## Sat Nov 16 18:28:25 2024 ## emapper-2.1.12 ## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/bin_4635/bin/bin22/SRD_1_bin.2.fa -m mmseqs --itype genome -o SRD_1_bin.2 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/4635/SRD_1_bin.2 --cpu 28 ## #query seed_ortholog evalue score eggNOG_OGs max_annot_lvl COG_category Description Preferred_name GOs EC KEGG_ko KEGG_Pathway KEGG_Module KEGG_Reaction KEGG_rclass BRITE KEGG_TC CAZy BiGG_Reaction PFAMs SRD1_k127_1007094_6 401526.TcarDRAFT_1973 2.276e-21 97.0 COG0375@1|root,COG0375@2|Bacteria,1VEP0@1239|Firmicutes,4H581@909932|Negativicutes 909932|Negativicutes S Probably plays a role in a hydrogenase nickel cofactor insertion step hypA - - ko:K04651 - - - - ko00000,ko03110 - - - HypA SRD1_k127_1007094_3 644282.Deba_2742 5.072e-77 263.0 COG0378@1|root,COG0378@2|Bacteria,1MVBD@1224|Proteobacteria,42MMJ@68525|delta/epsilon subdivisions,2WK7X@28221|Deltaproteobacteria 28221|Deltaproteobacteria KO TIGRFAM Hydrogenase accessory protein HypB hypB - - ko:K04652 - - - - ko00000,ko03110 - - - cobW SRD1_k127_1007094_5 459495.SPLC1_S300800 6.764e-56 201.0 COG1905@1|root,COG1905@2|Bacteria,1G54V@1117|Cyanobacteria,1HAJC@1150|Oscillatoriales 1117|Cyanobacteria C PFAM Respiratory-chain NADH dehydrogenase 24 Kd subunit hoxE - 1.6.5.3 ko:K05586 ko00190,ko01100,map00190,map01100 - R11945 RC00061 ko00000,ko00001,ko01000 - - - 2Fe-2S_thioredx SRD1_k127_1007094_0 926550.CLDAP_28490 8.473e-223 705.0 COG1894@1|root,COG1894@2|Bacteria,2G5K9@200795|Chloroflexi 200795|Chloroflexi C PFAM Respiratory-chain NADH dehydrogenase domain, 51 kDa subunit hoxF - 1.6.5.3 ko:K00335,ko:K05587 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB SRD1_k127_1007094_2 41431.PCC8801_0097 6.565e-100 331.0 COG3383@1|root,COG3383@2|Bacteria,1G3GD@1117|Cyanobacteria,3KG0N@43988|Cyanothece 1117|Cyanobacteria C 4Fe-4S ferredoxin iron-sulfur binding domain protein hoxU - 1.6.5.3 ko:K05588 ko00190,ko01100,map00190,map01100 - R11945 RC00061 ko00000,ko00001,ko01000 - - - Fer2_4,Fer4,Fer4_10,Fer4_6,Fer4_9,NADH-G_4Fe-4S_3 SRD1_k127_1007094_4 326427.Cagg_2477 5.455e-56 201.0 COG1941@1|root,COG1941@2|Bacteria,2G6MH@200795|Chloroflexi,3776J@32061|Chloroflexia 32061|Chloroflexia C PFAM NADH ubiquinone oxidoreductase 20 kDa subunit - - 1.12.1.2 ko:K18007 - - - - ko00000,ko01000 - - - Oxidored_q6 SRD1_k127_1007094_1 195250.CM001776_gene592 5.088e-105 347.0 COG3259@1|root,COG3259@2|Bacteria,1G1C8@1117|Cyanobacteria,1GZB4@1129|Synechococcus 1117|Cyanobacteria C Nickel-dependent hydrogenase hoxH - 1.12.1.2 ko:K00436 - - R00700 - ko00000,ko01000 - - iJN678.hoxH NiFeSe_Hases SRD1_k127_1010688_2 517418.Ctha_0212 1.994e-127 421.0 COG2270@1|root,COG2270@2|Bacteria,1FDCC@1090|Chlorobi 1090|Chlorobi S PFAM major facilitator superfamily MFS_1 - - - ko:K06902 ko04138,map04138 - - - ko00000,ko00001,ko02000,ko04131 2.A.1.24,9.A.15.1 - - ATG22 SRD1_k127_1010688_4 518766.Rmar_0030 2.629e-48 177.0 COG0781@1|root,COG0781@2|Bacteria,4NDVR@976|Bacteroidetes,1FJJ7@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons nusB - - ko:K03625 - - - - ko00000,ko03009,ko03021 - - - NusB SRD1_k127_1010688_3 1173022.Cri9333_1995 3.508e-75 268.0 COG5263@1|root,COG5263@2|Bacteria,1G1AI@1117|Cyanobacteria,1HASA@1150|Oscillatoriales 1117|Cyanobacteria S KWG Leptospira - - - - - - - - - - - - WG_beta_rep SRD1_k127_1010688_0 316067.Geob_3238 4.398e-278 871.0 COG3408@1|root,COG3408@2|Bacteria,1MW01@1224|Proteobacteria,42NSN@68525|delta/epsilon subdivisions,2WJF7@28221|Deltaproteobacteria,43TN0@69541|Desulfuromonadales 28221|Deltaproteobacteria G Glycogen debranching enzyme N terminal - - - - - - - - - - - - GDE_C,GDE_N SRD1_k127_1010688_1 1232410.KI421416_gene2671 2.04e-261 819.0 COG0296@1|root,COG0296@2|Bacteria,1MVM7@1224|Proteobacteria,42MKI@68525|delta/epsilon subdivisions,2WM5H@28221|Deltaproteobacteria,43TX2@69541|Desulfuromonadales 28221|Deltaproteobacteria G Domain of unknown function (DUF3459) treZ-2 - 3.2.1.141 ko:K01236 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R09995,R11256 RC00049 ko00000,ko00001,ko00002,ko01000 - CBM48,GH13 - Alpha-amylase,CBM_48,DUF3459 SRD1_k127_1020154_1 518766.Rmar_1280 2.835e-70 257.0 COG1520@1|root,COG2931@1|root,COG1520@2|Bacteria,COG2931@2|Bacteria,4NKF1@976|Bacteroidetes 976|Bacteroidetes Q A domain in the BMP inhibitor chordin and in microbial proteins. - - - - - - - - - - - - CHRD,SusE SRD1_k127_1020154_0 483219.LILAB_34510 1.537e-286 897.0 COG0493@1|root,COG0543@1|root,COG0493@2|Bacteria,COG0543@2|Bacteria,1Q2ZJ@1224|Proteobacteria,438P5@68525|delta/epsilon subdivisions,2X8TH@28221|Deltaproteobacteria,2YXE6@29|Myxococcales 28221|Deltaproteobacteria CEH Pyridine nucleotide-disulphide oxidoreductase - - - - - - - - - - - - Pyr_redox_2 SRD1_k127_1028989_0 518766.Rmar_2690 5.246e-148 475.0 COG0304@1|root,COG0304@2|Bacteria,4NEKC@976|Bacteroidetes,1FIY5@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP fabF - 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt SRD1_k127_1028989_2 945713.IALB_1987 1.05e-54 203.0 COG0571@1|root,COG0571@2|Bacteria 2|Bacteria J ribonuclease III activity rnc GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 3.1.26.3 ko:K03685 ko03008,ko05205,map03008,map05205 - - - ko00000,ko00001,ko01000,ko03009,ko03019,ko03036 - - - Ribonucleas_3_3,dsrm SRD1_k127_1028989_3 234267.Acid_6492 2.118e-40 158.0 COG1832@1|root,COG1832@2|Bacteria,3Y566@57723|Acidobacteria 57723|Acidobacteria S CoA binding domain - - - ko:K06929 - - - - ko00000 - - - CoA_binding_2 SRD1_k127_1028989_1 945713.IALB_1985 6.602e-57 216.0 COG4775@1|root,COG4775@2|Bacteria 2|Bacteria M membrane organization - - - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA SRD1_k127_1092478_6 945713.IALB_1367 1.348e-35 139.0 COG0177@1|root,COG0177@2|Bacteria 2|Bacteria L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate nth - 4.2.99.18 ko:K10773 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,HhH-GPD SRD1_k127_1092478_1 945713.IALB_1376 1.023e-74 258.0 COG0035@1|root,COG0035@2|Bacteria 2|Bacteria F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate upp GO:0003674,GO:0003824,GO:0004845,GO:0004849,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016757,GO:0016763,GO:0016772,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0042802,GO:0043094,GO:0043097,GO:0043174,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.9 ko:K00761 ko00240,ko01100,map00240,map01100 - R00966 RC00063 ko00000,ko00001,ko01000 - - iAF1260.b2498,iAPECO1_1312.APECO1_4071,iB21_1397.B21_02352,iBWG_1329.BWG_2262,iE2348C_1286.E2348C_2723,iEC042_1314.EC042_2699,iEC55989_1330.EC55989_2783,iECABU_c1320.ECABU_c27980,iECBD_1354.ECBD_1190,iECB_1328.ECB_02390,iECDH10B_1368.ECDH10B_2664,iECDH1ME8569_1439.ECDH1ME8569_2424,iECD_1391.ECD_02390,iECED1_1282.ECED1_2921,iECH74115_1262.ECH74115_3720,iECIAI1_1343.ECIAI1_2550,iECIAI39_1322.ECIAI39_2639,iECNA114_1301.ECNA114_2571,iECO103_1326.ECO103_3015,iECO111_1330.ECO111_3222,iECO26_1355.ECO26_3545,iECOK1_1307.ECOK1_2794,iECP_1309.ECP_2500,iECS88_1305.ECS88_2669,iECSE_1348.ECSE_2784,iECSF_1327.ECSF_2339,iECSP_1301.ECSP_3437,iECUMN_1333.ECUMN_2811,iECW_1372.ECW_m2721,iEKO11_1354.EKO11_1236,iETEC_1333.ETEC_2603,iEcDH1_1363.EcDH1_1171,iEcE24377_1341.EcE24377A_2781,iEcHS_1320.EcHS_A2633,iEcSMS35_1347.EcSMS35_2645,iEcolC_1368.EcolC_1178,iG2583_1286.G2583_3021,iJN746.PP_0746,iJO1366.b2498,iJR904.b2498,iLF82_1304.LF82_2383,iNRG857_1313.NRG857_12410,iSFV_1184.SFV_2543,iSF_1195.SF2542,iS_1188.S2691,iSbBS512_1146.SbBS512_E2872,iUMN146_1321.UM146_04235,iUMNK88_1353.UMNK88_3094,iWFL_1372.ECW_m2721,iY75_1357.Y75_RS13040,ic_1306.c3015 UPRTase SRD1_k127_1092478_0 517418.Ctha_1326 4.786e-146 475.0 COG1160@1|root,COG1160@2|Bacteria,1FDSG@1090|Chlorobi 1090|Chlorobi S GTPase that plays an essential role in the late steps of ribosome biogenesis der - - ko:K03977 - - - - ko00000,ko03009 - - - KH_dom-like,MMR_HSR1 SRD1_k127_1092478_7 1121377.KB906411_gene515 1.546e-22 103.0 COG0784@1|root,COG0784@2|Bacteria 2|Bacteria T Response regulator, receiver - - - - - - - - - - - - Hpt,Response_reg SRD1_k127_1092478_3 880072.Desac_0026 2.528e-61 217.0 COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,42QSV@68525|delta/epsilon subdivisions,2WMZ5@28221|Deltaproteobacteria,2MQRH@213462|Syntrophobacterales 28221|Deltaproteobacteria J TIGRFAM Sua5 YciO YrdC YwlC family protein yrdC - 2.7.7.87 ko:K07566 - - R10463 RC00745 ko00000,ko01000,ko03009,ko03016 - - - Sua5_yciO_yrdC SRD1_k127_1092478_2 215803.DB30_4042 9.432e-72 253.0 COG1028@1|root,COG1028@2|Bacteria,1P9R4@1224|Proteobacteria,42TE9@68525|delta/epsilon subdivisions,2WPGF@28221|Deltaproteobacteria,2YUH5@29|Myxococcales 28221|Deltaproteobacteria IQ Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short SRD1_k127_1092478_5 880073.Calab_3443 1.392e-52 202.0 COG1597@1|root,COG1597@2|Bacteria,2NPQE@2323|unclassified Bacteria 2|Bacteria I Diacylglycerol kinase catalytic domain (presumed) - - - - - - - - - - - - DAGK_cat SRD1_k127_1092478_4 880073.Calab_3442 6.307e-54 198.0 COG2020@1|root,COG2020@2|Bacteria 2|Bacteria O methyltransferase activity - - 2.1.1.334 ko:K21310 ko00920,map00920 - R11546 RC02653 ko00000,ko00001,ko01000 - - - PEMT SRD1_k127_1103548_0 518766.Rmar_2659 7.717e-208 658.0 COG0403@1|root,COG1003@1|root,COG0403@2|Bacteria,COG1003@2|Bacteria,4NEDE@976|Bacteroidetes,1FIJN@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor gcvP - 1.4.4.2 ko:K00281,ko:K00283 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko00002,ko01000 - - - GDC-P SRD1_k127_1104856_1 1379698.RBG1_1C00001G0520 1.716e-69 248.0 COG2208@1|root,COG2208@2|Bacteria 2|Bacteria T phosphoserine phosphatase activity rsbU - 3.1.3.3,4.6.1.1 ko:K01768,ko:K07315 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000,ko03021 - - - CHASE2,GAF,GAF_2,HATPase_c_2,SpoIIE SRD1_k127_1104856_2 761193.Runsl_4020 1.05e-53 215.0 COG4772@1|root,COG4772@2|Bacteria,4NE9I@976|Bacteroidetes,47M2B@768503|Cytophagia 976|Bacteroidetes P TonB-dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - CarbopepD_reg_2,Plug,TonB_dep_Rec SRD1_k127_1104856_0 945713.IALB_1137 1.471e-77 263.0 COG1574@1|root,COG1574@2|Bacteria 2|Bacteria G metal-dependent hydrolase with the TIM-barrel fold - - - - - - - - - - - - Amidohydro_3 SRD1_k127_1124815_2 204669.Acid345_1322 4.493e-24 104.0 COG2259@1|root,COG2259@2|Bacteria,3Y82A@57723|Acidobacteria,2JN7Q@204432|Acidobacteriia 204432|Acidobacteriia S DoxX - - - - - - - - - - - - DoxX SRD1_k127_1124815_0 452637.Oter_3070 8.552e-214 681.0 COG0038@1|root,COG0517@1|root,COG0038@2|Bacteria,COG0517@2|Bacteria,46S9A@74201|Verrucomicrobia,3K9BI@414999|Opitutae 414999|Opitutae P Voltage gated chloride channel - - - - - - - - - - - - CBS,Voltage_CLC SRD1_k127_1124815_1 945713.IALB_3187 1.075e-154 496.0 COG0012@1|root,COG0012@2|Bacteria 2|Bacteria J GTP binding ychF GO:0003674,GO:0003824,GO:0004857,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006950,GO:0006979,GO:0008150,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030234,GO:0043021,GO:0043022,GO:0043023,GO:0043086,GO:0044092,GO:0044424,GO:0044464,GO:0044877,GO:0050790,GO:0050896,GO:0065007,GO:0065009,GO:0098772 - ko:K06942 - - - - ko00000,ko03009 - - - MMR_HSR1,YchF-GTPase_C SRD1_k127_1124815_3 1191523.MROS_0599 1.896e-19 93.0 2BWJ4@1|root,2ZMM0@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - SRD1_k127_1125866_0 404589.Anae109_1439 9.578e-227 720.0 COG0247@1|root,COG0277@1|root,COG0479@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,COG0479@2|Bacteria,1MU6Y@1224|Proteobacteria,42M5I@68525|delta/epsilon subdivisions,2WK8Y@28221|Deltaproteobacteria,2YUG8@29|Myxococcales 28221|Deltaproteobacteria C 4Fe-4S dicluster domain - - - ko:K18930 - - - - ko00000 - - - CCG,FAD-oxidase_C,FAD_binding_4,Fer4_17,Fer4_7,Fer4_8 SRD1_k127_1153753_1 1303518.CCALI_01558 8.694e-73 250.0 COG0058@1|root,COG0058@2|Bacteria 2|Bacteria G glycogen phosphorylase activity - - 2.4.1.1,2.4.1.8 ko:K00688,ko:K00691 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R01555,R02111 RC00049 ko00000,ko00001,ko01000 - GH65,GT35 - DUF3417,Phosphorylase SRD1_k127_1153753_0 1121930.AQXG01000016_gene1824 8.481e-203 650.0 COG0488@1|root,COG0488@2|Bacteria,4NG1W@976|Bacteroidetes,1IPB4@117747|Sphingobacteriia 976|Bacteroidetes S ABC transporter yheS_3 - - ko:K06158 - - - - ko00000,ko03012 - - - ABC_tran,ABC_tran_CTD,ABC_tran_Xtn SRD1_k127_1155464_3 1191523.MROS_0552 2.666e-86 289.0 COG0602@1|root,COG0602@2|Bacteria 2|Bacteria H queuosine metabolic process queE - 1.97.1.4,4.3.99.3 ko:K04068,ko:K10026 ko00790,ko01100,map00790,map01100 - R04710,R10002 RC02989 ko00000,ko00001,ko01000,ko03016 - - iAF987.Gmet_1658 Fer4_14,Radical_SAM SRD1_k127_1155464_2 945713.IALB_0290 1.275e-97 323.0 COG0603@1|root,COG0603@2|Bacteria 2|Bacteria F Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) queC - 6.3.4.20 ko:K06920 ko00790,ko01100,map00790,map01100 - R09978 RC00959 ko00000,ko00001,ko01000,ko03016 - - iAF987.Gmet_3075 QueC SRD1_k127_1155464_1 1329516.JPST01000048_gene1913 3.129e-228 716.0 COG1838@1|root,COG1951@1|root,COG1838@2|Bacteria,COG1951@2|Bacteria,1TPXQ@1239|Firmicutes,4HA3C@91061|Bacilli,27B2P@186824|Thermoactinomycetaceae 91061|Bacilli C Fumarase C-terminus fumA - 4.2.1.2 ko:K01676 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - - Fumerase,Fumerase_C SRD1_k127_1155464_0 1191523.MROS_2357 9.258e-233 731.0 COG1022@1|root,COG1022@2|Bacteria 2|Bacteria I Amp-dependent synthetase and ligase - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C SRD1_k127_1165492_3 945713.IALB_3152 9.323e-22 103.0 COG3503@1|root,COG3503@2|Bacteria 2|Bacteria J Membrane - - - - - - - - - - - - DUF1624 SRD1_k127_1165492_4 111781.Lepto7376_2715 2.363e-16 83.0 COG0745@1|root,COG2114@1|root,COG0745@2|Bacteria,COG2114@2|Bacteria,1G1FK@1117|Cyanobacteria,1H8GM@1150|Oscillatoriales 1117|Cyanobacteria T PFAM Adenylate and Guanylate cyclase catalytic domain - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_cyc,Response_reg SRD1_k127_1165492_2 1123242.JH636434_gene3901 1.683e-63 237.0 COG3349@1|root,COG3349@2|Bacteria,2IXN4@203682|Planctomycetes 203682|Planctomycetes E TIGRFAM squalene-associated FAD-dependent desaturase - - - - - - - - - - - - Amino_oxidase SRD1_k127_1165492_0 1191523.MROS_2828 1.907e-81 284.0 COG1562@1|root,COG1562@2|Bacteria 2|Bacteria I ergosterol biosynthetic process crtB - 2.5.1.32,2.5.1.99 ko:K02291 ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110 M00097 R02065,R04218,R07270,R10177 RC00362,RC01101,RC02869 ko00000,ko00001,ko00002,ko01000,ko01006 - - - SQS_PSY SRD1_k127_1165492_1 1123368.AUIS01000001_gene2032 2.131e-80 277.0 COG1562@1|root,COG1562@2|Bacteria,1N6J2@1224|Proteobacteria,1S3EY@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Squalene/phytoene synthase - - - - - - - - - - - - SQS_PSY SRD1_k127_1200886_2 1396141.BATP01000003_gene5111 8.466e-36 142.0 COG0745@1|root,COG1235@1|root,COG2203@1|root,COG0745@2|Bacteria,COG1235@2|Bacteria,COG2203@2|Bacteria,46UKB@74201|Verrucomicrobia,2IVU2@203494|Verrucomicrobiae 203494|Verrucomicrobiae KT Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B_2,Response_reg SRD1_k127_1200886_1 880073.Calab_0106 4.351e-38 149.0 2E8AI@1|root,332PD@2|Bacteria,2NRHQ@2323|unclassified Bacteria 2|Bacteria - - - - - - - - - - - - - - - SRD1_k127_1200886_3 319225.Plut_1354 2.033e-24 113.0 COG0319@1|root,COG0319@2|Bacteria,1FE4W@1090|Chlorobi 1090|Chlorobi J Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA ybeY - - - - - - - - - - - UPF0054 SRD1_k127_1200886_4 765913.ThidrDRAFT_0372 1.733e-07 59.0 COG2922@1|root,COG2922@2|Bacteria,1RD5F@1224|Proteobacteria,1S43X@1236|Gammaproteobacteria,1WYZ6@135613|Chromatiales 135613|Chromatiales S Belongs to the Smg family smg - - ko:K03747 - - - - ko00000 - - - DUF494 SRD1_k127_1200886_0 517418.Ctha_0433 6.079e-99 332.0 COG0550@1|root,COG0551@1|root,COG0550@2|Bacteria,COG0551@2|Bacteria,1FD5Q@1090|Chlorobi 1090|Chlorobi L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone topA - 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topoisom_bac,Toprim,zf-C4_Topoisom SRD1_k127_1205184_1 880073.Calab_1670 1.249e-118 392.0 COG0520@1|root,COG0520@2|Bacteria,2NNS0@2323|unclassified Bacteria 2|Bacteria E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine csdA - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 SRD1_k127_1205184_2 880073.Calab_0105 5.273e-88 300.0 COG4974@1|root,COG4974@2|Bacteria,2NNN8@2323|unclassified Bacteria 2|Bacteria L Phage integrase, N-terminal SAM-like domain xerC - - ko:K03733,ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase SRD1_k127_1205184_0 1191523.MROS_1746 5.769e-168 555.0 COG1480@1|root,COG1480@2|Bacteria 2|Bacteria O 7TM receptor with intracellular HD hydrolase yqfF - - ko:K07037 - - - - ko00000 - - - 7TM-7TMR_HD,7TMR-HDED,HD SRD1_k127_1205184_3 1047013.AQSP01000128_gene441 4.164e-49 190.0 COG0628@1|root,COG0628@2|Bacteria,2NPIB@2323|unclassified Bacteria 2|Bacteria S AI-2E family transporter - - - ko:K11744 - - - - ko00000 - - - AI-2E_transport SRD1_k127_1205184_4 138119.DSY1713 5.751e-28 115.0 COG0247@1|root,COG2181@1|root,COG0247@2|Bacteria,COG2181@2|Bacteria,1TPG1@1239|Firmicutes,24BBE@186801|Clostridia,260K6@186807|Peptococcaceae 186801|Clostridia C Fe-S oxidoreductase - - - - - - - - - - - - CCG,Fer4_8,Nitrate_red_gam SRD1_k127_120857_0 1158294.JOMI01000004_gene3502 9.745e-154 501.0 COG3250@1|root,COG3250@2|Bacteria,4NEDF@976|Bacteroidetes,2FMTQ@200643|Bacteroidia 976|Bacteroidetes G Belongs to the glycosyl hydrolase 2 family - - 3.2.1.23 ko:K01190 ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100 - R01105,R01678,R03355,R04783,R06114 RC00049,RC00452 ko00000,ko00001,ko01000 - - - DUF4982,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N SRD1_k127_1211876_3 945713.IALB_1067 3.642e-74 259.0 COG0483@1|root,COG0483@2|Bacteria 2|Bacteria G inositol monophosphate 1-phosphatase activity suhB GO:0003674,GO:0003824,GO:0005975,GO:0006020,GO:0006066,GO:0006793,GO:0006796,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008934,GO:0009056,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0019751,GO:0023052,GO:0042578,GO:0043647,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0046164,GO:0046174,GO:0046434,GO:0046838,GO:0046855,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0052745,GO:0052834,GO:0065007,GO:0071545,GO:0071704,GO:1901575,GO:1901615,GO:1901616 3.1.3.25,3.1.3.7 ko:K01082,ko:K01092 ko00521,ko00562,ko00920,ko01100,ko01120,ko01130,ko04070,map00521,map00562,map00920,map01100,map01120,map01130,map04070 M00131 R00188,R00508,R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000,ko03016 - - - Inositol_P SRD1_k127_1211876_0 518766.Rmar_2721 2.116e-130 432.0 COG2262@1|root,COG2262@2|Bacteria,4NF0P@976|Bacteroidetes,1FIUG@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis hflX - - ko:K03665 - - - - ko00000,ko03009 - - - GTP-bdg_M,GTP-bdg_N,MMR_HSR1 SRD1_k127_1211876_2 518766.Rmar_2723 1.686e-96 344.0 COG2304@1|root,COG2304@2|Bacteria,4NFQQ@976|Bacteroidetes 976|Bacteroidetes S TIGRFAM N-terminal double-transmembrane domain - - - - - - - - - - - - BatA SRD1_k127_1211876_1 945713.IALB_1647 5.095e-123 414.0 28KE7@1|root,2ZA0G@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - SRD1_k127_1221698_1 113355.CM001775_gene2363 1e-13 74.0 COG1724@1|root,COG1724@2|Bacteria,1G9BE@1117|Cyanobacteria 1117|Cyanobacteria N HicA toxin of bacterial toxin-antitoxin, - - - - - - - - - - - - HicA_toxin SRD1_k127_1221698_2 880072.Desac_2172 6.677e-13 72.0 arCOG07300@1|root,2ZTGG@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - SRD1_k127_1221698_0 880072.Desac_2179 2.981e-16 88.0 COG0468@1|root,COG0468@2|Bacteria 2|Bacteria L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage - - - - - - - - - - - - AAA_12,AAA_24,AAA_25,DUF4011 SRD1_k127_1221698_3 1396418.BATQ01000133_gene4024 4.718e-07 61.0 COG1801@1|root,COG1801@2|Bacteria,46TUG@74201|Verrucomicrobia 74201|Verrucomicrobia S Protein of unknown function DUF72 - - - - - - - - - - - - DUF72 SRD1_k127_1239696_3 1121861.KB899923_gene3370 6.525e-06 57.0 COG0584@1|root,COG0584@2|Bacteria,1MW6Z@1224|Proteobacteria,2V78M@28211|Alphaproteobacteria,2JSGH@204441|Rhodospirillales 204441|Rhodospirillales C Glycerophosphoryl diester phosphodiesterase family - - 3.1.4.46 ko:K01126 ko00564,map00564 - R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 - - - GDPD SRD1_k127_1239696_0 501479.ACNW01000090_gene2329 1.056e-91 314.0 COG1236@1|root,COG1236@2|Bacteria,1MV7U@1224|Proteobacteria,2TQU5@28211|Alphaproteobacteria 28211|Alphaproteobacteria J exonuclease of the beta-lactamase fold involved in RNA processing MA20_22065 - - ko:K07577 - - - - ko00000 - - - Lactamase_B SRD1_k127_1239696_1 1294273.roselon_03311 2.377e-76 275.0 COG1793@1|root,COG1793@2|Bacteria,1MV3S@1224|Proteobacteria,2TRQ9@28211|Alphaproteobacteria 28211|Alphaproteobacteria L DNA ligase lig - 6.5.1.1,6.5.1.6,6.5.1.7 ko:K10747 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00381,R00382,R10822,R10823 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N SRD1_k127_1239696_2 574087.Acear_0893 3.701e-61 217.0 COG2065@1|root,COG2065@2|Bacteria,1V3GV@1239|Firmicutes,24FQD@186801|Clostridia,3WAIW@53433|Halanaerobiales 186801|Clostridia F Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant pyrR - 2.4.2.9 ko:K02825 ko00240,ko01100,map00240,map01100 - R00966 RC00063 ko00000,ko00001,ko01000,ko03000 - - iHN637.CLJU_RS05275 Pribosyltran SRD1_k127_1245678_3 1307436.PBF_18279 3.042e-39 153.0 COG1670@1|root,COG1670@2|Bacteria,1V4T4@1239|Firmicutes,4HGGP@91061|Bacilli,1ZGQ5@1386|Bacillus 91061|Bacilli J Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_3 SRD1_k127_1245678_6 1123508.JH636439_gene1262 5.759e-05 54.0 2DNKX@1|root,32Y1B@2|Bacteria,2J0P2@203682|Planctomycetes 203682|Planctomycetes S Glycine zipper - - - - - - - - - - - - Gly-zipper_Omp SRD1_k127_1245678_1 945713.IALB_2280 2.969e-54 198.0 COG2865@1|root,COG2865@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - AlbA_2 SRD1_k127_1245678_2 56780.SYN_01407 2.812e-50 191.0 COG0744@1|root,COG0744@2|Bacteria,1RDAQ@1224|Proteobacteria,42MBJ@68525|delta/epsilon subdivisions,2WNWX@28221|Deltaproteobacteria,2MQKM@213462|Syntrophobacterales 28221|Deltaproteobacteria M Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors mtgA - 2.4.1.129 ko:K03814 ko00550,map00550 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly SRD1_k127_1245678_5 1408310.JHUW01000010_gene2521 2.278e-23 109.0 COG0816@1|root,COG0816@2|Bacteria,4NQ8B@976|Bacteroidetes,2FT2Q@200643|Bacteroidia 976|Bacteroidetes L Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA ruvX GO:0000966,GO:0000967,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 - ko:K07447 - - - - ko00000,ko01000 - - - RuvX SRD1_k127_1245678_0 945713.IALB_1378 1.029e-291 912.0 COG0317@1|root,COG0317@2|Bacteria 2|Bacteria KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance relA - 2.7.6.5,3.1.7.2 ko:K00951,ko:K01139 ko00230,map00230 - R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 - - - ACT_4,HD_4,RelA_SpoT,TGS SRD1_k127_1245678_4 1123392.AQWL01000005_gene3106 7.184e-33 135.0 COG0237@1|root,COG0237@2|Bacteria,1RCXT@1224|Proteobacteria,2VR8K@28216|Betaproteobacteria,1KSTI@119069|Hydrogenophilales 119069|Hydrogenophilales F Dephospho-CoA kinase - - 2.7.1.24 ko:K00859 ko00770,ko01100,map00770,map01100 M00120 R00130 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - CoaE SRD1_k127_1250687_3 1191523.MROS_0285 1.005e-19 93.0 2E09V@1|root,32VXB@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - SRD1_k127_1250687_0 1191523.MROS_0286 0.0 1034.0 COG1629@1|root,COG4771@2|Bacteria 2|Bacteria P TonB-dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,CarboxypepD_reg,Plug SRD1_k127_1250687_1 378806.STAUR_8302 9.922e-67 236.0 COG3279@1|root,COG3279@2|Bacteria,1MUE8@1224|Proteobacteria,42RCM@68525|delta/epsilon subdivisions,2WN89@28221|Deltaproteobacteria,2YVX5@29|Myxococcales 28221|Deltaproteobacteria K LytTr DNA-binding domain - - - ko:K02477 - - - - ko00000,ko02022 - - - LytTR,Response_reg SRD1_k127_1250687_2 1254432.SCE1572_26545 1.201e-62 231.0 COG2972@1|root,COG2972@2|Bacteria,1MXVQ@1224|Proteobacteria,42R4U@68525|delta/epsilon subdivisions,2X799@28221|Deltaproteobacteria,2Z0T8@29|Myxococcales 28221|Deltaproteobacteria T Histidine kinase - - 2.7.13.3 ko:K08082 ko02020,map02020 M00493 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - His_kinase SRD1_k127_125407_2 945713.IALB_0830 6.817e-78 268.0 COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria 2|Bacteria T phosphoserine phosphatase activity rsbU - 3.1.3.3,4.6.1.1 ko:K01768,ko:K07315 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000,ko03021 - - - GAF,GAF_2,GAF_3,HATPase_c_2,SSF,SpoIIE SRD1_k127_125407_4 518766.Rmar_0404 7.82e-66 235.0 COG4974@1|root,COG4974@2|Bacteria,4PEGI@976|Bacteroidetes,1FJ39@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes L Belongs to the 'phage' integrase family - - - ko:K03733 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase SRD1_k127_125407_0 471223.GWCH70_2764 0.0 1054.0 COG0495@1|root,COG0495@2|Bacteria,1TP0Y@1239|Firmicutes,4HAG1@91061|Bacilli,1WFBD@129337|Geobacillus 91061|Bacilli J Belongs to the class-I aminoacyl-tRNA synthetase family leuS GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 SRD1_k127_125407_5 748449.Halha_2398 6.405e-55 202.0 COG1216@1|root,COG1216@2|Bacteria,1UIHC@1239|Firmicutes,25F9A@186801|Clostridia,3WADS@53433|Halanaerobiales 186801|Clostridia S PFAM Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 SRD1_k127_125407_1 945713.IALB_0362 3.832e-218 692.0 COG1132@1|root,COG1132@2|Bacteria 2|Bacteria V (ABC) transporter msbA - - ko:K02021,ko:K06147,ko:K06148,ko:K11085 ko02010,map02010 - - - ko00000,ko00001,ko01000,ko02000 