|root,COG1695@2|Bacteria	2|Bacteria	K	negative regulation of transcription, DNA-templated	-	-	-	-	-	-	-	-	-	-	-	-	PadR
SHD1_k127_5227470_3	358823.DF19_29080	1.236e-134	436.0	COG1073@1|root,COG1073@2|Bacteria,2I345@201174|Actinobacteria	201174|Actinobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
SHD1_k127_5227470_5	379066.GAU_2547	7.332e-81	289.0	COG3266@1|root,COG3266@2|Bacteria,1ZT0N@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_5227470_2	1303518.CCALI_01058	2.529e-147	479.0	COG1522@1|root,COG1522@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	nirH	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_AsnC-type
SHD1_k127_5227470_0	1379270.AUXF01000005_gene461	1.906e-247	813.0	COG5000@1|root,COG5000@2|Bacteria,1ZSZU@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
SHD1_k127_5227470_6	861299.J421_2906	1.256e-80	277.0	COG1402@1|root,COG1402@2|Bacteria	2|Bacteria	I	creatininase	-	-	3.5.2.10	ko:K01470,ko:K22232	ko00330,ko00562,map00330,map00562	-	R01884,R11771	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
SHD1_k127_5227470_7	861299.J421_2905	2.453e-42	172.0	2FH8I@1|root,3492W@2|Bacteria,1ZTXF@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_5227470_8	861299.J421_2904	9.317e-40	158.0	COG1538@1|root,COG1538@2|Bacteria,1ZSMB@142182|Gemmatimonadetes	142182|Gemmatimonadetes	MU	Outer membrane efflux protein	-	-	-	ko:K12340	ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133	M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko02044	1.B.17,2.A.6.2	-	-	OEP
SHD1_k127_5248817_0	379066.GAU_1655	2.467e-134	435.0	COG1005@1|root,COG1005@2|Bacteria,1ZTDY@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	-	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
SHD1_k127_5248817_1	861299.J421_3287	2.026e-91	302.0	COG1143@1|root,COG1143@2|Bacteria,1ZTHB@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4_7
SHD1_k127_5248817_2	1379270.AUXF01000006_gene238	9.025e-53	194.0	COG0839@1|root,COG0839@2|Bacteria,1ZTSA@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	NADH-ubiquinone/plastoquinone oxidoreductase chain 6	-	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
SHD1_k127_5248817_3	861299.J421_3285	1.4e-38	155.0	COG0713@1|root,COG0713@2|Bacteria,1ZU00@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
SHD1_k127_5248817_4	861299.J421_3284	1.394e-27	118.0	COG1009@1|root,COG1009@2|Bacteria,1ZSZY@142182|Gemmatimonadetes	142182|Gemmatimonadetes	CP	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus	-	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
SHD1_k127_5252202_2	1379270.AUXF01000005_gene457	6.383e-123	396.0	COG1136@1|root,COG1136@2|Bacteria,1ZSKH@142182|Gemmatimonadetes	142182|Gemmatimonadetes	V	membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides	macB	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SHD1_k127_5252202_0	861299.J421_2901	7.569e-158	509.0	COG0577@1|root,COG0577@2|Bacteria,1ZSU3@142182|Gemmatimonadetes	2|Bacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
SHD1_k127_5252202_1	861299.J421_2900	1.448e-146	482.0	COG0577@1|root,COG0577@2|Bacteria,1ZUN6@142182|Gemmatimonadetes	142182|Gemmatimonadetes	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
SHD1_k127_5254253_0	861299.J421_3116	7.501e-198	622.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1ZT7J@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribBA	-	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2
SHD1_k127_5254253_1	861299.J421_3117	7.826e-61	213.0	COG0054@1|root,COG0054@2|Bacteria,1ZTPU@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	-	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
SHD1_k127_5254253_2	861299.J421_3118	5.759e-15	76.0	COG0781@1|root,COG0781@2|Bacteria,1ZTRU@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
SHD1_k127_5269050_5	717605.Theco_3174	1.58e-15	89.0	COG1216@1|root,COG1216@2|Bacteria,1V01C@1239|Firmicutes,4HEIS@91061|Bacilli,26RPQ@186822|Paenibacillaceae	91061|Bacilli	S	Uncharacterised nucleotidyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_5
SHD1_k127_5269050_3	247490.KSU1_C0427	5.073e-28	124.0	COG0842@1|root,COG0842@2|Bacteria	2|Bacteria	V	Transport permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
SHD1_k127_5269050_1	247490.KSU1_C0426	6.472e-64	233.0	COG1131@1|root,COG1131@2|Bacteria,2IZYW@203682|Planctomycetes	203682|Planctomycetes	V	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,DUF4162
SHD1_k127_5269050_4	1284352.AOIG01000004_gene1253	4.32e-16	89.0	COG1493@1|root,COG1493@2|Bacteria,1V4IV@1239|Firmicutes,4HGBQ@91061|Bacilli,26SXR@186822|Paenibacillaceae	91061|Bacilli	T	Serine kinase of the HPr protein, regulates carbohydrate metabolism	hprK3	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,Hpr_kinase_C
SHD1_k127_5269050_2	1298858.AUEL01000005_gene1231	1.995e-35	155.0	COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,2TSCY@28211|Alphaproteobacteria,43IMQ@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Asparagine synthase	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
SHD1_k127_5269050_7	1121033.AUCF01000044_gene4607	0.0001684	50.0	2ESXU@1|root,33KG4@2|Bacteria,1NMBC@1224|Proteobacteria,2VGVD@28211|Alphaproteobacteria,2JXTM@204441|Rhodospirillales	204441|Rhodospirillales	S	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core3
SHD1_k127_5269050_6	1044.EH31_16895	2.555e-08	59.0	2DRDY@1|root,33BC0@2|Bacteria	2|Bacteria	S	PFAM Coenzyme PQQ synthesis protein D (PqqD)	-	-	-	-	-	-	-	-	-	-	-	-	PqqD
SHD1_k127_5269050_0	1379270.AUXF01000002_gene1599	6.145e-111	371.0	COG0515@1|root,COG0515@2|Bacteria	1379270.AUXF01000002_gene1599|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_5269504_0	861299.J421_2334	2.192e-78	272.0	COG1331@1|root,COG1331@2|Bacteria	2|Bacteria	O	Highly conserved protein containing a thioredoxin domain	yyaL	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	GlcNAc_2-epim,Thioredox_DsbH
SHD1_k127_5269504_2	535289.Dtpsy_3022	1.742e-15	80.0	2DMYI@1|root,32UE4@2|Bacteria,1N1WA@1224|Proteobacteria,2WFYE@28216|Betaproteobacteria,4AEVP@80864|Comamonadaceae	28216|Betaproteobacteria	S	YXWGXW repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	YXWGXW
SHD1_k127_5269504_1	861299.J421_2130	3.179e-53	192.0	COG0515@1|root,COG0664@1|root,COG0515@2|Bacteria,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	pp2c12	-	2.7.11.1,3.1.3.16	ko:K12132,ko:K20074	-	-	-	-	ko00000,ko01000,ko01001,ko01009	-	-	-	PP2C_2,Pkinase,cNMP_binding
SHD1_k127_5287177_0	861299.J421_0079	1.197e-229	719.0	COG0514@1|root,COG0514@2|Bacteria,1ZSNS@142182|Gemmatimonadetes	2|Bacteria	L	RecQ zinc-binding	recQ	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,DUF3553,HRDC,Helicase_C,RecQ_Zn_bind
SHD1_k127_5287177_1	861299.J421_4245	2.579e-34	138.0	COG3011@1|root,COG3011@2|Bacteria	2|Bacteria	CH	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF393,VKG_Carbox
SHD1_k127_5299242_2	472759.Nhal_1378	6.251e-79	271.0	COG1028@1|root,COG1028@2|Bacteria,1MW9A@1224|Proteobacteria,1RMMZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	IQ	Dehydrogenases with different specificities (Related to short-chain alcohol dehydrogenases)	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short,adh_short_C2
SHD1_k127_5299242_6	671143.DAMO_2649	6.79e-49	177.0	COG2154@1|root,COG2154@2|Bacteria,2NQ7C@2323|unclassified Bacteria	2|Bacteria	H	Pterin 4 alpha carbinolamine dehydratase	phhB	-	3.5.4.33,4.2.1.96	ko:K01724,ko:K11991	ko00790,map00790	-	R04734,R10223	RC00477,RC01208	ko00000,ko00001,ko01000,ko03016,ko04147	-	-	-	Polyketide_cyc2,Pterin_4a
SHD1_k127_5299242_0	1380390.JIAT01000010_gene4319	1.486e-147	481.0	COG0294@1|root,COG0294@2|Bacteria	2|Bacteria	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	-	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
SHD1_k127_5299242_1	1121468.AUBR01000030_gene1251	3.376e-130	432.0	COG0147@1|root,COG0147@2|Bacteria,1TQAP@1239|Firmicutes,24946@186801|Clostridia,42FM5@68295|Thermoanaerobacterales	186801|Clostridia	EH	Anthranilate synthase component I, N terminal region	pabB	-	2.6.1.85,4.1.3.27	ko:K01657,ko:K01665,ko:K13950	ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986,R01716	RC00010,RC01418,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind,GATase
SHD1_k127_5299242_3	743719.PaelaDRAFT_5752	4.414e-69	248.0	COG0512@1|root,COG0512@2|Bacteria,1TT9R@1239|Firmicutes,4H9XP@91061|Bacilli,26SGI@186822|Paenibacillaceae	91061|Bacilli	EH	with TrpE catalyzes the formation of anthranilate and glutamate from chorismate and glutamine	pabA	-	2.6.1.85,4.1.3.27	ko:K01658,ko:K01664	ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986,R01716	RC00010,RC01418,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
SHD1_k127_5299242_4	1121033.AUCF01000026_gene2960	8.607e-54	207.0	COG0115@1|root,COG0115@2|Bacteria,1MZAK@1224|Proteobacteria,2U9QU@28211|Alphaproteobacteria,2JRSK@204441|Rhodospirillales	204441|Rhodospirillales	EH	Aminotransferase	-	-	2.6.1.42,4.1.3.38	ko:K00826,ko:K02619	ko00270,ko00280,ko00290,ko00770,ko00790,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map00790,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R05553,R10991	RC00006,RC00036,RC01843,RC02148	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
SHD1_k127_5299242_5	1380390.JIAT01000010_gene4330	2.125e-52	189.0	COG2457@1|root,COG2457@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF447)	-	-	-	ko:K09154	-	-	-	-	ko00000	-	-	-	DUF447
SHD1_k127_5311983_2	269799.Gmet_0979	7.246e-08	63.0	COG0457@1|root,COG0457@2|Bacteria,1NEMW@1224|Proteobacteria,42WBX@68525|delta/epsilon subdivisions,2WRAD@28221|Deltaproteobacteria,43VAR@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_14,TPR_16,TPR_19,TPR_8
SHD1_k127_5311983_3	404589.Anae109_3759	0.0004594	51.0	COG2018@1|root,COG2018@2|Bacteria,1RDN5@1224|Proteobacteria,42S13@68525|delta/epsilon subdivisions,2WNKB@28221|Deltaproteobacteria,2YV9Q@29|Myxococcales	28221|Deltaproteobacteria	S	Roadblock/LC7 domain	mglB	-	-	-	-	-	-	-	-	-	-	-	Robl_LC7
SHD1_k127_5311983_1	861299.J421_3059	6.313e-87	291.0	COG1100@1|root,COG1100@2|Bacteria,1ZTK3@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Small GTP-binding protein	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	Arf
SHD1_k127_5311983_0	379066.GAU_1411	5.707e-155	519.0	COG0593@1|root,COG0593@2|Bacteria,1ZUFJ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	Bacterial dnaA  protein	-	-	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA
SHD1_k127_5320511_4	391038.Bphy_4609	1.104e-27	117.0	COG5483@1|root,COG5483@2|Bacteria,1RDGV@1224|Proteobacteria,2VV76@28216|Betaproteobacteria,1K45P@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Protein of unknown function, DUF488	-	-	-	-	-	-	-	-	-	-	-	-	DUF488
SHD1_k127_5320511_3	861299.J421_5685	1.475e-40	154.0	COG2346@1|root,COG2346@2|Bacteria	2|Bacteria	O	COG2346, Truncated hemoglobins	ctb	-	-	ko:K06886	-	-	-	-	ko00000	-	-	-	Bac_globin
SHD1_k127_5320511_2	485913.Krac_2611	4.906e-45	171.0	2BHPS@1|root,32BT1@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_5320511_1	522306.CAP2UW1_3971	9.011e-50	188.0	COG5266@1|root,COG5266@2|Bacteria,1NFTH@1224|Proteobacteria,2VVQE@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Domain of unknown function (DUF4198)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4198
SHD1_k127_5320511_0	1267534.KB906758_gene2106	2.777e-78	266.0	COG2818@1|root,COG2818@2|Bacteria,3Y4FW@57723|Acidobacteria,2JJ2V@204432|Acidobacteriia	204432|Acidobacteriia	L	TIGRFAM DNA-3-methyladenine glycosylase I	-	-	3.2.2.20	ko:K01246	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Adenine_glyco
SHD1_k127_5320511_5	1500897.JQNA01000002_gene4345	2.097e-18	88.0	COG5486@1|root,COG5486@2|Bacteria,1NFSK@1224|Proteobacteria,2W1ES@28216|Betaproteobacteria,1K46J@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Predicted metal-binding integral membrane protein (DUF2182)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2182
SHD1_k127_5321207_0	1279009.ADICEAN_00704	2.283e-61	229.0	COG0697@1|root,COG0697@2|Bacteria,4NEHX@976|Bacteroidetes,47MRR@768503|Cytophagia	976|Bacteroidetes	EG	PFAM EamA-like transporter family	fjo11	-	-	-	-	-	-	-	-	-	-	-	EamA
SHD1_k127_5328673_0	479432.Sros_4028	1.156e-122	410.0	COG0492@1|root,COG0664@1|root,COG0492@2|Bacteria,COG0664@2|Bacteria,2GK62@201174|Actinobacteria,4EN6B@85012|Streptosporangiales	201174|Actinobacteria	C	Cyclic nucleotide-monophosphate binding domain	trxB2	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,cNMP_binding
SHD1_k127_5328673_1	1056512.D515_02082	0.0002935	50.0	2DS8R@1|root,33F1A@2|Bacteria,1MZBA@1224|Proteobacteria,1SBM3@1236|Gammaproteobacteria,1Y165@135623|Vibrionales	135623|Vibrionales	S	Protein of unknown function (DUF2380)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3280
SHD1_k127_5347172_6	379066.GAU_1890	5.956e-27	115.0	COG1579@1|root,COG1579@2|Bacteria,1ZU01@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Zn-ribbon protein possibly nucleic acid-binding	-	-	-	ko:K07164	-	-	-	-	ko00000	-	-	-	-
SHD1_k127_5347172_0	379066.GAU_1889	1.064e-184	594.0	COG0608@1|root,COG0608@2|Bacteria,1ZTGC@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	DHH family	-	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
SHD1_k127_5347172_3	861299.J421_3458	1.793e-55	207.0	COG0742@1|root,COG0742@2|Bacteria,1ZTVS@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	Conserved hypothetical protein 95	-	-	2.1.1.171	ko:K08316	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Cons_hypoth95
SHD1_k127_5347172_2	1379270.AUXF01000006_gene73	3.103e-65	227.0	COG0669@1|root,COG0669@2|Bacteria,1ZTTQ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	-	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
SHD1_k127_5347172_4	861299.J421_3455	2.47e-54	194.0	COG1366@1|root,COG1366@2|Bacteria,1ZTXM@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	STAS domain	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS
SHD1_k127_5347172_5	861299.J421_3454	7.623e-38	149.0	COG2172@1|root,COG2172@2|Bacteria,1ZU34@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	Histidine kinase-like ATPase domain	-	-	2.7.11.1	ko:K04757	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	HATPase_c_2
SHD1_k127_5347172_1	861299.J421_3453	1.034e-99	335.0	COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,1ZSPW@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KT	Sigma factor PP2C-like phosphatases	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	SpoIIE
SHD1_k127_5349295_0	379066.GAU_1730	1.708e-136	447.0	COG0265@1|root,COG0265@2|Bacteria,1ZTAM@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	Trypsin	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
