## Mon Nov 11 23:41:37 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/4635/S/SHD2_bin.18.fa -m mmseqs --itype genome -o SHD2_bin.18 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/bins_4635/SHD2_bin.18 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
SHD2_k127_1073394_5	1449049.JONW01000005_gene1369	2.719e-42	159.0	COG1028@1|root,COG1028@2|Bacteria,1RF8S@1224|Proteobacteria,2TWEU@28211|Alphaproteobacteria,2KI9R@204458|Caulobacterales	204458|Caulobacterales	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
SHD2_k127_1073394_7	1134912.AJTV01000002_gene1748	6.371e-34	140.0	2AC8B@1|root,311T0@2|Bacteria,1NK0P@1224|Proteobacteria,2VD5M@28211|Alphaproteobacteria,3713U@31993|Methylocystaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_1073394_0	172088.AUGA01000007_gene8331	6.941e-202	637.0	COG0112@1|root,COG0112@2|Bacteria,1R3T8@1224|Proteobacteria,2U2N3@28211|Alphaproteobacteria,3JT5C@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	-	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
SHD2_k127_1073394_12	323097.Nham_2319	1.621e-09	64.0	2C7HC@1|root,2ZEX5@2|Bacteria,1N7NS@1224|Proteobacteria,2UGBA@28211|Alphaproteobacteria,3K173@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_1073394_2	107636.JQNK01000009_gene2634	1.29e-85	295.0	COG0484@1|root,COG0484@2|Bacteria,1MUZ4@1224|Proteobacteria,2TR01@28211|Alphaproteobacteria,36XSC@31993|Methylocystaceae	28211|Alphaproteobacteria	O	DnaJ C terminal domain	dnaJ2	-	-	-	-	-	-	-	-	-	-	-	DnaJ,DnaJ_C
SHD2_k127_1073394_8	204669.Acid345_3563	3.319e-33	132.0	COG1695@1|root,COG1695@2|Bacteria	2|Bacteria	K	negative regulation of transcription, DNA-templated	-	-	-	ko:K10947	-	-	-	-	ko00000,ko03000	-	-	-	PadR
SHD2_k127_1073394_11	204669.Acid345_3564	2.265e-13	78.0	COG4709@1|root,COG4709@2|Bacteria	2|Bacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	Sensor
SHD2_k127_1073394_13	93220.LV28_15125	4.164e-09	65.0	COG0790@1|root,COG0790@2|Bacteria,1MWPA@1224|Proteobacteria,2VR5X@28216|Betaproteobacteria,1K1U7@119060|Burkholderiaceae	28216|Betaproteobacteria	S	PFAM Sel1 domain protein repeat-containing protein	-	-	-	ko:K07126	-	-	-	-	ko00000	-	-	-	Sel1
SHD2_k127_1073394_3	1238182.C882_1344	2.803e-85	292.0	COG0053@1|root,COG0053@2|Bacteria,1MUDS@1224|Proteobacteria,2TT78@28211|Alphaproteobacteria,2JPSR@204441|Rhodospirillales	204441|Rhodospirillales	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	-	ko:K13283	-	-	-	-	ko00000,ko02000	2.A.4.7.1	-	-	Cation_efflux,ZT_dimer
SHD2_k127_1073394_1	1040989.AWZU01000024_gene6462	1.906e-98	324.0	COG1028@1|root,COG1028@2|Bacteria,1MVT2@1224|Proteobacteria,2TQKU@28211|Alphaproteobacteria,3JS01@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	fixR	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
SHD2_k127_1073394_10	1333998.M2A_2633	7.464e-19	85.0	COG1028@1|root,COG1028@2|Bacteria,1MVT2@1224|Proteobacteria,2TQKU@28211|Alphaproteobacteria,4BR8X@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	fixR	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
SHD2_k127_1073394_4	314285.KT71_02627	5.716e-52	205.0	COG5616@1|root,COG5616@2|Bacteria,1NSKC@1224|Proteobacteria,1S0KQ@1236|Gammaproteobacteria,1J82F@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	cAMP biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_1073394_9	876269.ARWA01000001_gene1947	1.093e-31	128.0	COG2149@1|root,COG2149@2|Bacteria,1N7T3@1224|Proteobacteria,2UG6T@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Domain of unknown function (DUF202)	-	-	-	ko:K00389	-	-	-	-	ko00000	-	-	-	DUF202
SHD2_k127_1073394_6	1248916.ANFY01000003_gene860	4.593e-36	141.0	28KEA@1|root,2ZA0J@2|Bacteria,1R5TS@1224|Proteobacteria,2U48U@28211|Alphaproteobacteria,2K5IU@204457|Sphingomonadales	204457|Sphingomonadales	H	Sulfotransferase domain	-	-	2.8.2.1	ko:K01014	ko05204,map05204	-	R01242	RC00007,RC00128	ko00000,ko00001,ko01000	-	-	-	Sulfotransfer_1
SHD2_k127_1105845_3	1206730.BAGA01000070_gene1558	3.133e-63	219.0	COG2030@1|root,COG2030@2|Bacteria,2IK9K@201174|Actinobacteria,4G0UU@85025|Nocardiaceae	201174|Actinobacteria	I	MaoC like domain	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
SHD2_k127_1105845_2	1112216.JH594425_gene234	9.068e-82	283.0	COG2301@1|root,COG2301@2|Bacteria,1MW0A@1224|Proteobacteria,2TTC0@28211|Alphaproteobacteria,2K2E1@204457|Sphingomonadales	204457|Sphingomonadales	G	Belongs to the HpcH HpaI aldolase family	-	-	4.1.3.34	ko:K01644	ko02020,map02020	-	R00362	RC00067,RC01118	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
SHD2_k127_1105845_0	861299.J421_0972	1.039e-240	760.0	COG1297@1|root,COG1297@2|Bacteria	2|Bacteria	S	iron-nicotianamine transmembrane transporter activity	oliA	GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0008150,GO:0016020,GO:0022857,GO:0051179,GO:0051234,GO:0055085	-	-	-	-	-	-	-	-	-	-	OPT
SHD2_k127_1105845_1	1333998.M2A_2538	9.688e-93	317.0	COG1462@1|root,COG1462@2|Bacteria,1QK8Y@1224|Proteobacteria,2TTVW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Curli production assembly/transport component CsgG	-	-	-	ko:K06214,ko:K13586	ko04112,map04112	-	-	-	ko00000,ko00001,ko02044	-	-	-	CsgG
SHD2_k127_1105845_4	588932.JHOF01000008_gene579	2.657e-06	52.0	2EEE4@1|root,33885@2|Bacteria,1NFNU@1224|Proteobacteria,2UJ5V@28211|Alphaproteobacteria,2KHC9@204458|Caulobacterales	204458|Caulobacterales	-	-	-	-	-	ko:K13585	ko04112,map04112	-	-	-	ko00000,ko00001	-	-	-	-
SHD2_k127_1131556_124	292415.Tbd_1902	4.866e-12	66.0	COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,2VHN4@28216|Betaproteobacteria,1KSXK@119069|Hydrogenophilales	119069|Hydrogenophilales	J	DALR_2	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e
SHD2_k127_1131556_6	1282876.BAOK01000001_gene2469	7.545e-249	777.0	COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,2TSK4@28211|Alphaproteobacteria,4BPHW@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Belongs to the alpha-IPM synthase homocitrate synthase family	MA20_26350	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
SHD2_k127_1131556_75	316274.Haur_1661	5.588e-70	247.0	COG2962@1|root,COG2962@2|Bacteria,2G6C2@200795|Chloroflexi,375DH@32061|Chloroflexia	32061|Chloroflexia	S	TIGRFAM RarD protein, DMT superfamily transporter	-	-	-	ko:K05786	-	-	-	-	ko00000,ko02000	2.A.7.7	-	-	EamA
SHD2_k127_1131556_97	530564.Psta_0407	1.071e-44	169.0	COG1611@1|root,COG1611@2|Bacteria,2IZK9@203682|Planctomycetes	203682|Planctomycetes	S	Belongs to the LOG family	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
SHD2_k127_1131556_10	402881.Plav_1113	3.674e-227	721.0	COG5265@1|root,COG5265@2|Bacteria,1NSKS@1224|Proteobacteria,2UQAG@28211|Alphaproteobacteria,1JNC4@119043|Rhodobiaceae	28211|Alphaproteobacteria	V	ABC transporter transmembrane region	atm1	GO:0003674,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0006996,GO:0007275,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009507,GO:0009526,GO:0009536,GO:0009555,GO:0009657,GO:0009658,GO:0009889,GO:0009941,GO:0009987,GO:0010035,GO:0010038,GO:0010288,GO:0010380,GO:0016020,GO:0016043,GO:0018130,GO:0019222,GO:0019538,GO:0019637,GO:0019720,GO:0019725,GO:0019866,GO:0022622,GO:0030003,GO:0031090,GO:0031323,GO:0031326,GO:0031966,GO:0031967,GO:0031975,GO:0032501,GO:0032502,GO:0042221,GO:0042592,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044429,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046483,GO:0046686,GO:0046916,GO:0048229,GO:0048364,GO:0048731,GO:0048856,GO:0048878,GO:0050789,GO:0050790,GO:0050794,GO:0050801,GO:0050896,GO:0051171,GO:0051186,GO:0051188,GO:0051189,GO:0051193,GO:0051276,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0065009,GO:0071704,GO:0071840,GO:0090056,GO:0090407,GO:0098771,GO:0099402,GO:1901360,GO:1901362,GO:1901401,GO:1901463,GO:1901564,GO:1901566,GO:1901576	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
SHD2_k127_1131556_1	402881.Plav_0170	0.0	1062.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,1JNA3@119043|Rhodobiaceae	28211|Alphaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	ttgE	-	-	ko:K18989	-	M00720	-	-	ko00000,ko00002,ko02000	2.A.6.2.30	-	-	ACR_tran
SHD2_k127_1131556_60	402881.Plav_0171	3.336e-87	301.0	COG0845@1|root,COG0845@2|Bacteria,1MVFN@1224|Proteobacteria,2TRSC@28211|Alphaproteobacteria,1JNK6@119043|Rhodobiaceae	28211|Alphaproteobacteria	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	-	-	-	ko:K18990	-	M00720	-	-	ko00000,ko00002,ko02000	2.A.6.2.30,8.A.1	-	-	Biotin_lipoyl_2,HlyD_D23
SHD2_k127_1131556_94	1333998.M2A_2326	4.535e-45	171.0	COG1695@1|root,COG1695@2|Bacteria,1N33P@1224|Proteobacteria,2U9ZC@28211|Alphaproteobacteria,4BSCC@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
SHD2_k127_1131556_95	1121033.AUCF01000006_gene4346	8.34e-45	171.0	COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,2U8YK@28211|Alphaproteobacteria,2JT2R@204441|Rhodospirillales	204441|Rhodospirillales	K	Cold shock protein domain	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
SHD2_k127_1131556_57	1121957.ATVL01000008_gene4422	1.762e-89	304.0	COG2267@1|root,COG2267@2|Bacteria,4PKB6@976|Bacteroidetes,47JMT@768503|Cytophagia	976|Bacteroidetes	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
SHD2_k127_1131556_24	402881.Plav_2485	3.675e-154	497.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2TR6Q@28211|Alphaproteobacteria,1JNCZ@119043|Rhodobiaceae	28211|Alphaproteobacteria	L	DEAD-like helicases superfamily	rhlE	-	3.6.4.13	ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DEAD,Helicase_C
SHD2_k127_1131556_83	1282876.BAOK01000001_gene2452	6.789e-59	207.0	COG1671@1|root,COG1671@2|Bacteria,1RCZA@1224|Proteobacteria,2U997@28211|Alphaproteobacteria,4BQMT@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Uncharacterized BCR, YaiI/YqxD family COG1671	MA20_27470	-	-	ko:K09768	-	-	-	-	ko00000	-	-	-	DUF188
SHD2_k127_1131556_39	1207063.P24_07784	1.148e-117	385.0	COG2175@1|root,COG2175@2|Bacteria,1MV5K@1224|Proteobacteria,2TQTZ@28211|Alphaproteobacteria,2JSGW@204441|Rhodospirillales	204441|Rhodospirillales	Q	Taurine catabolism dioxygenase TauD, TfdA family	tauD	-	1.14.11.17	ko:K03119,ko:K22303	ko00430,ko00920,map00430,map00920	-	R05320	RC01331	ko00000,ko00001,ko01000	-	-	-	TauD
SHD2_k127_1131556_102	1382303.JPOM01000001_gene141	1.026e-39	156.0	COG0625@1|root,COG0625@2|Bacteria,1Q1HA@1224|Proteobacteria,2UDXD@28211|Alphaproteobacteria,2KIXM@204458|Caulobacterales	204458|Caulobacterales	O	Glutathione S-transferase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	GST_C_2,GST_N_3
SHD2_k127_1131556_7	1298858.AUEL01000012_gene5119	3.538e-247	777.0	COG0514@1|root,COG0514@2|Bacteria,1MVGG@1224|Proteobacteria,2TS8B@28211|Alphaproteobacteria,43GZK@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	L	DNA helicase	recQ	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,HRDC,Helicase_C,RQC,RecQ_Zn_bind
SHD2_k127_1131556_46	450851.PHZ_c2467	1.377e-107	355.0	COG3386@1|root,COG3386@2|Bacteria,1MWTR@1224|Proteobacteria,2TV5X@28211|Alphaproteobacteria,2KGD5@204458|Caulobacterales	204458|Caulobacterales	G	Gluconolaconase	-	-	-	ko:K14274	ko00040,map00040	-	R02427	RC00713	ko00000,ko00001,ko01000	-	-	-	SGL
SHD2_k127_1131556_3	573065.Astex_1909	1.511e-313	968.0	COG0129@1|root,COG0129@2|Bacteria,1MV4I@1224|Proteobacteria,2TQRW@28211|Alphaproteobacteria,2KFMP@204458|Caulobacterales	204458|Caulobacterales	EG	Belongs to the IlvD Edd family	-	-	4.2.1.82	ko:K22186	ko00040,map00040	-	R02429	RC00543	ko00000,ko00001,ko01000	-	-	-	ILVD_EDD
SHD2_k127_1131556_45	518766.Rmar_1392	5.119e-111	394.0	COG2317@1|root,COG2317@2|Bacteria,4NK5Q@976|Bacteroidetes,1FISH@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	E	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues	-	-	3.4.17.19	ko:K01299	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M32
SHD2_k127_1131556_9	118161.KB235922_gene1210	3.823e-237	743.0	COG2072@1|root,COG2072@2|Bacteria,1G8W3@1117|Cyanobacteria	1117|Cyanobacteria	C	Flavin-binding monooxygenase-like	-	-	-	-	-	-	-	-	-	-	-	-	FMO-like
SHD2_k127_1131556_79	463191.SSEG_06684	1.851e-66	234.0	COG1028@1|root,COG1028@2|Bacteria,2I6UQ@201174|Actinobacteria	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
SHD2_k127_1131556_130	1038866.KB902786_gene2877	8.307e-07	55.0	COG0318@1|root,COG0318@2|Bacteria,1MWF2@1224|Proteobacteria,2TU4I@28211|Alphaproteobacteria,3JR3C@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	6.2.1.48	ko:K02182	-	-	-	-	ko00000,ko01000	-	-	-	AMP-binding,AMP-binding_C
SHD2_k127_1131556_127	319003.Bra1253DRAFT_04805	7.106e-09	60.0	COG0318@1|root,COG0318@2|Bacteria,1MWF2@1224|Proteobacteria,2TU4I@28211|Alphaproteobacteria,3JR3C@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	6.2.1.48	ko:K02182	-	-	-	-	ko00000,ko01000	-	-	-	AMP-binding,AMP-binding_C
SHD2_k127_1131556_77	1429916.X566_09800	2.771e-68	233.0	COG3791@1|root,COG3791@2|Bacteria,1RAJQ@1224|Proteobacteria,2U5ME@28211|Alphaproteobacteria,3JY8E@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Glutathione-dependent formaldehyde-activating enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GFA
SHD2_k127_1131556_21	1206731.BAGB01000167_gene910	1.313e-157	512.0	COG0183@1|root,COG1024@1|root,COG0183@2|Bacteria,COG1024@2|Bacteria,2GKJ6@201174|Actinobacteria,4FZWC@85025|Nocardiaceae	201174|Actinobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	2.3.1.9,4.2.1.149	ko:K00626,ko:K08299	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177,R10675	RC00004,RC00326,RC01095	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ECH_1
SHD2_k127_1131556_35	228405.HNE_2749	1.242e-130	421.0	COG1024@1|root,COG1024@2|Bacteria,1P5FE@1224|Proteobacteria,2U1TI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
SHD2_k127_1131556_129	3988.XP_002538431.1	4.57e-07	55.0	COG0183@1|root,KOG1389@2759|Eukaryota	2759|Eukaryota	I	acetyl-CoA C-acyltransferase activity	-	-	1.1.1.211,1.1.1.35,2.3.1.16,4.2.1.17	ko:K07513,ko:K10527	ko00071,ko00280,ko00592,ko01040,ko01100,ko01110,ko01130,ko01212,ko03320,ko04146,map00071,map00280,map00592,map01040,map01100,map01110,map01130,map01212,map03320,map04146	M00087,M00113	R00927,R01177,R01975,R03026,R03778,R03858,R03991,R04170,R04546,R04737,R04738,R04739,R04740,R04741,R04742,R04743,R04744,R04745,R04746,R04747,R04748,R04749,R07889,R07890,R07891,R07893,R07894,R07895,R07897,R07898,R07899,R07937,R07953	RC00004,RC00029,RC00117,RC00326,RC00405,RC00831,RC01095,RC01702,RC02728	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1,Pkinase_Tyr,Thiolase_C,Thiolase_N
SHD2_k127_1131556_37	366602.Caul_3873	3.614e-127	419.0	COG1960@1|root,COG1960@2|Bacteria,1MXE3@1224|Proteobacteria,2U36A@28211|Alphaproteobacteria,2KHZC@204458|Caulobacterales	204458|Caulobacterales	C	Acyl-CoA dehydrogenase, middle domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
SHD2_k127_1131556_69	258594.RPA0108	3.401e-74	254.0	COG0028@1|root,COG0028@2|Bacteria,1MXDW@1224|Proteobacteria,2TT9X@28211|Alphaproteobacteria,3JRKI@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EH	Belongs to the TPP enzyme family	MA20_15075	-	2.2.1.6,4.1.1.8	ko:K01577,ko:K01652	ko00290,ko00630,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00630,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R01908,R03050,R04672,R04673,R08648	RC00027,RC00106,RC00620,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
SHD2_k127_1131556_88	2055.JNXA01000025_gene4129	4.353e-50	190.0	COG0028@1|root,COG0028@2|Bacteria,2GM6Y@201174|Actinobacteria,4GDMS@85026|Gordoniaceae	201174|Actinobacteria	EH	Thiamine pyrophosphate enzyme, central domain	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
SHD2_k127_1131556_87	258594.RPA0108	2.032e-50	182.0	COG0028@1|root,COG0028@2|Bacteria,1MXDW@1224|Proteobacteria,2TT9X@28211|Alphaproteobacteria,3JRKI@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EH	Belongs to the TPP enzyme family	MA20_15075	-	2.2.1.6,4.1.1.8	ko:K01577,ko:K01652	ko00290,ko00630,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00630,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R01908,R03050,R04672,R04673,R08648	RC00027,RC00106,RC00620,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
SHD2_k127_1131556_67	756272.Plabr_0478	1.022e-76	268.0	COG2382@1|root,COG2382@2|Bacteria,2IWXM@203682|Planctomycetes	203682|Planctomycetes	P	esterase	-	-	-	ko:K07214	-	-	-	-	ko00000	-	-	-	Esterase
SHD2_k127_1131556_73	1380394.JADL01000003_gene5128	1.728e-71	253.0	COG1560@1|root,COG1560@2|Bacteria,1MVNI@1224|Proteobacteria,2TS2H@28211|Alphaproteobacteria,2JQV6@204441|Rhodospirillales	204441|Rhodospirillales	M	COG1560 Lauroyl myristoyl acyltransferase	-	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
SHD2_k127_1131556_101	1380394.JADL01000001_gene2232	1.952e-40	160.0	COG0575@1|root,COG0575@2|Bacteria,1N4I3@1224|Proteobacteria,2U7WC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	CDP-archaeol synthase	-	-	2.7.7.67	ko:K19664	ko00564,map00564	-	R08966	RC00002	ko00000,ko00001,ko01000	-	-	-	CarS-like
SHD2_k127_1131556_34	1040989.AWZU01000004_gene7186	1.793e-135	439.0	COG1408@1|root,COG1408@2|Bacteria,1MUH5@1224|Proteobacteria,2U0JR@28211|Alphaproteobacteria,3JWTF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos,Metallophos_2
SHD2_k127_1131556_85	224911.27352916	1.496e-56	205.0	COG0778@1|root,COG0778@2|Bacteria,1PEMB@1224|Proteobacteria,2V61J@28211|Alphaproteobacteria,3JYA5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
SHD2_k127_1131556_96	670307.HYPDE_23258	9.587e-45	175.0	COG0517@1|root,COG0517@2|Bacteria,1Q3MP@1224|Proteobacteria,2UB19@28211|Alphaproteobacteria,3N8JD@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
SHD2_k127_1131556_111	56107.Cylst_2967	7.809e-29	128.0	COG5502@1|root,COG5502@2|Bacteria,1G7AK@1117|Cyanobacteria,1HN9D@1161|Nostocales	1117|Cyanobacteria	S	Uncharacterized conserved protein (DUF2267)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2267
SHD2_k127_1131556_93	395963.Bind_0545	7.747e-47	175.0	COG1278@1|root,COG1278@2|Bacteria,1QW5N@1224|Proteobacteria,2U8SB@28211|Alphaproteobacteria,3NBDP@45404|Beijerinckiaceae	28211|Alphaproteobacteria	K	Sigma 54 modulation protein / S30EA ribosomal protein	-	-	-	-	-	-	-	-	-	-	-	-	CSD,Ribosomal_S30AE
SHD2_k127_1131556_108	1125973.JNLC01000011_gene527	8.978e-34	136.0	COG5622@1|root,COG5622@2|Bacteria,1RIEJ@1224|Proteobacteria,2U7UE@28211|Alphaproteobacteria,3JVUA@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	N	Protein required for attachment to host cells	MA20_35675	-	-	-	-	-	-	-	-	-	-	-	Host_attach
SHD2_k127_1131556_99	392499.Swit_1147	2.571e-44	166.0	COG0071@1|root,COG0071@2|Bacteria,1N0RH@1224|Proteobacteria,2UE1E@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Belongs to the small heat shock protein (HSP20) family	MA20_45160	-	-	-	-	-	-	-	-	-	-	-	HSP20
SHD2_k127_1131556_2	648757.Rvan_2706	0.0	1017.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,2U0IK@28211|Alphaproteobacteria,3N7R1@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	MA20_45155	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
SHD2_k127_1131556_121	1301098.PKB_4231	2.662e-16	86.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,1RNHN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
SHD2_k127_1131556_105	926550.CLDAP_19190	1.384e-36	144.0	COG0365@1|root,COG0365@2|Bacteria,2G5KE@200795|Chloroflexi	2|Bacteria	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
SHD2_k127_1131556_64	395964.KE386496_gene2822	3.006e-78	267.0	COG1926@1|root,COG1926@2|Bacteria,1RAG8@1224|Proteobacteria,2U5HS@28211|Alphaproteobacteria,3NAXQ@45404|Beijerinckiaceae	28211|Alphaproteobacteria	S	Phosphoribosyl transferase domain	-	-	-	ko:K07100	-	-	-	-	ko00000	-	-	-	Erythro_esteras,Pribosyltran
SHD2_k127_1131556_70	663610.JQKO01000005_gene2458	6.058e-73	252.0	COG1073@1|root,COG1073@2|Bacteria,1RDAY@1224|Proteobacteria,2U5QZ@28211|Alphaproteobacteria,3NB5N@45404|Beijerinckiaceae	28211|Alphaproteobacteria	S	Dienelactone hydrolase family	-	-	-	ko:K07100	-	-	-	-	ko00000	-	-	-	DLH,Pribosyltran
SHD2_k127_1131556_120	1532558.JL39_04440	4.345e-18	85.0	COG4572@1|root,COG4572@2|Bacteria,1N93H@1224|Proteobacteria,2UHM8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	ChaB	chaB	-	-	ko:K06197	-	-	-	-	ko00000	-	-	-	ChaB
SHD2_k127_1131556_12	472759.Nhal_1958	1.338e-208	664.0	COG1387@1|root,COG1796@1|root,COG1387@2|Bacteria,COG1796@2|Bacteria,1MYXV@1224|Proteobacteria,1TK7U@1236|Gammaproteobacteria,1X089@135613|Chromatiales	135613|Chromatiales	L	DNA polymerase X family	-	-	-	ko:K02347	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_palm,DNA_pol_B_thumb,HHH_5,HHH_8
SHD2_k127_1131556_59	1333998.M2A_2312	3.104e-88	303.0	COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,2TT2C@28211|Alphaproteobacteria,4BRSY@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	FP	Ppx/GppA phosphatase family	ppx	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	Ppx-GppA
SHD2_k127_1131556_65	1122132.AQYH01000018_gene1164	4.124e-78	274.0	COG0293@1|root,COG0293@2|Bacteria,1MW1C@1224|Proteobacteria,2TSBW@28211|Alphaproteobacteria,4B72X@82115|Rhizobiaceae	28211|Alphaproteobacteria	J	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit	ftsJ	-	2.1.1.166	ko:K02427	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ
SHD2_k127_1131556_103	1205680.CAKO01000030_gene4866	4.139e-39	153.0	2CPI3@1|root,32SJ7@2|Bacteria,1N1IR@1224|Proteobacteria,2UBVS@28211|Alphaproteobacteria,2JX60@204441|Rhodospirillales	204441|Rhodospirillales	S	Protein of unknown function (DUF992)	-	-	-	-	-	-	-	-	-	-	-	-	DUF992
SHD2_k127_1131556_8	1121033.AUCF01000001_gene2085	1.707e-238	745.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,2TQXC@28211|Alphaproteobacteria,2JPJW@204441|Rhodospirillales	204441|Rhodospirillales	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH,NMO
SHD2_k127_1131556_66	1122604.JONR01000023_gene4137	6.279e-77	265.0	COG0428@1|root,COG0428@2|Bacteria	2|Bacteria	P	transporter	-	-	-	ko:K07238,ko:K11021	-	-	-	-	ko00000,ko02000,ko02042	2.A.5.5	-	-	Zip
SHD2_k127_1131556_53	1380355.JNIJ01000036_gene4942	1.086e-96	332.0	COG0144@1|root,COG0144@2|Bacteria,1MV2Q@1224|Proteobacteria,2TS6U@28211|Alphaproteobacteria,3JTMA@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family	sun1	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F
SHD2_k127_1131556_5	1121033.AUCF01000001_gene2344	2.14e-261	812.0	COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,2TRN0@28211|Alphaproteobacteria,2JPER@204441|Rhodospirillales	204441|Rhodospirillales	F	Catalyzes the synthesis of GMP from XMP	guaA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
SHD2_k127_1131556_126	1089552.KI911559_gene888	1.31e-09	65.0	COG5388@1|root,COG5388@2|Bacteria,1N0UI@1224|Proteobacteria,2UCZU@28211|Alphaproteobacteria,2JTNR@204441|Rhodospirillales	204441|Rhodospirillales	S	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	PAS_5
SHD2_k127_1131556_113	1282360.ABAC460_22810	7.014e-27	115.0	COG2261@1|root,COG2261@2|Bacteria,1N72Y@1224|Proteobacteria,2UFM5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	PFAM Transglycosylase-associated protein	MA20_19350	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
SHD2_k127_1131556_23	438753.AZC_0530	1.583e-155	506.0	COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,2TSF9@28211|Alphaproteobacteria,3EYTS@335928|Xanthobacteraceae	28211|Alphaproteobacteria	L	it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins	dnaB	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
SHD2_k127_1131556_54	1207063.P24_04095	6.458e-92	316.0	COG0787@1|root,COG0787@2|Bacteria,1MV0Q@1224|Proteobacteria,2TQKD@28211|Alphaproteobacteria,2JPXT@204441|Rhodospirillales	204441|Rhodospirillales	M	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
SHD2_k127_1131556_47	402881.Plav_3483	8.777e-107	357.0	COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,2TSGS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	ABC-type transport system involved in resistance to organic solvents permease component	mlaE	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
SHD2_k127_1131556_41	414684.RC1_1580	1.167e-116	395.0	COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,2TR2I@28211|Alphaproteobacteria,2JQ66@204441|Rhodospirillales	204441|Rhodospirillales	Q	COG1127 ABC-type transport system involved in resistance to organic solvents, ATPase component	mkl	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
SHD2_k127_1131556_16	402881.Plav_3485	3.851e-179	571.0	COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,2TS6F@28211|Alphaproteobacteria,1JNAS@119043|Rhodobiaceae	28211|Alphaproteobacteria	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	AAA_25,ATPase,ChlI
SHD2_k127_1131556_115	1333998.M2A_2273	1.562e-24	111.0	COG1286@1|root,COG1286@2|Bacteria,1NF4G@1224|Proteobacteria,2TUVR@28211|Alphaproteobacteria,4BR3E@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Colicin V production protein	cvpA	-	-	ko:K03558	-	-	-	-	ko00000	-	-	-	Colicin_V
SHD2_k127_1131556_13	331869.BAL199_23487	3.44e-203	642.0	COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,2TR8V@28211|Alphaproteobacteria,4BPVI@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009536,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
SHD2_k127_1131556_61	1333998.M2A_2275	8.058e-86	292.0	COG1028@1|root,COG1028@2|Bacteria,1MWBC@1224|Proteobacteria,2TTQS@28211|Alphaproteobacteria,4BPZQ@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	IQ	KR domain	MA20_27940	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0008150,GO:0008152,GO:0009056,GO:0016491,GO:0044464,GO:0055114,GO:0071704,GO:1901575	-	-	-	-	-	-	-	-	-	-	adh_short
SHD2_k127_1131556_86	1205680.CAKO01000038_gene1961	3.872e-56	207.0	COG1024@1|root,COG1024@2|Bacteria,1RG4N@1224|Proteobacteria,2U8TJ@28211|Alphaproteobacteria,2JWTN@204441|Rhodospirillales	204441|Rhodospirillales	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
SHD2_k127_1131556_20	1211115.ALIQ01000021_gene4543	2.547e-160	517.0	COG1160@1|root,COG1160@2|Bacteria,1MU9S@1224|Proteobacteria,2TT38@28211|Alphaproteobacteria,3N9JX@45404|Beijerinckiaceae	28211|Alphaproteobacteria	S	KH-domain-like of EngA bacterial GTPase enzymes, C-terminal	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
SHD2_k127_1131556_25	402881.Plav_3493	5.113e-152	498.0	COG1520@1|root,COG1520@2|Bacteria,1MXIJ@1224|Proteobacteria,2TUAD@28211|Alphaproteobacteria,1JNN6@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	PQQ-like domain	bamB	-	-	ko:K17713	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	PQQ_2,PQQ_3
SHD2_k127_1131556_110	1125973.JNLC01000016_gene2987	4.85e-29	127.0	COG4649@1|root,COG4649@2|Bacteria,1P2GI@1224|Proteobacteria,2UCFZ@28211|Alphaproteobacteria,3JS1T@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Tetratricopeptide repeat-like domain	-	-	-	-	-	-	-	-	-	-	-	-	TPR_21
SHD2_k127_1131556_36	402881.Plav_3495	8.861e-128	413.0	COG0413@1|root,COG0413@2|Bacteria,1MU3B@1224|Proteobacteria,2TQT1@28211|Alphaproteobacteria,1JNC7@119043|Rhodobiaceae	28211|Alphaproteobacteria	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
SHD2_k127_1131556_123	153948.NAL212_2274	1.056e-13	76.0	COG0346@1|root,COG0346@2|Bacteria,1RI3Q@1224|Proteobacteria,2VSN7@28216|Betaproteobacteria,3734X@32003|Nitrosomonadales	28216|Betaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
SHD2_k127_1131556_82	1120956.JHZK01000001_gene3207	1.739e-62	220.0	COG0359@1|root,COG0359@2|Bacteria,1RD0R@1224|Proteobacteria,2TSC9@28211|Alphaproteobacteria,1JNXQ@119043|Rhodobiaceae	28211|Alphaproteobacteria	J	Ribosomal protein L9, N-terminal domain	rplI	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
SHD2_k127_1131556_106	1238182.C882_4558	1.876e-34	134.0	COG0238@1|root,COG0238@2|Bacteria,1MZ8U@1224|Proteobacteria,2UC13@28211|Alphaproteobacteria,2JT7Q@204441|Rhodospirillales	204441|Rhodospirillales	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit	rpsR	-	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
SHD2_k127_1131556_104	663610.JQKO01000008_gene185	7.801e-37	144.0	COG0360@1|root,COG0360@2|Bacteria,1RH82@1224|Proteobacteria,2U767@28211|Alphaproteobacteria,3NB0C@45404|Beijerinckiaceae	28211|Alphaproteobacteria	J	rRNA binding	rpsF	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0097159,GO:1901363,GO:1990904	-	ko:K02990	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S6
SHD2_k127_1131556_28	1131814.JAFO01000001_gene4060	4.578e-148	481.0	COG2271@1|root,COG2271@2|Bacteria,1MUEK@1224|Proteobacteria,2TS60@28211|Alphaproteobacteria,3F0TF@335928|Xanthobacteraceae	28211|Alphaproteobacteria	G	Major Facilitator Superfamily	-	-	-	ko:K13021	-	-	-	-	ko00000,ko02000	2.A.1.14.3	-	-	MFS_1
SHD2_k127_1131556_40	402881.Plav_3360	2.085e-117	385.0	COG0331@1|root,COG0331@2|Bacteria,1MV6N@1224|Proteobacteria,2TRTT@28211|Alphaproteobacteria,1JN57@119043|Rhodobiaceae	28211|Alphaproteobacteria	I	Acyl transferase domain	fabD	GO:0003674,GO:0003824,GO:0004312,GO:0004314,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016417,GO:0016419,GO:0016420,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
SHD2_k127_1131556_52	1121271.AUCM01000003_gene1456	2.092e-98	339.0	COG1028@1|root,COG1028@2|Bacteria,1MU6X@1224|Proteobacteria,2TQZG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	fabG	GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
SHD2_k127_1131556_107	1116369.KB890024_gene1474	2.704e-34	134.0	COG0236@1|root,COG0236@2|Bacteria,1MZ4P@1224|Proteobacteria,2UBWW@28211|Alphaproteobacteria,43KPN@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
SHD2_k127_1131556_14	1333998.M2A_1182	2.365e-200	631.0	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,2TR32@28211|Alphaproteobacteria,4BPJX@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
SHD2_k127_1131556_56	1122613.ATUP01000002_gene2521	6.484e-91	316.0	COG1559@1|root,COG1559@2|Bacteria,1MUQF@1224|Proteobacteria,2TR89@28211|Alphaproteobacteria,43WJG@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
SHD2_k127_1131556_63	402881.Plav_3355	3.615e-79	274.0	COG1561@1|root,COG1561@2|Bacteria,1MWRA@1224|Proteobacteria,2TS81@28211|Alphaproteobacteria,1JNYY@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DUF1732)	yicC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	DUF1732,YicC_N
SHD2_k127_1131556_68	1122135.KB893169_gene2438	1.961e-74	255.0	COG0194@1|root,COG0194@2|Bacteria,1MW92@1224|Proteobacteria,2TSCQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	F	Essential for recycling GMP and indirectly, cGMP	gmk	GO:0003674,GO:0003824,GO:0004385,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
SHD2_k127_1131556_33	1033802.SSPSH_000686	2.598e-139	451.0	COG3618@1|root,COG3618@2|Bacteria,1MVG0@1224|Proteobacteria,1RRC6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
SHD2_k127_1131556_29	402881.Plav_3345	2.094e-147	474.0	COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,2TTYY@28211|Alphaproteobacteria,1JP0W@119043|Rhodobiaceae	28211|Alphaproteobacteria	C	Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.1	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
SHD2_k127_1131556_48	1333998.M2A_1173	8.883e-107	352.0	COG0030@1|root,COG0030@2|Bacteria,1MVNU@1224|Proteobacteria,2TRD9@28211|Alphaproteobacteria,4BQ10@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
SHD2_k127_1131556_58	349163.Acry_2630	2.542e-89	306.0	COG1995@1|root,COG1995@2|Bacteria,1MX5W@1224|Proteobacteria,2TSKF@28211|Alphaproteobacteria,2JPW9@204441|Rhodospirillales	204441|Rhodospirillales	H	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)	pdxA	-	1.1.1.262	ko:K00097	ko00750,ko01100,map00750,map01100	M00124	R05681,R05837,R07406	RC00089,RC00675,RC01475	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxA
SHD2_k127_1131556_72	509190.Cseg_2292	9.149e-72	261.0	COG0760@1|root,COG0760@2|Bacteria,1MVB3@1224|Proteobacteria,2TSJ3@28211|Alphaproteobacteria,2KFBX@204458|Caulobacterales	204458|Caulobacterales	M	Chaperone SurA	-	-	5.2.1.8	ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,SurA_N,SurA_N_3
SHD2_k127_1131556_32	402881.Plav_3340	2.597e-140	477.0	COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,2TR3B@28211|Alphaproteobacteria,1JNIF@119043|Rhodobiaceae	28211|Alphaproteobacteria	M	Involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane	lptD	-	-	ko:K04744	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA,OstA_C
SHD2_k127_1131556_51	1282876.BAOK01000001_gene2394	1.555e-98	338.0	COG0795@1|root,COG0795@2|Bacteria,1MVW3@1224|Proteobacteria,2TR76@28211|Alphaproteobacteria,4BQ5H@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Predicted permease YjgP/YjgQ family	lptG	-	-	ko:K11720	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
SHD2_k127_1131556_76	1333998.M2A_1168	2.758e-68	246.0	COG0795@1|root,COG0795@2|Bacteria,1MUF2@1224|Proteobacteria,2TQUB@28211|Alphaproteobacteria,4BQ7P@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Predicted permease YjgP/YjgQ family	MA20_28210	-	-	ko:K07091	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
SHD2_k127_1131556_17	1244869.H261_09227	1.852e-172	557.0	COG0260@1|root,COG0260@2|Bacteria,1MUF9@1224|Proteobacteria,2TQU9@28211|Alphaproteobacteria,2JPEV@204441|Rhodospirillales	204441|Rhodospirillales	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
SHD2_k127_1131556_90	402881.Plav_3336	7.05e-48	183.0	COG2927@1|root,COG2927@2|Bacteria,1RGVC@1224|Proteobacteria,2U94V@28211|Alphaproteobacteria,1JP1R@119043|Rhodobiaceae	28211|Alphaproteobacteria	L	DNA polymerase III chi subunit, HolC	holC	-	2.7.7.7	ko:K02339	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_chi
SHD2_k127_1131556_89	317013.NY99_04140	1.284e-48	184.0	COG4700@1|root,COG4700@2|Bacteria,1R577@1224|Proteobacteria,1S5I8@1236|Gammaproteobacteria,1X5VW@135614|Xanthomonadales	135614|Xanthomonadales	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_19
SHD2_k127_1131556_15	1122132.AQYH01000010_gene3957	2.7e-199	640.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2TQRZ@28211|Alphaproteobacteria,4B71Q@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	ATPase components of ABC transporters with duplicated ATPase domains	yheS	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
SHD2_k127_1131556_42	1120797.KB908262_gene2997	2.016e-116	382.0	COG3386@1|root,COG3386@2|Bacteria	2|Bacteria	G	gluconolactonase activity	-	-	3.1.1.17	ko:K01053	ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02933,R03751	RC00537,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Esterase,SGL
SHD2_k127_1131556_80	1220535.IMCC14465_02450	1.743e-64	222.0	COG0105@1|root,COG0105@2|Bacteria,1R9ZA@1224|Proteobacteria,2U5CS@28211|Alphaproteobacteria,4BQ4S@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:0072521,GO:0072527,GO:1901360,GO:1901564	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
SHD2_k127_1131556_62	1192034.CAP_3537	4.19e-82	282.0	COG1028@1|root,COG1028@2|Bacteria,1P9R4@1224|Proteobacteria,42TE9@68525|delta/epsilon subdivisions,2WPGF@28221|Deltaproteobacteria,2YUH5@29|Myxococcales	28221|Deltaproteobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
SHD2_k127_1131556_71	1333998.M2A_1161	5.625e-72	250.0	COG0299@1|root,COG0299@2|Bacteria,1MWN1@1224|Proteobacteria,2TRY6@28211|Alphaproteobacteria,4BQ3T@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	purN	GO:0003674,GO:0003824,GO:0004644,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016740,GO:0016741,GO:0016742,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	Formyl_trans_N,YjbR
SHD2_k127_1131556_31	1410620.SHLA_62c000400	1.369e-141	460.0	COG0150@1|root,COG0150@2|Bacteria,1MURG@1224|Proteobacteria,2TR6G@28211|Alphaproteobacteria,4BA4V@82115|Rhizobiaceae	28211|Alphaproteobacteria	F	Phosphoribosylformylglycinamidine cyclo-ligase	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
SHD2_k127_1131556_43	1229204.AMYY01000017_gene1337	6.699e-115	385.0	COG5267@1|root,COG5267@2|Bacteria,1MWJK@1224|Proteobacteria,2TSY7@28211|Alphaproteobacteria,4BQBP@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1800)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1800
SHD2_k127_1131556_49	1040989.AWZU01000001_gene5768	1.014e-102	349.0	COG4102@1|root,COG4102@2|Bacteria,1MX4R@1224|Proteobacteria,2TSFB@28211|Alphaproteobacteria,3JRCB@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1501)	MA20_05265	-	-	-	-	-	-	-	-	-	-	-	DUF1501
SHD2_k127_1131556_109	1333998.M2A_1159	3.086e-31	136.0	COG3249@1|root,COG3249@2|Bacteria,1RE2R@1224|Proteobacteria,2U7HJ@28211|Alphaproteobacteria,4BSTJ@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2066)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2066
SHD2_k127_1131556_112	1187851.A33M_2405	5.849e-28	124.0	COG0558@1|root,COG0558@2|Bacteria,1MZ8B@1224|Proteobacteria,2U7AP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	MA20_28295	-	2.7.8.41,2.7.8.5	ko:K00995,ko:K08744	ko00564,ko01100,map00564,map01100	-	R01801,R02030	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
SHD2_k127_1131556_100	1333998.M2A_1156	4.957e-44	168.0	COG0593@1|root,COG0593@2|Bacteria,1N4PG@1224|Proteobacteria,2U96K@28211|Alphaproteobacteria,4BQH5@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	L	Belongs to the DnaA family	hda	-	-	-	-	-	-	-	-	-	-	-	Bac_DnaA
SHD2_k127_1131556_4	936455.KI421499_gene3203	4.978e-297	928.0	COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,2TRBP@28211|Alphaproteobacteria,3JTTT@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
SHD2_k127_1131556_38	402881.Plav_3325	3.193e-125	417.0	COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,2TR1W@28211|Alphaproteobacteria,1JNCJ@119043|Rhodobiaceae	28211|Alphaproteobacteria	FP	Ppx/GppA phosphatase family	ppx	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	Ppx-GppA
SHD2_k127_1131556_122	426355.Mrad2831_2764	1.078e-14	78.0	COG1826@1|root,COG1826@2|Bacteria,1NGDP@1224|Proteobacteria,2UFBN@28211|Alphaproteobacteria,1JVIR@119045|Methylobacteriaceae	28211|Alphaproteobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	tatA	GO:0003674,GO:0005215	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
SHD2_k127_1131556_118	588932.JHOF01000018_gene880	4.985e-20	94.0	COG1826@1|root,COG1826@2|Bacteria,1N73F@1224|Proteobacteria,2UF4Z@28211|Alphaproteobacteria,2KH39@204458|Caulobacterales	204458|Caulobacterales	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation	tatB	-	-	ko:K03117	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
SHD2_k127_1131556_55	1380394.JADL01000005_gene5651	3.503e-91	309.0	COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,2TTIX@28211|Alphaproteobacteria,2JPBF@204441|Rhodospirillales	204441|Rhodospirillales	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
SHD2_k127_1131556_26	69395.JQLZ01000001_gene2653	8.106e-152	496.0	COG0172@1|root,COG0172@2|Bacteria,1MUJF@1224|Proteobacteria,2TR4T@28211|Alphaproteobacteria,2KFZC@204458|Caulobacterales	204458|Caulobacterales	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
SHD2_k127_1131556_50	1282876.BAOK01000001_gene2037	3.593e-100	332.0	COG0496@1|root,COG0496@2|Bacteria,1MVHE@1224|Proteobacteria,2TQXZ@28211|Alphaproteobacteria,4BQ5E@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates	surE	-	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	SurE
SHD2_k127_1131556_78	1430440.MGMSRv2_1049	1.283e-67	243.0	COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,2TVCY@28211|Alphaproteobacteria,2JRV7@204441|Rhodospirillales	204441|Rhodospirillales	J	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
SHD2_k127_1131556_92	335659.S23_34220	2.1e-47	178.0	COG0739@1|root,COG1388@1|root,COG0739@2|Bacteria,COG1388@2|Bacteria,1QV29@1224|Proteobacteria,2TW8Q@28211|Alphaproteobacteria,3JTS0@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Lysin motif	lysM	-	-	-	-	-	-	-	-	-	-	-	LysM,Peptidase_M23
SHD2_k127_1131556_44	1144343.PMI41_00598	1.032e-114	376.0	COG2607@1|root,COG2607@2|Bacteria,1MVMX@1224|Proteobacteria,2TTFE@28211|Alphaproteobacteria,43H6D@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	ATPase (AAA	MA20_41470	-	-	ko:K06923	-	-	-	-	ko00000	-	-	-	DUF815
SHD2_k127_1131556_116	402881.Plav_3035	1.584e-23	107.0	COG1862@1|root,COG1862@2|Bacteria,1MZT2@1224|Proteobacteria,2UBZ6@28211|Alphaproteobacteria,1JP8C@119043|Rhodobiaceae	28211|Alphaproteobacteria	U	Preprotein translocase subunit	yajC	-	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
SHD2_k127_1131556_19	1122214.AQWH01000030_gene4895	4.953e-165	535.0	COG0341@1|root,COG0342@1|root,COG0341@2|Bacteria,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,2TQYG@28211|Alphaproteobacteria,2PJH3@255475|Aurantimonadaceae	28211|Alphaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072,ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
SHD2_k127_1131556_74	402881.Plav_3039	3.416e-71	246.0	COG3748@1|root,COG3748@2|Bacteria,1RFIZ@1224|Proteobacteria,2U7B1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Urate oxidase N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Urate_ox_N
SHD2_k127_1131556_84	402881.Plav_3040	1.741e-58	213.0	COG1562@1|root,COG1562@2|Bacteria,1MX4W@1224|Proteobacteria,2U08T@28211|Alphaproteobacteria,1JPAW@119043|Rhodobiaceae	28211|Alphaproteobacteria	I	Squalene/phytoene synthase	crtB	-	2.5.1.32,2.5.1.99	ko:K02291,ko:K18163	ko00906,ko01062,ko01100,ko01110,ko04714,map00906,map01062,map01100,map01110,map04714	M00097	R02065,R04218,R07270,R10177	RC00362,RC01101,RC02869	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	SQS_PSY
SHD2_k127_1131556_11	1205680.CAKO01000029_gene5143	9.267e-213	669.0	COG1206@1|root,COG1206@2|Bacteria,1MWNQ@1224|Proteobacteria,2TR6M@28211|Alphaproteobacteria,2JQ17@204441|Rhodospirillales	204441|Rhodospirillales	J	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs	trmFO	-	2.1.1.74	ko:K04094	-	-	-	-	ko00000,ko01000,ko03016,ko03036	-	-	-	GIDA
SHD2_k127_1131556_125	1126627.BAWE01000002_gene553	1.505e-11	67.0	2BUZT@1|root,32QCC@2|Bacteria,1Q8TE@1224|Proteobacteria,2UYDE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_1131556_98	649638.Trad_1402	1.993e-44	165.0	COG1848@1|root,COG1848@2|Bacteria	2|Bacteria	G	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	ko:K07064	-	-	-	-	ko00000	-	-	-	PIN
SHD2_k127_1131556_128	394221.Mmar10_2052	4.479e-07	58.0	COG3832@1|root,COG3832@2|Bacteria,1RH1W@1224|Proteobacteria,2UAVS@28211|Alphaproteobacteria,43YCK@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
SHD2_k127_1131556_117	292459.STH2149	1.357e-20	96.0	COG0640@1|root,COG0640@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	MA20_09440	-	-	-	-	-	-	-	-	-	-	-	HTH_20
SHD2_k127_1131556_18	1333998.M2A_0478	9.698e-170	545.0	COG0154@1|root,COG0154@2|Bacteria,1MWWQ@1224|Proteobacteria,2TSN9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Belongs to the amidase family	MA20_04710	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
SHD2_k127_1131556_27	1174684.EBMC1_07035	1.916e-149	486.0	COG0154@1|root,COG0154@2|Bacteria,1MWWQ@1224|Proteobacteria,2TSN9@28211|Alphaproteobacteria,2K183@204457|Sphingomonadales	204457|Sphingomonadales	J	Belongs to the amidase family	-	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
SHD2_k127_1131556_22	1174684.EBMC1_07035	4.554e-156	505.0	COG0154@1|root,COG0154@2|Bacteria,1MWWQ@1224|Proteobacteria,2TSN9@28211|Alphaproteobacteria,2K183@204457|Sphingomonadales	204457|Sphingomonadales	J	Belongs to the amidase family	-	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
SHD2_k127_1131556_133	888056.HMPREF9062_2272	6.274e-05	54.0	COG4223@1|root,COG4223@2|Bacteria,2I390@201174|Actinobacteria,4D37T@85005|Actinomycetales	201174|Actinobacteria	DZ	transferase activity, transferring acyl groups other than amino-acyl groups	-	-	-	-	-	-	-	-	-	-	-	-	GPDPase_memb
SHD2_k127_1131556_132	1282360.ABAC460_05145	5.278e-05	55.0	2EQCU@1|root,33HYW@2|Bacteria,1NNJJ@1224|Proteobacteria,2UMTZ@28211|Alphaproteobacteria,2KJRK@204458|Caulobacterales	204458|Caulobacterales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_1131556_91	390989.JOEG01000001_gene5143	1.566e-47	181.0	COG1708@1|root,COG1708@2|Bacteria,2IKS6@201174|Actinobacteria,4DGDS@85008|Micromonosporales	201174|Actinobacteria	S	nucleotidyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2
SHD2_k127_1131556_0	1282876.BAOK01000001_gene2054	0.0	1535.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2TQK9@28211|Alphaproteobacteria,4BP8W@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
SHD2_k127_1131556_30	1041147.AUFB01000001_gene4206	7.928e-145	482.0	COG1835@1|root,COG1835@2|Bacteria,1MV2W@1224|Proteobacteria,2TRT8@28211|Alphaproteobacteria,4B7WN@82115|Rhizobiaceae	28211|Alphaproteobacteria	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
SHD2_k127_1131556_81	1336243.JAEA01000005_gene1567	1.695e-62	218.0	COG0629@1|root,COG0629@2|Bacteria,1RCWT@1224|Proteobacteria,2U5BZ@28211|Alphaproteobacteria,1JSVW@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism	ssb	GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
SHD2_k127_1131556_134	1526927.Plano_2234	0.0001602	53.0	COG0265@1|root,COG0265@2|Bacteria,1TSFC@1239|Firmicutes,4HCNP@91061|Bacilli,26ENN@186818|Planococcaceae	91061|Bacilli	O	Trypsin	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin_2,zinc_ribbon_2
SHD2_k127_1131556_114	883080.HMPREF9697_00670	3.942e-26	109.0	COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,2TSPQ@28211|Alphaproteobacteria,3JSSS@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
SHD2_k127_1143198_12	876269.ARWA01000001_gene3143	1.149e-109	362.0	COG0451@1|root,COG0451@2|Bacteria,1MWYB@1224|Proteobacteria,2TSDE@28211|Alphaproteobacteria,3NA80@45404|Beijerinckiaceae	28211|Alphaproteobacteria	GM	PFAM NAD-dependent epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
SHD2_k127_1143198_7	1282876.BAOK01000001_gene1765	1.61e-157	505.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TQQ7@28211|Alphaproteobacteria,4BPQQ@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	I	Thiolase, C-terminal domain	atoB	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
SHD2_k127_1143198_3	438753.AZC_2833	4.17e-208	651.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TREJ@28211|Alphaproteobacteria,3F0S9@335928|Xanthobacteraceae	28211|Alphaproteobacteria	C	Acyl-CoA dehydrogenase, middle domain	ivd2	-	1.3.8.4	ko:K00253	ko00280,ko01100,map00280,map01100	M00036	R04095	RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
SHD2_k127_1143198_42	1040982.AXAL01000015_gene2496	1.678e-24	107.0	COG2827@1|root,COG2827@2|Bacteria	2|Bacteria	L	Endonuclease containing a URI domain	yazA	-	-	ko:K07461	-	-	-	-	ko00000	-	-	-	GIY-YIG
SHD2_k127_1143198_16	1333998.M2A_2890	3.925e-87	297.0	COG0175@1|root,COG0175@2|Bacteria,1MXUR@1224|Proteobacteria,2U5AP@28211|Alphaproteobacteria,4BRQW@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	EH	Reduction of activated sulfate into sulfite	cysH	-	1.8.4.10,1.8.4.8	ko:K00390	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R02021	RC00007,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	PAPS_reduct
SHD2_k127_1143198_36	402881.Plav_2776	1.44e-36	144.0	COG1648@1|root,COG1648@2|Bacteria,1N5PF@1224|Proteobacteria,2UAHG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Sirohaem biosynthesis protein central	-	-	1.3.1.76,4.99.1.4	ko:K02304	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03947	RC01012,RC01034	ko00000,ko00001,ko00002,ko01000	-	-	-	NAD_binding_7,Sirohm_synth_M
SHD2_k127_1143198_43	1333998.M2A_2892	3.13e-22	99.0	COG1886@1|root,COG1886@2|Bacteria,1N1JC@1224|Proteobacteria,2UC3S@28211|Alphaproteobacteria,4BSVP@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	NU	Type III flagellar switch regulator (C-ring) FliN C-term	QU41_23035	-	-	ko:K02417	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	FliMN_C
SHD2_k127_1143198_14	1131814.JAFO01000001_gene2405	6.251e-95	317.0	COG0321@1|root,COG0321@2|Bacteria,1MU6A@1224|Proteobacteria,2TRXJ@28211|Alphaproteobacteria,3EYKV@335928|Xanthobacteraceae	28211|Alphaproteobacteria	H	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate	lipB	GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564	2.3.1.181	ko:K03801	ko00785,ko01100,map00785,map01100	-	R07766,R07769	RC00039,RC00992,RC02867	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
SHD2_k127_1143198_46	1054213.HMPREF9946_00422	6.541e-20	92.0	COG1254@1|root,COG1254@2|Bacteria,1PU46@1224|Proteobacteria,2UF7Z@28211|Alphaproteobacteria,2JTTR@204441|Rhodospirillales	204441|Rhodospirillales	C	Belongs to the acylphosphatase family	acyP	-	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	-	R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000	-	-	-	Acylphosphatase
SHD2_k127_1143198_0	402881.Plav_2772	4.471e-287	895.0	COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,2TRC2@28211|Alphaproteobacteria,1JN43@119043|Rhodobiaceae	28211|Alphaproteobacteria	I	Biotin carboxylase C-terminal domain	pccA	-	6.4.1.3	ko:K01965	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
SHD2_k127_1143198_6	1280954.HPO_18330	2.206e-175	569.0	COG2234@1|root,COG2234@2|Bacteria,1MV86@1224|Proteobacteria,2TVJ5@28211|Alphaproteobacteria,43WXS@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	M28 family peptidase	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
SHD2_k127_1143198_34	59538.XP_005972888.1	2.38e-42	159.0	COG0251@1|root,KOG2317@2759|Eukaryota	2759|Eukaryota	J	endoribonuclease L-PSP	-	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
SHD2_k127_1143198_1	864069.MicloDRAFT_00048710	1.776e-265	824.0	COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2TRI1@28211|Alphaproteobacteria,1JTI4@119045|Methylobacteriaceae	28211|Alphaproteobacteria	I	PFAM carboxyl transferase	pccB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016421,GO:0016874,GO:0016885,GO:0019752,GO:0031974,GO:0032787,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046395,GO:0070013,GO:0071704,GO:0072329,GO:1901575	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
SHD2_k127_1143198_29	331869.BAL199_29580	3.53e-49	192.0	COG5387@1|root,COG5387@2|Bacteria,1Q3B5@1224|Proteobacteria,2TVK1@28211|Alphaproteobacteria,4BQD2@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	O	Chaperone required for the assembly of	-	-	-	-	-	-	-	-	-	-	-	-	ATP12
SHD2_k127_1143198_32	1353529.M899_2883	3.822e-46	181.0	COG3837@1|root,COG3837@2|Bacteria,1R9WZ@1224|Proteobacteria,432KZ@68525|delta/epsilon subdivisions,2WYH1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
SHD2_k127_1143198_13	402881.Plav_2767	4.205e-105	354.0	COG0564@1|root,COG0564@2|Bacteria,1MVDX@1224|Proteobacteria,2TTQC@28211|Alphaproteobacteria,1JN6I@119043|Rhodobiaceae	28211|Alphaproteobacteria	J	RNA pseudouridylate synthase	rluC	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.24	ko:K06179	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
SHD2_k127_1143198_38	1122137.AQXF01000006_gene940	2.815e-33	132.0	COG0239@1|root,COG0239@2|Bacteria,1MZNH@1224|Proteobacteria,2UBUP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	D	Important for reducing fluoride concentration in the cell, thus reducing its toxicity	crcB	-	-	ko:K06199	-	-	-	-	ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3	-	-	CRCB
SHD2_k127_1143198_2	402881.Plav_2765	2.231e-213	669.0	COG2256@1|root,COG2256@2|Bacteria,1MUVS@1224|Proteobacteria,2TQVF@28211|Alphaproteobacteria,1JNND@119043|Rhodobiaceae	28211|Alphaproteobacteria	L	MgsA AAA+ ATPase C terminal	rarA	GO:0005575,GO:0005622,GO:0005623,GO:0005657,GO:0005694,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0030894,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901576	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
SHD2_k127_1143198_8	1333998.M2A_2903	8.609e-148	481.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2TS6B@28211|Alphaproteobacteria,4BPB3@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	O	Trypsin	htrA2	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006457,GO:0006508,GO:0006515,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009897,GO:0009986,GO:0009987,GO:0016020,GO:0016021,GO:0016787,GO:0017171,GO:0019538,GO:0030163,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031233,GO:0031975,GO:0042597,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051603,GO:0061077,GO:0070011,GO:0071575,GO:0071704,GO:0071944,GO:0098552,GO:0140096,GO:1901564,GO:1901565,GO:1901575	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
SHD2_k127_1143198_26	1535287.JP74_01540	2.73e-59	208.0	COG0203@1|root,COG0203@2|Bacteria,1RCWN@1224|Proteobacteria,2U749@28211|Alphaproteobacteria,3N6TQ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Ribosomal protein L17	rplQ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02879	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L17
SHD2_k127_1143198_5	402881.Plav_2760	1.999e-181	572.0	COG0202@1|root,COG0202@2|Bacteria,1MU75@1224|Proteobacteria,2TSI0@28211|Alphaproteobacteria,1JNKV@119043|Rhodobiaceae	28211|Alphaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
SHD2_k127_1143198_25	1122218.KB893653_gene523	9.555e-60	209.0	COG0100@1|root,COG0100@2|Bacteria,1RD0A@1224|Proteobacteria,2U717@28211|Alphaproteobacteria,1JUI5@119045|Methylobacteriaceae	28211|Alphaproteobacteria	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome	rpsK	GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
SHD2_k127_1143198_23	551789.ATVJ01000002_gene3201	2.995e-61	213.0	COG0099@1|root,COG0099@2|Bacteria,1RD1G@1224|Proteobacteria,2U73D@28211|Alphaproteobacteria,43XSJ@69657|Hyphomonadaceae	28211|Alphaproteobacteria	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
SHD2_k127_1143198_9	745310.G432_03895	5.744e-135	448.0	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,2TR1E@28211|Alphaproteobacteria,2K1DJ@204457|Sphingomonadales	204457|Sphingomonadales	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
SHD2_k127_1143198_44	627192.SLG_13640	3.913e-22	108.0	COG1680@1|root,COG1680@2|Bacteria,1MVPR@1224|Proteobacteria,2U5VQ@28211|Alphaproteobacteria,2KD3T@204457|Sphingomonadales	204457|Sphingomonadales	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,DUF3471
SHD2_k127_1143198_22	1333998.M2A_2908	1.645e-62	220.0	COG0563@1|root,COG0563@2|Bacteria,1MXCZ@1224|Proteobacteria,2TT6A@28211|Alphaproteobacteria,4BQBQ@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK,ADK_lid
SHD2_k127_1143198_4	402881.Plav_2756	4.576e-197	623.0	COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,2TQMT@28211|Alphaproteobacteria,1JN33@119043|Rhodobiaceae	28211|Alphaproteobacteria	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
SHD2_k127_1143198_28	272630.MexAM1_META1p2173	1.129e-50	185.0	COG0200@1|root,COG0200@2|Bacteria,1RDC8@1224|Proteobacteria,2U79D@28211|Alphaproteobacteria,1JUHP@119045|Methylobacteriaceae	28211|Alphaproteobacteria	J	Binds to the 23S rRNA	rplO	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
SHD2_k127_1143198_45	1122218.KB893653_gene518	5.648e-20	90.0	COG1841@1|root,COG1841@2|Bacteria,1PU2S@1224|Proteobacteria,2UF55@28211|Alphaproteobacteria,1JW9V@119045|Methylobacteriaceae	28211|Alphaproteobacteria	J	ribosomal protein L30	rpmD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
SHD2_k127_1143198_17	402881.Plav_2753	2.099e-85	286.0	COG0098@1|root,COG0098@2|Bacteria,1MUS4@1224|Proteobacteria,2TSRI@28211|Alphaproteobacteria,1JN3H@119043|Rhodobiaceae	28211|Alphaproteobacteria	J	Belongs to the universal ribosomal protein uS5 family	rpsE	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
SHD2_k127_1143198_39	1122137.AQXF01000006_gene960	4.31e-33	139.0	COG0256@1|root,COG0256@2|Bacteria,1RGY7@1224|Proteobacteria,2U9A6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rplR	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008097,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18p
SHD2_k127_1143198_19	402881.Plav_2751	2.34e-72	248.0	COG0097@1|root,COG0097@2|Bacteria,1R9YZ@1224|Proteobacteria,2TV09@28211|Alphaproteobacteria,1JNVG@119043|Rhodobiaceae	28211|Alphaproteobacteria	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rplF	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
SHD2_k127_1143198_30	1247963.JPHU01000003_gene1249	6.926e-49	182.0	COG0096@1|root,COG0096@2|Bacteria,1RDG3@1224|Proteobacteria,2U6ZH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rpsH	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
SHD2_k127_1143198_37	1380391.JIAS01000006_gene2557	1.945e-36	142.0	COG0199@1|root,COG0199@2|Bacteria,1MZDT@1224|Proteobacteria,2UC01@28211|Alphaproteobacteria,2JT99@204441|Rhodospirillales	204441|Rhodospirillales	J	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site	rpsN	-	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
SHD2_k127_1143198_18	402881.Plav_2748	1.367e-74	257.0	COG0094@1|root,COG0094@2|Bacteria,1MUU9@1224|Proteobacteria,2TQPF@28211|Alphaproteobacteria,1JNPJ@119043|Rhodobiaceae	28211|Alphaproteobacteria	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rplE	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
SHD2_k127_1143198_35	1411123.JQNH01000001_gene1688	2.12e-41	161.0	COG0198@1|root,COG0198@2|Bacteria,1MZQD@1224|Proteobacteria,2UC6Y@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit	rplX	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,ribosomal_L24
SHD2_k127_1143198_24	1267005.KB911261_gene2231	1.267e-60	210.0	COG0093@1|root,COG0093@2|Bacteria,1RCWZ@1224|Proteobacteria,2U743@28211|Alphaproteobacteria,3N6TX@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rplN	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0097159,GO:1901363,GO:1990904	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
SHD2_k127_1143198_40	1248916.ANFY01000003_gene877	9.575e-29	116.0	COG0186@1|root,COG0186@2|Bacteria,1MZIK@1224|Proteobacteria,2UBRF@28211|Alphaproteobacteria,2K5VH@204457|Sphingomonadales	204457|Sphingomonadales	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rpsQ	-	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
SHD2_k127_1143198_48	1280952.HJA_11495	7.223e-15	80.0	COG0255@1|root,COG0255@2|Bacteria,1N6PR@1224|Proteobacteria,2UF59@28211|Alphaproteobacteria,43YI6@69657|Hyphomonadaceae	28211|Alphaproteobacteria	J	Belongs to the universal ribosomal protein uL29 family	rpmC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
SHD2_k127_1143198_21	631454.N177_0738	1.45e-66	231.0	COG0197@1|root,COG0197@2|Bacteria,1RA0Z@1224|Proteobacteria,2U710@28211|Alphaproteobacteria,1JNU1@119043|Rhodobiaceae	28211|Alphaproteobacteria	J	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs	rplP	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904	-	ko:K02878	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
SHD2_k127_1143198_11	319003.Bra1253DRAFT_07952	6.213e-117	381.0	COG0092@1|root,COG0092@2|Bacteria,1MUAI@1224|Proteobacteria,2TRZ2@28211|Alphaproteobacteria,3JVAT@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
SHD2_k127_1143198_33	1123229.AUBC01000027_gene3983	2.273e-43	165.0	COG0091@1|root,COG0091@2|Bacteria,1RH0W@1224|Proteobacteria,2U96X@28211|Alphaproteobacteria,3JY53@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rplV	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
SHD2_k127_1143198_31	1411123.JQNH01000001_gene1695	1.289e-46	168.0	COG0185@1|root,COG0185@2|Bacteria,1RGYX@1224|Proteobacteria,2U95S@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rpsS	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
SHD2_k127_1143198_10	1437448.AZRT01000019_gene1201	1.741e-133	429.0	COG0090@1|root,COG0090@2|Bacteria,1MVTD@1224|Proteobacteria,2TTKD@28211|Alphaproteobacteria,1J1PV@118882|Brucellaceae	28211|Alphaproteobacteria	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
SHD2_k127_1143198_41	1144307.PMI04_01302	2.069e-28	119.0	COG0089@1|root,COG0089@2|Bacteria,1MZXX@1224|Proteobacteria,2UBQ1@28211|Alphaproteobacteria,2K54N@204457|Sphingomonadales	204457|Sphingomonadales	J	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome	rplW	-	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
SHD2_k127_1143198_20	1211115.ALIQ01000213_gene2549	3.268e-70	243.0	COG0088@1|root,COG0088@2|Bacteria,1MXPF@1224|Proteobacteria,2TRUT@28211|Alphaproteobacteria,3N9WU@45404|Beijerinckiaceae	28211|Alphaproteobacteria	J	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome	rplD	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02926	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
SHD2_k127_1143198_15	414684.RC1_0711	6.455e-93	318.0	COG0087@1|root,COG0087@2|Bacteria,1MUST@1224|Proteobacteria,2TRHB@28211|Alphaproteobacteria,2JPA8@204441|Rhodospirillales	204441|Rhodospirillales	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
SHD2_k127_1143198_27	666684.AfiDRAFT_3578	1.682e-55	195.0	COG0051@1|root,COG0051@2|Bacteria,1RGWF@1224|Proteobacteria,2U95D@28211|Alphaproteobacteria,3JYY3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	J	Involved in the binding of tRNA to the ribosomes	rpsJ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
SHD2_k127_1143198_47	648757.Rvan_2978	5.023e-18	83.0	COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,2TQP8@28211|Alphaproteobacteria,3N6BR@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
SHD2_k127_1279120_1	113395.AXAI01000024_gene3766	1.178e-62	223.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
SHD2_k127_1279120_0	1150626.PHAMO_430006	7.403e-167	531.0	COG3335@1|root,COG3335@2|Bacteria,1MW7X@1224|Proteobacteria,2TTH8@28211|Alphaproteobacteria,2JV2N@204441|Rhodospirillales	204441|Rhodospirillales	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_32
SHD2_k127_1279120_2	388739.RSK20926_12914	4.63e-23	100.0	COG1237@1|root,COG1237@2|Bacteria,1NK2I@1224|Proteobacteria,2TTSG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	beta-lactamase	-	-	2.5.1.105	ko:K06897	ko00790,map00790	-	R10339	RC00121	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
SHD2_k127_1281323_0	1206737.BAGF01000026_gene1359	8.905e-58	215.0	COG1414@1|root,COG1414@2|Bacteria,2I3CC@201174|Actinobacteria,4FWJM@85025|Nocardiaceae	201174|Actinobacteria	K	O-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Dimerisation2,Methyltransf_2
SHD2_k127_1281323_1	5833.PF10_0306	5.907e-23	106.0	COG5253@1|root,KOG0229@2759|Eukaryota,3Y9Y8@5794|Apicomplexa,3KBW5@422676|Aconoidasida,3YXVA@5819|Haemosporida	422676|Aconoidasida	T	Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases.	-	-	-	-	-	-	-	-	-	-	-	-	MORN
SHD2_k127_1405936_14	1114970.PSF113_3064	8.305e-58	212.0	COG0583@1|root,COG0583@2|Bacteria,1MWY0@1224|Proteobacteria,1RP7Q@1236|Gammaproteobacteria,1YTCK@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	K	Bacterial regulatory helix-turn-helix protein, lysR family	ampR	-	-	ko:K03566,ko:K17850	ko01501,ko02026,map01501,map02026	M00628	-	-	ko00000,ko00001,ko00002,ko03000	-	-	-	HTH_1,LysR_substrate
SHD2_k127_1405936_13	1502850.FG91_02806	5.283e-75	257.0	COG0346@1|root,COG0346@2|Bacteria,1MWCV@1224|Proteobacteria,2U6HU@28211|Alphaproteobacteria,2KANC@204457|Sphingomonadales	204457|Sphingomonadales	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
SHD2_k127_1405936_18	1280954.HPO_17993	1.52e-44	164.0	COG3631@1|root,COG3631@2|Bacteria,1NF7U@1224|Proteobacteria,2UH89@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
SHD2_k127_1405936_3	1211115.ALIQ01000200_gene483	1.245e-192	614.0	COG0477@1|root,COG2814@2|Bacteria,1MU1I@1224|Proteobacteria,2TVXT@28211|Alphaproteobacteria,3ND1F@45404|Beijerinckiaceae	28211|Alphaproteobacteria	P	Sugar (and other) transporter	-	-	-	ko:K03446	-	M00701	-	-	ko00000,ko00002,ko02000	2.A.1.3	-	-	MFS_1,Sugar_tr
SHD2_k127_1405936_1	1333998.M2A_0166	1.034e-227	728.0	COG2010@1|root,COG4993@1|root,COG2010@2|Bacteria,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2TS2Q@28211|Alphaproteobacteria,4BTBE@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	CG	PQQ enzyme repeat	-	-	1.1.9.1	ko:K17760	-	-	-	-	ko00000,ko01000	-	-	-	Cytochrome_CBB3,PQQ,PQQ_2
SHD2_k127_1405936_10	69395.JQLZ01000001_gene3321	1.064e-95	326.0	28NB7@1|root,2ZBEQ@2|Bacteria,1R97X@1224|Proteobacteria,2U16I@28211|Alphaproteobacteria,2KJXZ@204458|Caulobacterales	204458|Caulobacterales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_1405936_22	1282876.BAOK01000001_gene1620	2.242e-24	110.0	28I3D@1|root,2Z876@2|Bacteria,1P0DR@1224|Proteobacteria,2TTG2@28211|Alphaproteobacteria,4BSQS@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	PilZ domain	MA20_31715	-	-	-	-	-	-	-	-	-	-	-	PilZ
SHD2_k127_1405936_25	509190.Cseg_4161	1.571e-05	57.0	COG1522@1|root,COG1522@2|Bacteria,1NUG8@1224|Proteobacteria,2URHY@28211|Alphaproteobacteria,2KIMD@204458|Caulobacterales	204458|Caulobacterales	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_1405936_15	1121106.JQKB01000106_gene6026	7.285e-52	197.0	COG3734@1|root,COG3734@2|Bacteria,1MWGX@1224|Proteobacteria,2TTG8@28211|Alphaproteobacteria,2JSCZ@204441|Rhodospirillales	204441|Rhodospirillales	G	2-keto-3-deoxy-galactonokinase	dgoK	-	2.7.1.58	ko:K00883	ko00052,ko01100,map00052,map01100	M00552	R03387	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	DGOK
SHD2_k127_1405936_7	1207063.P24_08619	4.265e-112	371.0	COG1176@1|root,COG1176@2|Bacteria,1MVGM@1224|Proteobacteria,2TSFD@28211|Alphaproteobacteria,2JQTE@204441|Rhodospirillales	204441|Rhodospirillales	E	Putrescine transport system permease	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
SHD2_k127_1405936_11	1207063.P24_08614	2.44e-93	321.0	COG1177@1|root,COG1177@2|Bacteria,1MVC5@1224|Proteobacteria,2TRRJ@28211|Alphaproteobacteria,2JS0G@204441|Rhodospirillales	204441|Rhodospirillales	E	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
SHD2_k127_1405936_6	1207063.P24_08609	4.998e-124	409.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQMJ@28211|Alphaproteobacteria,2JPVQ@204441|Rhodospirillales	204441|Rhodospirillales	E	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,TOBE_2
SHD2_k127_1405936_0	402881.Plav_0946	3.731e-293	928.0	COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,2TRY7@28211|Alphaproteobacteria,1JMZX@119043|Rhodobiaceae	28211|Alphaproteobacteria	OT	Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell	glnE	GO:0000820,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006521,GO:0008150,GO:0008882,GO:0010565,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0031323,GO:0033238,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0062012,GO:0065007,GO:0070566,GO:0080090	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
SHD2_k127_1405936_4	1333998.M2A_1672	1.962e-129	427.0	COG0642@1|root,COG2770@1|root,COG2205@2|Bacteria,COG2770@2|Bacteria,1MW8M@1224|Proteobacteria,2TUSJ@28211|Alphaproteobacteria,4BPUS@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	T	His Kinase A (phosphoacceptor) domain	ragB	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
SHD2_k127_1405936_8	1282876.BAOK01000001_gene2555	2.558e-107	351.0	COG0745@1|root,COG0745@2|Bacteria,1MU67@1224|Proteobacteria,2TRTZ@28211|Alphaproteobacteria,4BPTM@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	KT	Transcriptional regulatory protein, C terminal	ragA	GO:0000160,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005515,GO:0006355,GO:0007154,GO:0007165,GO:0008150,GO:0009889,GO:0009893,GO:0009987,GO:0010035,GO:0010038,GO:0010468,GO:0010556,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0023052,GO:0031323,GO:0031326,GO:0035556,GO:0042221,GO:0042802,GO:0046688,GO:0048518,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
SHD2_k127_1405936_5	1333998.M2A_1336	8.427e-126	421.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2TQPZ@28211|Alphaproteobacteria,4BPCV@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	O	Belongs to the peptidase S1C family	degP	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ,PDZ_2,Trypsin_2
SHD2_k127_1405936_20	1040989.AWZU01000054_gene3493	1.488e-34	139.0	COG3088@1|root,COG3088@2|Bacteria,1MZZ5@1224|Proteobacteria,2U96P@28211|Alphaproteobacteria,3JYWC@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	subunit of a heme lyase	cycL	-	-	ko:K02200	-	-	-	-	ko00000	-	-	-	CcmH
SHD2_k127_1405936_2	402881.Plav_0941	1.099e-202	653.0	COG1138@1|root,COG1138@2|Bacteria,1MUQS@1224|Proteobacteria,2TRNG@28211|Alphaproteobacteria,1JNIB@119043|Rhodobiaceae	28211|Alphaproteobacteria	O	Cytochrome c-type biogenesis protein CcmF C-terminal	ccmF	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
SHD2_k127_1405936_19	1038860.AXAP01000079_gene1500	2.148e-42	160.0	COG2332@1|root,COG2332@2|Bacteria,1RHN5@1224|Proteobacteria,2U99J@28211|Alphaproteobacteria,3JYFM@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH	ccmE	GO:0003674,GO:0003824,GO:0008150,GO:0009987,GO:0016043,GO:0017004,GO:0022607,GO:0034622,GO:0043933,GO:0044085,GO:0065003,GO:0071840	-	ko:K02197	-	-	-	-	ko00000	-	-	-	CcmE
SHD2_k127_1405936_16	930166.CD58_16700	2.458e-49	181.0	COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,1S8NE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
SHD2_k127_1405936_17	190650.CC_0223	2.525e-47	180.0	COG0596@1|root,COG0596@2|Bacteria,1N252@1224|Proteobacteria,2UHSE@28211|Alphaproteobacteria,2KIRM@204458|Caulobacterales	204458|Caulobacterales	S	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
SHD2_k127_1405936_21	1449049.JONW01000005_gene1965	6.572e-27	117.0	COG3784@1|root,COG3784@2|Bacteria,1Q455@1224|Proteobacteria,2UIVQ@28211|Alphaproteobacteria,2KHB5@204458|Caulobacterales	204458|Caulobacterales	S	Protein of unknown function (DUF1318)	-	-	-	ko:K09978	-	-	-	-	ko00000	-	-	-	DUF1318
SHD2_k127_1405936_23	509190.Cseg_0134	5.968e-18	85.0	2FB83@1|root,343EB@2|Bacteria,1NGPR@1224|Proteobacteria,2UMZV@28211|Alphaproteobacteria,2KJPK@204458|Caulobacterales	204458|Caulobacterales	S	YnbE-like lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	Lipoprotein_19
SHD2_k127_1405936_9	1292034.OR37_01615	1.116e-99	359.0	COG2911@1|root,COG2911@2|Bacteria,1R6VP@1224|Proteobacteria,2U46Q@28211|Alphaproteobacteria,2KFU1@204458|Caulobacterales	204458|Caulobacterales	S	Dicarboxylate transport	-	-	-	-	-	-	-	-	-	-	-	-	DctA-YdbH
SHD2_k127_1405936_24	394221.Mmar10_0416	2.485e-12	68.0	COG3847@1|root,COG3847@2|Bacteria,1NGVU@1224|Proteobacteria,2UJE8@28211|Alphaproteobacteria,43YY0@69657|Hyphomonadaceae	28211|Alphaproteobacteria	U	Flp/Fap pilin component	-	-	-	ko:K02651	ko04112,map04112	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	Flp_Fap
SHD2_k127_1405936_12	1242864.D187_003622	2.154e-76	267.0	COG3570@1|root,COG3570@2|Bacteria	2|Bacteria	V	aminoglycoside hydroxyurea antibiotic resistance kinase	-	-	2.7.1.72	ko:K04343	-	M00766	R02225	RC00002,RC00078	br01600,ko00000,ko00002,ko01000,ko01504	-	-	-	APH_6_hur
SHD2_k127_1427855_3	450851.PHZ_c3143	7.055e-87	294.0	COG1073@1|root,COG1073@2|Bacteria,1QY19@1224|Proteobacteria,2TXFD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	PFAM alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
SHD2_k127_1427855_5	1408419.JHYG01000001_gene1994	8.048e-67	231.0	COG0229@1|root,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,2U70T@28211|Alphaproteobacteria,2JTFN@204441|Rhodospirillales	204441|Rhodospirillales	O	SelR domain	msrB	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
SHD2_k127_1427855_2	402881.Plav_0283	1.13e-115	379.0	COG2513@1|root,COG2513@2|Bacteria,1N4VT@1224|Proteobacteria,2TTP8@28211|Alphaproteobacteria,1JQ2Q@119043|Rhodobiaceae	28211|Alphaproteobacteria	G	Phosphoenolpyruvate phosphomutase	-	-	4.1.3.32	ko:K20454	ko00760,ko01120,map00760,map01120	-	R01355	RC00286,RC01810	ko00000,ko00001,ko01000	-	-	-	PEP_mutase
SHD2_k127_1427855_0	402881.Plav_0817	5.677e-270	848.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2TQMR@28211|Alphaproteobacteria,1JNCY@119043|Rhodobiaceae	28211|Alphaproteobacteria	V	ABC transporter transmembrane region	-	-	-	ko:K06147,ko:K18890	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
SHD2_k127_1427855_1	402881.Plav_0818	1.122e-232	737.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2U3UT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	ABC transporter, transmembrane region	-	-	-	ko:K06147,ko:K18889	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
SHD2_k127_1427855_4	1161401.ASJA01000005_gene2507	7.687e-86	301.0	COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,2TSXA@28211|Alphaproteobacteria,43W9W@69657|Hyphomonadaceae	28211|Alphaproteobacteria	OU	signal peptide peptidase	sppA	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
SHD2_k127_1624914_1	1411123.JQNH01000001_gene3285	8.593e-86	287.0	COG0825@1|root,COG0825@2|Bacteria,1MURN@1224|Proteobacteria,2TR6V@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA	accA	-	2.1.3.15,6.4.1.2	ko:K01962	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	ACCA
SHD2_k127_1624914_0	335283.Neut_1746	2.525e-156	498.0	COG2801@1|root,COG2801@2|Bacteria,1MVQ9@1224|Proteobacteria,2VMCX@28216|Betaproteobacteria,372AC@32003|Nitrosomonadales	28216|Betaproteobacteria	L	PFAM Integrase, catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	rve,rve_3
SHD2_k127_1809722_10	1219035.NT2_07_00370	2.448e-87	318.0	COG1629@1|root,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,2TT5V@28211|Alphaproteobacteria,2K2HZ@204457|Sphingomonadales	204457|Sphingomonadales	P	TonB dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
SHD2_k127_1809722_12	1280946.HY29_13415	5.021e-62	219.0	COG0346@1|root,COG0346@2|Bacteria,1MWCV@1224|Proteobacteria,2U6HU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
SHD2_k127_1809722_8	1149133.ppKF707_0108	5.1e-99	340.0	COG2271@1|root,COG2271@2|Bacteria,1MWYR@1224|Proteobacteria,1RR7T@1236|Gammaproteobacteria,1YD63@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SHD2_k127_1809722_2	450851.PHZ_c2131	8.329e-179	583.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TR7Q@28211|Alphaproteobacteria,2KFBR@204458|Caulobacterales	204458|Caulobacterales	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
SHD2_k127_1809722_6	1174684.EBMC1_02830	3.057e-101	340.0	COG0119@1|root,COG0119@2|Bacteria,1MUMX@1224|Proteobacteria,2TT1R@28211|Alphaproteobacteria,2K1YI@204457|Sphingomonadales	204457|Sphingomonadales	E	HMGL-like	-	-	4.1.3.4	ko:K01640	ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146	M00036,M00088	R01360,R08090	RC00502,RC00503,RC01118,RC01946	ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
SHD2_k127_1809722_3	1537715.JQFJ01000005_gene38	8.003e-169	540.0	COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,2TR04@28211|Alphaproteobacteria,2K00W@204457|Sphingomonadales	204457|Sphingomonadales	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno_2	-	-	-	-	-	-	-	-	-	-	-	Enolase_C,Enolase_N
SHD2_k127_1809722_5	1429916.X566_16830	5.212e-104	356.0	COG1052@1|root,COG1052@2|Bacteria,1MU2D@1224|Proteobacteria,2TQPQ@28211|Alphaproteobacteria,3JRXB@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	CH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	hprA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	1.1.1.29	ko:K00018	ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200	M00346	R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko00002,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
SHD2_k127_1809722_11	1502850.FG91_02803	1.326e-66	234.0	COG2267@1|root,COG2267@2|Bacteria,1QUZX@1224|Proteobacteria,2TWE4@28211|Alphaproteobacteria,2K4WA@204457|Sphingomonadales	204457|Sphingomonadales	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
SHD2_k127_1809722_4	1502850.FG91_02804	7.27e-150	485.0	COG0620@1|root,COG0620@2|Bacteria,1MUI9@1224|Proteobacteria,2TTWK@28211|Alphaproteobacteria,2K3CA@204457|Sphingomonadales	204457|Sphingomonadales	E	Cobalamin-independent synthase, Catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Meth_synt_2
SHD2_k127_1809722_14	317655.Sala_1858	3.916e-44	168.0	COG1846@1|root,COG1846@2|Bacteria,1REBI@1224|Proteobacteria	1224|Proteobacteria	K	Regulatory protein MarR	-	-	-	-	-	-	-	-	-	-	-	-	MarR
SHD2_k127_1809722_1	1502850.FG91_02799	4.067e-190	599.0	COG1073@1|root,COG1073@2|Bacteria,1NX52@1224|Proteobacteria,2TSJM@28211|Alphaproteobacteria,2K13I@204457|Sphingomonadales	204457|Sphingomonadales	I	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_1809722_0	1174684.EBMC1_14555	5.717e-270	839.0	COG0318@1|root,COG0318@2|Bacteria,1MUMC@1224|Proteobacteria,2TR96@28211|Alphaproteobacteria,2K0TE@204457|Sphingomonadales	204457|Sphingomonadales	IQ	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
SHD2_k127_1809722_15	1280954.HPO_17973	2.878e-41	157.0	COG1846@1|root,COG1846@2|Bacteria,1N7BN@1224|Proteobacteria,2UINK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	MarR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_27,MarR_2
SHD2_k127_1809722_7	450851.PHZ_c2268	6.875e-100	329.0	COG2128@1|root,COG2128@2|Bacteria,1PMH5@1224|Proteobacteria,2TVAY@28211|Alphaproteobacteria,2KF8S@204458|Caulobacterales	204458|Caulobacterales	S	Carboxymuconolactone decarboxylase family	-	-	-	-	-	-	-	-	-	-	-	-	CMD
SHD2_k127_1809722_13	1174684.EBMC1_14595	4.659e-53	195.0	2DMP1@1|root,32SS8@2|Bacteria,1MZTD@1224|Proteobacteria,2U86W@28211|Alphaproteobacteria,2K5F0@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function (DUF3237)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3237
SHD2_k127_1809722_9	1502850.FG91_03392	6.014e-93	316.0	COG0582@1|root,COG0582@2|Bacteria,1MU23@1224|Proteobacteria,2U05W@28211|Alphaproteobacteria,2K2J8@204457|Sphingomonadales	204457|Sphingomonadales	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Arm-DNA-bind_3,Phage_integrase
SHD2_k127_1815668_29	1220535.IMCC14465_13940	3.598e-35	136.0	COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,2TSCJ@28211|Alphaproteobacteria,4BP9I@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
SHD2_k127_1815668_1	991905.SL003B_2026	3.46e-233	736.0	COG4986@1|root,COG4986@2|Bacteria,1MV85@1224|Proteobacteria,2TTRP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
SHD2_k127_1815668_4	991905.SL003B_2024	2.186e-184	585.0	COG1116@1|root,COG4754@1|root,COG1116@2|Bacteria,COG4754@2|Bacteria,1MUDV@1224|Proteobacteria,2TRXZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	ABC transporter	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	AAA_assoc_C,ABC_tran
SHD2_k127_1815668_24	1869.MB27_34115	3.55e-45	175.0	2CCFM@1|root,33T1W@2|Bacteria,2IA4M@201174|Actinobacteria,4DI3H@85008|Micromonosporales	201174|Actinobacteria	S	Phytanoyl-CoA dioxygenase (PhyH)	-	-	-	-	-	-	-	-	-	-	-	-	PhyH
SHD2_k127_1815668_3	402881.Plav_2474	6.722e-186	587.0	COG0027@1|root,COG0027@2|Bacteria,1N3KA@1224|Proteobacteria,2TVIF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	F	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate	purT	-	2.1.2.2	ko:K08289	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp,Epimerase
SHD2_k127_1815668_2	652103.Rpdx1_3477	3.04e-188	592.0	COG0059@1|root,COG0059@2|Bacteria,1MV7M@1224|Proteobacteria,2TRXI@28211|Alphaproteobacteria,3JT4K@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EH	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
SHD2_k127_1815668_18	402881.Plav_2465	3.619e-77	262.0	COG0440@1|root,COG0440@2|Bacteria,1RAGN@1224|Proteobacteria,2U5CW@28211|Alphaproteobacteria,1JNZ6@119043|Rhodobiaceae	28211|Alphaproteobacteria	E	ACT domain	ilvH	-	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,ACT_5,ALS_ss_C
SHD2_k127_1815668_0	402881.Plav_2464	6.077e-295	914.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2TR1I@28211|Alphaproteobacteria,1JNIX@119043|Rhodobiaceae	28211|Alphaproteobacteria	EH	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain	ilvI	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
SHD2_k127_1815668_17	935557.ATYB01000014_gene3165	9.137e-85	291.0	COG0324@1|root,COG0324@2|Bacteria,1MUB2@1224|Proteobacteria,2TR8Z@28211|Alphaproteobacteria,4B7S9@82115|Rhizobiaceae	28211|Alphaproteobacteria	J	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
SHD2_k127_1815668_16	1280952.HJA_01720	5.912e-86	295.0	COG0560@1|root,COG0560@2|Bacteria,1MWA3@1224|Proteobacteria,2TSEU@28211|Alphaproteobacteria,43XBC@69657|Hyphomonadaceae	28211|Alphaproteobacteria	E	haloacid dehalogenase-like hydrolase	serB	-	3.1.3.3	ko:K01079	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R00582	RC00017	ko00000,ko00001,ko00002,ko01000,ko01009	-	-	-	HAD
SHD2_k127_1815668_6	1380394.JADL01000002_gene1388	2.23e-146	489.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2TQPZ@28211|Alphaproteobacteria,2JQVG@204441|Rhodospirillales	204441|Rhodospirillales	O	Belongs to the peptidase S1C family	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
SHD2_k127_1815668_23	266264.Rmet_5084	1.321e-45	169.0	COG0662@1|root,COG0662@2|Bacteria,1N1YZ@1224|Proteobacteria,2VU48@28216|Betaproteobacteria,1K9YZ@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
SHD2_k127_1815668_15	1282876.BAOK01000001_gene1400	1.957e-91	309.0	COG0330@1|root,COG0330@2|Bacteria,1MV7R@1224|Proteobacteria,2TRP4@28211|Alphaproteobacteria,4BPGN@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	O	HflC and HflK could regulate a protease	hflC	-	-	ko:K04087	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
SHD2_k127_1815668_10	438753.AZC_2569	1.846e-115	385.0	COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,2TRTP@28211|Alphaproteobacteria,3EZ43@335928|Xanthobacteraceae	28211|Alphaproteobacteria	O	HflC and HflK could encode or regulate a protease	hflK	-	-	ko:K04088	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7,HflK_N
SHD2_k127_1815668_9	402881.Plav_2457	1.513e-128	425.0	COG0489@1|root,COG0489@2|Bacteria,1MU7R@1224|Proteobacteria,2TRDM@28211|Alphaproteobacteria,1JN8P@119043|Rhodobiaceae	28211|Alphaproteobacteria	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	mrp	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	FeS_assembly_P,ParA
SHD2_k127_1815668_27	1205680.CAKO01000040_gene915	2.141e-39	154.0	COG3751@1|root,COG3751@2|Bacteria,1NAUK@1224|Proteobacteria	1224|Proteobacteria	O	Putative 2OG-Fe(II) oxygenase	-	-	-	-	-	-	-	-	-	-	-	-	2OG-FeII_Oxy_5
SHD2_k127_1815668_12	224911.27351339	2.625e-105	354.0	COG0189@1|root,COG0189@2|Bacteria,1NX9V@1224|Proteobacteria,2TU7A@28211|Alphaproteobacteria,3JSIX@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	HJ	ligase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_1815668_14	113395.AXAI01000032_gene701	4.699e-93	311.0	COG0605@1|root,COG0605@2|Bacteria,1R4Z3@1224|Proteobacteria,2U38P@28211|Alphaproteobacteria,3JT9I@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Iron/manganese superoxide dismutases, C-terminal domain	chrC	-	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C
SHD2_k127_1815668_35	190650.CC_1472	0.0001133	50.0	2C3EC@1|root,33W7V@2|Bacteria,1NVYE@1224|Proteobacteria,2USF2@28211|Alphaproteobacteria,2KJEN@204458|Caulobacterales	204458|Caulobacterales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_1815668_11	69395.JQLZ01000001_gene2836	4.697e-106	357.0	COG3386@1|root,COG3386@2|Bacteria,1MXVD@1224|Proteobacteria,2TVCW@28211|Alphaproteobacteria,2KFUI@204458|Caulobacterales	204458|Caulobacterales	G	SMP-30/Gluconolaconase/LRE-like region	-	-	3.1.1.17	ko:K01053	ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02933,R03751	RC00537,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	SGL
SHD2_k127_1815668_22	113395.AXAI01000031_gene594	1.225e-51	187.0	COG0262@1|root,COG0262@2|Bacteria,1RH0P@1224|Proteobacteria,2U9GC@28211|Alphaproteobacteria,3JQWH@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	H	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis	folA	-	1.5.1.3	ko:K00287	ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523	M00126,M00840	R00936,R00937,R00939,R00940,R02235,R02236,R11765	RC00109,RC00110,RC00158	ko00000,ko00001,ko00002,ko01000	-	-	-	DHFR_1
SHD2_k127_1815668_25	1510531.JQJJ01000008_gene3592	1.413e-41	158.0	COG1247@1|root,COG1247@2|Bacteria,1QU4K@1224|Proteobacteria,2TVZA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
SHD2_k127_1815668_20	1211115.ALIQ01000230_gene1653	1.855e-61	215.0	COG0454@1|root,COG0454@2|Bacteria,1QTZ4@1224|Proteobacteria,2U7E4@28211|Alphaproteobacteria,3NB4I@45404|Beijerinckiaceae	28211|Alphaproteobacteria	K	Acetyltransferase (GNAT) domain	MA20_02285	-	2.3.1.57	ko:K00657	ko00330,ko01100,ko04216,map00330,map01100,map04216	M00135	R01154	RC00004,RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_1
SHD2_k127_1815668_30	983920.Y88_1064	1.298e-19	98.0	COG5455@1|root,COG5455@2|Bacteria	2|Bacteria	D	response to cobalt ion	cigR	-	-	-	-	-	-	-	-	-	-	-	RcnB
SHD2_k127_1815668_8	883078.HMPREF9695_02969	1.328e-140	449.0	COG0207@1|root,COG0207@2|Bacteria,1MUBD@1224|Proteobacteria,2TQSB@28211|Alphaproteobacteria,3JV7Q@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis	thyA	-	2.1.1.45	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylat_synt
SHD2_k127_1815668_31	1132836.RCCGE510_12016	7.658e-08	55.0	2A9UM@1|root,30Z2G@2|Bacteria,1PQIA@1224|Proteobacteria,2V2X8@28211|Alphaproteobacteria,4BJT2@82115|Rhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_1815668_21	69395.JQLZ01000001_gene2671	2.488e-58	205.0	COG5649@1|root,COG5649@2|Bacteria,1Q80H@1224|Proteobacteria,2UV0B@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
SHD2_k127_1815668_19	1449076.JOOE01000003_gene3534	3.718e-63	217.0	COG5507@1|root,COG5507@2|Bacteria,1RHC1@1224|Proteobacteria,2UC7A@28211|Alphaproteobacteria,2KA7B@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function (DUF1428)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1428
SHD2_k127_1815668_7	450851.PHZ_c0896	2.408e-141	465.0	COG0477@1|root,COG2814@2|Bacteria,1QYNP@1224|Proteobacteria,2U1VX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SHD2_k127_1815668_13	1150626.PHAMO_340086	4.25e-96	330.0	COG0477@1|root,COG0477@2|Bacteria,1MXZ3@1224|Proteobacteria,2TSHC@28211|Alphaproteobacteria,2JZ5A@204441|Rhodospirillales	204441|Rhodospirillales	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
SHD2_k127_1815668_5	883078.HMPREF9695_00694	7.271e-148	476.0	COG1902@1|root,COG1902@2|Bacteria,1MVIX@1224|Proteobacteria,2TT2F@28211|Alphaproteobacteria,3JX03@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	NADH:flavin oxidoreductase / NADH oxidase family	-	-	1.14.13.40	ko:K09461	ko00627,ko01120,map00627,map01120	-	R03998,R03999	RC00244	ko00000,ko00001,ko01000	-	-	-	Oxidored_FMN
SHD2_k127_1815668_28	234267.Acid_7797	1.439e-36	147.0	2E8G8@1|root,332UI@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	VPEP
SHD2_k127_1815668_26	266264.Rmet_5664	2.889e-40	156.0	2E9SI@1|root,333YQ@2|Bacteria,1RI7T@1224|Proteobacteria,2VSGB@28216|Betaproteobacteria,1K880@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF3761)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3761
SHD2_k127_1815668_32	1192759.AKIB01000088_gene2291	9.747e-08	57.0	2AY5B@1|root,31Q79@2|Bacteria,1NF1Q@1224|Proteobacteria,2UH21@28211|Alphaproteobacteria,2K86Y@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_189387_9	1207063.P24_07504	9.435e-19	88.0	COG2267@1|root,COG2267@2|Bacteria,1MWDA@1224|Proteobacteria,2TSZ4@28211|Alphaproteobacteria,2JT0F@204441|Rhodospirillales	204441|Rhodospirillales	I	Serine aminopeptidase, S33	pldB	-	3.1.1.5	ko:K01048	ko00564,map00564	-	-	-	ko00000,ko00001,ko01000	-	-	-	Hydrolase_4
SHD2_k127_189387_5	661478.OP10G_2441	1.457e-95	335.0	COG0457@1|root,COG0457@2|Bacteria	661478.OP10G_2441|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_189387_4	1286093.C266_15322	9.349e-105	347.0	COG0596@1|root,COG0596@2|Bacteria,1REZX@1224|Proteobacteria,2VUNN@28216|Betaproteobacteria,1K0ZR@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
SHD2_k127_189387_6	402881.Plav_1982	1.011e-76	266.0	COG0483@1|root,COG0483@2|Bacteria,1PPJ0@1224|Proteobacteria,2TQTX@28211|Alphaproteobacteria,1JNX0@119043|Rhodobiaceae	28211|Alphaproteobacteria	G	Inositol monophosphatase family	hisN	-	3.1.3.15,3.1.3.25,3.1.3.93	ko:K01092,ko:K18649	ko00053,ko00340,ko00521,ko00562,ko01100,ko01110,ko01230,ko04070,map00053,map00340,map00521,map00562,map01100,map01110,map01230,map04070	M00026,M00114,M00131	R01185,R01186,R01187,R03013,R07674	RC00017,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
SHD2_k127_189387_3	69395.JQLZ01000003_gene337	1.066e-117	384.0	COG4221@1|root,COG4221@2|Bacteria,1R83E@1224|Proteobacteria,2TVY6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
SHD2_k127_189387_1	414684.RC1_3946	1.232e-274	857.0	COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,2TR63@28211|Alphaproteobacteria,2JQ9U@204441|Rhodospirillales	204441|Rhodospirillales	T	GTP-binding protein TypA	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
SHD2_k127_189387_8	880072.Desac_1403	8.428e-58	216.0	COG0845@1|root,COG0845@2|Bacteria,1MW65@1224|Proteobacteria,42NJG@68525|delta/epsilon subdivisions,2WJ8R@28221|Deltaproteobacteria,2MR7H@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K07799	ko02020,map02020	M00648	-	-	ko00000,ko00001,ko00002,ko02000	8.A.1	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
SHD2_k127_189387_0	522306.CAP2UW1_0607	0.0	1134.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,1KQDX@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	V	AcrB/AcrD/AcrF family	mdtC	-	-	ko:K03296,ko:K07788,ko:K07789,ko:K21133	ko02020,map02020	M00648,M00822	-	-	ko00000,ko00001,ko00002,ko02000	2.A.6.2,2.A.6.2.35	-	-	ACR_tran
SHD2_k127_189387_2	1380394.JADL01000009_gene3114	3.654e-123	402.0	COG0667@1|root,COG0667@2|Bacteria,1MV2Y@1224|Proteobacteria,2TS02@28211|Alphaproteobacteria,2JVXA@204441|Rhodospirillales	204441|Rhodospirillales	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
SHD2_k127_189387_11	648757.Rvan_2808	0.0001034	49.0	COG1396@1|root,COG1396@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,HTH_31
SHD2_k127_189387_10	169963.lmo2319	4.529e-06	52.0	2E5K5@1|root,330BC@2|Bacteria,1VC9N@1239|Firmicutes,4HM43@91061|Bacilli,26KK1@186820|Listeriaceae	91061|Bacilli	S	Siphovirus Gp157	-	-	-	-	-	-	-	-	-	-	-	-	Sipho_Gp157
SHD2_k127_189387_7	670307.HYPDE_23078	6.457e-68	247.0	COG5055@1|root,COG5055@2|Bacteria,1QWK7@1224|Proteobacteria	1224|Proteobacteria	L	Protein of unknown function (DUF968)	-	-	-	-	-	-	-	-	-	-	-	-	DUF968,ERF,Rad52_Rad22
SHD2_k127_205705_40	393595.ABO_2707	1.191e-12	70.0	COG3239@1|root,COG3239@2|Bacteria,1MW29@1224|Proteobacteria,1RPHS@1236|Gammaproteobacteria,1XN2A@135619|Oceanospirillales	135619|Oceanospirillales	C	Fatty acid desaturase	-	GO:0003674,GO:0003824,GO:0004497,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016491,GO:0016705,GO:0016713,GO:0018685,GO:0043446,GO:0043448,GO:0044237,GO:0044248,GO:0055114,GO:0071704,GO:1901575	1.14.15.3	ko:K00496	ko00071,ko00930,map00071,map00930	-	R01347,R02281,R06945	RC00478	ko00000,ko00001,ko01000	-	-	-	FA_desaturase
SHD2_k127_205705_30	402881.Plav_2129	2.694e-36	145.0	COG1309@1|root,COG1309@2|Bacteria,1N3KN@1224|Proteobacteria,2UI3H@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
SHD2_k127_205705_4	1088721.NSU_2306	4.488e-166	532.0	COG2159@1|root,COG2159@2|Bacteria,1NRAP@1224|Proteobacteria,2UPI8@28211|Alphaproteobacteria,2K8NM@204457|Sphingomonadales	204457|Sphingomonadales	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
SHD2_k127_205705_6	1230476.C207_00464	1.007e-135	439.0	COG2070@1|root,COG2070@2|Bacteria,1MU0U@1224|Proteobacteria,2TRZS@28211|Alphaproteobacteria,3JXCN@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Nitronate monooxygenase	-	-	1.13.12.16	ko:K00459	ko00910,map00910	-	R00025	RC02541,RC02759	ko00000,ko00001,ko01000	-	-	-	NMO
SHD2_k127_205705_9	1297865.APJD01000007_gene2054	1.217e-114	376.0	COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,2TRIH@28211|Alphaproteobacteria,3JXTE@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
SHD2_k127_205705_7	1230476.C207_00462	2.284e-122	400.0	COG1028@1|root,COG1028@2|Bacteria,1MU32@1224|Proteobacteria,2TUYY@28211|Alphaproteobacteria,3JUT8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IQ	KR domain	-	GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
SHD2_k127_205705_1	1230476.C207_00461	8.473e-226	709.0	COG0318@1|root,COG0318@2|Bacteria,1QCB3@1224|Proteobacteria,2UPUU@28211|Alphaproteobacteria,3K3RB@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
SHD2_k127_205705_27	1429916.X566_02960	4.722e-48	179.0	COG1309@1|root,COG1309@2|Bacteria,1N6HV@1224|Proteobacteria,2UEX2@28211|Alphaproteobacteria,3K0FR@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	BetI-type transcriptional repressor, C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_6,TetR_N
SHD2_k127_205705_32	1230476.C207_00459	1.906e-30	128.0	COG1545@1|root,COG1545@2|Bacteria,1NEYJ@1224|Proteobacteria,2UT8K@28211|Alphaproteobacteria,3K4B5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	DUF35 OB-fold domain, acyl-CoA-associated	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_205705_5	1297865.APJD01000007_gene2049	1.132e-164	525.0	COG0183@1|root,COG0183@2|Bacteria,1R6QE@1224|Proteobacteria,2U227@28211|Alphaproteobacteria,3JVS0@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Thiolase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Thiolase_C,Thiolase_N
SHD2_k127_205705_41	1479237.JMLY01000001_gene2086	4.783e-07	60.0	COG5549@1|root,COG5549@2|Bacteria,1RIJW@1224|Proteobacteria,1SIG8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Zinc-dependent metalloprotease	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M10
SHD2_k127_205705_43	1121033.AUCF01000004_gene5024	1.538e-05	55.0	2DT0A@1|root,33I5G@2|Bacteria,1NHN4@1224|Proteobacteria,2UMA3@28211|Alphaproteobacteria,2JUKU@204441|Rhodospirillales	204441|Rhodospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_205705_14	1110502.TMO_2059	5.154e-86	291.0	COG0745@1|root,COG0745@2|Bacteria,1R8HB@1224|Proteobacteria,2U14Y@28211|Alphaproteobacteria,2JR30@204441|Rhodospirillales	204441|Rhodospirillales	T	Transcriptional regulatory protein, C terminal	-	-	-	ko:K14981	ko02020,map02020	M00520	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
SHD2_k127_205705_11	414684.RC1_0501	2.808e-107	368.0	COG0642@1|root,COG2205@2|Bacteria,1QZTV@1224|Proteobacteria,2U2P8@28211|Alphaproteobacteria,2JQU7@204441|Rhodospirillales	204441|Rhodospirillales	T	Histidine kinase-like ATPases	-	-	2.7.13.3	ko:K14980	ko02020,map02020	M00520	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c
SHD2_k127_205705_38	1122218.KB893653_gene1361	2.741e-16	86.0	COG5388@1|root,COG5388@2|Bacteria,1MXF0@1224|Proteobacteria,2U3WI@28211|Alphaproteobacteria,1JT12@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	PAS domain	MA20_31625	-	-	-	-	-	-	-	-	-	-	-	PAS_5
SHD2_k127_205705_28	1282876.BAOK01000001_gene2854	3.382e-43	170.0	COG0589@1|root,COG0589@2|Bacteria,1QD8E@1224|Proteobacteria,2TVV1@28211|Alphaproteobacteria,4BTDV@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
SHD2_k127_205705_39	652103.Rpdx1_3865	3.653e-13	74.0	2DDX0@1|root,32U27@2|Bacteria,1N2PV@1224|Proteobacteria,2U67F@28211|Alphaproteobacteria,3JYJV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_205705_29	1282876.BAOK01000001_gene2854	8.874e-41	163.0	COG0589@1|root,COG0589@2|Bacteria,1QD8E@1224|Proteobacteria,2TVV1@28211|Alphaproteobacteria,4BTDV@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
SHD2_k127_205705_0	1121405.dsmv_3031	5.264e-296	932.0	COG0045@1|root,COG0454@1|root,COG1042@1|root,COG0045@2|Bacteria,COG0456@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,42KZW@68525|delta/epsilon subdivisions,2WIQB@28221|Deltaproteobacteria,2MN5Z@213118|Desulfobacterales	28221|Deltaproteobacteria	CK	Acetyltransferase (GNAT) domain	-	-	6.2.1.13	ko:K01905,ko:K09181,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
SHD2_k127_205705_20	450851.PHZ_c2793	1.83e-58	209.0	COG2249@1|root,COG2249@2|Bacteria,1MUHN@1224|Proteobacteria,2U9KV@28211|Alphaproteobacteria,2KGVK@204458|Caulobacterales	204458|Caulobacterales	S	Flavodoxin-like fold	-	-	1.6.5.2	ko:K00355	ko00130,ko01110,ko05200,ko05225,ko05418,map00130,map01110,map05200,map05225,map05418	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	Flavodoxin_2
SHD2_k127_205705_34	323098.Nwi_3029	1.188e-25	118.0	COG0457@1|root,COG4249@1|root,COG0457@2|Bacteria,COG4249@2|Bacteria,1MVIW@1224|Proteobacteria,2TV3Y@28211|Alphaproteobacteria,3JRI6@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Caspase domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14,TPR_1,TPR_16,TPR_2,TPR_8
SHD2_k127_205705_22	402881.Plav_2039	1.369e-53	199.0	COG0664@1|root,COG0664@2|Bacteria,1MVGE@1224|Proteobacteria,2U36S@28211|Alphaproteobacteria,1JPCH@119043|Rhodobiaceae	28211|Alphaproteobacteria	K	helix_turn_helix, cAMP Regulatory protein	fixK	-	-	ko:K01420,ko:K15861	ko02020,map02020	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
SHD2_k127_205705_37	1040989.AWZU01000008_gene3671	7.688e-18	88.0	COG4566@1|root,COG4566@2|Bacteria,1MZ8E@1224|Proteobacteria,2UBRR@28211|Alphaproteobacteria,3JZZP@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
SHD2_k127_205705_26	1380391.JIAS01000011_gene5211	1.794e-50	186.0	COG4566@1|root,COG4566@2|Bacteria,1N6WR@1224|Proteobacteria,2TUND@28211|Alphaproteobacteria,2JSMN@204441|Rhodospirillales	204441|Rhodospirillales	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
SHD2_k127_205705_8	402881.Plav_2042	1.171e-117	389.0	COG3829@1|root,COG4191@1|root,COG3829@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TR8X@28211|Alphaproteobacteria,1JNV8@119043|Rhodobiaceae	28211|Alphaproteobacteria	T	PAS fold	-	-	2.7.13.3	ko:K14986	ko02020,map02020	M00524	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,MEDS,PAS,PAS_3,PAS_9
SHD2_k127_205705_25	748280.NH8B_2955	3.263e-51	188.0	COG2249@1|root,COG2249@2|Bacteria,1RA5X@1224|Proteobacteria,2VQSG@28216|Betaproteobacteria,2KTKU@206351|Neisseriales	206351|Neisseriales	S	Flavodoxin-like fold	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_2
SHD2_k127_205705_42	136993.KB900626_gene600	8.911e-06	52.0	COG2010@1|root,COG2010@2|Bacteria,1NBAR@1224|Proteobacteria,2UHUQ@28211|Alphaproteobacteria,370AE@31993|Methylocystaceae	28211|Alphaproteobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	cycB	GO:0005575,GO:0005623,GO:0042597,GO:0044464	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
SHD2_k127_205705_15	1089551.KE386572_gene3185	2.838e-85	300.0	COG3174@1|root,COG3174@2|Bacteria,1NDBI@1224|Proteobacteria,2U0C9@28211|Alphaproteobacteria,4BS1B@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Domain of unknown function (DUF4010)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4010,MgtC
SHD2_k127_205705_16	335659.S23_36510	4.095e-84	288.0	COG0589@1|root,COG0589@2|Bacteria,1MU8E@1224|Proteobacteria,2U1SK@28211|Alphaproteobacteria,3JTMJ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
SHD2_k127_205705_23	1116369.KB890024_gene1232	1.733e-51	187.0	arCOG05203@1|root,31A0K@2|Bacteria,1RHZR@1224|Proteobacteria,2U9JR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_205705_36	1230476.C207_05633	5.022e-19	89.0	2EQMA@1|root,33I79@2|Bacteria,1MZ61@1224|Proteobacteria,2UEZ6@28211|Alphaproteobacteria,3K0SZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	4-hydroxy-3-methylbut-2-enyl diphosphate reductase	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_205705_2	1297865.APJD01000017_gene4290	5.715e-194	617.0	COG0213@1|root,COG0213@2|Bacteria,1MV3H@1224|Proteobacteria,2TS24@28211|Alphaproteobacteria,3JQN1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	F	Thymidine phosphorylase	-	-	2.4.2.4	ko:K00758	ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219	-	R01570,R02484,R08222,R08230	RC00063	ko00000,ko00001,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3,PYNP_C
SHD2_k127_205705_12	1444711.CCJF01000003_gene87	7.45e-104	346.0	COG0462@1|root,COG0462@2|Bacteria	2|Bacteria	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	-	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran,Pribosyltran_N
SHD2_k127_205705_3	570952.ATVH01000013_gene2690	1.819e-184	591.0	COG1236@1|root,COG1236@2|Bacteria,1MUDD@1224|Proteobacteria,2TVFM@28211|Alphaproteobacteria,2JRI1@204441|Rhodospirillales	204441|Rhodospirillales	J	exonuclease of the beta-lactamase fold involved in RNA processing	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,RMMBL
SHD2_k127_205705_33	1244869.H261_16805	2.103e-30	132.0	COG0589@1|root,COG0589@2|Bacteria,1QD8E@1224|Proteobacteria,2TVV1@28211|Alphaproteobacteria,2JYT7@204441|Rhodospirillales	204441|Rhodospirillales	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
SHD2_k127_205705_19	105559.Nwat_0106	2.496e-75	285.0	COG2067@1|root,COG2067@2|Bacteria,1MUU4@1224|Proteobacteria,1RQZJ@1236|Gammaproteobacteria,1WYXF@135613|Chromatiales	135613|Chromatiales	I	PFAM membrane protein involved in aromatic hydrocarbon degradation	-	-	-	ko:K06076	-	-	-	-	ko00000,ko02000	1.B.9	-	-	Toluene_X
SHD2_k127_205705_10	1333998.M2A_2322	1.962e-111	376.0	COG0642@1|root,COG2205@2|Bacteria,1MXY0@1224|Proteobacteria,2U4WV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
SHD2_k127_205705_13	1282876.BAOK01000001_gene2454	2.55e-91	317.0	COG1352@1|root,COG1352@2|Bacteria,1R02K@1224|Proteobacteria,2TYHU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	NT	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_205705_31	1193181.BN10_1720004	2.98e-31	134.0	COG5285@1|root,COG5285@2|Bacteria	2|Bacteria	Q	dioxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	PhyH
SHD2_k127_205705_18	1320556.AVBP01000013_gene1368	1.151e-75	260.0	COG5429@1|root,COG5429@2|Bacteria,1RB45@1224|Proteobacteria,2U5EW@28211|Alphaproteobacteria,43NVA@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1223)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1223
SHD2_k127_205705_24	1449065.JMLL01000001_gene4139	2.605e-51	188.0	COG1595@1|root,COG1595@2|Bacteria,1MVS7@1224|Proteobacteria,2U0XJ@28211|Alphaproteobacteria,43Q29@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	sigD	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
SHD2_k127_205705_21	639283.Snov_2179	9.39e-54	196.0	COG4944@1|root,COG4944@2|Bacteria,1MXEV@1224|Proteobacteria,2TQKY@28211|Alphaproteobacteria,3EZVZ@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1109)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1109
SHD2_k127_205705_17	196367.JNFG01000026_gene8208	1.249e-77	267.0	COG0225@1|root,COG0225@2|Bacteria,1NC84@1224|Proteobacteria,2VKZ6@28216|Betaproteobacteria,1K04D@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA2	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
SHD2_k127_205705_35	450851.PHZ_c3143	4.611e-19	87.0	COG1073@1|root,COG1073@2|Bacteria,1QY19@1224|Proteobacteria,2TXFD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	PFAM alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
SHD2_k127_2223303_3	1220583.GOACH_43_00050	4.468e-59	207.0	COG2030@1|root,COG2030@2|Bacteria,2IK9K@201174|Actinobacteria,4GENA@85026|Gordoniaceae	201174|Actinobacteria	I	MaoC like domain	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
SHD2_k127_2223303_2	420324.KI911965_gene970	1.34e-63	223.0	COG1670@1|root,COG1670@2|Bacteria,1RHBD@1224|Proteobacteria,2U925@28211|Alphaproteobacteria,1JY09@119045|Methylobacteriaceae	28211|Alphaproteobacteria	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
SHD2_k127_2223303_4	631454.N177_3199	1.117e-58	212.0	COG0288@1|root,COG0288@2|Bacteria,1NGFN@1224|Proteobacteria,2TRPD@28211|Alphaproteobacteria,1JP58@119043|Rhodobiaceae	28211|Alphaproteobacteria	P	Carbonic anhydrase	cynT	-	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
SHD2_k127_2223303_0	1101189.AQUO01000001_gene1523	7.567e-189	595.0	COG1960@1|root,COG1960@2|Bacteria,1MVAH@1224|Proteobacteria,2TR02@28211|Alphaproteobacteria,2PWCR@265|Paracoccus	28211|Alphaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
SHD2_k127_2223303_1	113395.AXAI01000012_gene7089	1.851e-162	516.0	COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,1MU2H@1224|Proteobacteria,2TQK5@28211|Alphaproteobacteria,3JSD0@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	MA20_01050	-	1.17.1.10	ko:K15022	ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200	M00377	R00134	RC02796	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_20,Fer4_7,NADH_4Fe-4S,Pyr_redox_2,Pyr_redox_3
SHD2_k127_2254751_0	204669.Acid345_0114	4.495e-162	519.0	COG0075@1|root,COG0075@2|Bacteria,3Y3I6@57723|Acidobacteria,2JIIW@204432|Acidobacteriia	204432|Acidobacteriia	E	Aminotransferase, class V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
SHD2_k127_2254751_1	204669.Acid345_0116	4.945e-10	61.0	COG0517@1|root,COG1994@1|root,COG0517@2|Bacteria,COG1994@2|Bacteria,3Y4AH@57723|Acidobacteria,2JJ4R@204432|Acidobacteriia	204432|Acidobacteriia	K	Peptidase family M50	-	-	-	-	-	-	-	-	-	-	-	-	CBS,Peptidase_M50
SHD2_k127_2263854_2	935261.JAGL01000005_gene3284	4.274e-31	123.0	COG1053@1|root,COG1053@2|Bacteria,1QWW9@1224|Proteobacteria,2UQQQ@28211|Alphaproteobacteria,43K05@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	Glucose inhibited division protein A	-	-	-	-	-	-	-	-	-	-	-	-	FAD_oxidored
SHD2_k127_2263854_0	627192.SLG_27440	5.583e-156	509.0	COG2271@1|root,COG2271@2|Bacteria,1P24P@1224|Proteobacteria,2URTW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Major facilitator superfamily	-	-	-	ko:K08195	-	-	-	-	ko00000,ko02000	2.A.1.15	-	-	MFS_1,MFS_4,Sugar_tr
SHD2_k127_2263854_1	1088721.NSU_1209	7.886e-53	202.0	COG2199@1|root,COG2199@2|Bacteria,1QXGC@1224|Proteobacteria,2TZ3B@28211|Alphaproteobacteria,2KEQJ@204457|Sphingomonadales	204457|Sphingomonadales	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
SHD2_k127_2263854_3	1219035.NT2_06_00370	1.903e-21	99.0	2AI3K@1|root,318HD@2|Bacteria,1N501@1224|Proteobacteria,2UIA7@28211|Alphaproteobacteria,2KA7D@204457|Sphingomonadales	204457|Sphingomonadales	S	PilZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PilZ
SHD2_k127_2347214_22	402881.Plav_2954	4.861e-52	190.0	COG0366@1|root,COG0366@2|Bacteria,1MVKX@1224|Proteobacteria,2TRS3@28211|Alphaproteobacteria,1JPX7@119043|Rhodobiaceae	28211|Alphaproteobacteria	G	Alpha-amylase domain	aglA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	Alpha-amylase,DUF3459,Malt_amylase_C
SHD2_k127_2347214_30	76114.ebD53	2.95e-25	111.0	COG0822@1|root,COG0822@2|Bacteria,1RDGB@1224|Proteobacteria	1224|Proteobacteria	C	COG0822 NifU homolog involved in Fe-S cluster formation	nifU	-	-	-	-	-	-	-	-	-	-	-	NifU_N
SHD2_k127_2347214_5	1121033.AUCF01000005_gene5222	9.15e-166	537.0	COG2068@1|root,COG2068@2|Bacteria,1MW0X@1224|Proteobacteria,2TR5D@28211|Alphaproteobacteria,2JPR6@204441|Rhodospirillales	204441|Rhodospirillales	H	Probable molybdopterin binding domain	-	-	2.7.7.76	ko:K07141	ko00790,map00790	-	R11582	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
SHD2_k127_2347214_18	991905.SL003B_3002	1.929e-78	278.0	COG0642@1|root,COG2205@2|Bacteria,1MUAK@1224|Proteobacteria,2TSUC@28211|Alphaproteobacteria,4BRAH@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
SHD2_k127_2347214_17	631454.N177_2584	6.581e-98	326.0	COG0745@1|root,COG0745@2|Bacteria,1MY3D@1224|Proteobacteria,2TTKG@28211|Alphaproteobacteria,1JP0X@119043|Rhodobiaceae	28211|Alphaproteobacteria	KT	Transcriptional regulatory protein, C terminal	-	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
SHD2_k127_2347214_35	1333998.M2A_1678	4.168e-09	67.0	COG5126@1|root,COG5126@2|Bacteria,1NH5D@1224|Proteobacteria,2UF3D@28211|Alphaproteobacteria,4BT5E@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	DTZ	EF-hand, calcium binding motif	-	-	-	-	-	-	-	-	-	-	-	-	EF-hand_1,EF-hand_5
SHD2_k127_2347214_37	1282362.AEAC466_02880	1.006e-07	63.0	COG5126@1|root,COG5126@2|Bacteria,1NH5D@1224|Proteobacteria,2UJHN@28211|Alphaproteobacteria,2KJKF@204458|Caulobacterales	204458|Caulobacterales	DTZ	EF-hand domain pair	-	-	-	-	-	-	-	-	-	-	-	-	EF-hand_5
SHD2_k127_2347214_20	1333998.M2A_0568	1.163e-64	229.0	COG1975@1|root,COG1975@2|Bacteria,1MXKU@1224|Proteobacteria,2TUF3@28211|Alphaproteobacteria,4BQEV@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	O	XdhC Rossmann domain	MA20_09415	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI
SHD2_k127_2347214_28	1121033.AUCF01000001_gene2323	7.645e-36	139.0	COG1975@1|root,COG1975@2|Bacteria,1RI4U@1224|Proteobacteria,2U9FQ@28211|Alphaproteobacteria,2JTGI@204441|Rhodospirillales	204441|Rhodospirillales	O	XdhC and CoxI family	-	-	-	-	-	-	-	-	-	-	-	-	XdhC_CoxI
SHD2_k127_2347214_15	402881.Plav_2960	4.61e-99	330.0	COG1319@1|root,COG1319@2|Bacteria,1MUDB@1224|Proteobacteria,2TRA8@28211|Alphaproteobacteria,1JN92@119043|Rhodobiaceae	28211|Alphaproteobacteria	C	CO dehydrogenase flavoprotein C-terminal domain	coxM	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
SHD2_k127_2347214_19	402881.Plav_2962	1.215e-75	258.0	COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,2U5BM@28211|Alphaproteobacteria,1JNZP@119043|Rhodobiaceae	28211|Alphaproteobacteria	C	[2Fe-2S] binding domain	MA20_39435	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
SHD2_k127_2347214_34	525897.Dbac_0959	1.27e-09	63.0	COG1942@1|root,COG1942@2|Bacteria,1QA1B@1224|Proteobacteria,42XQ6@68525|delta/epsilon subdivisions,2WT6R@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Tautomerase enzyme	-	-	5.3.2.6	ko:K01821	ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220	M00569	R03966,R05389	RC01040,RC01355	ko00000,ko00001,ko00002,ko01000	-	-	-	Tautomerase
SHD2_k127_2347214_25	1121033.AUCF01000006_gene4135	1.905e-48	183.0	COG3427@1|root,COG3427@2|Bacteria,1RHUC@1224|Proteobacteria,2U9HD@28211|Alphaproteobacteria,2JSQF@204441|Rhodospirillales	204441|Rhodospirillales	S	Carbon monoxide dehydrogenase subunit G (CoxG)	-	-	-	ko:K09386	-	-	-	-	ko00000	-	-	-	COXG
SHD2_k127_2347214_21	1120956.JHZK01000018_gene2427	7.296e-54	195.0	COG1278@1|root,COG1278@2|Bacteria,1RAUE@1224|Proteobacteria,2U0S7@28211|Alphaproteobacteria,1JNXJ@119043|Rhodobiaceae	28211|Alphaproteobacteria	K	Cold shock protein domain	cspB	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
SHD2_k127_2347214_29	1205680.CAKO01000008_gene4127	5.152e-35	140.0	COG1430@1|root,COG1430@2|Bacteria,1MZBJ@1224|Proteobacteria,2UBSI@28211|Alphaproteobacteria,2JTN6@204441|Rhodospirillales	204441|Rhodospirillales	S	Uncharacterized ACR, COG1430	-	-	-	ko:K09005	-	-	-	-	ko00000	-	-	-	DUF192
SHD2_k127_2347214_27	1429916.X566_20280	1.563e-36	142.0	2C7TH@1|root,32RJS@2|Bacteria,1MZK8@1224|Proteobacteria,2UC2R@28211|Alphaproteobacteria,3JZJC@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ETC complex I subunit conserved region	MA20_30235	-	1.6.5.3	ko:K00329	ko00190,map00190	-	R11945	RC00061	ko00000,ko00001,ko01000	-	-	-	ETC_C1_NDUFA4
SHD2_k127_2347214_13	402881.Plav_0810	4.431e-109	359.0	COG1024@1|root,COG1024@2|Bacteria,1R8SP@1224|Proteobacteria,2U23F@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	5.3.3.18	ko:K15866	ko00360,ko01120,map00360,map01120	-	R09837,R09839	RC00004,RC00326,RC02689,RC03003	ko00000,ko00001,ko01000	-	-	-	ECH_1
SHD2_k127_2347214_16	1429916.X566_19830	4.848e-98	329.0	COG1024@1|root,COG1024@2|Bacteria,1MXZ2@1224|Proteobacteria,2TRQ8@28211|Alphaproteobacteria,3JVYF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	enoyl-CoA hydratase	MA20_25215	-	-	-	-	-	-	-	-	-	-	-	ECH_1
SHD2_k127_2347214_10	402881.Plav_2981	3.094e-128	422.0	COG0277@1|root,COG0277@2|Bacteria,1NB6A@1224|Proteobacteria,2U3ZG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	FAD-linked oxidoreductase	xyoA	-	1.1.3.41	ko:K00594	ko00040,ko00051,ko01100,map00040,map00051,map01100	-	R07152,R11620	RC00108,RC00133	ko00000,ko00001,ko01000	-	-	-	ALO,FAD_binding_4
SHD2_k127_2347214_26	1453503.AU05_13905	4.873e-39	149.0	COG0139@1|root,COG0139@2|Bacteria,1MW67@1224|Proteobacteria,1RMV4@1236|Gammaproteobacteria,1YJM2@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	E	Phosphoribosyl-AMP cyclohydrolase	hisI	-	3.5.4.19	ko:K01496	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04037	RC01055	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-CH
SHD2_k127_2347214_9	1282876.BAOK01000001_gene1992	5.414e-142	460.0	COG0626@1|root,COG0626@2|Bacteria,1MU9E@1224|Proteobacteria,2TS8Z@28211|Alphaproteobacteria,4BP63@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	PFAM Cys Met metabolism PLP-dependent enzyme	metC	GO:0000096,GO:0000098,GO:0000724,GO:0000725,GO:0003674,GO:0003824,GO:0004121,GO:0006082,GO:0006090,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006520,GO:0006534,GO:0006725,GO:0006790,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009093,GO:0009987,GO:0016054,GO:0016829,GO:0016846,GO:0019448,GO:0019450,GO:0019752,GO:0032787,GO:0033554,GO:0034641,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044273,GO:0044281,GO:0044282,GO:0046395,GO:0046439,GO:0046483,GO:0047804,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1990414	4.4.1.8	ko:K01760	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R00782,R01286,R02408,R04941	RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
SHD2_k127_2347214_7	861299.J421_3917	2.745e-154	502.0	COG0531@1|root,COG0531@2|Bacteria,1ZSUB@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	C-terminus of AA_permease	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
SHD2_k127_2347214_6	323097.Nham_3773	2.399e-157	510.0	COG3104@1|root,COG3104@2|Bacteria,1MW6W@1224|Proteobacteria,2U15C@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	amino acid peptide transporter	-	-	-	ko:K03305	-	-	-	-	ko00000	2.A.17	-	-	MFS_1,PTR2
SHD2_k127_2347214_24	402881.Plav_2988	1.091e-48	183.0	COG0454@1|root,COG0454@2|Bacteria,1RDGT@1224|Proteobacteria,2TRF5@28211|Alphaproteobacteria,1JQ6J@119043|Rhodobiaceae	28211|Alphaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
SHD2_k127_2347214_14	1449049.JONW01000009_gene4443	9.075e-102	342.0	COG2897@1|root,COG2897@2|Bacteria,1MW4B@1224|Proteobacteria,2TR9R@28211|Alphaproteobacteria,2KFH2@204458|Caulobacterales	204458|Caulobacterales	P	Sulfurtransferase	-	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
SHD2_k127_2347214_4	666684.AfiDRAFT_2162	1.733e-175	555.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,2TR4W@28211|Alphaproteobacteria,3JRM9@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Pyridoxal-phosphate dependent enzyme	cysB	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004124,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019344,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
SHD2_k127_2347214_33	1095769.CAHF01000011_gene2680	2.602e-11	65.0	COG0625@1|root,COG0625@2|Bacteria,1MY47@1224|Proteobacteria,2VQ03@28216|Betaproteobacteria	28216|Betaproteobacteria	O	Glutathione S-transferase	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_2,GST_C_3,GST_N,GST_N_3
SHD2_k127_2347214_0	1123503.KB908057_gene2482	4.988e-270	839.0	COG3278@1|root,COG3278@2|Bacteria,1MU18@1224|Proteobacteria,2TR2C@28211|Alphaproteobacteria,2KFC3@204458|Caulobacterales	204458|Caulobacterales	C	Belongs to the heme-copper respiratory oxidase family	ccoN	-	1.9.3.1	ko:K00404	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	COX1
SHD2_k127_2347214_12	366602.Caul_2438	1.831e-116	379.0	COG2993@1|root,COG2993@2|Bacteria,1MXEY@1224|Proteobacteria,2TRGW@28211|Alphaproteobacteria,2KFH7@204458|Caulobacterales	204458|Caulobacterales	C	TIGRFAM cytochrome c oxidase, cbb3-type, subunit II	ccoO	-	-	ko:K00405	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	FixO
SHD2_k127_2347214_32	1122963.AUHB01000002_gene1064	3.847e-14	73.0	COG4736@1|root,COG4736@2|Bacteria,1NGV0@1224|Proteobacteria,2UJBS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	PFAM Cbb3-type cytochrome oxidase component	-	-	-	ko:K00407	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	FixQ
SHD2_k127_2347214_11	633149.Bresu_2098	1.055e-116	381.0	COG2010@1|root,COG2010@2|Bacteria,1MUCW@1224|Proteobacteria,2TQW1@28211|Alphaproteobacteria,2KG0I@204458|Caulobacterales	204458|Caulobacterales	C	C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex	ccoP	-	-	ko:K00406	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	Cytochrome_CBB3,FixP_N
SHD2_k127_2347214_3	1122613.ATUP01000001_gene1109	8.742e-181	578.0	COG0348@1|root,COG0348@2|Bacteria,1MVFY@1224|Proteobacteria,2TRYB@28211|Alphaproteobacteria,43WKQ@69657|Hyphomonadaceae	28211|Alphaproteobacteria	C	Cytochrome c oxidase accessory protein	ccoG	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Fer4_18,Fer4_5,FixG_C
SHD2_k127_2347214_31	1280950.HJO_06090	5.32e-22	101.0	COG5456@1|root,COG5456@2|Bacteria,1RHKI@1224|Proteobacteria,2U9GB@28211|Alphaproteobacteria,43YIU@69657|Hyphomonadaceae	28211|Alphaproteobacteria	P	FixH	fixH	-	-	-	-	-	-	-	-	-	-	-	FixH
SHD2_k127_2347214_1	1123503.KB908057_gene2488	3.279e-183	597.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2TR80@28211|Alphaproteobacteria,2KEZ4@204458|Caulobacterales	204458|Caulobacterales	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.4	ko:K01533	-	-	R00086	RC00002	ko00000,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
SHD2_k127_2347214_36	1205680.CAKO01000002_gene2445	2.097e-08	57.0	COG3197@1|root,COG3197@2|Bacteria,1NG90@1224|Proteobacteria,2UJFJ@28211|Alphaproteobacteria,2JTTG@204441|Rhodospirillales	204441|Rhodospirillales	P	cytochrome oxidase maturation protein	-	-	-	-	-	-	-	-	-	-	-	-	FixS
SHD2_k127_2347214_8	1110502.TMO_0440	7.906e-147	477.0	COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,2TRKT@28211|Alphaproteobacteria,2JQTN@204441|Rhodospirillales	204441|Rhodospirillales	H	Belongs to the anaerobic coproporphyrinogen-III oxidase family	hemN	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
SHD2_k127_2347214_2	1282876.BAOK01000002_gene502	9.714e-182	575.0	COG0208@1|root,COG0208@2|Bacteria,1R4T3@1224|Proteobacteria,2U55H@28211|Alphaproteobacteria	28211|Alphaproteobacteria	F	P-aminobenzoate N-oxygenase AurF	-	-	-	-	-	-	-	-	-	-	-	-	AurF
SHD2_k127_2356190_0	1397527.Q670_14555	2.363e-63	219.0	COG0386@1|root,COG0386@2|Bacteria,1RD1R@1224|Proteobacteria,1S425@1236|Gammaproteobacteria,1XJU2@135619|Oceanospirillales	135619|Oceanospirillales	O	Belongs to the glutathione peroxidase family	-	-	1.11.1.9	ko:K00432	ko00480,ko00590,ko04918,map00480,map00590,map04918	-	R00274,R07034,R07035	RC00011,RC00982	ko00000,ko00001,ko01000	-	-	-	GSHPx
SHD2_k127_2356190_1	395964.KE386496_gene582	2.942e-59	217.0	COG3173@1|root,COG3173@2|Bacteria,1PN9F@1224|Proteobacteria,2UABV@28211|Alphaproteobacteria,3NBC1@45404|Beijerinckiaceae	28211|Alphaproteobacteria	S	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
SHD2_k127_2356190_3	69395.JQLZ01000006_gene2009	7.187e-39	157.0	COG1266@1|root,COG1266@2|Bacteria,1MWXT@1224|Proteobacteria,2U11K@28211|Alphaproteobacteria,2KJHM@204458|Caulobacterales	204458|Caulobacterales	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
SHD2_k127_2356190_2	402881.Plav_0399	1.006e-41	154.0	COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,2TRFZ@28211|Alphaproteobacteria,1JNDD@119043|Rhodobiaceae	28211|Alphaproteobacteria	T	Transcriptional regulatory protein, C terminal	phoB	-	-	ko:K07657	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
SHD2_k127_2379902_2	240015.ACP_2723	1.472e-54	199.0	COG3511@1|root,COG3511@2|Bacteria,3Y7KE@57723|Acidobacteria,2JMQB@204432|Acidobacteriia	204432|Acidobacteriia	M	Phosphoesterase family	-	-	3.1.3.64	ko:K21302	ko00562,ko01100,ko05152,map00562,map01100,map05152	-	-	-	ko00000,ko00001,ko01000	-	-	-	Phosphoesterase
SHD2_k127_2379902_1	1380394.JADL01000002_gene1525	9.811e-62	215.0	COG3791@1|root,COG3791@2|Bacteria,1RFBP@1224|Proteobacteria,2U7YA@28211|Alphaproteobacteria,2JUEE@204441|Rhodospirillales	204441|Rhodospirillales	S	Glutathione-dependent formaldehyde-activating enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GFA
SHD2_k127_2379902_0	1267533.KB906733_gene3597	4.974e-161	519.0	COG1520@1|root,COG1520@2|Bacteria,3Y2H2@57723|Acidobacteria,2JM3H@204432|Acidobacteriia	204432|Acidobacteriia	S	PQQ-like domain	-	-	1.1.2.6	ko:K05889	-	-	R03136	-	ko00000,ko01000	-	-	-	PQQ_3
SHD2_k127_2379902_4	404589.Anae109_2821	1.541e-24	108.0	COG3791@1|root,COG3791@2|Bacteria,1N7AZ@1224|Proteobacteria	1224|Proteobacteria	S	Glutathione-dependent formaldehyde-activating	-	-	-	-	-	-	-	-	-	-	-	-	GFA
SHD2_k127_2379902_3	1479238.JQMZ01000001_gene2493	1.415e-51	194.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	crtF	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_2,Methyltransf_23
SHD2_k127_2379902_5	114615.BRADO6807	1.211e-21	96.0	2BR85@1|root,32K6G@2|Bacteria,1P2KF@1224|Proteobacteria,2UU8D@28211|Alphaproteobacteria,3K4Q9@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_2381387_7	981327.F925_02519	1.9e-24	105.0	COG0386@1|root,COG0386@2|Bacteria,1RD1R@1224|Proteobacteria,1S425@1236|Gammaproteobacteria,3NIHD@468|Moraxellaceae	1236|Gammaproteobacteria	O	Belongs to the glutathione peroxidase family	gpo	-	1.11.1.9	ko:K00432	ko00480,ko00590,ko04918,map00480,map00590,map04918	-	R00274,R07034,R07035	RC00011,RC00982	ko00000,ko00001,ko01000	-	-	-	GSHPx
SHD2_k127_2381387_2	661478.OP10G_1921	6.002e-79	277.0	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Hydrolase_4
SHD2_k127_2381387_4	1161401.ASJA01000006_gene1879	9.747e-44	165.0	COG5352@1|root,COG5352@2|Bacteria,1RHI6@1224|Proteobacteria,2TS7F@28211|Alphaproteobacteria,43XPS@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	GcrA cell cycle regulator	gcrA	-	-	ko:K13583	ko04112,map04112	-	-	-	ko00000,ko00001	-	-	-	GcrA