3.A.1,3.A.1.106,3.A.1.109,3.A.1.110,3.A.1.112,3.A.1.113,3.A.1.117,3.A.1.21 - - ABC_membrane,ABC_tran SRD1_k127_125407_7 234267.Acid_4123 4.797e-14 85.0 COG3307@1|root,COG3307@2|Bacteria,3Y67G@57723|Acidobacteria 57723|Acidobacteria M O-antigen ligase like membrane protein - - - - - - - - - - - - Wzy_C SRD1_k127_125407_3 1191523.MROS_1750 2.383e-73 271.0 COG0463@1|root,COG0463@2|Bacteria 2|Bacteria M Glycosyl transferase, family 2 kdtX - - ko:K12984 - - - - ko00000,ko01000,ko01003,ko01005,ko02000 4.D.1.3 GT2 - Glycos_transf_2 SRD1_k127_125407_6 1379698.RBG1_1C00001G0404 4.131e-14 74.0 2EAFJ@1|root,334IY@2|Bacteria,2NRZR@2323|unclassified Bacteria 2|Bacteria S Domain of unknown function (DUF1844) - - - - - - - - - - - - DUF1844 SRD1_k127_1270850_0 926550.CLDAP_34250 1.155e-79 275.0 COG0696@1|root,COG0696@2|Bacteria,2G7GD@200795|Chloroflexi 200795|Chloroflexi F Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate - - - - - - - - - - - - Metalloenzyme SRD1_k127_1270850_2 518766.Rmar_2367 1.986e-48 178.0 COG1490@1|root,COG1490@2|Bacteria,4NNFF@976|Bacteroidetes,1FJDS@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality dtd GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360 - ko:K07560 - - - - ko00000,ko01000,ko03016 - - - Tyr_Deacylase SRD1_k127_1270850_1 338963.Pcar_2691 3.259e-49 183.0 COG2890@1|root,COG2890@2|Bacteria,1MXCQ@1224|Proteobacteria,42PKA@68525|delta/epsilon subdivisions,2WM9R@28221|Deltaproteobacteria,43S3F@69541|Desulfuromonadales 28221|Deltaproteobacteria J Putative RNA methylase family UPF0020 prmC - 2.1.1.297 ko:K02493 - - R10806 RC00003,RC03279 ko00000,ko01000,ko03012 - - - MTS,Methyltransf_25,Methyltransf_31 SRD1_k127_1272766_1 1089553.Tph_c24780 1.405e-23 104.0 COG2871@1|root,COG3894@1|root,COG2871@2|Bacteria,COG3894@2|Bacteria,1TP0H@1239|Firmicutes,247S0@186801|Clostridia,42F3G@68295|Thermoanaerobacterales 186801|Clostridia C PFAM ferredoxin - - - - - - - - - - - - DUF4445,Fer2 SRD1_k127_1272766_0 485915.Dret_1750 1.326e-205 657.0 COG0021@1|root,COG0021@2|Bacteria 2|Bacteria G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate - - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_N,XFP,XFP_N SRD1_k127_1282522_5 1382359.JIAL01000001_gene668 0.000404 47.0 COG0845@1|root,COG0845@2|Bacteria,3Y2XB@57723|Acidobacteria,2JI4U@204432|Acidobacteriia 204432|Acidobacteriia M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - HlyD_D23 SRD1_k127_1282522_4 926562.Oweho_2421 1.971e-18 89.0 COG2207@1|root,COG2207@2|Bacteria,4NVDF@976|Bacteroidetes 976|Bacteroidetes K Transcriptional regulator - - - - - - - - - - - - - SRD1_k127_1282522_0 1382306.JNIM01000001_gene329 2.909e-144 482.0 COG0183@1|root,COG0183@2|Bacteria,2G5YW@200795|Chloroflexi 200795|Chloroflexi I Belongs to the thiolase family - - - - - - - - - - - - Thiolase_C,Thiolase_N SRD1_k127_1282522_3 237368.SCABRO_01224 8.106e-25 114.0 2DBYC@1|root,2ZBUF@2|Bacteria,2IZ15@203682|Planctomycetes 203682|Planctomycetes S Protein of unknown function (DUF1573) - - - - - - - - - - - - DUF1573 SRD1_k127_1282522_2 1120973.AQXL01000122_gene141 1.072e-39 157.0 COG1250@1|root,COG1250@2|Bacteria,1TSZI@1239|Firmicutes,4HBK3@91061|Bacilli,279Y5@186823|Alicyclobacillaceae 91061|Bacilli I 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain - - 1.1.1.157 ko:K00074 ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120 - R01976,R05576,R06941 RC00029,RC00117 ko00000,ko00001,ko01000 - - - 3HCDH,3HCDH_N SRD1_k127_1282522_1 1120973.AQXL01000122_gene140 1.289e-76 263.0 COG1250@1|root,COG1250@2|Bacteria,1UUAQ@1239|Firmicutes,4HBSJ@91061|Bacilli 91061|Bacilli I Dehydrogenase - - 1.1.1.157 ko:K00074 ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120 - R01976,R05576,R06941 RC00029,RC00117 ko00000,ko00001,ko01000 - - - 3HCDH,3HCDH_N SRD1_k127_1314136_1 880073.Calab_2216 2.839e-89 310.0 COG1404@1|root,COG1404@2|Bacteria 2|Bacteria O Belongs to the peptidase S8 family ebh - - - - - - - - - - - DUF1611,Inhibitor_I9,Peptidase_S8,SLH SRD1_k127_1314136_0 518766.Rmar_0357 1.922e-97 329.0 COG2067@1|root,COG2067@2|Bacteria 2|Bacteria I long-chain fatty acid transporting porin activity - - - - - - - - - - - - UPF0164 SRD1_k127_1314136_2 880073.Calab_2962 9.347e-05 49.0 COG0760@1|root,COG0760@2|Bacteria 2|Bacteria O peptidyl-prolyl cis-trans isomerase activity - - 5.2.1.8 ko:K01802,ko:K03770 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_2,SurA_N_3 SRD1_k127_1318354_0 1123008.KB905694_gene1500 5.288e-63 228.0 COG2234@1|root,COG2234@2|Bacteria,4NFDJ@976|Bacteroidetes,2FQ2M@200643|Bacteroidia,22XAT@171551|Porphyromonadaceae 976|Bacteroidetes S Peptidase family M28 - - - - - - - - - - - - PA,Peptidase_M28 SRD1_k127_1318354_1 929713.NIASO_09635 0.0001441 53.0 2E676@1|root,330VQ@2|Bacteria,4NWHJ@976|Bacteroidetes,1ITZQ@117747|Sphingobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - SRD1_k127_131922_3 349741.Amuc_1938 4.199e-06 50.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,46URE@74201|Verrucomicrobia,2ITXE@203494|Verrucomicrobiae 203494|Verrucomicrobiae L Helix-hairpin-helix class 2 (Pol1 family) motifs - - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 SRD1_k127_131922_0 760568.Desku_3129 1.867e-87 304.0 COG0477@1|root,COG2814@2|Bacteria,1TRDJ@1239|Firmicutes,247N6@186801|Clostridia,2642T@186807|Peptococcaceae 186801|Clostridia EGP major facilitator superfamily mdtG2 - - ko:K08161 - - - - ko00000,ko02000 2.A.1.2.20 - - MFS_1,Sugar_tr SRD1_k127_131922_1 867845.KI911784_gene3308 2.481e-57 208.0 COG2096@1|root,COG2096@2|Bacteria,2G6TB@200795|Chloroflexi,3777D@32061|Chloroflexia 32061|Chloroflexia S PFAM cobalamin adenosyltransferase - - 2.5.1.17 ko:K00798 ko00860,ko01100,map00860,map01100 M00122 R01492,R05220,R07268 RC00533 ko00000,ko00001,ko00002,ko01000 - - - Cob_adeno_trans SRD1_k127_131922_2 1907.SGLAU_02315 1.513e-15 91.0 COG2234@1|root,COG4935@1|root,COG2234@2|Bacteria,COG4935@2|Bacteria,2GIT0@201174|Actinobacteria 201174|Actinobacteria E Peptidase, M28 - - 3.4.11.24 ko:K19702 - - - - ko00000,ko01000,ko01002 - - - P_proprotein,Peptidase_M28 SRD1_k127_1323979_0 518766.Rmar_1796 1.277e-72 257.0 COG1136@1|root,COG1136@2|Bacteria,4NGDU@976|Bacteroidetes,1FIZP@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner lolD - - ko:K09810 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.125 - - ABC_tran SRD1_k127_1323979_1 880073.Calab_1381 6.411e-27 113.0 COG4591@1|root,COG4591@2|Bacteria,2NP18@2323|unclassified Bacteria 2|Bacteria M ABC-type transport system involved in lipoprotein release permease component lolC GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008104,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032991,GO:0033036,GO:0034613,GO:0044425,GO:0044459,GO:0044464,GO:0044872,GO:0044873,GO:0044874,GO:0051179,GO:0051641,GO:0070727,GO:0071944,GO:0072657,GO:0089705,GO:0098796,GO:0098797,GO:1990778 - ko:K02004,ko:K09808 ko02010,map02010 M00255,M00258 - - ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.125 - - FtsX,MacB_PCD SRD1_k127_1342893_0 945713.IALB_2161 5.517e-133 450.0 COG4206@1|root,COG4206@2|Bacteria 2|Bacteria H cobalamin-transporting ATPase activity - - - ko:K02014,ko:K16092 - - - - ko00000,ko02000 1.B.14,1.B.14.3 - - CarbopepD_reg_2,Plug,TonB_dep_Rec SRD1_k127_1376061_0 945713.IALB_1728 1.276e-160 518.0 COG0823@1|root,COG4775@1|root,COG0823@2|Bacteria,COG4775@2|Bacteria 2|Bacteria M membrane organization - - - ko:K03641,ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33,2.C.1.2 - - BSP,Bac_surface_Ag,PD40,Peptidase_MA_2 SRD1_k127_1376061_1 797302.Halru_2437 1.122e-23 114.0 COG1361@1|root,COG1520@1|root,COG3291@1|root,COG3979@1|root,arCOG02088@1|root,arCOG07560@1|root,arCOG10954@1|root,arCOG02088@2157|Archaea,arCOG02492@2157|Archaea,arCOG02508@2157|Archaea,arCOG04400@2157|Archaea,arCOG07560@2157|Archaea,arCOG07581@2157|Archaea,arCOG10954@2157|Archaea,2Y7Q0@28890|Euryarchaeota,23SYZ@183963|Halobacteria 183963|Halobacteria M COG1520 FOG WD40-like repeat - - - - - - - - - - - - CARDB,CarboxypepD_reg,PKD,PQQ_2,PQQ_3 SRD1_k127_1387503_1 1191523.MROS_0962 3.996e-17 95.0 COG2911@1|root,COG3867@1|root,COG2911@2|Bacteria,COG3867@2|Bacteria 2|Bacteria G arabinogalactan endo-1,4-beta-galactosidase activity - - - - - - - - - - - - Big_4,F5_F8_type_C,FlgD_ig,Glyco_hydro_53,He_PIG,Peptidase_S74,RicinB_lectin_2,SLH,fn3 SRD1_k127_1387503_2 1519464.HY22_06660 1.87e-14 83.0 COG4447@1|root,COG4447@2|Bacteria 2|Bacteria S cellulose binding - - - - - - - - - - - - FlgD_ig,MAM,Sortilin-Vps10,TIG,fn3 SRD1_k127_1387503_0 694427.Palpr_2721 1.688e-81 278.0 COG1629@1|root,COG4771@2|Bacteria,4NF4B@976|Bacteroidetes,2FM7I@200643|Bacteroidia,22XCB@171551|Porphyromonadaceae 976|Bacteroidetes P TonB-dependent receptor plug domain - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec SRD1_k127_1387649_0 1047013.AQSP01000142_gene234 1.81e-81 283.0 COG2304@1|root,COG2304@2|Bacteria,2NPUS@2323|unclassified Bacteria 2|Bacteria S IgA Peptidase M64 - - - - - - - - - - - - M64_N,Peptidase_M64,VWA SRD1_k127_1387649_4 1196322.A370_01864 5.421e-13 76.0 COG1917@1|root,COG1917@2|Bacteria 2|Bacteria L Cupin 2, conserved barrel domain protein - - - - - - - - - - - - Cupin_2,Globin,HTH_19,HTH_26,HTH_3,HTH_31 SRD1_k127_1387649_1 517418.Ctha_1645 8.717e-73 256.0 COG0388@1|root,COG0388@2|Bacteria,1FDC4@1090|Chlorobi 1090|Chlorobi S PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase - - - - - - - - - - - - CN_hydrolase SRD1_k127_1387649_3 573065.Astex_1996 2.266e-17 93.0 COG0642@1|root,COG0745@1|root,COG0784@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2V5S6@28211|Alphaproteobacteria,2KHZ3@204458|Caulobacterales 204458|Caulobacterales T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,Response_reg SRD1_k127_1387649_2 1173028.ANKO01000056_gene2163 1.047e-68 256.0 COG2202@1|root,COG4251@1|root,COG2202@2|Bacteria,COG4251@2|Bacteria,1G1Z5@1117|Cyanobacteria,1HH3F@1150|Oscillatoriales 1117|Cyanobacteria T PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - GAF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9 SRD1_k127_1400539_1 1151117.AJLF01000002_gene430 9.603e-68 244.0 COG1653@1|root,arCOG00151@2157|Archaea,2Y0AI@28890|Euryarchaeota,243YU@183968|Thermococci 183968|Thermococci G Bacterial extracellular solute-binding protein - - - ko:K02027 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - SBP_bac_1 SRD1_k127_1400539_0 1168289.AJKI01000053_gene795 5.322e-81 284.0 COG3537@1|root,COG3537@2|Bacteria,4NDYB@976|Bacteroidetes,2FMQP@200643|Bacteroidia,3XKSK@558415|Marinilabiliaceae 976|Bacteroidetes G Glycosyl hydrolase family 92 - - - - - - - - - - - - Glyco_hydro_92 SRD1_k127_1418537_2 1519464.HY22_12675 5.485e-52 206.0 COG0457@1|root,COG2755@1|root,COG0457@2|Bacteria,COG2755@2|Bacteria 2|Bacteria E lipolytic protein G-D-S-L family - - - ko:K00612 - - - - ko00000,ko01000 - - - Lipase_GDSL_2,SLH,TPR_19,TPR_8 SRD1_k127_1418537_3 945713.IALB_2729 2.679e-49 201.0 COG0760@1|root,COG0760@2|Bacteria 2|Bacteria O peptidyl-prolyl cis-trans isomerase activity - - 5.2.1.8 ko:K01802,ko:K03770 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_2,SurA_N_3 SRD1_k127_1418537_1 1191523.MROS_2839 2.516e-75 278.0 COG0457@1|root,COG2755@1|root,COG0457@2|Bacteria,COG2755@2|Bacteria 2|Bacteria E lipolytic protein G-D-S-L family - - - ko:K00612 - - - - ko00000,ko01000 - - - Lipase_GDSL_2,SLH,TPR_19,TPR_8 SRD1_k127_1418537_0 880073.Calab_0926 4.414e-214 681.0 COG0366@1|root,COG3280@1|root,COG0366@2|Bacteria,COG3280@2|Bacteria,2NP2D@2323|unclassified Bacteria 2|Bacteria G Alpha amylase, catalytic domain malZ - 2.4.1.25,2.4.1.4,3.2.1.1,3.2.1.133,3.2.1.135,3.2.1.20,3.2.1.54 ko:K00705,ko:K01176,ko:K01187,ko:K01208,ko:K05341,ko:K21575 ko00052,ko00500,ko01100,ko04973,map00052,map00500,map01100,map04973 - R00028,R00801,R00802,R01823,R02108,R02112,R03122,R05196,R06087,R06088,R11262 RC00028,RC00049,RC00077 ko00000,ko00001,ko01000 - GH13,GH31,GH77 - Alpha-amylase,Glyco_hydro_77,Malt_amylase_C SRD1_k127_1418537_4 518766.Rmar_0280 6.498e-09 63.0 COG0760@1|root,COG0760@2|Bacteria,4P6YB@976|Bacteroidetes 976|Bacteroidetes O PPIC-type PPIASE domain - - - - - - - - - - - - Rotamase SRD1_k127_145393_2 1192034.CAP_3935 3.75e-17 90.0 COG0558@1|root,COG0558@2|Bacteria 2|Bacteria I Belongs to the CDP-alcohol phosphatidyltransferase class-I family - - - - - - - - - - - - CDP-OH_P_transf SRD1_k127_145393_0 1121468.AUBR01000005_gene101 4.478e-125 411.0 COG0205@1|root,COG0205@2|Bacteria,1TPF4@1239|Firmicutes,249AM@186801|Clostridia,42EQ1@68295|Thermoanaerobacterales 186801|Clostridia H Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis pfkA2 - 2.7.1.11,2.7.1.90 ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130 - R00756,R00764,R02073,R03236,R04779 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PFK SRD1_k127_145393_1 518766.Rmar_2480 7.81e-100 334.0 COG1158@1|root,COG1158@2|Bacteria,4NZWZ@976|Bacteroidetes,1FIJE@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template - - - ko:K03628 ko03018,map03018 - - - ko00000,ko00001,ko03019,ko03021 - - - ATP-synt_ab,Rho_RNA_bind SRD1_k127_146949_2 32057.KB217478_gene963 1.027e-22 104.0 COG0463@1|root,COG0463@2|Bacteria,1GEJY@1117|Cyanobacteria,1HTJE@1161|Nostocales 1117|Cyanobacteria M Glycosyl transferase family 2 - - 2.4.1.83 ko:K00721 ko00510,ko01100,map00510,map01100 - R01009 RC00005 ko00000,ko00001,ko01000,ko01003 - GT2 - Glycos_transf_2 SRD1_k127_146949_1 2074.JNYD01000001_gene6288 5.864e-42 175.0 COG1807@1|root,COG1807@2|Bacteria 2|Bacteria M 4-amino-4-deoxy-L-arabinose transferase activity - - - ko:K14340 - - - - ko00000,ko01000,ko01003 - - - PMT_2 SRD1_k127_146949_3 945713.IALB_3179 3.767e-15 89.0 COG1404@1|root,COG1404@2|Bacteria 2|Bacteria O Belongs to the peptidase S8 family - - - - - - - - - - - - Calx-beta,CarboxypepD_reg,DUF1524,Polysacc_deac_1,SLH SRD1_k127_146949_0 761193.Runsl_4744 1.137e-87 308.0 COG0383@1|root,COG0383@2|Bacteria,4NEC3@976|Bacteroidetes,47NE0@768503|Cytophagia 976|Bacteroidetes G Glycosyl hydrolases family 38 C-terminal domain - - 3.2.1.24 ko:K01191 ko00511,map00511 - - - ko00000,ko00001,ko01000,ko04131 - GH38 - Glyco_hydro_38,Glyco_hydro_38C SRD1_k127_1500573_1 1340493.JNIF01000003_gene4261 3.248e-39 156.0 COG0526@1|root,COG0526@2|Bacteria,3Y4K8@57723|Acidobacteria 57723|Acidobacteria CO PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - ko:K02199 - - - - ko00000,ko03110 - - - AhpC-TSA SRD1_k127_1500573_0 644966.Tmar_0327 2.547e-156 522.0 COG0209@1|root,COG0209@2|Bacteria,1TPFH@1239|Firmicutes,249EN@186801|Clostridia,3WCXH@538999|Clostridiales incertae sedis 186801|Clostridia F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen - - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN SRD1_k127_1505460_0 1047013.AQSP01000141_gene118 1.862e-166 561.0 COG0642@1|root,COG3292@1|root,COG3920@1|root,COG2205@2|Bacteria,COG3292@2|Bacteria,COG3920@2|Bacteria,2NNZT@2323|unclassified Bacteria 2|Bacteria T Two component regulator propeller pdtaS - 2.7.13.3 ko:K00936 - M00839 - - ko00000,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HATPase_c_2,H_kinase_N,HisKA_2,Reg_prop SRD1_k127_151511_1 240015.ACP_1006 5.675e-143 462.0 COG0626@1|root,COG0626@2|Bacteria,3Y2K5@57723|Acidobacteria,2JHVD@204432|Acidobacteriia 204432|Acidobacteriia E Cys/Met metabolism PLP-dependent enzyme - - 4.4.1.1,4.4.1.2,4.4.1.8 ko:K01760,ko:K17217 ko00260,ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00260,map00270,map00450,map00920,map01100,map01110,map01130,map01230 M00017,M00609 R00782,R01001,R01283,R01286,R02408,R04941 RC00056,RC00069,RC00348,RC00382,RC00487,RC00488,RC00710,RC01245,RC02303,RC02814 ko00000,ko00001,ko00002,ko01000 - - - Cys_Met_Meta_PP SRD1_k127_151511_0 1519464.HY22_12340 1.127e-288 910.0 COG1109@1|root,COG1208@1|root,COG1109@2|Bacteria,COG1208@2|Bacteria,1FEI3@1090|Chlorobi 1090|Chlorobi GJM Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III - - 2.7.7.13,5.4.2.8 ko:K16881 ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130 M00114,M00362 R00885,R01818 RC00002,RC00408 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transferase,PGM_PMM_I,PGM_PMM_II,PGM_PMM_III SRD1_k127_151511_2 1191523.MROS_0370 6.855e-50 181.0 COG1762@1|root,COG1762@2|Bacteria 2|Bacteria G phosphoenolpyruvate-dependent sugar phosphotransferase system - - 2.7.1.202 ko:K02768,ko:K02769,ko:K02770,ko:K02806 ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060 M00273 R03232 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.2.1 - - PTS_EIIA_2 SRD1_k127_151511_3 1519464.HY22_14250 1.278e-40 155.0 COG0682@1|root,COG0682@2|Bacteria 2|Bacteria M lipoprotein biosynthetic process lgt - - ko:K13292 - - - - ko00000,ko01000 - - - LGT SRD1_k127_1549021_0 880073.Calab_3486 1.724e-109 368.0 COG4992@1|root,COG4992@2|Bacteria,2NP1Z@2323|unclassified Bacteria 2|Bacteria E Aminotransferase class-III argD - 2.6.1.11,2.6.1.13,2.6.1.17 ko:K00819,ko:K00821 ko00220,ko00300,ko00330,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map00330,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00028,M00845 R00667,R02283,R04475 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 SRD1_k127_1549021_1 292459.STH2892 1.679e-101 342.0 COG0002@1|root,COG0002@2|Bacteria,1TPVI@1239|Firmicutes,247R3@186801|Clostridia 186801|Clostridia E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde argC - 1.2.1.38 ko:K00145 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R03443 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC SRD1_k127_1549021_2 760568.Desku_0346 2.516e-82 282.0 COG1364@1|root,COG1364@2|Bacteria,1TPBP@1239|Firmicutes,2497Q@186801|Clostridia,26184@186807|Peptococcaceae 186801|Clostridia E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate argJ - 2.3.1.1,2.3.1.35 ko:K00620 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259,R02282 RC00004,RC00064 ko00000,ko00001,ko00002,ko01000 - - - ArgJ SRD1_k127_1565527_1 880073.Calab_3779 4.717e-58 205.0 COG0149@1|root,COG0149@2|Bacteria,2NP24@2323|unclassified Bacteria 2|Bacteria G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) tpiA GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616 5.3.1.1 ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01015 RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 - - - TIM SRD1_k127_1565527_0 945713.IALB_0349 2.863e-66 251.0 COG3250@1|root,COG3250@2|Bacteria 2|Bacteria G beta-galactosidase activity - - 3.2.1.23 ko:K01190 ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100 - R01105,R01678,R03355,R04783,R06114 RC00049,RC00452 ko00000,ko00001,ko01000 - - - AbfB,DUF2804,DUF4981,Glyco_hydro_106,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N SRD1_k127_1566479_0 883.DvMF_0635 2.636e-57 218.0 COG1975@1|root,COG1975@2|Bacteria,1MXKU@1224|Proteobacteria,42QUY@68525|delta/epsilon subdivisions,2WMVP@28221|Deltaproteobacteria,2M9YK@213115|Desulfovibrionales 28221|Deltaproteobacteria O XdhC and CoxI family - - - ko:K07402 - - - - ko00000 - - - NTP_transf_3,XdhC_C,XdhC_CoxI SRD1_k127_1566479_2 1487921.DP68_16225 6.331e-43 165.0 COG2068@1|root,COG2068@2|Bacteria,1UY6E@1239|Firmicutes,249PV@186801|Clostridia,36FU4@31979|Clostridiaceae 186801|Clostridia S MobA-like NTP transferase domain - - 2.7.7.76 ko:K07141 ko00790,map00790 - R11582 - ko00000,ko00001,ko01000 - - - NTP_transf_3 SRD1_k127_1566479_1 1173024.KI912149_gene6080 1.061e-43 170.0 COG2227@1|root,COG2227@2|Bacteria 2|Bacteria H 3-demethylubiquinone-9 3-O-methyltransferase activity - - 2.1.1.222,2.1.1.64 ko:K00568,ko:K20444 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04988,R05614,R08769,R08781 RC00003,RC00392,RC01895 ko00000,ko00001,ko00002,ko01000,ko01005,ko02000 4.D.1.3 GT2,GT4 - Acyltransferase,MMPL,Methyltransf_13,Methyltransf_14,Methyltransf_23,Methyltransf_31 SRD1_k127_1574207_1 338963.Pcar_3003 6.089e-78 276.0 COG1538@1|root,COG1538@2|Bacteria,1MYXE@1224|Proteobacteria,42TA7@68525|delta/epsilon subdivisions,2WR7T@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Outer membrane efflux protein - - - - - - - - - - - - OEP SRD1_k127_1574207_0 1123054.KB907703_gene1412 1.682e-81 294.0 COG0642@1|root,COG3292@1|root,COG0642@2|Bacteria,COG3292@2|Bacteria,1NXDJ@1224|Proteobacteria,1T1YN@1236|Gammaproteobacteria 1236|Gammaproteobacteria T signal transduction histidine kinase - - - - - - - - - - - - 7TMR-DISMED2,7TMR-DISM_7TM,HATPase_c,HisKA,Hpt,PAS_9,Response_reg SRD1_k127_1578693_0 1047013.AQSP01000139_gene2370 4.114e-226 724.0 COG0383@1|root,COG0383@2|Bacteria,2NNPD@2323|unclassified Bacteria 2|Bacteria G Glycoside hydrolase family 38 central region ams1 - 3.2.1.24 ko:K01191 ko00511,map00511 - - - ko00000,ko00001,ko01000,ko04131 - GH38 - Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C SRD1_k127_1578693_1 243365.CV_2309 2.823e-86 291.0 COG1299@1|root,COG1299@2|Bacteria,1MXFN@1224|Proteobacteria,2VK5D@28216|Betaproteobacteria,2KSKJ@206351|Neisseriales 2|Bacteria G PTS system, fructose subfamily, IIC subunit fruA-1 - 2.7.1.202 ko:K02768,ko:K02769,ko:K02770,ko:K11203 ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060 M00273,M00306 R03232 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.2.1 - - PTS_EIIA_2,PTS_EIIC,PTS_IIB SRD1_k127_1582045_0 1185876.BN8_01430 6.804e-182 596.0 COG0577@1|root,COG0577@2|Bacteria,4NDUK@976|Bacteroidetes,47JJN@768503|Cytophagia 976|Bacteroidetes V FtsX-like permease family - - - - - - - - - - - - FtsX,MacB_PCD SRD1_k127_1582045_1 497964.CfE428DRAFT_4243 1.621e-78 269.0 COG3616@1|root,COG3616@2|Bacteria,46TAP@74201|Verrucomicrobia 74201|Verrucomicrobia E Putative serine dehydratase domain - - - - - - - - - - - - Ala_racemase_N,D-ser_dehydrat SRD1_k127_160263_2 945713.IALB_0942 7.288e-61 228.0 COG2199@1|root,COG2203@1|root,COG2203@2|Bacteria,COG3706@2|Bacteria 2|Bacteria T GGDEF domain pleD - 2.7.13.3 ko:K02478 - - - - ko00000,ko01000,ko01001,ko02022 - - - GAF_2,GGDEF,Response_reg SRD1_k127_160263_0 760568.Desku_1902 1.041e-145 471.0 COG1015@1|root,COG1015@2|Bacteria,1TP70@1239|Firmicutes,247WB@186801|Clostridia,260HR@186807|Peptococcaceae 186801|Clostridia G Phosphotransfer between the C1 and C5 carbon atoms of pentose deoB - 5.4.2.7 ko:K01839 ko00030,ko00230,map00030,map00230 - R01057,R02749 RC00408 ko00000,ko00001,ko01000 - - - Metalloenzyme SRD1_k127_160263_1 1191523.MROS_0180 1.004e-137 442.0 COG0568@1|root,COG0568@2|Bacteria 2|Bacteria K sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released rpoD - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 SRD1_k127_1611835_1 1448860.BBJO01000025_gene3011 9.213e-48 181.0 arCOG02829@1|root,arCOG02829@2157|Archaea,2XT1H@28890|Euryarchaeota,23U4F@183963|Halobacteria 183963|Halobacteria S COG3258 Cytochrome c - - 1.8.2.2 ko:K19713 - - - - ko00000,ko01000 - - - Cytochrom_C SRD1_k127_1611835_0 485918.Cpin_2598 5.88e-67 236.0 COG1416@1|root,COG1416@2|Bacteria,4NH85@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - SRD1_k127_1611835_2 232348.ADXL01000042_gene1621 7.784e-38 154.0 COG0500@1|root,COG2226@2|Bacteria,1G49I@1117|Cyanobacteria,1GZF6@1129|Synechococcus 1117|Cyanobacteria Q Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) - - - - - - - - - - - - Methyltransf_11,Methyltransf_23,Methyltransf_31 SRD1_k127_1618537_0 1191523.MROS_2763 4.628e-124 411.0 COG0247@1|root,COG0247@2|Bacteria 2|Bacteria C lactate metabolic process - - - - - - - - - - - - CCG,Fer4_8 SRD1_k127_1618537_1 517418.Ctha_0717 2.731e-64 233.0 COG0384@1|root,COG0384@2|Bacteria 2|Bacteria S isomerase activity yddE - 5.3.3.17 ko:K06998 ko00405,ko01130,ko02024,map00405,map01130,map02024 M00835 - - ko00000,ko00001,ko00002,ko01000 - - - PhzC-PhzF SRD1_k127_162963_2 1158292.JPOE01000002_gene3435 1.683e-41 166.0 COG4585@1|root,COG4585@2|Bacteria,1MWPN@1224|Proteobacteria,2WEET@28216|Betaproteobacteria 28216|Betaproteobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA_3,PAS,PAS_3,PAS_4,PAS_9,dCache_1 SRD1_k127_162963_1 572547.Amico_1870 2.337e-59 214.0 COG2197@1|root,COG2197@2|Bacteria,3TB23@508458|Synergistetes 508458|Synergistetes K response regulator receiver - - - - - - - - - - - - GerE,Response_reg SRD1_k127_162963_5 945713.IALB_1682 1.139e-10 69.0 COG4980@1|root,COG4980@2|Bacteria 2|Bacteria D gas vesicle protein XK27_07760 - - - - - - - - - - - YtxH SRD1_k127_162963_0 1408473.JHXO01000004_gene224 3.141e-70 244.0 COG2885@1|root,COG2885@2|Bacteria,4NEGF@976|Bacteroidetes,2FNU2@200643|Bacteroidia 976|Bacteroidetes M Belongs to the ompA family - - - - - - - - - - - - Gly-zipper_Omp,OmpA SRD1_k127_162963_3 880073.Calab_1788 4.731e-35 143.0 COG4623@1|root,COG4623@2|Bacteria 2|Bacteria M carbon-oxygen lyase activity, acting on polysaccharides mltF - - ko:K18691 - - - - ko00000,ko01000,ko01011 - - - SBP_bac_3,SLT SRD1_k127_162963_4 404380.Gbem_0454 1.599e-15 77.0 2EFZF@1|root,339RM@2|Bacteria,1NH6S@1224|Proteobacteria,42WYZ@68525|delta/epsilon subdivisions,2WT48@28221|Deltaproteobacteria,43VXN@69541|Desulfuromonadales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - SRD1_k127_1667578_1 926549.KI421517_gene2781 1.448e-85 293.0 COG5434@1|root,COG5434@2|Bacteria,4NG4T@976|Bacteroidetes,47KBB@768503|Cytophagia 976|Bacteroidetes G Belongs to the glycosyl hydrolase 28 family - - - ko:K19172 - - - - ko00000,ko02048 - - - Glyco_hydro_28,Lipase_GDSL_2,Pectate_lyase_3 SRD1_k127_1667578_0 518766.Rmar_2391 7.347e-155 508.0 COG5434@1|root,COG5434@2|Bacteria,4NEM8@976|Bacteroidetes 976|Bacteroidetes G Belongs to the glycosyl hydrolase 28 family - - - - - - - - - - - - Glyco_hydro_28,Glyco_hydro_88,Pectate_lyase_3 SRD1_k127_1674693_0 518766.Rmar_1079 8.583e-265 834.0 COG3661@1|root,COG3661@2|Bacteria,4NHE2@976|Bacteroidetes 976|Bacteroidetes G Belongs to the glycosyl hydrolase 67 family - - 3.2.1.139 ko:K01235 - - - - ko00000,ko01000 - - - Glyco_hydro_67C,Glyco_hydro_67M,Glyco_hydro_67N SRD1_k127_1674693_1 