SHD1_k127_5349295_1	861299.J421_3370	2.258e-41	159.0	COG0176@1|root,COG0176@2|Bacteria	2|Bacteria	G	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016829,GO:0016830,GO:0016832,GO:0044424,GO:0044464,GO:0097023	2.2.1.2	ko:K00616,ko:K08313,ko:K08314	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	iB21_1397.B21_03781,iEC042_1314.EC042_0914,iECBD_1354.ECBD_4077,iECB_1328.ECB_03832,iECD_1391.ECD_03832,iECH74115_1262.ECH74115_5407,iECSP_1301.ECSP_5016,iECs_1301.ECs4875,iEcHS_1320.EcHS_A4181,iG2583_1286.G2583_4758,iSBO_1134.SBO_0715,iSF_1195.SF0775,iSFxv_1172.SFxv_0845,iS_1188.S0818,iZ_1308.Z5501	TAL_FSA
SHD1_k127_5363943_2	1267535.KB906767_gene410	5.642e-53	197.0	COG4760@1|root,COG4760@2|Bacteria,3Y6G0@57723|Acidobacteria,2JM96@204432|Acidobacteriia	204432|Acidobacteriia	S	Bax inhibitor 1 like	-	-	-	-	-	-	-	-	-	-	-	-	BaxI_1
SHD1_k127_5363943_3	91464.S7335_326	2.401e-20	94.0	COG1308@1|root,COG1308@2|Bacteria,1G83N@1117|Cyanobacteria,1H3C4@1129|Synechococcus	1117|Cyanobacteria	K	Domain of unknown function (DUF4342)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4342
SHD1_k127_5363943_1	1430440.MGMSRv2_3614	6.768e-99	328.0	COG0603@1|root,COG0603@2|Bacteria,1MU5V@1224|Proteobacteria,2TU7F@28211|Alphaproteobacteria,2JTE6@204441|Rhodospirillales	204441|Rhodospirillales	F	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))	queC	-	6.3.4.20	ko:K06920	ko00790,ko01100,map00790,map01100	-	R09978	RC00959	ko00000,ko00001,ko01000,ko03016	-	-	-	QueC
SHD1_k127_5363943_0	479435.Kfla_0827	1.127e-99	329.0	COG0602@1|root,COG0602@2|Bacteria,2I9R3@201174|Actinobacteria,4DSU3@85009|Propionibacteriales	201174|Actinobacteria	H	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds	queE	-	4.3.99.3	ko:K10026	ko00790,ko01100,map00790,map01100	-	R10002	RC02989	ko00000,ko00001,ko01000,ko03016	-	-	-	Fer4_14,Radical_SAM
SHD1_k127_5365241_3	1379270.AUXF01000006_gene271	5.571e-73	247.0	COG1137@1|root,COG1137@2|Bacteria,1ZT4S@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	ABC transporter	-	-	-	ko:K06861	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	1.B.42.1	-	-	ABC_tran
SHD1_k127_5365241_1	861299.J421_3250	9.749e-244	762.0	COG1508@1|root,COG1508@2|Bacteria,1ZT13@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Sigma-54 factor, Activator interacting domain (AID)	-	-	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
SHD1_k127_5365241_2	861299.J421_3249	1.106e-135	444.0	COG0463@1|root,COG0463@2|Bacteria,1ZTEI@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
SHD1_k127_5365241_4	1379270.AUXF01000006_gene275	1.395e-40	163.0	COG0392@1|root,COG0392@2|Bacteria,1ZTX4@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
SHD1_k127_5365241_0	861299.J421_3246	9.047e-266	841.0	COG5617@1|root,COG5617@2|Bacteria,1ZUMG@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Bacterial membrane protein YfhO	-	-	-	-	-	-	-	-	-	-	-	-	YfhO
SHD1_k127_5365241_5	379066.GAU_1612	0.0002762	46.0	COG0463@1|root,COG0463@2|Bacteria,1ZT31@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	Glycosyltransferase like family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
SHD1_k127_5374507_0	861299.J421_3780	5.946e-255	793.0	COG0178@1|root,COG0178@2|Bacteria,1ZT1W@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	-	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
SHD1_k127_5377929_0	379066.GAU_2785	7.99e-247	776.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1ZTC2@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	NAD synthase	-	-	6.3.1.5	ko:K01916	ko00760,ko01100,map00760,map01100	M00115	R00189	RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
SHD1_k127_5385061_2	861299.J421_2975	2.596e-94	316.0	COG0313@1|root,COG0313@2|Bacteria,1ZTK1@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	-	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
SHD1_k127_5385061_1	861299.J421_2976	1.574e-108	356.0	COG1657@1|root,COG1657@2|Bacteria,1ZSPV@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Domain of unknown function (DUF4159)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4159
SHD1_k127_5385061_0	861299.J421_2977	1.835e-112	385.0	COG1196@1|root,COG4942@1|root,COG1196@2|Bacteria,COG4942@2|Bacteria,1ZSU8@142182|Gemmatimonadetes	142182|Gemmatimonadetes	D	nuclear chromosome segregation	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_5392854_0	1506583.JQJY01000004_gene2623	7.683e-111	377.0	COG0277@1|root,COG0277@2|Bacteria,4PCSU@976|Bacteroidetes,1IF9Z@117743|Flavobacteriia,2NYPA@237|Flavobacterium	976|Bacteroidetes	C	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_4
SHD1_k127_5392854_1	504472.Slin_6094	2.667e-29	123.0	COG3408@1|root,COG3408@2|Bacteria,4NHUB@976|Bacteroidetes,47N0U@768503|Cytophagia	976|Bacteroidetes	G	Glycogen debranching enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Bac_rhamnosid6H
SHD1_k127_5399095_1	861299.J421_5977	2.556e-74	261.0	COG0665@1|root,COG0665@2|Bacteria,1ZUQF@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
SHD1_k127_5399095_0	1128421.JAGA01000001_gene2203	1.933e-150	488.0	COG4579@1|root,COG4579@2|Bacteria	2|Bacteria	F	[isocitrate dehydrogenase (NADP+)] phosphatase activity	aceK	GO:0000166,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0004721,GO:0004722,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006081,GO:0006082,GO:0006091,GO:0006097,GO:0006099,GO:0006101,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008772,GO:0009060,GO:0009987,GO:0015980,GO:0016208,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016787,GO:0016788,GO:0016791,GO:0016999,GO:0017076,GO:0017144,GO:0018105,GO:0018193,GO:0018209,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0035639,GO:0036094,GO:0036211,GO:0042578,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044260,GO:0044262,GO:0044267,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046487,GO:0050790,GO:0055114,GO:0065007,GO:0065009,GO:0070262,GO:0071704,GO:0072350,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564	2.7.11.5	ko:K00906	-	-	-	-	ko00000,ko01000	-	-	-	AceK
SHD1_k127_5406913_1	196367.JNFG01000215_gene829	2.817e-40	151.0	COG1309@1|root,COG1309@2|Bacteria,1N1Q3@1224|Proteobacteria,2VNVW@28216|Betaproteobacteria,1K1WH@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
SHD1_k127_5406913_0	948106.AWZT01000001_gene5498	7.428e-119	391.0	COG4221@1|root,COG4221@2|Bacteria,1R83E@1224|Proteobacteria,2VR3Z@28216|Betaproteobacteria,1KIHI@119060|Burkholderiaceae	28216|Betaproteobacteria	S	NAD dependent epimerase/dehydratase family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
SHD1_k127_5414768_3	861299.J421_1943	1.175e-54	209.0	COG3391@1|root,COG3391@2|Bacteria,1ZV9B@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_5414768_1	234267.Acid_0798	1.464e-110	381.0	COG4805@1|root,COG4805@2|Bacteria,3Y468@57723|Acidobacteria	57723|Acidobacteria	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
SHD1_k127_5414768_2	379066.GAU_3005	1.098e-68	243.0	COG0631@1|root,COG0631@2|Bacteria,1ZSPY@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	Serine/threonine phosphatases, family 2C, catalytic domain	-	-	3.1.3.16	ko:K01090,ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C_2
SHD1_k127_5414768_0	1379270.AUXF01000002_gene1599	1.959e-126	417.0	COG0515@1|root,COG0515@2|Bacteria	1379270.AUXF01000002_gene1599|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_5416776_0	861299.J421_0588	5.933e-246	784.0	COG4447@1|root,COG4447@2|Bacteria,1ZSRH@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Sortilin, neurotensin receptor 3,	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
SHD1_k127_5416776_1	1380394.JADL01000012_gene975	5.097e-57	203.0	COG3844@1|root,COG3844@2|Bacteria,1MUKN@1224|Proteobacteria,2TR62@28211|Alphaproteobacteria,2JR6H@204441|Rhodospirillales	204441|Rhodospirillales	E	Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively	kynU	-	3.7.1.3	ko:K01556	ko00380,ko01100,map00380,map01100	M00038	R00987,R02668,R03936	RC00284,RC00415	ko00000,ko00001,ko00002,ko01000	-	-	-	Aminotran_5
SHD1_k127_543102_3	861299.J421_0290	3.011e-138	452.0	COG0845@1|root,COG0845@2|Bacteria,1ZUP2@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_3
SHD1_k127_543102_4	1340493.JNIF01000003_gene4405	4.84e-111	365.0	COG1136@1|root,COG1136@2|Bacteria,3Y2J0@57723|Acidobacteria	57723|Acidobacteria	V	PFAM ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SHD1_k127_543102_0	251221.35211765	5.203e-192	626.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
SHD1_k127_543102_1	1267535.KB906767_gene629	1.041e-182	582.0	COG2204@1|root,COG2204@2|Bacteria,3Y33M@57723|Acidobacteria,2JHW9@204432|Acidobacteriia	204432|Acidobacteriia	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
SHD1_k127_543102_2	234267.Acid_4169	6.508e-150	487.0	COG5000@1|root,COG5000@2|Bacteria,3Y2TD@57723|Acidobacteria	57723|Acidobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
SHD1_k127_543102_7	379066.GAU_2621	1.436e-18	96.0	2A1DQ@1|root,30PKX@2|Bacteria,1ZUYB@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_543102_5	383372.Rcas_1339	1.764e-66	237.0	COG1407@1|root,COG1407@2|Bacteria	2|Bacteria	S	Calcineurin-like phosphoesterase	MA20_22045	-	-	ko:K06953	-	-	-	-	ko00000	-	-	-	Metallophos
SHD1_k127_543102_6	357808.RoseRS_3430	9.317e-48	174.0	COG1201@1|root,COG1201@2|Bacteria	2|Bacteria	L	RNA secondary structure unwinding	lhr	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
SHD1_k127_5441968_5	926554.KI912672_gene58	3.357e-18	87.0	COG0300@1|root,COG0300@2|Bacteria,1WM9V@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	NAD(P)H-binding	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
SHD1_k127_5441968_6	1077144.AGFF01000005_gene2138	1.654e-17	91.0	COG0671@1|root,COG0671@2|Bacteria	2|Bacteria	I	phosphatidate phosphatase activity	-	-	3.1.3.2,3.6.1.27	ko:K09474,ko:K19302	ko00550,ko00740,ko01100,ko02020,map00550,map00740,map01100,map02020	-	R00548,R05627	RC00002,RC00017	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
SHD1_k127_5441968_1	861299.J421_0838	3.184e-189	609.0	COG0446@1|root,COG2146@1|root,COG0446@2|Bacteria,COG2146@2|Bacteria,1ZV6A@142182|Gemmatimonadetes	142182|Gemmatimonadetes	P	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2
SHD1_k127_5441968_3	861299.J421_3736	3.728e-119	392.0	COG2898@1|root,COG2898@2|Bacteria,1ZTYA@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Uncharacterised conserved protein (DUF2156)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2156
SHD1_k127_5441968_0	1120919.AUBI01000010_gene134	5.486e-258	809.0	COG2936@1|root,COG2936@2|Bacteria,1MVA8@1224|Proteobacteria,2U29S@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	X-Pro dipeptidyl-peptidase domain protein	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
SHD1_k127_5441968_2	1122137.AQXF01000003_gene2417	8.101e-165	550.0	COG2234@1|root,COG2234@2|Bacteria,1NVWC@1224|Proteobacteria	1224|Proteobacteria	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
SHD1_k127_5441968_4	1122137.AQXF01000003_gene2417	8.06e-88	305.0	COG2234@1|root,COG2234@2|Bacteria,1NVWC@1224|Proteobacteria	1224|Proteobacteria	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
SHD1_k127_545507_1	1278073.MYSTI_01758	2.809e-50	192.0	COG2972@1|root,COG2972@2|Bacteria,1MXVQ@1224|Proteobacteria,42R4U@68525|delta/epsilon subdivisions,2X799@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K08082	ko02020,map02020	M00493	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,His_kinase
SHD1_k127_545507_0	1121920.AUAU01000004_gene852	2.03e-56	204.0	COG3279@1|root,COG3279@2|Bacteria,3Y4VI@57723|Acidobacteria	57723|Acidobacteria	T	LytTr DNA-binding domain	-	-	-	ko:K02477	-	-	-	-	ko00000,ko02022	-	-	-	LytTR,Response_reg
SHD1_k127_5457651_1	861299.J421_5949	2.133e-66	247.0	COG0515@1|root,COG0515@2|Bacteria	861299.J421_5949|-	KLT	protein kinase activity	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	-
SHD1_k127_5457651_2	1379270.AUXF01000002_gene1484	1.675e-43	166.0	2B3Y0@1|root,31WN1@2|Bacteria,1ZUEY@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_5457651_0	861299.J421_5836	3.462e-99	357.0	COG0515@1|root,COG0515@2|Bacteria	861299.J421_5836|-	KLT	protein kinase activity	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	-
SHD1_k127_5458802_8	379066.GAU_0458	3.159e-66	228.0	COG1351@1|root,COG1351@2|Bacteria,1ZTEP@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant	thyX	-	2.1.1.148	ko:K03465	ko00240,ko00670,ko01100,map00240,map00670,map01100	-	R06613	RC00022,RC00332	ko00000,ko00001,ko01000	-	-	-	Thy1
SHD1_k127_5458802_7	1191523.MROS_1829	1.81e-106	360.0	COG1181@1|root,COG1181@2|Bacteria	2|Bacteria	F	Belongs to the D-alanine--D-alanine ligase family	ddlA	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
SHD1_k127_5458802_11	1121918.ARWE01000001_gene2996	7.329e-50	191.0	COG1181@1|root,COG1181@2|Bacteria,1N4F5@1224|Proteobacteria,42NYM@68525|delta/epsilon subdivisions,2WKTX@28221|Deltaproteobacteria,43U6N@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	ATP-grasp domain	-	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
SHD1_k127_5458802_15	1121861.KB899916_gene1705	5.499e-28	121.0	COG0454@1|root,COG1181@1|root,COG0456@2|Bacteria,COG1181@2|Bacteria,1N4F5@1224|Proteobacteria,2U1M9@28211|Alphaproteobacteria,2JYEI@204441|Rhodospirillales	204441|Rhodospirillales	M	ATP-grasp domain	-	-	-	-	-	-	-	-	-	-	-	-	Dala_Dala_lig_C
SHD1_k127_5458802_5	945713.IALB_3087	9.401e-131	426.0	COG1509@1|root,COG1509@2|Bacteria	2|Bacteria	E	lysine 2,3-aminomutase activity	kamA	-	5.4.3.2	ko:K01843	ko00310,map00310	-	R00461	RC00303	ko00000,ko00001,ko01000	-	-	-	Fer4_14,LAM_C,Radical_SAM
SHD1_k127_5458802_12	1163409.UUA_10886	1.265e-46	175.0	COG3795@1|root,COG3795@2|Bacteria,1N32U@1224|Proteobacteria,1S82G@1236|Gammaproteobacteria,1X765@135614|Xanthomonadales	135614|Xanthomonadales	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	YCII
SHD1_k127_5458802_4	861299.J421_6092	3.3e-140	462.0	COG1680@1|root,COG1680@2|Bacteria,1ZUKR@142182|Gemmatimonadetes	142182|Gemmatimonadetes	V	Domain of unknown function (DUF3471)	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,DUF3471
SHD1_k127_5458802_13	861299.J421_2355	3.833e-42	164.0	2F8RH@1|root,3413Q@2|Bacteria,1ZTWC@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_5458802_17	543728.Vapar_2006	1.95e-07	59.0	2DPIK@1|root,32UM7@2|Bacteria,1MZQR@1224|Proteobacteria,2VUE4@28216|Betaproteobacteria,4AEXA@80864|Comamonadaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_5458802_9	383372.Rcas_2599	5.465e-63	224.0	COG0745@1|root,COG0745@2|Bacteria,2G6MM@200795|Chloroflexi,376T7@32061|Chloroflexia	32061|Chloroflexia	K	Two component transcriptional regulator, winged helix family	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
SHD1_k127_5458802_1	234267.Acid_4487	2.776e-220	703.0	COG1132@1|root,COG1132@2|Bacteria	2|Bacteria	V	(ABC) transporter	-	-	-	ko:K06147,ko:K06148	-	-	-	-	ko00000,ko02000	3.A.1,3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
SHD1_k127_5458802_6	1379270.AUXF01000002_gene1787	4.276e-108	364.0	COG0726@1|root,COG0726@2|Bacteria,1ZSTP@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