SHD2_k127_2381387_0	1336243.JAEA01000010_gene3565	1.411e-175	558.0	COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,2TSGT@28211|Alphaproteobacteria,1JREK@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	TIGRFAM acetylornithine and succinylornithine aminotransferase	argD	GO:0003674,GO:0005488,GO:0005515,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
SHD2_k127_2381387_1	1122132.AQYH01000004_gene1649	3.249e-135	437.0	COG0078@1|root,COG0078@2|Bacteria,1MUFM@1224|Proteobacteria,2TR81@28211|Alphaproteobacteria,4B75Y@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
SHD2_k127_2381387_3	234267.Acid_7805	2.181e-50	181.0	COG2346@1|root,COG2346@2|Bacteria,3Y8WS@57723|Acidobacteria	57723|Acidobacteria	S	Bacterial-like globin	-	-	-	ko:K06886	-	-	-	-	ko00000	-	-	-	Bac_globin
SHD2_k127_2381387_8	450851.PHZ_c0869	8.617e-08	57.0	2EEKZ@1|root,338ET@2|Bacteria,1NCM1@1224|Proteobacteria,2UFHE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_2381387_9	1121859.KB890750_gene328	0.0007567	47.0	COG2885@1|root,COG2885@2|Bacteria,4NEGF@976|Bacteroidetes	976|Bacteroidetes	M	Belongs to the ompA family	yiaD	-	-	-	-	-	-	-	-	-	-	-	Gly-zipper_Omp,OmpA
SHD2_k127_2381387_5	1205680.CAKO01000030_gene4866	1.646e-38	155.0	2CPI3@1|root,32SJ7@2|Bacteria,1N1IR@1224|Proteobacteria,2UBVS@28211|Alphaproteobacteria,2JX60@204441|Rhodospirillales	204441|Rhodospirillales	S	Protein of unknown function (DUF992)	-	-	-	-	-	-	-	-	-	-	-	-	DUF992
SHD2_k127_2381387_6	1121861.KB899910_gene770	1.207e-27	123.0	COG2885@1|root,COG3637@1|root,COG2885@2|Bacteria,COG3637@2|Bacteria,1N6EM@1224|Proteobacteria,2U17R@28211|Alphaproteobacteria,2JRTJ@204441|Rhodospirillales	204441|Rhodospirillales	M	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl,OmpA,Surface_Ag_2
SHD2_k127_2443491_11	1038862.KB893840_gene1116	7.622e-75	256.0	COG0625@1|root,COG0625@2|Bacteria,1PA0Q@1224|Proteobacteria,2TVIC@28211|Alphaproteobacteria,3JVHC@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Glutathione S-transferase, N-terminal domain	MA20_22970	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_2,GST_N,GST_N_3
SHD2_k127_2443491_3	1122604.JONR01000034_gene399	6.373e-160	526.0	COG1633@1|root,COG3369@1|root,COG3592@1|root,COG1633@2|Bacteria,COG3369@2|Bacteria,COG3592@2|Bacteria,1RCN9@1224|Proteobacteria,1SZZ4@1236|Gammaproteobacteria,1X90I@135614|Xanthomonadales	135614|Xanthomonadales	S	Divergent 4Fe-4S mono-cluster	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_19,zf-CDGSH
SHD2_k127_2443491_16	216594.MMAR_2788	6.018e-27	115.0	2AU5M@1|root,31JSH@2|Bacteria,2IJSM@201174|Actinobacteria,239KJ@1762|Mycobacteriaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_2443491_15	670292.JH26_07140	7.559e-34	134.0	COG0346@1|root,COG0346@2|Bacteria,1N0WM@1224|Proteobacteria,2UCGS@28211|Alphaproteobacteria,1JWCK@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
SHD2_k127_2443491_7	1121106.JQKB01000013_gene5546	4.66e-97	323.0	COG3342@1|root,COG3342@2|Bacteria,1MWQT@1224|Proteobacteria,2TRJZ@28211|Alphaproteobacteria,2JWJI@204441|Rhodospirillales	204441|Rhodospirillales	S	Family of unknown function (DUF1028)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1028
SHD2_k127_2443491_14	1219375.CM002139_gene3995	4.191e-36	142.0	COG4731@1|root,COG4731@2|Bacteria,1N19Y@1224|Proteobacteria,1SBCW@1236|Gammaproteobacteria,1X71P@135614|Xanthomonadales	135614|Xanthomonadales	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF2147
SHD2_k127_2443491_0	420324.KI912060_gene5838	1.766e-317	991.0	COG2366@1|root,COG2366@2|Bacteria,1MVMH@1224|Proteobacteria,2TS4D@28211|Alphaproteobacteria,1JR0G@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	PFAM peptidase S45 penicillin amidase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
SHD2_k127_2443491_10	663610.JQKO01000001_gene1025	1.843e-78	269.0	COG1853@1|root,COG1853@2|Bacteria,1NB1B@1224|Proteobacteria,2U5NM@28211|Alphaproteobacteria,3NB22@45404|Beijerinckiaceae	28211|Alphaproteobacteria	S	Flavin reductase like domain	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
SHD2_k127_2443491_5	1298867.AUES01000064_gene45	1.952e-119	389.0	COG1024@1|root,COG1024@2|Bacteria,1Q51H@1224|Proteobacteria,2TUPH@28211|Alphaproteobacteria,3JU70@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
SHD2_k127_2443491_12	883078.HMPREF9695_03452	3.844e-64	221.0	COG0346@1|root,COG0346@2|Bacteria,1RH8G@1224|Proteobacteria,2U9BR@28211|Alphaproteobacteria,3JYZN@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	COG0346 Lactoylglutathione lyase and related lyases	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
SHD2_k127_2443491_2	1230476.C207_02365	3.277e-168	531.0	COG0625@1|root,COG0625@2|Bacteria,1MUN3@1224|Proteobacteria,2TTDF@28211|Alphaproteobacteria,3JTWQ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Glutathione S-transferase, C-terminal domain	MA20_16405	-	-	ko:K11209	-	-	-	-	ko00000,ko01000	-	-	-	GST_C,GST_C_2,GST_N
SHD2_k127_2443491_6	224911.27353607	1.03e-113	374.0	COG1028@1|root,COG1028@2|Bacteria,1MXNQ@1224|Proteobacteria,2TUHP@28211|Alphaproteobacteria,3JRVY@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	MA20_35605	-	-	-	-	-	-	-	-	-	-	-	adh_short
SHD2_k127_2443491_17	1078020.KEK_18228	4.194e-25	115.0	COG1946@1|root,COG1946@2|Bacteria,2I7KM@201174|Actinobacteria,237M9@1762|Mycobacteriaceae	201174|Actinobacteria	I	Thioesterase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT_3
SHD2_k127_2443491_13	316055.RPE_3942	3.463e-42	166.0	COG3945@1|root,COG3945@2|Bacteria,1RM01@1224|Proteobacteria,2U552@28211|Alphaproteobacteria,3JXTU@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
SHD2_k127_2443491_8	402881.Plav_1019	8.908e-88	308.0	COG2211@1|root,COG2211@2|Bacteria,1MVUM@1224|Proteobacteria,2U5GA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	MFS/sugar transport protein	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
SHD2_k127_2443491_1	1121033.AUCF01000014_gene1323	1.144e-178	602.0	COG0439@1|root,COG4799@1|root,COG0439@2|Bacteria,COG4799@2|Bacteria,1MU4H@1224|Proteobacteria,2TWYZ@28211|Alphaproteobacteria,2JZ2C@204441|Rhodospirillales	204441|Rhodospirillales	I	Biotin carboxylase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,Carboxyl_trans
SHD2_k127_2443491_4	1090320.KB900605_gene2236	4.57e-151	488.0	COG1960@1|root,COG1960@2|Bacteria,1MVJC@1224|Proteobacteria,2TUVB@28211|Alphaproteobacteria,2K24U@204457|Sphingomonadales	204457|Sphingomonadales	I	Acyl-CoA dehydrogenase, middle domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
SHD2_k127_2443491_9	237368.SCABRO_00086	1.914e-82	281.0	COG2887@1|root,COG2887@2|Bacteria	2|Bacteria	L	Belongs to the helicase family. UvrD subfamily	-	-	3.6.4.12	ko:K10742	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	AAA_24,PDDEXK_1
SHD2_k127_2443491_18	693986.MOC_5440	5.605e-20	93.0	COG3064@1|root,COG3064@2|Bacteria,1PDFZ@1224|Proteobacteria,2VBJJ@28211|Alphaproteobacteria,1JYTY@119045|Methylobacteriaceae	28211|Alphaproteobacteria	M	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_2445961_2	1037409.BJ6T_33720	2.036e-37	146.0	COG0631@1|root,COG0631@2|Bacteria,1R7UF@1224|Proteobacteria,2U450@28211|Alphaproteobacteria,3JX7F@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Protein phosphatase 2C	-	-	3.1.3.16	ko:K01090,ko:K11915,ko:K20074	ko02025,ko03070,map02025,map03070	-	-	-	ko00000,ko00001,ko01000,ko01009,ko02044	-	-	-	PP2C,PP2C_2
SHD2_k127_2445961_1	172088.AUGA01000009_gene1725	1.404e-73	253.0	COG3913@1|root,COG3913@2|Bacteria,1N01G@1224|Proteobacteria,2U7TM@28211|Alphaproteobacteria,3JXJ8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2094)	-	-	-	ko:K11890	ko02025,map02025	-	-	-	ko00000,ko00001,ko02044	-	-	-	DUF2094
SHD2_k127_2445961_0	1038866.KB902778_gene7325	1.356e-174	564.0	COG3523@1|root,COG3523@2|Bacteria,1MV3D@1224|Proteobacteria,2TSY0@28211|Alphaproteobacteria,3JU0B@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ImcF-related N-terminal domain	impL	-	-	ko:K11891	ko02025,ko03070,map02025,map03070	M00334	-	-	ko00000,ko00001,ko00002,ko02044	3.A.23.1	-	-	IcmF-related,IcmF_C,ImcF-related_N
SHD2_k127_2447813_0	1122132.AQYH01000004_gene1600	5.436e-136	441.0	COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,2TRUB@28211|Alphaproteobacteria,4B7BD@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase	dnaE2	GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496	2.7.7.7	ko:K02337,ko:K14162	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
SHD2_k127_2447813_1	330214.NIDE1481	7.163e-37	157.0	COG4993@1|root,COG4993@2|Bacteria	2|Bacteria	G	Dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_2447813_2	1123242.JH636437_gene6037	2.37e-24	108.0	COG1287@1|root,COG1287@2|Bacteria	2|Bacteria	S	oligosaccharyl transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	GT87,PMT_2
SHD2_k127_2500293_4	1163407.UU7_01237	1.467e-173	552.0	COG0624@1|root,COG0624@2|Bacteria,1MW20@1224|Proteobacteria,1RPN7@1236|Gammaproteobacteria,1X4BQ@135614|Xanthomonadales	135614|Xanthomonadales	E	peptidase M20	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
SHD2_k127_2500293_14	1040986.ATYO01000004_gene4878	4.33e-36	150.0	COG1835@1|root,COG1835@2|Bacteria,1RI29@1224|Proteobacteria,2U9U3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
SHD2_k127_2500293_0	1282876.BAOK01000002_gene102	0.0	1047.0	COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,2TQJT@28211|Alphaproteobacteria,4BP5T@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Malic enzyme, NAD binding domain	tme	-	1.1.1.40	ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200	M00169,M00172	R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	Malic_M,PTA_PTB,malic
SHD2_k127_2500293_11	1175306.GWL_02980	4.017e-81	281.0	COG0388@1|root,COG0388@2|Bacteria,1MWQG@1224|Proteobacteria,2VHZT@28216|Betaproteobacteria,476PW@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Carbon-nitrogen hydrolase	-	-	3.5.5.7	ko:K01502	ko00643,ko01120,map00643,map01120	-	R05358	RC01336	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase
SHD2_k127_2500293_1	402881.Plav_3599	4.835e-313	982.0	COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,2TQRR@28211|Alphaproteobacteria,1JNF2@119043|Rhodobiaceae	28211|Alphaproteobacteria	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
SHD2_k127_2500293_7	450851.PHZ_c0393	3.571e-109	358.0	COG0024@1|root,COG0024@2|Bacteria,1MU99@1224|Proteobacteria,2TUPP@28211|Alphaproteobacteria,2KHPS@204458|Caulobacterales	204458|Caulobacterales	E	Metallopeptidase family M24	-	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
SHD2_k127_2500293_13	1333998.M2A_0295	1.462e-42	162.0	COG0589@1|root,COG0589@2|Bacteria,1R9XB@1224|Proteobacteria,2U59E@28211|Alphaproteobacteria,4BR0J@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	T	Universal stress protein family	MA20_23830	-	-	-	-	-	-	-	-	-	-	-	Usp
SHD2_k127_2500293_15	1120705.FG95_01466	1.961e-27	116.0	COG2764@1|root,COG2764@2|Bacteria,1RF5T@1224|Proteobacteria,2VFDR@28211|Alphaproteobacteria,2K5NS@204457|Sphingomonadales	204457|Sphingomonadales	S	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
SHD2_k127_2500293_8	1116369.KB890024_gene1163	2.548e-97	329.0	arCOG11957@1|root,2Z84N@2|Bacteria,1QIVS@1224|Proteobacteria,2U486@28211|Alphaproteobacteria,43IB7@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_2500293_18	190650.CC_0730	3.037e-10	66.0	2C8F7@1|root,33A2N@2|Bacteria,1NH9E@1224|Proteobacteria,2UJFC@28211|Alphaproteobacteria,2KHJ3@204458|Caulobacterales	204458|Caulobacterales	S	Hypoxia induced protein conserved region	-	-	-	-	-	-	-	-	-	-	-	-	HIG_1_N
SHD2_k127_2500293_3	1121033.AUCF01000007_gene5876	1.515e-225	706.0	COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,2TR6K@28211|Alphaproteobacteria,2JQ8V@204441|Rhodospirillales	204441|Rhodospirillales	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
SHD2_k127_2500293_2	402881.Plav_1460	3.271e-263	829.0	COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,2TQTQ@28211|Alphaproteobacteria,1JN45@119043|Rhodobiaceae	28211|Alphaproteobacteria	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C
SHD2_k127_2500293_9	1280950.HJO_10832	2.527e-93	313.0	COG0176@1|root,COG0176@2|Bacteria,1MWQ8@1224|Proteobacteria,2TQJB@28211|Alphaproteobacteria,43WH7@69657|Hyphomonadaceae	28211|Alphaproteobacteria	G	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	GO:0003674,GO:0003824,GO:0006002,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016830,GO:0016832,GO:0019637,GO:0044237,GO:0071704,GO:1901135	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
SHD2_k127_2500293_19	414684.RC1_2256	1.261e-06	59.0	COG3159@1|root,COG3159@2|Bacteria,1NEKF@1224|Proteobacteria,2TV4V@28211|Alphaproteobacteria,2JSBX@204441|Rhodospirillales	204441|Rhodospirillales	S	protein conserved in bacteria	-	-	-	ko:K09921	-	-	-	-	ko00000	-	-	-	DUF484
SHD2_k127_2500293_10	1532558.JL39_25195	5.504e-91	309.0	COG4974@1|root,COG4974@2|Bacteria,1QU6A@1224|Proteobacteria,2TS7W@28211|Alphaproteobacteria,4BNRX@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	Belongs to the 'phage' integrase family. XerC subfamily	xerC	-	-	ko:K03733	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
SHD2_k127_2500293_12	402881.Plav_2503	2.306e-75	269.0	COG0477@1|root,COG2814@2|Bacteria,1MVZI@1224|Proteobacteria,2U5H1@28211|Alphaproteobacteria,1JQEM@119043|Rhodobiaceae	28211|Alphaproteobacteria	EGP	MFS_1 like family	-	-	-	ko:K05820	-	-	-	-	ko00000,ko02000	2.A.1.27	-	-	MFS_1_like
SHD2_k127_2500293_16	402881.Plav_2502	1.995e-16	89.0	2EGAZ@1|root,33A2U@2|Bacteria,1NMCB@1224|Proteobacteria,2UMCZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_2500293_6	402881.Plav_2501	1.247e-122	404.0	COG3173@1|root,COG3173@2|Bacteria,1MWAK@1224|Proteobacteria,2U36X@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
SHD2_k127_2500293_5	1333998.M2A_1301	1.124e-150	487.0	2DB8I@1|root,2Z7RY@2|Bacteria,1MY4M@1224|Proteobacteria,2U2A8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_2500293_20	1208323.B30_03667	2.795e-05	50.0	COG1309@1|root,COG1309@2|Bacteria,1MVQV@1224|Proteobacteria,2TRPA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	tetR family	MA20_09445	-	-	-	-	-	-	-	-	-	-	-	TetR_C_11,TetR_N
SHD2_k127_2500293_17	435908.IDSA_05535	4.076e-11	68.0	2DSNB@1|root,33GSA@2|Bacteria	2|Bacteria	S	Restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Mrr_cat
SHD2_k127_2584915_2	1122919.KB905548_gene2309	2.507e-08	64.0	2DN86@1|root,32W1X@2|Bacteria,1VA8R@1239|Firmicutes,4HN75@91061|Bacilli,26VAJ@186822|Paenibacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_2586862_17	1121106.JQKB01000003_gene2650	9.926e-06	53.0	COG3827@1|root,COG3827@2|Bacteria,1MX61@1224|Proteobacteria,2TSG8@28211|Alphaproteobacteria,2JT2F@204441|Rhodospirillales	204441|Rhodospirillales	S	Protein conserved in bacteria	-	-	-	ko:K09991	-	-	-	-	ko00000	-	-	-	DUF2497
SHD2_k127_2586862_0	1121033.AUCF01000001_gene2234	0.0	1105.0	COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,2TS9E@28211|Alphaproteobacteria,2JQ5V@204441|Rhodospirillales	204441|Rhodospirillales	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
SHD2_k127_2586862_1	582899.Hden_1253	1.237e-288	894.0	COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,2TRTQ@28211|Alphaproteobacteria,3N6G7@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Belongs to the IlvD Edd family	ilvD	GO:0003674,GO:0003824,GO:0004160,GO:0016829,GO:0016835,GO:0016836	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
SHD2_k127_2586862_14	1040986.ATYO01000004_gene4794	1.129e-20	102.0	2F79D@1|root,33ZQM@2|Bacteria,1NYZF@1224|Proteobacteria,2UTD5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_2586862_12	1207058.L53_11265	5.145e-43	160.0	2E1KM@1|root,32WY3@2|Bacteria,1N5IW@1224|Proteobacteria,2UDKY@28211|Alphaproteobacteria,43ZXA@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	Methylmuconolactone methyl-isomerase	-	-	-	-	-	-	-	-	-	-	-	-	EthD
SHD2_k127_2586862_11	1453501.JELR01000001_gene2770	5.227e-61	214.0	COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,1S3RP@1236|Gammaproteobacteria,466WN@72275|Alteromonadaceae	1236|Gammaproteobacteria	C	COG2080 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS CutS homologs	-	-	1.3.99.16	ko:K07302	-	-	-	-	ko00000,ko01000	-	-	-	Fer2,Fer2_2
SHD2_k127_2586862_2	1333998.M2A_2806	8.121e-220	707.0	COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2TQVK@28211|Alphaproteobacteria,4BR9M@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	iorB	-	1.3.99.16	ko:K07303	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C2
SHD2_k127_2586862_3	366602.Caul_2542	1.204e-147	479.0	COG2355@1|root,COG2355@2|Bacteria,1MWEW@1224|Proteobacteria,2TR5C@28211|Alphaproteobacteria,2KI2D@204458|Caulobacterales	204458|Caulobacterales	E	PFAM peptidase M19 renal dipeptidase	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
SHD2_k127_2586862_16	1168059.KB899087_gene1061	5.545e-07	54.0	COG1961@1|root,COG1961@2|Bacteria,1MWCZ@1224|Proteobacteria,2TRIY@28211|Alphaproteobacteria,3F0VP@335928|Xanthobacteraceae	28211|Alphaproteobacteria	L	Resolvase, N terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
SHD2_k127_2586862_13	1122962.AULH01000006_gene3222	1.493e-22	107.0	28I3D@1|root,2Z876@2|Bacteria,1P0DR@1224|Proteobacteria,2TTG2@28211|Alphaproteobacteria,36YBT@31993|Methylocystaceae	28211|Alphaproteobacteria	S	PFAM type IV pilus assembly PilZ	MA20_31715	-	-	-	-	-	-	-	-	-	-	-	PilZ
SHD2_k127_2586862_7	582402.Hbal_1243	3.209e-83	291.0	COG5330@1|root,COG5330@2|Bacteria,1R3VY@1224|Proteobacteria,2TUQ8@28211|Alphaproteobacteria,43XXH@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	Uncharacterised protein conserved in bacteria (DUF2336)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2336
SHD2_k127_2586862_9	1150626.PHAMO_580051	9.409e-68	241.0	COG0797@1|root,COG3087@1|root,COG0797@2|Bacteria,COG3087@2|Bacteria,1MZ8S@1224|Proteobacteria,2TUER@28211|Alphaproteobacteria,2JQ68@204441|Rhodospirillales	204441|Rhodospirillales	M	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	rlpA	-	-	ko:K03642	-	-	-	-	ko00000	-	-	-	DPBB_1,SPOR
SHD2_k127_2586862_4	1123355.JHYO01000006_gene2279	3.169e-106	357.0	COG1686@1|root,COG1686@2|Bacteria,1MUU7@1224|Proteobacteria,2TS1P@28211|Alphaproteobacteria,36X55@31993|Methylocystaceae	28211|Alphaproteobacteria	M	Penicillin-binding protein 5, C-terminal domain	dacC	-	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	PBP5_C,Peptidase_S11
SHD2_k127_2586862_8	1238182.C882_3886	4.097e-68	240.0	COG0125@1|root,COG0125@2|Bacteria,1MV9C@1224|Proteobacteria,2U72D@28211|Alphaproteobacteria,2JRSW@204441|Rhodospirillales	204441|Rhodospirillales	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
SHD2_k127_2586862_10	1282876.BAOK01000001_gene2131	1.259e-65	237.0	COG0470@1|root,COG0470@2|Bacteria,1MY1W@1224|Proteobacteria,2TV3E@28211|Alphaproteobacteria,4BQBV@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	L	DNA polymerase III, delta subunit	holB	-	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2
SHD2_k127_2586862_5	1205680.CAKO01000009_gene4038	1.498e-102	341.0	COG0084@1|root,COG0084@2|Bacteria,1MUC0@1224|Proteobacteria,2TS88@28211|Alphaproteobacteria,2JR2C@204441|Rhodospirillales	204441|Rhodospirillales	L	TatD related DNase	-	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
SHD2_k127_2586862_6	402881.Plav_3115	9.188e-102	338.0	COG1235@1|root,COG1235@2|Bacteria,1MVJH@1224|Proteobacteria,2TQQN@28211|Alphaproteobacteria,1JNPI@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Beta-lactamase superfamily domain	phnP	-	3.1.4.55	ko:K06167	ko00440,map00440	-	R10205	RC00296	ko00000,ko00001,ko01000	-	-	-	Lactamase_B_2
SHD2_k127_2586862_15	1297865.APJD01000002_gene4144	2.225e-13	72.0	2AQIN@1|root,31FRE@2|Bacteria,1N1Y3@1224|Proteobacteria,2UCJH@28211|Alphaproteobacteria,3K06F@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PXPV
SHD2_k127_2734640_7	411467.BACCAP_04464	3.436e-15	78.0	2EPJ6@1|root,33H5U@2|Bacteria	2|Bacteria	S	Unextendable partial coding region	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_2734640_8	1150469.RSPPHO_02107	1.112e-06	57.0	COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,2TR6F@28211|Alphaproteobacteria,2JR6A@204441|Rhodospirillales	204441|Rhodospirillales	C	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle	ppc	-	4.1.1.31	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00168,M00170,M00171,M00172,M00173,M00346,M00374	R00345	RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPcase
SHD2_k127_2734640_2	1380394.JADL01000009_gene3308	1.258e-79	276.0	28JPA@1|root,2Z9FC@2|Bacteria,1PN1F@1224|Proteobacteria,2TSKX@28211|Alphaproteobacteria,2JUBG@204441|Rhodospirillales	204441|Rhodospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_2734640_9	485913.Krac_4888	0.0002615	48.0	COG0457@1|root,COG0457@2|Bacteria	485913.Krac_4888|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_2734640_3	1286093.C266_21539	4.097e-69	239.0	COG1225@1|root,COG1225@2|Bacteria,1RHSM@1224|Proteobacteria,2VQNM@28216|Betaproteobacteria,1K3NB@119060|Burkholderiaceae	28216|Betaproteobacteria	O	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	bcp_2	-	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	AhpC-TSA
SHD2_k127_2734640_5	420324.KI912026_gene5035	1.618e-49	180.0	2BYYX@1|root,32UJT@2|Bacteria,1R4FM@1224|Proteobacteria,2U390@28211|Alphaproteobacteria,1JVUQ@119045|Methylobacteriaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_2734640_6	1040989.AWZU01000031_gene3918	2.12e-32	131.0	COG0346@1|root,COG0346@2|Bacteria,1N7R0@1224|Proteobacteria,2U65K@28211|Alphaproteobacteria,3JY8W@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
SHD2_k127_2734640_0	1333998.M2A_2717	9.346e-233	728.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,4BRSC@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Aldehyde dehydrogenase family	MA20_17005	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
SHD2_k127_2734640_1	648885.KB316283_gene4142	1.271e-83	281.0	COG0231@1|root,COG0231@2|Bacteria,1MW2J@1224|Proteobacteria,2TUWE@28211|Alphaproteobacteria,1JRWY@119045|Methylobacteriaceae	28211|Alphaproteobacteria	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	efp	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
SHD2_k127_2734640_4	1123261.AXDW01000004_gene2719	1.141e-60	223.0	COG3239@1|root,COG3239@2|Bacteria,1MY4I@1224|Proteobacteria,1S6MX@1236|Gammaproteobacteria,1X888@135614|Xanthomonadales	135614|Xanthomonadales	I	Fatty acid desaturase	-	-	-	-	-	-	-	-	-	-	-	-	FA_desaturase
SHD2_k127_2907625_1	402881.Plav_2403	7.868e-205	645.0	COG1410@1|root,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,2TQTG@28211|Alphaproteobacteria,1JN1H@119043|Rhodobiaceae	28211|Alphaproteobacteria	E	B12 binding domain	metH	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008270,GO:0008276,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019538,GO:0019752,GO:0019842,GO:0031419,GO:0032259,GO:0034641,GO:0035999,GO:0036094,GO:0036211,GO:0042084,GO:0042558,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0050667,GO:0051186,GO:0071704,GO:0097159,GO:0140096,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
SHD2_k127_2907625_19	1545915.JROG01000004_gene2348	1.475e-53	202.0	COG1028@1|root,COG1028@2|Bacteria,1RHYX@1224|Proteobacteria,2TUR9@28211|Alphaproteobacteria,2K4MT@204457|Sphingomonadales	204457|Sphingomonadales	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
SHD2_k127_2907625_0	1238182.C882_3564	0.0	1367.0	COG0145@1|root,COG0146@1|root,COG0145@2|Bacteria,COG0146@2|Bacteria,1MU2Y@1224|Proteobacteria,2TQZ6@28211|Alphaproteobacteria,2JQPR@204441|Rhodospirillales	204441|Rhodospirillales	EQ	Hydantoinase/oxoprolinase N-terminal region	-	-	3.5.2.9	ko:K01469	ko00480,map00480	-	R00251	RC00553	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A,Hydantoinase_B
SHD2_k127_2907625_14	1282876.BAOK01000001_gene1347	1.27e-78	274.0	COG1076@1|root,COG1076@2|Bacteria,1N270@1224|Proteobacteria,2TTX1@28211|Alphaproteobacteria,4BQDX@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	O	Tellurite resistance protein TerB	djlA	-	-	ko:K05801	-	-	-	-	ko00000,ko03110	-	-	-	DnaJ,TerB
SHD2_k127_2907625_22	402881.Plav_0119	5.08e-23	104.0	2CF37@1|root,2ZX4J@2|Bacteria,1P5D2@1224|Proteobacteria	1224|Proteobacteria	S	Ribbon-helix-helix protein, copG family	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1
SHD2_k127_2907625_17	1231190.NA8A_07649	3.047e-63	228.0	COG2375@1|root,COG2375@2|Bacteria,1R4TD@1224|Proteobacteria,2U6G4@28211|Alphaproteobacteria,43JGW@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	Siderophore-interacting protein	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_9,SIP
SHD2_k127_2907625_15	1121861.KB899923_gene3405	4.234e-76	263.0	COG3023@1|root,COG3023@2|Bacteria,1RDHU@1224|Proteobacteria,2TSW3@28211|Alphaproteobacteria,2JRTC@204441|Rhodospirillales	204441|Rhodospirillales	V	COG3023 Negative regulator of beta-lactamase expression	-	-	3.5.1.28	ko:K01447	-	-	R04112	RC00064,RC00141	ko00000,ko01000	-	-	-	Amidase_2,PG_binding_1
SHD2_k127_2907625_13	85643.Tmz1t_3053	8.852e-80	272.0	COG1794@1|root,COG1794@2|Bacteria,1MV03@1224|Proteobacteria,2VHS8@28216|Betaproteobacteria,2KXI9@206389|Rhodocyclales	206389|Rhodocyclales	M	Belongs to the aspartate glutamate racemases family	-	-	5.1.1.13	ko:K01779	ko00250,ko01054,map00250,map01054	-	R00491	RC00302	ko00000,ko00001,ko01000	-	-	-	Asp_Glu_race
SHD2_k127_2907625_20	1429916.X566_03460	2.22e-34	137.0	COG0454@1|root,COG0454@2|Bacteria,1QUQU@1224|Proteobacteria,2TXUA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10
SHD2_k127_2907625_23	1082931.KKY_2008	2.146e-21	97.0	2DQNQ@1|root,337TP@2|Bacteria,1NFYG@1224|Proteobacteria,2UFD8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_2907625_18	441620.Mpop_0685	2.586e-57	202.0	COG5579@1|root,COG5579@2|Bacteria,1RGXV@1224|Proteobacteria,2U9EH@28211|Alphaproteobacteria,1JUSD@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1810)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1810
SHD2_k127_2907625_4	392499.Swit_4612	1.592e-163	537.0	COG1680@1|root,COG1680@2|Bacteria,1PQ2Z@1224|Proteobacteria,2U1GN@28211|Alphaproteobacteria,2K210@204457|Sphingomonadales	204457|Sphingomonadales	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
SHD2_k127_2907625_16	1122970.AUHC01000001_gene716	8.692e-65	224.0	COG1720@1|root,COG1720@2|Bacteria,1Q67Y@1224|Proteobacteria,2VCES@28211|Alphaproteobacteria,2KA5R@204457|Sphingomonadales	204457|Sphingomonadales	S	Uncharacterised protein family UPF0066	-	-	-	-	-	-	-	-	-	-	-	-	UPF0066
SHD2_k127_2907625_21	1397666.RS24_00707	3.918e-27	116.0	COG2001@1|root,COG2001@2|Bacteria,1RHCG@1224|Proteobacteria,2UD3W@28211|Alphaproteobacteria,4BQSM@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	K	MraZ protein, putative antitoxin-like	mraZ	-	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
SHD2_k127_2907625_10	570967.JMLV01000006_gene235	6.094e-99	331.0	COG0275@1|root,COG0275@2|Bacteria,1MUT4@1224|Proteobacteria,2TRQA@28211|Alphaproteobacteria,2JPTV@204441|Rhodospirillales	204441|Rhodospirillales	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	-	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
SHD2_k127_2907625_24	402881.Plav_2414	1.405e-06	55.0	COG5462@1|root,COG5462@2|Bacteria,1N0IS@1224|Proteobacteria,2UC96@28211|Alphaproteobacteria,1JPI8@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	secreted (periplasmic) protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_2907625_7	1161401.ASJA01000001_gene387	1.443e-123	415.0	COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,2TSHQ@28211|Alphaproteobacteria,43WZ2@69657|Hyphomonadaceae	28211|Alphaproteobacteria	M	COG0768 Cell division protein FtsI penicillin-binding protein 2	ftsI	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PBP_dimer,Transpeptidase
SHD2_k127_2907625_3	402881.Plav_2416	9.493e-166	534.0	COG0769@1|root,COG0769@2|Bacteria,1MU6P@1224|Proteobacteria,2TVXI@28211|Alphaproteobacteria,1JMYZ@119043|Rhodobiaceae	28211|Alphaproteobacteria	M	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
SHD2_k127_2907625_8	316057.RPD_3398	1.705e-122	407.0	COG0770@1|root,COG0770@2|Bacteria,1QTSF@1224|Proteobacteria,2TR0Q@28211|Alphaproteobacteria,3JT30@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10,6.3.2.13	ko:K01928,ko:K01929,ko:K15792	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R02788,R04573,R04617	RC00064,RC00090,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
SHD2_k127_2907625_5	570952.ATVH01000014_gene2081	3.374e-146	471.0	COG0472@1|root,COG0472@2|Bacteria,1MUTK@1224|Proteobacteria,2TRUG@28211|Alphaproteobacteria,2JQ3T@204441|Rhodospirillales	204441|Rhodospirillales	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
SHD2_k127_2907625_6	709797.CSIRO_4075	2.814e-141	465.0	COG0771@1|root,COG0771@2|Bacteria,1MVYD@1224|Proteobacteria,2TTE8@28211|Alphaproteobacteria,3JSWK@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase_C,Mur_ligase_M
SHD2_k127_2907625_11	391937.NA2_00455	6.031e-91	314.0	COG0772@1|root,COG0772@2|Bacteria,1MVDB@1224|Proteobacteria,2TQSA@28211|Alphaproteobacteria,43IVE@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	D	Belongs to the SEDS family	ftsW	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
SHD2_k127_2907625_9	991905.SL003B_1347	4.985e-102	344.0	COG0707@1|root,COG0707@2|Bacteria,1MVIB@1224|Proteobacteria,2TSEY@28211|Alphaproteobacteria,4BPZ1@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
SHD2_k127_2907625_2	1333998.M2A_1375	4.417e-193	614.0	COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,2TRT0@28211|Alphaproteobacteria,4BP57@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
SHD2_k127_2907625_12	1238182.C882_0075	1.919e-90	306.0	COG0812@1|root,COG0812@2|Bacteria,1MXDH@1224|Proteobacteria,2TRQR@28211|Alphaproteobacteria,2JPRS@204441|Rhodospirillales	204441|Rhodospirillales	M	Cell wall formation	murB	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
SHD2_k127_3243557_12	1122137.AQXF01000004_gene1584	1.317e-139	463.0	COG4774@1|root,COG4774@2|Bacteria,1NMCN@1224|Proteobacteria,2U1C8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
SHD2_k127_3243557_20	566466.NOR53_3212	7.279e-87	312.0	COG1414@1|root,COG1414@2|Bacteria,1QYTM@1224|Proteobacteria,1RUTM@1236|Gammaproteobacteria,1J6BQ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	K	transcriptional regulator	-	-	-	ko:K02624	-	-	-	-	ko00000,ko03000	-	-	-	HTH_IclR,IclR
SHD2_k127_3243557_7	1248917.ANFX01000040_gene766	1.116e-171	543.0	COG0620@1|root,COG0620@2|Bacteria,1MUI9@1224|Proteobacteria,2TTWK@28211|Alphaproteobacteria,2K3CA@204457|Sphingomonadales	204457|Sphingomonadales	E	Cobalamin-independent synthase, Catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Meth_synt_2
SHD2_k127_3243557_33	1122201.AUAZ01000027_gene2204	8.511e-55	200.0	COG2021@1|root,COG2021@2|Bacteria,1RDEH@1224|Proteobacteria,1T1N9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4,Abhydrolase_6,Hydrolase_4
SHD2_k127_3243557_46	298653.Franean1_5788	4.576e-22	104.0	COG2514@1|root,COG2514@2|Bacteria,2GUZK@201174|Actinobacteria	201174|Actinobacteria	S	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	1.13.11.2	ko:K07104	ko00361,ko00362,ko00622,ko00643,ko01100,ko01120,ko01220,map00361,map00362,map00622,map00643,map01100,map01120,map01220	M00569	R00816,R04089,R05295,R05404,R05406,R07795	RC00387,RC00643,RC01075,RC01364,RC01914	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase
SHD2_k127_3243557_26	504832.OCAR_6798	3.99e-71	252.0	COG0589@1|root,COG0589@2|Bacteria,1MU8E@1224|Proteobacteria,2U1SK@28211|Alphaproteobacteria,3JTMJ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
SHD2_k127_3243557_45	717785.HYPMC_0223	6.756e-24	109.0	2DNEG@1|root,32X40@2|Bacteria,1R7P4@1224|Proteobacteria	1224|Proteobacteria	S	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	LTXXQ
SHD2_k127_3243557_25	1205680.CAKO01000014_gene96	1.037e-80	274.0	COG0500@1|root,COG0500@2|Bacteria,1REJ2@1224|Proteobacteria,2U7T5@28211|Alphaproteobacteria,2JSZ5@204441|Rhodospirillales	204441|Rhodospirillales	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
SHD2_k127_3243557_27	1280946.HY29_03830	2.807e-67	253.0	COG1629@1|root,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,2TXAG@28211|Alphaproteobacteria,440ZA@69657|Hyphomonadaceae	28211|Alphaproteobacteria	P	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
SHD2_k127_3243557_31	493475.GARC_4753	1.39e-58	213.0	COG1629@1|root,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,1RNWV@1236|Gammaproteobacteria,4660S@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	TonB-dependent Receptor Plug Domain	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
SHD2_k127_3243557_11	1449353.JQMQ01000005_gene1522	5.687e-145	473.0	COG0531@1|root,COG0531@2|Bacteria,2GNUF@201174|Actinobacteria,2NNC1@228398|Streptacidiphilus	201174|Actinobacteria	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease,AA_permease_2
SHD2_k127_3243557_9	366602.Caul_1195	5.967e-165	540.0	COG1506@1|root,COG1506@2|Bacteria,1MUJ3@1224|Proteobacteria,2TUZZ@28211|Alphaproteobacteria,2KFCI@204458|Caulobacterales	204458|Caulobacterales	E	Prolyl oligopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S9
SHD2_k127_3243557_4	1280949.HAD_11385	5.07e-188	596.0	COG2124@1|root,COG2124@2|Bacteria	2|Bacteria	Q	cytochrome p450	ahpG	-	-	-	-	-	-	-	-	-	-	-	p450
SHD2_k127_3243557_41	394221.Mmar10_2875	2.25e-34	140.0	COG0346@1|root,COG0346@2|Bacteria,1P3AW@1224|Proteobacteria,2V8YJ@28211|Alphaproteobacteria,44024@69657|Hyphomonadaceae	28211|Alphaproteobacteria	E	Glyoxalase-like domain	-	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
SHD2_k127_3243557_24	1333998.M2A_1721	1.123e-81	285.0	COG2267@1|root,COG2267@2|Bacteria,1MWF5@1224|Proteobacteria,2TV6U@28211|Alphaproteobacteria,4BS3R@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
SHD2_k127_3243557_23	402881.Plav_1081	3.248e-82	283.0	COG1573@1|root,COG1573@2|Bacteria,1R9XV@1224|Proteobacteria,2TSWU@28211|Alphaproteobacteria,1JNYJ@119043|Rhodobiaceae	28211|Alphaproteobacteria	L	UreE urease accessory protein, C-terminal domain	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
SHD2_k127_3243557_49	1298860.AUEM01000003_gene3711	7.903e-13	74.0	COG4374@1|root,COG4374@2|Bacteria,2GPFR@201174|Actinobacteria	201174|Actinobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
SHD2_k127_3243557_52	264198.Reut_A3454	5.871e-06	52.0	COG4691@1|root,COG4691@2|Bacteria,1N8BI@1224|Proteobacteria,2VVWB@28216|Betaproteobacteria,1KF25@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Plasmid stability protein	stbC	-	-	ko:K21495	-	-	-	-	ko00000,ko02048	-	-	-	Arc
SHD2_k127_3243557_5	1333998.M2A_1719	8.402e-186	587.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TQKE@28211|Alphaproteobacteria,4BRH9@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	ko:K06446	ko00930,ko01100,ko01120,map00930,map01100,map01120	-	R06943	RC00052	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
SHD2_k127_3243557_51	1207063.P24_15571	2.753e-09	65.0	COG5388@1|root,COG5388@2|Bacteria,1NC94@1224|Proteobacteria,2UFSI@28211|Alphaproteobacteria,2JWXQ@204441|Rhodospirillales	204441|Rhodospirillales	S	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	PAS_5
SHD2_k127_3243557_50	1380391.JIAS01000017_gene572	3.456e-10	68.0	COG5388@1|root,COG5388@2|Bacteria,1NBQ3@1224|Proteobacteria,2UGPA@28211|Alphaproteobacteria,2JWYW@204441|Rhodospirillales	204441|Rhodospirillales	S	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	PAS_5
SHD2_k127_3243557_15	1333998.M2A_1717	1.219e-124	408.0	COG2141@1|root,COG2141@2|Bacteria,1MVF0@1224|Proteobacteria,2TTR7@28211|Alphaproteobacteria,4BRF4@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
SHD2_k127_3243557_13	1282876.BAOK01000001_gene2504	1.155e-134	441.0	COG1972@1|root,COG1972@2|Bacteria,1MXXX@1224|Proteobacteria,2TU8A@28211|Alphaproteobacteria	28211|Alphaproteobacteria	F	Nucleoside transporter	MA20_32460	-	-	ko:K03317	-	-	-	-	ko00000	2.A.41	-	-	Nucleos_tra2_C,Nucleos_tra2_N
SHD2_k127_3243557_32	1346791.M529_06035	2.335e-56	203.0	COG3201@1|root,COG3201@2|Bacteria,1MXN4@1224|Proteobacteria,2UAA3@28211|Alphaproteobacteria,2K4GB@204457|Sphingomonadales	204457|Sphingomonadales	H	nicotinamide mononucleotide transporter	-	-	-	ko:K03811	-	-	-	-	ko00000,ko02000	4.B.1.1	-	-	NMN_transporter
SHD2_k127_3243557_38	629773.AORY01000012_gene941	3.847e-41	158.0	COG3172@1|root,COG3172@2|Bacteria,1MUSI@1224|Proteobacteria,2UAKD@28211|Alphaproteobacteria,2K65Q@204457|Sphingomonadales	204457|Sphingomonadales	H	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_28
SHD2_k127_3243557_44	1121124.JNIX01000010_gene726	6.604e-25	118.0	COG1835@1|root,COG1835@2|Bacteria,1N2Z2@1224|Proteobacteria	1224|Proteobacteria	I	Acyl-transferase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
SHD2_k127_3243557_14	1382303.JPOM01000001_gene862	4.266e-129	419.0	COG1028@1|root,COG1028@2|Bacteria,1MXNQ@1224|Proteobacteria,2TS6G@28211|Alphaproteobacteria,2KFIJ@204458|Caulobacterales	204458|Caulobacterales	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
SHD2_k127_3243557_22	450851.PHZ_c0106	6.398e-86	292.0	COG0346@1|root,COG0346@2|Bacteria,1MXZ4@1224|Proteobacteria,2TUBZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Glyoxalase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase,Glyoxalase_3,Glyoxalase_4
SHD2_k127_3243557_6	582402.Hbal_0949	1.63e-174	563.0	COG2304@1|root,COG2304@2|Bacteria,1MUTS@1224|Proteobacteria,2TSQU@28211|Alphaproteobacteria,43X5H@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	von Willebrand factor, type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	DUF3520,VWA,vWF_A
SHD2_k127_3243557_21	1207063.P24_15524	2.142e-86	305.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2TRHH@28211|Alphaproteobacteria,2JQVJ@204441|Rhodospirillales	204441|Rhodospirillales	T	transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_7,PAS_9,Response_reg
SHD2_k127_3243557_53	1248917.ANFX01000008_gene282	1.345e-05	52.0	28ZXZ@1|root,2ZMNF@2|Bacteria,1NM5Z@1224|Proteobacteria,2UWBC@28211|Alphaproteobacteria,2K81I@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_3243557_18	1123504.JQKD01000022_gene154	1.923e-108	361.0	COG1024@1|root,COG1024@2|Bacteria,1MVQN@1224|Proteobacteria,2W2C8@28216|Betaproteobacteria	28216|Betaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	5.3.3.18	ko:K15866	ko00360,ko01120,map00360,map01120	-	R09837,R09839	RC00004,RC00326,RC02689,RC03003	ko00000,ko00001,ko01000	-	-	-	ECH_1
SHD2_k127_3243557_3	1057002.KB905370_gene5275	2.481e-206	653.0	COG2719@1|root,COG2719@2|Bacteria,1MW6U@1224|Proteobacteria,2TRJG@28211|Alphaproteobacteria,4B9K4@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	SpoVR family	-	GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0050896,GO:0051716	-	ko:K06415	-	-	-	-	ko00000	-	-	-	SpoVR
SHD2_k127_3243557_10	266779.Meso_0256	8.552e-157	505.0	COG2718@1|root,COG2718@2|Bacteria,1MWQM@1224|Proteobacteria,2TTWI@28211|Alphaproteobacteria,43GVI@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Belongs to the UPF0229 family	-	-	-	ko:K09786	-	-	-	-	ko00000	-	-	-	DUF444
SHD2_k127_3243557_0	1247963.JPHU01000003_gene1495	0.0	1081.0	COG2766@1|root,COG2766@2|Bacteria,1MVW7@1224|Proteobacteria,2TTW4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Serine protein kinase	yeaG	-	-	ko:K07180	-	-	-	-	ko00000	-	-	-	AAA_PrkA,PrkA
SHD2_k127_3243557_29	1449076.JOOE01000001_gene2129	6.143e-67	240.0	COG0682@1|root,COG0682@2|Bacteria,1MVRP@1224|Proteobacteria,2TV67@28211|Alphaproteobacteria,2K383@204457|Sphingomonadales	204457|Sphingomonadales	M	Prolipoprotein diacylglyceryl transferase	-	-	-	-	-	-	-	-	-	-	-	-	LGT
SHD2_k127_3243557_2	1380391.JIAS01000001_gene2796	9.444e-215	675.0	COG1964@1|root,COG1964@2|Bacteria,1QE02@1224|Proteobacteria,2U29I@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	4Fe-4S single cluster domain	-	-	-	ko:K06937	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Fer4_14,Radical_SAM
SHD2_k127_3243557_42	1089552.KI911559_gene1801	1.383e-31	134.0	COG1247@1|root,COG1247@2|Bacteria,1QU6B@1224|Proteobacteria,2TW1F@28211|Alphaproteobacteria,2JTBX@204441|Rhodospirillales	204441|Rhodospirillales	M	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,FR47
SHD2_k127_3243557_1	402881.Plav_3137	9.181e-255	794.0	COG3119@1|root,COG3119@2|Bacteria,1MWY7@1224|Proteobacteria,2TV04@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
SHD2_k127_3243557_48	997346.HMPREF9374_1780	1.251e-17	93.0	COG3173@1|root,COG3173@2|Bacteria,1TPYB@1239|Firmicutes,4HBYQ@91061|Bacilli,27CG9@186824|Thermoactinomycetaceae	91061|Bacilli	S	Phosphotransferase enzyme family	ycbJ	-	-	ko:K06979	-	M00760	-	-	br01600,ko00000,ko00002,ko01504	-	-	-	APH
SHD2_k127_3243557_39	794846.AJQU01000045_gene4477	2.222e-39	153.0	COG2062@1|root,COG2062@2|Bacteria,1N0FX@1224|Proteobacteria,2UBYD@28211|Alphaproteobacteria,4BF34@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	phosphohistidine phosphatase	sixA	-	-	ko:K08296	-	-	-	-	ko00000,ko01000	-	-	-	His_Phos_1
SHD2_k127_3243557_40	402881.Plav_0429	1.205e-35	142.0	COG3793@1|root,COG3793@2|Bacteria,1RD1X@1224|Proteobacteria,2U788@28211|Alphaproteobacteria,1JPBY@119043|Rhodobiaceae	28211|Alphaproteobacteria	P	PFAM Mo-dependent nitrogenase	-	-	-	-	-	-	-	-	-	-	-	-	TerB
SHD2_k127_3243557_8	1333998.M2A_2051	9.743e-166	529.0	COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,2TTMF@28211|Alphaproteobacteria,4BPGP@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide	metZ	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003962,GO:0004123,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.5.1.48	ko:K01739,ko:K10764	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00999,R01288,R02508,R03217,R03260,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00420,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
SHD2_k127_3243557_35	1121385.AQXW01000004_gene2542	8.597e-50	181.0	COG1764@1|root,COG1764@2|Bacteria,2IHT2@201174|Actinobacteria	201174|Actinobacteria	O	PFAM OsmC family protein	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,OsmC
SHD2_k127_3243557_37	1120983.KB894575_gene765	3.309e-47	173.0	COG2967@1|root,COG2967@2|Bacteria,1MZ2Z@1224|Proteobacteria,2U9JM@28211|Alphaproteobacteria,1JPB2@119043|Rhodobiaceae	28211|Alphaproteobacteria	P	ApaG domain	apaG	-	-	ko:K06195	-	-	-	-	ko00000	-	-	-	DUF525
SHD2_k127_3243557_19	1279038.KB907351_gene2769	6.686e-91	304.0	COG0302@1|root,COG0302@2|Bacteria,1MY3N@1224|Proteobacteria,2TSZI@28211|Alphaproteobacteria,2JPKI@204441|Rhodospirillales	204441|Rhodospirillales	H	GTP cyclohydrolase	folE	-	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydroI
SHD2_k127_3243557_17	331869.BAL199_10030	1.92e-110	370.0	COG0624@1|root,COG0624@2|Bacteria,1MVBR@1224|Proteobacteria,2TRUK@28211|Alphaproteobacteria,4BPSJ@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Belongs to the peptidase M20A family. ArgE subfamily	argE	-	3.5.1.16	ko:K01438	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R00669,R09107	RC00064,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
SHD2_k127_3243557_43	1120792.JAFV01000001_gene1367	1.719e-31	126.0	COG0061@1|root,COG0061@2|Bacteria,1NBI3@1224|Proteobacteria,2TUCV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	-	-	-	-	-	-	-	-	-	-	-	-	NAD_kinase
SHD2_k127_3243557_34	1333998.M2A_0572	5.663e-53	195.0	COG0346@1|root,COG0346@2|Bacteria,1N3A9@1224|Proteobacteria	1224|Proteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
SHD2_k127_3243557_36	1122214.AQWH01000010_gene2823	1.056e-48	181.0	COG1011@1|root,COG1011@2|Bacteria,1RKHU@1224|Proteobacteria,2UANU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Hydrolase	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2,Hydrolase
SHD2_k127_3243557_28	1333998.M2A_1879	3.736e-67	239.0	COG0596@1|root,COG0596@2|Bacteria,1N3G3@1224|Proteobacteria,2U1NS@28211|Alphaproteobacteria,4BSPK@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
SHD2_k127_3243557_30	402881.Plav_0404	3.231e-60	219.0	COG1281@1|root,COG1281@2|Bacteria,1MUMU@1224|Proteobacteria,2TTUR@28211|Alphaproteobacteria,1JN3M@119043|Rhodobiaceae	28211|Alphaproteobacteria	O	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress	hslO	-	-	ko:K04083	-	-	-	-	ko00000,ko03110	-	-	-	HSP33
SHD2_k127_3243557_16	713586.KB900536_gene2616	1.188e-121	402.0	COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,1RNID@1236|Gammaproteobacteria,1WXP9@135613|Chromatiales	135613|Chromatiales	M	Mycolic acid cyclopropane synthetase	-	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
SHD2_k127_3243557_47	1038859.AXAU01000001_gene3639	7.279e-18	83.0	COG0607@1|root,COG0607@2|Bacteria,1RHQZ@1224|Proteobacteria,2U9AJ@28211|Alphaproteobacteria,3JZKS@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Rhodanese-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
SHD2_k127_3270096_38	1267005.KB911257_gene692	9.828e-63	222.0	COG0644@1|root,COG0644@2|Bacteria,1Q5UG@1224|Proteobacteria,2UQI2@28211|Alphaproteobacteria,3N843@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_3270096_70	190650.CC_1472	4.797e-13	76.0	2C3EC@1|root,33W7V@2|Bacteria,1NVYE@1224|Proteobacteria,2USF2@28211|Alphaproteobacteria,2KJEN@204458|Caulobacterales	204458|Caulobacterales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_3270096_4	670292.JH26_22465	4.937e-283	893.0	COG0072@1|root,COG0072@2|Bacteria,1MWKS@1224|Proteobacteria,2TQV8@28211|Alphaproteobacteria,1JQR5@119045|Methylobacteriaceae	28211|Alphaproteobacteria	J	phenylalanyl-tRNA synthetase beta subunit	pheT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
SHD2_k127_3270096_12	639283.Snov_0314	6.195e-155	497.0	COG0016@1|root,COG0016@2|Bacteria,1MVD7@1224|Proteobacteria,2TS2T@28211|Alphaproteobacteria,3EYT0@335928|Xanthobacteraceae	28211|Alphaproteobacteria	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
SHD2_k127_3270096_47	438753.AZC_4448	2.255e-43	160.0	COG0292@1|root,COG0292@2|Bacteria,1RGU2@1224|Proteobacteria,2U756@28211|Alphaproteobacteria,3EZMD@335928|Xanthobacteraceae	28211|Alphaproteobacteria	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0006996,GO:0008150,GO:0009987,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043933,GO:0044085,GO:0065003,GO:0070925,GO:0071826,GO:0071840	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
SHD2_k127_3270096_71	1220535.IMCC14465_07150	1.494e-12	70.0	COG0291@1|root,COG0291@2|Bacteria,1N6V4@1224|Proteobacteria,2UF6K@28211|Alphaproteobacteria,4BQVU@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	J	Belongs to the bacterial ribosomal protein bL35 family	rpmI	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02916	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35p
SHD2_k127_3270096_48	930169.B5T_04398	2.302e-43	163.0	COG1970@1|root,COG1970@2|Bacteria,1RHG8@1224|Proteobacteria,1S3PD@1236|Gammaproteobacteria,1XKKT@135619|Oceanospirillales	135619|Oceanospirillales	M	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell	mscL	-	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
SHD2_k127_3270096_60	402881.Plav_2239	7.425e-24	112.0	2ERA8@1|root,33IVV@2|Bacteria,1NMXG@1224|Proteobacteria,2UKSQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_3270096_39	391165.GbCGDNIH1_2159	1.451e-61	214.0	COG0229@1|root,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,2U70T@28211|Alphaproteobacteria,2JTFN@204441|Rhodospirillales	204441|Rhodospirillales	O	SelR domain	msrB	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
SHD2_k127_3270096_40	420324.KI912045_gene4133	2.312e-60	212.0	COG1956@1|root,COG1956@2|Bacteria,1RDBM@1224|Proteobacteria,2U595@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	COG1956 GAF domain-containing protein	msrC	-	1.8.4.14	ko:K08968	ko00270,map00270	-	R02025	RC00639	ko00000,ko00001,ko01000	-	-	-	GAF_2
SHD2_k127_3270096_37	366602.Caul_2678	2.575e-64	236.0	COG0477@1|root,COG2814@2|Bacteria,1N2P7@1224|Proteobacteria,2UD1F@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EGP	Pfam Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SHD2_k127_3270096_19	349163.Acry_0514	6.885e-113	372.0	COG2267@1|root,COG2267@2|Bacteria,1QXKN@1224|Proteobacteria,2TY6F@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
SHD2_k127_3270096_51	1110502.TMO_0569	2.052e-39	151.0	COG1765@1|root,COG1765@2|Bacteria,1N2BT@1224|Proteobacteria,2TQN7@28211|Alphaproteobacteria,2JQYF@204441|Rhodospirillales	204441|Rhodospirillales	O	OsmC-like protein	-	-	-	ko:K07397	-	-	-	-	ko00000	-	-	-	OsmC
SHD2_k127_3270096_59	1280952.HJA_16555	4.657e-28	125.0	COG3735@1|root,COG3735@2|Bacteria,1MVCW@1224|Proteobacteria,2U5RA@28211|Alphaproteobacteria,43XGY@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	protein conserved in bacteria	-	-	-	ko:K09973	-	-	-	-	ko00000	-	-	-	TraB
SHD2_k127_3270096_17	1245469.S58_38830	1.105e-115	385.0	28JJ3@1|root,2Z9C7@2|Bacteria,1R3Y0@1224|Proteobacteria,2U0DT@28211|Alphaproteobacteria,3JSF4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	MA20_22330	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_3270096_43	1122604.JONR01000002_gene1587	3.385e-53	194.0	COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,1RP9U@1236|Gammaproteobacteria,1XCJ2@135614|Xanthomonadales	135614|Xanthomonadales	M	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	-	-	-	-	-	-	-	-	-	-	-	-	Pro_isomerase
SHD2_k127_3270096_55	743836.AYNA01000039_gene741	3.21e-35	140.0	COG0494@1|root,COG0494@2|Bacteria,1MZ5D@1224|Proteobacteria,2UBX9@28211|Alphaproteobacteria,370KD@31993|Methylocystaceae	28211|Alphaproteobacteria	L	COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX,PhoU_div
SHD2_k127_3270096_13	622637.KE124774_gene948	6.557e-152	486.0	COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,2TSYI@28211|Alphaproteobacteria,36XGF@31993|Methylocystaceae	28211|Alphaproteobacteria	P	Phosphate transporter family	pit	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
SHD2_k127_3270096_33	1187851.A33M_0285	5.459e-74	254.0	COG1392@1|root,COG1392@2|Bacteria,1R4SP@1224|Proteobacteria,2U5E0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	phosphate transport regulator	MA20_27875	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	NUDIX,PhoU_div
SHD2_k127_3270096_58	1120956.JHZK01000004_gene1464	3.429e-29	137.0	COG0790@1|root,COG1196@1|root,COG3409@1|root,COG0790@2|Bacteria,COG1196@2|Bacteria,COG3409@2|Bacteria,1MWPA@1224|Proteobacteria,2TR2B@28211|Alphaproteobacteria,1JNWK@119043|Rhodobiaceae	28211|Alphaproteobacteria	DM	Sel1-like repeats.	-	-	-	ko:K07126,ko:K13582	ko04112,map04112	-	-	-	ko00000,ko00001	-	-	-	PG_binding_1,Sel1
SHD2_k127_3270096_26	402881.Plav_1560	1.572e-85	295.0	COG2866@1|root,COG2866@2|Bacteria,1N6CX@1224|Proteobacteria,2U3MG@28211|Alphaproteobacteria	1224|Proteobacteria	E	Protein of unknown function (DUF2817)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2817
SHD2_k127_3270096_29	551275.KB899548_gene93	1.765e-80	276.0	COG2173@1|root,COG2173@2|Bacteria,1RBFI@1224|Proteobacteria,2UHKM@28211|Alphaproteobacteria,43YUJ@69657|Hyphomonadaceae	28211|Alphaproteobacteria	M	D-ala-D-ala dipeptidase	ddpX	-	3.4.13.22	ko:K08641	ko01502,ko02020,map01502,map02020	M00651	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504	-	-	-	Peptidase_M15
SHD2_k127_3270096_23	1123366.TH3_14759	9.189e-101	356.0	COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,2TRTY@28211|Alphaproteobacteria,2JQU2@204441|Rhodospirillales	204441|Rhodospirillales	T	CHASE2	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc
SHD2_k127_3270096_9	1333998.M2A_2408	1.627e-179	569.0	COG1633@1|root,COG1633@2|Bacteria	2|Bacteria	S	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)	vioB	-	1.14.19.11,1.14.19.2,1.14.19.26,1.16.3.1	ko:K03594,ko:K03921,ko:K20087	ko00061,ko00404,ko00860,ko01040,ko01130,ko01212,ko02024,map00061,map00404,map00860,map01040,map01130,map01212,map02024	M00808	R00078,R03370,R08161,R11108,R11109,R11131	RC00917,RC02758,RC03364	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ferritin-like
SHD2_k127_3270096_50	1333998.M2A_0050	9.792e-43	164.0	COG1309@1|root,COG1309@2|Bacteria,1PE94@1224|Proteobacteria,2UK8Y@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
SHD2_k127_3270096_35	859657.RPSI07_mp1584	1.007e-70	247.0	COG0300@1|root,COG0300@2|Bacteria,1MWNZ@1224|Proteobacteria,2VJFQ@28216|Betaproteobacteria,1K4CZ@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	ko:K07124	-	-	-	-	ko00000	-	-	-	adh_short
SHD2_k127_3270096_22	402881.Plav_1123	7.759e-101	345.0	COG1024@1|root,COG1024@2|Bacteria,1NJ9M@1224|Proteobacteria,2U07X@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Enoyl-CoA hydratase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
SHD2_k127_3270096_67	1161401.ASJA01000002_gene2570	8.629e-17	85.0	2E8W9@1|root,3336G@2|Bacteria,1N7PH@1224|Proteobacteria,2UI6X@28211|Alphaproteobacteria,43YN3@69657|Hyphomonadaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_3270096_16	1282876.BAOK01000002_gene332	2.098e-125	415.0	COG2133@1|root,COG2133@2|Bacteria,1MVK5@1224|Proteobacteria,2TRN9@28211|Alphaproteobacteria,4BQIN@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
SHD2_k127_3270096_36	1280949.HAD_17087	2.263e-66	238.0	COG5031@1|root,COG5031@2|Bacteria,1Q8HN@1224|Proteobacteria,2V7A6@28211|Alphaproteobacteria,43ZFC@69657|Hyphomonadaceae	28211|Alphaproteobacteria	H	Coenzyme Q (ubiquinone) biosynthesis protein Coq4	-	-	-	-	-	-	-	-	-	-	-	-	Coq4
SHD2_k127_3270096_63	1397666.RS24_01489	4.592e-20	94.0	COG0762@1|root,COG0762@2|Bacteria,1N73Q@1224|Proteobacteria,2UFZR@28211|Alphaproteobacteria,4BQSA@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	YGGT family	MA20_25225	-	-	ko:K02221	-	-	-	-	ko00000,ko02044	-	-	-	YGGT
SHD2_k127_3270096_66	1292034.OR37_01321	6.707e-18	94.0	COG1872@1|root,COG1872@2|Bacteria,1N6V2@1224|Proteobacteria,2UF67@28211|Alphaproteobacteria,2KH69@204458|Caulobacterales	204458|Caulobacterales	S	Belongs to the UPF0235 family	-	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
SHD2_k127_3270096_21	1333998.M2A_0705	2.512e-105	349.0	COG0190@1|root,COG0190@2|Bacteria,1MWU4@1224|Proteobacteria,2TRZZ@28211|Alphaproteobacteria,4BP7E@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	-	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
SHD2_k127_3270096_45	1380394.JADL01000002_gene1540	3.149e-46	174.0	COG1999@1|root,COG1999@2|Bacteria,1RHJ8@1224|Proteobacteria,2U0Q3@28211|Alphaproteobacteria,2JSPF@204441|Rhodospirillales	204441|Rhodospirillales	S	protein SCO1 SenC PrrC, involved in biogenesis of respiratory and photosynthetic systems	-	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	SCO1-SenC
SHD2_k127_3270096_15	402881.Plav_0017	6.001e-127	421.0	COG4191@1|root,COG4191@2|Bacteria,1MWR3@1224|Proteobacteria,2TSS0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Histidine kinase	regB	-	2.7.13.3	ko:K15011	ko02020,map02020	M00523	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA
SHD2_k127_3270096_25	1038862.KB893917_gene4447	5.231e-88	297.0	COG1011@1|root,COG1011@2|Bacteria,1PUN6@1224|Proteobacteria,2TY0G@28211|Alphaproteobacteria,3JU2Z@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	HAD-hyrolase-like	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
SHD2_k127_3270096_31	1123059.KB823011_gene1923	6.205e-78	265.0	COG4567@1|root,COG4567@2|Bacteria,1RD7J@1224|Proteobacteria,2TSK7@28211|Alphaproteobacteria,43WQ4@69657|Hyphomonadaceae	28211|Alphaproteobacteria	KT	COG4567 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain	regA	GO:0000156,GO:0000160,GO:0003674,GO:0007154,GO:0007165,GO:0008150,GO:0009987,GO:0023052,GO:0035556,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060089,GO:0065007	-	ko:K15012	ko02020,map02020	M00523	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg
SHD2_k127_3270096_62	391600.ABRU01000050_gene60	3.855e-23	104.0	COG3801@1|root,COG3801@2|Bacteria,1RHVH@1224|Proteobacteria,2U8M4@28211|Alphaproteobacteria,2KH8A@204458|Caulobacterales	204458|Caulobacterales	S	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	-	-	-	-	-	-	-	-	-	-	-	-	YjbR
SHD2_k127_3270096_53	1161401.ASJA01000020_gene616	8.253e-38	147.0	COG5321@1|root,COG5321@2|Bacteria,1RDXW@1224|Proteobacteria,2U73Y@28211|Alphaproteobacteria,43Y8R@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	DNA repair protein MmcB-like	MA20_23405	-	-	-	-	-	-	-	-	-	-	-	MmcB-like
SHD2_k127_3270096_42	1410620.SHLA_40c000010	8.342e-54	192.0	COG1846@1|root,COG1846@2|Bacteria,1N7G0@1224|Proteobacteria,2UA2S@28211|Alphaproteobacteria,4BETA@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
SHD2_k127_3270096_75	1463917.JODC01000003_gene5826	1.148e-05	53.0	COG3795@1|root,COG3795@2|Bacteria,2IHYC@201174|Actinobacteria	201174|Actinobacteria	S	PFAM YCII-related	-	-	-	-	-	-	-	-	-	-	-	-	YCII
SHD2_k127_3270096_41	106370.Francci3_2914	4.184e-57	209.0	COG3865@1|root,COG3865@2|Bacteria,2IIAX@201174|Actinobacteria,4ESIH@85013|Frankiales	201174|Actinobacteria	S	3-demethylubiquinone-9 3-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	3-dmu-9_3-mt
SHD2_k127_3270096_10	1333998.M2A_0365	1.76e-173	551.0	COG1633@1|root,COG1633@2|Bacteria,1R02H@1224|Proteobacteria,2TYHQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	P-aminobenzoate N-oxygenase AurF	-	-	-	-	-	-	-	-	-	-	-	-	AurF
SHD2_k127_3270096_24	402881.Plav_1237	9.406e-93	309.0	COG0131@1|root,COG0131@2|Bacteria,1MWBS@1224|Proteobacteria,2TTVV@28211|Alphaproteobacteria,1JNR8@119043|Rhodobiaceae	28211|Alphaproteobacteria	E	Imidazoleglycerol-phosphate dehydratase	hisB	GO:0000105,GO:0003674,GO:0003824,GO:0004424,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.6.1.9,3.1.3.15,4.2.1.19	ko:K00817,ko:K01089,ko:K01693	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03013,R03243,R03457	RC00006,RC00017,RC00888,RC00932	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	IGPD
SHD2_k127_3270096_61	1225785.CM001983_gene2435	1.083e-23	112.0	COG2503@1|root,COG2503@2|Bacteria,1RB4N@1224|Proteobacteria,1RY2I@1236|Gammaproteobacteria,2JC50@204037|Dickeya	1236|Gammaproteobacteria	M	PFAM acid phosphatase (Class B)	hel	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Acid_phosphat_B
SHD2_k127_3270096_32	244582.JQAK01000001_gene2001	1.39e-77	265.0	COG5405@1|root,COG5405@2|Bacteria,1MVF2@1224|Proteobacteria,2TRRE@28211|Alphaproteobacteria,47F57@766|Rickettsiales	766|Rickettsiales	O	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery	hslV	-	3.4.25.2	ko:K01419	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Proteasome
SHD2_k127_3270096_8	1282876.BAOK01000002_gene162	1.479e-203	640.0	COG1220@1|root,COG1220@2|Bacteria,1MVK9@1224|Proteobacteria,2TRXC@28211|Alphaproteobacteria,4BREN@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	O	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis	hslU	-	-	ko:K03667	-	-	-	-	ko00000,ko03110	-	-	-	AAA_2,ClpB_D2-small
SHD2_k127_3270096_56	306281.AJLK01000105_gene3517	8.439e-35	138.0	COG3791@1|root,COG3791@2|Bacteria,1GAQM@1117|Cyanobacteria,1JKVU@1189|Stigonemataceae	1117|Cyanobacteria	S	Glutathione-dependent formaldehyde-activating enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GFA
SHD2_k127_3270096_7	639283.Snov_3955	1.53e-211	663.0	COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,2TR4P@28211|Alphaproteobacteria,3EYF2@335928|Xanthobacteraceae	28211|Alphaproteobacteria	H	S-adenosylmethionine synthetase, C-terminal domain	metK	GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
SHD2_k127_3270096_28	443598.AUFA01000019_gene2904	1.69e-82	282.0	COG0730@1|root,COG0730@2|Bacteria,1RCVI@1224|Proteobacteria,2U5XM@28211|Alphaproteobacteria,3JQXX@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Sulfite exporter TauE/SafE	MA20_18170	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
SHD2_k127_3270096_34	1121033.AUCF01000003_gene3298	1.409e-71	248.0	COG0220@1|root,COG0220@2|Bacteria,1MUWJ@1224|Proteobacteria,2TUU9@28211|Alphaproteobacteria,2JRSC@204441|Rhodospirillales	204441|Rhodospirillales	J	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA	trmB	-	2.1.1.33	ko:K03439	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_4
SHD2_k127_3270096_44	314260.PB2503_04292	3.029e-49	183.0	COG0779@1|root,COG0779@2|Bacteria,1RDP2@1224|Proteobacteria,2TS4E@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Required for maturation of 30S ribosomal subunits	rimP	GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576	-	ko:K09748	-	-	-	-	ko00000,ko03009	-	-	-	DUF150,DUF150_C
SHD2_k127_3270096_6	1333998.M2A_0313	2.324e-237	744.0	COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,2TRQN@28211|Alphaproteobacteria,4BPK3@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	HHH_5,KH_5,NusA_N,S1
SHD2_k127_3270096_46	1449049.JONW01000006_gene2674	8.217e-45	176.0	COG2740@1|root,COG2740@2|Bacteria,1RHPR@1224|Proteobacteria,2U9RY@28211|Alphaproteobacteria,2KGI2@204458|Caulobacterales	204458|Caulobacterales	K	Protein of unknown function (DUF448)	-	-	-	ko:K07742	-	-	-	-	ko00000	-	-	-	DUF448,Ribosomal_L7Ae
SHD2_k127_3270096_3	402881.Plav_3628	3.397e-293	925.0	COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,2TQMY@28211|Alphaproteobacteria,1JN5S@119043|Rhodobiaceae	28211|Alphaproteobacteria	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N,IF2_assoc
SHD2_k127_3270096_52	1298867.AUES01000009_gene5929	3.857e-39	150.0	COG0858@1|root,COG0858@2|Bacteria,1MZPE@1224|Proteobacteria,2UCJF@28211|Alphaproteobacteria,3JY9A@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
SHD2_k127_3270096_18	1380391.JIAS01000018_gene934	1.325e-113	377.0	COG0130@1|root,COG0130@2|Bacteria,1MV0N@1224|Proteobacteria,2TSJK@28211|Alphaproteobacteria,2JQHY@204441|Rhodospirillales	204441|Rhodospirillales	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	-	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB-C_2,TruB_C_2,TruB_N
SHD2_k127_3270096_54	1082931.KKY_3447	1.185e-35	138.0	COG0184@1|root,COG0184@2|Bacteria,1MZ2W@1224|Proteobacteria,2UBRZ@28211|Alphaproteobacteria,3N735@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
SHD2_k127_3270096_1	911045.PSE_0514	5e-324	1005.0	COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,2TRH3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0019222,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0140098,GO:1901360,GO:1901361,GO:1901363,GO:1901575	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
SHD2_k127_3270096_30	1380394.JADL01000003_gene5217	5.699e-79	269.0	COG2096@1|root,COG2096@2|Bacteria,1RDUF@1224|Proteobacteria,2U5J1@28211|Alphaproteobacteria,2JRV2@204441|Rhodospirillales	204441|Rhodospirillales	S	Cobalamin adenosyltransferase	-	-	2.5.1.17	ko:K00798	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	Cob_adeno_trans
SHD2_k127_3270096_64	1479238.JQMZ01000001_gene304	7.561e-19	89.0	COG4391@1|root,COG4391@2|Bacteria,1N7F4@1224|Proteobacteria,2UFVF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	zf-CHCC
SHD2_k127_3270096_0	639283.Snov_3875	0.0	1143.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,2TRJF@28211|Alphaproteobacteria,3EZ5J@335928|Xanthobacteraceae	28211|Alphaproteobacteria	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
SHD2_k127_3270096_65	1110502.TMO_2890	7.696e-19	93.0	COG0597@1|root,COG0597@2|Bacteria,1RGV9@1224|Proteobacteria,2UBUC@28211|Alphaproteobacteria,2JTBQ@204441|Rhodospirillales	204441|Rhodospirillales	MU	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	lspA	-	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
SHD2_k127_3270096_57	234267.Acid_4769	7.962e-30	122.0	29WUP@1|root,30IG4@2|Bacteria,3Y82K@57723|Acidobacteria	57723|Acidobacteria	S	ASCH	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_3270096_27	394221.Mmar10_0073	5.297e-85	303.0	28IA1@1|root,2Z8CN@2|Bacteria,1QTRI@1224|Proteobacteria,2U31S@28211|Alphaproteobacteria,43XU5@69657|Hyphomonadaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_3270096_20	269796.Rru_A3793	2.669e-107	353.0	COG0476@1|root,COG0476@2|Bacteria,1MW7H@1224|Proteobacteria,2TRWY@28211|Alphaproteobacteria,2JQG1@204441|Rhodospirillales	204441|Rhodospirillales	H	COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2	moeB	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF
SHD2_k127_3270096_5	402881.Plav_0109	6.852e-262	816.0	COG1866@1|root,COG1866@2|Bacteria,1MWXN@1224|Proteobacteria,2TRC4@28211|Alphaproteobacteria,1JNE6@119043|Rhodobiaceae	28211|Alphaproteobacteria	C	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA	pckA	GO:0003674,GO:0003824,GO:0004611,GO:0004612,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0008150,GO:0008152,GO:0009058,GO:0016051,GO:0016829,GO:0016830,GO:0016831,GO:0019318,GO:0019319,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0071704,GO:1901576	4.1.1.49	ko:K01610	ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00170	R00341	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_ATP
SHD2_k127_3270096_49	69279.BG36_23125	4.971e-43	166.0	COG3963@1|root,COG3963@2|Bacteria,1N1KB@1224|Proteobacteria,2TVD9@28211|Alphaproteobacteria,43I6Z@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	I	ribosomal RNA adenine methylase transferase	pmtA	-	2.1.1.17,2.1.1.71	ko:K00570	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00091	R01320,R02056,R03424	RC00003,RC00060,RC00181,RC00496	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_25,RrnaAD
SHD2_k127_3270096_11	388739.RSK20926_08247	4.212e-159	510.0	COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,2TRZ1@28211|Alphaproteobacteria,2P23T@2433|Roseobacter	28211|Alphaproteobacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
SHD2_k127_3270096_2	1122963.AUHB01000002_gene880	9.544e-314	970.0	COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,2TR5H@28211|Alphaproteobacteria,36XPS@31993|Methylocystaceae	28211|Alphaproteobacteria	O	MreB/Mbl protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
SHD2_k127_3270096_14	1380391.JIAS01000011_gene5391	1.632e-142	458.0	COG0624@1|root,COG0624@2|Bacteria,1MW20@1224|Proteobacteria,2TQY4@28211|Alphaproteobacteria,2JVFA@204441|Rhodospirillales	204441|Rhodospirillales	E	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
SHD2_k127_3298042_93	395964.KE386496_gene323	1.783e-38	157.0	COG0664@1|root,COG0664@2|Bacteria,1NEQM@1224|Proteobacteria,2U1CS@28211|Alphaproteobacteria,3NBI4@45404|Beijerinckiaceae	28211|Alphaproteobacteria	K	Crp-like helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
SHD2_k127_3298042_115	342113.DM82_3233	3.844e-13	82.0	COG3038@1|root,COG3038@2|Bacteria,1REWF@1224|Proteobacteria,2VRCI@28216|Betaproteobacteria,1K6PD@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Cytochrome B561	-	-	-	ko:K12262	-	-	-	-	ko00000	-	-	-	Ni_hydr_CYTB
SHD2_k127_3298042_113	114615.BRADO0675	3.201e-14	76.0	COG3794@1|root,COG3794@2|Bacteria,1RE6B@1224|Proteobacteria,2UAER@28211|Alphaproteobacteria,3JZ39@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cupredoxin_1
SHD2_k127_3298042_37	1144310.PMI07_005955	9.634e-111	369.0	COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,2TRTJ@28211|Alphaproteobacteria,4B8DR@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	cytochrome c peroxidase	-	GO:0005575,GO:0005623,GO:0042597,GO:0044464	1.11.1.5	ko:K00428	-	-	-	-	ko00000,ko01000	-	-	-	CCP_MauG,Cytochrom_C
SHD2_k127_3298042_119	1219035.NT2_10_00830	7.869e-05	51.0	2DFQQ@1|root,2ZSPR@2|Bacteria,1NJDZ@1224|Proteobacteria,2UMRP@28211|Alphaproteobacteria,2K6BK@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_3298042_22	1282876.BAOK01000001_gene3274	3.694e-143	467.0	COG0717@1|root,COG0717@2|Bacteria,1MVDH@1224|Proteobacteria,2TR5U@28211|Alphaproteobacteria,4BPQW@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	F	2'-deoxycytidine 5'-triphosphate deaminase (DCD)	dcd	-	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	DCD
SHD2_k127_3298042_87	332101.JIBU02000027_gene2778	1.212e-44	181.0	COG0793@1|root,COG0793@2|Bacteria,1UYV5@1239|Firmicutes,24B0A@186801|Clostridia,36DRS@31979|Clostridiaceae	186801|Clostridia	M	Peptidase, S41	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S41
SHD2_k127_3298042_2	402881.Plav_0430	6.447e-288	910.0	COG1199@1|root,COG1199@2|Bacteria,1MVCU@1224|Proteobacteria,2TUKS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	KL	helicase	dinG	-	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Helicase_C_2
SHD2_k127_3298042_9	1121949.AQXT01000002_gene1668	4.861e-216	682.0	COG1384@1|root,COG1384@2|Bacteria,1MV32@1224|Proteobacteria,2TQYH@28211|Alphaproteobacteria,43WXV@69657|Hyphomonadaceae	28211|Alphaproteobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04566	ko00970,map00970	M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1f
SHD2_k127_3298042_54	639283.Snov_0062	5.136e-84	284.0	COG2932@1|root,COG2932@2|Bacteria,1MXWS@1224|Proteobacteria,2TQJE@28211|Alphaproteobacteria,3EZ19@335928|Xanthobacteraceae	28211|Alphaproteobacteria	K	Peptidase S24-like	c1	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S24
SHD2_k127_3298042_29	1244869.H261_16084	2.16e-120	397.0	COG0167@1|root,COG0167@2|Bacteria,1MU7C@1224|Proteobacteria,2TRF8@28211|Alphaproteobacteria,2JPD2@204441|Rhodospirillales	204441|Rhodospirillales	F	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor	pyrD	-	1.3.5.2	ko:K00254	ko00240,ko01100,map00240,map01100	M00051	R01868	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
SHD2_k127_3298042_89	1333998.M2A_2074	4.093e-43	161.0	COG2050@1|root,COG2050@2|Bacteria,1RITB@1224|Proteobacteria,2U58S@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	protein possibly involved in aromatic compounds catabolism	-	-	-	-	-	-	-	-	-	-	-	-	4HBT,4HBT_3
SHD2_k127_3298042_100	402881.Plav_0441	9.203e-29	124.0	COG2050@1|root,COG2050@2|Bacteria,1RHK6@1224|Proteobacteria,2U72Z@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	protein, possibly involved in aromatic compounds catabolism	MA20_04725	-	-	-	-	-	-	-	-	-	-	-	4HBT
SHD2_k127_3298042_72	402881.Plav_0444	7.095e-66	231.0	COG1309@1|root,COG1309@2|Bacteria,1PFTR@1224|Proteobacteria,2VCUA@28211|Alphaproteobacteria,1JQFE@119043|Rhodobiaceae	28211|Alphaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
SHD2_k127_3298042_33	402881.Plav_0449	1.762e-116	384.0	COG0604@1|root,COG0604@2|Bacteria,1MWRK@1224|Proteobacteria,2TQMF@28211|Alphaproteobacteria,1JNWZ@119043|Rhodobiaceae	28211|Alphaproteobacteria	C	PFAM Alcohol dehydrogenase zinc-binding domain protein	MA20_32380	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
SHD2_k127_3298042_18	419610.Mext_2524	1.759e-153	492.0	COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,2TQKG@28211|Alphaproteobacteria,1JRE3@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
SHD2_k127_3298042_64	1282876.BAOK01000001_gene1688	8.085e-76	262.0	COG1024@1|root,COG1024@2|Bacteria,1R623@1224|Proteobacteria,2U5F0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	enoyl-CoA hydratase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
SHD2_k127_3298042_44	1528106.JRJE01000006_gene1085	2.943e-102	336.0	COG0066@1|root,COG0066@2|Bacteria,1MVXB@1224|Proteobacteria,2TRRS@28211|Alphaproteobacteria,2JPTP@204441|Rhodospirillales	204441|Rhodospirillales	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
SHD2_k127_3298042_59	1382303.JPOM01000001_gene392	5.531e-80	277.0	COG0395@1|root,COG0395@2|Bacteria,1REG1@1224|Proteobacteria,2U2QS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Inward rectifier potassium channel	-	-	-	ko:K08715	-	-	-	-	ko00000,ko02000	1.A.2.2	-	-	IRK
SHD2_k127_3298042_91	414684.RC1_2501	5.19e-41	157.0	COG3536@1|root,COG3536@2|Bacteria,1MZ5M@1224|Proteobacteria,2U9GJ@28211|Alphaproteobacteria,2JT01@204441|Rhodospirillales	204441|Rhodospirillales	S	Protein of unknown function (DUF971)	-	-	-	-	-	-	-	-	-	-	-	-	DUF971
SHD2_k127_3298042_106	1161401.ASJA01000002_gene2738	1.436e-20	92.0	COG2835@1|root,COG2835@2|Bacteria,1N6Y2@1224|Proteobacteria,2UF4N@28211|Alphaproteobacteria,43YFF@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	Belongs to the UPF0434 family	MA20_24965	-	-	ko:K09791	-	-	-	-	ko00000	-	-	-	Trm112p
SHD2_k127_3298042_71	1333998.M2A_0161	8.113e-67	233.0	COG2802@1|root,COG2802@2|Bacteria,1NV9N@1224|Proteobacteria,2TQZ4@28211|Alphaproteobacteria,4BQB8@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	ATP-dependent protease La (LON) substrate-binding domain	lonD	-	3.4.21.53	ko:K01338,ko:K07157	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	LON_substr_bdg
SHD2_k127_3298042_41	402881.Plav_1312	4.024e-104	348.0	COG3118@1|root,COG3118@2|Bacteria,1MV0R@1224|Proteobacteria,2TS5X@28211|Alphaproteobacteria,1JNMU@119043|Rhodobiaceae	28211|Alphaproteobacteria	O	Tetratricopeptide repeat	trxA2	-	-	ko:K03671,ko:K05838	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	TPR_19,TPR_20,Thioredoxin
SHD2_k127_3298042_108	882.DVU_2619	1.759e-19	100.0	COG0726@1|root,COG0726@2|Bacteria,1MY9E@1224|Proteobacteria,42SIV@68525|delta/epsilon subdivisions,2X6KV@28221|Deltaproteobacteria,2MH4A@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	Protein of unknown function (DUF3298)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3298,DUF4163
SHD2_k127_3298042_120	1150469.RSPPHO_02025	0.0001392	53.0	COG4461@1|root,COG4461@2|Bacteria,1R0Z2@1224|Proteobacteria,2TYV9@28211|Alphaproteobacteria,2JUJW@204441|Rhodospirillales	204441|Rhodospirillales	S	Lysozyme inhibitor LprI	-	-	-	-	-	-	-	-	-	-	-	-	LprI
SHD2_k127_3298042_65	1038860.AXAP01000012_gene1234	3.968e-75	273.0	COG1231@1|root,COG1231@2|Bacteria,1R5ZI@1224|Proteobacteria	1224|Proteobacteria	E	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
SHD2_k127_3298042_86	402881.Plav_1090	2.187e-46	174.0	COG1670@1|root,COG1670@2|Bacteria,1MXEE@1224|Proteobacteria,2U62V@28211|Alphaproteobacteria,1JP4C@119043|Rhodobiaceae	28211|Alphaproteobacteria	J	Acetyltransferase (GNAT) domain	-	-	-	ko:K22479	-	-	-	-	ko00000	-	-	-	Acetyltransf_3
SHD2_k127_3298042_83	1528106.JRJE01000032_gene3063	6.395e-48	177.0	COG3760@1|root,COG3760@2|Bacteria,1RDIG@1224|Proteobacteria,2U87T@28211|Alphaproteobacteria,2JSRQ@204441|Rhodospirillales	204441|Rhodospirillales	S	Aminoacyl-tRNA editing domain	-	-	-	ko:K19055	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_edit
SHD2_k127_3298042_46	1238182.C882_2855	1.034e-95	321.0	COG0421@1|root,COG0421@2|Bacteria,1MVV5@1224|Proteobacteria,2TQZ3@28211|Alphaproteobacteria,2JRG9@204441|Rhodospirillales	204441|Rhodospirillales	E	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	speE	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synt_N,Spermine_synth
SHD2_k127_3298042_82	1150469.RSPPHO_01208	1.859e-51	186.0	COG1586@1|root,COG1586@2|Bacteria,1RH88@1224|Proteobacteria,2U5D3@28211|Alphaproteobacteria,2JT4E@204441|Rhodospirillales	204441|Rhodospirillales	H	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine	speH	-	4.1.1.50	ko:K01611	ko00270,ko00330,ko01100,map00270,map00330,map01100	M00034,M00133	R00178	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	AdoMet_dc
SHD2_k127_3298042_112	1449049.JONW01000006_gene2704	1.742e-15	80.0	2C4HP@1|root,33HN5@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_3298042_76	1121124.JNIX01000008_gene2512	7.324e-58	207.0	COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,2U5A1@28211|Alphaproteobacteria,2KGEK@204458|Caulobacterales	204458|Caulobacterales	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
SHD2_k127_3298042_35	1207063.P24_08629	3.373e-111	370.0	COG0687@1|root,COG0687@2|Bacteria,1MUYW@1224|Proteobacteria,2TS7M@28211|Alphaproteobacteria,2JWCN@204441|Rhodospirillales	204441|Rhodospirillales	E	Bacterial extracellular solute-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_8
SHD2_k127_3298042_20	402881.Plav_0955	2.213e-146	477.0	COG0174@1|root,COG0174@2|Bacteria,1MU6V@1224|Proteobacteria,2TTPD@28211|Alphaproteobacteria,1JNAJ@119043|Rhodobiaceae	28211|Alphaproteobacteria	E	Glutamine synthetase, catalytic domain	glnA	GO:0003674,GO:0003824,GO:0006576,GO:0006595,GO:0006598,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009308,GO:0009310,GO:0009445,GO:0009447,GO:0009987,GO:0016874,GO:0016879,GO:0016880,GO:0034024,GO:0034641,GO:0042402,GO:0044106,GO:0044237,GO:0071704,GO:0097164,GO:1901564,GO:1901565,GO:1901575	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C
SHD2_k127_3298042_88	1040983.AXAE01000016_gene1050	9.886e-44	178.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2TRHH@28211|Alphaproteobacteria,43GX9@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	T	Histidine kinase	pleC	-	2.7.13.3	ko:K07716	ko02020,ko04112,map02020,map04112	M00511	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_7
SHD2_k127_3298042_1	402881.Plav_0957	2.891e-297	936.0	COG0308@1|root,COG0308@2|Bacteria,1MUCI@1224|Proteobacteria,2TRUM@28211|Alphaproteobacteria,1JN2F@119043|Rhodobiaceae	28211|Alphaproteobacteria	E	Domain of unknown function (DUF3458_C) ARM repeats	pepN	GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0008270,GO:0016020,GO:0016787,GO:0019538,GO:0033218,GO:0042277,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0070006,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564	3.4.11.2	ko:K01256	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3458,DUF3458_C,Peptidase_M1
SHD2_k127_3298042_74	1123503.KB908058_gene966	7.17e-62	217.0	294IW@1|root,2ZRYG@2|Bacteria,1RF2C@1224|Proteobacteria,2U789@28211|Alphaproteobacteria,2KGGU@204458|Caulobacterales	204458|Caulobacterales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_3298042_21	316058.RPB_1687	7.242e-144	465.0	COG1960@1|root,COG1960@2|Bacteria,1N05C@1224|Proteobacteria,2TT9T@28211|Alphaproteobacteria,3JTG7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	acyl-CoA dehydrogenase	MA20_06725	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_N
SHD2_k127_3298042_15	402881.Plav_0965	1.178e-168	545.0	COG1960@1|root,COG1960@2|Bacteria,1MVJC@1224|Proteobacteria,2TTRD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
SHD2_k127_3298042_95	1282876.BAOK01000001_gene3207	5.808e-38	153.0	COG0346@1|root,COG0346@2|Bacteria,1N1D4@1224|Proteobacteria,2UBYV@28211|Alphaproteobacteria,4BTBY@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
SHD2_k127_3298042_110	316058.RPB_3396	6.976e-16	79.0	COG3313@1|root,COG3313@2|Bacteria,1NGD5@1224|Proteobacteria,2UJKX@28211|Alphaproteobacteria,3K12V@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1289)	-	-	-	ko:K06938	-	-	-	-	ko00000	-	-	-	DUF1289
SHD2_k127_3298042_45	402881.Plav_1055	2.321e-97	326.0	COG0007@1|root,COG0007@2|Bacteria,1MUI0@1224|Proteobacteria,2TRJC@28211|Alphaproteobacteria,1JNJ6@119043|Rhodobiaceae	28211|Alphaproteobacteria	H	Tetrapyrrole (Corrin/Porphyrin) Methylases	cobA	-	1.3.1.76,2.1.1.107,4.99.1.4	ko:K02302,ko:K02303	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03194,R03947	RC00003,RC00871,RC01012,RC01034	ko00000,ko00001,ko00002,ko01000	-	-	-	CysG_dimeriser,NAD_binding_7,Sirohm_synth_M,TP_methylase
SHD2_k127_3298042_7	402881.Plav_1053	3.889e-242	758.0	COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,2TRIJ@28211|Alphaproteobacteria,1JN8J@119043|Rhodobiaceae	28211|Alphaproteobacteria	G	Phosphoglucomutase/phosphomannomutase, C-terminal domain	algC	-	5.4.2.2,5.4.2.8	ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
SHD2_k127_3298042_52	1333998.M2A_1696	2.962e-86	295.0	COG0730@1|root,COG0730@2|Bacteria,1R3V4@1224|Proteobacteria,2TRYX@28211|Alphaproteobacteria,4BQAF@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
SHD2_k127_3298042_42	450851.PHZ_c2446	4.128e-104	349.0	COG0657@1|root,COG0657@2|Bacteria,1N5QB@1224|Proteobacteria,2U1WU@28211|Alphaproteobacteria,2KG03@204458|Caulobacterales	204458|Caulobacterales	I	Esterase lipase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3,Peptidase_S9
SHD2_k127_3298042_26	450851.PHZ_c2343	1.12e-131	427.0	COG0042@1|root,COG0042@2|Bacteria,1MUY1@1224|Proteobacteria,2TSRR@28211|Alphaproteobacteria,2KEXC@204458|Caulobacterales	204458|Caulobacterales	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs	dusA	-	-	ko:K05539	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
SHD2_k127_3298042_4	59538.XP_005979433.1	2.622e-264	822.0	COG1233@1|root,KOG4254@2759|Eukaryota,38CXC@33154|Opisthokonta,3BDJK@33208|Metazoa,3CVDZ@33213|Bilateria,4861H@7711|Chordata,494P3@7742|Vertebrata,3J26K@40674|Mammalia,4IZNT@91561|Cetartiodactyla	59538.XP_005979433.1|-	H	Pyridine nucleotide-disulfide oxidoreductase domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_3298042_51	1532558.JL39_08595	2.886e-88	292.0	COG3558@1|root,COG3558@2|Bacteria,1RA64@1224|Proteobacteria,2U5FW@28211|Alphaproteobacteria,4BA8V@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1348)	-	-	-	ko:K09958	-	-	-	-	ko00000	-	-	-	DUF1348
SHD2_k127_3298042_67	1112212.JH584235_gene1040	2.72e-72	250.0	COG3576@1|root,COG3576@2|Bacteria,1NBWC@1224|Proteobacteria,2TUCA@28211|Alphaproteobacteria,2K3ZV@204457|Sphingomonadales	204457|Sphingomonadales	S	Pyridoxamine 5'-phosphate	-	-	-	ko:K07006	-	-	-	-	ko00000	-	-	-	Putative_PNPOx
SHD2_k127_3298042_68	670292.JH26_10505	3.263e-72	250.0	COG2128@1|root,COG2128@2|Bacteria,1NXI8@1224|Proteobacteria,2VF1Y@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
SHD2_k127_3298042_32	1169143.KB911035_gene1977	4.005e-117	384.0	COG0583@1|root,COG0583@2|Bacteria,1MUNN@1224|Proteobacteria,2VKER@28216|Betaproteobacteria,1K138@119060|Burkholderiaceae	28216|Betaproteobacteria	K	LysR family transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
SHD2_k127_3298042_47	1280952.HJA_05127	5.243e-94	315.0	COG1028@1|root,COG1028@2|Bacteria,1MUFX@1224|Proteobacteria,2TRWN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
SHD2_k127_3298042_56	450851.PHZ_c2843	9.655e-83	278.0	COG2128@1|root,COG2128@2|Bacteria,1MVWP@1224|Proteobacteria,2VGCN@28211|Alphaproteobacteria,2KIKP@204458|Caulobacterales	204458|Caulobacterales	S	Carboxymuconolactone decarboxylase family	-	-	-	-	-	-	-	-	-	-	-	-	CMD
SHD2_k127_3298042_14	247633.GP2143_18046	2.742e-175	559.0	COG2159@1|root,COG2159@2|Bacteria,1MVTS@1224|Proteobacteria,1T0VR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
SHD2_k127_3298042_73	1282362.AEAC466_01450	1.865e-64	232.0	COG3577@1|root,COG3577@2|Bacteria,1MYAD@1224|Proteobacteria,2UDTN@28211|Alphaproteobacteria,2KH1B@204458|Caulobacterales	204458|Caulobacterales	S	gag-polyprotein putative aspartyl protease	-	-	-	-	-	-	-	-	-	-	-	-	Asp_protease_2
SHD2_k127_3298042_49	1280954.HPO_07187	7.741e-91	310.0	COG0667@1|root,COG0667@2|Bacteria,1MWGQ@1224|Proteobacteria,2TUJ8@28211|Alphaproteobacteria,43XEC@69657|Hyphomonadaceae	28211|Alphaproteobacteria	C	Aldo/keto reductase family	pld	-	1.1.1.122	ko:K00064	ko00051,ko00053,ko01100,ko01110,ko01120,map00051,map00053,map01100,map01110,map01120	M00114	R07675,R08926	RC00066,RC00161	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldo_ket_red
SHD2_k127_3298042_57	1207063.P24_08334	1.6e-81	284.0	COG1028@1|root,COG1028@2|Bacteria,1MURZ@1224|Proteobacteria,2TQJ6@28211|Alphaproteobacteria,2JR9E@204441|Rhodospirillales	204441|Rhodospirillales	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	ko:K18335	ko00051,ko01120,map00051,map01120	-	R10690	RC00089	ko00000,ko00001,ko01000	-	-	-	adh_short_C2
SHD2_k127_3298042_23	483219.LILAB_08310	8.097e-140	450.0	COG3491@1|root,COG3491@2|Bacteria,1MUNT@1224|Proteobacteria,42UZV@68525|delta/epsilon subdivisions,2X5RT@28221|Deltaproteobacteria,2YUED@29|Myxococcales	28221|Deltaproteobacteria	C	Belongs to the iron ascorbate-dependent oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	2OG-FeII_Oxy,DIOX_N
SHD2_k127_3298042_13	402881.Plav_0369	1.629e-180	572.0	COG0654@1|root,COG0654@2|Bacteria,1R7NX@1224|Proteobacteria	1224|Proteobacteria	CH	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
SHD2_k127_3298042_84	1280949.HAD_15577	2.938e-47	175.0	COG4319@1|root,COG4319@2|Bacteria,1NHKV@1224|Proteobacteria,2UTI1@28211|Alphaproteobacteria,43ZYY@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
SHD2_k127_3298042_40	402881.Plav_0367	9.498e-106	356.0	COG3173@1|root,COG3173@2|Bacteria,1R7XK@1224|Proteobacteria,2TTWB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Aminoglycoside phosphotransferase	-	-	-	-	-	-	-	-	-	-	-	-	APH,EcKinase
SHD2_k127_3298042_111	402881.Plav_3648	8.313e-16	79.0	COG0300@1|root,COG0300@2|Bacteria,1R409@1224|Proteobacteria,2TRST@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
SHD2_k127_3298042_102	1040989.AWZU01000011_gene4033	6.002e-25	109.0	2DNGD@1|root,32XCZ@2|Bacteria,1RJW1@1224|Proteobacteria,2U9RF@28211|Alphaproteobacteria,3JZJE@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_3298042_36	402881.Plav_2012	3.736e-111	362.0	COG0778@1|root,COG0778@2|Bacteria,1PG8V@1224|Proteobacteria,2U59W@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Nitroreductase	pnbA	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
SHD2_k127_3298042_6	450851.PHZ_c1807	2.726e-243	767.0	COG2072@1|root,COG2072@2|Bacteria,1MUQH@1224|Proteobacteria,2TRG4@28211|Alphaproteobacteria,2KIUB@204458|Caulobacterales	204458|Caulobacterales	C	Flavin-binding monooxygenase-like	-	-	1.14.13.84	ko:K14520	ko00363,ko01100,ko01120,map00363,map01100,map01120	-	R06892	RC01644	ko00000,ko00001,ko01000	-	-	-	-
SHD2_k127_3298042_98	69395.JQLZ01000002_gene1255	8.978e-30	122.0	COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,2TSB8@28211|Alphaproteobacteria,2KHPC@204458|Caulobacterales	204458|Caulobacterales	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
SHD2_k127_3298042_90	661478.OP10G_0182	1.665e-41	171.0	COG5285@1|root,COG5285@2|Bacteria	2|Bacteria	Q	dioxygenase activity	-	-	1.14.11.18	ko:K00477	ko04146,map04146	-	-	-	ko00000,ko00001,ko01000	-	-	-	PhyH
SHD2_k127_3298042_5	1282876.BAOK01000001_gene2666	6.158e-245	772.0	COG2730@1|root,COG2730@2|Bacteria,1R5YR@1224|Proteobacteria,2U55F@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Cellulase (glycosyl hydrolase family 5)	-	-	-	-	-	-	-	-	-	-	-	-	Cellulase
SHD2_k127_3298042_77	331869.BAL199_23427	6.19e-57	205.0	COG1280@1|root,COG1280@2|Bacteria,1R5K2@1224|Proteobacteria,2U1GA@28211|Alphaproteobacteria,4BTDJ@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	LysE type translocator	-	GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015175,GO:0015179,GO:0015318,GO:0015711,GO:0015804,GO:0015807,GO:0015849,GO:0016020,GO:0022857,GO:0034220,GO:0042968,GO:0042970,GO:0044464,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098656,GO:1902475,GO:1903825,GO:1905039	-	-	-	-	-	-	-	-	-	-	LysE
SHD2_k127_3298042_31	614083.AWQR01000014_gene2485	1.799e-118	388.0	COG1028@1|root,COG1028@2|Bacteria,1MVYJ@1224|Proteobacteria,2VMG6@28216|Betaproteobacteria,4ABN6@80864|Comamonadaceae	28216|Betaproteobacteria	IQ	PFAM Short-chain dehydrogenase reductase SDR	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
SHD2_k127_3298042_92	1116369.KB890024_gene4680	6.41e-40	151.0	COG1605@1|root,COG1605@2|Bacteria,1MZTQ@1224|Proteobacteria,2UCMC@28211|Alphaproteobacteria,43KB1@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	chorismate mutase	tyrA	-	5.4.99.5	ko:K04092	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R01715	RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	CM_2
SHD2_k127_3298042_11	1333998.M2A_1706	1.868e-186	591.0	COG1960@1|root,COG1960@2|Bacteria,1MVJC@1224|Proteobacteria,2TQRA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
SHD2_k127_3298042_16	402881.Plav_1061	1.682e-163	524.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TREJ@28211|Alphaproteobacteria,1JNM7@119043|Rhodobiaceae	28211|Alphaproteobacteria	C	PFAM acyl-CoA dehydrogenase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
SHD2_k127_3298042_103	1122604.JONR01000003_gene1497	1.256e-24	111.0	COG2863@1|root,COG2863@2|Bacteria,1RM00@1224|Proteobacteria,1SQEF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
SHD2_k127_3298042_58	492774.JQMB01000008_gene331	5.053e-81	274.0	COG0500@1|root,COG2226@2|Bacteria,1RAAZ@1224|Proteobacteria,2U5A9@28211|Alphaproteobacteria,4BNXD@82115|Rhizobiaceae	28211|Alphaproteobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
SHD2_k127_3298042_69	502025.Hoch_2745	1.201e-71	252.0	28NPB@1|root,2ZBP9@2|Bacteria,1R3HY@1224|Proteobacteria,43BB6@68525|delta/epsilon subdivisions,2X6QB@28221|Deltaproteobacteria,2YYYB@29|Myxococcales	28221|Deltaproteobacteria	S	Sulfotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_1
SHD2_k127_3298042_61	1282876.BAOK01000001_gene2515	3.135e-78	280.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2TUYS@28211|Alphaproteobacteria,4BR8U@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	T	His Kinase A (phosphoacceptor) domain	MA20_25925	-	2.7.13.3	ko:K07716	ko02020,ko04112,map02020,map04112	M00511	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA
SHD2_k127_3298042_30	402881.Plav_1063	6.332e-120	391.0	COG1024@1|root,COG1024@2|Bacteria,1MWF6@1224|Proteobacteria,2TVBC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	enoyl-CoA hydratase	-	-	5.3.3.18	ko:K15866	ko00360,ko01120,map00360,map01120	-	R09837,R09839	RC00004,RC00326,RC02689,RC03003	ko00000,ko00001,ko01000	-	-	-	ECH_1
SHD2_k127_3298042_70	1282876.BAOK01000001_gene2515	3.12e-70	256.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2TUYS@28211|Alphaproteobacteria,4BR8U@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	T	His Kinase A (phosphoacceptor) domain	MA20_25925	-	2.7.13.3	ko:K07716	ko02020,ko04112,map02020,map04112	M00511	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA
SHD2_k127_3298042_101	1280941.HY2_13780	3.087e-28	116.0	COG1359@1|root,COG1359@2|Bacteria,1N6JS@1224|Proteobacteria,2UEN1@28211|Alphaproteobacteria,43YMX@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
SHD2_k127_3298042_80	1122604.JONR01000034_gene392	8.714e-53	194.0	COG2020@1|root,COG2020@2|Bacteria,1MXP9@1224|Proteobacteria	1224|Proteobacteria	O	PFAM Isoprenylcysteine carboxyl methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	ICMT,PEMT
SHD2_k127_3298042_8	450851.PHZ_c3272	4.045e-233	731.0	COG0111@1|root,COG0111@2|Bacteria,1MU5Z@1224|Proteobacteria,2TR0F@28211|Alphaproteobacteria,2KG2A@204458|Caulobacterales	204458|Caulobacterales	EH	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
SHD2_k127_3298042_12	402881.Plav_2137	6.414e-182	576.0	COG1932@1|root,COG1932@2|Bacteria,1MUB5@1224|Proteobacteria,2TSHT@28211|Alphaproteobacteria,1JNMR@119043|Rhodobiaceae	28211|Alphaproteobacteria	EH	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine	serC	-	2.6.1.52	ko:K00831	ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230	M00020,M00124	R04173,R05085	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
SHD2_k127_3298042_94	231434.JQJH01000018_gene3047	2.711e-38	148.0	2E4J2@1|root,32ZE4@2|Bacteria,1N7YM@1224|Proteobacteria,2UBV9@28211|Alphaproteobacteria,3NBNA@45404|Beijerinckiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF3775)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3775
SHD2_k127_3298042_66	402881.Plav_0524	2.332e-72	247.0	COG0454@1|root,COG0456@2|Bacteria,1QUWI@1224|Proteobacteria,2TXQV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
SHD2_k127_3298042_78	717774.Marme_2811	4.821e-56	198.0	COG3791@1|root,COG3791@2|Bacteria,1RHWZ@1224|Proteobacteria,1S4HQ@1236|Gammaproteobacteria,1XM0X@135619|Oceanospirillales	135619|Oceanospirillales	S	Glutathione-dependent formaldehyde-activating enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GFA
SHD2_k127_3298042_62	402881.Plav_2134	1.893e-77	267.0	COG0384@1|root,COG0384@2|Bacteria,1MUAS@1224|Proteobacteria,2U3ND@28211|Alphaproteobacteria,1JNSJ@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Phenazine biosynthesis-like protein	-	-	-	-	-	-	-	-	-	-	-	-	PhzC-PhzF
SHD2_k127_3298042_27	402881.Plav_2159	9.087e-127	413.0	COG0568@1|root,COG0568@2|Bacteria,1MVWR@1224|Proteobacteria,2TR9Q@28211|Alphaproteobacteria,1JNJ7@119043|Rhodobiaceae	28211|Alphaproteobacteria	K	Sigma-70 factor, region 1.2	rpoH	-	-	ko:K03089	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r4
SHD2_k127_3298042_34	1244869.H261_12441	1.377e-112	372.0	COG0564@1|root,COG0564@2|Bacteria,1MUBN@1224|Proteobacteria,2TSBK@28211|Alphaproteobacteria,2JQ4Y@204441|Rhodospirillales	204441|Rhodospirillales	J	Responsible for synthesis of pseudouridine from uracil	rluD	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
SHD2_k127_3298042_114	1123366.TH3_08689	4.072e-14	78.0	COG1310@1|root,COG1310@2|Bacteria,1NC23@1224|Proteobacteria,2UGM4@28211|Alphaproteobacteria,2JTVQ@204441|Rhodospirillales	204441|Rhodospirillales	S	metal-dependent protease of the PAD1 JAB1 superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Prok-JAB
SHD2_k127_3298042_55	1205680.CAKO01000002_gene2262	3.791e-83	285.0	COG2897@1|root,COG2897@2|Bacteria,1MW4B@1224|Proteobacteria,2TR9R@28211|Alphaproteobacteria,2JQM2@204441|Rhodospirillales	204441|Rhodospirillales	P	Sulfurtransferase	-	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
SHD2_k127_3298042_48	1333998.M2A_1145	1.398e-91	309.0	COG0730@1|root,COG0730@2|Bacteria,1MVBS@1224|Proteobacteria,2TQW0@28211|Alphaproteobacteria,4BSU3@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
SHD2_k127_3298042_104	419610.Mext_1145	1.74e-23	103.0	COG0640@1|root,COG0640@2|Bacteria,1N72Q@1224|Proteobacteria,2UFSY@28211|Alphaproteobacteria,1JVH3@119045|Methylobacteriaceae	28211|Alphaproteobacteria	K	Transcriptional regulator	nolR	GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044212,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1903506,GO:2000112,GO:2001141	-	ko:K22042	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
SHD2_k127_3298042_25	1268622.AVS7_00200	4.24e-132	427.0	COG0491@1|root,COG0491@2|Bacteria,1MURA@1224|Proteobacteria,2VJYK@28216|Betaproteobacteria,4ABHP@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM beta-lactamase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
SHD2_k127_3298042_24	1297863.APJF01000013_gene3998	2.225e-137	443.0	COG2043@1|root,COG2043@2|Bacteria,1NR18@1224|Proteobacteria,2TVGP@28211|Alphaproteobacteria,3JU0D@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Uncharacterised ArCR, COG2043	MA20_36865	-	-	-	-	-	-	-	-	-	-	-	DUF169
SHD2_k127_3298042_39	1429916.X566_19625	2.974e-110	362.0	COG0300@1|root,COG0300@2|Bacteria,1R25N@1224|Proteobacteria,2TZB2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	NAD dependent epimerase/dehydratase family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
SHD2_k127_3298042_19	1382303.JPOM01000001_gene1419	3.327e-151	491.0	COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,2TUEW@28211|Alphaproteobacteria,2KFCU@204458|Caulobacterales	204458|Caulobacterales	EGP	major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like,MFS_2,Sugar_tr
SHD2_k127_3298042_63	551275.KB899546_gene2184	2.728e-77	271.0	COG0652@1|root,COG0652@2|Bacteria,1QCY4@1224|Proteobacteria,2U56N@28211|Alphaproteobacteria,43XD7@69657|Hyphomonadaceae	28211|Alphaproteobacteria	M	Peptidyl-prolyl cis-trans isomerase	-	-	5.2.1.8	ko:K01802	-	-	-	-	ko00000,ko01000	-	-	-	Pro_isomerase
SHD2_k127_3298042_3	349163.Acry_0895	2.715e-278	883.0	COG3391@1|root,COG3391@2|Bacteria,1R6BZ@1224|Proteobacteria,2U2WX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
SHD2_k127_3298042_43	1121949.AQXT01000002_gene1266	1.311e-102	342.0	COG1024@1|root,COG1024@2|Bacteria,1MVQN@1224|Proteobacteria,2UNSV@28211|Alphaproteobacteria,43ZQ0@69657|Hyphomonadaceae	28211|Alphaproteobacteria	I	Enoyl-CoA hydratase isomerase family protein	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
SHD2_k127_3298042_10	1380394.JADL01000012_gene859	3.171e-187	605.0	COG0628@1|root,COG0628@2|Bacteria,1MXXU@1224|Proteobacteria,2TV5E@28211|Alphaproteobacteria,2JW7E@204441|Rhodospirillales	204441|Rhodospirillales	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
SHD2_k127_3298042_53	1121033.AUCF01000008_gene5702	3.923e-84	294.0	COG0341@1|root,COG0341@2|Bacteria,1MU74@1224|Proteobacteria,2TSFW@28211|Alphaproteobacteria,2JQB0@204441|Rhodospirillales	204441|Rhodospirillales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	-	-	ko:K03072,ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
SHD2_k127_3298042_75	1122613.ATUP01000001_gene1435	2.396e-59	211.0	COG5400@1|root,COG5400@2|Bacteria,1RASG@1224|Proteobacteria,2U590@28211|Alphaproteobacteria,43XT9@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1134)	MA20_46305	-	-	-	-	-	-	-	-	-	-	-	DUF1134
SHD2_k127_3298042_28	1038860.AXAP01000007_gene6104	3.995e-122	400.0	COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,2TRUY@28211|Alphaproteobacteria,3JSWN@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	prohibitin homologues	qmcA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Band_7,Band_7_C
SHD2_k127_3298042_107	288000.BBta_1360	3.365e-20	97.0	COG1585@1|root,COG1585@2|Bacteria,1N241@1224|Proteobacteria,2UC8X@28211|Alphaproteobacteria,3JY4I@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	OU	NfeD-like C-terminal, partner-binding	MA20_06475	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K07340	-	-	-	-	ko00000	-	-	-	NfeD
SHD2_k127_3298042_118	570967.JMLV01000001_gene2643	1.074e-09	62.0	2EFX8@1|root,339PG@2|Bacteria,1NIZD@1224|Proteobacteria,2UKW4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_3298042_50	1333998.M2A_2966	1.667e-90	304.0	COG1218@1|root,COG1218@2|Bacteria,1N0GY@1224|Proteobacteria,2TT7B@28211|Alphaproteobacteria,4BQ56@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	P	Inositol monophosphatase family	cysQ	-	3.1.3.7	ko:K01082	ko00920,ko01100,ko01120,ko01130,map00920,map01100,map01120,map01130	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	Inositol_P
SHD2_k127_3298042_85	1411123.JQNH01000001_gene2354	4.429e-47	177.0	COG5385@1|root,COG5385@2|Bacteria,1MVEY@1224|Proteobacteria,2TSE6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	signal transduction histidine kinase	MA20_46320	-	-	ko:K13588	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001	-	-	-	HPTransfase
SHD2_k127_3298042_81	991905.SL003B_0950	3.156e-52	186.0	COG2199@1|root,COG3706@2|Bacteria,1RH2K@1224|Proteobacteria,2U9EP@28211|Alphaproteobacteria,4BQQ3@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	T	cheY-homologous receiver domain	cheY	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
SHD2_k127_3298042_60	1121033.AUCF01000004_gene4773	3.608e-79	273.0	COG1352@1|root,COG1352@2|Bacteria,1MU6W@1224|Proteobacteria,2TRQ3@28211|Alphaproteobacteria,2JQEI@204441|Rhodospirillales	204441|Rhodospirillales	NT	COG1352 Methylase of chemotaxis methyl-accepting proteins	-	-	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheR,CheR_N
SHD2_k127_3298042_109	1408419.JHYG01000005_gene569	5.251e-16	88.0	COG0454@1|root,COG0456@2|Bacteria,1RDVI@1224|Proteobacteria,2U7V7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
SHD2_k127_3298042_97	1030157.AFMP01000014_gene3410	1.618e-33	135.0	COG0346@1|root,COG0346@2|Bacteria,1RH79@1224|Proteobacteria,2UAPG@28211|Alphaproteobacteria,2K5QA@204457|Sphingomonadales	204457|Sphingomonadales	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
SHD2_k127_3298042_96	136993.KB900627_gene438	1.991e-37	145.0	COG3059@1|root,COG3059@2|Bacteria,1RBVI@1224|Proteobacteria,2U9NQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function, DUF417	-	-	-	-	-	-	-	-	-	-	-	-	DUF417
SHD2_k127_3298042_79	251221.35213251	7.012e-53	192.0	COG1846@1|root,COG1846@2|Bacteria,1G8VK@1117|Cyanobacteria	1117|Cyanobacteria	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2
SHD2_k127_3298042_0	1333998.M2A_1151	0.0	1328.0	COG0439@1|root,COG4770@1|root,COG4799@1|root,COG0439@2|Bacteria,COG4770@2|Bacteria,COG4799@2|Bacteria,1MU4H@1224|Proteobacteria,2TWYZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	carbamoyl-phosphate synthase	MA20_04765	-	-	-	-	-	-	-	-	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,Carboxyl_trans
SHD2_k127_3298042_38	69395.JQLZ01000005_gene3869	1.657e-110	383.0	COG4206@1|root,COG4206@2|Bacteria,1MW63@1224|Proteobacteria,2TT3G@28211|Alphaproteobacteria,2KFJZ@204458|Caulobacterales	204458|Caulobacterales	P	TonB-dependent Receptor Plug	-	-	-	ko:K16092	-	-	-	-	ko00000,ko02000	1.B.14.3	-	-	Plug,TonB_dep_Rec
SHD2_k127_3298042_99	195105.CN97_01145	1.422e-29	123.0	COG3807@1|root,COG3807@2|Bacteria,1RHM2@1224|Proteobacteria,2UA1R@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	protein conserved in bacteria	-	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	SH3_4
SHD2_k127_3298042_17	1282876.BAOK01000002_gene279	4.268e-155	506.0	COG2270@1|root,COG2270@2|Bacteria,1MWXB@1224|Proteobacteria,2TSCV@28211|Alphaproteobacteria,4BPRY@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Vacuole effluxer Atg22 like	MA20_25070	-	-	ko:K06902	ko04138,map04138	-	-	-	ko00000,ko00001,ko02000,ko04131	2.A.1.24,9.A.15.1	-	-	ATG22
SHD2_k127_3308966_0	1298867.AUES01000071_gene4393	1.438e-270	835.0	COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,2TQW9@28211|Alphaproteobacteria,3JSIR@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Cys/Met metabolism PLP-dependent enzyme	metY	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
SHD2_k127_3308966_1	1230476.C207_00837	1.082e-70	246.0	COG2908@1|root,COG2908@2|Bacteria,1MVKD@1224|Proteobacteria,2TSEB@28211|Alphaproteobacteria,3JSA7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Calcineurin-like phosphoesterase superfamily domain	MA20_08065	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Metallophos_2
SHD2_k127_3422154_3	1267005.KB911255_gene2387	6.252e-08	58.0	COG1961@1|root,COG1961@2|Bacteria,1PWCY@1224|Proteobacteria,2TVME@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG1961 Site-specific recombinases, DNA invertase Pin homologs	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
SHD2_k127_3422154_0	316058.RPB_2360	4.494e-155	494.0	COG2199@1|root,COG2202@1|root,COG2199@2|Bacteria,COG2202@2|Bacteria,1P3YR@1224|Proteobacteria,2TZ5R@28211|Alphaproteobacteria,3JYEG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,PAS,PAS_3
SHD2_k127_3422154_2	1192124.LIG30_4562	9.509e-25	109.0	COG1592@1|root,COG1592@2|Bacteria,1RC1F@1224|Proteobacteria,2W71P@28216|Betaproteobacteria,1KDJC@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
SHD2_k127_3422154_1	1163409.UUA_10381	8.174e-113	367.0	COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,1RPPQ@1236|Gammaproteobacteria,1X493@135614|Xanthomonadales	135614|Xanthomonadales	P	cytochrome c peroxidase	-	-	1.11.1.5	ko:K00428	-	-	-	-	ko00000,ko01000	-	-	-	CCP_MauG,Cytochrom_C
SHD2_k127_3433586_0	1411123.JQNH01000001_gene1612	1.94e-146	469.0	COG2421@1|root,COG2421@2|Bacteria,1MXKY@1224|Proteobacteria,2TSVA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Acetamidase formamidase	MA20_36855	-	-	-	-	-	-	-	-	-	-	-	FmdA_AmdA
SHD2_k127_3433586_4	1123060.JONP01000024_gene2531	1.018e-05	53.0	COG0673@1|root,COG0673@2|Bacteria,1MU8F@1224|Proteobacteria,2U12U@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
SHD2_k127_3433586_3	172088.AUGA01000001_gene6753	5.126e-06	52.0	COG0673@1|root,COG0673@2|Bacteria,1MU8F@1224|Proteobacteria,2U12U@28211|Alphaproteobacteria,3JX1N@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
SHD2_k127_3433586_1	1469245.JFBG01000086_gene1609	1.59e-79	275.0	COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,1S3RP@1236|Gammaproteobacteria,1WY4D@135613|Chromatiales	135613|Chromatiales	C	2Fe-2S -binding	-	-	1.2.5.3,1.3.99.16	ko:K03518,ko:K07302	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
SHD2_k127_3433586_2	196490.AUEZ01000135_gene4634	5.061e-53	190.0	COG1319@1|root,COG1319@2|Bacteria,1RCRH@1224|Proteobacteria,2TU08@28211|Alphaproteobacteria,3JSJE@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	CO dehydrogenase flavoprotein C-terminal domain	xdhB	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
SHD2_k127_3441647_1	488538.SAR116_1471	6.517e-41	156.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
SHD2_k127_3441647_0	1123504.JQKD01000012_gene1289	1.467e-117	383.0	COG1028@1|root,COG1028@2|Bacteria,1R6D6@1224|Proteobacteria	1224|Proteobacteria	IQ	short-chain dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
SHD2_k127_3441647_2	977880.RALTA_A2264	3.056e-18	86.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VK73@28216|Betaproteobacteria,1KDB0@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
SHD2_k127_346068_1	640511.BC1002_4820	8.188e-88	298.0	COG2515@1|root,COG2515@2|Bacteria,1MVYF@1224|Proteobacteria,2VJ6S@28216|Betaproteobacteria,1K2WD@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Pyridoxal-phosphate dependent enzyme	dcyD	-	3.5.99.7,4.4.1.15,4.4.1.25	ko:K01505,ko:K05396,ko:K17950	ko00270,map00270	-	R00997,R01874,R07634	RC00382,RC00419,RC01784	ko00000,ko00001,ko01000	-	-	-	PALP
SHD2_k127_346068_4	400682.PAC_15709570	2.762e-14	75.0	COG4631@1|root,KOG0430@2759|Eukaryota	2759|Eukaryota	C	xanthine catabolic process	-	-	1.17.1.4,1.17.3.2,1.2.3.1	ko:K00106,ko:K00157	ko00230,ko00232,ko00280,ko00350,ko00380,ko00750,ko00760,ko00830,ko00982,ko00983,ko01100,ko01110,ko01120,ko04146,ko04630,map00230,map00232,map00280,map00350,map00380,map00750,map00760,map00830,map00982,map00983,map01100,map01110,map01120,map04146,map04630	M00546	R01709,R01768,R01769,R02103,R02107,R02125,R02657,R03871,R04085,R04904,R07942,R07977,R07978,R07979,R08235,R08349,R08384,R08408	RC00075,RC00080,RC00143,RC00218,RC00242,RC01073,RC01074,RC02017,RC02199	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,CO_deh_flav_C,FAD_binding_5,Fer2,Fer2_2
SHD2_k127_346068_0	1469245.JFBG01000086_gene1608	4.577e-277	872.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,1RN40@1236|Gammaproteobacteria,1X2WW@135613|Chromatiales	1236|Gammaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	yagR	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016903,GO:0030151,GO:0033554,GO:0042597,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0055114	1.17.1.4	ko:K11177	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
SHD2_k127_346068_3	644107.SL1157_0407	2.944e-73	251.0	COG2080@1|root,COG2080@2|Bacteria,1MWA6@1224|Proteobacteria,2TS73@28211|Alphaproteobacteria,4NDS8@97050|Ruegeria	28211|Alphaproteobacteria	C	[2Fe-2S] binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer2,Fer2_2
SHD2_k127_346068_2	266835.14022846	2.186e-85	289.0	COG1319@1|root,COG1319@2|Bacteria,1RCRH@1224|Proteobacteria,2TU08@28211|Alphaproteobacteria,43PT0@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM	xdhB	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
SHD2_k127_3467653_21	366602.Caul_5439	3.713e-155	496.0	COG3239@1|root,COG3239@2|Bacteria,1MW29@1224|Proteobacteria,2TSHW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Alkane 1-monooxygenase	-	-	1.14.15.3	ko:K00496	ko00071,ko00930,map00071,map00930	-	R01347,R02281,R06945	RC00478	ko00000,ko00001,ko01000	-	-	-	FA_desaturase
SHD2_k127_3467653_80	875328.JDM601_2990	1.282e-20	93.0	COG1773@1|root,COG1773@2|Bacteria,2GQUH@201174|Actinobacteria,23B9H@1762|Mycobacteriaceae	201174|Actinobacteria	C	Belongs to the rubredoxin family	rubA	-	-	-	-	-	-	-	-	-	-	-	Rubredoxin
SHD2_k127_3467653_9	1333998.M2A_2787	1.231e-207	651.0	COG2159@1|root,COG2159@2|Bacteria,1N0C7@1224|Proteobacteria,2TRXY@28211|Alphaproteobacteria,4BSZR@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Amidohydrolase	MA20_19310	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
SHD2_k127_3467653_22	1205680.CAKO01000001_gene3142	2.032e-141	454.0	COG2175@1|root,COG2175@2|Bacteria,1MVI6@1224|Proteobacteria	1224|Proteobacteria	Q	taurine catabolism dioxygenase	-	-	1.14.11.17	ko:K03119	ko00430,ko00920,map00430,map00920	-	R05320	RC01331	ko00000,ko00001,ko01000	-	-	-	TauD
SHD2_k127_3467653_51	402881.Plav_2010	6.289e-64	222.0	COG1545@1|root,COG1545@2|Bacteria,1R44D@1224|Proteobacteria,2U5BU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Rubredoxin-like zinc ribbon domain (DUF35_N)	MA20_16300	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
SHD2_k127_3467653_10	402881.Plav_2009	1.155e-200	631.0	COG0183@1|root,COG0183@2|Bacteria,1MUZV@1224|Proteobacteria,2TRHF@28211|Alphaproteobacteria,1JPBG@119043|Rhodobiaceae	28211|Alphaproteobacteria	I	acetyl-coa acetyltransferase	MA20_16305	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C
SHD2_k127_3467653_24	509190.Cseg_2065	5.855e-130	427.0	2C3QV@1|root,2Z7YP@2|Bacteria,1MXAM@1224|Proteobacteria,2UPR9@28211|Alphaproteobacteria,2KI6P@204458|Caulobacterales	204458|Caulobacterales	S	Alginate export	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_exp
SHD2_k127_3467653_7	395965.Msil_1519	3.844e-216	679.0	COG2010@1|root,COG2132@1|root,COG2010@2|Bacteria,COG2132@2|Bacteria,1MV74@1224|Proteobacteria,2U1BK@28211|Alphaproteobacteria,3NCM5@45404|Beijerinckiaceae	28211|Alphaproteobacteria	C	Multicopper oxidase	-	-	1.7.2.1	ko:K00368	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000	-	-	-	Copper-bind,Cu-oxidase_2,Cu-oxidase_3,Cytochrom_C
SHD2_k127_3467653_49	395965.Msil_1520	1.431e-65	233.0	COG1262@1|root,COG1262@2|Bacteria,1RAP4@1224|Proteobacteria	1224|Proteobacteria	S	signal peptide protein	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
SHD2_k127_3467653_63	395965.Msil_1521	3.44e-48	181.0	COG1999@1|root,COG1999@2|Bacteria,1N5E3@1224|Proteobacteria	1224|Proteobacteria	S	protein SCO1 SenC PrrC involved in biogenesis of respiratory and photosynthetic systems	-	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	SCO1-SenC
SHD2_k127_3467653_35	570967.JMLV01000004_gene561	9.87e-104	354.0	COG3213@1|root,COG3213@2|Bacteria,1MUJK@1224|Proteobacteria,2TSQ2@28211|Alphaproteobacteria,2JRD2@204441|Rhodospirillales	204441|Rhodospirillales	P	protein involved in response to NO	-	-	-	ko:K07234	-	-	-	-	ko00000	-	-	-	NnrS
SHD2_k127_3467653_60	622637.KE124774_gene585	7.888e-52	187.0	2AH4X@1|root,317EK@2|Bacteria,1RHUE@1224|Proteobacteria,2UADH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_3467653_90	398512.JQKC01000023_gene3281	3.677e-08	55.0	2DPV4@1|root,333HA@2|Bacteria,1VH7Z@1239|Firmicutes,24SC2@186801|Clostridia,3WQ8C@541000|Ruminococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_3467653_83	460265.Mnod_3343	3.526e-16	80.0	COG3024@1|root,COG3024@2|Bacteria,1NGJ8@1224|Proteobacteria,2UJJF@28211|Alphaproteobacteria,1JWTX@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase	yacG	-	-	ko:K09862	-	-	-	-	ko00000	-	-	-	YacG
SHD2_k127_3467653_18	402881.Plav_0528	6.097e-172	555.0	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,2TRX2@28211|Alphaproteobacteria,1JN1V@119043|Rhodobiaceae	28211|Alphaproteobacteria	J	Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs	-	-	-	ko:K08301	-	-	-	-	ko00000,ko01000,ko03009,ko03019	-	-	-	RNase_E_G
SHD2_k127_3467653_57	1038858.AXBA01000002_gene3973	7.76e-55	198.0	COG0424@1|root,COG0424@2|Bacteria,1RH6H@1224|Proteobacteria,2TSS5@28211|Alphaproteobacteria,3EZCE@335928|Xanthobacteraceae	28211|Alphaproteobacteria	D	Maf-like protein	maf	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
SHD2_k127_3467653_75	1123267.JONN01000001_gene2022	2.914e-28	121.0	COG0361@1|root,COG0361@2|Bacteria,1MZFU@1224|Proteobacteria,2UBRU@28211|Alphaproteobacteria,2K5VJ@204457|Sphingomonadales	204457|Sphingomonadales	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	-	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
SHD2_k127_3467653_84	366602.Caul_4398	1.55e-14	84.0	COG4520@1|root,COG5455@1|root,COG4520@2|Bacteria,COG5455@2|Bacteria	2|Bacteria	D	response to cobalt ion	yohN	GO:0003674,GO:0005488,GO:0005507,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0010033,GO:0010035,GO:0010038,GO:0010045,GO:0010243,GO:0030288,GO:0030313,GO:0031975,GO:0032025,GO:0033554,GO:0042221,GO:0042597,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:1901652,GO:1901698,GO:1901700	-	-	-	-	-	-	-	-	-	-	17kDa_Anti_2,Gly-zipper_Omp,RcnB,Rick_17kDa_Anti
SHD2_k127_3467653_58	631454.N177_2938	1.885e-54	194.0	COG0394@1|root,COG0394@2|Bacteria,1RANV@1224|Proteobacteria,2U5EE@28211|Alphaproteobacteria,1JP9H@119043|Rhodobiaceae	28211|Alphaproteobacteria	T	Low molecular weight phosphatase family	MA20_21085	-	1.20.4.1,3.1.3.48	ko:K01104,ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
SHD2_k127_3467653_46	1333998.M2A_3019	1.111e-70	241.0	COG5328@1|root,COG5328@2|Bacteria,1RA93@1224|Proteobacteria,2U741@28211|Alphaproteobacteria,4BQPS@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Uncharacterised protein family (UPF0262)	MA20_21090	-	-	-	-	-	-	-	-	-	-	-	UPF0262
SHD2_k127_3467653_15	402881.Plav_0521	5.307e-176	562.0	COG0141@1|root,COG0141@2|Bacteria,1MUUF@1224|Proteobacteria,2TSBN@28211|Alphaproteobacteria,1JNFI@119043|Rhodobiaceae	28211|Alphaproteobacteria	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
SHD2_k127_3467653_71	69279.BG36_18995	5.9e-35	138.0	2CN5Z@1|root,32SGB@2|Bacteria,1N1FB@1224|Proteobacteria,2UBV1@28211|Alphaproteobacteria,43KA8@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF2948)	MA20_21100	-	-	-	-	-	-	-	-	-	-	-	DUF2948
SHD2_k127_3467653_20	1120983.KB894574_gene1092	5.602e-158	509.0	COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,2TRPH@28211|Alphaproteobacteria,1JMZK@119043|Rhodobiaceae	28211|Alphaproteobacteria	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
SHD2_k127_3467653_36	1089551.KE386572_gene4258	1.538e-93	323.0	COG5473@1|root,COG5473@2|Bacteria,1MVRU@1224|Proteobacteria,2TRUD@28211|Alphaproteobacteria,4BRAQ@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Predicted integral membrane protein (DUF2189)	MA20_41380	-	-	-	-	-	-	-	-	-	-	-	DUF2189
SHD2_k127_3467653_30	1476583.DEIPH_ctg019orf0031	1.593e-109	361.0	COG0667@1|root,COG0667@2|Bacteria	2|Bacteria	C	Aldo Keto reductase	ydbC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	1.1.1.65	ko:K05275	ko00750,ko01100,ko01120,map00750,map01100,map01120	-	R01708	RC00116	ko00000,ko00001,ko01000	-	-	-	Aldo_ket_red
SHD2_k127_3467653_87	215803.DB30_3822	7.201e-09	67.0	2E9YS@1|root,3344A@2|Bacteria,1NKBF@1224|Proteobacteria,432EE@68525|delta/epsilon subdivisions,2WY2K@28221|Deltaproteobacteria,2Z24V@29|Myxococcales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF3592)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3592
SHD2_k127_3467653_17	366602.Caul_0139	1.077e-173	552.0	COG0208@1|root,COG0208@2|Bacteria,1MU53@1224|Proteobacteria,2U2W4@28211|Alphaproteobacteria,2KG1U@204458|Caulobacterales	204458|Caulobacterales	F	Long-chain fatty aldehyde decarbonylase	-	-	-	-	-	-	-	-	-	-	-	-	Ald_deCOase
SHD2_k127_3467653_11	1449049.JONW01000006_gene2651	4.064e-191	604.0	COG2124@1|root,COG2124@2|Bacteria,1MV8Q@1224|Proteobacteria,2TRWW@28211|Alphaproteobacteria,2KHW8@204458|Caulobacterales	204458|Caulobacterales	C	cytochrome P450	-	-	-	-	-	-	-	-	-	-	-	-	p450
SHD2_k127_3467653_13	1122614.JHZF01000001_gene339	5.578e-179	569.0	COG2124@1|root,COG2124@2|Bacteria,1MV8Q@1224|Proteobacteria,2TRWW@28211|Alphaproteobacteria,2PD30@252301|Oceanicola	28211|Alphaproteobacteria	Q	Cytochrome P450	-	-	-	-	-	-	-	-	-	-	-	-	p450
SHD2_k127_3467653_68	450851.PHZ_c0215	9.175e-43	159.0	COG0633@1|root,COG0633@2|Bacteria,1RHDC@1224|Proteobacteria,2U97J@28211|Alphaproteobacteria,2KGS1@204458|Caulobacterales	204458|Caulobacterales	C	ferredoxin	-	-	-	ko:K04755	-	-	-	-	ko00000	-	-	-	Fer2
SHD2_k127_3467653_16	509190.Cseg_0209	1.142e-175	560.0	COG0208@1|root,COG0208@2|Bacteria,1MU53@1224|Proteobacteria,2U2W4@28211|Alphaproteobacteria,2KG1U@204458|Caulobacterales	204458|Caulobacterales	F	Long-chain fatty aldehyde decarbonylase	-	-	-	-	-	-	-	-	-	-	-	-	Ald_deCOase
SHD2_k127_3467653_76	717785.HYPMC_4914	6.683e-27	117.0	COG1309@1|root,COG1309@2|Bacteria,1NB71@1224|Proteobacteria,2UI2W@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
SHD2_k127_3467653_88	1230476.C207_00359	1.018e-08	59.0	COG0654@1|root,COG0654@2|Bacteria,1MXEW@1224|Proteobacteria,2TRRC@28211|Alphaproteobacteria,3JV1F@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	CH	Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	MA20_42420	-	1.14.13.218	ko:K20940	ko00405,ko01130,map00405,map01130	M00835	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_3
SHD2_k127_3467653_3	83406.HDN1F_02570	1.152e-249	783.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1RMQ4@1236|Gammaproteobacteria,1J8FQ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	IQ	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
SHD2_k127_3467653_8	573065.Astex_3082	8.845e-214	666.0	COG1062@1|root,COG1062@2|Bacteria,1MUK4@1224|Proteobacteria,2TT67@28211|Alphaproteobacteria,2KFG5@204458|Caulobacterales	204458|Caulobacterales	C	Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily	-	-	1.1.1.1,1.1.1.284	ko:K00121	ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
SHD2_k127_3467653_40	58344.JOEL01000001_gene392	9.197e-88	300.0	COG2175@1|root,COG2175@2|Bacteria,2GNUC@201174|Actinobacteria	201174|Actinobacteria	Q	taurine catabolism dioxygenase	-	-	1.14.11.17	ko:K03119	ko00430,ko00920,map00430,map00920	-	R05320	RC01331	ko00000,ko00001,ko01000	-	-	-	TauD
SHD2_k127_3467653_89	1125973.JNLC01000011_gene224	1.305e-08	59.0	2DR1A@1|root,339RT@2|Bacteria,1NGFB@1224|Proteobacteria	1224|Proteobacteria	S	Protein of unknown function (DUF3096)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3096
SHD2_k127_3467653_34	414684.RC1_1776	1.783e-104	353.0	COG0334@1|root,COG0334@2|Bacteria,1MUXS@1224|Proteobacteria,2VGKD@28211|Alphaproteobacteria,2JP8T@204441|Rhodospirillales	204441|Rhodospirillales	E	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase	-	-	1.4.1.9	ko:K00263	ko00280,ko00290,ko01100,ko01110,ko01130,map00280,map00290,map01100,map01110,map01130	-	R01088,R01434,R02196	RC00006,RC00036	ko00000,ko00001,ko01000	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
SHD2_k127_3467653_0	1380394.JADL01000002_gene1193	0.0	1347.0	COG1014@1|root,COG4231@1|root,COG1014@2|Bacteria,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,2TSHH@28211|Alphaproteobacteria,2JQ67@204441|Rhodospirillales	204441|Rhodospirillales	C	COG4231 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits	-	-	1.2.7.8	ko:K04090	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR,TPP_enzyme_C
SHD2_k127_3467653_28	450851.PHZ_c1409	2.724e-115	379.0	COG3186@1|root,COG3186@2|Bacteria,1MU29@1224|Proteobacteria,2TU1E@28211|Alphaproteobacteria,2KFHY@204458|Caulobacterales	204458|Caulobacterales	E	Phenylalanine-4-hydroxylase	phhA	-	1.14.16.1	ko:K00500	ko00360,ko00400,ko00790,ko01100,ko01230,map00360,map00400,map00790,map01100,map01230	-	R01795,R07211	RC00490	ko00000,ko00001,ko01000	-	-	-	Biopterin_H
SHD2_k127_3467653_23	402881.Plav_0389	1.733e-131	427.0	COG2267@1|root,COG2267@2|Bacteria,1QTAP@1224|Proteobacteria,2TU8W@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
SHD2_k127_3467653_78	247634.GPB2148_4	3.773e-23	106.0	2E1J6@1|root,32WWW@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_3467653_19	1292034.OR37_00714	6.947e-168	554.0	COG4232@1|root,COG4233@1|root,COG4232@2|Bacteria,COG4233@2|Bacteria,1MU8W@1224|Proteobacteria,2TTUM@28211|Alphaproteobacteria,2KF2F@204458|Caulobacterales	204458|Caulobacterales	CO	cytochrome c biogenesis protein	-	-	1.8.1.8	ko:K04084	-	-	-	-	ko00000,ko01000,ko03110	5.A.1.1	-	-	DsbC,DsbD,Thioredoxin_7
SHD2_k127_3467653_32	1172185.KB911533_gene35	2.072e-105	356.0	COG2130@1|root,COG2130@2|Bacteria,2GKR8@201174|Actinobacteria,4FVAH@85025|Nocardiaceae	201174|Actinobacteria	S	N-terminal domain of oxidoreductase	-	-	-	ko:K07119	-	-	-	-	ko00000	-	-	-	ADH_N_2,ADH_zinc_N
SHD2_k127_3467653_55	717785.HYPMC_3834	5.05e-58	207.0	COG0742@1|root,COG0742@2|Bacteria,1MXKW@1224|Proteobacteria,2U70Y@28211|Alphaproteobacteria,3N6TT@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Methyltransferase	rsmD	-	2.1.1.171	ko:K08316	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Cons_hypoth95
SHD2_k127_3467653_52	1187851.A33M_0368	1.043e-61	228.0	2FDS6@1|root,345T2@2|Bacteria,1N2JF@1224|Proteobacteria,2UE9R@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SHD2_k127_3467653_65	1297865.APJD01000022_gene355	4.236e-45	172.0	COG0454@1|root,COG0456@2|Bacteria,1N3WW@1224|Proteobacteria,2U0YR@28211|Alphaproteobacteria,3JWJI@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
SHD2_k127_3467653_41	1217720.ALOX01000060_gene2829	1.34e-84	284.0	COG0625@1|root,COG0625@2|Bacteria,1MWUG@1224|Proteobacteria,2TTZ6@28211|Alphaproteobacteria,2JWX6@204441|Rhodospirillales	204441|Rhodospirillales	O	Glutathione S-transferase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	GST_C
SHD2_k127_3467653_86	883080.HMPREF9697_04044	5.509e-10	65.0	COG2199@1|root,COG3706@2|Bacteria,1R1XK@1224|Proteobacteria,2TZ6S@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	PilZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PilZ
SHD2_k127_3467653_6	1282876.BAOK01000001_gene2964	5.247e-224	711.0	COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,2TR2M@28211|Alphaproteobacteria,4BPE7@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
SHD2_k127_3467653_26	402881.Plav_0292	1.185e-118	395.0	COG0166@1|root,COG0166@2|Bacteria,1MUFP@1224|Proteobacteria,2TQKP@28211|Alphaproteobacteria,1JPEX@119043|Rhodobiaceae	28211|Alphaproteobacteria	G	Phosphoglucose isomerase	pgi	-	5.3.1.9	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI
SHD2_k127_3467653_79	1380394.JADL01000003_gene5093	5.522e-22	104.0	2C068@1|root,30N9J@2|Bacteria,1RG08@1224|Proteobacteria,2UBBZ@28211|Alphaproteobacteria,2JS3N@204441|Rhodospirillales	204441|Rhodospirillales	S	Protein of unknown function (DUF3035)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3035