1380600.AUYN01000001_gene2636 8.967e-47 176.0 COG1073@1|root,COG2755@1|root,COG1073@2|Bacteria,COG2755@2|Bacteria,4NG53@976|Bacteroidetes,1I165@117743|Flavobacteriia 976|Bacteroidetes E GDSL-like Lipase/Acylhydrolase family - - - - - - - - - - - - Lipase_GDSL_2,Peptidase_S9 SRD1_k127_1675996_0 306281.AJLK01000180_gene5332 2.021e-153 492.0 COG2183@1|root,COG2183@2|Bacteria,1G12X@1117|Cyanobacteria,1JJ5K@1189|Stigonemataceae 1117|Cyanobacteria L Tex-like protein N-terminal domain - - - ko:K06959 - - - - ko00000 - - - HHH_3,S1,Tex_N,Tex_YqgF SRD1_k127_1675996_1 1123376.AUIU01000012_gene1395 2.545e-29 129.0 COG2887@1|root,COG2887@2|Bacteria 2|Bacteria L Belongs to the helicase family. UvrD subfamily - - - - - - - - - - - - AAA_24,PDDEXK_1 SRD1_k127_1697694_2 1095769.CAHF01000005_gene1456 1.958e-66 231.0 COG0154@1|root,COG0154@2|Bacteria,1MW3Z@1224|Proteobacteria,2VJFS@28216|Betaproteobacteria 28216|Betaproteobacteria J Amidase - - 3.5.1.4 ko:K01426 ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120 - R02540,R03096,R03180,R03909,R05551,R05590 RC00010,RC00100,RC00950,RC01025 ko00000,ko00001,ko01000 - - - Amidase SRD1_k127_1697694_3 485918.Cpin_6203 1.413e-26 118.0 28PRQ@1|root,2ZCDG@2|Bacteria,4NWY7@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - SRD1_k127_1697694_1 1267534.KB906754_gene2572 2.236e-142 464.0 COG1473@1|root,COG1473@2|Bacteria,3Y40E@57723|Acidobacteria,2JIBT@204432|Acidobacteriia 204432|Acidobacteriia S Peptidase dimerisation domain - - - - - - - - - - - - M20_dimer,Peptidase_M20 SRD1_k127_1697694_0 1304872.JAGC01000003_gene3243 1.869e-145 470.0 COG1902@1|root,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,42PDA@68525|delta/epsilon subdivisions,2X5FP@28221|Deltaproteobacteria,2MGQ9@213115|Desulfovibrionales 28221|Deltaproteobacteria C NADH:flavin oxidoreductase / NADH oxidase family - - - - - - - - - - - - Oxidored_FMN SRD1_k127_1698319_6 1122179.KB890436_gene1334 0.0005571 52.0 COG2304@1|root,COG2304@2|Bacteria,4NK2W@976|Bacteroidetes 976|Bacteroidetes M von Willebrand factor, type A - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - OmpA,VIT,VWA,VWA_3 SRD1_k127_1698319_4 156578.ATW7_16892 3.61e-28 126.0 COG3409@1|root,COG3409@2|Bacteria,1RBD0@1224|Proteobacteria,1S2F6@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Putative peptidoglycan binding domain - - - - - - - - - - - - LysM,PG_binding_1 SRD1_k127_1698319_5 1297742.A176_00925 2.474e-17 90.0 2A461@1|root,30SR2@2|Bacteria,1PC3D@1224|Proteobacteria,433A7@68525|delta/epsilon subdivisions,2WXTE@28221|Deltaproteobacteria,2YW5Q@29|Myxococcales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - SRD1_k127_1698319_0 331869.BAL199_01434 7.536e-293 924.0 COG0542@1|root,COG0542@2|Bacteria,1MVBH@1224|Proteobacteria,2TRT7@28211|Alphaproteobacteria,4BTB3@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria O COG0542 ATPases with chaperone activity, ATP-binding subunit - - - ko:K11907 ko02025,ko03070,map02025,map03070 M00334 - - ko00000,ko00001,ko00002,ko02044 3.A.23.1 - - AAA,AAA_2,ClpB_D2-small,Clp_N SRD1_k127_1698319_3 1192034.CAP_5556 4.157e-43 171.0 COG3520@1|root,COG3520@2|Bacteria,1MWVS@1224|Proteobacteria,42Q2Y@68525|delta/epsilon subdivisions,2X3B8@28221|Deltaproteobacteria,2YV7T@29|Myxococcales 28221|Deltaproteobacteria S Type VI secretion, TssG - - - ko:K11895 ko02025,map02025 M00334 - - ko00000,ko00001,ko00002,ko02044 3.A.23.1 - - T6SS_TssG SRD1_k127_1698319_1 1217718.ALOU01000043_gene3987 1.668e-96 332.0 COG3519@1|root,COG3519@2|Bacteria,1MUY4@1224|Proteobacteria,2W0WF@28216|Betaproteobacteria,1KGZ8@119060|Burkholderiaceae 28216|Betaproteobacteria S Type VI secretion system, TssF - - - ko:K11896 - M00334 - - ko00000,ko00002,ko02044 3.A.23.1 - - T6SS_TssF SRD1_k127_1701865_4 224324.aq_2068 3.281e-20 92.0 COG0548@1|root,COG0548@2|Bacteria,2G3SD@200783|Aquificae 200783|Aquificae F Belongs to the acetylglutamate kinase family. ArgB subfamily argB GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.8 ko:K00930 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R02649 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase SRD1_k127_1701865_3 1519464.HY22_11810 1.616e-25 113.0 COG1438@1|root,COG1438@2|Bacteria,1FE1E@1090|Chlorobi 1090|Chlorobi K Regulates arginine biosynthesis genes argR - - ko:K03402 - - - - ko00000,ko03000 - - - Arg_repressor,Arg_repressor_C SRD1_k127_1701865_0 1191523.MROS_0917 1.488e-174 563.0 COG0137@1|root,COG0137@2|Bacteria 2|Bacteria E argininosuccinate synthase activity argG GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 ko:K01940 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418 M00029,M00844,M00845 R01954 RC00380,RC00629 ko00000,ko00001,ko00002,ko01000,ko04147 - - iJN678.argG,iSB619.SA_RS04675 Arginosuc_synth SRD1_k127_1701865_1 292459.STH486 8.348e-154 504.0 COG0165@1|root,COG0165@2|Bacteria,1TNZ6@1239|Firmicutes,2489H@186801|Clostridia 186801|Clostridia E argininosuccinate lyase argH - 4.3.2.1 ko:K01755 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01086 RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ASL_C2,Lyase_1 SRD1_k127_1701865_2 269799.Gmet_1156 1.657e-112 370.0 COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,42MEE@68525|delta/epsilon subdivisions,2WJYV@28221|Deltaproteobacteria,43T22@69541|Desulfuromonadales 28221|Deltaproteobacteria O Belongs to the peptidase M48B family htpX - - ko:K03799 - M00743 - - ko00000,ko00002,ko01000,ko01002 - - - Peptidase_M48 SRD1_k127_1701865_5 945713.IALB_0186 2.424e-18 91.0 COG4675@1|root,COG5276@1|root,COG4675@2|Bacteria,COG5276@2|Bacteria 2|Bacteria M tail collar domain protein - - 3.4.24.40 ko:K01406,ko:K21449 ko01503,map01503 - - - ko00000,ko00001,ko01000,ko01002,ko02000 1.B.40.2 - - Collar,Phage_fiber_2 SRD1_k127_1707587_0 880073.Calab_3794 3.007e-98 338.0 COG2208@1|root,COG2208@2|Bacteria 2|Bacteria T phosphoserine phosphatase activity rsbU - 3.1.3.3,4.6.1.1 ko:K01768,ko:K07315 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000,ko03021 - - - CHASE2,GAF_2,HATPase_c_2,SpoIIE SRD1_k127_1707587_1 1123267.JONN01000001_gene1239 3.939e-32 141.0 2C1YS@1|root,2ZD2Y@2|Bacteria 2|Bacteria S Protease prsW family - - - - - - - - - - - - PrsW-protease SRD1_k127_1707587_2 1123267.JONN01000001_gene1238 1.054e-30 128.0 COG3391@1|root,COG3391@2|Bacteria 2|Bacteria CO amine dehydrogenase activity - - - - - - - - - - - - Cupin_2,MRJP SRD1_k127_1721990_4 43759.JNWK01000091_gene5458 4.101e-24 106.0 COG1167@1|root,COG1167@2|Bacteria,2GITW@201174|Actinobacteria 201174|Actinobacteria EK Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs - - - ko:K05825 ko00300,ko01100,ko01130,ko01210,map00300,map01100,map01130,map01210 - R01939 RC00006 ko00000,ko00001,ko01000 - - - Aminotran_1_2 SRD1_k127_1721990_2 509191.AEDB02000081_gene2501 4.24e-142 462.0 COG1167@1|root,COG1167@2|Bacteria,1TPS5@1239|Firmicutes,248ZB@186801|Clostridia,3WGG5@541000|Ruminococcaceae 186801|Clostridia EK Aminotransferase, class I - - - ko:K05825 ko00300,ko01100,ko01130,ko01210,map00300,map01100,map01130,map01210 - R01939 RC00006 ko00000,ko00001,ko01000 - - - Aminotran_1_2 SRD1_k127_1721990_1 880073.Calab_1564 9.57e-268 842.0 2DBN4@1|root,2ZA1T@2|Bacteria 2|Bacteria S fibronectin type III domain protein - - - - - - - - - - - - - SRD1_k127_1721990_0 880073.Calab_3800 0.0 1276.0 COG1629@1|root,COG1629@2|Bacteria,2NS4U@2323|unclassified Bacteria 2|Bacteria P PFAM TonB-dependent Receptor Plug Domain - - - - - - - - - - - - CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_dep_Rec SRD1_k127_1721990_3 880073.Calab_3803 6.094e-33 130.0 COG2067@1|root,COG2067@2|Bacteria 2|Bacteria I long-chain fatty acid transporting porin activity - - - - - - - - - - - - - SRD1_k127_172572_0 485913.Krac_1655 3.226e-88 302.0 COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria 2|Bacteria L Transposase - - - ko:K07494 - - - - ko00000 - - - DDE_3,HTH_23,HTH_32,HTH_33 SRD1_k127_1727109_0 945713.IALB_3203 1.331e-186 616.0 COG1752@1|root,COG4775@1|root,COG1752@2|Bacteria,COG4775@2|Bacteria 2|Bacteria M membrane organization plpD - - ko:K07001 - - - - ko00000 - - - Bac_surface_Ag,POTRA,Patatin SRD1_k127_1750475_1 1191523.MROS_0058 1.816e-57 213.0 COG2372@1|root,COG2372@2|Bacteria 2|Bacteria C response to copper ion - - - ko:K07156 - - - - ko00000,ko02000 9.B.62.2 - - Big_5,DUF4082,SLH SRD1_k127_1750475_0 945713.IALB_1448 2.094e-66 243.0 COG1559@1|root,COG1559@2|Bacteria 2|Bacteria F Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation mltG - - ko:K07082 - - - - ko00000 - - - YceG SRD1_k127_1750475_2 1089550.ATTH01000001_gene1954 9.703e-24 103.0 COG0533@1|root,COG0533@2|Bacteria,4NE8E@976|Bacteroidetes,1FIMF@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction tsaD GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360 2.3.1.234 ko:K01409 - - R10648 RC00070,RC00416 ko00000,ko01000,ko03016 - - - Peptidase_M22 SRD1_k127_1758485_2 1183438.GKIL_4241 1.183e-60 218.0 COG0363@1|root,COG0363@2|Bacteria,1G20H@1117|Cyanobacteria 1117|Cyanobacteria G 6-phosphogluconolactonase pgl GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009051,GO:0009117,GO:0009987,GO:0016787,GO:0016788,GO:0017057,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0052689,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564 3.1.1.31 ko:K01057 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200 M00004,M00006,M00008 R02035 RC00537 ko00000,ko00001,ko00002,ko01000 - - - Glucosamine_iso SRD1_k127_1758485_7 321332.CYB_2873 1.703e-33 131.0 COG2154@1|root,COG2154@2|Bacteria,1G7P9@1117|Cyanobacteria,1H11A@1129|Synechococcus 1117|Cyanobacteria H pterin-4-alpha-carbinolamine dehydratase phhB - 4.2.1.96 ko:K01724 ko00790,map00790 - R04734 RC01208 ko00000,ko00001,ko01000,ko04147 - - - Pterin_4a SRD1_k127_1758485_3 1297742.A176_06331 3.081e-44 168.0 COG3386@1|root,COG3386@2|Bacteria,1NFEJ@1224|Proteobacteria,43BX0@68525|delta/epsilon subdivisions,2X77S@28221|Deltaproteobacteria,2YVY8@29|Myxococcales 28221|Deltaproteobacteria G PFAM SMP-30 Gluconolaconase - - - - - - - - - - - - - SRD1_k127_1758485_5 700598.Niako_4917 6.012e-42 166.0 COG0671@1|root,COG0671@2|Bacteria,4NF34@976|Bacteroidetes,1IY3J@117747|Sphingobacteriia 976|Bacteroidetes I PAP2 superfamily - - - - - - - - - - - - PAP2 SRD1_k127_1758485_4 1123248.KB893359_gene2037 2.23e-42 171.0 COG0671@1|root,COG0671@2|Bacteria,4NF34@976|Bacteroidetes,1IY3J@117747|Sphingobacteriia 976|Bacteroidetes I PAP2 superfamily - - - - - - - - - - - - PAP2 SRD1_k127_1758485_0 761193.Runsl_3418 3.221e-298 947.0 COG3696@1|root,COG3696@2|Bacteria,4P36A@976|Bacteroidetes,47N0F@768503|Cytophagia 976|Bacteroidetes P AcrB/AcrD/AcrF family - - - ko:K15726 - - - - ko00000,ko02000 2.A.6.1.2 - - ACR_tran SRD1_k127_1758485_6 977880.RALTA_B0379 7.403e-35 147.0 COG0845@1|root,COG0845@2|Bacteria,1R4E4@1224|Proteobacteria,2VN9E@28216|Betaproteobacteria,1K92Y@119060|Burkholderiaceae 28216|Betaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K15727 - - - - ko00000,ko02000 8.A.1.2.1 - - HlyD_D23 SRD1_k127_1758485_9 391596.PBAL39_13095 1.193e-25 121.0 COG1538@1|root,COG1538@2|Bacteria,4NHEA@976|Bacteroidetes,1IPXQ@117747|Sphingobacteriia 976|Bacteroidetes MU outer membrane efflux protein czcC - - ko:K15725 - - - - ko00000,ko02000 1.B.17.2.2 - - OEP SRD1_k127_1758485_8 1121899.Q764_07650 8.706e-30 130.0 COG5544@1|root,COG5544@2|Bacteria,4NGNB@976|Bacteroidetes,1HZYF@117743|Flavobacteriia,2NTPA@237|Flavobacterium 976|Bacteroidetes S Predicted periplasmic lipoprotein (DUF2279) - - - - - - - - - - - - DUF2279 SRD1_k127_1758485_1 1121957.ATVL01000007_gene2058 4.023e-126 414.0 COG2017@1|root,COG2017@2|Bacteria,4NF5G@976|Bacteroidetes,47KAR@768503|Cytophagia 976|Bacteroidetes G Converts alpha-aldose to the beta-anomer - - 5.1.3.3 ko:K01785 ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130 M00632 R01602,R10619 RC00563 ko00000,ko00001,ko00002,ko01000 - - - Aldose_epim SRD1_k127_1771297_1 502025.Hoch_6664 9.757e-138 468.0 COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,433Y1@68525|delta/epsilon subdivisions,2X41I@28221|Deltaproteobacteria,2YXYJ@29|Myxococcales 28221|Deltaproteobacteria S Insulinase (Peptidase family M16) - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C SRD1_k127_1771297_0 926550.CLDAP_34530 9.179e-165 523.0 COG0667@1|root,COG0667@2|Bacteria,2G681@200795|Chloroflexi 200795|Chloroflexi C Aldo/keto reductase family - - - ko:K19265 - - - - ko00000,ko01000 - - - Aldo_ket_red SRD1_k127_1771297_2 760011.Spico_0116 2.333e-32 135.0 COG0705@1|root,COG0705@2|Bacteria,2J7HV@203691|Spirochaetes 203691|Spirochaetes S PFAM Rhomboid family - - - - - - - - - - - - Rhomboid SRD1_k127_1795117_1 1173027.Mic7113_3540 7.737e-21 96.0 COG1669@1|root,COG1669@2|Bacteria,1G8U6@1117|Cyanobacteria,1HCKC@1150|Oscillatoriales 1117|Cyanobacteria S Nucleotidyltransferase domain - - - ko:K07075 - - - - ko00000 - - - NTP_transf_2 SRD1_k127_1795117_0 686340.Metal_2762 4.06e-91 313.0 COG3385@1|root,COG3385@2|Bacteria,1QFKR@1224|Proteobacteria,1SCE4@1236|Gammaproteobacteria,1XGSH@135618|Methylococcales 135618|Methylococcales L transposase activity - - - - - - - - - - - - - SRD1_k127_1803971_1 883126.HMPREF9710_02008 6.49e-73 251.0 COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,2VI71@28216|Betaproteobacteria,472DU@75682|Oxalobacteraceae 28216|Betaproteobacteria P Phosphate transporter family pit - - ko:K03306 - - - - ko00000 2.A.20 - - PHO4 SRD1_k127_1803971_5 316067.Geob_1765 2.838e-26 111.0 COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,42V0K@68525|delta/epsilon subdivisions 1224|Proteobacteria K PFAM Cold-shock protein, DNA-binding cspA - - ko:K03704 - - - - ko00000,ko03000 - - - CSD SRD1_k127_1803971_4 269799.Gmet_3259 1.382e-50 192.0 COG0124@1|root,COG0124@2|Bacteria,1QXPM@1224|Proteobacteria,42S0A@68525|delta/epsilon subdivisions,2WNBC@28221|Deltaproteobacteria,43UFK@69541|Desulfuromonadales 28221|Deltaproteobacteria J Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine hisZ - - ko:K02502 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002 - - - HGTP_anticodon,tRNA-synt_His SRD1_k127_1803971_3 273068.TTE2139 8.355e-52 192.0 COG0040@1|root,COG0040@2|Bacteria,1TSVZ@1239|Firmicutes,249AR@186801|Clostridia,42G66@68295|Thermoanaerobacterales 186801|Clostridia F Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity hisG - 2.4.2.17 ko:K00765,ko:K02502 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002,ko01000 - - - HisG SRD1_k127_1803971_0 1123290.AUDQ01000002_gene2287 3.852e-121 402.0 COG0141@1|root,COG0141@2|Bacteria,1TPAW@1239|Firmicutes,4H9XK@91061|Bacilli,26E53@186818|Planococcaceae 91061|Bacilli E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine hisD - 1.1.1.23 ko:K00013 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01158,R01163,R03012 RC00099,RC00242,RC00463 ko00000,ko00001,ko00002,ko01000 - - - Histidinol_dh SRD1_k127_1803971_2 1121430.JMLG01000005_gene776 8.858e-73 259.0 COG0079@1|root,COG0079@2|Bacteria,1TPUV@1239|Firmicutes,24837@186801|Clostridia,2606W@186807|Peptococcaceae 186801|Clostridia E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily hisC GO:0003674,GO:0003824,GO:0008110,GO:0008483,GO:0016740,GO:0016769 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 SRD1_k127_1803971_6 344747.PM8797T_05825 7.782e-16 83.0 COG0131@1|root,COG0131@2|Bacteria,2IYU4@203682|Planctomycetes 203682|Planctomycetes E imidazoleglycerol-phosphate dehydratase hisB GO:0000105,GO:0003674,GO:0003824,GO:0004424,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.19 ko:K01693 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R03457 RC00932 ko00000,ko00001,ko00002,ko01000 - - - IGPD SRD1_k127_1813512_1 518766.Rmar_2397 3.371e-194 623.0 28KE7@1|root,2ZA0G@2|Bacteria,4P0D4@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - SRD1_k127_1813512_0 518766.Rmar_2398 0.0 1042.0 COG1629@1|root,COG4771@2|Bacteria 2|Bacteria P TonB-dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,CarboxypepD_reg,OMP_b-brl_3,Plug,TonB_dep_Rec SRD1_k127_1813512_2 880073.Calab_3215 1.93e-20 93.0 COG0366@1|root,COG0708@1|root,COG0366@2|Bacteria,COG0708@2|Bacteria,2NREA@2323|unclassified Bacteria 2|Bacteria G Glycosyl hydrolase family 70 - - 3.1.11.2,3.2.1.1 ko:K01142,ko:K01176 ko00500,ko01100,ko03410,ko04973,map00500,map01100,map03410,map04973 - R02108,R02112,R11262 - ko00000,ko00001,ko01000,ko03400 - GH13 - Alpha-amylase,CBM_25,DUF1939,He_PIG SRD1_k127_1834421_4 479435.Kfla_1069 5.02e-17 88.0 COG2366@1|root,COG2366@2|Bacteria,2GKEN@201174|Actinobacteria,4DPY6@85009|Propionibacteriales 201174|Actinobacteria S Penicillin amidase pacB3 - - - - - - - - - - - F5_F8_type_C,Penicil_amidase SRD1_k127_1834421_1 880073.Calab_1886 1.112e-104 354.0 COG3876@1|root,COG3876@2|Bacteria,2NNRQ@2323|unclassified Bacteria 2|Bacteria S PFAM Uncharacterised conserved protein UCP016719 - - - - - - - - - - - - DUF1343 SRD1_k127_1834421_2 1047013.AQSP01000125_gene2621 1.953e-102 351.0 COG0591@1|root,COG0591@2|Bacteria 2|Bacteria E symporter activity - - - ko:K03307 - - - - ko00000 2.A.21 - - SSF SRD1_k127_1834421_0 768670.Calni_0263 5.265e-110 368.0 COG0738@1|root,COG0738@2|Bacteria 2|Bacteria G Major facilitator superfamily - - 2.3.1.40,6.2.1.20 ko:K05939,ko:K18214 ko00071,ko00564,map00071,map00564 - R01406,R04864 RC00014,RC00039,RC00041 ko00000,ko00001,ko01000,ko01504,ko02000 2.A.1.21.6 - - MFS_1,MFS_1_like SRD1_k127_1834421_3 56110.Oscil6304_2815 2.618e-81 296.0 COG1404@1|root,COG1520@1|root,COG2931@1|root,COG4733@1|root,COG4935@1|root,COG1404@2|Bacteria,COG1520@2|Bacteria,COG2931@2|Bacteria,COG4733@2|Bacteria,COG4935@2|Bacteria,1G342@1117|Cyanobacteria,1HH6R@1150|Oscillatoriales 1117|Cyanobacteria O Beta-propeller repeat - - - - - - - - - - - - Calx-beta,DUF4114,P_proprotein,Peptidase_S8,SBBP SRD1_k127_1840009_3 288000.BBta_0641 9.833e-22 96.0 2C3U2@1|root,30RRG@2|Bacteria,1RGFH@1224|Proteobacteria,2USYI@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - SRD1_k127_1840009_0 521460.Athe_0061 2.434e-60 222.0 COG1216@1|root,COG1216@2|Bacteria,1UYRR@1239|Firmicutes,249T1@186801|Clostridia,42HAT@68295|Thermoanaerobacterales 186801|Clostridia M PFAM Glycosyl transferase family 2 - - - ko:K07011,ko:K20444 - - - - ko00000,ko01000,ko01005,ko02000 4.D.1.3 GT2,GT4 - Glyco_tranf_2_3,Glyco_trans_2_3,Glycos_transf_2,Methyltransf_23 SRD1_k127_1840009_1 1453500.AT05_04760 2.802e-33 143.0 COG0438@1|root,COG0438@2|Bacteria,4NFD3@976|Bacteroidetes,1HX3M@117743|Flavobacteriia 976|Bacteroidetes M glycosyltransferase - - - - - - - - - - - - Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4 SRD1_k127_1840009_2 518766.Rmar_2624 3.691e-22 108.0 COG1596@1|root,COG1596@2|Bacteria,4P33T@976|Bacteroidetes 976|Bacteroidetes M Polysaccharide biosynthesis/export protein - - - - - - - - - - - - Poly_export,SLBB SRD1_k127_1841859_2 509190.Cseg_2814 3.144e-10 63.0 COG0414@1|root,COG0414@2|Bacteria,1MV1S@1224|Proteobacteria,2TS2D@28211|Alphaproteobacteria,2KFAU@204458|Caulobacterales 204458|Caulobacterales H Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate panC - 6.3.2.1 ko:K01918 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R02473 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_ligase SRD1_k127_1841859_0 1191523.MROS_2414 1.67e-122 398.0 COG0777@1|root,COG0777@2|Bacteria 2|Bacteria I Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA accD GO:0001676,GO:0003674,GO:0003676,GO:0003677,GO:0003723,GO:0003729,GO:0003824,GO:0003989,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006417,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008270,GO:0008610,GO:0009058,GO:0009317,GO:0009329,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016053,GO:0016421,GO:0016874,GO:0016885,GO:0017148,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032787,GO:0032991,GO:0034248,GO:0034249,GO:0042759,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:0097159,GO:1901363,GO:1901576,GO:1902494,GO:1990234,GO:2000112,GO:2000113 2.1.3.15,6.4.1.2 ko:K01963 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - iJN678.accD,iPC815.YPO2768,iUTI89_1310.UTI89_C2601 Carboxyl_trans SRD1_k127_1841859_1 500635.MITSMUL_03431 1.612e-15 84.0 COG1214@1|root,COG1214@2|Bacteria,1V4YX@1239|Firmicutes,4H47Z@909932|Negativicutes 909932|Negativicutes O Universal bacterial protein YeaZ yeaZ - - ko:K14742 - - - - ko00000,ko03016 - - - Peptidase_M22 SRD1_k127_1860981_0 1379698.RBG1_1C00001G0607 2.628e-179 588.0 COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2NQNE@2323|unclassified Bacteria 2|Bacteria T Serine threonine protein kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PASTA,Pkinase,TPR_2,TPR_8 SRD1_k127_1860981_1 526227.Mesil_0296 1.983e-40 153.0 COG0640@1|root,COG3860@1|root,COG0640@2|Bacteria,COG3860@2|Bacteria,1WN7K@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus K Uncharacterized protein conserved in bacteria (DUF2087) - - - - - - - - - - - - DUF2087 SRD1_k127_1868387_0 945713.IALB_2161 1.662e-63 234.0 COG4206@1|root,COG4206@2|Bacteria 2|Bacteria H cobalamin-transporting ATPase activity - - - ko:K02014,ko:K16092 - - - - ko00000,ko02000 1.B.14,1.B.14.3 - - CarbopepD_reg_2,Plug,TonB_dep_Rec SRD1_k127_1868387_1 1121904.ARBP01000001_gene5465 8.198e-46 182.0 COG3595@1|root,COG3595@2|Bacteria,4NJCC@976|Bacteroidetes,47MIA@768503|Cytophagia 976|Bacteroidetes - - - - - - - - - - - - - - DUF4097 SRD1_k127_1868387_4 204669.Acid345_4526 6.623e-19 98.0 COG1413@1|root,COG5662@1|root,COG1413@2|Bacteria,COG5662@2|Bacteria,3Y2TB@57723|Acidobacteria,2JHKS@204432|Acidobacteriia 204432|Acidobacteriia C HEAT repeats - - - - - - - - - - - - HEAT_2,zf-HC2 SRD1_k127_1868387_2 204669.Acid345_4527 4.101e-31 133.0 COG1595@1|root,COG1595@2|Bacteria,3Y4CH@57723|Acidobacteria,2JJ6R@204432|Acidobacteriia 204432|Acidobacteriia K TIGRFAM RNA polymerase sigma factor, sigma-70 family - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4,Sigma70_r4_2 SRD1_k127_1868387_3 309807.SRU_1662 7.167e-31 132.0 COG0147@1|root,COG0147@2|Bacteria,4NFQ5@976|Bacteroidetes,1FIRE@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes EH Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia trpE - 4.1.3.27 ko:K01657 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Anth_synt_I_N,Chorismate_bind SRD1_k127_1869473_1 1382359.JIAL01000001_gene872 1.431e-138 447.0 COG0154@1|root,COG0154@2|Bacteria,3Y2PE@57723|Acidobacteria,2JIE0@204432|Acidobacteriia 204432|Acidobacteriia J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) gatA - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase SRD1_k127_1869473_0 517418.Ctha_2680 3.032e-142 458.0 COG0074@1|root,COG0074@2|Bacteria,1FD8P@1090|Chlorobi 1090|Chlorobi C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit sucD - 6.2.1.5 ko:K01902 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - CoA_binding,Ligase_CoA SRD1_k127_1869473_3 518766.Rmar_2216 2.143e-56 201.0 COG0105@1|root,COG0105@2|Bacteria,4NM5B@976|Bacteroidetes,1FJES@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes F Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate ndk - 2.7.4.6 ko:K00940 ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016 M00049,M00050,M00052,M00053 R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895 RC00002 ko00000,ko00001,ko00002,ko01000,ko04131 - - - NDK SRD1_k127_1869473_4 1183438.GKIL_0303 2.669e-37 147.0 COG0494@1|root,COG0494@2|Bacteria,1GFG0@1117|Cyanobacteria 1117|Cyanobacteria L COG494 NTP pyrophosphohydrolases including oxidative damage repair enzymes DNA replication, recombination, and repair General function prediction only - - 3.6.1.13 ko:K01515 ko00230,map00230 - R01054 RC00002 ko00000,ko00001,ko01000 - - - NUDIX SRD1_k127_1869473_2 518766.Rmar_2217 1.043e-112 376.0 COG3876@1|root,COG3876@2|Bacteria,4NEXD@976|Bacteroidetes,1FJZG@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S Protein of unknown function (DUF1343) - - - - - - - - - - - - DUF1343 SRD1_k127_1877837_3 1463887.KL590026_gene2103 6.263e-45 177.0 COG1129@1|root,COG1129@2|Bacteria,2GJ3F@201174|Actinobacteria 201174|Actinobacteria G Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system - - 3.6.3.17 ko:K10539 ko02010,map02010 M00213 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.2.2 - - ABC_tran SRD1_k127_1877837_0 1121957.ATVL01000007_gene1534 8.137e-248 774.0 COG2407@1|root,COG2407@2|Bacteria,4NGB6@976|Bacteroidetes,47TSI@768503|Cytophagia 976|Bacteroidetes G Pfam L-fucose isomerase, C-terminal domain - - - - - - - - - - - - Fucose_iso_C SRD1_k127_1877837_2 1047013.AQSP01000133_gene2137 1.752e-117 387.0 COG1172@1|root,COG1172@2|Bacteria,2NPUE@2323|unclassified Bacteria 2|Bacteria U Branched-chain amino acid transport system / permease component - - - ko:K02057 - M00221 - - ko00000,ko00002,ko02000 3.A.1.2 - - BPD_transp_2 SRD1_k127_1877837_1 1499967.BAYZ01000173_gene5799 6.485e-138 447.0 COG1879@1|root,COG1879@2|Bacteria,2NQCX@2323|unclassified Bacteria 2|Bacteria G Periplasmic binding protein domain - - - - - - - - - - - - Peripla_BP_4 SRD1_k127_1883508_2 1002367.HMPREF0673_01416 4.494e-68 236.0 COG0157@1|root,COG0157@2|Bacteria,4NDXF@976|Bacteroidetes,2FMJM@200643|Bacteroidia 976|Bacteroidetes H Belongs to the NadC ModD family nadC - 2.4.2.19 ko:K00767 ko00760,ko01100,map00760,map01100 M00115 R03348 RC02877 ko00000,ko00001,ko00002,ko01000 - - - QRPTase_C,QRPTase_N SRD1_k127_1883508_0 945713.IALB_0750 1.382e-131 437.0 COG2244@1|root,COG2244@2|Bacteria 2|Bacteria S polysaccharide biosynthetic process cap - - - - - - - - - - - Polysacc_synt,Polysacc_synt_3,Polysacc_synt_C SRD1_k127_1883508_1 880073.Calab_1927 4.113e-78 272.0 COG3872@1|root,COG3872@2|Bacteria,2NP59@2323|unclassified Bacteria 2|Bacteria S Protein of unknown function (DUF1385) prmC - - ko:K09153 - - - - ko00000 - - - DUF1385 SRD1_k127_1913877_0 471854.Dfer_4313 1.166e-136 454.0 