SHD1_k127_5458802_10	379066.GAU_0447	1.151e-61	218.0	2F2MH@1|root,33VI3@2|Bacteria,1ZTMG@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_5458802_2	1379270.AUXF01000002_gene1784	5.888e-182	585.0	COG1158@1|root,COG1158@2|Bacteria,1ZTA0@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	-	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_RNA_bind
SHD1_k127_5458802_3	861299.J421_2338	6.283e-163	539.0	COG4775@1|root,COG4775@2|Bacteria,1ZSY7@142182|Gemmatimonadetes	2|Bacteria	M	Surface antigen	-	-	-	ko:K07277,ko:K07278	-	-	-	-	ko00000,ko02000,ko03029	1.B.33,1.B.33.2.4	-	-	Bac_surface_Ag,CarboxypepD_reg,Laminin_G_3,POTRA
SHD1_k127_5458802_0	861299.J421_2339	3e-323	1054.0	COG2911@1|root,COG2911@2|Bacteria,1ZT97@142182|Gemmatimonadetes	2|Bacteria	S	TamB, inner membrane protein subunit of TAM complex	tamB	-	-	ko:K09800	-	-	-	-	ko00000,ko02000	-	-	-	TamB
SHD1_k127_5458802_14	1078085.HMPREF1210_02804	1.302e-35	142.0	COG5580@1|root,COG5580@2|Bacteria,1VXSU@1239|Firmicutes,4HXVJ@91061|Bacilli	91061|Bacilli	O	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
SHD1_k127_5458802_16	861299.J421_2051	5.634e-14	81.0	COG1028@1|root,COG1028@2|Bacteria	861299.J421_2051|-	IQ	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_5469234_1	861299.J421_4336	1.546e-132	436.0	COG1306@1|root,COG1306@2|Bacteria	2|Bacteria	S	Putative glycosyl hydrolase domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4015
SHD1_k127_5469234_0	861299.J421_4340	5.413e-140	467.0	COG0520@1|root,COG0520@2|Bacteria,1ZSV8@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
SHD1_k127_5469234_2	861299.J421_4341	4.218e-112	369.0	COG2084@1|root,COG2084@2|Bacteria,1ZT54@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	-	-	1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
SHD1_k127_5479612_1	861299.J421_4539	9.319e-31	129.0	28YSJ@1|root,2ZKJZ@2|Bacteria,1ZU1U@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_5479612_2	861299.J421_4420	3.768e-29	124.0	COG0296@1|root,COG0296@2|Bacteria,1ZUZV@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	Glycogen recognition site of AMP-activated protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_5479612_0	861299.J421_4541	4.33e-64	229.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	sigX	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
SHD1_k127_5479612_3	861299.J421_4422	2.859e-23	100.0	2C9AW@1|root,2ZVNX@2|Bacteria,1ZUAK@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_5484683_0	861299.J421_2117	2.478e-107	356.0	COG0492@1|root,COG0492@2|Bacteria,1ZV3D@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2
SHD1_k127_5484683_1	861299.J421_2118	1.268e-69	246.0	COG5549@1|root,COG5549@2|Bacteria,1ZTQC@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	Matrixin	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M10
SHD1_k127_5484683_2	1217718.ALOU01000019_gene2751	3.024e-66	231.0	COG0431@1|root,COG0431@2|Bacteria,1RAFI@1224|Proteobacteria,2VKQS@28216|Betaproteobacteria,1K02Y@119060|Burkholderiaceae	28216|Betaproteobacteria	S	NADPH-dependent FMN reductase	azr	-	-	ko:K19784	-	-	-	-	ko00000	-	-	-	FMN_red
SHD1_k127_5484683_3	861299.J421_2173	1.819e-19	89.0	COG0457@1|root,COG0457@2|Bacteria	861299.J421_2173|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_5489351_4	1278073.MYSTI_00515	1.512e-18	97.0	COG0845@1|root,COG0845@2|Bacteria,1MX0G@1224|Proteobacteria,42RBE@68525|delta/epsilon subdivisions,2WN7J@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
SHD1_k127_5489351_1	861299.J421_2015	1.515e-107	368.0	COG1538@1|root,COG1538@2|Bacteria,1ZSR9@142182|Gemmatimonadetes	142182|Gemmatimonadetes	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
SHD1_k127_5489351_2	530564.Psta_0826	3.846e-49	183.0	COG3685@1|root,COG3685@2|Bacteria,2IZPC@203682|Planctomycetes	203682|Planctomycetes	S	Domain of unknown function (DUF892)	-	-	-	-	-	-	-	-	-	-	-	-	DUF892
SHD1_k127_5489351_0	1128421.JAGA01000002_gene335	5.617e-154	499.0	COG2124@1|root,COG2124@2|Bacteria	2|Bacteria	Q	cytochrome p450	-	-	-	-	-	-	-	-	-	-	-	-	p450
SHD1_k127_5489351_3	861299.J421_2007	2.328e-29	124.0	COG4262@1|root,COG4262@2|Bacteria,1ZU7C@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	speE	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synth
SHD1_k127_5490201_2	1128421.JAGA01000002_gene746	6.684e-10	64.0	COG0438@1|root,COG0438@2|Bacteria,2NRC9@2323|unclassified Bacteria	2|Bacteria	M	Glycosyl transferases group 1	pslH	-	-	ko:K21001	ko02025,map02025	-	-	-	ko00000,ko00001,ko01003	-	GT4	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4
SHD1_k127_5490201_1	861299.J421_1046	1.043e-17	85.0	2EIK5@1|root,33CBF@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_5490201_0	926560.KE387025_gene4151	6.944e-40	171.0	COG1404@1|root,COG1404@2|Bacteria,1WJ91@1297|Deinococcus-Thermus	2|Bacteria	O	peptidase S8 and S53, subtilisin, kexin, sedolisin	-	-	-	ko:K14645	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	Big_5,Peptidase_S8,TIG,VCBS
SHD1_k127_5490201_3	1123405.AUMM01000031_gene1488	1.389e-07	53.0	2DTS4@1|root,33MFD@2|Bacteria,1VKHK@1239|Firmicutes,4I120@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_5494694_0	861299.J421_2994	0.0	1012.0	COG0525@1|root,COG0525@2|Bacteria,1ZSXQ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
SHD1_k127_5494694_3	861299.J421_2996	1.998e-43	183.0	2FBQ3@1|root,343V1@2|Bacteria,1ZU1R@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	BON domain	-	-	-	-	-	-	-	-	-	-	-	-	BON
SHD1_k127_5494694_1	861299.J421_2997	3.538e-233	739.0	COG0441@1|root,COG0441@2|Bacteria,1ZT2I@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
SHD1_k127_5494694_2	861299.J421_3000	3.664e-177	563.0	COG0183@1|root,COG0183@2|Bacteria,1ZTGX@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Thiolase, C-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
SHD1_k127_5501445_3	861299.J421_3421	8.246e-77	264.0	COG0283@1|root,COG0283@2|Bacteria,1ZSNA@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	cmk	-	2.5.1.19,2.7.4.25	ko:K00800,ko:K00945	ko00240,ko00400,ko01100,ko01110,ko01130,ko01230,map00240,map00400,map01100,map01110,map01130,map01230	M00022,M00052	R00158,R00512,R01665,R03460	RC00002,RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin,EPSP_synthase
SHD1_k127_5501445_0	861299.J421_3422	3.725e-150	486.0	COG0128@1|root,COG0128@2|Bacteria	2|Bacteria	E	3-phosphoshikimate 1-carboxyvinyltransferase activity	aroA	GO:0003674,GO:0003824,GO:0003866,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0071704,GO:0071944,GO:1901576	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	iEC042_1314.EC042_0998,iECNA114_1301.ECNA114_0940,iECSF_1327.ECSF_0829,iPC815.YPO1390	EPSP_synthase
SHD1_k127_5501445_5	1122933.JNIY01000003_gene830	6.543e-22	109.0	COG0287@1|root,COG0287@2|Bacteria,2GKB4@201174|Actinobacteria,4F1J5@85016|Cellulomonadaceae	201174|Actinobacteria	E	amino acid-binding ACT domain protein	tyrA	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006520,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008977,GO:0009058,GO:0009072,GO:0009073,GO:0009095,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019438,GO:0019752,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0070403,GO:0071704,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.3.1.12	ko:K00210,ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025	R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	PDH
SHD1_k127_5501445_2	861299.J421_3423	2.95e-107	357.0	COG2171@1|root,COG2171@2|Bacteria,1ZT1D@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Tetrahydrodipicolinate N-succinyltransferase N-terminal	-	-	2.3.1.117	ko:K00674	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R04365	RC00004,RC01136	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep_2,THDPS_N_2
SHD1_k127_5501445_1	1379270.AUXF01000006_gene103	5.37e-131	434.0	COG0136@1|root,COG0136@2|Bacteria,1ZTBS@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Semialdehyde dehydrogenase, NAD binding domain	-	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
SHD1_k127_5501445_4	379066.GAU_1796	2e-58	206.0	COG0624@1|root,COG0624@2|Bacteria,1ZSV0@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Peptidase dimerisation domain	-	-	3.5.1.16	ko:K01438	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R00669,R09107	RC00064,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
SHD1_k127_5501660_4	234267.Acid_5496	4.499e-41	160.0	2C7E0@1|root,330TX@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_5501660_3	670292.JH26_02480	6.99e-57	210.0	COG0388@1|root,COG0388@2|Bacteria,1RC9F@1224|Proteobacteria,2UPC1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Carbon-nitrogen hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
SHD1_k127_5501660_0	1349767.GJA_4124	9.358e-183	596.0	COG3590@1|root,COG3590@2|Bacteria,1MVNQ@1224|Proteobacteria,2VMJF@28216|Betaproteobacteria,475K8@75682|Oxalobacteraceae	28216|Betaproteobacteria	O	Peptidase family M13	pepO	-	-	ko:K07386	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M13,Peptidase_M13_N
SHD1_k127_5501660_1	338969.Rfer_2523	3.799e-91	313.0	COG4977@1|root,COG4977@2|Bacteria,1MUDK@1224|Proteobacteria,2VHDN@28216|Betaproteobacteria,4ACFK@80864|Comamonadaceae	28216|Betaproteobacteria	K	SMART helix-turn-helix- domain containing protein, AraC type	-	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI,HTH_18
SHD1_k127_5501660_2	1210884.HG799463_gene9871	1.323e-78	273.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2IXZY@203682|Planctomycetes	203682|Planctomycetes	T	COG0515 Serine threonine protein	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_10,TPR_11,TPR_12,WD40
SHD1_k127_5503308_1	861299.J421_3916	2.086e-138	448.0	COG0618@1|root,COG0618@2|Bacteria,1ZSS0@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	DHH family	-	-	3.1.13.3,3.1.3.7	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
SHD1_k127_5503308_5	292459.STH1045	1.436e-06	53.0	COG0694@1|root,COG0694@2|Bacteria,1VAAU@1239|Firmicutes	1239|Firmicutes	O	Nitrogen fixation protein NifU	yutI	-	-	-	-	-	-	-	-	-	-	-	NifU
SHD1_k127_5503308_0	861299.J421_3915	1.565e-143	468.0	COG0489@1|root,COG0489@2|Bacteria,1ZSW7@142182|Gemmatimonadetes	142182|Gemmatimonadetes	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	-	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	FeS_assembly_P,ParA
SHD1_k127_5503308_2	861299.J421_3914	1.677e-137	457.0	COG0534@1|root,COG0534@2|Bacteria,1ZTFM@142182|Gemmatimonadetes	142182|Gemmatimonadetes	V	Polysaccharide biosynthesis C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MatE
SHD1_k127_5503308_4	861299.J421_3912	1.705e-90	310.0	COG1295@1|root,COG1295@2|Bacteria	2|Bacteria	S	lipopolysaccharide transmembrane transporter activity	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
SHD1_k127_5503308_3	234267.Acid_6584	7.793e-113	374.0	COG2321@1|root,COG2321@2|Bacteria,3Y3WQ@57723|Acidobacteria	57723|Acidobacteria	S	Putative neutral zinc metallopeptidase	-	-	-	ko:K07054	-	-	-	-	ko00000	-	-	-	Zn_peptidase
SHD1_k127_562817_2	1123242.JH636436_gene518	1.77e-06	59.0	COG0309@1|root,COG0309@2|Bacteria,2IX50@203682|Planctomycetes	203682|Planctomycetes	O	AIR synthase related protein, C-terminal domain	-	-	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
SHD1_k127_562817_0	1206744.BAGL01000128_gene6782	1.979e-160	514.0	COG0409@1|root,COG0409@2|Bacteria,2GMHA@201174|Actinobacteria,4FVKR@85025|Nocardiaceae	201174|Actinobacteria	O	Hydrogenase formation hypA family	hypD	-	-	ko:K04654	-	-	-	-	ko00000	-	-	-	HypD
SHD1_k127_562817_1	35754.JNYJ01000042_gene1380	1.987e-25	108.0	COG0298@1|root,COG0298@2|Bacteria,2IMSQ@201174|Actinobacteria,4DKQG@85008|Micromonosporales	201174|Actinobacteria	O	HupF/HypC family	-	-	-	ko:K04653	-	-	-	-	ko00000	-	-	-	HupF_HypC
SHD1_k127_580061_2	1077972.ARGLB_078_00930	2.569e-12	69.0	COG3214@1|root,COG3214@2|Bacteria,2GK0T@201174|Actinobacteria,1W9NJ@1268|Micrococcaceae	201174|Actinobacteria	S	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_42
SHD1_k127_580061_0	861299.J421_2040	8.363e-75	266.0	COG0639@1|root,COG0639@2|Bacteria,1ZUFY@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos_2
SHD1_k127_580061_1	234267.Acid_6479	3.95e-71	258.0	COG0577@1|root,COG0577@2|Bacteria,3Y3Z1@57723|Acidobacteria	234267.Acid_6479|-	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_580257_2	289376.THEYE_A1943	3.749e-74	257.0	COG1740@1|root,COG1740@2|Bacteria,3J0YW@40117|Nitrospirae	40117|Nitrospirae	C	NiFe/NiFeSe hydrogenase small subunit C-terminal	-	-	1.12.99.6	ko:K06282	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFe_hyd_SSU_C,Oxidored_q6
SHD1_k127_580257_1	383372.Rcas_3795	1.13e-118	392.0	COG0309@1|root,COG0309@2|Bacteria,2G5MV@200795|Chloroflexi,376G0@32061|Chloroflexia	32061|Chloroflexia	O	TIGRFAM hydrogenase expression formation protein HypE	-	-	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
SHD1_k127_580257_0	298653.Franean1_3401	5.093e-159	511.0	COG0409@1|root,COG0409@2|Bacteria,2GMHA@201174|Actinobacteria	201174|Actinobacteria	O	hydrogenase expression formation protein HypD	hypD	-	-	ko:K04654	-	-	-	-	ko00000	-	-	-	HypD
SHD1_k127_592298_1	861299.J421_3076	1.222e-53	194.0	COG0707@1|root,COG0707@2|Bacteria,1ZSW5@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
SHD1_k127_592298_0	861299.J421_3077	5.484e-170	550.0	COG0773@1|root,COG0773@2|Bacteria,1ZSQG@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
SHD1_k127_592298_2	861299.J421_3078	2.05e-39	161.0	COG1589@1|root,COG1589@2|Bacteria,1ZTRX@142182|Gemmatimonadetes	142182|Gemmatimonadetes	D	Cell division protein FtsQ	-	-	-	ko:K03589	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036	-	-	-	POTRA_1
SHD1_k127_601876_0	1209072.ALBT01000038_gene2369	4.809e-35	141.0	COG0811@1|root,COG0811@2|Bacteria,1PKF8@1224|Proteobacteria,1RRWP@1236|Gammaproteobacteria,1FFXF@10|Cellvibrio	1236|Gammaproteobacteria	U	MotA/TolQ/ExbB proton channel family	aglR	-	-	-	-	-	-	-	-	-	-	-	MotA_ExbB
SHD1_k127_601876_1	1121921.KB898716_gene26	1.952e-09	66.0	COG0848@1|root,COG0848@2|Bacteria,1RENY@1224|Proteobacteria,1S3TB@1236|Gammaproteobacteria,2PNP6@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	U	Biopolymer transport protein ExbD/TolR	-	-	-	-	-	-	-	-	-	-	-	-	ExbD
SHD1_k127_603387_0	861299.J421_5949	7.634e-109	382.0	COG0515@1|root,COG0515@2|Bacteria	861299.J421_5949|-	KLT	protein kinase activity	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	-
SHD1_k127_603387_1	1123073.KB899242_gene1301	6.28e-43	162.0	298RU@1|root,3059D@2|Bacteria,1QRA7@1224|Proteobacteria,1TDHB@1236|Gammaproteobacteria,1XAQM@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_616589_7	861299.J421_2677	0.0008789	47.0	COG4775@1|root,COG4775@2|Bacteria,1ZTG1@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_616589_5	204669.Acid345_1114	1.165e-61	220.0	COG0500@1|root,COG2226@2|Bacteria,3Y5WP@57723|Acidobacteria,2JNS6@204432|Acidobacteriia	204432|Acidobacteriia	Q	Mycolic acid cyclopropane synthetase	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_616589_4	861299.J421_2323	3.234e-88	317.0	COG0157@1|root,COG0157@2|Bacteria,1ZSR4@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Quinolinate phosphoribosyl transferase, C-terminal domain	-	-	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	-	QRPTase_C,QRPTase_N