SHD2_k127_3467653_69	652103.Rpdx1_4593	6.991e-40	154.0	COG0597@1|root,COG0597@2|Bacteria,1RGV9@1224|Proteobacteria,2UBUC@28211|Alphaproteobacteria,3JT06@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	MU	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	lspA	-	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
SHD2_k127_3467653_1	1333998.M2A_1461	0.0	1154.0	COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,2TR3N@28211|Alphaproteobacteria,4BP8X@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
SHD2_k127_3467653_56	1333998.M2A_2407	4.627e-55	197.0	COG1247@1|root,COG1247@2|Bacteria,1NKJU@1224|Proteobacteria,2UH94@28211|Alphaproteobacteria,4BSGU@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	M	Acetyltransferase (GNAT) domain	-	-	-	ko:K03830	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_10
SHD2_k127_3467653_33	402881.Plav_0641	1.454e-104	349.0	COG0196@1|root,COG0196@2|Bacteria,1MV9I@1224|Proteobacteria,2TTUY@28211|Alphaproteobacteria,1JN6B@119043|Rhodobiaceae	28211|Alphaproteobacteria	H	Riboflavin kinase	ribF	-	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
SHD2_k127_3467653_64	1304883.KI912532_gene1602	2.524e-47	173.0	COG2030@1|root,COG2030@2|Bacteria,1MWPK@1224|Proteobacteria,2VREB@28216|Betaproteobacteria,2KWED@206389|Rhodocyclales	206389|Rhodocyclales	I	N-terminal half of MaoC dehydratase	-	-	4.2.1.55	ko:K17865	ko00630,ko00650,ko01120,ko01200,map00630,map00650,map01120,map01200	M00373	R03027	RC00831	ko00000,ko00001,ko00002,ko01000	-	-	-	MaoC_dehydratas
SHD2_k127_3467653_43	1122929.KB908215_gene1060	7.501e-80	274.0	COG0647@1|root,COG0647@2|Bacteria,1MU9Y@1224|Proteobacteria,2TUH0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	sugar phosphatases of the HAD superfamily	MA20_05625	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_6,Hydrolase_like
SHD2_k127_3467653_39	1282876.BAOK01000001_gene2975	4.846e-91	314.0	COG2200@1|root,COG2200@2|Bacteria,1MU4F@1224|Proteobacteria,2TU9M@28211|Alphaproteobacteria,4BQIZ@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	T	Putative diguanylate phosphodiesterase	MA20_05620	-	-	ko:K13593	ko04112,map04112	-	-	-	ko00000,ko00001	-	-	-	EAL
SHD2_k127_3467653_47	675635.Psed_4309	1.596e-70	249.0	COG0596@1|root,COG0596@2|Bacteria,2GKJB@201174|Actinobacteria	201174|Actinobacteria	EGP	Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons	dhmA	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	3.8.1.5	ko:K01563	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05284,R05367,R05368,R05369,R05370,R07669,R07670	RC01317,RC01340,RC01341,RC02013	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
SHD2_k127_3467653_53	1238182.C882_3851	7.302e-59	209.0	COG0386@1|root,COG0386@2|Bacteria,1RD1R@1224|Proteobacteria,2TU17@28211|Alphaproteobacteria,2JSXW@204441|Rhodospirillales	204441|Rhodospirillales	O	Belongs to the glutathione peroxidase family	-	-	1.11.1.9	ko:K00432	ko00480,ko00590,ko04918,map00480,map00590,map04918	-	R00274,R07034,R07035	RC00011,RC00982	ko00000,ko00001,ko01000	-	-	-	GSHPx
SHD2_k127_3467653_81	640512.BC1003_1944	2.275e-18	95.0	2B41E@1|root,31WRS@2|Bacteria,1P8VA@1224|Proteobacteria,2VSE9@28216|Betaproteobacteria,1K0YA@119060|Burkholderiaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_3467653_82	861208.AGROH133_09087	3.327e-17	93.0	COG2885@1|root,COG2885@2|Bacteria,1MYBP@1224|Proteobacteria,2U787@28211|Alphaproteobacteria,4B876@82115|Rhizobiaceae	28211|Alphaproteobacteria	M	Belongs to the ompA family	yiaD	-	-	-	-	-	-	-	-	-	-	-	Gly-zipper_Omp,Gly-zipper_YMGG,OmpA
SHD2_k127_3467653_27	402881.Plav_0273	5.638e-116	377.0	COG1028@1|root,COG1028@2|Bacteria,1MWGC@1224|Proteobacteria,2TSNX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	IQ	short-chain dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
SHD2_k127_3467653_14	402881.Plav_1557	2.978e-176	559.0	COG0686@1|root,COG0686@2|Bacteria,1QTX1@1224|Proteobacteria,2TQQC@28211|Alphaproteobacteria,1JNE5@119043|Rhodobiaceae	28211|Alphaproteobacteria	E	Alanine dehydrogenase/PNT, N-terminal domain	ald	-	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
SHD2_k127_3467653_12	652103.Rpdx1_1349	7.94e-180	572.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2TQND@28211|Alphaproteobacteria,3JRVX@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.18,2.6.1.62	ko:K00822,ko:K00833	ko00280,ko00410,ko00640,ko00780,ko01100,map00280,map00410,map00640,map00780,map01100	M00123,M00573,M00577	R00907,R03231,R04187	RC00006,RC00008,RC00062,RC00160,RC00887	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
SHD2_k127_3467653_62	1395587.P364_0100595	7.712e-49	179.0	COG0454@1|root,COG0456@2|Bacteria,1V81Z@1239|Firmicutes,4HIXF@91061|Bacilli,275IW@186822|Paenibacillaceae	91061|Bacilli	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_7
SHD2_k127_3467653_25	1333998.M2A_1430	8.9e-129	421.0	COG3616@1|root,COG3616@2|Bacteria,1MVQE@1224|Proteobacteria,2TSQ3@28211|Alphaproteobacteria,4BQ7A@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Putative serine dehydratase domain	-	-	-	-	-	-	-	-	-	-	-	-	Ala_racemase_N,D-ser_dehydrat
SHD2_k127_3467653_67	1090320.KB900605_gene3222	2.066e-43	169.0	COG0697@1|root,COG0697@2|Bacteria,1R46X@1224|Proteobacteria,2TSE9@28211|Alphaproteobacteria,2K44M@204457|Sphingomonadales	204457|Sphingomonadales	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA,Multi_Drug_Res
SHD2_k127_3467653_5	452662.SJA_C2-03820	1.856e-229	719.0	COG2368@1|root,COG2368@2|Bacteria,1PEQG@1224|Proteobacteria,2TVQ7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	4-hydroxyphenylacetate 3-hydroxylase	-	-	4.2.1.120,5.3.3.3	ko:K14534	ko00650,ko00720,ko01100,ko01120,ko01200,map00650,map00720,map01100,map01120,map01200	M00374,M00375	R03031,R10782	RC01857,RC03277	ko00000,ko00001,ko00002,ko01000	-	-	-	HpaB,HpaB_N
SHD2_k127_3467653_29	1122929.KB908215_gene1352	8.332e-113	373.0	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,2TRRH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	BQ	COG0123 Deacetylases, including yeast histone deacetylase and acetoin utilization protein	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
SHD2_k127_3467653_61	450851.PHZ_c2592	1.711e-51	188.0	COG0625@1|root,COG0625@2|Bacteria,1RA05@1224|Proteobacteria,2TS58@28211|Alphaproteobacteria,2KGC9@204458|Caulobacterales	28211|Alphaproteobacteria	O	Glutathione S-transferase, N-terminal domain	gst1	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_2,GST_N,GST_N_3
SHD2_k127_3467653_74	1161401.ASJA01000003_gene2770	6.127e-31	127.0	COG3409@1|root,COG3409@2|Bacteria,1NP3I@1224|Proteobacteria,2UM8V@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Peptidoglycan-binding domain 1 protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_3467653_42	1297865.APJD01000020_gene97	6.289e-80	275.0	COG0030@1|root,COG0030@2|Bacteria,1R0K7@1224|Proteobacteria,2U8JF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Ribosomal RNA adenine dimethylase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
SHD2_k127_3467653_44	765910.MARPU_08750	2.825e-78	267.0	COG5587@1|root,COG5587@2|Bacteria,1R8B4@1224|Proteobacteria,1S1WW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	PFAM conserved	-	-	-	-	-	-	-	-	-	-	-	-	DUF2461
SHD2_k127_3467653_73	358220.C380_19310	7.571e-32	131.0	COG2050@1|root,COG2050@2|Bacteria,1RHP8@1224|Proteobacteria,2VY16@28216|Betaproteobacteria,4AFY8@80864|Comamonadaceae	28216|Betaproteobacteria	Q	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
SHD2_k127_3467653_91	1121438.JNJA01000012_gene1567	1.621e-06	58.0	COG0412@1|root,COG0412@2|Bacteria,1R6AF@1224|Proteobacteria,435Y4@68525|delta/epsilon subdivisions,2X0EZ@28221|Deltaproteobacteria,2MC35@213115|Desulfovibrionales	28221|Deltaproteobacteria	Q	Phospholipase/Carboxylesterase	-	-	-	-	-	-	-	-	-	-	-	-	DLH
SHD2_k127_3467653_72	1121033.AUCF01000020_gene660	4.523e-32	126.0	COG5425@1|root,COG5425@2|Bacteria,1N08I@1224|Proteobacteria,2UBVR@28211|Alphaproteobacteria,2JUAM@204441|Rhodospirillales	204441|Rhodospirillales	E	Usg-like family	-	-	-	-	-	-	-	-	-	-	-	-	Usg
SHD2_k127_3467653_66	1267005.KB911256_gene2030	6.759e-45	166.0	COG0234@1|root,COG0234@2|Bacteria,1MZ2X@1224|Proteobacteria,2U9AQ@28211|Alphaproteobacteria,3N72T@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009987,GO:0010033,GO:0035966,GO:0042221,GO:0043167,GO:0043169,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0061077	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
SHD2_k127_3467653_2	1333998.M2A_1426	8.655e-271	841.0	COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,2TS07@28211|Alphaproteobacteria,4BP5H@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
SHD2_k127_3467653_77	1307759.JOMJ01000003_gene267	4.069e-25	119.0	COG1086@1|root,COG1086@2|Bacteria,1QZ5G@1224|Proteobacteria,43CG5@68525|delta/epsilon subdivisions	1224|Proteobacteria	GM	Methyltransferase FkbM domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_21
SHD2_k127_3467653_54	1245471.PCA10_34900	3.747e-58	209.0	COG3812@1|root,COG3812@2|Bacteria,1RGUV@1224|Proteobacteria,1S6J5@1236|Gammaproteobacteria,1YGB9@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	Domain of unknown function (DUF1993)	-	-	-	ko:K09983	-	-	-	-	ko00000	-	-	-	DUF1993
SHD2_k127_3467653_59	913325.N799_00910	2.748e-52	191.0	COG0526@1|root,COG0526@2|Bacteria,1QU2B@1224|Proteobacteria,1T1N1@1236|Gammaproteobacteria,1XD4R@135614|Xanthomonadales	135614|Xanthomonadales	O	Thioredoxin	-	-	1.8.1.8	ko:K03672	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Thioredoxin
SHD2_k127_3467653_93	1123240.ATVO01000009_gene715	3.453e-05	51.0	2EQ70@1|root,33HT9@2|Bacteria,1NIHT@1224|Proteobacteria,2UK3J@28211|Alphaproteobacteria,2K5XI@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_3467653_4	1110502.TMO_0780	1.709e-240	764.0	COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,2TQWI@28211|Alphaproteobacteria,2JQ7K@204441|Rhodospirillales	28211|Alphaproteobacteria	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
SHD2_k127_3467653_48	402881.Plav_0207	1.138e-66	232.0	COG0290@1|root,COG0290@2|Bacteria,1RDD2@1224|Proteobacteria,2U58Z@28211|Alphaproteobacteria,1JP7Q@119043|Rhodobiaceae	28211|Alphaproteobacteria	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
SHD2_k127_3467653_92	287.DR97_1207	6.72e-06	56.0	2D596@1|root,32TII@2|Bacteria,1N3RK@1224|Proteobacteria,1S867@1236|Gammaproteobacteria,1YDG2@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_3467653_38	1380394.JADL01000011_gene3870	4.808e-91	315.0	COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,2TQN9@28211|Alphaproteobacteria,2JQE6@204441|Rhodospirillales	204441|Rhodospirillales	E	Pyridoxal-phosphate dependent enzyme	-	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
SHD2_k127_3467653_37	1417296.U879_11855	5.508e-93	316.0	COG0598@1|root,COG0598@2|Bacteria,1MWMP@1224|Proteobacteria,2TQQD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	PFAM Mg2 transporter protein CorA family protein	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
SHD2_k127_3467653_50	1411123.JQNH01000001_gene1920	1.942e-65	234.0	COG0697@1|root,COG0697@2|Bacteria,1MZXM@1224|Proteobacteria,2TSZM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EG	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
SHD2_k127_3467653_85	1191523.MROS_2453	3.591e-14	80.0	COG0727@1|root,COG0727@2|Bacteria	2|Bacteria	S	metal cluster binding	-	-	-	ko:K06940,ko:K18475	-	-	-	-	ko00000,ko01000,ko02035	-	-	-	CxxCxxCC
SHD2_k127_3467653_45	207559.Dde_3043	9.845e-73	257.0	COG1181@1|root,COG1181@2|Bacteria,1N4F5@1224|Proteobacteria,42NYM@68525|delta/epsilon subdivisions,2WKTX@28221|Deltaproteobacteria,2M925@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Belongs to the D-alanine--D-alanine ligase family	ddlB1	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
SHD2_k127_3467653_31	1499967.BAYZ01000028_gene1264	1.474e-108	361.0	COG1181@1|root,COG1181@2|Bacteria,2NRF0@2323|unclassified Bacteria	2|Bacteria	M	ATP-grasp domain	ddlA	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
SHD2_k127_3467653_70	1121861.KB899916_gene1707	1.034e-36	139.0	COG1509@1|root,COG1509@2|Bacteria,1MUPJ@1224|Proteobacteria,2TT31@28211|Alphaproteobacteria,2JPK9@204441|Rhodospirillales	204441|Rhodospirillales	E	lysine 2,3-aminomutase	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
SHD2_k127_3494226_9	631454.N177_2529	7.051e-139	449.0	COG0216@1|root,COG0216@2|Bacteria,1MV28@1224|Proteobacteria,2TQSV@28211|Alphaproteobacteria,1JN9T@119043|Rhodobiaceae	28211|Alphaproteobacteria	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
SHD2_k127_3494226_19	1380394.JADL01000021_gene1855	6.295e-70	247.0	COG2890@1|root,COG2890@2|Bacteria,1MXCQ@1224|Proteobacteria,2TZFK@28211|Alphaproteobacteria,2JQMD@204441|Rhodospirillales	204441|Rhodospirillales	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS,Methyltransf_25,Methyltransf_31
SHD2_k127_3494226_28	1054213.HMPREF9946_02409	1.436e-21	100.0	COG5373@1|root,COG5373@2|Bacteria,1N7JV@1224|Proteobacteria,2TR7A@28211|Alphaproteobacteria,2JTYQ@204441|Rhodospirillales	204441|Rhodospirillales	K	Domain of unknown function (DUF4167)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4167
SHD2_k127_3494226_16	1242864.D187_005794	3.499e-83	292.0	COG0477@1|root,COG2814@2|Bacteria,1R3YS@1224|Proteobacteria,43B23@68525|delta/epsilon subdivisions,2X5HF@28221|Deltaproteobacteria,2YVY1@29|Myxococcales	28221|Deltaproteobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
SHD2_k127_3494226_0	187303.BN69_0822	0.0	1285.0	COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,2TRKI@28211|Alphaproteobacteria,36XV5@31993|Methylocystaceae	28211|Alphaproteobacteria	O	C-terminal, D2-small domain, of ClpB protein	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
SHD2_k127_3494226_11	402881.Plav_1754	4.291e-101	349.0	COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,2TT3Z@28211|Alphaproteobacteria,1JNPG@119043|Rhodobiaceae	28211|Alphaproteobacteria	M	Peptidase family M23	nlpD2	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
SHD2_k127_3494226_18	666685.R2APBS1_1312	4.176e-72	254.0	COG4709@1|root,COG4709@2|Bacteria,1NX5K@1224|Proteobacteria,1SPS6@1236|Gammaproteobacteria,1X34I@135614|Xanthomonadales	135614|Xanthomonadales	S	Putative sensor	-	-	-	-	-	-	-	-	-	-	-	-	Sensor
SHD2_k127_3494226_25	1163408.UU9_15110	3e-33	133.0	COG1695@1|root,COG1695@2|Bacteria,1NJSY@1224|Proteobacteria,1SG6R@1236|Gammaproteobacteria,1X6UG@135614|Xanthomonadales	135614|Xanthomonadales	K	PadR family transcriptional regulator	-	-	-	ko:K10947	-	-	-	-	ko00000,ko03000	-	-	-	PadR
SHD2_k127_3494226_17	1280952.HJA_16305	3.676e-72	252.0	COG2162@1|root,COG2162@2|Bacteria,1N2Q5@1224|Proteobacteria,2UQ5Z@28211|Alphaproteobacteria,43YWT@69657|Hyphomonadaceae	28211|Alphaproteobacteria	Q	Belongs to the arylamine N-acetyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_2
SHD2_k127_3494226_30	985867.AEWF01000013_gene2343	5.638e-06	57.0	2AMEA@1|root,31C9R@2|Bacteria,1Q8AJ@1224|Proteobacteria,2V780@28211|Alphaproteobacteria,47G69@766|Rickettsiales	766|Rickettsiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_3494226_5	78245.Xaut_2136	1.414e-163	524.0	COG4553@1|root,COG4553@2|Bacteria,1MVUH@1224|Proteobacteria,2TQXW@28211|Alphaproteobacteria,3EY0F@335928|Xanthobacteraceae	28211|Alphaproteobacteria	I	PHB de-polymerase C-terminus	MA20_01245	-	3.1.1.75	ko:K05973	ko00650,map00650	-	R05118	-	ko00000,ko00001,ko01000	-	-	-	PHB_depo_C
SHD2_k127_3494226_12	1380391.JIAS01000014_gene2328	4.054e-95	316.0	COG0625@1|root,COG0625@2|Bacteria,1NF66@1224|Proteobacteria,2TVE4@28211|Alphaproteobacteria,2JZI9@204441|Rhodospirillales	204441|Rhodospirillales	O	Glutathione S-transferase, N-terminal domain	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C_2,GST_N_3
SHD2_k127_3494226_2	228405.HNE_2022	5.467e-217	686.0	COG0318@1|root,COG0318@2|Bacteria,1QVGC@1224|Proteobacteria,2TWFC@28211|Alphaproteobacteria,43WY7@69657|Hyphomonadaceae	28211|Alphaproteobacteria	IQ	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II	-	-	2.3.1.40,6.2.1.20	ko:K05939	ko00071,ko00564,map00071,map00564	-	R01406,R04864	RC00014,RC00039,RC00041	ko00000,ko00001,ko01000	-	-	-	AMP-binding
SHD2_k127_3494226_6	402881.Plav_3136	1.372e-153	490.0	COG0320@1|root,COG0320@2|Bacteria,1MVRD@1224|Proteobacteria,2TRP3@28211|Alphaproteobacteria,1JN81@119043|Rhodobiaceae	28211|Alphaproteobacteria	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
SHD2_k127_3494226_23	698761.RTCIAT899_CH08645	9.976e-36	147.0	COG2867@1|root,COG2867@2|Bacteria,1RGUH@1224|Proteobacteria,2U7D8@28211|Alphaproteobacteria,4BE29@82115|Rhizobiaceae	28211|Alphaproteobacteria	I	oligoketide cyclase lipid transport protein	pasT	-	-	ko:K18588	-	-	-	-	ko00000	-	-	-	Polyketide_cyc
SHD2_k127_3494226_21	402881.Plav_3134	6.641e-64	222.0	COG1546@1|root,COG1546@2|Bacteria,1RH2Y@1224|Proteobacteria,2U94H@28211|Alphaproteobacteria,1JP93@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Competence-damaged protein	cinA	-	3.5.1.42	ko:K03743	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA
SHD2_k127_3494226_24	1122135.KB893167_gene2328	8.038e-35	142.0	COG1267@1|root,COG1267@2|Bacteria,1MZJA@1224|Proteobacteria,2UGK6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)	pgpA	-	3.1.3.27	ko:K01095	ko00564,ko01100,map00564,map01100	-	R02029	RC00017	ko00000,ko00001,ko01000	-	-	-	PgpA
SHD2_k127_3494226_29	1869.MB27_39095	1.896e-07	59.0	COG0454@1|root,COG0456@2|Bacteria,2IQC8@201174|Actinobacteria,4DEVT@85008|Micromonosporales	201174|Actinobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
SHD2_k127_3494226_8	414684.RC1_0126	3.1e-139	454.0	COG0245@1|root,COG1211@1|root,COG0245@2|Bacteria,COG1211@2|Bacteria,1MVHA@1224|Proteobacteria,2TRQC@28211|Alphaproteobacteria,2JPA7@204441|Rhodospirillales	204441|Rhodospirillales	I	Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF)	ispDF	-	2.7.7.60,4.6.1.12	ko:K12506	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633,R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD,YgbB
SHD2_k127_3494226_10	1101191.KI912577_gene3843	2.09e-131	429.0	COG3852@1|root,COG3852@2|Bacteria,1MVN6@1224|Proteobacteria,2TQS1@28211|Alphaproteobacteria,1JSGV@119045|Methylobacteriaceae	28211|Alphaproteobacteria	T	PFAM ATP-binding region ATPase domain protein	ntrB	-	2.7.13.3	ko:K07708	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_4
SHD2_k127_3494226_1	1038858.AXBA01000025_gene4977	5.534e-228	716.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2TQPG@28211|Alphaproteobacteria,3EY0I@335928|Xanthobacteraceae	28211|Alphaproteobacteria	T	AAA domain (Cdc48 subfamily)	ntrC	-	-	ko:K07712	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activ_2,Sigma54_activat
SHD2_k127_3494226_3	402881.Plav_3128	1.202e-200	649.0	COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,2TQTB@28211|Alphaproteobacteria,1JN1D@119043|Rhodobiaceae	28211|Alphaproteobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	ntrY	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.7.13.3	ko:K13598	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4
SHD2_k127_3494226_4	402881.Plav_3127	2.164e-196	622.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2TQW2@28211|Alphaproteobacteria,1JNQ5@119043|Rhodobiaceae	28211|Alphaproteobacteria	T	Sigma-54 interaction domain	ntrX	-	-	ko:K13599	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
SHD2_k127_3494226_14	1382303.JPOM01000001_gene1299	9.275e-93	316.0	COG0115@1|root,COG0115@2|Bacteria,1MVAT@1224|Proteobacteria,2TR7R@28211|Alphaproteobacteria,2KF88@204458|Caulobacterales	204458|Caulobacterales	EH	Catalyzes the transamination of D-amino acids and their alpha-keto acids	-	-	2.6.1.21	ko:K00824	ko00310,ko00330,ko00360,ko00472,ko00473,ko01100,map00310,map00330,map00360,map00472,map00473,map01100	-	R01148,R01582,R02459,R02851,R02924,R05053	RC00006,RC00008,RC00025	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_4
SHD2_k127_3494226_26	1234595.C725_0421	4.609e-33	129.0	COG1923@1|root,COG1923@2|Bacteria,1MZM1@1224|Proteobacteria,2UBTW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs	hfq	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0006807,GO:0008150,GO:0008152,GO:0009399,GO:0071941,GO:0097159,GO:1901363	-	ko:K03666	ko02024,ko03018,ko05111,map02024,map03018,map05111	-	-	-	ko00000,ko00001,ko03019,ko03036	-	-	-	Hfq
SHD2_k127_3494226_7	1168059.KB899087_gene992	8.214e-145	476.0	COG2262@1|root,COG2262@2|Bacteria,1MUA0@1224|Proteobacteria,2TUXJ@28211|Alphaproteobacteria,3EYA5@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0003924,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006417,GO:0006464,GO:0006468,GO:0006518,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006996,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016043,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018105,GO:0018193,GO:0018209,GO:0019001,GO:0019222,GO:0019538,GO:0019843,GO:0022411,GO:0030554,GO:0031323,GO:0031326,GO:0032268,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0032790,GO:0032984,GO:0032988,GO:0034248,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0036211,GO:0036289,GO:0043021,GO:0043022,GO:0043023,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051246,GO:0060255,GO:0065007,GO:0071704,GO:0071826,GO:0071840,GO:0072344,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008,GO:2000112	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
SHD2_k127_3494226_13	717785.HYPMC_4554	2.445e-94	317.0	COG2367@1|root,COG2367@2|Bacteria,1NMW4@1224|Proteobacteria,2TX7R@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	beta-lactamase	bla	-	3.5.2.6	ko:K17836	ko00311,ko01130,ko01501,map00311,map01130,map01501	M00627,M00628	R06363	RC01499	ko00000,ko00001,ko00002,ko01000,ko01504	-	-	-	Beta-lactamase2
SHD2_k127_3494226_15	1294273.roselon_02905	8.014e-87	294.0	COG1694@1|root,COG3956@2|Bacteria,1MVKM@1224|Proteobacteria,2TRC9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	TIGRFAM MazG family protein	mazG	GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009147,GO:0009149,GO:0009151,GO:0009155,GO:0009164,GO:0009166,GO:0009199,GO:0009200,GO:0009203,GO:0009204,GO:0009208,GO:0009210,GO:0009211,GO:0009213,GO:0009215,GO:0009217,GO:0009218,GO:0009219,GO:0009222,GO:0009223,GO:0009259,GO:0009261,GO:0009262,GO:0009264,GO:0009267,GO:0009394,GO:0009605,GO:0009987,GO:0009991,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0019693,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0042594,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046046,GO:0046047,GO:0046051,GO:0046052,GO:0046060,GO:0046061,GO:0046070,GO:0046075,GO:0046076,GO:0046080,GO:0046081,GO:0046131,GO:0046133,GO:0046135,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0050896,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658	3.6.1.9	ko:K02499,ko:K04765	ko00230,ko00240,ko00760,ko00770,ko01100,map00230,map00240,map00760,map00770,map01100	-	R00086,R00087,R00103,R00287,R00426,R00515,R00662,R00720,R03004,R03036,R11323	RC00002	ko00000,ko00001,ko01000,ko03036	-	-	-	MazG
SHD2_k127_3494226_27	1380387.JADM01000045_gene4165	3.474e-29	130.0	COG0346@1|root,COG0346@2|Bacteria,1RJZZ@1224|Proteobacteria,1S6PB@1236|Gammaproteobacteria,1XPV5@135619|Oceanospirillales	135619|Oceanospirillales	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
SHD2_k127_3494226_20	555793.WSK_2140	2.866e-67	242.0	COG0625@1|root,COG0625@2|Bacteria,1PPMN@1224|Proteobacteria,2V8HW@28211|Alphaproteobacteria,2KAKK@204457|Sphingomonadales	204457|Sphingomonadales	O	glutathione transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_3494226_22	639283.Snov_0696	1.022e-59	210.0	COG3677@1|root,COG3677@2|Bacteria,1MXYX@1224|Proteobacteria,2TQR3@28211|Alphaproteobacteria,3F1YX@335928|Xanthobacteraceae	28211|Alphaproteobacteria	L	ISXO2-like transposase domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS1595,Zn_Tnp_IS1595
SHD2_k127_3548065_26	59538.XP_005976332.1	1.089e-135	439.0	COG1028@1|root,KOG0725@2759|Eukaryota,38DZE@33154|Opisthokonta,3BA0D@33208|Metazoa,3CVGY@33213|Bilateria,480GA@7711|Chordata,49406@7742|Vertebrata,3JAEH@40674|Mammalia	33208|Metazoa	Q	oxidoreductase activity	hsdl2	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	SCP2,adh_short
SHD2_k127_3548065_24	69395.JQLZ01000006_gene2207	1.287e-137	446.0	COG0491@1|root,COG0491@2|Bacteria,1MUXF@1224|Proteobacteria,2TSYY@28211|Alphaproteobacteria,2KFGU@204458|Caulobacterales	204458|Caulobacterales	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
SHD2_k127_3548065_89	391165.GbCGDNIH1_2324	9.928e-44	169.0	COG2353@1|root,COG2353@2|Bacteria,1R9XD@1224|Proteobacteria,2TVD3@28211|Alphaproteobacteria,2JTHR@204441|Rhodospirillales	204441|Rhodospirillales	S	Belongs to the UPF0312 family	-	-	-	-	-	-	-	-	-	-	-	-	YceI
SHD2_k127_3548065_82	1333998.M2A_0577	5.26e-49	181.0	COG3038@1|root,COG3038@2|Bacteria,1MZ7X@1224|Proteobacteria,2UBYU@28211|Alphaproteobacteria,4BQQ1@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Prokaryotic cytochrome b561	yceJ	-	-	ko:K12262	-	-	-	-	ko00000	-	-	-	Ni_hydr_CYTB
SHD2_k127_3548065_97	395965.Msil_3201	6.222e-39	154.0	COG2353@1|root,COG2353@2|Bacteria,1RJFZ@1224|Proteobacteria,2UBXA@28211|Alphaproteobacteria,3NCH2@45404|Beijerinckiaceae	28211|Alphaproteobacteria	S	Belongs to the UPF0312 family	-	-	-	-	-	-	-	-	-	-	-	-	YceI
SHD2_k127_3548065_41	1207063.P24_05927	2.071e-105	351.0	COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,2TRIM@28211|Alphaproteobacteria,2JQ24@204441|Rhodospirillales	204441|Rhodospirillales	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine	-	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	SUA5,Sua5_yciO_yrdC
SHD2_k127_3548065_17	1333998.M2A_2612	6.982e-165	536.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2TRYI@28211|Alphaproteobacteria,4BPTY@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	FAD linked oxidases, C-terminal domain	MA20_42035	GO:0000166,GO:0003674,GO:0003824,GO:0004457,GO:0004458,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006082,GO:0006089,GO:0006091,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016053,GO:0016491,GO:0016614,GO:0016898,GO:0019249,GO:0019516,GO:0019752,GO:0022900,GO:0022904,GO:0030447,GO:0032787,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046394,GO:0048037,GO:0050660,GO:0050662,GO:0051990,GO:0055114,GO:0071704,GO:0071949,GO:0072330,GO:0097159,GO:0099615,GO:1901265,GO:1901363,GO:1901576,GO:1901615,GO:1901617	1.1.2.4	ko:K00102	ko00620,map00620	-	R00197	RC00044	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
SHD2_k127_3548065_10	95619.PM1_0217225	5.946e-220	711.0	COG1215@1|root,COG5309@1|root,COG1215@2|Bacteria,COG5309@2|Bacteria,1MWF8@1224|Proteobacteria,1S08E@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Pfam Glycosyl transferase family 2	bcsA	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_17,Glyco_tranf_2_3,Glyco_trans_2_3,Glycos_transf_2,PilZ
SHD2_k127_3548065_98	657309.BXY_20900	1.02e-38	151.0	COG0545@1|root,COG0545@2|Bacteria,4NDW4@976|Bacteroidetes,2FNCK@200643|Bacteroidia,4AMFU@815|Bacteroidaceae	976|Bacteroidetes	G	Peptidyl-prolyl cis-trans isomerase	fklB	-	5.2.1.8	ko:K03772,ko:K03773	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C,FKBP_N
SHD2_k127_3548065_36	402881.Plav_0764	3.026e-117	382.0	COG1028@1|root,COG1028@2|Bacteria,1MWGK@1224|Proteobacteria,2TVQ8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	MA20_16385	-	1.1.1.69	ko:K00046	-	-	-	-	ko00000,ko01000	-	-	-	adh_short_C2
SHD2_k127_3548065_92	94624.Bpet2949	1.185e-42	164.0	COG1309@1|root,COG1309@2|Bacteria,1MUUY@1224|Proteobacteria,2VWNC@28216|Betaproteobacteria	28216|Betaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N,WHG
SHD2_k127_3548065_107	331869.BAL199_20565	4.102e-32	133.0	COG5395@1|root,COG5395@2|Bacteria,1REYE@1224|Proteobacteria,2UB3Q@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Predicted membrane protein (DUF2306)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2306
SHD2_k127_3548065_12	1205680.CAKO01000004_gene3626	2.221e-177	567.0	COG0443@1|root,COG0443@2|Bacteria,1MXBT@1224|Proteobacteria,2TS1I@28211|Alphaproteobacteria,2JQWY@204441|Rhodospirillales	204441|Rhodospirillales	O	Belongs to the heat shock protein 70 family	-	-	-	ko:K04046	-	-	-	-	ko00000,ko03110	1.A.33	-	-	HSP70
SHD2_k127_3548065_23	402881.Plav_0758	1.653e-144	464.0	COG2070@1|root,COG2070@2|Bacteria,1MU2F@1224|Proteobacteria,2TUT7@28211|Alphaproteobacteria,1JNXV@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	PFAM 2-nitropropane dioxygenase NPD	-	-	1.13.12.16,1.3.1.9	ko:K00459,ko:K02371	ko00061,ko00910,ko01100,ko01212,map00061,map00910,map01100,map01212	M00083	R00025,R04429,R04724,R04955,R04958,R04961,R04966,R04969,R07765	RC00052,RC00076,RC02541,RC02759	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	NMO
SHD2_k127_3548065_88	1333998.M2A_2601	3.396e-45	173.0	COG1280@1|root,COG1280@2|Bacteria,1N227@1224|Proteobacteria,2UCZW@28211|Alphaproteobacteria,4BQWF@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	LysE type translocator	-	-	-	-	-	-	-	-	-	-	-	-	LysE
SHD2_k127_3548065_25	670292.JH26_07885	3.185e-137	443.0	COG0604@1|root,COG0604@2|Bacteria,1MV3W@1224|Proteobacteria,2TRW7@28211|Alphaproteobacteria,1JSP9@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	quinone oxidoreductase, YhdH YhfP family	MA20_42175	-	-	ko:K19745	ko00640,ko01100,map00640,map01100	-	R00919	RC00095	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
SHD2_k127_3548065_11	1411123.JQNH01000001_gene2309	1.146e-185	595.0	COG0044@1|root,COG0044@2|Bacteria,1MW10@1224|Proteobacteria,2TSQH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	F	COG0044 Dihydroorotase and related cyclic amidohydrolases	pyrC1	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
SHD2_k127_3548065_73	1411123.JQNH01000001_gene2310	8.417e-64	228.0	COG0354@1|root,COG0354@2|Bacteria,1N852@1224|Proteobacteria,2TR8J@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Belongs to the GcvT family	ygfZ	-	-	ko:K06980	-	-	-	-	ko00000,ko03016	-	-	-	GCV_T,GCV_T_C
SHD2_k127_3548065_93	1278073.MYSTI_07719	3.917e-42	160.0	COG0346@1|root,COG0346@2|Bacteria,1RH4D@1224|Proteobacteria	1224|Proteobacteria	E	Lactoylglutathione lyase and related lyases	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
SHD2_k127_3548065_67	1333998.M2A_3318	2.461e-73	256.0	COG2818@1|root,COG2818@2|Bacteria,1R9X5@1224|Proteobacteria,2TUP5@28211|Alphaproteobacteria,4BQE9@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	L	Methyladenine glycosylase	tag	-	3.2.2.20	ko:K01246	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Adenine_glyco
SHD2_k127_3548065_119	358681.BBR47_09430	3.083e-20	100.0	COG5628@1|root,COG5628@2|Bacteria,1VAGU@1239|Firmicutes,4HHK0@91061|Bacilli,26QQ8@186822|Paenibacillaceae	91061|Bacilli	S	Acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
SHD2_k127_3548065_65	717785.HYPMC_1959	1.887e-74	255.0	COG0780@1|root,COG0780@2|Bacteria,1MW0M@1224|Proteobacteria,2U57X@28211|Alphaproteobacteria,3N6RD@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)	queF	-	1.7.1.13	ko:K09457	ko00790,ko01100,map00790,map01100	-	R07605	RC01875	ko00000,ko00001,ko01000,ko03016	-	-	-	QueF
SHD2_k127_3548065_58	323097.Nham_0252	1.412e-78	271.0	COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,2TRRM@28211|Alphaproteobacteria,3JT0X@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	U	Belongs to the peptidase S26 family	MA20_19800	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
SHD2_k127_3548065_70	631454.N177_0336	3.289e-68	241.0	COG0431@1|root,COG0431@2|Bacteria,1MXQ8@1224|Proteobacteria,2TRI5@28211|Alphaproteobacteria,1JQ50@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
SHD2_k127_3548065_86	765698.Mesci_2215	1.925e-47	174.0	COG1733@1|root,COG1733@2|Bacteria,1MZ6N@1224|Proteobacteria,2UC19@28211|Alphaproteobacteria,43K6R@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
SHD2_k127_3548065_91	395963.Bind_2733	2.818e-43	160.0	COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,2U952@28211|Alphaproteobacteria,3NBBK@45404|Beijerinckiaceae	28211|Alphaproteobacteria	K	Belongs to the P(II) protein family	glnK	-	-	ko:K04751,ko:K04752	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
SHD2_k127_3548065_19	1002672.SAR11G3_00850	1.48e-156	503.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,2TT2J@28211|Alphaproteobacteria,4BP5Z@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	P	Ammonium Transporter Family	amtB	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
SHD2_k127_3548065_83	1038860.AXAP01000039_gene2554	5.716e-49	181.0	COG0712@1|root,COG0712@2|Bacteria,1MVRH@1224|Proteobacteria,2U5IC@28211|Alphaproteobacteria,3JSRB@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	-	-	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	OSCP
SHD2_k127_3548065_4	1382303.JPOM01000001_gene1275	1.246e-280	867.0	COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,2TQYK@28211|Alphaproteobacteria,2KG49@204458|Caulobacterales	204458|Caulobacterales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
SHD2_k127_3548065_37	1382303.JPOM01000001_gene1273	1.494e-115	378.0	COG0224@1|root,COG0224@2|Bacteria,1MU28@1224|Proteobacteria,2TR11@28211|Alphaproteobacteria,2KFFB@204458|Caulobacterales	204458|Caulobacterales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	-	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
SHD2_k127_3548065_6	1382303.JPOM01000001_gene1272	5.738e-266	824.0	COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,2TRGP@28211|Alphaproteobacteria,2KEYF@204458|Caulobacterales	204458|Caulobacterales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
SHD2_k127_3548065_102	1282876.BAOK01000002_gene466	1.413e-37	150.0	COG0355@1|root,COG0355@2|Bacteria,1RHE4@1224|Proteobacteria,2UBXX@28211|Alphaproteobacteria,4BQZW@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02113,ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE_N
SHD2_k127_3548065_52	402881.Plav_1467	5.758e-84	287.0	COG1633@1|root,COG1633@2|Bacteria,1R5XX@1224|Proteobacteria,2TTCD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)	-	-	-	-	-	-	-	-	-	-	-	-	FA_desaturase_2,Rubrerythrin
SHD2_k127_3548065_103	1161401.ASJA01000001_gene322	3.95e-37	147.0	COG0457@1|root,COG0457@2|Bacteria	1161401.ASJA01000001_gene322|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_3548065_28	1333998.M2A_0787	3.018e-134	432.0	COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,2TQYF@28211|Alphaproteobacteria,4BPBJ@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family	sdhB	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_10,Fer4_17,Fer4_8
SHD2_k127_3548065_29	402881.Plav_1321	4.217e-130	437.0	COG5360@1|root,COG5360@2|Bacteria,1MUJ4@1224|Proteobacteria,2TR5G@28211|Alphaproteobacteria,1JNA7@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Heparinase II/III-like protein	MA20_25080	-	-	-	-	-	-	-	-	-	-	-	Hepar_II_III
SHD2_k127_3548065_48	314225.ELI_12550	9.179e-96	317.0	COG0036@1|root,COG0036@2|Bacteria,1MUZM@1224|Proteobacteria,2TQKR@28211|Alphaproteobacteria,2K1ZB@204457|Sphingomonadales	204457|Sphingomonadales	G	Belongs to the ribulose-phosphate 3-epimerase family	rpe	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
SHD2_k127_3548065_74	1430440.MGMSRv2_0492	3.055e-63	237.0	28MIW@1|root,2ZAVI@2|Bacteria,1N523@1224|Proteobacteria,2TSDJ@28211|Alphaproteobacteria,2JS2D@204441|Rhodospirillales	204441|Rhodospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_3548065_105	1282876.BAOK01000002_gene429	5.268e-34	145.0	COG2009@1|root,COG2009@2|Bacteria,1N02N@1224|Proteobacteria,2UC47@28211|Alphaproteobacteria,4BQW9@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Succinate dehydrogenase Fumarate reductase	sdhC	-	-	ko:K00241	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
SHD2_k127_3548065_113	1123072.AUDH01000013_gene1447	9.725e-26	117.0	COG2142@1|root,COG2142@2|Bacteria,1MZND@1224|Proteobacteria,2UC3G@28211|Alphaproteobacteria,2JTFI@204441|Rhodospirillales	204441|Rhodospirillales	C	Succinate dehydrogenase, hydrophobic anchor subunit	sdhD	-	-	ko:K00242	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
SHD2_k127_3548065_1	402881.Plav_1435	1.991e-318	981.0	COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,2TQJA@28211|Alphaproteobacteria,1JNHJ@119043|Rhodobiaceae	28211|Alphaproteobacteria	C	Fumarate reductase flavoprotein C-term	sdhA	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
SHD2_k127_3548065_87	1254432.SCE1572_29015	2.737e-47	177.0	COG3837@1|root,COG3837@2|Bacteria,1R9WZ@1224|Proteobacteria,432KZ@68525|delta/epsilon subdivisions,2WYH1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
SHD2_k127_3548065_130	396595.TK90_0626	7.815e-06	54.0	COG4520@1|root,COG4520@2|Bacteria,1N0YF@1224|Proteobacteria,1SAAR@1236|Gammaproteobacteria,1X1DX@135613|Chromatiales	135613|Chromatiales	M	17 kDa outer membrane surface antigen	-	-	-	-	-	-	-	-	-	-	-	-	17kDa_Anti_2,Rick_17kDa_Anti
SHD2_k127_3548065_39	450851.PHZ_c1108	4.724e-111	364.0	COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,2TRIH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	MA20_16365	-	4.2.1.149	ko:K08299	-	-	R10675	RC01095	ko00000,ko01000	-	-	-	ECH_1
SHD2_k127_3548065_114	1282876.BAOK01000001_gene1615	1.405e-25	114.0	2E7JJ@1|root,3321R@2|Bacteria,1N9EY@1224|Proteobacteria,2UF3Z@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_3548065_71	1134912.AJTV01000055_gene3834	2.208e-64	226.0	COG0663@1|root,COG0663@2|Bacteria,1RD76@1224|Proteobacteria,2U5GR@28211|Alphaproteobacteria,36Y1N@31993|Methylocystaceae	28211|Alphaproteobacteria	S	Bacterial transferase hexapeptide (six repeats)	MA20_32230	-	-	-	-	-	-	-	-	-	-	-	Hexapep
SHD2_k127_3548065_90	864069.MicloDRAFT_00013410	2.059e-43	171.0	28Z9U@1|root,2ZM1P@2|Bacteria,1RBFF@1224|Proteobacteria,2U5YY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_3548065_47	1035191.HMPREF0185_01013	1.825e-97	329.0	COG1702@1|root,COG1702@2|Bacteria,1MWMU@1224|Proteobacteria,2TSYC@28211|Alphaproteobacteria,2KFPX@204458|Caulobacterales	204458|Caulobacterales	T	PFAM PhoH family protein	-	-	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
SHD2_k127_3548065_129	1333998.M2A_2558	3.61e-06	53.0	2DYTB@1|root,32V60@2|Bacteria,1PMJU@1224|Proteobacteria,2V06H@28211|Alphaproteobacteria,4BSYM@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_3548065_100	402881.Plav_2629	8.684e-38	152.0	2D6JA@1|root,32TME@2|Bacteria,1MXVJ@1224|Proteobacteria,2TQNP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_3548065_117	1282876.BAOK01000001_gene1604	3.564e-21	94.0	2E4B6@1|root,32Z6W@2|Bacteria,1N7QS@1224|Proteobacteria,2UFNH@28211|Alphaproteobacteria,4BR4U@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF3126)	MA20_32250	-	-	-	-	-	-	-	-	-	-	-	DUF3126
SHD2_k127_3548065_42	402881.Plav_2625	2.896e-104	357.0	COG0665@1|root,COG0665@2|Bacteria,1MVGP@1224|Proteobacteria,2TRX9@28211|Alphaproteobacteria,1JN2M@119043|Rhodobiaceae	28211|Alphaproteobacteria	E	FAD dependent oxidoreductase	ordL	-	-	ko:K09471	ko00330,ko01100,map00330,map01100	M00136	R07415	RC00062	ko00000,ko00001,ko00002,ko01000	-	-	-	DAO
SHD2_k127_3548065_40	402881.Plav_2624	7.937e-110	361.0	COG1045@1|root,COG1045@2|Bacteria,1MVFX@1224|Proteobacteria,2TQQ5@28211|Alphaproteobacteria,1JN9C@119043|Rhodobiaceae	28211|Alphaproteobacteria	E	Serine acetyltransferase, N-terminal	cysE	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009001,GO:0009058,GO:0009069,GO:0009070,GO:0009314,GO:0009333,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016053,GO:0016407,GO:0016412,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019344,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0050896,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,SATase_N
SHD2_k127_3548065_77	438753.AZC_0950	2.6e-60	214.0	COG0778@1|root,COG0778@2|Bacteria,1PKUV@1224|Proteobacteria,2U5MZ@28211|Alphaproteobacteria,3EZHJ@335928|Xanthobacteraceae	28211|Alphaproteobacteria	C	Nitroreductase family	MA20_31560	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
SHD2_k127_3548065_9	1333998.M2A_2572	1.962e-227	714.0	COG3119@1|root,COG3119@2|Bacteria,1MV0B@1224|Proteobacteria,2TT96@28211|Alphaproteobacteria,4BRVI@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	P	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
SHD2_k127_3548065_46	187272.Mlg_0017	1.476e-100	331.0	COG0602@1|root,COG0602@2|Bacteria,1MUJ2@1224|Proteobacteria,1RNQZ@1236|Gammaproteobacteria,1WWFN@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds	queE	-	4.3.99.3	ko:K10026	ko00790,ko01100,map00790,map01100	-	R10002	RC02989	ko00000,ko00001,ko01000,ko03016	-	-	-	Fer4_14,Radical_SAM
SHD2_k127_3548065_49	316058.RPB_2709	2.158e-95	317.0	COG0603@1|root,COG0603@2|Bacteria,1MU5V@1224|Proteobacteria,2TU7F@28211|Alphaproteobacteria,3JR5A@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	F	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))	queC	-	6.3.4.20	ko:K06920	ko00790,ko01100,map00790,map01100	-	R09978	RC00959	ko00000,ko00001,ko01000,ko03016	-	-	-	QueC
SHD2_k127_3548065_18	856793.MICA_879	1.629e-163	523.0	COG0332@1|root,COG0332@2|Bacteria,1MU9N@1224|Proteobacteria,2TU94@28211|Alphaproteobacteria,4BRDI@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	I	3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal	fabH_2	-	2.3.1.207	ko:K16872	-	-	-	-	ko00000,ko01000	-	-	-	ACP_syn_III,ACP_syn_III_C
SHD2_k127_3548065_56	1218075.BAYA01000006_gene2339	2.056e-79	273.0	COG0730@1|root,COG0730@2|Bacteria,1RCVI@1224|Proteobacteria,2WG87@28216|Betaproteobacteria,1K031@119060|Burkholderiaceae	28216|Betaproteobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
SHD2_k127_3548065_79	1282876.BAOK01000001_gene2854	5.528e-57	209.0	COG0589@1|root,COG0589@2|Bacteria,1QD8E@1224|Proteobacteria,2TVV1@28211|Alphaproteobacteria,4BTDV@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
SHD2_k127_3548065_66	1280949.HAD_15922	8.726e-74	253.0	COG1896@1|root,COG1896@2|Bacteria,1RACF@1224|Proteobacteria,2TUK3@28211|Alphaproteobacteria,43XDG@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	hydrolases of HD superfamily	MA20_42120	-	-	ko:K06952	-	-	-	-	ko00000	-	-	-	HD,HD_3
SHD2_k127_3548065_101	864069.MicloDRAFT_00068390	1.198e-37	147.0	COG5350@1|root,COG5350@2|Bacteria,1RDTX@1224|Proteobacteria,2U71X@28211|Alphaproteobacteria,1JUX7@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	protein tyrosine phosphatase	MA20_42125	-	-	-	-	-	-	-	-	-	-	-	DSPc,Y_phosphatase
SHD2_k127_3548065_33	402881.Plav_0736	2.796e-118	394.0	COG4111@1|root,COG4111@2|Bacteria,1MXHA@1224|Proteobacteria,2TQQU@28211|Alphaproteobacteria,1JNS9@119043|Rhodobiaceae	28211|Alphaproteobacteria	F	belongs to the nudix hydrolase family	MA20_42130	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_3548065_20	402881.Plav_0734	1.041e-153	492.0	COG0379@1|root,COG0379@2|Bacteria,1MWQU@1224|Proteobacteria,2TRPG@28211|Alphaproteobacteria,1JNHB@119043|Rhodobiaceae	28211|Alphaproteobacteria	H	Quinolinate synthetase A protein	nadA	-	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	-	NadA
SHD2_k127_3548065_14	1282876.BAOK01000001_gene2862	4.515e-172	554.0	COG0029@1|root,COG0029@2|Bacteria,1RBQW@1224|Proteobacteria,2TS0E@28211|Alphaproteobacteria,4BPWQ@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	nadB	-	1.4.3.16	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481	RC00006,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
SHD2_k127_3548065_45	1333998.M2A_1567	2.515e-101	339.0	COG0157@1|root,COG0157@2|Bacteria,1MW0C@1224|Proteobacteria,2TS7C@28211|Alphaproteobacteria,4BPUR@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	H	Quinolinate phosphoribosyl transferase, C-terminal domain	nadC	-	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	-	QRPTase_C,QRPTase_N
SHD2_k127_3548065_34	1304878.AUGD01000006_gene6710	8.977e-118	383.0	COG1028@1|root,COG1028@2|Bacteria,1MW46@1224|Proteobacteria,2TUTU@28211|Alphaproteobacteria,3JVSJ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IQ	KR domain	MA20_15935	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
SHD2_k127_3548065_110	595536.ADVE02000001_gene3707	8.147e-29	124.0	COG3773@1|root,COG3773@2|Bacteria,1MWX3@1224|Proteobacteria,2TT15@28211|Alphaproteobacteria,36YF2@31993|Methylocystaceae	28211|Alphaproteobacteria	M	Cell Wall Hydrolase	sleB	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_2
SHD2_k127_3548065_0	1131814.JAFO01000001_gene3823	0.0	1199.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,2TR3C@28211|Alphaproteobacteria,3EY8V@335928|Xanthobacteraceae	28211|Alphaproteobacteria	G	Pyruvate phosphate dikinase, PEP/pyruvate binding domain	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
SHD2_k127_3548065_104	1538295.JY96_10500	6.993e-35	138.0	COG5331@1|root,COG5331@2|Bacteria,1Q52X@1224|Proteobacteria,2VY63@28216|Betaproteobacteria	28216|Betaproteobacteria	S	MAPEG family	-	-	-	-	-	-	-	-	-	-	-	-	MAPEG
SHD2_k127_3548065_8	1336243.JAEA01000003_gene2233	2.575e-238	759.0	COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,2TQKJ@28211|Alphaproteobacteria,1JS9W@119045|Methylobacteriaceae	28211|Alphaproteobacteria	J	Glycyl-tRNA synthetase beta subunit	glyS	-	6.1.1.14	ko:K01879	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_1,tRNA_synt_2f
SHD2_k127_3548065_21	1238182.C882_0505	7.197e-153	486.0	COG0752@1|root,COG0752@2|Bacteria,1MVCJ@1224|Proteobacteria,2TS2N@28211|Alphaproteobacteria,2JPFQ@204441|Rhodospirillales	204441|Rhodospirillales	J	glycyl-tRNA synthetase, alpha subunit	glyQ	-	6.1.1.14	ko:K01878	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2e
SHD2_k127_3548065_53	1122604.JONR01000011_gene3738	1.043e-83	289.0	COG3391@1|root,COG3391@2|Bacteria,1RFSR@1224|Proteobacteria,1SJKQ@1236|Gammaproteobacteria,1XCFR@135614|Xanthomonadales	135614|Xanthomonadales	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_3548065_57	666684.AfiDRAFT_1569	4.46e-79	271.0	2905E@1|root,2ZMVA@2|Bacteria,1REVI@1224|Proteobacteria,2UAXB@28211|Alphaproteobacteria,3K3KX@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Putative MetA-pathway of phenol degradation	-	-	-	-	-	-	-	-	-	-	-	-	Phenol_MetA_deg
SHD2_k127_3548065_50	402881.Plav_0215	1.424e-90	300.0	COG0346@1|root,COG0346@2|Bacteria,1MWHG@1224|Proteobacteria,2U1WR@28211|Alphaproteobacteria,1JQ5U@119043|Rhodobiaceae	28211|Alphaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	MA20_09990	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase_4
SHD2_k127_3548065_84	402881.Plav_0724	9.581e-48	192.0	COG4123@1|root,COG4123@2|Bacteria,1MXEQ@1224|Proteobacteria,2TUBR@28211|Alphaproteobacteria,1JPAZ@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Methyltransferase small domain	yfiC	-	2.1.1.223	ko:K15460	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	MTS
SHD2_k127_3548065_121	394.NGR_c04590	1.996e-12	80.0	2E3KZ@1|root,32YJ8@2|Bacteria,1N7A7@1224|Proteobacteria,2UFMR@28211|Alphaproteobacteria,4BG6V@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Putative prokaryotic signal transducing protein	MA20_42240	-	-	-	-	-	-	-	-	-	-	-	DUF2007
SHD2_k127_3548065_38	1282876.BAOK01000001_gene2877	7.344e-113	374.0	COG0142@1|root,COG0142@2|Bacteria,1MUK6@1224|Proteobacteria,2TSDZ@28211|Alphaproteobacteria,4BPY2@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	H	Belongs to the FPP GGPP synthase family	ispB	GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009108,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0042180,GO:0042181,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901615,GO:1901617,GO:1901661,GO:1901663	2.5.1.90	ko:K02523	ko00900,ko01110,map00900,map01110	-	R09248	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
SHD2_k127_3548065_68	391616.OA238_c37810	2.237e-72	258.0	COG1947@1|root,COG1947@2|Bacteria,1MVU3@1224|Proteobacteria,2TUFV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	F	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	ispE	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0050515	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
SHD2_k127_3548065_31	1333998.M2A_1555	2.381e-128	429.0	COG0457@1|root,COG0457@2|Bacteria,1MYB8@1224|Proteobacteria,2TQV5@28211|Alphaproteobacteria,4BPX9@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Tetratricopeptide repeats	MA20_42300	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_2,TPR_6,TPR_7,TPR_8
SHD2_k127_3548065_7	1211115.ALIQ01000052_gene2838	1.159e-251	786.0	COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,1MVU6@1224|Proteobacteria,2TS0R@28211|Alphaproteobacteria,3NA0S@45404|Beijerinckiaceae	28211|Alphaproteobacteria	C	Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S	-	-	1.5.5.1	ko:K00311	-	-	-	-	ko00000,ko01000	-	-	-	ETF_QO,FAD_binding_2,NAD_binding_8
SHD2_k127_3548065_60	402881.Plav_0718	3.454e-77	267.0	COG1573@1|root,COG1573@2|Bacteria,1MWX1@1224|Proteobacteria,2TT4Q@28211|Alphaproteobacteria,1JNSE@119043|Rhodobiaceae	28211|Alphaproteobacteria	L	Uracil DNA glycosylase superfamily	udgA	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
SHD2_k127_3548065_43	402881.Plav_0717	3.14e-104	362.0	COG0741@1|root,COG0741@2|Bacteria,1MV3F@1224|Proteobacteria,2U35U@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains)	-	-	-	-	-	-	-	-	-	-	-	-	SLT
SHD2_k127_3548065_59	1333998.M2A_1551	8.636e-78	266.0	COG0521@1|root,COG0521@2|Bacteria,1R9W2@1224|Proteobacteria,2TTA8@28211|Alphaproteobacteria,4BQ70@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	H	May be involved in the biosynthesis of molybdopterin	moaB	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0042802,GO:0044424,GO:0044444,GO:0044464	2.7.7.75	ko:K03638	ko00790,ko01100,map00790,map01100	-	R09726	RC00002	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth
SHD2_k127_3548065_62	935261.JAGL01000016_gene2769	9.979e-76	268.0	COG4447@1|root,COG4447@2|Bacteria,1ND1J@1224|Proteobacteria,2U0UY@28211|Alphaproteobacteria,43IAS@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	protein related to plant photosystem II stability assembly factor	-	-	-	-	-	-	-	-	-	-	-	-	BNR,Sortilin-Vps10
SHD2_k127_3548065_122	1127134.NOCYR_3065	4.425e-11	67.0	COG1977@1|root,COG1977@2|Bacteria,2GQM9@201174|Actinobacteria,4G3HC@85025|Nocardiaceae	201174|Actinobacteria	H	ThiS family	-	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
SHD2_k127_3548065_106	1280954.HPO_17993	5.759e-34	134.0	COG3631@1|root,COG3631@2|Bacteria,1NF7U@1224|Proteobacteria,2UH89@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
SHD2_k127_3548065_85	215803.DB30_6462	1.822e-47	173.0	COG0640@1|root,COG0640@2|Bacteria,1RH5P@1224|Proteobacteria,430Y1@68525|delta/epsilon subdivisions,2WVU4@28221|Deltaproteobacteria,2YVFD@29|Myxococcales	28221|Deltaproteobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
SHD2_k127_3548065_80	1197906.CAJQ02000051_gene41	2.488e-55	199.0	COG3832@1|root,COG3832@2|Bacteria,1NBW5@1224|Proteobacteria	1224|Proteobacteria	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
SHD2_k127_3548065_94	402626.Rpic_0858	9.025e-40	155.0	COG3812@1|root,COG3812@2|Bacteria,1RGUV@1224|Proteobacteria,2VS54@28216|Betaproteobacteria,1K3QS@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Domain of unknown function (DUF1993)	-	-	-	ko:K09983	-	-	-	-	ko00000	-	-	-	DUF1993
SHD2_k127_3548065_81	1333998.M2A_1548	1.804e-53	198.0	COG1215@1|root,COG1215@2|Bacteria,1RA75@1224|Proteobacteria,2TXAA@28211|Alphaproteobacteria,4BS6A@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glycos_transf_2
SHD2_k127_3548065_78	290397.Adeh_2250	5.13e-59	218.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	sigM	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2,SnoaL_2
SHD2_k127_3548065_75	247633.GP2143_10007	9.716e-62	230.0	COG5285@1|root,COG5285@2|Bacteria	2|Bacteria	Q	dioxygenase activity	phyH	-	-	-	-	-	-	-	-	-	-	-	PhyH
SHD2_k127_3548065_127	1123054.KB907711_gene400	1.425e-06	55.0	2EPXY@1|root,33HIG@2|Bacteria,1NK7K@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_3548065_118	366602.Caul_3519	7.266e-21	93.0	COG1476@1|root,COG1476@2|Bacteria,1N7BB@1224|Proteobacteria,2UGNF@28211|Alphaproteobacteria,2KJC1@204458|Caulobacterales	204458|Caulobacterales	K	Helix-turn-helix XRE-family like proteins	-	-	-	ko:K07729	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3
SHD2_k127_3548065_22	1297865.APJD01000007_gene1968	3.645e-150	484.0	COG1533@1|root,COG1533@2|Bacteria,1MW0H@1224|Proteobacteria,2TQQB@28211|Alphaproteobacteria,3JSMU@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Elongator protein 3, MiaB family, Radical SAM	MA20_42330	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
SHD2_k127_3548065_128	1122603.ATVI01000005_gene3255	3.514e-06	54.0	2EIJE@1|root,33CAQ@2|Bacteria,1PVJ0@1224|Proteobacteria,1RWAX@1236|Gammaproteobacteria,1XBGS@135614|Xanthomonadales	135614|Xanthomonadales	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_3548065_99	1123261.AXDW01000005_gene2550	7.836e-38	148.0	COG1595@1|root,COG1595@2|Bacteria,1RD9G@1224|Proteobacteria,1S82R@1236|Gammaproteobacteria,1X7PT@135614|Xanthomonadales	135614|Xanthomonadales	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
SHD2_k127_3548065_72	595536.ADVE02000001_gene2863	2.824e-64	226.0	COG0164@1|root,COG0164@2|Bacteria,1RA65@1224|Proteobacteria,2U73X@28211|Alphaproteobacteria,36YDE@31993|Methylocystaceae	28211|Alphaproteobacteria	L	Ribonuclease HII	rnhB	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
SHD2_k127_3548065_15	1402135.SUH3_10825	8.105e-172	546.0	COG2189@1|root,COG2189@2|Bacteria,1MX9M@1224|Proteobacteria,2TSW9@28211|Alphaproteobacteria,3ZWV5@60136|Sulfitobacter	28211|Alphaproteobacteria	L	Belongs to the N(4) N(6)-methyltransferase family	ccrM	-	2.1.1.72	ko:K13581	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko02048	-	-	-	N6_N4_Mtase
SHD2_k127_3548065_32	414684.RC1_0510	1.066e-119	397.0	COG1194@1|root,COG1194@2|Bacteria,1MUD4@1224|Proteobacteria,2TQVX@28211|Alphaproteobacteria,2JPDG@204441|Rhodospirillales	204441|Rhodospirillales	L	COG1194 A G-specific DNA glycosylase	mutY	-	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD,NUDIX_4
SHD2_k127_3548065_123	555217.Zmob_1465	8.311e-11	69.0	COG5389@1|root,COG5389@2|Bacteria,1N82D@1224|Proteobacteria,2UFA9@28211|Alphaproteobacteria,2K4U1@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function (DUF721)	-	-	-	-	-	-	-	-	-	-	-	-	DUF721
SHD2_k127_3548065_96	1370122.JHXQ01000005_gene3251	3.708e-39	155.0	COG1651@1|root,COG1651@2|Bacteria,1RFF4@1224|Proteobacteria,2U5BN@28211|Alphaproteobacteria,4B74W@82115|Rhizobiaceae	28211|Alphaproteobacteria	O	COG1651 Protein-disulfide isomerase	MA20_42440	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_4
SHD2_k127_3548065_2	1282876.BAOK01000001_gene2895	3.85e-314	999.0	COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,2TRQG@28211|Alphaproteobacteria,4BPS7@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N
SHD2_k127_3548065_124	318586.Pden_2880	4.084e-10	66.0	COG5336@1|root,COG5336@2|Bacteria,1PSBP@1224|Proteobacteria,2V4IM@28211|Alphaproteobacteria,2PX51@265|Paracoccus	28211|Alphaproteobacteria	S	function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex	-	-	-	ko:K02116	-	-	-	-	ko00000,ko00194	3.A.2.1	-	-	ATPase_gene1
SHD2_k127_3548065_55	631454.N177_1080	7.642e-82	280.0	COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,2TRNV@28211|Alphaproteobacteria,1JN2A@119043|Rhodobiaceae	28211|Alphaproteobacteria	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
SHD2_k127_3548065_111	717785.HYPMC_4164	1.433e-27	113.0	COG0636@1|root,COG0636@2|Bacteria,1MZBU@1224|Proteobacteria,2UFPN@28211|Alphaproteobacteria,3N77Z@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpE	-	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_C
SHD2_k127_3548065_115	420324.KI911934_gene204	1.233e-23	107.0	COG0711@1|root,COG0711@2|Bacteria,1MZGU@1224|Proteobacteria,2UBVW@28211|Alphaproteobacteria,1JTTR@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)	atpF2	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
SHD2_k127_3548065_108	1282876.BAOK01000001_gene2900	2.076e-30	126.0	COG0711@1|root,COG0711@2|Bacteria,1N0P5@1224|Proteobacteria,2U5DD@28211|Alphaproteobacteria,4BQVR@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	atpF	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
SHD2_k127_3548065_131	118166.JH976538_gene5412	1.419e-05	54.0	2DNU1@1|root,32Z4S@2|Bacteria	2|Bacteria	S	SpoIIAA-like	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIAA-like
SHD2_k127_3548065_3	743836.AYNA01000028_gene2412	7.253e-284	885.0	COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,2TR9U@28211|Alphaproteobacteria,36XU8@31993|Methylocystaceae	28211|Alphaproteobacteria	J	GAD domain	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
SHD2_k127_3548065_30	1333998.M2A_1153	4.116e-129	426.0	COG0349@1|root,COG0349@2|Bacteria,1MURV@1224|Proteobacteria,2TSQM@28211|Alphaproteobacteria,4BP99@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	J	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides	rnd	-	3.1.13.5	ko:K03684	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DNA_pol_A_exo1,HRDC
SHD2_k127_3548065_61	883080.HMPREF9697_00640	4.585e-77	266.0	COG1386@1|root,COG1386@2|Bacteria,1PUA6@1224|Proteobacteria,2TU64@28211|Alphaproteobacteria,3JUGS@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves	scpB	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
SHD2_k127_3548065_63	1333998.M2A_0495	2.435e-75	264.0	COG1354@1|root,COG1354@2|Bacteria,1MVCN@1224|Proteobacteria,2TS1V@28211|Alphaproteobacteria,4BQ7E@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	scpA	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
SHD2_k127_3548065_35	258594.RPA2852	1.453e-117	387.0	COG1472@1|root,COG1472@2|Bacteria,1MVAJ@1224|Proteobacteria,2TRJK@28211|Alphaproteobacteria,3JRM6@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Glycosyl hydrolase family 3 N terminal domain	nagZ	-	3.2.1.21,3.2.1.52	ko:K01207,ko:K05349	ko00460,ko00500,ko00520,ko00531,ko00940,ko01100,ko01110,ko01501,map00460,map00500,map00520,map00531,map00940,map01100,map01110,map01501	M00628	R00022,R00026,R02558,R02887,R02985,R03527,R04949,R04998,R05963,R07809,R07810,R10035,R10039,R10040,R10831	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko00002,ko01000	-	GH3	-	Glyco_hydro_3
SHD2_k127_3548065_112	1333998.M2A_0497	1.921e-26	120.0	COG3087@1|root,COG3087@2|Bacteria,1QW4V@1224|Proteobacteria,2TXJ8@28211|Alphaproteobacteria,4BSHG@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	D	Sporulation related domain	-	-	-	-	-	-	-	-	-	-	-	-	SPOR
SHD2_k127_3548065_27	1380391.JIAS01000011_gene5352	2.377e-134	445.0	COG0232@1|root,COG0232@2|Bacteria,1MVQ2@1224|Proteobacteria,2TRCD@28211|Alphaproteobacteria,2JQG9@204441|Rhodospirillales	204441|Rhodospirillales	F	deoxyguanosinetriphosphate triphosphohydrolase-like protein	-	-	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	-	HD,HD_assoc
SHD2_k127_3548065_95	709797.CSIRO_2826	1.315e-39	150.0	COG0316@1|root,COG0316@2|Bacteria,1RHCW@1224|Proteobacteria,2UBR8@28211|Alphaproteobacteria,3JZKF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Belongs to the HesB IscA family	erpA	-	-	ko:K13628,ko:K15724	-	-	-	-	ko00000,ko03016	-	-	-	Fe-S_biosyn
SHD2_k127_3548065_44	663610.JQKO01000011_gene3354	1.094e-103	343.0	COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,2TR5J@28211|Alphaproteobacteria,3N9QQ@45404|Beijerinckiaceae	28211|Alphaproteobacteria	L	Endonuclease/Exonuclease/phosphatase family	xth	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
SHD2_k127_3548065_109	1434929.X946_1621	2.769e-30	124.0	COG3791@1|root,COG3791@2|Bacteria,1N6S5@1224|Proteobacteria,2VWNN@28216|Betaproteobacteria,1K87H@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Glutathione-dependent formaldehyde-activating enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GFA
SHD2_k127_3548065_54	1333998.M2A_0439	2.305e-83	284.0	COG0406@1|root,COG0406@2|Bacteria,1R62X@1224|Proteobacteria,2U6T9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Phosphoglycerate mutase	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
SHD2_k127_3548065_16	402881.Plav_3088	1.495e-169	541.0	COG1804@1|root,COG1804@2|Bacteria,1MW1H@1224|Proteobacteria,2TR7D@28211|Alphaproteobacteria,1JN9E@119043|Rhodobiaceae	28211|Alphaproteobacteria	C	CoA-transferase family III	MA20_39420	-	5.1.99.4	ko:K01796	ko00120,ko01100,ko04146,map00120,map01100,map04146	M00104	R08734,R08739	RC02345	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_transf_3
SHD2_k127_3548065_69	631454.N177_0802	3.271e-71	246.0	COG2761@1|root,COG2761@2|Bacteria,1NXUB@1224|Proteobacteria,2TRJ6@28211|Alphaproteobacteria,1JNY8@119043|Rhodobiaceae	28211|Alphaproteobacteria	Q	DSBA-like thioredoxin domain	dsb	-	-	-	-	-	-	-	-	-	-	-	DSBA
SHD2_k127_3548065_51	1333998.M2A_0443	6.387e-88	297.0	COG1028@1|root,COG1028@2|Bacteria,1MXWI@1224|Proteobacteria,2TQQ6@28211|Alphaproteobacteria,4BT7T@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
SHD2_k127_3548065_5	1429916.X566_13560	3.837e-278	867.0	COG2072@1|root,COG2072@2|Bacteria,1NSY9@1224|Proteobacteria,2TUSD@28211|Alphaproteobacteria,3JUMD@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Flavin-binding monooxygenase-like	-	-	1.14.13.22	ko:K03379	ko00930,ko01120,ko01220,map00930,map01120,map01220	-	R02231,R06622	RC00662,RC01550	ko00000,ko00001,ko01000	-	-	-	-
SHD2_k127_3548065_120	633131.TR2A62_1039	2.967e-13	76.0	COG1664@1|root,COG1664@2|Bacteria,1MZN0@1224|Proteobacteria,2U5DW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Integral membrane protein CcmA involved in cell shape determination	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
SHD2_k127_3548065_116	1150469.RSPPHO_02923	1.214e-21	101.0	COG1664@1|root,COG1664@2|Bacteria,1MZN0@1224|Proteobacteria,2U5DW@28211|Alphaproteobacteria,2JT69@204441|Rhodospirillales	204441|Rhodospirillales	M	Integral membrane protein CcmA involved in cell shape determination	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
SHD2_k127_3548065_64	318996.AXAZ01000016_gene3579	7.825e-75	253.0	COG3791@1|root,COG3791@2|Bacteria,1RCYS@1224|Proteobacteria,2U5UG@28211|Alphaproteobacteria,3JUX3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Glutathione-dependent formaldehyde-activating enzyme	MA20_19505	-	-	-	-	-	-	-	-	-	-	-	GFA
SHD2_k127_3548065_13	402881.Plav_2815	1.669e-176	563.0	COG0745@1|root,COG2199@1|root,COG0745@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,2TQQM@28211|Alphaproteobacteria,1JNCR@119043|Rhodobiaceae	28211|Alphaproteobacteria	T	diguanylate cyclase	pleD	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0042802,GO:0044424,GO:0044464	2.7.7.65	ko:K02488	ko02020,ko04112,map02020,map04112	M00511	R08057	-	ko00000,ko00001,ko00002,ko01000,ko02022	-	-	-	GGDEF,Response_reg
SHD2_k127_3548065_76	402881.Plav_2814	2.196e-61	220.0	COG0745@1|root,COG0745@2|Bacteria,1RD7E@1224|Proteobacteria,2U745@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Response regulator receiver	divK	-	-	ko:K11443	ko02020,ko04112,map02020,map04112	M00511	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg
SHD2_k127_3548065_125	246200.SPO2752	5.498e-10	63.0	2DMKE@1|root,32S6E@2|Bacteria,1N0IU@1224|Proteobacteria,2UC7Q@28211|Alphaproteobacteria,4NCKW@97050|Ruegeria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF3572)	MA20_36230	-	-	-	-	-	-	-	-	-	-	-	DUF3572
SHD2_k127_3548065_126	1333998.M2A_2854	1.197e-07	55.0	COG0647@1|root,COG0647@2|Bacteria,1RFSZ@1224|Proteobacteria,2U7SF@28211|Alphaproteobacteria,4BSRX@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	G	UMP catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_3775756_8	663610.JQKO01000009_gene486	5.954e-41	157.0	COG3038@1|root,COG3038@2|Bacteria,1RDR3@1224|Proteobacteria,2VG81@28211|Alphaproteobacteria,3NBFW@45404|Beijerinckiaceae	28211|Alphaproteobacteria	C	Prokaryotic cytochrome b561	-	-	-	ko:K12262	-	-	-	-	ko00000	-	-	-	Ni_hydr_CYTB
SHD2_k127_3775756_3	420324.KI912045_gene4535	5.729e-128	424.0	COG2124@1|root,COG2124@2|Bacteria,1MV75@1224|Proteobacteria,2TSV7@28211|Alphaproteobacteria,1JREF@119045|Methylobacteriaceae	28211|Alphaproteobacteria	Q	PFAM Cytochrome P450	p450	-	-	-	-	-	-	-	-	-	-	-	p450
SHD2_k127_3775756_7	402881.Plav_2446	1.357e-44	168.0	COG3814@1|root,COG3814@2|Bacteria,1N1FE@1224|Proteobacteria,2U7H9@28211|Alphaproteobacteria,1JP24@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Stringent starvation protein B	MA20_02250	-	-	ko:K09985	-	-	-	-	ko00000	-	-	-	SspB
SHD2_k127_3775756_0	935261.JAGL01000017_gene2696	1.037e-257	798.0	COG0114@1|root,COG0114@2|Bacteria,1MUQI@1224|Proteobacteria,2TQM7@28211|Alphaproteobacteria,43HHY@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate	fumC	-	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
SHD2_k127_3775756_5	318586.Pden_2561	2.687e-84	292.0	COG0697@1|root,COG0697@2|Bacteria,1MZQM@1224|Proteobacteria,2TUPG@28211|Alphaproteobacteria,2PWUQ@265|Paracoccus	28211|Alphaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
SHD2_k127_3775756_9	509190.Cseg_1455	4.233e-14	79.0	COG4321@1|root,COG4321@2|Bacteria,1PV4X@1224|Proteobacteria,2V6KV@28211|Alphaproteobacteria,2KH7E@204458|Caulobacterales	204458|Caulobacterales	S	Ribbon-helix-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	RHH_4
SHD2_k127_3775756_6	59538.XP_005961803.1	1.308e-49	183.0	COG0625@1|root,KOG0867@2759|Eukaryota	2759|Eukaryota	O	Belongs to the GST superfamily	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_2,GST_N,GST_N_3
SHD2_k127_3775756_4	1122612.AUBA01000010_gene55	4.778e-103	349.0	COG0025@1|root,COG0025@2|Bacteria,1MW5T@1224|Proteobacteria,2TQME@28211|Alphaproteobacteria,2K1QP@204457|Sphingomonadales	204457|Sphingomonadales	P	Sodium/hydrogen exchanger family	-	-	-	ko:K03316	-	-	-	-	ko00000	2.A.36	-	-	Na_H_Exchanger
SHD2_k127_3775756_2	1282876.BAOK01000001_gene1382	3.249e-150	485.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TR7Q@28211|Alphaproteobacteria,4BPJW@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	acyl-CoA transferases carnitine dehydratase	-	-	2.8.3.19	ko:K18702	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
SHD2_k127_3775756_1	1333998.M2A_1363	4.608e-154	495.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,2TS2B@28211|Alphaproteobacteria,4BP64@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	L	UvrD-like helicase C-terminal domain	uvrD	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
SHD2_k127_3999640_2	1333507.AUTQ01000018_gene1649	1.109e-21	98.0	COG3861@1|root,COG3861@2|Bacteria,1RD6Y@1224|Proteobacteria,1S4FS@1236|Gammaproteobacteria,2Q4PH@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	PRC
SHD2_k127_3999640_1	1266925.JHVX01000001_gene2477	6.077e-32	125.0	2DP0W@1|root,3302Q@2|Bacteria,1N8JI@1224|Proteobacteria,2VWC3@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein of unknown function (DUF2945)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2945
SHD2_k127_3999640_0	663610.JQKO01000009_gene477	1.391e-219	692.0	COG0446@1|root,COG2146@1|root,COG0446@2|Bacteria,COG2146@2|Bacteria,1NR3M@1224|Proteobacteria,2TS0K@28211|Alphaproteobacteria,3NAVA@45404|Beijerinckiaceae	28211|Alphaproteobacteria	P	Reductase C-terminal	-	-	1.18.1.1	ko:K05297	ko00071,map00071	-	R02000	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim,Reductase_C,Rieske
SHD2_k127_4006152_0	1333998.M2A_2536	5.369e-76	259.0	COG3917@1|root,COG3917@2|Bacteria,1RDNQ@1224|Proteobacteria,2VGB4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	2-hydroxychromene-2-carboxylate isomerase	MA20_32385	-	-	-	-	-	-	-	-	-	-	-	DSBA
SHD2_k127_4006152_1	1282876.BAOK01000001_gene1632	1.129e-39	156.0	COG0705@1|root,COG0705@2|Bacteria,1MYFP@1224|Proteobacteria,2TSJG@28211|Alphaproteobacteria,4BS86@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Rhomboid family	MA20_31620	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
SHD2_k127_4229866_2	1449049.JONW01000005_gene1369	1.085e-88	299.0	COG1028@1|root,COG1028@2|Bacteria,1RF8S@1224|Proteobacteria,2TWEU@28211|Alphaproteobacteria,2KI9R@204458|Caulobacterales	204458|Caulobacterales	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
SHD2_k127_4229866_1	1230476.C207_06093	2.29e-206	647.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TQQ7@28211|Alphaproteobacteria,3JR1V@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Belongs to the thiolase family	MA20_05130	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
SHD2_k127_4229866_0	1116472.MGMO_96c00130	0.0	1069.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,1XEV2@135618|Methylococcales	135618|Methylococcales	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
SHD2_k127_4229866_3	118166.JH976537_gene2732	6.14e-26	109.0	28KEA@1|root,2ZA0J@2|Bacteria	2|Bacteria	H	Sulfotransferase	-	-	2.8.2.1	ko:K01014	ko05204,map05204	-	R01242	RC00007,RC00128	ko00000,ko00001,ko01000	-	-	-	Sulfotransfer_1
SHD2_k127_4248927_1	420662.Mpe_A2086	0.0006472	48.0	COG2041@1|root,COG2041@2|Bacteria,1MX9E@1224|Proteobacteria,2VI1T@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Molybdopterin binding	-	-	-	ko:K17225	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	Mo-co_dimer,Oxidored_molyb
SHD2_k127_4248927_0	675635.Psed_4244	6.607e-107	351.0	COG1073@1|root,COG1073@2|Bacteria	2|Bacteria	S	thiolester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
SHD2_k127_4249803_14	1163617.SCD_n00015	8.141e-132	430.0	COG3158@1|root,COG3158@2|Bacteria,1MUVH@1224|Proteobacteria,2VH9I@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Transport of potassium into the cell	kup	-	-	ko:K03549	-	-	-	-	ko00000,ko02000	2.A.72	-	-	K_trans
SHD2_k127_4249803_7	1123354.AUDR01000013_gene687	3.764e-197	634.0	COG3158@1|root,COG3158@2|Bacteria,1MUVH@1224|Proteobacteria,2VH9I@28216|Betaproteobacteria,1KRD5@119069|Hydrogenophilales	119069|Hydrogenophilales	P	K+ potassium transporter	-	-	-	-	-	-	-	-	-	-	-	-	K_trans
SHD2_k127_4249803_36	1123072.AUDH01000022_gene1076	7.613e-36	145.0	COG3942@1|root,COG3942@2|Bacteria,1N0K8@1224|Proteobacteria,2UDGN@28211|Alphaproteobacteria,2JT7P@204441|Rhodospirillales	204441|Rhodospirillales	S	CHAP domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAP
SHD2_k127_4249803_20	765914.ThisiDRAFT_0338	4.928e-107	364.0	COG1215@1|root,COG1215@2|Bacteria,1MWF8@1224|Proteobacteria,1RPJ6@1236|Gammaproteobacteria,1WWHN@135613|Chromatiales	135613|Chromatiales	M	glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3
SHD2_k127_4249803_35	1122612.AUBA01000001_gene1298	9.306e-46	176.0	COG3735@1|root,COG3735@2|Bacteria,1MVCW@1224|Proteobacteria,2U5RA@28211|Alphaproteobacteria,2JZWN@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	ko:K09973	-	-	-	-	ko00000	-	-	-	TraB
SHD2_k127_4249803_11	414684.RC1_2058	7.531e-142	463.0	COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,2TU59@28211|Alphaproteobacteria,2JQ52@204441|Rhodospirillales	204441|Rhodospirillales	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
SHD2_k127_4249803_16	1282360.ABAC460_03680	2.63e-124	404.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,2TR2P@28211|Alphaproteobacteria,2KFF0@204458|Caulobacterales	204458|Caulobacterales	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SHD2_k127_4249803_33	1217718.ALOU01000045_gene4105	2.138e-47	181.0	COG0845@1|root,COG0845@2|Bacteria,1R3U4@1224|Proteobacteria,2VNQ2@28216|Betaproteobacteria,1K0P5@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Secretion protein	-	-	-	ko:K01993	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3
SHD2_k127_4249803_27	414684.RC1_2055	1.874e-52	192.0	COG1309@1|root,COG1309@2|Bacteria,1MVQV@1224|Proteobacteria,2TRPA@28211|Alphaproteobacteria,2JTGB@204441|Rhodospirillales	204441|Rhodospirillales	K	Bacterial transcriptional repressor C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_11,TetR_N
SHD2_k127_4249803_43	1123261.AXDW01000005_gene2576	2.517e-31	130.0	2CX65@1|root,32T1A@2|Bacteria,1MZ48@1224|Proteobacteria,1SDHD@1236|Gammaproteobacteria,1X8U6@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_4249803_47	224914.BMEI0037	4.753e-13	72.0	COG0425@1|root,COG0425@2|Bacteria,1QAA1@1224|Proteobacteria,2VAUQ@28211|Alphaproteobacteria,1J3A7@118882|Brucellaceae	28211|Alphaproteobacteria	O	Sulfurtransferase TusA	-	-	-	ko:K04085	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	TusA
SHD2_k127_4249803_8	59538.XP_005978243.1	1.148e-195	627.0	KOG1179@1|root,KOG1179@2759|Eukaryota,38B7F@33154|Opisthokonta,3BA3X@33208|Metazoa,3CRF3@33213|Bilateria,483GM@7711|Chordata,48US4@7742|Vertebrata,3J7A8@40674|Mammalia	33208|Metazoa	I	AMP-binding enzyme	-	-	6.2.1.3	ko:K08746,ko:K08749	ko03320,ko04146,ko04931,map03320,map04146,map04931	-	-	-	ko00000,ko00001,ko01000,ko01004,ko02000	4.C.1.1,4.C.1.1.5	-	-	AMP-binding,AMP-binding_C
SHD2_k127_4249803_37	315730.BcerKBAB4_2754	3.437e-35	141.0	COG1335@1|root,COG1335@2|Bacteria,1UISN@1239|Firmicutes,4ISRH@91061|Bacilli,1ZQ6X@1386|Bacillus	91061|Bacilli	Q	Isochorismatase family	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
SHD2_k127_4249803_40	1287276.X752_11565	1.53e-33	134.0	COG3791@1|root,COG3791@2|Bacteria,1NC41@1224|Proteobacteria,2UGK2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Glutathione-dependent formaldehyde-activating	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_4249803_12	1333998.M2A_1988	4.91e-140	455.0	COG2141@1|root,COG2141@2|Bacteria,1NKS6@1224|Proteobacteria,2TT87@28211|Alphaproteobacteria,4BRU8@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Luciferase-like monooxygenase	-	-	1.14.13.107	ko:K14733	ko00903,map00903	-	R06398,R09385,R09389,R09393	RC01506	ko00000,ko00001,ko01000	-	-	-	Bac_luciferase
SHD2_k127_4249803_17	551789.ATVJ01000001_gene1131	2.273e-120	404.0	COG0154@1|root,COG0154@2|Bacteria,1MW3Z@1224|Proteobacteria,2TS56@28211|Alphaproteobacteria,43X34@69657|Hyphomonadaceae	28211|Alphaproteobacteria	J	COG0154 Asp-tRNAAsn Glu-tRNAGln amidotransferase A subunit and related amidases	-	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
SHD2_k127_4249803_21	247634.GPB2148_1995	7.513e-105	351.0	COG1063@1|root,COG1063@2|Bacteria,1MV9A@1224|Proteobacteria,1RY4R@1236|Gammaproteobacteria,1J7ZG@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Alcohol dehydrogenase GroES-like domain	adh	-	1.1.1.303,1.1.1.4	ko:K00004	ko00650,map00650	-	R02855,R02946,R10504	RC00205,RC00525	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_N_assoc,ADH_zinc_N
SHD2_k127_4249803_48	402881.Plav_1076	6.615e-05	51.0	COG5388@1|root,COG5388@2|Bacteria,1NFX7@1224|Proteobacteria,2UGRY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	PAS_5
SHD2_k127_4249803_13	1429916.X566_12620	1.137e-135	439.0	COG2130@1|root,COG2130@2|Bacteria,1MUC2@1224|Proteobacteria,2TQYM@28211|Alphaproteobacteria,3JRF5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	N-terminal domain of oxidoreductase	-	-	-	ko:K07119	-	-	-	-	ko00000	-	-	-	ADH_N_2,ADH_zinc_N
SHD2_k127_4249803_39	1429916.X566_24385	2.361e-34	135.0	COG2128@1|root,COG2128@2|Bacteria,1QW8V@1224|Proteobacteria,2TWTB@28211|Alphaproteobacteria,3JZDW@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_4249803_23	1317118.ATO8_02955	1.677e-69	242.0	COG0688@1|root,COG0688@2|Bacteria,1MW45@1224|Proteobacteria,2TRMG@28211|Alphaproteobacteria,4KKAF@93682|Roseivivax	28211|Alphaproteobacteria	I	Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer)	psd	-	4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PS_Dcarbxylase
SHD2_k127_4249803_25	1150626.PHAMO_40125	4.644e-59	216.0	COG1183@1|root,COG1183@2|Bacteria,1MWD9@1224|Proteobacteria,2TUF7@28211|Alphaproteobacteria,2JPXY@204441|Rhodospirillales	204441|Rhodospirillales	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pssA	-	2.7.8.8	ko:K17103	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	M00093	R01800	RC00002,RC00017,RC02795	ko00000,ko00001,ko00002,ko01000	-	-	-	CDP-OH_P_tran_2,CDP-OH_P_transf
SHD2_k127_4249803_28	1408418.JNJH01000008_gene2541	7.375e-52	193.0	COG4420@1|root,COG4420@2|Bacteria,1NXP9@1224|Proteobacteria,2USZD@28211|Alphaproteobacteria,2JX33@204441|Rhodospirillales	204441|Rhodospirillales	S	Protein of unknown function (DUF1003)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1003
SHD2_k127_4249803_41	1382303.JPOM01000001_gene2447	7.097e-33	138.0	28HPC@1|root,2Z7XD@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4337)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4337
SHD2_k127_4249803_15	1549858.MC45_08345	5.129e-125	413.0	COG1473@1|root,COG1473@2|Bacteria,1MUIV@1224|Proteobacteria,2TR5B@28211|Alphaproteobacteria,2K0AI@204457|Sphingomonadales	204457|Sphingomonadales	S	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
SHD2_k127_4249803_3	402881.Plav_0755	1.639e-248	775.0	COG0028@1|root,COG0028@2|Bacteria,1MX6Q@1224|Proteobacteria,2TR5N@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EH	Thiamine pyrophosphate-requiring enzymes acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase	-	-	2.2.1.6,4.1.1.7	ko:K01576,ko:K01652	ko00290,ko00627,ko00650,ko00660,ko00770,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00290,map00627,map00650,map00660,map00770,map01100,map01110,map01120,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R01764,R02672,R03050,R04672,R04673,R08648	RC00027,RC00106,RC00595,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
SHD2_k127_4249803_34	1068980.ARVW01000001_gene2401	8.493e-46	169.0	COG0789@1|root,COG0789@2|Bacteria,2IQ8P@201174|Actinobacteria,4E5MN@85010|Pseudonocardiales	201174|Actinobacteria	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17
SHD2_k127_4249803_22	994479.GL877884_gene7592	1.023e-80	277.0	COG2267@1|root,COG2267@2|Bacteria,2I2QH@201174|Actinobacteria,4E313@85010|Pseudonocardiales	201174|Actinobacteria	I	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
SHD2_k127_4249803_38	1463926.JOCA01000007_gene4183	1.305e-34	138.0	2E49F@1|root,32Z57@2|Bacteria,2IKMB@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF4180)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4180
SHD2_k127_4249803_30	670307.HYPDE_36683	5.641e-49	177.0	COG0640@1|root,COG0640@2|Bacteria,1RH5P@1224|Proteobacteria,2U960@28211|Alphaproteobacteria,3N8NC@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Bacterial regulatory protein, arsR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
SHD2_k127_4249803_29	1210884.HG799471_gene14625	4.342e-51	188.0	COG3832@1|root,COG3832@2|Bacteria,2J16I@203682|Planctomycetes	203682|Planctomycetes	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
SHD2_k127_4249803_26	1329516.JPST01000061_gene1752	9.484e-58	206.0	COG3832@1|root,COG3832@2|Bacteria,1V5ZQ@1239|Firmicutes,4HGZ1@91061|Bacilli,27DAZ@186824|Thermoactinomycetaceae	91061|Bacilli	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
SHD2_k127_4249803_0	450851.PHZ_c1832	1.363e-316	977.0	COG2072@1|root,COG2072@2|Bacteria,1MUQH@1224|Proteobacteria,2TRG4@28211|Alphaproteobacteria,2KGKD@204458|Caulobacterales	204458|Caulobacterales	C	Flavin-binding monooxygenase-like	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_3
SHD2_k127_4249803_42	1297865.APJD01000020_gene186	1.227e-32	132.0	COG1017@1|root,COG1017@2|Bacteria,1REV4@1224|Proteobacteria,2U757@28211|Alphaproteobacteria,3JZ5V@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	nitric oxide dioxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_4249803_32	596154.Alide2_0255	4.758e-48	177.0	COG3832@1|root,COG3832@2|Bacteria,1REB4@1224|Proteobacteria,2WG2H@28216|Betaproteobacteria,4AJUC@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM Activator of Hsp90 ATPase	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
SHD2_k127_4249803_44	509190.Cseg_1213	3.082e-30	121.0	COG1773@1|root,COG1773@2|Bacteria,1PEC2@1224|Proteobacteria,2UG6D@28211|Alphaproteobacteria,2KJ9T@204458|Caulobacterales	204458|Caulobacterales	C	Rubredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Rubredoxin
SHD2_k127_4249803_24	509190.Cseg_1215	1.051e-61	219.0	COG1309@1|root,COG1309@2|Bacteria,1RIH0@1224|Proteobacteria,2UAQ0@28211|Alphaproteobacteria,2KIUU@204458|Caulobacterales	204458|Caulobacterales	K	BetI-type transcriptional repressor, C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_6,TetR_N
SHD2_k127_4249803_4	366602.Caul_3446	8.093e-221	691.0	COG2124@1|root,COG2124@2|Bacteria,1MV8Q@1224|Proteobacteria,2TU15@28211|Alphaproteobacteria,2KFJ6@204458|Caulobacterales	204458|Caulobacterales	C	cytochrome P450	-	-	-	-	-	-	-	-	-	-	-	-	p450
SHD2_k127_4249803_5	1304878.AUGD01000024_gene4027	8.078e-210	663.0	COG0076@1|root,COG0076@2|Bacteria,1MWUX@1224|Proteobacteria,2TTUK@28211|Alphaproteobacteria,3JV5F@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Pyridoxal-dependent decarboxylase conserved domain	MA20_08345	-	4.1.1.105,4.1.1.28	ko:K01593	ko00350,ko00360,ko00380,ko00901,ko00950,ko00965,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00350,map00360,map00380,map00901,map00950,map00965,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00037,M00042	R00685,R00699,R00736,R02080,R02701,R04909	RC00299	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyridoxal_deC
SHD2_k127_4249803_10	443598.AUFA01000010_gene323	4.045e-150	486.0	COG0189@1|root,COG0189@2|Bacteria,1NNP5@1224|Proteobacteria,2TSU2@28211|Alphaproteobacteria,3JR2E@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	HJ	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_4249803_19	113395.AXAI01000011_gene6519	9.018e-117	395.0	COG0520@1|root,COG0520@2|Bacteria,1QEVJ@1224|Proteobacteria,2TX67@28211|Alphaproteobacteria,3JTSQ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_4249803_9	1247963.JPHU01000002_gene2430	1.962e-167	534.0	COG1680@1|root,COG1680@2|Bacteria,1MXHB@1224|Proteobacteria,2U4GK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	COG1680 Beta-lactamase class C and other penicillin binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
SHD2_k127_4249803_18	504472.Slin_0149	4.838e-117	389.0	COG0665@1|root,COG0665@2|Bacteria,4NKQK@976|Bacteroidetes,47Q2W@768503|Cytophagia	976|Bacteroidetes	E	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
SHD2_k127_4249803_6	402881.Plav_2705	1.384e-198	629.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2TRYI@28211|Alphaproteobacteria,1JNNJ@119043|Rhodobiaceae	28211|Alphaproteobacteria	C	FAD linked oxidases, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD-oxidase_C,FAD_binding_4
SHD2_k127_4249803_2	1280944.HY17_07235	5.558e-277	860.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TR2W@28211|Alphaproteobacteria,43X1D@69657|Hyphomonadaceae	28211|Alphaproteobacteria	IQ	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
SHD2_k127_4249803_45	1123269.NX02_04765	2.257e-21	104.0	COG0664@1|root,COG0664@2|Bacteria,1MXID@1224|Proteobacteria,2TT42@28211|Alphaproteobacteria,2K3CE@204457|Sphingomonadales	204457|Sphingomonadales	K	COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
SHD2_k127_4249803_31	1123267.JONN01000001_gene1239	6.794e-49	188.0	2C1YS@1|root,2ZD2Y@2|Bacteria	2|Bacteria	S	Protease prsW family	-	-	-	-	-	-	-	-	-	-	-	-	PrsW-protease
SHD2_k127_4249803_1	1123267.JONN01000001_gene1238	9.042e-315	992.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,MRJP
SHD2_k127_4374087_22	1245469.S58_14570	3.137e-85	283.0	COG0662@1|root,COG0662@2|Bacteria,1RJ7D@1224|Proteobacteria,2UAG4@28211|Alphaproteobacteria,3K36C@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
SHD2_k127_4374087_53	1089552.KI911559_gene1979	4.903e-10	67.0	COG5388@1|root,COG5388@2|Bacteria,1N8ZE@1224|Proteobacteria,2UMI1@28211|Alphaproteobacteria,2JUHQ@204441|Rhodospirillales	204441|Rhodospirillales	T	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	PAS_5
SHD2_k127_4374087_38	1545915.JROG01000008_gene3377	5.329e-41	154.0	COG1393@1|root,COG1393@2|Bacteria,1MZ4Z@1224|Proteobacteria,2U70U@28211|Alphaproteobacteria,2K413@204457|Sphingomonadales	204457|Sphingomonadales	P	arsenate reductase	-	-	1.20.4.1	ko:K00537	-	-	-	-	ko00000,ko01000	-	-	-	ArsC
SHD2_k127_4374087_26	1157640.AQWO01000004_gene4935	6.395e-67	239.0	COG0412@1|root,COG0412@2|Bacteria,2H3SA@201174|Actinobacteria	201174|Actinobacteria	Q	Dienelactone hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_4374087_23	450851.PHZ_c1140	9.827e-78	266.0	COG0824@1|root,COG0824@2|Bacteria,1R6A6@1224|Proteobacteria,2TU6J@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Thioesterase	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_4374087_41	876269.ARWA01000001_gene58	2.666e-35	154.0	COG0790@1|root,COG0790@2|Bacteria,1MWPA@1224|Proteobacteria,2TR2B@28211|Alphaproteobacteria,3NB1V@45404|Beijerinckiaceae	28211|Alphaproteobacteria	L	Sel1-like repeats.	-	-	-	ko:K07126,ko:K13582	ko04112,map04112	-	-	-	ko00000,ko00001	-	-	-	PG_binding_1,Sel1
SHD2_k127_4374087_16	463191.SSEG_10582	3.966e-102	344.0	COG1680@1|root,COG1680@2|Bacteria,2GJJB@201174|Actinobacteria	201174|Actinobacteria	V	COG1680 Beta-lactamase class C and other penicillin binding proteins	lipP	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
SHD2_k127_4374087_18	1382303.JPOM01000001_gene2284	2.29e-97	325.0	COG0672@1|root,COG0672@2|Bacteria,1MXHM@1224|Proteobacteria,2U17C@28211|Alphaproteobacteria,2KFCB@204458|Caulobacterales	204458|Caulobacterales	P	Iron permease FTR1 family	-	-	-	ko:K07243	-	-	-	-	ko00000,ko02000	2.A.108.1,2.A.108.2	-	-	Cytochrome_CBB3,FTR1
SHD2_k127_4374087_46	1382303.JPOM01000001_gene2283	5.189e-26	112.0	COG4633@1|root,COG4633@2|Bacteria,1N6VB@1224|Proteobacteria,2UFK9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Cupredoxin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1
SHD2_k127_4374087_10	1205753.A989_15617	1.36e-151	499.0	COG1215@1|root,COG1215@2|Bacteria,1MX08@1224|Proteobacteria,1SU7S@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Glycosyl transferase family group 2	-	-	-	ko:K20327	ko02024,map02024	-	-	-	ko00000,ko00001,ko01003	-	GT2	-	Glyco_tranf_2_3,Glyco_trans_2_3,T2SSE_N
SHD2_k127_4374087_48	316058.RPB_4107	1.173e-23	113.0	2BCV0@1|root,326FP@2|Bacteria,1MYXP@1224|Proteobacteria,2U5PU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	ko:K20326	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Phenol_MetA_deg
SHD2_k127_4374087_15	1282876.BAOK01000001_gene1683	2.561e-110	364.0	COG4221@1|root,COG4221@2|Bacteria,1MVYG@1224|Proteobacteria,2TSTP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
SHD2_k127_4374087_12	402881.Plav_2713	2.122e-137	445.0	2EXDM@1|root,33QQ7@2|Bacteria,1NTQ6@1224|Proteobacteria,2UQVJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_4374087_40	1282876.BAOK01000001_gene1681	6.172e-38	152.0	COG1309@1|root,COG1309@2|Bacteria,1NJZH@1224|Proteobacteria,2URBM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
SHD2_k127_4374087_47	1397666.RS24_01600	1.953e-24	111.0	COG0457@1|root,COG0457@2|Bacteria,1N6TJ@1224|Proteobacteria,2UG5W@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2,TPR_8
SHD2_k127_4374087_1	1123072.AUDH01000002_gene2554	2.494e-239	768.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TQMW@28211|Alphaproteobacteria,2JQY7@204441|Rhodospirillales	204441|Rhodospirillales	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
SHD2_k127_4374087_14	1220535.IMCC14465_16790	2.08e-115	376.0	COG0235@1|root,COG0235@2|Bacteria,1MWP9@1224|Proteobacteria,2TRMV@28211|Alphaproteobacteria,4BS5M@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	G	Class II Aldolase and Adducin N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Aldolase_II
SHD2_k127_4374087_7	1149133.ppKF707_1178	2.877e-195	621.0	COG0554@1|root,COG0554@2|Bacteria,1MUP7@1224|Proteobacteria,1RMAF@1236|Gammaproteobacteria,1YDPI@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	F	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK	GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
SHD2_k127_4374087_54	414684.RC1_2184	0.0002382	50.0	COG5388@1|root,COG5388@2|Bacteria,1NFX7@1224|Proteobacteria,2UGRY@28211|Alphaproteobacteria,2JU1H@204441|Rhodospirillales	204441|Rhodospirillales	S	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	PAS_5
SHD2_k127_4374087_32	570967.JMLV01000002_gene1587	1.824e-55	208.0	COG5330@1|root,COG5330@2|Bacteria,1R3VY@1224|Proteobacteria,2TUQ8@28211|Alphaproteobacteria,2JPXM@204441|Rhodospirillales	204441|Rhodospirillales	S	Uncharacterised protein conserved in bacteria (DUF2336)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2336
SHD2_k127_4374087_8	1353531.AZNX01000002_gene4955	8.243e-163	517.0	COG2896@1|root,COG2896@2|Bacteria,1MW3W@1224|Proteobacteria,2TQQP@28211|Alphaproteobacteria,4B7SU@82115|Rhizobiaceae	28211|Alphaproteobacteria	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Mob_synth_C,Radical_SAM
SHD2_k127_4374087_19	1123072.AUDH01000004_gene532	6.163e-93	311.0	COG0061@1|root,COG0061@2|Bacteria,1MUBC@1224|Proteobacteria,2TSKN@28211|Alphaproteobacteria,2JPIS@204441|Rhodospirillales	204441|Rhodospirillales	H	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
SHD2_k127_4374087_24	1333998.M2A_2504	6.633e-70	245.0	COG0494@1|root,COG0494@2|Bacteria,1NTFG@1224|Proteobacteria,2U0I4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Hydrolase	MA20_35615	-	-	-	-	-	-	-	-	-	-	-	NUDIX
SHD2_k127_4374087_25	1307759.JOMJ01000003_gene2210	6.931e-69	248.0	COG0477@1|root,COG0477@2|Bacteria,1QTUM@1224|Proteobacteria,42M2U@68525|delta/epsilon subdivisions	1224|Proteobacteria	EGP	Major Facilitator	ycaD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K08219	-	-	-	-	ko00000,ko02000	2.A.1.26	-	-	MFS_1,Sugar_tr
SHD2_k127_4374087_34	1449049.JONW01000001_gene3445	1.023e-51	198.0	COG0741@1|root,COG0741@2|Bacteria,1MUMA@1224|Proteobacteria,2TSA5@28211|Alphaproteobacteria,2KFYM@204458|Caulobacterales	204458|Caulobacterales	M	Lytic transglycosylase	-	-	-	-	-	-	-	-	-	-	-	-	SLT
SHD2_k127_4374087_39	1279038.KB907337_gene580	3.682e-40	153.0	COG0537@1|root,COG0537@2|Bacteria,1MZVD@1224|Proteobacteria,2UC00@28211|Alphaproteobacteria,2JTBW@204441|Rhodospirillales	204441|Rhodospirillales	FG	COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases	-	-	-	-	-	-	-	-	-	-	-	-	HIT
SHD2_k127_4374087_27	1128421.JAGA01000001_gene2163	9.973e-67	242.0	COG0665@1|root,COG0665@2|Bacteria,2NP0X@2323|unclassified Bacteria	2|Bacteria	E	FAD dependent oxidoreductase	thiO	-	1.4.3.19,1.4.5.1	ko:K00285,ko:K03153	ko00360,ko00730,ko01100,map00360,map00730,map01100	-	R01374,R07463,R09493	RC00006,RC00025,RC01788	ko00000,ko00001,ko01000	-	-	-	DAO
SHD2_k127_4374087_52	675813.VIB_001131	8.32e-13	76.0	COG0558@1|root,COG0558@2|Bacteria,1RD5Y@1224|Proteobacteria,1RZ4Q@1236|Gammaproteobacteria,1Y2BY@135623|Vibrionales	135623|Vibrionales	I	CDP-alcohol phosphatidyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	CDP-OH_P_transf
SHD2_k127_4374087_29	1198114.AciX9_3304	3.406e-63	222.0	COG0225@1|root,COG0225@2|Bacteria,3Y4DM@57723|Acidobacteria,2JJ10@204432|Acidobacteriia	204432|Acidobacteriia	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	-	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
SHD2_k127_4374087_2	518766.Rmar_2546	7.897e-230	725.0	COG0405@1|root,COG0405@2|Bacteria,4NF2H@976|Bacteroidetes,1FJ35@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	E	Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
SHD2_k127_4374087_28	1089552.KI911559_gene2538	4.451e-66	239.0	COG3336@1|root,COG3336@2|Bacteria,1RAW2@1224|Proteobacteria,2U8R3@28211|Alphaproteobacteria,2JWKU@204441|Rhodospirillales	204441|Rhodospirillales	S	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG)	-	-	-	ko:K02351	-	-	-	-	ko00000	-	-	-	Caa3_CtaG
SHD2_k127_4374087_33	1417296.U879_04310	1.415e-53	196.0	COG1999@1|root,COG1999@2|Bacteria,1RKIP@1224|Proteobacteria,2UEBK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	SCO1/SenC	-	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	SCO1-SenC
SHD2_k127_4374087_4	1282876.BAOK01000001_gene2165	8.595e-210	660.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2TR8H@28211|Alphaproteobacteria,4BPKF@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	lpd	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
SHD2_k127_4374087_45	1161401.ASJA01000005_gene2504	5.978e-28	126.0	COG1566@1|root,COG1566@2|Bacteria,1R50C@1224|Proteobacteria,2TUCN@28211|Alphaproteobacteria,440SZ@69657|Hyphomonadaceae	28211|Alphaproteobacteria	V	Protein of unknown function (DUF3667)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3667
SHD2_k127_4374087_11	266834.SMc01032	7.826e-143	466.0	COG0508@1|root,COG0508@2|Bacteria,1MUGY@1224|Proteobacteria,2TRXM@28211|Alphaproteobacteria,4B79R@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	pdhC	-	1.2.4.1,2.3.1.12	ko:K00162,ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R02569,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02857,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
SHD2_k127_4374087_36	1283300.ATXB01000001_gene426	8.154e-47	172.0	COG3791@1|root,COG3791@2|Bacteria,1RHWZ@1224|Proteobacteria,1S4HQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Glutathione-dependent formaldehyde-activating	-	-	-	-	-	-	-	-	-	-	-	-	GFA
SHD2_k127_4374087_6	391937.NA2_13335	2.11e-196	621.0	COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,2TRMR@28211|Alphaproteobacteria,43IG5@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	pdhB	-	1.2.4.1	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_lipoyl,Transket_pyr,Transketolase_C
SHD2_k127_4374087_9	1040989.AWZU01000003_gene6839	3.274e-155	496.0	COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,2TRSS@28211|Alphaproteobacteria,3JS9V@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	pdhA	-	1.2.4.1	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
SHD2_k127_4374087_51	1123355.JHYO01000007_gene434	2.225e-13	74.0	COG2919@1|root,COG2919@2|Bacteria,1N8WI@1224|Proteobacteria,2UGEU@28211|Alphaproteobacteria,36YZ1@31993|Methylocystaceae	28211|Alphaproteobacteria	D	Septum formation initiator	MA20_41765	-	-	-	-	-	-	-	-	-	-	-	DivIC
SHD2_k127_4374087_3	991905.SL003B_2232	4.584e-213	668.0	COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,2TR04@28211|Alphaproteobacteria,4BPPV@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
SHD2_k127_4374087_44	666685.R2APBS1_1151	6.149e-30	124.0	COG3788@1|root,COG3788@2|Bacteria,1NBHH@1224|Proteobacteria,1SBVZ@1236|Gammaproteobacteria,1X80C@135614|Xanthomonadales	135614|Xanthomonadales	S	MAPEG family	-	-	-	-	-	-	-	-	-	-	-	-	MAPEG
SHD2_k127_4374087_13	648757.Rvan_0360	1.007e-121	396.0	COG2877@1|root,COG2877@2|Bacteria,1MV91@1224|Proteobacteria,2TRJX@28211|Alphaproteobacteria,3N7VD@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	3-deoxy-D-manno-octulosonic acid 8-phosphate synthase	kdsA	-	2.5.1.55	ko:K01627	ko00540,ko01100,map00540,map01100	M00063	R03254	RC00435	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	DAHP_synth_1
SHD2_k127_4374087_35	1168059.KB899087_gene2857	2.256e-47	177.0	COG1596@1|root,COG1596@2|Bacteria,1MXYS@1224|Proteobacteria,2U93S@28211|Alphaproteobacteria,3F1QG@335928|Xanthobacteraceae	28211|Alphaproteobacteria	M	Polysaccharide biosynthesis/export protein	-	-	-	ko:K01991	ko02026,map02026	-	-	-	ko00000,ko00001,ko02000	1.B.18	-	-	Poly_export,SLBB
SHD2_k127_4374087_17	395964.KE386496_gene385	7.935e-99	344.0	COG2124@1|root,COG2124@2|Bacteria,1MV75@1224|Proteobacteria,2TSV7@28211|Alphaproteobacteria,3NC5P@45404|Beijerinckiaceae	28211|Alphaproteobacteria	C	Cytochrome P450	-	-	-	-	-	-	-	-	-	-	-	-	p450
SHD2_k127_4374087_50	215803.DB30_4830	1.971e-19	93.0	COG3860@1|root,COG3860@2|Bacteria,1NB8Z@1224|Proteobacteria,43BAC@68525|delta/epsilon subdivisions,2X6PI@28221|Deltaproteobacteria,2Z3C3@29|Myxococcales	28221|Deltaproteobacteria	S	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_4374087_0	1123229.AUBC01000006_gene1048	3.531e-267	831.0	COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,2TS4Y@28211|Alphaproteobacteria,3JTRN@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
SHD2_k127_4374087_49	1510531.JQJJ01000011_gene2661	1.633e-21	98.0	COG1314@1|root,COG1314@2|Bacteria,1N8MF@1224|Proteobacteria,2UCIP@28211|Alphaproteobacteria,3JYS8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	U	Preprotein translocase SecG subunit	secG	-	-	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecG
SHD2_k127_4374087_42	394221.Mmar10_1406	8.771e-35	146.0	COG2199@1|root,COG3706@2|Bacteria,1NCGI@1224|Proteobacteria,2TXU2@28211|Alphaproteobacteria,43Z9U@69657|Hyphomonadaceae	28211|Alphaproteobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_4374087_21	1122929.KB908233_gene3752	2.006e-86	293.0	COG0149@1|root,COG0149@2|Bacteria,1MWK5@1224|Proteobacteria,2TS6I@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
SHD2_k127_4374087_20	883078.HMPREF9695_01995	7.861e-89	317.0	COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,2TRYU@28211|Alphaproteobacteria,3JQRF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Peptidylprolyl isomerase	ppiD	-	5.2.1.8	ko:K01802,ko:K03770	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase_2,SurA_N_3
SHD2_k127_4374087_5	1121033.AUCF01000004_gene5045	3.723e-203	644.0	COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,2TRWB@28211|Alphaproteobacteria,2JQBT@204441|Rhodospirillales	204441|Rhodospirillales	E	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
SHD2_k127_4374087_31	1121033.AUCF01000006_gene4367	1.31e-57	219.0	COG2861@1|root,COG2861@2|Bacteria,1N3JP@1224|Proteobacteria,2TUFD@28211|Alphaproteobacteria,2JRXP@204441|Rhodospirillales	204441|Rhodospirillales	S	protein conserved in bacteria	-	-	-	ko:K09798	-	-	-	-	ko00000	-	-	-	Polysacc_deac_2
SHD2_k127_4374087_37	402881.Plav_0446	1.711e-45	166.0	2B9KW@1|root,322Z5@2|Bacteria,1RJJB@1224|Proteobacteria,2UAVD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_4374087_30	450851.PHZ_c1002	2.109e-60	215.0	COG1546@1|root,COG1546@2|Bacteria,1RHXH@1224|Proteobacteria,2UACN@28211|Alphaproteobacteria,2KISA@204458|Caulobacterales	204458|Caulobacterales	S	Competence-damaged protein	-	-	-	-	-	-	-	-	-	-	-	-	CinA
SHD2_k127_4398134_12	1005048.CFU_1434	1.668e-83	288.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2VJTV@28216|Betaproteobacteria,47284@75682|Oxalobacteraceae	28216|Betaproteobacteria	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
SHD2_k127_4398134_5	448385.sce1969	6.214e-142	457.0	COG0667@1|root,COG0667@2|Bacteria,1MV2Y@1224|Proteobacteria,42MVI@68525|delta/epsilon subdivisions,2WXF1@28221|Deltaproteobacteria,2YU87@29|Myxococcales	28221|Deltaproteobacteria	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
SHD2_k127_4398134_24	633149.Bresu_1720	2.574e-07	57.0	COG3496@1|root,COG3496@2|Bacteria,1RC56@1224|Proteobacteria,2TUX0@28211|Alphaproteobacteria,2KGJK@204458|Caulobacterales	204458|Caulobacterales	S	Protein of unknown function (DUF1365)	-	-	-	ko:K09701	-	-	-	-	ko00000	-	-	-	DUF1365
SHD2_k127_4398134_4	1282876.BAOK01000001_gene2576	4.179e-148	477.0	COG1960@1|root,COG1960@2|Bacteria,1MW0F@1224|Proteobacteria,2TR9I@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	acyl-CoA dehydrogenase	MA20_40060	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
SHD2_k127_4398134_16	1114964.L485_16975	2.131e-49	189.0	COG1960@1|root,COG1960@2|Bacteria,1NQAE@1224|Proteobacteria,2U0TJ@28211|Alphaproteobacteria,2K1RF@204457|Sphingomonadales	204457|Sphingomonadales	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1
SHD2_k127_4398134_1	450851.PHZ_c3245	2.615e-206	646.0	COG0183@1|root,COG0183@2|Bacteria,1MUZV@1224|Proteobacteria,2TRHF@28211|Alphaproteobacteria,2KH0C@204458|Caulobacterales	204458|Caulobacterales	I	acetyl-coa acetyltransferase	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	-
SHD2_k127_4398134_17	1038860.AXAP01000014_gene991	6.229e-48	175.0	COG1545@1|root,COG1545@2|Bacteria,1RB09@1224|Proteobacteria,2U5BV@28211|Alphaproteobacteria,3JY0M@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	DUF35 OB-fold domain, acyl-CoA-associated	MA20_35595	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
SHD2_k127_4398134_19	1157490.EL26_13680	1.011e-44	168.0	2DMXW@1|root,32UAS@2|Bacteria,1V8D1@1239|Firmicutes,4HIRE@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_4398134_20	717785.HYPMC_3272	1.006e-43	167.0	COG2135@1|root,COG2135@2|Bacteria,1NXVH@1224|Proteobacteria,2UT6M@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Belongs to the SOS response-associated peptidase family	-	-	-	-	-	-	-	-	-	-	-	-	SRAP
SHD2_k127_4398134_14	709797.CSIRO_4112	1.814e-53	196.0	COG0500@1|root,COG0500@2|Bacteria,1NM6Y@1224|Proteobacteria,2UR09@28211|Alphaproteobacteria,3K31N@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Nodulation protein S (NodS)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
SHD2_k127_4398134_10	172088.AUGA01000058_gene6201	6.505e-98	327.0	COG1028@1|root,COG1028@2|Bacteria,1MU3W@1224|Proteobacteria,2TT5X@28211|Alphaproteobacteria,3JU5R@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IQ	KR domain	MA20_31015	-	1.1.1.304,1.1.1.76	ko:K18009	ko00650,map00650	-	R03707,R09078,R10505	RC00205,RC00525	ko00000,ko00001,ko01000	-	-	-	adh_short_C2
SHD2_k127_4398134_2	1205680.CAKO01000002_gene2515	1.082e-195	624.0	COG0488@1|root,COG0488@2|Bacteria,1MX6Y@1224|Proteobacteria,2U10A@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
SHD2_k127_4398134_9	1429916.X566_07680	2.774e-99	329.0	COG0346@1|root,COG0346@2|Bacteria,1MXZY@1224|Proteobacteria,2U2AQ@28211|Alphaproteobacteria,3JWWA@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
SHD2_k127_4398134_11	478741.JAFS01000001_gene1399	3.206e-88	301.0	2C1VH@1|root,2Z7Z3@2|Bacteria,46YUE@74201|Verrucomicrobia,37FW5@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	S	3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) hydroxylase	-	-	-	-	-	-	-	-	-	-	-	-	Kdo_hydroxy
SHD2_k127_4398134_15	1128421.JAGA01000002_gene1741	4.015e-52	195.0	COG1752@1|root,COG1752@2|Bacteria	2|Bacteria	M	Esterase of the alpha-beta hydrolase superfamily	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
SHD2_k127_4398134_8	1121033.AUCF01000010_gene4453	8.357e-102	344.0	COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,2TSGS@28211|Alphaproteobacteria,2JQEM@204441|Rhodospirillales	204441|Rhodospirillales	Q	Permease MlaE	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE,STAS_2
SHD2_k127_4398134_7	1282876.BAOK01000001_gene1472	1.095e-104	347.0	COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,2TR2I@28211|Alphaproteobacteria,4BQAM@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	Q	ATPases associated with a variety of cellular activities	yrbF	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
SHD2_k127_4398134_18	1380394.JADL01000001_gene2823	1.271e-45	176.0	COG1463@1|root,COG1463@2|Bacteria,1MU4B@1224|Proteobacteria,2U1JN@28211|Alphaproteobacteria,2JS8K@204441|Rhodospirillales	204441|Rhodospirillales	Q	MlaD protein	-	-	-	ko:K02067,ko:K06192	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
SHD2_k127_4398134_21	414684.RC1_1440	2.17e-30	129.0	COG3218@1|root,COG3218@2|Bacteria,1RI22@1224|Proteobacteria,2UB1D@28211|Alphaproteobacteria,2JT67@204441|Rhodospirillales	204441|Rhodospirillales	S	ABC-type transport auxiliary lipoprotein component	-	-	-	ko:K18480	-	M00669	-	-	ko00000,ko00002,ko02000	3.A.1.27.1	-	-	ABC_trans_aux
SHD2_k127_4398134_6	391600.ABRU01000031_gene2943	9.166e-122	402.0	COG0121@1|root,COG0671@1|root,COG0121@2|Bacteria,COG0671@2|Bacteria,1Q80V@1224|Proteobacteria,2U155@28211|Alphaproteobacteria,2KFYD@204458|Caulobacterales	204458|Caulobacterales	I	Phosphoinositide phospholipase C, Ca2+-dependent	-	-	-	-	-	-	-	-	-	-	-	-	PAP2,PI-PLC-C1
SHD2_k127_4398134_22	1123229.AUBC01000004_gene3141	8.766e-17	85.0	2EHCE@1|root,33B49@2|Bacteria,1RHFN@1224|Proteobacteria,2UD1E@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_4398134_0	1211115.ALIQ01000234_gene4132	4.53e-254	796.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2TR3X@28211|Alphaproteobacteria,3NABZ@45404|Beijerinckiaceae	28211|Alphaproteobacteria	S	ABC transporter C-terminal domain	uup	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0009314,GO:0009628,GO:0010528,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0031323,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0060255,GO:0065007,GO:0070894,GO:0071944,GO:0080090,GO:0097159,GO:1901363	-	ko:K15738	-	-	-	-	ko00000,ko02000	3.A.1.120.6	-	-	ABC_tran,ABC_tran_CTD
SHD2_k127_4398134_13	1230476.C207_01476	3.377e-55	205.0	COG2207@1|root,COG2207@2|Bacteria,1R4HX@1224|Proteobacteria,2U6XY@28211|Alphaproteobacteria,3JV2I@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding_2,HTH_18
SHD2_k127_4398134_3	1244869.H261_16867	2.546e-155	504.0	COG0582@1|root,COG0582@2|Bacteria,1MU23@1224|Proteobacteria,2TS2G@28211|Alphaproteobacteria,2JQ5C@204441|Rhodospirillales	204441|Rhodospirillales	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Arm-DNA-bind_3,Phage_integrase
SHD2_k127_4583343_18	247634.GPB2148_3541	1.062e-21	106.0	COG1629@1|root,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,1SJX0@1236|Gammaproteobacteria,1J8GZ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	COG1629 Outer membrane receptor proteins, mostly Fe transport	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
SHD2_k127_4583343_12	1382303.JPOM01000001_gene36	2.726e-75	261.0	COG1028@1|root,COG1028@2|Bacteria,1MUFX@1224|Proteobacteria,2TRWN@28211|Alphaproteobacteria,2KG46@204458|Caulobacterales	204458|Caulobacterales	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
SHD2_k127_4583343_8	1382303.JPOM01000001_gene35	4.608e-108	361.0	COG1028@1|root,COG1028@2|Bacteria,1RKSE@1224|Proteobacteria,2UBGG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
SHD2_k127_4583343_5	1382303.JPOM01000001_gene33	4.741e-156	497.0	COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,2TRSS@28211|Alphaproteobacteria,2KEZE@204458|Caulobacterales	28211|Alphaproteobacteria	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	acoA	-	1.2.4.1,1.2.4.4	ko:K00161,ko:K00166,ko:K21416	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,OxoDH_E1alpha_N
SHD2_k127_4583343_4	1382303.JPOM01000001_gene32	3.549e-163	522.0	COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,2TRFK@28211|Alphaproteobacteria,2KIC9@204458|Caulobacterales	204458|Caulobacterales	C	Transketolase, pyrimidine binding domain	-	-	-	ko:K21417	-	-	-	-	ko00000,ko01000	-	-	-	Transket_pyr,Transketolase_C
SHD2_k127_4583343_7	748247.AZKH_2265	4.335e-115	383.0	COG4638@1|root,COG4638@2|Bacteria,1MWXW@1224|Proteobacteria,2VS7J@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Ring hydroxylating alpha subunit (catalytic domain)	-	-	1.14.13.239,1.14.15.7	ko:K00499,ko:K22443	ko00260,map00260	-	R07409	RC00087	ko00000,ko00001,ko01000	-	-	-	Rieske,Ring_hydroxyl_A
SHD2_k127_4583343_13	748247.AZKH_2297	8.12e-68	238.0	COG0346@1|root,COG0346@2|Bacteria,1MWHG@1224|Proteobacteria,2VJM7@28216|Betaproteobacteria	28216|Betaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase_4
SHD2_k127_4583343_11	158500.BV97_04273	8.656e-81	287.0	COG1028@1|root,COG1028@2|Bacteria,1MUPX@1224|Proteobacteria,2TT6C@28211|Alphaproteobacteria	28211|Alphaproteobacteria	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
SHD2_k127_4583343_3	1382303.JPOM01000001_gene31	1.753e-166	528.0	COG2130@1|root,COG2130@2|Bacteria,1MUC2@1224|Proteobacteria,2TQYM@28211|Alphaproteobacteria,2KGBE@204458|Caulobacterales	204458|Caulobacterales	S	N-terminal domain of oxidoreductase	-	-	-	ko:K07119	-	-	-	-	ko00000	-	-	-	ADH_N_2,ADH_zinc_N
SHD2_k127_4583343_9	1331060.RLDS_04875	1.504e-104	346.0	COG3828@1|root,COG3828@2|Bacteria,1RHWH@1224|Proteobacteria,2UBAF@28211|Alphaproteobacteria,2K2JF@204457|Sphingomonadales	204457|Sphingomonadales	S	Trehalose utilisation	-	-	-	-	-	-	-	-	-	-	-	-	ThuA
SHD2_k127_4583343_10	1122970.AUHC01000011_gene2681	1.011e-96	325.0	COG0702@1|root,COG0702@2|Bacteria,1N65H@1224|Proteobacteria,2UEV9@28211|Alphaproteobacteria,2K8AP@204457|Sphingomonadales	204457|Sphingomonadales	GM	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	NmrA
SHD2_k127_4583343_0	1040989.AWZU01000012_gene1306	1.086e-245	768.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TR2W@28211|Alphaproteobacteria,3JS0G@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	MA20_16355	-	6.2.1.3	ko:K00666,ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
SHD2_k127_4583343_16	1382303.JPOM01000001_gene25	6.211e-39	150.0	COG1545@1|root,COG1545@2|Bacteria,1N9MM@1224|Proteobacteria	1224|Proteobacteria	S	DUF35 OB-fold domain, acyl-CoA-associated	-	-	-	ko:K07549	ko00623,ko01100,ko01120,ko01220,map00623,map01100,map01120,map01220	M00418	R05587	RC00004,RC01428,RC02904	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF35_N,OB_aCoA_assoc
SHD2_k127_4583343_2	1382303.JPOM01000001_gene24	2.433e-209	654.0	COG0183@1|root,COG0183@2|Bacteria,1R5AW@1224|Proteobacteria,2U1UK@28211|Alphaproteobacteria,2KJTP@204458|Caulobacterales	204458|Caulobacterales	I	acetyl-coa acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_4583343_1	1382303.JPOM01000001_gene23	3.623e-213	670.0	COG4638@1|root,COG4638@2|Bacteria,1MWXW@1224|Proteobacteria,2TSJ5@28211|Alphaproteobacteria,2KFDB@204458|Caulobacterales	204458|Caulobacterales	P	Ring hydroxylating alpha subunit (catalytic domain)	-	-	-	-	-	-	-	-	-	-	-	-	Rieske,Ring_hydroxyl_A
SHD2_k127_4583343_6	748247.AZKH_2296	3.288e-122	396.0	COG1028@1|root,COG1028@2|Bacteria,1MXNY@1224|Proteobacteria,2VN50@28216|Betaproteobacteria	28216|Betaproteobacteria	IQ	Short-chain dehydrogenase reductase (SDR)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
SHD2_k127_4583343_15	1123400.KB904760_gene2125	2.923e-39	153.0	2DRRT@1|root,32URI@2|Bacteria,1N4F0@1224|Proteobacteria,1T69J@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_4583343_14	1122604.JONR01000006_gene2734	4.275e-65	235.0	COG1396@1|root,COG1396@2|Bacteria,1MWUC@1224|Proteobacteria,1S1BS@1236|Gammaproteobacteria,1X5KY@135614|Xanthomonadales	135614|Xanthomonadales	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_31
SHD2_k127_4602745_136	420324.KI911943_gene5252	1.083e-33	134.0	COG3316@1|root,COG3316@2|Bacteria,1P9SM@1224|Proteobacteria,2TV17@28211|Alphaproteobacteria,1JY3D@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	DDE domain	-	-	-	ko:K07498	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS240
SHD2_k127_4602745_135	1121123.AUAO01000001_gene784	1.428e-34	136.0	COG3316@1|root,COG3316@2|Bacteria,1P9SM@1224|Proteobacteria,2TV17@28211|Alphaproteobacteria,2KIPW@204458|Caulobacterales	204458|Caulobacterales	L	DDE domain	-	-	-	ko:K07498	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS240
SHD2_k127_4602745_126	1205680.CAKO01000030_gene4866	1.204e-38	151.0	2CPI3@1|root,32SJ7@2|Bacteria,1N1IR@1224|Proteobacteria,2UBVS@28211|Alphaproteobacteria,2JX60@204441|Rhodospirillales	204441|Rhodospirillales	S	Protein of unknown function (DUF992)	-	-	-	-	-	-	-	-	-	-	-	-	DUF992
SHD2_k127_4602745_173	316058.RPB_0055	9.702e-16	89.0	2DE4Z@1|root,2ZKI5@2|Bacteria,1RCRV@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_4602745_77	1161401.ASJA01000008_gene1610	8.008e-80	274.0	COG0784@1|root,COG0784@2|Bacteria,1MX3Y@1224|Proteobacteria,2TT2R@28211|Alphaproteobacteria,43WD0@69657|Hyphomonadaceae	28211|Alphaproteobacteria	T	response regulator	phyR	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Sigma70_r4_2
SHD2_k127_4602745_172	366602.Caul_4398	4.189e-16	86.0	COG4520@1|root,COG5455@1|root,COG4520@2|Bacteria,COG5455@2|Bacteria	2|Bacteria	D	response to cobalt ion	yohN	GO:0003674,GO:0005488,GO:0005507,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0010033,GO:0010035,GO:0010038,GO:0010045,GO:0010243,GO:0030288,GO:0030313,GO:0031975,GO:0032025,GO:0033554,GO:0042221,GO:0042597,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:1901652,GO:1901698,GO:1901700	-	-	-	-	-	-	-	-	-	-	17kDa_Anti_2,Gly-zipper_Omp,RcnB,Rick_17kDa_Anti
SHD2_k127_4602745_154	1380394.JADL01000001_gene2131	3.385e-24	104.0	28RSH@1|root,2ZE4X@2|Bacteria,1P7EV@1224|Proteobacteria,2UWD5@28211|Alphaproteobacteria,2JY1W@204441|Rhodospirillales	204441|Rhodospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_4602745_174	876269.ARWA01000001_gene2092	2.155e-15	78.0	COG3237@1|root,COG3237@2|Bacteria	2|Bacteria	K	CsbD-like	-	-	-	-	-	-	-	-	-	-	-	-	CsbD
SHD2_k127_4602745_144	1282360.ABAC460_22810	1.873e-29	119.0	COG2261@1|root,COG2261@2|Bacteria,1N72Y@1224|Proteobacteria,2UFM5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	PFAM Transglycosylase-associated protein	MA20_19350	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
SHD2_k127_4602745_80	1419583.V466_22575	1.115e-76	260.0	COG2930@1|root,COG2930@2|Bacteria,1RAIB@1224|Proteobacteria,1S5B7@1236|Gammaproteobacteria,1YS5F@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	S	Twin-arginine translocation pathway signal protein	-	-	-	-	-	-	-	-	-	-	-	-	Ysc84
SHD2_k127_4602745_155	1122604.JONR01000055_gene4108	1.189e-23	112.0	COG5455@1|root,COG5455@2|Bacteria,1PTTS@1224|Proteobacteria,1SVHA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Nickel/cobalt transporter regulator	-	-	-	-	-	-	-	-	-	-	-	-	RcnB
SHD2_k127_4602745_105	402881.Plav_0053	1.101e-49	186.0	COG1595@1|root,COG1595@2|Bacteria,1MZMC@1224|Proteobacteria,2TUUZ@28211|Alphaproteobacteria,1JNVF@119043|Rhodobiaceae	28211|Alphaproteobacteria	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
SHD2_k127_4602745_181	1380391.JIAS01000015_gene356	1.788e-08	62.0	2A359@1|root,30RKG@2|Bacteria,1Q85W@1224|Proteobacteria,2UVE2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_4602745_72	570967.JMLV01000005_gene60	7.071e-88	298.0	COG0664@1|root,COG0664@2|Bacteria,1MV7G@1224|Proteobacteria,2U1I4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Transcriptional regulator, Crp Fnr family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
SHD2_k127_4602745_68	395964.KE386496_gene323	5.486e-89	301.0	COG0664@1|root,COG0664@2|Bacteria,1NEQM@1224|Proteobacteria,2U1CS@28211|Alphaproteobacteria,3NBI4@45404|Beijerinckiaceae	28211|Alphaproteobacteria	K	Crp-like helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
SHD2_k127_4602745_184	626418.bglu_2g07020	3.609e-07	56.0	COG3237@1|root,COG3237@2|Bacteria,1NGW6@1224|Proteobacteria,2WAAJ@28216|Betaproteobacteria,1KAF1@119060|Burkholderiaceae	28216|Betaproteobacteria	S	CsbD-like	-	-	-	-	-	-	-	-	-	-	-	-	CsbD
SHD2_k127_4602745_104	204669.Acid345_3971	5.346e-50	184.0	2ADQJ@1|root,313FX@2|Bacteria,3Y7U5@57723|Acidobacteria,2JN16@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_4602745_3	395965.Msil_0611	0.0	1260.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2TRZD@28211|Alphaproteobacteria,3NAI0@45404|Beijerinckiaceae	28211|Alphaproteobacteria	P	Cation transporter/ATPase, N-terminus	mgtA	-	3.6.3.2	ko:K01531	-	-	-	-	ko00000,ko01000	3.A.3.4	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
SHD2_k127_4602745_188	1224746.B932_2559	0.0003132	49.0	COG2885@1|root,COG2885@2|Bacteria	2|Bacteria	M	chlorophyll binding	coxB	-	1.9.3.1	ko:K02275,ko:K03640	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000,ko02000	2.C.1.2,3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM,Cytochrome_CBB3,OmpA
SHD2_k127_4602745_121	395964.KE386496_gene319	4.754e-41	159.0	COG4420@1|root,COG4420@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1003)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1003
SHD2_k127_4602745_177	266117.Rxyl_2225	1.845e-13	74.0	COG2826@1|root,COG2826@2|Bacteria,2GMZX@201174|Actinobacteria,4CPXZ@84995|Rubrobacteria	84995|Rubrobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_38,rve
SHD2_k127_4602745_112	1211115.ALIQ01000055_gene2819	4.036e-44	162.0	COG0234@1|root,COG0234@2|Bacteria,1MZ2X@1224|Proteobacteria,2U9AQ@28211|Alphaproteobacteria,3NBCP@45404|Beijerinckiaceae	28211|Alphaproteobacteria	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	-	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
SHD2_k127_4602745_8	1411123.JQNH01000001_gene477	3.521e-262	816.0	COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,2TS07@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
SHD2_k127_4602745_162	114615.BRADO3674	2.962e-20	96.0	2DDX0@1|root,32U27@2|Bacteria,1N2PV@1224|Proteobacteria,2U67F@28211|Alphaproteobacteria,3JYJV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_4602745_71	196490.AUEZ01000055_gene235	5.551e-88	294.0	2AUXR@1|root,2ZBPW@2|Bacteria,1RAID@1224|Proteobacteria,2U6KV@28211|Alphaproteobacteria,3JYM4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_4602745_187	158500.BV97_03460	5.686e-06	53.0	2CI73@1|root,2ZG30@2|Bacteria,1NKAR@1224|Proteobacteria,2UJRH@28211|Alphaproteobacteria,2KBV8@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_4602745_171	1522072.IL54_1823	3.261e-16	79.0	COG5403@1|root,COG5403@2|Bacteria,1N0H4@1224|Proteobacteria,2UBXP@28211|Alphaproteobacteria,2K5C1@204457|Sphingomonadales	204457|Sphingomonadales	S	Bacterial protein of unknown function (DUF937)	-	-	-	-	-	-	-	-	-	-	-	-	DUF937
SHD2_k127_4602745_151	1230476.C207_05824	3.259e-26	111.0	2DNGD@1|root,32XCZ@2|Bacteria,1RJW1@1224|Proteobacteria,2U9RF@28211|Alphaproteobacteria,3JZJE@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_4602745_134	1172188.KB911822_gene793	2.051e-35	137.0	2ADBR@1|root,31316@2|Bacteria,2IR2Y@201174|Actinobacteria,4FHHF@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF2853)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2853
SHD2_k127_4602745_73	765913.ThidrDRAFT_2214	7.373e-88	298.0	COG2321@1|root,COG2321@2|Bacteria,1MU4U@1224|Proteobacteria,1RMF8@1236|Gammaproteobacteria,1WVZR@135613|Chromatiales	135613|Chromatiales	S	Putative neutral zinc metallopeptidase	-	-	-	ko:K07054	-	-	-	-	ko00000	-	-	-	Zn_peptidase
SHD2_k127_4602745_149	760192.Halhy_6117	2.724e-27	121.0	COG0726@1|root,COG0726@2|Bacteria,4NJK7@976|Bacteroidetes,1IS5R@117747|Sphingobacteriia	976|Bacteroidetes	G	COGs COG0726 xylanase chitin deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
SHD2_k127_4602745_140	570967.JMLV01000003_gene2172	3.08e-32	135.0	COG4731@1|root,COG4731@2|Bacteria,1N7E7@1224|Proteobacteria,2UHSI@28211|Alphaproteobacteria,2JXGY@204441|Rhodospirillales	204441|Rhodospirillales	S	Uncharacterized protein conserved in bacteria (DUF2147)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2147
SHD2_k127_4602745_183	1121123.AUAO01000001_gene784	3.356e-07	53.0	COG3316@1|root,COG3316@2|Bacteria,1P9SM@1224|Proteobacteria,2TV17@28211|Alphaproteobacteria,2KIPW@204458|Caulobacterales	204458|Caulobacterales	L	DDE domain	-	-	-	ko:K07498	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS240
SHD2_k127_4602745_165	420324.KI911943_gene5252	8.651e-20	94.0	COG3316@1|root,COG3316@2|Bacteria,1P9SM@1224|Proteobacteria,2TV17@28211|Alphaproteobacteria,1JY3D@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	DDE domain	-	-	-	ko:K07498	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS240
SHD2_k127_4602745_115	1280947.HY30_06460	7.169e-43	162.0	COG1959@1|root,COG1959@2|Bacteria,1RDA4@1224|Proteobacteria,2U5B9@28211|Alphaproteobacteria,43Y37@69657|Hyphomonadaceae	28211|Alphaproteobacteria	K	Transcriptional regulator	iscR	-	-	ko:K13643	-	-	-	-	ko00000,ko03000	-	-	-	Rrf2
SHD2_k127_4602745_53	196367.JNFG01000002_gene2265	2.379e-119	397.0	COG1960@1|root,COG1960@2|Bacteria,1P7WH@1224|Proteobacteria,2VMPJ@28216|Betaproteobacteria,1K4I6@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M
SHD2_k127_4602745_35	1245471.PCA10_29470	7.36e-159	511.0	COG0183@1|root,COG0183@2|Bacteria,1MU8C@1224|Proteobacteria,1S0KG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Thiolase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Thiolase_C,Thiolase_N
SHD2_k127_4602745_22	748247.AZKH_1894	1.199e-195	625.0	COG0318@1|root,COG0318@2|Bacteria,1MWSD@1224|Proteobacteria,2VHE3@28216|Betaproteobacteria,2KYPH@206389|Rhodocyclales	206389|Rhodocyclales	IQ	AMP-binding enzyme	-	-	6.2.1.48	ko:K02182	-	-	-	-	ko00000,ko01000	-	-	-	AMP-binding,AMP-binding_C
SHD2_k127_4602745_101	96561.Dole_0116	2.47e-53	197.0	COG0778@1|root,COG0778@2|Bacteria,1RECN@1224|Proteobacteria,42SPP@68525|delta/epsilon subdivisions,2WPPZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
SHD2_k127_4602745_185	767817.Desgi_4108	4.012e-06	53.0	COG4231@1|root,COG4231@2|Bacteria,1UN0W@1239|Firmicutes,25GU2@186801|Clostridia,267H6@186807|Peptococcaceae	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
SHD2_k127_4602745_26	709797.CSIRO_0738	3.822e-184	583.0	COG0604@1|root,COG0604@2|Bacteria,1MW2V@1224|Proteobacteria,2U07M@28211|Alphaproteobacteria,3JQSM@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
SHD2_k127_4602745_5	1429916.X566_23475	0.0	1024.0	COG2072@1|root,COG2072@2|Bacteria,1NSY9@1224|Proteobacteria,2TUSD@28211|Alphaproteobacteria,3JUMD@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Flavin-binding monooxygenase-like	MA20_26775	-	1.14.13.22	ko:K03379	ko00930,ko01120,ko01220,map00930,map01120,map01220	-	R02231,R06622	RC00662,RC01550	ko00000,ko00001,ko01000	-	-	-	NAD_binding_8,Pyr_redox_2,Pyr_redox_3
SHD2_k127_4602745_179	1282876.BAOK01000001_gene1946	9.434e-11	71.0	COG0790@1|root,COG0790@2|Bacteria,1PAYM@1224|Proteobacteria,2UWKF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	COG0790 FOG TPR repeat, SEL1 subfamily	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_4602745_41	402881.Plav_2693	8.4e-149	479.0	COG1902@1|root,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,2TQPY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	NADH flavin oxidoreductase NADH oxidase	-	-	1.5.8.1,1.5.8.2	ko:K00317,ko:K21833	ko00680,ko01120,ko01200,map00680,map01120,map01200	-	R01588,R02511	RC00185,RC00556,RC00557,RC00732	ko00000,ko00001,ko01000	-	-	-	Oxidored_FMN,Pyr_redox_2