COG0546@1|root,COG2870@1|root,COG0546@2|Bacteria,COG2870@2|Bacteria,4NJ8F@976|Bacteroidetes,47MRA@768503|Cytophagia 976|Bacteroidetes M pfkB family carbohydrate kinase - - - - - - - - - - - - Hydrolase,PfkB SRD1_k127_1913877_1 1304865.JAGF01000001_gene2360 1.348e-60 221.0 COG0395@1|root,COG0395@2|Bacteria,2GJ5X@201174|Actinobacteria 201174|Actinobacteria G Binding-protein-dependent transport systems inner membrane component - - - - - - - - - - - - BPD_transp_1 SRD1_k127_1913877_2 1499968.TCA2_4355 1.34e-13 72.0 COG1175@1|root,COG1175@2|Bacteria,1TTAF@1239|Firmicutes,4HBIM@91061|Bacilli,26W9S@186822|Paenibacillaceae 91061|Bacilli G Binding-protein-dependent transport system inner membrane component - - - ko:K02025 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 SRD1_k127_1938990_1 945713.IALB_0893 8.381e-103 338.0 COG1034@1|root,COG3383@1|root,COG1034@2|Bacteria,COG3383@2|Bacteria 2|Bacteria C formate dehydrogenase (NAD+) activity nuoG - 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer2_4,Fer4,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 SRD1_k127_1938990_0 903818.KI912269_gene239 3.365e-140 457.0 COG0436@1|root,COG0436@2|Bacteria,3Y5C9@57723|Acidobacteria 57723|Acidobacteria E Aminotransferase class I and II - - 2.6.1.2,2.6.1.66 ko:K14260 ko00220,ko00250,ko00290,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00290,map01100,map01110,map01130,map01210,map01230 - R00258,R01215 RC00006,RC00008,RC00036 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 SRD1_k127_194431_11 1122176.KB903544_gene724 1.03e-09 61.0 COG0327@1|root,COG0327@2|Bacteria,4NF51@976|Bacteroidetes,1IX76@117747|Sphingobacteriia 976|Bacteroidetes S NIF3 (NGG1p interacting factor 3) yqfO - - - - - - - - - - - NIF3 SRD1_k127_194431_5 945713.IALB_0319 1.462e-56 207.0 COG1579@1|root,COG1579@2|Bacteria 2|Bacteria - - CP_0228 - 3.5.4.16 ko:K07164,ko:K22391 ko00790,ko01100,map00790,map01100 M00126 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - - zf-RING_7 SRD1_k127_194431_9 867903.ThesuDRAFT_00795 8.079e-30 128.0 COG0328@1|root,COG2384@1|root,COG0328@2|Bacteria,COG2384@2|Bacteria,1V3I4@1239|Firmicutes,24BJI@186801|Clostridia,3WDGE@538999|Clostridiales incertae sedis 186801|Clostridia L tRNA (adenine(22)-N(1))-methyltransferase trmK - 2.1.1.217 ko:K06967 - - - - ko00000,ko01000,ko03016 - - - Methyltransf_18,TrmK SRD1_k127_194431_0 1191523.MROS_0746 1.134e-187 605.0 COG0608@1|root,COG0608@2|Bacteria 2|Bacteria L single-stranded DNA 5'-3' exodeoxyribonuclease activity recJ - - ko:K07462 ko03410,ko03430,ko03440,map03410,map03430,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1 SRD1_k127_194431_4 1379698.RBG1_1C00001G0835 2.236e-94 319.0 COG0217@1|root,COG0217@2|Bacteria,2NNSI@2323|unclassified Bacteria 2|Bacteria K Transcriptional regulatory protein yebC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - - - - - - - - - - Transcrip_reg SRD1_k127_194431_7 945713.IALB_0316 1.788e-50 184.0 COG0817@1|root,COG0817@2|Bacteria 2|Bacteria L Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group ruvC GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009987,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576 3.1.22.4 ko:K01159 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvC SRD1_k127_194431_8 517418.Ctha_0592 1.596e-45 176.0 COG0632@1|root,COG0632@2|Bacteria,1FE0R@1090|Chlorobi 1090|Chlorobi L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB ruvA - 3.6.4.12 ko:K03550 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - HHH_5,RuvA_C,RuvA_N SRD1_k127_194431_2 525373.HMPREF0766_14046 8.769e-131 426.0 COG2255@1|root,COG2255@2|Bacteria,4NEB9@976|Bacteroidetes,1IR3Y@117747|Sphingobacteriia 976|Bacteroidetes L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing ruvB - 3.6.4.12 ko:K03551 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvB_C,RuvB_N SRD1_k127_194431_6 945713.IALB_0617 2.3e-53 196.0 COG2094@1|root,COG2094@2|Bacteria 2|Bacteria L Belongs to the DNA glycosylase MPG family mpg GO:0003674,GO:0003824,GO:0003905,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 3.2.2.21 ko:K03652 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Pur_DNA_glyco SRD1_k127_194431_10 880073.Calab_2081 2.003e-20 108.0 COG3291@1|root,COG5276@1|root,COG3291@2|Bacteria,COG5276@2|Bacteria,2NQ2P@2323|unclassified Bacteria 2|Bacteria P LVIVD repeat - - 3.2.1.4 ko:K01179 ko00500,ko01100,map00500,map01100 - R06200,R11307,R11308 - ko00000,ko00001,ko01000 - GH5,GH9 - LVIVD SRD1_k127_194431_1 1233950.IW22_01405 4.538e-132 454.0 COG1404@1|root,COG3391@1|root,COG1404@2|Bacteria,COG3391@2|Bacteria,4PHUC@976|Bacteroidetes,1ICV1@117743|Flavobacteriia,3ZSG6@59732|Chryseobacterium 976|Bacteroidetes O Subtilase family - - - - - - - - - - - - Peptidase_S8 SRD1_k127_194431_3 1519464.HY22_06660 2.273e-101 344.0 COG4447@1|root,COG4447@2|Bacteria 2|Bacteria S cellulose binding - - - - - - - - - - - - FlgD_ig,MAM,Sortilin-Vps10,TIG,fn3 SRD1_k127_1952112_0 1358423.N180_12255 8.038e-146 471.0 COG4948@1|root,COG4948@2|Bacteria,4NG8N@976|Bacteroidetes,1IQ9P@117747|Sphingobacteriia 976|Bacteroidetes M Mandelate racemase muconate lactonizing enzyme ykfB GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016854,GO:0034641,GO:0043167,GO:0043169,GO:0043603,GO:0044237,GO:0046872,GO:0071704,GO:1901564 5.1.1.20,5.1.1.3 ko:K01776,ko:K19802 ko00471,ko01100,map00471,map01100 - R00260,R10938 RC00302,RC03309 ko00000,ko00001,ko01000,ko01011 - - - MR_MLE_C,MR_MLE_N SRD1_k127_1952112_1 945713.IALB_0983 6.522e-46 179.0 COG4299@1|root,COG4299@2|Bacteria 2|Bacteria G COGs COG4299 conserved - - - - - - - - - - - - DUF1624,DUF5009 SRD1_k127_1953934_1 402880.MmarC5_1594 7.13e-07 62.0 COG0840@1|root,arCOG02320@2157|Archaea,2XTG0@28890|Euryarchaeota,23RJI@183939|Methanococci 183939|Methanococci N PFAM histidine kinase, HAMP region domain protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,sCache_3_3 SRD1_k127_1953934_0 1191523.MROS_0619 1.117e-240 758.0 COG1022@1|root,COG1022@2|Bacteria 2|Bacteria I Amp-dependent synthetase and ligase - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding SRD1_k127_2001238_2 1123277.KB893177_gene3511 1.656e-41 166.0 COG1409@1|root,COG1409@2|Bacteria,4NECQ@976|Bacteroidetes,47N3U@768503|Cytophagia 976|Bacteroidetes S Calcineurin-like phosphoesterase - - - - - - - - - - - - Metallophos SRD1_k127_2001238_0 880073.Calab_1151 8.928e-204 659.0 COG1629@1|root,COG4771@2|Bacteria 2|Bacteria P TonB-dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - CarbopepD_reg_2,Plug,TonB_dep_Rec SRD1_k127_2001238_3 1265505.ATUG01000001_gene3512 3.419e-24 111.0 COG1564@1|root,COG1564@2|Bacteria,1REBP@1224|Proteobacteria,42RVH@68525|delta/epsilon subdivisions,2WNW0@28221|Deltaproteobacteria,2MK01@213118|Desulfobacterales 28221|Deltaproteobacteria H Thiamin pyrophosphokinase, vitamin B1 binding domain - - 2.7.6.2 ko:K00949 ko00730,ko01100,map00730,map01100 - R00619 RC00002,RC00017 ko00000,ko00001,ko01000 - - - TPK_B1_binding,TPK_catalytic SRD1_k127_2001238_1 945713.IALB_1748 5.482e-107 362.0 COG0591@1|root,COG0591@2|Bacteria 2|Bacteria E symporter activity - - - ko:K03307 - - - - ko00000 2.A.21 - - SSF SRD1_k127_2009105_0 877455.Metbo_0048 2.594e-121 397.0 COG0477@1|root,arCOG02682@2157|Archaea,2XWP6@28890|Euryarchaeota,23PB6@183925|Methanobacteria 183925|Methanobacteria G Sugar (and other) transporter - - - - - - - - - - - - - SRD1_k127_2009105_1 1191523.MROS_2608 1.95e-115 382.0 COG1609@1|root,COG1609@2|Bacteria 2|Bacteria K purine nucleotide biosynthetic process - - - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_1,Peripla_BP_3 SRD1_k127_2009105_2 1122194.AUHU01000007_gene201 4.64e-96 319.0 COG1904@1|root,COG1904@2|Bacteria,1MVRI@1224|Proteobacteria,1RMRR@1236|Gammaproteobacteria,464VQ@72275|Alteromonadaceae 1236|Gammaproteobacteria G Glucuronate isomerase uxaC GO:0005975,GO:0005996,GO:0006063,GO:0006064,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0019585,GO:0019586,GO:0019698,GO:0019752,GO:0032787,GO:0042839,GO:0042840,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046365,GO:0046395,GO:0046396,GO:0046397,GO:0071704,GO:0072329,GO:1901575 5.3.1.12 ko:K01812 ko00040,ko01100,map00040,map01100 M00061,M00631 R01482,R01983 RC00376 ko00000,ko00001,ko00002,ko01000 - - iPC815.YPO0579,iSbBS512_1146.SbBS512_E3528 UxaC SRD1_k127_2010849_4 1191523.MROS_0329 9.972e-18 85.0 COG0860@1|root,COG0860@2|Bacteria 2|Bacteria M N-Acetylmuramoyl-L-alanine amidase cwlM GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - Amidase_3,PG_binding_1 SRD1_k127_2010849_3 794903.OPIT5_07595 1.023e-32 139.0 COG2971@1|root,COG2971@2|Bacteria,46SJI@74201|Verrucomicrobia,3K9UB@414999|Opitutae 414999|Opitutae G BadF/BadG/BcrA/BcrD ATPase family - - - - - - - - - - - - BcrAD_BadFG SRD1_k127_2010849_0 518766.Rmar_0925 5.841e-213 694.0 COG1472@1|root,COG1680@1|root,COG1472@2|Bacteria,COG1680@2|Bacteria,4NET8@976|Bacteroidetes,1FJ9E@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes G Glycosyl hydrolase family 3 N terminal domain - - 3.2.1.52 ko:K01207 ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501 M00628 R00022,R05963,R07809,R07810,R10831 RC00049 ko00000,ko00001,ko00002,ko01000 - - - Beta-lactamase,Glyco_hydro_3,Glyco_hydro_3_C SRD1_k127_2010849_2 234267.Acid_1106 1.162e-52 192.0 COG0586@1|root,COG0586@2|Bacteria,3Y7W0@57723|Acidobacteria 57723|Acidobacteria S SNARE associated Golgi protein - - - - - - - - - - - - SNARE_assoc SRD1_k127_2010849_5 255470.cbdbA218 2.759e-15 83.0 COG1413@1|root,COG1413@2|Bacteria,2GAT7@200795|Chloroflexi,34DAH@301297|Dehalococcoidia 301297|Dehalococcoidia C HEAT repeats - - - - - - - - - - - - HEAT_2 SRD1_k127_2010849_1 1459636.NTE_01731 5.158e-69 256.0 arCOG00567@1|root,arCOG00567@2157|Archaea 2157|Archaea S glycosyl transferase family - - 2.4.99.18 ko:K07151 ko00510,ko00513,ko01100,ko04141,map00510,map00513,map01100,map04141 M00072 R04216,R05976 RC00005,RC00482 ko00000,ko00001,ko00002,ko01000,ko01003 - GT66 - PMT_2 SRD1_k127_2025316_0 382464.ABSI01000010_gene3514 1.326e-220 704.0 28MYJ@1|root,2ZB5F@2|Bacteria,46U0W@74201|Verrucomicrobia 74201|Verrucomicrobia - - - - - - - - - - - - - - - SRD1_k127_2025316_1 313628.LNTAR_08634 3.108e-68 239.0 COG1028@1|root,COG1028@2|Bacteria 313628.LNTAR_08634|- IQ oxidoreductase activity, acting on CH-OH group of donors - - - - - - - - - - - - - SRD1_k127_2031901_1 945713.IALB_1310 3.122e-83 287.0 COG3829@1|root,COG4191@1|root,COG3829@2|Bacteria,COG4191@2|Bacteria 2|Bacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg SRD1_k127_2031901_3 313628.LNTAR_05511 4.75e-57 214.0 COG2265@1|root,COG2265@2|Bacteria 2|Bacteria J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family - - - - - - - - - - - - tRNA_U5-meth_tr SRD1_k127_2031901_2 204669.Acid345_2745 3.215e-77 264.0 COG2173@1|root,COG2173@2|Bacteria,3Y4BY@57723|Acidobacteria,2JKFC@204432|Acidobacteriia 204432|Acidobacteriia M D-ala-D-ala dipeptidase - - 3.4.13.22 ko:K08641 ko01502,ko02020,map01502,map02020 M00651 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504 - - - Peptidase_M15 SRD1_k127_2031901_0 383372.Rcas_3540 2.725e-83 286.0 COG0855@1|root,COG0855@2|Bacteria,2G68J@200795|Chloroflexi,374Y0@32061|Chloroflexia 32061|Chloroflexia H Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) ppk - 2.7.4.1 ko:K00937 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PP_kinase,PP_kinase_C,PP_kinase_N SRD1_k127_2032494_0 1408473.JHXO01000006_gene1118 5.391e-169 544.0 COG1070@1|root,COG1070@2|Bacteria,4NFBZ@976|Bacteroidetes,2FPIS@200643|Bacteroidia 976|Bacteroidetes G Carbohydrate kinase, FGGY family protein xylB_2 - 2.7.1.17 ko:K00854 ko00040,ko01100,map00040,map01100 M00014 R01639 RC00002,RC00538 ko00000,ko00001,ko00002,ko01000 - - - FGGY_C,FGGY_N SRD1_k127_2032494_1 326427.Cagg_3745 4.191e-59 210.0 COG0494@1|root,COG0494@2|Bacteria 2|Bacteria L nUDIX hydrolase - - - - - - - - - - - - NUDIX SRD1_k127_2032494_2 153721.MYP_2529 9.244e-05 50.0 COG3652@1|root,COG3652@2|Bacteria,4NQE9@976|Bacteroidetes,47QZE@768503|Cytophagia 976|Bacteroidetes S Domain of unknown function (DUF4142) - - - ko:K08995 - - - - ko00000 - - - DUF4142 SRD1_k127_2038843_1 1173026.Glo7428_4048 6.532e-64 221.0 COG4221@1|root,COG4221@2|Bacteria,1G182@1117|Cyanobacteria 1117|Cyanobacteria S Belongs to the short-chain dehydrogenases reductases (SDR) family - - 1.1.1.276 ko:K05886 - - - - ko00000,ko01000 - - - adh_short SRD1_k127_2038843_0 448385.sce7823 3.286e-91 311.0 COG0812@1|root,COG0812@2|Bacteria,1MXDH@1224|Proteobacteria,42R0K@68525|delta/epsilon subdivisions,2WMTU@28221|Deltaproteobacteria,2Z309@29|Myxococcales 28221|Deltaproteobacteria M Cell wall formation murB - 1.3.1.98 ko:K00075 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R03191,R03192 RC02639 ko00000,ko00001,ko01000,ko01011 - - - FAD_binding_4,MurB_C SRD1_k127_2038843_3 903818.KI912268_gene2872 4.938e-32 132.0 COG1011@1|root,COG1011@2|Bacteria,3Y56D@57723|Acidobacteria 57723|Acidobacteria S HAD-superfamily hydrolase, subfamily IA, variant 3 - - - ko:K07025 - - - - ko00000 - - - HAD_2 SRD1_k127_2038843_2 313612.L8106_26372 1.318e-50 181.0 COG0662@1|root,COG0662@2|Bacteria,1G6DB@1117|Cyanobacteria,1HBDP@1150|Oscillatoriales 1117|Cyanobacteria G Cupin domain - - - - - - - - - - - - Cupin_2 SRD1_k127_2057461_0 1220583.GOACH_01_00430 1.962e-125 410.0 COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria,4GD8Q@85026|Gordoniaceae 201174|Actinobacteria C Aldehyde dehydrogenase family - - - - - - - - - - - - Aldedh SRD1_k127_206259_1 926550.CLDAP_27180 4.182e-108 353.0 COG4284@1|root,COG4284@2|Bacteria 2|Bacteria G Utp--glucose-1-phosphate uridylyltransferase - - 2.7.7.9 ko:K00963 ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130 M00129,M00361,M00362,M00549 R00289 RC00002 ko00000,ko00001,ko00002,ko01000 - - - UDPGP SRD1_k127_206259_0 234267.Acid_1747 1.42e-126 420.0 COG0624@1|root,COG0624@2|Bacteria 2|Bacteria E succinyl-diaminopimelate desuccinylase activity dapE - - - - - - - - - - - M20_dimer,Peptidase_M20,Peptidase_M28,Peptidase_M42 SRD1_k127_206259_2 1121920.AUAU01000011_gene222 1.371e-53 196.0 COG3189@1|root,COG3189@2|Bacteria,3Y86R@57723|Acidobacteria 57723|Acidobacteria S Protein of unknown function, DUF488 - - - - - - - - - - - - DUF488 SRD1_k127_206259_4 744872.Spica_1732 7.68e-18 89.0 2DX1N@1|root,32V2J@2|Bacteria 2|Bacteria S Protein of unknown function (DUF3788) - - - - - - - - - - - - DUF3788 SRD1_k127_206259_3 717605.Theco_1234 7.682e-49 183.0 COG0451@1|root,COG0451@2|Bacteria,1TPHV@1239|Firmicutes,4HCJR@91061|Bacilli,26SNR@186822|Paenibacillaceae 91061|Bacilli GM epimerase - - - - - - - - - - - - Epimerase SRD1_k127_2064474_2 1191523.MROS_0519 7.419e-24 119.0 COG4447@1|root,COG5276@1|root,COG4447@2|Bacteria,COG5276@2|Bacteria 2|Bacteria S cellulose binding - - - - - - - - - - - - Big_5,LVIVD SRD1_k127_2064474_0 56110.Oscil6304_2815 3.757e-69 265.0 COG1404@1|root,COG1520@1|root,COG2931@1|root,COG4733@1|root,COG4935@1|root,COG1404@2|Bacteria,COG1520@2|Bacteria,COG2931@2|Bacteria,COG4733@2|Bacteria,COG4935@2|Bacteria,1G342@1117|Cyanobacteria,1HH6R@1150|Oscillatoriales 1117|Cyanobacteria O Beta-propeller repeat - - - - - - - - - - - - Calx-beta,DUF4114,P_proprotein,Peptidase_S8,SBBP SRD1_k127_2064474_1 1089550.ATTH01000001_gene1148 3.942e-46 193.0 COG1523@1|root,COG4733@1|root,COG1523@2|Bacteria,COG4733@2|Bacteria,4NHA4@976|Bacteroidetes,1FIRB@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes G Belongs to the glycosyl hydrolase 13 family - - - - - - - - - - - - Alpha-amylase,CBM_48,FlgD_ig SRD1_k127_2064474_5 1121930.AQXG01000002_gene2352 1.353e-10 76.0 COG2373@1|root,COG2755@1|root,COG2911@1|root,COG2931@1|root,COG3210@1|root,COG4412@1|root,COG4932@1|root,COG2373@2|Bacteria,COG2755@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG4412@2|Bacteria,COG4932@2|Bacteria 2|Bacteria M domain protein pelX - - ko:K07004,ko:K09955,ko:K16915,ko:K20276 ko02010,ko02024,map02010,map02024 M00246 - - ko00000,ko00001,ko00002,ko02000 - - - Beta_helix,Laminin_G_3 SRD1_k127_2064474_4 1121930.AQXG01000001_gene1460 1.028e-10 76.0 COG2911@1|root,COG3534@1|root,COG4412@1|root,COG2911@2|Bacteria,COG3534@2|Bacteria,COG4412@2|Bacteria,4NXBA@976|Bacteroidetes,1IZ5A@117747|Sphingobacteriia 976|Bacteroidetes Q alpha-L-arabinofuranosidase - - - - - - - - - - - - Invasin_D3 SRD1_k127_2064474_6 1107311.Q767_10900 9.629e-05 57.0 COG3291@1|root,COG3291@2|Bacteria,4PPGY@976|Bacteroidetes,1IBY0@117743|Flavobacteriia,2NX5H@237|Flavobacterium 976|Bacteroidetes U domain, Protein - - - - - - - - - - - - - SRD1_k127_2068907_2 945713.IALB_0746 2.688e-21 100.0 COG1086@1|root,COG1216@1|root,COG2148@1|root,COG1086@2|Bacteria,COG1216@2|Bacteria,COG2148@2|Bacteria 2|Bacteria M undecaprenyl-phosphate glucose phosphotransferase activity wbbL - - ko:K03606,ko:K07011 ko05111,map05111 - - - ko00000,ko00001 - - - Bac_transf,Glyco_tranf_2_3,Glyco_trans_2_3,Glycos_transf_2 SRD1_k127_2068907_0 1191523.MROS_0294 3.442e-150 480.0 COG0825@1|root,COG0825@2|Bacteria 2|Bacteria I malonyl-CoA biosynthetic process accA GO:0001676,GO:0003674,GO:0003824,GO:0003989,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009317,GO:0009329,GO:0009987,GO:0016053,GO:0016421,GO:0016874,GO:0016885,GO:0019752,GO:0032787,GO:0032991,GO:0042759,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576,GO:1902494,GO:1990234 2.1.3.15,6.4.1.2 ko:K01962,ko:K01963 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b0185,iBWG_1329.BWG_0177,iEC55989_1330.EC55989_0179,iECDH10B_1368.ECDH10B_0165,iECDH1ME8569_1439.ECDH1ME8569_0178,iECED1_1282.ECED1_0191,iECH74115_1262.ECH74115_0195,iECIAI1_1343.ECIAI1_0185,iECNA114_1301.ECNA114_0175,iECO111_1330.ECO111_0186,iECO26_1355.ECO26_0187,iECP_1309.ECP_0193,iECSE_1348.ECSE_0184,iECSF_1327.ECSF_0200,iECSP_1301.ECSP_0184,iECW_1372.ECW_m0181,iECs_1301.ECs0187,iEKO11_1354.EKO11_3733,iEcDH1_1363.EcDH1_3418,iEcE24377_1341.EcE24377A_0189,iEcHS_1320.EcHS_A0187,iG2583_1286.G2583_0188,iJN678.accA,iJN746.PP_1607,iJO1366.b0185,iJR904.b0185,iLF82_1304.LF82_0008,iNRG857_1313.NRG857_00945,iSDY_1059.SDY_0201,iSFV_1184.SFV_0168,iSF_1195.SF0175,iSFxv_1172.SFxv_0185,iS_1188.S0178,iUMNK88_1353.UMNK88_190,iWFL_1372.ECW_m0181,iY75_1357.Y75_RS00935,iZ_1308.Z0197 ACCA SRD1_k127_2068907_1 945713.IALB_0748 3.713e-30 122.0 COG0824@1|root,COG0824@2|Bacteria 2|Bacteria IQ Thioesterase - - - ko:K07107 - - - - ko00000,ko01000 - - - 4HBT,4HBT_2 SRD1_k127_208279_1 1047013.AQSP01000134_gene1374 1.664e-16 87.0 COG1277@1|root,COG1277@2|Bacteria 2|Bacteria - - - - - ko:K01992,ko:K16919 ko02010,map02010 M00254,M00584 - - ko00000,ko00001,ko00002,ko02000 3.A.1 - - ABC2_membrane_2,ABC2_membrane_4,ABC_transp_aux SRD1_k127_208279_0 1047013.AQSP01000134_gene1374 2.244e-18 100.0 COG1277@1|root,COG1277@2|Bacteria 2|Bacteria - - - - - ko:K01992,ko:K16919 ko02010,map02010 M00254,M00584 - - ko00000,ko00001,ko00002,ko02000 3.A.1 - - ABC2_membrane_2,ABC2_membrane_4,ABC_transp_aux SRD1_k127_2090920_10 693444.D782_1314 1.633e-08 57.0 COG2259@1|root,COG2259@2|Bacteria,1MZC7@1224|Proteobacteria,1S3U9@1236|Gammaproteobacteria 1236|Gammaproteobacteria S DoxX - - - ko:K15977 - - - - ko00000 - - - DoxX SRD1_k127_2090920_9 68223.JNZY01000044_gene5928 8.038e-10 67.0 COG0723@1|root,COG0723@2|Bacteria,2I2JE@201174|Actinobacteria 201174|Actinobacteria C PFAM Rieske 2Fe-2S - - - - - - - - - - - - Rieske SRD1_k127_2090920_7 1519464.HY22_04505 2.493e-39 155.0 COG2353@1|root,COG2353@2|Bacteria 2|Bacteria O YceI-like domain - - - - - - - - - - - - YceI SRD1_k127_2090920_1 945713.IALB_0986 9.901e-104 353.0 COG1472@1|root,COG1472@2|Bacteria 2|Bacteria G Belongs to the glycosyl hydrolase 3 family nagZ - 3.2.1.52 ko:K01207 ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501 M00628 R00022,R05963,R07809,R07810,R10831 RC00049 ko00000,ko00001,ko00002,ko01000 - - - Glyco_hydro_3 SRD1_k127_2090920_4 861299.J421_0843 2.772e-54 206.0 COG0535@1|root,COG0535@2|Bacteria 2|Bacteria I radical SAM domain protein pqqC - 1.3.3.11 ko:K06137,ko:K06138 - - - - ko00000,ko01000 - - - Fer4_12,Fer4_14,PqqD,Radical_SAM,SPASM,TENA_THI-4 SRD1_k127_2090920_8 479434.Sthe_3410 4.735e-30 128.0 COG0500@1|root,COG2890@1|root,COG2226@2|Bacteria,COG2890@2|Bacteria,2G9F9@200795|Chloroflexi 200795|Chloroflexi Q Methyltransferase domain - - - - - - - - - - - - - SRD1_k127_2090920_6 479434.Sthe_3411 2.723e-40 160.0 COG0500@1|root,COG2226@2|Bacteria 2|Bacteria Q methyltransferase - - 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 - - - MetW,Methyltransf_11,Methyltransf_25,Methyltransf_31 SRD1_k127_2090920_0 714943.Mucpa_3265 2.319e-156 517.0 COG1032@1|root,COG1032@2|Bacteria,4NH8Y@976|Bacteroidetes,1IRE5@117747|Sphingobacteriia 976|Bacteroidetes C B12 binding domain - - - - - - - - - - - - B12-binding,Radical_SAM SRD1_k127_2090920_3 479434.Sthe_3410 3.051e-60 220.0 COG0500@1|root,COG2890@1|root,COG2226@2|Bacteria,COG2890@2|Bacteria,2G9F9@200795|Chloroflexi 200795|Chloroflexi Q Methyltransferase domain - - - - - - - - - - - - - SRD1_k127_2090920_2 1237149.C900_03821 2.692e-60 224.0 COG0438@1|root,COG0438@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups - - - - - - - - - - - - Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1,Glycos_transf_2 SRD1_k127_2090920_5 1237149.C900_03820 6.227e-48 180.0 COG0859@1|root,COG0859@2|Bacteria,4P2TG@976|Bacteroidetes 976|Bacteroidetes M Glycosyltransferase family 9 (heptosyltransferase) - - - - - - - - - - - - Glyco_transf_9 SRD1_k127_2095494_1 1191523.MROS_0092 2.439e-05 47.0 COG0247@1|root,COG1139@1|root,COG0247@2|Bacteria,COG1139@2|Bacteria 2|Bacteria C lactate oxidation lutB - - ko:K00782,ko:K18929 - - - - ko00000 - - - CCG,DUF3390,Fer4_8,LUD_dom SRD1_k127_2095494_0 1047013.AQSP01000108_gene2058 1.86e-189 614.0 COG2091@1|root,COG2091@2|Bacteria,2NQGR@2323|unclassified Bacteria 2|Bacteria H lysine biosynthetic process via aminoadipic acid - - - - - - - - - - - - CBM9_1 SRD1_k127_210116_2 1121935.AQXX01000139_gene2978 9.725e-50 184.0 2BUWD@1|root,32Q8G@2|Bacteria,1RDE8@1224|Proteobacteria,1SQHJ@1236|Gammaproteobacteria,1XPUI@135619|Oceanospirillales 135619|Oceanospirillales S SatD family (SatD) - - - - - - - - - - - - SatD SRD1_k127_210116_3 452637.Oter_2660 1.907e-28 125.0 COG5061@1|root,COG5061@2|Bacteria 2|Bacteria OU protein folding in endoplasmic reticulum satE - - ko:K19134 - - - - ko00000,ko02048 - - - DUF3307 SRD1_k127_210116_1 1379698.RBG1_1C00001G0367 6.022e-96 330.0 COG1253@1|root,COG1253@2|Bacteria,2NP04@2323|unclassified Bacteria 2|Bacteria S Transporter associated domain ytfL GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K03699,ko:K06189 - - - - ko00000,ko02000,ko02042 9.A.40.1.2 - - CBS,CorC_HlyC,DUF21,TerC SRD1_k127_210116_0 1123255.JHYS01000001_gene2116 1.342e-137 449.0 COG0381@1|root,COG0381@2|Bacteria,1MWZN@1224|Proteobacteria,2VJ5C@28216|Betaproteobacteria,4ACCF@80864|Comamonadaceae 28216|Betaproteobacteria G Belongs to the UDP-N-acetylglucosamine 2-epimerase family wecB - 5.1.3.14 ko:K01791 ko00520,ko01100,ko05111,map00520,map01100,map05111 M00362 R00420 RC00290 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Epimerase_2 SRD1_k127_210116_4 1408437.JNJN01000017_gene2258 5.287e-06 59.0 COG0438@1|root,COG0438@2|Bacteria,1TQ1S@1239|Firmicutes,24GPH@186801|Clostridia 186801|Clostridia M glycosyl transferase group 1 - - - - - - - - - - - - Glyco_trans_1_4 SRD1_k127_2104853_0 1089550.ATTH01000001_gene1361 1.827e-112 379.0 COG1501@1|root,COG1501@2|Bacteria,4NE1H@976|Bacteroidetes,1FJTJ@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes G Domain of unknown function (DUF5110) - - 3.2.1.20 ko:K01187 ko00052,ko00500,ko01100,map00052,map00500,map01100 - R00028,R00801,R00802,R06087,R06088 RC00028,RC00049,RC00077 ko00000,ko00001,ko01000 - GH31 - DUF4968,DUF5110,Esterase,Gal_mutarotas_2,Glyco_hydro_31 SRD1_k127_2104853_2 1519464.HY22_13055 5.651e-15 88.0 COG0265@1|root,COG0366@1|root,COG0265@2|Bacteria,COG0366@2|Bacteria 2|Bacteria G hydrolase activity, hydrolyzing O-glycosyl compounds - - 3.4.21.50 ko:K01337 - - - - ko00000,ko01000,ko01002 - - - Alpha-amylase SRD1_k127_2104853_1 1047013.AQSP01000139_gene2321 2.676e-102 342.0 COG1233@1|root,COG1233@2|Bacteria,2NQ26@2323|unclassified Bacteria 2|Bacteria Q Flavin containing amine oxidoreductase - - 1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31,5.2.1.13 ko:K09835,ko:K10027 ko00906,ko01100,ko01110,map00906,map01100,map01110 M00097 R04787,R04798,R04800,R07512,R09691,R09692 RC01214,RC01960,RC02088,RC02605 ko00000,ko00001,ko00002,ko01000 - - - Amino_oxidase SRD1_k127_2109255_0 1211813.CAPH01000004_gene1179 1.259e-51 205.0 COG3250@1|root,COG3250@2|Bacteria 2|Bacteria G beta-galactosidase activity - - - - - - - - - - - - Glyco_hydro_106 SRD1_k127_2117420_6 1191523.MROS_1002 1.941e-24 106.0 COG0445@1|root,COG0445@2|Bacteria 2|Bacteria D tRNA wobble uridine modification gidA GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009451,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 - ko:K03495 - - R08701 RC00053,RC00209,RC00870 ko00000,ko03016,ko03036 - - - GIDA,GIDA_assoc SRD1_k127_2117420_5 1392498.JQLH01000001_gene3082 2.59e-34 141.0 COG0357@1|root,COG0357@2|Bacteria,4NEJG@976|Bacteroidetes,1HYFU@117743|Flavobacteriia,2PG4F@252356|Maribacter 976|Bacteroidetes M rRNA small subunit methyltransferase G rsmG GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.170 ko:K03501 - - - - ko00000,ko01000,ko03009,ko03036 - - - GidB SRD1_k127_2117420_1 518766.Rmar_2753 2.325e-121 396.0 COG2103@1|root,COG2103@2|Bacteria,4NEPY@976|Bacteroidetes,1FIKZ@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes H Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate murQ - 4.2.1.126 ko:K07106 ko00520,ko01100,map00520,map01100 - R08555 RC00397,RC00746 ko00000,ko00001,ko01000 - - - SIS,SIS_2 SRD1_k127_2117420_0 518766.Rmar_2754 1.185e-291 933.0 COG1197@1|root,COG1197@2|Bacteria,4NEPA@976|Bacteroidetes,1FIP1@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF SRD1_k127_2117420_4 945713.IALB_2215 7.397e-45 166.0 COG2001@1|root,COG2001@2|Bacteria 2|Bacteria K Belongs to the MraZ family mraZ GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141 - ko:K03925 - - - - ko00000 - - - MraZ SRD1_k127_2117420_3 1121104.AQXH01000001_gene1869 2.056e-70 250.0 COG0275@1|root,COG0275@2|Bacteria,4NFQB@976|Bacteroidetes,1INNA@117747|Sphingobacteriia 976|Bacteroidetes M Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA rsmH GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.199 ko:K03438 - - - - ko00000,ko01000,ko03009 - - - Methyltransf_5 SRD1_k127_2117420_7 1519464.HY22_00995 6.774e-06 55.0 2FBGK@1|root,343MY@2|Bacteria,1FFFF@1090|Chlorobi 1090|Chlorobi - - - - - - - - - - - - - - - SRD1_k127_2117420_2 517418.Ctha_0827 4.068e-87 304.0 COG0768@1|root,COG2815@1|root,COG0768@2|Bacteria,COG2815@2|Bacteria,1FDDH@1090|Chlorobi 1090|Chlorobi M PFAM penicillin-binding protein transpeptidase - - 3.4.16.4 ko:K03587 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011,ko03036 - - - PASTA,PBP_dimer,Transpeptidase SRD1_k127_2123045_1 290397.Adeh_2789 1.761e-17 85.0 COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,42MEI@68525|delta/epsilon subdivisions,2WJEG@28221|Deltaproteobacteria,2YUPX@29|Myxococcales 28221|Deltaproteobacteria E Asparagine synthase asnB - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 SRD1_k127_2123045_2 1028801.RG1141_CH00960 7.997e-17 82.0 COG0236@1|root,COG0236@2|Bacteria,1NC80@1224|Proteobacteria,2UTZK@28211|Alphaproteobacteria,4BG7C@82115|Rhizobiaceae 28211|Alphaproteobacteria IQ acyl carrier - - - - - - - - - - - - PP-binding SRD1_k127_2123045_0 1411123.JQNH01000001_gene2815 4.057e-139 458.