SHD1_k127_616589_1	379066.GAU_0435	3.57e-139	457.0	COG0379@1|root,COG0379@2|Bacteria,1ZT10@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	-	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	-	NadA
SHD1_k127_616589_0	1379270.AUXF01000002_gene1767	3.355e-200	638.0	COG0029@1|root,COG0029@2|Bacteria,1ZT8U@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	-	-	1.4.3.16	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481	RC00006,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
SHD1_k127_616589_2	1380394.JADL01000012_gene974	5.668e-124	403.0	COG3483@1|root,COG3483@2|Bacteria,1MW68@1224|Proteobacteria,2TRXV@28211|Alphaproteobacteria,2JQCP@204441|Rhodospirillales	204441|Rhodospirillales	E	Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety	kynA	-	1.13.11.11	ko:K00453	ko00380,ko01100,map00380,map01100	M00038	R00678	RC00356	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_dioxygenase
SHD1_k127_616589_3	1380394.JADL01000012_gene975	7.464e-106	355.0	COG3844@1|root,COG3844@2|Bacteria,1MUKN@1224|Proteobacteria,2TR62@28211|Alphaproteobacteria,2JR6H@204441|Rhodospirillales	204441|Rhodospirillales	E	Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively	kynU	-	3.7.1.3	ko:K01556	ko00380,ko01100,map00380,map01100	M00038	R00987,R02668,R03936	RC00284,RC00415	ko00000,ko00001,ko00002,ko01000	-	-	-	Aminotran_5
SHD1_k127_618719_1	1382356.JQMP01000003_gene1584	4.969e-188	600.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,2G5QB@200795|Chloroflexi,27XKK@189775|Thermomicrobia	189775|Thermomicrobia	C	Succinyl-CoA ligase like flavodoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
SHD1_k127_618719_5	1121451.DESAM_21635	3.097e-31	125.0	2C82G@1|root,32RK9@2|Bacteria,1MZV5@1224|Proteobacteria,42U4W@68525|delta/epsilon subdivisions,2WQ9S@28221|Deltaproteobacteria,2MCV4@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF4242)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4242
SHD1_k127_618719_2	861299.J421_6291	3.224e-185	588.0	COG0004@1|root,COG0004@2|Bacteria,1ZT74@142182|Gemmatimonadetes	142182|Gemmatimonadetes	U	Ammonium Transporter Family	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
SHD1_k127_618719_3	861299.J421_6292	3.901e-56	200.0	COG0347@1|root,COG0347@2|Bacteria,1ZTTV@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Nitrogen regulatory protein P-II	-	-	-	ko:K04751	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
SHD1_k127_618719_4	379066.GAU_2847	3.329e-46	179.0	2ARQH@1|root,31H1J@2|Bacteria,1ZUJU@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Phosphodiester glycosidase	-	-	-	-	-	-	-	-	-	-	-	-	NAGPA
SHD1_k127_618719_0	379066.GAU_0244	0.0	1108.0	COG3968@1|root,COG3968@2|Bacteria,1ZSPJ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Glutamine synthetase type III N terminal	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	GSIII_N,Gln-synt_C
SHD1_k127_626500_0	861299.J421_2903	1.87e-146	475.0	COG0845@1|root,COG0845@2|Bacteria,1ZSX4@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	Biotin-lipoyl like	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	HlyD_D23
SHD1_k127_626500_1	861299.J421_2904	9.539e-64	226.0	COG1538@1|root,COG1538@2|Bacteria,1ZSMB@142182|Gemmatimonadetes	142182|Gemmatimonadetes	MU	Outer membrane efflux protein	-	-	-	ko:K12340	ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133	M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko02044	1.B.17,2.A.6.2	-	-	OEP
SHD1_k127_634424_2	861299.J421_2541	1.23e-85	288.0	COG4166@1|root,COG4166@2|Bacteria,1ZSMX@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
SHD1_k127_634424_0	861299.J421_2540	6.838e-146	467.0	COG0601@1|root,COG0601@2|Bacteria,1ZSXJ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	U	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
SHD1_k127_634424_5	1089544.KB912942_gene5324	2.159e-20	97.0	COG4758@1|root,COG4758@2|Bacteria,2I8FE@201174|Actinobacteria,4E31D@85010|Pseudonocardiales	201174|Actinobacteria	S	Cell wall-active antibiotics response 4TMS YvqF	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF1707,DUF2154
SHD1_k127_634424_4	682795.AciX8_0041	3.341e-35	140.0	COG2318@1|root,COG2318@2|Bacteria,3Y81K@57723|Acidobacteria,2JN5E@204432|Acidobacteriia	204432|Acidobacteriia	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
SHD1_k127_634424_3	670292.JH26_11125	4.052e-67	233.0	COG1028@1|root,COG1028@2|Bacteria,1RA3U@1224|Proteobacteria,2U640@28211|Alphaproteobacteria	28211|Alphaproteobacteria	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
SHD1_k127_634424_1	861299.J421_0680	4.153e-144	466.0	COG2072@1|root,COG2072@2|Bacteria,1ZV84@142182|Gemmatimonadetes	2|Bacteria	P	Flavin-binding monooxygenase-like	-	-	-	ko:K07222	-	-	-	-	ko00000	-	-	-	Pyr_redox_3
SHD1_k127_64931_1	1121472.AQWN01000015_gene1359	8.453e-15	78.0	COG0050@1|root,COG0050@2|Bacteria,1TPKC@1239|Firmicutes,2485I@186801|Clostridia,2602U@186807|Peptococcaceae	186801|Clostridia	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
SHD1_k127_64931_0	543728.Vapar_4918	1.599e-279	878.0	COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,2VI3Q@28216|Betaproteobacteria,4AAAN@80864|Comamonadaceae	28216|Betaproteobacteria	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
SHD1_k127_660458_1	1379270.AUXF01000002_gene1429	1.343e-108	359.0	COG0002@1|root,COG0002@2|Bacteria,1ZSV7@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	-	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
SHD1_k127_660458_2	379066.GAU_0158	1.053e-60	220.0	COG0548@1|root,COG0548@2|Bacteria,1ZTJI@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	-	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
SHD1_k127_660458_0	379066.GAU_0159	1.674e-147	482.0	COG4992@1|root,COG4992@2|Bacteria,1ZTEJ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Aminotransferase class-III	-	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
SHD1_k127_660458_3	861299.J421_1331	4.439e-28	121.0	COG1246@1|root,COG1246@2|Bacteria	2|Bacteria	E	Belongs to the acetyltransferase family. ArgA subfamily	argH	GO:0003674,GO:0003824,GO:0004042,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016043,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0022607,GO:0040007,GO:0042450,GO:0042802,GO:0042803,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046983,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.1,4.3.2.1	ko:K00619,ko:K14681	ko00220,ko00250,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map01100,map01110,map01130,map01210,map01230	M00028,M00029,M00844	R00259,R01086	RC00004,RC00064,RC00445,RC00447	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_0946	ASL_C2,Acetyltransf_1,Lyase_1
SHD1_k127_660458_4	379066.GAU_0150	6.245e-22	104.0	2FK3G@1|root,34BRK@2|Bacteria,1ZU1V@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Outer membrane protein beta-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl
SHD1_k127_660458_5	861299.J421_1299	1.237e-10	69.0	2FK3G@1|root,34BRK@2|Bacteria,1ZU1V@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Outer membrane protein beta-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl
SHD1_k127_668065_0	1085623.GNIT_3332	9.423e-79	282.0	COG1228@1|root,COG1228@2|Bacteria,1R6IT@1224|Proteobacteria,1SJV0@1236|Gammaproteobacteria,469BT@72275|Alteromonadaceae	1236|Gammaproteobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
SHD1_k127_668065_1	477228.YO5_18127	1.084e-56	225.0	COG3505@1|root,COG3505@2|Bacteria,1P1PZ@1224|Proteobacteria,1SRE4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	U	TraM recognition site of TraD and TraG	-	-	-	-	-	-	-	-	-	-	-	-	TraG-D_C
SHD1_k127_678706_0	1329516.JPST01000003_gene1164	9.367e-108	360.0	COG1840@1|root,COG1840@2|Bacteria,1TQC3@1239|Firmicutes,4HABY@91061|Bacilli,27CM5@186824|Thermoactinomycetaceae	91061|Bacilli	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6
SHD1_k127_678706_1	861299.J421_0063	1.157e-100	354.0	COG3842@1|root,COG3842@2|Bacteria,1ZU03@142182|Gemmatimonadetes	2|Bacteria	E	ABC transporter	-	-	3.6.3.30	ko:K02010	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10	-	-	ABC_tran,TOBE_2
SHD1_k127_678706_2	1145276.T479_00620	3.287e-36	144.0	COG1178@1|root,COG1178@2|Bacteria,1TPMX@1239|Firmicutes,4HCKW@91061|Bacilli,3IXJI@400634|Lysinibacillus	91061|Bacilli	U	permease	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
SHD1_k127_678842_1	861299.J421_3571	5.602e-197	621.0	COG0458@1|root,COG0458@2|Bacteria,1ZSPK@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Carbamoyl-phosphate synthetase large chain, oligomerisation domain	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
SHD1_k127_678842_2	861299.J421_3570	3.692e-166	542.0	COG0399@1|root,COG0399@2|Bacteria,1ZT81@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	DegT/DnrJ/EryC1/StrS aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
SHD1_k127_678842_4	1379698.RBG1_1C00001G1726	2.342e-14	87.0	29YZ1@1|root,30KVZ@2|Bacteria,2NRNQ@2323|unclassified Bacteria	2|Bacteria	S	Capsule assembly protein Wzi	-	-	-	-	-	-	-	-	-	-	-	-	Caps_assemb_Wzi
SHD1_k127_678842_0	861299.J421_0144	3.194e-209	658.0	COG1004@1|root,COG1004@2|Bacteria,1ZTH3@142182|Gemmatimonadetes	2|Bacteria	M	UDP binding domain	ugd	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
SHD1_k127_678842_3	861299.J421_0145	1.051e-160	513.0	COG0451@1|root,COG0451@2|Bacteria,1ZUJJ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	GM	3-beta hydroxysteroid dehydrogenase/isomerase family	-	-	4.1.1.35,4.2.1.46	ko:K01710,ko:K08678	ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00520,map00521,map00523,map00525,map01055,map01100,map01130	M00361,M00793	R01384,R06513	RC00402,RC00508	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
SHD1_k127_685341_3	861299.J421_3388	3.491e-26	108.0	COG0622@1|root,COG0622@2|Bacteria,1ZTPR@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	ko:K07095	-	-	-	-	ko00000	-	-	-	Metallophos_2
SHD1_k127_685341_1	379066.GAU_1752	2.747e-148	484.0	COG0019@1|root,COG0019@2|Bacteria,1ZT6G@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
SHD1_k127_685341_0	861299.J421_3390	2.723e-258	802.0	COG0442@1|root,COG0442@2|Bacteria,1ZT48@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro)	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,ProRS-C_1,tRNA-synt_2b
SHD1_k127_685341_2	861299.J421_3391	4.203e-118	388.0	COG0124@1|root,COG0124@2|Bacteria,1ZSXX@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Histidyl-tRNA synthetase	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_His
SHD1_k127_7157_4	861299.J421_3043	4.235e-55	203.0	COG0294@1|root,COG0294@2|Bacteria	2|Bacteria	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	folP	GO:0003674,GO:0003824,GO:0004156,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042221,GO:0042364,GO:0042398,GO:0042493,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0046655,GO:0046656,GO:0050896,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	1.13.11.81,2.5.1.15,2.7.6.3,4.1.2.25,5.1.99.8	ko:K00796,ko:K00950,ko:K01633	ko00790,ko01100,map00790,map01100	M00126,M00840,M00841	R03066,R03067,R03503,R03504,R11037,R11073	RC00002,RC00017,RC00121,RC00721,RC00842,RC00943,RC01479,RC03333,RC03334	ko00000,ko00001,ko00002,ko01000	-	-	iECO103_1326.ECO103_3924,iPC815.YPO3501	Pterin_bind
SHD1_k127_7157_0	861299.J421_3042	1.787e-301	937.0	COG0465@1|root,COG0465@2|Bacteria,1ZSRI@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,Peptidase_M41
SHD1_k127_7157_3	379066.GAU_1392	4.709e-76	258.0	COG0634@1|root,COG0634@2|Bacteria,1ZTH7@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Phosphoribosyl transferase domain	-	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
SHD1_k127_7157_2	861299.J421_3040	5.35e-98	336.0	COG0037@1|root,COG0037@2|Bacteria,1ZTK2@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3,TilS_C
SHD1_k127_7157_5	521045.Kole_1143	9.073e-55	199.0	COG1704@1|root,COG1704@2|Bacteria,2GCV5@200918|Thermotogae	200918|Thermotogae	S	LemA family	-	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
SHD1_k127_7157_6	1123307.KB904364_gene1213	1.119e-53	210.0	COG0501@1|root,COG0501@2|Bacteria,1TP23@1239|Firmicutes,4HB11@91061|Bacilli	91061|Bacilli	O	Belongs to the peptidase M48B family	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
SHD1_k127_7157_1	324602.Caur_1276	9.639e-110	360.0	COG0289@1|root,COG0289@2|Bacteria,2G7CZ@200795|Chloroflexi,376EK@32061|Chloroflexia	32061|Chloroflexia	E	PFAM Semialdehyde dehydrogenase NAD - binding	-	-	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_C,DapB_N
SHD1_k127_722876_3	1379270.AUXF01000003_gene3868	6.392e-56	212.0	2AEWX@1|root,314UJ@2|Bacteria,1ZUPP@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_722876_1	861299.J421_3591	2.83e-92	310.0	COG1028@1|root,COG1028@2|Bacteria,1ZTNC@142182|Gemmatimonadetes	142182|Gemmatimonadetes	IQ	KR domain	-	-	1.5.1.33	ko:K03793	-	-	-	-	ko00000,ko01000	-	-	-	adh_short_C2
SHD1_k127_722876_4	234267.Acid_4941	7.104e-29	122.0	COG1225@1|root,COG1225@2|Bacteria,3Y7Y4@57723|Acidobacteria	57723|Acidobacteria	O	Redoxin	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
SHD1_k127_722876_2	861299.J421_3592	1.578e-88	308.0	COG0613@1|root,COG0613@2|Bacteria,1ZTHM@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	DNA polymerase alpha chain like domain	-	-	3.1.3.97	ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	PHP
SHD1_k127_722876_5	1379270.AUXF01000003_gene3865	7.179e-20	91.0	2FHQX@1|root,349IG@2|Bacteria,1ZU2X@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_722876_6	379066.GAU_1992	8.354e-05	49.0	2AF2V@1|root,3151C@2|Bacteria,1ZVA0@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_722876_0	861299.J421_3595	2.469e-126	409.0	COG0508@1|root,COG0508@2|Bacteria,1ZT7I@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	2-oxoacid dehydrogenases acyltransferase (catalytic domain)	-	-	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
SHD1_k127_725074_2	379066.GAU_3007	2.713e-55	197.0	COG1012@1|root,COG1012@2|Bacteria,1ZT7A@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Aldehyde dehydrogenase family	-	-	-	ko:K00138	ko00010,ko00620,ko01100,ko01110,ko01120,map00010,map00620,map01100,map01110,map01120	-	R00711	RC00047	ko00000,ko00001,ko01000	-	-	-	Aldedh
SHD1_k127_725074_0	1035308.AQYY01000002_gene1056	4.444e-102	348.0	2DB7V@1|root,2Z7NX@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_725074_1	861299.J421_3723	1.906e-92	323.0	COG0457@1|root,COG2206@1|root,COG0457@2|Bacteria,COG2206@2|Bacteria	2|Bacteria	T	PFAM metal-dependent phosphohydrolase, HD sub domain	-	-	-	-	-	-	-	-	-	-	-	-	CHASE6_C,DICT,GerE,HD,HD_5