SHD2_k127_4602745_12	1144307.PMI04_03355	1.628e-221	702.0	COG0028@1|root,COG0028@2|Bacteria,1MXDW@1224|Proteobacteria,2TT9X@28211|Alphaproteobacteria,2K2ZU@204457|Sphingomonadales	28211|Alphaproteobacteria	EH	PFAM Thiamine pyrophosphate enzyme, central domain, Thiamine pyrophosphate enzyme, N-terminal TPP binding domain, Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
SHD2_k127_4602745_9	1205680.CAKO01000038_gene1795	3.335e-257	801.0	COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2TQU2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	acyl-CoA dehydrogenase	aidB	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003995,GO:0005488,GO:0005515,GO:0006355,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008470,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016491,GO:0016627,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0033554,GO:0042802,GO:0043565,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0055114,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	ko:K09456	-	-	-	-	ko00000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M
SHD2_k127_4602745_18	225937.HP15_4138	7.269e-199	634.0	COG0277@1|root,COG0277@2|Bacteria,1MXTV@1224|Proteobacteria,1RRN8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	COG0277 FAD FMN-containing dehydrogenases	ygcU	-	2.5.1.26	ko:K00803	ko00565,ko01100,ko04146,map00565,map01100,map04146	-	R04311	RC00020,RC02886	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
SHD2_k127_4602745_85	1502851.FG93_01696	8.864e-71	249.0	COG2267@1|root,COG2267@2|Bacteria,1MYEX@1224|Proteobacteria,2U5YK@28211|Alphaproteobacteria,3K1PM@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Serine aminopeptidase, S33	-	-	3.4.11.5	ko:K01259	ko00330,map00330	-	R00135	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Abhydrolase_1
SHD2_k127_4602745_64	1205680.CAKO01000037_gene1327	3.569e-97	325.0	COG1024@1|root,COG1024@2|Bacteria,1PJ4R@1224|Proteobacteria,2TSSU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	MA20_16345	-	-	-	-	-	-	-	-	-	-	-	ECH_1
SHD2_k127_4602745_133	1449049.JONW01000007_gene3856	1.143e-35	139.0	COG3245@1|root,COG3245@2|Bacteria,1Q2SM@1224|Proteobacteria,2UJ17@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
SHD2_k127_4602745_13	59538.XP_005957140.1	1.794e-220	692.0	COG0277@1|root,KOG4730@2759|Eukaryota,38E7K@33154|Opisthokonta,3BJIG@33208|Metazoa,3CZHH@33213|Bilateria,48BJM@7711|Chordata,493Z7@7742|Vertebrata,3J7T0@40674|Mammalia,4J1WA@91561|Cetartiodactyla	33154|Opisthokonta	V	L-gulonolactone oxidase-like	-	-	1.1.3.8,1.3.2.3	ko:K00103,ko:K00225	ko00053,ko01100,ko01110,map00053,map01100,map01110	M00114,M00129	R00640,R00647,R03184,R07679,R10053	RC00092,RC00195,RC00346,RC00869	ko00000,ko00001,ko00002,ko01000	-	-	-	ALO,FAD_binding_4
SHD2_k127_4602745_11	497321.C664_17542	3e-231	723.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2VHGR@28216|Betaproteobacteria,2KUI9@206389|Rhodocyclales	206389|Rhodocyclales	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.16,1.2.1.20,1.2.1.79	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	M00027	R00713,R00714,R02401	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
SHD2_k127_4602745_170	991905.SL003B_1654	2.625e-17	91.0	2E6CF@1|root,33106@2|Bacteria,1NN61@1224|Proteobacteria,2UHRW@28211|Alphaproteobacteria,4BSW0@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_4602745_50	935863.AWZR01000002_gene1099	1.417e-121	402.0	COG0667@1|root,COG0667@2|Bacteria,1MVEH@1224|Proteobacteria,1RPX5@1236|Gammaproteobacteria,1X56H@135614|Xanthomonadales	135614|Xanthomonadales	C	oxidoreductases (related to aryl-alcohol dehydrogenases)	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
SHD2_k127_4602745_16	864069.MicloDRAFT_00008900	1.442e-201	639.0	COG0397@1|root,COG0397@2|Bacteria,1MVK3@1224|Proteobacteria,2TT84@28211|Alphaproteobacteria,1JS3J@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Belongs to the UPF0061 (SELO) family	MA20_28420	-	-	ko:K08997	-	-	-	-	ko00000	-	-	-	UPF0061
SHD2_k127_4602745_60	237368.SCABRO_00902	3.112e-103	349.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	ko:K08218	ko01501,map01501	M00628	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.25	-	-	MFS_1
SHD2_k127_4602745_63	366602.Caul_0517	4.153e-100	344.0	COG2211@1|root,COG2211@2|Bacteria,1MVUM@1224|Proteobacteria,2U1DI@28211|Alphaproteobacteria,2KFG7@204458|Caulobacterales	204458|Caulobacterales	G	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_2
SHD2_k127_4602745_59	190650.CC_1748	5.552e-107	368.0	COG2211@1|root,COG2211@2|Bacteria,1MVUM@1224|Proteobacteria,2U1DI@28211|Alphaproteobacteria,2KFG7@204458|Caulobacterales	204458|Caulobacterales	G	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_2
SHD2_k127_4602745_90	450851.PHZ_c0753	8.399e-62	218.0	COG1309@1|root,COG1309@2|Bacteria,1RHEM@1224|Proteobacteria,2UDIZ@28211|Alphaproteobacteria,2KIKR@204458|Caulobacterales	204458|Caulobacterales	K	WHG domain	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N,WHG
SHD2_k127_4602745_15	450851.PHZ_c0754	3.146e-205	649.0	COG3670@1|root,COG3670@2|Bacteria,1MY1X@1224|Proteobacteria,2TS7A@28211|Alphaproteobacteria,2KG2S@204458|Caulobacterales	204458|Caulobacterales	Q	dioxygenase	-	-	-	ko:K11159	-	-	-	-	ko00000	-	-	-	RPE65
SHD2_k127_4602745_69	1382303.JPOM01000001_gene2431	1.224e-88	308.0	COG1409@1|root,COG1409@2|Bacteria,1R8W7@1224|Proteobacteria,2U64B@28211|Alphaproteobacteria,2KIPZ@204458|Caulobacterales	204458|Caulobacterales	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
SHD2_k127_4602745_1	1279038.KB907344_gene3660	0.0	1296.0	COG2373@1|root,COG2373@2|Bacteria,1MV7J@1224|Proteobacteria,2TSAE@28211|Alphaproteobacteria,2JPP9@204441|Rhodospirillales	204441|Rhodospirillales	S	Alpha-2-Macroglobulin	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,MG1,PAN_1,Thiol-ester_cl
SHD2_k127_4602745_30	395964.KE386496_gene681	2.17e-174	570.0	COG4953@1|root,COG4953@2|Bacteria,1MUA9@1224|Proteobacteria,2TR2R@28211|Alphaproteobacteria,3NA2Z@45404|Beijerinckiaceae	28211|Alphaproteobacteria	M	Penicillin-Binding Protein C-terminus Family	pbpC	-	2.4.1.129	ko:K05367	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	BiPBP_C,Transgly,Transpeptidase
SHD2_k127_4602745_178	290399.Arth_3903	9.935e-12	73.0	COG2764@1|root,COG2764@2|Bacteria,2I2KY@201174|Actinobacteria,1WCE4@1268|Micrococcaceae	201174|Actinobacteria	S	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
SHD2_k127_4602745_61	402881.Plav_2020	7.242e-101	344.0	COG0477@1|root,COG2814@2|Bacteria,1MVSC@1224|Proteobacteria,2TXB0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EGP	COG0477 Permeases of the major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
SHD2_k127_4602745_54	1206777.B195_13136	4.856e-113	381.0	COG2951@1|root,COG3409@1|root,COG2951@2|Bacteria,COG3409@2|Bacteria,1MUZ3@1224|Proteobacteria,1RMQ6@1236|Gammaproteobacteria,1Z680@136849|Pseudomonas syringae group	1236|Gammaproteobacteria	M	Not a type III effector	-	-	-	ko:K08305	-	-	-	-	ko00000,ko01000,ko01011	-	GH103	-	PG_binding_1,SLT_2
SHD2_k127_4602745_175	1238182.C882_2744	3.02e-15	76.0	COG0257@1|root,COG0257@2|Bacteria,1NGBJ@1224|Proteobacteria,2UJAG@28211|Alphaproteobacteria,2JUHJ@204441|Rhodospirillales	204441|Rhodospirillales	J	Belongs to the bacterial ribosomal protein bL36 family	rpmJ	-	-	ko:K02919	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L36
SHD2_k127_4602745_24	392499.Swit_0991	1.065e-190	607.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2TSG6@28211|Alphaproteobacteria,2K2GG@204457|Sphingomonadales	204457|Sphingomonadales	C	FAD linked oxidases, C-terminal domain	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
SHD2_k127_4602745_76	414684.RC1_2151	3.301e-82	289.0	COG0277@1|root,COG0277@2|Bacteria,1MVYV@1224|Proteobacteria,2TRA7@28211|Alphaproteobacteria,2JPFB@204441|Rhodospirillales	204441|Rhodospirillales	C	FAD binding domain	glcE	-	-	ko:K11472	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	FAD-oxidase_C,FAD_binding_4
SHD2_k127_4602745_52	1121861.KB899920_gene2908	7.534e-120	401.0	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,2TR9H@28211|Alphaproteobacteria,2JPXJ@204441|Rhodospirillales	204441|Rhodospirillales	C	Cysteine-rich domain	glcF	-	-	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	CCG,Fer4_7,Fer4_8
SHD2_k127_4602745_152	1120792.JAFV01000001_gene2623	4.148e-26	114.0	COG0457@1|root,COG0457@2|Bacteria,1N0DE@1224|Proteobacteria,2UCGA@28211|Alphaproteobacteria,36YRK@31993|Methylocystaceae	28211|Alphaproteobacteria	S	COG0457 FOG TPR repeat	MA20_05980	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2,TPR_6,TPR_8
SHD2_k127_4602745_21	402881.Plav_2030	1.077e-195	620.0	COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,2TRFV@28211|Alphaproteobacteria,1JN7C@119043|Rhodobiaceae	28211|Alphaproteobacteria	G	Pyruvate kinase, alpha/beta domain	pyk	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
SHD2_k127_4602745_146	311402.Avi_3691	2.159e-27	116.0	COG5480@1|root,COG5480@2|Bacteria,1RISQ@1224|Proteobacteria,2U9NW@28211|Alphaproteobacteria,4BAS0@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	integral membrane protein	MA20_03870	-	-	-	-	-	-	-	-	-	-	-	DUF1036
SHD2_k127_4602745_79	1125973.JNLC01000013_gene3813	7.676e-77	270.0	COG3931@1|root,COG3931@2|Bacteria,1QI71@1224|Proteobacteria,2TVK6@28211|Alphaproteobacteria,3JTTE@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	N-formylglutamate amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	FGase
SHD2_k127_4602745_141	402881.Plav_2033	4.263e-32	139.0	COG3492@1|root,COG3492@2|Bacteria,1MZ3I@1224|Proteobacteria,2UC11@28211|Alphaproteobacteria,1JP6H@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1244)	MA20_03865	-	-	ko:K09948	-	-	-	-	ko00000	-	-	-	DUF1244
SHD2_k127_4602745_147	1082931.KKY_2514	2.168e-27	112.0	COG3750@1|root,COG3750@2|Bacteria,1N77J@1224|Proteobacteria,2UFX6@28211|Alphaproteobacteria,3N7B0@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Belongs to the UPF0335 family	MA20_03860	-	-	-	-	-	-	-	-	-	-	-	DUF2312
SHD2_k127_4602745_19	1282876.BAOK01000001_gene1012	9.431e-199	631.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2TQPG@28211|Alphaproteobacteria,4BR8G@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	T	Sigma-54 interaction domain	tacA	GO:0003674,GO:0003700,GO:0004857,GO:0006355,GO:0008073,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0010967,GO:0019219,GO:0019222,GO:0030234,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0033238,GO:0042979,GO:0043086,GO:0044092,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0065009,GO:0080090,GO:0098772,GO:0140110,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activ_2,Sigma54_activat
SHD2_k127_4602745_91	198094.BA_2973	4.489e-61	223.0	COG4427@1|root,COG4427@2|Bacteria,1TZ5M@1239|Firmicutes,4HAQV@91061|Bacilli,1ZCQX@1386|Bacillus	91061|Bacilli	S	Uncharacterized protein conserved in bacteria (DUF2332)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2332
SHD2_k127_4602745_93	1333998.M2A_2156	5.708e-61	213.0	COG2050@1|root,COG2050@2|Bacteria,1RJ7W@1224|Proteobacteria,2UAFZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Thioesterase	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
SHD2_k127_4602745_40	402881.Plav_2055	3.202e-150	482.0	COG2267@1|root,COG2267@2|Bacteria,1PFU6@1224|Proteobacteria,2V8R5@28211|Alphaproteobacteria,1JPU4@119043|Rhodobiaceae	28211|Alphaproteobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
SHD2_k127_4602745_34	1380391.JIAS01000015_gene83	2.29e-159	510.0	COG3288@1|root,COG3288@2|Bacteria,1MVXU@1224|Proteobacteria,2TSZN@28211|Alphaproteobacteria,2JPDV@204441|Rhodospirillales	204441|Rhodospirillales	C	transhydrogenase subunit alpha	pntAA	GO:0000166,GO:0003674,GO:0003824,GO:0003957,GO:0005215,GO:0005488,GO:0005515,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006740,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0008746,GO:0008750,GO:0009117,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015672,GO:0016491,GO:0016651,GO:0016652,GO:0019362,GO:0019637,GO:0022857,GO:0022890,GO:0034220,GO:0034641,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0046496,GO:0046983,GO:0048037,GO:0050662,GO:0051179,GO:0051186,GO:0051234,GO:0051287,GO:0055085,GO:0055086,GO:0055114,GO:0070403,GO:0070404,GO:0071704,GO:0072524,GO:0097159,GO:0098655,GO:0098660,GO:0098662,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1902600	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
SHD2_k127_4602745_123	314254.OA2633_07949	4.609e-40	151.0	COG3288@1|root,COG3288@2|Bacteria,1MZ3E@1224|Proteobacteria,2UBXS@28211|Alphaproteobacteria,43Y9Z@69657|Hyphomonadaceae	28211|Alphaproteobacteria	C	NADP transhydrogenase	pntAB	GO:0008150,GO:0008152,GO:0055114	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB_4TM
SHD2_k127_4602745_14	450851.PHZ_c3101	3.008e-218	685.0	COG1282@1|root,COG1282@2|Bacteria,1MUP4@1224|Proteobacteria,2TQN1@28211|Alphaproteobacteria,2KFJ5@204458|Caulobacterales	204458|Caulobacterales	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	-	-	1.6.1.2	ko:K00325	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB
SHD2_k127_4602745_120	402881.Plav_2062	3.885e-41	154.0	2A0NG@1|root,32XDJ@2|Bacteria,1N3J7@1224|Proteobacteria,2UD9K@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_4602745_100	1429916.X566_09650	8.059e-57	202.0	COG2947@1|root,COG2947@2|Bacteria,1RHRU@1224|Proteobacteria,2U71N@28211|Alphaproteobacteria,3JY7K@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	EVE domain	MA20_25125	-	-	-	-	-	-	-	-	-	-	-	EVE
SHD2_k127_4602745_158	402881.Plav_1342	3.767e-23	101.0	COG2350@1|root,COG2350@2|Bacteria,1MZ9Z@1224|Proteobacteria,2UF4X@28211|Alphaproteobacteria,1JQIH@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	YCII-related domain	yciI	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K09780	-	-	-	-	ko00000	-	-	-	YCII
SHD2_k127_4602745_62	991905.SL003B_0372	3.765e-100	337.0	COG0240@1|root,COG0240@2|Bacteria,1MUU3@1224|Proteobacteria,2TT75@28211|Alphaproteobacteria,4BP8N@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	PFAM NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus	gpsA	GO:0003674,GO:0003824,GO:0006072,GO:0006629,GO:0006644,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0047952,GO:0052646,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
SHD2_k127_4602745_98	402881.Plav_1344	1.129e-57	210.0	COG1309@1|root,COG1309@2|Bacteria,1N71J@1224|Proteobacteria,2UHJN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
SHD2_k127_4602745_128	402881.Plav_1299	1.685e-36	146.0	COG2834@1|root,COG2834@2|Bacteria,1RA1S@1224|Proteobacteria,2U58W@28211|Alphaproteobacteria,1JP6J@119043|Rhodobiaceae	28211|Alphaproteobacteria	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	lolA	-	-	-	-	-	-	-	-	-	-	-	LolA
SHD2_k127_4602745_67	287.DR97_3259	9.891e-90	301.0	COG2071@1|root,COG2071@2|Bacteria,1MV8E@1224|Proteobacteria,1RS51@1236|Gammaproteobacteria,1YD0Y@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	Peptidase C26	spuA	-	-	ko:K07010	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_C26
SHD2_k127_4602745_122	1122604.JONR01000074_gene720	2.418e-40	151.0	COG0640@1|root,COG0640@2|Bacteria,1RHCK@1224|Proteobacteria,1SG51@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
SHD2_k127_4602745_92	1122604.JONR01000074_gene721	5.151e-61	215.0	COG3832@1|root,COG3832@2|Bacteria,1RAW4@1224|Proteobacteria	1224|Proteobacteria	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
SHD2_k127_4602745_118	588932.JHOF01000024_gene86	1.16e-41	160.0	COG3832@1|root,COG3832@2|Bacteria,1N2PR@1224|Proteobacteria,2VGJB@28211|Alphaproteobacteria,2KJ19@204458|Caulobacterales	204458|Caulobacterales	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
SHD2_k127_4602745_27	402881.Plav_1296	6.46e-181	578.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2TQND@28211|Alphaproteobacteria,1JMYE@119043|Rhodobiaceae	28211|Alphaproteobacteria	H	Aminotransferase class-III	bioA	-	2.6.1.113	ko:K12256	ko00330,ko01100,map00330,map01100	-	R08714	RC00008,RC00062	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_3
SHD2_k127_4602745_82	1211115.ALIQ01000214_gene136	1.98e-76	263.0	COG3145@1|root,COG3145@2|Bacteria,1N5HB@1224|Proteobacteria,2U5C6@28211|Alphaproteobacteria,3NB19@45404|Beijerinckiaceae	28211|Alphaproteobacteria	L	2OG-Fe(II) oxygenase superfamily	alkB	-	1.14.11.33	ko:K03919	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	2OG-FeII_Oxy_2
SHD2_k127_4602745_167	1122614.JHZF01000013_gene3033	5.708e-19	96.0	COG2365@1|root,COG2365@2|Bacteria,1REIM@1224|Proteobacteria,2U7HD@28211|Alphaproteobacteria,2PEDH@252301|Oceanicola	28211|Alphaproteobacteria	T	COG2365 Protein tyrosine serine phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	DUF442,Y_phosphatase3
SHD2_k127_4602745_138	1254432.SCE1572_45530	5.498e-33	130.0	COG0261@1|root,COG0261@2|Bacteria,1MZEW@1224|Proteobacteria,42SGM@68525|delta/epsilon subdivisions,2WQ3I@28221|Deltaproteobacteria,2YVHC@29|Myxococcales	28221|Deltaproteobacteria	J	This protein binds to 23S rRNA in the presence of protein L20	rplU	GO:0003674,GO:0003735,GO:0005198	-	ko:K02888	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21p
SHD2_k127_4602745_131	34007.IT40_11530	3.803e-36	139.0	COG0211@1|root,COG0211@2|Bacteria,1MZGH@1224|Proteobacteria,2UBUX@28211|Alphaproteobacteria,2PXHQ@265|Paracoccus	28211|Alphaproteobacteria	J	Belongs to the bacterial ribosomal protein bL27 family	rpmA	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
SHD2_k127_4602745_137	402881.Plav_1481	2.519e-33	136.0	COG1670@1|root,COG1670@2|Bacteria,1N6Q1@1224|Proteobacteria,2UG72@28211|Alphaproteobacteria,1JPI1@119043|Rhodobiaceae	28211|Alphaproteobacteria	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
SHD2_k127_4602745_150	1090320.KB900605_gene2162	1.544e-26	119.0	COG1670@1|root,COG1670@2|Bacteria,1N6Q1@1224|Proteobacteria,2UG72@28211|Alphaproteobacteria,2K7NM@204457|Sphingomonadales	204457|Sphingomonadales	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
SHD2_k127_4602745_99	1041146.ATZB01000020_gene3772	2.839e-57	209.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,rRNA_methylase
SHD2_k127_4602745_43	195105.CN97_06930	1.041e-144	470.0	COG0536@1|root,COG0536@2|Bacteria,1MUGZ@1224|Proteobacteria,2TR5I@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	GTP1_OBG,MMR_HSR1
SHD2_k127_4602745_46	1110502.TMO_2968	1.243e-134	444.0	COG0263@1|root,COG0263@2|Bacteria,1MUBG@1224|Proteobacteria,2TRKB@28211|Alphaproteobacteria,2JPD3@204441|Rhodospirillales	204441|Rhodospirillales	E	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate	proB	-	2.7.2.11	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	M00015	R00239	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,PUA
SHD2_k127_4602745_36	876269.ARWA01000001_gene3733	1.069e-158	511.0	COG0014@1|root,COG0014@2|Bacteria,1MUGJ@1224|Proteobacteria,2TS83@28211|Alphaproteobacteria,3NAKC@45404|Beijerinckiaceae	28211|Alphaproteobacteria	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate	proA	GO:0003674,GO:0003824,GO:0004350,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
SHD2_k127_4602745_103	1121033.AUCF01000011_gene1856	6.559e-52	197.0	COG1057@1|root,COG1057@2|Bacteria,1RD0J@1224|Proteobacteria,2U6ZC@28211|Alphaproteobacteria,2JSCY@204441|Rhodospirillales	204441|Rhodospirillales	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	-	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
SHD2_k127_4602745_127	1333998.M2A_0820	1.562e-36	143.0	COG0799@1|root,COG0799@2|Bacteria,1MZEF@1224|Proteobacteria,2UBSV@28211|Alphaproteobacteria,4BQRD@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	J	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation	rsfS	-	-	ko:K09710	-	-	-	-	ko00000,ko03009	-	-	-	RsfS
SHD2_k127_4602745_132	631454.N177_1847	3.854e-36	142.0	COG1576@1|root,COG1576@2|Bacteria,1R9Z2@1224|Proteobacteria,2U95Q@28211|Alphaproteobacteria,1JPA6@119043|Rhodobiaceae	28211|Alphaproteobacteria	J	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA	rlmH	-	2.1.1.177	ko:K00783	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SPOUT_MTase
SHD2_k127_4602745_164	414684.RC1_1392	4.293e-20	96.0	2E5SK@1|root,330GZ@2|Bacteria,1N7R1@1224|Proteobacteria,2UFAX@28211|Alphaproteobacteria,2JTWZ@204441|Rhodospirillales	204441|Rhodospirillales	N	Class II flagellar assembly regulator	fliX	-	-	-	-	-	-	-	-	-	-	-	FliX
SHD2_k127_4602745_37	1040989.AWZU01000036_gene7242	1.733e-157	507.0	COG0508@1|root,COG0508@2|Bacteria,1MUJD@1224|Proteobacteria,2TS5N@28211|Alphaproteobacteria,3JR1I@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2)	sucB	-	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
SHD2_k127_4602745_2	402881.Plav_1454	0.0	1294.0	COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,2TRBQ@28211|Alphaproteobacteria,1JN55@119043|Rhodobiaceae	28211|Alphaproteobacteria	C	2-oxoglutarate dehydrogenase, E1	sucA	-	1.2.4.2	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
SHD2_k127_4602745_89	1121022.ABENE_00245	3.94e-64	234.0	COG1835@1|root,COG1835@2|Bacteria,1R8PB@1224|Proteobacteria,2U1NT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
SHD2_k127_4602745_156	1037409.BJ6T_41630	2.059e-23	108.0	COG2050@1|root,COG2050@2|Bacteria,1RFCZ@1224|Proteobacteria,2U8Z5@28211|Alphaproteobacteria,3JZ5P@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Domain of unknown function (DUF4442)	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
SHD2_k127_4602745_39	402881.Plav_1453	1.307e-152	494.0	COG0074@1|root,COG0074@2|Bacteria,1MUGA@1224|Proteobacteria,2TQKB@28211|Alphaproteobacteria,1JMYX@119043|Rhodobiaceae	28211|Alphaproteobacteria	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA
SHD2_k127_4602745_25	1282876.BAOK01000002_gene450	8.448e-189	598.0	COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,2TRXK@28211|Alphaproteobacteria,4BPP4@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	GO:0003674,GO:0003824,GO:0004774,GO:0004775,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016874,GO:0016877,GO:0016878,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
SHD2_k127_4602745_111	1500259.JQLD01000001_gene3678	2.507e-44	173.0	COG0671@1|root,COG0671@2|Bacteria,1RF9P@1224|Proteobacteria,2U7X9@28211|Alphaproteobacteria,4BANM@82115|Rhizobiaceae	28211|Alphaproteobacteria	I	PAP2 superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PAP2_3
SHD2_k127_4602745_166	1161401.ASJA01000004_gene2313	9.448e-20	100.0	28Q0K@1|root,2ZCJE@2|Bacteria,1RBF2@1224|Proteobacteria,2U5GG@28211|Alphaproteobacteria,43Y2I@69657|Hyphomonadaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_4602745_88	1207063.P24_07206	9.056e-68	241.0	COG0705@1|root,COG0705@2|Bacteria,1MYFP@1224|Proteobacteria,2TSJG@28211|Alphaproteobacteria,2JRGA@204441|Rhodospirillales	204441|Rhodospirillales	S	Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
SHD2_k127_4602745_163	1535287.JP74_02005	3.508e-20	99.0	COG5388@1|root,COG5388@2|Bacteria,1MXF0@1224|Proteobacteria,2U3WI@28211|Alphaproteobacteria,3N77W@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	PAS domain	MA20_31625	-	-	-	-	-	-	-	-	-	-	-	PAS_5
SHD2_k127_4602745_86	1121127.JAFA01000032_gene4369	3.147e-70	249.0	COG2267@1|root,COG2267@2|Bacteria,1QAWD@1224|Proteobacteria,2WD2M@28216|Betaproteobacteria,1K95H@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
SHD2_k127_4602745_10	1333998.M2A_2545	1.87e-242	759.0	COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,2TQKQ@28211|Alphaproteobacteria,4BR6Q@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	GMC oxidoreductase	betA	-	1.1.99.1	ko:K00108	ko00260,ko01100,map00260,map01100	M00555	R01025	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	GMC_oxred_C,GMC_oxred_N
SHD2_k127_4602745_145	1207063.P24_16697	2.892e-29	130.0	COG2885@1|root,COG2885@2|Bacteria,1RJ3P@1224|Proteobacteria,2U9ZX@28211|Alphaproteobacteria,2JSTE@204441|Rhodospirillales	204441|Rhodospirillales	M	COG2885 Outer membrane protein and related peptidoglycan-associated (lipo)proteins	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
SHD2_k127_4602745_130	631454.N177_2028	2.862e-36	146.0	28I3D@1|root,2Z876@2|Bacteria,1P0DR@1224|Proteobacteria,2TTG2@28211|Alphaproteobacteria,1JPH5@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	PilZ domain	MA20_31715	-	-	-	-	-	-	-	-	-	-	-	PilZ
SHD2_k127_4602745_157	509190.Cseg_3305	2.19e-23	106.0	COG2315@1|root,COG2315@2|Bacteria,1RHEZ@1224|Proteobacteria,2U97K@28211|Alphaproteobacteria,2KH5B@204458|Caulobacterales	204458|Caulobacterales	S	YjbR	-	-	-	-	-	-	-	-	-	-	-	-	YjbR
SHD2_k127_4602745_129	402881.Plav_1386	1.824e-36	149.0	COG3339@1|root,COG3339@2|Bacteria,1MZR5@1224|Proteobacteria,2UCIB@28211|Alphaproteobacteria,1JPCY@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1232)	MA20_25305	-	-	-	-	-	-	-	-	-	-	-	DUF1232
SHD2_k127_4602745_113	1230476.C207_05350	8.469e-44	163.0	COG2050@1|root,COG2050@2|Bacteria,1PP3J@1224|Proteobacteria,2U5E4@28211|Alphaproteobacteria,3JY0G@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Thioesterase superfamily	MA20_28520	-	-	-	-	-	-	-	-	-	-	-	4HBT
SHD2_k127_4602745_49	450851.PHZ_c3494	5.477e-124	402.0	COG1028@1|root,COG1028@2|Bacteria,1MUBQ@1224|Proteobacteria,2TRPN@28211|Alphaproteobacteria,2KFSZ@204458|Caulobacterales	204458|Caulobacterales	IQ	Dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
SHD2_k127_4602745_119	366602.Caul_3176	1.218e-41	159.0	COG0251@1|root,COG0251@2|Bacteria,1RCX5@1224|Proteobacteria,2U74Y@28211|Alphaproteobacteria,2KHF1@204458|Caulobacterales	204458|Caulobacterales	J	Endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
SHD2_k127_4602745_169	526225.Gobs_1852	1.821e-17	89.0	2E4RI@1|root,32ZK2@2|Bacteria,2GTNG@201174|Actinobacteria,4EWHW@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_4602745_0	1449049.JONW01000006_gene2813	0.0	1410.0	COG2902@1|root,COG2902@2|Bacteria,1MXNV@1224|Proteobacteria,2TS89@28211|Alphaproteobacteria,2KFH1@204458|Caulobacterales	204458|Caulobacterales	E	Dehydrogenase	-	-	1.4.1.2	ko:K15371	ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100	-	R00243	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	Bac_GDH
SHD2_k127_4602745_102	1187851.A33M_0001	3.516e-53	190.0	COG3542@1|root,COG3542@2|Bacteria,1RHBE@1224|Proteobacteria,2U962@28211|Alphaproteobacteria,3FD92@34008|Rhodovulum	28211|Alphaproteobacteria	S	Cupin superfamily (DUF985)	MA20_39615	-	-	ko:K09705	-	-	-	-	ko00000	-	-	-	Cupin_5
SHD2_k127_4602745_186	190650.CC_0512	4.092e-06	58.0	2ARAD@1|root,31GKB@2|Bacteria,1RJG7@1224|Proteobacteria,2UBC4@28211|Alphaproteobacteria,2KGQ5@204458|Caulobacterales	204458|Caulobacterales	S	Domain of unknown function (DUF4908)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4908
SHD2_k127_4602745_57	414684.RC1_1463	5.035e-108	355.0	COG1024@1|root,COG1024@2|Bacteria,1NDT7@1224|Proteobacteria,2U2R9@28211|Alphaproteobacteria,2JX5X@204441|Rhodospirillales	204441|Rhodospirillales	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
SHD2_k127_4602745_4	1380391.JIAS01000018_gene900	0.0	1223.0	COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,2TT3T@28211|Alphaproteobacteria,2JQQN@204441|Rhodospirillales	204441|Rhodospirillales	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	acnA	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
SHD2_k127_4602745_114	1449049.JONW01000009_gene4349	1.179e-43	165.0	COG1247@1|root,COG1247@2|Bacteria	2|Bacteria	M	phosphinothricin N-acetyltransferase activity	-	-	-	ko:K03825	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_4
SHD2_k127_4602745_55	402881.Plav_0822	1.329e-108	361.0	COG0583@1|root,COG0583@2|Bacteria,1MWVB@1224|Proteobacteria,2TTFG@28211|Alphaproteobacteria,1JP6D@119043|Rhodobiaceae	28211|Alphaproteobacteria	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
SHD2_k127_4602745_78	543728.Vapar_4687	3.442e-79	280.0	COG3694@1|root,COG3694@2|Bacteria,1R4BF@1224|Proteobacteria,2VJJJ@28216|Betaproteobacteria,4ABRD@80864|Comamonadaceae	28216|Betaproteobacteria	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_6
SHD2_k127_4602745_83	1268622.AVS7_00811	4.574e-74	260.0	COG4587@1|root,COG4587@2|Bacteria,1R53T@1224|Proteobacteria,2VMQH@28216|Betaproteobacteria,4ADAF@80864|Comamonadaceae	28216|Betaproteobacteria	S	transport system, permease component	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_6
SHD2_k127_4602745_47	1157708.KB907457_gene2799	1.901e-131	428.0	COG4586@1|root,COG4586@2|Bacteria,1RA7G@1224|Proteobacteria,2VHFN@28216|Betaproteobacteria,4ABQM@80864|Comamonadaceae	28216|Betaproteobacteria	S	SMART AAA ATPase	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SHD2_k127_4602745_96	1333998.M2A_0746	3.927e-59	215.0	COG5429@1|root,COG5429@2|Bacteria,1MW6R@1224|Proteobacteria,2U33F@28211|Alphaproteobacteria,4BS1D@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1223)	MA20_43790	-	-	-	-	-	-	-	-	-	-	-	DUF1223
SHD2_k127_4602745_161	1282876.BAOK01000002_gene583	2.547e-20	98.0	2E9X4@1|root,3342V@2|Bacteria,1N7Z6@1224|Proteobacteria,2UHUM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_4602745_48	402881.Plav_1571	3.829e-126	423.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2UP6H@28211|Alphaproteobacteria,1JPXD@119043|Rhodobiaceae	28211|Alphaproteobacteria	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_3
SHD2_k127_4602745_95	414684.RC1_0543	1.353e-59	212.0	COG5394@1|root,COG5394@2|Bacteria,1RHRC@1224|Proteobacteria,2TQWQ@28211|Alphaproteobacteria,2JRP3@204441|Rhodospirillales	204441|Rhodospirillales	S	Polyhydroxyalkanoate synthesis repressor	-	-	-	-	-	-	-	-	-	-	-	-	PHB_acc,PHB_acc_N
SHD2_k127_4602745_20	1429916.X566_07480	2.633e-197	621.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TQQ7@28211|Alphaproteobacteria,3JRMV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Belongs to the thiolase family	phbA	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
SHD2_k127_4602745_56	648757.Rvan_0022	2.056e-108	356.0	COG1028@1|root,COG1028@2|Bacteria,1MUEV@1224|Proteobacteria,2TRCF@28211|Alphaproteobacteria,3N82B@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	IQ	KR domain	phbB	-	1.1.1.36	ko:K00023	ko00630,ko00650,ko01120,ko01200,map00630,map00650,map01120,map01200	M00373	R01779,R01977	RC00103,RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	adh_short,adh_short_C2
SHD2_k127_4602745_108	316055.RPE_0311	2.235e-48	180.0	COG4133@1|root,COG4133@2|Bacteria,1MZPC@1224|Proteobacteria,2TVBT@28211|Alphaproteobacteria,3JR9H@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system	ccmA	-	3.6.3.41	ko:K02193	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.107	-	-	ABC_tran
SHD2_k127_4602745_94	1367847.JCM7686_0957	8.11e-60	216.0	COG2386@1|root,COG2386@2|Bacteria,1NJB0@1224|Proteobacteria,2TUSG@28211|Alphaproteobacteria,2PV9Y@265|Paracoccus	28211|Alphaproteobacteria	O	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes	ccmB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016021,GO:0031224,GO:0032991,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351	-	ko:K02194	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	CcmB
SHD2_k127_4602745_66	1197906.CAJQ02000029_gene3908	5.133e-91	304.0	COG0755@1|root,COG0755@2|Bacteria,1MU61@1224|Proteobacteria,2TSW8@28211|Alphaproteobacteria,3JRN5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes	ccmC	GO:0001539,GO:0002048,GO:0002049,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005575,GO:0005623,GO:0005886,GO:0006518,GO:0006629,GO:0006643,GO:0006664,GO:0006807,GO:0006810,GO:0006928,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009237,GO:0009247,GO:0009636,GO:0009987,GO:0015886,GO:0016020,GO:0016209,GO:0016491,GO:0016684,GO:0019184,GO:0019290,GO:0019748,GO:0034641,GO:0040011,GO:0042221,GO:0043043,GO:0043107,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044464,GO:0044550,GO:0046467,GO:0048870,GO:0050896,GO:0051179,GO:0051181,GO:0051186,GO:0051188,GO:0051234,GO:0051674,GO:0051716,GO:0055114,GO:0070887,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0071973,GO:0071975,GO:0071977,GO:0071978,GO:0097237,GO:0097588,GO:0098754,GO:0098869,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1901678,GO:1903509,GO:1990748	-	ko:K02195	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	Cytochrom_C_asm
SHD2_k127_4602745_109	1535287.JP74_22660	8.858e-46	171.0	COG0526@1|root,COG0526@2|Bacteria,1RI3N@1224|Proteobacteria,2TSEW@28211|Alphaproteobacteria,3N6ZX@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	CO	Periplasmic protein thiol disulfide oxidoreductase	ccmG	GO:0005575,GO:0005623,GO:0042597,GO:0044464	-	ko:K02199	-	-	-	-	ko00000,ko03110	-	-	-	AhpC-TSA,Redoxin
SHD2_k127_4602745_142	402881.Plav_1409	2.942e-30	126.0	COG1846@1|root,COG1846@2|Bacteria,1PC14@1224|Proteobacteria,2VAWB@28211|Alphaproteobacteria,1JQI3@119043|Rhodobiaceae	28211|Alphaproteobacteria	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_4602745_84	570967.JMLV01000002_gene1972	6.711e-71	249.0	COG1051@1|root,COG1051@2|Bacteria,1REBW@1224|Proteobacteria,2U72I@28211|Alphaproteobacteria,2JSGG@204441|Rhodospirillales	204441|Rhodospirillales	F	Nudix N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX,Nudix_N_2
SHD2_k127_4602745_107	1123366.TH3_06550	1.506e-48	181.0	COG2917@1|root,COG2917@2|Bacteria,1NWIZ@1224|Proteobacteria,2U74X@28211|Alphaproteobacteria,2JS79@204441|Rhodospirillales	204441|Rhodospirillales	D	probably involved in intracellular septation	ispZ	-	-	ko:K06190	-	-	-	-	ko00000	-	-	-	IspA
SHD2_k127_4602745_51	1333998.M2A_0760	1.025e-120	396.0	COG0552@1|root,COG0552@2|Bacteria,1MUDU@1224|Proteobacteria,2TS0M@28211|Alphaproteobacteria,4BPVU@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
SHD2_k127_4602745_33	1122929.KB908218_gene1657	8.183e-161	527.0	COG0621@1|root,COG0621@2|Bacteria,1MUCS@1224|Proteobacteria,2TRYD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	MiaB-like tRNA modifying enzyme	mtaB	GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016782,GO:0034470,GO:0034641,GO:0034660,GO:0035596,GO:0035598,GO:0035600,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0050497,GO:0071704,GO:0090304,GO:1901360	2.8.4.5	ko:K18707	-	-	R10649	RC00003,RC03221	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,UPF0004
SHD2_k127_4602745_74	856793.MICA_1511	1.472e-87	297.0	COG0253@1|root,COG0253@2|Bacteria,1MWDH@1224|Proteobacteria,2TUF2@28211|Alphaproteobacteria,4BQ2R@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF	-	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
SHD2_k127_4602745_23	1121124.JNIX01000014_gene1157	7.441e-194	627.0	COG1505@1|root,COG1505@2|Bacteria,1NZ7N@1224|Proteobacteria,2TTAX@28211|Alphaproteobacteria,2KFFQ@204458|Caulobacterales	204458|Caulobacterales	E	peptidase S9A prolyl oligopeptidase domain protein beta-propeller	-	-	3.4.21.26	ko:K01322	ko04614,map04614	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
SHD2_k127_4602745_29	876269.ARWA01000001_gene268	1.787e-175	561.0	COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,2TQSW@28211|Alphaproteobacteria,3NA1Z@45404|Beijerinckiaceae	28211|Alphaproteobacteria	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
SHD2_k127_4602745_116	1101190.ARWB01000001_gene3601	2.988e-42	158.0	COG0228@1|root,COG0228@2|Bacteria,1MZCT@1224|Proteobacteria,2U94X@28211|Alphaproteobacteria,36YH2@31993|Methylocystaceae	28211|Alphaproteobacteria	J	Ribosomal protein S16	rpsP	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
SHD2_k127_4602745_125	114615.BRADO0377	4.082e-39	151.0	COG0806@1|root,COG0806@2|Bacteria,1MWQR@1224|Proteobacteria,2U9UT@28211|Alphaproteobacteria,3JT77@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	J	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes	rimM	-	-	ko:K02860	-	-	-	-	ko00000,ko03009	-	-	-	PRC,RimM
SHD2_k127_4602745_124	479433.Caci_5542	7.819e-40	156.0	COG0454@1|root,COG0456@2|Bacteria,2IFM6@201174|Actinobacteria	201174|Actinobacteria	K	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Condensation
SHD2_k127_4602745_65	1429916.X566_08375	1.025e-93	313.0	COG0336@1|root,COG0336@2|Bacteria,1MUN1@1224|Proteobacteria,2TSIZ@28211|Alphaproteobacteria,3JUNP@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	J	Belongs to the RNA methyltransferase TrmD family	trmD	GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	tRNA_m1G_MT
SHD2_k127_4602745_110	78245.Xaut_2510	4.94e-45	166.0	COG0335@1|root,COG0335@2|Bacteria,1RH3A@1224|Proteobacteria,2U9DF@28211|Alphaproteobacteria,3EZGW@335928|Xanthobacteraceae	28211|Alphaproteobacteria	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site	rplS	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
SHD2_k127_4602745_17	414684.RC1_0024	2.158e-200	641.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2TQMR@28211|Alphaproteobacteria,2JQR8@204441|Rhodospirillales	204441|Rhodospirillales	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
SHD2_k127_4602745_75	566466.NOR53_3532	2.978e-83	286.0	COG3386@1|root,COG3386@2|Bacteria,1QN8Y@1224|Proteobacteria,1S5PU@1236|Gammaproteobacteria,1J7F2@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	G	SMP-30/Gluconolaconase/LRE-like region	-	-	3.1.1.17	ko:K01053	ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02933,R03751	RC00537,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	SGL
SHD2_k127_4602745_139	1267005.KB911257_gene1099	8.731e-33	130.0	COG0776@1|root,COG0776@2|Bacteria,1MZ5B@1224|Proteobacteria,2UC5G@28211|Alphaproteobacteria,3N91P@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Belongs to the bacterial histone-like protein family	hupA	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
SHD2_k127_4602745_6	1217720.ALOX01000027_gene3639	3.14e-314	979.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2TR80@28211|Alphaproteobacteria,2JPCQ@204441|Rhodospirillales	204441|Rhodospirillales	P	COG2217 Cation transport ATPase	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase,YHS
SHD2_k127_4602745_153	1280954.HPO_18500	8.251e-26	123.0	COG1937@1|root,COG1937@2|Bacteria,1N9P2@1224|Proteobacteria,2UF3F@28211|Alphaproteobacteria,43YIK@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	Metal-sensitive transcriptional repressor	-	-	-	ko:K21600	-	-	-	-	ko00000,ko03000	-	-	-	Trns_repr_metal
SHD2_k127_4602745_44	1229204.AMYY01000001_gene2782	4.996e-141	460.0	COG3667@1|root,COG3667@2|Bacteria,1R6TA@1224|Proteobacteria,2U52R@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	copper resistance	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_4602745_87	633149.Bresu_1689	9.46e-69	248.0	COG1835@1|root,COG1835@2|Bacteria,1PB64@1224|Proteobacteria,2VFEH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
SHD2_k127_4602745_32	1333998.M2A_0796	2.755e-161	513.0	COG0039@1|root,COG0039@2|Bacteria,1MV57@1224|Proteobacteria,2TSV6@28211|Alphaproteobacteria,4BPEW@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	GO:0003674,GO:0003824,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0016999,GO:0017144,GO:0019752,GO:0030060,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
SHD2_k127_4602745_168	945713.IALB_0952	7.942e-18	88.0	COG4704@1|root,COG4704@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2141
SHD2_k127_4602745_106	395961.Cyan7425_3624	3.807e-49	184.0	COG1670@1|root,COG1670@2|Bacteria,1GJFD@1117|Cyanobacteria,3KIY4@43988|Cyanothece	1117|Cyanobacteria	H	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
SHD2_k127_4602745_45	402881.Plav_0652	7.149e-136	445.0	COG0477@1|root,COG0477@2|Bacteria,1MXZ3@1224|Proteobacteria,2TWH9@28211|Alphaproteobacteria,1JPSN@119043|Rhodobiaceae	28211|Alphaproteobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
SHD2_k127_4602745_148	1158292.JPOE01000002_gene3420	2.71e-27	117.0	COG1881@1|root,COG1881@2|Bacteria,1N0Y4@1224|Proteobacteria,2VQJB@28216|Betaproteobacteria,1KNZJ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Phosphatidylethanolamine-binding protein	-	-	-	ko:K06910	-	-	-	-	ko00000	-	-	-	PBP
SHD2_k127_4602745_97	502025.Hoch_6098	1.003e-57	207.0	COG0457@1|root,COG0457@2|Bacteria,1QWT6@1224|Proteobacteria	1224|Proteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_4602745_143	319225.Plut_1891	3.074e-30	132.0	COG0671@1|root,COG0671@2|Bacteria,1FFMA@1090|Chlorobi	1090|Chlorobi	I	PAP2 superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PAP2
SHD2_k127_4602745_38	339670.Bamb_1418	1.826e-154	497.0	COG0477@1|root,COG2814@2|Bacteria,1MWKH@1224|Proteobacteria,2VH75@28216|Betaproteobacteria,1K1AQ@119060|Burkholderiaceae	28216|Betaproteobacteria	EGP	Major facilitator superfamily MFS_1	-	-	-	ko:K08178	-	-	-	-	ko00000,ko02000	2.A.1.12	-	-	MFS_1,Sugar_tr
SHD2_k127_4602745_180	1282876.BAOK01000001_gene1053	1.026e-10	73.0	COG2885@1|root,COG2885@2|Bacteria,1NA0J@1224|Proteobacteria,2UFTJ@28211|Alphaproteobacteria,4BSV8@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	M	COG2885 outer membrane protein and related peptidoglycan-associated (lipo)proteins	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
SHD2_k127_4602745_58	1038858.AXBA01000013_gene2463	4.116e-107	353.0	COG0483@1|root,COG0483@2|Bacteria,1MUQT@1224|Proteobacteria,2TR06@28211|Alphaproteobacteria,3EY2Q@335928|Xanthobacteraceae	28211|Alphaproteobacteria	G	Inositol monophosphatase family	suhB	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
SHD2_k127_4602745_81	935840.JAEQ01000005_gene1105	1.249e-76	262.0	COG0231@1|root,COG0231@2|Bacteria,1MW2J@1224|Proteobacteria,2TUWE@28211|Alphaproteobacteria,43IN7@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	efp	-	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
SHD2_k127_4602745_70	1123355.JHYO01000013_gene1137	4.427e-88	294.0	COG0352@1|root,COG0352@2|Bacteria,1MV42@1224|Proteobacteria,2TSSA@28211|Alphaproteobacteria,36YIR@31993|Methylocystaceae	28211|Alphaproteobacteria	H	Thiamine monophosphate synthase	thiE	-	2.5.1.3	ko:K00788	ko00730,ko01100,map00730,map01100	M00127	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	TMP-TENI
SHD2_k127_4602745_42	78245.Xaut_3077	1.234e-148	477.0	COG3588@1|root,COG3588@2|Bacteria,1MVFK@1224|Proteobacteria,2TSIV@28211|Alphaproteobacteria,3EYI5@335928|Xanthobacteraceae	28211|Alphaproteobacteria	G	Fructose-bisphosphate aldolase class-I	fbaB	-	4.1.2.13	ko:K01623	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000,ko03036,ko04131,ko04147	-	-	-	Glycolytic
SHD2_k127_4602745_28	702113.PP1Y_AT22937	2.122e-180	572.0	COG0126@1|root,COG0126@2|Bacteria,1MUNU@1224|Proteobacteria,2TSKQ@28211|Alphaproteobacteria,2K0JN@204457|Sphingomonadales	204457|Sphingomonadales	F	Belongs to the phosphoglycerate kinase family	-	-	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
SHD2_k127_4602745_31	1211115.ALIQ01000217_gene2433	1.483e-173	548.0	COG0057@1|root,COG0057@2|Bacteria,1MU93@1224|Proteobacteria,2TR6E@28211|Alphaproteobacteria,3N9XI@45404|Beijerinckiaceae	28211|Alphaproteobacteria	G	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain	gapA	GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
SHD2_k127_4602745_7	935261.JAGL01000029_gene359	5.638e-266	833.0	COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,2TQUX@28211|Alphaproteobacteria,43J2N@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	tktA	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
SHD2_k127_4602745_160	402881.Plav_2110	7.92e-21	96.0	COG3027@1|root,COG3027@2|Bacteria,1N8NY@1224|Proteobacteria,2UCRX@28211|Alphaproteobacteria,1JPGU@119043|Rhodobiaceae	28211|Alphaproteobacteria	D	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division	MA20_17980	-	-	ko:K09888	-	-	-	-	ko00000,ko03036	-	-	-	ZapA
SHD2_k127_4602745_117	1217720.ALOX01000006_gene1662	3.917e-42	160.0	COG0212@1|root,COG0212@2|Bacteria,1MZG0@1224|Proteobacteria,2UBY4@28211|Alphaproteobacteria,2JTJ1@204441|Rhodospirillales	204441|Rhodospirillales	H	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family	-	-	6.3.3.2	ko:K01934	ko00670,ko01100,map00670,map01100	-	R02301	RC00183	ko00000,ko00001,ko01000	-	-	-	5-FTHF_cyc-lig
SHD2_k127_4691863_0	83219.PM02_07815	4.28e-223	702.0	COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,2TRMY@28211|Alphaproteobacteria,3ZW2J@60136|Sulfitobacter	28211|Alphaproteobacteria	F	Involved in de novo purine biosynthesis	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
SHD2_k127_4691863_13	1123354.AUDR01000019_gene150	3.375e-05	50.0	COG3071@1|root,COG3071@2|Bacteria,1Q94M@1224|Proteobacteria,2WCDN@28216|Betaproteobacteria,1KTGX@119069|Hydrogenophilales	119069|Hydrogenophilales	H	Protein of unknown function (DUF2905)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2905
SHD2_k127_4691863_1	395965.Msil_2131	2.652e-194	614.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2TQND@28211|Alphaproteobacteria,3NA7I@45404|Beijerinckiaceae	28211|Alphaproteobacteria	H	Aminotransferase class-III	bioA	-	2.6.1.62	ko:K00833	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03231	RC00006,RC00887	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
SHD2_k127_4691863_3	402881.Plav_0036	5.939e-151	483.0	COG0502@1|root,COG0502@2|Bacteria,1MVFF@1224|Proteobacteria,2TSD6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism	bioB	-	2.8.1.6	ko:K01012	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000	-	-	-	BATS,Radical_SAM
SHD2_k127_4691863_5	395964.KE386496_gene1448	3.419e-62	222.0	COG0132@1|root,COG0132@2|Bacteria,1RDRK@1224|Proteobacteria,2U5AJ@28211|Alphaproteobacteria,3NB1C@45404|Beijerinckiaceae	28211|Alphaproteobacteria	H	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring	bioD	GO:0003674,GO:0003824,GO:0004141,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.1.197,6.3.3.3	ko:K01935,ko:K02169	ko00780,ko01100,map00780,map01100	M00123,M00572,M00573,M00577	R03182,R09543	RC00003,RC00460,RC00868	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_26
SHD2_k127_4691863_4	1429916.X566_19340	1.351e-93	312.0	COG0625@1|root,COG0625@2|Bacteria,1Q05U@1224|Proteobacteria,2U5IH@28211|Alphaproteobacteria,3K65Q@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_2,GST_N,GST_N_3
SHD2_k127_4691863_11	1536769.P40081_16165	3.205e-09	60.0	2EGSG@1|root,33AIJ@2|Bacteria,1VMPG@1239|Firmicutes,4HRBP@91061|Bacilli,277T5@186822|Paenibacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_4691863_6	1111479.AXAR01000006_gene748	1.105e-53	200.0	COG1072@1|root,COG1072@2|Bacteria,1TPHJ@1239|Firmicutes,4HA4K@91061|Bacilli	91061|Bacilli	F	Pantothenic acid kinase	coaA	GO:0003674,GO:0003824,GO:0004594,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.1.33	ko:K00867	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PRK
SHD2_k127_4691863_2	1121127.JAFA01000009_gene7004	3.393e-170	548.0	COG0477@1|root,COG0477@2|Bacteria,1MXBV@1224|Proteobacteria,2VMP5@28216|Betaproteobacteria,1K0MF@119060|Burkholderiaceae	28216|Betaproteobacteria	EGP	transporter	-	-	-	ko:K08369	-	-	-	-	ko00000,ko02000	2.A.1	-	-	Sugar_tr
SHD2_k127_4691863_10	1441930.Z042_12635	8.691e-17	83.0	COG1266@1|root,COG1266@2|Bacteria,1PZ77@1224|Proteobacteria,1RV9N@1236|Gammaproteobacteria,4059V@613|Serratia	1236|Gammaproteobacteria	S	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
SHD2_k127_4691863_9	593750.Metfor_1855	2.075e-22	102.0	COG1266@1|root,arCOG02768@2157|Archaea,2XZ3X@28890|Euryarchaeota,2NAUF@224756|Methanomicrobia	224756|Methanomicrobia	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
SHD2_k127_4691863_7	1150864.MILUP08_43252	1.165e-47	173.0	COG3877@1|root,COG3877@2|Bacteria,2IJTS@201174|Actinobacteria,4DDM4@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF2089)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2089
SHD2_k127_4691863_8	749414.SBI_06417	2.577e-39	150.0	2DRM1@1|root,33C8J@2|Bacteria,2IJ2W@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_48285_10	450851.PHZ_c0958	5.544e-150	493.0	COG2272@1|root,COG2272@2|Bacteria,1MVQZ@1224|Proteobacteria,2TTHT@28211|Alphaproteobacteria,2KHUT@204458|Caulobacterales	204458|Caulobacterales	I	Belongs to the type-B carboxylesterase lipase family	-	-	-	ko:K03929	-	-	-	-	ko00000,ko01000	-	CE10	-	COesterase
SHD2_k127_48285_11	1206737.BAGF01000087_gene5631	7.446e-144	470.0	COG3669@1|root,COG3669@2|Bacteria,2HUEI@201174|Actinobacteria,4FZD7@85025|Nocardiaceae	201174|Actinobacteria	G	Alpha-L-fucosidase	-	-	3.2.1.51	ko:K01206	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04147	-	GH29	-	Alpha_L_fucos
SHD2_k127_48285_1	1429916.X566_09735	1.628e-252	783.0	COG2141@1|root,COG2141@2|Bacteria,1NX0H@1224|Proteobacteria,2U42F@28211|Alphaproteobacteria,3K6H5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
SHD2_k127_48285_13	402881.Plav_0572	3.673e-136	438.0	COG0596@1|root,COG0596@2|Bacteria,1PFTV@1224|Proteobacteria,2V8R3@28211|Alphaproteobacteria,1JQG3@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Thioesterase domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_48285_2	1205680.CAKO01000010_gene3916	1.045e-251	788.0	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,2TSZZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG3653 N-acyl-D-aspartate D-glutamate deacylase	MA20_22865	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
SHD2_k127_48285_17	402881.Plav_0577	7.518e-130	424.0	COG2175@1|root,COG2175@2|Bacteria,1Q0C7@1224|Proteobacteria,2TRGF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Taurine catabolism dioxygenase TauD, TfdA	-	-	-	-	-	-	-	-	-	-	-	-	TauD
SHD2_k127_48285_3	1282876.BAOK01000001_gene3633	4.564e-214	676.0	COG0318@1|root,COG0318@2|Bacteria,1MVJ1@1224|Proteobacteria,2TUQ9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	IQ	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II	-	-	6.2.1.42	ko:K00666,ko:K18688	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
SHD2_k127_48285_21	1121123.AUAO01000001_gene783	1.049e-80	278.0	COG2207@1|root,COG2207@2|Bacteria,1P23G@1224|Proteobacteria,2TTZN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,HTH_18
SHD2_k127_48285_22	1121015.N789_10390	1.842e-76	267.0	COG1266@1|root,COG1266@2|Bacteria,1MY1N@1224|Proteobacteria	1224|Proteobacteria	S	infection protein	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
SHD2_k127_48285_32	391937.NA2_02699	1.63e-24	117.0	COG1556@1|root,COG1556@2|Bacteria,1R4TE@1224|Proteobacteria,2U5II@28211|Alphaproteobacteria,43HRQ@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	LUD domain	-	-	-	ko:K00782	-	-	-	-	ko00000	-	-	-	LUD_dom
SHD2_k127_48285_7	1121033.AUCF01000003_gene3463	6.306e-169	550.0	COG1139@1|root,COG1139@2|Bacteria,1MV6J@1224|Proteobacteria,2TT1X@28211|Alphaproteobacteria,2JQBE@204441|Rhodospirillales	204441|Rhodospirillales	C	LUD domain	-	-	-	ko:K18929	-	-	-	-	ko00000	-	-	-	DUF3390,Fer4_17,Fer4_8,LUD_dom
SHD2_k127_48285_19	1207063.P24_02961	7.708e-101	335.0	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,2TR9H@28211|Alphaproteobacteria,2JQMV@204441|Rhodospirillales	204441|Rhodospirillales	C	(Fe-S) oxidoreductase	-	-	-	ko:K18928	-	-	-	-	ko00000	-	-	-	CCG
SHD2_k127_48285_20	331869.BAL199_21989	5.354e-90	305.0	COG0204@1|root,COG0204@2|Bacteria,1QU3F@1224|Proteobacteria,2U1AI@28211|Alphaproteobacteria,4BQ47@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	I	Phosphate acyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase
SHD2_k127_48285_15	1282876.BAOK01000001_gene1456	4.941e-133	432.0	COG2267@1|root,COG2267@2|Bacteria,1QU7K@1224|Proteobacteria,2TW27@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Alpha beta hydrolase	-	-	2.7.10.2,3.3.2.9	ko:K01253,ko:K08253	ko00980,ko04976,ko05204,map00980,map04976,map05204	-	R07013,R07014,R07027,R07071,R07072,R07082,R09410,R09417,R09443	RC01447,RC01728,RC01764,RC02528	ko00000,ko00001,ko01000,ko01002	-	-	-	Abhydrolase_1
SHD2_k127_48285_9	402881.Plav_2498	3.59e-163	530.0	COG0644@1|root,COG0644@2|Bacteria,1QXH6@1224|Proteobacteria,2U52M@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	And related	-	-	-	-	-	-	-	-	-	-	-	-	DAO,FAD_binding_2
SHD2_k127_48285_30	215803.DB30_3559	1.411e-28	119.0	COG2363@1|root,COG2363@2|Bacteria,1MZX3@1224|Proteobacteria,42UHB@68525|delta/epsilon subdivisions,2WQHM@28221|Deltaproteobacteria,2YVPY@29|Myxococcales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF423)	-	-	-	-	-	-	-	-	-	-	-	-	DUF423
SHD2_k127_48285_8	1282876.BAOK01000001_gene1589	2.821e-168	551.0	COG1473@1|root,COG1473@2|Bacteria,1MX6N@1224|Proteobacteria,2UQ2S@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
SHD2_k127_48285_26	402881.Plav_2615	2.224e-60	218.0	COG1073@1|root,COG1073@2|Bacteria,1QY19@1224|Proteobacteria,2TXFD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	PFAM alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
SHD2_k127_48285_4	1207063.P24_05054	9.998e-194	616.0	COG1960@1|root,COG1960@2|Bacteria,1MUK0@1224|Proteobacteria,2TSAC@28211|Alphaproteobacteria,2JPB4@204441|Rhodospirillales	204441|Rhodospirillales	I	Acyl-CoA dehydrogenase, middle domain	-	-	1.3.8.6	ko:K00252	ko00071,ko00310,ko00362,ko00380,ko01100,ko01120,ko01130,map00071,map00310,map00362,map00380,map01100,map01120,map01130	M00032	R02487,R02488,R10074	RC00052,RC00156	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
SHD2_k127_48285_12	228405.HNE_2323	2.518e-136	445.0	COG1804@1|root,COG1804@2|Bacteria,1PRUN@1224|Proteobacteria,2U183@28211|Alphaproteobacteria,43Z4C@69657|Hyphomonadaceae	28211|Alphaproteobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
SHD2_k127_48285_6	450851.PHZ_c2098	5.132e-169	542.0	COG2311@1|root,COG2311@2|Bacteria,1MWHW@1224|Proteobacteria,2U310@28211|Alphaproteobacteria,2KGA8@204458|Caulobacterales	204458|Caulobacterales	S	Protein of unknown function (DUF418)	-	-	-	ko:K07148	-	-	-	-	ko00000	-	-	-	DUF418
SHD2_k127_48285_16	402881.Plav_0450	9.448e-131	423.0	COG1028@1|root,COG1028@2|Bacteria,1PFUB@1224|Proteobacteria,2U149@28211|Alphaproteobacteria,1JQM5@119043|Rhodobiaceae	28211|Alphaproteobacteria	IQ	PFAM short-chain dehydrogenase reductase SDR	MA20_16350	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
SHD2_k127_48285_0	402881.Plav_0453	0.0	1088.0	COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,2TR7V@28211|Alphaproteobacteria,1JNBC@119043|Rhodobiaceae	28211|Alphaproteobacteria	L	DEAD/H associated	lhr	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
SHD2_k127_48285_23	1122132.AQYH01000004_gene1704	4.186e-73	254.0	COG1407@1|root,COG1407@2|Bacteria,1RC5G@1224|Proteobacteria,2TU2T@28211|Alphaproteobacteria,4B9P1@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Calcineurin-like phosphoesterase	MA20_22045	-	-	ko:K06953	-	-	-	-	ko00000	-	-	-	Metallophos
SHD2_k127_48285_27	1333998.M2A_2087	1.924e-55	210.0	2AFUA@1|root,315WQ@2|Bacteria,1NHGB@1224|Proteobacteria,2TQWW@28211|Alphaproteobacteria,4BQMD@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Putative transmembrane protein (Alph_Pro_TM)	MA20_19830	-	-	-	-	-	-	-	-	-	-	-	Alph_Pro_TM
SHD2_k127_48285_18	439375.Oant_4039	2.414e-115	381.0	COG0730@1|root,COG0730@2|Bacteria,1MWX2@1224|Proteobacteria,2TRIC@28211|Alphaproteobacteria,1J1ZU@118882|Brucellaceae	28211|Alphaproteobacteria	S	Sulfite exporter TauE/SafE	MA20_19835	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
SHD2_k127_48285_24	402881.Plav_0458	1.601e-69	265.0	COG0790@1|root,COG1196@1|root,COG3409@1|root,COG0790@2|Bacteria,COG1196@2|Bacteria,COG3409@2|Bacteria,1MWPA@1224|Proteobacteria,2TR2B@28211|Alphaproteobacteria,1JNWK@119043|Rhodobiaceae	28211|Alphaproteobacteria	DM	Sel1-like repeats.	-	-	-	ko:K07126,ko:K13582	ko04112,map04112	-	-	-	ko00000,ko00001	-	-	-	PG_binding_1,Sel1
SHD2_k127_48285_35	1397666.RS24_00460	1.376e-14	77.0	COG4323@1|root,COG4323@2|Bacteria,1N16T@1224|Proteobacteria,2U9EX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF962
SHD2_k127_48285_37	215803.DB30_6523	4.342e-07	58.0	COG4323@1|root,COG4323@2|Bacteria,1N16T@1224|Proteobacteria,4315K@68525|delta/epsilon subdivisions,2WWYY@28221|Deltaproteobacteria,2YVYB@29|Myxococcales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF962)	-	-	-	-	-	-	-	-	-	-	-	-	DUF962
SHD2_k127_48285_36	1230457.C476_13892	1.048e-10	70.0	COG2340@1|root,arCOG03962@2157|Archaea,2XT4K@28890|Euryarchaeota,23W0I@183963|Halobacteria	183963|Halobacteria	S	Cysteine-rich secretory protein family	-	-	-	-	-	-	-	-	-	-	-	-	CAP
SHD2_k127_48285_5	1333998.M2A_2121	3.285e-185	587.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TQQ7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Belongs to the thiolase family	MA20_05130	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
SHD2_k127_48285_28	1429916.X566_12505	2.475e-34	138.0	COG2917@1|root,COG2917@2|Bacteria,1P9FF@1224|Proteobacteria,2TR7Y@28211|Alphaproteobacteria,3JRH8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	D	probably involved in intracellular septation	-	-	-	-	-	-	-	-	-	-	-	-	IspA
SHD2_k127_48285_34	1500894.JQNN01000001_gene4065	2.928e-17	90.0	COG2917@1|root,COG2917@2|Bacteria,1QKX9@1224|Proteobacteria,2W2G4@28216|Betaproteobacteria	28216|Betaproteobacteria	D	probably involved in intracellular septation	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_48285_31	29581.BW37_05364	2.703e-27	126.0	COG0457@1|root,COG0457@2|Bacteria,1Q7UR@1224|Proteobacteria,2VKBS@28216|Betaproteobacteria,4768W@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6
SHD2_k127_48285_33	1122614.JHZF01000013_gene3190	8.003e-22	100.0	COG2050@1|root,COG2050@2|Bacteria,1NA0B@1224|Proteobacteria,2UI6H@28211|Alphaproteobacteria,2PEP4@252301|Oceanicola	28211|Alphaproteobacteria	Q	Thioesterase superfamily	MA20_21000	-	-	-	-	-	-	-	-	-	-	-	4HBT
SHD2_k127_48285_29	402881.Plav_0491	1.901e-33	135.0	COG2050@1|root,COG2050@2|Bacteria,1NA0B@1224|Proteobacteria,2UI6H@28211|Alphaproteobacteria,1JQFI@119043|Rhodobiaceae	28211|Alphaproteobacteria	Q	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
SHD2_k127_48285_25	1122951.ATUE01000005_gene1677	4.263e-61	220.0	COG1028@1|root,COG1028@2|Bacteria,1ND2U@1224|Proteobacteria,1RZZH@1236|Gammaproteobacteria,3NMAA@468|Moraxellaceae	1236|Gammaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
SHD2_k127_48285_14	1380394.JADL01000005_gene5464	1.124e-134	450.0	COG0664@1|root,COG1752@1|root,COG0664@2|Bacteria,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,2TVQR@28211|Alphaproteobacteria,2JUNY@204441|Rhodospirillales	204441|Rhodospirillales	K	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin,cNMP_binding
SHD2_k127_48285_38	1095772.CAHH01000011_gene739	5.32e-05	49.0	COG1247@1|root,COG1247@2|Bacteria	2|Bacteria	M	phosphinothricin N-acetyltransferase activity	XK27_05885	-	2.3.1.82	ko:K18816	-	-	-	-	br01600,ko00000,ko01000,ko01504	-	-	-	Acetyltransf_1
SHD2_k127_4949904_14	929556.Solca_0508	1.311e-37	152.0	COG5164@1|root,COG5164@2|Bacteria,4PNUX@976|Bacteroidetes,1J0TG@117747|Sphingobacteriia	976|Bacteroidetes	K	regulation of DNA-templated transcription, elongation	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_4949904_10	402881.Plav_0125	7.784e-49	175.0	2AFEN@1|root,33YY6@2|Bacteria,1NXEW@1224|Proteobacteria,2UT2Q@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_4949904_8	309799.DICTH_1189	1.141e-60	224.0	COG0265@1|root,COG0265@2|Bacteria	2|Bacteria	O	serine-type endopeptidase activity	pepD	-	-	ko:K08372	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Trypsin,Trypsin_2
SHD2_k127_4949904_0	1502850.FG91_00575	2.641e-185	616.0	COG1629@1|root,COG4773@1|root,COG1629@2|Bacteria,COG4773@2|Bacteria,1R479@1224|Proteobacteria,2TV3V@28211|Alphaproteobacteria,2K147@204457|Sphingomonadales	28211|Alphaproteobacteria	P	COG1629 Outer membrane receptor proteins, mostly Fe transport	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
SHD2_k127_4949904_12	452662.SJA_C1-26920	8.5e-45	175.0	COG0583@1|root,COG0583@2|Bacteria,1NCEE@1224|Proteobacteria,2UHME@28211|Alphaproteobacteria,2KB5Q@204457|Sphingomonadales	204457|Sphingomonadales	K	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
SHD2_k127_4949904_4	1248916.ANFY01000004_gene1854	6.793e-101	331.0	COG0625@1|root,COG0625@2|Bacteria,1RD4X@1224|Proteobacteria,2U63J@28211|Alphaproteobacteria,2KD19@204457|Sphingomonadales	204457|Sphingomonadales	O	Glutathione S-transferase, C-terminal domain	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_N
SHD2_k127_4949904_3	1280954.HPO_18023	3.863e-128	418.0	COG2130@1|root,COG2130@2|Bacteria,1MUC2@1224|Proteobacteria,2TQYM@28211|Alphaproteobacteria,43XEM@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	NADP-dependent	MA20_27525	-	1.1.1.1	ko:K00001,ko:K07119	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N_2,ADH_zinc_N
SHD2_k127_4949904_2	1122135.KB893134_gene3306	2.608e-143	487.0	COG5373@1|root,COG5373@2|Bacteria,1N08V@1224|Proteobacteria,2TWNB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF2339
SHD2_k127_4949904_1	1380394.JADL01000005_gene5542	2.637e-178	570.0	COG1680@1|root,COG1680@2|Bacteria,1MVPR@1224|Proteobacteria,2TQRF@28211|Alphaproteobacteria,2JSZU@204441|Rhodospirillales	204441|Rhodospirillales	V	Beta-lactamase	-	-	3.4.16.4	ko:K01286	-	-	-	-	ko00000,ko01000	-	-	-	Beta-lactamase
SHD2_k127_4949904_11	345341.KUTG_09857	9.093e-47	180.0	2CCFM@1|root,33T1W@2|Bacteria,2IA4M@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PhyH
SHD2_k127_4949904_6	1242864.D187_004787	1.496e-82	285.0	COG2175@1|root,COG2175@2|Bacteria,1Q0C7@1224|Proteobacteria,433XH@68525|delta/epsilon subdivisions,2X2FU@28221|Deltaproteobacteria,2YXR6@29|Myxococcales	28221|Deltaproteobacteria	Q	Taurine catabolism dioxygenase TauD, TfdA family	-	-	-	-	-	-	-	-	-	-	-	-	TauD
SHD2_k127_4949904_9	1082933.MEA186_07689	1.575e-56	207.0	COG2518@1|root,COG2518@2|Bacteria,1NARK@1224|Proteobacteria,2UG84@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_4949904_13	1331060.RLDS_20505	5.08e-41	163.0	COG0741@1|root,COG0741@2|Bacteria,1RHHP@1224|Proteobacteria,2UABC@28211|Alphaproteobacteria,2K4I0@204457|Sphingomonadales	204457|Sphingomonadales	M	Transglycosylase SLT domain	-	-	-	-	-	-	-	-	-	-	-	-	SLT
SHD2_k127_4949904_17	1449976.KALB_1133	3.837e-06	53.0	COG3103@1|root,COG3103@2|Bacteria,2GU0X@201174|Actinobacteria,4EEWJ@85010|Pseudonocardiales	201174|Actinobacteria	T	Protein of unknown function (DUF3761)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3761
SHD2_k127_4949904_5	1205680.CAKO01000038_gene1920	3.772e-94	316.0	COG2020@1|root,COG2020@2|Bacteria,1MWU6@1224|Proteobacteria,2TU80@28211|Alphaproteobacteria,2JU60@204441|Rhodospirillales	204441|Rhodospirillales	O	methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
SHD2_k127_4949904_7	366602.Caul_1212	1.184e-61	229.0	COG1357@1|root,COG1357@2|Bacteria,1R9K8@1224|Proteobacteria,2U33V@28211|Alphaproteobacteria,2KEYM@204458|Caulobacterales	204458|Caulobacterales	S	PFAM pentapeptide repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	Pentapeptide
SHD2_k127_4949904_15	1429916.X566_03240	1.58e-37	154.0	COG2911@1|root,COG3210@1|root,COG2911@2|Bacteria,COG3210@2|Bacteria,1MXIP@1224|Proteobacteria,2TTVB@28211|Alphaproteobacteria,3JS9Y@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	U	haemagglutination activity domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3739,Glug,Haemagg_act
SHD2_k127_5008677_20	670307.HYPDE_39738	0.0001609	47.0	COG1662@1|root,COG1662@2|Bacteria,1MV8R@1224|Proteobacteria,2TURN@28211|Alphaproteobacteria,3N88S@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS1,DDE_Tnp_IS240
SHD2_k127_5008677_3	1037409.BJ6T_15220	1.293e-111	374.0	COG0702@1|root,COG0702@2|Bacteria,1QU1T@1224|Proteobacteria,2TTHK@28211|Alphaproteobacteria,3K6Q3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	GM	NAD dependent epimerase/dehydratase family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
SHD2_k127_5008677_12	1183438.GKIL_0131	4.867e-36	143.0	COG3791@1|root,COG3791@2|Bacteria	2|Bacteria	S	Glutathione-dependent formaldehyde-activating	-	-	-	-	-	-	-	-	-	-	-	-	GFA
SHD2_k127_5008677_18	1163407.UU7_06483	9.658e-08	61.0	COG5455@1|root,COG5455@2|Bacteria,1NGVG@1224|Proteobacteria,1S9K0@1236|Gammaproteobacteria,1X887@135614|Xanthomonadales	135614|Xanthomonadales	S	integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	RcnB
SHD2_k127_5008677_1	246197.MXAN_0695	2.854e-241	768.0	COG1032@1|root,COG1032@2|Bacteria,1PDZR@1224|Proteobacteria,42M73@68525|delta/epsilon subdivisions,2WK6Y@28221|Deltaproteobacteria,2Z0V3@29|Myxococcales	28221|Deltaproteobacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
SHD2_k127_5008677_19	667632.KB890198_gene1156	1.025e-05	51.0	COG2862@1|root,COG2862@2|Bacteria,1RANN@1224|Proteobacteria,2VK3P@28216|Betaproteobacteria,1K9KV@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Uncharacterized protein family, UPF0114	-	-	-	-	-	-	-	-	-	-	-	-	UPF0114
SHD2_k127_5008677_9	1297865.APJD01000003_gene6291	2.563e-45	169.0	COG5646@1|root,COG5646@2|Bacteria,1N03F@1224|Proteobacteria,2U57T@28211|Alphaproteobacteria,3JYDA@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	InterPro IPR014922	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
SHD2_k127_5008677_8	398525.KB900701_gene958	1.933e-81	280.0	COG0625@1|root,COG0625@2|Bacteria,1MX33@1224|Proteobacteria,2TV9R@28211|Alphaproteobacteria,3JRRN@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Outer mitochondrial membrane transport complex protein	MA20_18730	-	-	-	-	-	-	-	-	-	-	-	GST_C_2,GST_C_6,GST_N_4
SHD2_k127_5008677_7	190650.CC_2312	1.802e-81	280.0	COG2378@1|root,COG2378@2|Bacteria,1MXS8@1224|Proteobacteria,2TT5H@28211|Alphaproteobacteria,2KGF0@204458|Caulobacterales	204458|Caulobacterales	K	WYL domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_11,WYL
SHD2_k127_5008677_5	69395.JQLZ01000001_gene3321	1.208e-99	337.0	28NB7@1|root,2ZBEQ@2|Bacteria,1R97X@1224|Proteobacteria,2U16I@28211|Alphaproteobacteria,2KJXZ@204458|Caulobacterales	204458|Caulobacterales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_5008677_17	335659.S23_61520	5.335e-09	63.0	COG1522@1|root,COG1522@2|Bacteria,1RAV4@1224|Proteobacteria,2U67I@28211|Alphaproteobacteria,3JYB4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	sequence-specific DNA binding	MA20_05845	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR
SHD2_k127_5008677_14	402881.Plav_0574	2.618e-19	93.0	2EGDK@1|root,31BUJ@2|Bacteria,1Q7SS@1224|Proteobacteria,2UUEB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_5008677_11	1430440.MGMSRv2_3235	3.709e-37	159.0	COG2930@1|root,COG2930@2|Bacteria,1RHV6@1224|Proteobacteria,2U9N6@28211|Alphaproteobacteria,2JSQS@204441|Rhodospirillales	204441|Rhodospirillales	S	Las17-binding protein actin regulator	-	-	-	-	-	-	-	-	-	-	-	-	Ysc84
SHD2_k127_5008677_10	1382306.JNIM01000001_gene3437	4.884e-38	163.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
SHD2_k127_5008677_15	1191460.F959_02874	7.632e-17	89.0	COG3671@1|root,COG3671@2|Bacteria,1MZMW@1224|Proteobacteria,1SF8E@1236|Gammaproteobacteria,3NNM0@468|Moraxellaceae	1236|Gammaproteobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_5008677_16	641149.HMPREF9016_00058	1.452e-10	67.0	COG3671@1|root,COG3671@2|Bacteria,1MZMW@1224|Proteobacteria,2WG1I@28216|Betaproteobacteria,2KU3Q@206351|Neisseriales	206351|Neisseriales	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_5008677_6	652103.Rpdx1_3946	7.08e-91	302.0	COG0625@1|root,COG0625@2|Bacteria,1Q05U@1224|Proteobacteria,2TTDK@28211|Alphaproteobacteria,3JVWD@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Glutathione S-transferase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	GST_C,GST_C_2,GST_N,GST_N_3
SHD2_k127_5008677_2	1545915.JROG01000008_gene3489	7.648e-114	398.0	COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,2TTI2@28211|Alphaproteobacteria,2K0SD@204457|Sphingomonadales	204457|Sphingomonadales	P	COG1629 Outer membrane receptor proteins, mostly Fe transport	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
SHD2_k127_5008677_4	1333998.M2A_2639	1.942e-110	364.0	COG0491@1|root,COG0491@2|Bacteria,1MVC3@1224|Proteobacteria,2TUAZ@28211|Alphaproteobacteria,4BRW1@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Metallo-beta-lactamase superfamily	MA20_07390	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
SHD2_k127_5008677_21	1333998.M2A_2145	0.0004327	49.0	COG5388@1|root,COG5388@2|Bacteria,1NNZV@1224|Proteobacteria,2UKJJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	PAS_5
SHD2_k127_5008677_13	472759.Nhal_3593	1.61e-35	145.0	COG4446@1|root,COG4446@2|Bacteria,1N31A@1224|Proteobacteria,1RRKY@1236|Gammaproteobacteria,1X0TK@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function (DUF1499)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1499
SHD2_k127_5008677_0	1381123.AYOD01000068_gene224	6.195e-250	782.0	COG0318@1|root,COG0318@2|Bacteria,1MUMC@1224|Proteobacteria,2TR96@28211|Alphaproteobacteria,43IT5@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	alkK	-	6.2.1.44,6.2.1.48	ko:K00666,ko:K02182,ko:K20034	ko00920,map00920	-	R10820	RC00004,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
SHD2_k127_5072871_0	398525.KB900701_gene5677	3.082e-95	315.0	COG0599@1|root,COG0599@2|Bacteria,1N0Z6@1224|Proteobacteria,2VGPU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Carboxymuconolactone decarboxylase family	-	-	-	-	-	-	-	-	-	-	-	-	CMD
SHD2_k127_5072871_2	46429.BV95_01190	2.98e-24	108.0	COG0346@1|root,COG0346@2|Bacteria,1NXFQ@1224|Proteobacteria,2UTRY@28211|Alphaproteobacteria,2KAT7@204457|Sphingomonadales	204457|Sphingomonadales	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase_4
SHD2_k127_5072871_1	257310.BB1077	3.727e-41	164.0	COG2159@1|root,COG2159@2|Bacteria,1MUUR@1224|Proteobacteria,2VM1S@28216|Betaproteobacteria,3T51K@506|Alcaligenaceae	28216|Betaproteobacteria	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
SHD2_k127_5072871_3	1128398.Curi_c18980	3.646e-20	93.0	COG1028@1|root,COG1028@2|Bacteria,1TSND@1239|Firmicutes,24DU0@186801|Clostridia	186801|Clostridia	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
SHD2_k127_5111554_0	398525.KB900701_gene4046	6.161e-283	874.0	COG4372@1|root,COG4372@2|Bacteria,1MUCX@1224|Proteobacteria,2TR59@28211|Alphaproteobacteria,3JT7K@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66
SHD2_k127_5111554_3	1304878.AUGD01000027_gene1069	3.638e-63	219.0	COG3436@1|root,COG3436@2|Bacteria,1MZFT@1224|Proteobacteria,2U7MB@28211|Alphaproteobacteria,3K00J@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	IS66 Orf2 like protein	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	TnpB_IS66
SHD2_k127_5111554_2	323097.Nham_3008	6.494e-73	248.0	COG2963@1|root,COG2963@2|Bacteria,1MYEC@1224|Proteobacteria,2UCQG@28211|Alphaproteobacteria,3JZD0@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Transposase	-	-	-	ko:K07483	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
SHD2_k127_5111554_4	1380355.JNIJ01000094_gene274	6.621e-28	115.0	COG3509@1|root,COG3509@2|Bacteria,1MXUI@1224|Proteobacteria,2TUS5@28211|Alphaproteobacteria,3JRUS@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Esterase PHB depolymerase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase_phd
SHD2_k127_5111554_5	1038859.AXAU01000001_gene3255	6.933e-11	63.0	2AHTW@1|root,3186H@2|Bacteria,1N3ZB@1224|Proteobacteria,2UDXN@28211|Alphaproteobacteria,3K05S@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_5111554_6	224911.27354804	2.527e-08	58.0	2AFME@1|root,315NQ@2|Bacteria,1NE70@1224|Proteobacteria,2UHK5@28211|Alphaproteobacteria,3K1BT@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_5111554_1	1380355.JNIJ01000094_gene274	3.141e-75	254.0	COG3509@1|root,COG3509@2|Bacteria,1MXUI@1224|Proteobacteria,2TUS5@28211|Alphaproteobacteria,3JRUS@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Esterase PHB depolymerase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase_phd
SHD2_k127_5140338_10	1229204.AMYY01000005_gene1568	2.67e-09	57.0	COG2265@1|root,COG2265@2|Bacteria,1MV3A@1224|Proteobacteria,2TR40@28211|Alphaproteobacteria,4BPZU@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	J	tRNA (Uracil-5-)-methyltransferase	rumA	-	2.1.1.190,2.1.1.35	ko:K00557,ko:K03215	-	-	-	-	ko00000,ko01000,ko03009,ko03016	-	-	-	tRNA_U5-meth_tr
SHD2_k127_5140338_5	1449049.JONW01000010_gene3680	2.614e-68	240.0	COG4249@1|root,COG4249@2|Bacteria,1QU7W@1224|Proteobacteria,2U7FJ@28211|Alphaproteobacteria,2KITW@204458|Caulobacterales	204458|Caulobacterales	S	Peptidase C13 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C13
SHD2_k127_5140338_1	1336243.JAEA01000003_gene2184	3.471e-183	584.0	COG0082@1|root,COG0082@2|Bacteria,1MU98@1224|Proteobacteria,2TQY2@28211|Alphaproteobacteria,1JSKV@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
SHD2_k127_5140338_8	1123229.AUBC01000020_gene4406	7.295e-26	114.0	COG0406@1|root,COG0406@2|Bacteria,1NPC4@1224|Proteobacteria,2U9WD@28211|Alphaproteobacteria,3JRMW@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Phosphoglycerate mutase family	gpmB	-	5.4.2.12	ko:K15634	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
SHD2_k127_5140338_7	1267005.KB911259_gene3936	2.803e-39	154.0	COG0406@1|root,COG0406@2|Bacteria,1NPC4@1224|Proteobacteria,2U9WD@28211|Alphaproteobacteria,3N74J@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	G	Phosphoglycerate mutase family	gpmB	-	5.4.2.12	ko:K15634	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
SHD2_k127_5140338_4	89187.ISM_14830	1.115e-128	417.0	COG0623@1|root,COG0623@2|Bacteria,1MV05@1224|Proteobacteria,2TSU4@28211|Alphaproteobacteria,46PR4@74030|Roseovarius	28211|Alphaproteobacteria	I	Enoyl- acyl-carrier-protein reductase NADH	fabI2	-	1.3.1.10,1.3.1.9	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
SHD2_k127_5140338_3	1280949.HAD_00915	3.801e-130	430.0	COG2159@1|root,COG2159@2|Bacteria,1MVTS@1224|Proteobacteria,2VGQX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
SHD2_k127_5140338_2	450851.PHZ_c2571	1.544e-146	476.0	COG1680@1|root,COG1680@2|Bacteria,1MVPR@1224|Proteobacteria,2TRWZ@28211|Alphaproteobacteria,2KFNJ@204458|Caulobacterales	28211|Alphaproteobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
SHD2_k127_5140338_6	509190.Cseg_2321	2.134e-61	219.0	2919Q@1|root,2ZNWS@2|Bacteria,1NAF5@1224|Proteobacteria,2U3AC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	MA20_20955	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_5140338_0	402881.Plav_0210	5.339e-210	658.0	COG2141@1|root,COG2141@2|Bacteria,1MX64@1224|Proteobacteria,2TV8M@28211|Alphaproteobacteria,1JPI5@119043|Rhodobiaceae	28211|Alphaproteobacteria	C	PFAM luciferase family protein	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
SHD2_k127_527676_48	402881.Plav_0233	2.372e-14	74.0	COG4964@1|root,COG4964@2|Bacteria,1MV8G@1224|Proteobacteria,2TRNN@28211|Alphaproteobacteria,1JNJW@119043|Rhodobiaceae	28211|Alphaproteobacteria	U	Bacterial type II and III secretion system protein	cpaC	-	-	ko:K02280	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	BON,Secretin,T2SS-T3SS_pil_N
SHD2_k127_527676_44	1282876.BAOK01000001_gene3381	1.188e-30	129.0	COG5461@1|root,COG5461@2|Bacteria,1MWWE@1224|Proteobacteria,2TU2Q@28211|Alphaproteobacteria,4BSTH@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	M	Pilus biogenesis CpaD protein (pilus_cpaD)	cpaD	-	-	ko:K02281	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Pilus_CpaD
SHD2_k127_527676_6	402881.Plav_0235	4.879e-159	511.0	COG4963@1|root,COG4963@2|Bacteria,1MWNY@1224|Proteobacteria,2TUDS@28211|Alphaproteobacteria,1JND6@119043|Rhodobiaceae	28211|Alphaproteobacteria	U	Pilus assembly protein	cpaE	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	AAA_31,CBP_BcsQ
SHD2_k127_527676_1	402881.Plav_0236	4.957e-236	737.0	COG4962@1|root,COG4962@2|Bacteria,1R7EN@1224|Proteobacteria,2TRNT@28211|Alphaproteobacteria,1JNMV@119043|Rhodobiaceae	28211|Alphaproteobacteria	U	Type II/IV secretion system protein	cpaF	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
SHD2_k127_527676_23	1282876.BAOK01000001_gene3378	1.049e-86	299.0	COG4965@1|root,COG4965@2|Bacteria,1MUXK@1224|Proteobacteria,2TRBI@28211|Alphaproteobacteria,4BQ57@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	U	Type II secretion system (T2SS), protein F	tadB	-	-	ko:K12510	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
SHD2_k127_527676_20	402881.Plav_0238	5.121e-101	338.0	COG2064@1|root,COG2064@2|Bacteria,1MWAZ@1224|Proteobacteria,2TSFA@28211|Alphaproteobacteria,1JNMX@119043|Rhodobiaceae	28211|Alphaproteobacteria	NU	Type II secretion system (T2SS), protein F	tadC	-	-	ko:K12511	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
SHD2_k127_527676_47	1122613.ATUP01000001_gene2016	1.082e-19	102.0	COG5010@1|root,COG5010@2|Bacteria,1MVTK@1224|Proteobacteria,2TVBA@28211|Alphaproteobacteria,43XWI@69657|Hyphomonadaceae	28211|Alphaproteobacteria	U	COG0457 FOG TPR repeat	MA20_18455	-	-	-	-	-	-	-	-	-	-	-	TPR_10,TPR_12,TPR_16,TPR_19,TPR_2,TPR_4,TPR_8
SHD2_k127_527676_35	1207063.P24_02181	1.379e-67	243.0	COG2358@1|root,COG2358@2|Bacteria,1MXW1@1224|Proteobacteria,2TSK2@28211|Alphaproteobacteria,2JPCR@204441|Rhodospirillales	204441|Rhodospirillales	S	NMT1-like family	-	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
SHD2_k127_527676_38	414684.RC1_2329	1.489e-55	215.0	COG0625@1|root,COG0625@2|Bacteria,1PHM1@1224|Proteobacteria,2TTQZ@28211|Alphaproteobacteria,2JRW7@204441|Rhodospirillales	204441|Rhodospirillales	O	Glutathione S-transferase	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C_2,GST_N_2,GST_N_3
SHD2_k127_527676_7	316056.RPC_3720	3.938e-154	499.0	COG0260@1|root,COG0260@2|Bacteria,1MUIN@1224|Proteobacteria,2TSI6@28211|Alphaproteobacteria,3JTK4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Belongs to the peptidase M17 family	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17
SHD2_k127_527676_33	1120983.KB894571_gene2224	1.433e-69	245.0	COG0791@1|root,COG0791@2|Bacteria,1MW03@1224|Proteobacteria,2TSFG@28211|Alphaproteobacteria,1JNVZ@119043|Rhodobiaceae	28211|Alphaproteobacteria	M	NlpC/P60 family	-	-	-	-	-	-	-	-	-	-	-	-	NLPC_P60,SH3_3
SHD2_k127_527676_29	1217720.ALOX01000011_gene2560	5.709e-81	280.0	COG0111@1|root,COG0111@2|Bacteria,1MW1U@1224|Proteobacteria,2TSUU@28211|Alphaproteobacteria,2JPHD@204441|Rhodospirillales	204441|Rhodospirillales	EH	D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain	-	-	1.1.1.79,1.1.1.81	ko:K12972	ko00260,ko00620,ko00630,ko01100,ko01110,ko01120,map00260,map00620,map00630,map01100,map01110,map01120	-	R00465,R01388,R01392,R02527	RC00031,RC00042,RC00670	ko00000,ko00001,ko01000	-	-	-	2-Hacid_dh_C
SHD2_k127_527676_39	1382303.JPOM01000001_gene2232	7.538e-52	192.0	COG3474@1|root,COG3474@2|Bacteria,1RIDN@1224|Proteobacteria,2U142@28211|Alphaproteobacteria,2KGGW@204458|Caulobacterales	204458|Caulobacterales	C	PFAM cytochrome c class I	-	-	-	ko:K08738	ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	3.D.4.6	-	-	Cytochrom_C
SHD2_k127_527676_21	1279038.KB907342_gene2676	5.017e-98	327.0	COG1212@1|root,COG1212@2|Bacteria,1MUUU@1224|Proteobacteria,2TUQM@28211|Alphaproteobacteria,2JPST@204441|Rhodospirillales	204441|Rhodospirillales	M	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria	kdsB	-	2.7.7.38	ko:K00979	ko00540,ko01100,map00540,map01100	M00063	R03351,R11396	RC00152,RC00910	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_3
SHD2_k127_527676_17	402881.Plav_0252	1.147e-108	359.0	COG0077@1|root,COG0077@2|Bacteria,1MU60@1224|Proteobacteria,2TSUT@28211|Alphaproteobacteria,1JNHD@119043|Rhodobiaceae	28211|Alphaproteobacteria	E	Prephenate dehydratase	pheA	-	4.2.1.51	ko:K04518	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024	R00691,R01373	RC00360	ko00000,ko00001,ko00002,ko01000	-	-	-	PDT
SHD2_k127_527676_37	266834.SMc03107	1.435e-63	226.0	COG1670@1|root,COG1670@2|Bacteria,1NNTH@1224|Proteobacteria	1224|Proteobacteria	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	GNAT_acetyltran
SHD2_k127_527676_19	1333998.M2A_1814	8.278e-103	343.0	COG2816@1|root,COG2816@2|Bacteria,1QGCX@1224|Proteobacteria,2TVMG@28211|Alphaproteobacteria,4BQFR@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	L	NADH pyrophosphatase-like rudimentary NUDIX domain	nudC	-	3.6.1.22	ko:K03426	ko00760,ko01100,ko04146,map00760,map01100,map04146	-	R00103,R03004,R11104	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX,NUDIX-like,zf-NADH-PPase
SHD2_k127_527676_3	1231392.OCGS_1753	2.657e-179	578.0	COG2812@1|root,COG2812@2|Bacteria,1MVCK@1224|Proteobacteria,2TRPB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3,DUF3646
SHD2_k127_527676_28	314254.OA2633_13230	7.322e-82	276.0	COG0353@1|root,COG0353@2|Bacteria,1MV9Q@1224|Proteobacteria,2TRZM@28211|Alphaproteobacteria,43XFW@69657|Hyphomonadaceae	28211|Alphaproteobacteria	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	-	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecR,Toprim_4
SHD2_k127_527676_27	384765.SIAM614_04720	8.942e-85	294.0	COG1322@1|root,COG1322@2|Bacteria,1MWHV@1224|Proteobacteria,2TTX6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein conserved in bacteria	rmuC	-	-	ko:K09760	-	-	-	-	ko00000	-	-	-	RmuC
SHD2_k127_527676_36	1333998.M2A_1807	9.125e-66	229.0	COG0242@1|root,COG0242@2|Bacteria,1RA2P@1224|Proteobacteria,2U797@28211|Alphaproteobacteria,4BQGS@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0018193,GO:0018206,GO:0019538,GO:0031365,GO:0036211,GO:0042586,GO:0043170,GO:0043412,GO:0043686,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564	3.5.1.31,3.5.1.88	ko:K01450,ko:K01462	ko00270,ko00630,map00270,map00630	-	R00653	RC00165,RC00323	ko00000,ko00001,ko01000	-	-	-	Pep_deformylase
SHD2_k127_527676_15	402881.Plav_0262	3.458e-111	366.0	COG0223@1|root,COG0223@2|Bacteria,1MU4Q@1224|Proteobacteria,2TSWX@28211|Alphaproteobacteria,1JNFH@119043|Rhodobiaceae	28211|Alphaproteobacteria	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
SHD2_k127_527676_16	1120956.JHZK01000038_gene1898	2.277e-109	358.0	COG0101@1|root,COG0101@2|Bacteria,1MUYI@1224|Proteobacteria,2TR57@28211|Alphaproteobacteria,1JN2V@119043|Rhodobiaceae	28211|Alphaproteobacteria	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
SHD2_k127_527676_31	402881.Plav_0264	2.509e-78	271.0	COG0796@1|root,COG0796@2|Bacteria,1NAI2@1224|Proteobacteria,2TSR7@28211|Alphaproteobacteria,1JNSR@119043|Rhodobiaceae	28211|Alphaproteobacteria	M	Provides the (R)-glutamate required for cell wall biosynthesis	murI	-	5.1.1.3	ko:K01776	ko00471,ko01100,map00471,map01100	-	R00260	RC00302	ko00000,ko00001,ko01000,ko01011	-	-	-	Asp_Glu_race
SHD2_k127_527676_8	1121033.AUCF01000005_gene5390	9.36e-150	483.0	COG0624@1|root,COG0624@2|Bacteria,1MW6G@1224|Proteobacteria,2TT0J@28211|Alphaproteobacteria,2JQ29@204441|Rhodospirillales	204441|Rhodospirillales	E	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls	dapE	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
SHD2_k127_527676_30	366602.Caul_4827	3.578e-80	279.0	COG1028@1|root,COG1028@2|Bacteria,1R4GD@1224|Proteobacteria,2TVNF@28211|Alphaproteobacteria,2KFS3@204458|Caulobacterales	204458|Caulobacterales	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
SHD2_k127_527676_50	1038866.KB902797_gene92	0.0001373	48.0	COG3152@1|root,COG3152@2|Bacteria,1NDNG@1224|Proteobacteria,2TT9F@28211|Alphaproteobacteria,3JVMI@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF805)	-	-	-	-	-	-	-	-	-	-	-	-	DUF805
SHD2_k127_527676_51	318996.AXAZ01000051_gene3908	0.0002229	48.0	COG3152@1|root,COG3152@2|Bacteria,1NDNG@1224|Proteobacteria,2TT9F@28211|Alphaproteobacteria,3JVMI@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF805)	-	-	-	-	-	-	-	-	-	-	-	-	DUF805
SHD2_k127_527676_12	420324.KI912031_gene2818	7.503e-126	409.0	COG2171@1|root,COG2171@2|Bacteria,1MU0Y@1224|Proteobacteria,2TS3H@28211|Alphaproteobacteria,1JTVX@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	PFAM transferase hexapeptide repeat containing protein	dapD	-	2.3.1.117	ko:K00674	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R04365	RC00004,RC01136	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,Hexapep_2,THDPS_N_2
SHD2_k127_527676_40	1114964.L485_14225	1.388e-49	184.0	COG1011@1|root,COG1011@2|Bacteria,1PHPQ@1224|Proteobacteria,2TUDN@28211|Alphaproteobacteria,2KEBI@204457|Sphingomonadales	204457|Sphingomonadales	S	Hydrolase	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
SHD2_k127_527676_24	402881.Plav_0295	2.877e-85	297.0	COG5330@1|root,COG5330@2|Bacteria,1R4CF@1224|Proteobacteria,2TYQC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Uncharacterised protein conserved in bacteria (DUF2336)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2336
SHD2_k127_527676_41	1280954.HPO_01717	1.638e-49	190.0	COG3409@1|root,COG5480@1|root,COG3409@2|Bacteria,COG5480@2|Bacteria,1P9ZA@1224|Proteobacteria,2TSTF@28211|Alphaproteobacteria,43XAM@69657|Hyphomonadaceae	28211|Alphaproteobacteria	M	Protein of unknown function (DUF1036)	MA20_21840	-	-	-	-	-	-	-	-	-	-	-	DUF1036,PG_binding_1
SHD2_k127_527676_13	1282876.BAOK01000001_gene3339	5.712e-116	380.0	COG0548@1|root,COG0548@2|Bacteria,1MU17@1224|Proteobacteria,2TQQS@28211|Alphaproteobacteria,4BPEF@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
SHD2_k127_527676_34	269796.Rru_A3340	4.729e-68	238.0	COG0218@1|root,COG0218@2|Bacteria,1MY3Z@1224|Proteobacteria,2U5E5@28211|Alphaproteobacteria,2JRTK@204441|Rhodospirillales	204441|Rhodospirillales	D	Necessary for normal cell division and for the maintenance of normal septation	engB	-	-	ko:K03978	-	-	-	-	ko00000,ko03036	-	-	-	MMR_HSR1
SHD2_k127_527676_2	419610.Mext_2351	7.164e-189	607.0	COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,2TSTJ@28211|Alphaproteobacteria,1JS60@119045|Methylobacteriaceae	28211|Alphaproteobacteria	U	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins	yidC	GO:0002790,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032940,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP,YidC_periplas
SHD2_k127_527676_46	762968.HMPREF9441_01227	3.951e-23	105.0	COG0759@1|root,COG0759@2|Bacteria,4NV1N@976|Bacteroidetes,2FTU6@200643|Bacteroidia	976|Bacteroidetes	S	Could be involved in insertion of integral membrane proteins into the membrane	yidD	-	-	ko:K08998	-	-	-	-	ko00000	-	-	-	Haemolytic
SHD2_k127_527676_45	1112212.JH584235_gene3477	2.088e-26	115.0	COG0594@1|root,COG0594@2|Bacteria,1N6QY@1224|Proteobacteria,2UFAB@28211|Alphaproteobacteria,2K5Y4@204457|Sphingomonadales	204457|Sphingomonadales	J	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme	rnpA	-	3.1.26.5	ko:K03536	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_P
SHD2_k127_527676_14	402881.Plav_0305	6.309e-112	379.0	COG0642@1|root,COG0642@2|Bacteria,1QYPP@1224|Proteobacteria,2TXUU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
SHD2_k127_527676_26	1430440.MGMSRv2_3857	7.251e-85	288.0	COG4106@1|root,COG4106@2|Bacteria,1Q2Y3@1224|Proteobacteria,2TU5T@28211|Alphaproteobacteria,2JS7E@204441|Rhodospirillales	204441|Rhodospirillales	S	trans-aconitate	tam	-	2.1.1.144	ko:K00598	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_23,Methyltransf_25
SHD2_k127_527676_4	1380391.JIAS01000020_gene1513	5.166e-177	571.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2TR49@28211|Alphaproteobacteria,2JR2R@204441|Rhodospirillales	204441|Rhodospirillales	E	Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
SHD2_k127_527676_18	450851.PHZ_c0447	1.076e-106	356.0	COG3191@1|root,COG3191@2|Bacteria,1MWDP@1224|Proteobacteria,2TRDC@28211|Alphaproteobacteria,2KFJX@204458|Caulobacterales	204458|Caulobacterales	EQ	Peptidase family S58	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S58
SHD2_k127_527676_22	1003200.AXXA_04313	9.266e-98	327.0	COG0412@1|root,COG0412@2|Bacteria,1MW7S@1224|Proteobacteria,2VH0T@28216|Betaproteobacteria,3T4W3@506|Alcaligenaceae	28216|Betaproteobacteria	Q	Dienelactone hydrolase and related enzymes	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
SHD2_k127_527676_32	1333998.M2A_1786	1.517e-71	259.0	28HAG@1|root,2Z7MV@2|Bacteria,1PMGH@1224|Proteobacteria,2U27X@28211|Alphaproteobacteria,4BRZZ@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_527676_49	1087481.AGFX01000013_gene3067	7.543e-05	51.0	2BKI8@1|root,32EZF@2|Bacteria,1TZNM@1239|Firmicutes,4I8XU@91061|Bacilli,270PJ@186822|Paenibacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_527676_9	1292034.OR37_02706	3.77e-146	473.0	COG3268@1|root,COG3268@2|Bacteria,1MVI3@1224|Proteobacteria,2TV1G@28211|Alphaproteobacteria,2KHUE@204458|Caulobacterales	204458|Caulobacterales	S	Saccharopine dehydrogenase NADP binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Sacchrp_dh_NADP
SHD2_k127_527676_5	113395.AXAI01000013_gene6712	5.784e-174	554.0	COG2124@1|root,COG2124@2|Bacteria,1MV8Q@1224|Proteobacteria,2TRWW@28211|Alphaproteobacteria,3JR28@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Cytochrome P450	MA20_04500	-	-	-	-	-	-	-	-	-	-	-	p450
SHD2_k127_527676_42	1267005.KB911260_gene3526	1.16e-44	165.0	COG0727@1|root,COG0727@2|Bacteria,1N5PC@1224|Proteobacteria,2UFEE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
SHD2_k127_527676_10	450851.PHZ_c1120	1.285e-143	463.0	COG0596@1|root,COG0596@2|Bacteria,1N5ZI@1224|Proteobacteria,2TS7X@28211|Alphaproteobacteria,2KITC@204458|Caulobacterales	204458|Caulobacterales	S	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
SHD2_k127_527676_11	626887.J057_10026	1.974e-138	452.0	COG3525@1|root,COG3525@2|Bacteria,1QR2G@1224|Proteobacteria,1RZNM@1236|Gammaproteobacteria,466IG@72275|Alteromonadaceae	1236|Gammaproteobacteria	G	beta-N-acetylglucosaminidase	-	-	3.2.1.35	ko:K01197	ko00531,ko01100,map00531,map01100	M00076,M00077	R07824,R07825,R10905	-	ko00000,ko00001,ko00002,ko00536,ko00537,ko01000,ko02042	-	-	-	Glyco_hydro_20b,NAGidase
SHD2_k127_527676_25	69395.JQLZ01000017_gene4235	3.591e-85	305.0	2EDFD@1|root,337BN@2|Bacteria,1NFQX@1224|Proteobacteria,2V5MW@28211|Alphaproteobacteria,2KHQA@204458|Caulobacterales	204458|Caulobacterales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_527676_0	1163407.UU7_03772	0.0	1269.0	COG0726@1|root,COG1215@1|root,COG3858@1|root,COG0726@2|Bacteria,COG1215@2|Bacteria,COG3858@2|Bacteria,1MXG7@1224|Proteobacteria,1RMS4@1236|Gammaproteobacteria,1X351@135614|Xanthomonadales	135614|Xanthomonadales	M	in Yersinia the HmsR protein is an inner membrane protein	hmsR	-	-	ko:K11936	ko02026,map02026	-	-	-	ko00000,ko00001,ko01000,ko01003,ko02000	4.D.1.1.2,4.D.1.1.3	GT2	-	Glyco_hydro_18,Glyco_tranf_2_3,Polysacc_deac_1
SHD2_k127_527676_43	579138.Zymop_1336	2.12e-40	165.0	COG1287@1|root,COG1287@2|Bacteria,1N2R1@1224|Proteobacteria,2UEBP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	oligosaccharyl transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	GT87
SHD2_k127_5288766_25	69395.JQLZ01000009_gene1932	1.479e-25	114.0	COG2854@1|root,COG2854@2|Bacteria,1NKFA@1224|Proteobacteria,2UJ76@28211|Alphaproteobacteria,2KK2Y@204458|Caulobacterales	204458|Caulobacterales	Q	PFAM toluene tolerance family protein	-	-	-	ko:K07323	ko02010,map02010	M00210	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27.3	-	-	MlaC
SHD2_k127_5288766_27	572477.Alvin_0005	2.853e-23	112.0	2AJGQ@1|root,31A34@2|Bacteria,1NDT9@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_5288766_37	555793.WSK_3164	2.536e-09	63.0	COG5323@1|root,COG5323@2|Bacteria,1MW8S@1224|Proteobacteria,2TREI@28211|Alphaproteobacteria,2K2BG@204457|Sphingomonadales	204457|Sphingomonadales	S	Terminase RNaseH-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Terminase_6,Terminase_6C
SHD2_k127_5288766_4	1510531.JQJJ01000016_gene3171	1.501e-154	512.0	COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,2TQQ8@28211|Alphaproteobacteria,3JR5K@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Penicillin-binding Protein	pbpC	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
SHD2_k127_5288766_8	1333998.M2A_1638	1.172e-124	407.0	COG0715@1|root,COG0715@2|Bacteria,1MXA3@1224|Proteobacteria,2TTW8@28211|Alphaproteobacteria,4BPUD@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	P	NMT1/THI5 like	MA20_40330	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
SHD2_k127_5288766_16	190650.CC_1048	2.974e-81	284.0	COG1506@1|root,COG1506@2|Bacteria,1MUJ3@1224|Proteobacteria,2TUZZ@28211|Alphaproteobacteria,2KFCI@204458|Caulobacterales	204458|Caulobacterales	E	Prolyl oligopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S9
SHD2_k127_5288766_36	394221.Mmar10_3063	5.916e-13	81.0	COG1506@1|root,COG1506@2|Bacteria,1MUJ3@1224|Proteobacteria,2TUZZ@28211|Alphaproteobacteria,43W55@69657|Hyphomonadaceae	28211|Alphaproteobacteria	E	Peptidase S9 prolyl oligopeptidase active site	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S9
SHD2_k127_5288766_44	1081640.AGFU01000009_gene1364	0.0002502	51.0	2B26F@1|root,31UPS@2|Bacteria,1QSJK@1224|Proteobacteria,2V1G3@28211|Alphaproteobacteria,2KBHW@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_5288766_15	1510531.JQJJ01000009_gene924	2.216e-81	278.0	COG1116@1|root,COG1116@2|Bacteria,1MUIM@1224|Proteobacteria,2TRHM@28211|Alphaproteobacteria,3JQMP@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
SHD2_k127_5288766_34	1532558.JL39_11755	1.904e-15	81.0	COG3514@1|root,COG3514@2|Bacteria,1NGCR@1224|Proteobacteria,2UFX3@28211|Alphaproteobacteria,4BG7K@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	BrnA antitoxin of type II toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	BrnA_antitoxin
SHD2_k127_5288766_33	665942.HMPREF1022_00545	5.615e-16	80.0	COG2929@1|root,COG2929@2|Bacteria,1NG9V@1224|Proteobacteria,43B9M@68525|delta/epsilon subdivisions,2X6NR@28221|Deltaproteobacteria,2MH4Y@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Ribonuclease toxin, BrnT, of type II toxin-antitoxin system	-	-	-	ko:K09803	-	-	-	-	ko00000	-	-	-	BrnT_toxin
SHD2_k127_5288766_13	1282876.BAOK01000001_gene2606	1.531e-96	323.0	COG0600@1|root,COG0600@2|Bacteria,1MVAE@1224|Proteobacteria,2TSP5@28211|Alphaproteobacteria,4BPXV@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	MA20_40340	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
SHD2_k127_5288766_35	522306.CAP2UW1_1698	6.909e-14	81.0	COG4679@1|root,COG4679@2|Bacteria,1MZC9@1224|Proteobacteria,2VTTD@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Phage derived protein Gp49-like (DUF891)	-	-	-	-	-	-	-	-	-	-	-	-	Gp49
SHD2_k127_5288766_6	1037409.BJ6T_25580	3.741e-136	447.0	COG0477@1|root,COG2814@2|Bacteria,1QTW0@1224|Proteobacteria,2TSC6@28211|Alphaproteobacteria,3JVT2@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EGP	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
SHD2_k127_5288766_41	189753.AXAS01000086_gene6878	2.593e-06	55.0	COG0790@1|root,COG0790@2|Bacteria,1MWPA@1224|Proteobacteria,2TR2B@28211|Alphaproteobacteria,3JXQP@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Sel1-like repeats.	-	-	-	ko:K07126	-	-	-	-	ko00000	-	-	-	Sel1
SHD2_k127_5288766_21	1282876.BAOK01000001_gene3168	2.872e-46	179.0	COG2050@1|root,COG2050@2|Bacteria,1RDVV@1224|Proteobacteria,2UANF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	protein, possibly involved in aromatic compounds catabolism	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
SHD2_k127_5288766_24	1123257.AUFV01000003_gene1193	3.032e-27	122.0	2DNX2@1|root,32ZMB@2|Bacteria,1ND3X@1224|Proteobacteria,1SD5R@1236|Gammaproteobacteria,1XBKZ@135614|Xanthomonadales	135614|Xanthomonadales	S	Protein of unknown function (DUF2834)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2834
SHD2_k127_5288766_5	247634.GPB2148_1166	4.884e-151	484.0	COG0657@1|root,COG0657@2|Bacteria,1NRN8@1224|Proteobacteria,1SK0Q@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Carboxylesterase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3
SHD2_k127_5288766_32	1282876.BAOK01000001_gene2608	8.642e-18	88.0	2EG12@1|root,339T3@2|Bacteria,1NGID@1224|Proteobacteria,2UK0A@28211|Alphaproteobacteria,4BSUA@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF2849)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2849
SHD2_k127_5288766_0	402881.Plav_0889	7.579e-244	766.0	COG0155@1|root,COG0155@2|Bacteria,1MVVB@1224|Proteobacteria,2TRCR@28211|Alphaproteobacteria,1JNM8@119043|Rhodobiaceae	28211|Alphaproteobacteria	C	Nitrite and sulphite reductase 4Fe-4S domain	cysI	-	1.8.1.2	ko:K00381	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R00858	RC00065	ko00000,ko00001,ko00002,ko01000	-	-	-	NIR_SIR,NIR_SIR_ferr
SHD2_k127_5288766_22	1123366.TH3_10491	3.812e-40	156.0	COG3749@1|root,COG3749@2|Bacteria,1RJR9@1224|Proteobacteria,2UDH7@28211|Alphaproteobacteria,2JTNM@204441|Rhodospirillales	204441|Rhodospirillales	S	Bacterial protein of unknown function (DUF934)	-	-	-	-	-	-	-	-	-	-	-	-	DUF934
SHD2_k127_5288766_43	268739.Nmlp_1116	8.055e-05	46.0	arCOG00818@1|root,arCOG00818@2157|Archaea,2Y0IT@28890|Euryarchaeota,23XYH@183963|Halobacteria	183963|Halobacteria	K	SpoVT / AbrB like domain	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin
SHD2_k127_5288766_10	1234364.AMSF01000082_gene2993	2.124e-118	401.0	COG0477@1|root,COG2814@2|Bacteria,1QTW0@1224|Proteobacteria,1T2CZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	EGP	Major Facilitator	proP	-	-	ko:K03762	-	-	-	-	ko00000,ko02000	2.A.1.6.4	-	iJN746.PP_2703	MFS_1,Sugar_tr
SHD2_k127_5288766_3	685778.AORL01000004_gene3458	1.563e-160	513.0	COG4638@1|root,COG4638@2|Bacteria,1MXR2@1224|Proteobacteria,2U4GA@28211|Alphaproteobacteria,2K6YQ@204457|Sphingomonadales	204457|Sphingomonadales	P	Rieske [2Fe-2S] domain	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
SHD2_k127_5288766_7	1280944.HY17_11960	3.926e-126	418.0	COG2124@1|root,COG2124@2|Bacteria,1MY5H@1224|Proteobacteria,2TTRR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	cytochrome P450	pksS	-	1.14.14.1	ko:K00493	ko00071,ko00380,ko00627,ko01120,map00071,map00380,map00627,map01120	-	R03629,R04121,R05259	RC00046,RC01311	ko00000,ko00001,ko01000	-	-	-	p450
SHD2_k127_5288766_12	402881.Plav_2895	1.232e-101	344.0	COG0019@1|root,COG0019@2|Bacteria,1MZ7Y@1224|Proteobacteria,2TSKB@28211|Alphaproteobacteria,1JN0I@119043|Rhodobiaceae	28211|Alphaproteobacteria	E	Pyridoxal-dependent decarboxylase, pyridoxal binding domain	ldc	-	4.1.1.17	ko:K01581	ko00330,ko00480,ko01100,ko01110,ko01130,map00330,map00480,map01100,map01110,map01130	M00134	R00670	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
SHD2_k127_5288766_30	292.DM42_6039	3.281e-20	92.0	2EIDG@1|root,33C4V@2|Bacteria,1N0P4@1224|Proteobacteria,2VYCP@28216|Betaproteobacteria,1K9BA@119060|Burkholderiaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_5288766_42	1333998.M2A_1627	5.234e-06	56.0	COG5330@1|root,COG5330@2|Bacteria,1R3VY@1224|Proteobacteria,2TUQ8@28211|Alphaproteobacteria,4BRQJ@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Uncharacterised protein conserved in bacteria (DUF2336)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2336
SHD2_k127_5288766_1	1205680.CAKO01000002_gene2577	1.121e-224	707.0	COG4108@1|root,COG4108@2|Bacteria,1MU7X@1224|Proteobacteria,2TRP5@28211|Alphaproteobacteria,2JPYB@204441|Rhodospirillales	204441|Rhodospirillales	J	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP	prfC	-	-	ko:K02837	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,RF3_C
SHD2_k127_5288766_19	240015.ACP_3304	9.292e-61	216.0	COG3548@1|root,COG3548@2|Bacteria,3Y607@57723|Acidobacteria,2JMVT@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein of unknown function (DUF1211)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1211
SHD2_k127_5288766_39	1284708.HMPREF1634_05900	3.856e-08	59.0	COG0454@1|root,COG0454@2|Bacteria,1V1JN@1239|Firmicutes,24C53@186801|Clostridia	186801|Clostridia	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_7
SHD2_k127_5288766_26	402881.Plav_0880	2.831e-25	110.0	COG5447@1|root,COG5447@2|Bacteria,1N1KU@1224|Proteobacteria,2UCBQ@28211|Alphaproteobacteria,1JPDP@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1491)	MA20_15690	-	-	-	-	-	-	-	-	-	-	-	DUF1491
SHD2_k127_5288766_29	1210884.HG799464_gene10689	1.281e-20	100.0	COG4403@1|root,COG4403@2|Bacteria	2|Bacteria	V	Lanthionine synthetase C family protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_5288766_11	859657.RPSI07_1864	1.02e-113	386.0	COG2211@1|root,COG2211@2|Bacteria,1NR4C@1224|Proteobacteria,2W1HW@28216|Betaproteobacteria,1K6BU@119060|Burkholderiaceae	28216|Betaproteobacteria	G	MFS_1 like family	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SHD2_k127_5288766_14	1122132.AQYH01000010_gene3800	1.113e-90	320.0	COG0642@1|root,COG2205@2|Bacteria,1RCSX@1224|Proteobacteria,2U5U3@28211|Alphaproteobacteria,4B9U2@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Histidine kinase	divJ	-	2.7.13.3	ko:K11357	ko02020,ko04112,map02020,map04112	M00511	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA
SHD2_k127_5288766_18	331869.BAL199_14332	1.004e-69	257.0	COG0642@1|root,COG5002@1|root,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,2TRHH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_7,PAS_9
SHD2_k127_5288766_2	1158292.JPOE01000002_gene3799	9.077e-215	674.0	COG3256@1|root,COG3256@2|Bacteria,1MVT1@1224|Proteobacteria,2VHXU@28216|Betaproteobacteria,1KJTB@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Belongs to the heme-copper respiratory oxidase family	norB	-	1.7.2.5	ko:K04561	ko00910,ko01120,map00910,map01120	M00529	R00294	RC02794	ko00000,ko00001,ko00002,ko01000	3.D.4.10	-	-	COX1
SHD2_k127_5288766_17	1158292.JPOE01000002_gene3798	6.787e-77	262.0	COG2010@1|root,COG2010@2|Bacteria,1RDSI@1224|Proteobacteria,2VQ50@28216|Betaproteobacteria,1KKR7@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Cytochrome c	norC	-	-	ko:K02305	ko00910,ko01120,map00910,map01120	M00529	R00294	RC02794	ko00000,ko00001,ko00002	3.D.4.10	-	-	Cytochrom_C
SHD2_k127_5288766_20	1207063.P24_00705	1.171e-59	210.0	COG2030@1|root,COG2030@2|Bacteria,1R4VU@1224|Proteobacteria,2U1U9@28211|Alphaproteobacteria,2JWEB@204441|Rhodospirillales	204441|Rhodospirillales	I	N-terminal half of MaoC dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
SHD2_k127_5288766_23	1333998.M2A_1619	5.363e-40	158.0	COG0583@1|root,COG0583@2|Bacteria,1MXC9@1224|Proteobacteria,2TTTY@28211|Alphaproteobacteria,4BSAT@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	K	DNA-binding transcription factor activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_5288766_31	1123503.KB908058_gene911	2.049e-19	92.0	COG0593@1|root,COG0593@2|Bacteria,1N76V@1224|Proteobacteria,2UG3R@28211|Alphaproteobacteria,2KHAR@204458|Caulobacterales	204458|Caulobacterales	L	PFAM Chromosomal replication initiator DnaA domain	-	-	-	-	-	-	-	-	-	-	-	-	Bac_DnaA_C
SHD2_k127_5288766_9	666684.AfiDRAFT_1834	1.286e-119	392.0	COG3677@1|root,COG3677@2|Bacteria,1MXYX@1224|Proteobacteria,2TQR3@28211|Alphaproteobacteria,3JU79@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	ISXO2-like transposase domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS1595,Zn_Tnp_IS1595
SHD2_k127_5291528_16	1472716.KBK24_0114960	9.356e-52	197.0	COG2020@1|root,COG2020@2|Bacteria,1RDC4@1224|Proteobacteria,2WFGW@28216|Betaproteobacteria,1K11B@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Isoprenylcysteine carboxyl methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
SHD2_k127_5291528_8	1333998.M2A_3068	2.511e-122	397.0	COG1692@1|root,COG1692@2|Bacteria,1MW12@1224|Proteobacteria,2TS4S@28211|Alphaproteobacteria,4BP82@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	YmdB-like protein	MA20_17970	GO:0003674,GO:0003824,GO:0004112,GO:0004113,GO:0008081,GO:0016787,GO:0016788,GO:0042578	-	ko:K09769	-	-	-	-	ko00000	-	-	-	YmdB
SHD2_k127_5291528_10	1245469.S58_20040	1.041e-93	314.0	COG3384@1|root,COG3384@2|Bacteria,1MXJZ@1224|Proteobacteria,2TRJT@28211|Alphaproteobacteria,3JW10@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Catalytic LigB subunit of aromatic ring-opening dioxygenase	MA20_02555	-	-	ko:K15777	ko00965,map00965	-	R08836	RC00387	ko00000,ko00001,ko01000	-	-	-	LigB
SHD2_k127_5291528_18	84531.JMTZ01000106_gene1468	7.933e-47	174.0	COG0346@1|root,COG0346@2|Bacteria,1RHD4@1224|Proteobacteria,1S67S@1236|Gammaproteobacteria,1X75K@135614|Xanthomonadales	135614|Xanthomonadales	E	Lactoylglutathione lyase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
SHD2_k127_5291528_23	1031711.RSPO_c02379	1.024e-34	141.0	COG0625@1|root,COG3832@1|root,COG0625@2|Bacteria,COG3832@2|Bacteria,1RC4Y@1224|Proteobacteria,2VW3S@28216|Betaproteobacteria,1KH88@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Glutathione S-transferase	gstF	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	AHSA1,GST_C,GST_N,GST_N_3
SHD2_k127_5291528_9	652103.Rpdx1_1264	1.143e-97	325.0	COG0217@1|root,COG0217@2|Bacteria,1MW3X@1224|Proteobacteria,2TRSK@28211|Alphaproteobacteria,3JRDF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	transcriptional regulatory protein	MA20_17930	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
SHD2_k127_5291528_17	426117.M446_2328	5.203e-47	174.0	COG0817@1|root,COG0817@2|Bacteria,1MUJI@1224|Proteobacteria,2U70Z@28211|Alphaproteobacteria,1JT6W@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group	ruvC	GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
SHD2_k127_5291528_15	1101192.KB910516_gene3841	6.24e-52	199.0	COG0632@1|root,COG0632@2|Bacteria,1MWJR@1224|Proteobacteria,2TSKM@28211|Alphaproteobacteria,1JRAP@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB	ruvA	GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
SHD2_k127_5291528_6	1282876.BAOK01000001_gene1071	9.69e-156	497.0	COG2255@1|root,COG2255@2|Bacteria,1MU38@1224|Proteobacteria,2TQNG@28211|Alphaproteobacteria,4BPWK@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
SHD2_k127_5291528_21	402881.Plav_2118	9.74e-41	156.0	COG0824@1|root,COG0824@2|Bacteria,1MZH6@1224|Proteobacteria,2UBYM@28211|Alphaproteobacteria,1JP7W@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Thioesterase-like superfamily	ybgC	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT
SHD2_k127_5291528_12	1380391.JIAS01000013_gene3669	3.159e-75	264.0	COG0811@1|root,COG0811@2|Bacteria,1NCWW@1224|Proteobacteria,2TQXQ@28211|Alphaproteobacteria,2JPCG@204441|Rhodospirillales	204441|Rhodospirillales	U	COG0811 Biopolymer transport proteins	tolQ	-	-	ko:K03562	ko01120,map01120	-	-	-	ko00000,ko02000	1.A.30.2.2	-	-	MotA_ExbB
SHD2_k127_5291528_20	438753.AZC_0522	1.124e-44	171.0	COG0848@1|root,COG0848@2|Bacteria,1MZ6M@1224|Proteobacteria,2UA46@28211|Alphaproteobacteria,3EZDD@335928|Xanthobacteraceae	28211|Alphaproteobacteria	U	Biopolymer transport protein	tolR	-	-	ko:K03559,ko:K03560	-	-	-	-	ko00000,ko02000	1.A.30.2.1,1.A.30.2.2	-	-	ExbD
SHD2_k127_5291528_26	1282876.BAOK01000001_gene1075	2.825e-29	130.0	COG3170@1|root,COG3170@2|Bacteria,1QW53@1224|Proteobacteria,2TZ5Y@28211|Alphaproteobacteria,4BTFS@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	NU	TIGRFAM protein TolA	-	-	-	-	-	-	-	-	-	-	-	-	TonB_2
SHD2_k127_5291528_5	991905.SL003B_0924	4.269e-185	587.0	COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,2TR03@28211|Alphaproteobacteria,4BPJM@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	U	Involved in the TonB-independent uptake of proteins	tolB	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40,TolB_N
SHD2_k127_5291528_19	402881.Plav_2123	2.318e-45	169.0	COG2885@1|root,COG2885@2|Bacteria,1MZTV@1224|Proteobacteria,2U758@28211|Alphaproteobacteria,1JNYD@119043|Rhodobiaceae	28211|Alphaproteobacteria	M	OmpA family	pal	-	-	ko:K03640	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	OmpA
SHD2_k127_5291528_28	1220535.IMCC14465_12500	2.078e-22	109.0	COG1729@1|root,COG1729@2|Bacteria,1MUSV@1224|Proteobacteria,2U6ZQ@28211|Alphaproteobacteria,4BQWD@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	D	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division	cpoB	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6,TolA_bind_tri
SHD2_k127_5291528_14	1333998.M2A_3054	9.938e-68	244.0	COG0037@1|root,COG0037@2|Bacteria,1MU85@1224|Proteobacteria,2TRK1@28211|Alphaproteobacteria,4BQDU@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3
SHD2_k127_5291528_1	1333998.M2A_3053	6.752e-291	904.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,2TSYQ@28211|Alphaproteobacteria,4BPBS@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
SHD2_k127_5291528_11	1333998.M2A_3052	4.589e-93	313.0	COG0294@1|root,COG0294@2|Bacteria,1MUIR@1224|Proteobacteria,2TTMG@28211|Alphaproteobacteria,4BQ5K@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	folP	-	2.5.1.15,2.7.6.3	ko:K00796,ko:K13941,ko:K18824	ko00790,ko01100,map00790,map01100	M00126,M00840,M00841	R03066,R03067,R03503	RC00002,RC00017,RC00121,RC00842	ko00000,ko00001,ko00002,ko01000,ko01504	-	-	-	Pterin_bind
SHD2_k127_5291528_3	1282876.BAOK01000001_gene1082	2.223e-205	647.0	COG1109@1|root,COG1109@2|Bacteria,1MU24@1224|Proteobacteria,2TQWH@28211|Alphaproteobacteria,4BPC9@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	-	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
SHD2_k127_5291528_13	1248917.ANFX01000014_gene1374	2.057e-71	250.0	COG0351@1|root,COG0351@2|Bacteria,1MU9J@1224|Proteobacteria,2TUKR@28211|Alphaproteobacteria,2K24Q@204457|Sphingomonadales	204457|Sphingomonadales	H	Phosphomethylpyrimidine kinase	thiD	-	2.7.1.49,2.7.4.7	ko:K00941	ko00730,ko01100,map00730,map01100	M00127	R03471,R04509	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase,Phos_pyr_kin
SHD2_k127_5291528_7	402881.Plav_0826	1.191e-142	458.0	COG2070@1|root,COG2070@2|Bacteria,1MWPC@1224|Proteobacteria,2TQRT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	2-nitropropane dioxygenase	-	-	1.13.12.16,1.3.1.9	ko:K00459,ko:K02371	ko00061,ko00910,ko01100,ko01212,map00061,map00910,map01100,map01212	M00083	R00025,R04429,R04724,R04955,R04958,R04961,R04966,R04969,R07765	RC00052,RC00076,RC02541,RC02759	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	NMO
SHD2_k127_5291528_4	460265.Mnod_7581	3.157e-203	640.0	COG0104@1|root,COG0104@2|Bacteria,1MU5B@1224|Proteobacteria,2TRKY@28211|Alphaproteobacteria,1JRX5@119045|Methylobacteriaceae	28211|Alphaproteobacteria	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
SHD2_k127_5291528_2	1437824.BN940_14226	1.636e-255	801.0	COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,2VRSD@28216|Betaproteobacteria,3T726@506|Alcaligenaceae	28216|Betaproteobacteria	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,DAO,NAD_binding_8
SHD2_k127_5291528_0	1437824.BN940_14221	1.416e-297	919.0	COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,2VRSD@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,DAO,NAD_binding_8
SHD2_k127_5291528_22	1437824.BN940_14206	3.672e-36	139.0	COG0633@1|root,COG0633@2|Bacteria,1RHDC@1224|Proteobacteria,2VVNS@28216|Betaproteobacteria,3T890@506|Alcaligenaceae	28216|Betaproteobacteria	C	2Fe-2S iron-sulfur cluster binding domain	-	-	-	ko:K04755	-	-	-	-	ko00000	-	-	-	Fer2
SHD2_k127_5337882_1	316056.RPC_1733	0.0	1349.0	COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,2TRUB@28211|Alphaproteobacteria,3JUU5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase	dnaE2	GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496	2.7.7.7	ko:K02337,ko:K14162	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
SHD2_k127_5337882_18	335659.S23_49740	9.872e-164	530.0	COG0389@1|root,COG0389@2|Bacteria,1MU5X@1224|Proteobacteria,2TQVR@28211|Alphaproteobacteria,3JQX0@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	impB/mucB/samB family	MA20_15945	-	-	ko:K14161	-	-	-	-	ko00000,ko03400	-	-	-	IMS,IMS_C
SHD2_k127_5337882_67	1238182.C882_1002	5.054e-18	94.0	COG4544@1|root,COG4544@2|Bacteria,1MY56@1224|Proteobacteria,2TT91@28211|Alphaproteobacteria,2JTBE@204441|Rhodospirillales	204441|Rhodospirillales	S	SOS response	-	-	-	ko:K14160	-	-	-	-	ko00000,ko03400	-	-	-	-
SHD2_k127_5337882_52	633149.Bresu_0474	1.893e-56	206.0	COG1309@1|root,COG1309@2|Bacteria,1R6X5@1224|Proteobacteria,2U7EK@28211|Alphaproteobacteria,2KGFQ@204458|Caulobacterales	204458|Caulobacterales	K	regulatory protein TetR	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
SHD2_k127_5337882_24	1121937.AUHJ01000020_gene1271	4.758e-140	484.0	COG1629@1|root,COG1629@2|Bacteria,1R479@1224|Proteobacteria,1S16Z@1236|Gammaproteobacteria,4652F@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
SHD2_k127_5337882_4	402881.Plav_2519	5.78e-257	799.0	COG3119@1|root,COG3119@2|Bacteria,1MV0B@1224|Proteobacteria,2TRI6@28211|Alphaproteobacteria,1JPX5@119043|Rhodobiaceae	28211|Alphaproteobacteria	P	Sulfatase	pehA	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
SHD2_k127_5337882_23	69395.JQLZ01000011_gene3515	2.07e-143	459.0	COG1131@1|root,COG1131@2|Bacteria,1MY19@1224|Proteobacteria,2U2ZW@28211|Alphaproteobacteria,2KFDG@204458|Caulobacterales	204458|Caulobacterales	V	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
SHD2_k127_5337882_2	509190.Cseg_4052	0.0	1349.0	COG0308@1|root,COG1277@1|root,COG0308@2|Bacteria,COG1277@2|Bacteria,1PTWJ@1224|Proteobacteria,2U237@28211|Alphaproteobacteria,2KG1X@204458|Caulobacterales	204458|Caulobacterales	E	Peptidase family M1 domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1
SHD2_k127_5337882_64	388051.AUFE01000018_gene171	8.182e-22	104.0	COG1309@1|root,COG1309@2|Bacteria,1MYVX@1224|Proteobacteria,2W5CU@28216|Betaproteobacteria	28216|Betaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
SHD2_k127_5337882_71	1194972.MVAC_29103	6.569e-08	55.0	COG1262@1|root,COG1262@2|Bacteria,2GK9Q@201174|Actinobacteria,235K8@1762|Mycobacteriaceae	201174|Actinobacteria	S	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
SHD2_k127_5337882_72	477184.KYC_15197	3.716e-07	51.0	COG1262@1|root,COG1262@2|Bacteria,1MZ25@1224|Proteobacteria,2WF20@28216|Betaproteobacteria,3T8M4@506|Alcaligenaceae	28216|Betaproteobacteria	S	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
SHD2_k127_5337882_73	935557.ATYB01000014_gene2684	2.438e-06	49.0	COG1262@1|root,COG1262@2|Bacteria,1MZ25@1224|Proteobacteria,2TRJH@28211|Alphaproteobacteria,4BBK1@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
SHD2_k127_5337882_69	614083.AWQR01000011_gene2370	2.434e-13	72.0	COG1262@1|root,COG1262@2|Bacteria,1MZ25@1224|Proteobacteria,2VKZ2@28216|Betaproteobacteria,4AD3Q@80864|Comamonadaceae	28216|Betaproteobacteria	S	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
SHD2_k127_5337882_33	402881.Plav_1540	4.037e-108	357.0	COG0179@1|root,COG0179@2|Bacteria,1MUPF@1224|Proteobacteria,2TQQG@28211|Alphaproteobacteria,1JNV6@119043|Rhodobiaceae	28211|Alphaproteobacteria	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	DUF2437,FAA_hydrolase
SHD2_k127_5337882_62	1333998.M2A_2185	1.177e-32	128.0	COG2175@1|root,COG2175@2|Bacteria,1MV5K@1224|Proteobacteria,2TQTZ@28211|Alphaproteobacteria,4BQDS@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	Q	Taurine catabolism dioxygenase TauD, TfdA family	-	-	1.14.11.17	ko:K03119	ko00430,ko00920,map00430,map00920	-	R05320	RC01331	ko00000,ko00001,ko01000	-	-	-	TauD
SHD2_k127_5337882_59	1479238.JQMZ01000001_gene2027	7.752e-42	160.0	COG2175@1|root,COG2175@2|Bacteria,1MV5K@1224|Proteobacteria,2U38D@28211|Alphaproteobacteria,4412B@69657|Hyphomonadaceae	28211|Alphaproteobacteria	Q	Taurine catabolism dioxygenase TauD, TfdA family	-	-	1.14.11.17	ko:K03119	ko00430,ko00920,map00430,map00920	-	R05320	RC01331	ko00000,ko00001,ko01000	-	-	-	TauD
SHD2_k127_5337882_51	1121378.KB899779_gene1580	1.193e-63	227.0	COG0412@1|root,COG0412@2|Bacteria	2|Bacteria	Q	carboxymethylenebutenolidase activity	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
SHD2_k127_5337882_17	450851.PHZ_c0594	3.457e-167	534.0	COG2124@1|root,COG2124@2|Bacteria,1R76Q@1224|Proteobacteria,2U3G8@28211|Alphaproteobacteria,2KG8Z@204458|Caulobacterales	204458|Caulobacterales	C	cytochrome P450	-	-	-	-	-	-	-	-	-	-	-	-	p450
SHD2_k127_5337882_13	402881.Plav_3077	3.105e-190	599.0	28M2T@1|root,2ZAH6@2|Bacteria,1R6GW@1224|Proteobacteria,2U25T@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_5337882_7	402881.Plav_2206	5.825e-254	792.0	COG0318@1|root,COG0318@2|Bacteria,1MVJ1@1224|Proteobacteria,2TUQ9@28211|Alphaproteobacteria,1JQM7@119043|Rhodobiaceae	28211|Alphaproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.42	ko:K00666,ko:K18688	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
SHD2_k127_5337882_53	1121124.JNIX01000008_gene2526	1.411e-51	191.0	COG1609@1|root,COG1609@2|Bacteria,1MVUR@1224|Proteobacteria,2U0SC@28211|Alphaproteobacteria,2KFV3@204458|Caulobacterales	204458|Caulobacterales	K	periplasmic binding protein LacI transcriptional regulator	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
SHD2_k127_5337882_37	502025.Hoch_1254	8.618e-103	340.0	COG0412@1|root,COG0412@2|Bacteria,1PSEB@1224|Proteobacteria,4340G@68525|delta/epsilon subdivisions,2X4F0@28221|Deltaproteobacteria,2YYWA@29|Myxococcales	28221|Deltaproteobacteria	Q	Dienelactone hydrolase and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	DLH
SHD2_k127_5337882_68	880073.Calab_2310	3.959e-15	87.0	COG0726@1|root,COG0726@2|Bacteria,2NQ5B@2323|unclassified Bacteria	2|Bacteria	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
SHD2_k127_5337882_50	395965.Msil_3537	5.27e-65	230.0	COG2148@1|root,COG2148@2|Bacteria,1MV6W@1224|Proteobacteria,2TRZA@28211|Alphaproteobacteria,3NAK3@45404|Beijerinckiaceae	28211|Alphaproteobacteria	M	Bacterial sugar transferase	-	-	2.7.8.6	ko:K00996,ko:K03606	ko05111,map05111	-	-	-	ko00000,ko00001,ko01000,ko01005	-	-	-	Bac_transf,CoA_binding_3
SHD2_k127_5337882_46	713586.KB900536_gene865	4.789e-74	259.0	COG1922@1|root,COG1922@2|Bacteria,1N1HD@1224|Proteobacteria,1RP6P@1236|Gammaproteobacteria,1WYZH@135613|Chromatiales	135613|Chromatiales	M	Belongs to the glycosyltransferase 26 family	-	-	2.4.1.187	ko:K05946	ko05111,map05111	-	-	-	ko00000,ko00001,ko01000,ko01003	-	GT26	-	Glyco_tran_WecB
SHD2_k127_5337882_60	693986.MOC_3743	1.369e-38	160.0	COG2244@1|root,COG2244@2|Bacteria,1QYQF@1224|Proteobacteria,2TXVW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	polysaccharide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_5337882_48	1449076.JOOE01000002_gene1108	2.877e-68	243.0	COG1216@1|root,COG1216@2|Bacteria,1R59U@1224|Proteobacteria,2TV7K@28211|Alphaproteobacteria,2K237@204457|Sphingomonadales	204457|Sphingomonadales	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glycos_transf_2
SHD2_k127_5337882_55	1449076.JOOE01000002_gene1109	1.768e-48	190.0	COG3307@1|root,COG3307@2|Bacteria,1R5EX@1224|Proteobacteria,2TTQF@28211|Alphaproteobacteria,2K3IA@204457|Sphingomonadales	204457|Sphingomonadales	M	O-Antigen ligase	-	-	-	-	-	-	-	-	-	-	-	-	Wzy_C
SHD2_k127_5337882_42	713586.KB900536_gene866	2.7e-86	300.0	COG1216@1|root,COG1216@2|Bacteria,1MZSD@1224|Proteobacteria	1224|Proteobacteria	G	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
SHD2_k127_5337882_43	99598.Cal7507_2084	7.856e-86	302.0	COG3693@1|root,COG3693@2|Bacteria,1G30Y@1117|Cyanobacteria,1HJ5C@1161|Nostocales	1117|Cyanobacteria	G	PFAM Glycosyl hydrolase family 10	-	-	3.2.1.8	ko:K01181	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_hydro_10
SHD2_k127_5337882_29	1267534.KB906755_gene4109	5.044e-118	394.0	COG2072@1|root,COG2072@2|Bacteria,3Y2Z7@57723|Acidobacteria,2JIU2@204432|Acidobacteriia	204432|Acidobacteriia	P	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_3
SHD2_k127_5337882_58	1267534.KB906757_gene1049	5.899e-47	184.0	COG2232@1|root,COG2232@2|Bacteria,3Y4IS@57723|Acidobacteria,2JJAM@204432|Acidobacteriia	204432|Acidobacteriia	S	ATP-grasp domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_3
SHD2_k127_5337882_47	414684.RC1_4006	3.085e-71	267.0	COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,1MVI9@1224|Proteobacteria,2TT1Y@28211|Alphaproteobacteria,2JQ8F@204441|Rhodospirillales	204441|Rhodospirillales	DM	Chain length determinant protein	-	-	-	ko:K16554	ko05111,map05111	-	-	-	ko00000,ko00001,ko02000	8.A.3.1	-	-	AAA_31,CbiA,GNVR,Wzz
SHD2_k127_5337882_70	349102.Rsph17025_1039	3.096e-09	67.0	COG5342@1|root,COG5342@2|Bacteria,1NA8M@1224|Proteobacteria,2TSY3@28211|Alphaproteobacteria,1FC2F@1060|Rhodobacter	28211|Alphaproteobacteria	S	PFAM Invasion associated locus B	MA20_19790	-	-	-	-	-	-	-	-	-	-	-	IalB
SHD2_k127_5337882_65	1280946.HY29_18200	4.224e-20	98.0	COG5342@1|root,COG5342@2|Bacteria,1PZA4@1224|Proteobacteria,2UCZ6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Invasion associated locus B (IalB) protein	-	-	-	-	-	-	-	-	-	-	-	-	IalB
SHD2_k127_5337882_56	258594.RPA2487	7.688e-48	178.0	COG0586@1|root,COG0586@2|Bacteria,1R0F3@1224|Proteobacteria,2U088@28211|Alphaproteobacteria,3JR8I@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	SNARE associated Golgi protein	MA20_30625	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
SHD2_k127_5337882_30	1038858.AXBA01000015_gene2081	2.166e-117	396.0	COG0845@1|root,COG0845@2|Bacteria,1MW65@1224|Proteobacteria,2TSB6@28211|Alphaproteobacteria,3F0K2@335928|Xanthobacteraceae	28211|Alphaproteobacteria	M	HlyD family secretion protein	-	-	-	ko:K07799,ko:K18990	ko02020,map02020	M00648,M00720	-	-	ko00000,ko00001,ko00002,ko02000	2.A.6.2.30,8.A.1	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
SHD2_k127_5337882_0	1380394.JADL01000001_gene1963	0.0	1390.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,2JQ03@204441|Rhodospirillales	204441|Rhodospirillales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K07788	ko02020,map02020	M00648	-	-	ko00000,ko00001,ko00002,ko02000	2.A.6.2	-	-	ACR_tran