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TRP2@28211|Alphaproteobacteria 28211|Alphaproteobacteria IQ Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C SRD1_k127_2145232_3 1047013.AQSP01000111_gene1687 1.905e-07 63.0 COG1413@1|root,COG1413@2|Bacteria 2|Bacteria C deoxyhypusine monooxygenase activity - - - - - - - - - - - - HEAT_2,HEAT_PBS SRD1_k127_2145232_4 1133850.SHJG_2371 0.0002712 53.0 COG5662@1|root,COG5662@2|Bacteria,2IB76@201174|Actinobacteria 201174|Actinobacteria K Putative zinc-finger - - - - - - - - - - - - zf-HC2 SRD1_k127_2145232_2 1303518.CCALI_02009 1.114e-29 124.0 COG1595@1|root,COG1595@2|Bacteria 2|Bacteria K DNA-templated transcription, initiation - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 SRD1_k127_2145232_1 706434.HMPREF9429_01046 4.203e-34 147.0 COG1538@1|root,COG1538@2|Bacteria,1TRDS@1239|Firmicutes,4H2S7@909932|Negativicutes 909932|Negativicutes MU outer membrane efflux protein tolC - - - - - - - - - - - OEP SRD1_k127_2145232_0 330214.NIDE0726 1.049e-218 702.0 COG0841@1|root,COG0841@2|Bacteria,3J0ZG@40117|Nitrospirae 40117|Nitrospirae V AcrB/AcrD/AcrF family - - - - - - - - - - - - ACR_tran SRD1_k127_2156027_2 1121100.JCM6294_3003 5.628e-31 128.0 COG1595@1|root,COG1595@2|Bacteria,4NQW2@976|Bacteroidetes,2FREW@200643|Bacteroidia,4APP7@815|Bacteroidaceae 976|Bacteroidetes K Sigma-70, region 4 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 SRD1_k127_2156027_3 742727.HMPREF9447_02467 2.375e-10 72.0 2D9Y9@1|root,32TU8@2|Bacteria,4NT8A@976|Bacteroidetes,2FPKI@200643|Bacteroidia,4ANHD@815|Bacteroidaceae 976|Bacteroidetes - - - - - - - - - - - - - - - SRD1_k127_2156027_0 665959.HMPREF1013_01239 1.747e-135 448.0 COG1129@1|root,COG1129@2|Bacteria,1TP6I@1239|Firmicutes,4H9VK@91061|Bacilli,1ZB07@1386|Bacillus 91061|Bacilli G Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system rbsA GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0006810,GO:0008144,GO:0008150,GO:0008643,GO:0015144,GO:0015145,GO:0015146,GO:0015399,GO:0015405,GO:0015407,GO:0015591,GO:0015608,GO:0015611,GO:0015749,GO:0015750,GO:0015752,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034219,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0043167,GO:0043168,GO:0043211,GO:0043492,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0097159,GO:0097367,GO:1901265,GO:1901363 3.6.3.17 ko:K10441 ko02010,map02010 M00212 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 - - ABC_tran SRD1_k127_2156027_1 411684.HPDFL43_01955 8.994e-70 257.0 COG1172@1|root,COG1172@2|Bacteria,1MX7D@1224|Proteobacteria,2TV15@28211|Alphaproteobacteria,43QWW@69277|Phyllobacteriaceae 28211|Alphaproteobacteria U Belongs to the binding-protein-dependent transport system permease family - - - ko:K10440 ko02010,map02010 M00212 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 - - BPD_transp_2 SRD1_k127_215657_3 1121931.AUHG01000011_gene2154 6.685e-29 119.0 COG2070@1|root,COG2070@2|Bacteria,4NF8Z@976|Bacteroidetes,1HYHD@117743|Flavobacteriia 976|Bacteroidetes S 2-nitropropane dioxygenase fabK - 1.3.1.9 ko:K02371 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00083 R04429,R04724,R04955,R04958,R04961,R04966,R04969,R07765 RC00052,RC00076 ko00000,ko00001,ko00002,ko01000,ko01004 - - - NMO SRD1_k127_215657_0 1183438.GKIL_0991 1.956e-232 733.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1G0PS@1117|Cyanobacteria 1117|Cyanobacteria H Methionine synthase metH GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019752,GO:0032259,GO:0042084,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans SRD1_k127_215657_1 66874.JOFS01000030_gene8042 1.138e-185 597.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,2GM5Q@201174|Actinobacteria 201174|Actinobacteria E Methionine synthase metH GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016741,GO:0019752,GO:0030312,GO:0032259,GO:0042084,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans SRD1_k127_215657_2 497964.CfE428DRAFT_1183 1.318e-87 298.0 COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria 2|Bacteria C FAD linked oxidase domain protein - - - ko:K06911 - - - - ko00000 - - - CCG,FAD-oxidase_C,FAD_binding_4,Fer4_8 SRD1_k127_2157384_0 1191523.MROS_0284 1.432e-92 316.0 COG2067@1|root,COG2067@2|Bacteria 2|Bacteria I long-chain fatty acid transporting porin activity - - - - - - - - - - - - PorP_SprF SRD1_k127_2157384_1 1191523.MROS_0285 6.909e-52 186.0 2E09V@1|root,32VXB@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - SRD1_k127_2157545_6 1459636.NTE_01731 2.068e-15 82.0 arCOG00567@1|root,arCOG00567@2157|Archaea 2157|Archaea S glycosyl transferase family - - 2.4.99.18 ko:K07151 ko00510,ko00513,ko01100,ko04141,map00510,map00513,map01100,map04141 M00072 R04216,R05976 RC00005,RC00482 ko00000,ko00001,ko00002,ko01000,ko01003 - GT66 - PMT_2 SRD1_k127_2157545_5 1379270.AUXF01000002_gene1400 3.976e-22 107.0 29X7E@1|root,30IWN@2|Bacteria,1ZV4U@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Domain of unknown function (DUF4397) - - - - - - - - - - - - DUF4397 SRD1_k127_2157545_4 1267533.KB906747_gene24 3.033e-37 145.0 COG0838@1|root,COG0838@2|Bacteria 2|Bacteria C NADH dehydrogenase (ubiquinone) activity nuoA GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0050136,GO:0055114,GO:0098796,GO:1902494 1.6.5.3 ko:K00330 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q4 SRD1_k127_2157545_2 105559.Nwat_1902 5.327e-97 324.0 COG0377@1|root,COG0377@2|Bacteria,1MUI2@1224|Proteobacteria,1RP4R@1236|Gammaproteobacteria,1WW6I@135613|Chromatiales 135613|Chromatiales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient - - 1.6.5.3 ko:K00331 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q6 SRD1_k127_2157545_0 1123368.AUIS01000006_gene657 1.75e-284 884.0 COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,1RM98@1236|Gammaproteobacteria,2NBZB@225057|Acidithiobacillales 225057|Acidithiobacillales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient - - 1.6.5.3 ko:K13378 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_30kDa,Complex1_49kDa SRD1_k127_2157545_3 880073.Calab_1090 7.555e-57 203.0 COG1905@1|root,COG1905@2|Bacteria,2NR6Q@2323|unclassified Bacteria 2|Bacteria C NADH ubiquinone oxidoreductase 24 kD subunit nuoE GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008137,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0048037,GO:0050136,GO:0051536,GO:0051537,GO:0051540,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204 1.6.5.3 ko:K00334 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - iYL1228.KPN_02675 2Fe-2S_thioredx SRD1_k127_2157545_1 1123248.KB893322_gene648 1.971e-137 441.0 COG1894@1|root,COG1894@2|Bacteria,4NHD2@976|Bacteroidetes,1IVX2@117747|Sphingobacteriia 976|Bacteroidetes C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain - - 1.6.5.3 ko:K00335 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_51K,NADH_4Fe-4S,SLBB SRD1_k127_2159969_3 1235794.C811_01670 0.0002799 46.0 COG2239@1|root,COG2239@2|Bacteria,2GMMK@201174|Actinobacteria,4CUUS@84998|Coriobacteriia 84998|Coriobacteriia P Magnesium transporter - - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE_N,PRC SRD1_k127_2159969_2 404589.Anae109_3838 2.927e-56 214.0 COG1409@1|root,COG1409@2|Bacteria,1NS3S@1224|Proteobacteria,43AFC@68525|delta/epsilon subdivisions,2X64J@28221|Deltaproteobacteria,2Z0UN@29|Myxococcales 28221|Deltaproteobacteria G Purple acid Phosphatase, N-terminal domain - - - - - - - - - - - - Metallophos,Pur_ac_phosph_N SRD1_k127_2159969_1 518766.Rmar_1038 2.31e-80 277.0 COG3118@1|root,COG3118@2|Bacteria,4NR34@976|Bacteroidetes,1FJ8D@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes O Thioredoxin-like domain - - - ko:K05838 - - - - ko00000,ko03110 - - - TPR_20,Thioredoxin SRD1_k127_2159969_0 246194.CHY_2199 5.493e-112 373.0 COG1104@1|root,COG1104@2|Bacteria,1TP21@1239|Firmicutes,24888@186801|Clostridia,42FGX@68295|Thermoanaerobacterales 186801|Clostridia H Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins iscS - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 SRD1_k127_2170684_6 1191523.MROS_1378 4.537e-17 81.0 COG0499@1|root,COG0499@2|Bacteria 2|Bacteria H adenosylhomocysteinase activity ahcY - 3.3.1.1 ko:K01251 ko00270,ko01100,map00270,map01100 M00035 R00192,R04936 RC00056,RC00069,RC01161,RC01243 ko00000,ko00001,ko00002,ko01000,ko01009,ko04147 - - - AdoHcyase,AdoHcyase_NAD SRD1_k127_2170684_0 1191523.MROS_1377 9.825e-183 577.0 COG0192@1|root,COG0192@2|Bacteria 2|Bacteria H methionine adenosyltransferase activity metK GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - - S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N SRD1_k127_2170684_2 1519464.HY22_02585 1.248e-124 409.0 COG1209@1|root,COG1209@2|Bacteria,1FD8Z@1090|Chlorobi 1090|Chlorobi M Nucleotidyl transferase - - 2.7.7.24 ko:K00973 ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130 M00793 R02328 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transferase SRD1_k127_2170684_3 324925.Ppha_0414 9.946e-92 318.0 COG1304@1|root,COG1304@2|Bacteria,1FDB6@1090|Chlorobi 1090|Chlorobi F Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) fni - 5.3.3.2 ko:K01823 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00095,M00096,M00364,M00365,M00366,M00367 R01123 RC00455 ko00000,ko00001,ko00002,ko01000 - - - FMN_dh SRD1_k127_2170684_4 1191523.MROS_2581 5.602e-77 271.0 COG0142@1|root,COG0142@2|Bacteria 2|Bacteria H isoprenoid biosynthetic process idsA - 2.5.1.1,2.5.1.10,2.5.1.29 ko:K13787,ko:K13789 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00364,M00365,M00366 R01658,R02003,R02061 RC00279 ko00000,ko00001,ko00002,ko01000,ko01006 - - - polyprenyl_synt SRD1_k127_2170684_5 309807.SRU_1873 1.46e-29 119.0 COG1925@1|root,COG1925@2|Bacteria,4NZ3F@976|Bacteroidetes,1FJGF@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes G PTS HPr component phosphorylation site - - - ko:K11189 - - - - ko00000,ko02000 4.A.2.1 - - PTS-HPr SRD1_k127_2170684_1 1191523.MROS_2579 4.446e-158 518.0 COG1080@1|root,COG1080@2|Bacteria 2|Bacteria G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) ptsI - 2.7.3.9 ko:K08483 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 8.A.7 - - PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C SRD1_k127_2180079_1 706587.Desti_4167 1.941e-148 477.0 COG0659@1|root,COG0659@2|Bacteria,1MXA7@1224|Proteobacteria,42ZHY@68525|delta/epsilon subdivisions,2WV08@28221|Deltaproteobacteria 28221|Deltaproteobacteria P secondary active sulfate transmembrane transporter activity - - - ko:K06901 - - - - ko00000,ko02000 2.A.1.40 - - - SRD1_k127_2180079_0 1191523.MROS_2462 1.084e-148 482.0 COG1972@1|root,COG1972@2|Bacteria 2|Bacteria F Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family yeiM - - ko:K03317 - - - - ko00000 2.A.41 - - Gate,Nucleos_tra2_C,Nucleos_tra2_N SRD1_k127_2183258_2 1121930.AQXG01000005_gene601 2.581e-16 79.0 COG1404@1|root,COG1404@2|Bacteria,4NVH2@976|Bacteroidetes,1IURU@117747|Sphingobacteriia 976|Bacteroidetes O Belongs to the peptidase S8 family - - - - - - - - - - - - - SRD1_k127_2183258_1 1237149.C900_02500 1.71e-73 266.0 COG2085@1|root,COG2085@2|Bacteria,4NQ1G@976|Bacteroidetes,47Q30@768503|Cytophagia 976|Bacteroidetes S NADP oxidoreductase coenzyme F420-dependent - - 1.5.1.40 ko:K06988 - - - - ko00000,ko01000 - - - F420_oxidored SRD1_k127_2183258_0 945713.IALB_2314 1.48e-77 286.0 COG4447@1|root,COG4447@2|Bacteria 2|Bacteria S cellulose binding - - - - - - - - - - - - PSII_BNR SRD1_k127_2184294_0 1191523.MROS_0727 7.865e-290 925.0 COG0436@1|root,COG0436@2|Bacteria 2|Bacteria E Aminotransferase - - - ko:K21572 - - - - ko00000,ko02000 8.A.46.1,8.A.46.3 - - SusD-like_3,SusD_RagB SRD1_k127_2185675_0 1173028.ANKO01000151_gene5291 1.673e-46 181.0 COG0671@1|root,COG2931@1|root,COG0671@2|Bacteria,COG2931@2|Bacteria,1G3V2@1117|Cyanobacteria,1H9MJ@1150|Oscillatoriales 1117|Cyanobacteria Q Hemolysin-type calcium-binding repeat (2 copies) - - - - - - - - - - - - HemolysinCabind,PAP2 SRD1_k127_2185675_1 1205753.A989_09476 9.285e-13 72.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1X59D@135614|Xanthomonadales 135614|Xanthomonadales T Sigma-54 interaction domain - - - ko:K02481 - - - - ko00000,ko02022 - - - HTH_8,Response_reg,Sigma54_activat SRD1_k127_2187399_5 234267.Acid_4378 1.143e-29 120.0 COG2322@1|root,COG2322@2|Bacteria,3Y5H4@57723|Acidobacteria 57723|Acidobacteria S Protein of unknown function (DUF420) - - - ko:K08976 - - - - ko00000 - - - DUF420 SRD1_k127_2187399_2 1345023.M467_06880 4.817e-69 244.0 COG0005@1|root,COG0005@2|Bacteria,1TQ37@1239|Firmicutes,4HABP@91061|Bacilli,3WE6V@539002|Bacillales incertae sedis 91061|Bacilli F The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate punA - 2.4.2.1,2.4.2.28 ko:K00772,ko:K03783 ko00230,ko00240,ko00270,ko00760,ko01100,ko01110,map00230,map00240,map00270,map00760,map01100,map01110 M00034 R01402,R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244 RC00033,RC00063,RC00122,RC02819 ko00000,ko00001,ko00002,ko01000 - - - PNP_UDP_1 SRD1_k127_2187399_1 1191523.MROS_2463 7.471e-76 266.0 COG1435@1|root,COG1435@2|Bacteria 2|Bacteria F thymidine kinase activity tdk GO:0003674,GO:0003824,GO:0004797,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006259,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009120,GO:0009123,GO:0009124,GO:0009157,GO:0009162,GO:0009165,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0018130,GO:0019136,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046104,GO:0046125,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0090304,GO:0090407,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657 2.7.1.21 ko:K00857 ko00240,ko00983,ko01100,map00240,map00983,map01100 - R01567,R02099,R08233 RC00002,RC00017 ko00000,ko00001,ko01000 - - iLJ478.TM0401 TK SRD1_k127_2187399_3 1242864.D187_008666 1.463e-40 168.0 COG1408@1|root,COG1408@2|Bacteria,1MUH5@1224|Proteobacteria,42Q51@68525|delta/epsilon subdivisions,2WIMQ@28221|Deltaproteobacteria,2YYKM@29|Myxococcales 28221|Deltaproteobacteria S Calcineurin-like phosphoesterase - - - ko:K07098 - - - - ko00000 - - - CarS-like,Metallophos SRD1_k127_2187399_4 1191523.MROS_2500 1.639e-32 137.0 COG2815@1|root,COG2815@2|Bacteria 2|Bacteria G serine threonine protein kinase spk1 - 2.7.11.1,3.4.16.4,6.3.2.4 ko:K01921,ko:K03587,ko:K08884,ko:K12132 ko00473,ko00550,ko01100,ko01501,ko01502,map00473,map00550,map01100,map01501,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01001,ko01011,ko03036 - - - PASTA,TIR_2 SRD1_k127_2187399_0 1430331.EP10_16745 4.359e-80 272.0 COG0036@1|root,COG0036@2|Bacteria,1TQK8@1239|Firmicutes,4H9RW@91061|Bacilli,1WE4J@129337|Geobacillus 91061|Bacilli G Ribulose-phosphate 3 epimerase family rpe GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046496,GO:0046872,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575 5.1.3.1 ko:K01783 ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01529 RC00540 ko00000,ko00001,ko00002,ko01000 - - - Ribul_P_3_epim SRD1_k127_2187399_6 1232437.KL662020_gene724 8.587e-12 68.0 COG1971@1|root,COG1971@2|Bacteria,1NWBY@1224|Proteobacteria,42RE2@68525|delta/epsilon subdivisions,2WNEN@28221|Deltaproteobacteria,2MK2I@213118|Desulfobacterales 28221|Deltaproteobacteria P Probably functions as a manganese efflux pump mntP - - - - - - - - - - - Mntp SRD1_k127_2188987_4 240292.Ava_3338 9.583e-48 173.0 COG1028@1|root,COG1028@2|Bacteria,1G2FK@1117|Cyanobacteria,1HMHE@1161|Nostocales 1117|Cyanobacteria IQ Enoyl-(Acyl carrier protein) reductase - - 1.1.1.206 ko:K08081 ko00960,ko01100,ko01110,map00960,map01100,map01110 - R02832 RC00144 ko00000,ko00001,ko01000 - - - adh_short_C2 SRD1_k127_2188987_1 452637.Oter_0864 1.382e-178 571.0 COG2211@1|root,COG2211@2|Bacteria,46UJY@74201|Verrucomicrobia 74201|Verrucomicrobia G MFS/sugar transport protein - - - - - - - - - - - - MFS_1 SRD1_k127_2188987_2 1535422.ND16A_2634 8.449e-142 462.0 COG2211@1|root,COG2211@2|Bacteria 2|Bacteria G Major facilitator Superfamily - - - - - - - - - - - - MFS_1 SRD1_k127_2188987_0 1519464.HY22_09460 1.744e-200 644.0 COG0366@1|root,COG0366@2|Bacteria,1FD8X@1090|Chlorobi 1090|Chlorobi G PFAM alpha amylase, catalytic region - - - - - - - - - - - - Alpha-amylase,hDGE_amylase SRD1_k127_2188987_3 1519464.HY22_13055 3.083e-66 236.0 COG0265@1|root,COG0366@1|root,COG0265@2|Bacteria,COG0366@2|Bacteria 2|Bacteria G hydrolase activity, hydrolyzing O-glycosyl compounds - - 3.4.21.50 ko:K01337 - - - - ko00000,ko01000,ko01002 - - - Alpha-amylase SRD1_k127_2197616_1 2423.NA23_0205420 5.244e-99 331.0 COG1012@1|root,COG1012@2|Bacteria,2GCJA@200918|Thermotogae 200918|Thermotogae C PFAM Aldehyde dehydrogenase - - 1.2.1.88 ko:K00294 ko00250,ko00330,ko01100,map00250,map00330,map01100 - R00245,R00707,R00708,R04444,R04445,R05051 RC00080,RC00216,RC00242,RC00255 ko00000,ko00001,ko01000 - - - Aldedh SRD1_k127_2197616_2 1499967.BAYZ01000171_gene5559 3.54e-98 329.0 COG0190@1|root,COG0190@2|Bacteria,2NNY1@2323|unclassified Bacteria 2|Bacteria E Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate folD GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114 1.5.1.5,3.5.4.9 ko:K01491 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R01220,R01655 RC00202,RC00578 ko00000,ko00001,ko00002,ko01000 - - - THF_DHG_CYH,THF_DHG_CYH_C SRD1_k127_2197616_3 1121104.AQXH01000001_gene989 2.605e-85 290.0 COG1692@1|root,COG1692@2|Bacteria 2|Bacteria S 2',3'-cyclic-nucleotide 2'-phosphodiesterase activity ymdB GO:0003674,GO:0003824,GO:0004112,GO:0004113,GO:0008081,GO:0016787,GO:0016788,GO:0042578 - ko:K02029,ko:K02030,ko:K09769 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - YmdB SRD1_k127_2197616_0 1196322.A370_03398 2.328e-129 423.0 COG0821@1|root,COG0821@2|Bacteria,1TPFR@1239|Firmicutes,247N1@186801|Clostridia,36DRW@31979|Clostridiaceae 186801|Clostridia I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate ispG - 1.17.7.1,1.17.7.3 ko:K03526 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R08689,R10859 RC01486 ko00000,ko00001,ko00002,ko01000 - - - GcpE SRD1_k127_2197616_4 1191523.MROS_1922 3.361e-78 271.0 COG0705@1|root,COG0705@2|Bacteria 2|Bacteria S proteolysis - - - - - - - - - - - - Rhomboid SRD1_k127_2197616_5 880073.Calab_3780 7.486e-78 264.0 COG0126@1|root,COG0126@2|Bacteria,2NNN1@2323|unclassified Bacteria 2|Bacteria G Belongs to the phosphoglycerate kinase family pgk GO:0003674,GO:0003824,GO:0004618,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 2.7.2.3,5.3.1.1 ko:K00927,ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01015,R01512 RC00002,RC00043,RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGK SRD1_k127_2206188_1 891968.Anamo_1584 3.423e-64 229.0 COG0438@1|root,COG0438@2|Bacteria,3TAFG@508458|Synergistetes 508458|Synergistetes H PFAM glycosyl transferase group 1 - - 2.4.1.245 ko:K13057 ko00500,ko01100,map00500,map01100 - R08946,R10525,R11306 RC00005,RC00049,RC02748 ko00000,ko00001,ko01000 - GT4 - Glycos_transf_1 SRD1_k127_2206188_2 891968.Anamo_1585 1.679e-54 198.0 COG0438@1|root,COG0438@2|Bacteria,3TC5G@508458|Synergistetes 508458|Synergistetes M transferase activity, transferring glycosyl groups - - - - - - - - - - - - - SRD1_k127_2206188_0 861299.J421_5672 2.104e-226 707.0 COG2334@1|root,COG2334@2|Bacteria 2|Bacteria S homoserine kinase activity - - 2.7.1.39 ko:K02204 ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230 M00018 R01771 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - APH,Glyco_hydro_63 SRD1_k127_221323_5 522306.CAP2UW1_0855 0.0007466 49.0 COG0438@1|root,COG0438@2|Bacteria,1N8I7@1224|Proteobacteria,2VWX7@28216|Betaproteobacteria 28216|Betaproteobacteria M Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_trans_1_4,Glycos_transf_1 SRD1_k127_221323_2 1123054.KB907702_gene1608 4.926e-127 422.0 COG0677@1|root,COG0677@2|Bacteria,1MUC6@1224|Proteobacteria,1RMX0@1236|Gammaproteobacteria,1WWWS@135613|Chromatiales 135613|Chromatiales M PFAM UDP-glucose GDP-mannose dehydrogenase family, NAD binding domain - - 1.1.1.336 ko:K02472 ko00520,ko05111,map00520,map05111 - R03317 RC00291 ko00000,ko00001,ko01000 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N SRD1_k127_221323_3 517418.Ctha_0363 1.577e-87 302.0 COG1817@1|root,COG1817@2|Bacteria,1FF3N@1090|Chlorobi 1090|Chlorobi S Protein of unknown function (DUF354) - - - ko:K09726 - - - - ko00000 - - - DUF354 SRD1_k127_221323_1 1519464.HY22_05655 8.995e-128 420.0 COG1331@1|root,COG1331@2|Bacteria,1FEHU@1090|Chlorobi 1090|Chlorobi O Highly conserved protein containing a thioredoxin domain - - - - - - - - - - - - - SRD1_k127_221323_0 204669.Acid345_3794 1.567e-254 805.0 COG0673@1|root,COG1063@1|root,COG0673@2|Bacteria,COG1063@2|Bacteria,3Y3WP@57723|Acidobacteria,2JMAR@204432|Acidobacteriia 204432|Acidobacteriia E Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - ADH_zinc_N,GFO_IDH_MocA SRD1_k127_221323_4 1121033.AUCF01000004_gene5092 1.185e-18 97.0 COG0438@1|root,COG0438@2|Bacteria,1MVKK@1224|Proteobacteria,2U963@28211|Alphaproteobacteria,2JTTD@204441|Rhodospirillales 204441|Rhodospirillales M Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_trans_4_4,Glycos_transf_1 SRD1_k127_221693_3 880073.Calab_3627 9.66e-24 104.0 COG2374@1|root,COG2911@1|root,COG3386@1|root,COG2374@2|Bacteria,COG2911@2|Bacteria,COG3386@2|Bacteria 2|Bacteria G gluconolactonase activity gnl GO:0003674,GO:0003824,GO:0004341,GO:0016787,GO:0016788,GO:0052689 1.15.1.1,2.7.11.1,3.1.1.17,3.1.1.2,3.1.3.8,3.1.8.1,3.2.1.4,4.3.3.2 ko:K01045,ko:K01053,ko:K01083,ko:K01179,ko:K01757,ko:K02057,ko:K04565,ko:K08884,ko:K13735 ko00030,ko00053,ko00500,ko00562,ko00901,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko04146,ko04213,ko05014,ko05016,ko05020,ko05100,map00030,map00053,map00500,map00562,map00901,map00930,map01100,map01110,map01120,map01130,map01200,map01220,map04146,map04213,map05014,map05016,map05020,map05100 M00129,M00221 R01519,R02933,R03371,R03738,R03751,R06200,R11307,R11308 RC00078,RC00537,RC00983,RC01072,RC01568 ko00000,ko00001,ko00002,ko01000,ko01001,ko02000,ko04147 3.A.1.2 GH5,GH9 - SGL,Str_synth SRD1_k127_221693_1 386456.JQKN01000007_gene3251 1.014e-158 512.0 arCOG02685@1|root,arCOG02685@2157|Archaea,2XV10@28890|Euryarchaeota 28890|Euryarchaeota G COG0477 Permeases of the major facilitator superfamily csbC - - - - - - - - - - - Sugar_tr SRD1_k127_221693_2 945713.IALB_0222 3.455e-65 239.0 COG2382@1|root,COG2382@2|Bacteria 2|Bacteria P enterobactin catabolic process yjcH - - ko:K07214 - - - - ko00000 - - - Esterase SRD1_k127_221693_0 1304874.JAFY01000005_gene1625 2.91e-173 552.0 COG0520@1|root,COG0520@2|Bacteria,3TAAX@508458|Synergistetes 508458|Synergistetes E TIGRFAM cysteine desulfurase family protein, VC1184 subfamily - - - - - - - - - - - - Aminotran_5 SRD1_k127_2217779_1 316274.Haur_4441 6.488e-99 326.0 COG0065@1|root,COG0065@2|Bacteria,2G68G@200795|Chloroflexi,3753P@32061|Chloroflexia 32061|Chloroflexia H Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate - - 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase SRD1_k127_2217779_2 926569.ANT_03320 3.939e-74 255.0 COG0066@1|root,COG0066@2|Bacteria,2G6JE@200795|Chloroflexi 200795|Chloroflexi E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate - - 4.2.1.33,4.2.1.35 ko:K01704 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R10170 RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase_C SRD1_k127_2217779_0 290397.Adeh_2071 6.734e-116 378.0 COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,42MAV@68525|delta/epsilon subdivisions,2WJC9@28221|Deltaproteobacteria,2YW7U@29|Myxococcales 28221|Deltaproteobacteria H Belongs to the alpha-IPM synthase homocitrate synthase family cimA - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer SRD1_k127_2225179_2 1047013.AQSP01000142_gene205 1.104e-72 251.0 COG3408@1|root,COG3408@2|Bacteria 2|Bacteria G Glycogen debranching enzyme - - - - - - - - - - - - Bac_rhamnosid6H,Bac_rhamnosid_C,Big_4,CBM_6,Crystall,Glyco_hydro_64,RicinB_lectin_2,SLH,Trehalase SRD1_k127_2225179_0 1047013.AQSP01000126_gene2729 8.039e-142 478.0 28MYJ@1|root,2ZB5F@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - SRD1_k127_2225179_1 1123024.AUII01000038_gene4086 1.015e-77 273.0 COG0620@1|root,COG0620@2|Bacteria,2GIXA@201174|Actinobacteria,4DX7E@85010|Pseudonocardiales 201174|Actinobacteria E Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation metE - 2.1.1.14 ko:K00549 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 M00017 R04405,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - Meth_synt_1,Meth_synt_2 SRD1_k127_2225179_3 945713.IALB_1001 3.062e-27 123.0 COG2067@1|root,COG2067@2|Bacteria 2|Bacteria I long-chain fatty acid transporting porin activity - - - - - - - - - - - - - SRD1_k127_2229786_1 573.JG24_07565 3.242e-46 182.0 COG1080@1|root,COG1762@1|root,COG1925@1|root,COG1080@2|Bacteria,COG1762@2|Bacteria,COG1925@2|Bacteria,1MUT8@1224|Proteobacteria,1RN6R@1236|Gammaproteobacteria 1236|Gammaproteobacteria G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) ptsA - 2.7.3.9 ko:K08483,ko:K11189,ko:K11201 ko02060,map02060 M00306 - - ko00000,ko00001,ko00002,ko01000,ko02000 4.A.2.1,8.A.7 - - PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C,PTS-HPr,PTS_EIIA_2 SRD1_k127_2229786_2 1283284.AZUK01000001_gene1960 5.441e-33 135.0 COG1445@1|root,COG1445@2|Bacteria,1N1D8@1224|Proteobacteria,1SFDU@1236|Gammaproteobacteria,1Y6ED@135624|Aeromonadales 135624|Aeromonadales G PTS system, Lactose/Cellobiose specific IIB subunit - - 2.7.1.202 ko:K02769 ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060 M00273 R03232 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.2.1 - - PTS_IIB SRD1_k127_2229786_0 243365.CV_2309 1.134e-52 188.0 COG1299@1|root,COG1299@2|Bacteria,1MXFN@1224|Proteobacteria,2VK5D@28216|Betaproteobacteria,2KSKJ@206351|Neisseriales 2|Bacteria G PTS system, fructose subfamily, IIC subunit fruA-1 - 2.7.1.202 ko:K02768,ko:K02769,ko:K02770,ko:K11203 ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060 M00273,M00306 R03232 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.2.1 - - PTS_EIIA_2,PTS_EIIC,PTS_IIB SRD1_k127_2230653_1 443144.GM21_3966 5.347e-103 354.