SHD1_k127_725938_3	983920.Y88_1773	2.684e-133	438.0	COG2271@1|root,COG2271@2|Bacteria,1MUEK@1224|Proteobacteria,2TS60@28211|Alphaproteobacteria,2K32T@204457|Sphingomonadales	204457|Sphingomonadales	G	Major Facilitator	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SHD1_k127_725938_5	861299.J421_2878	4.125e-95	320.0	COG1295@1|root,COG1295@2|Bacteria,1ZTHX@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Virulence factor BrkB	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
SHD1_k127_725938_6	861299.J421_2877	8.135e-34	139.0	COG4980@1|root,COG4980@2|Bacteria,1ZU46@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	YtxH-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YtxH
SHD1_k127_725938_1	861299.J421_2876	1.326e-174	561.0	COG2204@1|root,COG2204@2|Bacteria,1ZSW0@142182|Gemmatimonadetes	2|Bacteria	T	Sigma-54 interaction domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
SHD1_k127_725938_0	379066.GAU_1107	3.466e-193	614.0	COG0191@1|root,COG0191@2|Bacteria,1ZSZE@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	Fructose-bisphosphate aldolase class-II	-	-	-	-	-	-	-	-	-	-	-	-	F_bP_aldolase
SHD1_k127_725938_4	861299.J421_2872	3.319e-103	350.0	COG1235@1|root,COG1235@2|Bacteria,1ZT49@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Metallo-beta-lactamase superfamily	-	-	3.1.4.55	ko:K06167	ko00440,map00440	-	R10205	RC00296	ko00000,ko00001,ko01000	-	-	-	Lactamase_B_2
SHD1_k127_725938_2	861299.J421_2871	1.643e-157	505.0	COG0469@1|root,COG0469@2|Bacteria,1ZSMD@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	Pyruvate kinase, barrel domain	-	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
SHD1_k127_728909_2	861299.J421_0507	1.689e-85	293.0	COG0667@1|root,COG0667@2|Bacteria	2|Bacteria	C	Aldo Keto reductase	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	Aldo_ket_red
SHD1_k127_728909_0	861299.J421_0506	1.777e-257	811.0	COG0308@1|root,COG0308@2|Bacteria,1ZUT0@142182|Gemmatimonadetes	2|Bacteria	E	Peptidase family M1 domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1
SHD1_k127_728909_1	861299.J421_0504	2.786e-137	439.0	COG1398@1|root,COG1398@2|Bacteria,1ZT9N@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Fatty acid desaturase	-	-	1.14.19.1	ko:K00507	ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212	-	R02222	RC00917	ko00000,ko00001,ko01000,ko01004	-	-	-	-
SHD1_k127_736541_0	379066.GAU_1789	2.762e-275	850.0	COG0539@1|root,COG2183@1|root,COG0539@2|Bacteria,COG2183@2|Bacteria,1ZSKI@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	-	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
SHD1_k127_736541_2	452637.Oter_3517	3.885e-64	238.0	COG0793@1|root,COG0793@2|Bacteria	2|Bacteria	M	Belongs to the peptidase S41A family	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_S41
SHD1_k127_736541_5	1229205.BUPH_05587	6.551e-16	82.0	2EM7X@1|root,33EX1@2|Bacteria,1P553@1224|Proteobacteria,2W726@28216|Betaproteobacteria,1KDK9@119060|Burkholderiaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_736541_4	497965.Cyan7822_0541	1.801e-18	98.0	COG1873@1|root,COG1873@2|Bacteria,1GEUB@1117|Cyanobacteria	1117|Cyanobacteria	S	PFAM PRC-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_736541_1	63737.Npun_R0136	3.874e-153	496.0	COG1914@1|root,COG1914@2|Bacteria,1G91I@1117|Cyanobacteria	1117|Cyanobacteria	P	PFAM natural resistance-associated macrophage protein	-	-	-	-	-	-	-	-	-	-	-	-	Nramp
SHD1_k127_736541_3	394221.Mmar10_1754	8.686e-22	96.0	COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2TRI1@28211|Alphaproteobacteria,43W7R@69657|Hyphomonadaceae	28211|Alphaproteobacteria	I	COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)	pccB	-	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
SHD1_k127_748096_1	1379270.AUXF01000006_gene35	1.985e-175	559.0	COG2805@1|root,COG2805@2|Bacteria,1ZU8X@142182|Gemmatimonadetes	142182|Gemmatimonadetes	NU	Type II/IV secretion system protein	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
SHD1_k127_748096_3	861299.J421_3534	7.291e-65	226.0	COG0511@1|root,COG0511@2|Bacteria,1ZTR1@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA	-	-	-	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742	RC00040,RC00367	ko00000,ko00001,ko00002	-	-	-	Biotin_lipoyl
SHD1_k127_748096_2	861299.J421_3535	9.473e-157	505.0	COG0006@1|root,COG0006@2|Bacteria,1ZSTY@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Creatinase/Prolidase N-terminal domain	-	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
SHD1_k127_748096_4	379066.GAU_1927	9.106e-46	179.0	COG0757@1|root,COG0757@2|Bacteria,1ZTVT@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Catalyzes a trans-dehydration via an enolate intermediate	aroQ	-	4.2.1.10	ko:K03786	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_II
SHD1_k127_748096_5	379066.GAU_1928	1.116e-39	168.0	COG0457@1|root,COG0457@2|Bacteria,1ZTTU@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
SHD1_k127_748096_0	861299.J421_3538	2.044e-196	630.0	COG0760@1|root,COG0760@2|Bacteria,1ZTD1@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	SurA N-terminal domain	-	-	5.2.1.8	ko:K03770	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase_2,SurA_N_2
SHD1_k127_760004_5	861299.J421_6214	6.958e-29	118.0	2DNAS@1|root,32WH6@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Phi_1
SHD1_k127_760004_2	379066.GAU_0398	1.047e-155	513.0	COG0624@1|root,COG0624@2|Bacteria,1ZSMA@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
SHD1_k127_760004_4	373994.Riv7116_4482	2.287e-38	149.0	COG0251@1|root,COG0251@2|Bacteria,1G6TD@1117|Cyanobacteria,1HK8V@1161|Nostocales	1117|Cyanobacteria	J	TIGRFAM endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
SHD1_k127_760004_1	1128421.JAGA01000002_gene816	2.219e-182	587.0	COG1233@1|root,COG1233@2|Bacteria,2NQAT@2323|unclassified Bacteria	2|Bacteria	Q	Flavin containing amine oxidoreductase	pys	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
SHD1_k127_760004_6	1144275.COCOR_05299	2.658e-13	78.0	COG1546@1|root,COG1546@2|Bacteria,1P6VQ@1224|Proteobacteria,4333J@68525|delta/epsilon subdivisions,2WYBU@28221|Deltaproteobacteria,2Z151@29|Myxococcales	28221|Deltaproteobacteria	S	Belongs to the CinA family	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_760004_3	861299.J421_2236	1.087e-131	428.0	COG0395@1|root,COG0395@2|Bacteria,1ZSV5@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	Inward rectifier potassium channel	-	-	-	ko:K08715	-	-	-	-	ko00000,ko02000	1.A.2.2	-	-	IRK
SHD1_k127_760004_0	861299.J421_2235	7.748e-201	639.0	COG0025@1|root,COG0025@2|Bacteria,1ZT1K@142182|Gemmatimonadetes	142182|Gemmatimonadetes	P	Sodium/hydrogen exchanger family	-	-	-	ko:K03316	-	-	-	-	ko00000	2.A.36	-	-	Na_H_Exchanger
SHD1_k127_770076_7	1379270.AUXF01000006_gene133	1.596e-26	109.0	COG1077@1|root,COG1077@2|Bacteria,1ZT9B@142182|Gemmatimonadetes	142182|Gemmatimonadetes	D	Hsp70 protein	-	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
SHD1_k127_770076_4	379066.GAU_1760	9.642e-77	269.0	COG1792@1|root,COG1792@2|Bacteria,1ZSYE@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	rod shape-determining protein MreC	-	-	-	ko:K03570	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreC
SHD1_k127_770076_5	861299.J421_3396	3.712e-50	183.0	2CIX2@1|root,33ZZP@2|Bacteria,1ZTZK@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	rod shape-determining protein MreD	-	-	-	ko:K03571	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreD
SHD1_k127_770076_0	861299.J421_3395	4.086e-228	723.0	COG0768@1|root,COG0768@2|Bacteria,1ZSX5@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	Penicillin-binding Protein dimerisation domain	-	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
SHD1_k127_770076_1	861299.J421_3394	5e-173	560.0	COG0772@1|root,COG0772@2|Bacteria,1ZSXM@142182|Gemmatimonadetes	142182|Gemmatimonadetes	D	Cell cycle protein	-	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
SHD1_k127_770076_2	379066.GAU_1756	2.345e-142	456.0	COG0777@1|root,COG0777@2|Bacteria,1ZSSK@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA	accD	-	2.1.3.15,6.4.1.2	ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
SHD1_k127_770076_3	379066.GAU_1755	4.75e-131	432.0	COG0285@1|root,COG0285@2|Bacteria,1ZSRP@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Mur ligase middle domain	-	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_M
SHD1_k127_770076_6	1379270.AUXF01000006_gene140	1.47e-35	136.0	COG0124@1|root,COG0124@2|Bacteria,1ZSXX@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Histidyl-tRNA synthetase	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_His
SHD1_k127_783252_6	861299.J421_4119	2.583e-76	261.0	COG0534@1|root,COG0534@2|Bacteria,1ZT8D@142182|Gemmatimonadetes	142182|Gemmatimonadetes	V	MatE	-	-	-	-	-	-	-	-	-	-	-	-	MatE
SHD1_k127_783252_2	485913.Krac_1887	1.971e-148	482.0	COG1680@1|root,COG1680@2|Bacteria,2G6IE@200795|Chloroflexi	200795|Chloroflexi	V	PFAM Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
SHD1_k127_783252_9	1144319.PMI16_02809	3.546e-40	157.0	COG3832@1|root,COG3832@2|Bacteria,1RI7Y@1224|Proteobacteria,2VW09@28216|Betaproteobacteria	28216|Betaproteobacteria	O	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
SHD1_k127_783252_8	1122604.JONR01000008_gene2237	1.262e-45	167.0	COG0640@1|root,COG0640@2|Bacteria,1RH5P@1224|Proteobacteria,1S9NT@1236|Gammaproteobacteria,1X7N9@135614|Xanthomonadales	135614|Xanthomonadales	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
SHD1_k127_783252_0	426117.M446_6558	6.766e-283	899.0	COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,2TR6F@28211|Alphaproteobacteria,1JSF2@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle	ppc	-	4.1.1.31	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00168,M00170,M00171,M00172,M00173,M00346,M00374	R00345	RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPcase
SHD1_k127_783252_5	266834.SMc01943	1.824e-116	387.0	COG1052@1|root,COG1052@2|Bacteria,1MU2D@1224|Proteobacteria,2TSM8@28211|Alphaproteobacteria,4B80B@82115|Rhizobiaceae	28211|Alphaproteobacteria	CH	D-isomer specific 2-hydroxyacid dehydrogenase	gyaR	-	1.1.1.215,1.1.1.26,1.1.1.79,1.1.1.81	ko:K00015,ko:K00050,ko:K00090	ko00030,ko00260,ko00620,ko00630,ko01100,ko01110,ko01120,map00030,map00260,map00620,map00630,map01100,map01110,map01120	-	R00465,R00717,R01388,R01392,R01739	RC00031,RC00042,RC00084	ko00000,ko00001,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
SHD1_k127_783252_4	420662.Mpe_A3256	3.793e-136	448.0	COG0074@1|root,COG0074@2|Bacteria,1MUGA@1224|Proteobacteria,2VH1U@28216|Betaproteobacteria,1KJK8@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5,6.2.1.9	ko:K01902,ko:K08692	ko00020,ko00630,ko00640,ko00660,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00630,map00640,map00660,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00346,M00374,M00620	R00405,R01256,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA
SHD1_k127_783252_1	426117.M446_6556	6.371e-174	554.0	COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,2TRXK@28211|Alphaproteobacteria,1JSG6@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	mtkA	-	6.2.1.5,6.2.1.9	ko:K01903,ko:K14067	ko00020,ko00630,ko00640,ko00660,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00630,map00640,map00660,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00346,M00374,M00620	R00405,R01256,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
SHD1_k127_783252_3	935548.KI912159_gene1181	1.268e-137	453.0	COG2301@1|root,COG2301@2|Bacteria,1MW0A@1224|Proteobacteria,2TU4H@28211|Alphaproteobacteria,43NKE@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	Belongs to the HpcH HpaI aldolase family	-	-	4.1.3.34	ko:K01644	ko02020,map02020	-	R00362	RC00067,RC01118	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
SHD1_k127_783252_7	391165.GbCGDNIH1_0048	6.545e-70	241.0	COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,2TQSN@28211|Alphaproteobacteria,2JQ78@204441|Rhodospirillales	204441|Rhodospirillales	E	Aminotransferase class-V	-	-	2.6.1.44,2.6.1.45,2.6.1.51	ko:K00830	ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146	M00346,M00532	R00369,R00372,R00585,R00588	RC00006,RC00008,RC00018	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
SHD1_k127_803926_0	926560.KE387023_gene2884	1.719e-57	202.0	COG2318@1|root,COG2318@2|Bacteria,1WMM8@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Mycothiol maleylpyruvate isomerase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
SHD1_k127_803926_2	390989.JOEG01000003_gene4696	4.443e-08	58.0	2DR0Y@1|root,339QH@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF4235)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4235
SHD1_k127_803926_1	1267535.KB906767_gene2105	4.392e-43	164.0	COG0607@1|root,COG0607@2|Bacteria,3Y5RG@57723|Acidobacteria,2JNKJ@204432|Acidobacteriia	204432|Acidobacteriia	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
SHD1_k127_803926_3	1146883.BLASA_3638	7.102e-07	58.0	COG0798@1|root,COG0798@2|Bacteria,2GJ4H@201174|Actinobacteria	201174|Actinobacteria	P	arsenical-resistance protein	arsB	-	1.20.4.1	ko:K03325,ko:K03741	-	-	-	-	ko00000,ko01000,ko02000	2.A.59	-	-	SBF
SHD1_k127_806984_1	861299.J421_3527	3.107e-185	584.0	COG0468@1|root,COG0468@2|Bacteria,1ZT78@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	-	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
SHD1_k127_806984_2	861299.J421_3526	1.5e-42	165.0	COG2137@1|root,COG2137@2|Bacteria,1ZU56@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Modulates RecA activity	recX	-	-	ko:K03565	-	-	-	-	ko00000,ko03400	-	-	-	RecX
SHD1_k127_806984_0	379066.GAU_1915	1.11e-192	611.0	COG0013@1|root,COG0013@2|Bacteria,1ZT18@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
SHD1_k127_821367_1	1379270.AUXF01000006_gene221	6.168e-30	119.0	COG0039@1|root,COG0039@2|Bacteria,1ZSV3@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	-	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
SHD1_k127_821367_0	1379270.AUXF01000006_gene220	2.886e-148	478.0	COG2896@1|root,COG2896@2|Bacteria,1ZSMN@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Mob_synth_C,Radical_SAM
SHD1_k127_821367_2	1379270.AUXF01000006_gene219	2.858e-22	98.0	COG0314@1|root,COG0314@2|Bacteria,1ZU08@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	MoaE protein	-	-	2.8.1.12	ko:K03635	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoaE
SHD1_k127_824493_4	379066.GAU_1525	6.05e-102	340.0	COG1721@1|root,COG1721@2|Bacteria,1ZSKR@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
SHD1_k127_824493_2	861299.J421_3150	9.718e-159	512.0	COG0714@1|root,COG0714@2|Bacteria,1ZT94@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
SHD1_k127_824493_6	861299.J421_3149	1.99e-85	295.0	COG1187@1|root,COG1187@2|Bacteria,1ZT5B@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	S4 RNA-binding domain	-	-	5.4.99.22	ko:K06178	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