SHD2_k127_5337882_3	1380394.JADL01000001_gene1962	0.0	1313.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,2JRJG@204441|Rhodospirillales	204441|Rhodospirillales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K07789	ko02020,map02020	M00648	-	-	ko00000,ko00001,ko00002,ko02000	2.A.6.2	-	-	ACR_tran
SHD2_k127_5337882_49	1244869.H261_19998	6.334e-68	238.0	COG2853@1|root,COG2853@2|Bacteria,1MVX0@1224|Proteobacteria,2U7CZ@28211|Alphaproteobacteria,2JS21@204441|Rhodospirillales	204441|Rhodospirillales	M	MlaA lipoprotein	-	-	-	ko:K04754	-	-	-	-	ko00000	-	-	-	MlaA
SHD2_k127_5337882_40	864069.MicloDRAFT_00013820	2.251e-91	308.0	COG2041@1|root,COG2041@2|Bacteria,1MUW0@1224|Proteobacteria,2TS40@28211|Alphaproteobacteria,1JSRI@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Oxidoreductase molybdopterin binding	-	-	-	ko:K07147	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_molyb
SHD2_k127_5337882_38	1028801.RG1141_CH03110	2.279e-98	329.0	COG4117@1|root,COG4117@2|Bacteria,1MX97@1224|Proteobacteria,2U0ZF@28211|Alphaproteobacteria,4BBB6@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	cytochrome	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB
SHD2_k127_5337882_31	1429916.X566_07870	1.697e-114	375.0	COG0596@1|root,COG0596@2|Bacteria,1Q4C8@1224|Proteobacteria,2TTW5@28211|Alphaproteobacteria,3JTEC@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Serine aminopeptidase, S33	MA20_23630	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
SHD2_k127_5337882_35	450851.PHZ_c2590	6.796e-106	349.0	COG1028@1|root,COG1028@2|Bacteria,1MUPX@1224|Proteobacteria,2TT6C@28211|Alphaproteobacteria,2KFEA@204458|Caulobacterales	204458|Caulobacterales	IQ	short-chain dehydrogenase	-	-	1.1.1.51	ko:K05296	ko00140,ko00984,ko01100,ko01120,map00140,map00984,map01100,map01120	-	R01836,R01838,R02352,R02353,R03406,R03407,R09956,R09957	RC00127,RC00144	ko00000,ko00001,ko01000	-	-	-	adh_short_C2
SHD2_k127_5337882_15	450851.PHZ_c1001	5.624e-179	569.0	COG1680@1|root,COG1680@2|Bacteria,1MVPR@1224|Proteobacteria,2TRWZ@28211|Alphaproteobacteria,2KFVB@204458|Caulobacterales	204458|Caulobacterales	V	beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
SHD2_k127_5337882_16	172088.AUGA01000041_gene4847	2.971e-173	554.0	COG0477@1|root,COG0477@2|Bacteria,1MWUR@1224|Proteobacteria,2TT7N@28211|Alphaproteobacteria,3JQZB@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	ko:K08169	-	-	-	-	ko00000,ko02000	2.A.1.3.17	-	-	MFS_1
SHD2_k127_5337882_21	402881.Plav_1873	2.365e-155	500.0	COG1960@1|root,COG1960@2|Bacteria,1R7HF@1224|Proteobacteria,2U3BJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	COG1960 Acyl-CoA dehydrogenases	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_N
SHD2_k127_5337882_10	1282876.BAOK01000002_gene898	2.811e-204	642.0	COG1960@1|root,COG1960@2|Bacteria,1P8I7@1224|Proteobacteria,2U0AW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
SHD2_k127_5337882_12	288000.BBta_7123	1.155e-195	616.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TSA0@28211|Alphaproteobacteria,3JQM2@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Belongs to the thiolase family	MA20_06750	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
SHD2_k127_5337882_8	1380394.JADL01000008_gene3512	5.009e-209	664.0	COG3540@1|root,COG3540@2|Bacteria,1MWAF@1224|Proteobacteria,2TS7J@28211|Alphaproteobacteria,2JQWQ@204441|Rhodospirillales	204441|Rhodospirillales	P	PhoD-like phosphatase, N-terminal domain	-	-	3.1.3.1	ko:K01113	ko00790,ko01100,ko02020,map00790,map01100,map02020	M00126	R04620	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PhoD,PhoD_N
SHD2_k127_5337882_20	1205680.CAKO01000038_gene1740	6.281e-157	505.0	COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,2TW14@28211|Alphaproteobacteria,2JQB5@204441|Rhodospirillales	204441|Rhodospirillales	E	COG0626 Cystathionine beta-lyases cystathionine gamma-synthases	metB	-	2.5.1.48	ko:K01739	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00999,R01288,R02508,R03217,R03260,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00420,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
SHD2_k127_5337882_19	69395.JQLZ01000002_gene1453	6.529e-158	505.0	COG2070@1|root,COG2070@2|Bacteria,1MU0U@1224|Proteobacteria,2TS5U@28211|Alphaproteobacteria,2KFAG@204458|Caulobacterales	204458|Caulobacterales	S	2-nitropropane dioxygenase	-	-	1.13.12.16	ko:K00459	ko00910,map00910	-	R00025	RC02541,RC02759	ko00000,ko00001,ko01000	-	-	-	NMO
SHD2_k127_5337882_54	450851.PHZ_c0753	1.106e-48	187.0	COG1309@1|root,COG1309@2|Bacteria,1RHEM@1224|Proteobacteria,2UDIZ@28211|Alphaproteobacteria,2KIKR@204458|Caulobacterales	204458|Caulobacterales	K	WHG domain	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N,WHG
SHD2_k127_5337882_14	588932.JHOF01000018_gene745	2.064e-185	601.0	COG4206@1|root,COG4206@2|Bacteria,1R1WX@1224|Proteobacteria,2U0GK@28211|Alphaproteobacteria,2KFVP@204458|Caulobacterales	204458|Caulobacterales	H	TonB-dependent Receptor Plug	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
SHD2_k127_5337882_27	1161401.ASJA01000009_gene1729	7.526e-120	388.0	COG1788@1|root,COG1788@2|Bacteria,1MVEI@1224|Proteobacteria,2TTE6@28211|Alphaproteobacteria,43W92@69657|Hyphomonadaceae	28211|Alphaproteobacteria	I	COG1788 Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit	scoA	-	2.8.3.5	ko:K01028	ko00072,ko00280,ko00650,map00072,map00280,map00650	-	R00410	RC00014	ko00000,ko00001,ko01000	-	-	-	CoA_trans
SHD2_k127_5337882_36	384765.SIAM614_05341	2.397e-105	345.0	COG2057@1|root,COG2057@2|Bacteria,1RA4V@1224|Proteobacteria,2TQS5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	COG2057 Acyl CoA acetate 3-ketoacid CoA transferase, beta subunit	scoB	-	2.8.3.5	ko:K01029	ko00072,ko00280,ko00650,map00072,map00280,map00650	-	R00410	RC00014	ko00000,ko00001,ko01000	-	-	-	CoA_trans
SHD2_k127_5337882_57	1382303.JPOM01000001_gene235	1.206e-47	184.0	COG3735@1|root,COG3735@2|Bacteria,1N8WD@1224|Proteobacteria,2UG39@28211|Alphaproteobacteria,2KH5Z@204458|Caulobacterales	204458|Caulobacterales	S	PFAM GumN family protein	-	-	-	-	-	-	-	-	-	-	-	-	TraB
SHD2_k127_5337882_41	394221.Mmar10_2166	1.251e-88	302.0	COG1192@1|root,COG1192@2|Bacteria,1MWH3@1224|Proteobacteria,2U100@28211|Alphaproteobacteria,440T4@69657|Hyphomonadaceae	28211|Alphaproteobacteria	D	VirC1 protein	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31,CbiA
SHD2_k127_5337882_44	102129.Lepto7375DRAFT_7695	2.803e-85	292.0	COG0667@1|root,COG0667@2|Bacteria	2|Bacteria	C	Aldo Keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red,Fer4
SHD2_k127_5337882_5	69395.JQLZ01000002_gene1302	1.361e-256	797.0	COG3670@1|root,COG3670@2|Bacteria,1MY1X@1224|Proteobacteria,2TS7A@28211|Alphaproteobacteria,2KI00@204458|Caulobacterales	204458|Caulobacterales	Q	dioxygenase	-	-	-	ko:K11159	-	-	-	-	ko00000	-	-	-	RPE65
SHD2_k127_5337882_32	1449049.JONW01000008_gene354	2.723e-110	362.0	COG3752@1|root,COG3752@2|Bacteria,1MXCP@1224|Proteobacteria,2VG88@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1295)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1295
SHD2_k127_5337882_39	1244869.H261_19621	2.259e-97	325.0	COG1619@1|root,COG1619@2|Bacteria,1MWIY@1224|Proteobacteria,2U0U5@28211|Alphaproteobacteria,2JVNZ@204441|Rhodospirillales	204441|Rhodospirillales	V	proteins, homologs of microcin C7 resistance protein MccF	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S66
SHD2_k127_5337882_11	1316936.K678_07288	5.976e-198	626.0	COG0773@1|root,COG0773@2|Bacteria,1MVCG@1224|Proteobacteria,2TTDN@28211|Alphaproteobacteria,2JVB2@204441|Rhodospirillales	204441|Rhodospirillales	M	Mur ligase family, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
SHD2_k127_5337882_25	366602.Caul_0517	4.299e-136	449.0	COG2211@1|root,COG2211@2|Bacteria,1MVUM@1224|Proteobacteria,2U1DI@28211|Alphaproteobacteria,2KFG7@204458|Caulobacterales	204458|Caulobacterales	G	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_2
SHD2_k127_5337882_34	1210884.HG799468_gene13566	3.389e-107	354.0	COG4221@1|root,COG4221@2|Bacteria,2IYGT@203682|Planctomycetes	203682|Planctomycetes	S	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
SHD2_k127_5337882_66	1123366.TH3_15709	4.259e-18	89.0	COG2827@1|root,COG2827@2|Bacteria,1N2X6@1224|Proteobacteria,2UCV1@28211|Alphaproteobacteria,2JUMY@204441|Rhodospirillales	204441|Rhodospirillales	L	endonuclease containing a URI domain	-	-	-	ko:K07461	-	-	-	-	ko00000	-	-	-	GIY-YIG
SHD2_k127_5337882_26	1382303.JPOM01000001_gene421	2.853e-131	426.0	COG0042@1|root,COG0042@2|Bacteria,1MV5V@1224|Proteobacteria,2TRC8@28211|Alphaproteobacteria,2KFP5@204458|Caulobacterales	204458|Caulobacterales	H	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	-	-	-	-	-	-	-	-	-	-	-	-	Dus
SHD2_k127_5337882_61	596320.NEIFL0001_1527	8.873e-35	139.0	COG0545@1|root,COG0545@2|Bacteria,1RDA1@1224|Proteobacteria,2VSKZ@28216|Betaproteobacteria,2KQS6@206351|Neisseriales	206351|Neisseriales	M	Psort location OuterMembrane, score 9.92	fkpA	-	5.2.1.8	ko:K03772	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C,FKBP_N
SHD2_k127_5337882_6	114615.BRADO6356	7.434e-256	800.0	COG2509@1|root,COG2509@2|Bacteria,1MV6P@1224|Proteobacteria,2TSEQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	FAD dependent oxidoreductase	-	-	-	ko:K07137	-	-	-	-	ko00000	-	-	-	Amino_oxidase,FAD_binding_3,Pyr_redox_2
SHD2_k127_5337882_22	1449049.JONW01000002_gene2560	3.496e-148	480.0	COG2081@1|root,COG2081@2|Bacteria,1MUGC@1224|Proteobacteria,2TR1K@28211|Alphaproteobacteria,2KFY4@204458|Caulobacterales	204458|Caulobacterales	S	HI0933 family	-	-	-	ko:K07007	-	-	-	-	ko00000	-	-	-	HI0933_like
SHD2_k127_5337882_45	1267535.KB906767_gene1480	7.797e-81	276.0	COG2120@1|root,COG2120@2|Bacteria	2|Bacteria	S	N-acetylglucosaminylinositol deacetylase activity	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
SHD2_k127_5337882_28	1380394.JADL01000005_gene5586	2.472e-119	391.0	COG1262@1|root,COG1262@2|Bacteria,1NQ5K@1224|Proteobacteria,2U2VJ@28211|Alphaproteobacteria,2JS16@204441|Rhodospirillales	204441|Rhodospirillales	T	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,Peptidase_C14
SHD2_k127_5337882_9	1248916.ANFY01000003_gene611	1.11e-208	651.0	COG1960@1|root,COG1960@2|Bacteria,1MU2V@1224|Proteobacteria,2TSK3@28211|Alphaproteobacteria,2KCQC@204457|Sphingomonadales	204457|Sphingomonadales	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
SHD2_k127_5343854_20	1280950.HJO_02645	9.923e-36	136.0	COG0183@1|root,COG0183@2|Bacteria,1R5AW@1224|Proteobacteria,2U1UK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	acetyl-coa acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Thiolase_C,Thiolase_N
SHD2_k127_5343854_9	402881.Plav_2677	2.737e-116	379.0	COG5285@1|root,COG5285@2|Bacteria,1QRDD@1224|Proteobacteria,2U0EC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Protein involved in biosynthesis of mitomycin antibiotics polyketide fumonisin	-	-	-	-	-	-	-	-	-	-	-	-	PhyH
SHD2_k127_5343854_8	1333998.M2A_0706	9.217e-117	383.0	COG0667@1|root,COG0667@2|Bacteria,1R7AM@1224|Proteobacteria,2U0JN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
SHD2_k127_5343854_24	670307.HYPDE_31768	1.482e-09	61.0	2EFTF@1|root,339JI@2|Bacteria,1NIP0@1224|Proteobacteria	1224|Proteobacteria	S	Protein of unknown function (DUF2842)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2842
SHD2_k127_5343854_14	1297865.APJD01000007_gene1892	1.816e-95	320.0	COG2267@1|root,COG2267@2|Bacteria,1R4YR@1224|Proteobacteria,2VEYN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
SHD2_k127_5343854_4	251221.35213312	6.038e-152	501.0	COG0457@1|root,COG0457@2|Bacteria,1G31A@1117|Cyanobacteria	1117|Cyanobacteria	S	tetratricopeptide	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_8
SHD2_k127_5343854_13	402881.Plav_2927	1.435e-97	331.0	COG1612@1|root,COG1612@2|Bacteria,1MVJ4@1224|Proteobacteria,2TR0M@28211|Alphaproteobacteria,1JNCS@119043|Rhodobiaceae	28211|Alphaproteobacteria	O	Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group	ctaA	-	-	ko:K02259	ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714	M00154	R07412	RC00769	ko00000,ko00001,ko00002,ko03029	3.D.4.4	-	-	COX15-CtaA
SHD2_k127_5343854_2	395963.Bind_0812	1.32e-188	597.0	COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,2TQW9@28211|Alphaproteobacteria,3NA6G@45404|Beijerinckiaceae	28211|Alphaproteobacteria	E	Cys/Met metabolism PLP-dependent enzyme	metY	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003961,GO:0004124,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006555,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009070,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0017144,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0050667,GO:0071265,GO:0071266,GO:0071268,GO:0071269,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.5.1.47,2.5.1.49	ko:K01738,ko:K01740	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R01287,R03601,R04859	RC00020,RC02814,RC02821,RC02848	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
SHD2_k127_5343854_15	1297865.APJD01000036_gene1521	1.942e-86	290.0	COG0625@1|root,COG0625@2|Bacteria,1RA4M@1224|Proteobacteria,2TV0I@28211|Alphaproteobacteria,3JTZ7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Glutathione S-transferase, N-terminal domain	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_2,GST_N,GST_N_3
SHD2_k127_5343854_19	648757.Rvan_1710	2.21e-57	205.0	COG1832@1|root,COG1832@2|Bacteria,1N03D@1224|Proteobacteria,2TUIY@28211|Alphaproteobacteria,3N8VD@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	CoA binding domain	yccU	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
SHD2_k127_5343854_11	114615.BRADO4219	3.013e-100	334.0	COG1024@1|root,COG1024@2|Bacteria,1MUJ7@1224|Proteobacteria,2TTMB@28211|Alphaproteobacteria,3JRTP@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	enoyl-CoA hydratase	MA20_36945	-	-	-	-	-	-	-	-	-	-	-	ECH_1
SHD2_k127_5343854_17	652103.Rpdx1_2736	7.57e-72	246.0	COG0102@1|root,COG0102@2|Bacteria,1RA11@1224|Proteobacteria,2U5FM@28211|Alphaproteobacteria,3JUX1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
SHD2_k127_5343854_18	1437448.AZRT01000025_gene2687	6.84e-61	214.0	COG0103@1|root,COG0103@2|Bacteria,1RD4A@1224|Proteobacteria,2U5B5@28211|Alphaproteobacteria,1J26X@118882|Brucellaceae	28211|Alphaproteobacteria	J	structural constituent of ribosome	rpsI	GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
SHD2_k127_5343854_23	1179226.AJXO01000053_gene2868	5.04e-10	67.0	COG3152@1|root,COG3152@2|Bacteria,1UWH9@1239|Firmicutes,4HS9M@91061|Bacilli,4GZ8C@90964|Staphylococcaceae	91061|Bacilli	S	Protein of unknown function (DUF805)	-	-	-	-	-	-	-	-	-	-	-	-	DUF805
SHD2_k127_5343854_7	1040989.AWZU01000084_gene3851	2.874e-123	404.0	COG0002@1|root,COG0002@2|Bacteria,1MVJ6@1224|Proteobacteria,2TRMT@28211|Alphaproteobacteria,3JRRU@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	-	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh
SHD2_k127_5343854_21	279238.Saro_2838	3.686e-34	140.0	COG2808@1|root,COG2808@2|Bacteria,1N1B9@1224|Proteobacteria,2U5JV@28211|Alphaproteobacteria,2K2BS@204457|Sphingomonadales	204457|Sphingomonadales	K	Putative FMN-binding domain	-	-	-	ko:K07734	-	-	-	-	ko00000,ko03000	-	-	-	FMN_bind_2
SHD2_k127_5343854_0	1121861.KB899923_gene3458	1.36e-237	751.0	COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,2TR7S@28211|Alphaproteobacteria,2JQCH@204441|Rhodospirillales	204441|Rhodospirillales	I	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus	phbC	-	-	ko:K03821	ko00650,map00650	-	R04254	RC00004	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1,PhaC_N
SHD2_k127_5343854_22	1282876.BAOK01000001_gene1938	3.558e-26	123.0	COG2885@1|root,COG2885@2|Bacteria,1N2EI@1224|Proteobacteria,2UD4D@28211|Alphaproteobacteria,4BSXR@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	M	OmpA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
SHD2_k127_5343854_1	69395.JQLZ01000007_gene1635	3.749e-196	617.0	COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,2TRE3@28211|Alphaproteobacteria,2KFVH@204458|Caulobacterales	204458|Caulobacterales	E	Aminotransferase	-	-	-	ko:K14261	-	-	-	-	ko00000,ko01000,ko01007	-	-	-	Aminotran_1_2
SHD2_k127_5343854_6	1110502.TMO_1943	1.583e-132	437.0	COG0460@1|root,COG0460@2|Bacteria,1MUDC@1224|Proteobacteria,2TQWS@28211|Alphaproteobacteria,2JPAR@204441|Rhodospirillales	204441|Rhodospirillales	E	homoserine dehydrogenase	hom	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,Homoserine_dh,NAD_binding_3
SHD2_k127_5343854_5	1122137.AQXF01000006_gene759	5.977e-137	442.0	COG1494@1|root,COG1494@2|Bacteria,1MUB1@1224|Proteobacteria,2TSPE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Fructose-1,6-bisphosphatase	glpX	-	3.1.3.11,3.1.3.37	ko:K02446,ko:K11532	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00165,M00167	R00762,R01845,R04780	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_glpX
SHD2_k127_5343854_3	402881.Plav_2948	7.639e-170	552.0	COG0608@1|root,COG0608@2|Bacteria,1MU1M@1224|Proteobacteria,2TRZQ@28211|Alphaproteobacteria,1JN7S@119043|Rhodobiaceae	28211|Alphaproteobacteria	L	DHH family	recJ	GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008297,GO:0008409,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0033554,GO:0034641,GO:0035312,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0045145,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
SHD2_k127_5343854_10	1282876.BAOK01000001_gene1950	8.234e-107	351.0	COG0846@1|root,COG0846@2|Bacteria,1MUK1@1224|Proteobacteria,2TV1Q@28211|Alphaproteobacteria,4BR1I@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	K	Sir2 family	MA20_30275	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
SHD2_k127_5343854_16	59538.XP_005975964.1	9.11e-82	277.0	COG0740@1|root,KOG0840@2759|Eukaryota,38PE0@33154|Opisthokonta,3BEPT@33208|Metazoa,3CVZ0@33213|Bilateria,47ZUG@7711|Chordata,49730@7742|Vertebrata	33208|Metazoa	O	serine-type endopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	CLP_protease
SHD2_k127_5343854_12	43989.cce_2139	1.54e-98	334.0	COG0366@1|root,COG0366@2|Bacteria,1G2UN@1117|Cyanobacteria,3KJ7U@43988|Cyanothece	1117|Cyanobacteria	G	Maltogenic Amylase, C-terminal domain	-	-	3.2.1.1,3.2.1.20,5.4.99.16	ko:K01187,ko:K05343	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R01557,R02108,R02112,R06087,R06088,R11262	RC00028,RC00049,RC00077,RC01816	ko00000,ko00001,ko01000	-	GH13,GH31	-	Alpha-amylase,Malt_amylase_C
SHD2_k127_5352693_6	272943.RSP_1883	1.443e-82	291.0	COG0687@1|root,COG0687@2|Bacteria,1MU0I@1224|Proteobacteria,2TRJ3@28211|Alphaproteobacteria,1FBCH@1060|Rhodobacter	28211|Alphaproteobacteria	E	extracellular solute-binding protein	potD	-	-	ko:K02055	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	SBP_bac_8
SHD2_k127_5352693_4	414684.RC1_3364	1.431e-129	421.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TTN3@28211|Alphaproteobacteria,2JRET@204441|Rhodospirillales	204441|Rhodospirillales	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K15581	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1
SHD2_k127_5352693_5	1121935.AQXX01000140_gene1032	3.1e-128	416.0	COG1173@1|root,COG1173@2|Bacteria,1MU26@1224|Proteobacteria,1RND6@1236|Gammaproteobacteria,1XH9S@135619|Oceanospirillales	135619|Oceanospirillales	EP	N-terminal TM domain of oligopeptide transport permease C	-	-	-	ko:K02034,ko:K15582	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1,OppC_N
SHD2_k127_5352693_0	1122613.ATUP01000001_gene1085	3.429e-254	797.0	COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2TQP0@28211|Alphaproteobacteria,43X7Z@69657|Hyphomonadaceae	28211|Alphaproteobacteria	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
SHD2_k127_5352693_8	1268239.PALB_20720	3.246e-06	57.0	2C79Y@1|root,33267@2|Bacteria,1N7XV@1224|Proteobacteria,1SEFE@1236|Gammaproteobacteria,2Q2JY@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_5352693_1	1161401.ASJA01000005_gene2503	2.042e-155	508.0	COG4166@1|root,COG4166@2|Bacteria,1P91R@1224|Proteobacteria,2TT6P@28211|Alphaproteobacteria,43X0B@69657|Hyphomonadaceae	28211|Alphaproteobacteria	E	COG4166 ABC-type oligopeptide transport system, periplasmic component	oppA	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006457,GO:0006810,GO:0006857,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0015833,GO:0030288,GO:0030313,GO:0031975,GO:0033218,GO:0042277,GO:0042597,GO:0042886,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0061077,GO:0071702,GO:0071705,GO:1900750	-	ko:K02035,ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	SBP_bac_5
SHD2_k127_5352693_2	1161401.ASJA01000005_gene2503	1.202e-138	458.0	COG4166@1|root,COG4166@2|Bacteria,1P91R@1224|Proteobacteria,2TT6P@28211|Alphaproteobacteria,43X0B@69657|Hyphomonadaceae	28211|Alphaproteobacteria	E	COG4166 ABC-type oligopeptide transport system, periplasmic component	oppA	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006457,GO:0006810,GO:0006857,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0015833,GO:0030288,GO:0030313,GO:0031975,GO:0033218,GO:0042277,GO:0042597,GO:0042886,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0061077,GO:0071702,GO:0071705,GO:1900750	-	ko:K02035,ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	SBP_bac_5
SHD2_k127_5352693_3	1161401.ASJA01000005_gene2503	1.251e-136	452.0	COG4166@1|root,COG4166@2|Bacteria,1P91R@1224|Proteobacteria,2TT6P@28211|Alphaproteobacteria,43X0B@69657|Hyphomonadaceae	28211|Alphaproteobacteria	E	COG4166 ABC-type oligopeptide transport system, periplasmic component	oppA	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006457,GO:0006810,GO:0006857,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0015833,GO:0030288,GO:0030313,GO:0031975,GO:0033218,GO:0042277,GO:0042597,GO:0042886,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0061077,GO:0071702,GO:0071705,GO:1900750	-	ko:K02035,ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	SBP_bac_5
SHD2_k127_5352693_7	1123240.ATVO01000009_gene715	1.896e-10	66.0	2EQ70@1|root,33HT9@2|Bacteria,1NIHT@1224|Proteobacteria,2UK3J@28211|Alphaproteobacteria,2K5XI@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_5387423_50	1333998.M2A_1102	4.477e-98	326.0	COG1024@1|root,COG1024@2|Bacteria,1MVQN@1224|Proteobacteria,2TUXD@28211|Alphaproteobacteria,4BS0J@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	I	Enoyl-CoA hydratase/isomerase	MA20_16380	-	5.3.3.18	ko:K15866	ko00360,ko01120,map00360,map01120	-	R09837,R09839	RC00004,RC00326,RC02689,RC03003	ko00000,ko00001,ko01000	-	-	-	ECH_1
SHD2_k127_5387423_12	1382303.JPOM01000001_gene305	2.013e-198	640.0	COG3590@1|root,COG3590@2|Bacteria,1MVNQ@1224|Proteobacteria,2TRU4@28211|Alphaproteobacteria,2KEYS@204458|Caulobacterales	204458|Caulobacterales	O	peptidase M13	-	-	-	ko:K07386	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M13,Peptidase_M13_N
SHD2_k127_5387423_9	1382303.JPOM01000001_gene305	9.093e-223	710.0	COG3590@1|root,COG3590@2|Bacteria,1MVNQ@1224|Proteobacteria,2TRU4@28211|Alphaproteobacteria,2KEYS@204458|Caulobacterales	204458|Caulobacterales	O	peptidase M13	-	-	-	ko:K07386	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M13,Peptidase_M13_N
SHD2_k127_5387423_105	883078.HMPREF9695_01697	1.176e-17	87.0	COG3070@1|root,COG3070@2|Bacteria,1N8X8@1224|Proteobacteria,2UFNC@28211|Alphaproteobacteria,3JYWH@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	TfoX N-terminal domain	MA20_30690	-	-	ko:K07343	-	-	-	-	ko00000	-	-	-	TfoX_N
SHD2_k127_5387423_109	1048339.KB913029_gene494	3.489e-13	76.0	COG0789@1|root,COG0789@2|Bacteria,2IQGQ@201174|Actinobacteria,4EW8J@85013|Frankiales	201174|Actinobacteria	K	Transcription regulator MerR, DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
SHD2_k127_5387423_102	1384054.N790_02950	3.372e-24	108.0	COG5485@1|root,COG5485@2|Bacteria,1RDG8@1224|Proteobacteria,1S4CM@1236|Gammaproteobacteria,1X71J@135614|Xanthomonadales	135614|Xanthomonadales	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL
SHD2_k127_5387423_84	438753.AZC_3609	6.823e-48	175.0	COG0316@1|root,COG0316@2|Bacteria,1RH6T@1224|Proteobacteria,2UBWJ@28211|Alphaproteobacteria,3EZMX@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	Belongs to the HesB IscA family	iscA	GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0009058,GO:0009987,GO:0010467,GO:0016043,GO:0016226,GO:0018130,GO:0019438,GO:0019538,GO:0022607,GO:0031163,GO:0031974,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051537,GO:0051540,GO:0051604,GO:0070013,GO:0071704,GO:0071840,GO:0097428,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	-	ko:K13628	-	-	-	-	ko00000,ko03016	-	-	-	Fe-S_biosyn
SHD2_k127_5387423_89	1333998.M2A_1105	1.052e-45	169.0	COG2151@1|root,COG2151@2|Bacteria,1MZ9Y@1224|Proteobacteria,2U72U@28211|Alphaproteobacteria,4BQRU@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Iron-sulfur cluster assembly protein	MA20_30700	-	-	-	-	-	-	-	-	-	-	-	FeS_assembly_P
SHD2_k127_5387423_85	945713.IALB_2897	1.536e-47	174.0	COG0822@1|root,COG0822@2|Bacteria	2|Bacteria	C	iron-sulfur transferase activity	nifU	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0008150,GO:0008152,GO:0008198,GO:0009987,GO:0010467,GO:0016740,GO:0016782,GO:0019538,GO:0019725,GO:0030003,GO:0036455,GO:0042592,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0046916,GO:0048037,GO:0048878,GO:0050801,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0051604,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0071704,GO:0097428,GO:0098771,GO:1901564	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
SHD2_k127_5387423_19	1192868.CAIU01000024_gene3494	1.819e-171	550.0	COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,2TRNY@28211|Alphaproteobacteria,43GSX@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	sufS	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
SHD2_k127_5387423_76	414684.RC1_0491	3.512e-60	223.0	COG0719@1|root,COG0719@2|Bacteria,1MVK0@1224|Proteobacteria,2TTK9@28211|Alphaproteobacteria,2JPFV@204441|Rhodospirillales	204441|Rhodospirillales	O	Uncharacterized protein family (UPF0051)	sufD	-	-	ko:K09015	-	-	-	-	ko00000	-	-	-	UPF0051
SHD2_k127_5387423_42	1333998.M2A_1108	1.805e-110	367.0	COG0396@1|root,COG0396@2|Bacteria,1MUGK@1224|Proteobacteria,2TS8T@28211|Alphaproteobacteria,4BP5R@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	O	TIGRFAM FeS assembly ATPase SufC	sufC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0044085,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051186,GO:0071840	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
SHD2_k127_5387423_4	402881.Plav_3262	5.245e-256	796.0	COG0719@1|root,COG0719@2|Bacteria,1MVKY@1224|Proteobacteria,2TRU6@28211|Alphaproteobacteria,1JN71@119043|Rhodobiaceae	28211|Alphaproteobacteria	O	Uncharacterized protein family (UPF0051)	sufB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009536,GO:0009842,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464	-	ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
SHD2_k127_5387423_52	1411123.JQNH01000001_gene1044	6.229e-98	336.0	COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,2TSQE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	nifS	GO:0000096,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006464,GO:0006520,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016043,GO:0016226,GO:0016740,GO:0016782,GO:0016783,GO:0018130,GO:0018282,GO:0018283,GO:0019538,GO:0019637,GO:0019693,GO:0019752,GO:0022607,GO:0031071,GO:0031163,GO:0031974,GO:0031981,GO:0032324,GO:0034641,GO:0036211,GO:0042278,GO:0042802,GO:0042803,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043436,GO:0043545,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0046983,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0065003,GO:0070013,GO:0071704,GO:0071840,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
SHD2_k127_5387423_78	1244869.H261_15582	9.341e-59	209.0	COG1959@1|root,COG1959@2|Bacteria,1RDA4@1224|Proteobacteria,2U5B9@28211|Alphaproteobacteria,2JRRT@204441|Rhodospirillales	204441|Rhodospirillales	K	transcriptional regulator	iscR	-	-	ko:K13643	-	-	-	-	ko00000,ko03000	-	-	-	Rrf2
SHD2_k127_5387423_55	412597.AEPN01000031_gene524	2.508e-87	294.0	COG2945@1|root,COG2945@2|Bacteria,1MUDY@1224|Proteobacteria,2TRMI@28211|Alphaproteobacteria,2PV3G@265|Paracoccus	28211|Alphaproteobacteria	S	X-Pro dipeptidyl-peptidase (S15 family)	QU41_16170	-	-	ko:K07018	-	-	-	-	ko00000	-	-	-	Hydrolase_4,Peptidase_S15
SHD2_k127_5387423_34	402881.Plav_3266	2.643e-128	420.0	COG2377@1|root,COG2377@2|Bacteria,1MV4E@1224|Proteobacteria,2TS4G@28211|Alphaproteobacteria,1JN37@119043|Rhodobiaceae	28211|Alphaproteobacteria	O	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling	anmK	-	2.7.1.170	ko:K09001	-	-	-	-	ko00000,ko01000	-	-	-	AnmK
SHD2_k127_5387423_20	1298858.AUEL01000004_gene935	5.38e-167	540.0	COG0162@1|root,COG0162@2|Bacteria,1MVUQ@1224|Proteobacteria,2TQPA@28211|Alphaproteobacteria,43HII@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
SHD2_k127_5387423_45	402881.Plav_3269	3.682e-106	384.0	COG3164@1|root,COG3164@2|Bacteria,1MVDY@1224|Proteobacteria,2TSGG@28211|Alphaproteobacteria,1JN31@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function	MA20_30770	-	-	-	-	-	-	-	-	-	-	-	AsmA_2,DUF3971
SHD2_k127_5387423_73	1121033.AUCF01000005_gene5127	3.043e-62	218.0	COG1225@1|root,COG1225@2|Bacteria,1RD4R@1224|Proteobacteria,2U6Z9@28211|Alphaproteobacteria,2JS6P@204441|Rhodospirillales	204441|Rhodospirillales	O	Redoxin	bcp	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
SHD2_k127_5387423_59	402881.Plav_3272	1.543e-80	288.0	COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,2TQZE@28211|Alphaproteobacteria,1JP0R@119043|Rhodobiaceae	28211|Alphaproteobacteria	M	Peptidase family M23	MA20_30780	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
SHD2_k127_5387423_91	1333998.M2A_1122	4.655e-42	162.0	COG1664@1|root,COG1664@2|Bacteria,1MZN0@1224|Proteobacteria,2U5DW@28211|Alphaproteobacteria,4BR0P@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
SHD2_k127_5387423_28	754035.Mesau_04301	1.442e-150	483.0	COG1186@1|root,COG1186@2|Bacteria,1MUAW@1224|Proteobacteria,2TR9V@28211|Alphaproteobacteria,43ISZ@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
SHD2_k127_5387423_2	1207063.P24_14629	3.865e-273	862.0	COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,2USBB@28211|Alphaproteobacteria,2JQFN@204441|Rhodospirillales	204441|Rhodospirillales	M	penicillin-binding protein 1A	mrcA	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	PCB_OB,Transgly,Transpeptidase
SHD2_k127_5387423_49	1333998.M2A_1127	1.314e-99	341.0	COG0860@1|root,COG0860@2|Bacteria,1MUQK@1224|Proteobacteria,2U0K2@28211|Alphaproteobacteria,4BQ94@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	M	Ami_3	amiC	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	AMIN,Amidase_3
SHD2_k127_5387423_14	745310.G432_18105	3.992e-194	642.0	COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,2TS4W@28211|Alphaproteobacteria,2KEEP@204457|Sphingomonadales	204457|Sphingomonadales	P	COG1629 Outer membrane receptor proteins, mostly Fe transport	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
SHD2_k127_5387423_11	316055.RPE_2979	1.418e-200	659.0	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,2TRX2@28211|Alphaproteobacteria,3JSGG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	J	Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs	rne	-	3.1.26.12	ko:K08300	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
SHD2_k127_5387423_64	1333998.M2A_1130	1.398e-73	265.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2TR49@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	gamma-glutamyltransferase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
SHD2_k127_5387423_44	1333998.M2A_1131	5.11e-109	369.0	COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,2TTV2@28211|Alphaproteobacteria,4BP61@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Peptidase family M48	MA20_29180	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48,TPR_16,TPR_19
SHD2_k127_5387423_96	1297569.MESS2_730258	2.725e-33	139.0	COG1651@1|root,COG1651@2|Bacteria,1MY3H@1224|Proteobacteria,2TTXR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Dsba oxidoreductase	dsbA	-	-	-	-	-	-	-	-	-	-	-	DSBA,Thioredoxin_4
SHD2_k127_5387423_31	1545915.JROG01000008_gene3436	1.288e-141	456.0	COG2022@1|root,COG2022@2|Bacteria,1N0N5@1224|Proteobacteria,2TSXS@28211|Alphaproteobacteria,2K0MM@204457|Sphingomonadales	204457|Sphingomonadales	H	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S	thiG	-	2.8.1.10	ko:K03149	ko00730,ko01100,map00730,map01100	-	R10247	RC03096,RC03097,RC03461	ko00000,ko00001,ko01000	-	-	-	ThiG,ThiS
SHD2_k127_5387423_81	1282362.AEAC466_08390	6.387e-52	190.0	COG0757@1|root,COG0757@2|Bacteria,1RDDT@1224|Proteobacteria,2U9BV@28211|Alphaproteobacteria,2KGTR@204458|Caulobacterales	204458|Caulobacterales	E	Catalyzes a trans-dehydration via an enolate intermediate	aroQ	-	4.2.1.10	ko:K03786	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_II
SHD2_k127_5387423_93	1121033.AUCF01000001_gene2399	9.202e-37	148.0	COG0511@1|root,COG0511@2|Bacteria,1RCXA@1224|Proteobacteria,2U93Y@28211|Alphaproteobacteria,2JSTA@204441|Rhodospirillales	204441|Rhodospirillales	I	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA	accB	-	-	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742	RC00040,RC00367	ko00000,ko00001,ko00002	-	-	-	Biotin_lipoyl
SHD2_k127_5387423_7	402881.Plav_3292	1.684e-223	703.0	COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,2U25Z@28211|Alphaproteobacteria,1JN73@119043|Rhodobiaceae	28211|Alphaproteobacteria	I	Biotin carboxylase C-terminal domain	accC	GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
SHD2_k127_5387423_8	1238182.C882_2253	3.08e-223	702.0	COG4303@1|root,COG4303@2|Bacteria,1MUR4@1224|Proteobacteria,2TTNA@28211|Alphaproteobacteria,2JPSE@204441|Rhodospirillales	204441|Rhodospirillales	E	Ethanolamine ammonia-lyase large subunit	eutB	-	4.3.1.7	ko:K03735	ko00564,ko01100,map00564,map01100	-	R00749	RC00370	ko00000,ko00001,ko01000	-	-	-	EutB
SHD2_k127_5387423_68	1054213.HMPREF9946_02091	1.543e-67	238.0	COG4302@1|root,COG4302@2|Bacteria,1MWQI@1224|Proteobacteria,2U5EU@28211|Alphaproteobacteria,2JRPJ@204441|Rhodospirillales	204441|Rhodospirillales	E	Belongs to the EutC family	eutC	-	4.3.1.7	ko:K03736	ko00564,ko01100,map00564,map01100	-	R00749	RC00370	ko00000,ko00001,ko01000	-	-	-	EutC
SHD2_k127_5387423_94	1121106.JQKB01000066_gene5190	3.884e-35	139.0	COG2259@1|root,COG2259@2|Bacteria,1N072@1224|Proteobacteria,2UCXT@28211|Alphaproteobacteria,2JTGQ@204441|Rhodospirillales	204441|Rhodospirillales	S	DoxX	-	-	-	ko:K15977	-	-	-	-	ko00000	-	-	-	DoxX
SHD2_k127_5387423_62	1502851.FG93_02781	8.38e-78	267.0	COG2360@1|root,COG2360@2|Bacteria,1R9W8@1224|Proteobacteria,2U59K@28211|Alphaproteobacteria,3JUI9@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine	aat	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008914,GO:0016740,GO:0016746,GO:0016755,GO:0044424,GO:0044464,GO:0140096	2.3.2.6	ko:K00684	-	-	R03813,R11443,R11444	RC00055,RC00064	ko00000,ko01000	-	-	-	Leu_Phe_trans
SHD2_k127_5387423_101	441620.Mpop_1034	1.367e-25	113.0	COG4765@1|root,COG4765@2|Bacteria,1RHI7@1224|Proteobacteria,2UBR9@28211|Alphaproteobacteria,1JSXM@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2155)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2155
SHD2_k127_5387423_92	1282876.BAOK01000001_gene2361	9.791e-39	151.0	COG1463@1|root,COG1463@2|Bacteria,1NCUG@1224|Proteobacteria,2UCHU@28211|Alphaproteobacteria,4BQI6@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	Q	MlaD protein	mlaD	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
SHD2_k127_5387423_83	450851.PHZ_c1854	2.212e-48	176.0	COG3761@1|root,COG3761@2|Bacteria,1RHS3@1224|Proteobacteria,2U95G@28211|Alphaproteobacteria,2KGNZ@204458|Caulobacterales	204458|Caulobacterales	C	NADH ubiquinone oxidoreductase 17.2 kD subunit	-	-	-	-	-	-	-	-	-	-	-	-	NDUFA12
SHD2_k127_5387423_0	1038860.AXAP01000015_gene1948	0.0	1672.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2TS2I@28211|Alphaproteobacteria,3JSVM@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdJ	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_2_N,Ribonuc_red_lgC
SHD2_k127_5387423_90	1123257.AUFV01000010_gene3322	5.811e-44	164.0	2CVTP@1|root,32SY9@2|Bacteria,1N209@1224|Proteobacteria,1S8YX@1236|Gammaproteobacteria,1X7EG@135614|Xanthomonadales	135614|Xanthomonadales	S	Protein of unknown function (DUF1203)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1203
SHD2_k127_5387423_106	394221.Mmar10_1260	1.21e-16	88.0	COG1357@1|root,COG1357@2|Bacteria,1RIV8@1224|Proteobacteria,2UAGS@28211|Alphaproteobacteria,43Y0C@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	Pentapeptide repeats (9 copies)	-	-	-	-	-	-	-	-	-	-	-	-	Pentapeptide,Pentapeptide_4
SHD2_k127_5387423_77	378806.STAUR_6136	9.171e-59	209.0	COG3791@1|root,COG3791@2|Bacteria,1N031@1224|Proteobacteria,433ED@68525|delta/epsilon subdivisions,2WY6I@28221|Deltaproteobacteria,2Z0HK@29|Myxococcales	28221|Deltaproteobacteria	S	Glutathione-dependent formaldehyde-activating enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GFA
SHD2_k127_5387423_5	1333998.M2A_1534	3.907e-248	783.0	COG1003@1|root,COG1003@2|Bacteria,1MUDP@1224|Proteobacteria,2TSFF@28211|Alphaproteobacteria,4BPWY@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvP	-	1.4.4.2	ko:K00281,ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	Aminotran_5,GDC-P
SHD2_k127_5387423_15	1336243.JAEA01000003_gene2277	1.413e-191	606.0	COG0403@1|root,COG0403@2|Bacteria,1MVC1@1224|Proteobacteria,2TR6C@28211|Alphaproteobacteria,1JZ67@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	Glycine cleavage system P-protein	gcvPA	-	1.4.4.2	ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
SHD2_k127_5387423_88	570952.ATVH01000017_gene1678	3.431e-46	169.0	COG0509@1|root,COG0509@2|Bacteria,1RGV7@1224|Proteobacteria,2U9BY@28211|Alphaproteobacteria,2JSV1@204441|Rhodospirillales	204441|Rhodospirillales	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
SHD2_k127_5387423_35	1038858.AXBA01000013_gene2353	2.864e-127	419.0	COG0404@1|root,COG0404@2|Bacteria,1MV96@1224|Proteobacteria,2TRN4@28211|Alphaproteobacteria,3F0HP@335928|Xanthobacteraceae	28211|Alphaproteobacteria	E	Glycine cleavage T-protein C-terminal barrel domain	gcvT	GO:0001505,GO:0003674,GO:0003824,GO:0004047,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005960,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008483,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016740,GO:0016741,GO:0016769,GO:0017144,GO:0019464,GO:0019752,GO:0032259,GO:0032991,GO:0042133,GO:0042135,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1902494,GO:1990204	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
SHD2_k127_5387423_10	1380391.JIAS01000011_gene5214	5.378e-209	670.0	COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,2TS3Y@28211|Alphaproteobacteria,2JQHX@204441|Rhodospirillales	204441|Rhodospirillales	J	Arginyl-tRNA synthetase	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
SHD2_k127_5387423_108	629773.AORY01000004_gene361	7.636e-14	78.0	2B5IK@1|root,31YDD@2|Bacteria,1RAZF@1224|Proteobacteria,2U6F0@28211|Alphaproteobacteria,2K43H@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_5387423_98	1288298.rosmuc_02583	1.824e-30	124.0	COG3369@1|root,COG3369@2|Bacteria,1N6QZ@1224|Proteobacteria,2UGR1@28211|Alphaproteobacteria,46S02@74030|Roseovarius	28211|Alphaproteobacteria	S	CDGSH-type zinc finger. Function unknown.	-	-	-	-	-	-	-	-	-	-	-	-	zf-CDGSH
SHD2_k127_5387423_36	402881.Plav_0685	6.047e-122	399.0	COG2334@1|root,COG2334@2|Bacteria,1MUKJ@1224|Proteobacteria,2TS6D@28211|Alphaproteobacteria,1JNJ1@119043|Rhodobiaceae	28211|Alphaproteobacteria	F	Phosphotransferase enzyme family	thrB	-	2.7.1.39	ko:K02204	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	APH
SHD2_k127_5387423_74	1287276.X752_11895	1.546e-61	216.0	COG0328@1|root,COG0328@2|Bacteria,1RCZ1@1224|Proteobacteria,2U7C4@28211|Alphaproteobacteria,43JMW@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhA	-	3.1.26.4	ko:K03469	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_H
SHD2_k127_5387423_71	1380394.JADL01000002_gene1254	2.855e-66	236.0	COG0678@1|root,COG0678@2|Bacteria,1MU0H@1224|Proteobacteria,2U6ZN@28211|Alphaproteobacteria,2JSEH@204441|Rhodospirillales	204441|Rhodospirillales	O	Redoxin	-	-	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	Redoxin
SHD2_k127_5387423_75	391613.RTM1035_09523	9.994e-61	215.0	COG1678@1|root,COG1678@2|Bacteria,1RCXM@1224|Proteobacteria,2TTX4@28211|Alphaproteobacteria,46PVH@74030|Roseovarius	28211|Alphaproteobacteria	K	Belongs to the UPF0301 (AlgH) family	MA20_18155	-	-	ko:K07735	-	-	-	-	ko00000,ko03000	-	-	-	DUF179
SHD2_k127_5387423_41	1282876.BAOK01000001_gene2915	3.141e-116	409.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,4BRJ1@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	T	Putative diguanylate phosphodiesterase	MA20_18100	-	3.1.4.52	ko:K13245	ko04112,map04112	-	R08991	RC00296	ko00000,ko00001,ko01000	-	-	-	7TMR-DISMED2,7TMR-DISM_7TM,EAL,GGDEF,PAS_3
SHD2_k127_5387423_65	402881.Plav_0679	1.513e-73	256.0	COG1670@1|root,COG1670@2|Bacteria,1MVG4@1224|Proteobacteria,2TUIK@28211|Alphaproteobacteria,1JNUD@119043|Rhodobiaceae	28211|Alphaproteobacteria	J	Acetyltransferase (GNAT) domain	rimJ	-	2.3.1.128	ko:K03790	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_3
SHD2_k127_5387423_32	1333998.M2A_1521	5.52e-135	443.0	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,2TR39@28211|Alphaproteobacteria,4BPB1@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Belongs to the peptidase M16 family	mpp	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
SHD2_k127_5387423_30	1535287.JP74_06120	9.846e-143	471.0	COG0498@1|root,COG0498@2|Bacteria,1MUWQ@1224|Proteobacteria,2TT0D@28211|Alphaproteobacteria,3N6DM@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Threonine synthase	thrC	GO:0003674,GO:0003824,GO:0004795,GO:0006082,GO:0006520,GO:0006566,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016053,GO:0016311,GO:0016829,GO:0016835,GO:0016838,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP,Thr_synth_N
SHD2_k127_5387423_82	639283.Snov_0591	2.049e-49	184.0	COG3346@1|root,COG3346@2|Bacteria,1MWWG@1224|Proteobacteria,2U0N5@28211|Alphaproteobacteria,3EZAY@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	SURF1 family	surf1	-	-	ko:K14998	-	-	-	-	ko00000,ko03029	3.D.4.8	-	-	SURF1
SHD2_k127_5387423_95	411684.HPDFL43_03501	1.504e-34	135.0	COG5349@1|root,COG5349@2|Bacteria,1N0WU@1224|Proteobacteria,2UCE7@28211|Alphaproteobacteria,43K0S@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF983)	-	-	-	-	-	-	-	-	-	-	-	-	DUF983
SHD2_k127_5387423_38	114615.BRADO6702	1.928e-120	393.0	COG1845@1|root,COG1845@2|Bacteria,1MUCK@1224|Proteobacteria,2TQWA@28211|Alphaproteobacteria,3JV28@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	cytochrome c oxidase subunit III	ctaE	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
SHD2_k127_5387423_112	318996.AXAZ01000031_gene3329	6.95e-05	46.0	2EGEY@1|root,33A6Y@2|Bacteria,1N80G@1224|Proteobacteria,2UFIT@28211|Alphaproteobacteria,3K0X9@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	coxF	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_5387423_47	631454.N177_2261	2.107e-102	343.0	COG0109@1|root,COG0109@2|Bacteria,1MW3S@1224|Proteobacteria,2TRD8@28211|Alphaproteobacteria,1JNNQ@119043|Rhodobiaceae	28211|Alphaproteobacteria	O	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	ctaB	GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
SHD2_k127_5387423_1	1380355.JNIJ01000010_gene1522	3.828e-298	920.0	COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,2TQP1@28211|Alphaproteobacteria,3JTJ5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	ctaD	GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0022900,GO:0022904,GO:0034220,GO:0044237,GO:0044464,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
SHD2_k127_5387423_54	1429916.X566_05905	2.525e-93	317.0	COG1622@1|root,COG1622@2|Bacteria,1MWHZ@1224|Proteobacteria,2TRK6@28211|Alphaproteobacteria,3JTG1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	coxB	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM
SHD2_k127_5387423_6	402881.Plav_0666	3.368e-234	732.0	COG0312@1|root,COG0312@2|Bacteria,1MUSK@1224|Proteobacteria,2TRSR@28211|Alphaproteobacteria,1JNDP@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Putative modulator of DNA gyrase	tldD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
SHD2_k127_5387423_100	258594.RPA0796	3.365e-26	120.0	COG3502@1|root,COG3502@2|Bacteria,1MZEQ@1224|Proteobacteria,2UBR3@28211|Alphaproteobacteria,3JZ4V@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF952)	MA20_22095	-	-	-	-	-	-	-	-	-	-	-	DUF952
SHD2_k127_5387423_80	485913.Krac_3168	3.447e-58	215.0	COG3173@1|root,COG3173@2|Bacteria	2|Bacteria	S	very-long-chain-acyl-CoA dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	APH
SHD2_k127_5387423_67	224911.27349417	3.33e-70	244.0	COG3575@1|root,COG3575@2|Bacteria,1R5GH@1224|Proteobacteria,2U1BS@28211|Alphaproteobacteria,3JS3C@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Nucleotidyltransferase	-	-	-	ko:K09962	-	-	-	-	ko00000	-	-	-	NTP_transf_6
SHD2_k127_5387423_46	1380394.JADL01000001_gene2518	1.077e-104	347.0	COG1741@1|root,COG1741@2|Bacteria,1MWIP@1224|Proteobacteria,2TRHR@28211|Alphaproteobacteria,2JRBN@204441|Rhodospirillales	204441|Rhodospirillales	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
SHD2_k127_5387423_24	1192034.CAP_0832	4.945e-161	512.0	COG0667@1|root,COG0667@2|Bacteria,1MV2Y@1224|Proteobacteria,42MVI@68525|delta/epsilon subdivisions,2WPP7@28221|Deltaproteobacteria,2YUMH@29|Myxococcales	28221|Deltaproteobacteria	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
SHD2_k127_5387423_111	652103.Rpdx1_3031	3.363e-11	68.0	2C7HC@1|root,2ZEX5@2|Bacteria,1N7NS@1224|Proteobacteria,2UGBA@28211|Alphaproteobacteria,3K173@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_5387423_16	52598.EE36_04258	2.558e-187	595.0	COG3572@1|root,COG3572@2|Bacteria,1MU47@1224|Proteobacteria,2TRPT@28211|Alphaproteobacteria,3ZUZR@60136|Sulfitobacter	28211|Alphaproteobacteria	H	Glutamate-cysteine ligase family 2(GCS2)	gshA	-	6.3.2.2	ko:K01919	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00894,R10993	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	GCS2
SHD2_k127_5387423_99	402881.Plav_2671	1.1e-26	111.0	COG0640@1|root,COG0640@2|Bacteria,1N7VH@1224|Proteobacteria,2UFSW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
SHD2_k127_5387423_107	700508.D174_14195	3.651e-15	87.0	COG3832@1|root,COG3832@2|Bacteria,2HPW9@201174|Actinobacteria,236MN@1762|Mycobacteriaceae	201174|Actinobacteria	S	Activator of Hsp90 ATPase homolog 1-like	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
SHD2_k127_5387423_86	1205680.CAKO01000002_gene3102	2.161e-47	183.0	COG3832@1|root,COG3832@2|Bacteria,1REB4@1224|Proteobacteria,2U96I@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
SHD2_k127_5387423_60	1121033.AUCF01000019_gene3712	2.187e-79	278.0	COG1385@1|root,COG1385@2|Bacteria,1MXCU@1224|Proteobacteria,2TS0N@28211|Alphaproteobacteria,2JRPI@204441|Rhodospirillales	204441|Rhodospirillales	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	rsmE	-	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
SHD2_k127_5387423_48	1122218.KB893654_gene2235	4.726e-100	335.0	COG0382@1|root,COG0382@2|Bacteria,1MV4Q@1224|Proteobacteria,2TT3I@28211|Alphaproteobacteria,1JSUI@119045|Methylobacteriaceae	28211|Alphaproteobacteria	H	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate	ubiA	-	2.5.1.39	ko:K03179,ko:K06125	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117,M00128	R05000,R05615,R05616,R07273	RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
SHD2_k127_5387423_43	1333998.M2A_1504	2.333e-109	362.0	COG3239@1|root,COG3239@2|Bacteria,1MUHK@1224|Proteobacteria,2TSTR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Fatty acid desaturase	MA20_28095	-	-	-	-	-	-	-	-	-	-	-	FA_desaturase
SHD2_k127_5387423_39	1297865.APJD01000003_gene6065	4.602e-119	392.0	COG1162@1|root,COG1162@2|Bacteria,1MUEF@1224|Proteobacteria,2TR5R@28211|Alphaproteobacteria,3K3ZY@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	RsgA GTPase	rsgA	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	RsgA_GTPase
SHD2_k127_5387423_61	1168059.KB899087_gene116	3.62e-79	269.0	COG3897@1|root,COG3897@2|Bacteria,1N9VC@1224|Proteobacteria,2TV6N@28211|Alphaproteobacteria,3EYVW@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	Lysine methyltransferase	-	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009892,GO:0009894,GO:0009895,GO:0009987,GO:0010565,GO:0016278,GO:0016279,GO:0016740,GO:0016741,GO:0018022,GO:0018023,GO:0018193,GO:0018205,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031329,GO:0031330,GO:0031974,GO:0031998,GO:0031999,GO:0032259,GO:0036211,GO:0043086,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043414,GO:0043467,GO:0044092,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045833,GO:0045922,GO:0046320,GO:0046322,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0050994,GO:0050995,GO:0051341,GO:0051354,GO:0062012,GO:0062014,GO:0065007,GO:0065009,GO:0070013,GO:0071704,GO:0080090,GO:0140096,GO:1901564,GO:1904732,GO:1904733,GO:1904735,GO:1904736	-	-	-	-	-	-	-	-	-	-	PrmA
SHD2_k127_5387423_22	1245469.S58_70240	3.142e-165	528.0	COG0372@1|root,COG0372@2|Bacteria,1MXFW@1224|Proteobacteria,2TTMR@28211|Alphaproteobacteria,3JREW@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Citrate synthase, C-terminal domain	MA20_39855	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt,HTH_17,MerR_1
SHD2_k127_5387423_17	1298867.AUES01000019_gene3523	7.615e-180	569.0	COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,2TSU1@28211|Alphaproteobacteria,3JR3A@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Citrate synthase, C-terminal domain	citA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
SHD2_k127_5387423_23	1242864.D187_006962	5.49e-163	526.0	COG0531@1|root,COG0531@2|Bacteria,1MXNJ@1224|Proteobacteria,42PEH@68525|delta/epsilon subdivisions,2X5ME@28221|Deltaproteobacteria,2Z33D@29|Myxococcales	28221|Deltaproteobacteria	E	C-terminus of AA_permease	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
SHD2_k127_5387423_3	402881.Plav_0637	1.21e-272	844.0	COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,2TTSQ@28211|Alphaproteobacteria,1JP5H@119043|Rhodobiaceae	28211|Alphaproteobacteria	H	3-octaprenyl-4-hydroxybenzoate carboxy-lyase	ubiD	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
SHD2_k127_5387423_103	402881.Plav_0632	1.097e-21	100.0	COG3788@1|root,COG3788@2|Bacteria	2|Bacteria	S	relative of glutathione S-transferase, MAPEG superfamily	-	-	-	ko:K07136	-	-	-	-	ko00000	-	-	-	MAPEG
SHD2_k127_5387423_18	402881.Plav_0631	2.327e-172	551.0	COG0312@1|root,COG0312@2|Bacteria,1MUVW@1224|Proteobacteria,2TSAV@28211|Alphaproteobacteria,1JNTE@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Zn-dependent proteases and their inactivated homologs	pmbA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
SHD2_k127_5387423_56	402881.Plav_0630	2.206e-84	287.0	COG0483@1|root,COG0483@2|Bacteria,1MV4W@1224|Proteobacteria,2TV4R@28211|Alphaproteobacteria,1JP0Z@119043|Rhodobiaceae	28211|Alphaproteobacteria	G	Inositol monophosphatase family	suhB2	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
SHD2_k127_5387423_97	1121028.ARQE01000004_gene1520	9.708e-31	125.0	COG0483@1|root,COG0483@2|Bacteria,1N7D7@1224|Proteobacteria,2UF6T@28211|Alphaproteobacteria,2PK5Q@255475|Aurantimonadaceae	28211|Alphaproteobacteria	G	Domain of unknown function (DUF4170)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4170
SHD2_k127_5387423_29	1282876.BAOK01000001_gene2946	2.593e-143	476.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2TQMR@28211|Alphaproteobacteria,4BPS9@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	V	ABC-type multidrug transport system, ATPase and permease	msbA	-	-	ko:K02021,ko:K06147,ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106,3.A.1.109,3.A.1.110,3.A.1.112,3.A.1.113,3.A.1.117,3.A.1.21	-	-	ABC_membrane,ABC_tran
SHD2_k127_5387423_40	1187851.A33M_3443	6.325e-118	392.0	COG1519@1|root,COG1519@2|Bacteria,1MU9F@1224|Proteobacteria,2TS37@28211|Alphaproteobacteria,3FE6G@34008|Rhodovulum	28211|Alphaproteobacteria	M	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase)	kdtA	-	2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15	ko:K02527	ko00540,ko01100,map00540,map01100	M00060,M00080	R04658,R05074,R09763	RC00009,RC00077,RC00247	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT30	-	Glycos_transf_N
SHD2_k127_5387423_58	1380394.JADL01000003_gene5129	9.068e-82	283.0	COG1663@1|root,COG1663@2|Bacteria,1MU8G@1224|Proteobacteria,2TTZ4@28211|Alphaproteobacteria,2JPX7@204441|Rhodospirillales	204441|Rhodospirillales	M	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)	lpxK	-	2.7.1.130	ko:K00912	ko00540,ko01100,map00540,map01100	M00060	R04657	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxK
SHD2_k127_5387423_66	1380394.JADL01000003_gene5128	2.27e-70	250.0	COG1560@1|root,COG1560@2|Bacteria,1MVNI@1224|Proteobacteria,2TS2H@28211|Alphaproteobacteria,2JQV6@204441|Rhodospirillales	204441|Rhodospirillales	M	COG1560 Lauroyl myristoyl acyltransferase	-	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
SHD2_k127_5387423_72	1385515.N791_05255	2.977e-66	238.0	COG0739@1|root,COG0739@2|Bacteria,1MY2X@1224|Proteobacteria,1RMYN@1236|Gammaproteobacteria,1X4SW@135614|Xanthomonadales	135614|Xanthomonadales	M	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
SHD2_k127_5387423_104	1131814.JAFO01000001_gene1263	2.805e-21	94.0	COG3908@1|root,COG3908@2|Bacteria,1N7PA@1224|Proteobacteria,2UFTN@28211|Alphaproteobacteria,3F032@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2093)	MA20_05765	-	-	-	-	-	-	-	-	-	-	-	DUF2093
SHD2_k127_5387423_27	1282876.BAOK01000001_gene2953	4.688e-151	491.0	COG1570@1|root,COG1570@2|Bacteria,1MUA4@1224|Proteobacteria,2TR1R@28211|Alphaproteobacteria,4BPAS@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
SHD2_k127_5387423_21	316055.RPE_4612	7.942e-166	532.0	COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,2TQR5@28211|Alphaproteobacteria,3JSI5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	F	Belongs to the GARS family	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
SHD2_k127_5387423_25	1333998.M2A_1483	4.987e-161	515.0	COG3173@1|root,COG3173@2|Bacteria,1MWAK@1224|Proteobacteria,2TT2N@28211|Alphaproteobacteria,4BTBA@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Phosphotransferase enzyme family	MA20_31030	-	-	-	-	-	-	-	-	-	-	-	APH
SHD2_k127_5387423_13	1333998.M2A_1473	3.998e-195	618.0	COG1960@1|root,COG1960@2|Bacteria,1MU2V@1224|Proteobacteria,2TSK3@28211|Alphaproteobacteria,4BPRD@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	MA20_31035	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
SHD2_k127_5387423_110	1150469.RSPPHO_00647	1.7e-11	75.0	COG0671@1|root,COG0671@2|Bacteria,1N7CW@1224|Proteobacteria,2TRDP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	phosphoesterase, PA-phosphatase related	lpxE	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
SHD2_k127_5387423_63	1110502.TMO_1530	1.155e-76	264.0	COG0861@1|root,COG0861@2|Bacteria,1MWC9@1224|Proteobacteria,2TTT6@28211|Alphaproteobacteria,2JR9M@204441|Rhodospirillales	204441|Rhodospirillales	P	COG0861 Membrane protein TerC, possibly involved in tellurium resistance	-	-	-	-	-	-	-	-	-	-	-	-	TerC
SHD2_k127_5387423_69	402881.Plav_0557	2.05e-67	237.0	COG0625@1|root,COG0625@2|Bacteria,1MXJD@1224|Proteobacteria,2TS1B@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Glutathione S-transferase	gstch1	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_2,GST_N_3
SHD2_k127_5387423_33	1333998.M2A_1399	6.501e-134	434.0	COG0625@1|root,COG0625@2|Bacteria,1Q9ND@1224|Proteobacteria,2TT22@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	COG0625 Glutathione S-transferase	-	-	-	-	-	-	-	-	-	-	-	-	GST_C_2,GST_N_3
SHD2_k127_5387423_51	1248916.ANFY01000004_gene1723	5.93e-98	324.0	COG3917@1|root,COG3917@2|Bacteria,1MV6E@1224|Proteobacteria,2TVJ4@28211|Alphaproteobacteria,2K0YH@204457|Sphingomonadales	204457|Sphingomonadales	Q	2-hydroxychromene-2-carboxylate isomerase	-	-	-	-	-	-	-	-	-	-	-	-	DSBA
SHD2_k127_5387423_57	1280952.HJA_01675	6.746e-83	289.0	COG1234@1|root,COG1234@2|Bacteria,1R64Z@1224|Proteobacteria,2U0BA@28211|Alphaproteobacteria,43WZ6@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	COG1234 Metal-dependent hydrolases of the beta-lactamase superfamily III	-	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B,Lactamase_B_2
SHD2_k127_5387423_87	1282876.BAOK01000001_gene2960	2.663e-46	184.0	COG0590@1|root,COG0590@2|Bacteria,1RGU0@1224|Proteobacteria,2U77Q@28211|Alphaproteobacteria,4BQFQ@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	FJ	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)	tadA	-	3.5.4.1,3.5.4.3,3.5.4.33	ko:K01485,ko:K01487,ko:K11991	ko00230,ko00240,ko00330,ko01100,map00230,map00240,map00330,map01100	-	R00974,R01411,R01676,R02922,R10223	RC00074,RC00204,RC00477,RC00514,RC00809	ko00000,ko00001,ko01000,ko03016	-	-	-	MafB19-deam,dCMP_cyt_deam_1
SHD2_k127_5387423_53	1282876.BAOK01000001_gene2961	2.533e-94	322.0	COG1187@1|root,COG1187@2|Bacteria,1MUCE@1224|Proteobacteria,2TQP2@28211|Alphaproteobacteria,4BP8I@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	J	S4 RNA-binding domain	rluB	-	5.4.99.22	ko:K06178	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
SHD2_k127_5387423_79	1313172.YM304_15380	1.989e-58	220.0	COG3394@1|root,COG3394@2|Bacteria,2HG9M@201174|Actinobacteria,4CN7Z@84992|Acidimicrobiia	84992|Acidimicrobiia	G	YdjC-like protein	-	-	3.5.1.105	ko:K03478	-	-	-	-	ko00000,ko01000	-	-	-	YdjC
SHD2_k127_5387423_70	402881.Plav_0958	5.575e-67	236.0	COG0454@1|root,COG0456@2|Bacteria,1RGPR@1224|Proteobacteria,2U8D2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
SHD2_k127_5387423_26	395019.Bmul_1871	1.679e-153	497.0	COG2223@1|root,COG2223@2|Bacteria,1MXAA@1224|Proteobacteria,2VN1F@28216|Betaproteobacteria,1K0E3@119060|Burkholderiaceae	28216|Betaproteobacteria	P	PFAM major facilitator superfamily MFS_1	fsr	-	-	ko:K08223	-	-	-	-	ko00000,ko02000	2.A.1.35	-	-	MFS_1
SHD2_k127_5387423_37	1122604.JONR01000013_gene3243	6.767e-121	396.0	COG3511@1|root,COG3511@2|Bacteria,1R78F@1224|Proteobacteria,1S2GR@1236|Gammaproteobacteria,1X929@135614|Xanthomonadales	135614|Xanthomonadales	M	Phosphoesterase family	-	-	-	-	-	-	-	-	-	-	-	-	Phosphoesterase
SHD2_k127_5412153_1	402881.Plav_2850	1.093e-115	380.0	COG1946@1|root,COG1946@2|Bacteria,1MV9R@1224|Proteobacteria,2TRFD@28211|Alphaproteobacteria,1JMZB@119043|Rhodobiaceae	28211|Alphaproteobacteria	I	Thioesterase-like superfamily	tesB	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006629,GO:0006631,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016042,GO:0016054,GO:0016289,GO:0016787,GO:0016788,GO:0016790,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0042802,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0046483,GO:0047617,GO:0051186,GO:0055086,GO:0071704,GO:0072329,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901575	-	ko:K10805	ko01040,map01040	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	-	4HBT_3
SHD2_k127_5412153_0	1122963.AUHB01000003_gene3940	1.429e-138	452.0	COG5379@1|root,COG5379@2|Bacteria,1MWG8@1224|Proteobacteria,2TQKH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	S-adenosylmethionine diacylglycerol 3-amino-3-carboxypropyl transferase	btaA	-	-	ko:K13622	ko00564,map00564	-	R09072	RC00021,RC01091	ko00000,ko00001	-	-	-	DUF3419
SHD2_k127_5412153_2	1298858.AUEL01000011_gene5538	9.386e-56	205.0	COG0500@1|root,COG2226@2|Bacteria,1REUM@1224|Proteobacteria,2U75Q@28211|Alphaproteobacteria,43JP9@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	Q	Putative methyltransferase	btaB	-	-	ko:K13623	ko00564,map00564	-	R09073	RC00003,RC02308	ko00000,ko00001	-	-	-	Methyltransf_23,Methyltransf_25
SHD2_k127_5484590_15	1123229.AUBC01000043_gene1318	1.209e-18	90.0	COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,2TQP8@28211|Alphaproteobacteria,3JRYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
SHD2_k127_5484590_2	570952.ATVH01000006_gene3152	0.0	1055.0	COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,2TQVI@28211|Alphaproteobacteria,2JQXC@204441|Rhodospirillales	204441|Rhodospirillales	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
SHD2_k127_5484590_5	1333998.M2A_3261	1.82e-74	256.0	COG0049@1|root,COG0049@2|Bacteria,1MXC8@1224|Proteobacteria,2TSI8@28211|Alphaproteobacteria,4BQCS@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA	rpsG	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
SHD2_k127_5484590_7	314254.OA2633_03691	5.182e-68	231.0	COG0048@1|root,COG0048@2|Bacteria,1RCWY@1224|Proteobacteria,2U70K@28211|Alphaproteobacteria,43XMM@69657|Hyphomonadaceae	28211|Alphaproteobacteria	J	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit	rpsL	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
SHD2_k127_5484590_13	1408418.JNJH01000003_gene2296	1.856e-37	147.0	COG0494@1|root,COG0494@2|Bacteria	2|Bacteria	L	nUDIX hydrolase	-	-	3.6.1.17	ko:K01518,ko:K08296	ko00230,ko00240,map00230,map00240	-	R00184,R00969,R01232,R02805	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
SHD2_k127_5484590_12	509190.Cseg_3425	5.285e-47	174.0	COG5331@1|root,COG5331@2|Bacteria,1N0MD@1224|Proteobacteria,2UEP8@28211|Alphaproteobacteria,2KHFA@204458|Caulobacterales	204458|Caulobacterales	S	MAPEG family	-	-	-	-	-	-	-	-	-	-	-	-	MAPEG
SHD2_k127_5484590_14	1335760.ASTG01000008_gene972	1.232e-24	115.0	COG3637@1|root,COG3637@2|Bacteria,1PW82@1224|Proteobacteria,2U8GW@28211|Alphaproteobacteria,2K6DC@204457|Sphingomonadales	204457|Sphingomonadales	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_5484590_9	1144305.PMI02_04940	8.632e-60	221.0	COG1024@1|root,COG1024@2|Bacteria,1MVQN@1224|Proteobacteria,2U31Y@28211|Alphaproteobacteria,2K94N@204457|Sphingomonadales	204457|Sphingomonadales	I	Enoyl-CoA hydratase isomerase	-	-	5.3.3.18	ko:K15866	ko00360,ko01120,map00360,map01120	-	R09837,R09839	RC00004,RC00326,RC02689,RC03003	ko00000,ko00001,ko01000	-	-	-	ECH_1
SHD2_k127_5484590_10	1205680.CAKO01000029_gene5206	1.294e-59	216.0	COG0346@1|root,COG0346@2|Bacteria,1MW8Z@1224|Proteobacteria,2TS64@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	lactoylglutathione lyase activity	MA20_40050	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase_3
SHD2_k127_5484590_1	402881.Plav_2730	0.0	2075.0	COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,2TRHV@28211|Alphaproteobacteria,1JNCD@119043|Rhodobiaceae	28211|Alphaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03046,ko:K13797	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
SHD2_k127_5484590_0	1333998.M2A_3264	0.0	2147.0	COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,2TS7S@28211|Alphaproteobacteria,4BPI1@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
SHD2_k127_5484590_11	414684.RC1_0700	7.195e-51	183.0	COG0222@1|root,COG0222@2|Bacteria,1RGU4@1224|Proteobacteria,2U9FX@28211|Alphaproteobacteria,2JSU1@204441|Rhodospirillales	204441|Rhodospirillales	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation	rplL	-	-	ko:K02935	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L12,Ribosomal_L12_N
SHD2_k127_5484590_8	391937.NA2_20784	2.618e-63	224.0	COG0244@1|root,COG0244@2|Bacteria,1RAN5@1224|Proteobacteria,2U592@28211|Alphaproteobacteria,43IRW@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rplJ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
SHD2_k127_5484590_3	114615.BRADO3049	6.497e-105	346.0	COG0081@1|root,COG0081@2|Bacteria,1MUE6@1224|Proteobacteria,2TRXP@28211|Alphaproteobacteria,3JVAW@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
SHD2_k127_5484590_6	911045.PSE_3892	3.344e-68	233.0	COG0080@1|root,COG0080@2|Bacteria,1RA2M@1224|Proteobacteria,2U760@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rplK	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
SHD2_k127_5484590_4	402881.Plav_2724	3.982e-78	265.0	COG0250@1|root,COG0250@2|Bacteria,1MU14@1224|Proteobacteria,2TRID@28211|Alphaproteobacteria,1JNF5@119043|Rhodobiaceae	28211|Alphaproteobacteria	K	In Spt5p, this domain may confer affinity for Spt4p. It possesses a RNP-like fold.	nusG	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,NusG
SHD2_k127_5484590_17	1382303.JPOM01000001_gene1333	5.309e-17	83.0	COG0690@1|root,COG0690@2|Bacteria,1N75P@1224|Proteobacteria,2UF51@28211|Alphaproteobacteria,2KH7G@204458|Caulobacterales	204458|Caulobacterales	U	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation	secE	-	-	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecE
SHD2_k127_5484590_16	648757.Rvan_2978	9.485e-18	82.0	COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,2TQP8@28211|Alphaproteobacteria,3N6BR@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
SHD2_k127_5528193_0	1220535.IMCC14465_13940	6.431e-217	681.0	COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,2TSCJ@28211|Alphaproteobacteria,4BP9I@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
SHD2_k127_5528193_3	402881.Plav_2479	3.604e-188	591.0	COG1077@1|root,COG1077@2|Bacteria,1MUMW@1224|Proteobacteria,2TTQ2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	D	Rod shape-determining protein (MreB)	mreB	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
SHD2_k127_5528193_11	1282876.BAOK01000001_gene1417	1.642e-55	213.0	COG1792@1|root,COG1792@2|Bacteria,1N8ZS@1224|Proteobacteria,2U1FY@28211|Alphaproteobacteria,4BQP8@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	M	Involved in formation and maintenance of cell shape	mreC	-	-	ko:K03570	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreC
SHD2_k127_5528193_18	1333998.M2A_1319	9.863e-15	81.0	2DDTT@1|root,32U20@2|Bacteria,1N2J3@1224|Proteobacteria,2UCVI@28211|Alphaproteobacteria,4BR2A@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	shape-determining protein	mreD	-	-	ko:K03571	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreD
SHD2_k127_5528193_1	1282876.BAOK01000001_gene1419	2.43e-203	659.0	COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,2TRXN@28211|Alphaproteobacteria,4BPTZ@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	M	Penicillin-binding protein 2	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
SHD2_k127_5528193_8	1122137.AQXF01000003_gene2474	2.486e-123	413.0	COG0772@1|root,COG0772@2|Bacteria,1MUK3@1224|Proteobacteria,2TSM0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Peptidoglycan polymerase that is essential for cell wall elongation	mrdB	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
SHD2_k127_5528193_2	1125973.JNLC01000010_gene1421	6.273e-198	638.0	COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2TQVK@28211|Alphaproteobacteria,3JRND@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C2
SHD2_k127_5528193_13	1121106.JQKB01000005_gene2224	2.432e-51	189.0	COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,2U6Z6@28211|Alphaproteobacteria,2JSHT@204441|Rhodospirillales	204441|Rhodospirillales	C	[2Fe-2S] binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer2,Fer2_2
SHD2_k127_5528193_6	1005048.CFU_2789	2.2e-168	536.0	COG2021@1|root,COG2021@2|Bacteria,1MVJV@1224|Proteobacteria,2VMGR@28216|Betaproteobacteria,4751C@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	alpha/beta hydrolase fold	-	-	2.3.1.31	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	-	R01776	RC00004,RC00041	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
SHD2_k127_5528193_9	1280953.HOC_02621	6.231e-86	306.0	COG0673@1|root,COG0673@2|Bacteria,1MZIG@1224|Proteobacteria,2UB61@28211|Alphaproteobacteria,43YUF@69657|Hyphomonadaceae	28211|Alphaproteobacteria	E	Oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
SHD2_k127_5528193_12	118173.KB235910_gene5073	1.004e-51	196.0	COG3239@1|root,COG3239@2|Bacteria,1G2M3@1117|Cyanobacteria,1HA6T@1150|Oscillatoriales	1117|Cyanobacteria	I	PFAM Fatty acid desaturase	-	-	-	-	-	-	-	-	-	-	-	-	FA_desaturase
SHD2_k127_5528193_14	331869.BAL199_05839	4.183e-39	151.0	COG1846@1|root,COG1846@2|Bacteria,1N1CJ@1224|Proteobacteria,2UCHN@28211|Alphaproteobacteria,4BST4@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
SHD2_k127_5528193_10	257310.BB3255	3.083e-80	274.0	COG0625@1|root,COG0625@2|Bacteria,1RA4Y@1224|Proteobacteria,2VKEU@28216|Betaproteobacteria,3T1GJ@506|Alcaligenaceae	28216|Betaproteobacteria	O	Maleylacetoacetate isomerase	maiA	-	5.2.1.2,5.2.1.4	ko:K01800,ko:K01801	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R03181,R03868	RC00867	ko00000,ko00001,ko00002,ko01000	-	-	-	GST_C,GST_C_2,GST_C_3,GST_N,GST_N_3
SHD2_k127_5528193_7	883126.HMPREF9710_02173	1.325e-142	460.0	COG0179@1|root,COG0179@2|Bacteria,1MV0V@1224|Proteobacteria,2VGZX@28216|Betaproteobacteria,475T3@75682|Oxalobacteraceae	28216|Betaproteobacteria	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	3.7.1.2	ko:K16171	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R01364	RC00326,RC00446	ko00000,ko00001,ko00002,ko01000	-	-	-	FAA_hydrolase
SHD2_k127_5528193_4	1195246.AGRI_06362	1.337e-174	557.0	COG3508@1|root,COG3508@2|Bacteria,1MV9G@1224|Proteobacteria,1RQG2@1236|Gammaproteobacteria,464VD@72275|Alteromonadaceae	1236|Gammaproteobacteria	Q	Homogentisate 1,2-dioxygenase	hmgA	GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0003824,GO:0004411,GO:0005488,GO:0005506,GO:0005575,GO:0006082,GO:0006355,GO:0006520,GO:0006558,GO:0006559,GO:0006570,GO:0006572,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0017144,GO:0019219,GO:0019222,GO:0019439,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032991,GO:0032993,GO:0042737,GO:0043167,GO:0043169,GO:0043436,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0045892,GO:0045934,GO:0046395,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051213,GO:0051252,GO:0051253,GO:0055114,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0097159,GO:0140110,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1902221,GO:1902222,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141	1.13.11.5	ko:K00451	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R02519	RC00737	ko00000,ko00001,ko00002,ko01000	-	-	-	HgmA
SHD2_k127_5528193_5	1380394.JADL01000012_gene1023	1.184e-168	536.0	COG3185@1|root,COG3185@2|Bacteria,1MUVZ@1224|Proteobacteria,2TRCC@28211|Alphaproteobacteria,2JQJ4@204441|Rhodospirillales	204441|Rhodospirillales	E	Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal	-	-	1.13.11.27	ko:K00457	ko00130,ko00350,ko00360,ko01100,map00130,map00350,map00360,map01100	M00044	R01372,R02521	RC00505,RC00738	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Glyoxalase,Glyoxalase_5
SHD2_k127_5528193_17	1500304.JQKY01000019_gene644	2.143e-16	90.0	COG1276@1|root,COG1276@2|Bacteria,1P1D5@1224|Proteobacteria,2U4YY@28211|Alphaproteobacteria,4BMUF@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	Copper resistance protein D	copD	-	-	ko:K07245	-	-	-	-	ko00000,ko02000	9.B.62.1	-	-	CopD
SHD2_k127_5528193_15	349163.Acry_0868	1.991e-23	111.0	COG2847@1|root,COG2847@2|Bacteria	2|Bacteria	P	Copper chaperone PCu(A)C	-	-	-	ko:K09796	-	-	-	-	ko00000,ko03110	-	-	-	PCuAC
SHD2_k127_5528193_19	460265.Mnod_6630	9.376e-14	81.0	COG2372@1|root,COG2372@2|Bacteria,1N8SS@1224|Proteobacteria,2UFW5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Copper resistance protein	copC	-	-	ko:K07156	-	-	-	-	ko00000,ko02000	9.B.62.2	-	-	CopC
SHD2_k127_5528193_16	640511.BC1002_7177	1.274e-19	95.0	28HTF@1|root,2Z80A@2|Bacteria,1PEXH@1224|Proteobacteria,2W3AU@28216|Betaproteobacteria,1K43D@119060|Burkholderiaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_5531722_21	1121374.KB891575_gene1185	1.969e-33	132.0	COG1181@1|root,COG1181@2|Bacteria,1N4F5@1224|Proteobacteria,1SKJ8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	Belongs to the D-alanine--D-alanine ligase family	-	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
SHD2_k127_5531722_4	1121861.KB899916_gene1707	1.169e-185	593.0	COG1509@1|root,COG1509@2|Bacteria,1MUPJ@1224|Proteobacteria,2TT31@28211|Alphaproteobacteria,2JPK9@204441|Rhodospirillales	204441|Rhodospirillales	E	lysine 2,3-aminomutase	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
SHD2_k127_5531722_7	1238182.C882_2411	2.648e-112	386.0	COG1807@1|root,COG1807@2|Bacteria,1NMIZ@1224|Proteobacteria,2TRS4@28211|Alphaproteobacteria,2JQTC@204441|Rhodospirillales	204441|Rhodospirillales	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT,PMT_2
SHD2_k127_5531722_13	366602.Caul_4521	3.334e-78	271.0	COG1215@1|root,COG1215@2|Bacteria,1QVG6@1224|Proteobacteria,2TWF3@28211|Alphaproteobacteria,2KFY3@204458|Caulobacterales	204458|Caulobacterales	M	Glycosyl transferase family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
SHD2_k127_5531722_23	1121035.AUCH01000021_gene2720	4.236e-22	103.0	COG3952@1|root,COG3952@2|Bacteria,1MZ60@1224|Proteobacteria,2VWQ0@28216|Betaproteobacteria,2KZCH@206389|Rhodocyclales	206389|Rhodocyclales	S	Lipid A Biosynthesis N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	LAB_N
SHD2_k127_5531722_22	394221.Mmar10_2387	1.261e-24	108.0	2E6XE@1|root,331GU@2|Bacteria,1N7WP@1224|Proteobacteria,2UG23@28211|Alphaproteobacteria,440RN@69657|Hyphomonadaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_5531722_8	113395.AXAI01000002_gene5563	2.508e-108	370.0	COG0457@1|root,COG0457@2|Bacteria,1MVMG@1224|Proteobacteria,2TSGE@28211|Alphaproteobacteria,3JTGV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3,TPR_1,TPR_11,TPR_16,TPR_19,TPR_2,TPR_8
SHD2_k127_5531722_6	936455.KI421499_gene5763	4.081e-136	444.0	COG0604@1|root,COG0604@2|Bacteria,1MXUX@1224|Proteobacteria,2TTWF@28211|Alphaproteobacteria,3JTZF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
SHD2_k127_5531722_27	690585.JNNU01000008_gene3685	3.606e-10	69.0	2B41E@1|root,31WRS@2|Bacteria,1P8VA@1224|Proteobacteria,2TT81@28211|Alphaproteobacteria,4B73K@82115|Rhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_5531722_14	366602.Caul_3051	7.109e-78	268.0	COG4798@1|root,COG4798@2|Bacteria,1RHGZ@1224|Proteobacteria,2U7R8@28211|Alphaproteobacteria,2KJUA@204458|Caulobacterales	204458|Caulobacterales	S	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_5531722_0	883078.HMPREF9695_01066	1.903e-243	771.0	COG0427@1|root,COG0427@2|Bacteria,1MUGE@1224|Proteobacteria,2TZDG@28211|Alphaproteobacteria,3JQP8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Acetyl-CoA hydrolase/transferase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AcetylCoA_hyd_C
SHD2_k127_5531722_10	1122132.AQYH01000004_gene1605	4.515e-94	319.0	COG4857@1|root,COG4857@2|Bacteria,1MXBW@1224|Proteobacteria,2TR0Z@28211|Alphaproteobacteria,4BD98@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
SHD2_k127_5531722_15	1502850.FG91_02806	5.634e-73	252.0	COG0346@1|root,COG0346@2|Bacteria,1MWCV@1224|Proteobacteria,2U6HU@28211|Alphaproteobacteria,2KANC@204457|Sphingomonadales	204457|Sphingomonadales	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
SHD2_k127_5531722_11	1163407.UU7_03612	7.714e-80	281.0	2C8CD@1|root,2Z9AD@2|Bacteria,1N17D@1224|Proteobacteria,1RRIP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_5531722_25	1380391.JIAS01000011_gene4859	7.492e-17	88.0	COG5388@1|root,COG5388@2|Bacteria,1N0UI@1224|Proteobacteria,2UCZU@28211|Alphaproteobacteria,2JTNR@204441|Rhodospirillales	204441|Rhodospirillales	S	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	PAS_5
SHD2_k127_5531722_2	1121124.JNIX01000008_gene2648	6.404e-210	666.0	COG0477@1|root,COG0477@2|Bacteria,1MU46@1224|Proteobacteria,2TRAP@28211|Alphaproteobacteria,2KEXI@204458|Caulobacterales	204458|Caulobacterales	EGP	Major Facilitator	-	-	-	-	-	-	-	-	-	-	-	-	Sugar_tr
SHD2_k127_5531722_17	1461693.ATO10_05242	9.827e-61	213.0	COG1522@1|root,COG1522@2|Bacteria,1MXVU@1224|Proteobacteria,2TTCK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Transcriptional	lrp	GO:0001101,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006355,GO:0006520,GO:0006522,GO:0006524,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009078,GO:0009080,GO:0009889,GO:0009987,GO:0010033,GO:0010243,GO:0010468,GO:0010556,GO:0016054,GO:0019219,GO:0019222,GO:0019752,GO:0031323,GO:0031326,GO:0042221,GO:0043200,GO:0043201,GO:0043436,GO:0043565,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1901698,GO:1901700,GO:1903506,GO:2000112,GO:2001141	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_24
SHD2_k127_5531722_5	570952.ATVH01000013_gene2640	2.377e-140	452.0	COG0492@1|root,COG0492@2|Bacteria,1MV15@1224|Proteobacteria,2TRBW@28211|Alphaproteobacteria,2JPS7@204441|Rhodospirillales	204441|Rhodospirillales	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	trxB	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
SHD2_k127_5531722_9	1528106.JRJE01000008_gene1539	6.054e-101	337.0	COG0583@1|root,COG0583@2|Bacteria,1MV5N@1224|Proteobacteria,2TRAX@28211|Alphaproteobacteria,2JPCC@204441|Rhodospirillales	204441|Rhodospirillales	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
SHD2_k127_5531722_12	1380394.JADL01000001_gene2805	2.768e-78	266.0	COG1704@1|root,COG1704@2|Bacteria,1MVH0@1224|Proteobacteria,2U6EM@28211|Alphaproteobacteria,2JUH0@204441|Rhodospirillales	204441|Rhodospirillales	S	LemA family	-	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
SHD2_k127_5531722_18	1380394.JADL01000001_gene2806	3.208e-53	201.0	COG1512@1|root,COG1512@2|Bacteria,1PB41@1224|Proteobacteria,2TUVD@28211|Alphaproteobacteria,2JUI2@204441|Rhodospirillales	204441|Rhodospirillales	S	TPM domain	-	-	-	-	-	-	-	-	-	-	-	-	TPM_phosphatase
SHD2_k127_5531722_26	1437448.AZRT01000002_gene2297	1.35e-14	84.0	COG3762@1|root,COG3762@2|Bacteria,1R61N@1224|Proteobacteria,2U5XG@28211|Alphaproteobacteria,1J2PW@118882|Brucellaceae	28211|Alphaproteobacteria	S	membrane	-	-	-	ko:K08988	-	-	-	-	ko00000	-	-	-	TPM_phosphatase
SHD2_k127_5531722_1	1245469.S58_61410	2.331e-241	764.0	COG0480@1|root,COG0480@2|Bacteria,1MU2W@1224|Proteobacteria,2TYVK@28211|Alphaproteobacteria,3JQUI@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	J	elongation factor G	MA20_05220	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
SHD2_k127_5531722_24	573065.Astex_3228	2.774e-17	87.0	2ED82@1|root,3374K@2|Bacteria,1N90K@1224|Proteobacteria,2UMHT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	CVNH domain	-	-	-	-	-	-	-	-	-	-	-	-	CVNH
SHD2_k127_5531722_16	1163407.UU7_03612	1.551e-69	251.0	2C8CD@1|root,2Z9AD@2|Bacteria,1N17D@1224|Proteobacteria,1RRIP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_5531722_3	1333998.M2A_2360	8.984e-203	637.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,2TRPK@28211|Alphaproteobacteria,4BPDV@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	PFAM Aminotransferase class I and II	aatA	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
SHD2_k127_5531722_19	1380391.JIAS01000012_gene4473	1.803e-42	160.0	COG3169@1|root,COG3169@2|Bacteria,1RHBQ@1224|Proteobacteria,2U9M1@28211|Alphaproteobacteria,2JTES@204441|Rhodospirillales	204441|Rhodospirillales	S	Putative member of DMT superfamily (DUF486)	-	-	-	ko:K09922	-	-	-	-	ko00000	-	-	-	DMT_6
SHD2_k127_5531722_20	190650.CC_2031	1.658e-34	141.0	COG3063@1|root,COG3063@2|Bacteria,1QVFJ@1224|Proteobacteria,2TWDP@28211|Alphaproteobacteria,2KGVC@204458|Caulobacterales	204458|Caulobacterales	NU	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2,TPR_8
SHD2_k127_5638979_1	153496.JNAB01000016_gene2064	7.546e-122	406.0	COG0845@1|root,COG0845@2|Bacteria,1MVAS@1224|Proteobacteria,2TTGG@28211|Alphaproteobacteria,2JT2J@204441|Rhodospirillales	204441|Rhodospirillales	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	-	-	-	-	-	-	-	-	-	-	-	-	CusF_Ec,HlyD_D23,HlyD_D4
SHD2_k127_5638979_0	1380394.JADL01000009_gene3362	0.0	1517.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2TRWM@28211|Alphaproteobacteria,2JV3Y@204441|Rhodospirillales	204441|Rhodospirillales	P	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
SHD2_k127_5638979_2	1280947.HY30_08440	1.131e-31	126.0	COG2761@1|root,COG2761@2|Bacteria,1REE7@1224|Proteobacteria	1224|Proteobacteria	Q	DSBA-like thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	DSBA
SHD2_k127_5717227_2	1192868.CAIU01000020_gene2810	5.534e-132	427.0	COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,2TRUY@28211|Alphaproteobacteria,43N7T@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	O	prohibitin homologues	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
SHD2_k127_5717227_0	323097.Nham_3076	1.106e-215	676.0	COG5659@1|root,COG5659@2|Bacteria,1MXSV@1224|Proteobacteria,2TRKD@28211|Alphaproteobacteria,3JTXJ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
SHD2_k127_5717227_1	1101192.KB910516_gene657	1.111e-161	516.0	COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,2TSA7@28211|Alphaproteobacteria,1JSGY@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	Transposase domain (DUF772)	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
SHD2_k127_5717227_3	323097.Nham_3076	4.739e-06	52.0	COG5659@1|root,COG5659@2|Bacteria,1MXSV@1224|Proteobacteria,2TRKD@28211|Alphaproteobacteria,3JTXJ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
SHD2_k127_5858187_7	1280950.HJO_05975	2.051e-35	137.0	COG0385@1|root,COG0385@2|Bacteria,1MUMM@1224|Proteobacteria,2TU7J@28211|Alphaproteobacteria,43ZQ1@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	SBF-like CPA transporter family (DUF4137)	-	-	-	ko:K14347	-	-	-	-	ko00000,ko02000,ko04147	2.A.93.1	-	-	SBF_like
SHD2_k127_5858187_3	366602.Caul_1068	3.301e-70	246.0	COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,2TRYS@28211|Alphaproteobacteria,2KFTA@204458|Caulobacterales	204458|Caulobacterales	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
SHD2_k127_5858187_5	1549858.MC45_10110	4.265e-51	192.0	COG0526@1|root,COG0526@2|Bacteria,1N81A@1224|Proteobacteria,2UGCI@28211|Alphaproteobacteria,2KE3D@204457|Sphingomonadales	204457|Sphingomonadales	CO	Thioredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_7
SHD2_k127_5858187_0	1096546.WYO_2150	3.092e-244	771.0	COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,2TRCK@28211|Alphaproteobacteria,1JRCG@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	PFAM peptidase M3A and M3B thimet oligopeptidase F	dcp	GO:0003674,GO:0003824,GO:0004180,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0016787,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.15.5	ko:K01284	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3
SHD2_k127_5858187_2	1121935.AQXX01000140_gene1030	5.189e-120	404.0	COG4166@1|root,COG4166@2|Bacteria,1P91R@1224|Proteobacteria,1RN57@1236|Gammaproteobacteria,1XHY0@135619|Oceanospirillales	135619|Oceanospirillales	E	Peptide ABC transporter substrate-binding protein	-	-	-	ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	SBP_bac_5
SHD2_k127_5858187_1	1122137.AQXF01000006_gene816	1.525e-192	621.0	COG1164@1|root,COG1164@2|Bacteria,1MXAC@1224|Proteobacteria,2TRPY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	oligoendopeptidase F	-	-	-	ko:K08602	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3,Peptidase_M3_N
SHD2_k127_5858187_6	1122929.KB908217_gene206	1.319e-42	167.0	COG2968@1|root,COG2968@2|Bacteria,1RH7T@1224|Proteobacteria,2U981@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Membrane	omp28	GO:0005575,GO:0005623,GO:0042597,GO:0044464	-	ko:K09807	-	-	-	-	ko00000	-	-	-	SIMPL
SHD2_k127_5858187_4	743836.AYNA01000128_gene1406	5.513e-61	217.0	COG1961@1|root,COG1961@2|Bacteria,1MWCZ@1224|Proteobacteria,2TRIY@28211|Alphaproteobacteria,36ZIS@31993|Methylocystaceae	28211|Alphaproteobacteria	L	Resolvase, N terminal domain	-	-	-	ko:K06400	-	-	-	-	ko00000	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
SHD2_k127_6029072_2	1120934.KB894419_gene2119	1.182e-58	214.0	COG2936@1|root,COG2936@2|Bacteria,2GKZH@201174|Actinobacteria,4E0CY@85010|Pseudonocardiales	201174|Actinobacteria	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
SHD2_k127_6029072_0	1120983.KB894573_gene91	4.69e-177	562.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TVS9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
SHD2_k127_6029072_1	1123501.KB902290_gene1565	1.216e-59	209.0	COG1024@1|root,COG1024@2|Bacteria,1MVB1@1224|Proteobacteria,2TVK3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Catalyzes the conversion of feruloyl-CoA to vanillin and acetyl-CoA	-	-	4.1.2.41,4.2.1.101	ko:K18383	ko00360,ko01100,ko01110,map00360,map01100,map01110	-	R05772,R05773	RC00307,RC01468,RC01828	ko00000,ko00001,ko01000	-	-	-	ECH_1
SHD2_k127_6036018_2	1382303.JPOM01000001_gene23	3.513e-35	138.0	COG4638@1|root,COG4638@2|Bacteria,1MWXW@1224|Proteobacteria,2TSJ5@28211|Alphaproteobacteria,2KFDB@204458|Caulobacterales	204458|Caulobacterales	P	Ring hydroxylating alpha subunit (catalytic domain)	-	-	-	-	-	-	-	-	-	-	-	-	Rieske,Ring_hydroxyl_A
SHD2_k127_6036018_1	402881.Plav_3102	5.712e-93	310.0	COG0625@1|root,COG0625@2|Bacteria,1Q05U@1224|Proteobacteria,2TTDK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Glutathione S-transferase	-	-	-	-	-	-	-	-	-	-	-	-	GST_C,GST_C_2,GST_N,GST_N_3
SHD2_k127_6036018_0	1123261.AXDW01000001_gene1213	7.238e-232	733.0	COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,1RN6S@1236|Gammaproteobacteria,1X3SK@135614|Xanthomonadales	1236|Gammaproteobacteria	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
SHD2_k127_6195106_7	1333998.M2A_0667	1.417e-183	578.0	COG0183@1|root,COG0183@2|Bacteria,1MU8C@1224|Proteobacteria,2TS6P@28211|Alphaproteobacteria,4BP5Q@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	I	Thiolase, C-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
SHD2_k127_6195106_27	1333998.M2A_0668	3.546e-46	171.0	COG1545@1|root,COG1545@2|Bacteria,1RFF1@1224|Proteobacteria,2UTI3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	DUF35 OB-fold domain, acyl-CoA-associated	-	-	-	-	-	-	-	-	-	-	-	-	DUF35_N,OB_aCoA_assoc
SHD2_k127_6195106_12	1408418.JNJH01000023_gene123	8.325e-138	444.0	COG0667@1|root,COG0667@2|Bacteria,1MV2Y@1224|Proteobacteria,2TS02@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
SHD2_k127_6195106_11	1205680.CAKO01000037_gene1326	2.097e-138	449.0	COG2130@1|root,COG2130@2|Bacteria,1MUC2@1224|Proteobacteria,2TQYM@28211|Alphaproteobacteria,2JQXG@204441|Rhodospirillales	204441|Rhodospirillales	S	N-terminal domain of oxidoreductase	-	-	-	ko:K07119	-	-	-	-	ko00000	-	-	-	ADH_N_2,ADH_zinc_N
SHD2_k127_6195106_28	768671.ThimaDRAFT_3647	3.708e-39	155.0	COG5522@1|root,COG5522@2|Bacteria,1MYKS@1224|Proteobacteria,1SEKW@1236|Gammaproteobacteria,1X04I@135613|Chromatiales	135613|Chromatiales	S	Integral membrane protein (intg_mem_TP0381)	-	-	-	-	-	-	-	-	-	-	-	-	Intg_mem_TP0381
SHD2_k127_6195106_34	864069.MicloDRAFT_00048640	3.491e-23	108.0	COG2388@1|root,COG2388@2|Bacteria,1N8AQ@1224|Proteobacteria,2UFVS@28211|Alphaproteobacteria,1JWCN@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	GCN5-related N-acetyl-transferase	-	-	-	ko:K06975	-	-	-	-	ko00000	-	-	-	Acetyltransf_CG
SHD2_k127_6195106_25	715226.ABI_07750	7.184e-64	229.0	COG2860@1|root,COG2860@2|Bacteria,1RHQN@1224|Proteobacteria,2U6ZM@28211|Alphaproteobacteria,2KGHE@204458|Caulobacterales	204458|Caulobacterales	S	UPF0126 domain	-	-	-	-	-	-	-	-	-	-	-	-	UPF0126
SHD2_k127_6195106_14	1207063.P24_00510	1.142e-130	435.0	COG0645@1|root,COG2187@1|root,COG0645@2|Bacteria,COG2187@2|Bacteria,1MU9M@1224|Proteobacteria,2TQJN@28211|Alphaproteobacteria,2JPG5@204441|Rhodospirillales	204441|Rhodospirillales	S	AAA domain	-	-	-	ko:K07028	-	-	-	-	ko00000	-	-	-	AAA_33,APH
SHD2_k127_6195106_32	426117.M446_3904	2.628e-26	117.0	2C6BU@1|root,32S87@2|Bacteria,1NIFE@1224|Proteobacteria,2UIAW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_6195106_15	414684.RC1_1580	1.286e-117	382.0	COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,2TR2I@28211|Alphaproteobacteria,2JQ66@204441|Rhodospirillales	204441|Rhodospirillales	Q	COG1127 ABC-type transport system involved in resistance to organic solvents, ATPase component	mkl	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
SHD2_k127_6195106_18	402881.Plav_3483	5.028e-99	332.0	COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,2TSGS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	ABC-type transport system involved in resistance to organic solvents permease component	mlaE	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
SHD2_k127_6195106_33	1123229.AUBC01000007_gene112	1.268e-23	103.0	2EB0P@1|root,3351I@2|Bacteria,1NAEB@1224|Proteobacteria,2UG0E@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_6195106_1	224911.27352915	1.206e-285	890.0	COG2312@1|root,COG2518@1|root,COG2312@2|Bacteria,COG2518@2|Bacteria,1MU2S@1224|Proteobacteria,2TWB5@28211|Alphaproteobacteria,3JUQU@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	Erythro_esteras,PCMT,Pribosyltran
SHD2_k127_6195106_19	1122164.JHWF01000003_gene2046	9.476e-95	321.0	COG0845@1|root,COG0845@2|Bacteria,1P540@1224|Proteobacteria,1S264@1236|Gammaproteobacteria,1JDU0@118969|Legionellales	118969|Legionellales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
SHD2_k127_6195106_9	1268635.Loa_00331	6.781e-173	552.0	COG4591@1|root,COG4591@2|Bacteria,1Q2BY@1224|Proteobacteria,1RYDZ@1236|Gammaproteobacteria,1JE39@118969|Legionellales	118969|Legionellales	M	MacB-like periplasmic core domain	-	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
SHD2_k127_6195106_21	1268635.Loa_00332	3.12e-87	295.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,1RZ6P@1236|Gammaproteobacteria,1JE1S@118969|Legionellales	118969|Legionellales	P	Lipoprotein-releasing system ATP-binding protein LolD	-	-	-	ko:K09810	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.125	-	-	ABC_tran
SHD2_k127_6195106_35	1123256.KB907932_gene2994	3.578e-23	101.0	COG4572@1|root,COG4572@2|Bacteria,1N93H@1224|Proteobacteria,1S94E@1236|Gammaproteobacteria,1X8WH@135614|Xanthomonadales	135614|Xanthomonadales	S	Cation transport regulator	chaB	-	-	ko:K06197	-	-	-	-	ko00000	-	-	-	ChaB
SHD2_k127_6195106_3	1429916.X566_00330	1.252e-256	805.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,2TRNK@28211|Alphaproteobacteria,3JVXA@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	-	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
SHD2_k127_6195106_26	1123393.KB891326_gene40	7.281e-51	186.0	COG3108@1|root,COG3108@2|Bacteria,1MWW2@1224|Proteobacteria,2VRCS@28216|Betaproteobacteria,1KS6A@119069|Hydrogenophilales	119069|Hydrogenophilales	S	Bacterial protein of unknown function (DUF882)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M15_2
SHD2_k127_6195106_22	1449049.JONW01000007_gene3937	8.872e-81	289.0	COG2989@1|root,COG2989@2|Bacteria,1MV14@1224|Proteobacteria,2TRJ9@28211|Alphaproteobacteria,2KF4H@204458|Caulobacterales	204458|Caulobacterales	S	L,D-transpeptidase catalytic domain	-	-	-	ko:K21470,ko:K21572	-	-	-	-	ko00000,ko01002,ko01011,ko02000	8.A.46.1,8.A.46.3	-	-	PG_binding_1,YkuD
SHD2_k127_6195106_30	1221522.B723_15010	1.141e-32	135.0	COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,1SWNR@1236|Gammaproteobacteria,1YQ7Z@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
SHD2_k127_6195106_10	1380394.JADL01000003_gene4877	1.393e-145	467.0	COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,2TTI9@28211|Alphaproteobacteria,2JR9U@204441|Rhodospirillales	204441|Rhodospirillales	S	Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N
SHD2_k127_6195106_20	1297742.A176_02256	5.081e-89	304.0	COG1105@1|root,COG1105@2|Bacteria,1MVNW@1224|Proteobacteria,42U95@68525|delta/epsilon subdivisions,2WQWB@28221|Deltaproteobacteria,2YYF7@29|Myxococcales	28221|Deltaproteobacteria	H	Phosphomethylpyrimidine kinase	-	-	2.7.1.11	ko:K16370	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00345	R00756,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PfkB
SHD2_k127_6195106_29	402881.Plav_2520	1.461e-36	143.0	COG0633@1|root,COG0633@2|Bacteria,1RHDC@1224|Proteobacteria,2U97J@28211|Alphaproteobacteria,1JPAB@119043|Rhodobiaceae	28211|Alphaproteobacteria	C	2Fe-2S iron-sulfur cluster binding domain	fdx	-	-	ko:K04755	-	-	-	-	ko00000	-	-	-	Fer2
SHD2_k127_6195106_8	1282876.BAOK01000002_gene502	5.057e-175	556.0	COG0208@1|root,COG0208@2|Bacteria,1R4T3@1224|Proteobacteria,2U55H@28211|Alphaproteobacteria	28211|Alphaproteobacteria	F	P-aminobenzoate N-oxygenase AurF	-	-	-	-	-	-	-	-	-	-	-	-	AurF
SHD2_k127_6195106_6	366602.Caul_3622	9.339e-225	719.0	COG1472@1|root,COG1472@2|Bacteria,1MVIV@1224|Proteobacteria,2TS28@28211|Alphaproteobacteria,2KHQI@204458|Caulobacterales	204458|Caulobacterales	G	PFAM glycoside hydrolase family 3 domain protein	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
SHD2_k127_6195106_23	366602.Caul_1441	1.011e-76	270.0	COG0837@1|root,COG0837@2|Bacteria,1MVFI@1224|Proteobacteria,2U0CA@28211|Alphaproteobacteria,2KGB6@204458|Caulobacterales	204458|Caulobacterales	F	Belongs to the bacterial glucokinase family	glk	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucokinase
SHD2_k127_6195106_13	59538.XP_005961802.1	6.122e-137	449.0	COG0738@1|root,2QPVD@2759|Eukaryota,38F9Q@33154|Opisthokonta,3BTYW@33208|Metazoa,3DBWH@33213|Bilateria	33208|Metazoa	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SHD2_k127_6195106_0	398525.KB900701_gene6543	0.0	1095.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,2TR38@28211|Alphaproteobacteria,3JU74@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	ppsA	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
SHD2_k127_6195106_4	366602.Caul_3942	1.993e-243	769.0	COG0457@1|root,COG0457@2|Bacteria,1MVMG@1224|Proteobacteria,2TSGE@28211|Alphaproteobacteria,2KFVS@204458|Caulobacterales	204458|Caulobacterales	S	Sulfotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3,TPR_14,TPR_16,TPR_19,TPR_8
SHD2_k127_6195106_2	366602.Caul_3941	4.064e-275	869.0	COG1629@1|root,COG1629@2|Bacteria,1QUTW@1224|Proteobacteria,2TW7F@28211|Alphaproteobacteria,2KFR5@204458|Caulobacterales	204458|Caulobacterales	P	receptor	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
SHD2_k127_6195106_5	314225.ELI_02000	4.824e-238	746.0	COG0318@1|root,COG0318@2|Bacteria,1MVJ1@1224|Proteobacteria,2TUQ9@28211|Alphaproteobacteria,2K3JP@204457|Sphingomonadales	204457|Sphingomonadales	IQ	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II	-	-	6.2.1.42	ko:K00666,ko:K18688	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
SHD2_k127_6195106_16	1380355.JNIJ01000006_gene3042	1.367e-117	385.0	COG4705@1|root,COG4705@2|Bacteria,1MVMJ@1224|Proteobacteria,2TS5R@28211|Alphaproteobacteria,3JQKX@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Repeat of Unknown Function (DUF347)	-	-	-	-	-	-	-	-	-	-	-	-	DUF347
SHD2_k127_6195106_17	288000.BBta_3654	2.467e-102	338.0	COG1814@1|root,COG1814@2|Bacteria,1MUZE@1224|Proteobacteria,2TT6M@28211|Alphaproteobacteria,3JRM0@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	VIT family	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
SHD2_k127_6195106_24	1120973.AQXL01000121_gene68	1.175e-69	251.0	COG0477@1|root,COG2814@2|Bacteria,1TPPY@1239|Firmicutes,4HNJ9@91061|Bacilli,27A8T@186823|Alicyclobacillaceae	91061|Bacilli	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SHD2_k127_6195106_31	670307.HYPDE_25673	3.666e-27	114.0	COG2010@1|root,COG2010@2|Bacteria,1NPVI@1224|Proteobacteria,2UN8E@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_6212672_1	1192124.LIG30_0377	8.237e-105	350.0	28HQ7@1|root,2Z7XZ@2|Bacteria,1P3WR@1224|Proteobacteria,2W1SS@28216|Betaproteobacteria	28216|Betaproteobacteria	S	RES	-	-	-	-	-	-	-	-	-	-	-	-	RES
SHD2_k127_6212672_3	224911.27348281	4.758e-66	227.0	COG2963@1|root,COG2963@2|Bacteria,1N7V0@1224|Proteobacteria,2UFGY@28211|Alphaproteobacteria,3K695@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Transposase	-	-	-	ko:K07483	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
SHD2_k127_6212672_2	1038867.AXAY01000030_gene7134	3.432e-72	243.0	COG3436@1|root,COG3436@2|Bacteria,1RHDW@1224|Proteobacteria,2U7TH@28211|Alphaproteobacteria,3JZ4X@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	IS66 Orf2	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	TnpB_IS66
SHD2_k127_6212672_0	319003.Bra1253DRAFT_00709	1.43e-322	991.0	COG4372@1|root,COG4372@2|Bacteria,1MUCX@1224|Proteobacteria,2TR59@28211|Alphaproteobacteria,3JT7K@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66
SHD2_k127_6212672_4	1298867.AUES01000045_gene3529	1.872e-53	189.0	2EDJQ@1|root,337FH@2|Bacteria,1N02J@1224|Proteobacteria,2UCJ1@28211|Alphaproteobacteria,3K04B@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_6300536_2	1298867.AUES01000032_gene1971	7.998e-21	93.0	COG2984@1|root,COG2984@2|Bacteria,1P32C@1224|Proteobacteria,2UUN9@28211|Alphaproteobacteria,3K51X@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC_sub_bind
SHD2_k127_6300536_1	717785.HYPMC_3257	3.077e-198	627.0	COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,2TSA7@28211|Alphaproteobacteria,3N8ZI@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
SHD2_k127_6300536_0	1380355.JNIJ01000069_gene5660	3.878e-259	802.0	COG1014@1|root,COG4231@1|root,COG1014@2|Bacteria,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,2TSHH@28211|Alphaproteobacteria,3JSRZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	MA20_35585	-	1.2.7.8	ko:K04090	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR,TPP_enzyme_C
SHD2_k127_6352745_2	991905.SL003B_1307	0.0	1120.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,2TQTG@28211|Alphaproteobacteria,4BTG1@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	H	Vitamin B12 dependent methionine synthase, activation domain	metH	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008270,GO:0008276,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019538,GO:0019752,GO:0019842,GO:0031419,GO:0032259,GO:0034641,GO:0035999,GO:0036094,GO:0036211,GO:0042084,GO:0042558,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0050667,GO:0051186,GO:0071704,GO:0097159,GO:0140096,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
SHD2_k127_6352745_50	402881.Plav_2401	1.01e-122	402.0	COG0685@1|root,COG0685@2|Bacteria,1MUC9@1224|Proteobacteria,2TQZA@28211|Alphaproteobacteria,1JNKJ@119043|Rhodobiaceae	28211|Alphaproteobacteria	E	Methylenetetrahydrofolate reductase	metF	GO:0003674,GO:0003824,GO:0004489,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
SHD2_k127_6352745_64	402881.Plav_2400	8.815e-99	332.0	COG0500@1|root,COG0640@1|root,COG0640@2|Bacteria,COG2226@2|Bacteria,1NFSV@1224|Proteobacteria,2TSMV@28211|Alphaproteobacteria,1JNHA@119043|Rhodobiaceae	28211|Alphaproteobacteria	KQ	O-methyltransferase	arsR	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5,Methyltransf_11,Methyltransf_31
SHD2_k127_6352745_74	1244869.H261_19998	2.088e-58	212.0	COG2853@1|root,COG2853@2|Bacteria,1MVX0@1224|Proteobacteria,2U7CZ@28211|Alphaproteobacteria,2JS21@204441|Rhodospirillales	204441|Rhodospirillales	M	MlaA lipoprotein	-	-	-	ko:K04754	-	-	-	-	ko00000	-	-	-	MlaA
SHD2_k127_6352745_89	1382303.JPOM01000001_gene533	1.044e-33	139.0	COG2854@1|root,COG2854@2|Bacteria,1NKFA@1224|Proteobacteria,2UAPV@28211|Alphaproteobacteria,2KIM2@204458|Caulobacterales	204458|Caulobacterales	Q	MlaC protein	-	-	-	ko:K07323	ko02010,map02010	M00210	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27.3	-	-	MlaC
SHD2_k127_6352745_7	1282876.BAOK01000001_gene1331	8.859e-283	877.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2TS7G@28211|Alphaproteobacteria,4BPPN@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	ABC transporter	chvD	-	-	ko:K15738	-	-	-	-	ko00000,ko02000	3.A.1.120.6	-	-	ABC_tran,ABC_tran_Xtn
SHD2_k127_6352745_70	69395.JQLZ01000002_gene998	9.908e-94	312.0	COG0491@1|root,COG0491@2|Bacteria,1MUDN@1224|Proteobacteria,2TQJ9@28211|Alphaproteobacteria,2KG0M@204458|Caulobacterales	204458|Caulobacterales	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
SHD2_k127_6352745_55	1280953.HOC_11887	9.397e-109	360.0	COG1024@1|root,COG1024@2|Bacteria,1MVPQ@1224|Proteobacteria,2TTJ4@28211|Alphaproteobacteria,43WC8@69657|Hyphomonadaceae	28211|Alphaproteobacteria	I	enoyl-CoA hydratase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
SHD2_k127_6352745_57	876269.ARWA01000001_gene363	2.315e-106	355.0	COG1028@1|root,COG1028@2|Bacteria,1P9R4@1224|Proteobacteria,2TTJ5@28211|Alphaproteobacteria,3NBGD@45404|Beijerinckiaceae	28211|Alphaproteobacteria	IQ	KR domain	-	-	1.3.1.33	ko:K00218	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03845,R06286	RC01008	ko00000,ko00001,ko01000	-	-	-	adh_short
SHD2_k127_6352745_3	59538.XP_005973516.1	0.0	1104.0	COG1024@1|root,KOG1683@2759|Eukaryota,38EVG@33154|Opisthokonta,3BFIY@33208|Metazoa,3CV6V@33213|Bilateria,486GH@7711|Chordata,48YPX@7742|Vertebrata,3J9Y4@40674|Mammalia	33208|Metazoa	I	Belongs to the enoyl-CoA hydratase isomerase family	ech-8	-	1.1.1.35,4.2.1.17,5.3.3.8	ko:K00022,ko:K07514	ko00062,ko00071,ko00280,ko00281,ko00310,ko00380,ko00410,ko00627,ko00640,ko00650,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko03320,ko04146,map00062,map00071,map00280,map00281,map00310,map00380,map00410,map00627,map00640,map00650,map00930,map01100,map01110,map01120,map01130,map01200,map01212,map03320,map04146	M00013,M00032,M00085,M00087	R01778,R01975,R03026,R03045,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04743,R04744,R04745,R04746,R04748,R04749,R04756,R05066,R05595,R06941,R06942,R08094	RC00029,RC00099,RC00103,RC00117,RC00241,RC00525,RC00831,RC00834,RC01078,RC01086,RC01095,RC01098,RC01103	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
SHD2_k127_6352745_87	667632.KB890198_gene1193	2.562e-35	138.0	COG0848@1|root,COG0848@2|Bacteria,1RHDF@1224|Proteobacteria,2VT16@28216|Betaproteobacteria,1K73G@119060|Burkholderiaceae	28216|Betaproteobacteria	U	Biopolymer transport protein ExbD/TolR	exbD2	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
SHD2_k127_6352745_49	402881.Plav_2623	2.309e-123	399.0	COG2267@1|root,COG2267@2|Bacteria,1PFMC@1224|Proteobacteria,2UG1M@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
SHD2_k127_6352745_22	1211815.CBYP010000063_gene1887	2.969e-194	617.0	COG0318@1|root,COG0318@2|Bacteria,2GJAA@201174|Actinobacteria,4EUT2@85013|Frankiales	201174|Actinobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	6.2.1.7	ko:K15868	ko00121,map00121	-	-	-	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C
SHD2_k127_6352745_23	59538.XP_005973954.1	8.887e-194	617.0	COG0318@1|root,KOG1176@2759|Eukaryota,3AIZB@33154|Opisthokonta,3BXNQ@33208|Metazoa,3DFMP@33213|Bilateria,48SPA@7711|Chordata,49P71@7742|Vertebrata,3JP3T@40674|Mammalia,4J1NF@91561|Cetartiodactyla	33208|Metazoa	I	4-coumarate--CoA	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
SHD2_k127_6352745_106	1112216.JH594425_gene3141	2.502e-06	54.0	2C7HC@1|root,2ZEX5@2|Bacteria,1N7NS@1224|Proteobacteria,2UGBA@28211|Alphaproteobacteria,2K7T5@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_6352745_38	1280950.HJO_10124	8.157e-144	464.0	COG2070@1|root,COG2070@2|Bacteria,1MWPC@1224|Proteobacteria,2TQRT@28211|Alphaproteobacteria,43XYZ@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	COG2070 Dioxygenases related to 2-nitropropane dioxygenase	-	-	1.3.1.9	ko:K02371	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00083	R04429,R04724,R04955,R04958,R04961,R04966,R04969,R07765	RC00052,RC00076	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	NMO
SHD2_k127_6352745_60	402881.Plav_1019	6.485e-102	349.0	COG2211@1|root,COG2211@2|Bacteria,1MVUM@1224|Proteobacteria,2U5GA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	MFS/sugar transport protein	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
SHD2_k127_6352745_21	1038867.AXAY01000011_gene5369	5.871e-196	616.0	COG4030@1|root,COG4030@2|Bacteria,1NSDB@1224|Proteobacteria,2TSXU@28211|Alphaproteobacteria,3JXQR@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF2961)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2961
SHD2_k127_6352745_93	616991.JPOO01000001_gene2822	9.536e-26	121.0	COG5285@1|root,COG5285@2|Bacteria,4NK46@976|Bacteroidetes,1I10I@117743|Flavobacteriia,23G44@178469|Arenibacter	976|Bacteroidetes	Q	Phytanoyl-CoA dioxygenase (PhyH)	-	-	-	-	-	-	-	-	-	-	-	-	PhyH
SHD2_k127_6352745_69	439497.RR11_3556	4.61e-94	318.0	COG3618@1|root,COG3618@2|Bacteria,1P5PT@1224|Proteobacteria,2U3BR@28211|Alphaproteobacteria,4NBQZ@97050|Ruegeria	28211|Alphaproteobacteria	S	Amidohydrolase	-	-	-	ko:K07046	ko00051,ko01120,map00051,map01120	-	R10689	RC00537	ko00000,ko00001,ko01000	-	-	-	Amidohydro_2
SHD2_k127_6352745_73	1282876.BAOK01000001_gene1333	1.032e-61	220.0	COG2853@1|root,COG2853@2|Bacteria,1MVX0@1224|Proteobacteria,2U7CZ@28211|Alphaproteobacteria,4BQT3@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	M	MlaA lipoprotein	vacJ	-	-	ko:K04754	-	-	-	-	ko00000	-	-	-	MlaA
SHD2_k127_6352745_8	1123060.JONP01000003_gene498	2.699e-268	851.0	COG4258@1|root,COG4258@2|Bacteria,1QW57@1224|Proteobacteria,2TSFU@28211|Alphaproteobacteria,2JQW3@204441|Rhodospirillales	204441|Rhodospirillales	S	MMPL family	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
SHD2_k127_6352745_79	1112212.JH584235_gene3538	1.708e-43	168.0	COG2854@1|root,COG2854@2|Bacteria,1N275@1224|Proteobacteria,2UEQP@28211|Alphaproteobacteria,2K5F6@204457|Sphingomonadales	204457|Sphingomonadales	Q	hopanoid biosynthesis associated membrane protein HpnM	-	-	-	ko:K07323	ko02010,map02010	M00210	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27.3	-	-	MlaC
SHD2_k127_6352745_10	414684.RC1_0565	9.645e-265	828.0	COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,2TRDD@28211|Alphaproteobacteria,2JQ00@204441|Rhodospirillales	204441|Rhodospirillales	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
SHD2_k127_6352745_71	178901.AmDm5_0649	5.16e-90	306.0	COG0142@1|root,COG0142@2|Bacteria,1MWNG@1224|Proteobacteria,2TR79@28211|Alphaproteobacteria,2JQDQ@204441|Rhodospirillales	204441|Rhodospirillales	H	Belongs to the FPP GGPP synthase family	ispA	-	2.5.1.1,2.5.1.10	ko:K00795	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364	R01658,R02003	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
SHD2_k127_6352745_37	648757.Rvan_3014	1.284e-145	466.0	COG0761@1|root,COG0761@2|Bacteria,1MU7G@1224|Proteobacteria,2TRNR@28211|Alphaproteobacteria,3N7TQ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	-	LYTB
SHD2_k127_6352745_25	269482.Bcep1808_3717	6.284e-190	601.0	COG0535@1|root,COG0535@2|Bacteria,1MXM1@1224|Proteobacteria,2VNRX@28216|Betaproteobacteria,1K451@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Hopanoid biosynthesis associated radical SAM protein HpnH	hpnH	-	-	-	-	-	-	-	-	-	-	-	DUF3463,Fer4_14,Radical_SAM
SHD2_k127_6352745_86	1112214.AHIS01000063_gene2754	4.501e-36	148.0	COG0775@1|root,COG0775@2|Bacteria,1PETT@1224|Proteobacteria,2TTTB@28211|Alphaproteobacteria,2K573@204457|Sphingomonadales	204457|Sphingomonadales	F	PFAM purine or other phosphorylase family 1	-	-	-	-	-	-	-	-	-	-	-	-	PNP_UDP_1
SHD2_k127_6352745_5	1336208.JADY01000026_gene2293	5.734e-309	957.0	COG1657@1|root,COG1657@2|Bacteria,1MUIP@1224|Proteobacteria,2TRF3@28211|Alphaproteobacteria,2JQUI@204441|Rhodospirillales	204441|Rhodospirillales	I	Squalene-hopene cyclase C-terminal domain	-	-	4.2.1.129,5.4.99.17	ko:K06045	ko00909,ko01110,map00909,map01110	-	R07322,R07323	RC01850,RC01851	ko00000,ko00001,ko01000	-	-	-	SQHop_cyclase_C,SQHop_cyclase_N
SHD2_k127_6352745_33	1336208.JADY01000026_gene2294	8.573e-161	519.0	COG1233@1|root,COG1233@2|Bacteria,1QU52@1224|Proteobacteria,2TW02@28211|Alphaproteobacteria,2JYY3@204441|Rhodospirillales	204441|Rhodospirillales	Q	Flavin containing amine oxidoreductase	-	-	1.17.8.1	ko:K21677	-	-	-	-	ko00000,ko01000	-	-	-	Amino_oxidase
SHD2_k127_6352745_61	1054213.HMPREF9946_00168	1.63e-101	338.0	COG1562@1|root,COG1562@2|Bacteria,1MX4W@1224|Proteobacteria,2TTI0@28211|Alphaproteobacteria,2JRHF@204441|Rhodospirillales	204441|Rhodospirillales	I	Phytoene synthase	-	-	2.5.1.103	ko:K21678	-	-	-	-	ko00000,ko01000	-	-	-	SQS_PSY
SHD2_k127_6352745_66	685778.AORL01000022_gene1334	1.635e-95	332.0	COG1562@1|root,COG1562@2|Bacteria,1N6J2@1224|Proteobacteria,2TT8U@28211|Alphaproteobacteria,2K22E@204457|Sphingomonadales	204457|Sphingomonadales	I	Squalene/phytoene synthase	-	-	4.2.3.156	ko:K21679	-	-	-	-	ko00000,ko01000	-	-	-	SQS_PSY
SHD2_k127_6352745_36	1123060.JONP01000016_gene5438	4.586e-147	489.0	COG1215@1|root,COG1215@2|Bacteria,1MW1E@1224|Proteobacteria,2U30S@28211|Alphaproteobacteria,2JR6T@204441|Rhodospirillales	204441|Rhodospirillales	M	Glycosyl transferase family 21	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glycos_transf_2,SQS_PSY
SHD2_k127_6352745_44	266264.Rmet_4170	4.794e-131	433.0	COG0451@1|root,COG0451@2|Bacteria,1MW32@1224|Proteobacteria,2VIQ7@28216|Betaproteobacteria,1K2DE@119060|Burkholderiaceae	28216|Betaproteobacteria	M	PFAM NAD-dependent epimerase dehydratase	-	-	1.1.1.219	ko:K00091	-	-	-	-	ko00000,ko01000	-	-	-	Epimerase
SHD2_k127_6352745_54	1192124.LIG30_4476	3.129e-114	375.0	COG1633@1|root,COG1633@2|Bacteria,1QG5X@1224|Proteobacteria,2VPS9@28216|Betaproteobacteria,1K37Z@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_6352745_58	426355.Mrad2831_0972	1.158e-103	344.0	COG3394@1|root,COG3394@2|Bacteria,1PP39@1224|Proteobacteria,2U2UW@28211|Alphaproteobacteria,1JRFB@119045|Methylobacteriaceae	28211|Alphaproteobacteria	G	TIGRFAM hopanoid biosynthesis associated protein HpnK	-	-	3.5.1.105	ko:K03478	-	-	-	-	ko00000,ko01000	-	-	-	YdjC
SHD2_k127_6352745_9	670307.HYPDE_24913	1.77e-266	824.0	COG1032@1|root,COG1032@2|Bacteria,1MWR0@1224|Proteobacteria,2TRFJ@28211|Alphaproteobacteria,3N94V@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	hopanoid biosynthesis associated radical SAM protein HpnJ	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
SHD2_k127_6352745_63	670307.HYPDE_24918	4.556e-99	336.0	COG1215@1|root,COG1215@2|Bacteria,1Q6U2@1224|Proteobacteria,2VG3U@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Hopanoid biosynthesis associated glycosyl transferase protein HpnI	-	-	2.4.1.80	ko:K00720	ko00600,ko01100,map00600,map01100	M00066	R01497	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko02000	4.D.1.4	GT21	-	Glyco_transf_21
SHD2_k127_6352745_20	402881.Plav_3009	4.07e-196	615.0	COG1062@1|root,COG1062@2|Bacteria,1MUK4@1224|Proteobacteria,2TT67@28211|Alphaproteobacteria,1JN6J@119043|Rhodobiaceae	28211|Alphaproteobacteria	C	Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.1,1.1.1.284,1.1.1.90	ko:K00001,ko:K00055,ko:K00121	ko00010,ko00071,ko00350,ko00360,ko00622,ko00623,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00360,map00622,map00623,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204	M00537,M00538	R00623,R00754,R01763,R02124,R02611,R04304,R04805,R04880,R05233,R05234,R05282,R05347,R05348,R06917,R06927,R06983,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
SHD2_k127_6352745_53	1282876.BAOK01000001_gene3043	1.458e-116	380.0	COG1028@1|root,COG1028@2|Bacteria,1R6PG@1224|Proteobacteria,2U54K@28211|Alphaproteobacteria	28211|Alphaproteobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
SHD2_k127_6352745_47	402881.Plav_1685	3.86e-127	417.0	COG1024@1|root,COG1024@2|Bacteria,1MXHV@1224|Proteobacteria,2TTEG@28211|Alphaproteobacteria,1JQ8D@119043|Rhodobiaceae	28211|Alphaproteobacteria	I	Enoyl-CoA hydratase/isomerase	MA20_06735	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
SHD2_k127_6352745_11	402881.Plav_1446	1.416e-263	822.0	COG1012@1|root,COG1012@2|Bacteria,1MUHV@1224|Proteobacteria,2TSMD@28211|Alphaproteobacteria,1JNAI@119043|Rhodobiaceae	28211|Alphaproteobacteria	C	Aldehyde dehydrogenase family	mmsA	GO:0003674,GO:0005488,GO:0005507,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006950,GO:0006979,GO:0008150,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050896	1.2.1.18,1.2.1.27	ko:K00140	ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200	M00013	R00705,R00706,R00922,R00935	RC00004,RC02723,RC02817	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
SHD2_k127_6352745_48	1282876.BAOK01000001_gene1894	5.506e-126	414.0	COG1024@1|root,COG1024@2|Bacteria,1MU0B@1224|Proteobacteria,2TQW3@28211|Alphaproteobacteria,4BPY9@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	I	Enoyl-CoA hydratase/isomerase	hibch	-	3.1.2.4,4.2.1.17	ko:K01692,ko:K05605	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01200,map01212	M00013,M00032,M00087	R03026,R03045,R03158,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05064,R05595,R06411,R06412,R06942,R08093	RC00004,RC00014,RC00137,RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_2
SHD2_k127_6352745_52	1244869.H261_15707	1.517e-117	384.0	COG2084@1|root,COG2084@2|Bacteria,1RA7F@1224|Proteobacteria,2UVAZ@28211|Alphaproteobacteria,2JR0K@204441|Rhodospirillales	204441|Rhodospirillales	I	Belongs to the 3-hydroxyisobutyrate dehydrogenase family	mmsB	-	1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
SHD2_k127_6352745_1	402881.Plav_2961	0.0	1157.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TQMW@28211|Alphaproteobacteria,1JNHC@119043|Rhodobiaceae	28211|Alphaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	coxL	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
SHD2_k127_6352745_92	1122132.AQYH01000010_gene3745	1.676e-26	114.0	2BGF0@1|root,32ACV@2|Bacteria,1RI61@1224|Proteobacteria,2U9WW@28211|Alphaproteobacteria,4BHY9@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF3307)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3307
SHD2_k127_6352745_80	313606.M23134_03132	2.484e-41	170.0	COG0664@1|root,COG0668@1|root,COG0664@2|Bacteria,COG0668@2|Bacteria	2|Bacteria	M	transmembrane transport	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel,cNMP_binding
SHD2_k127_6352745_27	1380394.JADL01000001_gene2959	1.559e-185	602.0	COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,2VFBT@28211|Alphaproteobacteria,2JRT5@204441|Rhodospirillales	204441|Rhodospirillales	T	CHASE2	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc
SHD2_k127_6352745_76	1380394.JADL01000001_gene2958	1.36e-51	198.0	2BTDR@1|root,32NJT@2|Bacteria,1NKD1@1224|Proteobacteria,2VC50@28211|Alphaproteobacteria,2JXWD@204441|Rhodospirillales	204441|Rhodospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_6352745_12	1380394.JADL01000001_gene2957	2.946e-261	839.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,1MWRF@1224|Proteobacteria,2TS2A@28211|Alphaproteobacteria,2JT2W@204441|Rhodospirillales	204441|Rhodospirillales	K	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,TPR_10,TPR_12,TPR_4,TPR_7
SHD2_k127_6352745_34	1380394.JADL01000001_gene2955	3.099e-156	512.0	COG2831@1|root,COG2831@2|Bacteria,1MWEC@1224|Proteobacteria,2U04Z@28211|Alphaproteobacteria,2JT2T@204441|Rhodospirillales	204441|Rhodospirillales	U	Haemolysin secretion/activation protein ShlB/FhaC/HecB	-	-	-	-	-	-	-	-	-	-	-	-	POTRA_2,ShlB
SHD2_k127_6352745_39	266835.14026384	1.077e-136	469.0	COG1020@1|root,COG3319@1|root,COG1020@2|Bacteria,COG3319@2|Bacteria,1R8W8@1224|Proteobacteria,2TSV2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Thioesterase domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Thioesterase
SHD2_k127_6352745_82	450851.PHZ_c0100	9.824e-39	152.0	COG2050@1|root,COG2050@2|Bacteria,1PP3J@1224|Proteobacteria,2U5E4@28211|Alphaproteobacteria,2KHG9@204458|Caulobacterales	204458|Caulobacterales	Q	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
SHD2_k127_6352745_45	864069.MicloDRAFT_00008810	2.754e-129	430.0	COG2317@1|root,COG2317@2|Bacteria,1MW7T@1224|Proteobacteria,2TSMY@28211|Alphaproteobacteria,1JS04@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues	-	-	3.4.17.19	ko:K01299	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M32
SHD2_k127_6352745_42	1429916.X566_09575	2.391e-134	434.0	COG1028@1|root,COG1028@2|Bacteria,1QTUD@1224|Proteobacteria,2TWT3@28211|Alphaproteobacteria,3K6NW@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
SHD2_k127_6352745_14	794903.OPIT5_01440	1.85e-237	769.0	COG0383@1|root,COG0383@2|Bacteria	2|Bacteria	G	mannose metabolic process	-	-	3.2.1.24	ko:K01191	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04131	-	GH38	-	Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C
SHD2_k127_6352745_17	1292034.OR37_03590	3.022e-214	681.0	COG2015@1|root,COG2015@2|Bacteria,1MU82@1224|Proteobacteria,2TSM1@28211|Alphaproteobacteria,2KHTP@204458|Caulobacterales	204458|Caulobacterales	Q	Alkyl sulfatase dimerisation	-	-	-	-	-	-	-	-	-	-	-	-	Alkyl_sulf_C,Alkyl_sulf_dimr,Lactamase_B
SHD2_k127_6352745_30	381666.H16_B0914	5.371e-166	531.0	COG1804@1|root,COG1804@2|Bacteria,1MVY1@1224|Proteobacteria,2VKB0@28216|Betaproteobacteria,1K405@119060|Burkholderiaceae	28216|Betaproteobacteria	C	CoA-transferase family III	-	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
SHD2_k127_6352745_16	450851.PHZ_c3248	8.333e-215	671.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TQKE@28211|Alphaproteobacteria,2KF6Z@204458|Caulobacterales	204458|Caulobacterales	C	acyl-CoA dehydrogenase	-	-	1.3.8.7	ko:K00249,ko:K06446	ko00071,ko00280,ko00410,ko00640,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map00930,map01100,map01110,map01120,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754,R06943	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
SHD2_k127_6352745_65	450851.PHZ_c3249	3.467e-98	327.0	COG1024@1|root,COG1024@2|Bacteria,1MWGT@1224|Proteobacteria,2TV7F@28211|Alphaproteobacteria,2KIJZ@204458|Caulobacterales	204458|Caulobacterales	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
SHD2_k127_6352745_78	452662.SJA_C1-19680	9.637e-45	174.0	COG5285@1|root,COG5285@2|Bacteria,1NWIU@1224|Proteobacteria,2USKY@28211|Alphaproteobacteria,2KAGB@204457|Sphingomonadales	204457|Sphingomonadales	Q	Phytanoyl-CoA dioxygenase (PhyH)	-	-	-	-	-	-	-	-	-	-	-	-	PhyH
SHD2_k127_6352745_31	331869.BAL199_02434	5.379e-163	531.0	COG2303@1|root,COG2303@2|Bacteria,1N0NP@1224|Proteobacteria,2TQSK@28211|Alphaproteobacteria,4BRQ5@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	GMC oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N
SHD2_k127_6352745_91	258594.RPA3654	1.581e-31	134.0	COG0746@1|root,COG0746@2|Bacteria,1RH3M@1224|Proteobacteria,2TV2G@28211|Alphaproteobacteria,3JT8E@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	mobA	-	2.7.7.77	ko:K03752	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
SHD2_k127_6352745_4	671143.DAMO_1138	0.0	1079.0	COG3383@1|root,COG3383@2|Bacteria,2NNQ6@2323|unclassified Bacteria	2|Bacteria	C	Molydopterin dinucleotide binding domain	fdxB	-	1.17.1.10,1.17.1.9	ko:K00123,ko:K05299	ko00630,ko00680,ko00720,ko01100,ko01120,ko01200,map00630,map00680,map00720,map01100,map01120,map01200	M00377	R00134,R00519	RC02796	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_4,Fer4,Fer4_10,Fer4_4,Fer4_6,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding
SHD2_k127_6352745_59	1538295.JY96_17645	2.856e-103	340.0	COG5514@1|root,COG5514@2|Bacteria,1MX90@1224|Proteobacteria,2VIMN@28216|Betaproteobacteria,1KKIT@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Domain of unknown function (DUF1794)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1794
SHD2_k127_6352745_24	59538.XP_005973744.1	4.406e-193	611.0	COG2124@1|root,KOG0157@2759|Eukaryota,39TXH@33154|Opisthokonta	33154|Opisthokonta	Q	Cytochrome P450	-	-	1.7.1.14	ko:K15877	ko00910,ko01120,map00910,map01120	M00529	R02492,R09446,R09808,R09809	RC02794	ko00000,ko00001,ko00002,ko01000	-	-	-	p450
SHD2_k127_6352745_26	266117.Rxyl_3012	1.213e-185	589.0	COG4948@1|root,COG4948@2|Bacteria,2GKSK@201174|Actinobacteria,4CRMH@84995|Rubrobacteria	84995|Rubrobacteria	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	-	4.2.1.68	ko:K18334	ko00051,ko01120,map00051,map01120	-	R03688	RC00543	ko00000,ko00001,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
SHD2_k127_6352745_84	203275.BFO_2526	1.202e-37	145.0	COG3254@1|root,COG3254@2|Bacteria,4NQQ9@976|Bacteroidetes,2FTDQ@200643|Bacteroidia,22Z1W@171551|Porphyromonadaceae	976|Bacteroidetes	G	L-rhamnose mutarotase	-	-	5.1.3.32	ko:K03534	-	-	R10819	RC00563	ko00000,ko01000	-	-	-	rhaM
SHD2_k127_6352745_51	258594.RPA1579	1.63e-121	403.0	COG1804@1|root,COG1804@2|Bacteria,1MWPB@1224|Proteobacteria,2U1YE@28211|Alphaproteobacteria,3JS2K@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	CoA-transferase family III	MA20_04610	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
SHD2_k127_6352745_35	323097.Nham_1170	3.249e-150	485.0	COG3239@1|root,COG3239@2|Bacteria,1MY4I@1224|Proteobacteria,2TUF8@28211|Alphaproteobacteria,3JS8B@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	fatty acid desaturase	des	-	1.14.19.23,1.14.19.45	ko:K10255	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	-	FA_desaturase