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria 1224|Proteobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,PAS_4,Response_reg SRD1_k127_2230653_2 518766.Rmar_1198 1.557e-86 298.0 COG0276@1|root,COG0276@2|Bacteria,4NE83@976|Bacteroidetes,1FJ5M@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes H Catalyzes the ferrous insertion into protoporphyrin IX hemH - 4.99.1.1,4.99.1.9 ko:K01772 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R00310,R11329 RC01012 ko00000,ko00001,ko00002,ko01000 - - - Ferrochelatase SRD1_k127_2230653_0 880073.Calab_3717 3.48e-126 419.0 COG1232@1|root,COG1232@2|Bacteria,2NQ1W@2323|unclassified Bacteria 2|Bacteria H Flavin containing amine oxidoreductase hemG - 1.14.19.9,1.3.3.15,1.3.3.4 ko:K00231,ko:K14266 ko00404,ko00860,ko01100,ko01110,ko01130,map00404,map00860,map01100,map01110,map01130 M00121,M00789,M00790 R03222,R04178,R09570 RC00885,RC00949 ko00000,ko00001,ko00002,ko01000 - - iSB619.SA_RS09325 Amino_oxidase SRD1_k127_2231179_0 1459636.NTE_00007 1.073e-66 246.0 COG0417@1|root,arCOG00329@2157|Archaea 2157|Archaea L DNA polymerase elongation subunit (Family B) polB2 - 2.7.7.7 ko:K02319 ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032 - - - DNA_pol_B SRD1_k127_2231179_1 1123278.KB893389_gene4211 6.993e-12 78.0 COG1598@1|root,COG1598@2|Bacteria 2|Bacteria N PFAM Uncharacterised protein family UPF0150 - - - - - - - - - - - - HicB_lk_antitox SRD1_k127_2241068_0 1267535.KB906767_gene4376 1.681e-70 246.0 COG0367@1|root,COG0367@2|Bacteria 2|Bacteria E asparagine synthase - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 SRD1_k127_2241068_2 309799.DICTH_0438 1.546e-50 196.0 COG0438@1|root,COG0438@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups wblG - - - - - - - - - - - Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 SRD1_k127_2241068_1 504728.K649_01450 7.629e-62 222.0 COG0726@1|root,COG0726@2|Bacteria 2|Bacteria G polysaccharide deacetylase - - 3.5.1.104 ko:K22278 - - - - ko00000,ko01000 - - - Polysacc_deac_1 SRD1_k127_2241068_3 1122180.Lokhon_02139 8.471e-18 93.0 COG0438@1|root,COG0438@2|Bacteria,1MVKK@1224|Proteobacteria,2TUFG@28211|Alphaproteobacteria,2P999@245186|Loktanella 28211|Alphaproteobacteria M Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1 SRD1_k127_2241950_0 1463936.JOJI01000016_gene134 2.295e-81 280.0 COG1129@1|root,COG1129@2|Bacteria,2GJ3F@201174|Actinobacteria 201174|Actinobacteria G Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system rbsA - 3.6.3.17 ko:K10441 ko02010,map02010 M00212 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 - - ABC_tran SRD1_k127_2241950_1 1382358.JHVN01000004_gene2648 4.826e-72 261.0 COG4214@1|root,COG4214@2|Bacteria,1VU1F@1239|Firmicutes,4HBDM@91061|Bacilli,21VZU@150247|Anoxybacillus 91061|Bacilli G Branched-chain amino acid transport system / permease component - - - ko:K10544 ko02010,map02010 M00215 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2.4 - - BPD_transp_2 SRD1_k127_2241950_2 1089550.ATTH01000001_gene389 1.473e-65 232.0 COG0639@1|root,COG0639@2|Bacteria,4NFPU@976|Bacteroidetes 976|Bacteroidetes T Diadenosine tetraphosphatase and related serine threonine protein - - - - - - - - - - - - Metallophos_2 SRD1_k127_2252948_4 1288083.AUKR01000014_gene3010 4.611e-05 49.0 COG0300@1|root,COG0300@2|Bacteria,2I5J6@201174|Actinobacteria 201174|Actinobacteria S KR domain - GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0016999,GO:0017000,GO:0017144,GO:0018130,GO:0044237,GO:0044249,GO:0046483,GO:0055114,GO:0071704,GO:1901334,GO:1901336,GO:1901360,GO:1901362,GO:1901576 1.1.1.340 ko:K17747 ko01130,map01130 M00819 - - ko00000,ko00001,ko00002,ko01000 - - - adh_short SRD1_k127_2252948_1 290512.Paes_2166 2.679e-105 364.0 2CCJ8@1|root,335J6@2|Bacteria,1FES4@1090|Chlorobi 1090|Chlorobi - - - - - - - - - - - - - - - SRD1_k127_2252948_3 945713.IALB_2304 5.166e-46 177.0 2CBKC@1|root,32RTJ@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - SRD1_k127_2252948_0 459349.CLOAM0997 3.185e-139 457.0 COG0008@1|root,COG0008@2|Bacteria,2NNMZ@2323|unclassified Bacteria 2|Bacteria J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) gltX - 6.1.1.17,6.1.1.24 ko:K01885,ko:K09698 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R03651,R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 - - - tRNA-synt_1c SRD1_k127_2252948_2 1121472.AQWN01000008_gene1930 1.257e-58 208.0 COG0008@1|root,COG0008@2|Bacteria,1TP8G@1239|Firmicutes,247Y0@186801|Clostridia,2607A@186807|Peptococcaceae 186801|Clostridia J PFAM tRNA synthetases class I (E and Q), catalytic domain glnS - 6.1.1.18 ko:K01886 ko00970,ko01100,map00970,map01100 M00359,M00360 R03652 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1c,tRNA-synt_1c_C SRD1_k127_2259464_1 1191523.MROS_2831 4.682e-68 241.0 COG2908@1|root,COG2908@2|Bacteria 2|Bacteria M Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxH GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008758,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0019637,GO:0019897,GO:0019898,GO:0030145,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044425,GO:0044459,GO:0044464,GO:0046467,GO:0046493,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 3.6.1.54 ko:K03269 ko00540,ko01100,map00540,map01100 M00060 R04549 RC00002 ko00000,ko00001,ko00002,ko01000,ko01005 - - iE2348C_1286.E2348C_0457 Metallophos,Metallophos_2 SRD1_k127_2259464_0 1191523.MROS_2830 9.52e-207 666.0 COG5009@1|root,COG5009@2|Bacteria 2|Bacteria M serine-type D-Ala-D-Ala carboxypeptidase activity mrcA - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly,Transpeptidase SRD1_k127_2269201_4 745014.OMB55_00011410 4.234e-06 51.0 COG4447@1|root,COG4447@2|Bacteria,1MVIT@1224|Proteobacteria,1RZK1@1236|Gammaproteobacteria 1236|Gammaproteobacteria G K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit - - - - - - - - - - - - Sortilin-Vps10 SRD1_k127_2269201_0 382464.ABSI01000010_gene3492 3.006e-112 388.0 2DBYV@1|root,2ZBXC@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - SRD1_k127_2269201_3 1343740.M271_08750 1.55e-13 79.0 COG0524@1|root,COG0524@2|Bacteria,2GKQP@201174|Actinobacteria 201174|Actinobacteria G Carbohydrate kinase - - - - - - - - - - - - PfkB SRD1_k127_2269201_2 696281.Desru_3140 4.652e-20 96.0 COG0524@1|root,COG0524@2|Bacteria,1UW7Z@1239|Firmicutes,25MKR@186801|Clostridia,2660K@186807|Peptococcaceae 186801|Clostridia G pfkB family carbohydrate kinase - - - - - - - - - - - - PfkB SRD1_k127_2269201_1 1499967.BAYZ01000016_gene6546 3.991e-112 390.0 COG0383@1|root,COG0383@2|Bacteria,2NQ98@2323|unclassified Bacteria 2|Bacteria G Alpha mannosidase, middle domain mngB GO:0003674,GO:0003824,GO:0004553,GO:0004559,GO:0005975,GO:0005996,GO:0006013,GO:0006464,GO:0006517,GO:0006807,GO:0008150,GO:0008152,GO:0009100,GO:0009987,GO:0015923,GO:0016787,GO:0016798,GO:0019318,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0071704,GO:1901135,GO:1901564 2.3.1.204,3.2.1.170,3.2.1.24 ko:K01191,ko:K15524,ko:K16869 ko00511,map00511 - - - ko00000,ko00001,ko01000,ko04131 - GH38 iEcolC_1368.EcolC_2924,iSF_1195.SF0565,iSFxv_1172.SFxv_0623,iS_1188.S0578 Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C SRD1_k127_2277310_9 1122915.AUGY01000084_gene6194 7.124e-43 172.0 COG0584@1|root,COG0584@2|Bacteria,1V3W4@1239|Firmicutes,4HFNQ@91061|Bacilli,26SCR@186822|Paenibacillaceae 91061|Bacilli C glycerophosphoryl diester phosphodiesterase ugpQ_2 - 3.1.4.46 ko:K01126 ko00564,map00564 - R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 - - - GDPD SRD1_k127_2277310_7 521045.Kole_1881 2.073e-58 213.0 COG0563@1|root,COG0563@2|Bacteria,2GCW0@200918|Thermotogae 200918|Thermotogae F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism adk - 2.7.4.3 ko:K00939 ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 M00049 R00127,R01547,R11319 RC00002 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ADK,ADK_lid SRD1_k127_2277310_4 1191523.MROS_0421 1.092e-87 306.0 COG0820@1|root,COG0820@2|Bacteria 2|Bacteria J rRNA (adenine-C2-)-methyltransferase activity rlmN GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360 2.1.1.192 ko:K06941 - - - - ko00000,ko01000,ko03009 - - - Fer4_14,Radical_SAM SRD1_k127_2277310_3 1379698.RBG1_1C00001G0106 3.373e-97 327.0 COG0564@1|root,COG0564@2|Bacteria,2NNY5@2323|unclassified Bacteria 2|Bacteria J Responsible for synthesis of pseudouridine from uracil rluD GO:0000027,GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022607,GO:0022613,GO:0022618,GO:0031118,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042273,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360 5.4.99.23,5.4.99.28,5.4.99.29 ko:K06177,ko:K06180 - - - - ko00000,ko01000,ko03009,ko03016 - - iE2348C_1286.E2348C_2868,iECED1_1282.ECED1_3035,iECSF_1327.ECSF_2432 PseudoU_synth_2,S4 SRD1_k127_2277310_6 945713.IALB_0475 1.431e-59 211.0 COG0597@1|root,COG0597@2|Bacteria 2|Bacteria MU This protein specifically catalyzes the removal of signal peptides from prolipoproteins lspA - 3.4.23.36 ko:K03101 ko03060,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_A8 SRD1_k127_2277310_10 945713.IALB_0474 5.771e-33 135.0 COG1734@1|root,COG1734@2|Bacteria 2|Bacteria T zinc ion binding dksA - - ko:K06204 ko02026,map02026 - - - ko00000,ko00001,ko03000,ko03009,ko03021 - - - zf-dskA_traR SRD1_k127_2277310_0 945713.IALB_0473 0.0 1289.0 COG0060@1|root,COG0060@2|Bacteria 2|Bacteria J isoleucyl-tRNA aminoacylation ileS GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iG2583_1286.G2583_0027,iPC815.YPO0475 Anticodon_1,tRNA-synt_1,zf-FPG_IleRS SRD1_k127_2277310_12 338966.Ppro_1650 2.712e-16 84.0 COG3071@1|root,COG3071@2|Bacteria,1N6Y8@1224|Proteobacteria,42WU5@68525|delta/epsilon subdivisions,2WRRS@28221|Deltaproteobacteria,43SRB@69541|Desulfuromonadales 28221|Deltaproteobacteria H Protein of unknown function (DUF2905) - - - - - - - - - - - - DUF2905 SRD1_k127_2277310_1 945713.IALB_0471 1.214e-123 402.0 COG0005@1|root,COG0005@2|Bacteria 2|Bacteria F purine-nucleoside phosphorylase activity punA - 2.4.2.1 ko:K03783 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244 RC00033,RC00063,RC00122 ko00000,ko00001,ko01000 - - - PNP_UDP_1 SRD1_k127_2277310_11 1519464.HY22_02885 4.079e-29 124.0 COG3599@1|root,COG3599@2|Bacteria,1FF79@1090|Chlorobi 1090|Chlorobi D DivIVA protein - - - ko:K04074 - - - - ko00000,ko03036 - - - DivIVA SRD1_k127_2277310_5 264732.Moth_0858 5.618e-64 231.0 COG0325@1|root,COG0325@2|Bacteria,1TRDN@1239|Firmicutes,248R6@186801|Clostridia,42G1Y@68295|Thermoanaerobacterales 186801|Clostridia S Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis ylmE - - ko:K06997 - - - - ko00000 - - - Ala_racemase_N SRD1_k127_2277310_2 1191523.MROS_1323 9.255e-112 376.0 COG0457@1|root,COG0457@2|Bacteria 1191523.MROS_1323|- S peptidyl-tyrosine sulfation - - - - - - - - - - - - - SRD1_k127_2281757_3 1121405.dsmv_2920 1.425e-43 164.0 COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,42N6N@68525|delta/epsilon subdivisions,2WJ1W@28221|Deltaproteobacteria,2MJ8N@213118|Desulfobacterales 28221|Deltaproteobacteria C Respiratory-chain NADH dehydrogenase domain 51 kDa subunit - - 1.12.1.3,1.6.5.2,1.6.5.3 ko:K00124,ko:K00335,ko:K00355,ko:K05587,ko:K18331 ko00130,ko00190,ko00630,ko00680,ko01100,ko01110,ko01120,ko01200,ko05200,ko05225,ko05418,map00130,map00190,map00630,map00680,map01100,map01110,map01120,map01200,map05200,map05225,map05418 M00144 R00519,R02964,R03643,R03816,R11945 RC00061,RC00819,RC02796 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB SRD1_k127_2281757_0 1499967.BAYZ01000171_gene5565 4.677e-78 275.0 COG1148@1|root,COG1905@1|root,COG1148@2|Bacteria,COG1905@2|Bacteria,2NPSB@2323|unclassified Bacteria 2|Bacteria C Thioredoxin-like [2Fe-2S] ferredoxin bamG - 1.6.5.3,1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K00334,ko:K03388 ko00190,ko00680,ko01100,ko01120,ko01200,map00190,map00680,map01100,map01120,map01200 M00144,M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944,R11945 RC00011,RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx,Fer4,NAD_binding_8,Pyr_redox_2,Response_reg SRD1_k127_2281757_1 985053.VMUT_2339 6.25e-69 248.0 COG0247@1|root,COG2048@1|root,arCOG00964@2157|Archaea,arCOG05014@2157|Archaea 2157|Archaea C Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). HdrE may be responsible for anchoring the complex to the membrane hdrE GO:0003674,GO:0003824,GO:0005575,GO:0006091,GO:0008150,GO:0008152,GO:0009058,GO:0009061,GO:0009987,GO:0015947,GO:0015948,GO:0015975,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016667,GO:0031224,GO:0043446,GO:0043447,GO:0044237,GO:0044249,GO:0044425,GO:0045333,GO:0051912,GO:0055114,GO:0071704,GO:1901576 1.8.98.1 ko:K08265,ko:K16887 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 - R04540 RC00011 ko00000,ko00001,ko01000 - - - Fer4_17,Nitrate_red_gam SRD1_k127_2281757_2 243231.GSU2744 1.6e-55 201.0 COG0477@1|root,COG0477@2|Bacteria,1QWSX@1224|Proteobacteria,43C55@68525|delta/epsilon subdivisions,2X7FI@28221|Deltaproteobacteria 28221|Deltaproteobacteria EGP MFS/sugar transport protein - - - - - - - - - - - - MFS_1 SRD1_k127_2290735_2 1519464.HY22_03125 2.485e-10 67.0 COG1729@1|root,COG1729@2|Bacteria 2|Bacteria S protein trimerization - - - - - - - - - - - - TPR_16,TPR_21,TPR_6 SRD1_k127_2290735_1 1379698.RBG1_1C00001G0202 2.885e-113 376.0 COG1721@1|root,COG1721@2|Bacteria,2NP6B@2323|unclassified Bacteria 2|Bacteria S Protein of unknown function DUF58 - - - - - - - - - - - - DUF58 SRD1_k127_2290735_0 945713.IALB_2364 0.0 1299.0 COG0178@1|root,COG0178@2|Bacteria 2|Bacteria L nucleotide-excision repair uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran SRD1_k127_2291756_2 596152.DesU5LDRAFT_2269 7.671e-05 46.0 COG4122@1|root,COG4122@2|Bacteria,1PVDD@1224|Proteobacteria,43A83@68525|delta/epsilon subdivisions,2WYJN@28221|Deltaproteobacteria,2M9CP@213115|Desulfovibrionales 28221|Deltaproteobacteria S O-methyltransferase - - - - - - - - - - - - Methyltransf_3 SRD1_k127_2291756_1 204669.Acid345_2164 4.979e-40 158.0 COG2318@1|root,COG2318@2|Bacteria,3Y501@57723|Acidobacteria,2JJGU@204432|Acidobacteriia 204432|Acidobacteriia S DinB superfamily - - - - - - - - - - - - DinB_2 SRD1_k127_2291756_0 118163.Ple7327_3894 3.544e-77 269.0 COG0524@1|root,COG0524@2|Bacteria,1G0GK@1117|Cyanobacteria,3VI7C@52604|Pleurocapsales 1117|Cyanobacteria G PFAM pfkB family carbohydrate kinase - - - - - - - - - - - - PfkB SRD1_k127_2295126_1 1237149.C900_04877 7.865e-71 244.0 COG1131@1|root,COG1131@2|Bacteria,4NEH0@976|Bacteroidetes,47KF6@768503|Cytophagia 976|Bacteroidetes V TIGRFAM Gliding motility-associated ABC transporter ATP-binding subunit GldA gldA - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran SRD1_k127_2295126_2 1121904.ARBP01000029_gene2183 5.076e-60 231.0 COG0591@1|root,COG0591@2|Bacteria,4NJMV@976|Bacteroidetes,47MJA@768503|Cytophagia 976|Bacteroidetes E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - - - - - - - - - - SSF SRD1_k127_2295126_0 1079460.ATTQ01000010_gene80 3.967e-90 307.0 COG1172@1|root,COG1172@2|Bacteria,1PSTG@1224|Proteobacteria,2V7KK@28211|Alphaproteobacteria,4BCQS@82115|Rhizobiaceae 28211|Alphaproteobacteria G Branched-chain amino acid transport system / permease component - - - - - - - - - - - - BPD_transp_2 SRD1_k127_231354_0 1125863.JAFN01000001_gene2915 5.887e-174 554.0 COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,42MBF@68525|delta/epsilon subdivisions,2WJQ2@28221|Deltaproteobacteria 28221|Deltaproteobacteria H PFAM Aminotransferase class-III hemL - 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 SRD1_k127_231354_3 880072.Desac_0134 9.345e-50 181.0 COG1881@1|root,COG1881@2|Bacteria,1N0Y4@1224|Proteobacteria,42WMA@68525|delta/epsilon subdivisions,2WRGN@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Phosphatidylethanolamine-binding protein - - - ko:K06910 - - - - ko00000 - - - PBP SRD1_k127_231354_2 646529.Desaci_0410 1.065e-90 310.0 COG0579@1|root,COG0579@2|Bacteria,1TRDH@1239|Firmicutes,248IK@186801|Clostridia 186801|Clostridia P FAD dependent oxidoreductase - - 1.1.5.3 ko:K00111 ko00564,ko01110,map00564,map01110 - R00848 RC00029 ko00000,ko00001,ko01000 - - - DAO,Fer2_BFD SRD1_k127_231354_4 278963.ATWD01000002_gene614 3.363e-13 80.0 COG0560@1|root,COG0560@2|Bacteria,3Y3RE@57723|Acidobacteria,2JI0Y@204432|Acidobacteriia 204432|Acidobacteriia E haloacid dehalogenase-like hydrolase - - - - - - - - - - - - HAD SRD1_k127_231354_1 1519464.HY22_07070 1.204e-118 388.0 COG0481@1|root,COG0481@2|Bacteria,1FDSU@1090|Chlorobi 1090|Chlorobi J Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner lepA - - ko:K03596 ko05134,map05134 - - - ko00000,ko00001 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C SRD1_k127_2338991_5 321327.CYA_1206 1.173e-10 63.0 COG0031@1|root,COG0031@2|Bacteria,1GBK3@1117|Cyanobacteria,1H00H@1129|Synechococcus 1117|Cyanobacteria E Pyridoxal-phosphate dependent enzyme - - 2.5.1.47 ko:K12339 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03132,R03601,R04859 RC00020,RC02814,RC02821,RC02876 ko00000,ko00001,ko00002,ko01000 - - - PALP SRD1_k127_2338991_4 55207.KP22_14560 8.42e-35 138.0 COG1310@1|root,COG1310@2|Bacteria,1QRZQ@1224|Proteobacteria,1S558@1236|Gammaproteobacteria 1236|Gammaproteobacteria S JAB1/Mov34/MPN/PAD-1 ubiquitin protease - - - - - - - - - - - - Prok-JAB SRD1_k127_2338991_0 1267535.KB906767_gene1049 3.988e-192 615.0 COG0476@1|root,COG0607@1|root,COG0476@2|Bacteria,COG0607@2|Bacteria,3Y3IF@57723|Acidobacteria,2JIPC@204432|Acidobacteriia 204432|Acidobacteriia HP PFAM UBA THIF-type NAD FAD binding - - 2.7.7.80,2.8.1.11 ko:K21147 ko04122,map04122 - R07459,R07461 RC00043 ko00000,ko00001,ko01000 - - - Rhodanese,ThiF,ThiS SRD1_k127_2338991_2 945713.IALB_3108 1.489e-54 204.0 COG2010@1|root,COG2010@2|Bacteria 2|Bacteria C Cytochrome c cccE - - - - - - - - - - - Cytochrom_C,Cytochrome_CBB3 SRD1_k127_2338991_3 671143.DAMO_1668 6.198e-38 153.0 COG3794@1|root,COG3794@2|Bacteria,2NR3M@2323|unclassified Bacteria 2|Bacteria C PFAM blue (type 1) copper domain protein - - - - - - - - - - - - CarboxypepD_reg,fn3_3 SRD1_k127_2338991_1 880073.Calab_1563 3.117e-121 429.0 COG1629@1|root,COG1629@2|Bacteria,2NS4U@2323|unclassified Bacteria 2|Bacteria P PFAM TonB-dependent Receptor Plug Domain - - - - - - - - - - - - CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_dep_Rec SRD1_k127_2354688_1 880073.Calab_0034 8.997e-91 312.0 COG3408@1|root,COG3408@2|Bacteria,2NPVQ@2323|unclassified Bacteria 2|Bacteria G Trehalase - - - ko:K03931 - - - - ko00000 - GH63 - Glyco_hydro_63,Trehalase SRD1_k127_2354688_0 1382359.JIAL01000001_gene686 2.19e-125 432.0 COG3408@1|root,COG3408@2|Bacteria 2|Bacteria G Glycogen debranching enzyme - - 3.2.1.187 ko:K18206 - - - - ko00000,ko01000 - GH121 - Big_4,F5_F8_type_C,FIVAR,Laminin_G_3,SLH SRD1_k127_2359161_1 926569.ANT_25570 2.207e-21 96.0 COG0210@1|root,COG0210@2|Bacteria,2G5XF@200795|Chloroflexi 200795|Chloroflexi L PFAM UvrD REP helicase pcrA - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C SRD1_k127_2359161_0 1267535.KB906767_gene4461 4.5e-150 480.0 COG0667@1|root,COG0667@2|Bacteria,3Y35T@57723|Acidobacteria,2JK73@204432|Acidobacteriia 204432|Acidobacteriia C Aldo/keto reductase family - - - - - - - - - - - - Aldo_ket_red SRD1_k127_238227_0 945713.IALB_2012 1.248e-154 503.0 COG2204@1|root,COG2204@2|Bacteria 2|Bacteria T phosphorelay signal transduction system ntrX - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat SRD1_k127_238227_1 1118054.CAGW01000092_gene3593 1.684e-68 248.0 COG0566@1|root,COG0566@2|Bacteria,1TP9G@1239|Firmicutes,4HBBI@91061|Bacilli,26RQZ@186822|Paenibacillaceae 91061|Bacilli J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family trmH GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070039,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.185 ko:K03218 - - - - ko00000,ko01000,ko03009 - - - SpoU_methylase,SpoU_sub_bind SRD1_k127_238227_2 1519464.HY22_14250 6.729e-24 107.0 COG0682@1|root,COG0682@2|Bacteria 2|Bacteria M lipoprotein biosynthetic process lgt - - ko:K13292 - - - - ko00000,ko01000 - - - LGT SRD1_k127_2384076_1 1095769.CAHF01000006_gene1926 2.452e-84 287.0 COG0177@1|root,COG0177@2|Bacteria,1MUYQ@1224|Proteobacteria,2VIRB@28216|Betaproteobacteria,476N7@75682|Oxalobacteraceae 28216|Betaproteobacteria L endonuclease III - - - - - - - - - - - - HhH-GPD SRD1_k127_2384076_2 1254432.SCE1572_35515 1.351e-15 82.0 COG5649@1|root,COG5649@2|Bacteria 2|Bacteria E Domain of unknown function (DU1801) - - - - - - - - - - - - DUF1801 SRD1_k127_2384076_0 1191523.MROS_2824 7.011e-112 368.0 COG0504@1|root,COG0504@2|Bacteria 2|Bacteria F CTP synthase activity pyrG GO:0001775,GO:0002376,GO:0003674,GO:0003824,GO:0003883,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006241,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008283,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009208,GO:0009209,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016020,GO:0016874,GO:0016879,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032943,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042098,GO:0042100,GO:0042110,GO:0042113,GO:0042221,GO:0042455,GO:0042493,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045321,GO:0046036,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046649,GO:0046651,GO:0050896,GO:0055086,GO:0070661,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_1276,iECO103_1326.ECO103_3323,iNJ661.Rv1699,iPC815.YPO3377 CTP_synth_N,GATase SRD1_k127_2404477_2 1519464.HY22_00515 7.917e-99 337.0 COG2366@1|root,COG2366@2|Bacteria,1FF0M@1090|Chlorobi 1090|Chlorobi S Penicillin amidase - - 3.5.1.11 ko:K01434 ko00311,ko01130,map00311,map01130 - R02170 RC00166,RC00328 ko00000,ko00001,ko01000,ko01002 - - - Penicil_amidase SRD1_k127_2404477_3 518766.Rmar_2323 1.255e-81 289.0 COG0846@1|root,COG0846@2|Bacteria,4NE9Q@976|Bacteroidetes,1FIMG@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes K NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form - - - ko:K12410 - - - - ko00000,ko01000 - - - SIR2 SRD1_k127_2404477_1 760568.Desku_1651 6.237e-133 439.0 COG0469@1|root,COG0469@2|Bacteria,1TPGG@1239|Firmicutes,2489V@186801|Clostridia,260WY@186807|Peptococcaceae 186801|Clostridia G Belongs to the pyruvate kinase family pyk - 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - PEP-utilizers,PK,PK_C SRD1_k127_2404477_4 945713.IALB_0371 8.766e-17 85.0 COG1366@1|root,COG1366@2|Bacteria 2|Bacteria T antisigma factor binding - - - ko:K04749,ko:K06378 - - - - ko00000,ko03021 - - - STAS,STAS_2 SRD1_k127_2404477_0 880073.Calab_3750 5.694e-222 706.0 COG0272@1|root,COG0272@2|Bacteria,2NNSW@2323|unclassified Bacteria 2|Bacteria L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA ligA GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 6.5.1.2 ko:K01972,ko:K10754 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 M00289,M00295 R00382 RC00005 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5 SRD1_k127_2404477_5 1329250.WOSG25_030850 7.602e-09 67.0 COG1426@1|root,COG1426@2|Bacteria,1V1N7@1239|Firmicutes,4HKW3@91061|Bacilli,4AX0U@81850|Leuconostocaceae 91061|Bacilli S protein conserved in bacteria ymfM - - ko:K15539 - - - - ko00000 - - - DUF4115,HTH_25 SRD1_k127_2404477_7 909663.KI867150_gene410 1.796e-06 54.