SHD1_k127_824493_9	1396418.BATQ01000141_gene3395	6.556e-33	136.0	COG1386@1|root,COG1386@2|Bacteria,46VRU@74201|Verrucomicrobia,2IUTS@203494|Verrucomicrobiae	203494|Verrucomicrobiae	K	Segregation and condensation complex subunit ScpB	-	-	-	-	-	-	-	-	-	-	-	-	SMC_ScpB
SHD1_k127_824493_5	1379270.AUXF01000005_gene775	3.927e-89	300.0	COG1354@1|root,COG1354@2|Bacteria,1ZT1G@142182|Gemmatimonadetes	142182|Gemmatimonadetes	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	-	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
SHD1_k127_824493_11	861299.J421_3145	3.183e-18	87.0	COG0268@1|root,COG0268@2|Bacteria,1ZU6B@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Binds directly to 16S ribosomal RNA	rpsT	-	-	ko:K02968	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S20p
SHD1_k127_824493_10	861299.J421_3144	6.997e-28	126.0	COG1196@1|root,COG1196@2|Bacteria,1ZU4J@142182|Gemmatimonadetes	142182|Gemmatimonadetes	D	Zinc finger domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_824493_0	861299.J421_3143	9.171e-207	658.0	COG0044@1|root,COG0044@2|Bacteria,1ZT4U@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	pyrC	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
SHD1_k127_824493_1	861299.J421_3142	6.392e-175	554.0	COG0540@1|root,COG0540@2|Bacteria,1ZSN7@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain	pyrB	-	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
SHD1_k127_824493_7	1379270.AUXF01000005_gene769	1.317e-76	274.0	COG2065@1|root,COG2065@2|Bacteria,1ZTHG@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant	pyrR	-	2.4.2.9	ko:K02825	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000,ko03000	-	-	-	Pribosyltran
SHD1_k127_824493_8	1408418.JNJH01000022_gene1773	1.347e-33	137.0	COG0586@1|root,COG0586@2|Bacteria,1MX4M@1224|Proteobacteria,2U7G6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	PFAM SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
SHD1_k127_824493_3	642227.HA49_17415	1.591e-137	450.0	COG2042@1|root,COG3376@2|Bacteria,1MUYH@1224|Proteobacteria,1RQM1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	U	Belongs to the NiCoT transporter (TC 2.A.52) family	hoxN	-	-	ko:K07241	-	-	-	-	ko00000,ko02000	2.A.52.1	-	-	NicO
SHD1_k127_824493_12	981369.JQMJ01000003_gene7270	1.512e-05	48.0	COG1853@1|root,COG1853@2|Bacteria,2I8FY@201174|Actinobacteria,2NJ7P@228398|Streptacidiphilus	201174|Actinobacteria	S	Flavin reductase like domain	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
SHD1_k127_851536_1	1379270.AUXF01000002_gene1475	4.967e-58	231.0	COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,1ZTAG@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA
SHD1_k127_851536_0	925409.KI911562_gene2451	2.815e-199	648.0	COG4772@1|root,COG4772@2|Bacteria,4NH5V@976|Bacteroidetes,1IV3Y@117747|Sphingobacteriia	976|Bacteroidetes	P	TonB dependent receptor	-	-	-	ko:K16091	-	-	-	-	ko00000,ko02000	1.B.14.1.14	-	-	CarbopepD_reg_2,Plug,TonB_dep_Rec
SHD1_k127_860422_0	861299.J421_1793	1.219e-285	890.0	COG4993@1|root,COG4993@2|Bacteria	2|Bacteria	G	Dehydrogenase	-	-	1.1.2.8	ko:K00114	ko00010,ko00625,ko01100,ko01110,ko01120,ko01130,map00010,map00625,map01100,map01110,map01120,map01130	-	R05062,R05198,R05285	RC00087,RC00088,RC01039	ko00000,ko00001,ko01000	-	-	-	PQQ,PQQ_2
SHD1_k127_860422_5	1267535.KB906767_gene4140	2.257e-35	141.0	COG2010@1|root,COG2010@2|Bacteria,3Y7WV@57723|Acidobacteria	57723|Acidobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	ko:K00406	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	Cytochrome_CBB3
SHD1_k127_860422_2	861299.J421_1791	1.111e-95	330.0	COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,1ZT3S@142182|Gemmatimonadetes	2|Bacteria	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	ctaC	GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:1901135,GO:1901360,GO:1901564	1.9.3.1	ko:K02275,ko:K17223	ko00190,ko00920,ko01100,ko01120,map00190,map00920,map01100,map01120	M00155,M00595	R00081,R10151	RC00016,RC03151,RC03152	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM,Cytochrom_C,Cytochrome_CBB3
SHD1_k127_860422_1	1028801.RG1141_CH19030	2.119e-260	824.0	COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,2TQP1@28211|Alphaproteobacteria,4BCZ3@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	ctaD	-	1.9.3.1	ko:K02274,ko:K15408	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
SHD1_k127_860422_4	861299.J421_1789	8.713e-40	161.0	COG1845@1|root,COG1845@2|Bacteria	2|Bacteria	C	cytochrome c oxidase, subunit III	-	-	1.9.3.1	ko:K02274,ko:K02276,ko:K15408	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1,COX3
SHD1_k127_860422_3	1095769.CAHF01000010_gene1357	6.694e-94	321.0	COG4221@1|root,COG4221@2|Bacteria,1MUU6@1224|Proteobacteria,2VM6H@28216|Betaproteobacteria,475PA@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
SHD1_k127_860422_7	1218084.BBJK01000014_gene1503	0.0002141	51.0	28XAU@1|root,2ZJ8T@2|Bacteria,1PBIU@1224|Proteobacteria,2W6AX@28216|Betaproteobacteria,1K8VW@119060|Burkholderiaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_860422_6	861299.J421_3812	3.196e-25	106.0	COG0296@1|root,COG0296@2|Bacteria,1ZT8Y@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
SHD1_k127_867018_6	861299.J421_3552	1.183e-08	61.0	COG0810@1|root,COG0810@2|Bacteria,1ZTWX@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	TonB C terminal	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_2
SHD1_k127_867018_3	861299.J421_3553	2.531e-49	179.0	COG0848@1|root,COG0848@2|Bacteria,1ZTRS@142182|Gemmatimonadetes	142182|Gemmatimonadetes	U	Biopolymer transport protein ExbD/TolR	-	-	-	ko:K03559,ko:K03560	-	-	-	-	ko00000,ko02000	1.A.30.2.1,1.A.30.2.2	-	-	ExbD
SHD1_k127_867018_2	861299.J421_3554	4.217e-77	274.0	COG0811@1|root,COG0811@2|Bacteria,1ZTBF@142182|Gemmatimonadetes	142182|Gemmatimonadetes	U	MotA/TolQ/ExbB proton channel family	-	-	-	ko:K03562	ko01120,map01120	-	-	-	ko00000,ko02000	1.A.30.2.2	-	-	MotA_ExbB
SHD1_k127_867018_0	379066.GAU_1946	1.419e-127	416.0	COG1087@1|root,COG1087@2|Bacteria,1ZSX3@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	3-beta hydroxysteroid dehydrogenase/isomerase family	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
SHD1_k127_867018_1	644966.Tmar_1263	1.887e-91	316.0	COG0373@1|root,COG0373@2|Bacteria,1TQN9@1239|Firmicutes,2496M@186801|Clostridia,3WDC1@538999|Clostridiales incertae sedis	186801|Clostridia	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	-	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
SHD1_k127_867018_4	1380763.BG53_15955	3.644e-23	110.0	COG1648@1|root,COG1648@2|Bacteria,1VA2E@1239|Firmicutes,4HIRG@91061|Bacilli,26VIW@186822|Paenibacillaceae	91061|Bacilli	H	Siroheme synthase	sirC	-	1.3.1.76,4.99.1.4	ko:K02304	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03947	RC01012,RC01034	ko00000,ko00001,ko00002,ko01000	-	-	-	NAD_binding_7,Sirohm_synth_M
SHD1_k127_867018_5	177439.DP3080	5.13e-15	81.0	COG0755@1|root,COG0755@2|Bacteria,1RCCI@1224|Proteobacteria,42PVM@68525|delta/epsilon subdivisions,2WJ7I@28221|Deltaproteobacteria,2MHT7@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Cytochrome c assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
SHD1_k127_881_7	1356852.N008_19570	3.182e-29	124.0	COG0628@1|root,COG0628@2|Bacteria,4NIB3@976|Bacteroidetes,47P40@768503|Cytophagia	976|Bacteroidetes	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
SHD1_k127_881_4	861299.J421_4120	8.442e-63	224.0	COG3544@1|root,COG3544@2|Bacteria,1ZTPN@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Domain of unknown function (DUF305)	-	-	-	-	-	-	-	-	-	-	-	-	DUF305
SHD1_k127_881_1	861299.J421_4121	2.965e-287	898.0	COG5276@1|root,COG5276@2|Bacteria,1ZTC3@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	LVIVD repeat	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
SHD1_k127_881_8	258594.RPA3594	2.605e-28	120.0	COG5552@1|root,COG5552@2|Bacteria,1MZBV@1224|Proteobacteria,2UC5C@28211|Alphaproteobacteria,3JZF4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Uncharacterized conserved protein (DUF2277)	MA20_01405	-	-	-	-	-	-	-	-	-	-	-	DUF2277
SHD1_k127_881_6	1150398.JIBJ01000011_gene2289	5.099e-32	130.0	COG0346@1|root,COG0346@2|Bacteria,2IRQX@201174|Actinobacteria	201174|Actinobacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
SHD1_k127_881_2	1379270.AUXF01000003_gene3637	7.982e-259	812.0	COG0488@1|root,COG0488@2|Bacteria,1ZSQT@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	ABC transporter C-terminal domain	-	-	-	ko:K15738	-	-	-	-	ko00000,ko02000	3.A.1.120.6	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
SHD1_k127_881_3	861299.J421_0892	1.034e-180	578.0	COG0076@1|root,COG0076@2|Bacteria,1ZTFP@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Pyridoxal-dependent decarboxylase conserved domain	-	-	4.1.1.86	ko:K13745	ko00260,ko01120,map00260,map01120	-	R07650	RC00299	ko00000,ko00001,ko01000	-	-	-	Pyridoxal_deC
SHD1_k127_881_12	861299.J421_0091	6.694e-23	104.0	28XFN@1|root,2ZJD7@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_881_5	525904.Tter_2724	6.336e-37	143.0	COG3439@1|root,COG3439@2|Bacteria,2NPV1@2323|unclassified Bacteria	2|Bacteria	S	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	DUF302
SHD1_k127_881_9	459495.SPLC1_S410120	3.884e-25	108.0	COG0640@1|root,COG0640@2|Bacteria,1G6V5@1117|Cyanobacteria,1HBKV@1150|Oscillatoriales	1117|Cyanobacteria	K	PFAM Bacterial regulatory protein, arsR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5
SHD1_k127_881_11	1379270.AUXF01000001_gene2733	1.592e-23	101.0	29X7I@1|root,30IWS@2|Bacteria,1ZV88@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Protein of unknown function (DUF2892)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2892
SHD1_k127_881_0	1379270.AUXF01000001_gene2734	0.0	1540.0	COG0841@1|root,COG0841@2|Bacteria,1ZUDY@142182|Gemmatimonadetes	142182|Gemmatimonadetes	V	Protein export membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
SHD1_k127_881_10	1379270.AUXF01000001_gene2735	5.637e-24	104.0	COG0845@1|root,COG0845@2|Bacteria,1ZU91@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	Biotin-lipoyl like	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
SHD1_k127_885407_4	1379270.AUXF01000001_gene2184	2.236e-31	136.0	COG0859@1|root,COG0859@2|Bacteria	2|Bacteria	M	ADP-heptose-lipopolysaccharide heptosyltransferase activity	-	-	-	ko:K02849,ko:K12982	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
SHD1_k127_885407_0	861299.J421_0292	2.546e-244	769.0	COG0038@1|root,COG0517@1|root,COG0038@2|Bacteria,COG0517@2|Bacteria	2|Bacteria	S	IMP dehydrogenase activity	clcA_1	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	-	CBS,Voltage_CLC
SHD1_k127_885407_2	379066.GAU_2027	1.284e-40	166.0	COG1802@1|root,COG1802@2|Bacteria,1ZUBC@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
SHD1_k127_885407_1	1267533.KB906735_gene4544	2.445e-179	568.0	COG0031@1|root,COG0031@2|Bacteria,3Y45Z@57723|Acidobacteria,2JKHG@204432|Acidobacteriia	204432|Acidobacteriia	E	Pyridoxal-phosphate dependent enzyme	-	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
SHD1_k127_885407_3	1267534.KB906757_gene846	1.037e-38	145.0	COG3503@1|root,COG3503@2|Bacteria,3Y3XK@57723|Acidobacteria,2JM1Q@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein of unknown function (DUF1624)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1624
SHD1_k127_894480_0	1242864.D187_002422	1.661e-235	753.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,42MW3@68525|delta/epsilon subdivisions,2WJRZ@28221|Deltaproteobacteria,2YW7G@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	ppsA	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2101	PEP-utilizers,PEP-utilizers_C,PPDK_N
SHD1_k127_8958_1	204669.Acid345_2325	1.069e-72	250.0	COG0673@1|root,COG0673@2|Bacteria,3Y3V4@57723|Acidobacteria,2JI4A@204432|Acidobacteriia	204432|Acidobacteriia	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
SHD1_k127_8958_4	497964.CfE428DRAFT_0285	1.587e-05	49.0	COG0393@1|root,COG0393@2|Bacteria,46WT4@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Putative heavy-metal-binding	-	-	-	-	-	-	-	-	-	-	-	-	YbjQ_1
SHD1_k127_8958_2	1379270.AUXF01000005_gene543	2.101e-50	190.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
SHD1_k127_8958_3	861299.J421_1164	1.669e-13	80.0	COG2968@1|root,COG2968@2|Bacteria,1ZTTR@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Protein of unknown function (DUF541)	-	-	-	ko:K09807	-	-	-	-	ko00000	-	-	-	SIMPL
SHD1_k127_8958_0	861299.J421_5977	3.789e-91	310.0	COG0665@1|root,COG0665@2|Bacteria,1ZUQF@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
SHD1_k127_898306_5	526225.Gobs_2454	1.647e-56	201.0	COG5424@1|root,COG5424@2|Bacteria,2I9SS@201174|Actinobacteria	201174|Actinobacteria	H	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ	pqqC	-	1.3.3.11	ko:K06137	-	-	-	-	ko00000,ko01000	-	-	-	TENA_THI-4
SHD1_k127_898306_3	994479.GL877878_gene3444	2.775e-70	250.0	COG1235@1|root,COG1235@2|Bacteria,2HBMA@201174|Actinobacteria,4DZUU@85010|Pseudonocardiales	201174|Actinobacteria	S	May be involved in the transport of PQQ or its precursor to the periplasm	pqqB	-	-	ko:K06136	-	-	-	-	ko00000	-	-	-	Lactamase_B_2
SHD1_k127_898306_1	671143.DAMO_2793	3.854e-104	346.0	COG2204@1|root,COG2204@2|Bacteria,2NNPN@2323|unclassified Bacteria	2|Bacteria	T	COGs COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains	atoC	-	-	ko:K02481,ko:K07714	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
SHD1_k127_898306_2	671143.DAMO_2793	1.082e-70	246.0	COG2204@1|root,COG2204@2|Bacteria,2NNPN@2323|unclassified Bacteria	2|Bacteria	T	COGs COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains	atoC	-	-	ko:K02481,ko:K07714	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
SHD1_k127_898306_0	671143.DAMO_2794	1.368e-150	493.0	COG2770@1|root,COG4191@1|root,COG2770@2|Bacteria,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	icfG	-	2.7.13.3,3.1.3.3,4.6.1.1	ko:K01768,ko:K02482,ko:K02660,ko:K03406,ko:K05874,ko:K07315,ko:K10819,ko:K11525,ko:K11617	ko00230,ko02020,ko02025,ko02030,ko04113,ko04213,map00230,map02020,map02025,map02030,map04113,map04213	M00481,M00695,M00754	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035,ko02044,ko03021	-	-	-	EAL,GGDEF,Guanylate_cyc,HAMP,HATPase_c,HisKA,MCPsignal,SpoIIE,dCache_1
SHD1_k127_898306_4	1122221.JHVI01000041_gene2464	2.138e-62	226.0	COG1125@1|root,COG1125@2|Bacteria,1WJN3@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	COGs COG1125 ABC-type proline glycine betaine transport systems ATPase components	-	-	-	ko:K05847	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	ABC_tran,CBS
SHD1_k127_898306_6	311403.Arad_8392	6.074e-37	149.0	COG1732@1|root,COG1732@2|Bacteria,1MV9N@1224|Proteobacteria,2TTY6@28211|Alphaproteobacteria,4B8P8@82115|Rhizobiaceae	28211|Alphaproteobacteria	M	Substrate binding domain of ABC-type glycine betaine transport system	-	-	-	ko:K05845	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	OpuAC