SHD2_k127_6352745_6	1333998.M2A_2255	1.13e-285	881.0	COG2072@1|root,COG2072@2|Bacteria,1MU71@1224|Proteobacteria,2TV2E@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Flavoprotein involved in K transport	MA20_23085	-	-	-	-	-	-	-	-	-	-	-	FMO-like,K_oxygenase,NAD_binding_8,Pyr_redox_2
SHD2_k127_6352745_107	1528106.JRJE01000028_gene346	4.191e-06	61.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,2JQMP@204441|Rhodospirillales	204441|Rhodospirillales	OQ	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind
SHD2_k127_6352745_96	1211115.ALIQ01000194_gene233	2.126e-16	88.0	28I3D@1|root,2Z876@2|Bacteria,1P0DR@1224|Proteobacteria,2TTG2@28211|Alphaproteobacteria,3NCFF@45404|Beijerinckiaceae	28211|Alphaproteobacteria	S	PFAM type IV pilus assembly PilZ	MA20_31715	-	-	-	-	-	-	-	-	-	-	-	PilZ
SHD2_k127_6352745_97	266264.Rmet_1925	8.313e-16	87.0	COG3064@1|root,COG3064@2|Bacteria,1N4IA@1224|Proteobacteria,2VW11@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_6352745_104	665029.EAMY_2211	1.082e-08	59.0	COG1902@1|root,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,1RMII@1236|Gammaproteobacteria,3X4XV@551|Erwinia	1236|Gammaproteobacteria	C	NADH:flavin oxidoreductase / NADH oxidase family	xenA	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN
SHD2_k127_6352745_68	450851.PHZ_c2590	5.552e-95	318.0	COG1028@1|root,COG1028@2|Bacteria,1MUPX@1224|Proteobacteria,2TT6C@28211|Alphaproteobacteria,2KFEA@204458|Caulobacterales	204458|Caulobacterales	IQ	short-chain dehydrogenase	-	-	1.1.1.51	ko:K05296	ko00140,ko00984,ko01100,ko01120,map00140,map00984,map01100,map01120	-	R01836,R01838,R02352,R02353,R03406,R03407,R09956,R09957	RC00127,RC00144	ko00000,ko00001,ko01000	-	-	-	adh_short_C2
SHD2_k127_6352745_67	1174684.EBMC1_14610	3.663e-95	317.0	COG0625@1|root,COG0625@2|Bacteria,1MUN3@1224|Proteobacteria,2TTVR@28211|Alphaproteobacteria,2KCX1@204457|Sphingomonadales	204457|Sphingomonadales	O	Belongs to the GST superfamily	-	-	-	ko:K11209	-	-	-	-	ko00000,ko01000	-	-	-	GST_C,GST_C_3,GST_N,GST_N_3
SHD2_k127_6352745_28	1248760.ANFZ01000014_gene2180	2.186e-184	585.0	COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,2TU8Q@28211|Alphaproteobacteria,2K63F@204457|Sphingomonadales	204457|Sphingomonadales	H	Aminotransferase class-III	-	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
SHD2_k127_6352745_62	1197906.CAJQ02000015_gene308	1.333e-100	335.0	COG0346@1|root,COG0346@2|Bacteria,1R9XW@1224|Proteobacteria,2U6IT@28211|Alphaproteobacteria,3K3B6@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase_4
SHD2_k127_6352745_46	247633.GP2143_12221	2.179e-127	411.0	COG4221@1|root,COG4221@2|Bacteria,1MW86@1224|Proteobacteria,1SMC5@1236|Gammaproteobacteria,1J7M9@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
SHD2_k127_6352745_90	366602.Caul_1934	2.661e-33	138.0	COG0589@1|root,COG0589@2|Bacteria,1NDDA@1224|Proteobacteria	1224|Proteobacteria	T	Belongs to the universal stress protein A family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
SHD2_k127_6352745_15	450851.PHZ_c0733	9.421e-218	687.0	COG0318@1|root,COG0318@2|Bacteria,1MUIC@1224|Proteobacteria,2TRRZ@28211|Alphaproteobacteria,2KHWY@204458|Caulobacterales	204458|Caulobacterales	IQ	AMP-binding enzyme C-terminal domain	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
SHD2_k127_6352745_13	402881.Plav_0092	3.835e-252	782.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	belongs to the aldehyde dehydrogenase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldedh
SHD2_k127_6352745_29	402881.Plav_0089	3.402e-180	569.0	COG1062@1|root,COG1062@2|Bacteria,1MUK4@1224|Proteobacteria,2V8RZ@28211|Alphaproteobacteria,1JPNM@119043|Rhodobiaceae	28211|Alphaproteobacteria	C	Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.90	ko:K00055	ko00350,ko00360,ko00622,ko00623,ko01100,ko01120,ko01220,map00350,map00360,map00622,map00623,map01100,map01120,map01220	M00537,M00538	R01763,R02611,R04304,R05282,R05347,R05348	RC00087,RC00116	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
SHD2_k127_6352745_19	1297865.APJD01000002_gene4113	1.063e-202	634.0	2DB8I@1|root,2Z7RY@2|Bacteria,1MY4M@1224|Proteobacteria,2U2A8@28211|Alphaproteobacteria,3JTM4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_6352745_101	666684.AfiDRAFT_0861	1.59e-11	68.0	COG2199@1|root,COG3706@2|Bacteria,1NAVK@1224|Proteobacteria,2UF4H@28211|Alphaproteobacteria,3K0YM@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	PilZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PilZ
SHD2_k127_6352745_41	228405.HNE_1900	2.976e-135	444.0	COG3552@1|root,COG3552@2|Bacteria,1MUHH@1224|Proteobacteria,2U05M@28211|Alphaproteobacteria,43ZK8@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	COG3552 Protein containing von Willebrand factor type A (vWA) domain	MA20_34745	-	-	ko:K07161	-	-	-	-	ko00000	-	-	-	VWA_CoxE
SHD2_k127_6352745_43	1280950.HJO_05580	7.986e-134	437.0	COG0714@1|root,COG0714@2|Bacteria,1MV5I@1224|Proteobacteria,2TREB@28211|Alphaproteobacteria,43ZA3@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	AAA ATPase	MA20_34740	-	-	-	-	-	-	-	-	-	-	-	AAA_5
SHD2_k127_6352745_88	1236902.ANAS01000001_gene1968	2.671e-34	142.0	COG2267@1|root,COG2267@2|Bacteria,2I0NW@201174|Actinobacteria	201174|Actinobacteria	I	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4
SHD2_k127_6352745_81	288000.BBta_2182	4.482e-39	152.0	2DM0Y@1|root,318KY@2|Bacteria,1NM1E@1224|Proteobacteria,2UVRR@28211|Alphaproteobacteria,3K4TZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DUF1992)	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_6352745_18	288000.BBta_2746	6.177e-211	665.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TS1R@28211|Alphaproteobacteria,3JV4N@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Belongs to the thiolase family	MA20_45145	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
SHD2_k127_6352745_105	670487.Ocepr_2228	4.684e-08	57.0	COG0500@1|root,COG1266@1|root,COG1266@2|Bacteria,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Abi,Methyltransf_11,Methyltransf_23,Methyltransf_25
SHD2_k127_6352745_85	1449065.JMLL01000011_gene2066	1.212e-37	147.0	COG3467@1|root,COG3467@2|Bacteria,1NMEU@1224|Proteobacteria,2USRA@28211|Alphaproteobacteria,43KB7@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Pyridox_ox_2
SHD2_k127_6352745_102	1123355.JHYO01000074_gene89	1.321e-10	67.0	2DRMU@1|root,33CBD@2|Bacteria,1NAJE@1224|Proteobacteria,2UG63@28211|Alphaproteobacteria,37127@31993|Methylocystaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_6352745_40	648885.KB316282_gene1755	9.776e-136	447.0	COG3920@1|root,COG3920@2|Bacteria,1R720@1224|Proteobacteria,2V7IA@28211|Alphaproteobacteria,1JX1S@119045|Methylobacteriaceae	28211|Alphaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_2,PAS_4
SHD2_k127_6352745_95	366602.Caul_0719	2.165e-23	107.0	COG0784@1|root,COG0784@2|Bacteria,1NYX2@1224|Proteobacteria,2UTDN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	'PFAM Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
SHD2_k127_6352745_75	1479238.JQMZ01000001_gene250	2.293e-53	196.0	COG1595@1|root,COG1595@2|Bacteria,1MZMC@1224|Proteobacteria,2TUUZ@28211|Alphaproteobacteria,43W7Y@69657|Hyphomonadaceae	28211|Alphaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
SHD2_k127_6352745_103	1382303.JPOM01000001_gene149	5.736e-09	60.0	2DSDV@1|root,33FQ3@2|Bacteria,1NGE8@1224|Proteobacteria,2UKRI@28211|Alphaproteobacteria,2KHF0@204458|Caulobacterales	204458|Caulobacterales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_6352745_72	1161401.ASJA01000008_gene1610	4.549e-79	272.0	COG0784@1|root,COG0784@2|Bacteria,1MX3Y@1224|Proteobacteria,2TT2R@28211|Alphaproteobacteria,43WD0@69657|Hyphomonadaceae	28211|Alphaproteobacteria	T	response regulator	phyR	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Sigma70_r4_2
SHD2_k127_6352745_83	1205680.CAKO01000030_gene4866	1.523e-38	151.0	2CPI3@1|root,32SJ7@2|Bacteria,1N1IR@1224|Proteobacteria,2UBVS@28211|Alphaproteobacteria,2JX60@204441|Rhodospirillales	204441|Rhodospirillales	S	Protein of unknown function (DUF992)	-	-	-	-	-	-	-	-	-	-	-	-	DUF992
SHD2_k127_6352745_94	648757.Rvan_2356	6.149e-24	109.0	COG4520@1|root,COG4520@2|Bacteria,1N0YF@1224|Proteobacteria,2UA8D@28211|Alphaproteobacteria,3N7G9@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Glycine zipper 2TM domain	omp	-	-	-	-	-	-	-	-	-	-	-	17kDa_Anti_2,Gly-zipper_Omp,Rick_17kDa_Anti
SHD2_k127_6352745_0	1131814.JAFO01000001_gene3315	0.0	3193.0	COG3459@1|root,COG3459@2|Bacteria,1MVNX@1224|Proteobacteria,2TSAJ@28211|Alphaproteobacteria,3EYBF@335928|Xanthobacteraceae	28211|Alphaproteobacteria	G	Glycosyl hydrolase 36 superfamily, catalytic domain	ndvB	GO:0003674,GO:0003824,GO:0016740,GO:0016757	2.4.1.321	ko:K13688,ko:K18786	-	-	R10832	RC00397	ko00000,ko01000,ko01003	-	GH94,GT84	-	Glyco_hydro_36,Glyco_transf_36,Glycoamylase
SHD2_k127_6352745_32	1333998.M2A_1436	9.987e-162	517.0	COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,2TSD0@28211|Alphaproteobacteria,4BSFY@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	G	Phosphofructokinase	pfkA	-	2.7.1.11,2.7.1.90	ko:K00850,ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R00764,R02073,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
SHD2_k127_6352745_77	1161401.ASJA01000008_gene1608	3.616e-51	190.0	COG1595@1|root,COG1595@2|Bacteria,1MZMC@1224|Proteobacteria,2TUUZ@28211|Alphaproteobacteria,43W7Y@69657|Hyphomonadaceae	28211|Alphaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
SHD2_k127_6352745_108	1121859.KB890750_gene328	3.012e-05	50.0	COG2885@1|root,COG2885@2|Bacteria,4NEGF@976|Bacteroidetes	976|Bacteroidetes	M	Belongs to the ompA family	yiaD	-	-	-	-	-	-	-	-	-	-	-	Gly-zipper_Omp,OmpA
SHD2_k127_6352745_98	1163408.UU9_14165	3.001e-14	78.0	2EGHT@1|root,33A9W@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_6352745_56	450851.PHZ_c2561	1.109e-107	351.0	COG2070@1|root,COG2070@2|Bacteria,1P5WC@1224|Proteobacteria,2U490@28211|Alphaproteobacteria,2KIAF@204458|Caulobacterales	204458|Caulobacterales	S	Nitronate monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	NMO
SHD2_k127_637112_2	1185652.USDA257_c04030	8.973e-16	83.0	2APHI@1|root,31EKI@2|Bacteria,1P69T@1224|Proteobacteria,2UWB5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_637112_0	582899.Hden_0709	1.959e-246	763.0	COG5659@1|root,COG5659@2|Bacteria,1MWAV@1224|Proteobacteria,2U2Q3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5,DDE_Tnp_1
SHD2_k127_637112_1	384765.SIAM614_02521	2.06e-96	321.0	COG2801@1|root,COG2801@2|Bacteria,1MWNX@1224|Proteobacteria,2TZ7M@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	LZ_Tnp_IS481,rve,rve_3
SHD2_k127_6382739_3	314271.RB2654_06599	4.487e-25	107.0	COG2350@1|root,COG2350@2|Bacteria,1N0W9@1224|Proteobacteria,2U9T8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	YCII-related domain	-	-	-	ko:K09780	-	-	-	-	ko00000	-	-	-	YCII
SHD2_k127_6382739_2	1038859.AXAU01000002_gene312	1.945e-78	276.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2U0WM@28211|Alphaproteobacteria,3JVFM@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
SHD2_k127_6382739_1	935261.JAGL01000006_gene2290	2.847e-138	444.0	COG1024@1|root,COG1024@2|Bacteria,1MVB1@1224|Proteobacteria,2TVK3@28211|Alphaproteobacteria,43P70@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	4.1.2.41,4.2.1.101	ko:K18383	ko00360,ko01100,ko01110,map00360,map01100,map01110	-	R05772,R05773	RC00307,RC01468,RC01828	ko00000,ko00001,ko01000	-	-	-	ECH_1
SHD2_k127_6382739_0	1545915.JROG01000007_gene3283	2.719e-213	683.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,2TR24@28211|Alphaproteobacteria,2K1V7@204457|Sphingomonadales	204457|Sphingomonadales	C	CoA binding domain	ferA	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
SHD2_k127_6382739_4	1028801.RG1141_PA01010	4.076e-23	102.0	COG1846@1|root,COG1846@2|Bacteria,1N150@1224|Proteobacteria,2UIX8@28211|Alphaproteobacteria,4BDP1@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
SHD2_k127_6400575_83	1550073.JROH01000028_gene906	6.342e-19	99.0	COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,2TT3Z@28211|Alphaproteobacteria,2K2A0@204457|Sphingomonadales	204457|Sphingomonadales	M	membrane	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
SHD2_k127_6400575_16	402881.Plav_2018	5.657e-182	578.0	COG1960@1|root,COG1960@2|Bacteria,1MVJC@1224|Proteobacteria,2TQRA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	acyl-CoA dehydrogenase	MA20_04655	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
SHD2_k127_6400575_34	1280953.HOC_00895	4.156e-130	419.0	COG1028@1|root,COG1028@2|Bacteria,1RCD3@1224|Proteobacteria,2U67G@28211|Alphaproteobacteria,43ZBG@69657|Hyphomonadaceae	28211|Alphaproteobacteria	IQ	KR domain	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
SHD2_k127_6400575_29	402881.Plav_0370	4.404e-139	452.0	COG3173@1|root,COG3173@2|Bacteria,1MWAK@1224|Proteobacteria,2TT2N@28211|Alphaproteobacteria,1JN17@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	PFAM aminoglycoside phosphotransferase	-	-	-	-	-	-	-	-	-	-	-	-	APH
SHD2_k127_6400575_61	1121949.AQXT01000002_gene2480	1.91e-72	259.0	COG5285@1|root,COG5285@2|Bacteria,1PF68@1224|Proteobacteria,2UTIY@28211|Alphaproteobacteria,4406Q@69657|Hyphomonadaceae	28211|Alphaproteobacteria	Q	Phytanoyl-CoA dioxygenase (PhyH)	-	-	-	-	-	-	-	-	-	-	-	-	PhyH
SHD2_k127_6400575_30	1333998.M2A_1476	1.208e-138	456.0	COG3173@1|root,COG3173@2|Bacteria,1MWAK@1224|Proteobacteria,2TT2N@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Aminoglycoside phosphotransferase	-	-	-	-	-	-	-	-	-	-	-	-	APH
SHD2_k127_6400575_36	402881.Plav_0731	1.451e-121	395.0	COG4221@1|root,COG4221@2|Bacteria,1R83E@1224|Proteobacteria,2TVY6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
SHD2_k127_6400575_51	1502724.FF80_00104	3.313e-85	286.0	COG0512@1|root,COG0512@2|Bacteria,1MV5Y@1224|Proteobacteria,2TU3N@28211|Alphaproteobacteria,3N6Q1@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	EH	Anthranilate synthase	trpG	-	2.6.1.85,4.1.3.27	ko:K01658,ko:K01664	ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986,R01716	RC00010,RC01418,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
SHD2_k127_6400575_43	316056.RPC_2467	1.245e-107	360.0	COG0547@1|root,COG0547@2|Bacteria,1MUPV@1224|Proteobacteria,2TR8S@28211|Alphaproteobacteria,3JVIJ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.18,4.1.3.27	ko:K00766,ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R00985,R00986,R01073	RC00010,RC00440,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
SHD2_k127_6400575_47	582899.Hden_1441	6.367e-95	320.0	COG0134@1|root,COG0134@2|Bacteria,1MW5K@1224|Proteobacteria,2TSZE@28211|Alphaproteobacteria,3N64B@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Belongs to the TrpC family	trpC	GO:0003674,GO:0003824,GO:0004425,GO:0016829,GO:0016830,GO:0016831	4.1.1.48,5.3.1.24	ko:K01609,ko:K13498	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508,R03509	RC00944,RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS
SHD2_k127_6400575_75	717785.HYPMC_1586	4.709e-50	187.0	COG0315@1|root,COG0315@2|Bacteria,1RCYZ@1224|Proteobacteria,2U747@28211|Alphaproteobacteria,3N6ZS@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
SHD2_k127_6400575_37	1121106.JQKB01000022_gene3754	1.381e-120	399.0	COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,2TQRI@28211|Alphaproteobacteria,2JPHJ@204441|Rhodospirillales	204441|Rhodospirillales	H	MoeA N-terminal region (domain I and II)	moeA	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
SHD2_k127_6400575_49	1079460.ATTQ01000007_gene3745	3.506e-88	298.0	COG1974@1|root,COG1974@2|Bacteria,1MW80@1224|Proteobacteria,2TT7W@28211|Alphaproteobacteria,4BAEU@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0009991,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031668,GO:0032991,GO:0032993,GO:0033554,GO:0043565,GO:0044212,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0071496,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
SHD2_k127_6400575_26	1238182.C882_4144	3.73e-149	498.0	COG0658@1|root,COG0658@2|Bacteria,1MUKF@1224|Proteobacteria,2TRD5@28211|Alphaproteobacteria,2JR1J@204441|Rhodospirillales	204441|Rhodospirillales	S	Competence protein	-	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131
SHD2_k127_6400575_15	1131814.JAFO01000001_gene2365	1.861e-191	612.0	COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,2TRSU@28211|Alphaproteobacteria,3EYWP@335928|Xanthobacteraceae	28211|Alphaproteobacteria	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
SHD2_k127_6400575_11	648757.Rvan_3206	3.952e-222	696.0	COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,2TS63@28211|Alphaproteobacteria,3N6EI@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Belongs to the citrate synthase family	gltA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
SHD2_k127_6400575_45	414684.RC1_1194	1.843e-100	340.0	COG0763@1|root,COG0763@2|Bacteria,1MVBI@1224|Proteobacteria,2TSEA@28211|Alphaproteobacteria,2JQPI@204441|Rhodospirillales	204441|Rhodospirillales	M	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxB	-	2.4.1.182	ko:K00748	ko00540,ko01100,map00540,map01100	M00060	R04606	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT19	-	LpxB
SHD2_k127_6400575_62	1280948.HY36_10835	3.03e-72	253.0	COG3494@1|root,COG3494@2|Bacteria,1MWTH@1224|Proteobacteria,2U4AB@28211|Alphaproteobacteria,43XDW@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	protein conserved in bacteria	cdsA2	GO:0003674,GO:0003824,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008758,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	-	ko:K09949	-	-	-	-	ko00000	-	-	-	DUF1009
SHD2_k127_6400575_60	59538.XP_005968347.1	4.855e-76	264.0	COG1043@1|root,2QRGY@2759|Eukaryota,3A2QI@33154|Opisthokonta,3CQTC@33208|Metazoa,3E74W@33213|Bilateria	33208|Metazoa	M	Udp N-acetylglucosamine O-acyltransferase; Domain 2	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_11,Hexapep
SHD2_k127_6400575_77	1381123.AYOD01000001_gene962	2.658e-43	163.0	COG0764@1|root,COG0764@2|Bacteria,1RH2T@1224|Proteobacteria,2U7G4@28211|Alphaproteobacteria,43JNF@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	I	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs	fabZ	-	4.2.1.59	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
SHD2_k127_6400575_53	717785.HYPMC_2863	1.171e-83	289.0	COG1044@1|root,COG1044@2|Bacteria,1MUX6@1224|Proteobacteria,2TS8U@28211|Alphaproteobacteria,3N6MI@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxD	-	2.3.1.191	ko:K02536	ko00540,ko01100,map00540,map01100	M00060	R04550	RC00039,RC00166	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hexapep,Hexapep_2,LpxD
SHD2_k127_6400575_85	1220535.IMCC14465_00420	4.435e-11	72.0	COG2825@1|root,COG2825@2|Bacteria	2|Bacteria	M	unfolded protein binding	ompH	-	-	ko:K06142	-	-	-	-	ko00000	-	-	-	OmpH
SHD2_k127_6400575_7	1161401.ASJA01000007_gene2085	9.981e-236	753.0	COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,2TR7W@28211|Alphaproteobacteria,43W6E@69657|Hyphomonadaceae	28211|Alphaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamA	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
SHD2_k127_6400575_42	1333998.M2A_1034	6.104e-109	364.0	COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,2TQXJ@28211|Alphaproteobacteria,4BPIY@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	M	zinc metalloprotease	rseP	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_M50
SHD2_k127_6400575_32	1150469.RSPPHO_00151	4.625e-131	431.0	COG0743@1|root,COG0743@2|Bacteria,1MU4G@1224|Proteobacteria,2TSD1@28211|Alphaproteobacteria,2JQ6Y@204441|Rhodospirillales	204441|Rhodospirillales	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	-	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	-	DXPR_C,DXP_redisom_C,DXP_reductoisom
SHD2_k127_6400575_81	1150626.PHAMO_220014	5.417e-36	148.0	COG0575@1|root,COG0575@2|Bacteria,1MWSV@1224|Proteobacteria,2U9ED@28211|Alphaproteobacteria,2JSSK@204441|Rhodospirillales	204441|Rhodospirillales	I	Belongs to the CDS family	cdsA	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
SHD2_k127_6400575_52	861208.AGROH133_05873	3.349e-84	285.0	COG0020@1|root,COG0020@2|Bacteria,1MVP1@1224|Proteobacteria,2TTVJ@28211|Alphaproteobacteria,4B86U@82115|Rhizobiaceae	28211|Alphaproteobacteria	I	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS	GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
SHD2_k127_6400575_64	1122137.AQXF01000002_gene137	1.156e-68	239.0	COG0233@1|root,COG0233@2|Bacteria,1N66T@1224|Proteobacteria,2U5B2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	GO:0002181,GO:0002184,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
SHD2_k127_6400575_41	402881.Plav_3194	9.258e-110	359.0	COG0528@1|root,COG0528@2|Bacteria,1MV3N@1224|Proteobacteria,2TQYN@28211|Alphaproteobacteria,1JNTF@119043|Rhodobiaceae	28211|Alphaproteobacteria	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
SHD2_k127_6400575_40	1333998.M2A_1040	8.167e-112	368.0	COG0264@1|root,COG0264@2|Bacteria,1MUS2@1224|Proteobacteria,2TQM0@28211|Alphaproteobacteria,4BPJR@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
SHD2_k127_6400575_38	1161401.ASJA01000007_gene2077	1.212e-115	377.0	COG0052@1|root,COG0052@2|Bacteria,1MU33@1224|Proteobacteria,2TRXE@28211|Alphaproteobacteria,43WIG@69657|Hyphomonadaceae	28211|Alphaproteobacteria	J	Belongs to the universal ribosomal protein uS2 family	rpsB	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
SHD2_k127_6400575_39	1205680.CAKO01000007_gene4305	1.745e-113	379.0	COG0436@1|root,COG0436@2|Bacteria,1MX6F@1224|Proteobacteria,2TTAA@28211|Alphaproteobacteria,2JRA3@204441|Rhodospirillales	204441|Rhodospirillales	E	Aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
SHD2_k127_6400575_19	1280953.HOC_02291	5.035e-174	574.0	COG2091@1|root,COG2091@2|Bacteria,1MY8E@1224|Proteobacteria,2V4NX@28211|Alphaproteobacteria,43YZT@69657|Hyphomonadaceae	28211|Alphaproteobacteria	H	Carbohydrate family 9 binding domain-like	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
SHD2_k127_6400575_0	402881.Plav_3197	0.0	1260.0	COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,2TSCN@28211|Alphaproteobacteria,1JN3I@119043|Rhodobiaceae	28211|Alphaproteobacteria	L	DNA polymerase alpha chain like domain	dnaE	GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
SHD2_k127_6400575_69	1122963.AUHB01000013_gene4664	6.478e-60	218.0	COG0583@1|root,COG0583@2|Bacteria,1N663@1224|Proteobacteria,2TRAK@28211|Alphaproteobacteria,36YHG@31993|Methylocystaceae	28211|Alphaproteobacteria	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
SHD2_k127_6400575_84	1042377.AFPJ01000054_gene1695	6.971e-12	75.0	2C5U9@1|root,2Z9NJ@2|Bacteria,1R6D0@1224|Proteobacteria,1SAQZ@1236|Gammaproteobacteria,46861@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Bacterial protein of unknown function (Gcw_chp)	-	-	-	-	-	-	-	-	-	-	-	-	Gcw_chp
SHD2_k127_6400575_55	1101192.KB910516_gene3905	3.356e-82	280.0	COG1136@1|root,COG1136@2|Bacteria,1MVSQ@1224|Proteobacteria,2TSBE@28211|Alphaproteobacteria,1JQX1@119045|Methylobacteriaceae	28211|Alphaproteobacteria	V	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner	lolD	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006807,GO:0006810,GO:0008104,GO:0008150,GO:0008152,GO:0015031,GO:0015399,GO:0015405,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0022804,GO:0022857,GO:0031224,GO:0032991,GO:0033036,GO:0042157,GO:0042160,GO:0042623,GO:0042626,GO:0042886,GO:0042953,GO:0043170,GO:0043190,GO:0043492,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0044872,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1901564,GO:1902494,GO:1902495,GO:1904949,GO:1990351	-	ko:K09810	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.125	-	-	ABC_tran
SHD2_k127_6400575_23	1282876.BAOK01000001_gene2221	2.827e-154	499.0	COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,2TRBX@28211|Alphaproteobacteria,4BPKM@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	M	lipoprotein releasing system, transmembrane protein, LolC E family	lolC	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
SHD2_k127_6400575_5	648757.Rvan_3540	7.197e-254	796.0	COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,2TQQ4@28211|Alphaproteobacteria,3N7Q2@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro)	proS	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b
SHD2_k127_6400575_87	1161401.ASJA01000007_gene2071	3.04e-09	61.0	COG5454@1|root,COG5454@2|Bacteria,1NGEG@1224|Proteobacteria,2UJHR@28211|Alphaproteobacteria,43YUS@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1467)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1467
SHD2_k127_6400575_66	1333998.M2A_1052	2.905e-68	233.0	COG0346@1|root,COG0346@2|Bacteria,1RCYU@1224|Proteobacteria,2U728@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	methylmalonyl-CoA epimerase	mce	-	5.1.99.1	ko:K05606	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R02765,R09979	RC00780,RC02739	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase_4
SHD2_k127_6400575_14	1333998.M2A_1053	2.652e-199	638.0	COG0595@1|root,COG0595@2|Bacteria,1MUGV@1224|Proteobacteria,2TQTR@28211|Alphaproteobacteria,4BPAT@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Metallo-beta-lactamase superfamily	rnjA	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,Lactamase_B_2,RMMBL
SHD2_k127_6400575_44	1244869.H261_11194	1.63e-102	339.0	COG1521@1|root,COG1521@2|Bacteria,1MUYA@1224|Proteobacteria,2TS5A@28211|Alphaproteobacteria,2JPNZ@204441|Rhodospirillales	204441|Rhodospirillales	F	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis	coaX	-	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Pan_kinase
SHD2_k127_6400575_67	1333998.M2A_1054	5.029e-68	250.0	COG0340@1|root,COG0340@2|Bacteria,1MWCC@1224|Proteobacteria,2TS82@28211|Alphaproteobacteria,4BQJ1@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	H	Biotin/lipoate A/B protein ligase family	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB,BPL_LplA_LipB_2
SHD2_k127_6400575_22	1333998.M2A_1055	1.162e-154	510.0	COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,2TQMX@28211|Alphaproteobacteria,4BPBD@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
SHD2_k127_6400575_8	1282876.BAOK01000001_gene2232	2.322e-234	736.0	COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,2TSNK@28211|Alphaproteobacteria,4BPCM@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M	nuoM	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q5_N,Proton_antipo_M
SHD2_k127_6400575_4	1333998.M2A_1057	8.202e-267	836.0	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,2TQSS@28211|Alphaproteobacteria,4BPGG@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	CP	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus	nuoL	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADH5_C,Proton_antipo_M,Proton_antipo_N
SHD2_k127_6400575_78	1380394.JADL01000005_gene5391	8.662e-43	164.0	COG0713@1|root,COG0713@2|Bacteria,1RH0S@1224|Proteobacteria,2U93P@28211|Alphaproteobacteria,2JSRV@204441|Rhodospirillales	204441|Rhodospirillales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK	-	1.6.5.3	ko:K00340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
SHD2_k127_6400575_65	1429916.X566_21610	1.813e-68	237.0	COG0839@1|root,COG0839@2|Bacteria,1MWJV@1224|Proteobacteria,2TRB2@28211|Alphaproteobacteria,3K3BN@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	NADH-ubiquinone/plastoquinone oxidoreductase chain 6	nuoJ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
SHD2_k127_6400575_50	1161401.ASJA01000007_gene2061	5.73e-87	290.0	COG1143@1|root,COG1143@2|Bacteria,1MV90@1224|Proteobacteria,2TRFE@28211|Alphaproteobacteria,43WF3@69657|Hyphomonadaceae	28211|Alphaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoI	GO:0003674,GO:0003824,GO:0003954,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114	1.6.5.3,1.6.99.3	ko:K00338,ko:K03941	ko00190,ko01100,ko04714,ko04723,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04714,map04723,map04932,map05010,map05012,map05016	M00143,M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1,3.D.1.6	-	-	Fer4
SHD2_k127_6400575_28	1125973.JNLC01000017_gene3527	1.98e-140	453.0	COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,2TS09@28211|Alphaproteobacteria,3JRWX@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	GO:0003674,GO:0003824,GO:0003954,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
SHD2_k127_6400575_3	1120983.KB894570_gene1807	3.338e-280	882.0	COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,2TS97@28211|Alphaproteobacteria,1JNPV@119043|Rhodobiaceae	28211|Alphaproteobacteria	C	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region	nuoG	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdopterin,NADH-G_4Fe-4S_3,NADH_dhqG_C
SHD2_k127_6400575_58	314260.PB2503_02192	1.177e-76	258.0	COG2329@1|root,COG2329@2|Bacteria,1RAC6@1224|Proteobacteria,2U59M@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Domain of unknown function (DUF3291)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3291
SHD2_k127_6400575_10	1144343.PMI41_02534	1.043e-224	704.0	COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,2TRAH@28211|Alphaproteobacteria,43HX9@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	nuoF	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
SHD2_k127_6400575_68	1510531.JQJJ01000011_gene2823	8.865e-67	235.0	COG1905@1|root,COG3743@1|root,COG1905@2|Bacteria,COG3743@2|Bacteria,1MWS2@1224|Proteobacteria,2TSEJ@28211|Alphaproteobacteria,3JU8S@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Thioredoxin-like [2Fe-2S] ferredoxin	nuoE	-	1.6.5.3,1.6.99.3	ko:K00334,ko:K03943	ko00190,ko01100,ko04714,ko04723,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04714,map04723,map04932,map05010,map05012,map05016	M00143,M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1,3.D.1.6	-	-	2Fe-2S_thioredx
SHD2_k127_6400575_13	1333998.M2A_1065	2.249e-215	679.0	COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,2TQZ0@28211|Alphaproteobacteria,4BPED@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	GO:0003674,GO:0003824,GO:0003954,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
SHD2_k127_6400575_54	1333998.M2A_1066	1.111e-82	282.0	COG0852@1|root,COG0852@2|Bacteria,1MX4B@1224|Proteobacteria,2TSMT@28211|Alphaproteobacteria,4BQ2X@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	GO:0003674,GO:0003824,GO:0003954,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
SHD2_k127_6400575_46	670307.HYPDE_28828	3.532e-99	325.0	COG0377@1|root,COG0377@2|Bacteria,1MUI2@1224|Proteobacteria,2TQK3@28211|Alphaproteobacteria,3N6IK@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoB	GO:0003674,GO:0003824,GO:0003954,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
SHD2_k127_6400575_72	1282876.BAOK01000001_gene2244	6.03e-55	195.0	COG0838@1|root,COG0838@2|Bacteria,1RGUT@1224|Proteobacteria,2U72Q@28211|Alphaproteobacteria,4BQBD@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
SHD2_k127_6400575_90	264402.Cagra.3706s0016.1.p	4.993e-06	55.0	COG5126@1|root,KOG0027@2759|Eukaryota,37RPE@33090|Viridiplantae,3GCTJ@35493|Streptophyta,3HMJJ@3699|Brassicales	35493|Streptophyta	T	MSS3 MSS3 (multicopy suppressors of snf4 deficiency in yeast 3)	-	GO:0003674,GO:0005488,GO:0005509,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005768,GO:0010008,GO:0012505,GO:0016020,GO:0016021,GO:0031090,GO:0031224,GO:0031300,GO:0031301,GO:0031302,GO:0031303,GO:0031410,GO:0031982,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0044422,GO:0044424,GO:0044425,GO:0044433,GO:0044440,GO:0044444,GO:0044446,GO:0044464,GO:0046872,GO:0097708,GO:0098588,GO:0098805	-	ko:K13448	ko04626,map04626	-	-	-	ko00000,ko00001	-	-	-	EF-hand_1,EF-hand_5
SHD2_k127_6400575_88	1207063.P24_15991	1.839e-08	64.0	COG5126@1|root,COG5126@2|Bacteria	2|Bacteria	DTZ	Ca2 -binding protein (EF-Hand superfamily	cabB	-	-	-	-	-	-	-	-	-	-	-	EF-hand_1,EF-hand_5,EF-hand_7,EF-hand_8
SHD2_k127_6400575_27	479432.Sros_0733	2.584e-147	474.0	COG0462@1|root,COG0462@2|Bacteria,2GKR2@201174|Actinobacteria,4EGRM@85012|Streptosporangiales	201174|Actinobacteria	EF	Phosphoribosyl synthetase-associated domain	prs_1	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
SHD2_k127_6400575_89	1382306.JNIM01000001_gene239	1.827e-07	59.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	ysfE	-	2.7.1.49,2.7.4.7,4.2.1.96,4.4.1.5	ko:K00941,ko:K01724,ko:K01759,ko:K07032,ko:K08234	ko00620,ko00730,ko00790,ko01100,map00620,map00730,map00790,map01100	M00127	R02530,R03471,R04509,R04734	RC00002,RC00004,RC00017,RC00740,RC01208	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Glyoxalase
SHD2_k127_6400575_82	1110502.TMO_1980	2.055e-29	119.0	COG0776@1|root,COG0776@2|Bacteria,1MZ5B@1224|Proteobacteria,2UC5G@28211|Alphaproteobacteria,2JTCN@204441|Rhodospirillales	204441|Rhodospirillales	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions	-	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
SHD2_k127_6400575_1	1121861.KB899918_gene3345	0.0	1188.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,2TR4E@28211|Alphaproteobacteria,2JQC9@204441|Rhodospirillales	204441|Rhodospirillales	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
SHD2_k127_6400575_9	631454.N177_1981	4.984e-227	708.0	COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria,2TS3R@28211|Alphaproteobacteria,1JNA9@119043|Rhodobiaceae	28211|Alphaproteobacteria	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044238,GO:0051301,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
SHD2_k127_6400575_48	1096546.WYO_4812	4.758e-92	306.0	COG0740@1|root,COG0740@2|Bacteria,1MV46@1224|Proteobacteria,2TR5M@28211|Alphaproteobacteria,1JQVS@119045|Methylobacteriaceae	28211|Alphaproteobacteria	OU	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
SHD2_k127_6400575_24	402881.Plav_3235	1.333e-153	497.0	COG0544@1|root,COG0544@2|Bacteria,1MUJP@1224|Proteobacteria,2TS8W@28211|Alphaproteobacteria,1JN59@119043|Rhodobiaceae	28211|Alphaproteobacteria	O	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
SHD2_k127_6400575_86	1120963.KB894491_gene1107	4.006e-10	61.0	2DE24@1|root,2ZK69@2|Bacteria,1P9N5@1224|Proteobacteria,1SU0Y@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_6400575_73	1333998.M2A_1082	1.19e-53	193.0	COG1247@1|root,COG1247@2|Bacteria,1RDNE@1224|Proteobacteria,2U9BP@28211|Alphaproteobacteria,4BTC8@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	M	Acetyltransferase (GNAT) domain	pat	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006473,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564	2.3.1.183	ko:K03823	ko00440,ko01130,map00440,map01130	-	R08871,R08938	RC00004,RC00064	ko00000,ko00001,ko01000	-	-	-	Acetyltransf_4
SHD2_k127_6400575_25	1282876.BAOK01000001_gene2264	2.277e-150	492.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1MU1Q@1224|Proteobacteria,2TT58@28211|Alphaproteobacteria,4BPFT@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	G	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	-	-	-	-	-	-	-	-	-	-	Carb_kinase,YjeF_N
SHD2_k127_6400575_70	670292.JH26_06925	2.696e-59	215.0	COG0454@1|root,COG0456@2|Bacteria,1RGJ0@1224|Proteobacteria,2VERV@28211|Alphaproteobacteria,1JZC8@119045|Methylobacteriaceae	28211|Alphaproteobacteria	K	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
SHD2_k127_6400575_79	1380394.JADL01000001_gene2170	6.303e-42	158.0	COG0346@1|root,COG0346@2|Bacteria,1NFR3@1224|Proteobacteria,2UMIM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
SHD2_k127_6400575_21	1207063.P24_00635	2.109e-156	506.0	COG0154@1|root,COG0154@2|Bacteria,1MW3Z@1224|Proteobacteria,2TS56@28211|Alphaproteobacteria,2JP87@204441|Rhodospirillales	204441|Rhodospirillales	J	Amidase	-	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
SHD2_k127_6400575_74	1333998.M2A_1085	2.068e-51	188.0	COG0406@1|root,COG0406@2|Bacteria,1MYD7@1224|Proteobacteria,2TVST@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Phosphoglycerate mutase family	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
SHD2_k127_6400575_17	402881.Plav_3240	1.736e-179	579.0	COG0183@1|root,COG0183@2|Bacteria,1MVPC@1224|Proteobacteria,2VEVD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	acetyl-coa acetyltransferase	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	-
SHD2_k127_6400575_31	1110502.TMO_1991	3.25e-132	432.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,2TTGJ@28211|Alphaproteobacteria,2JQ2F@204441|Rhodospirillales	204441|Rhodospirillales	E	Aspartate tyrosine aromatic aminotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
SHD2_k127_6400575_35	222534.KB893722_gene513	1.545e-126	429.0	COG3653@1|root,COG3653@2|Bacteria,2IE6H@201174|Actinobacteria	201174|Actinobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
SHD2_k127_6400575_71	1333998.M2A_1091	1.499e-57	201.0	COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,2U73Z@28211|Alphaproteobacteria,4BQ9M@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	K	Belongs to the P(II) protein family	glnB	GO:0003674,GO:0006808,GO:0008150,GO:0030234,GO:0050789,GO:0050790,GO:0065007,GO:0065009,GO:0098772	-	ko:K04751	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
SHD2_k127_6400575_6	1150469.RSPPHO_03033	9.584e-239	744.0	COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,2TSCR@28211|Alphaproteobacteria,2JPN8@204441|Rhodospirillales	204441|Rhodospirillales	E	glutamine synthetase	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
SHD2_k127_6400575_63	1101191.KI912577_gene4339	2.722e-71	259.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2TUYS@28211|Alphaproteobacteria,1JRR2@119045|Methylobacteriaceae	28211|Alphaproteobacteria	T	PFAM ATP-binding region ATPase domain protein	MA20_25925	-	2.7.13.3	ko:K07716	ko02020,ko04112,map02020,map04112	M00511	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA
SHD2_k127_6400575_2	1411123.JQNH01000001_gene2009	1.029e-290	908.0	COG0187@1|root,COG0187@2|Bacteria,1MVH1@1224|Proteobacteria,2TQZV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule	parE	-	-	ko:K02622	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
SHD2_k127_6400575_56	1122603.ATVI01000007_gene1457	7.709e-82	300.0	COG2234@1|root,COG2234@2|Bacteria,1R56X@1224|Proteobacteria,1SZ1B@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
SHD2_k127_6400575_59	1173027.Mic7113_2954	1.84e-76	267.0	COG3000@1|root,COG3000@2|Bacteria,1G6AD@1117|Cyanobacteria	1117|Cyanobacteria	I	PFAM Fatty acid hydroxylase	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
SHD2_k127_6400575_76	204669.Acid345_3584	4.791e-50	181.0	COG0346@1|root,COG0346@2|Bacteria,3Y5YF@57723|Acidobacteria,2JNP7@204432|Acidobacteriia	204432|Acidobacteriia	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
SHD2_k127_6400575_20	1502851.FG93_03534	5.803e-169	546.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2TR6Q@28211|Alphaproteobacteria,3JS2G@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Belongs to the DEAD box helicase family	rhlE	-	3.6.4.13	ko:K03732,ko:K11927	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03019	-	-	-	DEAD,Helicase_C
SHD2_k127_6400575_18	1280947.HY30_12430	2.77e-174	554.0	COG1680@1|root,COG1680@2|Bacteria,1QD0J@1224|Proteobacteria,2U189@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	COG1680 Beta-lactamase class C and other penicillin binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
SHD2_k127_6400575_80	84531.JMTZ01000042_gene1155	2.304e-36	151.0	COG3570@1|root,COG3570@2|Bacteria,1MW4R@1224|Proteobacteria,1S2D2@1236|Gammaproteobacteria,1XC0Y@135614|Xanthomonadales	135614|Xanthomonadales	V	Aminoglycoside/hydroxyurea antibiotic resistance kinase	-	-	2.7.1.72	ko:K04343	-	M00766	R02225	RC00002,RC00078	br01600,ko00000,ko00002,ko01000,ko01504	-	-	-	APH_6_hur
SHD2_k127_6400575_33	288000.BBta_6971	3.97e-130	419.0	COG1028@1|root,COG1028@2|Bacteria,1MU5Y@1224|Proteobacteria,2TRNQ@28211|Alphaproteobacteria,3JRK8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IQ	KR domain	MA20_18175	-	1.1.1.30	ko:K00019	ko00072,ko00650,ko01100,map00072,map00650,map01100	M00088	R01361	RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	adh_short_C2
SHD2_k127_6400575_12	1121949.AQXT01000002_gene564	2.506e-219	689.0	COG1012@1|root,COG1012@2|Bacteria,1MVGW@1224|Proteobacteria,2TR9T@28211|Alphaproteobacteria,43X0K@69657|Hyphomonadaceae	28211|Alphaproteobacteria	C	belongs to the aldehyde dehydrogenase family	calB	-	1.2.1.68,1.2.99.10	ko:K00154,ko:K22445	-	-	-	-	ko00000,ko01000	-	-	-	Aldedh
SHD2_k127_6400575_57	1479238.JQMZ01000001_gene1664	2.159e-80	284.0	COG2199@1|root,COG3706@2|Bacteria,1NC00@1224|Proteobacteria,2TU9T@28211|Alphaproteobacteria,43XHZ@69657|Hyphomonadaceae	28211|Alphaproteobacteria	T	COG2199 FOG GGDEF domain	MA20_30680	-	2.7.7.65	ko:K07216,ko:K13590	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000	-	-	-	GGDEF
SHD2_k127_647371_1	1038866.KB902775_gene5358	3.243e-91	300.0	COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,2TR9U@28211|Alphaproteobacteria,3JTEV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
SHD2_k127_647371_2	1380355.JNIJ01000004_gene3006	1.342e-29	123.0	2A26K@1|root,30QH7@2|Bacteria,1RJDH@1224|Proteobacteria,2UB2U@28211|Alphaproteobacteria,3JZP0@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_647371_0	1245469.S58_14830	6.424e-235	732.0	COG2124@1|root,COG2124@2|Bacteria,1N0ID@1224|Proteobacteria,2TT7V@28211|Alphaproteobacteria,3JX3I@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	cytochrome P450	-	-	-	ko:K21034	-	-	-	-	ko00000,ko00199	-	-	-	p450
SHD2_k127_647371_3	1192124.LIG30_4562	1.602e-24	108.0	COG1592@1|root,COG1592@2|Bacteria,1RC1F@1224|Proteobacteria,2W71P@28216|Betaproteobacteria,1KDJC@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
SHD2_k127_647371_4	395964.KE386496_gene1239	1.265e-11	64.0	COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,2TRTJ@28211|Alphaproteobacteria,3NBD5@45404|Beijerinckiaceae	28211|Alphaproteobacteria	P	PFAM Di-haem cytochrome c peroxidase	ccpA	-	1.11.1.5	ko:K00428	-	-	-	-	ko00000,ko01000	-	-	-	CCP_MauG,Cytochrom_C
SHD2_k127_6517658_2	1120934.KB894419_gene2119	2.829e-45	171.0	COG2936@1|root,COG2936@2|Bacteria,2GKZH@201174|Actinobacteria,4E0CY@85010|Pseudonocardiales	201174|Actinobacteria	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
SHD2_k127_6517658_3	1120934.KB894419_gene2119	4.337e-42	161.0	COG2936@1|root,COG2936@2|Bacteria,2GKZH@201174|Actinobacteria,4E0CY@85010|Pseudonocardiales	201174|Actinobacteria	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
SHD2_k127_6517658_1	452662.SJA_C1-02370	1.143e-106	353.0	COG1024@1|root,COG1024@2|Bacteria,1MVB1@1224|Proteobacteria,2TVK3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Catalyzes the conversion of feruloyl-CoA to vanillin and acetyl-CoA	ech	-	4.1.2.41,4.2.1.101	ko:K18383	ko00360,ko01100,ko01110,map00360,map01100,map01110	-	R05772,R05773	RC00307,RC01468,RC01828	ko00000,ko00001,ko01000	-	-	-	ECH_1
SHD2_k127_6517658_4	1144275.COCOR_03608	5.587e-20	98.0	COG1309@1|root,COG1309@2|Bacteria,1N9ZB@1224|Proteobacteria,42VC2@68525|delta/epsilon subdivisions,2WRA9@28221|Deltaproteobacteria,2Z2TF@29|Myxococcales	28221|Deltaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
SHD2_k127_6517658_0	1231391.AMZF01000022_gene1261	1.318e-149	479.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2VHT0@28216|Betaproteobacteria,3T2I2@506|Alcaligenaceae	28216|Betaproteobacteria	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
SHD2_k127_6520840_23	365046.Rta_17370	4.636e-47	170.0	COG0621@1|root,COG0621@2|Bacteria,1MU7N@1224|Proteobacteria,2VI16@28216|Betaproteobacteria,4ABTY@80864|Comamonadaceae	28216|Betaproteobacteria	J	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12	rimO	-	2.8.4.4	ko:K14441	-	-	R10652	RC00003,RC03217	ko00000,ko01000,ko03009	-	-	-	Radical_SAM,TRAM,UPF0004
SHD2_k127_6520840_24	114615.BRADO6695	9.531e-46	167.0	COG0393@1|root,COG0393@2|Bacteria,1N2F5@1224|Proteobacteria,2UDZU@28211|Alphaproteobacteria,3JZS1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Putative heavy-metal-binding	-	-	-	-	-	-	-	-	-	-	-	-	YbjQ_1
SHD2_k127_6520840_31	1382303.JPOM01000001_gene850	1.688e-11	68.0	2EGVF@1|root,31AZP@2|Bacteria,1Q6M4@1224|Proteobacteria,2UN34@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_6520840_11	1207063.P24_06746	1.879e-101	339.0	COG0702@1|root,COG0702@2|Bacteria,1MW54@1224|Proteobacteria,2TQMD@28211|Alphaproteobacteria,2JPKA@204441|Rhodospirillales	204441|Rhodospirillales	GM	NmrA-like family	-	-	1.6.5.3,1.6.99.3	ko:K00329,ko:K00356	ko00190,map00190	-	R11945	RC00061	ko00000,ko00001,ko01000	-	-	-	3Beta_HSD,Epimerase,NAD_binding_10,RmlD_sub_bind
SHD2_k127_6520840_18	1380391.JIAS01000018_gene807	3.065e-75	262.0	COG1968@1|root,COG1968@2|Bacteria,1MX02@1224|Proteobacteria,2TSUR@28211|Alphaproteobacteria,2JPZY@204441|Rhodospirillales	204441|Rhodospirillales	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
SHD2_k127_6520840_32	935557.ATYB01000009_gene887	9.285e-11	64.0	COG3847@1|root,COG3847@2|Bacteria,1NGVU@1224|Proteobacteria,2UJE8@28211|Alphaproteobacteria,4BGUV@82115|Rhizobiaceae	28211|Alphaproteobacteria	U	Flp pilus assembly protein, pilin Flp	MA20_03885	-	-	ko:K02651	ko04112,map04112	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	Flp_Fap
SHD2_k127_6520840_22	269796.Rru_A0027	4.881e-56	204.0	COG0744@1|root,COG0744@2|Bacteria,1RDAQ@1224|Proteobacteria,2U0NP@28211|Alphaproteobacteria,2JS5A@204441|Rhodospirillales	204441|Rhodospirillales	M	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors	mtgA	-	2.4.1.129	ko:K03814	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly
SHD2_k127_6520840_25	402881.Plav_0199	2.011e-44	169.0	COG0625@1|root,COG0625@2|Bacteria,1MXM4@1224|Proteobacteria,2TTXD@28211|Alphaproteobacteria,1JNZD@119043|Rhodobiaceae	28211|Alphaproteobacteria	O	Glutathione S-transferase, C-terminal domain	gst	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_2,GST_C_3,GST_N_3
SHD2_k127_6520840_2	670292.JH26_22270	5.457e-150	482.0	COG1600@1|root,COG1600@2|Bacteria,1MV1H@1224|Proteobacteria,2TR5E@28211|Alphaproteobacteria,1JRBH@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	4Fe-4S double cluster binding domain	queG	GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0052693,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1730,Fer4_16,HEAT_2
SHD2_k127_6520840_29	1123060.JONP01000010_gene2216	1.21e-35	146.0	COG0457@1|root,COG0457@2|Bacteria,1RK4Q@1224|Proteobacteria,2UBBB@28211|Alphaproteobacteria,2JSKY@204441|Rhodospirillales	204441|Rhodospirillales	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_9
SHD2_k127_6520840_16	1123072.AUDH01000009_gene472	3.658e-81	277.0	COG1073@1|root,COG1073@2|Bacteria,1MX88@1224|Proteobacteria,2TSRE@28211|Alphaproteobacteria,2JQD5@204441|Rhodospirillales	204441|Rhodospirillales	S	hydrolases or acyltransferases (alpha beta hydrolase superfamily)	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
SHD2_k127_6520840_7	1121957.ATVL01000010_gene392	1.493e-117	397.0	COG0501@1|root,COG0501@2|Bacteria,4NESF@976|Bacteroidetes,47KTS@768503|Cytophagia	976|Bacteroidetes	O	Zn-dependent protease with chaperone function	-	-	3.4.24.84	ko:K03799,ko:K06013	ko00900,ko01130,map00900,map01130	M00743	R09845	RC00141	ko00000,ko00001,ko00002,ko01000,ko01002,ko04147	-	-	-	Peptidase_M48,Peptidase_M48_N
SHD2_k127_6520840_13	196490.AUEZ01000017_gene3273	2.466e-92	317.0	COG0040@1|root,COG0040@2|Bacteria,1MUCY@1224|Proteobacteria,2TT0H@28211|Alphaproteobacteria,3JTWP@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	F	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity	hisG	GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG,HisG_C
SHD2_k127_6520840_14	402881.Plav_0599	9.273e-92	317.0	COG3705@1|root,COG3705@2|Bacteria,1MWIG@1224|Proteobacteria,2TTQ4@28211|Alphaproteobacteria,1JNST@119043|Rhodobiaceae	28211|Alphaproteobacteria	E	Histidyl-tRNA synthetase	hisZ	-	-	ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002	-	-	-	tRNA-synt_His
SHD2_k127_6520840_1	136993.KB900626_gene3610	1.326e-163	530.0	COG0124@1|root,COG1833@1|root,COG0124@2|Bacteria,COG1833@2|Bacteria,1MV2K@1224|Proteobacteria,2TSTH@28211|Alphaproteobacteria,36XQ6@31993|Methylocystaceae	28211|Alphaproteobacteria	J	Histidyl-tRNA synthetase	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
SHD2_k127_6520840_0	1333998.M2A_0166	1.947e-232	741.0	COG2010@1|root,COG4993@1|root,COG2010@2|Bacteria,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2TS2Q@28211|Alphaproteobacteria,4BTBE@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	CG	PQQ enzyme repeat	-	-	1.1.9.1	ko:K17760	-	-	-	-	ko00000,ko01000	-	-	-	Cytochrome_CBB3,PQQ,PQQ_2
SHD2_k127_6520840_27	172088.AUGA01000001_gene6629	1.204e-37	146.0	2CRBS@1|root,32SNS@2|Bacteria,1RAPW@1224|Proteobacteria,2U90B@28211|Alphaproteobacteria,3JY3I@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
SHD2_k127_6520840_9	756272.Plabr_0937	2.977e-115	385.0	COG2124@1|root,COG2124@2|Bacteria,2J1NM@203682|Planctomycetes	203682|Planctomycetes	C	cytochrome P450	-	-	-	ko:K15468	-	-	-	-	ko00000,ko01008	-	-	-	p450
SHD2_k127_6520840_20	246200.SPOA0272a	1.176e-64	226.0	2D579@1|root,32TID@2|Bacteria,1RH2N@1224|Proteobacteria,2U9TR@28211|Alphaproteobacteria,4NDCR@97050|Ruegeria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_6520840_21	1040987.AZUY01000023_gene1858	1.111e-61	224.0	COG1359@1|root,COG1359@2|Bacteria,1REMS@1224|Proteobacteria,2U8NY@28211|Alphaproteobacteria,43JWW@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	NIPSNAP	-	-	-	-	-	-	-	-	-	-	-	-	NIPSNAP
SHD2_k127_6520840_19	1122604.JONR01000059_gene1131	3.93e-71	243.0	COG0454@1|root,COG0454@2|Bacteria,1R2FR@1224|Proteobacteria,1T5QA@1236|Gammaproteobacteria,1X8Y0@135614|Xanthomonadales	135614|Xanthomonadales	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
SHD2_k127_6520840_12	1120705.FG95_00710	5.353e-100	335.0	COG0697@1|root,COG0697@2|Bacteria,1PHRI@1224|Proteobacteria,2TUAQ@28211|Alphaproteobacteria,2K69R@204457|Sphingomonadales	204457|Sphingomonadales	EG	of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
SHD2_k127_6520840_30	1131814.JAFO01000001_gene381	2.442e-27	119.0	COG5517@1|root,COG5517@2|Bacteria,1RCCB@1224|Proteobacteria,2VGYR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Ring hydroxylating beta subunit	-	-	1.14.12.1	ko:K16320	ko00627,ko01120,map00627,map01120	M00637	R00823,R00825	RC00192	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	Ring_hydroxyl_B
SHD2_k127_6520840_4	397945.Aave_0165	1e-139	455.0	COG4638@1|root,COG4638@2|Bacteria,1MWXW@1224|Proteobacteria,2VM92@28216|Betaproteobacteria,4ACS4@80864|Comamonadaceae	28216|Betaproteobacteria	P	Rieske 2Fe-2S domain protein	nagG	-	1.14.12.1,1.14.13.172	ko:K16319,ko:K18242	ko00626,ko00627,ko01120,map00626,map00627,map01120	M00637,M00638	R00823,R00825,R07709,R07710	RC00192,RC00490	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	Rieske,Ring_hydroxyl_A
SHD2_k127_6520840_8	3988.XP_002536891.1	2.739e-115	381.0	COG0329@1|root,2QQ8M@2759|Eukaryota	2759|Eukaryota	EM	4-hydroxy-tetrahydrodipicolinate synthase	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS,Saccharop_dh_N
SHD2_k127_6520840_6	1003200.AXXA_06233	2.401e-120	396.0	COG3435@1|root,COG3435@2|Bacteria,1R7Q6@1224|Proteobacteria	1224|Proteobacteria	Q	Gentisate 1,2-dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,Cupin_2
SHD2_k127_6520840_17	13689.BV96_04320	1.501e-77	270.0	COG2423@1|root,COG2423@2|Bacteria,1N3EI@1224|Proteobacteria,2UI65@28211|Alphaproteobacteria,2K3ZS@204457|Sphingomonadales	204457|Sphingomonadales	E	Ornithine cyclodeaminase/mu-crystallin family	-	-	4.3.1.12	ko:K01750	ko00330,ko01110,ko01130,ko01230,map00330,map01110,map01130,map01230	-	R00671	RC00354	ko00000,ko00001,ko01000	-	-	-	OCD_Mu_crystall
SHD2_k127_6520840_26	1003200.AXXA_06223	8.454e-38	153.0	COG2128@1|root,COG2128@2|Bacteria,1NVGV@1224|Proteobacteria	1224|Proteobacteria	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
SHD2_k127_6520840_5	196367.JNFG01000002_gene2265	2.591e-137	450.0	COG1960@1|root,COG1960@2|Bacteria,1P7WH@1224|Proteobacteria,2VMPJ@28216|Betaproteobacteria,1K4I6@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M
SHD2_k127_6520840_3	748247.AZKH_1901	5.11e-147	473.0	COG0702@1|root,COG0702@2|Bacteria	2|Bacteria	GM	epimerase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase,NAD_binding_10,NmrA
SHD2_k127_6520840_28	1282876.BAOK01000001_gene3171	1.82e-36	144.0	2DMP1@1|root,32SS8@2|Bacteria,1MZTD@1224|Proteobacteria,2U86W@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF3237)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3237
SHD2_k127_6520840_10	384765.SIAM614_30981	5.286e-107	354.0	COG1073@1|root,COG1073@2|Bacteria,1MUCD@1224|Proteobacteria,2U21F@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	X-Pro dipeptidyl-peptidase (S15 family)	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	AXE1,Peptidase_S15
SHD2_k127_6523798_1	670292.JH26_03925	8.755e-75	256.0	COG0686@1|root,COG0686@2|Bacteria,1QTX1@1224|Proteobacteria,2TYK7@28211|Alphaproteobacteria,1JZHM@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	Alanine dehydrogenase/PNT, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
SHD2_k127_6523798_0	580332.Slit_1196	2.371e-242	773.0	COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,2VJ54@28216|Betaproteobacteria	28216|Betaproteobacteria	O	Belongs to the peptidase S16 family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_32,Lon_C
SHD2_k127_6523798_2	69279.BG36_14060	2.712e-22	107.0	2EVJY@1|root,33P02@2|Bacteria,1NMNA@1224|Proteobacteria,2UMPN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_6551240_10	426716.JOAJ01000001_gene803	4.642e-148	484.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4FTYX@85025|Nocardiaceae	201174|Actinobacteria	IQ	Acyl-CoA synthetase	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
SHD2_k127_6551240_19	1423321.AS29_13880	1.903e-65	237.0	COG1735@1|root,COG1735@2|Bacteria,1TS8I@1239|Firmicutes,4HDZF@91061|Bacilli,1ZR3D@1386|Bacillus	91061|Bacilli	S	Phosphotriesterase family	-	-	-	ko:K07048	-	-	-	-	ko00000	-	-	-	PTE
SHD2_k127_6551240_23	1174684.EBMC1_05449	4.248e-50	187.0	29CWT@1|root,2ZZUX@2|Bacteria,1REF2@1224|Proteobacteria,2U7K7@28211|Alphaproteobacteria,2K4SS@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function (DUF2585)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2585
SHD2_k127_6551240_15	358220.C380_06070	2.453e-93	313.0	COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,2VGZV@28216|Betaproteobacteria,4AAJR@80864|Comamonadaceae	28216|Betaproteobacteria	S	Polyphosphate kinase 2 (PPK2)	-	-	2.7.4.1	ko:K22468	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PPK2
SHD2_k127_6551240_20	1123269.NX02_15130	7.885e-62	224.0	COG1120@1|root,COG1120@2|Bacteria,1QPWJ@1224|Proteobacteria,2U1TK@28211|Alphaproteobacteria,2K1EJ@204457|Sphingomonadales	204457|Sphingomonadales	HP	ABC transporter	-	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
SHD2_k127_6551240_16	1249627.D779_1849	4.152e-85	294.0	COG0609@1|root,COG0609@2|Bacteria,1MV9W@1224|Proteobacteria,1RMDF@1236|Gammaproteobacteria,1WXHV@135613|Chromatiales	135613|Chromatiales	U	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily	-	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
SHD2_k127_6551240_27	426355.Mrad2831_6078	1.809e-23	111.0	COG0614@1|root,COG0614@2|Bacteria,1RAUP@1224|Proteobacteria,2TUB0@28211|Alphaproteobacteria,1JS7D@119045|Methylobacteriaceae	28211|Alphaproteobacteria	P	PFAM periplasmic binding protein	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
SHD2_k127_6551240_13	1234364.AMSF01000061_gene2084	1.238e-100	351.0	COG0793@1|root,COG0793@2|Bacteria,1N4T9@1224|Proteobacteria,1SE36@1236|Gammaproteobacteria,1X70X@135614|Xanthomonadales	135614|Xanthomonadales	M	Aspartyl protease	-	-	-	-	-	-	-	-	-	-	-	-	Asp_protease_2,PDZ_2
SHD2_k127_6551240_3	1333998.M2A_1963	2.808e-250	785.0	COG1960@1|root,COG1960@2|Bacteria,1R5AN@1224|Proteobacteria,2UP4B@28211|Alphaproteobacteria,4BTAV@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	I	Acyl-CoA dehydrogenase N terminal	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N
SHD2_k127_6551240_14	509191.AEDB02000002_gene1153	1.407e-94	319.0	COG1816@1|root,COG1816@2|Bacteria,1UCEX@1239|Firmicutes,25CFQ@186801|Clostridia,3WJ70@541000|Ruminococcaceae	186801|Clostridia	F	Adenosine/AMP deaminase	-	-	3.5.4.4	ko:K01488	ko00230,ko01100,ko05340,map00230,map01100,map05340	-	R01560,R02556	RC00477	ko00000,ko00001,ko01000	-	-	-	A_deaminase
SHD2_k127_6551240_25	1336208.JADY01000009_gene2579	1.215e-34	138.0	2CC0C@1|root,32RUG@2|Bacteria,1MZVQ@1224|Proteobacteria,2UBWU@28211|Alphaproteobacteria,2JXTJ@204441|Rhodospirillales	204441|Rhodospirillales	S	Protein of unknown function (DUF3297)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3297
SHD2_k127_6551240_0	402881.Plav_3081	0.0	1404.0	COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,2TR2H@28211|Alphaproteobacteria,1JN56@119043|Rhodobiaceae	28211|Alphaproteobacteria	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
SHD2_k127_6551240_28	314260.PB2503_10794	1.096e-18	92.0	COG2938@1|root,COG2938@2|Bacteria,1N6SJ@1224|Proteobacteria,2UFF5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Flavinator of succinate dehydrogenase	-	-	-	ko:K09159	-	-	-	-	ko00000,ko02048	-	-	-	Sdh5
SHD2_k127_6551240_2	1333998.M2A_0447	1.842e-285	892.0	COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,2TR86@28211|Alphaproteobacteria,4BPUE@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
SHD2_k127_6551240_12	402881.Plav_3076	9.754e-107	358.0	COG3173@1|root,COG3173@2|Bacteria,1MY0Y@1224|Proteobacteria,2TRMW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Aminoglycoside phosphotransferase	MA20_16375	-	-	-	-	-	-	-	-	-	-	-	APH
SHD2_k127_6551240_26	402881.Plav_3075	4.326e-33	137.0	2DRHM@1|root,32UR4@2|Bacteria,1RCYI@1224|Proteobacteria,2UAAG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_6551240_22	1304885.AUEY01000011_gene1770	2.201e-51	201.0	2AEFS@1|root,314AU@2|Bacteria,1RKTV@1224|Proteobacteria,42YDD@68525|delta/epsilon subdivisions,2WUI4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_6551240_17	443143.GM18_1316	3.128e-76	270.0	COG1131@1|root,COG1131@2|Bacteria,1MY19@1224|Proteobacteria,42YBW@68525|delta/epsilon subdivisions,2WUJC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SHD2_k127_6551240_18	1121123.AUAO01000001_gene830	1.675e-68	243.0	COG0667@1|root,COG0667@2|Bacteria,1RC4U@1224|Proteobacteria,2U6NK@28211|Alphaproteobacteria,2KGCP@204458|Caulobacterales	204458|Caulobacterales	C	aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
SHD2_k127_6551240_11	592015.HMPREF1705_01245	7.918e-142	462.0	COG0399@1|root,COG0399@2|Bacteria,3T9SV@508458|Synergistetes	508458|Synergistetes	E	Belongs to the DegT DnrJ EryC1 family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
SHD2_k127_6551240_9	1161401.ASJA01000004_gene2183	3.388e-151	485.0	COG1086@1|root,COG1086@2|Bacteria,1MWKY@1224|Proteobacteria,2TT4K@28211|Alphaproteobacteria,43W91@69657|Hyphomonadaceae	28211|Alphaproteobacteria	M	NAD(P)H-binding	-	-	4.2.1.115	ko:K15894	ko00520,map00520	-	R09697	RC02609	ko00000,ko00001,ko01000	-	-	-	Polysacc_synt_2
SHD2_k127_6551240_5	1035191.HMPREF0185_00556	1.972e-196	620.0	COG1004@1|root,COG1004@2|Bacteria,1MW5U@1224|Proteobacteria,2TREV@28211|Alphaproteobacteria,2KG3N@204458|Caulobacterales	204458|Caulobacterales	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	-	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
SHD2_k127_6551240_1	1380391.JIAS01000012_gene4223	0.0	1004.0	COG0529@1|root,COG2895@1|root,COG0529@2|Bacteria,COG2895@2|Bacteria,1MUD9@1224|Proteobacteria,2TQNJ@28211|Alphaproteobacteria,2JPGB@204441|Rhodospirillales	204441|Rhodospirillales	P	Catalyzes the synthesis of activated sulfate	cysC	-	2.7.1.25,2.7.7.4	ko:K00955	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176	R00509,R00529,R04928,R04929	RC00002,RC00078,RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase,GTP_EFTU,GTP_EFTU_D2
SHD2_k127_6551240_8	1380391.JIAS01000012_gene4224	5.144e-176	556.0	COG0175@1|root,COG0175@2|Bacteria,1MUCZ@1224|Proteobacteria,2TT2D@28211|Alphaproteobacteria,2JQKR@204441|Rhodospirillales	204441|Rhodospirillales	EH	COG0175 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase) FAD synthetase and related enzymes	cysD	-	2.7.7.4	ko:K00957	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	PAPS_reduct
SHD2_k127_6551240_21	518766.Rmar_0714	5.423e-53	201.0	28IX1@1|root,2Z8V3@2|Bacteria,4NHFP@976|Bacteroidetes,1FJ3K@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	Protein of unknown function (DUF2914)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2914
SHD2_k127_6551240_6	292415.Tbd_1239	9.294e-181	578.0	COG0662@1|root,COG0836@1|root,COG0662@2|Bacteria,COG0836@2|Bacteria,1MV39@1224|Proteobacteria,2VI4S@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Belongs to the mannose-6-phosphate isomerase type 2 family	xanB	-	2.7.7.13,5.3.1.8	ko:K16011	ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025	M00114,M00362	R00885,R01819	RC00002,RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
SHD2_k127_6551240_4	402881.Plav_3070	2.767e-217	679.0	COG0183@1|root,COG0183@2|Bacteria,1MU8C@1224|Proteobacteria,2TS6P@28211|Alphaproteobacteria,1JP48@119043|Rhodobiaceae	28211|Alphaproteobacteria	I	Thiolase, N-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
SHD2_k127_6551240_7	228405.HNE_0057	3.297e-178	565.0	COG2159@1|root,COG2159@2|Bacteria,1P6G6@1224|Proteobacteria,2TU10@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	metal-dependent hydrolase of the TIM-barrel fold	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
SHD2_k127_6551240_24	402881.Plav_3069	2.479e-36	139.0	COG1545@1|root,COG3425@1|root,COG1545@2|Bacteria,COG3425@2|Bacteria,1QV6D@1224|Proteobacteria,2TTB1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	3-Oxoacyl- acyl-carrier-protein (ACP) synthase III	-	-	-	-	-	-	-	-	-	-	-	-	ACP_syn_III_C,OB_aCoA_assoc
SHD2_k127_6639183_0	1038859.AXAU01000030_gene6762	5.666e-238	745.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,2TRXG@28211|Alphaproteobacteria,3JVHX@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Transposase	-	-	-	ko:K07487	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
SHD2_k127_6639183_1	1411123.JQNH01000001_gene3185	8.016e-87	293.0	COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,2TRCK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	COG0339 Zn-dependent oligopeptidases	dcp	GO:0003674,GO:0003824,GO:0004180,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0016787,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.15.5	ko:K01284	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3
SHD2_k127_6656823_14	243159.AFE_2463	1.112e-88	307.0	2BZPA@1|root,2ZA2G@2|Bacteria,1NUVQ@1224|Proteobacteria,1SK2E@1236|Gammaproteobacteria,2NDQ1@225057|Acidithiobacillales	225057|Acidithiobacillales	S	Putative beta-barrel porin-2, OmpL-like. bbp2	-	-	-	-	-	-	-	-	-	-	-	-	BBP2
SHD2_k127_6656823_16	1333998.M2A_2577	2.657e-85	290.0	COG1028@1|root,COG1028@2|Bacteria,1PEWK@1224|Proteobacteria,2TV4E@28211|Alphaproteobacteria,4BQHP@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	IQ	KR domain	MA20_40070	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
SHD2_k127_6656823_22	1382303.JPOM01000001_gene669	4.409e-29	130.0	COG0406@1|root,COG0406@2|Bacteria,1N0M0@1224|Proteobacteria,2U8UN@28211|Alphaproteobacteria,2KGHA@204458|Caulobacterales	204458|Caulobacterales	G	phosphoglycerate mutase	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
SHD2_k127_6656823_19	1267535.KB906767_gene650	1.618e-66	235.0	COG0412@1|root,COG0412@2|Bacteria	2|Bacteria	Q	carboxymethylenebutenolidase activity	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
SHD2_k127_6656823_4	744980.TRICHSKD4_2077	4.674e-171	541.0	COG1052@1|root,COG1052@2|Bacteria,1MU2D@1224|Proteobacteria,2TSM8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	CH	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	gyaR	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	1.1.1.26	ko:K00015	ko00630,ko01100,ko01110,ko01120,map00630,map01100,map01110,map01120	-	R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
SHD2_k127_6656823_7	1429916.X566_12875	1.364e-144	475.0	COG1680@1|root,COG1680@2|Bacteria,1MVPR@1224|Proteobacteria,2TRWZ@28211|Alphaproteobacteria,3JQWG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	V	Beta-lactamase	MA20_17095	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
SHD2_k127_6656823_2	450851.PHZ_c3299	2.744e-207	652.0	COG1960@1|root,COG1960@2|Bacteria,1MU2V@1224|Proteobacteria,2TTUF@28211|Alphaproteobacteria,2KFDE@204458|Caulobacterales	204458|Caulobacterales	C	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
SHD2_k127_6656823_0	59538.XP_005973478.1	6.033e-284	885.0	COG0318@1|root,KOG1176@2759|Eukaryota,3AIZB@33154|Opisthokonta,3BXNQ@33208|Metazoa,3DFMP@33213|Bilateria,48SPA@7711|Chordata,49P71@7742|Vertebrata,3JP3T@40674|Mammalia,4J1NF@91561|Cetartiodactyla	33208|Metazoa	I	4-coumarate--CoA	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
SHD2_k127_6656823_17	1038860.AXAP01000102_gene4498	2.749e-84	283.0	COG3837@1|root,COG3837@2|Bacteria,1R9WZ@1224|Proteobacteria,2U6K6@28211|Alphaproteobacteria,3JXTD@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF861)	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
SHD2_k127_6656823_5	402881.Plav_1384	5.625e-168	545.0	COG1680@1|root,COG1680@2|Bacteria,1QD0J@1224|Proteobacteria,2U189@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	COG1680 Beta-lactamase class C and other penicillin binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
SHD2_k127_6656823_21	426117.M446_4258	1.312e-39	151.0	COG1186@1|root,COG1186@2|Bacteria,1RH75@1224|Proteobacteria,2U9M7@28211|Alphaproteobacteria,1JUJ6@119045|Methylobacteriaceae	28211|Alphaproteobacteria	J	Class I peptide chain release factor	MA20_05665	GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0003824,GO:0004045,GO:0005488,GO:0006412,GO:0006414,GO:0006415,GO:0006417,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016043,GO:0016150,GO:0016787,GO:0016788,GO:0019222,GO:0019538,GO:0022411,GO:0031323,GO:0031326,GO:0032268,GO:0032984,GO:0034248,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044877,GO:0050789,GO:0050794,GO:0051171,GO:0051246,GO:0052689,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0072344,GO:0080090,GO:0097159,GO:0140098,GO:0140101,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2000112	-	ko:K15034	-	-	-	-	ko00000,ko03012	-	-	-	RF-1
SHD2_k127_6656823_1	1333998.M2A_2493	4.638e-229	714.0	COG2141@1|root,COG2141@2|Bacteria,1MX64@1224|Proteobacteria,2TV8M@28211|Alphaproteobacteria,4BTBG@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
SHD2_k127_6656823_12	366602.Caul_4827	1.06e-100	336.0	COG1028@1|root,COG1028@2|Bacteria,1R4GD@1224|Proteobacteria,2TVNF@28211|Alphaproteobacteria,2KFS3@204458|Caulobacterales	204458|Caulobacterales	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
SHD2_k127_6656823_6	450851.PHZ_c3208	5.77e-147	476.0	COG1309@1|root,COG1309@2|Bacteria,1R7F8@1224|Proteobacteria,2U0DG@28211|Alphaproteobacteria,2KI2V@204458|Caulobacterales	204458|Caulobacterales	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
SHD2_k127_6656823_8	1382303.JPOM01000001_gene1408	2.872e-124	414.0	COG2211@1|root,COG2211@2|Bacteria,1MVUM@1224|Proteobacteria,2TVI8@28211|Alphaproteobacteria,2KJSU@204458|Caulobacterales	204458|Caulobacterales	G	MFS/sugar transport protein	-	-	-	-	-	-	-	-	-	-	-	-	MFS_2
SHD2_k127_6656823_9	1382303.JPOM01000001_gene1408	2.159e-116	393.0	COG2211@1|root,COG2211@2|Bacteria,1MVUM@1224|Proteobacteria,2TVI8@28211|Alphaproteobacteria,2KJSU@204458|Caulobacterales	204458|Caulobacterales	G	MFS/sugar transport protein	-	-	-	-	-	-	-	-	-	-	-	-	MFS_2
SHD2_k127_6656823_10	1382303.JPOM01000001_gene1408	2.892e-105	361.0	COG2211@1|root,COG2211@2|Bacteria,1MVUM@1224|Proteobacteria,2TVI8@28211|Alphaproteobacteria,2KJSU@204458|Caulobacterales	204458|Caulobacterales	G	MFS/sugar transport protein	-	-	-	-	-	-	-	-	-	-	-	-	MFS_2
SHD2_k127_6656823_3	234267.Acid_4001	3.115e-192	615.0	COG0122@1|root,COG2169@1|root,COG0122@2|Bacteria,COG2169@2|Bacteria,3Y578@57723|Acidobacteria	57723|Acidobacteria	K	AlkA N-terminal domain	-	-	3.2.2.21	ko:K13529	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03000,ko03400	-	-	-	Ada_Zn_binding,AlkA_N,HTH_18,HhH-GPD
SHD2_k127_6656823_20	588932.JHOF01000027_gene1753	5.881e-46	176.0	COG0350@1|root,COG0350@2|Bacteria,1N2YQ@1224|Proteobacteria,2TRRN@28211|Alphaproteobacteria,2KGW8@204458|Caulobacterales	204458|Caulobacterales	L	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated	-	-	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1,Methyltransf_1N
SHD2_k127_6656823_18	1144275.COCOR_03478	2.27e-79	273.0	COG2513@1|root,COG2513@2|Bacteria,1N4VT@1224|Proteobacteria,42NZ1@68525|delta/epsilon subdivisions	1224|Proteobacteria	G	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate	prpB	-	4.1.3.30	ko:K03417	ko00640,map00640	-	R00409	RC00286,RC00287	ko00000,ko00001,ko01000	-	-	-	PEP_mutase
SHD2_k127_6656823_11	1333998.M2A_2035	2.25e-103	350.0	COG5002@1|root,COG5002@2|Bacteria,1MWF3@1224|Proteobacteria,2TR46@28211|Alphaproteobacteria,4BQ1W@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	phoR	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS_4,PAS_8
SHD2_k127_6656823_15	1333998.M2A_2040	3.396e-86	291.0	COG0704@1|root,COG0704@2|Bacteria,1MUMI@1224|Proteobacteria,2TQMN@28211|Alphaproteobacteria,4BQFJ@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	P	Plays a role in the regulation of phosphate uptake	phoU	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
SHD2_k127_6656823_13	402881.Plav_0399	2.863e-92	306.0	COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,2TRFZ@28211|Alphaproteobacteria,1JNDD@119043|Rhodobiaceae	28211|Alphaproteobacteria	T	Transcriptional regulatory protein, C terminal	phoB	-	-	ko:K07657	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
SHD2_k127_6674884_98	1121123.AUAO01000001_gene887	1.006e-22	99.0	COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,2UF6W@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Cold shock	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
SHD2_k127_6674884_107	1131814.JAFO01000001_gene462	1.615e-13	77.0	2DXAI@1|root,3444M@2|Bacteria,1P0TN@1224|Proteobacteria,2UVMP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_3
SHD2_k127_6674884_95	1121123.AUAO01000001_gene887	4.81e-24	102.0	COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,2UF6W@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Cold shock	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
SHD2_k127_6674884_24	1348635.BBJY01000001_gene2415	3.621e-135	449.0	COG0534@1|root,COG0534@2|Bacteria,1MVRV@1224|Proteobacteria,1RRDQ@1236|Gammaproteobacteria,1XYN5@135623|Vibrionales	135623|Vibrionales	V	MatE	-	-	-	-	-	-	-	-	-	-	-	-	MatE
SHD2_k127_6674884_74	1230476.C207_06137	8.13e-47	172.0	COG0748@1|root,COG0748@2|Bacteria,1RBVH@1224|Proteobacteria,2U6I3@28211|Alphaproteobacteria,3JY7V@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Pyridoxamine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
SHD2_k127_6674884_108	1380391.JIAS01000015_gene356	4.499e-12	72.0	2A359@1|root,30RKG@2|Bacteria,1Q85W@1224|Proteobacteria,2UVE2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_6674884_106	596154.Alide2_1460	2.505e-14	78.0	COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria,2VIEU@28216|Betaproteobacteria,4A9Q7@80864|Comamonadaceae	28216|Betaproteobacteria	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	-	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
SHD2_k127_6674884_81	1168059.KB899087_gene2247	1.486e-37	148.0	COG2032@1|root,COG2032@2|Bacteria,1RKYS@1224|Proteobacteria,2VGDV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	sodC	GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003824,GO:0004784,GO:0005488,GO:0005507,GO:0005575,GO:0005576,GO:0005615,GO:0006801,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008270,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016721,GO:0019430,GO:0033554,GO:0034599,GO:0034614,GO:0042221,GO:0043167,GO:0043169,GO:0044237,GO:0044421,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071450,GO:0071451,GO:0072593,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1901701,GO:1990748	1.15.1.1	ko:K04565	ko04146,ko04213,ko05014,ko05016,ko05020,map04146,map04213,map05014,map05016,map05020	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Cu
SHD2_k127_6674884_56	935567.JAES01000003_gene231	1.338e-70	244.0	COG0625@1|root,COG0625@2|Bacteria,1REDI@1224|Proteobacteria,1S13N@1236|Gammaproteobacteria,1X4XE@135614|Xanthomonadales	135614|Xanthomonadales	O	Belongs to the GST superfamily	gst5	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_N,GST_N_3
SHD2_k127_6674884_93	1479238.JQMZ01000001_gene619	8.736e-25	104.0	COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,2UF6W@28211|Alphaproteobacteria,4408X@69657|Hyphomonadaceae	28211|Alphaproteobacteria	K	Cold shock protein domain	MA20_05565	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
SHD2_k127_6674884_40	944547.ABLL_2027	5.006e-97	323.0	COG0580@1|root,COG0580@2|Bacteria,1MXTJ@1224|Proteobacteria,42MR4@68525|delta/epsilon subdivisions,2YMFI@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	G	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity	aqpZ	-	-	ko:K06188	-	-	-	-	ko00000,ko02000	1.A.8	-	-	MIP
SHD2_k127_6674884_0	402881.Plav_3602	4.67e-321	1014.0	COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,2TSV0@28211|Alphaproteobacteria,1JNF6@119043|Rhodobiaceae	28211|Alphaproteobacteria	O	Metal dependent phosphohydrolases with conserved 'HD' motif.	glnD	GO:0006355,GO:0006464,GO:0006807,GO:0006808,GO:0007154,GO:0007584,GO:0008150,GO:0008152,GO:0009605,GO:0009719,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0009991,GO:0010033,GO:0010243,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0018175,GO:0018177,GO:0019219,GO:0019222,GO:0019538,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0031670,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0070887,GO:0071310,GO:0071417,GO:0071495,GO:0071496,GO:0071704,GO:0080090,GO:0090293,GO:1901564,GO:1901698,GO:1901699,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	ACT,GlnD_UR_UTase,GlnE,HD,NTP_transf_2
SHD2_k127_6674884_20	582899.Hden_3477	9.428e-139	448.0	COG0180@1|root,COG0180@2|Bacteria,1MV4T@1224|Proteobacteria,2TQZX@28211|Alphaproteobacteria,3N6IB@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	Tryptophanyl-tRNA synthetase	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
SHD2_k127_6674884_59	349163.Acry_1649	8.983e-65	234.0	COG1028@1|root,COG1028@2|Bacteria,1MUUV@1224|Proteobacteria,2TR0A@28211|Alphaproteobacteria,2JWK9@204441|Rhodospirillales	204441|Rhodospirillales	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
SHD2_k127_6674884_88	1122604.JONR01000010_gene4007	2.53e-32	134.0	COG1539@1|root,COG1539@2|Bacteria,1NFE2@1224|Proteobacteria	1224|Proteobacteria	H	Dihydroneopterin aldolase	-	-	-	-	-	-	-	-	-	-	-	-	FolB
SHD2_k127_6674884_86	402881.Plav_2277	8.802e-33	133.0	COG1539@1|root,COG1539@2|Bacteria,1PSIH@1224|Proteobacteria,2V9CM@28211|Alphaproteobacteria,1JQI1@119043|Rhodobiaceae	28211|Alphaproteobacteria	H	Dihydroneopterin aldolase	-	-	1.13.11.81,4.1.2.25,5.1.99.8	ko:K01633	ko00790,ko01100,map00790,map01100	M00126,M00840	R03504,R11037,R11073	RC00721,RC00943,RC01479,RC03333,RC03334	ko00000,ko00001,ko00002,ko01000	-	-	-	FolB
SHD2_k127_6674884_4	1333998.M2A_2468	2.882e-266	834.0	COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,2TT32@28211|Alphaproteobacteria,4BPGY@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	GO:0005575,GO:0005622,GO:0005623,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009380,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0032991,GO:0033554,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0071496,GO:1902494,GO:1905347,GO:1905348,GO:1990391	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
SHD2_k127_6674884_76	744980.TRICHSKD4_2866	8.084e-45	169.0	COG0558@1|root,COG0558@2|Bacteria,1RCZ7@1224|Proteobacteria,2TUI7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA	-	2.7.8.41,2.7.8.5	ko:K00995,ko:K08744	ko00564,ko01100,map00564,map01100	-	R01801,R02030	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
SHD2_k127_6674884_102	1333998.M2A_2466	6.274e-20	96.0	COG1977@1|root,COG1977@2|Bacteria,1N0IE@1224|Proteobacteria,2UF4F@28211|Alphaproteobacteria,4BR44@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	H	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin	moaD	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
SHD2_k127_6674884_68	1122962.AULH01000019_gene297	1.788e-52	189.0	COG0314@1|root,COG0314@2|Bacteria,1RGUX@1224|Proteobacteria,2U73K@28211|Alphaproteobacteria,36YB6@31993|Methylocystaceae	28211|Alphaproteobacteria	H	MoaE protein	moaE	-	2.8.1.12	ko:K03635	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoaE
SHD2_k127_6674884_38	1298867.AUES01000003_gene1111	3.098e-108	355.0	COG0412@1|root,COG0412@2|Bacteria,1NRB4@1224|Proteobacteria,2TU91@28211|Alphaproteobacteria,3JUQK@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Dienelactone hydrolase family	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
SHD2_k127_6674884_91	395964.KE386496_gene410	1.081e-29	122.0	COG3753@1|root,COG3753@2|Bacteria,1N7FF@1224|Proteobacteria,2UFFP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Bacterial protein of unknown function (DUF937)	-	-	-	-	-	-	-	-	-	-	-	-	DUF937
SHD2_k127_6674884_112	1397666.RS24_01174	9.469e-10	65.0	2F81H@1|root,340EZ@2|Bacteria,1N5WY@1224|Proteobacteria,2UEF2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_6674884_33	1545915.JROG01000008_gene3489	2.146e-124	430.0	COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,2TTI2@28211|Alphaproteobacteria,2K0SD@204457|Sphingomonadales	204457|Sphingomonadales	P	COG1629 Outer membrane receptor proteins, mostly Fe transport	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
SHD2_k127_6674884_54	1230476.C207_03333	1.804e-74	258.0	COG1028@1|root,COG1028@2|Bacteria,1RBGC@1224|Proteobacteria,2U6FD@28211|Alphaproteobacteria,3JXHW@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
SHD2_k127_6674884_28	1333998.M2A_2464	7.626e-128	415.0	COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,2TR1H@28211|Alphaproteobacteria,4BPD3@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
SHD2_k127_6674884_65	1094553.MCS_00810	2.453e-58	211.0	COG0745@1|root,COG0745@2|Bacteria,1MY3D@1224|Proteobacteria,2TSQF@28211|Alphaproteobacteria,48TMQ@772|Bartonellaceae	28211|Alphaproteobacteria	KT	Transcriptional regulatory protein, C terminal	petR	-	-	ko:K07659	ko02020,ko02026,map02020,map02026	M00445,M00742,M00743	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
SHD2_k127_6674884_36	1282876.BAOK01000001_gene1231	2.891e-116	390.0	COG0642@1|root,COG2205@2|Bacteria,1MUAK@1224|Proteobacteria,2TQRE@28211|Alphaproteobacteria,4BPHP@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	envZ	-	2.7.13.3	ko:K07638	ko02020,ko02026,map02020,map02026	M00445,M00742,M00743	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
SHD2_k127_6674884_90	204669.Acid345_1457	3.823e-31	126.0	COG1917@1|root,COG1917@2|Bacteria	2|Bacteria	L	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
SHD2_k127_6674884_57	1150469.RSPPHO_03104	9.563e-67	237.0	COG0345@1|root,COG0345@2|Bacteria,1R5J1@1224|Proteobacteria,2TTY7@28211|Alphaproteobacteria,2JPQN@204441|Rhodospirillales	204441|Rhodospirillales	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	-	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_oxidored,P5CR_dimer
SHD2_k127_6674884_105	709797.CSIRO_0219	1.415e-16	86.0	COG2960@1|root,COG2960@2|Bacteria,1N725@1224|Proteobacteria,2UFEP@28211|Alphaproteobacteria,3K0BI@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Membrane fusogenic activity	MA20_05375	-	-	ko:K09806	-	-	-	-	ko00000	-	-	-	BMFP
SHD2_k127_6674884_42	1041147.AUFB01000005_gene2497	4.865e-91	311.0	COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,2TTNS@28211|Alphaproteobacteria,4B8EB@82115|Rhizobiaceae	28211|Alphaproteobacteria	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
SHD2_k127_6674884_39	1120983.KB894572_gene3022	1.285e-100	342.0	COG1565@1|root,COG1565@2|Bacteria,1N3CJ@1224|Proteobacteria,2TRHW@28211|Alphaproteobacteria,1JN7W@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Putative S-adenosyl-L-methionine-dependent methyltransferase	MA20_05390	-	2.1.1.79	ko:K00574,ko:K18164	ko04714,map04714	-	-	-	ko00000,ko00001,ko01000,ko03029	-	-	-	Methyltransf_28
SHD2_k127_6674884_47	1333998.M2A_2453	1.222e-78	273.0	COG1496@1|root,COG1496@2|Bacteria,1MW2H@1224|Proteobacteria,2TTXU@28211|Alphaproteobacteria,4BQ40@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Belongs to the multicopper oxidase YfiH RL5 family	yfiH	-	-	ko:K05810	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_4
SHD2_k127_6674884_15	402881.Plav_2258	5.04e-153	489.0	COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,2TR4Y@28211|Alphaproteobacteria,1JNIQ@119043|Rhodobiaceae	28211|Alphaproteobacteria	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran,Pribosyltran_N
SHD2_k127_6674884_26	1205680.CAKO01000002_gene2127	9.866e-131	427.0	COG2141@1|root,COG2141@2|Bacteria,1MUTJ@1224|Proteobacteria,2TTZI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
SHD2_k127_6674884_120	1245469.S58_04490	0.0007445	47.0	COG3801@1|root,COG3801@2|Bacteria,1REJV@1224|Proteobacteria,2UEVT@28211|Alphaproteobacteria,3K0SP@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	YjbR	-	-	-	-	-	-	-	-	-	-	-	-	YjbR
SHD2_k127_6674884_55	1236902.ANAS01000022_gene1	3.111e-74	257.0	COG1794@1|root,COG1794@2|Bacteria,2H7J9@201174|Actinobacteria,4EKYH@85012|Streptosporangiales	201174|Actinobacteria	M	Asp/Glu/Hydantoin racemase	-	-	5.1.1.13	ko:K01779	ko00250,ko01054,map00250,map01054	-	R00491	RC00302	ko00000,ko00001,ko01000	-	-	-	Asp_Glu_race
SHD2_k127_6674884_53	196367.JNFG01000019_gene4465	8.708e-75	260.0	COG0657@1|root,COG0657@2|Bacteria,1N2XW@1224|Proteobacteria,2VIBB@28216|Betaproteobacteria,1K23I@119060|Burkholderiaceae	28216|Betaproteobacteria	I	PFAM Alpha beta hydrolase fold-3 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3
SHD2_k127_6674884_60	395964.KE386496_gene1744	9.614e-62	222.0	COG1825@1|root,COG1825@2|Bacteria,1RDH0@1224|Proteobacteria,2U5P0@28211|Alphaproteobacteria,3N9XV@45404|Beijerinckiaceae	28211|Alphaproteobacteria	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
SHD2_k127_6674884_52	1282876.BAOK01000001_gene1220	3.402e-75	257.0	COG0193@1|root,COG0193@2|Bacteria,1MX1P@1224|Proteobacteria,2TT6Q@28211|Alphaproteobacteria,4BQ8B@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	GO:0003674,GO:0003824,GO:0004045,GO:0016787,GO:0016788,GO:0052689,GO:0140098,GO:0140101	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
SHD2_k127_6674884_12	1304877.KI519399_gene3199	8.825e-176	557.0	COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,2TRAD@28211|Alphaproteobacteria,3JRUC@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0044424,GO:0044464	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
SHD2_k127_6674884_45	1112212.JH584235_gene1460	5.696e-84	285.0	COG0412@1|root,COG0412@2|Bacteria,1MW7S@1224|Proteobacteria,2TTPH@28211|Alphaproteobacteria,2KDGA@204457|Sphingomonadales	204457|Sphingomonadales	Q	Dienelactone hydrolase family	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
SHD2_k127_6674884_84	1144310.PMI07_004955	5.563e-33	131.0	COG2827@1|root,COG2827@2|Bacteria,1MZME@1224|Proteobacteria,2UCNX@28211|Alphaproteobacteria,4BGCZ@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	GIY-YIG catalytic domain	-	-	-	ko:K07461	-	-	-	-	ko00000	-	-	-	GIY-YIG
SHD2_k127_6674884_1	1244869.H261_02286	3.25e-312	970.0	COG1028@1|root,COG3347@1|root,COG1028@2|Bacteria,COG3347@2|Bacteria,1MWSB@1224|Proteobacteria,2TSSM@28211|Alphaproteobacteria,2JR62@204441|Rhodospirillales	204441|Rhodospirillales	IQ	Class II Aldolase and Adducin N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Aldolase_II,adh_short_C2
SHD2_k127_6674884_17	1121861.KB899910_gene860	1.083e-149	485.0	COG0182@1|root,COG0182@2|Bacteria,1MUPM@1224|Proteobacteria,2TSPP@28211|Alphaproteobacteria,2JQQJ@204441|Rhodospirillales	204441|Rhodospirillales	E	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	mtnA	-	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	-	IF-2B
SHD2_k127_6674884_73	1532557.JL37_22225	3.142e-47	176.0	COG0625@1|root,COG0625@2|Bacteria,1RHSK@1224|Proteobacteria,2VRHW@28216|Betaproteobacteria,3T3MY@506|Alcaligenaceae	28216|Betaproteobacteria	O	Glutathione S-transferase	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C_2,GST_N_3
SHD2_k127_6674884_51	314254.OA2633_06559	9.26e-76	258.0	COG0503@1|root,COG0503@2|Bacteria,1MVZ6@1224|Proteobacteria,2TV7J@28211|Alphaproteobacteria,43XDS@69657|Hyphomonadaceae	28211|Alphaproteobacteria	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	apt	-	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
SHD2_k127_6674884_27	402881.Plav_2245	1.804e-128	417.0	COG0005@1|root,COG0005@2|Bacteria,1MUWW@1224|Proteobacteria,2TSN3@28211|Alphaproteobacteria,1JPHT@119043|Rhodobiaceae	28211|Alphaproteobacteria	F	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates	mtnP	-	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
SHD2_k127_6674884_72	1235457.C404_14325	1.57e-47	192.0	COG4122@1|root,COG4122@2|Bacteria,1PHWM@1224|Proteobacteria,2W7TM@28216|Betaproteobacteria,1KF47@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Macrocin-O-methyltransferase (TylF)	-	-	-	-	-	-	-	-	-	-	-	-	TylF
SHD2_k127_6674884_46	666684.AfiDRAFT_2969	3.938e-81	285.0	COG1290@1|root,COG2857@1|root,COG1290@2|Bacteria,COG2857@2|Bacteria,1MV97@1224|Proteobacteria,2TSZ3@28211|Alphaproteobacteria,3JUWH@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	petB	-	-	ko:K00410,ko:K00412	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko03029	-	-	-	Cytochrom_B_C,Cytochrom_C1,Cytochrome_B
SHD2_k127_6674884_10	1397666.RS24_01102	7.653e-185	588.0	COG1290@1|root,COG1290@2|Bacteria,1MV97@1224|Proteobacteria,2TSZ3@28211|Alphaproteobacteria,4BPD0@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	petB	-	-	ko:K00410,ko:K00412	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko03029	-	-	-	Cytochrom_B_C,Cytochrom_C1,Cytochrome_B
SHD2_k127_6674884_49	1333998.M2A_2437	4.551e-78	264.0	COG0723@1|root,COG0723@2|Bacteria,1RAA2@1224|Proteobacteria,2TTT2@28211|Alphaproteobacteria,4BQ3Z@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	petA	-	1.10.2.2	ko:K00411	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	Rieske,UCR_Fe-S_N
SHD2_k127_6674884_67	1121033.AUCF01000004_gene4935	4.615e-53	191.0	COG0219@1|root,COG0219@2|Bacteria,1RCY4@1224|Proteobacteria,2U78W@28211|Alphaproteobacteria,2JSWC@204441|Rhodospirillales	204441|Rhodospirillales	J	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide	trmL	-	2.1.1.207	ko:K03216	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
SHD2_k127_6674884_37	570952.ATVH01000013_gene3038	6.919e-116	381.0	COG0408@1|root,COG0408@2|Bacteria,1MWMF@1224|Proteobacteria,2TQNC@28211|Alphaproteobacteria,2JR26@204441|Rhodospirillales	204441|Rhodospirillales	H	Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX	hemF	-	1.3.3.3	ko:K00228	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03220	RC00884	ko00000,ko00001,ko00002,ko01000	-	-	-	Coprogen_oxidas
SHD2_k127_6674884_63	1287116.X734_18750	6.433e-59	211.0	COG0861@1|root,COG0861@2|Bacteria,1PN8B@1224|Proteobacteria,2TUV5@28211|Alphaproteobacteria,43H27@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	PFAM Integral membrane protein TerC	terC	-	-	-	-	-	-	-	-	-	-	-	TerC
SHD2_k127_6674884_82	1120983.KB894570_gene1636	1.618e-36	149.0	COG0631@1|root,COG0631@2|Bacteria,1NQ5H@1224|Proteobacteria,2UTUF@28211|Alphaproteobacteria,1JQ9W@119043|Rhodobiaceae	28211|Alphaproteobacteria	T	Protein phosphatase 2C	-	-	-	-	-	-	-	-	-	-	-	-	PP2C_2
SHD2_k127_6674884_19	402881.Plav_2237	1.188e-141	465.0	COG0617@1|root,COG0617@2|Bacteria,1MVCS@1224|Proteobacteria,2TRPZ@28211|Alphaproteobacteria,1JNDK@119043|Rhodobiaceae	28211|Alphaproteobacteria	J	Probable RNA and SrmB- binding site of polymerase A	pcnB	-	2.7.7.19,2.7.7.72	ko:K00970,ko:K00974	ko03013,ko03018,map03013,map03018	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	PolyA_pol,PolyA_pol_RNAbd
SHD2_k127_6674884_118	1502851.FG93_04176	0.0004643	49.0	2CETE@1|root,32ZH4@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_6674884_69	1333998.M2A_2430	1.505e-49	186.0	COG1051@1|root,COG1051@2|Bacteria,1QZRE@1224|Proteobacteria,2TYCS@28211|Alphaproteobacteria,4BTGI@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	F	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
SHD2_k127_6674884_58	1382303.JPOM01000001_gene1732	5.859e-65	231.0	COG3816@1|root,COG3816@2|Bacteria,1RD5Q@1224|Proteobacteria,2U7DA@28211|Alphaproteobacteria,2KGGT@204458|Caulobacterales	204458|Caulobacterales	S	Protein of unknown function (DUF1285)	-	-	-	ko:K09986	-	-	-	-	ko00000	-	-	-	DUF1285
SHD2_k127_6674884_30	648757.Rvan_3687	4.025e-127	415.0	COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,2TR0T@28211|Alphaproteobacteria,3N6FK@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	ATPase AAA	moxR	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
SHD2_k127_6674884_50	1150469.RSPPHO_01163	6.429e-78	274.0	COG1721@1|root,COG1721@2|Bacteria,1MWPG@1224|Proteobacteria,2TTDX@28211|Alphaproteobacteria,2JPHZ@204441|Rhodospirillales	204441|Rhodospirillales	S	conserved protein (some members contain a von Willebrand factor type A (vWA) domain)	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
SHD2_k127_6674884_5	402881.Plav_2232	1.892e-264	842.0	28H8H@1|root,2Z7KE@2|Bacteria,1MV77@1224|Proteobacteria,2TSVV@28211|Alphaproteobacteria,1JNEH@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Aerotolerance regulator N-terminal	MA20_44655	-	-	-	-	-	-	-	-	-	-	-	BatA,DUF4159
SHD2_k127_6674884_6	402881.Plav_2231	3.697e-228	728.0	COG5426@1|root,COG5426@2|Bacteria,1MVWA@1224|Proteobacteria,2TQNQ@28211|Alphaproteobacteria,1JNFN@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	membrane	MA20_44660	-	-	-	-	-	-	-	-	-	-	-	GATase1_like
SHD2_k127_6674884_79	1333998.M2A_2424	1.196e-41	171.0	COG3153@1|root,COG3153@2|Bacteria,1RD0C@1224|Proteobacteria,2U7AS@28211|Alphaproteobacteria,4BSQG@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_9
SHD2_k127_6674884_23	1282876.BAOK01000001_gene1194	5.535e-136	456.0	COG1028@1|root,COG1028@2|Bacteria,1MXNQ@1224|Proteobacteria,2TS6G@28211|Alphaproteobacteria	28211|Alphaproteobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	MA20_16310	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
SHD2_k127_6674884_35	1207058.L53_00160	2.204e-117	385.0	COG1028@1|root,COG1028@2|Bacteria,1MXNQ@1224|Proteobacteria,2TS6G@28211|Alphaproteobacteria,43X6G@69657|Hyphomonadaceae	28211|Alphaproteobacteria	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	MA20_16310	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
SHD2_k127_6674884_94	1207058.L53_00635	2.37e-24	108.0	COG1051@1|root,COG1051@2|Bacteria,1N0YW@1224|Proteobacteria,2UC2E@28211|Alphaproteobacteria,43ZVA@69657|Hyphomonadaceae	28211|Alphaproteobacteria	F	Belongs to the Nudix hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
SHD2_k127_6674884_71	1035191.HMPREF0185_02969	3.599e-48	180.0	COG0784@1|root,COG0784@2|Bacteria,1N0NS@1224|Proteobacteria,2TV2S@28211|Alphaproteobacteria,2KGN1@204458|Caulobacterales	204458|Caulobacterales	T	chemotaxis protein	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
SHD2_k127_6674884_116	1333998.M2A_2410	0.0001243	51.0	2DX5U@1|root,343H7@2|Bacteria,1P388@1224|Proteobacteria,2UUCZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_6674884_25	450851.PHZ_c3123	6.326e-131	423.0	COG1291@1|root,COG1291@2|Bacteria,1MXK3@1224|Proteobacteria,2TR5A@28211|Alphaproteobacteria,2KF09@204458|Caulobacterales	204458|Caulobacterales	N	With MotB forms the ion channels that couple flagellar rotation to proton sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine	-	-	-	ko:K02556	ko02020,ko02030,ko02040,map02020,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotA_ExbB
SHD2_k127_6674884_115	380394.Lferr_0219	2.063e-06	53.0	COG3462@1|root,COG3462@2|Bacteria,1QD7Z@1224|Proteobacteria,1T955@1236|Gammaproteobacteria,2NDWN@225057|Acidithiobacillales	225057|Acidithiobacillales	S	membrane protein (DUF2078)	-	-	-	ko:K08982	-	-	-	-	ko00000	-	-	-	-
SHD2_k127_6674884_7	1123020.AUIE01000003_gene551	9.315e-220	692.0	COG1012@1|root,COG1012@2|Bacteria,1MW72@1224|Proteobacteria,1RY9G@1236|Gammaproteobacteria,1YFJ9@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	C	Aldehyde dehydrogenase family	pcd	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
SHD2_k127_6674884_119	713587.THITH_09705	0.000672	51.0	COG3904@1|root,COG3904@2|Bacteria,1RK0H@1224|Proteobacteria,1SI4M@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	periplasmic protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_6674884_13	316057.RPD_3374	1.745e-175	575.0	COG0421@1|root,COG0421@2|Bacteria,1N1PJ@1224|Proteobacteria,2TUJQ@28211|Alphaproteobacteria,3JSDN@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	MA20_01900	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_6674884_16	1121033.AUCF01000008_gene5678	3.492e-150	484.0	COG1748@1|root,COG1748@2|Bacteria,1MY1G@1224|Proteobacteria,2TU0J@28211|Alphaproteobacteria,2JQ81@204441|Rhodospirillales	204441|Rhodospirillales	E	Saccharopine dehydrogenase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP
SHD2_k127_6674884_83	1279038.KB907341_gene1925	3.086e-33	136.0	COG1522@1|root,COG1522@2|Bacteria,1RH53@1224|Proteobacteria,2U9NS@28211|Alphaproteobacteria,2JTC9@204441|Rhodospirillales	204441|Rhodospirillales	K	helix_turn_helix ASNC type	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_AsnC-type
SHD2_k127_6674884_97	1166948.JPZL01000004_gene74	1.887e-23	115.0	COG4252@1|root,COG4252@2|Bacteria,1N7YK@1224|Proteobacteria	1224|Proteobacteria	T	Transmembrane sensor domain	-	-	-	-	-	-	-	-	-	-	-	-	CHASE2
SHD2_k127_6674884_109	929562.Emtol_2542	6.524e-12	78.0	COG4783@1|root,COG4783@2|Bacteria,4NEF9@976|Bacteroidetes,47XXI@768503|Cytophagia	976|Bacteroidetes	S	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
SHD2_k127_6674884_21	414684.RC1_3167	5.11e-138	451.0	COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,2TQN9@28211|Alphaproteobacteria,2JPM3@204441|Rhodospirillales	204441|Rhodospirillales	E	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA	ilvA	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,ACT_4,PALP
SHD2_k127_6674884_114	452652.KSE_24900	8.032e-07	55.0	COG3801@1|root,COG3801@2|Bacteria,2IHXB@201174|Actinobacteria,2M3I2@2063|Kitasatospora	201174|Actinobacteria	S	YjbR	-	-	-	-	-	-	-	-	-	-	-	-	YjbR
SHD2_k127_6674884_89	710686.Mycsm_01211	3.397e-31	129.0	COG0346@1|root,COG0346@2|Bacteria,2IQE0@201174|Actinobacteria,23AH8@1762|Mycobacteriaceae	201174|Actinobacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
SHD2_k127_6674884_96	452637.Oter_3023	1.013e-23	105.0	COG0346@1|root,COG0346@2|Bacteria,46WU7@74201|Verrucomicrobia	74201|Verrucomicrobia	C	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
SHD2_k127_6674884_85	867903.ThesuDRAFT_01113	7.847e-33	133.0	COG0300@1|root,COG0300@2|Bacteria,1VANI@1239|Firmicutes,251YZ@186801|Clostridia	186801|Clostridia	S	oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_6674884_18	34007.IT40_11510	1.507e-145	470.0	COG0482@1|root,COG0482@2|Bacteria,1MUT1@1224|Proteobacteria,2TQU7@28211|Alphaproteobacteria,2PV4H@265|Paracoccus	28211|Alphaproteobacteria	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
SHD2_k127_6674884_113	1399774.JDWH01000013_gene767	2.636e-07	62.0	COG1344@1|root,COG1344@2|Bacteria,1PJUJ@1224|Proteobacteria,1RPNR@1236|Gammaproteobacteria,3X19J@547|Enterobacter	1236|Gammaproteobacteria	N	TIGRFAM Flagellar hook-associated protein 3	flgL	GO:0005575,GO:0005576,GO:0005623,GO:0009288,GO:0042995,GO:0043226,GO:0043228,GO:0044464	-	ko:K02397	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_C,Flagellin_N
SHD2_k127_6674884_31	1161401.ASJA01000003_gene2889	1.807e-125	430.0	COG1256@1|root,COG1256@2|Bacteria,1MV2M@1224|Proteobacteria,2TV1B@28211|Alphaproteobacteria,43WWY@69657|Hyphomonadaceae	28211|Alphaproteobacteria	N	Belongs to the flagella basal body rod proteins family	flgK	-	-	ko:K02396	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
SHD2_k127_6674884_100	883080.HMPREF9697_03830	1.012e-21	110.0	COG3144@1|root,COG3144@2|Bacteria,1N7X4@1224|Proteobacteria,2UF9W@28211|Alphaproteobacteria,3JS1U@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	N	Flagellar hook-length control protein FliK	-	-	-	ko:K10565	-	-	-	-	ko00000,ko02035	-	-	-	Flg_hook
SHD2_k127_6674884_75	1380394.JADL01000011_gene4080	1.827e-45	173.0	COG1843@1|root,COG1843@2|Bacteria,1MXCG@1224|Proteobacteria,2UCHH@28211|Alphaproteobacteria,2JSP2@204441|Rhodospirillales	204441|Rhodospirillales	N	Required for flagellar hook formation. May act as a scaffolding protein	flgD	-	-	ko:K02389	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FLgD_tudor,FlgD,FlgD_ig
SHD2_k127_6674884_43	1161401.ASJA01000003_gene2892	2.052e-89	311.0	COG1749@1|root,COG1749@2|Bacteria,1MU5J@1224|Proteobacteria,2TSF2@28211|Alphaproteobacteria,43XST@69657|Hyphomonadaceae	28211|Alphaproteobacteria	N	Flagellar hook protein FlgE	flgE	-	-	ko:K02390	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlaE,Flg_bb_rod,Flg_bbr_C
SHD2_k127_6674884_77	402881.Plav_2185	5.297e-43	158.0	2AMHV@1|root,31CDG@2|Bacteria,1RGVA@1224|Proteobacteria,2U98Q@28211|Alphaproteobacteria,1JP99@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1153)	MA20_11245	-	-	-	-	-	-	-	-	-	-	-	DUF1153
SHD2_k127_6674884_29	402881.Plav_2184	9.431e-128	427.0	COG1766@1|root,COG1766@2|Bacteria,1MUQR@1224|Proteobacteria,2TR6J@28211|Alphaproteobacteria,1JNW5@119043|Rhodobiaceae	28211|Alphaproteobacteria	N	The M ring may be actively involved in energy transduction	fliF	-	-	ko:K02409	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	YscJ_FliF,YscJ_FliF_C
SHD2_k127_6674884_14	450851.PHZ_c0861	5.619e-156	499.0	COG1536@1|root,COG1536@2|Bacteria,1MV9X@1224|Proteobacteria,2TRIV@28211|Alphaproteobacteria,2KF0X@204458|Caulobacterales	204458|Caulobacterales	N	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation	fliG	-	-	ko:K02410	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliG_C,FliG_M,FliG_N
SHD2_k127_6674884_101	113395.AXAI01000001_gene3137	2.415e-20	99.0	COG1317@1|root,COG1317@2|Bacteria,1NSNC@1224|Proteobacteria,2TUID@28211|Alphaproteobacteria,3JUQR@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	NU	Flagellar assembly protein FliH	fliH	-	-	ko:K02411	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	FliH
SHD2_k127_6674884_80	402881.Plav_2181	1.97e-38	146.0	COG1886@1|root,COG1886@2|Bacteria,1RGWT@1224|Proteobacteria,2UC6U@28211|Alphaproteobacteria,1JPJB@119043|Rhodobiaceae	28211|Alphaproteobacteria	N	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation	fliN	GO:0005575,GO:0005623,GO:0005886,GO:0009288,GO:0009425,GO:0016020,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464,GO:0071944	-	ko:K02417	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	FliMN_C
SHD2_k127_6674884_9	1122962.AULH01000016_gene147	6.852e-201	634.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2TQPG@28211|Alphaproteobacteria,36XRE@31993|Methylocystaceae	28211|Alphaproteobacteria	T	Sigma-54 interaction domain	flbD	-	-	ko:K10943	ko02020,ko05111,map02020,map05111	M00515	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
SHD2_k127_6674884_2	402881.Plav_2179	8.241e-293	913.0	COG1298@1|root,COG1298@2|Bacteria,1MUF3@1224|Proteobacteria,2TQUR@28211|Alphaproteobacteria,1JN1Z@119043|Rhodobiaceae	28211|Alphaproteobacteria	N	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin	flhA	-	-	ko:K02400	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	FHIPEP
SHD2_k127_6674884_111	314345.SPV1_07746	7.689e-11	73.0	COG1419@1|root,COG1419@2|Bacteria,1MUQW@1224|Proteobacteria	1224|Proteobacteria	N	flagellar	flhF	-	-	ko:K02404	-	-	-	-	ko00000,ko02035	-	-	-	SRP54
SHD2_k127_6674884_70	570952.ATVH01000011_gene488	3.483e-48	183.0	COG0455@1|root,COG0455@2|Bacteria,1R8IW@1224|Proteobacteria,2TWWA@28211|Alphaproteobacteria,2JQPP@204441|Rhodospirillales	204441|Rhodospirillales	D	Belongs to the ParA family	-	-	-	ko:K04562	-	-	-	-	ko00000,ko02035	-	-	-	AAA_31,CbiA
SHD2_k127_6674884_61	1500259.JQLD01000005_gene537	2.229e-60	214.0	COG1704@1|root,COG1704@2|Bacteria,1MVH0@1224|Proteobacteria,2U6EM@28211|Alphaproteobacteria,4B7ZG@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	LemA family	lemA	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
SHD2_k127_6674884_22	1121448.DGI_3104	3.629e-137	460.0	COG4907@1|root,COG4907@2|Bacteria,1MXPY@1224|Proteobacteria,42MA5@68525|delta/epsilon subdivisions,2WJGZ@28221|Deltaproteobacteria,2M9Y5@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Predicted membrane protein (DUF2207)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2207
SHD2_k127_6674884_110	312153.Pnuc_1454	9.018e-12	71.0	COG2259@1|root,COG2259@2|Bacteria,1MZVP@1224|Proteobacteria,2VSDZ@28216|Betaproteobacteria,1K7WS@119060|Burkholderiaceae	28216|Betaproteobacteria	S	PFAM DoxX family protein	-	-	-	ko:K15977	-	-	-	-	ko00000	-	-	-	DoxX
SHD2_k127_6674884_103	1101192.KB910516_gene244	6.177e-19	91.0	2BAE2@1|root,323UI@2|Bacteria,1N2A8@1224|Proteobacteria,2UCBS@28211|Alphaproteobacteria,1JUIS@119045|Methylobacteriaceae	28211|Alphaproteobacteria	N	TIGRFAM flagellar export protein FliJ	fliJ	-	-	-	-	-	-	-	-	-	-	-	FliJ
SHD2_k127_6674884_11	1238182.C882_3413	4.11e-178	567.0	COG1157@1|root,COG1157@2|Bacteria,1MUH6@1224|Proteobacteria,2TRXU@28211|Alphaproteobacteria,2JPDY@204441|Rhodospirillales	204441|Rhodospirillales	NU	flagellum-specific ATP synthase	fliI	-	3.6.3.14	ko:K02412	ko02040,map02040	-	-	-	ko00000,ko00001,ko01000,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	ATP-synt_ab,ATP-synt_ab_N
SHD2_k127_6674884_32	1282876.BAOK01000001_gene1127	2.014e-125	404.0	COG0745@1|root,COG0745@2|Bacteria,1MWVI@1224|Proteobacteria,2TRSP@28211|Alphaproteobacteria,4BPAP@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	K	Transcriptional regulatory protein, C terminal	ctrA	GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141	-	ko:K02483,ko:K13584	ko02020,ko04112,map02020,map04112	M00512	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
SHD2_k127_6674884_64	402881.Plav_2097	8.93e-59	218.0	COG3386@1|root,COG3386@2|Bacteria,1RFF0@1224|Proteobacteria,2U8ZK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Arylesterase	-	-	-	-	-	-	-	-	-	-	-	-	Arylesterase
SHD2_k127_6674884_66	1174528.JH992898_gene3679	3.205e-56	201.0	COG0662@1|root,COG0662@2|Bacteria,1GAI7@1117|Cyanobacteria	1117|Cyanobacteria	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
SHD2_k127_6674884_8	1333998.M2A_3085	5.388e-205	654.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2TQMR@28211|Alphaproteobacteria,4BPW2@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	V	ABC transporter transmembrane region	msbA2	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
SHD2_k127_6674884_92	1125973.JNLC01000013_gene3863	1.013e-28	121.0	COG0254@1|root,COG0254@2|Bacteria,1MZ69@1224|Proteobacteria,2UBSC@28211|Alphaproteobacteria,3K03V@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	J	50S ribosomal protein L31	rpmE	-	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
SHD2_k127_6674884_44	536019.Mesop_4243	8.696e-88	294.0	COG3896@1|root,COG3896@2|Bacteria,1NTZF@1224|Proteobacteria,2UQ7C@28211|Alphaproteobacteria,43PTV@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	V	Chloramphenicol phosphotransferase-like protein	-	-	-	ko:K18554	-	-	-	-	br01600,ko00000,ko01000,ko01504	-	-	-	CPT
SHD2_k127_6674884_78	402881.Plav_2094	3.758e-42	160.0	COG5317@1|root,COG5317@2|Bacteria,1RJIA@1224|Proteobacteria,2U9ID@28211|Alphaproteobacteria,1JPE2@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1465)	MA20_18080	-	-	ko:K13592	ko04112,map04112	-	-	-	ko00000,ko00001	-	-	-	DUF1465
SHD2_k127_6674884_117	1123229.AUBC01000005_gene767	0.0003713	51.0	COG5509@1|root,COG5509@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1192)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1192
SHD2_k127_6674884_34	402881.Plav_2092	1.194e-117	387.0	COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,2TR1J@28211|Alphaproteobacteria,1JNNU@119043|Rhodobiaceae	28211|Alphaproteobacteria	C	Zinc-binding dehydrogenase	MA20_18095	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
SHD2_k127_6674884_99	1417296.U879_08140	1.678e-22	104.0	2DPKR@1|root,332JI@2|Bacteria,1QYH3@1224|Proteobacteria,2UIVV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_6674884_87	715226.ABI_07510	1.775e-32	128.0	2E9H4@1|root,333Q5@2|Bacteria,1N6SM@1224|Proteobacteria,2UGQ0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_6674884_48	402881.Plav_2090	1.38e-78	268.0	COG3820@1|root,COG3820@2|Bacteria,1MVR2@1224|Proteobacteria,2TT8Z@28211|Alphaproteobacteria,1JNNE@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1013)	MA20_20925	-	-	ko:K09987	-	-	-	-	ko00000	-	-	-	DUF1013
SHD2_k127_6674884_41	1089552.KI911559_gene1431	8.247e-95	325.0	COG0477@1|root,COG2814@2|Bacteria,1MVUF@1224|Proteobacteria,2TU4M@28211|Alphaproteobacteria,2JQ9V@204441|Rhodospirillales	204441|Rhodospirillales	EGP	COG0477 Permeases of the major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
SHD2_k127_6674884_62	1122962.AULH01000023_gene2997	9.131e-60	214.0	COG1238@1|root,COG1238@2|Bacteria,1MWED@1224|Proteobacteria,2U78A@28211|Alphaproteobacteria,36Y4R@31993|Methylocystaceae	28211|Alphaproteobacteria	S	DedA family	MA20_20865	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
SHD2_k127_6674884_3	1411123.JQNH01000001_gene2548	7.065e-272	849.0	COG0318@1|root,COG0318@2|Bacteria,1MUMC@1224|Proteobacteria,2TR96@28211|Alphaproteobacteria	28211|Alphaproteobacteria	IQ	COG0318, Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II	MA20_29420	-	6.2.1.48	ko:K00666,ko:K02182	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
SHD2_k127_6674884_104	861299.J421_6009	8.043e-18	84.0	2E328@1|root,32Y2G@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_6964799_13	1123059.KB823011_gene1434	1.14e-37	165.0	COG4625@1|root,COG4625@2|Bacteria,1N0PT@1224|Proteobacteria,2TTFH@28211|Alphaproteobacteria,43WEJ@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	Autotransporter beta-domain	-	-	-	-	-	-	-	-	-	-	-	-	Autotransporter
SHD2_k127_6964799_1	402777.KB235903_gene2616	8.82e-113	374.0	COG2008@1|root,COG2008@2|Bacteria,1G1VY@1117|Cyanobacteria,1H7SC@1150|Oscillatoriales	1117|Cyanobacteria	E	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde	-	-	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	-	R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
SHD2_k127_6964799_8	1040986.ATYO01000005_gene6344	9.323e-72	244.0	COG0346@1|root,COG0346@2|Bacteria,1RCYX@1224|Proteobacteria,2U7A8@28211|Alphaproteobacteria,43JP2@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Glyoxalase bleomycin resistance protein dioxygenase	gloA	GO:0003674,GO:0003824,GO:0004462,GO:0006518,GO:0006575,GO:0006749,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016846,GO:0034641,GO:0043603,GO:0044237,GO:0051186,GO:0071704,GO:1901564	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
SHD2_k127_6964799_16	397945.Aave_3311	2.326e-16	87.0	COG0810@1|root,COG0810@2|Bacteria,1MZPX@1224|Proteobacteria,2VM32@28216|Betaproteobacteria,4AD9Q@80864|Comamonadaceae	28216|Betaproteobacteria	M	TIGRFAM TonB family protein	tonB	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
SHD2_k127_6964799_9	1120919.AUBI01000010_gene117	2.102e-70	248.0	COG0811@1|root,COG0811@2|Bacteria,1NMPB@1224|Proteobacteria,2TVM9@28211|Alphaproteobacteria,2JRH9@204441|Rhodospirillales	204441|Rhodospirillales	U	TonB dependent biopolymer transporter integral cytoplasmic membrane subunit, working with ExbD	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
SHD2_k127_6964799_12	1123261.AXDW01000041_gene3641	2.949e-38	148.0	COG0848@1|root,COG0848@2|Bacteria,1RH4U@1224|Proteobacteria,1T1A3@1236|Gammaproteobacteria,1XAA7@135614|Xanthomonadales	135614|Xanthomonadales	U	Biopolymer transport protein ExbD/TolR	-	-	-	-	-	-	-	-	-	-	-	-	ExbD
SHD2_k127_6964799_11	1209072.ALBT01000012_gene3453	7.391e-44	163.0	COG0848@1|root,COG0848@2|Bacteria,1RHDF@1224|Proteobacteria,1SBHT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	U	Biopolymer transport protein ExbD/TolR	-	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
SHD2_k127_6964799_14	1123261.AXDW01000034_gene2118	2.539e-36	152.0	COG0457@1|root,COG0457@2|Bacteria,1Q7UR@1224|Proteobacteria,1T5SX@1236|Gammaproteobacteria,1XDF7@135614|Xanthomonadales	135614|Xanthomonadales	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_6964799_7	1123366.TH3_07832	1.989e-85	288.0	COG4149@1|root,COG4149@2|Bacteria,1MUXR@1224|Proteobacteria,2TSYJ@28211|Alphaproteobacteria,2JR2U@204441|Rhodospirillales	204441|Rhodospirillales	P	COG4149 ABC-type molybdate transport system, permease component	modB	-	-	ko:K02018	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	BPD_transp_1
SHD2_k127_6964799_4	1449350.OCH239_05950	2.764e-95	333.0	COG4148@1|root,COG4148@2|Bacteria,1MU8K@1224|Proteobacteria,2TR1Z@28211|Alphaproteobacteria,4KM2M@93682|Roseivivax	28211|Alphaproteobacteria	P	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system	modC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.6.3.29	ko:K02017	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.8	-	-	ABC_tran,TOBE
SHD2_k127_6964799_15	1336208.JADY01000012_gene2980	1.289e-19	101.0	COG2246@1|root,COG2246@2|Bacteria,1NJKI@1224|Proteobacteria,2UK14@28211|Alphaproteobacteria,2JYMD@204441|Rhodospirillales	204441|Rhodospirillales	S	GtrA-like protein	-	-	-	-	-	-	-	-	-	-	-	-	GtrA
SHD2_k127_6964799_0	1449076.JOOE01000001_gene2558	2.73e-116	382.0	COG1215@1|root,COG1215@2|Bacteria,1QU2F@1224|Proteobacteria,2U0P8@28211|Alphaproteobacteria,2K007@204457|Sphingomonadales	204457|Sphingomonadales	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
SHD2_k127_6964799_5	1121033.AUCF01000008_gene5722	5.524e-88	311.0	29RC6@1|root,30CE8@2|Bacteria,1R3PV@1224|Proteobacteria,2TYW8@28211|Alphaproteobacteria,2JUY8@204441|Rhodospirillales	204441|Rhodospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_6964799_2	667632.KB890198_gene1063	4.945e-107	362.0	COG0438@1|root,COG0438@2|Bacteria,1MUB7@1224|Proteobacteria,2VJ5X@28216|Betaproteobacteria,1K1CS@119060|Burkholderiaceae	28216|Betaproteobacteria	M	glycosyl transferase group 1	gtrA	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
SHD2_k127_6964799_3	1333998.M2A_2204	4.637e-103	342.0	COG2908@1|root,COG2908@2|Bacteria,1MVKD@1224|Proteobacteria,2TSEB@28211|Alphaproteobacteria,4BQ0H@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Calcineurin-like phosphoesterase superfamily domain	lpxH	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Metallophos_2
SHD2_k127_6964799_6	402881.Plav_1997	4.967e-86	294.0	COG3741@1|root,COG3741@2|Bacteria,1MY4D@1224|Proteobacteria,2TUPZ@28211|Alphaproteobacteria,1JN1M@119043|Rhodobiaceae	28211|Alphaproteobacteria	E	N-formylglutamate amidohydrolase	MA20_06380	-	3.5.1.68	ko:K01458	ko00340,ko00630,map00340,map00630	-	R00525	RC00165,RC00323	ko00000,ko00001,ko01000	-	-	-	FGase
SHD2_k127_6964799_10	1282876.BAOK01000001_gene965	1.112e-44	165.0	COG2204@1|root,COG2204@2|Bacteria,1RD1D@1224|Proteobacteria,2U76U@28211|Alphaproteobacteria,4BQQ2@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	T	cheY-homologous receiver domain	-	-	-	ko:K13589	ko02020,ko04112,map02020,map04112	M00512	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg
SHD2_k127_6964799_17	481448.Minf_1765	1.167e-08	64.0	COG0810@1|root,COG0810@2|Bacteria,46WPR@74201|Verrucomicrobia,37GSV@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	M	Gram-negative bacterial TonB protein C-terminal	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
SHD2_k127_6988077_5	1333998.M2A_1605	1.372e-09	65.0	2EHM8@1|root,33BD0@2|Bacteria,1NMMG@1224|Proteobacteria,2UJZ0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_6988077_2	1230476.C207_00562	5.673e-140	450.0	COG1024@1|root,COG1024@2|Bacteria,1MVPQ@1224|Proteobacteria,2TTJ4@28211|Alphaproteobacteria,3JSCJ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	enoyl-CoA hydratase	MA20_32365	-	-	-	-	-	-	-	-	-	-	-	ECH_1
SHD2_k127_6988077_4	573065.Astex_2628	1.297e-34	136.0	COG0789@1|root,COG0789@2|Bacteria,1RITY@1224|Proteobacteria,2U98M@28211|Alphaproteobacteria,2KGIY@204458|Caulobacterales	204458|Caulobacterales	K	Regulator	-	-	-	-	-	-	-	-	-	-	-	-	MerR,MerR-DNA-bind,MerR_1
SHD2_k127_6988077_0	1502851.FG93_04343	2.161e-184	595.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2TQND@28211|Alphaproteobacteria,3JQS8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.96	ko:K16871	ko00250,ko00650,ko01100,ko01120,map00250,map00650,map01100,map01120	M00027	R10178	RC00008,RC00062	ko00000,ko00001,ko00002,ko01000	-	-	-	Aminotran_3
SHD2_k127_6988077_3	1123269.NX02_13805	8.258e-40	156.0	COG0625@1|root,COG0625@2|Bacteria,1RD4X@1224|Proteobacteria,2U63J@28211|Alphaproteobacteria,2KD19@204457|Sphingomonadales	204457|Sphingomonadales	O	Glutathione S-transferase, C-terminal domain	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_N
SHD2_k127_6988077_1	1510531.JQJJ01000008_gene3768	3.287e-171	543.0	COG0500@1|root,COG0500@2|Bacteria,1N3PV@1224|Proteobacteria,2TVNH@28211|Alphaproteobacteria,3JUBW@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	O-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
SHD2_k127_7080119_45	414684.RC1_2014	3.885e-29	117.0	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,2TQZU@28211|Alphaproteobacteria,2JQ9C@204441|Rhodospirillales	204441|Rhodospirillales	F	Belongs to the CarB family	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
SHD2_k127_7080119_32	1382303.JPOM01000001_gene2594	3.127e-67	233.0	COG0782@1|root,COG0782@2|Bacteria,1RCXW@1224|Proteobacteria,2U5JU@28211|Alphaproteobacteria,2KGAN@204458|Caulobacterales	204458|Caulobacterales	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	-	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
SHD2_k127_7080119_21	402881.Plav_0111	1.251e-112	370.0	COG0745@1|root,COG0745@2|Bacteria,1MVCB@1224|Proteobacteria,2TR43@28211|Alphaproteobacteria,1JNCI@119043|Rhodobiaceae	28211|Alphaproteobacteria	T	Transcriptional regulatory protein, C terminal	chvI	GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141	-	ko:K14981	ko02020,map02020	M00520	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
SHD2_k127_7080119_13	1333998.M2A_0411	2.658e-144	474.0	COG0642@1|root,COG2205@2|Bacteria,1N17V@1224|Proteobacteria,2TS69@28211|Alphaproteobacteria,4BPE2@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	chvG	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.7.13.3	ko:K14980	ko02020,map02020	M00520	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,Sensor_TM1,Stimulus_sens_1
SHD2_k127_7080119_47	1120705.FG95_01395	1.174e-26	115.0	COG1493@1|root,COG1493@2|Bacteria,1NNN5@1224|Proteobacteria,2UFPB@28211|Alphaproteobacteria,2K65M@204457|Sphingomonadales	204457|Sphingomonadales	T	Serine kinase of the HPr protein, regulates carbohydrate metabolism	-	-	-	-	-	-	-	-	-	-	-	-	Hpr_kinase_C
SHD2_k127_7080119_40	1380394.JADL01000002_gene1650	1.538e-47	174.0	COG2893@1|root,COG2893@2|Bacteria,1RHH7@1224|Proteobacteria,2U9E5@28211|Alphaproteobacteria,2JS9V@204441|Rhodospirillales	204441|Rhodospirillales	G	COG2893 Phosphotransferase system, mannose fructose-specific component IIA	manX	-	2.7.1.191	ko:K02793	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	M00276	R02630	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.6.1	-	-	EIIA-man
SHD2_k127_7080119_50	1382303.JPOM01000001_gene2437	1.563e-20	100.0	COG1925@1|root,COG1925@2|Bacteria,1N6RM@1224|Proteobacteria,2UC0H@28211|Alphaproteobacteria,2KHC3@204458|Caulobacterales	204458|Caulobacterales	G	TIGRFAM phosphocarrier, HPr family	-	-	-	ko:K11189	-	-	-	-	ko00000,ko02000	4.A.2.1	-	-	PTS-HPr
SHD2_k127_7080119_48	1157490.EL26_15170	3.458e-23	108.0	COG0666@1|root,COG0666@2|Bacteria,1V657@1239|Firmicutes,4HIDE@91061|Bacilli	91061|Bacilli	S	Ankyrin repeat	-	-	-	-	-	-	-	-	-	-	-	-	Ank_2,Ank_4
SHD2_k127_7080119_2	1122132.AQYH01000005_gene562	3.164e-265	821.0	COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,2TSJY@28211|Alphaproteobacteria,4B88Y@82115|Rhizobiaceae	28211|Alphaproteobacteria	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
SHD2_k127_7080119_59	1504822.CCNO01000009_gene1704	0.0003497	47.0	COG0265@1|root,COG0265@2|Bacteria,2NNVS@2323|unclassified Bacteria	2|Bacteria	O	smart pdz dhr glgf	-	-	3.4.21.107	ko:K04771,ko:K08372	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
SHD2_k127_7080119_52	298653.Franean1_1638	2.581e-13	77.0	COG1633@1|root,COG1633@2|Bacteria	2|Bacteria	S	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)	-	-	-	-	-	-	-	-	-	-	-	-	Ferritin_2,Rhodanese,Rubrerythrin
SHD2_k127_7080119_38	243365.CV_2781	1.055e-49	185.0	COG3791@1|root,COG3791@2|Bacteria,1N023@1224|Proteobacteria,2WFT4@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Glutathione-dependent formaldehyde-activating enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GFA
SHD2_k127_7080119_9	1282876.BAOK01000001_gene3582	2.68e-169	560.0	COG0642@1|root,COG2205@2|Bacteria,1MVY8@1224|Proteobacteria,2TS5B@28211|Alphaproteobacteria,4BPC4@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	T	PAS fold	divL	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_7,PAS_8
SHD2_k127_7080119_11	685778.AORL01000004_gene3555	2.579e-155	503.0	COG3104@1|root,COG3104@2|Bacteria,1MW6W@1224|Proteobacteria,2U15C@28211|Alphaproteobacteria,2K2WX@204457|Sphingomonadales	204457|Sphingomonadales	E	amino acid peptide transporter	-	-	-	ko:K03305	-	-	-	-	ko00000	2.A.17	-	-	PTR2
SHD2_k127_7080119_41	450851.PHZ_c0215	1.229e-45	166.0	COG0633@1|root,COG0633@2|Bacteria,1RHDC@1224|Proteobacteria,2U97J@28211|Alphaproteobacteria,2KGS1@204458|Caulobacterales	204458|Caulobacterales	C	ferredoxin	-	-	-	ko:K04755	-	-	-	-	ko00000	-	-	-	Fer2
SHD2_k127_7080119_14	1280954.HPO_06758	5.229e-131	430.0	COG0446@1|root,COG0446@2|Bacteria,1NR3M@1224|Proteobacteria,2TS0K@28211|Alphaproteobacteria,43X2S@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	pyridine nucleotide-disulfide oxidoreductase	-	-	1.18.1.3	ko:K00529	ko00071,ko00360,ko01120,ko01220,map00071,map00360,map01120,map01220	M00545	R02000,R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	Pyr_redox_2,Reductase_C
SHD2_k127_7080119_42	1040986.ATYO01000007_gene1167	6.874e-40	153.0	COG0802@1|root,COG3178@1|root,COG0802@2|Bacteria,COG3178@2|Bacteria,1MXCH@1224|Proteobacteria,2TSJD@28211|Alphaproteobacteria,43ITI@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Threonylcarbamoyl adenosine biosynthesis protein TsaE	MA20_24090	-	2.7.1.221	ko:K07102	ko00520,ko01100,map00520,map01100	-	R08968,R11024	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	APH,TsaE
SHD2_k127_7080119_26	509190.Cseg_0150	2.02e-86	299.0	COG3178@1|root,COG3178@2|Bacteria,1MXCH@1224|Proteobacteria,2TSJD@28211|Alphaproteobacteria,2KEXH@204458|Caulobacterales	204458|Caulobacterales	S	Phosphotransferase	-	-	2.7.1.221	ko:K07102	ko00520,ko01100,map00520,map01100	-	R08968,R11024	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	APH
SHD2_k127_7080119_27	670307.HYPDE_34513	3.504e-86	291.0	COG1208@1|root,COG1208@2|Bacteria,1R9ZD@1224|Proteobacteria,2TU2V@28211|Alphaproteobacteria,3N734@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	JM	Nucleotidyl transferase	MA20_24100	-	2.7.7.13,2.7.7.99	ko:K00966,ko:K00992	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885,R11025	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transf_3,NTP_transferase
SHD2_k127_7080119_4	1333998.M2A_2813	1.193e-238	774.0	COG2887@1|root,COG3893@1|root,COG2887@2|Bacteria,COG3893@2|Bacteria,1MY2G@1224|Proteobacteria,2TS74@28211|Alphaproteobacteria,4BPCQ@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	L	PD-(D/E)XK nuclease superfamily	addB	-	3.6.4.12	ko:K16899	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	PDDEXK_1
SHD2_k127_7080119_0	402881.Plav_0138	4.216e-272	875.0	COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,2TQJZ@28211|Alphaproteobacteria,1JNE1@119043|Rhodobiaceae	28211|Alphaproteobacteria	L	PD-(D/E)XK nuclease superfamily	addA	-	3.6.4.12	ko:K16898	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
SHD2_k127_7080119_39	1333998.M2A_2815	3.974e-48	175.0	COG3118@1|root,COG3118@2|Bacteria,1MZBB@1224|Proteobacteria,2UCCR@28211|Alphaproteobacteria,4BQHB@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	O	Thioredoxin-like domain	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