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MFW@68525|delta/epsilon subdivisions,2WKMP@28221|Deltaproteobacteria,2MQVW@213462|Syntrophobacterales 28221|Deltaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_9,Response_reg SRD1_k127_240742_4 1123355.JHYO01000002_gene1347 5.297e-08 65.0 COG1277@1|root,COG1277@2|Bacteria,1MWUZ@1224|Proteobacteria,2U10D@28211|Alphaproteobacteria,37064@31993|Methylocystaceae 28211|Alphaproteobacteria S ABC-2 family transporter protein nosY - - ko:K01992,ko:K19341 ko02010,map02010 M00254,M00762 - - ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.132.2 - - ABC2_membrane_2 SRD1_k127_240742_1 1122931.AUAE01000013_gene2072 1.407e-95 320.0 COG1131@1|root,COG1131@2|Bacteria,4NE3Z@976|Bacteroidetes,2FR55@200643|Bacteroidia,22ZR5@171551|Porphyromonadaceae 976|Bacteroidetes V AAA domain, putative AbiEii toxin, Type IV TA system - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran SRD1_k127_240742_2 1235803.C825_05283 2.638e-72 260.0 COG3852@1|root,COG3852@2|Bacteria,4PPPV@976|Bacteroidetes,2G17D@200643|Bacteroidia,22ZVH@171551|Porphyromonadaceae 976|Bacteroidetes T GAF domain - - - - - - - - - - - - HATPase_c,HisKA SRD1_k127_240742_0 429009.Adeg_0173 3.39e-117 398.0 COG2204@1|root,COG2204@2|Bacteria,1VSKG@1239|Firmicutes,24ZP4@186801|Clostridia,42J66@68295|Thermoanaerobacterales 186801|Clostridia T PFAM sigma-54 factor interaction domain-containing protein - - - ko:K02481,ko:K07714,ko:K10943 ko02020,ko05111,map02020,map05111 M00500,M00515 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat SRD1_k127_240742_3 1047013.AQSP01000142_gene196 3.003e-15 78.0 2EFWM@1|root,339NX@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - SRD1_k127_2424410_1 290397.Adeh_2849 7.505e-57 211.0 COG0697@1|root,COG0697@2|Bacteria,1PX5W@1224|Proteobacteria,42MGR@68525|delta/epsilon subdivisions,2X5KV@28221|Deltaproteobacteria,2YY40@29|Myxococcales 28221|Deltaproteobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA SRD1_k127_2424410_0 1121104.AQXH01000001_gene1224 2.033e-76 280.0 COG0438@1|root,COG0438@2|Bacteria,4NM8R@976|Bacteroidetes 976|Bacteroidetes M Glycosyl transferases group 1 - - - - - - - - - - - - Glycos_transf_1 SRD1_k127_2424410_2 1121930.AQXG01000003_gene2517 6.563e-35 146.0 COG0726@1|root,COG0726@2|Bacteria 2|Bacteria G polysaccharide deacetylase - - - - - - - - - - - - Polysacc_deac_1 SRD1_k127_2434103_1 264732.Moth_0417 3.253e-28 120.0 COG1414@1|root,COG1414@2|Bacteria,1TRMW@1239|Firmicutes,24BQA@186801|Clostridia,42G3H@68295|Thermoanaerobacterales 186801|Clostridia K Transcriptional regulator IclR kdgR - - ko:K13641 - - - - ko00000,ko03000 - - - HTH_IclR,IclR SRD1_k127_2434103_0 1120965.AUBV01000001_gene3407 8.188e-80 277.0 COG0520@1|root,COG0520@2|Bacteria,4NF4G@976|Bacteroidetes,47M48@768503|Cytophagia 976|Bacteroidetes E Aminotransferase class-V - - - - - - - - - - - - Aminotran_5 SRD1_k127_2455226_1 515635.Dtur_1733 2.325e-107 353.0 COG2407@1|root,COG2407@2|Bacteria 2|Bacteria G Converts the aldose L-fucose into the corresponding ketose L-fuculose - - - - - - - - - - - - Fucose_iso_C SRD1_k127_2455226_2 929703.KE386492_gene4303 2.085e-91 306.0 COG0235@1|root,COG0235@2|Bacteria,4NGMP@976|Bacteroidetes,47MSX@768503|Cytophagia 976|Bacteroidetes G PFAM Class II Aldolase and Adducin N-terminal domain araD - 5.1.3.4 ko:K03077 ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120 M00550 R05850 RC01479 ko00000,ko00001,ko00002,ko01000 - - - Aldolase_II SRD1_k127_2455226_0 1168034.FH5T_00630 3.598e-235 739.0 COG1069@1|root,COG1069@2|Bacteria,4NEFQ@976|Bacteroidetes,2FNNI@200643|Bacteroidia 976|Bacteroidetes G Belongs to the ribulokinase family araB - 2.7.1.16 ko:K00853 ko00040,ko01100,map00040,map01100 - R01526,R02439 RC00002,RC00538 ko00000,ko00001,ko01000 - - - FGGY_C,FGGY_N SRD1_k127_2455226_3 411684.HPDFL43_01950 5.022e-19 89.0 COG1879@1|root,COG1879@2|Bacteria,1PJTT@1224|Proteobacteria,2V9UM@28211|Alphaproteobacteria,43PW4@69277|Phyllobacteriaceae 28211|Alphaproteobacteria G Periplasmic binding protein domain - - - - - - - - - - - - Peripla_BP_4 SRD1_k127_2465277_0 1089550.ATTH01000001_gene2172 2.329e-162 524.0 COG0305@1|root,COG0305@2|Bacteria,4NF8P@976|Bacteroidetes,1FIJX@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes L Participates in initiation and elongation during chromosome replication dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C SRD1_k127_2465277_4 945713.IALB_0710 1.193e-73 262.0 COG1573@1|root,COG1573@2|Bacteria 2|Bacteria L deaminated base DNA N-glycosylase activity ung - 3.2.2.27 ko:K21929 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG SRD1_k127_2465277_1 518766.Rmar_0013 3.826e-124 413.0 COG0452@1|root,COG0452@2|Bacteria,4NE46@976|Bacteroidetes,1FIJM@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine coaBC - 4.1.1.36,6.3.2.5 ko:K13038 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 - - - DFP,Flavoprotein SRD1_k127_2465277_7 1168034.FH5T_17545 0.0001975 48.0 2CT4B@1|root,32SSJ@2|Bacteria,4NQ76@976|Bacteroidetes,2FUCD@200643|Bacteroidia 976|Bacteroidetes K Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits rpoZ - - - - - - - - - - - RNA_pol_Rpb6 SRD1_k127_2465277_6 1519464.HY22_04405 2.233e-52 190.0 COG0194@1|root,COG0194@2|Bacteria,1FDYT@1090|Chlorobi 1090|Chlorobi F Essential for recycling GMP and indirectly, cGMP gmk - 2.7.4.8 ko:K00942 ko00230,ko01100,map00230,map01100 M00050 R00332,R02090 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_kin SRD1_k127_2465277_3 1519464.HY22_04400 4.782e-77 270.0 COG1561@1|root,COG1561@2|Bacteria,1FDEB@1090|Chlorobi 1090|Chlorobi S PFAM YicC domain protein - - - - - - - - - - - - DUF1732,YicC_N SRD1_k127_2465277_2 518766.Rmar_2635 7.746e-86 304.0 COG1293@1|root,COG1293@2|Bacteria,4NGP5@976|Bacteroidetes,1FJ0X@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes K Fibronectin-binding protein A N-terminus (FbpA) - - - - - - - - - - - - DUF814,FbpA SRD1_k127_2465277_5 926690.KE386573_gene2579 1.095e-58 218.0 COG1893@1|root,arCOG04139@2157|Archaea,2XW0P@28890|Euryarchaeota,23S7V@183963|Halobacteria 183963|Halobacteria H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid - - 1.1.1.169 ko:K00077 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R02472 RC00726 ko00000,ko00001,ko00002,ko01000 - - - ApbA,ApbA_C SRD1_k127_2487004_0 358681.BBR47_01890 3.198e-166 534.0 COG1066@1|root,COG1066@2|Bacteria,1TQ7Y@1239|Firmicutes,4H9YC@91061|Bacilli,26QQ5@186822|Paenibacillaceae 91061|Bacilli O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function radA - - ko:K04485 - - - - ko00000,ko03400 - - - AAA_25,ATPase,ChlI SRD1_k127_2487004_2 632518.Calow_0685 1.191e-56 204.0 COG0127@1|root,COG0127@2|Bacteria,1V6RN@1239|Firmicutes,249GK@186801|Clostridia,42GAD@68295|Thermoanaerobacterales 186801|Clostridia F Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions rdgB - 3.6.1.66 ko:K02428 ko00230,map00230 - R00426,R00720,R01855,R02100,R02720,R03531 RC00002 ko00000,ko00001,ko01000 - - - Ham1p_like SRD1_k127_2487004_4 756067.MicvaDRAFT_1381 2.744e-46 180.0 COG5190@1|root,COG5190@2|Bacteria,1G5PJ@1117|Cyanobacteria,1HEF4@1150|Oscillatoriales 1117|Cyanobacteria K PFAM NLI interacting factor - - - - - - - - - - - - NIF SRD1_k127_2487004_3 443144.GM21_1874 2.828e-54 194.0 COG0394@1|root,COG0394@2|Bacteria,1MWYQ@1224|Proteobacteria,42SQK@68525|delta/epsilon subdivisions,2WPK1@28221|Deltaproteobacteria 28221|Deltaproteobacteria T PFAM Protein-tyrosine phosphatase, low molecular weight - - 1.20.4.1 ko:K03741 - - - - ko00000,ko01000 - - - LMWPc SRD1_k127_2487004_1 290512.Paes_1119 1.036e-112 368.0 COG0798@1|root,COG0798@2|Bacteria,1FDU0@1090|Chlorobi 1090|Chlorobi P PFAM Bile acid sodium symporter - - - ko:K03325 - - - - ko00000,ko02000 2.A.59 - - SBF SRD1_k127_2503417_0 96561.Dole_1818 8.505e-163 526.0 COG0677@1|root,COG0677@2|Bacteria,1MUC6@1224|Proteobacteria,42M4F@68525|delta/epsilon subdivisions,2WJEW@28221|Deltaproteobacteria,2MHRR@213118|Desulfobacterales 28221|Deltaproteobacteria M Belongs to the UDP-glucose GDP-mannose dehydrogenase family capL - 1.1.1.136,1.1.1.336 ko:K02472,ko:K02474,ko:K13015 ko00520,ko05111,map00520,map05111 - R00421,R03317,R06894 RC00291 ko00000,ko00001,ko01000,ko01005 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N SRD1_k127_2503417_2 419610.Mext_3569 1.885e-20 104.0 COG0438@1|root,COG0438@2|Bacteria,1Q1CU@1224|Proteobacteria,2UW3F@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Glycosyl transferase 4-like domain - - - - - - - - - - - - Glyco_trans_1_4,Glyco_transf_4 SRD1_k127_2503417_1 1313265.JNIE01000002_gene889 6.036e-120 395.0 COG0367@1|root,COG0367@2|Bacteria 2|Bacteria E asparagine synthase asnB - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 SRD1_k127_2505139_3 1123405.AUMM01000003_gene545 1.896e-45 171.0 COG2318@1|root,COG2318@2|Bacteria,1V6MV@1239|Firmicutes,4HH68@91061|Bacilli 91061|Bacilli S Squalene--hopene cyclase - - - - - - - - - - - - DinB_2 SRD1_k127_2505139_1 99598.Cal7507_6086 6.778e-80 274.0 COG3548@1|root,COG3548@2|Bacteria,1GKP7@1117|Cyanobacteria,1HRK3@1161|Nostocales 1117|Cyanobacteria S Protein of unknown function (DUF1211) - - - - - - - - - - - - DUF1211 SRD1_k127_2505139_4 580332.Slit_0335 4.843e-43 162.0 arCOG05276@1|root,3195F@2|Bacteria,1RHZA@1224|Proteobacteria,2VSYY@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - SRD1_k127_2505139_0 1499967.BAYZ01000095_gene4075 1.28e-95 324.0 COG2220@1|root,COG2220@2|Bacteria,2NQD1@2323|unclassified Bacteria 2|Bacteria S Beta-lactamase superfamily domain - - - - - - - - - - - - Lactamase_B_3 SRD1_k127_2505139_2 1123401.JHYQ01000008_gene406 3.663e-57 215.0 COG3325@1|root,COG3325@2|Bacteria 2|Bacteria G chitin binding - - 3.2.1.14 ko:K01183 ko00520,ko01100,map00520,map01100 - R01206,R02334 RC00467 ko00000,ko00001,ko01000 - GH18 - Calx-beta,Glyco_hydro_18,PA14,PKD,fn3 SRD1_k127_2513143_0 517418.Ctha_0775 6.62e-188 608.0 COG0457@1|root,COG0697@1|root,COG0457@2|Bacteria,COG0697@2|Bacteria,1FDC1@1090|Chlorobi 1090|Chlorobi EG Protein of unknown function (DUF2723) - - - - - - - - - - - - DUF2723 SRD1_k127_2513143_1 880073.Calab_1876 5.367e-103 347.0 COG0635@1|root,COG0635@2|Bacteria,2NP4Y@2323|unclassified Bacteria 2|Bacteria H Involved in the biosynthesis of porphyrin-containing compound hemN - - - - - - - - - - - HemN_C,Radical_SAM SRD1_k127_2513143_3 330214.NIDE2552 7.749e-25 113.0 COG0681@1|root,COG0681@2|Bacteria,3J0IP@40117|Nitrospirae 40117|Nitrospirae U Signal peptidase, peptidase S26 lepB - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24 SRD1_k127_2513143_2 319225.Plut_1470 3.415e-44 163.0 COG0681@1|root,COG0681@2|Bacteria,1FDIZ@1090|Chlorobi 1090|Chlorobi U Belongs to the peptidase S26 family - - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24,Peptidase_S26 SRD1_k127_2516194_0 1144275.COCOR_04452 8.375e-239 751.0 COG1164@1|root,COG1164@2|Bacteria,1Q3C4@1224|Proteobacteria,4393F@68525|delta/epsilon subdivisions,2X49B@28221|Deltaproteobacteria,2YYJ7@29|Myxococcales 28221|Deltaproteobacteria E Oligoendopeptidase f - - - - - - - - - - - - - SRD1_k127_2516194_1 269798.CHU_3620 4.236e-45 172.0 COG0457@1|root,COG0457@2|Bacteria 269798.CHU_3620|- S peptidyl-tyrosine sulfation - - - - - - - - - - - - - SRD1_k127_2521609_3 349161.Dred_2954 5.792e-21 102.0 COG0845@1|root,COG0845@2|Bacteria,1V036@1239|Firmicutes,248P9@186801|Clostridia,2656V@186807|Peptococcaceae 186801|Clostridia M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 SRD1_k127_2521609_4 439235.Dalk_4861 1.606e-16 93.0 COG1538@1|root,COG1538@2|Bacteria,1PYD8@1224|Proteobacteria,42P1Y@68525|delta/epsilon subdivisions,2WKZG@28221|Deltaproteobacteria,2MMSN@213118|Desulfobacterales 28221|Deltaproteobacteria MU Outer membrane efflux protein - - - ko:K12340 ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133 M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko02044 1.B.17,2.A.6.2 - - OEP SRD1_k127_2521609_2 1121904.ARBP01000010_gene2416 1.609e-30 130.0 COG1309@1|root,COG1309@2|Bacteria,4NTB4@976|Bacteroidetes,47RD7@768503|Cytophagia 976|Bacteroidetes K PFAM Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N,WHG SRD1_k127_2521609_0 926549.KI421517_gene2964 5.256e-236 752.0 COG3590@1|root,COG3590@2|Bacteria,4NEYB@976|Bacteroidetes,47JHJ@768503|Cytophagia 976|Bacteroidetes O PFAM peptidase M13 pepO - - ko:K07386 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M13,Peptidase_M13_N SRD1_k127_2521609_1 945713.IALB_2692 2.074e-83 285.0 COG3250@1|root,COG3250@2|Bacteria 2|Bacteria G beta-galactosidase activity - - 3.1.1.53 ko:K05970 - - - - ko00000,ko01000 - - - BetaGal_dom4_5,F5_F8_type_C SRD1_k127_2546264_1 880073.Calab_3009 1.127e-72 267.0 COG2208@1|root,COG2208@2|Bacteria,2NQW9@2323|unclassified Bacteria 2|Bacteria KT Sigma factor PP2C-like phosphatases rsbU - 3.1.3.3,4.6.1.1 ko:K01768,ko:K07315 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000,ko03021 - - - CHASE2,GAF_2,HATPase_c_2,SpoIIE SRD1_k127_2546264_2 47763.JNZA01000004_gene3680 1.053e-25 117.0 COG2227@1|root,COG2227@2|Bacteria 2|Bacteria H 3-demethylubiquinone-9 3-O-methyltransferase activity - - - - - - - - - - - - Methyltransf_25 SRD1_k127_2546264_0 338963.Pcar_1613 1.013e-139 453.0 COG0505@1|root,COG0505@2|Bacteria,1MUB9@1224|Proteobacteria,42KZG@68525|delta/epsilon subdivisions,2WIQ5@28221|Deltaproteobacteria,43SCX@69541|Desulfuromonadales 28221|Deltaproteobacteria F Carbamoyl-phosphate synthase small chain, CPSase domain carA - 6.3.5.5 ko:K01956 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_sm_chain,GATase SRD1_k127_2546264_3 1120983.KB894575_gene673 4.539e-20 94.0 COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2TR49@28211|Alphaproteobacteria,1JND8@119043|Rhodobiaceae 28211|Alphaproteobacteria E Gamma-glutamyltranspeptidase ggt - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept SRD1_k127_2582096_0 945713.IALB_2222 4.46e-92 315.0 COG2217@1|root,COG2217@2|Bacteria 2|Bacteria P Heavy metal translocating P-type atpase - - 3.6.3.4,3.6.3.54 ko:K01533,ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase,YHS SRD1_k127_2582096_7 909663.KI867150_gene615 1.151e-10 65.0 COG2608@1|root,COG2608@2|Bacteria 2|Bacteria P mercury ion transmembrane transporter activity - - - ko:K07213 ko04978,map04978 - - - ko00000,ko00001 - - - HMA SRD1_k127_2582096_1 945713.IALB_2287 1.757e-55 201.0 COG1595@1|root,COG1595@2|Bacteria 2|Bacteria K DNA-templated transcription, initiation sigH GO:0000988,GO:0000990,GO:0003674,GO:0005575,GO:0005618,GO:0005623,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0016987,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0033554,GO:0034605,GO:0043254,GO:0044087,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0051409,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2000142,GO:2001141 - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 SRD1_k127_2582096_8 9986.ENSOCUP00000013308 2.018e-05 57.0 COG0457@1|root,KOG1124@2759|Eukaryota,KOG1126@2759|Eukaryota,38DM6@33154|Opisthokonta,3BEU3@33208|Metazoa,3CW6P@33213|Bilateria,485D1@7711|Chordata,48XAY@7742|Vertebrata,3J72H@40674|Mammalia,35IEN@314146|Euarchontoglires 33208|Metazoa O tetratricopeptide repeat TTC6 - - - - - - - - - - - TPR_1,TPR_11,TPR_16,TPR_2,TPR_8 SRD1_k127_2582096_6 929556.Solca_3742 3.276e-29 130.0 COG0226@1|root,COG0226@2|Bacteria,4NH1N@976|Bacteroidetes,1IRT8@117747|Sphingobacteriia 976|Bacteroidetes P ABC-type phosphate transport system periplasmic - - - ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - PBP_like_2 SRD1_k127_2582096_5 1379698.RBG1_1C00001G1358 4.264e-34 141.0 COG0810@1|root,COG0810@2|Bacteria,2NQ1D@2323|unclassified Bacteria 2|Bacteria M Gram-negative bacterial TonB protein C-terminal - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - CarbopepD_reg_2,TonB_C SRD1_k127_2582096_3 1519464.HY22_12045 1.441e-35 141.0 COG0848@1|root,COG0848@2|Bacteria,1FE26@1090|Chlorobi 1090|Chlorobi U PFAM Biopolymer transport protein ExbD TolR - - - - - - - - - - - - ExbD SRD1_k127_2582096_4 517418.Ctha_2331 2.684e-34 136.0 COG0848@1|root,COG0848@2|Bacteria,1FDZ1@1090|Chlorobi 1090|Chlorobi U Outer membrane transport energization protein ExbD - - - - - - - - - - - - ExbD SRD1_k127_2582096_2 517418.Ctha_2332 6.11e-42 156.0 COG0811@1|root,COG0811@2|Bacteria,1FDN2@1090|Chlorobi 1090|Chlorobi U PFAM MotA TolQ ExbB proton channel - - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB SRD1_k127_2626443_1 1380390.JIAT01000014_gene6288 1.27e-12 79.0 COG0028@1|root,COG0515@1|root,COG1470@1|root,COG2133@1|root,COG3291@1|root,COG0028@2|Bacteria,COG0515@2|Bacteria,COG1470@2|Bacteria,COG2133@2|Bacteria,COG3291@2|Bacteria 2|Bacteria S metallopeptidase activity - - 4.1.3.1 ko:K01637 ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200 M00012 R00479 RC00311,RC00313 ko00000,ko00001,ko00002,ko01000 - - - Calx-beta,DUF4347,GSDH,Laminin_G_3,PA14,PKD SRD1_k127_2626443_0 1499967.BAYZ01000102_gene3584 3.679e-38 144.0 COG0407@1|root,COG0407@2|Bacteria 2|Bacteria H Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III - - 4.1.1.37 ko:K01599 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000 - - - URO-D SRD1_k127_2637041_6 1033802.SSPSH_002156 2.152e-07 61.0 COG3147@1|root,COG3147@2|Bacteria 2|Bacteria S peptidoglycan binding - - - - - - - - - - - - SPOR SRD1_k127_2637041_2 1499967.BAYZ01000017_gene6221 1.485e-103 356.0 COG2148@1|root,COG2148@2|Bacteria,2NP0Q@2323|unclassified Bacteria 2|Bacteria M Bacterial sugar transferase wcaJ - - ko:K03606 ko05111,map05111 - - - ko00000,ko00001 - - - Bac_transf,CoA_binding_3 SRD1_k127_2637041_3 1191523.MROS_1442 3.411e-60 215.0 COG0279@1|root,COG0279@2|Bacteria 2|Bacteria G D-glycero-D-manno-heptose 7-phosphate metabolic process gmhA - 5.3.1.28 ko:K03271 ko00540,ko01100,map00540,map01100 M00064 R05645,R09768,R09769 RC00434 ko00000,ko00001,ko00002,ko01000,ko01005 - - - HupF_HypC,SIS_2 SRD1_k127_2637041_1 945713.IALB_0035 1.228e-301 950.0 COG0013@1|root,COG0013@2|Bacteria 2|Bacteria J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD SRD1_k127_2637041_4 309807.SRU_0964 4.908e-25 107.0 COG2127@1|root,COG2127@2|Bacteria,4PERZ@976|Bacteroidetes,1FJHS@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S ATP-dependent Clp protease adaptor protein ClpS - - - - - - - - - - - - ClpS SRD1_k127_2637041_0 945713.IALB_2872 0.0 1109.0 COG1048@1|root,COG1048@2|Bacteria 2|Bacteria C aconitate hydratase activity acnA - 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C SRD1_k127_2646559_6 1262449.CP6013_0770 2.693e-07 62.0 COG0457@1|root,COG3266@1|root,COG4676@1|root,COG4870@1|root,COG0457@2|Bacteria,COG3266@2|Bacteria,COG4676@2|Bacteria,COG4870@2|Bacteria,1VDA3@1239|Firmicutes 1239|Firmicutes O Protein conserved in bacteria - - - - - - - - - - - - CarboxypepD_reg,Flg_new,TPR_19 SRD1_k127_2646559_2 1519464.HY22_13055 2.96e-23 112.0 COG0265@1|root,COG0366@1|root,COG0265@2|Bacteria,COG0366@2|Bacteria 2|Bacteria G hydrolase activity, hydrolyzing O-glycosyl compounds - - 3.4.21.50 ko:K01337 - - - - ko00000,ko01000,ko01002 - - - Alpha-amylase SRD1_k127_2646559_5 335541.Swol_1992 5.606e-14 86.0 COG1409@1|root,COG1409@2|Bacteria,1TSSR@1239|Firmicutes,248DJ@186801|Clostridia 186801|Clostridia O PFAM Metallophosphoesterase - - - - - - - - - - - - Cu_amine_oxidN1,Metallophos,Pur_ac_phosph_N SRD1_k127_2646559_4 1121938.AUDY01000009_gene2251 1.407e-14 88.0 COG3266@1|root,COG3266@2|Bacteria,1VDA3@1239|Firmicutes,4ITGR@91061|Bacilli 91061|Bacilli S Protein conserved in bacteria - - - - - - - - - - - - Flg_new SRD1_k127_2646559_3 1121930.AQXG01000001_gene1166 3.863e-16 93.0 COG1404@1|root,COG1404@2|Bacteria,4NVH2@976|Bacteroidetes 976|Bacteroidetes O Belongs to the peptidase S8 family - - - - - - - - - - - - - SRD1_k127_2646559_0 880073.Calab_0640 4.093e-268 845.0 COG0591@1|root,COG0591@2|Bacteria 2|Bacteria E symporter activity - - - - - - - - - - - - SSF SRD1_k127_2646559_1 880073.Calab_0638 1.8e-114 379.0 COG1609@1|root,COG1609@2|Bacteria 2|Bacteria K purine nucleotide biosynthetic process - - - ko:K02103,ko:K05499 - - - - ko00000,ko03000 - - - GntR,Peripla_BP_1,Peripla_BP_3 SRD1_k127_2648702_2 177437.HRM2_24220 2.117e-58 210.0 COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,42Q40@68525|delta/epsilon subdivisions,2WKJ7@28221|Deltaproteobacteria,2MK6F@213118|Desulfobacterales 28221|Deltaproteobacteria K helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE,Response_reg SRD1_k127_2648702_1 1304885.AUEY01000045_gene255 2.695e-60 229.0 COG3437@1|root,COG4191@1|root,COG3437@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42M1R@68525|delta/epsilon subdivisions,2WK3J@28221|Deltaproteobacteria,2MI5F@213118|Desulfobacterales 28221|Deltaproteobacteria T histidine kinase A domain protein - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg SRD1_k127_2648702_0 1191523.MROS_1950 1.863e-149 486.0 COG2204@1|root,COG2204@2|Bacteria 2|Bacteria T phosphorelay signal transduction system - - - ko:K07713,ko:K07714 ko02020,map02020 M00499,M00500 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat SRD1_k127_2648702_3 296591.Bpro_3511 2.316e-28 120.0 COG0784@1|root,COG4251@1|root,COG0784@2|Bacteria,COG4251@2|Bacteria,1NC9X@1224|Proteobacteria 1224|Proteobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,PAS_4,PAS_7,Response_reg SRD1_k127_265282_1 330214.NIDE0478 4.149e-92 306.0 COG0588@1|root,COG0588@2|Bacteria,3J118@40117|Nitrospirae 40117|Nitrospirae G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate gpmA - 5.4.2.11 ko:K01834 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - His_Phos_1 SRD1_k127_265282_2 1132509.C447_11230 1.149e-15 91.0 COG3250@1|root,arCOG07337@2157|Archaea,2XUP8@28890|Euryarchaeota,23TIH@183963|Halobacteria 183963|Halobacteria G COG3250 Beta-galactosidase beta-glucuronidase - - 3.2.1.31 ko:K01195 ko00040,ko00531,ko00860,ko00944,ko00983,ko01100,ko01110,ko04142,map00040,map00531,map00860,map00944,map00983,map01100,map01110,map04142 M00014,M00076,M00077,M00078,M00129 R01478,R04979,R07818,R08127,R08260,R10830 RC00055,RC00171,RC00529,RC00530,RC00714,RC01251 ko00000,ko00001,ko00002,ko01000 - - - Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N SRD1_k127_265282_0 1121889.AUDM01000018_gene1227 8.291e-105 363.0 COG0366@1|root,COG0366@2|Bacteria,4NEVK@976|Bacteroidetes,1HYB7@117743|Flavobacteriia,2P04M@237|Flavobacterium 976|Bacteroidetes G Alpha amylase, catalytic domain - - - - - - - - - - - - Alpha-amylase,Alpha-amylase_C,Malt_amylase_C SRD1_k127_2672668_0 945713.IALB_3049 3.504e-67 237.0 COG3104@1|root,COG3104@2|Bacteria 2|Bacteria E oligopeptide transport - - - ko:K03305 - - - - ko00000 2.A.17 - - MFS_1,PTR2 SRD1_k127_2672668_1 1173027.Mic7113_5748 1.929e-52 196.0 2EJTI@1|root,33DI5@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - Methyltransf_21 SRD1_k127_2682539_1 1379698.RBG1_1C00001G1247 7.194e-51 192.0 COG3404@1|root,COG3643@1|root,COG3404@2|Bacteria,COG3643@2|Bacteria,2NNXZ@2323|unclassified Bacteria 2|Bacteria E Formiminotransferase-cyclodeaminase ftcD - 2.1.2.5,4.3.1.4 ko:K00603,ko:K01746,ko:K13990 ko00340,ko00670,ko01100,map00340,map00670,map01100 - R02287,R02302,R03189 RC00165,RC00221,RC00223,RC00688,RC00870 ko00000,ko00001,ko01000,ko03036,ko04147 - - - FTCD,FTCD_C,FTCD_N SRD1_k127_2682539_0 1089553.Tph_c20450 3.232e-125 419.0 COG1228@1|root,COG1228@2|Bacteria,1TP2J@1239|Firmicutes,24AGR@186801|Clostridia,42EXG@68295|Thermoanaerobacterales 186801|Clostridia F Belongs to the metallo-dependent hydrolases superfamily. HutI family hutI - 3.5.2.7 ko:K01468 ko00340,ko01100,map00340,map01100 M00045 R02288 RC00683 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1,Amidohydro_3 SRD1_k127_2683540_0 1519464.HY22_04375 1.022e-47 183.0 COG5448@1|root,COG5448@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - DUF2460 SRD1_k127_2683540_2 517418.Ctha_0085 9.837e-06 56.0 2BQJ0@1|root,32XXI@2|Bacteria,1FE6A@1090|Chlorobi 1090|Chlorobi S Domain of unknown function (DUF4412) - - - - - - - - - - - - DUF4412 SRD1_k127_2683540_1 945713.IALB_1078 1.21e-34 147.0 COG4447@1|root,COG4447@2|Bacteria 2|Bacteria S cellulose binding - - - - - - - - - - - - BNR,PSII_BNR SRD1_k127_2724653_2 1122605.KB893644_gene1499 1.756e-42 165.0 COG4225@1|root,COG4225@2|Bacteria,4NFWI@976|Bacteroidetes,1IP2G@117747|Sphingobacteriia 976|Bacteroidetes S PFAM Glycosyl Hydrolase Family 88 - - 3.2.1.172 ko:K15532 - - - - ko00000,ko01000 - GH105 - Glyco_hydro_88 SRD1_k127_2724653_0 518766.Rmar_2471 2.491e-125 424.0 COG2911@1|root,COG2911@2|Bacteria 2|Bacteria S protein secretion yeeJ - - ko:K20276 ko02024,map02024 - - - ko00000,ko00001 - - - Big_3_2,Big_3_3,HemolysinCabind,VWA_2 SRD1_k127_2724653_1 518766.Rmar_2472 3.067e-125 414.0 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,4NFAM@976|Bacteroidetes,1FJS1@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes P TonB-dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec SRD1_k127_2731578_2 697281.Mahau_0032 5.197e-54 201.0 COG0407@1|root,COG0407@2|Bacteria,1V5KX@1239|Firmicutes,24IAR@186801|Clostridia 186801|Clostridia H Uroporphyrinogen decarboxylase (URO-D) - - - - - - - - - - - - URO-D SRD1_k127_2731578_1 926550.CLDAP_21990 2.023e-61 225.0 COG0673@1|root,COG0673@2|Bacteria,2G5VF@200795|Chloroflexi 200795|Chloroflexi S PFAM oxidoreductase domain protein - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C SRD1_k127_2731578_0 1499967.BAYZ01000016_gene6546 2.438e-76 275.0 COG0383@1|root,COG0383@2|Bacteria,2NQ98@2323|unclassified Bacteria 2|Bacteria G Alpha mannosidase, middle domain mngB GO:0003674,GO:0003824,GO:0004553,GO:0004559,GO:0005975,GO:0005996,GO:0006013,GO:0006464,GO:0006517,GO:0006807,GO:0008150,GO:0008152,GO:0009100,GO:0009987,GO:0015923,GO:0016787,GO:0016798,GO:0019318,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0071704,GO:1901135,GO:1901564 2.3.1.204,3.2.1.170,3.2.1.24 ko:K01191,ko:K15524,ko:K16869 ko00511,map00511 - - - ko00000,ko00001,ko01000,ko04131 - GH38 iEcolC_1368.EcolC_2924,iSF_1195.SF0565,iSFxv_1172.SFxv_0623,iS_1188.S0578 Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C SRD1_k127_274502_0 945713.IALB_2005 2.849e-191 604.0 COG4799@1|root,COG4799@2|Bacteria 2|Bacteria I CoA carboxylase