SHD1_k127_905450_1	379066.GAU_2889	4.171e-51	185.0	COG2060@1|root,COG2060@2|Bacteria	2|Bacteria	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane	kdpA	GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0030312,GO:0030955,GO:0031420,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043167,GO:0043169,GO:0043492,GO:0044464,GO:0046872,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132	3.6.3.12	ko:K01546	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	iSB619.SA_RS00490	KdpA
SHD1_k127_905450_0	861299.J421_1938	2.597e-121	408.0	COG0642@1|root,COG2205@2|Bacteria,1ZUG2@142182|Gemmatimonadetes	861299.J421_1938|-	T	Domain of unknown function (DUF4118)	-	-	2.7.13.3	ko:K07646	ko02020,map02020	M00454	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	-
SHD1_k127_905450_2	861299.J421_1888	2.294e-14	73.0	COG0745@1|root,COG0745@2|Bacteria,1ZUUR@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Transcriptional regulatory protein, C terminal	-	-	-	ko:K07667	ko02020,ko02024,map02020,map02024	M00454	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
SHD1_k127_905722_10	861299.J421_0118	4.845e-27	128.0	COG3325@1|root,COG3325@2|Bacteria	2|Bacteria	G	chitin binding	-	-	3.2.1.14	ko:K01183	ko00520,ko01100,map00520,map01100	-	R01206,R02334	RC00467	ko00000,ko00001,ko01000	-	GH18	-	Calx-beta,Glyco_hydro_18,PA14,PKD,fn3
SHD1_k127_905722_19	379066.GAU_2926	1.671e-08	68.0	29X7J@1|root,30IWT@2|Bacteria,1ZV69@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_905722_17	452637.Oter_2379	4.585e-13	79.0	COG2834@1|root,COG2834@2|Bacteria,46YSI@74201|Verrucomicrobia,3K9A7@414999|Opitutae	414999|Opitutae	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_905722_15	690850.Desaf_0357	2.437e-18	90.0	COG2155@1|root,COG2155@2|Bacteria,1N77I@1224|Proteobacteria	1224|Proteobacteria	S	Domain of unknown function (DUF378)	-	-	-	ko:K09779	-	-	-	-	ko00000	-	-	-	DUF378
SHD1_k127_905722_8	452637.Oter_1107	2.23e-50	191.0	COG0789@1|root,COG5012@1|root,COG0789@2|Bacteria,COG5012@2|Bacteria,46V45@74201|Verrucomicrobia	74201|Verrucomicrobia	K	helix_turn_helix, mercury resistance	-	-	-	ko:K22491	-	-	-	-	ko00000,ko03000	-	-	-	B12-binding,B12-binding_2,MerR_1
SHD1_k127_905722_4	1382359.JIAL01000001_gene2460	9.889e-152	496.0	COG1680@1|root,COG1680@2|Bacteria,3Y3DY@57723|Acidobacteria,2JHVC@204432|Acidobacteriia	204432|Acidobacteriia	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
SHD1_k127_905722_12	1185876.BN8_05257	1.439e-22	109.0	COG5183@1|root,COG5183@2|Bacteria,4NR0S@976|Bacteroidetes,47YIT@768503|Cytophagia	976|Bacteroidetes	A	PRC-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	PRC
SHD1_k127_905722_18	1027292.HMPREF9372_1903	9.199e-12	76.0	COG3861@1|root,COG3861@2|Bacteria,1V24Q@1239|Firmicutes,4HHDZ@91061|Bacilli,26EWF@186818|Planococcaceae	91061|Bacilli	S	Domain of unknown function (DUF2382)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2382,YflT
SHD1_k127_905722_13	910964.GEAM_1463	1.675e-21	109.0	2CCY9@1|root,32W6X@2|Bacteria,1N3DH@1224|Proteobacteria,1SBBY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_905722_3	204669.Acid345_3211	1.455e-168	552.0	COG1228@1|root,COG1228@2|Bacteria,3Y32S@57723|Acidobacteria,2JIA1@204432|Acidobacteriia	2|Bacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
SHD1_k127_905722_9	1382359.JIAL01000001_gene1442	1.411e-28	119.0	COG2261@1|root,COG2261@2|Bacteria	2|Bacteria	S	Transglycosylase associated protein	MA20_01300	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
SHD1_k127_905722_7	861299.J421_1482	1.382e-60	221.0	2C80W@1|root,330EI@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_905722_5	861299.J421_1481	3.905e-126	412.0	COG1994@1|root,COG1994@2|Bacteria	2|Bacteria	S	metallopeptidase activity	spoIVFB	-	-	ko:K06402	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M50
SHD1_k127_905722_2	861299.J421_4156	1.976e-185	586.0	COG1459@1|root,COG1459@2|Bacteria,1ZT63@142182|Gemmatimonadetes	142182|Gemmatimonadetes	U	Type II secretion system (T2SS), protein F	-	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
SHD1_k127_905722_1	861299.J421_4157	5.644e-194	613.0	COG2805@1|root,COG2805@2|Bacteria,1ZSQE@142182|Gemmatimonadetes	142182|Gemmatimonadetes	NU	Type II/IV secretion system protein	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
SHD1_k127_905722_0	379066.GAU_2570	1.867e-289	900.0	COG2804@1|root,COG2804@2|Bacteria,1ZSSN@142182|Gemmatimonadetes	142182|Gemmatimonadetes	NU	Type II secretion system (T2SS), protein E, N-terminal domain	-	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
SHD1_k127_905722_16	861299.J421_4159	5.742e-14	81.0	COG1555@1|root,COG1555@2|Bacteria,1ZV96@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	Helix-hairpin-helix motif	-	-	-	ko:K02237	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	HHH_3
SHD1_k127_905722_6	1410619.SRDD_27080	1.565e-82	287.0	COG1234@1|root,COG1234@2|Bacteria,1R64Z@1224|Proteobacteria,1S1KW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	COG1234 Metal-dependent hydrolases of the beta-lactamase superfamily III	-	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
SHD1_k127_905722_11	1379698.RBG1_1C00001G0436	8.364e-23	101.0	COG2234@1|root,COG2234@2|Bacteria,2NP7A@2323|unclassified Bacteria	2|Bacteria	S	Peptidase M28	ywaD	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
SHD1_k127_90943_11	861299.J421_2776	7.754e-36	138.0	COG0089@1|root,COG0089@2|Bacteria,1ZTWN@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome	rplW	-	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
SHD1_k127_90943_0	1379270.AUXF01000004_gene3030	2.345e-148	473.0	COG0090@1|root,COG0090@2|Bacteria,1ZSUP@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	-	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
SHD1_k127_90943_8	861299.J421_2778	5.329e-41	154.0	COG0185@1|root,COG0185@2|Bacteria,1ZU04@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rpsS	-	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
SHD1_k127_90943_7	861299.J421_2779	1.885e-44	164.0	COG0091@1|root,COG0091@2|Bacteria,1ZTVF@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rplV	-	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
SHD1_k127_90943_1	379066.GAU_0879	1.031e-109	364.0	COG0092@1|root,COG0092@2|Bacteria,1ZTFT@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	-	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
SHD1_k127_90943_3	1379270.AUXF01000004_gene3026	1.118e-69	239.0	COG0197@1|root,COG0197@2|Bacteria,1ZTKB@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs	rplP	-	-	ko:K02878	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
SHD1_k127_90943_13	1121926.AXWO01000002_gene1556	1.069e-06	53.0	COG0255@1|root,COG0255@2|Bacteria,2IQ6V@201174|Actinobacteria,4EYWT@85014|Glycomycetales	201174|Actinobacteria	J	Ribosomal L29 protein	rpmC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008150,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
SHD1_k127_90943_10	861299.J421_2783	2.735e-38	145.0	COG0186@1|root,COG0186@2|Bacteria,1ZU1B@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rpsQ	-	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
SHD1_k127_90943_4	379066.GAU_0883	1.933e-66	227.0	COG0093@1|root,COG0093@2|Bacteria,1ZTPT@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rplN	-	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
SHD1_k127_90943_6	861299.J421_2785	2.745e-45	168.0	COG0198@1|root,COG0198@2|Bacteria,1ZTRE@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit	rplX	-	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,ribosomal_L24
SHD1_k127_90943_2	861299.J421_2786	2.346e-94	314.0	COG0094@1|root,COG0094@2|Bacteria,1ZSTZ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rplE	-	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
SHD1_k127_90943_12	1379698.RBG1_1C00001G1583	5.782e-24	101.0	COG0199@1|root,COG0199@2|Bacteria,2NPW7@2323|unclassified Bacteria	2|Bacteria	J	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site	rpsN	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
SHD1_k127_90943_9	682795.AciX8_0587	1.043e-40	154.0	COG0096@1|root,COG0096@2|Bacteria,3Y4IE@57723|Acidobacteria,2JJ74@204432|Acidobacteriia	204432|Acidobacteriia	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rpsH	-	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
SHD1_k127_90943_5	861299.J421_2789	2.735e-57	203.0	COG0097@1|root,COG0097@2|Bacteria,1ZTJ8@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rplF	-	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
SHD1_k127_909490_2	861299.J421_4468	5.151e-61	215.0	COG0537@1|root,COG0537@2|Bacteria,1ZTMB@142182|Gemmatimonadetes	142182|Gemmatimonadetes	FG	HIT domain	-	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
SHD1_k127_909490_0	1379270.AUXF01000001_gene2535	0.0	1114.0	COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,1ZT89@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Transketolase, pyrimidine binding domain	-	-	1.2.4.4	ko:K11381	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,Transket_pyr,Transketolase_C
SHD1_k127_909490_1	861299.J421_4478	8.517e-254	793.0	COG1574@1|root,COG1574@2|Bacteria,1ZU9S@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
SHD1_k127_909490_4	1379270.AUXF01000001_gene2507	5.588e-27	113.0	2FCBU@1|root,344FF@2|Bacteria,1ZU39@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_909490_3	861299.J421_4480	1.006e-42	159.0	COG1403@1|root,COG1403@2|Bacteria,1ZV49@142182|Gemmatimonadetes	142182|Gemmatimonadetes	V	HNH nucleases	-	-	-	-	-	-	-	-	-	-	-	-	HNH_5
SHD1_k127_909656_2	485918.Cpin_2598	1.295e-43	168.0	COG1416@1|root,COG1416@2|Bacteria,4NH85@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_909656_1	861299.J421_1806	3.364e-65	235.0	COG3258@1|root,COG3258@2|Bacteria,1ZUR6@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	1.8.2.2	ko:K19713	-	-	-	-	ko00000,ko01000	-	-	-	-
SHD1_k127_909656_0	1382359.JIAL01000001_gene2689	2.707e-261	823.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,3Y3NT@57723|Acidobacteria,2JIBK@204432|Acidobacteriia	204432|Acidobacteriia	EU	Dipeptidyl peptidase IV (DPP IV) N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	DPPIV_N,PD40,Peptidase_S9
SHD1_k127_909656_3	1122182.KB903835_gene4692	0.0001963	51.0	COG3170@1|root,COG3170@2|Bacteria,2GVM2@201174|Actinobacteria,4DFSI@85008|Micromonosporales	201174|Actinobacteria	NU	Tfp pilus assembly protein FimV	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
SHD1_k127_913478_0	861299.J421_2694	1.513e-270	842.0	COG0433@1|root,COG0433@2|Bacteria,1ZURZ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	COG0433 Predicted ATPase	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	-
SHD1_k127_913478_3	861299.J421_2695	9.682e-28	126.0	2FF43@1|root,34729@2|Bacteria,1ZTX6@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_913478_1	861299.J421_2696	8.005e-151	486.0	COG0420@1|root,COG0420@2|Bacteria,1ZSPE@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	Calcineurin-like phosphoesterase superfamily domain	-	-	-	ko:K03547	-	-	-	-	ko00000,ko03400	-	-	-	Metallophos
SHD1_k127_913478_2	861299.J421_2697	7.3e-101	336.0	COG0419@1|root,COG0419@2|Bacteria,1ZTD9@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	AAA domain	-	-	-	ko:K03546	-	-	-	-	ko00000,ko03400	-	-	-	SMC_N
SHD1_k127_923275_3	861299.J421_3363	2.366e-101	339.0	COG0133@1|root,COG0133@2|Bacteria,1ZSUM@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
SHD1_k127_923275_6	861299.J421_3364	7.027e-50	186.0	COG0135@1|root,COG0135@2|Bacteria,1ZTRT@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	N-(5'phosphoribosyl)anthranilate (PRA) isomerase	-	-	5.3.1.24	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03509	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	PRAI
SHD1_k127_923275_5	861299.J421_3365	1.879e-65	233.0	COG0134@1|root,COG0134@2|Bacteria,1ZTMA@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Indole-3-glycerol phosphate synthase	-	-	4.1.1.48	ko:K01609	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508	RC00944	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS
SHD1_k127_923275_4	861299.J421_3366	1.09e-95	324.0	COG1974@1|root,COG1974@2|Bacteria,1ZSSM@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	-	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
SHD1_k127_923275_1	861299.J421_3367	3.673e-115	381.0	COG0547@1|root,COG0547@2|Bacteria,1ZTDS@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	-	2.4.2.18	ko:K00766	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R01073	RC00440	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
SHD1_k127_923275_0	1379270.AUXF01000006_gene162	2.425e-167	537.0	COG3605@1|root,COG3605@2|Bacteria,1ZT8P@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2
SHD1_k127_923275_2	861299.J421_3369	4.219e-102	338.0	COG0101@1|root,COG0101@2|Bacteria,1ZSRZ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	-	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
SHD1_k127_923275_7	768670.Calni_1031	1.471e-15	84.0	COG0176@1|root,COG0176@2|Bacteria,2GF1X@200930|Deferribacteres	200930|Deferribacteres	H	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
SHD1_k127_930135_2	1379270.AUXF01000005_gene678	9.784e-82	278.0	COG0457@1|root,COG0457@2|Bacteria,1ZTK5@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_2
SHD1_k127_930135_1	861299.J421_3065	7.458e-99	333.0	2DUTE@1|root,33S5W@2|Bacteria,1ZSMI@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_930135_0	1379270.AUXF01000002_gene1574	1.124e-170	555.0	COG1080@1|root,COG1080@2|Bacteria,1ZT3W@142182|Gemmatimonadetes	2|Bacteria	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	-	-	2.7.1.202,2.7.3.9	ko:K02768,ko:K08483,ko:K11183,ko:K11189	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273	R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1,8.A.7	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C,PTS-HPr,PTS_EIIA_1
SHD1_k127_938073_1	861299.J421_0626	8.483e-82	280.0	COG2819@1|root,COG2819@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on ester bonds	-	-	-	ko:K07017	-	-	-	-	ko00000	-	-	-	Esterase
SHD1_k127_938073_4	266117.Rxyl_3191	1.146e-38	149.0	COG1917@1|root,COG1917@2|Bacteria,2I5JH@201174|Actinobacteria,4CTYM@84995|Rubrobacteria	84995|Rubrobacteria	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
SHD1_k127_938073_6	768706.Desor_3591	3.465e-22	104.0	COG2318@1|root,COG2318@2|Bacteria,1V51W@1239|Firmicutes	1239|Firmicutes	S	DinB family	dinB	-	-	-	-	-	-	-	-	-	-	-	DinB
SHD1_k127_938073_0	861299.J421_1348	1.175e-157	509.0	COG1073@1|root,COG1073@2|Bacteria,1ZU9Q@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
SHD1_k127_938073_2	861299.J421_1638	2.628e-67	237.0	COG1247@1|root,COG1247@2|Bacteria	2|Bacteria	M	phosphinothricin N-acetyltransferase activity	pat	-	2.3.1.183	ko:K03823	ko00440,ko01130,map00440,map01130	-	R08871,R08938	RC00004,RC00064	ko00000,ko00001,ko01000	-	-	-	Acetyltransf_4