SHD2_k127_7080119_12	402881.Plav_0140	5.02e-146	477.0	COG0285@1|root,COG0285@2|Bacteria,1MVCH@1224|Proteobacteria,2TR64@28211|Alphaproteobacteria,1JNBN@119043|Rhodobiaceae	28211|Alphaproteobacteria	H	Mur ligase middle domain	folC	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_M
SHD2_k127_7080119_20	1333998.M2A_2817	6.618e-115	378.0	COG0777@1|root,COG0777@2|Bacteria,1MW8G@1224|Proteobacteria,2TRSH@28211|Alphaproteobacteria,4BP8Z@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA	accD	-	2.1.3.15,6.4.1.2	ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
SHD2_k127_7080119_28	1121033.AUCF01000001_gene2002	5.25e-85	291.0	COG0159@1|root,COG0159@2|Bacteria,1MXJV@1224|Proteobacteria,2TQN2@28211|Alphaproteobacteria,2JPR3@204441|Rhodospirillales	204441|Rhodospirillales	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
SHD2_k127_7080119_6	1333998.M2A_2819	7.455e-203	638.0	COG0133@1|root,COG0133@2|Bacteria,1MUS8@1224|Proteobacteria,2TSHK@28211|Alphaproteobacteria,4BP9D@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	GO:0000162,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
SHD2_k127_7080119_35	395964.KE386496_gene2851	1.228e-59	213.0	COG0135@1|root,COG0135@2|Bacteria,1RA87@1224|Proteobacteria,2U7CH@28211|Alphaproteobacteria,3NAZS@45404|Beijerinckiaceae	28211|Alphaproteobacteria	E	N-(5'phosphoribosyl)anthranilate (PRA) isomerase	trpF	-	5.3.1.24	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03509	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	PRAI
SHD2_k127_7080119_29	1121033.AUCF01000005_gene5376	4.677e-75	258.0	COG0284@1|root,COG0284@2|Bacteria,1MW2C@1224|Proteobacteria,2TTB3@28211|Alphaproteobacteria,2JRPW@204441|Rhodospirillales	204441|Rhodospirillales	F	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)	pyrF	-	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
SHD2_k127_7080119_43	402881.Plav_0147	1.378e-38	147.0	COG0776@1|root,COG0776@2|Bacteria,1MZ7M@1224|Proteobacteria,2UBR5@28211|Alphaproteobacteria,1JPAN@119043|Rhodobiaceae	28211|Alphaproteobacteria	K	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control	himD	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009889,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2001141	-	ko:K05788	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
SHD2_k127_7080119_33	633149.Bresu_1199	6.097e-64	241.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2TSRP@28211|Alphaproteobacteria,2KFCY@204458|Caulobacterales	204458|Caulobacterales	T	Histidine kinase	divJ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.7.13.3	ko:K11357	ko02020,ko04112,map02020,map04112	M00511	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA
SHD2_k127_7080119_56	1089552.KI911559_gene888	1.913e-08	63.0	COG5388@1|root,COG5388@2|Bacteria,1N0UI@1224|Proteobacteria,2UCZU@28211|Alphaproteobacteria,2JTNR@204441|Rhodospirillales	204441|Rhodospirillales	S	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	PAS_5
SHD2_k127_7080119_3	402881.Plav_0149	2.756e-263	821.0	COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,2TQPV@28211|Alphaproteobacteria,1JNFM@119043|Rhodobiaceae	28211|Alphaproteobacteria	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
SHD2_k127_7080119_34	402881.Plav_0150	1.349e-63	228.0	COG0283@1|root,COG0283@2|Bacteria,1MUUD@1224|Proteobacteria,2U71H@28211|Alphaproteobacteria,1JNX4@119043|Rhodobiaceae	28211|Alphaproteobacteria	F	Cytidylate kinase	cmk	GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin
SHD2_k127_7080119_8	1415756.JQMY01000001_gene1689	2.587e-171	549.0	COG0128@1|root,COG0128@2|Bacteria,1MWMK@1224|Proteobacteria,2TR6W@28211|Alphaproteobacteria,2PD3U@252301|Oceanicola	28211|Alphaproteobacteria	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
SHD2_k127_7080119_51	314260.PB2503_12964	1.761e-15	85.0	COG4530@1|root,COG4530@2|Bacteria,1N85Z@1224|Proteobacteria,2UF7V@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (FYDLN_acid)	MA20_24185	-	-	-	-	-	-	-	-	-	-	-	FYDLN_acid
SHD2_k127_7080119_57	1247024.JRLH01000002_gene196	3.652e-08	55.0	2DT3B@1|root,33IHT@2|Bacteria,1NK4F@1224|Proteobacteria,1SHSY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_7080119_31	1254432.SCE1572_02010	4.548e-69	243.0	COG3482@1|root,COG3482@2|Bacteria,1QG2J@1224|Proteobacteria,43BG1@68525|delta/epsilon subdivisions,2X6UC@28221|Deltaproteobacteria,2Z3CU@29|Myxococcales	28221|Deltaproteobacteria	S	TfuA-like protein	-	-	-	-	-	-	-	-	-	-	-	-	TfuA
SHD2_k127_7080119_23	1242864.D187_003605	4.182e-100	340.0	COG1944@1|root,COG1944@2|Bacteria,1N5NV@1224|Proteobacteria,42VNR@68525|delta/epsilon subdivisions,2WSCG@28221|Deltaproteobacteria,2YXER@29|Myxococcales	28221|Deltaproteobacteria	S	YcaO cyclodehydratase, ATP-ad Mg2+-binding	-	-	-	ko:K09136	-	-	-	-	ko00000,ko03009	-	-	-	YcaO
SHD2_k127_7080119_15	1297570.MESS4_740025	7.77e-128	430.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,43JWG@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,TPR_16,TPR_19,TPR_8
SHD2_k127_7080119_18	402881.Plav_1858	1.747e-118	398.0	COG2303@1|root,COG2303@2|Bacteria,1MU3F@1224|Proteobacteria,2TT3C@28211|Alphaproteobacteria,1JPG1@119043|Rhodobiaceae	28211|Alphaproteobacteria	E	GMC oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO,FAD_binding_2,GMC_oxred_C,GMC_oxred_N,NAD_binding_8
SHD2_k127_7080119_10	1500893.JQNB01000001_gene1333	2.859e-167	546.0	COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,1RMSE@1236|Gammaproteobacteria,1X6S1@135614|Xanthomonadales	135614|Xanthomonadales	EH	chorismate binding enzyme	-	-	2.6.1.85	ko:K13950	ko00790,map00790	-	R01716	RC00010,RC01418	ko00000,ko00001,ko01000	-	-	-	Aminotran_4,Anth_synt_I_N,Chorismate_bind,GATase
SHD2_k127_7080119_37	402881.Plav_0188	2.674e-51	185.0	COG0071@1|root,COG0071@2|Bacteria,1R9Y1@1224|Proteobacteria,2UA1J@28211|Alphaproteobacteria,1JP3W@119043|Rhodobiaceae	28211|Alphaproteobacteria	O	Hsp20/alpha crystallin family	hspH	-	-	ko:K04080	-	-	-	-	ko00000,ko03110	-	-	-	HSP20
SHD2_k127_7080119_53	663610.JQKO01000023_gene519	4.917e-10	64.0	COG5568@1|root,COG5568@2|Bacteria,1N9BT@1224|Proteobacteria,2UFNF@28211|Alphaproteobacteria,3NBS3@45404|Beijerinckiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1150)	MA20_24245	-	-	-	-	-	-	-	-	-	-	-	DUF1150
SHD2_k127_7080119_19	113395.AXAI01000010_gene2113	8.913e-116	380.0	COG1028@1|root,COG1028@2|Bacteria,1MX8B@1224|Proteobacteria,2U26N@28211|Alphaproteobacteria,3JR5Z@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IQ	KR domain	MA20_18145	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
SHD2_k127_7080119_36	1333998.M2A_1873	1.977e-56	201.0	COG1762@1|root,COG1762@2|Bacteria,1RD0E@1224|Proteobacteria,2U7B0@28211|Alphaproteobacteria,4BQX6@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	GT	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2	ptsN	-	-	ko:K02806	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	PTS_EIIA_2
SHD2_k127_7080119_49	1397666.RS24_01778	1.089e-21	101.0	COG1544@1|root,COG1544@2|Bacteria,1MZHW@1224|Proteobacteria,2TV3J@28211|Alphaproteobacteria,4BQR2@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	J	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase	hpf	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006417,GO:0006448,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0017148,GO:0019222,GO:0022626,GO:0022627,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0043021,GO:0043022,GO:0043024,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:1990904,GO:2000112,GO:2000113	-	ko:K05808	-	-	-	-	ko00000,ko03009	-	-	-	Ribosom_S30AE_C,Ribosomal_S30AE
SHD2_k127_7080119_7	450851.PHZ_c0178	4.424e-175	563.0	COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,2TS41@28211|Alphaproteobacteria,2KFNY@204458|Caulobacterales	204458|Caulobacterales	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	rpoN	-	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
SHD2_k127_7080119_17	1207063.P24_06726	4.21e-119	387.0	COG1137@1|root,COG1137@2|Bacteria,1MU8M@1224|Proteobacteria,2TR7F@28211|Alphaproteobacteria,2JPX9@204441|Rhodospirillales	204441|Rhodospirillales	S	ABC transporter, ATP-binding protein	lptB	-	-	ko:K06861	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	1.B.42.1	-	-	ABC_tran,BCA_ABC_TP_C
SHD2_k127_7080119_54	1282876.BAOK01000001_gene3420	6.397e-10	68.0	COG1934@1|root,COG1934@2|Bacteria,1MXGA@1224|Proteobacteria,2U6DD@28211|Alphaproteobacteria,4BQYU@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	OstA-like protein	lptA	-	-	ko:K09774	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA
SHD2_k127_7080119_44	402881.Plav_0195	4.413e-32	134.0	COG5375@1|root,COG5375@2|Bacteria,1Q5QB@1224|Proteobacteria,2VCFG@28211|Alphaproteobacteria,1JPH7@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Lipopolysaccharide-assembly, LptC-related	-	-	-	ko:K11719	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	LptC
SHD2_k127_7080119_22	1121033.AUCF01000003_gene3166	7.207e-112	370.0	COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,1MUXD@1224|Proteobacteria,2TU5X@28211|Alphaproteobacteria,2JPK0@204441|Rhodospirillales	204441|Rhodospirillales	M	Belongs to the SIS family. GutQ KpsF subfamily	kpsF	-	5.3.1.13	ko:K06041	ko00540,ko01100,map00540,map01100	M00063	R01530	RC00541	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CBS,SIS
SHD2_k127_7080119_25	1207063.P24_06741	8.651e-94	312.0	COG0349@1|root,COG0349@2|Bacteria,1MWFD@1224|Proteobacteria,2TQXS@28211|Alphaproteobacteria,2JQMC@204441|Rhodospirillales	204441|Rhodospirillales	J	3'-5' exonuclease	-	-	3.1.13.5	ko:K03684	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DNA_pol_A_exo1
SHD2_k127_7080119_30	1307761.L21SP2_0997	1.053e-69	252.0	COG0477@1|root,COG0477@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SHD2_k127_7080119_46	1536770.R50345_19875	5.579e-27	116.0	COG0454@1|root,COG0456@2|Bacteria,1UV77@1239|Firmicutes,4HVHY@91061|Bacilli,26XNG@186822|Paenibacillaceae	91061|Bacilli	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_7
SHD2_k127_7080119_1	622637.KE124774_gene3269	5.774e-267	841.0	COG0577@1|root,COG1136@1|root,COG0577@2|Bacteria,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,2TS3W@28211|Alphaproteobacteria,36ZXM@31993|Methylocystaceae	28211|Alphaproteobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003,ko:K05685	ko02010,map02010	M00258,M00709	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.122.1,3.A.1.122.12	-	-	ABC_tran,FtsX,MacB_PCD
SHD2_k127_7080119_16	622637.KE124774_gene3270	3.124e-124	411.0	COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,2U139@28211|Alphaproteobacteria,36ZXZ@31993|Methylocystaceae	28211|Alphaproteobacteria	M	HlyD family secretion protein	-	-	-	ko:K02005,ko:K13888	-	M00709	-	-	ko00000,ko00002,ko02000	8.A.1	-	-	Biotin_lipoyl_2,HlyD_D23
SHD2_k127_7080119_5	450851.PHZ_c0336	3.099e-221	700.0	COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,2TRC5@28211|Alphaproteobacteria,2KG6X@204458|Caulobacterales	204458|Caulobacterales	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	-	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger,TrkA_N
SHD2_k127_7080119_24	187272.Mlg_2362	2.967e-94	321.0	COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,1RMZQ@1236|Gammaproteobacteria,1WVY0@135613|Chromatiales	135613|Chromatiales	CE	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	-	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
SHD2_k127_7080119_55	114615.BRADO6695	1.14e-08	56.0	COG0393@1|root,COG0393@2|Bacteria,1N2F5@1224|Proteobacteria,2UDZU@28211|Alphaproteobacteria,3JZS1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Putative heavy-metal-binding	-	-	-	-	-	-	-	-	-	-	-	-	YbjQ_1
SHD2_k127_7190873_16	1382303.JPOM01000001_gene1483	6.75e-75	271.0	COG3746@1|root,COG3746@2|Bacteria,1RA39@1224|Proteobacteria,2U9KD@28211|Alphaproteobacteria,2KFTY@204458|Caulobacterales	204458|Caulobacterales	P	PFAM Phosphate-selective porin O and P	-	-	-	ko:K07221	-	-	-	-	ko00000,ko02000	1.B.5.1	-	-	Porin_O_P
SHD2_k127_7190873_6	1095769.CAHF01000011_gene2734	3.501e-139	452.0	COG1613@1|root,COG1613@2|Bacteria,1MUAU@1224|Proteobacteria,2VIQZ@28216|Betaproteobacteria,473AN@75682|Oxalobacteraceae	28216|Betaproteobacteria	P	Bacterial extracellular solute-binding protein	sbp	-	-	ko:K02048	ko00920,ko02010,map00920,map02010	M00185	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.1,3.A.1.6.3	-	-	SBP_bac_11
SHD2_k127_7190873_13	224914.BMEI1840	1.067e-100	341.0	COG0555@1|root,COG0555@2|Bacteria,1QTTU@1224|Proteobacteria,2TTET@28211|Alphaproteobacteria,1J228@118882|Brucellaceae	28211|Alphaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	cysT	-	-	ko:K02046	ko00920,ko02010,map00920,map02010	M00185	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.1,3.A.1.6.3	-	-	BPD_transp_1
SHD2_k127_7190873_10	1121033.AUCF01000011_gene1848	8.046e-123	404.0	COG4208@1|root,COG4208@2|Bacteria,1MV8X@1224|Proteobacteria,2TQR8@28211|Alphaproteobacteria,2JP94@204441|Rhodospirillales	204441|Rhodospirillales	P	sulfate transport system, permease	cysW	-	-	ko:K02047	ko00920,ko02010,map00920,map02010	M00185	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.1,3.A.1.6.3	-	-	BPD_transp_1
SHD2_k127_7190873_14	1379701.JPJC01000024_gene1794	3.85e-95	317.0	COG1118@1|root,COG1118@2|Bacteria,1QTTT@1224|Proteobacteria,2TVZ3@28211|Alphaproteobacteria,2KENV@204457|Sphingomonadales	204457|Sphingomonadales	P	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system	cysA	-	3.6.3.25	ko:K02045	ko00920,ko02010,map00920,map02010	M00185	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.6.1,3.A.1.6.3	-	-	ABC_tran
SHD2_k127_7190873_11	448385.sce0767	7.421e-103	342.0	COG1305@1|root,COG1305@2|Bacteria,1R9WH@1224|Proteobacteria	1224|Proteobacteria	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
SHD2_k127_7190873_17	864069.MicloDRAFT_00014220	6.143e-74	257.0	COG2207@1|root,COG3708@1|root,COG2207@2|Bacteria,COG3708@2|Bacteria,1MWTF@1224|Proteobacteria,2TTWC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	araC family	MA20_01270	-	-	ko:K13652,ko:K13653	-	-	-	-	ko00000,ko03000	-	-	-	GyrI-like,HTH_18
SHD2_k127_7190873_1	450851.PHZ_c3062	3.086e-201	641.0	COG0318@1|root,COG0318@2|Bacteria,1MUIC@1224|Proteobacteria,2TRRZ@28211|Alphaproteobacteria,2KF80@204458|Caulobacterales	28211|Alphaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
SHD2_k127_7190873_19	215803.DB30_6893	3.518e-62	228.0	COG2267@1|root,COG2267@2|Bacteria,1MVDA@1224|Proteobacteria,42RFJ@68525|delta/epsilon subdivisions,2WP11@28221|Deltaproteobacteria,2YUVM@29|Myxococcales	28221|Deltaproteobacteria	I	Protein of unknown function (DUF3089)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3089
SHD2_k127_7190873_22	1121861.KB899928_gene1484	2.005e-13	78.0	2DXYW@1|root,3478D@2|Bacteria,1P0ZZ@1224|Proteobacteria,2UMQ6@28211|Alphaproteobacteria,2JY7J@204441|Rhodospirillales	204441|Rhodospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_7190873_3	1381123.AYOD01000002_gene615	1.873e-177	567.0	COG1249@1|root,COG1249@2|Bacteria,1MU2Z@1224|Proteobacteria,2TQS7@28211|Alphaproteobacteria,43IAU@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family	gor	GO:0000166,GO:0000302,GO:0000305,GO:0003674,GO:0005488,GO:0005507,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009987,GO:0010035,GO:0017076,GO:0019725,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042221,GO:0042592,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0045454,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0065007,GO:0065008,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901700	1.8.1.7	ko:K00383	ko00480,ko04918,map00480,map04918	-	R00094,R00115	RC00011	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
SHD2_k127_7190873_21	56107.Cylst_0151	3.161e-29	131.0	COG4782@1|root,COG4782@2|Bacteria	2|Bacteria	P	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF900
SHD2_k127_7190873_18	323097.Nham_1480	3.135e-71	247.0	COG0120@1|root,COG0120@2|Bacteria,1MVGR@1224|Proteobacteria,2TU68@28211|Alphaproteobacteria,3JTM0@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate	rpiA	-	5.3.1.6	ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167,M00580	R01056	RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	Rib_5-P_isom_A
SHD2_k127_7190873_0	402881.Plav_3067	9.973e-253	793.0	COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,2TQPM@28211|Alphaproteobacteria,1JNJZ@119043|Rhodobiaceae	28211|Alphaproteobacteria	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
SHD2_k127_7190873_7	331869.BAL199_21494	2.325e-138	452.0	COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,2TQPS@28211|Alphaproteobacteria,4BPG8@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	-	2.3.1.157,2.7.7.23	ko:K04042,ko:K11528	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transf_3
SHD2_k127_7190873_20	1121123.AUAO01000003_gene2124	7.696e-50	186.0	COG0546@1|root,COG0546@2|Bacteria,1RDDY@1224|Proteobacteria,2U79T@28211|Alphaproteobacteria,2KGHI@204458|Caulobacterales	204458|Caulobacterales	G	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress	gph	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
SHD2_k127_7190873_2	1122604.JONR01000033_gene10	5.965e-199	627.0	COG2133@1|root,COG2133@2|Bacteria,1MVK5@1224|Proteobacteria,1RPE8@1236|Gammaproteobacteria,1X4AD@135614|Xanthomonadales	135614|Xanthomonadales	G	sorbosone dehydrogenase	sndH	-	-	-	-	-	-	-	-	-	-	-	GSDH
SHD2_k127_7190873_9	1449049.JONW01000008_gene452	2.622e-128	415.0	COG0788@1|root,COG0788@2|Bacteria,1MVCF@1224|Proteobacteria,2TR4V@28211|Alphaproteobacteria,2KFGR@204458|Caulobacterales	204458|Caulobacterales	F	Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4)	purU	-	3.5.1.10	ko:K01433	ko00630,ko00670,map00630,map00670	-	R00944	RC00026,RC00111	ko00000,ko00001,ko01000	-	-	-	ACT,Formyl_trans_N
SHD2_k127_7190873_15	483219.LILAB_00370	5.788e-82	278.0	COG0346@1|root,COG0346@2|Bacteria,1RAC9@1224|Proteobacteria,432ZG@68525|delta/epsilon subdivisions,2WXG3@28221|Deltaproteobacteria,2Z03C@29|Myxococcales	28221|Deltaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
SHD2_k127_7190873_5	1248916.ANFY01000007_gene2486	1.967e-162	519.0	COG0620@1|root,COG0620@2|Bacteria,1MUI9@1224|Proteobacteria,2TTWK@28211|Alphaproteobacteria,2K0DU@204457|Sphingomonadales	204457|Sphingomonadales	E	Methionine synthase	-	-	-	-	-	-	-	-	-	-	-	-	Meth_synt_2
SHD2_k127_7190873_12	1545915.JROG01000004_gene2619	9.703e-102	338.0	COG0372@1|root,COG0372@2|Bacteria,1MUII@1224|Proteobacteria,2TSDI@28211|Alphaproteobacteria,2K3T2@204457|Sphingomonadales	204457|Sphingomonadales	C	Citrate synthase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Citrate_synt
SHD2_k127_7190873_4	1007105.PT7_2248	2.262e-177	563.0	COG1804@1|root,COG1804@2|Bacteria,1P68A@1224|Proteobacteria,2VZJW@28216|Betaproteobacteria,3T72D@506|Alcaligenaceae	28216|Betaproteobacteria	C	CoA-transferase family III	-	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
SHD2_k127_7190873_8	1248917.ANFX01000040_gene770	2.451e-136	454.0	COG4774@1|root,COG4774@2|Bacteria,1NMCN@1224|Proteobacteria,2U1C8@28211|Alphaproteobacteria,2K3AZ@204457|Sphingomonadales	204457|Sphingomonadales	P	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
SHD2_k127_7234004_5	1333998.M2A_1884	6.158e-181	571.0	COG0821@1|root,COG0821@2|Bacteria,1MUAX@1224|Proteobacteria,2TQSI@28211|Alphaproteobacteria,4BP6J@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046429,GO:0046490,GO:0052592,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
SHD2_k127_7234004_25	402881.Plav_1745	8.615e-46	178.0	COG1426@1|root,COG1426@2|Bacteria,1MYWX@1224|Proteobacteria,2TQM2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	D	protein conserved in bacteria	-	-	-	ko:K15539	-	-	-	-	ko00000	-	-	-	DUF4115,HTH_25
SHD2_k127_7234004_3	460265.Mnod_0111	2.7e-247	785.0	COG3605@1|root,COG3605@2|Bacteria,1QTTV@1224|Proteobacteria,2TR3Z@28211|Alphaproteobacteria,1JS6M@119045|Methylobacteriaceae	28211|Alphaproteobacteria	T	Belongs to the PEP-utilizing enzyme family	ptsP	-	2.7.3.9	ko:K08484	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	GAF,GAF_2,PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
SHD2_k127_7234004_6	269796.Rru_A0743	5.693e-178	572.0	COG0527@1|root,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,2TRFA@28211|Alphaproteobacteria,2JPI1@204441|Rhodospirillales	204441|Rhodospirillales	E	Belongs to the aspartokinase family	lysC	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7
SHD2_k127_7234004_17	1382303.JPOM01000001_gene2433	3.864e-98	327.0	COG2227@1|root,COG2227@2|Bacteria,1MU89@1224|Proteobacteria,2TRIK@28211|Alphaproteobacteria,2KFT0@204458|Caulobacterales	204458|Caulobacterales	H	O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway	ubiG	-	2.1.1.222,2.1.1.64	ko:K00568	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11,Methyltransf_23
SHD2_k127_7234004_30	1123060.JONP01000005_gene5570	1.427e-33	140.0	COG2930@1|root,COG2930@2|Bacteria,1RHV6@1224|Proteobacteria,2U9N6@28211|Alphaproteobacteria,2JSQS@204441|Rhodospirillales	204441|Rhodospirillales	S	Las17-binding protein actin regulator	-	-	-	-	-	-	-	-	-	-	-	-	Ysc84
SHD2_k127_7234004_27	402881.Plav_1739	1.099e-39	151.0	COG5319@1|root,COG5319@2|Bacteria,1MZN2@1224|Proteobacteria,2UBTA@28211|Alphaproteobacteria,1JPAQ@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1178)	MA20_39715	-	-	-	-	-	-	-	-	-	-	-	DUF1178
SHD2_k127_7234004_15	1333998.M2A_1895	2.228e-104	346.0	COG0388@1|root,COG0388@2|Bacteria,1MUUB@1224|Proteobacteria,2TRGZ@28211|Alphaproteobacteria,4BQ0S@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Carbon-nitrogen hydrolase	MA20_39720	-	-	ko:K11206	-	-	-	-	ko00000,ko01000	-	-	-	CN_hydrolase
SHD2_k127_7234004_31	1333998.M2A_1896	5.428e-31	123.0	COG0695@1|root,COG0695@2|Bacteria,1N72P@1224|Proteobacteria,2UFM1@28211|Alphaproteobacteria,4BQSB@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	O	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins	grxC	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0015035,GO:0015036,GO:0016491,GO:0016667,GO:0033218,GO:0042277,GO:0043167,GO:0043168,GO:0043295,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0055114,GO:0072341,GO:1900750,GO:1901681	-	ko:K03676	-	-	-	-	ko00000,ko03110	-	-	-	Glutaredoxin
SHD2_k127_7234004_20	1089552.KI911559_gene575	5.717e-72	253.0	COG1040@1|root,COG1040@2|Bacteria,1RHAV@1224|Proteobacteria,2TV7G@28211|Alphaproteobacteria,2JSB6@204441|Rhodospirillales	204441|Rhodospirillales	S	Phosphoribosyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
SHD2_k127_7234004_18	1282876.BAOK01000002_gene806	1.221e-83	286.0	COG0500@1|root,COG2226@2|Bacteria,1PA5F@1224|Proteobacteria,2TRFS@28211|Alphaproteobacteria,4BQ39@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	Q	Methyltransferase domain	bioC	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23
SHD2_k127_7234004_41	744980.TRICHSKD4_1779	0.0006797	48.0	COG3847@1|root,COG3847@2|Bacteria,1NGVU@1224|Proteobacteria	1224|Proteobacteria	U	Flp Fap pilin component	-	-	-	ko:K02651	ko04112,map04112	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	Flp_Fap
SHD2_k127_7234004_22	460265.Mnod_1712	4.72e-62	216.0	COG0494@1|root,COG0494@2|Bacteria,1RCZM@1224|Proteobacteria,2U7A4@28211|Alphaproteobacteria,1JUXR@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	PFAM NUDIX hydrolase	mutT	GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Acetyltransf_3,NUDIX,NUDIX_4
SHD2_k127_7234004_29	1408418.JNJH01000003_gene2252	2.51e-36	147.0	COG1670@1|root,COG1670@2|Bacteria,1RIR5@1224|Proteobacteria,2UBMM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
SHD2_k127_7234004_8	231434.JQJH01000005_gene2147	2.391e-155	503.0	COG1364@1|root,COG1364@2|Bacteria,1MU0T@1224|Proteobacteria,2TS98@28211|Alphaproteobacteria,3N9RK@45404|Beijerinckiaceae	28211|Alphaproteobacteria	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	argJ	GO:0003674,GO:0003824,GO:0004042,GO:0004358,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006592,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.1,2.3.1.35	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgJ
SHD2_k127_7234004_0	1282876.BAOK01000002_gene800	0.0	1244.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,2TTBF@28211|Alphaproteobacteria,4BP6T@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	GO:0000166,GO:0002790,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015627,GO:0015628,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032940,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:0098776,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
SHD2_k127_7234004_10	1282876.BAOK01000002_gene795	9.923e-145	469.0	COG0596@1|root,COG0596@2|Bacteria,1MWVN@1224|Proteobacteria,2TQVB@28211|Alphaproteobacteria,4BPWP@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Epoxide hydrolase N terminus	-	-	3.3.2.9	ko:K01253	ko00980,ko04976,ko05204,map00980,map04976,map05204	-	R07013,R07014,R07027,R07071,R07072,R07082,R09410,R09417,R09443	RC01447,RC01728,RC01764,RC02528	ko00000,ko00001,ko01000,ko01002	-	-	-	EHN
SHD2_k127_7234004_12	1079460.ATTQ01000020_gene4364	7.712e-131	426.0	COG0825@1|root,COG0825@2|Bacteria,1MURN@1224|Proteobacteria,2TR6V@28211|Alphaproteobacteria,4B9UG@82115|Rhizobiaceae	28211|Alphaproteobacteria	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA	accA	-	2.1.3.15,6.4.1.2	ko:K01962	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	ACCA
SHD2_k127_7234004_39	1280949.HAD_14657	1.078e-11	72.0	2DPPG@1|root,332W3@2|Bacteria,1N97A@1224|Proteobacteria,2UBCD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_7234004_28	1282876.BAOK01000002_gene274	8.784e-38	154.0	COG2128@1|root,COG2128@2|Bacteria,1N1YR@1224|Proteobacteria,2UENK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_7234004_19	402881.Plav_1721	5.185e-83	287.0	COG1595@1|root,COG1595@2|Bacteria,1MXVA@1224|Proteobacteria,2TV85@28211|Alphaproteobacteria,1JQ3A@119043|Rhodobiaceae	28211|Alphaproteobacteria	K	Sigma-70, region 4	MA20_06780	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
SHD2_k127_7234004_13	1279038.KB907346_gene3289	1.6e-124	408.0	COG2301@1|root,COG2301@2|Bacteria,1MW0A@1224|Proteobacteria,2TU4H@28211|Alphaproteobacteria,2JRHB@204441|Rhodospirillales	204441|Rhodospirillales	G	Belongs to the HpcH HpaI aldolase family	-	-	4.1.3.24,4.1.3.25	ko:K08691	ko00630,ko00660,ko00680,ko00720,ko01120,ko01200,map00630,map00660,map00680,map00720,map01120,map01200	M00346,M00373,M00376	R00237,R00473,R00934	RC00307,RC00308,RC00311,RC00407,RC00502,RC01205	ko00000,ko00001,ko00002,ko01000	-	-	-	HpcH_HpaI
SHD2_k127_7234004_16	1161401.ASJA01000004_gene2197	2.891e-98	331.0	COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,2TRAA@28211|Alphaproteobacteria,43WCW@69657|Hyphomonadaceae	28211|Alphaproteobacteria	D	Belongs to the 'phage' integrase family. XerC subfamily	xerD	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
SHD2_k127_7234004_35	1282876.BAOK01000002_gene790	5.167e-21	108.0	2BWFC@1|root,33R2I@2|Bacteria,1Q71H@1224|Proteobacteria,2VD5F@28211|Alphaproteobacteria,4BSXN@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_7234004_24	1247963.JPHU01000008_gene2804	3.719e-57	203.0	COG0703@1|root,COG0703@2|Bacteria,1MUFJ@1224|Proteobacteria,2U76C@28211|Alphaproteobacteria	28211|Alphaproteobacteria	F	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	aroK	GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	SKI
SHD2_k127_7234004_11	1282876.BAOK01000002_gene787	8.852e-132	432.0	COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,2TRDA@28211|Alphaproteobacteria,4BPMA@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	2.7.1.71,4.2.3.4	ko:K01735,ko:K13829	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412,R03083	RC00002,RC00078,RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase,SKI
SHD2_k127_7234004_9	1333998.M2A_1917	4.578e-148	481.0	COG4536@1|root,COG4536@2|Bacteria,1NZ99@1224|Proteobacteria,2TVZH@28211|Alphaproteobacteria,4BPQF@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	P	Transporter associated domain	corB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
SHD2_k127_7234004_34	1205680.CAKO01000002_gene2368	5.354e-25	106.0	COG0271@1|root,COG0271@2|Bacteria,1MZG5@1224|Proteobacteria,2UF6U@28211|Alphaproteobacteria,2JTXH@204441|Rhodospirillales	204441|Rhodospirillales	T	Belongs to the BolA IbaG family	bolA	-	-	ko:K05527,ko:K22066	-	-	-	-	ko00000,ko03000,ko03029	-	-	-	BolA
SHD2_k127_7234004_26	1122132.AQYH01000007_gene2219	1.342e-44	168.0	COG0484@1|root,COG0484@2|Bacteria,1QU4R@1224|Proteobacteria,2TVZG@28211|Alphaproteobacteria,4B7ES@82115|Rhizobiaceae	28211|Alphaproteobacteria	O	molecular chaperone	dnaJ2	-	-	-	-	-	-	-	-	-	-	-	DnaJ
SHD2_k127_7234004_7	1282876.BAOK01000002_gene783	3.133e-177	559.0	COG0714@1|root,COG0714@2|Bacteria,1MXIW@1224|Proteobacteria,2TS1Z@28211|Alphaproteobacteria,4BPSW@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	PFAM AAA domain (dynein-related subfamily)	cobS	-	6.6.1.2	ko:K09882	ko00860,ko01100,map00860,map01100	-	R05227	RC02000	ko00000,ko00001,ko01000	-	-	-	AAA_5,CbbQ_C,CobS_N
SHD2_k127_7234004_4	402881.Plav_1712	9.155e-239	754.0	COG4547@1|root,COG4547@2|Bacteria,1MX11@1224|Proteobacteria,2TS4N@28211|Alphaproteobacteria,1JNBB@119043|Rhodobiaceae	28211|Alphaproteobacteria	H	Cobalamin biosynthesis protein CobT VWA domain	cobT	-	6.6.1.2	ko:K09883	ko00860,ko01100,map00860,map01100	-	R05227	RC02000	ko00000,ko00001,ko01000	-	-	-	CobT,CobT_C
SHD2_k127_7234004_38	402881.Plav_1707	4.357e-17	91.0	COG1738@1|root,COG1738@2|Bacteria,1NN3F@1224|Proteobacteria,2UMWJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage	-	-	-	ko:K09125	-	-	-	-	ko00000	-	-	-	Vut_1
SHD2_k127_7234004_32	1037409.BJ6T_01770	2.395e-28	118.0	COG0227@1|root,COG0227@2|Bacteria,1MZ57@1224|Proteobacteria,2UBQU@28211|Alphaproteobacteria,3JZCT@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	J	Belongs to the bacterial ribosomal protein bL28 family	rpmB	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
SHD2_k127_7234004_14	402881.Plav_1705	1.322e-118	389.0	COG1703@1|root,COG1703@2|Bacteria,1MVI0@1224|Proteobacteria,2TS96@28211|Alphaproteobacteria,1JN63@119043|Rhodobiaceae	28211|Alphaproteobacteria	E	ArgK protein	argK	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK
SHD2_k127_7234004_37	1282876.BAOK01000002_gene775	6.917e-20	101.0	COG3064@1|root,COG3064@2|Bacteria,1NAWA@1224|Proteobacteria,2TSQY@28211|Alphaproteobacteria,4BSZI@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	M	Protein of unknown function (DUF3108)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3108
SHD2_k127_7234004_1	1333998.M2A_1937	0.0	1056.0	COG1884@1|root,COG1884@2|Bacteria,1MUXX@1224|Proteobacteria,2TQYC@28211|Alphaproteobacteria,4BR6X@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	I	Methylmalonyl-CoA mutase	bhbA	-	5.4.99.2	ko:K01847	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,MM_CoA_mutase
SHD2_k127_7234004_2	402881.Plav_1698	7.684e-270	856.0	COG4581@1|root,COG4581@2|Bacteria,1MVD6@1224|Proteobacteria,2TR7N@28211|Alphaproteobacteria,1JNJP@119043|Rhodobiaceae	28211|Alphaproteobacteria	L	helicase superfamily c-terminal domain	mgpS	-	3.6.4.13	ko:K17675	-	-	-	-	ko00000,ko01000,ko03029	-	-	-	Helicase_C
SHD2_k127_7234004_33	1317118.ATO8_11199	4.454e-26	109.0	COG1188@1|root,COG1188@2|Bacteria,1MZR6@1224|Proteobacteria,2UBS3@28211|Alphaproteobacteria,4KMVD@93682|Roseivivax	28211|Alphaproteobacteria	J	S4 RNA-binding domain	hslR	-	-	ko:K04762	-	-	-	-	ko00000,ko03110	-	-	-	S4
SHD2_k127_7234004_23	266779.Meso_3378	3.755e-61	212.0	COG1146@1|root,COG1146@2|Bacteria,1RH5I@1224|Proteobacteria,2U98K@28211|Alphaproteobacteria,43K14@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions	fdxA	-	-	ko:K05524	-	-	-	-	ko00000	-	-	-	DUF3470,Fer4,Fer4_4
SHD2_k127_7234004_21	1417296.U879_14415	1.752e-68	237.0	COG1329@1|root,COG1329@2|Bacteria,1MWI2@1224|Proteobacteria,2TTVP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	transcriptional regulator	carD	-	-	ko:K07736	-	-	-	-	ko00000,ko03000	-	-	-	CarD_CdnL_TRCF
SHD2_k127_7234004_36	1082931.KKY_2948	2.101e-20	93.0	COG1525@1|root,COG1525@2|Bacteria,1R3VA@1224|Proteobacteria,2U0NK@28211|Alphaproteobacteria,3N73J@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Staphylococcal nuclease homologue	-	-	-	-	-	-	-	-	-	-	-	-	SNase
SHD2_k127_730769_1	1088721.NSU_3399	1.042e-22	111.0	COG5285@1|root,COG5285@2|Bacteria,1NWIU@1224|Proteobacteria,2USKY@28211|Alphaproteobacteria,2KAGB@204457|Sphingomonadales	204457|Sphingomonadales	Q	Phytanoyl-CoA dioxygenase (PhyH)	-	-	-	-	-	-	-	-	-	-	-	-	PhyH
SHD2_k127_730769_0	471852.Tcur_0775	9.258e-142	464.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4EHI3@85012|Streptosporangiales	201174|Actinobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
SHD2_k127_7384178_1	1040989.AWZU01000114_gene5056	3.866e-114	369.0	2BQCT@1|root,32J80@2|Bacteria,1MVNM@1224|Proteobacteria,2U1V2@28211|Alphaproteobacteria,3JU0F@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_7384178_0	335659.S23_19610	2.313e-287	885.0	COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,2TTXG@28211|Alphaproteobacteria,3JVJZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
SHD2_k127_7437384_28	1041930.Mtc_1674	8.733e-12	70.0	COG0346@1|root,arCOG02708@2157|Archaea	2157|Archaea	E	COG0346 Lactoylglutathione lyase and related lyases	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase,Glyoxalase_4
SHD2_k127_7437384_30	1236902.ANAS01000037_gene5438	1.488e-09	67.0	COG1266@1|root,COG1266@2|Bacteria	2|Bacteria	V	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
SHD2_k127_7437384_9	1380347.JNII01000005_gene3108	5.797e-70	246.0	COG1917@1|root,COG2114@1|root,COG1917@2|Bacteria,COG2114@2|Bacteria,2IASU@201174|Actinobacteria	201174|Actinobacteria	IT	Pfam Adenylate and Guanylate cyclase catalytic domain	lipJ	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Guanylate_cyc
SHD2_k127_7437384_7	1380390.JIAT01000010_gene3916	1.486e-87	296.0	COG0394@1|root,COG0640@1|root,COG0394@2|Bacteria,COG0640@2|Bacteria,2HEP3@201174|Actinobacteria,4CTHA@84995|Rubrobacteria	84995|Rubrobacteria	T	low molecular weight phosphotyrosine protein phosphatase	-	-	1.20.4.1	ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
SHD2_k127_7437384_13	1449044.JMLE01000003_gene2912	2.14e-53	192.0	COG0346@1|root,COG0346@2|Bacteria,2IKNQ@201174|Actinobacteria	201174|Actinobacteria	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
SHD2_k127_7437384_36	864069.MicloDRAFT_00018160	0.0004568	49.0	COG0346@1|root,COG0346@2|Bacteria,1N1P8@1224|Proteobacteria,2UEQZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	ko:K08234	-	-	-	-	ko00000	-	-	-	Glyoxalase
SHD2_k127_7437384_19	234267.Acid_3202	2.167e-36	151.0	COG0596@1|root,COG0596@2|Bacteria,3Y89S@57723|Acidobacteria	57723|Acidobacteria	S	PFAM alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
SHD2_k127_7437384_18	234267.Acid_3202	8.459e-41	165.0	COG0596@1|root,COG0596@2|Bacteria,3Y89S@57723|Acidobacteria	57723|Acidobacteria	S	PFAM alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
SHD2_k127_7437384_33	335659.S23_13660	1.436e-05	49.0	2AE5D@1|root,313YU@2|Bacteria,1N8PP@1224|Proteobacteria,2UG2Q@28211|Alphaproteobacteria,3K151@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_7437384_21	1131814.JAFO01000001_gene462	1.358e-32	135.0	2DXAI@1|root,3444M@2|Bacteria,1P0TN@1224|Proteobacteria,2UVMP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_3
SHD2_k127_7437384_20	1333998.M2A_2696	5.669e-34	138.0	COG5388@1|root,COG5388@2|Bacteria,1NB5B@1224|Proteobacteria	1224|Proteobacteria	S	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	PAS_5
SHD2_k127_7437384_22	111781.Lepto7376_2074	2.434e-32	130.0	COG0346@1|root,COG0346@2|Bacteria,1GESA@1117|Cyanobacteria	1117|Cyanobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
SHD2_k127_7437384_31	864069.MicloDRAFT_00013920	4.959e-09	64.0	2EM9G@1|root,33EYK@2|Bacteria,1P8EM@1224|Proteobacteria,2UYGB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_7437384_16	331869.BAL199_18636	3.918e-44	171.0	COG3000@1|root,COG3000@2|Bacteria,1MW5G@1224|Proteobacteria,2TU63@28211|Alphaproteobacteria,4BSNZ@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	I	Fatty acid hydroxylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
SHD2_k127_7437384_25	745310.G432_13305	9.293e-22	102.0	COG3791@1|root,COG3791@2|Bacteria,1N7AZ@1224|Proteobacteria,2UFKY@28211|Alphaproteobacteria,2K6EG@204457|Sphingomonadales	204457|Sphingomonadales	S	Glutathione-dependent formaldehyde-activating	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_7437384_11	196367.JNFG01000199_gene3597	2.315e-55	199.0	COG2259@1|root,COG2259@2|Bacteria,1PXME@1224|Proteobacteria,2WD0S@28216|Betaproteobacteria,1K8YP@119060|Burkholderiaceae	28216|Betaproteobacteria	S	DoxX	-	-	-	-	-	-	-	-	-	-	-	-	DoxX
SHD2_k127_7437384_17	1040987.AZUY01000031_gene4623	6.138e-42	160.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
SHD2_k127_7437384_34	859657.RPSI07_1464	8.467e-05	50.0	COG0848@1|root,COG0848@2|Bacteria,1MZ6M@1224|Proteobacteria,2VSVW@28216|Betaproteobacteria,1K70R@119060|Burkholderiaceae	28216|Betaproteobacteria	U	PFAM Biopolymer transport protein ExbD TolR	exbD1	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
SHD2_k127_7437384_29	1121438.JNJA01000006_gene193	2.477e-10	63.0	COG3847@1|root,COG3847@2|Bacteria,1NGVU@1224|Proteobacteria,42X6U@68525|delta/epsilon subdivisions,2WSP7@28221|Deltaproteobacteria,2MDVB@213115|Desulfovibrionales	28221|Deltaproteobacteria	U	PFAM Flp Fap pilin component	-	-	-	ko:K02651	ko04112,map04112	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	Flp_Fap
SHD2_k127_7437384_0	1122604.JONR01000008_gene2157	8.939e-219	691.0	COG2939@1|root,COG2939@2|Bacteria,1MW05@1224|Proteobacteria,1RQJY@1236|Gammaproteobacteria,1X5C0@135614|Xanthomonadales	135614|Xanthomonadales	E	Serine carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S10
SHD2_k127_7437384_6	1121123.AUAO01000003_gene2294	2.417e-100	335.0	COG0730@1|root,COG0730@2|Bacteria,1R6MR@1224|Proteobacteria,2URRK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Sulfite exporter TauE/SafE	-	-	-	-	-	-	-	-	-	-	-	-	TauE
SHD2_k127_7437384_27	402881.Plav_2591	5.092e-12	72.0	COG5388@1|root,COG5388@2|Bacteria,1NZZK@1224|Proteobacteria,2UTZS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	PAS_5
SHD2_k127_7437384_1	1382303.JPOM01000001_gene1731	8.695e-184	584.0	COG2124@1|root,COG2124@2|Bacteria,1MV8Q@1224|Proteobacteria,2TRWW@28211|Alphaproteobacteria,2KHW8@204458|Caulobacterales	204458|Caulobacterales	C	cytochrome P450	-	-	-	-	-	-	-	-	-	-	-	-	p450
SHD2_k127_7437384_32	1279017.AQYJ01000026_gene79	7.858e-06	57.0	COG1266@1|root,COG1266@2|Bacteria,1NIGX@1224|Proteobacteria,1S3TI@1236|Gammaproteobacteria,46BQU@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
SHD2_k127_7437384_14	926560.KE387023_gene2407	1.272e-47	175.0	COG1832@1|root,COG1832@2|Bacteria	2|Bacteria	S	CoA binding domain	-	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
SHD2_k127_7437384_24	517418.Ctha_0741	4.22e-25	113.0	COG2010@1|root,COG2010@2|Bacteria,1FEAI@1090|Chlorobi	1090|Chlorobi	C	Haem-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Haem_bd
SHD2_k127_7437384_23	1238182.C882_4341	1.549e-31	127.0	2CKXE@1|root,32SD6@2|Bacteria,1N1MJ@1224|Proteobacteria,2UBTY@28211|Alphaproteobacteria,2JTP8@204441|Rhodospirillales	204441|Rhodospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_7437384_3	402881.Plav_0935	5.811e-139	452.0	COG1804@1|root,COG1804@2|Bacteria,1PJ8T@1224|Proteobacteria,2V8SH@28211|Alphaproteobacteria,1JQ3K@119043|Rhodobiaceae	28211|Alphaproteobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
SHD2_k127_7437384_12	1282876.BAOK01000001_gene2567	8.568e-55	210.0	28K9G@1|root,2Z9X1@2|Bacteria,1NEMY@1224|Proteobacteria,2U0J7@28211|Alphaproteobacteria,4BSY8@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	-	-	MA20_15515	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_7437384_4	1333998.M2A_1655	1.226e-118	396.0	COG0642@1|root,COG0642@2|Bacteria,1MX6R@1224|Proteobacteria,2TS9N@28211|Alphaproteobacteria,4BQ1X@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	T	His Kinase A (phosphoacceptor) domain	feuQ	-	-	-	-	-	-	-	-	-	-	-	2CSK_N,HATPase_c
SHD2_k127_7437384_5	1282876.BAOK01000001_gene2572	3.158e-111	363.0	COG0745@1|root,COG0745@2|Bacteria,1N0YI@1224|Proteobacteria,2TSV8@28211|Alphaproteobacteria,4BRES@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	T	Transcriptional regulatory protein, C terminal	feuP	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
SHD2_k127_7437384_37	1280954.HPO_08304	0.0009183	48.0	COG3212@1|root,COG3212@2|Bacteria,1NHDB@1224|Proteobacteria,2V997@28211|Alphaproteobacteria,440CH@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	PepSY_2
SHD2_k127_7437384_8	1245469.S58_21200	9.419e-74	255.0	COG0778@1|root,COG0778@2|Bacteria,1PG8V@1224|Proteobacteria,2U59W@28211|Alphaproteobacteria,3JVH7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
SHD2_k127_7437384_2	269482.Bcep1808_1656	1.495e-179	574.0	COG2059@1|root,COG2059@2|Bacteria,1MUBW@1224|Proteobacteria,2VHPW@28216|Betaproteobacteria,1K55C@119060|Burkholderiaceae	28216|Betaproteobacteria	P	TIGRFAM chromate transporter, chromate ion transporter (CHR) family	chrA	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
SHD2_k127_7437384_10	883078.HMPREF9695_00590	2.86e-56	203.0	COG2135@1|root,COG2135@2|Bacteria,1RER4@1224|Proteobacteria,2U0W2@28211|Alphaproteobacteria,3JV7R@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Belongs to the SOS response-associated peptidase family	-	-	-	-	-	-	-	-	-	-	-	-	SRAP
SHD2_k127_7437384_15	631454.N177_0420	4.576e-47	180.0	COG4655@1|root,COG4655@2|Bacteria,1RGJG@1224|Proteobacteria,2U32U@28211|Alphaproteobacteria	28211|Alphaproteobacteria	U	Putative Flp pilus-assembly TadE/G-like	-	-	-	-	-	-	-	-	-	-	-	-	Tad
SHD2_k127_7468224_0	1298867.AUES01000007_gene5087	1.415e-182	573.0	COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,2TQP1@28211|Alphaproteobacteria,3JR26@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Belongs to the heme-copper respiratory oxidase family	cyoB	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009486,GO:0009987,GO:0015002,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0016491,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0034220,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600	1.10.3.10	ko:K02298	ko00190,ko01100,map00190,map01100	M00417	R11335	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.5	-	-	COX1
SHD2_k127_7468224_2	1380355.JNIJ01000010_gene1487	4.765e-115	379.0	COG1622@1|root,COG1622@2|Bacteria,1MWHZ@1224|Proteobacteria,2U0IR@28211|Alphaproteobacteria,3JS69@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	ubiquinol oxidase subunit	cyoA	-	1.10.3.10	ko:K02297	ko00190,ko01100,map00190,map01100	M00417	R11335	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.5	-	-	COX2,COX_ARM
SHD2_k127_7468224_4	1123393.KB891326_gene30	1.689e-49	184.0	COG0778@1|root,COG0778@2|Bacteria,1Q0ZY@1224|Proteobacteria,2WAFT@28216|Betaproteobacteria,1KSUE@119069|Hydrogenophilales	119069|Hydrogenophilales	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
SHD2_k127_7468224_5	936455.KI421499_gene1715	3.25e-37	150.0	COG3673@1|root,COG3673@2|Bacteria,1NFRW@1224|Proteobacteria,2TQTY@28211|Alphaproteobacteria,3JT8P@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Uncharacterized alpha/beta hydrolase domain (DUF2235)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2235
SHD2_k127_7468224_1	1231391.AMZF01000003_gene3182	4.109e-165	529.0	COG2159@1|root,COG2159@2|Bacteria,1MXI7@1224|Proteobacteria,2WG6Y@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Amidohydrolase	-	-	4.1.1.45	ko:K03392	ko00380,ko01100,map00380,map01100	M00038	R04323	RC00779	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_2
SHD2_k127_7468224_6	323097.Nham_2529	1.534e-21	97.0	COG0582@1|root,COG0582@2|Bacteria,1R7FT@1224|Proteobacteria,2U4R9@28211|Alphaproteobacteria,3JS4F@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Arm-DNA-bind_3,Phage_int_SAM_1,Phage_integrase
SHD2_k127_7468224_3	224911.27353034	1.844e-98	329.0	COG0457@1|root,COG0741@1|root,COG0457@2|Bacteria,COG0741@2|Bacteria,1MV3F@1224|Proteobacteria,2TRDB@28211|Alphaproteobacteria,3JUG1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Transglycosylase SLT domain	slt	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	SLT
SHD2_k127_7558494_37	1205680.CAKO01000038_gene1965	2.52e-34	139.0	COG2930@1|root,COG2930@2|Bacteria,1RHV6@1224|Proteobacteria,2U9N6@28211|Alphaproteobacteria,2JSQS@204441|Rhodospirillales	204441|Rhodospirillales	S	Las17-binding protein actin regulator	-	-	-	-	-	-	-	-	-	-	-	-	Ysc84
SHD2_k127_7558494_28	1121015.N789_05965	1.379e-53	196.0	COG2928@1|root,COG2928@2|Bacteria,1MWT5@1224|Proteobacteria,1S5DB@1236|Gammaproteobacteria,1X4XD@135614|Xanthomonadales	135614|Xanthomonadales	S	Protein of unknown function (DUF502)	YH67_14670	-	-	-	-	-	-	-	-	-	-	-	DUF502
SHD2_k127_7558494_3	450851.PHZ_c1207	1.014e-231	730.0	COG0143@1|root,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,2TQKA@28211|Alphaproteobacteria,2KFCM@204458|Caulobacterales	204458|Caulobacterales	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g
SHD2_k127_7558494_43	189753.AXAS01000009_gene6401	3.423e-24	109.0	COG0454@1|root,COG0456@2|Bacteria,1QU9D@1224|Proteobacteria,2TWZF@28211|Alphaproteobacteria,3JYDP@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
SHD2_k127_7558494_20	472175.EL18_01500	1.021e-92	310.0	COG2935@1|root,COG2935@2|Bacteria,1MW62@1224|Proteobacteria,2TQY8@28211|Alphaproteobacteria,43I4T@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	O	May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate	ate	GO:0003674,GO:0003824,GO:0004057,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006508,GO:0006511,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016598,GO:0016740,GO:0016746,GO:0016755,GO:0019538,GO:0019941,GO:0030163,GO:0036211,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575	2.3.2.29	ko:K21420	-	-	R11547,R11548	RC00064	ko00000,ko01000	-	-	-	ATE_C,ATE_N
SHD2_k127_7558494_19	1161401.ASJA01000009_gene1806	2.712e-95	321.0	COG1360@1|root,COG1360@2|Bacteria,1MW1Y@1224|Proteobacteria,2TTW2@28211|Alphaproteobacteria,43W4M@69657|Hyphomonadaceae	28211|Alphaproteobacteria	N	chemotaxis MotB protein	motB	-	-	ko:K02557	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotB_plug,OmpA
SHD2_k127_7558494_29	402881.Plav_2888	3.322e-50	183.0	COG1853@1|root,COG1853@2|Bacteria,1RGYM@1224|Proteobacteria,2UCHI@28211|Alphaproteobacteria,1JP71@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Flavin reductase like domain	ntaB	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
SHD2_k127_7558494_26	1121022.ABENE_21090	8.558e-67	249.0	COG3746@1|root,COG3746@2|Bacteria,1RA39@1224|Proteobacteria,2U9KD@28211|Alphaproteobacteria,2KFTY@204458|Caulobacterales	204458|Caulobacterales	P	PFAM Phosphate-selective porin O and P	-	-	-	ko:K07221	-	-	-	-	ko00000,ko02000	1.B.5.1	-	-	Porin_O_P
SHD2_k127_7558494_13	1380391.JIAS01000013_gene3644	8.005e-131	428.0	COG0226@1|root,COG0226@2|Bacteria,1MUAZ@1224|Proteobacteria,2TTJA@28211|Alphaproteobacteria,2JV0W@204441|Rhodospirillales	204441|Rhodospirillales	P	Part of the ABC transporter complex PstSACB involved in phosphate import	-	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
SHD2_k127_7558494_41	1207063.P24_17077	1.242e-26	113.0	COG2005@1|root,COG2005@2|Bacteria,1P9SX@1224|Proteobacteria,2UC9Q@28211|Alphaproteobacteria,2JTWN@204441|Rhodospirillales	204441|Rhodospirillales	H	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	ko:K02019	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,TOBE
SHD2_k127_7558494_36	1121106.JQKB01000004_gene2417	3.613e-36	142.0	COG1846@1|root,COG1846@2|Bacteria,1MZY5@1224|Proteobacteria,2U9EE@28211|Alphaproteobacteria,2JTET@204441|Rhodospirillales	204441|Rhodospirillales	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
SHD2_k127_7558494_18	1211115.ALIQ01000200_gene482	2.364e-98	334.0	COG1566@1|root,COG1566@2|Bacteria,1MU7I@1224|Proteobacteria,2TS39@28211|Alphaproteobacteria,3NAUP@45404|Beijerinckiaceae	28211|Alphaproteobacteria	V	HlyD family secretion protein	-	-	-	ko:K03543	-	M00701	-	-	ko00000,ko00002,ko02000	8.A.1.1	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
SHD2_k127_7558494_6	1211115.ALIQ01000200_gene483	1.68e-198	632.0	COG0477@1|root,COG2814@2|Bacteria,1MU1I@1224|Proteobacteria,2TVXT@28211|Alphaproteobacteria,3ND1F@45404|Beijerinckiaceae	28211|Alphaproteobacteria	P	Sugar (and other) transporter	-	-	-	ko:K03446	-	M00701	-	-	ko00000,ko00002,ko02000	2.A.1.3	-	-	MFS_1,Sugar_tr
SHD2_k127_7558494_14	231434.JQJH01000016_gene1382	1.459e-122	411.0	COG2084@1|root,COG2084@2|Bacteria,1MUGU@1224|Proteobacteria,2TT50@28211|Alphaproteobacteria,3NAG4@45404|Beijerinckiaceae	28211|Alphaproteobacteria	I	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	MA20_25935	-	1.1.1.31,1.1.1.60	ko:K00020,ko:K00042	ko00280,ko00630,ko01100,map00280,map00630,map01100	-	R01745,R01747,R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
SHD2_k127_7558494_39	102129.Lepto7375DRAFT_1543	1.981e-31	130.0	COG1309@1|root,COG1309@2|Bacteria,1G61G@1117|Cyanobacteria,1HFKG@1150|Oscillatoriales	1117|Cyanobacteria	K	WHG domain	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N,WHG
SHD2_k127_7558494_10	402881.Plav_2897	1.812e-156	501.0	COG0113@1|root,COG0113@2|Bacteria,1MWMW@1224|Proteobacteria,2TS3F@28211|Alphaproteobacteria,1JNJS@119043|Rhodobiaceae	28211|Alphaproteobacteria	H	Delta-aminolevulinic acid dehydratase	hemB	GO:0003674,GO:0003824,GO:0004655,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
SHD2_k127_7558494_8	1282876.BAOK01000001_gene1893	3.309e-182	576.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TQKE@28211|Alphaproteobacteria,4BPZR@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	MA20_27425	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
SHD2_k127_7558494_27	1282876.BAOK01000001_gene1897	1.214e-59	211.0	COG1846@1|root,COG1846@2|Bacteria,1RA1V@1224|Proteobacteria,2U5W6@28211|Alphaproteobacteria,4BQJV@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	K	helix_turn_helix multiple antibiotic resistance protein	mucS	-	-	-	-	-	-	-	-	-	-	-	HTH_27
SHD2_k127_7558494_34	1144343.PMI41_00922	5.113e-39	154.0	COG4291@1|root,COG4291@2|Bacteria,1RKVD@1224|Proteobacteria,2VGBS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1345)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1345
SHD2_k127_7558494_7	402881.Plav_2905	1.014e-182	582.0	COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,2TQXI@28211|Alphaproteobacteria,1JN7T@119043|Rhodobiaceae	28211|Alphaproteobacteria	H	Cys/Met metabolism PLP-dependent enzyme	hemA	-	2.3.1.37	ko:K00643	ko00260,ko00860,ko01100,ko01110,map00260,map00860,map01100,map01110	-	R00830	RC00004,RC02815	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
SHD2_k127_7558494_48	991905.SL003B_1915	1.289e-06	53.0	2DPUN@1|root,333FG@2|Bacteria,1N8NF@1224|Proteobacteria,2UIAJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_7558494_30	414684.RC1_1344	7.842e-49	178.0	COG4957@1|root,COG4957@2|Bacteria,1RGUW@1224|Proteobacteria,2U99M@28211|Alphaproteobacteria,2JST9@204441|Rhodospirillales	204441|Rhodospirillales	K	ROS/MUCR transcriptional regulator protein	-	-	-	-	-	-	-	-	-	-	-	-	ROS_MUCR
SHD2_k127_7558494_5	1125973.JNLC01000017_gene3704	3.107e-210	660.0	COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,2TQKT@28211|Alphaproteobacteria,3JTRF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
SHD2_k127_7558494_24	1282876.BAOK01000001_gene1905	5.847e-68	233.0	COG1327@1|root,COG1327@2|Bacteria,1RE7V@1224|Proteobacteria,2U75W@28211|Alphaproteobacteria,4BQ7B@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	-	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
SHD2_k127_7558494_16	331869.BAL199_25529	6.986e-106	354.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1MUWT@1224|Proteobacteria,2TR70@28211|Alphaproteobacteria,4BQ24@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	ribD	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
SHD2_k127_7558494_22	1121033.AUCF01000018_gene5833	5.405e-84	282.0	COG0307@1|root,COG0307@2|Bacteria,1MUMB@1224|Proteobacteria,2U3RS@28211|Alphaproteobacteria,2JR8K@204441|Rhodospirillales	204441|Rhodospirillales	H	Riboflavin synthase alpha chain	ribE	-	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	Lum_binding
SHD2_k127_7558494_9	402881.Plav_2912	1.154e-162	520.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1MU8P@1224|Proteobacteria,2TSMA@28211|Alphaproteobacteria,1JNG7@119043|Rhodobiaceae	28211|Alphaproteobacteria	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribB	-	3.5.4.25,4.1.99.12	ko:K02858,ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2
SHD2_k127_7558494_31	935261.JAGL01000009_gene1192	2.114e-48	177.0	COG0054@1|root,COG0054@2|Bacteria,1RD9J@1224|Proteobacteria,2U9IZ@28211|Alphaproteobacteria,43JPB@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
SHD2_k127_7558494_33	394221.Mmar10_1531	2.591e-39	153.0	COG0781@1|root,COG0781@2|Bacteria,1RHFZ@1224|Proteobacteria,2UBQA@28211|Alphaproteobacteria,43XVD@69657|Hyphomonadaceae	28211|Alphaproteobacteria	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
SHD2_k127_7558494_21	1207063.P24_04999	2.676e-86	295.0	COG0611@1|root,COG0611@2|Bacteria,1MU9X@1224|Proteobacteria,2TTI6@28211|Alphaproteobacteria,2JQC6@204441|Rhodospirillales	204441|Rhodospirillales	F	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
SHD2_k127_7558494_47	450851.PHZ_c1665	4.342e-09	63.0	2E4AU@1|root,32Z6H@2|Bacteria,1N7K9@1224|Proteobacteria,2UFGR@28211|Alphaproteobacteria,2KH9M@204458|Caulobacterales	204458|Caulobacterales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_7558494_0	402881.Plav_2916	5e-324	1006.0	COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,2TR9G@28211|Alphaproteobacteria,1JNE9@119043|Rhodobiaceae	28211|Alphaproteobacteria	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
SHD2_k127_7558494_38	1161401.ASJA01000009_gene1763	7.151e-34	136.0	COG2913@1|root,COG2913@2|Bacteria,1RHYM@1224|Proteobacteria,2UBU9@28211|Alphaproteobacteria,43XVP@69657|Hyphomonadaceae	28211|Alphaproteobacteria	J	COG2913 Small protein A (tmRNA-binding)	MA20_36760	-	-	-	-	-	-	-	-	-	-	-	SmpA_OmlA
SHD2_k127_7558494_42	1380394.JADL01000004_gene5756	2.385e-26	115.0	COG5452@1|root,COG5452@2|Bacteria,1N12T@1224|Proteobacteria,2UCES@28211|Alphaproteobacteria,2JTNK@204441|Rhodospirillales	204441|Rhodospirillales	S	Ubiquinol-cytochrome C chaperone	-	-	-	ko:K17662	-	-	-	-	ko00000,ko03029	-	-	-	Ubiq_cyt_C_chap
SHD2_k127_7558494_45	1122214.AQWH01000001_gene684	7.184e-19	96.0	COG1399@1|root,COG1399@2|Bacteria,1N7C2@1224|Proteobacteria,2UC4J@28211|Alphaproteobacteria,2PK2H@255475|Aurantimonadaceae	28211|Alphaproteobacteria	S	Uncharacterized ACR, COG1399	-	-	-	ko:K07040	-	-	-	-	ko00000	-	-	-	DUF177
SHD2_k127_7558494_44	1279038.KB907337_gene453	4.082e-24	104.0	COG0333@1|root,COG0333@2|Bacteria,1PU3Y@1224|Proteobacteria,2UF54@28211|Alphaproteobacteria,2JTZ3@204441|Rhodospirillales	204441|Rhodospirillales	J	Belongs to the bacterial ribosomal protein bL32 family	rpmF	-	-	ko:K02911	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_L32p
SHD2_k127_7558494_15	1144343.PMI41_04432	4.935e-113	374.0	COG0416@1|root,COG0416@2|Bacteria,1MVM3@1224|Proteobacteria,2TR53@28211|Alphaproteobacteria,43IX0@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA	plsX	-	2.3.1.15	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_synthesis
SHD2_k127_7558494_12	1150626.PHAMO_340022	4.812e-139	451.0	COG0332@1|root,COG0332@2|Bacteria,1MU9N@1224|Proteobacteria,2TR60@28211|Alphaproteobacteria,2JQQP@204441|Rhodospirillales	204441|Rhodospirillales	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
SHD2_k127_7558494_35	639283.Snov_1666	1.081e-37	143.0	COG0776@1|root,COG0776@2|Bacteria,1RH5Z@1224|Proteobacteria,2UCDG@28211|Alphaproteobacteria,3EZN0@335928|Xanthobacteraceae	28211|Alphaproteobacteria	K	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control	himA	-	-	ko:K04764	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
SHD2_k127_7558494_32	1333998.M2A_0600	2.143e-39	153.0	COG0789@1|root,COG0789@2|Bacteria,1RGYB@1224|Proteobacteria,2U9A5@28211|Alphaproteobacteria,4BQR6@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	K	MerR HTH family regulatory protein	merR	-	-	-	-	-	-	-	-	-	-	-	MerR_1
SHD2_k127_7558494_25	1082933.MEA186_07689	8.674e-68	238.0	COG2518@1|root,COG2518@2|Bacteria,1NARK@1224|Proteobacteria,2UG84@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_7558494_23	398525.KB900701_gene3352	7.699e-77	260.0	COG3260@1|root,COG3260@2|Bacteria,1QUBE@1224|Proteobacteria,2U279@28211|Alphaproteobacteria,3JTGI@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	NADH ubiquinone oxidoreductase, 20 Kd subunit	hycG	-	-	-	-	-	-	-	-	-	-	-	Oxidored_q6
SHD2_k127_7558494_4	1380350.JIAP01000010_gene5851	5.581e-227	712.0	COG3261@1|root,COG3262@1|root,COG3261@2|Bacteria,COG3262@2|Bacteria,1QUBF@1224|Proteobacteria,2TRE0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	NADH-ubiquinone oxidoreductase chain 49kDa	hycE	-	-	-	-	-	-	-	-	-	-	-	Complex1_30kDa,Complex1_49kDa,NiFeSe_Hases
SHD2_k127_7558494_2	224911.27354621	2.428e-244	764.0	COG0651@1|root,COG0651@2|Bacteria,1MVBA@1224|Proteobacteria,2TSRU@28211|Alphaproteobacteria,3JWX4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	CP	Proton-conducting membrane transporter	hyfF	-	-	ko:K12141	-	-	-	-	ko00000,ko01000	-	-	-	Proton_antipo_M
SHD2_k127_7558494_17	1041146.ATZB01000023_gene2666	6.669e-103	338.0	COG4237@1|root,COG4237@2|Bacteria,1NAT8@1224|Proteobacteria,2TUAC@28211|Alphaproteobacteria,4BA7A@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	COG4237 Hydrogenase 4 membrane component (E)	hyfE	-	-	ko:K12140	-	-	-	-	ko00000,ko01000	-	-	-	-
SHD2_k127_7558494_11	1038858.AXBA01000006_gene910	6.235e-140	454.0	COG0650@1|root,COG0650@2|Bacteria,1MXV5@1224|Proteobacteria,2U0GZ@28211|Alphaproteobacteria,3F17Z@335928|Xanthobacteraceae	28211|Alphaproteobacteria	C	NADH dehydrogenase	hycD	-	-	-	-	-	-	-	-	-	-	-	NADHdh
SHD2_k127_7558494_1	663610.JQKO01000005_gene2406	5.028e-287	895.0	COG0651@1|root,COG0651@2|Bacteria,1MXRW@1224|Proteobacteria,2TZIX@28211|Alphaproteobacteria,3NC92@45404|Beijerinckiaceae	28211|Alphaproteobacteria	CP	Proton-conducting membrane transporter	hyfB	-	-	-	-	-	-	-	-	-	-	-	Proton_antipo_M
SHD2_k127_7558494_40	536019.Mesop_2133	7.829e-28	118.0	COG1396@1|root,COG1396@2|Bacteria,1MZQK@1224|Proteobacteria,2UCAK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,HTH_31
SHD2_k127_7558494_46	1121861.KB899911_gene1292	7.151e-10	59.0	COG1396@1|root,COG1396@2|Bacteria,1MZQK@1224|Proteobacteria,2UCAK@28211|Alphaproteobacteria,2JTTV@204441|Rhodospirillales	204441|Rhodospirillales	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,HTH_31
SHD2_k127_7560602_171	1388763.O165_011055	2.722e-37	148.0	COG3153@1|root,COG3153@2|Bacteria,1QU3M@1224|Proteobacteria,1T1V7@1236|Gammaproteobacteria,1YZNS@136845|Pseudomonas putida group	1236|Gammaproteobacteria	S	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_7
SHD2_k127_7560602_46	1333998.M2A_2344	9.568e-134	439.0	COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,2TUEW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EGP	Major facilitator Superfamily	tetA	-	-	ko:K08151	-	M00668	-	-	ko00000,ko00002,ko01504,ko02000	2.A.1.2.38,2.A.1.2.39,2.A.1.2.4,2.A.1.2.41,2.A.1.2.68,2.A.1.2.75	-	-	MFS_1,Sugar_tr
SHD2_k127_7560602_218	582899.Hden_2620	4.05e-08	56.0	COG5570@1|root,COG5570@2|Bacteria	2|Bacteria	S	small protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF465
SHD2_k127_7560602_112	450851.PHZ_c3291	3.215e-77	264.0	COG0163@1|root,COG0163@2|Bacteria,1RA0P@1224|Proteobacteria,2U5GN@28211|Alphaproteobacteria,2KFC4@204458|Caulobacterales	204458|Caulobacterales	H	Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN	ubiX	-	2.5.1.129	ko:K03186	ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220	M00117	R01238,R02952,R03367,R04985,R04986,R11225	RC00391,RC00814,RC03392	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavoprotein
SHD2_k127_7560602_210	1219049.SP5_005_00640	1.023e-14	79.0	COG5481@1|root,COG5481@2|Bacteria,1NG9U@1224|Proteobacteria,2UFXJ@28211|Alphaproteobacteria,2K6XC@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function (DUF465)	-	-	-	-	-	-	-	-	-	-	-	-	DUF465
SHD2_k127_7560602_135	402881.Plav_2079	2.502e-60	217.0	COG2199@1|root,COG2199@2|Bacteria,1Q7FU@1224|Proteobacteria,2TRE7@28211|Alphaproteobacteria,1JQDV@119043|Rhodobiaceae	28211|Alphaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
SHD2_k127_7560602_127	1123240.ATVO01000006_gene1456	1.011e-66	231.0	COG0041@1|root,COG0041@2|Bacteria,1RCWJ@1224|Proteobacteria,2U58D@28211|Alphaproteobacteria,2K3Z8@204457|Sphingomonadales	204457|Sphingomonadales	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
SHD2_k127_7560602_60	402881.Plav_2071	4.467e-120	398.0	COG0026@1|root,COG0026@2|Bacteria,1MU70@1224|Proteobacteria,2TRSV@28211|Alphaproteobacteria,1JNF9@119043|Rhodobiaceae	28211|Alphaproteobacteria	F	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)	purK	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	6.3.4.18	ko:K01589	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07404	RC01927	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp
SHD2_k127_7560602_24	1038859.AXAU01000001_gene3142	7.993e-180	569.0	COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,2TSRD@28211|Alphaproteobacteria,3JV4V@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
SHD2_k127_7560602_151	1380394.JADL01000003_gene4972	5.448e-46	174.0	COG5590@1|root,COG5590@2|Bacteria,1MW25@1224|Proteobacteria,2U9ST@28211|Alphaproteobacteria,2JSMS@204441|Rhodospirillales	204441|Rhodospirillales	S	COQ9	-	-	-	ko:K18587	-	-	-	-	ko00000	-	-	-	COQ9
SHD2_k127_7560602_110	1333998.M2A_2147	2.018e-78	265.0	COG0242@1|root,COG0242@2|Bacteria,1R9XK@1224|Proteobacteria,2U7NP@28211|Alphaproteobacteria,4BSH6@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	-	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
SHD2_k127_7560602_187	187303.BN69_0524	7.977e-28	115.0	COG0828@1|root,COG0828@2|Bacteria,1MZA1@1224|Proteobacteria,2UC58@28211|Alphaproteobacteria,36YZY@31993|Methylocystaceae	28211|Alphaproteobacteria	J	Ribosomal protein S21	rpsU	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:1990904	-	ko:K02970	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S21
SHD2_k127_7560602_160	273526.SMDB11_1074	2.87e-43	164.0	2DQF9@1|root,336H4@2|Bacteria,1N5N6@1224|Proteobacteria,1T0NC@1236|Gammaproteobacteria,405Q9@613|Serratia	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_7560602_121	189753.AXAS01000020_gene1659	8.519e-73	252.0	COG0494@1|root,COG0494@2|Bacteria,1MWBQ@1224|Proteobacteria,2TVWJ@28211|Alphaproteobacteria,3JSVC@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	NTP pyrophosphohydrolases including oxidative damage repair enzymes	MA20_42045	-	-	-	-	-	-	-	-	-	-	-	NUDIX
SHD2_k127_7560602_146	1247963.JPHU01000012_gene924	7.907e-49	196.0	COG1668@1|root,COG1668@2|Bacteria,1R62N@1224|Proteobacteria,2U1RZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	CP	COG1668 ABC-type Na efflux pump, permease component	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
SHD2_k127_7560602_89	1247963.JPHU01000012_gene925	2.155e-90	307.0	COG4152@1|root,COG4152@2|Bacteria,1QUPV@1224|Proteobacteria,2TWB4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	abc transporter atp-binding protein	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
SHD2_k127_7560602_142	1282876.BAOK01000001_gene1025	1.009e-56	204.0	COG2345@1|root,COG2345@2|Bacteria,1RDXT@1224|Proteobacteria,2U1K1@28211|Alphaproteobacteria,4BQJ6@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_11,HTH_5,MarR_2,PadR,Replic_Relax
SHD2_k127_7560602_51	331869.BAL199_14120	6.906e-130	432.0	COG2146@1|root,COG2146@2|Bacteria	2|Bacteria	P	nitrite reductase [NAD(P)H] activity	-	-	-	ko:K15762	ko00623,ko00920,ko01100,ko01120,ko01220,map00623,map00920,map01100,map01120,map01220	M00538	R02550,R03562,R05666,R09513	RC00269,RC00490,RC02556	ko00000,ko00001,ko00002	-	-	-	Glu_synthase,Rieske
SHD2_k127_7560602_223	1173020.Cha6605_2235	9.893e-07	57.0	2ESZ4@1|root,33KHC@2|Bacteria,1GDJQ@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_7560602_87	335659.S23_31610	2.244e-93	316.0	COG1230@1|root,COG1230@2|Bacteria,1MVQB@1224|Proteobacteria,2TSE3@28211|Alphaproteobacteria,3JS0H@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Cation efflux family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux
SHD2_k127_7560602_123	935557.ATYB01000010_gene557	5.413e-70	243.0	COG0580@1|root,COG0580@2|Bacteria,1PPTN@1224|Proteobacteria,2TW8M@28211|Alphaproteobacteria,4B92I@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Belongs to the MIP aquaporin (TC 1.A.8) family	aqpZ	-	-	-	-	-	-	-	-	-	-	-	MIP
SHD2_k127_7560602_125	1144312.PMI09_04118	1.455e-68	237.0	COG0394@1|root,COG0394@2|Bacteria,1MWYQ@1224|Proteobacteria,2TU1U@28211|Alphaproteobacteria,4BBYM@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Belongs to the low molecular weight phosphotyrosine protein phosphatase family	arsC1	-	1.20.4.1	ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
SHD2_k127_7560602_158	1297863.APJF01000010_gene3119	6.012e-44	167.0	COG0346@1|root,COG0346@2|Bacteria,1RHIV@1224|Proteobacteria,2TR4K@28211|Alphaproteobacteria,3JY40@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
SHD2_k127_7560602_176	1122604.JONR01000003_gene1486	1.001e-32	130.0	COG0640@1|root,COG0640@2|Bacteria,1MZAU@1224|Proteobacteria,1S8YH@1236|Gammaproteobacteria,1X7HD@135614|Xanthomonadales	135614|Xanthomonadales	K	transcriptional regulators	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_20
SHD2_k127_7560602_73	1397284.AYMN01000069_gene2032	5.997e-103	342.0	COG2175@1|root,COG2175@2|Bacteria,1MV5K@1224|Proteobacteria,1RQRU@1236|Gammaproteobacteria,401K8@613|Serratia	1236|Gammaproteobacteria	Q	Catalyzes the conversion of taurine (2-aminoethanesulfonate) to sulfite and aminoacetaldehyde concurrently with the conversion of alpha-ketoglutarate to succinate and carbon dioxide	tauD	GO:0000907,GO:0000908,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006790,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016491,GO:0016705,GO:0016706,GO:0044237,GO:0044248,GO:0044273,GO:0044424,GO:0044464,GO:0051213,GO:0055114	1.14.11.17	ko:K03119	ko00430,ko00920,map00430,map00920	-	R05320	RC01331	ko00000,ko00001,ko01000	-	-	iB21_1397.B21_00322,iECBD_1354.ECBD_3293,iECB_1328.ECB_00318,iECD_1391.ECD_00318,iECH74115_1262.ECH74115_0443,iECSP_1301.ECSP_0431,iECs_1301.ECs0422,iETEC_1333.ETEC_0422,iEcolC_1368.EcolC_3260,iG2583_1286.G2583_0480,iJN746.PP_0230,iZ_1308.Z0467	TauD
SHD2_k127_7560602_56	402881.Plav_2636	2.656e-124	404.0	COG1024@1|root,COG1024@2|Bacteria,1MWF6@1224|Proteobacteria,2TVBC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	enoyl-CoA hydratase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
SHD2_k127_7560602_96	402881.Plav_2568	3.685e-85	292.0	COG1338@1|root,COG1338@2|Bacteria,1MVBU@1224|Proteobacteria,2TT93@28211|Alphaproteobacteria,1JNT4@119043|Rhodobiaceae	28211|Alphaproteobacteria	N	Plays a role in the flagellum-specific transport system	fliP	-	-	ko:K02419	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	FliP
SHD2_k127_7560602_209	1333998.M2A_1224	9.035e-15	78.0	COG3190@1|root,COG3190@2|Bacteria,1PKVQ@1224|Proteobacteria,2UZHJ@28211|Alphaproteobacteria,4BSVE@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	N	Flagellar biosynthesis protein, FliO	-	-	-	-	-	-	-	-	-	-	-	-	FliO
SHD2_k127_7560602_196	1333998.M2A_1223	1.31e-22	102.0	COG1815@1|root,COG1815@2|Bacteria,1N1G1@1224|Proteobacteria,2UCJ4@28211|Alphaproteobacteria,4BQY6@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	N	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body	flgB	-	-	ko:K02387	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod
SHD2_k127_7560602_145	1282876.BAOK01000001_gene1543	3.041e-50	181.0	COG1558@1|root,COG1558@2|Bacteria,1RHI3@1224|Proteobacteria,2U94I@28211|Alphaproteobacteria,4BQEP@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	N	Flagellar basal body rod FlgEFG protein C-terminal	flgC	-	-	ko:K02388	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
SHD2_k127_7560602_213	269796.Rru_A2824	5.289e-13	72.0	COG1677@1|root,COG1677@2|Bacteria,1N7KU@1224|Proteobacteria,2UF4S@28211|Alphaproteobacteria,2JTWD@204441|Rhodospirillales	204441|Rhodospirillales	N	Flagellar hook-basal body	fliE	-	-	ko:K02408	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliE
SHD2_k127_7560602_201	1161401.ASJA01000004_gene2324	4.174e-20	92.0	COG1987@1|root,COG1987@2|Bacteria,1N73W@1224|Proteobacteria,2UBX6@28211|Alphaproteobacteria,43YFP@69657|Hyphomonadaceae	28211|Alphaproteobacteria	N	Flagellar biosynthesis	fliQ	-	-	ko:K02420	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_3
SHD2_k127_7560602_131	402881.Plav_2574	9.761e-64	227.0	COG1684@1|root,COG1684@2|Bacteria,1NIF4@1224|Proteobacteria,2TTHN@28211|Alphaproteobacteria,1JPBZ@119043|Rhodobiaceae	28211|Alphaproteobacteria	N	Bacterial export proteins, family 1	fliR	-	-	ko:K02421	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_1
SHD2_k127_7560602_70	189753.AXAS01000048_gene7061	8.85e-105	351.0	COG1377@1|root,COG1377@2|Bacteria,1MUWI@1224|Proteobacteria,2TS13@28211|Alphaproteobacteria,3JRW6@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	N	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin	flhB	-	-	ko:K02401	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_2
SHD2_k127_7560602_35	402881.Plav_2576	2.186e-156	517.0	COG3437@1|root,COG4191@1|root,COG3437@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria,1JNMS@119043|Rhodobiaceae	28211|Alphaproteobacteria	T	His Kinase A (phosphoacceptor) domain	cckA	-	2.7.13.3	ko:K13587	ko02020,ko04112,map02020,map04112	M00512	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_8,PAS_9,Response_reg
SHD2_k127_7560602_30	114615.BRADO4985	2.509e-171	543.0	COG0468@1|root,COG0468@2|Bacteria,1MU3C@1224|Proteobacteria,2TRPR@28211|Alphaproteobacteria,3JR81@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0071496	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
SHD2_k127_7560602_1	1122962.AULH01000007_gene1939	0.0	1151.0	COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,2TQV4@28211|Alphaproteobacteria,36XID@31993|Methylocystaceae	28211|Alphaproteobacteria	J	Threonyl and Alanyl tRNA synthetase second additional domain	alaS	GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
SHD2_k127_7560602_92	1333998.M2A_1213	3.538e-89	312.0	COG0664@1|root,COG0664@2|Bacteria,1QU34@1224|Proteobacteria,2TVH6@28211|Alphaproteobacteria,4BRRE@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	T	Ion channel	-	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0042802,GO:0044464,GO:0071944	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans,Ion_trans_2,cNMP_binding
SHD2_k127_7560602_168	323097.Nham_1622	4.554e-38	147.0	COG0346@1|root,COG0346@2|Bacteria,1RDQV@1224|Proteobacteria,2VEQV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
SHD2_k127_7560602_10	1122962.AULH01000007_gene1945	2.471e-241	749.0	COG0538@1|root,COG0538@2|Bacteria,1MUIB@1224|Proteobacteria,2TQWD@28211|Alphaproteobacteria,36XUQ@31993|Methylocystaceae	28211|Alphaproteobacteria	C	Isocitrate/isopropylmalate dehydrogenase	icd	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
SHD2_k127_7560602_122	402881.Plav_2581	4.354e-72	251.0	COG0565@1|root,COG0565@2|Bacteria,1N47Y@1224|Proteobacteria,2TS8J@28211|Alphaproteobacteria,1JNU0@119043|Rhodobiaceae	28211|Alphaproteobacteria	J	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA	trmJ	-	-	ko:K02533	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF559,SpoU_methylase
SHD2_k127_7560602_182	666684.AfiDRAFT_1871	4.787e-31	135.0	COG4235@1|root,COG4235@2|Bacteria,1MY4J@1224|Proteobacteria,2TSI7@28211|Alphaproteobacteria,3JT3X@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Cytochrome c-type biogenesis protein	cycH	-	-	ko:K02200	-	-	-	-	ko00000	-	-	-	TPR_16,TPR_19
SHD2_k127_7560602_203	1415755.JQLV01000001_gene4289	3.791e-19	90.0	2EU9P@1|root,33MS3@2|Bacteria,1NNA1@1224|Proteobacteria,1SHYE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_7560602_101	1510531.JQJJ01000008_gene3376	8.614e-83	282.0	COG1058@1|root,COG1058@2|Bacteria,1MVG6@1224|Proteobacteria,2TU5C@28211|Alphaproteobacteria,3JR92@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Probable molybdopterin binding domain	cinA1	-	-	-	-	-	-	-	-	-	-	-	MoCF_biosynth
SHD2_k127_7560602_52	1121948.AUAC01000002_gene1272	4.156e-129	417.0	COG0024@1|root,COG0024@2|Bacteria,1MU99@1224|Proteobacteria,2TQTH@28211|Alphaproteobacteria,43WNA@69657|Hyphomonadaceae	28211|Alphaproteobacteria	E	Methionine aminopeptidase	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
SHD2_k127_7560602_80	1333998.M2A_1194	7.209e-96	319.0	COG2003@1|root,COG2003@2|Bacteria,1MXZ5@1224|Proteobacteria,2TQXM@28211|Alphaproteobacteria,4BPZB@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	RadC-like JAB domain	radC	-	-	ko:K03630	-	-	-	-	ko00000	-	-	-	RadC
SHD2_k127_7560602_231	1198114.AciX9_2271	0.0003226	51.0	2F2PW@1|root,33VKA@2|Bacteria,3Y814@57723|Acidobacteria,2JN19@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_7560602_232	1122997.AUDD01000012_gene1972	0.0009439	51.0	COG0601@1|root,COG0601@2|Bacteria,2GK0Z@201174|Actinobacteria,4DPAR@85009|Propionibacteriales	201174|Actinobacteria	EP	Binding-protein-dependent transport system inner membrane component	oppB4	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
SHD2_k127_7560602_198	1225184.ALXE01000047_gene411	1.388e-21	106.0	COG1173@1|root,COG1173@2|Bacteria,1MUG4@1224|Proteobacteria,1RZ9K@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	COG1173 ABC-type dipeptide oligopeptide nickel transport systems permease components	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
SHD2_k127_7560602_227	1118153.MOY_05701	1.102e-05	49.0	COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,1RMEI@1236|Gammaproteobacteria,1XH9W@135619|Oceanospirillales	135619|Oceanospirillales	P	Belongs to the ABC transporter superfamily	oppF	-	-	ko:K13896	ko02010,map02010	M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.21,3.A.1.5.24	-	-	ABC_tran,oligo_HPY
SHD2_k127_7560602_163	909613.UO65_0678	1.326e-40	169.0	COG1123@1|root,COG4172@2|Bacteria,2H3HY@201174|Actinobacteria,4DYSE@85010|Pseudonocardiales	201174|Actinobacteria	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
SHD2_k127_7560602_15	460265.Mnod_7577	4.168e-208	654.0	COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,2TQUE@28211|Alphaproteobacteria,1JRU4@119045|Methylobacteriaceae	28211|Alphaproteobacteria	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	purB	GO:0003674,GO:0003824,GO:0004018,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016840,GO:0016842,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046033,GO:0046390,GO:0046483,GO:0055086,GO:0070626,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
SHD2_k127_7560602_90	1122604.JONR01000059_gene1133	4.233e-90	302.0	COG1853@1|root,COG1853@2|Bacteria,1MUPP@1224|Proteobacteria,1RR4T@1236|Gammaproteobacteria,1X3VQ@135614|Xanthomonadales	135614|Xanthomonadales	S	Flavin reductase like domain	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
SHD2_k127_7560602_191	1123366.TH3_17759	7.02e-26	109.0	COG4095@1|root,COG4095@2|Bacteria,1N759@1224|Proteobacteria,2UG31@28211|Alphaproteobacteria,2JUVA@204441|Rhodospirillales	204441|Rhodospirillales	S	PQ loop repeat	-	-	-	ko:K15383	-	-	-	-	ko00000,ko02000	9.A.58.2	-	-	PQ-loop
SHD2_k127_7560602_34	1333998.M2A_2721	1.183e-156	508.0	COG2124@1|root,COG2124@2|Bacteria,1MV8Q@1224|Proteobacteria,2TRWW@28211|Alphaproteobacteria,4BR2E@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	Q	Cytochrome P450	-	-	-	-	-	-	-	-	-	-	-	-	p450
SHD2_k127_7560602_13	1333998.M2A_1200	1.113e-218	697.0	COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2TQMV@28211|Alphaproteobacteria,4BQR9@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	G	PQQ-like domain	-	-	1.1.5.2	ko:K00117	ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130	-	R06620	RC00066	ko00000,ko00001,ko01000	-	-	-	PQQ,PQQ_2
SHD2_k127_7560602_184	314254.OA2633_04666	6.384e-30	121.0	COG5467@1|root,COG5467@2|Bacteria,1MZRN@1224|Proteobacteria,2UC1G@28211|Alphaproteobacteria,43Y73@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DUF1476)	MA20_09035	-	-	-	-	-	-	-	-	-	-	-	DUF1476
SHD2_k127_7560602_53	391165.GbCGDNIH1_1666	8.471e-129	417.0	COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,2TR8D@28211|Alphaproteobacteria,2JPK8@204441|Rhodospirillales	204441|Rhodospirillales	F	Belongs to the SAICAR synthetase family	purC	-	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
SHD2_k127_7560602_183	1287276.X752_20730	3.877e-30	122.0	COG1828@1|root,COG1828@2|Bacteria,1N83G@1224|Proteobacteria,2UF7S@28211|Alphaproteobacteria,43KV4@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purS	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	PurS
SHD2_k127_7560602_83	648757.Rvan_0441	9.975e-95	314.0	COG0047@1|root,COG0047@2|Bacteria,1MU4Y@1224|Proteobacteria,2TS67@28211|Alphaproteobacteria,3N6NC@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purQ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
SHD2_k127_7560602_3	1411123.JQNH01000001_gene16	0.0	1020.0	COG0046@1|root,COG0046@2|Bacteria,1MYN4@1224|Proteobacteria,2TRGM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
SHD2_k127_7560602_189	1238182.C882_1356	4.46e-26	108.0	COG0271@1|root,COG0271@2|Bacteria,1R3MM@1224|Proteobacteria,2UBUW@28211|Alphaproteobacteria,2JTE0@204441|Rhodospirillales	204441|Rhodospirillales	T	Belongs to the BolA IbaG family	-	-	-	-	-	-	-	-	-	-	-	-	BolA
SHD2_k127_7560602_105	936455.KI421499_gene4842	9.379e-82	284.0	COG5459@1|root,COG5459@2|Bacteria,1MWMM@1224|Proteobacteria,2TQX8@28211|Alphaproteobacteria,3JT6V@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	J	Mitochondrial small ribosomal subunit Rsm22	-	-	-	-	-	-	-	-	-	-	-	-	Rsm22
SHD2_k127_7560602_157	414684.RC1_0986	4.473e-44	163.0	COG0278@1|root,COG0278@2|Bacteria,1MZ4V@1224|Proteobacteria,2U9QB@28211|Alphaproteobacteria,2JSSH@204441|Rhodospirillales	204441|Rhodospirillales	O	Belongs to the glutaredoxin family. Monothiol subfamily	-	-	-	ko:K07390	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Glutaredoxin
SHD2_k127_7560602_84	570967.JMLV01000007_gene964	5.72e-94	323.0	COG0778@1|root,COG0778@2|Bacteria,1NTK9@1224|Proteobacteria,2TR3E@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
SHD2_k127_7560602_88	631454.N177_0273	8.163e-92	306.0	COG0522@1|root,COG0522@2|Bacteria,1MW0U@1224|Proteobacteria,2TRQH@28211|Alphaproteobacteria,1JN0F@119043|Rhodobiaceae	28211|Alphaproteobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
SHD2_k127_7560602_199	521674.Plim_0348	3.394e-21	100.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
SHD2_k127_7560602_107	1430440.MGMSRv2_1590	2.484e-80	283.0	COG0628@1|root,COG0628@2|Bacteria,1NG06@1224|Proteobacteria,2U3ZI@28211|Alphaproteobacteria,2JSBH@204441|Rhodospirillales	204441|Rhodospirillales	S	Transmembrane protein 43	-	-	-	-	-	-	-	-	-	-	-	-	TMEM43
SHD2_k127_7560602_64	1313172.YM304_41520	2.199e-114	377.0	COG5285@1|root,COG5285@2|Bacteria,2GNXP@201174|Actinobacteria	201174|Actinobacteria	Q	Phytanoyl-CoA dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	PhyH
SHD2_k127_7560602_50	1382303.JPOM01000001_gene43	4.379e-130	419.0	COG1024@1|root,COG1024@2|Bacteria,1PK10@1224|Proteobacteria,2TS4M@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
SHD2_k127_7560602_8	1123073.KB899242_gene925	4.886e-267	839.0	COG3590@1|root,COG3590@2|Bacteria,1MVNQ@1224|Proteobacteria,1RNNA@1236|Gammaproteobacteria,1X4B6@135614|Xanthomonadales	135614|Xanthomonadales	O	peptidase	-	-	-	ko:K07386	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M13,Peptidase_M13_N
SHD2_k127_7560602_119	420662.Mpe_A0974	2.371e-73	255.0	COG3836@1|root,COG3836@2|Bacteria,1MUSG@1224|Proteobacteria,2VN7W@28216|Betaproteobacteria,1KIZJ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Belongs to the HpcH HpaI aldolase family	-	-	4.1.2.52	ko:K02510	ko00350,ko01120,map00350,map01120	-	R01645,R01647	RC00307,RC00572,RC00574,RC03057	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
SHD2_k127_7560602_45	1336243.JAEA01000011_gene3207	1.429e-139	454.0	COG0654@1|root,COG0654@2|Bacteria,1P1NX@1224|Proteobacteria,2TRZX@28211|Alphaproteobacteria,1JTU0@119045|Methylobacteriaceae	28211|Alphaproteobacteria	CH	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
SHD2_k127_7560602_159	1282876.BAOK01000001_gene3434	1.433e-43	163.0	COG1917@1|root,COG1917@2|Bacteria,1RB86@1224|Proteobacteria	1224|Proteobacteria	S	PFAM Cupin 2 conserved barrel domain protein	-	-	1.13.11.41	ko:K05913	ko00363,ko01120,map00363,map01120	-	R01305	RC00415,RC01565	ko00000,ko00001,ko01000	-	-	-	Cupin_7
SHD2_k127_7560602_81	1123240.ATVO01000003_gene41	8.136e-96	330.0	COG1028@1|root,COG1028@2|Bacteria,1R413@1224|Proteobacteria,2TW0W@28211|Alphaproteobacteria,2KDTR@204457|Sphingomonadales	204457|Sphingomonadales	IQ	Short-chain dehydrogenase reductase sdr	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
SHD2_k127_7560602_200	82995.CR62_16870	9.735e-21	98.0	COG0454@1|root,COG0456@2|Bacteria,1RIF2@1224|Proteobacteria,1S7KH@1236|Gammaproteobacteria,4035Y@613|Serratia	1236|Gammaproteobacteria	K	Acetyltransferase (GNAT) domain	yjaB_1	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_7
SHD2_k127_7560602_19	1187851.A33M_0602	5.374e-196	620.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2TRN7@28211|Alphaproteobacteria,3FCGE@34008|Rhodovulum	28211|Alphaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	lpdA	GO:0000166,GO:0003674,GO:0003824,GO:0004148,GO:0005488,GO:0005507,GO:0005524,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005746,GO:0005747,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0009507,GO:0009536,GO:0010035,GO:0010038,GO:0016020,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0017076,GO:0019866,GO:0030554,GO:0030964,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0045271,GO:0046686,GO:0046872,GO:0046914,GO:0048046,GO:0050896,GO:0050897,GO:0055114,GO:0070469,GO:0097159,GO:0097367,GO:0098796,GO:0098798,GO:0098800,GO:0098803,GO:1901265,GO:1901363,GO:1902494,GO:1990204	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
SHD2_k127_7560602_226	1449065.JMLL01000010_gene1475	1.05e-05	52.0	COG4575@1|root,COG4575@2|Bacteria,1NGZU@1224|Proteobacteria,2UJGB@28211|Alphaproteobacteria,43KSC@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Bacterial protein of unknown function (DUF883)	-	-	-	-	-	-	-	-	-	-	-	-	DUF883
SHD2_k127_7560602_71	1304877.KI519399_gene6201	1.273e-104	360.0	COG1807@1|root,COG1807@2|Bacteria,1P6JE@1224|Proteobacteria,2TV39@28211|Alphaproteobacteria,3JQTU@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	MA20_09520	-	-	-	-	-	-	-	-	-	-	-	PMT_2
SHD2_k127_7560602_48	652103.Rpdx1_1560	1.241e-131	430.0	COG0463@1|root,COG2246@1|root,COG0463@2|Bacteria,COG2246@2|Bacteria,1MV8J@1224|Proteobacteria,2TTYF@28211|Alphaproteobacteria,3JQXI@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	GtrA-like protein	MA20_09515	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2,GtrA
SHD2_k127_7560602_5	1292034.OR37_03842	2.848e-299	934.0	COG2366@1|root,COG2366@2|Bacteria,1MVMH@1224|Proteobacteria,2TS4D@28211|Alphaproteobacteria,2KG74@204458|Caulobacterales	204458|Caulobacterales	S	Penicillin amidase	-	-	3.5.1.11,3.5.1.97	ko:K01434,ko:K07116	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
SHD2_k127_7560602_156	349102.Rsph17025_2937	2.803e-44	166.0	COG2907@1|root,COG2907@2|Bacteria,1MV4Z@1224|Proteobacteria,2TQUH@28211|Alphaproteobacteria,1FCI4@1060|Rhodobacter	28211|Alphaproteobacteria	S	Flavin containing amine oxidoreductase	-	-	-	ko:K06954	-	-	-	-	ko00000	-	-	-	Amino_oxidase
SHD2_k127_7560602_63	856793.MICA_2205	1.814e-114	389.0	COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,2TR8K@28211|Alphaproteobacteria,4BPH3@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	M	synthase	cfa_2	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
SHD2_k127_7560602_25	331869.BAL199_09705	5.471e-177	569.0	COG0477@1|root,COG0477@2|Bacteria,1RGPN@1224|Proteobacteria,2TQKW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EGP	Major facilitator Superfamily	-	-	-	ko:K03446	-	M00701	-	-	ko00000,ko00002,ko02000	2.A.1.3	-	-	MFS_1
SHD2_k127_7560602_138	2880.D7FNV7	3.569e-59	220.0	2CXPI@1|root,2RYW0@2759|Eukaryota	2759|Eukaryota	S	Fatty acid desaturase	-	-	-	-	-	-	-	-	-	-	-	-	FA_desaturase
SHD2_k127_7560602_143	1380394.JADL01000005_gene5562	1.449e-55	202.0	COG1755@1|root,COG1755@2|Bacteria,1RERZ@1224|Proteobacteria,2U77M@28211|Alphaproteobacteria,2JT6I@204441|Rhodospirillales	204441|Rhodospirillales	S	Isoprenylcysteine carboxyl methyltransferase (ICMT) family	-	-	-	ko:K16168	-	-	-	-	ko00000,ko01008	-	-	-	ICMT
SHD2_k127_7560602_49	1380394.JADL01000005_gene5561	3.652e-130	423.0	COG3424@1|root,COG3424@2|Bacteria,1MUDX@1224|Proteobacteria,2TRTX@28211|Alphaproteobacteria,2JPDM@204441|Rhodospirillales	204441|Rhodospirillales	Q	Chalcone and stilbene synthases, C-terminal domain	-	-	-	ko:K16167	-	-	-	-	ko00000,ko01008	-	-	-	Chal_sti_synt_C,Chal_sti_synt_N
SHD2_k127_7560602_165	1156935.QWE_22786	9.563e-40	158.0	COG2771@1|root,COG2771@2|Bacteria,1N6UR@1224|Proteobacteria,2V8KR@28211|Alphaproteobacteria,4BE51@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	COG2771 DNA-binding HTH domain-containing proteins	-	-	-	-	-	-	-	-	-	-	-	-	Autoind_bind,GerE
SHD2_k127_7560602_66	1449076.JOOE01000001_gene2042	9.451e-113	373.0	COG5285@1|root,COG5285@2|Bacteria,1MXBX@1224|Proteobacteria,2U4PZ@28211|Alphaproteobacteria,2KDE0@204457|Sphingomonadales	204457|Sphingomonadales	Q	Protein involved in biosynthesis of mitomycin antibiotics polyketide fumonisin	-	-	-	-	-	-	-	-	-	-	-	-	PhyH
SHD2_k127_7560602_152	627192.SLG_19630	2.413e-45	171.0	COG3916@1|root,COG3916@2|Bacteria,1Q9F2@1224|Proteobacteria,2UFP1@28211|Alphaproteobacteria,2K48R@204457|Sphingomonadales	204457|Sphingomonadales	H	Autoinducer synthase	-	-	2.3.1.228,2.3.1.229	ko:K18096	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000	-	-	-	Autoind_synth
SHD2_k127_7560602_140	1248916.ANFY01000005_gene2729	9.565e-59	213.0	COG2197@1|root,COG2197@2|Bacteria,1N0K2@1224|Proteobacteria,2UENQ@28211|Alphaproteobacteria,2K20S@204457|Sphingomonadales	204457|Sphingomonadales	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Autoind_bind,GerE
SHD2_k127_7560602_39	366602.Caul_3065	2.672e-152	486.0	COG0604@1|root,COG0604@2|Bacteria,1MWRK@1224|Proteobacteria,2U14P@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Alcohol dehydrogenase zinc-binding domain protein	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
SHD2_k127_7560602_22	652103.Rpdx1_0544	1.226e-184	585.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TQQ7@28211|Alphaproteobacteria,3JSVS@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Belongs to the thiolase family	pcaF	-	2.3.1.174	ko:K07823	ko00362,ko01120,map00362,map01120	-	R00829	RC00004,RC00326	ko00000,ko00001,ko01000	-	-	-	Thiolase_C,Thiolase_N
SHD2_k127_7560602_190	1116369.KB890024_gene2792	4.901e-26	114.0	COG1917@1|root,COG1917@2|Bacteria,1RHMM@1224|Proteobacteria,2U9W3@28211|Alphaproteobacteria,43MGY@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
SHD2_k127_7560602_114	443906.CMM_0950	2.361e-75	258.0	COG2258@1|root,COG2258@2|Bacteria,2GMBE@201174|Actinobacteria,4FNXJ@85023|Microbacteriaceae	201174|Actinobacteria	S	MOSC domain	-	-	-	-	-	-	-	-	-	-	-	-	MOSC
SHD2_k127_7560602_211	983545.Glaag_0783	1.141e-14	83.0	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
SHD2_k127_7560602_44	517722.AEUE01000001_gene2674	3.785e-141	458.0	COG2159@1|root,COG2159@2|Bacteria,1MVTS@1224|Proteobacteria,2VGQX@28211|Alphaproteobacteria,2KE5I@204457|Sphingomonadales	204457|Sphingomonadales	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
SHD2_k127_7560602_33	59538.XP_005974719.1	8.128e-159	508.0	COG1960@1|root,KOG0141@2759|Eukaryota,38CQN@33154|Opisthokonta,3BAWC@33208|Metazoa,3CTM0@33213|Bilateria,4808A@7711|Chordata,48YSQ@7742|Vertebrata,3JC6P@40674|Mammalia,4J50Y@91561|Cetartiodactyla	2759|Eukaryota	EI	isovaleryl-CoA dehydrogenase	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
SHD2_k127_7560602_28	1090320.KB900605_gene2236	2.488e-173	552.0	COG1960@1|root,COG1960@2|Bacteria,1MVJC@1224|Proteobacteria,2TUVB@28211|Alphaproteobacteria,2K24U@204457|Sphingomonadales	204457|Sphingomonadales	I	Acyl-CoA dehydrogenase, middle domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
SHD2_k127_7560602_29	1090320.KB900605_gene2236	5.095e-173	551.0	COG1960@1|root,COG1960@2|Bacteria,1MVJC@1224|Proteobacteria,2TUVB@28211|Alphaproteobacteria,2K24U@204457|Sphingomonadales	204457|Sphingomonadales	I	Acyl-CoA dehydrogenase, middle domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
SHD2_k127_7560602_18	59538.XP_005968785.1	1.668e-196	619.0	COG1960@1|root,KOG0141@2759|Eukaryota,39Q3X@33154|Opisthokonta	33154|Opisthokonta	EI	Acyl-CoA dehydrogenase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
SHD2_k127_7560602_12	450851.PHZ_c1112	5.128e-227	736.0	COG0612@1|root,COG0612@2|Bacteria,1NAH6@1224|Proteobacteria,2U0S5@28211|Alphaproteobacteria,2KFX1@204458|Caulobacterales	204458|Caulobacterales	S	Belongs to the peptidase M16 family	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
SHD2_k127_7560602_7	1205680.CAKO01000029_gene5245	4.258e-267	829.0	COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,2TSE2@28211|Alphaproteobacteria,2JQ6Q@204441|Rhodospirillales	204441|Rhodospirillales	E	COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases	-	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
SHD2_k127_7560602_0	1205680.CAKO01000029_gene5246	0.0	2524.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,2TRHQ@28211|Alphaproteobacteria,2JPK2@204441|Rhodospirillales	204441|Rhodospirillales	E	glutamate synthase	-	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
SHD2_k127_7560602_37	1282876.BAOK01000002_gene352	1.377e-154	509.0	COG5002@1|root,COG5002@2|Bacteria,1NUDM@1224|Proteobacteria,2URDM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
SHD2_k127_7560602_102	1163407.UU7_03612	1.05e-82	289.0	2C8CD@1|root,2Z9AD@2|Bacteria,1N17D@1224|Proteobacteria,1RRIP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_7560602_204	1161401.ASJA01000009_gene1833	1.117e-18	90.0	COG3794@1|root,COG3794@2|Bacteria,1RE6B@1224|Proteobacteria,2UAER@28211|Alphaproteobacteria,440HV@69657|Hyphomonadaceae	28211|Alphaproteobacteria	C	Cupredoxin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cupredoxin_1
SHD2_k127_7560602_68	91464.S7335_89	7.6e-108	365.0	COG2267@1|root,COG2267@2|Bacteria,1GH9H@1117|Cyanobacteria,1H3V0@1129|Synechococcus	1117|Cyanobacteria	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_7560602_170	883078.HMPREF9695_02303	9.324e-38	146.0	2CWCM@1|root,32SZF@2|Bacteria,1N037@1224|Proteobacteria,2UCWU@28211|Alphaproteobacteria,3JYW3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DUF4260)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4260
SHD2_k127_7560602_154	394221.Mmar10_0744	6.442e-45	171.0	arCOG09454@1|root,30G4A@2|Bacteria,1N61J@1224|Proteobacteria,2UEFT@28211|Alphaproteobacteria,43YIZ@69657|Hyphomonadaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_7560602_132	402881.Plav_2558	1.78e-62	218.0	COG1734@1|root,COG1734@2|Bacteria,1RD08@1224|Proteobacteria,2U74V@28211|Alphaproteobacteria,1JNZC@119043|Rhodobiaceae	28211|Alphaproteobacteria	T	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters	dksA	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
SHD2_k127_7560602_120	402881.Plav_2559	5.286e-73	259.0	COG2063@1|root,COG2063@2|Bacteria,1RDEY@1224|Proteobacteria,2TRHN@28211|Alphaproteobacteria,1JP2T@119043|Rhodobiaceae	28211|Alphaproteobacteria	N	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation	flgH	-	-	ko:K02393	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlgH
SHD2_k127_7560602_216	1123355.JHYO01000011_gene1530	1.595e-11	72.0	COG1261@1|root,COG1261@2|Bacteria,1PM4C@1224|Proteobacteria,2TRUS@28211|Alphaproteobacteria,36YU6@31993|Methylocystaceae	28211|Alphaproteobacteria	NO	SAF	flgA	-	-	ko:K02386	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	ChapFlgA
SHD2_k127_7560602_75	402881.Plav_2561	1.679e-100	333.0	COG4786@1|root,COG4786@2|Bacteria,1MVMA@1224|Proteobacteria,2TRR4@28211|Alphaproteobacteria,1JNRD@119043|Rhodobiaceae	28211|Alphaproteobacteria	N	Flagellar basal body rod FlgEFG protein C-terminal	flgG	-	-	ko:K02392	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
SHD2_k127_7560602_139	1502724.FF80_01408	6.96e-59	215.0	COG4786@1|root,COG4786@2|Bacteria,1PZ24@1224|Proteobacteria,2U06G@28211|Alphaproteobacteria,3N74A@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	N	Belongs to the flagella basal body rod proteins family	flgF	-	-	ko:K02391,ko:K02392	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
SHD2_k127_7560602_177	1380394.JADL01000014_gene255	1.808e-32	134.0	COG1580@1|root,COG1580@2|Bacteria,1RH5D@1224|Proteobacteria,2U9BF@28211|Alphaproteobacteria,2JST8@204441|Rhodospirillales	204441|Rhodospirillales	N	Controls the rotational direction of flagella during chemotaxis	fliL	-	-	ko:K02415	-	-	-	-	ko00000,ko02035	-	-	-	FliL
SHD2_k127_7560602_31	1282362.AEAC466_03480	2.84e-165	526.0	COG1868@1|root,COG1868@2|Bacteria,1MX01@1224|Proteobacteria,2TR4F@28211|Alphaproteobacteria,2KFGT@204458|Caulobacterales	204458|Caulobacterales	N	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation	fliM	-	-	ko:K02416	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliM,FliMN_C
SHD2_k127_7560602_220	1122962.AULH01000007_gene1922	1.458e-07	63.0	2A6BI@1|root,30V4A@2|Bacteria,1RAJ5@1224|Proteobacteria,2U5D4@28211|Alphaproteobacteria,370J6@31993|Methylocystaceae	28211|Alphaproteobacteria	-	-	MA20_08455	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_7560602_185	582402.Hbal_0534	1.804e-28	130.0	COG3334@1|root,COG3334@2|Bacteria,1RKF6@1224|Proteobacteria,2TRR1@28211|Alphaproteobacteria,43YP5@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	PFAM MgtE intracellular	MA20_08460	-	-	-	-	-	-	-	-	-	-	-	MgtE_N
SHD2_k127_7560602_41	652103.Rpdx1_1457	3.062e-147	509.0	COG0457@1|root,COG0457@2|Bacteria,1N09H@1224|Proteobacteria,2TSKT@28211|Alphaproteobacteria,3JS1S@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_7560602_133	1232437.KL662050_gene5382	1.42e-61	223.0	COG2267@1|root,COG2267@2|Bacteria,1PWD1@1224|Proteobacteria,43919@68525|delta/epsilon subdivisions,2X46M@28221|Deltaproteobacteria,2MPCU@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
SHD2_k127_7560602_136	414684.RC1_3408	2.889e-60	215.0	COG1051@1|root,COG1051@2|Bacteria,1QU0T@1224|Proteobacteria,2TW25@28211|Alphaproteobacteria,2JSS3@204441|Rhodospirillales	204441|Rhodospirillales	F	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage	nudH	-	-	ko:K08311	ko03018,map03018	-	R10816	RC00002	ko00000,ko00001,ko01000,ko03019	-	-	-	NUDIX
SHD2_k127_7560602_124	1411123.JQNH01000001_gene3904	5.39e-69	247.0	COG2861@1|root,COG2861@2|Bacteria,1N3JP@1224|Proteobacteria,2TUFD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein conserved in bacteria	-	-	-	ko:K09798	-	-	-	-	ko00000	-	-	-	Polysacc_deac_2
SHD2_k127_7560602_72	744980.TRICHSKD4_1579	1.4e-104	354.0	COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,2TRW2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Belongs to the peptidase S41A family	ctpA	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_S41
SHD2_k127_7560602_43	402881.Plav_1472	2.421e-143	467.0	COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,2TRW2@28211|Alphaproteobacteria,1JNEG@119043|Rhodobiaceae	28211|Alphaproteobacteria	M	tail specific protease	ctpA	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_S41
SHD2_k127_7560602_173	1282876.BAOK01000002_gene471	1.055e-34	149.0	COG4942@1|root,COG4942@2|Bacteria,1MY3E@1224|Proteobacteria,2TUSP@28211|Alphaproteobacteria,4BQC6@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	D	Peptidase family M23	filA	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
SHD2_k127_7560602_17	1150626.PHAMO_280050	2.602e-197	628.0	COG0696@1|root,COG0696@2|Bacteria,1MUQ1@1224|Proteobacteria,2TS6R@28211|Alphaproteobacteria,2JR4Y@204441|Rhodospirillales	204441|Rhodospirillales	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmI	-	5.4.2.12	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,Phosphodiest,iPGM_N
SHD2_k127_7560602_42	693986.MOC_6132	1.404e-146	473.0	COG1706@1|root,COG1706@2|Bacteria,1MVKW@1224|Proteobacteria,2TQNX@28211|Alphaproteobacteria,1JRRG@119045|Methylobacteriaceae	28211|Alphaproteobacteria	N	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation	flgI	GO:0005575,GO:0005623,GO:0009288,GO:0009425,GO:0042597,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464	-	ko:K02394	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlgI
SHD2_k127_7560602_197	1121033.AUCF01000013_gene1662	3.783e-22	101.0	COG3951@1|root,COG3951@2|Bacteria,1N7K5@1224|Proteobacteria,2UFY2@28211|Alphaproteobacteria,2JTXF@204441|Rhodospirillales	204441|Rhodospirillales	MNO	Rod binding protein	cheL	-	-	-	-	-	-	-	-	-	-	-	Rod-binding
SHD2_k127_7560602_129	450851.PHZ_c1388	1.027e-64	251.0	COG1520@1|root,COG1520@2|Bacteria,1P31B@1224|Proteobacteria,2U4EC@28211|Alphaproteobacteria,2KFTR@204458|Caulobacterales	204458|Caulobacterales	S	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_7560602_116	1207063.P24_16175	1.844e-74	269.0	COG0457@1|root,COG0457@2|Bacteria,1MUZK@1224|Proteobacteria,2TS0U@28211|Alphaproteobacteria,2JPRT@204441|Rhodospirillales	204441|Rhodospirillales	M	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9,TPR_1,TPR_11,TPR_16,TPR_2,TPR_4,TPR_8
SHD2_k127_7560602_47	269799.Gmet_0454	1.099e-131	445.0	COG1861@1|root,COG3980@1|root,COG1861@2|Bacteria,COG3980@2|Bacteria,1R8GW@1224|Proteobacteria,42Q9K@68525|delta/epsilon subdivisions,2WKV9@28221|Deltaproteobacteria,43UDN@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase	-	-	-	ko:K07257	-	-	-	-	ko00000	-	-	-	Glyco_tran_28_C,NTP_transf_3
SHD2_k127_7560602_62	1122137.AQXF01000006_gene709	1.233e-116	385.0	COG2089@1|root,COG2089@2|Bacteria,1MWG3@1224|Proteobacteria,2TRA6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	acid synthase	-	-	2.5.1.56	ko:K01654	ko00520,ko01100,map00520,map01100	-	R01804,R04435	RC00159	ko00000,ko00001,ko01000	-	-	-	Acetyltransf_1,NeuB,SAF
SHD2_k127_7560602_85	269799.Gmet_0453	7.495e-94	318.0	COG2227@1|root,COG2227@2|Bacteria,1RKH0@1224|Proteobacteria,42Q2I@68525|delta/epsilon subdivisions,2WJME@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	PFAM Methyltransferase type	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
SHD2_k127_7560602_224	1000565.METUNv1_00934	9.986e-07	60.0	COG4424@1|root,COG4424@2|Bacteria,1QVF4@1224|Proteobacteria,2VMVK@28216|Betaproteobacteria,2KXTD@206389|Rhodocyclales	206389|Rhodocyclales	S	Sulfotransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3
SHD2_k127_7560602_221	1131269.AQVV01000008_gene943	1.491e-07	63.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_31
SHD2_k127_7560602_99	429009.Adeg_1861	8.435e-85	291.0	COG3959@1|root,COG3959@2|Bacteria,1TT51@1239|Firmicutes,247IK@186801|Clostridia,42EYC@68295|Thermoanaerobacterales	186801|Clostridia	G	PFAM Transketolase	tktA2	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
SHD2_k127_7560602_78	1121447.JONL01000002_gene1956	5.45e-99	334.0	COG3958@1|root,COG3958@2|Bacteria,1N6QF@1224|Proteobacteria,42Q04@68525|delta/epsilon subdivisions,2WKF7@28221|Deltaproteobacteria,2M9CQ@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	Transketolase central region	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
SHD2_k127_7560602_106	1121447.JONL01000002_gene1953	1.505e-81	282.0	COG1028@1|root,COG1028@2|Bacteria,1PG7I@1224|Proteobacteria,43A1P@68525|delta/epsilon subdivisions,2X25V@28221|Deltaproteobacteria,2MA3W@213115|Desulfovibrionales	28221|Deltaproteobacteria	IQ	KR domain	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
SHD2_k127_7560602_57	1121447.JONL01000002_gene1959	5.885e-124	411.0	COG0458@1|root,COG0458@2|Bacteria,1RFH4@1224|Proteobacteria,42NQ6@68525|delta/epsilon subdivisions,2WMDW@28221|Deltaproteobacteria,2M8P6@213115|Desulfovibrionales	28221|Deltaproteobacteria	EF	ATP-grasp domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_3,ATP-grasp_4,GARS_A
SHD2_k127_7560602_27	269799.Gmet_0448	8.905e-175	569.0	COG1449@1|root,COG1449@2|Bacteria,1R51R@1224|Proteobacteria,42P4W@68525|delta/epsilon subdivisions,2WK2R@28221|Deltaproteobacteria,43U1D@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	Glycosyl hydrolase family 57	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_57
SHD2_k127_7560602_97	1121022.ABENE_12000	3.862e-85	292.0	COG1344@1|root,COG1344@2|Bacteria,1MV1N@1224|Proteobacteria,2TUQQ@28211|Alphaproteobacteria,2KFYB@204458|Caulobacterales	204458|Caulobacterales	N	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella	fljM	GO:0005575,GO:0005576,GO:0005623,GO:0009288,GO:0042995,GO:0043226,GO:0043228,GO:0044464	-	ko:K02406	ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_C,Flagellin_N
SHD2_k127_7560602_93	1121022.ABENE_12000	1.087e-86	297.0	COG1344@1|root,COG1344@2|Bacteria,1MV1N@1224|Proteobacteria,2TUQQ@28211|Alphaproteobacteria,2KFYB@204458|Caulobacterales	204458|Caulobacterales	N	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella	fljM	GO:0005575,GO:0005576,GO:0005623,GO:0009288,GO:0042995,GO:0043226,GO:0043228,GO:0044464	-	ko:K02406	ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_C,Flagellin_N
SHD2_k127_7560602_188	1161401.ASJA01000004_gene2189	8.767e-28	115.0	COG5442@1|root,COG5442@2|Bacteria,1N1GT@1224|Proteobacteria,2UBRC@28211|Alphaproteobacteria,43Y4U@69657|Hyphomonadaceae	28211|Alphaproteobacteria	N	Flagellar protein FlaF	flaF	-	-	ko:K06602	-	-	-	-	ko00000,ko02035	-	-	-	FlaF
SHD2_k127_7560602_148	1479238.JQMZ01000001_gene2224	9.812e-49	178.0	COG5443@1|root,COG5443@2|Bacteria,1RD3V@1224|Proteobacteria,2U7PK@28211|Alphaproteobacteria,43XX7@69657|Hyphomonadaceae	28211|Alphaproteobacteria	N	Flagellar protein FlbT	flbT	-	-	ko:K06601	-	-	-	-	ko00000,ko02035	-	-	-	FlbT
SHD2_k127_7560602_58	551789.ATVJ01000001_gene2187	5.569e-122	415.0	COG0457@1|root,COG0457@2|Bacteria,1MUZK@1224|Proteobacteria,2TS0U@28211|Alphaproteobacteria,43WTE@69657|Hyphomonadaceae	28211|Alphaproteobacteria	M	TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_11,TPR_16,TPR_19,TPR_2,TPR_8
SHD2_k127_7560602_103	402881.Plav_1353	1.218e-82	284.0	COG2267@1|root,COG2267@2|Bacteria,1QUAA@1224|Proteobacteria,2V8R4@28211|Alphaproteobacteria,1JPRP@119043|Rhodobiaceae	28211|Alphaproteobacteria	I	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
SHD2_k127_7560602_161	1121033.AUCF01000020_gene702	3.581e-41	161.0	COG1587@1|root,COG1587@2|Bacteria,1NMTP@1224|Proteobacteria,2U1Y2@28211|Alphaproteobacteria,2JT1V@204441|Rhodospirillales	204441|Rhodospirillales	H	Uroporphyrinogen-III synthase HemD	-	-	4.2.1.75	ko:K01719	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165	RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4,Mitofilin
SHD2_k127_7560602_91	1297570.MESS4_230049	2.444e-89	306.0	COG0181@1|root,COG0181@2|Bacteria,1MU56@1224|Proteobacteria,2TS3D@28211|Alphaproteobacteria,43HQC@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	-	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	-	Porphobil_deam,Porphobil_deamC
SHD2_k127_7560602_54	439375.Oant_0974	8.525e-126	416.0	COG0533@1|root,COG0533@2|Bacteria,1MU6S@1224|Proteobacteria,2TSF7@28211|Alphaproteobacteria,1J2T5@118882|Brucellaceae	28211|Alphaproteobacteria	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360,GO:1901564	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
SHD2_k127_7560602_74	1207063.P24_03331	8.799e-102	338.0	COG0708@1|root,COG0708@2|Bacteria,1MVMC@1224|Proteobacteria,2TRWQ@28211|Alphaproteobacteria,2JQET@204441|Rhodospirillales	204441|Rhodospirillales	L	COG0708 Exonuclease III	-	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
SHD2_k127_7560602_178	402881.Plav_1292	3.428e-32	130.0	COG2050@1|root,COG2050@2|Bacteria,1RBET@1224|Proteobacteria,2U5TM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	protein, possibly involved in aromatic compounds catabolism	MA20_42425	-	-	-	-	-	-	-	-	-	-	-	4HBT
SHD2_k127_7560602_153	1089552.KI911559_gene297	5.492e-45	171.0	COG0406@1|root,COG0406@2|Bacteria,1NPC4@1224|Proteobacteria,2U9WD@28211|Alphaproteobacteria,2JSYG@204441|Rhodospirillales	204441|Rhodospirillales	G	Phosphoglycerate mutase family	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
SHD2_k127_7560602_174	1163617.SCD_n02381	1.145e-33	142.0	COG3025@1|root,COG5607@1|root,COG3025@2|Bacteria,COG5607@2|Bacteria,1MY43@1224|Proteobacteria,2VM3G@28216|Betaproteobacteria	28216|Betaproteobacteria	S	PFAM CHAD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CHAD,CYTH
SHD2_k127_7560602_59	1089552.KI911559_gene319	6.125e-121	393.0	COG0107@1|root,COG0107@2|Bacteria,1MUS0@1224|Proteobacteria,2TQXD@28211|Alphaproteobacteria,2JPAN@204441|Rhodospirillales	204441|Rhodospirillales	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	-	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
SHD2_k127_7560602_95	1282876.BAOK01000002_gene191	1.673e-86	300.0	COG1466@1|root,COG1466@2|Bacteria,1R8PA@1224|Proteobacteria,2U1KQ@28211|Alphaproteobacteria,4BQFX@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	L	DNA polymerase III, delta subunit	holA	-	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta
SHD2_k127_7560602_208	107636.JQNK01000009_gene2416	7.529e-15	82.0	COG5468@1|root,COG5468@2|Bacteria,1MXDR@1224|Proteobacteria,2TUMW@28211|Alphaproteobacteria,36YRT@31993|Methylocystaceae	28211|Alphaproteobacteria	S	Lipopolysaccharide-assembly	-	-	-	ko:K03643	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	LptE
SHD2_k127_7560602_2	1121033.AUCF01000003_gene3386	0.0	1107.0	COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,2TQPK@28211|Alphaproteobacteria,2JQAA@204441|Rhodospirillales	204441|Rhodospirillales	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
SHD2_k127_7560602_164	1110502.TMO_3423	5.12e-40	153.0	2C2J5@1|root,315UG@2|Bacteria,1RHAH@1224|Proteobacteria,2U94W@28211|Alphaproteobacteria,2JSXP@204441|Rhodospirillales	204441|Rhodospirillales	S	Domain of unknown function (DUF3576)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3576
SHD2_k127_7560602_206	1282876.BAOK01000002_gene195	4.35e-16	91.0	COG3203@1|root,COG3203@2|Bacteria,1RJ02@1224|Proteobacteria,2U9JB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Gram-negative porin	-	-	-	ko:K08720	ko01501,ko05111,map01501,map05111	-	-	-	ko00000,ko00001,ko02000	1.B.1.2.1	-	-	Porin_4
SHD2_k127_7560602_193	1292034.OR37_01739	2.891e-24	109.0	COG0352@1|root,COG0352@2|Bacteria,1N908@1224|Proteobacteria,2VEZB@28211|Alphaproteobacteria,2KJUP@204458|Caulobacterales	204458|Caulobacterales	H	Thiamine monophosphate synthase	-	-	-	-	-	-	-	-	-	-	-	-	TMP-TENI
SHD2_k127_7560602_115	935557.ATYB01000014_gene4277	7.081e-75	258.0	COG0325@1|root,COG0325@2|Bacteria,1MWN7@1224|Proteobacteria,2TR5Z@28211|Alphaproteobacteria,4B7MG@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis	MA20_24865	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
SHD2_k127_7560602_144	1105367.CG50_15985	2.828e-55	198.0	COG3786@1|root,COG3786@2|Bacteria,1RH22@1224|Proteobacteria,2U992@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
SHD2_k127_7560602_202	331869.BAL199_10987	1.667e-19	99.0	2E38X@1|root,32Y8M@2|Bacteria,1N7Y0@1224|Proteobacteria,2UGIT@28211|Alphaproteobacteria,4BR46@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_7560602_77	414684.RC1_2933	5.92e-100	337.0	COG0807@1|root,COG0807@2|Bacteria,1MWZR@1224|Proteobacteria,2TR82@28211|Alphaproteobacteria,2JQNP@204441|Rhodospirillales	204441|Rhodospirillales	H	Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate	ribA	-	3.5.4.25	ko:K01497	ko00740,ko00790,ko01100,ko01110,ko02024,map00740,map00790,map01100,map01110,map02024	M00125	R00425	RC00293,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydro2
SHD2_k127_7560602_86	1402135.SUH3_10955	8.629e-94	312.0	COG0745@1|root,COG0745@2|Bacteria,1MU3A@1224|Proteobacteria,2TR97@28211|Alphaproteobacteria,3ZWA6@60136|Sulfitobacter	28211|Alphaproteobacteria	T	Transcriptional regulatory protein, C terminal	mtrA	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
SHD2_k127_7560602_212	1247963.JPHU01000002_gene2581	4.858e-13	81.0	COG2982@1|root,COG2982@2|Bacteria,1N6H2@1224|Proteobacteria,2TXVQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Protein involved in outer membrane biogenesis	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_7560602_26	1122929.KB908218_gene1459	3.411e-176	574.0	COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,2TQQ8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	penicillin-binding protein	pbpC	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
SHD2_k127_7560602_130	402881.Plav_0010	1.231e-64	230.0	COG1451@1|root,COG1451@2|Bacteria,1MXZU@1224|Proteobacteria,2U1JG@28211|Alphaproteobacteria,1JP1Q@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function DUF45	MA20_23375	-	-	ko:K07043	-	-	-	-	ko00000	-	-	-	DUF45
SHD2_k127_7560602_141	450851.PHZ_c0406	3.64e-58	207.0	COG3565@1|root,COG3565@2|Bacteria,1RD7C@1224|Proteobacteria,2U78G@28211|Alphaproteobacteria,2KJCW@204458|Caulobacterales	204458|Caulobacterales	S	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	ko:K06991	-	-	-	-	ko00000	-	-	-	Glyoxalase
SHD2_k127_7560602_181	1379701.JPJC01000093_gene2940	2.968e-31	130.0	COG1495@1|root,COG1495@2|Bacteria,1N89I@1224|Proteobacteria,2UF49@28211|Alphaproteobacteria,2K59V@204457|Sphingomonadales	204457|Sphingomonadales	O	Disulfide bond formation protein	-	-	-	-	-	-	-	-	-	-	-	-	DsbB
SHD2_k127_7560602_137	349163.Acry_0153	5.491e-60	213.0	COG2941@1|root,COG2941@2|Bacteria,1RAK4@1224|Proteobacteria,2U85I@28211|Alphaproteobacteria,2JSA9@204441|Rhodospirillales	204441|Rhodospirillales	H	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol	coq7	-	-	ko:K06134	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00128	R04984,R08775	RC01254	ko00000,ko00001,ko00002,ko01000	-	-	-	COQ7
SHD2_k127_7560602_150	414684.RC1_0257	3.108e-46	176.0	COG0454@1|root,COG0456@2|Bacteria,1RDNX@1224|Proteobacteria,2U70R@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
SHD2_k127_7560602_79	670307.HYPDE_40843	8.439e-97	320.0	COG1403@1|root,COG1403@2|Bacteria,1MWEQ@1224|Proteobacteria,2TR3M@28211|Alphaproteobacteria,3N6JY@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	HNH endonuclease	MA20_20605	-	-	-	-	-	-	-	-	-	-	-	HNH,HNH_5
SHD2_k127_7560602_117	402881.Plav_1632	3.175e-74	257.0	COG0400@1|root,COG0400@2|Bacteria,1RA02@1224|Proteobacteria,2TTWP@28211|Alphaproteobacteria,1JP1I@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Phospholipase/Carboxylesterase	-	-	-	ko:K06999	-	-	-	-	ko00000	-	-	-	Abhydrolase_2
SHD2_k127_7560602_195	498848.TaqDRAFT_3572	1.712e-23	112.0	COG1247@1|root,COG1247@2|Bacteria,1WJKN@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	M	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,FR47
SHD2_k127_7560602_76	1244869.H261_13549	3.372e-100	333.0	COG0008@1|root,COG0008@2|Bacteria,1MUN7@1224|Proteobacteria,2TR2V@28211|Alphaproteobacteria,2JPHU@204441|Rhodospirillales	204441|Rhodospirillales	J	Belongs to the class-I aminoacyl-tRNA synthetase family	gluQ	-	-	ko:K01894	-	-	-	-	ko00000,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c
SHD2_k127_7560602_207	1280952.HJA_08844	4.009e-15	84.0	COG4319@1|root,COG4319@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,DUF4440,SnoaL_2,SnoaL_3,YkuD
SHD2_k127_7560602_6	1380391.JIAS01000003_gene1762	3.772e-279	871.0	COG2185@1|root,COG2185@2|Bacteria,1QU3N@1224|Proteobacteria,2TVY1@28211|Alphaproteobacteria,2JPZR@204441|Rhodospirillales	204441|Rhodospirillales	I	Methylmalonyl-CoA mutase	-	-	5.4.99.63	ko:K14447	ko00630,ko01120,ko01200,map00630,map01120,map01200	M00373	R09292	RC02835	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,MM_CoA_mutase
SHD2_k127_7560602_205	398720.MED217_12324	1.14e-17	94.0	COG3358@1|root,COG3358@2|Bacteria,4NNWJ@976|Bacteroidetes,1I20T@117743|Flavobacteriia,2XJWG@283735|Leeuwenhoekiella	976|Bacteroidetes	S	Protein of unknown function (DUF1684)	-	-	-	ko:K09164	-	-	-	-	ko00000	-	-	-	DUF1684
SHD2_k127_7560602_104	1205680.CAKO01000010_gene3741	3.295e-82	275.0	COG0346@1|root,COG0346@2|Bacteria,1N2KZ@1224|Proteobacteria,2UBQR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
SHD2_k127_7560602_186	366602.Caul_0877	2.346e-28	119.0	2E4P4@1|root,32ZHW@2|Bacteria,1N9SK@1224|Proteobacteria,2UFQ7@28211|Alphaproteobacteria,2KHD4@204458|Caulobacterales	204458|Caulobacterales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_7560602_9	648757.Rvan_2964	5.703e-248	769.0	COG0604@1|root,COG0604@2|Bacteria,1MXIK@1224|Proteobacteria,2TQPR@28211|Alphaproteobacteria,3N7S6@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	reductase	ccrA	-	1.1.1.1,1.3.1.85	ko:K00001,ko:K14446	ko00010,ko00071,ko00350,ko00625,ko00626,ko00630,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00010,map00071,map00350,map00625,map00626,map00630,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220	M00373	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310,R09291	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273,RC02481	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
SHD2_k127_7560602_230	269797.Mbar_A2055	0.0003197	48.0	COG5513@1|root,arCOG03544@2157|Archaea,2Y0YF@28890|Euryarchaeota,2N9ZK@224756|Methanomicrobia	224756|Methanomicrobia	S	Chagasin family peptidase inhibitor I42	-	-	-	ko:K14475	ko05143,map05143	-	-	-	ko00000,ko00001	-	-	-	Inhibitor_I42
SHD2_k127_7560602_11	402881.Plav_1613	1.508e-232	731.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TR78@28211|Alphaproteobacteria,1JPSR@119043|Rhodobiaceae	28211|Alphaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	mcd	-	1.3.8.12	ko:K14448	ko00630,ko01120,ko01200,map00630,map01120,map01200	M00373	R09293	RC02483	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
SHD2_k127_7560602_192	1333998.M2A_0231	1.427e-25	112.0	COG0140@1|root,COG0140@2|Bacteria,1MZEE@1224|Proteobacteria,2UBU3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Phosphoribosyl-ATP	hisE	-	3.6.1.31	ko:K01523	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-PH
SHD2_k127_7560602_166	1333998.M2A_0306	1.58e-39	150.0	COG1396@1|root,COG1396@2|Bacteria,1RDBW@1224|Proteobacteria,2U7CY@28211|Alphaproteobacteria,4BQJY@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	K	Helix-turn-helix XRE-family like proteins	QU41_21520	-	-	-	-	-	-	-	-	-	-	-	HTH_3
SHD2_k127_7560602_55	402881.Plav_3621	1.815e-124	417.0	COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,2TQRC@28211|Alphaproteobacteria,1JNAQ@119043|Rhodobiaceae	28211|Alphaproteobacteria	M	Transfers the fatty acyl group on membrane lipoproteins	lnt	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
SHD2_k127_7560602_100	402881.Plav_3620	1.075e-84	291.0	COG1253@1|root,COG1253@2|Bacteria,1MV3P@1224|Proteobacteria,2TVFA@28211|Alphaproteobacteria,1JNC1@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Transporter associated domain	tlyC	-	-	ko:K06189	-	-	-	-	ko00000,ko02000	9.A.40.1.2	-	-	CBS,CorC_HlyC
SHD2_k127_7560602_179	1449049.JONW01000006_gene2661	3.722e-32	130.0	COG0319@1|root,COG0319@2|Bacteria,1MZ67@1224|Proteobacteria,2UBXV@28211|Alphaproteobacteria,2KGPK@204458|Caulobacterales	204458|Caulobacterales	J	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA	ybeY	-	-	ko:K07042	-	-	-	-	ko00000,ko03009	-	-	-	UPF0054
SHD2_k127_7560602_69	1121106.JQKB01000001_gene3201	1.36e-105	352.0	COG1702@1|root,COG1702@2|Bacteria,1MVDV@1224|Proteobacteria,2TRV3@28211|Alphaproteobacteria,2JPRI@204441|Rhodospirillales	204441|Rhodospirillales	T	COG1702 Phosphate starvation-inducible protein PhoH	ybeZ	-	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
SHD2_k127_7560602_21	1120919.AUBI01000008_gene380	9.43e-188	595.0	COG0621@1|root,COG0621@2|Bacteria,1MURS@1224|Proteobacteria,2TQN6@28211|Alphaproteobacteria,2JP83@204441|Rhodospirillales	204441|Rhodospirillales	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
SHD2_k127_7560602_109	402881.Plav_3616	1.218e-78	273.0	COG0204@1|root,COG0204@2|Bacteria,1N2DG@1224|Proteobacteria,2TT8Q@28211|Alphaproteobacteria,1JNWR@119043|Rhodobiaceae	28211|Alphaproteobacteria	I	Phosphate acyltransferases	plsC	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
SHD2_k127_7560602_134	1161401.ASJA01000003_gene2761	3.33e-61	215.0	COG0735@1|root,COG0735@2|Bacteria,1RDWJ@1224|Proteobacteria,2U6ZS@28211|Alphaproteobacteria,43XNN@69657|Hyphomonadaceae	28211|Alphaproteobacteria	K	Belongs to the Fur family	fur	-	-	ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
SHD2_k127_7560602_180	588932.JHOF01000005_gene2107	2.268e-31	128.0	COG0454@1|root,COG0456@2|Bacteria,1RIE6@1224|Proteobacteria,2UF5C@28211|Alphaproteobacteria,2KH9N@204458|Caulobacterales	204458|Caulobacterales	K	This enzyme acetylates the N-terminal alanine of ribosomal protein S18	-	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
SHD2_k127_7560602_169	450851.PHZ_c3457	4.709e-38	150.0	COG1214@1|root,COG1214@2|Bacteria,1MXPH@1224|Proteobacteria,2TTM2@28211|Alphaproteobacteria,2KGSU@204458|Caulobacterales	204458|Caulobacterales	O	PFAM peptidase M22 glycoprotease	-	-	-	ko:K14742	-	-	-	-	ko00000,ko03016	-	-	-	Peptidase_M22
SHD2_k127_7560602_128	1205680.CAKO01000038_gene1931	3.716e-66	234.0	COG0778@1|root,COG0778@2|Bacteria,1R9VX@1224|Proteobacteria,2U5B0@28211|Alphaproteobacteria,2JRTH@204441|Rhodospirillales	204441|Rhodospirillales	C	NADH dehydrogenase NAD(P)H nitroreductase	rutE	-	-	ko:K09019	ko00240,ko01100,map00240,map01100	-	R09289	RC00087	ko00000,ko00001,ko01000	-	-	-	Nitroreductase
SHD2_k127_7560602_111	1333998.M2A_0296	2.882e-77	263.0	COG0694@1|root,COG0694@2|Bacteria,1MVQ1@1224|Proteobacteria,2TUD1@28211|Alphaproteobacteria,4BQ59@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	O	PFAM Scaffold protein Nfu NifU N terminal	nifU	-	-	-	-	-	-	-	-	-	-	-	Nfu_N,NifU
SHD2_k127_7560602_215	1333998.M2A_0146	1.051e-11	67.0	COG5508@1|root,COG5508@2|Bacteria,1QS3B@1224|Proteobacteria,2VAW7@28211|Alphaproteobacteria,4BSYQ@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1674)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1674
SHD2_k127_7560602_65	1082932.ATCR1_10738	9.192e-113	374.0	COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,2TS3N@28211|Alphaproteobacteria,4B6YF@82115|Rhizobiaceae	28211|Alphaproteobacteria	O	Belongs to the peptidase M48B family	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
SHD2_k127_7560602_61	1333998.M2A_0149	4.955e-119	398.0	COG0144@1|root,COG0144@2|Bacteria,1MWPE@1224|Proteobacteria,2TSIA@28211|Alphaproteobacteria,4BPKA@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family	rsmB	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,NusB
SHD2_k127_7560602_149	1282876.BAOK01000001_gene1475	4.837e-48	195.0	COG0840@1|root,COG0840@2|Bacteria,1QZZ6@1224|Proteobacteria,2TYH8@28211|Alphaproteobacteria,4BQZE@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	NT	transmembrane signaling receptor activity	-	-	-	-	-	-	-	-	-	-	-	-	Apolipoprotein
SHD2_k127_7560602_118	1333998.M2A_0253	1.81e-73	254.0	COG4094@1|root,COG4094@2|Bacteria,1RDV6@1224|Proteobacteria,2VA1X@28211|Alphaproteobacteria,4BSXM@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	NnrU protein	-	-	-	-	-	-	-	-	-	-	-	-	NnrU
SHD2_k127_7560602_175	69395.JQLZ01000002_gene1156	5.23e-33	138.0	COG0454@1|root,COG0456@2|Bacteria,1N8AT@1224|Proteobacteria,2VERS@28211|Alphaproteobacteria,2KJ30@204458|Caulobacterales	204458|Caulobacterales	K	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
SHD2_k127_7560602_214	1123503.KB908056_gene1330	2.113e-12	72.0	COG2198@1|root,COG2198@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K07647	ko02020,map02020	M00455	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	Hpt
SHD2_k127_7560602_38	573065.Astex_2336	6.651e-154	492.0	COG0492@1|root,COG0492@2|Bacteria,1MW14@1224|Proteobacteria,2TSKU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	ferredoxin--NADP reductase	MA20_08170	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_3
SHD2_k127_7560602_167	331869.BAL199_12021	1.632e-39	149.0	COG0633@1|root,COG0633@2|Bacteria,1N261@1224|Proteobacteria,2UC7B@28211|Alphaproteobacteria,4BQVH@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	2Fe-2S iron-sulfur cluster binding domain	fdx	-	-	ko:K04755	-	-	-	-	ko00000	-	-	-	Fer2
SHD2_k127_7560602_108	402881.Plav_2526	1.546e-79	270.0	COG0500@1|root,COG2226@2|Bacteria,1RANW@1224|Proteobacteria,2U66N@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23
SHD2_k127_7560602_14	1382303.JPOM01000001_gene2351	1.434e-209	672.0	COG4805@1|root,COG4805@2|Bacteria,1MUBX@1224|Proteobacteria,2TSUQ@28211|Alphaproteobacteria,2KFHK@204458|Caulobacterales	204458|Caulobacterales	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
SHD2_k127_7560602_113	316057.RPD_2668	5.082e-77	265.0	COG0625@1|root,COG0625@2|Bacteria,1MXHH@1224|Proteobacteria,2TVGY@28211|Alphaproteobacteria,3JZUB@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Glutathione S-transferase, C-terminal domain	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_3,GST_N
SHD2_k127_7560602_162	670487.Ocepr_2228	1.256e-40	158.0	COG0500@1|root,COG1266@1|root,COG1266@2|Bacteria,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Abi,Methyltransf_11,Methyltransf_23,Methyltransf_25
SHD2_k127_7560602_94	1122604.JONR01000006_gene2731	1.3e-86	294.0	COG5285@1|root,COG5285@2|Bacteria,1QRDD@1224|Proteobacteria,1RQ6U@1236|Gammaproteobacteria,1X93S@135614|Xanthomonadales	135614|Xanthomonadales	Q	Phytanoyl-CoA dioxygenase (PhyH)	-	-	-	-	-	-	-	-	-	-	-	-	PhyH
SHD2_k127_7560602_16	450851.PHZ_c0904	4.911e-203	640.0	COG3825@1|root,COG3825@2|Bacteria,1MUAJ@1224|Proteobacteria,2TS5P@28211|Alphaproteobacteria,2KG62@204458|Caulobacterales	204458|Caulobacterales	S	VWA domain containing CoxE-like protein	-	-	-	ko:K09989	-	-	-	-	ko00000	-	-	-	VWA_CoxE
SHD2_k127_7560602_36	450851.PHZ_c1379	4.632e-155	492.0	COG0714@1|root,COG0714@2|Bacteria,1MV5I@1224|Proteobacteria,2TRI8@28211|Alphaproteobacteria,2KFG3@204458|Caulobacterales	204458|Caulobacterales	S	AAA domain (dynein-related subfamily)	-	-	-	-	-	-	-	-	-	-	-	-	AAA,AAA_5
SHD2_k127_7560602_98	402881.Plav_3594	5.898e-85	289.0	COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,2TQU6@28211|Alphaproteobacteria,1JN2S@119043|Rhodobiaceae	28211|Alphaproteobacteria	O	Magnesium chelatase, subunit ChlI C-terminal	comM	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
SHD2_k127_7560602_194	351016.RAZWK3B_09706	7.932e-24	107.0	COG0582@1|root,COG0582@2|Bacteria,1RD46@1224|Proteobacteria,2U6YQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG0582 Integrase	-	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_integrase
SHD2_k127_7560602_4	663610.JQKO01000002_gene1239	1.768e-302	936.0	COG0003@1|root,COG0003@2|Bacteria,1MUTX@1224|Proteobacteria,2TUA8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Anion-transporting ATPase	arsA	-	3.6.3.16	ko:K01551	-	-	-	-	ko00000,ko01000,ko02000	3.A.19.1,3.A.21.1,3.A.4.1	-	-	ArsA_ATPase,CbiA
SHD2_k127_7560602_20	366602.Caul_1953	7.484e-188	593.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TQQ7@28211|Alphaproteobacteria,2KG3B@204458|Caulobacterales	28211|Alphaproteobacteria	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
SHD2_k127_7560602_126	1547437.LL06_17665	2.285e-67	233.0	COG0394@1|root,COG0394@2|Bacteria,1MWYQ@1224|Proteobacteria,2TU1U@28211|Alphaproteobacteria,43J6K@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	T	Belongs to the low molecular weight phosphotyrosine protein phosphatase family	-	-	1.20.4.1	ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	HTH_20,LMWPc
SHD2_k127_7560602_67	502025.Hoch_2835	8.028e-111	364.0	COG0346@1|root,COG0394@1|root,COG0346@2|Bacteria,COG0394@2|Bacteria,1MWYQ@1224|Proteobacteria,42SQK@68525|delta/epsilon subdivisions,2WPK1@28221|Deltaproteobacteria,2Z32Z@29|Myxococcales	28221|Deltaproteobacteria	T	PFAM Protein-tyrosine phosphatase, low molecular weight	-	-	1.20.4.1	ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
SHD2_k127_7560602_23	1122962.AULH01000005_gene2783	2.593e-180	569.0	COG0798@1|root,COG0798@2|Bacteria,1MUXY@1224|Proteobacteria,2TSVJ@28211|Alphaproteobacteria,36X5W@31993|Methylocystaceae	28211|Alphaproteobacteria	P	Sodium Bile acid symporter family	-	-	-	ko:K03325	-	-	-	-	ko00000,ko02000	2.A.59	-	-	SBF
SHD2_k127_7560602_172	1207063.P24_14194	2.959e-35	138.0	COG0640@1|root,COG0640@2|Bacteria,1N7I7@1224|Proteobacteria,2UF6D@28211|Alphaproteobacteria,2JXMZ@204441|Rhodospirillales	204441|Rhodospirillales	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5
SHD2_k127_7560602_225	1125973.JNLC01000001_gene39	1.989e-06	50.0	COG4645@1|root,COG4645@2|Bacteria,1PI9Q@1224|Proteobacteria,2U1C7@28211|Alphaproteobacteria,3JQY7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	OpgC protein	MA20_22360	-	-	-	-	-	-	-	-	-	-	-	OpgC_C
SHD2_k127_7560602_228	1502851.FG93_03877	0.0001109	46.0	COG4645@1|root,COG4645@2|Bacteria,1PI9Q@1224|Proteobacteria,2U1C7@28211|Alphaproteobacteria,3JQY7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	OpgC protein	MA20_22360	-	-	-	-	-	-	-	-	-	-	-	OpgC_C
SHD2_k127_7560602_229	1188256.BASI01000005_gene1868	0.0001944	45.0	COG4645@1|root,COG4645@2|Bacteria,1PI9Q@1224|Proteobacteria,2U1C7@28211|Alphaproteobacteria,3FEFQ@34008|Rhodovulum	28211|Alphaproteobacteria	S	OpgC protein	-	-	-	-	-	-	-	-	-	-	-	-	OpgC_C
SHD2_k127_7560602_40	1234364.AMSF01000003_gene2430	6.085e-150	483.0	COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,1RPPQ@1236|Gammaproteobacteria,1X493@135614|Xanthomonadales	135614|Xanthomonadales	P	cytochrome c peroxidase	-	-	1.11.1.5	ko:K00428	-	-	-	-	ko00000,ko01000	-	-	-	CCP_MauG,Cytochrom_C
SHD2_k127_7560602_32	1205680.CAKO01000002_gene3078	7.152e-164	523.0	COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,1MURA@1224|Proteobacteria,2TR1F@28211|Alphaproteobacteria,2JPND@204441|Rhodospirillales	204441|Rhodospirillales	P	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
SHD2_k127_7560602_155	1382303.JPOM01000001_gene432	1.815e-44	164.0	COG0599@1|root,COG0599@2|Bacteria,1MZ80@1224|Proteobacteria,2UDE8@28211|Alphaproteobacteria,2KGYX@204458|Caulobacterales	204458|Caulobacterales	O	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
SHD2_k127_7560602_82	1333998.M2A_1145	4.814e-95	318.0	COG0730@1|root,COG0730@2|Bacteria,1MVBS@1224|Proteobacteria,2TQW0@28211|Alphaproteobacteria,4BSU3@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
SHD2_k127_7589968_1	68223.JNZY01000062_gene1107	4.048e-72	255.0	COG0574@1|root,COG0574@2|Bacteria,2IJCV@201174|Actinobacteria	201174|Actinobacteria	G	Pyruvate phosphate dikinase, PEP/pyruvate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PPDK_N
SHD2_k127_7589968_0	68223.JNZY01000062_gene1108	5.344e-123	414.0	COG3848@1|root,COG3848@2|Bacteria,2IE61@201174|Actinobacteria	201174|Actinobacteria	T	PEP-utilising enzyme, mobile domain	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers
SHD2_k127_7589968_3	1041159.AZUW01000054_gene5606	1.769e-13	76.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,4B9BA@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc
SHD2_k127_7589968_2	1123296.JQKE01000067_gene23	1.222e-34	139.0	COG0790@1|root,COG0790@2|Bacteria,1MWPA@1224|Proteobacteria,2VM3A@28216|Betaproteobacteria,2KPMA@206351|Neisseriales	206351|Neisseriales	KLT	Psort location Extracellular, score	-	-	-	-	-	-	-	-	-	-	-	-	Sel1
SHD2_k127_7600676_2	1333998.M2A_2116	4.572e-129	420.0	COG2030@1|root,COG2030@2|Bacteria,1MUR2@1224|Proteobacteria,2TUM7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	dehydratase	MA20_35600	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydrat_N,MaoC_dehydratas
SHD2_k127_7600676_8	1244869.H261_04520	6.34e-54	203.0	COG0457@1|root,COG4976@1|root,COG0457@2|Bacteria,COG4976@2|Bacteria,1RAIT@1224|Proteobacteria,2U5NY@28211|Alphaproteobacteria,2JS93@204441|Rhodospirillales	204441|Rhodospirillales	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23,TPR_16,TPR_2,TPR_8
SHD2_k127_7600676_4	331869.BAL199_18238	5.261e-73	251.0	COG4977@1|root,COG4977@2|Bacteria,1QUTN@1224|Proteobacteria,2TW75@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	DJ-1/PfpI family	-	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI
SHD2_k127_7600676_11	1218076.BAYB01000060_gene6287	0.0003189	51.0	COG1309@1|root,COG1309@2|Bacteria,1RC1X@1224|Proteobacteria,2VYH2@28216|Betaproteobacteria,1K12H@119060|Burkholderiaceae	28216|Betaproteobacteria	K	WHG domain	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N,WHG
SHD2_k127_7600676_3	402881.Plav_0477	5.169e-79	274.0	COG0824@1|root,COG0824@2|Bacteria,1R66P@1224|Proteobacteria,2U3KF@28211|Alphaproteobacteria,1JPG8@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Thioesterase	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT_2
SHD2_k127_7600676_6	1333998.M2A_2105	3.497e-65	233.0	COG2267@1|root,COG2267@2|Bacteria,1N8UK@1224|Proteobacteria,2U35V@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
SHD2_k127_7600676_1	59538.XP_005974403.1	3.769e-214	676.0	COG0318@1|root,KOG1176@2759|Eukaryota,3AIZB@33154|Opisthokonta,3BXNQ@33208|Metazoa,3DFMP@33213|Bilateria,48SPA@7711|Chordata,49P71@7742|Vertebrata,3JP3T@40674|Mammalia,4J1NF@91561|Cetartiodactyla	33208|Metazoa	I	4-coumarate--CoA	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
SHD2_k127_7600676_5	1380394.JADL01000003_gene4785	5.92e-66	233.0	COG3703@1|root,COG3703@2|Bacteria,1QA7D@1224|Proteobacteria,2U84Q@28211|Alphaproteobacteria,2JZR9@204441|Rhodospirillales	204441|Rhodospirillales	P	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides	-	-	-	ko:K07232	-	-	-	-	ko00000	-	-	-	ChaC
SHD2_k127_7600676_7	450851.PHZ_c2720	5.999e-63	219.0	COG2030@1|root,COG2030@2|Bacteria,1RHPH@1224|Proteobacteria,2U9GG@28211|Alphaproteobacteria,2KGB0@204458|Caulobacterales	204458|Caulobacterales	I	PFAM MaoC domain protein dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
SHD2_k127_7600676_9	1280948.HY36_16365	3.547e-28	120.0	COG2119@1|root,COG2119@2|Bacteria,1PP1X@1224|Proteobacteria,2V9AT@28211|Alphaproteobacteria,440DU@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	Uncharacterized protein family UPF0016	-	-	-	-	-	-	-	-	-	-	-	-	UPF0016
SHD2_k127_7600676_0	1411123.JQNH01000001_gene1082	0.0	1143.0	COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,2TSZ9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	MA20_17010	-	1.2.4.1	ko:K00163	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
SHD2_k127_7724507_2	666684.AfiDRAFT_3808	8.728e-119	383.0	COG2223@1|root,COG2223@2|Bacteria,1MWC7@1224|Proteobacteria,2TWNV@28211|Alphaproteobacteria,3K6Y1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SHD2_k127_7724507_5	666684.AfiDRAFT_3809	2.613e-08	56.0	2AHFA@1|root,317SJ@2|Bacteria,1NKK0@1224|Proteobacteria,2UKVZ@28211|Alphaproteobacteria,3K1VZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_7724507_4	398525.KB900701_gene5870	1.774e-09	59.0	28I3D@1|root,2Z876@2|Bacteria,1P0DR@1224|Proteobacteria,2TTG2@28211|Alphaproteobacteria,3JUSV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	PilZ domain	MA20_31715	-	-	-	-	-	-	-	-	-	-	-	PilZ
SHD2_k127_7724507_0	323097.Nham_1626	1.693e-198	620.0	COG5433@1|root,COG5433@2|Bacteria,1MY25@1224|Proteobacteria,2U0Y8@28211|Alphaproteobacteria,3JV7B@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Transposase DDE domain group 1	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
SHD2_k127_7724507_3	420324.KI911947_gene5647	2.126e-43	160.0	COG2963@1|root,COG2963@2|Bacteria,1RGZ5@1224|Proteobacteria,2UAIS@28211|Alphaproteobacteria,1JVU8@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_1
SHD2_k127_7724507_1	420324.KI911947_gene5648	3.913e-160	509.0	COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria,1JTSW@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	PFAM Integrase catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve,rve_3
SHD2_k127_7724507_6	114615.BRADO5701	4.367e-06	48.0	COG3847@1|root,COG3847@2|Bacteria,1NGVU@1224|Proteobacteria,2UJE8@28211|Alphaproteobacteria,3K1BG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	U	Flp/Fap pilin component	pilA2	-	-	ko:K02651	ko04112,map04112	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	Flp_Fap
SHD2_k127_7739950_2	1122244.AUGF01000070_gene953	5.676e-23	98.0	2DPM9@1|root,332MQ@2|Bacteria,1NAPW@1224|Proteobacteria,1SDC6@1236|Gammaproteobacteria,3NRXM@468|Moraxellaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_7739950_4	1150469.RSPPHO_03241	2.812e-05	46.0	2DU3E@1|root,33NT0@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_7739950_0	1169152.AXVD01000041_gene266	2.981e-136	444.0	COG1680@1|root,COG1680@2|Bacteria,2GJJB@201174|Actinobacteria,4FXBC@85025|Nocardiaceae	201174|Actinobacteria	V	COG1680 Beta-lactamase class C and other penicillin binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
SHD2_k127_7739950_3	1007103.AFHW01000119_gene1269	1.305e-08	58.0	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_11,TetR_N
SHD2_k127_7739950_1	223192.XP_007915067.1	1.625e-52	193.0	COG4122@1|root,2RZAN@2759|Eukaryota,3A0IW@33154|Opisthokonta,3P243@4751|Fungi,3QSBB@4890|Ascomycota,217DT@147550|Sordariomycetes	4751|Fungi	H	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_24,Methyltransf_3
SHD2_k127_7782023_6	472175.EL18_01604	4.34e-41	152.0	COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,2TQQ1@28211|Alphaproteobacteria,43H01@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e
SHD2_k127_7782023_2	402881.Plav_1104	1.099e-161	522.0	COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,2TRCI@28211|Alphaproteobacteria,1JNHX@119043|Rhodobiaceae	28211|Alphaproteobacteria	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX1	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
SHD2_k127_7782023_0	402881.Plav_1103	5.216e-238	747.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1MU9U@1224|Proteobacteria,2TRAU@28211|Alphaproteobacteria,1JNPB@119043|Rhodobiaceae	28211|Alphaproteobacteria	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	nadE	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008795,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016874,GO:0016879,GO:0016880,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.1.5,6.3.5.1	ko:K01916,ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00189,R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
SHD2_k127_7782023_5	1247963.JPHU01000001_gene2034	1.04e-57	213.0	COG0673@1|root,COG0673@2|Bacteria,1MV7C@1224|Proteobacteria,2U17I@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
SHD2_k127_7782023_3	1333998.M2A_2342	1.458e-138	448.0	COG2130@1|root,COG2130@2|Bacteria,1MUC2@1224|Proteobacteria,2TQYM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	NADP-dependent oxidoreductase	-	-	-	ko:K07119	-	-	-	-	ko00000	-	-	-	ADH_N_2,ADH_zinc_N
SHD2_k127_7782023_1	1333998.M2A_2349	4.951e-228	715.0	COG3200@1|root,COG3200@2|Bacteria,1MUWF@1224|Proteobacteria,2TR0E@28211|Alphaproteobacteria,4BPG9@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	phospho-2-dehydro-3-deoxyheptonate aldolase	aroF	GO:0003674,GO:0003824,GO:0003849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009507,GO:0009536,GO:0009611,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019438,GO:0019752,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0050896,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.54	ko:K01626	ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_2
SHD2_k127_7782023_7	314345.SPV1_01592	1.734e-08	63.0	2B64P@1|root,31Z1K@2|Bacteria,1RGUR@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_7782023_4	1192034.CAP_5241	1.994e-89	304.0	COG2207@1|root,COG3449@1|root,COG2207@2|Bacteria,COG3449@2|Bacteria,1MWTF@1224|Proteobacteria,42RC6@68525|delta/epsilon subdivisions,2WN72@28221|Deltaproteobacteria,2Z2AN@29|Myxococcales	28221|Deltaproteobacteria	K	Bacterial transcription activator, effector binding domain	-	-	-	ko:K13652	-	-	-	-	ko00000,ko03000	-	-	-	GyrI-like,HTH_18
SHD2_k127_77935_0	319003.Bra1253DRAFT_02424	3.506e-238	741.0	COG3039@1|root,COG3039@2|Bacteria,1MVTU@1224|Proteobacteria,2TVIR@28211|Alphaproteobacteria,3JT6Q@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	hmm pf01609	-	-	-	ko:K07481	-	-	-	-	ko00000	-	-	-	DUF772
SHD2_k127_7807355_10	247634.GPB2148_2859	2.459e-49	185.0	COG1024@1|root,COG1024@2|Bacteria	2|Bacteria	I	Enoyl-CoA hydratase	echA8_2	-	-	-	-	-	-	-	-	-	-	-	ECH_1
SHD2_k127_7807355_12	383381.EH30_15630	1.142e-27	121.0	COG1359@1|root,COG1359@2|Bacteria,1N7AV@1224|Proteobacteria,2UIVG@28211|Alphaproteobacteria,2K7DX@204457|Sphingomonadales	204457|Sphingomonadales	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
SHD2_k127_7807355_11	1248760.ANFZ01000002_gene2997	3.834e-35	138.0	COG3631@1|root,COG3631@2|Bacteria,1RH7J@1224|Proteobacteria,2UB56@28211|Alphaproteobacteria,2K5TZ@204457|Sphingomonadales	204457|Sphingomonadales	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_4
SHD2_k127_7807355_4	1382303.JPOM01000001_gene43	1.219e-129	420.0	COG1024@1|root,COG1024@2|Bacteria,1PK10@1224|Proteobacteria,2TS4M@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
SHD2_k127_7807355_0	1220535.IMCC14465_09300	1.289e-214	677.0	COG4638@1|root,COG4638@2|Bacteria,1R4IX@1224|Proteobacteria,2U0IQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Rieske 2Fe-2S	-	-	-	-	-	-	-	-	-	-	-	-	Rieske,Ring_hydroxyl_A
SHD2_k127_7807355_3	1382303.JPOM01000001_gene42	2.046e-135	442.0	COG0508@1|root,COG0596@1|root,COG0508@2|Bacteria,COG0596@2|Bacteria,1NU1Q@1224|Proteobacteria,2U14D@28211|Alphaproteobacteria,2KKAF@204458|Caulobacterales	204458|Caulobacterales	C	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
SHD2_k127_7807355_8	1382303.JPOM01000001_gene41	6.175e-79	269.0	COG1309@1|root,COG1309@2|Bacteria,1N8UC@1224|Proteobacteria,2U3J4@28211|Alphaproteobacteria,2KJPF@204458|Caulobacterales	204458|Caulobacterales	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
SHD2_k127_7807355_1	1382303.JPOM01000001_gene40	5.17e-188	595.0	COG1960@1|root,COG1960@2|Bacteria,1MVJC@1224|Proteobacteria,2TQRA@28211|Alphaproteobacteria,2KFKM@204458|Caulobacterales	204458|Caulobacterales	C	Acyl-CoA dehydrogenase, middle domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
SHD2_k127_7807355_6	1382303.JPOM01000001_gene30	1.184e-118	386.0	COG1028@1|root,COG1028@2|Bacteria,1MW46@1224|Proteobacteria,2TUTU@28211|Alphaproteobacteria,2KH43@204458|Caulobacterales	204458|Caulobacterales	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
SHD2_k127_7807355_5	748247.AZKH_2298	2.46e-126	407.0	COG3828@1|root,COG3828@2|Bacteria,1QWCA@1224|Proteobacteria	1224|Proteobacteria	S	Protein conserved in bacteria	MA20_14010	-	-	ko:K09992	-	-	-	-	ko00000	-	-	-	ThuA
SHD2_k127_7807355_13	1397666.RS24_00832	5.975e-27	117.0	COG4308@1|root,COG4308@2|Bacteria,1NANW@1224|Proteobacteria,2VFXX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Limonene-1,2-epoxide hydrolase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	LEH
SHD2_k127_7807355_2	1382303.JPOM01000001_gene39	5.24e-186	589.0	COG2124@1|root,COG2124@2|Bacteria,1MY5H@1224|Proteobacteria,2TTRR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	cytochrome P450	-	-	-	-	-	-	-	-	-	-	-	-	p450
SHD2_k127_7807355_7	1382303.JPOM01000001_gene38	5.359e-105	347.0	COG1028@1|root,COG1028@2|Bacteria,1MUPX@1224|Proteobacteria,2TT6C@28211|Alphaproteobacteria,2KFEA@204458|Caulobacterales	28211|Alphaproteobacteria	IQ	short-chain dehydrogenase	-	-	1.1.1.51	ko:K05296	ko00140,ko00984,ko01100,ko01120,map00140,map00984,map01100,map01120	-	R01836,R01838,R02352,R02353,R03406,R03407,R09956,R09957	RC00127,RC00144	ko00000,ko00001,ko01000	-	-	-	adh_short_C2
SHD2_k127_7807355_9	1545915.JROG01000009_gene2664	2.324e-53	207.0	COG1629@1|root,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,2U3YD@28211|Alphaproteobacteria,2KEF9@204457|Sphingomonadales	204457|Sphingomonadales	P	TonB-dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
SHD2_k127_7862734_1	1380394.JADL01000003_gene4831	2.137e-80	271.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,2TU21@28211|Alphaproteobacteria,2JSY5@204441|Rhodospirillales	204441|Rhodospirillales	C	Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR,POR_N
SHD2_k127_7862734_0	1038860.AXAP01000037_gene3192	4.364e-173	549.0	COG1013@1|root,COG1013@2|Bacteria,1R5BF@1224|Proteobacteria,2TR4R@28211|Alphaproteobacteria,3JTAE@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	MA20_01040	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFO_beta_C,TPP_enzyme_C
SHD2_k127_7862734_2	414684.RC1_2019	1.639e-53	192.0	COG3751@1|root,COG3751@2|Bacteria,1R4BC@1224|Proteobacteria,2U2Q5@28211|Alphaproteobacteria,2JYT8@204441|Rhodospirillales	204441|Rhodospirillales	O	2OG-Fe(II) oxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	2OG-FeII_Oxy_3
SHD2_k127_7917077_2	402881.Plav_2786	4.564e-232	725.0	COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2TRA0@28211|Alphaproteobacteria,1JN9S@119043|Rhodobiaceae	28211|Alphaproteobacteria	I	Carboxyl transferase domain	mccB	-	6.4.1.4	ko:K01969	ko00280,ko01100,map00280,map01100	M00036	R04138	RC00367,RC00942	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
SHD2_k127_7917077_3	450851.PHZ_c3025	1.494e-227	722.0	COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,2TRC2@28211|Alphaproteobacteria,2KFW5@204458|Caulobacterales	204458|Caulobacterales	I	carboxylase	-	-	6.4.1.3,6.4.1.4	ko:K01965,ko:K01968	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00036,M00373,M00741	R01859,R04138	RC00097,RC00367,RC00609,RC00942	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
SHD2_k127_7917077_18	876269.ARWA01000001_gene2266	8.762e-45	167.0	COG5458@1|root,COG5458@2|Bacteria,1N054@1224|Proteobacteria,2UBY1@28211|Alphaproteobacteria,3NCM1@45404|Beijerinckiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1489)	MA20_36070	-	-	-	-	-	-	-	-	-	-	-	DUF1489
SHD2_k127_7917077_9	69279.BG36_23820	1.11e-91	309.0	COG0414@1|root,COG0414@2|Bacteria,1MV1S@1224|Proteobacteria,2TS2D@28211|Alphaproteobacteria,43IP8@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate	panC	GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_ligase
SHD2_k127_7917077_1	570952.ATVH01000016_gene2568	0.0	1159.0	COG0506@1|root,COG4230@1|root,COG0506@2|Bacteria,COG4230@2|Bacteria,1MV93@1224|Proteobacteria,2TQPT@28211|Alphaproteobacteria,2JPKY@204441|Rhodospirillales	204441|Rhodospirillales	CE	Oxidizes proline to glutamate for use as a carbon and nitrogen source	putA	-	1.2.1.88,1.5.5.2	ko:K13821	ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130	-	R00245,R00707,R00708,R01253,R04444,R04445,R05051	RC00080,RC00083,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000,ko03000	-	-	-	Aldedh,Pro_dh,Pro_dh-DNA_bdg
SHD2_k127_7917077_11	631454.N177_3642	1.809e-63	230.0	COG2304@1|root,COG2304@2|Bacteria,1RA4S@1224|Proteobacteria,2U5T8@28211|Alphaproteobacteria,1JNRF@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_7917077_12	1380394.JADL01000010_gene4241	1.932e-51	190.0	COG2214@1|root,COG2214@2|Bacteria,1PUS9@1224|Proteobacteria,2TT35@28211|Alphaproteobacteria,2JS9H@204441|Rhodospirillales	204441|Rhodospirillales	O	DnaJ molecular chaperone homology domain	-	-	-	-	-	-	-	-	-	-	-	-	DnaJ
SHD2_k127_7917077_10	426117.M446_2257	2.906e-81	291.0	COG1686@1|root,COG3087@1|root,COG1686@2|Bacteria,COG3087@2|Bacteria,1MUU7@1224|Proteobacteria,2TRCV@28211|Alphaproteobacteria,1JT0T@119045|Methylobacteriaceae	28211|Alphaproteobacteria	M	Belongs to the peptidase S11 family	dacA1	-	3.4.16.4	ko:K01286,ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	Peptidase_S11,SPOR
SHD2_k127_7917077_22	1121861.KB899915_gene1777	7.223e-15	80.0	COG5490@1|root,COG5490@2|Bacteria,1N3RI@1224|Proteobacteria,2UEFJ@28211|Alphaproteobacteria,2JTR0@204441|Rhodospirillales	204441|Rhodospirillales	S	Phasin protein	-	-	-	-	-	-	-	-	-	-	-	-	Phasin_2
SHD2_k127_7917077_13	1380391.JIAS01000012_gene4050	1.045e-49	179.0	COG2127@1|root,COG2127@2|Bacteria,1MZU8@1224|Proteobacteria,2U982@28211|Alphaproteobacteria,2JSWP@204441|Rhodospirillales	204441|Rhodospirillales	S	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation	clpS	-	-	ko:K06891	-	-	-	-	ko00000	-	-	-	ClpS
SHD2_k127_7917077_0	631454.N177_3647	0.0	1189.0	COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,2TQUZ@28211|Alphaproteobacteria,1JNFE@119043|Rhodobiaceae	28211|Alphaproteobacteria	O	C-terminal, D2-small domain, of ClpB protein	clpA	GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0043335,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564	-	ko:K03694	-	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
SHD2_k127_7917077_21	1173264.KI913949_gene1512	4.045e-23	106.0	COG2827@1|root,COG2827@2|Bacteria	2|Bacteria	L	Endonuclease containing a URI domain	-	-	-	ko:K07461	-	-	-	-	ko00000	-	-	-	GIY-YIG
SHD2_k127_7917077_17	1282876.BAOK01000001_gene1781	8.123e-46	169.0	2E474@1|root,32Z30@2|Bacteria,1NDQE@1224|Proteobacteria,2VFXZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_7917077_20	565655.ECBG_02645	1.644e-30	125.0	COG1162@1|root,COG1162@2|Bacteria,1W78G@1239|Firmicutes,4ICYS@91061|Bacilli,4B5PB@81852|Enterococcaceae	91061|Bacilli	S	RNHCP domain	-	-	-	-	-	-	-	-	-	-	-	-	RNHCP
SHD2_k127_7917077_19	1429916.X566_23145	3.389e-40	151.0	COG2329@1|root,COG2329@2|Bacteria,1N078@1224|Proteobacteria,2U99H@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Antibiotic biosynthesis monooxygenase	MA20_36975	-	-	-	-	-	-	-	-	-	-	-	ABM
SHD2_k127_7917077_14	402881.Plav_2801	3.467e-48	175.0	COG0537@1|root,COG0537@2|Bacteria,1RDCJ@1224|Proteobacteria,2U956@28211|Alphaproteobacteria,1JP3F@119043|Rhodobiaceae	28211|Alphaproteobacteria	FG	Scavenger mRNA decapping enzyme C-term binding	hit	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
SHD2_k127_7917077_5	1282876.BAOK01000001_gene1785	1.564e-141	474.0	COG3146@1|root,COG3146@2|Bacteria,1MU35@1224|Proteobacteria,2TS5I@28211|Alphaproteobacteria,4BPKZ@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Peptidogalycan biosysnthesis/recognition	MA20_36195	-	-	ko:K09919	-	-	-	-	ko00000	-	-	-	FemAB_like
SHD2_k127_7917077_15	1380391.JIAS01000012_gene4043	3.406e-46	177.0	COG0251@1|root,COG0251@2|Bacteria,1RHMZ@1224|Proteobacteria,2U9H4@28211|Alphaproteobacteria,2JSC3@204441|Rhodospirillales	204441|Rhodospirillales	J	translation initiation inhibitor, yjgF family	-	-	-	-	-	-	-	-	-	-	-	-	YjgF_endoribonc
SHD2_k127_7917077_7	402881.Plav_2804	8.012e-111	368.0	COG2957@1|root,COG2957@2|Bacteria,1MX65@1224|Proteobacteria,2U0RR@28211|Alphaproteobacteria,1JQ16@119043|Rhodobiaceae	28211|Alphaproteobacteria	E	Porphyromonas-type peptidyl-arginine deiminase	-	-	3.5.3.12	ko:K10536	ko00330,ko01100,map00330,map01100	-	R01416	RC00177	ko00000,ko00001,ko01000	-	-	-	PAD_porph
SHD2_k127_7917077_6	1122132.AQYH01000010_gene4257	4.376e-133	431.0	COG0388@1|root,COG0388@2|Bacteria,1MXG5@1224|Proteobacteria,2TVCS@28211|Alphaproteobacteria,4BDES@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Carbon-nitrogen hydrolase	aguB	-	3.5.1.53	ko:K12251	ko00330,ko01100,map00330,map01100	-	R01152	RC00096	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase
SHD2_k127_7917077_4	1122132.AQYH01000020_gene65	3.532e-156	503.0	COG0389@1|root,COG0389@2|Bacteria,1MUUH@1224|Proteobacteria,2TSJN@28211|Alphaproteobacteria,4B71P@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C
SHD2_k127_7917077_8	1207063.P24_09306	1.821e-104	349.0	COG1940@1|root,COG1940@2|Bacteria,1MU94@1224|Proteobacteria,2TRRU@28211|Alphaproteobacteria,2JQ4F@204441|Rhodospirillales	204441|Rhodospirillales	GK	ROK family	-	-	2.7.1.4	ko:K00847	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100	-	R00760,R00867,R03920	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	ROK
SHD2_k127_7917077_16	1282876.BAOK01000001_gene1793	4.446e-46	173.0	COG0647@1|root,COG0647@2|Bacteria,1RFSZ@1224|Proteobacteria,2U7SF@28211|Alphaproteobacteria,4BSRX@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	G	UMP catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_7944610_112	1123229.AUBC01000041_gene3825	3.371e-21	92.0	COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,2TQP8@28211|Alphaproteobacteria,3JRYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
SHD2_k127_7944610_120	717785.HYPMC_1707	4.14e-10	61.0	2DGHW@1|root,2ZW1T@2|Bacteria,1P867@1224|Proteobacteria,2UWAZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Evidence 5 No homology to any previously reported sequences	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_7944610_10	1007104.SUS17_569	5.931e-228	728.0	COG1629@1|root,COG4771@2|Bacteria,1MWB3@1224|Proteobacteria,2U1DE@28211|Alphaproteobacteria,2K2F9@204457|Sphingomonadales	204457|Sphingomonadales	P	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
SHD2_k127_7944610_125	452662.SJA_C1-18930	2.632e-05	53.0	2ARMY@1|root,31GYM@2|Bacteria,1QEMZ@1224|Proteobacteria,2UZ7P@28211|Alphaproteobacteria,2K8A4@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_7944610_73	1244869.H261_12301	7.148e-69	243.0	COG0566@1|root,COG0566@2|Bacteria,1MWCM@1224|Proteobacteria,2TUG7@28211|Alphaproteobacteria,2JQU3@204441|Rhodospirillales	204441|Rhodospirillales	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	rlmB	-	2.1.1.185	ko:K03218	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SpoU_methylase,SpoU_sub_bind
SHD2_k127_7944610_31	402881.Plav_0045	8.088e-122	404.0	COG0477@1|root,COG2814@2|Bacteria,1NU31@1224|Proteobacteria,2U5M0@28211|Alphaproteobacteria,1JQJA@119043|Rhodobiaceae	28211|Alphaproteobacteria	EGP	major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SHD2_k127_7944610_35	402881.Plav_0045	4.907e-116	388.0	COG0477@1|root,COG2814@2|Bacteria,1NU31@1224|Proteobacteria,2U5M0@28211|Alphaproteobacteria,1JQJA@119043|Rhodobiaceae	28211|Alphaproteobacteria	EGP	major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SHD2_k127_7944610_78	1429916.X566_15995	7.384e-60	219.0	COG1024@1|root,COG1024@2|Bacteria,1R3U7@1224|Proteobacteria,2TV9G@28211|Alphaproteobacteria,3JU2F@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
SHD2_k127_7944610_4	1282876.BAOK01000001_gene1872	4.108e-302	943.0	COG0188@1|root,COG0188@2|Bacteria,1MURI@1224|Proteobacteria,2TQRQ@28211|Alphaproteobacteria,4BP77@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	L	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule	parC	-	-	ko:K02621	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
SHD2_k127_7944610_65	1282876.BAOK01000001_gene1867	1.843e-78	269.0	COG1381@1|root,COG1381@2|Bacteria,1MVEJ@1224|Proteobacteria,2TTYW@28211|Alphaproteobacteria,4BQ6N@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	L	Involved in DNA repair and RecF pathway recombination	recO	-	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
SHD2_k127_7944610_34	402881.Plav_2875	4.135e-117	384.0	COG1159@1|root,COG1159@2|Bacteria,1MUKT@1224|Proteobacteria,2TSHM@28211|Alphaproteobacteria,1JNG0@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism	era	-	-	ko:K03595	-	-	-	-	ko00000,ko03009,ko03029	-	-	-	KH_2,MMR_HSR1
SHD2_k127_7944610_81	402881.Plav_2874	2.869e-57	209.0	COG0571@1|root,COG0571@2|Bacteria,1MUQ6@1224|Proteobacteria,2TTIA@28211|Alphaproteobacteria,1JNYP@119043|Rhodobiaceae	28211|Alphaproteobacteria	K	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	rnc	GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
SHD2_k127_7944610_57	1282876.BAOK01000001_gene1864	1.854e-87	297.0	COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,2TR9N@28211|Alphaproteobacteria,4BQ0P@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	U	Belongs to the peptidase S26 family	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
SHD2_k127_7944610_82	1192868.CAIU01000007_gene851	4.274e-56	199.0	COG0736@1|root,COG0736@2|Bacteria,1MZBF@1224|Proteobacteria,2U77S@28211|Alphaproteobacteria,43JYR@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	I	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein	acpS	-	2.7.8.7	ko:K00997	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
SHD2_k127_7944610_38	1090318.ATTI01000001_gene3341	1.117e-110	362.0	COG0854@1|root,COG0854@2|Bacteria,1MU9W@1224|Proteobacteria,2TTTF@28211|Alphaproteobacteria,2K0T4@204457|Sphingomonadales	204457|Sphingomonadales	H	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate	pdxJ	-	2.6.99.2	ko:K03474	ko00750,ko01100,map00750,map01100	M00124	R05838	RC01476	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxJ
SHD2_k127_7944610_60	1292034.OR37_00935	2.135e-81	278.0	2B47E@1|root,31WYM@2|Bacteria,1R5Q0@1224|Proteobacteria,2U37C@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_7944610_68	1479238.JQMZ01000001_gene1687	5.636e-76	259.0	COG0461@1|root,COG0461@2|Bacteria,1RIC5@1224|Proteobacteria,2TUX2@28211|Alphaproteobacteria,43XE1@69657|Hyphomonadaceae	28211|Alphaproteobacteria	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
SHD2_k127_7944610_6	1121033.AUCF01000001_gene2345	8.436e-257	813.0	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,2TQNY@28211|Alphaproteobacteria,2JPK1@204441|Rhodospirillales	204441|Rhodospirillales	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
SHD2_k127_7944610_103	107636.JQNK01000009_gene3246	4.601e-31	126.0	COG1758@1|root,COG1758@2|Bacteria,1N6TX@1224|Proteobacteria,2U9BQ@28211|Alphaproteobacteria,36YC5@31993|Methylocystaceae	28211|Alphaproteobacteria	K	RNA polymerase Rpb6	rpoZ	-	2.7.7.6	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
SHD2_k127_7944610_124	685778.AORL01000022_gene1418	2.547e-05	53.0	2ERK7@1|root,33J5Q@2|Bacteria,1NRZ4@1224|Proteobacteria,2UQEM@28211|Alphaproteobacteria,2K44W@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function (DUF1453)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1453
SHD2_k127_7944610_93	1150469.RSPPHO_01006	3.379e-48	177.0	COG0801@1|root,COG0801@2|Bacteria,1MZH8@1224|Proteobacteria,2U8D6@28211|Alphaproteobacteria,2JTNY@204441|Rhodospirillales	204441|Rhodospirillales	H	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)	folK	-	2.7.6.3	ko:K00950	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HPPK
SHD2_k127_7944610_58	1279038.KB907337_gene501	4.376e-87	291.0	COG1432@1|root,COG1432@2|Bacteria,1MUAE@1224|Proteobacteria,2TU5M@28211|Alphaproteobacteria,2JQQ5@204441|Rhodospirillales	204441|Rhodospirillales	S	NYN domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN
SHD2_k127_7944610_59	1101190.ARWB01000001_gene1267	9.334e-83	284.0	COG1573@1|root,COG1573@2|Bacteria,1MW91@1224|Proteobacteria,2TSUP@28211|Alphaproteobacteria,36Y9H@31993|Methylocystaceae	28211|Alphaproteobacteria	L	Uracil DNA glycosylase superfamily	ung	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
SHD2_k127_7944610_47	1282876.BAOK01000001_gene1850	4.466e-96	318.0	COG2041@1|root,COG2041@2|Bacteria,1MWZK@1224|Proteobacteria,2TTCH@28211|Alphaproteobacteria,4BRZR@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Oxidoreductase molybdopterin binding domain	yuiH	-	-	-	-	-	-	-	-	-	-	-	Oxidored_molyb
SHD2_k127_7944610_74	1282876.BAOK01000001_gene1849	2.348e-63	223.0	COG0691@1|root,COG0691@2|Bacteria,1RDFP@1224|Proteobacteria,2U71I@28211|Alphaproteobacteria,4BQB6@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	O	the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA	smpB	-	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
SHD2_k127_7944610_29	1336243.JAEA01000005_gene1402	9.149e-127	411.0	COG0329@1|root,COG0329@2|Bacteria,1MUCM@1224|Proteobacteria,2TR5W@28211|Alphaproteobacteria,1JQTP@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	GO:0003674,GO:0003824,GO:0006082,GO:0006090,GO:0008150,GO:0008152,GO:0008840,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044281,GO:0071704	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
SHD2_k127_7944610_115	1144307.PMI04_03566	8.614e-20	91.0	COG3813@1|root,COG3813@2|Bacteria,1N712@1224|Proteobacteria,2UFME@28211|Alphaproteobacteria,2K78J@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	ko:K09984	-	-	-	-	ko00000	-	-	-	DUF1272
SHD2_k127_7944610_28	402881.Plav_2861	1.593e-127	434.0	COG0741@1|root,COG0741@2|Bacteria,1MV3F@1224|Proteobacteria,2TRDB@28211|Alphaproteobacteria,1JNMD@119043|Rhodobiaceae	28211|Alphaproteobacteria	M	Transglycosylase SLT domain	slt	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	SLT
SHD2_k127_7944610_108	1282876.BAOK01000001_gene1817	2.361e-26	111.0	COG0790@1|root,COG0790@2|Bacteria,1N8SR@1224|Proteobacteria,2UFFQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	COG0790 FOG TPR repeat, SEL1 subfamily	MA20_36515	-	-	ko:K07126	-	-	-	-	ko00000	-	-	-	Sel1
SHD2_k127_7944610_11	1211115.ALIQ01000070_gene3824	1.707e-227	714.0	COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,2TRHX@28211|Alphaproteobacteria,3N9U6@45404|Beijerinckiaceae	28211|Alphaproteobacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
SHD2_k127_7944610_13	1333998.M2A_0683	2.275e-222	705.0	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,2TRFY@28211|Alphaproteobacteria,4BPTP@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
SHD2_k127_7944610_107	1280941.HY2_01305	2.587e-29	119.0	COG0721@1|root,COG0721@2|Bacteria,1MZQP@1224|Proteobacteria,2UBSZ@28211|Alphaproteobacteria,43Y62@69657|Hyphomonadaceae	28211|Alphaproteobacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	-	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Glu-tRNAGln
SHD2_k127_7944610_105	1007103.AFHW01000066_gene4067	2.201e-30	124.0	COG0346@1|root,COG0346@2|Bacteria,1VAEF@1239|Firmicutes,4HGTX@91061|Bacilli,26YD6@186822|Paenibacillaceae	91061|Bacilli	E	Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
SHD2_k127_7944610_91	1211115.ALIQ01000204_gene4798	4.816e-50	193.0	COG0816@1|root,COG0816@2|Bacteria,1RDHZ@1224|Proteobacteria,2U98Y@28211|Alphaproteobacteria,3NB3N@45404|Beijerinckiaceae	28211|Alphaproteobacteria	J	nuclease activity	ruvX	GO:0000966,GO:0000967,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	-	ko:K07447	-	-	-	-	ko00000,ko01000	-	-	-	RuvX
SHD2_k127_7944610_24	402881.Plav_2836	1.048e-143	464.0	COG0540@1|root,COG0540@2|Bacteria,1MWAB@1224|Proteobacteria,2TRHP@28211|Alphaproteobacteria,1JN0H@119043|Rhodobiaceae	28211|Alphaproteobacteria	F	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain	pyrB	GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
SHD2_k127_7944610_23	1282876.BAOK01000001_gene1808	4.995e-153	499.0	COG0044@1|root,COG0044@2|Bacteria,1MVXY@1224|Proteobacteria,2TSTM@28211|Alphaproteobacteria,4BPRA@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	F	Amidohydrolase family	pyrC	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
SHD2_k127_7944610_75	1333998.M2A_0690	6.676e-63	222.0	COG0344@1|root,COG0344@2|Bacteria,1RD4Z@1224|Proteobacteria,2U7BZ@28211|Alphaproteobacteria,4BQCC@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	I	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP	plsY	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
SHD2_k127_7944610_30	414684.RC1_1527	1.864e-122	403.0	COG0758@1|root,COG0758@2|Bacteria,1MVF6@1224|Proteobacteria,2TRQE@28211|Alphaproteobacteria,2JPC1@204441|Rhodospirillales	204441|Rhodospirillales	LU	Rossmann fold nucleotide-binding protein involved in DNA uptake	dprA	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
SHD2_k127_7944610_2	1449049.JONW01000011_gene2319	0.0	1091.0	COG0550@1|root,COG1754@1|root,COG0550@2|Bacteria,COG1754@2|Bacteria,1MUFZ@1224|Proteobacteria,2TRGN@28211|Alphaproteobacteria,2KF1P@204458|Caulobacterales	204458|Caulobacterales	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom
SHD2_k127_7944610_8	402881.Plav_2830	1.076e-239	761.0	COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,2TRC1@28211|Alphaproteobacteria,1JN2R@119043|Rhodobiaceae	28211|Alphaproteobacteria	J	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	GO:0000175,GO:0003674,GO:0003724,GO:0003824,GO:0004386,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008408,GO:0008997,GO:0009056,GO:0009057,GO:0009266,GO:0009409,GO:0009628,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016462,GO:0016787,GO:0016788,GO:0016796,GO:0016817,GO:0016818,GO:0016896,GO:0017111,GO:0019222,GO:0019439,GO:0034458,GO:0034470,GO:0034641,GO:0034655,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140098,GO:1901360,GO:1901361,GO:1901575	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	RNB,S1
SHD2_k127_7944610_76	342610.Patl_2625	1.092e-61	220.0	COG1051@1|root,COG1051@2|Bacteria,1QU5T@1224|Proteobacteria,1SC4D@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
SHD2_k127_7944610_52	1333998.M2A_3305	1.16e-90	315.0	COG0477@1|root,COG2814@2|Bacteria,1MVUF@1224|Proteobacteria,2TU4M@28211|Alphaproteobacteria,4BRZ2@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	EGP	MFS_1 like family	yfkF	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like,Sugar_tr
SHD2_k127_7944610_114	314260.PB2503_09089	2.752e-20	92.0	COG0267@1|root,COG0267@2|Bacteria,1N6QV@1224|Proteobacteria,2UF4D@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Belongs to the bacterial ribosomal protein bL33 family	rpmG	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02913	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L33
SHD2_k127_7944610_62	1282876.BAOK01000002_gene688	1.917e-79	274.0	COG2267@1|root,COG2267@2|Bacteria,1MX0N@1224|Proteobacteria,2TVZ2@28211|Alphaproteobacteria,4BQZC@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	I	Ndr family	-	-	3.1.1.24	ko:K01055	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00568	R02991	RC00825	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1,Abhydrolase_4
SHD2_k127_7944610_20	1333998.M2A_1970	1.395e-159	520.0	COG0578@1|root,COG0578@2|Bacteria,1MUMY@1224|Proteobacteria,2TU11@28211|Alphaproteobacteria,4BPQ9@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	C-terminal domain of alpha-glycerophosphate oxidase	-	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,DAO_C
SHD2_k127_7944610_70	1282876.BAOK01000002_gene683	3.344e-75	263.0	COG1597@1|root,COG1597@2|Bacteria,1RCJT@1224|Proteobacteria,2U7IG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Diacylglycerol kinase	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
SHD2_k127_7944610_16	402881.Plav_1669	5.772e-180	580.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2TR2Z@28211|Alphaproteobacteria,1JMZW@119043|Rhodobiaceae	28211|Alphaproteobacteria	C	FAD linked oxidases, C-terminal domain	-	-	2.5.1.26	ko:K00803	ko00565,ko01100,ko04146,map00565,map01100,map04146	-	R04311	RC00020,RC02886	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
SHD2_k127_7944610_50	1282876.BAOK01000002_gene681	6.219e-94	319.0	COG0657@1|root,COG0657@2|Bacteria,1NEXK@1224|Proteobacteria,2U5X1@28211|Alphaproteobacteria,4BQU9@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	I	alpha/beta hydrolase fold	-	-	-	ko:K01066	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_3
SHD2_k127_7944610_53	1282876.BAOK01000002_gene681	2.118e-90	308.0	COG0657@1|root,COG0657@2|Bacteria,1NEXK@1224|Proteobacteria,2U5X1@28211|Alphaproteobacteria,4BQU9@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	I	alpha/beta hydrolase fold	-	-	-	ko:K01066	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_3
SHD2_k127_7944610_98	1177928.TH2_07706	5.288e-39	149.0	COG2258@1|root,COG2258@2|Bacteria,1PVVH@1224|Proteobacteria,2UNAM@28211|Alphaproteobacteria,2JYAB@204441|Rhodospirillales	204441|Rhodospirillales	S	MOSC domain	-	-	-	-	-	-	-	-	-	-	-	-	MOSC
SHD2_k127_7944610_7	402881.Plav_1661	7.251e-256	802.0	COG0318@1|root,COG0318@2|Bacteria,1MUQZ@1224|Proteobacteria,2TRV7@28211|Alphaproteobacteria,1JPTF@119043|Rhodobiaceae	28211|Alphaproteobacteria	IQ	AMP-binding enzyme	-	-	6.2.1.34	ko:K12508	-	-	-	-	ko00000,ko01000	-	-	-	AMP-binding
SHD2_k127_7944610_17	402881.Plav_3656	8.712e-177	566.0	COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,2TRN1@28211|Alphaproteobacteria,1JN4D@119043|Rhodobiaceae	28211|Alphaproteobacteria	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	-	4.1.1.36,6.3.2.5	ko:K13038,ko:K21977	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
SHD2_k127_7944610_86	991905.SL003B_0044	8.222e-54	198.0	COG0756@1|root,COG0756@2|Bacteria,1RA7P@1224|Proteobacteria,2U7B5@28211|Alphaproteobacteria,4BQCP@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	F	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA	dut	GO:0000287,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576	3.6.1.23	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00053	R02100,R11896	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	dUTPase
SHD2_k127_7944610_88	1333998.M2A_0336	8.283e-52	186.0	COG1959@1|root,COG1959@2|Bacteria,1RIJ8@1224|Proteobacteria,2U744@28211|Alphaproteobacteria,4BSMZ@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
SHD2_k127_7944610_22	176299.Atu0312	7.487e-157	499.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,2TS33@28211|Alphaproteobacteria,4B7NI@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Cysteine synthase	cysK	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
SHD2_k127_7944610_48	1298867.AUES01000028_gene2584	3.798e-95	317.0	COG2050@1|root,COG2050@2|Bacteria,1R5RX@1224|Proteobacteria,2U1DZ@28211|Alphaproteobacteria,3JVKP@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Thioesterase-like superfamily	MA20_24410	-	-	-	-	-	-	-	-	-	-	-	4HBT_3
SHD2_k127_7944610_101	1205680.CAKO01000035_gene316	1.019e-35	143.0	COG0454@1|root,COG0456@2|Bacteria,1N6QA@1224|Proteobacteria,2UFGS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
SHD2_k127_7944610_90	1205680.CAKO01000025_gene4616	1.412e-51	190.0	COG0412@1|root,COG0412@2|Bacteria,1NKIB@1224|Proteobacteria,2U933@28211|Alphaproteobacteria,2JTNN@204441|Rhodospirillales	204441|Rhodospirillales	Q	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	DLH
SHD2_k127_7944610_85	395964.KE386496_gene165	1.375e-54	195.0	COG0346@1|root,COG0346@2|Bacteria,1N116@1224|Proteobacteria,2VAK0@28211|Alphaproteobacteria,3NCTB@45404|Beijerinckiaceae	28211|Alphaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
SHD2_k127_7944610_71	402881.Plav_0208	4.585e-73	258.0	COG0584@1|root,COG0584@2|Bacteria,1MW6Z@1224|Proteobacteria	1224|Proteobacteria	C	glycerophosphoryl diester phosphodiesterase	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
SHD2_k127_7944610_15	1333998.M2A_1939	1.844e-212	666.0	COG1960@1|root,COG1960@2|Bacteria,1MWUU@1224|Proteobacteria,2TT47@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
SHD2_k127_7944610_128	1343740.M271_40405	7.684e-05	52.0	COG3631@1|root,COG3631@2|Bacteria,2II8D@201174|Actinobacteria	201174|Actinobacteria	S	COG3631 Ketosteroid isomerase-related protein	-	-	-	ko:K06893	-	-	-	-	ko00000	-	-	-	SnoaL_2
SHD2_k127_7944610_44	1205680.CAKO01000042_gene5452	4.256e-99	340.0	COG0534@1|root,COG0534@2|Bacteria,1MUAM@1224|Proteobacteria,2TSDU@28211|Alphaproteobacteria,2JPD5@204441|Rhodospirillales	204441|Rhodospirillales	V	MatE	norM	-	-	ko:K03327	-	-	-	-	ko00000,ko02000	2.A.66.1	-	-	MatE
SHD2_k127_7944610_21	1333998.M2A_0341	6.439e-159	519.0	COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,2TS87@28211|Alphaproteobacteria,4BP6M@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis	ubiB	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1
SHD2_k127_7944610_49	439375.Oant_1317	4.144e-95	317.0	COG0500@1|root,COG2226@2|Bacteria,1MX8I@1224|Proteobacteria,2TRWR@28211|Alphaproteobacteria,1J1W2@118882|Brucellaceae	28211|Alphaproteobacteria	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)	ubiE	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
SHD2_k127_7944610_45	1402135.SUH3_10075	3.646e-98	331.0	COG0266@1|root,COG0266@2|Bacteria,1MVM5@1224|Proteobacteria,2TS4C@28211|Alphaproteobacteria,3ZVUG@60136|Sulfitobacter	28211|Alphaproteobacteria	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	fpg	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
SHD2_k127_7944610_118	69395.JQLZ01000003_gene370	2.726e-11	66.0	COG3847@1|root,COG3847@2|Bacteria,1NGVU@1224|Proteobacteria,2UJE8@28211|Alphaproteobacteria,2KHE0@204458|Caulobacterales	204458|Caulobacterales	U	Flp Fap pilin component	-	-	-	ko:K02651	ko04112,map04112	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	Flp_Fap
SHD2_k127_7944610_80	1458357.BG58_14970	7.326e-58	208.0	COG3832@1|root,COG3832@2|Bacteria,1RB46@1224|Proteobacteria,2VTVP@28216|Betaproteobacteria,1K8WI@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
SHD2_k127_7944610_89	1040983.AXAE01000038_gene2538	1.086e-51	184.0	COG0640@1|root,COG0640@2|Bacteria,1RIJ9@1224|Proteobacteria,2U9ZV@28211|Alphaproteobacteria,43PPD@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
SHD2_k127_7944610_36	402881.Plav_3661	4.601e-113	370.0	COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,2TRYS@28211|Alphaproteobacteria,1JNH3@119043|Rhodobiaceae	28211|Alphaproteobacteria	I	PFAM Enoyl-CoA hydratase isomerase	MA20_15895	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
SHD2_k127_7944610_110	1122218.KB893654_gene2378	8.889e-23	100.0	COG0268@1|root,COG0268@2|Bacteria,1MZ94@1224|Proteobacteria,2UC42@28211|Alphaproteobacteria,1JVUW@119045|Methylobacteriaceae	28211|Alphaproteobacteria	J	Binds directly to 16S ribosomal RNA	rpsT	-	-	ko:K02968	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S20p
SHD2_k127_7944610_84	402881.Plav_0002	2.592e-55	197.0	COG0607@1|root,COG0607@2|Bacteria,1REHH@1224|Proteobacteria,2UBVU@28211|Alphaproteobacteria,1JP2H@119043|Rhodobiaceae	28211|Alphaproteobacteria	P	Rhodanese Homology Domain	pspE	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
SHD2_k127_7944610_51	402881.Plav_0003	2.22e-91	318.0	COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,2TT03@28211|Alphaproteobacteria,1JNK5@119043|Rhodobiaceae	28211|Alphaproteobacteria	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
SHD2_k127_7944610_25	1207063.P24_14799	2.579e-140	458.0	COG0592@1|root,COG0592@2|Bacteria,1MVD9@1224|Proteobacteria,2TSRZ@28211|Alphaproteobacteria,2JQAW@204441|Rhodospirillales	204441|Rhodospirillales	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	dnaN	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
SHD2_k127_7944610_41	1121033.AUCF01000011_gene1812	8.064e-106	357.0	COG1195@1|root,COG1195@2|Bacteria,1MX8N@1224|Proteobacteria,2TQRD@28211|Alphaproteobacteria,2JP8E@204441|Rhodospirillales	204441|Rhodospirillales	L	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP	recF	-	-	ko:K03629	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	AAA_21,AAA_23,SMC_N
SHD2_k127_7944610_1	991905.SL003B_0004	0.0	1172.0	COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,2TRBK@28211|Alphaproteobacteria,4BPJS@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
SHD2_k127_7944610_67	1333998.M2A_2413	1.461e-77	268.0	COG0500@1|root,COG2226@2|Bacteria,1PPKI@1224|Proteobacteria,2TRIB@28211|Alphaproteobacteria,4BSGF@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	Q	ubiE/COQ5 methyltransferase family	MA20_37085	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
SHD2_k127_7944610_87	1380355.JNIJ01000035_gene4383	9.305e-54	197.0	COG1247@1|root,COG1247@2|Bacteria,1QU6J@1224|Proteobacteria,2TW1P@28211|Alphaproteobacteria,3K6KT@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
SHD2_k127_7944610_12	1168059.KB899087_gene3969	1.733e-226	705.0	COG0137@1|root,COG0137@2|Bacteria,1MV0Y@1224|Proteobacteria,2TTGS@28211|Alphaproteobacteria,3EY4B@335928|Xanthobacteraceae	28211|Alphaproteobacteria	E	argininosuccinate synthase activity	argG	GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
SHD2_k127_7944610_66	402881.Plav_1378	5.191e-78	268.0	COG3917@1|root,COG3917@2|Bacteria,1RDNQ@1224|Proteobacteria,2VGB4@28211|Alphaproteobacteria,1JP4N@119043|Rhodobiaceae	28211|Alphaproteobacteria	Q	DSBA-like thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	DSBA
SHD2_k127_7944610_46	1206731.BAGB01000047_gene5175	6.41e-98	325.0	COG1028@1|root,COG1028@2|Bacteria,2GK47@201174|Actinobacteria,4FXVP@85025|Nocardiaceae	201174|Actinobacteria	IQ	KR domain	ydaD	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
SHD2_k127_7944610_18	936136.ARRT01000006_gene5484	2.652e-167	536.0	COG0820@1|root,COG0820@2|Bacteria,1MUYK@1224|Proteobacteria,2TQT3@28211|Alphaproteobacteria,4B82E@82115|Rhizobiaceae	28211|Alphaproteobacteria	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Radical_SAM
SHD2_k127_7944610_102	1122132.AQYH01000007_gene2099	3.567e-32	132.0	COG5342@1|root,COG5342@2|Bacteria,1R46Z@1224|Proteobacteria,2VGJG@28211|Alphaproteobacteria,4BNKC@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	invasion associated locus B	-	-	-	-	-	-	-	-	-	-	-	-	IalB
SHD2_k127_7944610_64	1038859.AXAU01000008_gene1995	1.637e-78	269.0	COG3917@1|root,COG3917@2|Bacteria,1RA6I@1224|Proteobacteria,2U5JB@28211|Alphaproteobacteria,3JRJN@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	DSBA-like thioredoxin domain	MA20_25040	-	5.99.1.4	ko:K14584	ko00626,ko01100,ko01120,ko01220,map00626,map01100,map01120,map01220	M00534	R05137	RC03084	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	DSBA
SHD2_k127_7944610_32	1280954.HPO_07939	4.228e-120	391.0	COG1028@1|root,COG1028@2|Bacteria,1MWJQ@1224|Proteobacteria,2TVRP@28211|Alphaproteobacteria,43WKB@69657|Hyphomonadaceae	28211|Alphaproteobacteria	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	MA20_07325	-	-	-	-	-	-	-	-	-	-	-	adh_short
SHD2_k127_7944610_94	227377.CBU_0933	4.05e-43	169.0	COG0842@1|root,COG0842@2|Bacteria,1MUH1@1224|Proteobacteria,1RP0Z@1236|Gammaproteobacteria,1JDR8@118969|Legionellales	118969|Legionellales	U	ABC-2 type transporter	yadH	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
SHD2_k127_7944610_63	1380390.JIAT01000010_gene4556	4.869e-79	273.0	COG1131@1|root,COG1131@2|Bacteria,2IBZE@201174|Actinobacteria,4CPJZ@84995|Rubrobacteria	84995|Rubrobacteria	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SHD2_k127_7944610_79	991905.SL003B_0175	1.493e-59	214.0	COG0566@1|root,COG0566@2|Bacteria,1REIN@1224|Proteobacteria,2U76Y@28211|Alphaproteobacteria,4BQ4J@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	J	SpoU rRNA Methylase family	-	-	-	-	-	-	-	-	-	-	-	-	SpoU_methylase
SHD2_k127_7944610_54	1207063.P24_03645	5.539e-89	304.0	COG4448@1|root,COG4448@2|Bacteria,1R4NH@1224|Proteobacteria,2TV9J@28211|Alphaproteobacteria,2JQI6@204441|Rhodospirillales	204441|Rhodospirillales	E	L-asparaginase II	-	-	-	-	-	-	-	-	-	-	-	-	Asparaginase_II
SHD2_k127_7944610_27	1333998.M2A_0719	7.682e-129	420.0	COG0604@1|root,COG0604@2|Bacteria,1MWRK@1224|Proteobacteria,2TQMF@28211|Alphaproteobacteria,4BPZE@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Zinc-binding dehydrogenase	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
SHD2_k127_7944610_26	1336243.JAEA01000012_gene3020	3.652e-132	434.0	COG1914@1|root,COG1914@2|Bacteria,1MW6X@1224|Proteobacteria,2TRNM@28211|Alphaproteobacteria,1JTZK@119045|Methylobacteriaceae	28211|Alphaproteobacteria	P	Natural resistance-associated macrophage protein	-	-	-	-	-	-	-	-	-	-	-	-	Nramp
SHD2_k127_7944610_109	864069.MicloDRAFT_00010630	7.424e-23	100.0	COG2261@1|root,COG2261@2|Bacteria,1NNKP@1224|Proteobacteria,2UGGY@28211|Alphaproteobacteria,1JW92@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Transglycosylase associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
SHD2_k127_7944610_5	1030157.AFMP01000040_gene1510	3.981e-298	923.0	COG0422@1|root,COG0422@2|Bacteria,1MUVV@1224|Proteobacteria,2TS0S@28211|Alphaproteobacteria,2JZYN@204457|Sphingomonadales	204457|Sphingomonadales	H	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction	thiC	-	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC-associated,ThiC_Rad_SAM
SHD2_k127_7944610_96	2002.JOEQ01000017_gene7795	3.865e-42	159.0	COG0454@1|root,COG0456@2|Bacteria,2IHUH@201174|Actinobacteria,4EQ9H@85012|Streptosporangiales	201174|Actinobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_7,CM_2
SHD2_k127_7944610_122	366602.Caul_0779	1.652e-09	62.0	2EI68@1|root,33BXK@2|Bacteria,1NH2E@1224|Proteobacteria,2UJAP@28211|Alphaproteobacteria,2KHIP@204458|Caulobacterales	204458|Caulobacterales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_7944610_39	314254.OA2633_10749	3.542e-108	355.0	COG1402@1|root,COG1402@2|Bacteria,1MXR9@1224|Proteobacteria,2TUFR@28211|Alphaproteobacteria,43X4J@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	Creatininase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
SHD2_k127_7944610_121	1120950.KB892765_gene5655	1.424e-09	70.0	COG1708@1|root,COG1708@2|Bacteria,2IK73@201174|Actinobacteria,4DS51@85009|Propionibacteriales	201174|Actinobacteria	S	nucleotidyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Adenyl_transf
SHD2_k127_7944610_104	1379698.RBG1_1C00001G0272	9.947e-31	129.0	COG3832@1|root,COG3832@2|Bacteria	2|Bacteria	J	glyoxalase III activity	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1,DUF2505
SHD2_k127_7944610_43	46429.BV95_03302	2.431e-105	355.0	COG1804@1|root,COG1804@2|Bacteria,1MVY1@1224|Proteobacteria,2TVJ9@28211|Alphaproteobacteria,2K3N7@204457|Sphingomonadales	204457|Sphingomonadales	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
SHD2_k127_7944610_119	1122915.AUGY01000012_gene3916	4.211e-11	70.0	arCOG13956@1|root,33BWW@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_7944610_69	204669.Acid345_0180	2.671e-75	259.0	COG0785@1|root,COG0785@2|Bacteria	2|Bacteria	O	Cytochrome C biogenesis protein	ccdA	-	1.8.4.11,1.8.4.12	ko:K06196,ko:K12267	-	-	-	-	ko00000,ko01000,ko02000	5.A.1.2	-	-	AhpC-TSA,DsbD
SHD2_k127_7944610_99	1267533.KB906733_gene3028	7.338e-38	151.0	COG0526@1|root,COG0526@2|Bacteria,3Y4K8@57723|Acidobacteria,2JJAP@204432|Acidobacteriia	204432|Acidobacteriia	CO	Glutathione peroxidase	-	-	-	ko:K02199	-	-	-	-	ko00000,ko03110	-	-	-	AhpC-TSA
SHD2_k127_7944610_111	861299.J421_6000	3.996e-22	103.0	COG0789@1|root,COG0789@2|Bacteria,1ZVAN@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	MerR, DNA binding	-	-	-	ko:K13639	-	-	-	-	ko00000,ko03000	-	-	-	-
SHD2_k127_7944610_3	402881.Plav_1331	0.0	1075.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2TRKS@28211|Alphaproteobacteria,1JNID@119043|Rhodobiaceae	28211|Alphaproteobacteria	F	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
SHD2_k127_7944610_42	1333998.M2A_0141	8.321e-106	350.0	COG0491@1|root,COG0491@2|Bacteria,1N22F@1224|Proteobacteria,2U2V5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
SHD2_k127_7944610_92	1415630.U771_10895	2.147e-48	179.0	COG0431@1|root,COG0431@2|Bacteria,1N305@1224|Proteobacteria,1S4S5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	NAD(P)H-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
SHD2_k127_7944610_106	4787.PITG_05851T0	4.183e-30	124.0	COG2154@1|root,KOG4073@2759|Eukaryota,3QFRX@4776|Peronosporales	4776|Peronosporales	K	Pterin 4 alpha carbinolamine dehydratase	-	-	4.2.1.96	ko:K01724	ko00790,map00790	-	R04734	RC01208	ko00000,ko00001,ko01000,ko04147	-	-	-	Pterin_4a
SHD2_k127_7944610_95	1281779.H009_18463	5.019e-43	163.0	COG1514@1|root,COG1514@2|Bacteria,1RDB2@1224|Proteobacteria,2U7FV@28211|Alphaproteobacteria,4B87C@82115|Rhizobiaceae	28211|Alphaproteobacteria	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	ligT	-	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
SHD2_k127_7944610_14	717785.HYPMC_1365	1.757e-213	673.0	COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,2TS44@28211|Alphaproteobacteria,3N6AR@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
SHD2_k127_7944610_77	1121440.AUMA01000021_gene199	1.244e-61	219.0	COG2755@1|root,COG2755@2|Bacteria,1RCXZ@1224|Proteobacteria,42SUC@68525|delta/epsilon subdivisions,2WPR4@28221|Deltaproteobacteria,2MAWJ@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	PFAM lipolytic protein G-D-S-L family	-	-	3.1.1.5	ko:K10804	ko01040,map01040	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	-	Lipase_GDSL_2
SHD2_k127_7944610_97	1380391.JIAS01000014_gene1948	1.462e-39	153.0	COG5388@1|root,COG5388@2|Bacteria,1NENP@1224|Proteobacteria,2UINR@28211|Alphaproteobacteria,2JTY0@204441|Rhodospirillales	204441|Rhodospirillales	S	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	PAS_5
SHD2_k127_7944610_126	504832.OCAR_6495	5.007e-05	50.0	2BSV4@1|root,32MYP@2|Bacteria,1PG60@1224|Proteobacteria,2V7II@28211|Alphaproteobacteria,3K1WG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	PilZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PilZ
SHD2_k127_7944610_55	1333998.M2A_0734	3.631e-88	297.0	COG4181@1|root,COG4181@2|Bacteria,1MXG9@1224|Proteobacteria,2TS0J@28211|Alphaproteobacteria,4BPZJ@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	Q	ABC transporter	ybbA	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SHD2_k127_7944610_9	1333998.M2A_0735	2.29e-231	742.0	COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,2TS8V@28211|Alphaproteobacteria,4BP6I@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	Q	FtsX-like permease family	MA20_43810	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
SHD2_k127_7944610_56	438753.AZC_0959	7.686e-88	296.0	COG0670@1|root,COG0670@2|Bacteria,1MU69@1224|Proteobacteria,2TRSF@28211|Alphaproteobacteria,3EZ4A@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	Belongs to the BI1 family	ybhL	-	-	ko:K06890	-	-	-	-	ko00000	-	-	-	Bax1-I
SHD2_k127_7944610_61	1415166.NONO_c36050	7.982e-81	278.0	COG1024@1|root,COG1024@2|Bacteria,2GJDK@201174|Actinobacteria,4FX4V@85025|Nocardiaceae	201174|Actinobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	5.3.3.18	ko:K15866	ko00360,ko01120,map00360,map01120	-	R09837,R09839	RC00004,RC00326,RC02689,RC03003	ko00000,ko00001,ko01000	-	-	-	ECH_1,SnoaL_2
SHD2_k127_7944610_100	864069.MicloDRAFT_00060190	3.739e-37	145.0	2CCMQ@1|root,32RW3@2|Bacteria,1MZHB@1224|Proteobacteria,2UCC9@28211|Alphaproteobacteria,1JVA5@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF2794)	MA20_43795	-	-	-	-	-	-	-	-	-	-	-	DUF2794
SHD2_k127_7944610_72	1380394.JADL01000011_gene4006	3.616e-72	250.0	COG4122@1|root,COG4122@2|Bacteria,1RB34@1224|Proteobacteria,2VGIH@28211|Alphaproteobacteria,2JS0H@204441|Rhodospirillales	204441|Rhodospirillales	S	O-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_3
SHD2_k127_7944610_33	402881.Plav_1397	8.111e-118	389.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,2TR2P@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SHD2_k127_7944610_40	402881.Plav_1398	5.993e-106	348.0	COG1277@1|root,COG1277@2|Bacteria,1NZZ9@1224|Proteobacteria,2TUXR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	N	ABC transporter permease	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_3
SHD2_k127_7944610_19	1282876.BAOK01000002_gene387	9.678e-167	544.0	COG3225@1|root,COG3225@2|Bacteria,1MY63@1224|Proteobacteria,2U1SX@28211|Alphaproteobacteria,4BPZ2@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	N	ABC-type uncharacterized transport system	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_transp_aux
SHD2_k127_7944610_113	243233.MCA1564	1.199e-20	105.0	2DM5E@1|root,31SVN@2|Bacteria,1MYKR@1224|Proteobacteria,1SF2N@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF4340)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4340
SHD2_k127_7944610_37	1282876.BAOK01000001_gene2640	7.518e-112	372.0	COG4638@1|root,COG4638@2|Bacteria,1MX47@1224|Proteobacteria,2VG2H@28211|Alphaproteobacteria,4BR1X@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	P	Rieske [2Fe-2S] domain	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
SHD2_k127_7944610_0	450851.PHZ_c2588	0.0	1489.0	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,2TQZU@28211|Alphaproteobacteria,2KF84@204458|Caulobacterales	204458|Caulobacterales	F	Belongs to the CarB family	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
SHD2_k127_7944610_83	1382303.JPOM01000001_gene2594	5.804e-56	198.0	COG0782@1|root,COG0782@2|Bacteria,1RCXW@1224|Proteobacteria,2U5JU@28211|Alphaproteobacteria,2KGAN@204458|Caulobacterales	204458|Caulobacterales	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	-	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
SHD2_k127_7987113_12	450851.PHZ_c2561	3.124e-75	257.0	COG2070@1|root,COG2070@2|Bacteria,1P5WC@1224|Proteobacteria,2U490@28211|Alphaproteobacteria,2KIAF@204458|Caulobacterales	204458|Caulobacterales	S	Nitronate monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	NMO
SHD2_k127_7987113_1	331869.BAL199_29235	1.104e-192	615.0	COG2072@1|root,COG2072@2|Bacteria,1MUQH@1224|Proteobacteria,2TRG4@28211|Alphaproteobacteria,4BRUQ@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Flavin-binding monooxygenase-like	-	-	1.14.13.22	ko:K03379	ko00930,ko01120,ko01220,map00930,map01120,map01220	-	R02231,R06622	RC00662,RC01550	ko00000,ko00001,ko01000	-	-	-	FMO-like,Pyr_redox_3
SHD2_k127_7987113_16	1174528.JH992893_gene5999	4.07e-14	81.0	COG0346@1|root,COG3193@1|root,COG0346@2|Bacteria,COG3193@2|Bacteria,1GERW@1117|Cyanobacteria	1117|Cyanobacteria	E	Haem-degrading	-	-	-	-	-	-	-	-	-	-	-	-	Haem_degrading
SHD2_k127_7987113_8	450851.PHZ_c0283	4.874e-91	306.0	COG1024@1|root,COG1024@2|Bacteria,1MXHV@1224|Proteobacteria,2TTEG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	MA20_06735	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
SHD2_k127_7987113_13	158500.BV97_01168	1.59e-73	276.0	COG1629@1|root,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,2UQDB@28211|Alphaproteobacteria,2K9WI@204457|Sphingomonadales	204457|Sphingomonadales	P	TonB dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
SHD2_k127_7987113_10	402881.Plav_0870	3.198e-80	278.0	COG0657@1|root,COG0657@2|Bacteria,1RD8A@1224|Proteobacteria,2U1B8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Alpha beta hydrolase	-	-	3.1.1.83	ko:K14731	ko00903,ko00930,ko01220,map00903,map00930,map01220	-	R03751,R06390,R06391,R06392,R06393	RC00713,RC00983,RC01505	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_3
SHD2_k127_7987113_9	1333998.M2A_1986	9.763e-88	299.0	COG1028@1|root,COG1028@2|Bacteria,1MUPX@1224|Proteobacteria,2TT6C@28211|Alphaproteobacteria	28211|Alphaproteobacteria	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	MA20_30510	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
SHD2_k127_7987113_17	1235279.C772_01651	5.593e-12	74.0	COG1309@1|root,COG1309@2|Bacteria,1UHPV@1239|Firmicutes,4IS5Q@91061|Bacilli,26IGZ@186818|Planococcaceae	91061|Bacilli	K	BetI-type transcriptional repressor, C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_6,TetR_N
SHD2_k127_7987113_18	392499.Swit_1616	9.63e-07	57.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	5.1.99.1	ko:K05606	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R02765,R09979	RC00780,RC02739	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase
SHD2_k127_7987113_4	1048339.KB913029_gene2967	4.298e-107	356.0	COG1878@1|root,COG1878@2|Bacteria,2GJ59@201174|Actinobacteria,4EVXM@85013|Frankiales	201174|Actinobacteria	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
SHD2_k127_7987113_5	215803.DB30_6242	4.016e-106	357.0	COG2141@1|root,COG2141@2|Bacteria,1MX64@1224|Proteobacteria,42RHK@68525|delta/epsilon subdivisions,2X35S@28221|Deltaproteobacteria,2YUDQ@29|Myxococcales	28221|Deltaproteobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
SHD2_k127_7987113_0	1030157.AFMP01000032_gene403	6.079e-220	698.0	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,2TSZZ@28211|Alphaproteobacteria,2JZXP@204457|Sphingomonadales	204457|Sphingomonadales	Q	COG3653 N-acyl-D-aspartate D-glutamate deacylase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
SHD2_k127_7987113_3	298655.KI912266_gene4051	3.62e-115	385.0	COG2159@1|root,COG2159@2|Bacteria,2GKG2@201174|Actinobacteria	201174|Actinobacteria	S	Pfam Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
SHD2_k127_7987113_11	1535422.ND16A_3450	7.679e-79	269.0	COG0625@1|root,COG0625@2|Bacteria,1RAIN@1224|Proteobacteria,1S3Q5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Belongs to the GST superfamily	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_2,GST_N,GST_N_3
SHD2_k127_7987113_20	864069.MicloDRAFT_00013920	0.0001116	51.0	2EM9G@1|root,33EYK@2|Bacteria,1P8EM@1224|Proteobacteria,2UYGB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_7987113_14	1304878.AUGD01000004_gene5253	5.209e-62	226.0	2919Q@1|root,32EZ8@2|Bacteria,1R3DK@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_7987113_7	1234595.C725_2496	3.235e-95	316.0	COG0625@1|root,COG0625@2|Bacteria,1PBD7@1224|Proteobacteria,2U0HQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Belongs to the GST superfamily	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_N,GST_N_3
SHD2_k127_7987113_6	1313172.YM304_26030	1.444e-101	344.0	COG2159@1|root,COG2159@2|Bacteria,2GKAB@201174|Actinobacteria	201174|Actinobacteria	S	PFAM Amidohydrolase 2	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
SHD2_k127_7987113_2	1267534.KB906754_gene3350	1.165e-167	541.0	COG0457@1|root,COG0457@2|Bacteria,3Y46H@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_7987113_15	1161401.ASJA01000008_gene1608	1.123e-51	189.0	COG1595@1|root,COG1595@2|Bacteria,1MZMC@1224|Proteobacteria,2TUUZ@28211|Alphaproteobacteria,43W7Y@69657|Hyphomonadaceae	28211|Alphaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
SHD2_k127_8208926_42	1267005.KB911257_gene692	3.528e-73	256.0	COG0644@1|root,COG0644@2|Bacteria,1Q5UG@1224|Proteobacteria,2UQI2@28211|Alphaproteobacteria,3N843@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_8208926_17	1122604.JONR01000020_gene470	5.109e-117	388.0	COG0477@1|root,COG2814@2|Bacteria,1MXPM@1224|Proteobacteria	1224|Proteobacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SHD2_k127_8208926_34	535289.Dtpsy_0707	1.515e-83	286.0	COG2518@1|root,COG2518@2|Bacteria,1NMMQ@1224|Proteobacteria,2VH3B@28216|Betaproteobacteria,4ACAP@80864|Comamonadaceae	28216|Betaproteobacteria	O	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_32
SHD2_k127_8208926_0	1336243.JAEA01000007_gene721	0.0	1002.0	COG0481@1|root,COG0481@2|Bacteria,1MVZA@1224|Proteobacteria,2TR3H@28211|Alphaproteobacteria,1JR8Z@119045|Methylobacteriaceae	28211|Alphaproteobacteria	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2,LepA_C
SHD2_k127_8208926_45	1120792.JAFV01000001_gene2854	1.183e-64	224.0	COG2510@1|root,COG2510@2|Bacteria,1RJ4E@1224|Proteobacteria,2U7CK@28211|Alphaproteobacteria,370FV@31993|Methylocystaceae	28211|Alphaproteobacteria	S	EamA-like transporter family	-	-	-	ko:K08978	-	-	-	-	ko00000,ko02000	2.A.7.2	-	-	EamA
SHD2_k127_8208926_36	1168059.KB899087_gene3555	1.128e-82	280.0	COG0118@1|root,COG0118@2|Bacteria,1MU4X@1224|Proteobacteria,2TTT4@28211|Alphaproteobacteria,3EY4P@335928|Xanthobacteraceae	28211|Alphaproteobacteria	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	-	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
SHD2_k127_8208926_25	402881.Plav_1234	7.128e-95	317.0	COG0106@1|root,COG0106@2|Bacteria,1MW6S@1224|Proteobacteria,2TRSG@28211|Alphaproteobacteria,1JN3R@119043|Rhodobiaceae	28211|Alphaproteobacteria	E	Histidine biosynthesis protein	hisA	GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
SHD2_k127_8208926_27	1333998.M2A_0196	8.054e-94	317.0	COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,2TSTN@28211|Alphaproteobacteria,4BPZM@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	K	Belongs to the ParB family	parB	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
SHD2_k127_8208926_22	1035191.HMPREF0185_00409	1.34e-109	361.0	COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,2TSWH@28211|Alphaproteobacteria,2KFAA@204458|Caulobacterales	204458|Caulobacterales	D	Chromosome partitioning protein ParA	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
SHD2_k127_8208926_53	1121033.AUCF01000003_gene3391	3.762e-50	185.0	COG0357@1|root,COG0357@2|Bacteria,1MY0K@1224|Proteobacteria,2U9T9@28211|Alphaproteobacteria,2JS6N@204441|Rhodospirillales	204441|Rhodospirillales	J	Specifically methylates the N7 position of guanine in position 527 of 16S rRNA	rsmG	-	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB
SHD2_k127_8208926_1	1333998.M2A_0199	1.461e-277	864.0	COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,2TRJS@28211|Alphaproteobacteria,4BPAN@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
SHD2_k127_8208926_9	1238182.C882_3232	5.562e-138	452.0	COG0486@1|root,COG0486@2|Bacteria,1MUCQ@1224|Proteobacteria,2TQZW@28211|Alphaproteobacteria,2JP8P@204441|Rhodospirillales	204441|Rhodospirillales	J	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34	mnmE	-	-	ko:K03650	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko01000,ko03016	-	-	-	MMR_HSR1,MnmE_helical,TrmE_N
SHD2_k127_8208926_61	414684.RC1_2807	2.631e-17	85.0	COG3266@1|root,COG3266@2|Bacteria,1NC0S@1224|Proteobacteria,2UG0A@28211|Alphaproteobacteria,2JTJC@204441|Rhodospirillales	204441|Rhodospirillales	S	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_8208926_3	1121033.AUCF01000003_gene3396	8.397e-202	649.0	COG1331@1|root,COG1331@2|Bacteria,1MUUT@1224|Proteobacteria,2TV0X@28211|Alphaproteobacteria,2JPU1@204441|Rhodospirillales	204441|Rhodospirillales	O	COG1331 Highly conserved protein containing a thioredoxin domain	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	GlcNAc_2-epim,Thioredox_DsbH
SHD2_k127_8208926_31	1333998.M2A_0202	3.091e-89	312.0	COG0412@1|root,COG0412@2|Bacteria,1MW88@1224|Proteobacteria,2U1D8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	dienelactone hydrolase	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
SHD2_k127_8208926_8	1123257.AUFV01000021_gene1994	2.393e-145	489.0	COG2272@1|root,COG2272@2|Bacteria,1MVQZ@1224|Proteobacteria,1RPFW@1236|Gammaproteobacteria,1X4ZQ@135614|Xanthomonadales	135614|Xanthomonadales	I	Belongs to the type-B carboxylesterase lipase family	-	-	-	ko:K03929	-	-	-	-	ko00000,ko01000	-	CE10	-	COesterase
SHD2_k127_8208926_6	450851.PHZ_c1260	2.716e-151	492.0	COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,2TUEW@28211|Alphaproteobacteria,2KFDV@204458|Caulobacterales	204458|Caulobacterales	EGP	PFAM Major Facilitator Superfamily	-	-	-	ko:K08151	-	M00668	-	-	ko00000,ko00002,ko01504,ko02000	2.A.1.2.38,2.A.1.2.39,2.A.1.2.4,2.A.1.2.41,2.A.1.2.68,2.A.1.2.75	-	-	MFS_1
SHD2_k127_8208926_15	1031711.RSPO_c01250	3.895e-124	406.0	COG0604@1|root,COG0604@2|Bacteria,1MWBD@1224|Proteobacteria,2VH3Z@28216|Betaproteobacteria,1K0ZE@119060|Burkholderiaceae	28216|Betaproteobacteria	C	PFAM Alcohol dehydrogenase zinc-binding domain protein	qor	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
SHD2_k127_8208926_37	1282876.BAOK01000002_gene181	1.958e-82	279.0	COG4341@1|root,COG4341@2|Bacteria,1QHQD@1224|Proteobacteria,2U1W2@28211|Alphaproteobacteria,4BTC2@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	-	-	-	-	-	-	-	-	-	HD
SHD2_k127_8208926_51	1244869.H261_06344	2.113e-50	187.0	COG2862@1|root,COG2862@2|Bacteria,1RANN@1224|Proteobacteria,2TSEF@28211|Alphaproteobacteria,2JTCC@204441|Rhodospirillales	204441|Rhodospirillales	S	Uncharacterized protein family, UPF0114	-	-	-	-	-	-	-	-	-	-	-	-	UPF0114
SHD2_k127_8208926_49	1068978.AMETH_6951	9.066e-53	194.0	COG0596@1|root,COG0596@2|Bacteria,2IFY9@201174|Actinobacteria,4E2WJ@85010|Pseudonocardiales	201174|Actinobacteria	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
SHD2_k127_8208926_2	1282362.AEAC466_00165	1.552e-232	725.0	COG1158@1|root,COG1158@2|Bacteria,1MUCF@1224|Proteobacteria,2TRB4@28211|Alphaproteobacteria,2KFVG@204458|Caulobacterales	204458|Caulobacterales	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
SHD2_k127_8208926_46	1245469.S58_02100	1.252e-54	196.0	COG1981@1|root,COG1981@2|Bacteria,1RHGS@1224|Proteobacteria,2U987@28211|Alphaproteobacteria,3JY1X@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Uncharacterised protein family (UPF0093)	MA20_24805	-	-	ko:K08973	-	-	-	-	ko00000	-	-	-	UPF0093
SHD2_k127_8208926_16	1110502.TMO_3406	7.906e-120	395.0	COG0276@1|root,COG0276@2|Bacteria,1MVR1@1224|Proteobacteria,2TSMS@28211|Alphaproteobacteria,2JPU6@204441|Rhodospirillales	204441|Rhodospirillales	H	Catalyzes the ferrous insertion into protoporphyrin IX	hemH	-	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	Ferrochelatase
SHD2_k127_8208926_18	1121033.AUCF01000003_gene3404	8.484e-115	379.0	COG0407@1|root,COG0407@2|Bacteria,1MUG1@1224|Proteobacteria,2TQQV@28211|Alphaproteobacteria,2JQYD@204441|Rhodospirillales	204441|Rhodospirillales	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	hemE	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
SHD2_k127_8208926_28	1282876.BAOK01000002_gene174	9.985e-93	313.0	COG1806@1|root,COG1806@2|Bacteria,1MUHU@1224|Proteobacteria,2TT66@28211|Alphaproteobacteria,4BPZ4@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation	MA20_24795	-	2.7.11.33,2.7.4.28	ko:K09773	-	-	-	-	ko00000,ko01000	-	-	-	Kinase-PPPase
SHD2_k127_8208926_47	1035191.HMPREF0185_00420	1.505e-54	198.0	COG0424@1|root,COG0424@2|Bacteria,1RDA9@1224|Proteobacteria,2U9H5@28211|Alphaproteobacteria,2KGRS@204458|Caulobacterales	204458|Caulobacterales	D	Maf-like protein	-	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
SHD2_k127_8208926_40	1238182.C882_3218	1.631e-73	260.0	COG0169@1|root,COG0169@2|Bacteria,1MVH4@1224|Proteobacteria,2TS99@28211|Alphaproteobacteria,2JPBD@204441|Rhodospirillales	204441|Rhodospirillales	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	-	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_DH,Shikimate_dh_N
SHD2_k127_8208926_41	1333998.M2A_0211	2.42e-73	254.0	COG0237@1|root,COG0237@2|Bacteria,1RCXT@1224|Proteobacteria,2U765@28211|Alphaproteobacteria,4BQDG@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	H	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CoaE
SHD2_k127_8208926_38	398580.Dshi_3448	5.235e-79	270.0	COG0847@1|root,COG0847@2|Bacteria,1MV8Z@1224|Proteobacteria,2TTFF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease	dnaQ	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
SHD2_k127_8208926_55	1122613.ATUP01000001_gene1389	1.133e-46	174.0	COG1952@1|root,COG1952@2|Bacteria,1RI75@1224|Proteobacteria,2UBTB@28211|Alphaproteobacteria,43XUP@69657|Hyphomonadaceae	28211|Alphaproteobacteria	U	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA	secB	GO:0002790,GO:0006457,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705	-	ko:K03071	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03110	3.A.5	-	-	SecB
SHD2_k127_8208926_50	1122929.KB908218_gene1517	1.747e-50	194.0	COG4395@1|root,COG4395@2|Bacteria,1NCIX@1224|Proteobacteria,2TTDQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	import inner membrane translocase, subunit Tim44	MA20_24770	-	-	-	-	-	-	-	-	-	-	-	Tim44
SHD2_k127_8208926_29	1282876.BAOK01000002_gene165	7.863e-90	310.0	COG2821@1|root,COG2821@2|Bacteria,1MXD4@1224|Proteobacteria,2TS5S@28211|Alphaproteobacteria,4BPND@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	M	MltA specific insert domain	mltA	-	-	ko:K08304	-	-	-	-	ko00000,ko01000,ko01011	-	GH102	-	3D,MltA
SHD2_k127_8208926_59	1122132.AQYH01000005_gene488	4.002e-28	122.0	COG2840@1|root,COG2840@2|Bacteria,1RH34@1224|Proteobacteria,2UCM1@28211|Alphaproteobacteria,4BA0F@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	protein conserved in bacteria	smrA	-	-	-	-	-	-	-	-	-	-	-	Smr
SHD2_k127_8208926_23	331869.BAL199_11346	1.081e-106	355.0	COG0524@1|root,COG0524@2|Bacteria,1MUUC@1224|Proteobacteria,2TS9D@28211|Alphaproteobacteria,4BPX1@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	G	PFAM pfkB family carbohydrate kinase	pfkB	-	2.7.1.20,2.7.1.4	ko:K00847,ko:K00856	ko00051,ko00230,ko00500,ko00520,ko01100,map00051,map00230,map00500,map00520,map01100	-	R00185,R00760,R00867,R03920	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
SHD2_k127_8208926_57	402881.Plav_3566	6.924e-32	133.0	COG2981@1|root,COG2981@2|Bacteria,1MWAA@1224|Proteobacteria,2TT6E@28211|Alphaproteobacteria,1JP4J@119043|Rhodobiaceae	28211|Alphaproteobacteria	E	Etoposide-induced protein 2.4 (EI24)	MA20_24505	-	-	ko:K06203	-	-	-	-	ko00000	-	-	-	EI24
SHD2_k127_8208926_67	1282876.BAOK01000002_gene144	0.0006003	48.0	2EHHR@1|root,33B9P@2|Bacteria,1NGHW@1224|Proteobacteria,2UJVS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_8208926_24	1380391.JIAS01000019_gene1171	3.998e-96	322.0	COG0177@1|root,COG0177@2|Bacteria,1MUYQ@1224|Proteobacteria,2TRI2@28211|Alphaproteobacteria,2JQG5@204441|Rhodospirillales	204441|Rhodospirillales	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
SHD2_k127_8208926_60	1121033.AUCF01000003_gene3457	8.65e-28	119.0	COG5488@1|root,COG5488@2|Bacteria,1NPQQ@1224|Proteobacteria,2UB81@28211|Alphaproteobacteria,2JTP1@204441|Rhodospirillales	204441|Rhodospirillales	S	Integral membrane protein (DUF2244)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2244
SHD2_k127_8208926_33	1123237.Salmuc_04051	2.311e-85	293.0	COG0350@1|root,COG2207@1|root,COG0350@2|Bacteria,COG2207@2|Bacteria,1N2YQ@1224|Proteobacteria,2TQRX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Methyltransferase	ada	-	2.1.1.63	ko:K10778	-	-	-	-	ko00000,ko01000,ko03000,ko03400	-	-	-	DNA_binding_1,HTH_18
SHD2_k127_8208926_20	439375.Oant_1330	4.724e-111	364.0	COG0289@1|root,COG0289@2|Bacteria,1MUCT@1224|Proteobacteria,2TSFJ@28211|Alphaproteobacteria,1J282@118882|Brucellaceae	28211|Alphaproteobacteria	E	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate	dapB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_C,DapB_N
SHD2_k127_8208926_64	1282876.BAOK01000001_gene987	7.514e-15	87.0	2CCBE@1|root,33P4Q@2|Bacteria,1NPK9@1224|Proteobacteria,2UV3K@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_8208926_54	1411123.JQNH01000001_gene3324	3.355e-47	175.0	COG0576@1|root,COG0576@2|Bacteria,1RH8T@1224|Proteobacteria,2U5V2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	GO:0000166,GO:0000774,GO:0003674,GO:0005488,GO:0005515,GO:0008150,GO:0017076,GO:0030234,GO:0030554,GO:0036094,GO:0050790,GO:0051082,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0097159,GO:0098772,GO:1901265,GO:1901363	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
SHD2_k127_8208926_13	402881.Plav_3579	6.035e-130	424.0	COG1420@1|root,COG1420@2|Bacteria,1MVX4@1224|Proteobacteria,2TRUF@28211|Alphaproteobacteria,1JNDZ@119043|Rhodobiaceae	28211|Alphaproteobacteria	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	-	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HrcA,HrcA_DNA-bdg
SHD2_k127_8208926_21	402881.Plav_3580	1.013e-109	359.0	COG0689@1|root,COG0689@2|Bacteria,1MVFZ@1224|Proteobacteria,2TRMC@28211|Alphaproteobacteria,1JNME@119043|Rhodobiaceae	28211|Alphaproteobacteria	J	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates	rph	GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575	2.7.7.56	ko:K00989	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNase_PH,RNase_PH_C
SHD2_k127_8208926_43	1280954.HPO_14831	1.716e-70	245.0	COG0127@1|root,COG0127@2|Bacteria,1MUK5@1224|Proteobacteria,2TV4B@28211|Alphaproteobacteria,43XEJ@69657|Hyphomonadaceae	28211|Alphaproteobacteria	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	rdgB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
SHD2_k127_8208926_10	1370122.JHXQ01000021_gene2247	3.976e-136	446.0	COG0635@1|root,COG0635@2|Bacteria,1MU76@1224|Proteobacteria,2TT63@28211|Alphaproteobacteria,4B7X1@82115|Rhizobiaceae	28211|Alphaproteobacteria	H	Involved in the biosynthesis of porphyrin-containing compound	hemN	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
SHD2_k127_8208926_35	1282876.BAOK01000002_gene115	4.384e-83	291.0	COG0683@1|root,COG0683@2|Bacteria,1QURG@1224|Proteobacteria,2TS62@28211|Alphaproteobacteria,4BQ8V@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Periplasmic binding protein	MA20_24635	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
SHD2_k127_8208926_26	1280954.HPO_01160	2.081e-94	321.0	COG0313@1|root,COG0313@2|Bacteria,1MU0E@1224|Proteobacteria,2TR14@28211|Alphaproteobacteria,43X1K@69657|Hyphomonadaceae	28211|Alphaproteobacteria	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	-	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
SHD2_k127_8208926_58	1280941.HY2_05420	2.993e-31	127.0	COG0792@1|root,COG0792@2|Bacteria,1N6VN@1224|Proteobacteria,2UFTM@28211|Alphaproteobacteria,43YAQ@69657|Hyphomonadaceae	28211|Alphaproteobacteria	L	Belongs to the UPF0102 family	MA20_24645	-	-	ko:K07460	-	-	-	-	ko00000	-	-	-	UPF0102
SHD2_k127_8208926_52	1207063.P24_02471	2.482e-50	188.0	COG2912@1|root,COG2912@2|Bacteria,1MVJQ@1224|Proteobacteria,2U64D@28211|Alphaproteobacteria,2JRS0@204441|Rhodospirillales	204441|Rhodospirillales	S	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	TPR_9,Transglut_core2
SHD2_k127_8208926_5	1244869.H261_08298	6.564e-152	484.0	COG0189@1|root,COG0189@2|Bacteria,1MVUA@1224|Proteobacteria,2TQNE@28211|Alphaproteobacteria,2JPV4@204441|Rhodospirillales	204441|Rhodospirillales	H	Belongs to the prokaryotic GSH synthase family	gshB	-	6.3.2.3	ko:K01920	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00497,R10994	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	GSH-S_ATP,GSH-S_N
SHD2_k127_8208926_39	32049.SYNPCC7002_A2717	1.505e-78	268.0	COG1741@1|root,COG1741@2|Bacteria,1G0UH@1117|Cyanobacteria,1GYC7@1129|Synechococcus	1117|Cyanobacteria	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin
SHD2_k127_8208926_30	670292.JH26_22275	1.432e-89	304.0	COG3176@1|root,COG3176@2|Bacteria,1MWIM@1224|Proteobacteria,2TUVA@28211|Alphaproteobacteria,1JR6C@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Acetyltransferase (GNAT) domain	olsB	-	2.3.2.30	ko:K22310	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_5
SHD2_k127_8208926_7	1292034.OR37_00795	6.7e-150	489.0	COG2211@1|root,COG2211@2|Bacteria,1QTSE@1224|Proteobacteria,2TWGV@28211|Alphaproteobacteria,2KEXE@204458|Caulobacterales	204458|Caulobacterales	G	Major facilitator superfamily	-	-	-	ko:K08218	ko01501,map01501	M00628	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.25	-	-	Acatn,MFS_1
SHD2_k127_8208926_12	1333998.M2A_0282	9.09e-131	444.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2U4KP@28211|Alphaproteobacteria,4BR8T@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Hpt,MASE1,MHYT,PAS,PAS_3,PAS_4,PAS_7,Response_reg
SHD2_k127_8208926_11	395965.Msil_0838	1.095e-134	436.0	COG0573@1|root,COG0573@2|Bacteria,1MVKP@1224|Proteobacteria,2TQU1@28211|Alphaproteobacteria,3NAV9@45404|Beijerinckiaceae	28211|Alphaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	pstC	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
SHD2_k127_8208926_19	670307.HYPDE_24013	3.563e-111	365.0	COG0581@1|root,COG0581@2|Bacteria,1MUWB@1224|Proteobacteria,2TQYQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	phosphate transport system permease	pstA	GO:0003674,GO:0005215,GO:0005315,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0010921,GO:0015291,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0019220,GO:0019222,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0031323,GO:0033554,GO:0034220,GO:0035303,GO:0035435,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051174,GO:0051179,GO:0051234,GO:0051336,GO:0051716,GO:0055085,GO:0065007,GO:0065009,GO:0071944,GO:0098656,GO:0098660,GO:0098661	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
SHD2_k127_8208926_14	107636.JQNK01000009_gene3284	8.083e-128	414.0	COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,2TQX9@28211|Alphaproteobacteria,36X8D@31993|Methylocystaceae	28211|Alphaproteobacteria	P	ABC transporter	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
SHD2_k127_8208926_4	395019.Bmul_0940	1.06e-196	627.0	COG0591@1|root,COG0591@2|Bacteria,1MWX6@1224|Proteobacteria,2VM1H@28216|Betaproteobacteria,1K154@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
SHD2_k127_8208926_62	189753.AXAS01000001_gene3872	1.707e-15	79.0	2EGF3@1|root,33A73@2|Bacteria,1N8EG@1224|Proteobacteria,2VGNY@28211|Alphaproteobacteria,3K1N5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF3311)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3311
SHD2_k127_8208926_63	666685.R2APBS1_2165	3.721e-15	83.0	2EJ52@1|root,33CW9@2|Bacteria,1PD05@1224|Proteobacteria,1SY6A@1236|Gammaproteobacteria,1X79D@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_8208926_32	1382303.JPOM01000001_gene1483	1.142e-86	307.0	COG3746@1|root,COG3746@2|Bacteria,1RA39@1224|Proteobacteria,2U9KD@28211|Alphaproteobacteria,2KFTY@204458|Caulobacterales	204458|Caulobacterales	P	PFAM Phosphate-selective porin O and P	-	-	-	ko:K07221	-	-	-	-	ko00000,ko02000	1.B.5.1	-	-	Porin_O_P
SHD2_k127_8208926_44	1381123.AYOD01000035_gene3695	2.858e-70	247.0	COG0725@1|root,COG0725@2|Bacteria,1MVNA@1224|Proteobacteria,2U5B1@28211|Alphaproteobacteria,43ICA@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	Molybdenum ABC transporter	modA	GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015098,GO:0015103,GO:0015318,GO:0015399,GO:0015405,GO:0015412,GO:0015689,GO:0015698,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0030151,GO:0030288,GO:0030313,GO:0030973,GO:0031975,GO:0034220,GO:0042597,GO:0042623,GO:0042626,GO:0043167,GO:0043168,GO:0043169,GO:0043225,GO:0043492,GO:0044464,GO:0046872,GO:0046914,GO:0051179,GO:0051234,GO:0055085,GO:0098656,GO:0099133,GO:1901359	-	ko:K02020	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	SBP_bac_11
SHD2_k127_8208926_65	903818.KI912268_gene1425	5.997e-07	59.0	COG4191@1|root,COG4191@2|Bacteria,3Y2IQ@57723|Acidobacteria	57723|Acidobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg
SHD2_k127_8208926_48	269796.Rru_A3562	3.226e-54	194.0	28HKY@1|root,2Z7VN@2|Bacteria,1R79H@1224|Proteobacteria,2TUPE@28211|Alphaproteobacteria,2JPVZ@204441|Rhodospirillales	204441|Rhodospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_8208926_56	1287116.X734_33030	2.699e-40	161.0	COG1961@1|root,COG1961@2|Bacteria,1N6DV@1224|Proteobacteria,2TVBV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Recombinase	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
SHD2_k127_826958_0	1333998.M2A_1363	1.618e-275	867.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,2TS2B@28211|Alphaproteobacteria,4BP64@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	L	UvrD-like helicase C-terminal domain	uvrD	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
SHD2_k127_826958_12	1209984.BN978_02884	6.79e-49	177.0	2D8VC@1|root,32TS1@2|Bacteria,2IMXY@201174|Actinobacteria,23A2A@1762|Mycobacteriaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_826958_10	316057.RPD_3608	1.342e-54	201.0	COG1024@1|root,COG1024@2|Bacteria,1MXHV@1224|Proteobacteria,2TTEG@28211|Alphaproteobacteria,3JT1F@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	MA20_06735	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
SHD2_k127_826958_9	1333998.M2A_1364	1.705e-65	238.0	COG2264@1|root,COG2264@2|Bacteria,1MUPC@1224|Proteobacteria,2TTP3@28211|Alphaproteobacteria,4BQKD@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	J	Ribosomal protein L11 methyltransferase	prmA	-	-	ko:K02687	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PrmA
SHD2_k127_826958_2	402881.Plav_2434	6.808e-251	789.0	COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,2TQXN@28211|Alphaproteobacteria,1JNKT@119043|Rhodobiaceae	28211|Alphaproteobacteria	E	Creatinase/Prolidase N-terminal domain	pepP	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Creatinase_N_2,Peptidase_M24,Peptidase_M24_C
SHD2_k127_826958_14	314254.OA2633_13225	4.272e-10	63.0	COG0627@1|root,COG0627@2|Bacteria,1QIRQ@1224|Proteobacteria,2TUU5@28211|Alphaproteobacteria,43Z22@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
SHD2_k127_826958_6	420324.KI911961_gene1857	2.106e-130	422.0	COG0627@1|root,COG0627@2|Bacteria,1QIRQ@1224|Proteobacteria,2TUU5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
SHD2_k127_826958_11	234267.Acid_3542	1.304e-49	178.0	COG0073@1|root,COG0073@2|Bacteria	2|Bacteria	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10,6.1.1.20,6.1.1.6	ko:K01874,ko:K01890,ko:K04566,ko:K06878	ko00450,ko00970,map00450,map00970	M00359,M00360	R03658,R03659,R03660,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,B5,tRNA-synt_1f,tRNA-synt_1g,tRNA_bind
SHD2_k127_826958_1	1282876.BAOK01000001_gene1372	7.669e-267	841.0	COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,2TRHK@28211|Alphaproteobacteria,4BPM0@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2
SHD2_k127_826958_5	1207063.P24_17710	3.969e-141	469.0	COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,2TREW@28211|Alphaproteobacteria,2JQMN@204441|Rhodospirillales	204441|Rhodospirillales	L	May be involved in recombinational repair of damaged DNA	recN	-	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	SMC_N
SHD2_k127_826958_7	1282876.BAOK01000001_gene1370	3.707e-95	319.0	COG4105@1|root,COG4105@2|Bacteria,1MVS5@1224|Proteobacteria,2TRZ5@28211|Alphaproteobacteria,4BPZV@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamD	-	-	ko:K05807	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	YfiO
SHD2_k127_826958_8	414684.RC1_0605	1.482e-73	257.0	COG0774@1|root,COG0774@2|Bacteria,1MV6T@1224|Proteobacteria,2TUHH@28211|Alphaproteobacteria,2JPDC@204441|Rhodospirillales	204441|Rhodospirillales	M	Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis	lpxC	-	3.5.1.108	ko:K02535	ko00540,ko01100,map00540,map01100	M00060	R04587	RC00166,RC00300	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxC
SHD2_k127_826958_3	366602.Caul_3420	9.896e-158	514.0	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,2TV11@28211|Alphaproteobacteria,2KEYK@204458|Caulobacterales	204458|Caulobacterales	J	PFAM Amidase	-	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
SHD2_k127_826958_4	1122135.KB893146_gene1595	3.925e-153	499.0	COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,2TS1Q@28211|Alphaproteobacteria	28211|Alphaproteobacteria	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
SHD2_k127_826958_13	1316936.K678_02705	1.644e-46	174.0	COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,2TQZB@28211|Alphaproteobacteria,2JQIH@204441|Rhodospirillales	204441|Rhodospirillales	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
SHD2_k127_858541_67	1500259.JQLD01000021_gene2191	3.425e-32	140.0	2CPI3@1|root,32SJ7@2|Bacteria,1N1IR@1224|Proteobacteria,2UBVS@28211|Alphaproteobacteria,4B87Y@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF992)	-	-	-	-	-	-	-	-	-	-	-	-	DUF992
SHD2_k127_858541_30	314278.NB231_14061	1.843e-111	367.0	COG3483@1|root,COG3483@2|Bacteria,1MW68@1224|Proteobacteria,1RXYM@1236|Gammaproteobacteria,1WZ7I@135613|Chromatiales	135613|Chromatiales	E	Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety	kynA	-	1.13.11.11	ko:K00453	ko00380,ko01100,map00380,map01100	M00038	R00678	RC00356	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_dioxygenase
SHD2_k127_858541_9	644801.Psest_3829	9.161e-161	515.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,1RNB5@1236|Gammaproteobacteria,1Z0SH@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	C	acyl-CoA transferases carnitine dehydratase	coaT	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
SHD2_k127_858541_10	864069.MicloDRAFT_00018350	1.102e-156	501.0	COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,2TSRD@28211|Alphaproteobacteria,1JRBW@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
SHD2_k127_858541_32	1510531.JQJJ01000010_gene1856	2.894e-109	360.0	COG2301@1|root,COG2301@2|Bacteria,1MW0A@1224|Proteobacteria,2TTC0@28211|Alphaproteobacteria,3JR0H@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Belongs to the HpcH HpaI aldolase family	citE	-	3.1.2.30,4.1.3.34	ko:K01644,ko:K14451	ko00630,ko01120,ko01200,ko02020,map00630,map01120,map01200,map02020	M00373	R00362,R10612	RC00004,RC00014,RC00067,RC01118	ko00000,ko00001,ko00002,ko01000	-	-	-	HpcH_HpaI
SHD2_k127_858541_12	438753.AZC_3739	6.49e-153	492.0	COG2030@1|root,COG2030@2|Bacteria,1MW4N@1224|Proteobacteria,2TQQ2@28211|Alphaproteobacteria,3F0DZ@335928|Xanthobacteraceae	28211|Alphaproteobacteria	I	MaoC like domain	mch	GO:0003674,GO:0003824,GO:0006082,GO:0006083,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016829,GO:0016830,GO:0016833,GO:0016999,GO:0017001,GO:0017144,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0045733,GO:0046395,GO:0071704,GO:0072329,GO:1901575	4.2.1.148	ko:K14449	ko00630,ko00660,ko00720,ko01120,ko01200,map00630,map00660,map00720,map01120,map01200	M00373,M00376,M00740	R05076	RC01984	ko00000,ko00001,ko00002,ko01000	-	-	-	MaoC_dehydrat_N,MaoC_dehydratas
SHD2_k127_858541_24	402881.Plav_1448	7.553e-122	402.0	COG1485@1|root,COG1485@2|Bacteria,1MUUW@1224|Proteobacteria,2TRG1@28211|Alphaproteobacteria,1JNHZ@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	AFG1-like ATPase	zapE	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0006091,GO:0006119,GO:0006123,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006996,GO:0007005,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009060,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016043,GO:0016310,GO:0017144,GO:0019538,GO:0019637,GO:0019646,GO:0019693,GO:0022900,GO:0022904,GO:0030163,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0034641,GO:0035694,GO:0042773,GO:0042775,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0071840,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901565,GO:1901575	-	ko:K06916	-	-	-	-	ko00000,ko03036	-	-	-	AFG1_ATPase
SHD2_k127_858541_14	402881.Plav_1308	1.155e-146	475.0	COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,2TRZU@28211|Alphaproteobacteria,1JNP1@119043|Rhodobiaceae	28211|Alphaproteobacteria	CH	FAD binding domain	ubiH	GO:0003674,GO:0003824,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016491,GO:0019168,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901576,GO:1901661,GO:1901663	-	ko:K03185	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04989,R08773	RC02670	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_3
SHD2_k127_858541_50	1411123.JQNH01000001_gene3410	7.978e-54	190.0	COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,2U952@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Belongs to the P(II) protein family	glnK	-	-	ko:K04751,ko:K04752	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
SHD2_k127_858541_8	1205680.CAKO01000040_gene861	5.936e-170	544.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,2TT2J@28211|Alphaproteobacteria,2JPX1@204441|Rhodospirillales	204441|Rhodospirillales	U	Ammonium transporter	amtB	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
SHD2_k127_858541_21	402881.Plav_1301	8.521e-130	425.0	COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,2TQVM@28211|Alphaproteobacteria,1JPPR@119043|Rhodobiaceae	28211|Alphaproteobacteria	E	Aminotransferase class I and II	dapL	-	2.6.1.17	ko:K14261,ko:K14267	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R04475	RC00006	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
SHD2_k127_858541_2	1042326.AZNV01000001_gene5526	2.486e-247	788.0	COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,2TR48@28211|Alphaproteobacteria,4B9EM@82115|Rhizobiaceae	28211|Alphaproteobacteria	D	DNA segregation ATPase FtsK SpoIIIE and related proteins	ftsK	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
SHD2_k127_858541_69	1161401.ASJA01000008_gene1589	1.764e-30	126.0	COG3428@1|root,COG3428@2|Bacteria,1N9PB@1224|Proteobacteria,2TUD0@28211|Alphaproteobacteria,43Y8C@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	Bacterial PH domain	-	-	-	-	-	-	-	-	-	-	-	-	bPH_2
SHD2_k127_858541_73	717785.HYPMC_1633	5.303e-28	121.0	COG3474@1|root,COG3474@2|Bacteria,1MZGS@1224|Proteobacteria,2UCUT@28211|Alphaproteobacteria,3N77C@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Cytochrome c2	cycA	GO:0005575,GO:0005623,GO:0042597,GO:0044464	-	ko:K08738	ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	3.D.4.6	-	-	Cytochrom_C
SHD2_k127_858541_25	744980.TRICHSKD4_2130	1.515e-121	394.0	COG2086@1|root,COG2086@2|Bacteria,1MVH6@1224|Proteobacteria,2TR4J@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Electron transfer flavoprotein	etfB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016491,GO:0022900,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0055114	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
SHD2_k127_858541_17	402881.Plav_1607	5.113e-137	443.0	COG2025@1|root,COG2025@2|Bacteria,1MUFI@1224|Proteobacteria,2TR10@28211|Alphaproteobacteria,1JN8H@119043|Rhodobiaceae	28211|Alphaproteobacteria	C	Electron transfer flavoprotein domain	etfA	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006091,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009055,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0019395,GO:0019752,GO:0022900,GO:0030258,GO:0032787,GO:0033539,GO:0034440,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071704,GO:0072329,GO:0097159,GO:1901265,GO:1901363,GO:1901575	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
SHD2_k127_858541_20	1120792.JAFV01000001_gene3039	4.433e-132	427.0	COG1250@1|root,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2TR8E@28211|Alphaproteobacteria,36X73@31993|Methylocystaceae	28211|Alphaproteobacteria	I	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	hbdA	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
SHD2_k127_858541_49	402881.Plav_1604	2.293e-58	213.0	COG2227@1|root,COG2227@2|Bacteria,1R67Q@1224|Proteobacteria,2U5G8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
SHD2_k127_858541_35	1028800.RG540_CH39100	5.165e-104	342.0	COG4312@1|root,COG4312@2|Bacteria,1NAXN@1224|Proteobacteria,2U16Z@28211|Alphaproteobacteria,4BDVS@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Bacterial protein of unknown function (DUF899)	-	-	-	-	-	-	-	-	-	-	-	-	DUF899
SHD2_k127_858541_33	1278073.MYSTI_02175	5.855e-107	363.0	COG4977@1|root,COG4977@2|Bacteria,1MUDK@1224|Proteobacteria,42U64@68525|delta/epsilon subdivisions	1224|Proteobacteria	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI,HTH_18
SHD2_k127_858541_66	450851.PHZ_c0831	4.562e-34	148.0	COG4977@1|root,COG4977@2|Bacteria,1PFG6@1224|Proteobacteria,2V7GC@28211|Alphaproteobacteria,2KJ6G@204458|Caulobacterales	204458|Caulobacterales	K	DJ-1/PfpI family	-	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI
SHD2_k127_858541_31	402881.Plav_0615	1.189e-110	370.0	COG0673@1|root,COG0673@2|Bacteria,1QSNV@1224|Proteobacteria,2TRYY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
SHD2_k127_858541_71	414684.RC1_4104	2.394e-30	130.0	COG0526@1|root,COG0526@2|Bacteria,1MZ5J@1224|Proteobacteria,2TR0C@28211|Alphaproteobacteria,2JT90@204441|Rhodospirillales	204441|Rhodospirillales	CO	COG0526 Thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
SHD2_k127_858541_4	266835.14023775	1.462e-191	608.0	COG0165@1|root,COG0165@2|Bacteria,1MUTU@1224|Proteobacteria,2TR4H@28211|Alphaproteobacteria,43HG4@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	argininosuccinate lyase	argH	GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
SHD2_k127_858541_7	1125973.JNLC01000011_gene488	4.554e-172	550.0	COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,2TQPB@28211|Alphaproteobacteria,3JU3D@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008836,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
SHD2_k127_858541_22	402881.Plav_1599	3.474e-129	442.0	COG1511@1|root,COG1511@2|Bacteria,1QY7Q@1224|Proteobacteria,2TXIQ@28211|Alphaproteobacteria,1JQNN@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DUF4175)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4175
SHD2_k127_858541_68	1042326.AZNV01000040_gene575	7.76e-31	128.0	COG0634@1|root,COG0634@2|Bacteria,1NRT8@1224|Proteobacteria,2TTN7@28211|Alphaproteobacteria,4B7JN@82115|Rhizobiaceae	28211|Alphaproteobacteria	F	Belongs to the purine pyrimidine phosphoribosyltransferase family	hpt	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
SHD2_k127_858541_60	402881.Plav_1596	6.299e-44	169.0	2E521@1|root,32ZVA@2|Bacteria,1N9PP@1224|Proteobacteria,2UG1E@28211|Alphaproteobacteria,1JQ99@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	zinc-ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3426,zinc_ribbon_4
SHD2_k127_858541_37	1282876.BAOK01000002_gene604	3.585e-97	322.0	COG2884@1|root,COG2884@2|Bacteria,1MVQ4@1224|Proteobacteria,2TS9Y@28211|Alphaproteobacteria,4BQ1E@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	D	ABC transporter	ftsE	-	-	ko:K09812	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	ABC_tran
SHD2_k127_858541_63	1207063.P24_06561	4.86e-40	160.0	COG2177@1|root,COG2177@2|Bacteria,1MXKQ@1224|Proteobacteria,2TSNT@28211|Alphaproteobacteria,2JS4N@204441|Rhodospirillales	204441|Rhodospirillales	D	Cell division protein	-	-	-	ko:K09811	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	-
SHD2_k127_858541_64	1411123.JQNH01000001_gene3562	5.864e-40	155.0	COG1434@1|root,COG1434@2|Bacteria,1RHMV@1224|Proteobacteria,2U957@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	DUF218 domain	MA20_20455	-	-	-	-	-	-	-	-	-	-	-	DUF218
SHD2_k127_858541_47	402881.Plav_1592	1.215e-68	241.0	COG0204@1|root,COG0204@2|Bacteria,1MY51@1224|Proteobacteria,2TT3P@28211|Alphaproteobacteria,1JNX9@119043|Rhodobiaceae	28211|Alphaproteobacteria	I	Phosphate acyltransferases	plsC	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
SHD2_k127_858541_0	402881.Plav_1591	0.0	1044.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2TS19@28211|Alphaproteobacteria,1JNRV@119043|Rhodobiaceae	28211|Alphaproteobacteria	F	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides	nrdZ	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_lgC,Ribonuc_red_lgN
SHD2_k127_858541_29	402881.Plav_1587	2.879e-113	378.0	COG3214@1|root,COG3214@2|Bacteria,1N40B@1224|Proteobacteria,2TT7U@28211|Alphaproteobacteria,1JQ4F@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Winged helix DNA-binding domain	-	-	-	ko:K09927	-	-	-	-	ko00000	-	-	-	HTH_42
SHD2_k127_858541_81	460265.Mnod_4444	1.813e-09	69.0	COG4093@1|root,COG4093@2|Bacteria,1MXJA@1224|Proteobacteria,2TRH7@28211|Alphaproteobacteria,1JTC3@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2125)	MA20_20440	-	-	-	-	-	-	-	-	-	-	-	DUF2125
SHD2_k127_858541_78	1288494.EBAPG3_2080	2.486e-23	105.0	COG3360@1|root,COG3360@2|Bacteria,1PW6C@1224|Proteobacteria,2VXDE@28216|Betaproteobacteria,373H6@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Dodecin	-	-	-	ko:K09165	-	-	-	-	ko00000	-	-	-	Dodecin
SHD2_k127_858541_18	1333998.M2A_0935	5.645e-134	435.0	COG0287@1|root,COG0287@2|Bacteria,1QTZA@1224|Proteobacteria,2TS12@28211|Alphaproteobacteria,4BPRS@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Prephenate dehydrogenase	tyrC	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008977,GO:0009058,GO:0009072,GO:0009073,GO:0009095,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019438,GO:0019752,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046983,GO:0047794,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0070403,GO:0071704,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.3.1.12,1.3.1.43	ko:K00210,ko:K00220,ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025,M00040	R00732,R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	PDH
SHD2_k127_858541_13	402881.Plav_1583	7.311e-148	477.0	COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,2TQPN@28211|Alphaproteobacteria,1JNP6@119043|Rhodobiaceae	28211|Alphaproteobacteria	E	DegT/DnrJ/EryC1/StrS aminotransferase family	hisC	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
SHD2_k127_858541_61	1380394.JADL01000001_gene2864	8.375e-44	170.0	COG1605@1|root,COG1605@2|Bacteria,1MWTP@1224|Proteobacteria,2TV3Z@28211|Alphaproteobacteria,2JRWA@204441|Rhodospirillales	204441|Rhodospirillales	E	chorismate mutase	-	-	-	-	-	-	-	-	-	-	-	-	CM_2
SHD2_k127_858541_6	402881.Plav_1581	1.531e-187	593.0	COG2021@1|root,COG2021@2|Bacteria,1MVJV@1224|Proteobacteria,2TQYA@28211|Alphaproteobacteria,1JNHV@119043|Rhodobiaceae	28211|Alphaproteobacteria	E	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine	metXA	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004414,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009092,GO:0009987,GO:0016053,GO:0016407,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.31	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	-	R01776	RC00004,RC00041	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
SHD2_k127_858541_44	136993.KB900626_gene3341	3.382e-72	256.0	COG0500@1|root,COG2226@2|Bacteria,1MVSY@1224|Proteobacteria,2TTNQ@28211|Alphaproteobacteria,36XCV@31993|Methylocystaceae	28211|Alphaproteobacteria	Q	Methionine biosynthesis protein MetW	metW	-	-	-	-	-	-	-	-	-	-	-	MetW
SHD2_k127_858541_46	402881.Plav_1579	5.256e-70	248.0	COG0500@1|root,COG2226@2|Bacteria,1NA7K@1224|Proteobacteria,2TT7T@28211|Alphaproteobacteria,1JP16@119043|Rhodobiaceae	28211|Alphaproteobacteria	Q	Methyltransferase domain	MA20_39625	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
SHD2_k127_858541_39	402881.Plav_1578	6.051e-95	318.0	COG0491@1|root,COG0491@2|Bacteria,1MU8Q@1224|Proteobacteria,2TSVS@28211|Alphaproteobacteria,1JNV9@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	gloB	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	HAGH_C,Lactamase_B
SHD2_k127_858541_54	384765.SIAM614_25846	8.097e-49	183.0	COG0637@1|root,COG0637@2|Bacteria,1NSPA@1224|Proteobacteria,2U0W3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	hydrolase	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
SHD2_k127_858541_52	269796.Rru_A0661	1.942e-50	190.0	COG1272@1|root,COG1272@2|Bacteria,1PGRH@1224|Proteobacteria,2TSXY@28211|Alphaproteobacteria,2JT6N@204441|Rhodospirillales	204441|Rhodospirillales	S	Haemolysin-III related	-	-	-	ko:K11068	-	-	-	-	ko00000,ko02042	-	-	-	HlyIII
SHD2_k127_858541_65	1121015.N789_03855	7.367e-36	141.0	COG3686@1|root,COG3686@2|Bacteria,1N00R@1224|Proteobacteria,1S7JA@1236|Gammaproteobacteria,1X7NQ@135614|Xanthomonadales	135614|Xanthomonadales	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	MAPEG
SHD2_k127_858541_45	1219049.SP5_017_00060	4.749e-70	242.0	COG1573@1|root,COG1573@2|Bacteria,1MW8T@1224|Proteobacteria,2TSAR@28211|Alphaproteobacteria,2K0Y7@204457|Sphingomonadales	204457|Sphingomonadales	L	Uracil-DNA glycosylase	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DUF4130,UDG
SHD2_k127_858541_72	110319.CF8_3537	7.447e-30	123.0	COG4226@1|root,COG4226@2|Bacteria,2IKXB@201174|Actinobacteria,4DS17@85009|Propionibacteriales	201174|Actinobacteria	S	protein encoded in hypervariable junctions of pilus gene clusters	-	-	-	-	-	-	-	-	-	-	-	-	HicB,RHH_1
SHD2_k127_858541_70	1223545.GS4_07_00190	2.114e-30	134.0	COG3595@1|root,COG3595@2|Bacteria,2GJZC@201174|Actinobacteria,4GER0@85026|Gordoniaceae	201174|Actinobacteria	S	Putative adhesin	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097
SHD2_k127_858541_1	1144310.PMI07_001383	1.237e-264	839.0	COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,2TS6C@28211|Alphaproteobacteria,4B9A5@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	rpoD	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
SHD2_k127_858541_15	1411123.JQNH01000001_gene2438	1.838e-144	480.0	COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,2TRU2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,Toprim_4,Toprim_N,zf-CHC2
SHD2_k127_858541_58	1197906.CAJQ02000006_gene2899	4.299e-47	173.0	COG1610@1|root,COG1610@2|Bacteria,1RGZS@1224|Proteobacteria,2U7DJ@28211|Alphaproteobacteria,3JYDG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Yqey-like protein	MA20_04985	-	-	ko:K09117	-	-	-	-	ko00000	-	-	-	YqeY
SHD2_k127_858541_11	754035.Mesau_02324	8.424e-156	514.0	COG0505@1|root,COG0505@2|Bacteria,1MUB9@1224|Proteobacteria,2TR3W@28211|Alphaproteobacteria,43HWP@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	F	Belongs to the CarA family	carA	GO:0000050,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005951,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0019627,GO:0019752,GO:0032991,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
SHD2_k127_858541_77	1121939.L861_24065	2.559e-24	108.0	COG0662@1|root,COG0662@2|Bacteria,1N71F@1224|Proteobacteria	1224|Proteobacteria	G	Cupin 2, conserved barrel	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
SHD2_k127_858541_57	426117.M446_4788	5.879e-48	177.0	COG1595@1|root,COG1595@2|Bacteria,1NRNT@1224|Proteobacteria,2TT5K@28211|Alphaproteobacteria,1JVJ8@119045|Methylobacteriaceae	28211|Alphaproteobacteria	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
SHD2_k127_858541_53	1366050.N234_03540	2.696e-49	186.0	COG5662@1|root,COG5662@2|Bacteria,1MV95@1224|Proteobacteria,2VSSM@28216|Betaproteobacteria,1K2HQ@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
SHD2_k127_858541_16	1472716.KBK24_0112180	3.597e-140	451.0	COG1409@1|root,COG1409@2|Bacteria,1MUQJ@1224|Proteobacteria,2VJNP@28216|Betaproteobacteria,1K36Q@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Metallophosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
SHD2_k127_858541_76	1121127.JAFA01000034_gene4474	9.596e-25	107.0	COG3794@1|root,COG3794@2|Bacteria,1NKZ5@1224|Proteobacteria,2VW1T@28216|Betaproteobacteria,1K8BA@119060|Burkholderiaceae	28216|Betaproteobacteria	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cupredoxin_1
SHD2_k127_858541_62	755732.Fluta_1519	3.818e-43	165.0	COG0346@1|root,COG0346@2|Bacteria,4NQ3F@976|Bacteroidetes,1I2U9@117743|Flavobacteriia	976|Bacteroidetes	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
SHD2_k127_858541_38	1463926.JOCA01000005_gene3293	9.882e-97	325.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
SHD2_k127_858541_75	648757.Rvan_2158	1.44e-25	109.0	COG3811@1|root,COG3811@2|Bacteria,1N7N0@1224|Proteobacteria,2UF95@28211|Alphaproteobacteria,3N76K@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Putative toxin of bacterial toxin-antitoxin pair	-	-	-	ko:K09982	-	-	-	-	ko00000	-	-	-	YjhX_toxin
SHD2_k127_858541_74	1320556.AVBP01000019_gene1297	9.457e-27	119.0	2E21J@1|root,32X9B@2|Bacteria,1RGIB@1224|Proteobacteria,2UC7C@28211|Alphaproteobacteria,43K21@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DUF4893)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4893
SHD2_k127_858541_23	1333998.M2A_0321	5.866e-123	403.0	COG0623@1|root,COG0623@2|Bacteria,1MV05@1224|Proteobacteria,2TSU4@28211|Alphaproteobacteria,4BPR7@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	I	Enoyl-(Acyl carrier protein) reductase	fabI	GO:0003674,GO:0003824,GO:0004312,GO:0004318,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0022607,GO:0030497,GO:0032787,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0072330,GO:1901576	1.3.1.10,1.3.1.9	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
SHD2_k127_858541_3	1333998.M2A_0322	3.813e-199	628.0	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,2TQYV@28211|Alphaproteobacteria,4BPJ8@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	IQ	Belongs to the beta-ketoacyl-ACP synthases family	fabB	GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.3.1.41	ko:K00647	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
SHD2_k127_858541_43	1328313.DS2_16599	2.474e-74	254.0	COG0764@1|root,COG0764@2|Bacteria,1MWV8@1224|Proteobacteria,1RP6W@1236|Gammaproteobacteria,4657R@72275|Alteromonadaceae	1236|Gammaproteobacteria	I	Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length	fabA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0008693,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016860,GO:0016863,GO:0019171,GO:0019752,GO:0032787,GO:0034017,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0047451,GO:0071704,GO:0072330,GO:1901576	4.2.1.59,5.3.3.14	ko:K01716	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00083	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07639	RC00831,RC01078,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	iAF1260.b0954,iB21_1397.B21_00965,iBWG_1329.BWG_0806,iE2348C_1286.E2348C_0940,iEC042_1314.EC042_1039,iECBD_1354.ECBD_2641,iECB_1328.ECB_00958,iECDH10B_1368.ECDH10B_1024,iECD_1391.ECD_00958,iECED1_1282.ECED1_0977,iECH74115_1262.ECH74115_1118,iECIAI1_1343.ECIAI1_0995,iECIAI39_1322.ECIAI39_2193,iECNA114_1301.ECNA114_1032,iECO103_1326.ECO103_1000,iECO111_1330.ECO111_1022,iECO26_1355.ECO26_1081,iECOK1_1307.ECOK1_1013,iECS88_1305.ECS88_0975,iECSF_1327.ECSF_0868,iECSP_1301.ECSP_1060,iECUMN_1333.ECUMN_1143,iECW_1372.ECW_m1064,iECs_1301.ECs1038,iEKO11_1354.EKO11_2876,iETEC_1333.ETEC_1024,iEcE24377_1341.EcE24377A_1068,iEcHS_1320.EcHS_A1063,iEcSMS35_1347.EcSMS35_2166,iEcolC_1368.EcolC_2642,iG2583_1286.G2583_1189,iJO1366.b0954,iJR904.b0954,iLF82_1304.LF82_0604,iSBO_1134.SBO_2277,iSDY_1059.SDY_0927,iSF_1195.SF0954,iSSON_1240.SSON_0958,iSbBS512_1146.SbBS512_E2362,iUMNK88_1353.UMNK88_1108,iWFL_1372.ECW_m1064,iY75_1357.Y75_RS04955,iZ_1308.Z1304,ic_1306.c1090	FabA
SHD2_k127_858541_56	1380394.JADL01000028_gene4420	1.328e-48	178.0	COG0735@1|root,COG0735@2|Bacteria,1RH58@1224|Proteobacteria,2U75R@28211|Alphaproteobacteria,2JT3E@204441|Rhodospirillales	204441|Rhodospirillales	K	Belongs to the Fur family	-	-	-	ko:K09826	-	-	-	-	ko00000,ko03000	-	-	-	FUR
SHD2_k127_858541_42	1207063.P24_02276	6.641e-78	262.0	COG1592@1|root,COG1592@2|Bacteria,1R9WG@1224|Proteobacteria,2U5EA@28211|Alphaproteobacteria,2JRP1@204441|Rhodospirillales	204441|Rhodospirillales	C	COG1592 Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
SHD2_k127_858541_5	1333998.M2A_0326	4.718e-191	605.0	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,2U059@28211|Alphaproteobacteria,4BRVA@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Cysteine-rich domain	-	-	1.1.5.3	ko:K00113	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	CCG
SHD2_k127_858541_48	402881.Plav_3640	3.411e-61	216.0	COG0247@1|root,COG0247@2|Bacteria,1RF02@1224|Proteobacteria,2U69V@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Protein of unknown function (DUF3501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3501
SHD2_k127_858541_79	1282362.AEAC466_14280	4.219e-21	103.0	COG3212@1|root,COG3212@2|Bacteria,1NCU3@1224|Proteobacteria,2UFIF@28211|Alphaproteobacteria,2KH6K@204458|Caulobacterales	204458|Caulobacterales	S	Peptidase propeptide and YPEB domain	-	-	-	-	-	-	-	-	-	-	-	-	PepSY
SHD2_k127_858541_55	1215092.PA6_009_00750	1.052e-48	180.0	COG3812@1|root,COG3812@2|Bacteria,1RGUV@1224|Proteobacteria,1S6J5@1236|Gammaproteobacteria,1YGB9@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	Domain of unknown function (DUF1993)	-	-	-	ko:K09983	-	-	-	-	ko00000	-	-	-	DUF1993
SHD2_k127_858541_40	196367.JNFG01000199_gene3574	9.626e-93	310.0	COG0625@1|root,COG0625@2|Bacteria,1MUN3@1224|Proteobacteria,2VHCD@28216|Betaproteobacteria,1K20D@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Belongs to the GST superfamily	-	-	2.5.1.18	ko:K00799,ko:K11209	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_3,GST_N,GST_N_3
SHD2_k127_858541_41	1040989.AWZU01000015_gene2659	1.32e-89	300.0	COG1011@1|root,COG1011@2|Bacteria,1Q69X@1224|Proteobacteria,2TTTP@28211|Alphaproteobacteria,3JTMD@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Haloacid dehalogenase-like hydrolase	MA20_23095	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
SHD2_k127_858541_19	1333998.M2A_1982	2.914e-132	428.0	COG0491@1|root,COG0491@2|Bacteria,1MX4H@1224|Proteobacteria,2TQUY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	COG0491 Zn-dependent hydrolases, including glyoxylases	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
SHD2_k127_858541_36	1121949.AQXT01000002_gene2366	3.46e-102	339.0	COG0625@1|root,COG0625@2|Bacteria,1MXJD@1224|Proteobacteria,2U5C5@28211|Alphaproteobacteria,43ZK6@69657|Hyphomonadaceae	28211|Alphaproteobacteria	O	Glutathione S-transferase, C-terminal domain	-	-	2.5.1.18	ko:K00799,ko:K03599	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000,ko03021	1.A.12.2.2,1.A.12.3.1,1.A.12.3.2	-	-	GST_C,GST_C_2,GST_N_3
SHD2_k127_858541_34	1333998.M2A_1984	3.917e-106	352.0	COG0625@1|root,COG0625@2|Bacteria,1P71B@1224|Proteobacteria,2U1A5@28211|Alphaproteobacteria,4BQAR@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	O	Glutathione S-transferase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	GST_C_2,GST_N_3
SHD2_k127_858541_80	402881.Plav_0379	4.244e-11	70.0	COG5388@1|root,COG5388@2|Bacteria,1P27X@1224|Proteobacteria,2UUNI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	PAS_5
SHD2_k127_858541_82	1380394.JADL01000004_gene5783	4.676e-06	56.0	COG5388@1|root,COG5388@2|Bacteria,1N0UI@1224|Proteobacteria,2UCZU@28211|Alphaproteobacteria,2JTNR@204441|Rhodospirillales	204441|Rhodospirillales	S	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	PAS_5
SHD2_k127_858541_28	1382306.JNIM01000001_gene2032	1.091e-113	384.0	COG2272@1|root,COG2272@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	pnbA	-	-	ko:K03929	-	-	-	-	ko00000,ko01000	-	CE10	-	COesterase
SHD2_k127_858541_59	1123267.JONN01000001_gene850	1.516e-46	179.0	COG2010@1|root,COG2010@2|Bacteria,1MXXQ@1224|Proteobacteria,2U38E@28211|Alphaproteobacteria,2KCD6@204457|Sphingomonadales	204457|Sphingomonadales	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	-
SHD2_k127_858541_26	414684.RC1_2986	5.325e-119	401.0	COG1092@1|root,COG1092@2|Bacteria,1MUGB@1224|Proteobacteria,2TUNR@28211|Alphaproteobacteria,2JPGZ@204441|Rhodospirillales	204441|Rhodospirillales	J	S-adenosylmethionine-dependent methyltransferase	-	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
SHD2_k127_858541_27	1205680.CAKO01000002_gene2250	1.286e-116	385.0	COG3158@1|root,COG3158@2|Bacteria,1MUVH@1224|Proteobacteria,2TRVJ@28211|Alphaproteobacteria,2JPFG@204441|Rhodospirillales	204441|Rhodospirillales	P	Transport of potassium into the cell	-	-	-	-	-	-	-	-	-	-	-	-	K_trans
## 3327 queries scanned
## Total time (seconds): 419.3845057487488
## Rate: 7.93 q/s