SHD1_k127_938073_5	1120950.KB892762_gene5508	1.2e-32	130.0	COG4274@1|root,COG4274@2|Bacteria,2HWQ8@201174|Actinobacteria,4DW30@85009|Propionibacteriales	201174|Actinobacteria	S	GYD domain	-	-	-	-	-	-	-	-	-	-	-	-	GYD
SHD1_k127_938073_3	1267533.KB906738_gene2275	1.418e-51	185.0	COG0251@1|root,COG0251@2|Bacteria	2|Bacteria	J	oxidation-reduction process	-	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
SHD1_k127_941339_0	1382356.JQMP01000003_gene2067	1.307e-193	622.0	COG4986@1|root,COG4986@2|Bacteria,2G5UN@200795|Chloroflexi	200795|Chloroflexi	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
SHD1_k127_941339_1	261292.Nit79A3_0448	4.487e-20	103.0	COG1652@1|root,COG1652@2|Bacteria,1MUBV@1224|Proteobacteria,2VIZJ@28216|Betaproteobacteria,3722Y@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Lysin motif	-	-	-	-	-	-	-	-	-	-	-	-	LysM
SHD1_k127_942638_6	204669.Acid345_0436	3.095e-65	227.0	COG3794@1|root,COG3794@2|Bacteria,3Y4C0@57723|Acidobacteria,2JJME@204432|Acidobacteriia	204432|Acidobacteriia	C	Polysaccharide lyase family 4, domain II	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
SHD1_k127_942638_3	204669.Acid345_0437	4.481e-86	293.0	COG1622@1|root,COG1622@2|Bacteria,3Y4UA@57723|Acidobacteria,2JJKD@204432|Acidobacteriia	204432|Acidobacteriia	C	PFAM cytochrome c oxidase subunit II	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2
SHD1_k127_942638_0	204669.Acid345_0438	3.78e-277	863.0	COG0843@1|root,COG0843@2|Bacteria,3Y2NS@57723|Acidobacteria,2JHVG@204432|Acidobacteriia	204432|Acidobacteriia	C	Belongs to the heme-copper respiratory oxidase family	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
SHD1_k127_942638_8	234267.Acid_5591	6.609e-31	141.0	COG1845@1|root,COG1845@2|Bacteria,3Y2KJ@57723|Acidobacteria	57723|Acidobacteria	C	PFAM cytochrome c oxidase, subunit III	-	-	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
SHD1_k127_942638_5	204669.Acid345_0440	3.006e-65	230.0	COG1845@1|root,COG1845@2|Bacteria,3Y5GJ@57723|Acidobacteria,2JK2M@204432|Acidobacteriia	204432|Acidobacteriia	C	Cytochrome c oxidase subunit III	-	-	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
SHD1_k127_942638_2	379066.GAU_2880	2.583e-91	323.0	COG5002@1|root,COG5002@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
SHD1_k127_942638_4	1123311.KB904462_gene1114	3.504e-67	237.0	COG0745@1|root,COG0745@2|Bacteria,1TS81@1239|Firmicutes,4HEGD@91061|Bacilli	91061|Bacilli	T	Transcriptional regulator	mprA1	-	-	ko:K07669	ko02020,map02020	M00460	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
SHD1_k127_942638_7	861299.J421_1214	1.032e-35	145.0	COG1595@1|root,COG1595@2|Bacteria,1ZV5F@142182|Gemmatimonadetes	2|Bacteria	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	PD40,PQQ_2,Sigma70_r2,Sigma70_r4_2,WD40
SHD1_k127_942638_1	861299.J421_2181	7.942e-96	344.0	COG4995@1|root,COG4995@2|Bacteria,1ZUKA@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT
SHD1_k127_947745_1	946077.W5A_01685	1.163e-32	127.0	COG0396@1|root,COG0396@2|Bacteria,4NEMY@976|Bacteroidetes,1HWTU@117743|Flavobacteriia	976|Bacteroidetes	O	Part of SUF system involved in inserting iron-sulfur clusters into proteins	sufC	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
SHD1_k127_947745_0	861299.J421_2088	6.328e-131	437.0	COG0719@1|root,COG0719@2|Bacteria,1ZSTG@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	Uncharacterized protein family (UPF0051)	-	-	-	ko:K09015	-	-	-	-	ko00000	-	-	-	UPF0051
SHD1_k127_947745_2	1449044.JMLE01000024_gene290	0.0008535	47.0	COG1716@1|root,COG1716@2|Bacteria	2|Bacteria	T	histone H2A K63-linked ubiquitination	-	-	-	-	-	-	-	-	-	-	-	-	FHA,HTH_8,Yop-YscD_cpl
SHD1_k127_956356_0	379066.GAU_0649	2.755e-182	581.0	COG2204@1|root,COG2204@2|Bacteria,1ZSW0@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	Sigma-54 interaction domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
SHD1_k127_956356_1	379066.GAU_0652	4.622e-58	208.0	COG5000@1|root,COG5000@2|Bacteria,1ZTBX@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
SHD1_k127_960395_4	861299.J421_2626	1.184e-43	161.0	COG1051@1|root,COG1051@2|Bacteria,1ZTP5@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
SHD1_k127_960395_3	1379270.AUXF01000004_gene3175	3.421e-54	203.0	COG2207@1|root,COG2207@2|Bacteria,1ZUCN@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
SHD1_k127_960395_0	861299.J421_2627	3.26e-271	845.0	COG0056@1|root,COG0056@2|Bacteria,1ZSNY@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
SHD1_k127_960395_2	861299.J421_2628	6.343e-116	379.0	COG0224@1|root,COG0224@2|Bacteria,1ZSZR@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	-	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
SHD1_k127_960395_1	379066.GAU_0716	7.819e-246	766.0	COG0055@1|root,COG0055@2|Bacteria,1ZSNP@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
SHD1_k127_960395_6	379066.GAU_0717	6.993e-29	118.0	COG0355@1|root,COG0355@2|Bacteria,1ZU1K@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	-	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE_N
SHD1_k127_960395_5	1379270.AUXF01000004_gene3162	3.532e-34	142.0	2FAWT@1|root,3433T@2|Bacteria,1ZTS1@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_963992_4	861299.J421_2500	4.458e-28	116.0	COG0642@1|root,COG0642@2|Bacteria,1ZTZE@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
SHD1_k127_963992_0	861299.J421_3034	1.311e-249	788.0	COG0465@1|root,COG0465@2|Bacteria,1ZSRI@142182|Gemmatimonadetes	2|Bacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009056,GO:0009057,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0030163,GO:0042623,GO:0042802,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
SHD1_k127_963992_3	1121957.ATVL01000010_gene392	5.467e-106	359.0	COG0501@1|root,COG0501@2|Bacteria,4NESF@976|Bacteroidetes,47KTS@768503|Cytophagia	976|Bacteroidetes	O	Zn-dependent protease with chaperone function	-	-	3.4.24.84	ko:K03799,ko:K06013	ko00900,ko01130,map00900,map01130	M00743	R09845	RC00141	ko00000,ko00001,ko00002,ko01000,ko01002,ko04147	-	-	-	Peptidase_M48,Peptidase_M48_N
SHD1_k127_963992_1	861299.J421_2513	9.274e-226	705.0	COG4867@1|root,COG4867@2|Bacteria,1ZT0B@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA_2
SHD1_k127_963992_2	861299.J421_2514	8.628e-114	381.0	COG0477@1|root,COG2814@2|Bacteria,1ZSUR@142182|Gemmatimonadetes	142182|Gemmatimonadetes	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
SHD1_k127_965432_1	861299.J421_3362	3.772e-94	316.0	COG0159@1|root,COG0159@2|Bacteria,1ZSYU@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
SHD1_k127_965432_0	1379270.AUXF01000006_gene169	1.081e-146	479.0	COG2206@1|root,COG2206@2|Bacteria,1ZUTT@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	-	-	-	-	-	-	-	-	-	HD
SHD1_k127_965432_2	1379270.AUXF01000006_gene168	2.466e-11	66.0	COG1413@1|root,COG1413@2|Bacteria,1ZUI4@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	HEAT repeats	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
SHD1_k127_968044_2	1380394.JADL01000009_gene3303	1.136e-79	269.0	COG0745@1|root,COG0745@2|Bacteria,1MX29@1224|Proteobacteria,2TV8G@28211|Alphaproteobacteria,2JPZF@204441|Rhodospirillales	204441|Rhodospirillales	KT	RESPONSE REGULATOR receiver	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_968044_0	264198.Reut_A3203	2.299e-91	304.0	COG3391@1|root,COG3391@2|Bacteria,1N25Z@1224|Proteobacteria,2VMGE@28216|Betaproteobacteria,1K4GK@119060|Burkholderiaceae	28216|Betaproteobacteria	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
SHD1_k127_968044_1	379066.GAU_0047	3.193e-89	300.0	COG2755@1|root,COG2755@2|Bacteria,1ZUS0@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	GDSL-like Lipase/Acylhydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
SHD1_k127_968044_3	251221.35210998	3.108e-26	118.0	COG0842@1|root,COG0842@2|Bacteria	2|Bacteria	V	Transport permease protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_971085_5	861299.J421_2939	2.396e-56	208.0	COG0125@1|root,COG0125@2|Bacteria,1ZTPV@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
SHD1_k127_971085_7	1379270.AUXF01000005_gene498	5.666e-37	149.0	COG3679@1|root,COG3679@2|Bacteria,1ZTRW@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Control of competence regulator ComK, YlbF/YmcA	-	-	-	-	-	-	-	-	-	-	-	-	Com_YlbF
SHD1_k127_971085_3	861299.J421_2937	2.438e-96	323.0	COG2890@1|root,COG2890@2|Bacteria,1ZTQX@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Methyltransferase small domain	-	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS
SHD1_k127_971085_2	379066.GAU_1184	3.645e-150	484.0	COG0216@1|root,COG0216@2|Bacteria,1ZSNT@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
SHD1_k127_971085_9	269799.Gmet_0377	1.887e-25	108.0	COG0254@1|root,COG0254@2|Bacteria,1PT0H@1224|Proteobacteria,42V2Z@68525|delta/epsilon subdivisions,2WRGA@28221|Deltaproteobacteria,43VM9@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Binds the 23S rRNA	rpmE	-	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
SHD1_k127_971085_1	1298858.AUEL01000019_gene3128	2.205e-239	756.0	COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2TS2Q@28211|Alphaproteobacteria,43H8P@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	Pyrrolo-quinoline quinone	-	-	1.1.2.8	ko:K00114	ko00010,ko00625,ko01100,ko01110,ko01120,ko01130,map00010,map00625,map01100,map01110,map01120,map01130	-	R05062,R05198,R05285	RC00087,RC00088,RC01039	ko00000,ko00001,ko01000	-	-	-	PQQ,PQQ_2
SHD1_k127_971085_8	1121943.KB900010_gene2734	3.421e-30	139.0	COG2010@1|root,COG2010@2|Bacteria,1RHET@1224|Proteobacteria	1224|Proteobacteria	C	cytochrome c	-	-	-	ko:K00406	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	Cytochrome_CBB3
SHD1_k127_971085_4	1121943.KB900010_gene2733	1.278e-85	301.0	COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,1MWHZ@1224|Proteobacteria,1S5PJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	PFAM Cytochrome C oxidase subunit II	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,Cytochrom_C
SHD1_k127_971085_0	861299.J421_0300	3.14e-268	845.0	COG0843@1|root,COG0843@2|Bacteria,1ZSMG@142182|Gemmatimonadetes	2|Bacteria	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	-	-	1.9.3.1	ko:K02274,ko:K15408	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1,COX3
SHD1_k127_971085_6	861299.J421_0300	5.728e-52	192.0	COG0843@1|root,COG0843@2|Bacteria,1ZSMG@142182|Gemmatimonadetes	2|Bacteria	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	-	-	1.9.3.1	ko:K02274,ko:K15408	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1,COX3
SHD1_k127_971085_10	861299.J421_0301	1.575e-12	76.0	2E5I0@1|root,3309C@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_981922_3	1379270.AUXF01000003_gene3738	4.623e-57	211.0	COG3127@1|root,COG3127@2|Bacteria,1ZT3A@142182|Gemmatimonadetes	142182|Gemmatimonadetes	Q	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
SHD1_k127_981922_1	518766.Rmar_0541	2.45e-82	280.0	COG4181@1|root,COG4181@2|Bacteria,4NEVZ@976|Bacteroidetes,1FJY7@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	Q	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SHD1_k127_981922_2	1185876.BN8_05035	5.752e-65	234.0	COG2755@1|root,COG2755@2|Bacteria,4NE58@976|Bacteroidetes,47P77@768503|Cytophagia	976|Bacteroidetes	E	GDSL-like Lipase/Acylhydrolase family	tesA	-	3.1.1.5	ko:K10804	ko01040,map01040	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	-	Lipase_GDSL_2
SHD1_k127_981922_0	861299.J421_3685	5.556e-96	317.0	COG0231@1|root,COG0231@2|Bacteria,1ZT2N@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	efp	-	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
SHD1_k127_983487_0	861299.J421_3547	1.515e-238	767.0	COG1452@1|root,COG1452@2|Bacteria,1ZT14@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_990548_2	379066.GAU_0710	6.898e-65	233.0	COG0568@1|root,COG0568@2|Bacteria,1ZTCX@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
SHD1_k127_990548_0	379066.GAU_1367	4.338e-269	852.0	COG0460@1|root,COG0527@1|root,COG0460@2|Bacteria,COG0527@2|Bacteria,1ZSSS@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	ACT domain	-	-	1.1.1.3,2.7.2.4	ko:K12524	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00017,M00018,M00526,M00527	R00480,R01773,R01775	RC00002,RC00043,RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT_7,Homoserine_dh,NAD_binding_3
SHD1_k127_990548_1	251221.35214401	1.523e-148	478.0	COG1902@1|root,COG1902@2|Bacteria,1G2EB@1117|Cyanobacteria	1117|Cyanobacteria	C	PFAM NADH flavin oxidoreductase NADH oxidase	-	-	1.3.1.34	ko:K00219	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_FMN
SHD1_k127_990548_4	292564.Cyagr_2033	1.559e-31	131.0	COG0454@1|root,COG0454@2|Bacteria	2|Bacteria	K	-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
SHD1_k127_990548_3	1280390.CBQR020000098_gene2203	3.652e-45	173.0	COG2318@1|root,COG2318@2|Bacteria,1V6MV@1239|Firmicutes,4HH68@91061|Bacilli,26YC6@186822|Paenibacillaceae	91061|Bacilli	S	Squalene--hopene cyclase	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
SHD1_k127_990548_5	1379270.AUXF01000001_gene2556	2.447e-23	106.0	COG0515@1|root,COG0515@2|Bacteria	1379270.AUXF01000001_gene2556|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD1_k127_993174_6	861299.J421_2933	1.32e-26	112.0	COG0146@1|root,COG0146@2|Bacteria,1ZTH4@142182|Gemmatimonadetes	142182|Gemmatimonadetes	EQ	Hydantoinase B/oxoprolinase	-	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
SHD1_k127_993174_0	861299.J421_2932	1.08e-205	662.0	COG0145@1|root,COG0145@2|Bacteria,1ZT73@142182|Gemmatimonadetes	142182|Gemmatimonadetes	EQ	Hydantoinase/oxoprolinase N-terminal region	-	-	3.5.2.14	ko:K01473	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A
SHD1_k127_993174_4	404380.Gbem_1001	4.864e-68	251.0	COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,42MPS@68525|delta/epsilon subdivisions,2WIUD@28221|Deltaproteobacteria,43TVN@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Transfers the fatty acyl group on membrane lipoproteins	lnt	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
SHD1_k127_993174_1	379066.GAU_1177	2.272e-137	452.0	COG0673@1|root,COG0673@2|Bacteria,1ZSV9@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Homoserine dehydrogenase, NAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
SHD1_k127_993174_3	861299.J421_2928	2.35e-116	395.0	COG2385@1|root,COG2385@2|Bacteria,1ZT25@142182|Gemmatimonadetes	142182|Gemmatimonadetes	D	Stage II sporulation protein	-	-	-	ko:K06381	-	-	-	-	ko00000	-	-	-	SpoIID
SHD1_k127_993174_2	379066.GAU_1175	9.224e-132	437.0	COG0001@1|root,COG0001@2|Bacteria,1ZSYC@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Aminotransferase class-III	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
## 3137 queries scanned
## Total time (seconds): 112.45552802085876
## Rate: 27.90 q/s