activity pccB - 2.1.3.15,6.4.1.3 ko:K01966 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00373,M00741 R01859 RC00097,RC00609 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans SRD1_k127_274502_2 330214.NIDE0581 0.0002075 48.0 COG2204@1|root,COG2204@2|Bacteria 2|Bacteria T phosphorelay signal transduction system lpxC - 3.5.1.108 ko:K02535 ko00540,ko01100,map00540,map01100 M00060 R04587 RC00166,RC00300 ko00000,ko00001,ko00002,ko01000,ko01005 - - - HisKA,LpxC,PAS_3,Response_reg SRD1_k127_2761680_0 1191523.MROS_1559 1.115e-123 414.0 COG1519@1|root,COG1519@2|Bacteria 2|Bacteria M Transferase waaA GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008176,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0036265,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0106004,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234 2.1.1.33,2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 ko:K02527,ko:K03439 ko00540,ko01100,map00540,map01100 M00060,M00080 R04658,R05074,R09763 RC00009,RC00077,RC00247 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005,ko03016 - GT30 - Glycos_transf_N SRD1_k127_2761680_2 880073.Calab_0968 1.076e-65 237.0 COG0859@1|root,COG0859@2|Bacteria,2NP5P@2323|unclassified Bacteria 2|Bacteria M Glycosyl transferase, family 9 - - - ko:K02843 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT9 - Glyco_transf_9 SRD1_k127_2761680_1 518766.Rmar_2682 1.448e-121 394.0 COG1239@1|root,COG1239@2|Bacteria,4NF1J@976|Bacteroidetes,1FIU1@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes H magnesium chelatase chlI - 6.6.1.1 ko:K03405 ko00860,ko01100,ko01110,map00860,map01100,map01110 - R03877 RC01012 ko00000,ko00001,ko01000 - - - AAA_5,Sigma54_activat SRD1_k127_2782971_3 315730.BcerKBAB4_4418 1.698e-18 87.0 COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,4HB1B@91061|Bacilli,1ZC0T@1386|Bacillus 91061|Bacilli T Signal transduction histidine kinase phoR - 2.7.13.3 ko:K07636 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_9,sCache_like SRD1_k127_2782971_1 1267533.KB906733_gene2988 3.601e-68 239.0 COG0745@1|root,COG0745@2|Bacteria,3Y4D1@57723|Acidobacteria 57723|Acidobacteria T Transcriptional regulatory protein, C terminal - - - - - - - - - - - - Response_reg,Trans_reg_C SRD1_k127_2782971_4 1217718.ALOU01000001_gene4556 4.48e-10 71.0 COG4775@1|root,COG4775@2|Bacteria,1QUE3@1224|Proteobacteria 1224|Proteobacteria M Surface antigen - - - - - - - - - - - - Bac_surface_Ag SRD1_k127_2782971_0 290397.Adeh_3107 4.849e-69 255.0 COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria 1224|Proteobacteria F Belongs to the 5'-nucleotidase family - - 3.1.3.5,3.6.1.45 ko:K11751 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - - 5_nucleotid_C,Metallophos SRD1_k127_2782971_5 1380394.JADL01000002_gene1386 0.0006789 51.0 COG5662@1|root,COG5662@2|Bacteria,1MV95@1224|Proteobacteria,2TVRG@28211|Alphaproteobacteria,2JX7C@204441|Rhodospirillales 204441|Rhodospirillales K Putative zinc-finger - - - - - - - - - - - - zf-HC2 SRD1_k127_2782971_2 1313301.AUGC01000004_gene2214 3.252e-26 113.0 COG1595@1|root,COG1595@2|Bacteria,4NX8R@976|Bacteroidetes 976|Bacteroidetes K Sigma-70 region 2 - - - - - - - - - - - - Sigma70_ECF,Sigma70_r2 SRD1_k127_278353_1 518766.Rmar_1577 2.574e-25 116.0 COG2834@1|root,COG2834@2|Bacteria,4PESZ@976|Bacteroidetes,1FJJM@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes M outer membrane lipoprotein carrier protein LolA - - - ko:K03634 - - - - ko00000 - - - LolA SRD1_k127_278353_0 1191523.MROS_1729 4.773e-217 700.0 COG1674@1|root,COG1674@2|Bacteria 2|Bacteria D ftsk spoiiie ftsK - - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma SRD1_k127_278353_2 1379698.RBG1_1C00001G0649 2.687e-23 104.0 COG2045@1|root,COG2045@2|Bacteria,2NPF1@2323|unclassified Bacteria 2|Bacteria H Belongs to the ComB family comB GO:0003674,GO:0003824,GO:0016829,GO:0016830,GO:0016831,GO:0050545 3.1.3.71 ko:K05979 ko00680,ko01120,map00680,map01120 M00358 R05789 RC00428 ko00000,ko00001,ko00002,ko01000 - - - 2-ph_phosp SRD1_k127_2795022_0 929556.Solca_1777 3.471e-287 902.0 COG0726@1|root,COG1215@1|root,COG3858@1|root,COG0726@2|Bacteria,COG1215@2|Bacteria,COG3858@2|Bacteria,4NH18@976|Bacteroidetes,1IQRP@117747|Sphingobacteriia 976|Bacteroidetes M glycosyl transferase family 2 - - 3.5.1.104 ko:K22278 - - - - ko00000,ko01000 - - - Glyco_hydro_18,Glyco_tranf_2_3,Glycos_transf_2,Polysacc_deac_1 SRD1_k127_2800419_2 1232410.KI421421_gene3392 1.097e-33 148.0 COG0438@1|root,COG0438@2|Bacteria,1MU9C@1224|Proteobacteria,42WRR@68525|delta/epsilon subdivisions,2WRPY@28221|Deltaproteobacteria,43VHR@69541|Desulfuromonadales 28221|Deltaproteobacteria M Glycosyltransferase Family 4 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 SRD1_k127_2800419_0 1185876.BN8_02606 1.204e-113 375.0 COG0451@1|root,COG0451@2|Bacteria,4NEKA@976|Bacteroidetes,47JU9@768503|Cytophagia 976|Bacteroidetes M PFAM NAD dependent epimerase dehydratase family - - 5.1.3.6 ko:K08679 ko00520,ko01100,map00520,map01100 - R01385 RC00289 ko00000,ko00001,ko01000 - - - Epimerase,GDP_Man_Dehyd SRD1_k127_2800419_1 1124780.ANNU01000062_gene575 6.308e-47 183.0 COG0726@1|root,COG0726@2|Bacteria 2|Bacteria G polysaccharide deacetylase - - - - - - - - - - - - Polysacc_deac_1 SRD1_k127_2800419_3 419610.Mext_3569 7.395e-22 108.0 COG0438@1|root,COG0438@2|Bacteria,1Q1CU@1224|Proteobacteria,2UW3F@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Glycosyl transferase 4-like domain - - - - - - - - - - - - Glyco_trans_1_4,Glyco_transf_4 SRD1_k127_2807581_2 880073.Calab_1558 3.419e-34 141.0 COG1629@1|root,COG4771@2|Bacteria,2NP6Z@2323|unclassified Bacteria 2|Bacteria P COGs COG1629 Outer membrane receptor protein mostly Fe transport - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_dep_Rec SRD1_k127_2807581_4 880073.Calab_0922 1.369e-25 118.0 COG2067@1|root,COG2067@2|Bacteria,2NRA4@2323|unclassified Bacteria 2|Bacteria I PFAM Uncharacterised protein family (UPF0164) - - - - - - - - - - - - UPF0164 SRD1_k127_2807581_0 945713.IALB_1004 1.59e-135 452.0 COG2355@1|root,COG2355@2|Bacteria 2|Bacteria E Zn-dependent dipeptidase, microsomal dipeptidase - - 3.4.13.19 ko:K01273 - - - - ko00000,ko00537,ko01000,ko01002,ko04147 - - - Peptidase_M19 SRD1_k127_2807581_5 290397.Adeh_0041 1.533e-14 76.0 COG0280@1|root,COG0280@2|Bacteria,1QTXP@1224|Proteobacteria,42RGR@68525|delta/epsilon subdivisions,2WNWC@28221|Deltaproteobacteria 28221|Deltaproteobacteria C PFAM Phosphate acetyl butaryl transferase - - 2.3.1.19 ko:K00634 ko00650,ko01100,map00650,map01100 - R01174 RC00004,RC02816 ko00000,ko00001,ko01000 - - - PTA_PTB SRD1_k127_2839527_1 1123277.KB893174_gene6071 2.276e-43 162.0 COG0697@1|root,COG0697@2|Bacteria,4NHXC@976|Bacteroidetes,47T35@768503|Cytophagia 976|Bacteroidetes EG EamA-like transporter family - - - - - - - - - - - - EamA SRD1_k127_2839527_0 1123248.KB893315_gene2966 1.148e-201 636.0 COG3345@1|root,COG3345@2|Bacteria,4NFSU@976|Bacteroidetes,1J0QP@117747|Sphingobacteriia 976|Bacteroidetes G Alpha galactosidase A - - 3.2.1.22 ko:K07407 ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603 - R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091 RC00049,RC00059,RC00451 ko00000,ko00001,ko01000 - - - He_PIG,He_PIG_assoc,Melibiase_2,Melibiase_2_C SRD1_k127_2839527_2 1408473.JHXO01000012_gene356 4.251e-30 122.0 COG4299@1|root,COG4299@2|Bacteria,4NGKU@976|Bacteroidetes,2FQUY@200643|Bacteroidia 976|Bacteroidetes S Domain of unknown function (DUF5009) - - - - - - - - - - - - DUF5009 SRD1_k127_28410_1 945713.IALB_0828 6.413e-41 154.0 COG1366@1|root,COG1366@2|Bacteria 2|Bacteria T antisigma factor binding btrV - - ko:K04749,ko:K06378 - - - - ko00000,ko03021 - - - STAS,STAS_2 SRD1_k127_28410_2 945713.IALB_0829 3.334e-38 149.0 COG2172@1|root,COG2172@2|Bacteria 2|Bacteria T sigma factor antagonist activity - - 2.7.11.1 ko:K04757 - - - - ko00000,ko01000,ko01001,ko03021 - - - HATPase_c_2 SRD1_k127_28410_0 945713.IALB_0830 4.564e-101 347.0 COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria 2|Bacteria T phosphoserine phosphatase activity rsbU - 3.1.3.3,4.6.1.1 ko:K01768,ko:K07315 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000,ko03021 - - - GAF,GAF_2,GAF_3,HATPase_c_2,SSF,SpoIIE SRD1_k127_2852571_3 1121875.KB907547_gene3471 2.341e-102 344.0 2C20F@1|root,32R9J@2|Bacteria,4P0SP@976|Bacteroidetes 976|Bacteroidetes S Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family - - - - - - - - - - - - Peptidase_C92 SRD1_k127_2852571_0 1123276.KB893313_gene3910 4.148e-225 707.0 COG1012@1|root,COG1012@2|Bacteria,4NEB7@976|Bacteroidetes,47MNC@768503|Cytophagia 976|Bacteroidetes C Aldehyde dehydrogenase family mmsA - 1.2.1.18,1.2.1.27 ko:K00140,ko:K22187 ko00040,ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00040,map00280,map00410,map00562,map00640,map01100,map01200 M00013 R00705,R00706,R00922,R00935,R11768 RC00004,RC00080,RC02723,RC02817 ko00000,ko00001,ko00002,ko01000 - - - Aldedh SRD1_k127_2852571_1 448385.sce4721 6.392e-224 704.0 COG1953@1|root,COG1953@2|Bacteria,1MV18@1224|Proteobacteria,42X2Z@68525|delta/epsilon subdivisions,2WTRX@28221|Deltaproteobacteria,2YTSH@29|Myxococcales 28221|Deltaproteobacteria FH Permease for cytosine/purines, uracil, thiamine, allantoin - - - ko:K03457 - - - - ko00000 2.A.39 - - Transp_cyt_pur SRD1_k127_2852571_2 234267.Acid_7659 2.153e-174 552.0 COG0044@1|root,COG0044@2|Bacteria,3Y48H@57723|Acidobacteria 57723|Acidobacteria F PFAM amidohydrolase - - 3.5.2.2 ko:K01464 ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100 M00046 R02269,R03055,R08227 RC00632,RC00680 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Amidohydro_1 SRD1_k127_2873670_0 1047013.AQSP01000089_gene1181 3.051e-49 192.0 COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria 2|Bacteria S cAMP biosynthetic process cyaJ - 4.6.1.1 ko:K01768,ko:K02483 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000,ko02022 - - - Guanylate_cyc,HTH_18,TPR_16,TPR_19,TPR_2,TPR_8 SRD1_k127_2895877_0 382464.ABSI01000010_gene3520 3.5e-17 94.0 COG1874@1|root,COG1874@2|Bacteria 2|Bacteria G beta-galactosidase activity - - 3.2.1.23 ko:K12308 ko00052,map00052 - R01105 RC00452 ko00000,ko00001,ko01000 - - - Glyco_hydro_42 SRD1_k127_2895877_1 637389.Acaty_c0263 2.903e-12 73.0 COG3637@1|root,COG3637@2|Bacteria,1Q082@1224|Proteobacteria,1T8ZP@1236|Gammaproteobacteria,2NDP3@225057|Acidithiobacillales 225057|Acidithiobacillales M Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - - - - - - - - - - - SRD1_k127_2910068_0 1297742.A176_06096 1.942e-74 261.0 COG0308@1|root,COG0308@2|Bacteria,1MUCI@1224|Proteobacteria,42KZI@68525|delta/epsilon subdivisions,2WJ2C@28221|Deltaproteobacteria 28221|Deltaproteobacteria E Peptidase M1 membrane alanine aminopeptidase pepN - 3.4.11.2 ko:K01256,ko:K08776 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - DUF3458,DUF3458_C,ERAP1_C,Peptidase_M1 SRD1_k127_2910068_2 1379698.RBG1_1C00001G0404 2.556e-17 93.0 2EAFJ@1|root,334IY@2|Bacteria,2NRZR@2323|unclassified Bacteria 2|Bacteria S Domain of unknown function (DUF1844) - - - - - - - - - - - - DUF1844 SRD1_k127_2910068_1 1235815.BAIX01000003_gene406 5.111e-65 233.0 COG0061@1|root,COG0061@2|Bacteria,4NFG5@976|Bacteroidetes,2FMTM@200643|Bacteroidia 976|Bacteroidetes H Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP nadK - 2.7.1.23 ko:K00858 ko00760,ko01100,map00760,map01100 - R00104 RC00002,RC00078 ko00000,ko00001,ko01000 - - - NAD_kinase SRD1_k127_2910068_3 1191523.MROS_2746 1.084e-16 87.0 COG2010@1|root,COG2010@2|Bacteria 2|Bacteria C Cytochrome c - - - - - - - - - - - - PSCyt1 SRD1_k127_2910068_4 1227453.C444_15418 3.895e-05 53.0 arCOG02879@1|root,arCOG02879@2157|Archaea,2Y2VU@28890|Euryarchaeota,23Z53@183963|Halobacteria 183963|Halobacteria S Protein of unknown function (DUF4013) - - - - - - - - - - - - DUF4013 SRD1_k127_29153_0 742725.HMPREF9450_01261 2.98e-62 224.0 COG2871@1|root,COG3894@1|root,COG2871@2|Bacteria,COG3894@2|Bacteria,4PAMG@976|Bacteroidetes,2FXAJ@200643|Bacteroidia 976|Bacteroidetes C Domain of unknown function (DUF4445) - - - - - - - - - - - - DUF4445,Fer2 SRD1_k127_29153_1 945713.IALB_0390 1.463e-61 229.0 COG0642@1|root,COG2205@2|Bacteria 945713.IALB_0390|- T PhoQ Sensor - - - - - - - - - - - - - SRD1_k127_2919301_2 234267.Acid_4378 4.863e-41 155.0 COG2322@1|root,COG2322@2|Bacteria,3Y5H4@57723|Acidobacteria 57723|Acidobacteria S Protein of unknown function (DUF420) - - - ko:K08976 - - - - ko00000 - - - DUF420 SRD1_k127_2919301_0 1089550.ATTH01000001_gene1599 5.642e-73 261.0 COG0109@1|root,COG0109@2|Bacteria,4NF5A@976|Bacteroidetes,1FIYT@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes H Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group ctaB - 2.5.1.141 ko:K02257 ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714 M00154 R07411 RC01786 ko00000,ko00001,ko00002,ko01000,ko01006,ko03029 - - - UbiA SRD1_k127_2919301_1 481448.Minf_1426 1.638e-57 213.0 COG1612@1|root,COG1612@2|Bacteria,46T3F@74201|Verrucomicrobia,37G83@326457|unclassified Verrucomicrobia 74201|Verrucomicrobia O Cytochrome oxidase assembly protein ctaA - - ko:K02259 ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714 M00154 R07412 RC00769 ko00000,ko00001,ko00002,ko03029 3.D.4.4 - - COX15-CtaA SRD1_k127_2919301_3 1121904.ARBP01000006_gene3967 1.336e-07 58.0 COG1622@1|root,COG1622@2|Bacteria,4NFNF@976|Bacteroidetes,47JF8@768503|Cytophagia 976|Bacteroidetes C Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) ctaC - 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - COX2,COX2_TM SRD1_k127_295451_0 243231.GSU3062 1.526e-49 181.0 COG1032@1|root,COG1032@2|Bacteria,1MU15@1224|Proteobacteria,42N12@68525|delta/epsilon subdivisions,2WK0X@28221|Deltaproteobacteria,43U0H@69541|Desulfuromonadales 28221|Deltaproteobacteria C SMART Elongator protein 3 MiaB NifB - - - - - - - - - - - - Radical_SAM SRD1_k127_295451_1 671143.DAMO_1603 1.255e-44 166.0 COG0432@1|root,COG0432@2|Bacteria 2|Bacteria S Uncharacterised protein family UPF0047 - - - - - - - - - - - - UPF0047 SRD1_k127_295451_2 1034347.CAHJ01000092_gene1611 1.521e-12 71.0 2AWWM@1|root,31NU5@2|Bacteria,1TZQ8@1239|Firmicutes,4II4F@91061|Bacilli,1ZJ4J@1386|Bacillus 91061|Bacilli - - - - - - - - - - - - - - - SRD1_k127_2963013_4 1191523.MROS_1876 5.809e-93 316.0 COG2870@1|root,COG2870@2|Bacteria 2|Bacteria H ADP-L-glycero-beta-D-manno-heptose biosynthetic process rfaE - 2.7.1.167,2.7.7.70 ko:K03272 ko00540,ko01100,map00540,map01100 M00064 R05644,R05646 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CTP_transf_like,PfkB SRD1_k127_2963013_6 290512.Paes_1516 2.703e-45 171.0 COG0703@1|root,COG0703@2|Bacteria,1FDXE@1090|Chlorobi 1090|Chlorobi F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate aroK - 2.7.1.71 ko:K00891 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - SKI SRD1_k127_2963013_7 1125863.JAFN01000001_gene328 2.64e-38 155.0 COG3897@1|root,COG3897@2|Bacteria,1MUWA@1224|Proteobacteria 1224|Proteobacteria S Methyltransferase - - - - - - - - - - - - Methyltransf_11,Methyltransf_16,PrmA SRD1_k127_2963013_9 945713.IALB_2342 9.182e-21 101.0 COG3047@1|root,COG3047@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - OMP_b-brl SRD1_k127_2963013_2 945713.IALB_2343 4.298e-146 488.0 COG0760@1|root,COG0760@2|Bacteria 2|Bacteria O peptidyl-prolyl cis-trans isomerase activity ppiD - 5.2.1.8 ko:K01802,ko:K03769,ko:K03770 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_2,Rotamase_3,SurA_N_2,SurA_N_3 SRD1_k127_2963013_1 340177.Cag_0026 1.212e-163 536.0 COG0342@1|root,COG0342@2|Bacteria,1FDI5@1090|Chlorobi 1090|Chlorobi U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD - - ko:K03072 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG SRD1_k127_2963013_5 945713.IALB_0834 2.568e-81 280.0 COG0341@1|root,COG0341@2|Bacteria 2|Bacteria U P-P-bond-hydrolysis-driven protein transmembrane transporter activity secF GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - ko:K03072,ko:K03074,ko:K12257 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG SRD1_k127_2963013_8 1121104.AQXH01000001_gene1809 2.704e-31 126.0 COG1366@1|root,COG1366@2|Bacteria,4NTNE@976|Bacteroidetes 976|Bacteroidetes T Belongs to the anti-sigma-factor antagonist family - - - ko:K04749 - - - - ko00000,ko03021 - - - STAS SRD1_k127_2963013_0 1191523.MROS_1853 2.339e-175 562.0 COG0104@1|root,COG0104@2|Bacteria 2|Bacteria F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP purA GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.4 ko:K01939 ko00230,ko00250,ko01100,map00230,map00250,map01100 M00049 R01135 RC00458,RC00459 ko00000,ko00001,ko00002,ko01000 - - - Adenylsucc_synt SRD1_k127_2963013_3 945713.IALB_0822 7.347e-109 365.0 COG4191@1|root,COG4191@2|Bacteria 2|Bacteria T Histidine kinase vicK - 2.1.1.80,2.7.13.3,3.1.1.61 ko:K07709,ko:K13924 ko02020,ko02030,map02020,map02030 M00499,M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - HATPase_c,HisKA SRD1_k127_2979924_0 880073.Calab_0032 1.446e-291 916.0 COG3408@1|root,COG3408@2|Bacteria,2NPYR@2323|unclassified Bacteria 2|Bacteria G Amylo-alpha-1,6-glucosidase - - - - - - - - - - - - DUF608,GDE_C,GDE_N_bis SRD1_k127_2987978_1 1095769.CAHF01000006_gene1856 3.585e-63 224.0 COG5637@1|root,COG5637@2|Bacteria,1RCEX@1224|Proteobacteria,2VQP4@28216|Betaproteobacteria,4771P@75682|Oxalobacteraceae 28216|Betaproteobacteria O Polyketide cyclase / dehydrase and lipid transport - - - - - - - - - - - - Polyketide_cyc SRD1_k127_2987978_0 1183438.GKIL_1012 2.26e-91 309.0 COG0265@1|root,COG0265@2|Bacteria,1G3YY@1117|Cyanobacteria 1117|Cyanobacteria O PFAM PDZ domain (Also known as DHR or GLGF) - - - - - - - - - - - - PDZ_2,Trypsin_2 SRD1_k127_2987978_2 1340493.JNIF01000003_gene1711 4.525e-58 215.0 COG0265@1|root,COG0265@2|Bacteria,3Y87N@57723|Acidobacteria 57723|Acidobacteria O Trypsin-like peptidase domain - - - - - - - - - - - - Trypsin_2 SRD1_k127_2987978_3 1183438.GKIL_1013 2.384e-06 55.0 COG2197@1|root,COG2197@2|Bacteria,1G712@1117|Cyanobacteria 1117|Cyanobacteria K Bacterial regulatory proteins, luxR family - - - - - - - - - - - - GerE,Response_reg SRD1_k127_2989099_0 1123368.AUIS01000006_gene665 9.186e-233 734.0 COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,1RNKN@1236|Gammaproteobacteria,2NCNU@225057|Acidithiobacillales 225057|Acidithiobacillales CP NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus - - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M,Proton_antipo_N SRD1_k127_2989099_4 1122951.ATUE01000005_gene1797 6.919e-28 118.0 COG0713@1|root,COG0713@2|Bacteria,1RH0S@1224|Proteobacteria,1S6FN@1236|Gammaproteobacteria,3NSRR@468|Moraxellaceae 1236|Gammaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoK GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016021,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0031224,GO:0031226,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204 1.6.5.3 ko:K00340 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q2 SRD1_k127_2989099_3 105559.Nwat_1909 2.749e-44 168.0 COG0839@1|root,COG0839@2|Bacteria,1MWJV@1224|Proteobacteria,1S65T@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the complex I subunit 6 family nuoJ GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016021,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0031224,GO:0031226,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204 1.6.5.3 ko:K00339 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - e_coli_core.b2280,iAF1260.b2280,iAPECO1_1312.APECO1_4285,iB21_1397.B21_02165,iBWG_1329.BWG_2054,iE2348C_1286.E2348C_2420,iEC042_1314.EC042_2521,iEC55989_1330.EC55989_2524,iECABU_c1320.ECABU_c26120,iECBD_1354.ECBD_1381,iECB_1328.ECB_02205,iECDH10B_1368.ECDH10B_2442,iECDH1ME8569_1439.ECDH1ME8569_2217,iECD_1391.ECD_02205,iECED1_1282.ECED1_2744,iECH74115_1262.ECH74115_3419,iECIAI1_1343.ECIAI1_2354,iECIAI39_1322.ECIAI39_2427,iECNA114_1301.ECNA114_2370,iECO103_1326.ECO103_2744,iECO111_1330.ECO111_3028,iECO26_1355.ECO26_3268,iECOK1_1307.ECOK1_2513,iECP_1309.ECP_2319,iECS88_1305.ECS88_2427,iECSE_1348.ECSE_2537,iECSF_1327.ECSF_2157,iECSP_1301.ECSP_3154,iECUMN_1333.ECUMN_2619,iECW_1372.ECW_m2468,iECs_1301.ECs3164,iEKO11_1354.EKO11_1487,iETEC_1333.ETEC_2415,iEcDH1_1363.EcDH1_1377,iEcE24377_1341.EcE24377A_2573,iEcHS_1320.EcHS_A2429,iEcSMS35_1347.EcSMS35_2434,iEcolC_1368.EcolC_1372,iJO1366.b2280,iJR904.b2280,iLF82_1304.LF82_1547,iNRG857_1313.NRG857_11545,iSBO_1134.SBO_2313,iSDY_1059.SDY_2476,iSFV_1184.SFV_2347,iSF_1195.SF2356,iSFxv_1172.SFxv_2600,iSSON_1240.SSON_2337,iS_1188.S2491,iSbBS512_1146.SbBS512_E2656,iUMN146_1321.UM146_05415,iUMNK88_1353.UMNK88_2830,iUTI89_1310.UTI89_C2560,iWFL_1372.ECW_m2468,iY75_1357.Y75_RS11955,iZ_1308.Z3539,ic_1306.c2821 Oxidored_q3 SRD1_k127_2989099_2 1267535.KB906767_gene62 3.676e-88 294.0 COG1143@1|root,COG1143@2|Bacteria 2|Bacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoI GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0030964,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204 1.6.5.3 ko:K00338 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - e_coli_core.b2281,iAF1260.b2281,iAPECO1_1312.APECO1_4284,iB21_1397.B21_02166,iBWG_1329.BWG_2055,iE2348C_1286.E2348C_2421,iEC042_1314.EC042_2522,iEC55989_1330.EC55989_2525,iECABU_c1320.ECABU_c26130,iECBD_1354.ECBD_1380,iECB_1328.ECB_02206,iECDH10B_1368.ECDH10B_2443,iECDH1ME8569_1439.ECDH1ME8569_2218,iECD_1391.ECD_02206,iECED1_1282.ECED1_2745,iECH74115_1262.ECH74115_3420,iECIAI1_1343.ECIAI1_2355,iECIAI39_1322.ECIAI39_2428,iECNA114_1301.ECNA114_2371,iECO103_1326.ECO103_2745,iECO111_1330.ECO111_3029,iECO26_1355.ECO26_3269,iECOK1_1307.ECOK1_2514,iECP_1309.ECP_2320,iECS88_1305.ECS88_2428,iECSE_1348.ECSE_2538,iECSF_1327.ECSF_2158,iECSP_1301.ECSP_3155,iECUMN_1333.ECUMN_2620,iECW_1372.ECW_m2469,iECs_1301.ECs3165,iEKO11_1354.EKO11_1486,iETEC_1333.ETEC_2416,iEcDH1_1363.EcDH1_1376,iEcE24377_1341.EcE24377A_2574,iEcHS_1320.EcHS_A2430,iEcSMS35_1347.EcSMS35_2435,iEcolC_1368.EcolC_1371,iG2583_1286.G2583_2818,iJO1366.b2281,iJR904.b2281,iLF82_1304.LF82_1546,iNRG857_1313.NRG857_11550,iPC815.YPO2548,iSBO_1134.SBO_2314,iSFV_1184.SFV_2348,iSF_1195.SF2357,iSFxv_1172.SFxv_2601,iS_1188.S2492,iSbBS512_1146.SbBS512_E2657,iUMN146_1321.UM146_05410,iUMNK88_1353.UMNK88_2831,iUTI89_1310.UTI89_C2561,iWFL_1372.ECW_m2469,iY75_1357.Y75_RS11960,iZ_1308.Z3540,ic_1306.c2822 Fer4 SRD1_k127_2989099_1 1267535.KB906767_gene61 6.113e-149 475.0 COG1005@1|root,COG1005@2|Bacteria,3Y3VS@57723|Acidobacteria,2JHQZ@204432|Acidobacteriia 204432|Acidobacteriia C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone - - - - - - - - - - - - NADHdh SRD1_k127_3008690_0 926550.CLDAP_07830 1.239e-39 156.0 COG4447@1|root,COG4447@2|Bacteria,2G66V@200795|Chloroflexi 200795|Chloroflexi G glycosyl hydrolase, BNR repeat-containing protein - - - - - - - - - - - - Sortilin-Vps10 SRD1_k127_3008690_1 382464.ABSI01000010_gene3492 2.838e-39 158.0 2DBYV@1|root,2ZBXC@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - SRD1_k127_3042627_5 880073.Calab_1564 6.076e-45 183.0 2DBN4@1|root,2ZA1T@2|Bacteria 2|Bacteria S fibronectin type III domain protein - - - - - - - - - - - - - SRD1_k127_3042627_4 945713.IALB_1001 1.369e-55 207.0 COG2067@1|root,COG2067@2|Bacteria 2|Bacteria I long-chain fatty acid transporting porin activity - - - - - - - - - - - - - SRD1_k127_3042627_2 525904.Tter_2571 3.822e-63 231.0 COG0454@1|root,COG0456@2|Bacteria,2NQYF@2323|unclassified Bacteria 2|Bacteria K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_7 SRD1_k127_3042627_0 504472.Slin_5410 2.069e-95 325.0 COG4299@1|root,COG4299@2|Bacteria,4NDZF@976|Bacteroidetes,47JVV@768503|Cytophagia 976|Bacteroidetes S Protein of unknown function (DUF1624) - - - - - - - - - - - - DUF1624,DUF5009 SRD1_k127_3042627_1 1267535.KB906767_gene3949 4.304e-73 261.0 COG2120@1|root,COG2120@2|Bacteria 2|Bacteria S N-acetylglucosaminylinositol deacetylase activity - - - - - - - - - - - - PIG-L SRD1_k127_3042627_3 1462527.CCDM010000001_gene2736 4.714e-62 225.0 COG0454@1|root,COG0456@2|Bacteria,1TRSU@1239|Firmicutes,4HDDT@91061|Bacilli 91061|Bacilli K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_7 SRD1_k127_3042627_6 309803.CTN_0403 6.314e-22 106.0 COG3534@1|root,COG3534@2|Bacteria 2|Bacteria G alpha-L-arabinofuranosidase - - 3.2.1.55 ko:K01209 ko00520,map00520 - R01762 - ko00000,ko00001,ko01000 - GH51 - Alpha-L-AF_C,Glyco_hydro_79n SRD1_k127_3042881_2 1232410.KI421421_gene3583 7.214e-38 150.0 COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,1MUXD@1224|Proteobacteria,42M0M@68525|delta/epsilon subdivisions,2WJ4Y@28221|Deltaproteobacteria,43S6C@69541|Desulfuromonadales 28221|Deltaproteobacteria M SIS domain kdsD - 5.3.1.13 ko:K06041 ko00540,ko01100,map00540,map01100 M00063 R01530 RC00541 ko00000,ko00001,ko00002,ko01000,ko01005 - - iAF987.Gmet_1278 CBS,SIS SRD1_k127_3042881_1 1122947.FR7_1574 3.85e-44 167.0 COG1778@1|root,COG1778@2|Bacteria,1V5JJ@1239|Firmicutes,4H4ID@909932|Negativicutes 909932|Negativicutes S 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family kdsC - 3.1.3.45 ko:K03270 ko00540,ko01100,map00540,map01100 M00063 R03350 RC00017 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hydrolase_3 SRD1_k127_3042881_0 1191523.MROS_0384 1.237e-100 337.0 COG2877@1|root,COG2877@2|Bacteria 2|Bacteria M 3-deoxy-8-phosphooctulonate synthase activity kdsA GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005996,GO:0006082,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008676,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016043,GO:0016051,GO:0016053,GO:0016740,GO:0016765,GO:0019294,GO:0019752,GO:0022607,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0046394,GO:0046400,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.5.1.55 ko:K01627 ko00540,ko01100,map00540,map01100 M00063 R03254 RC00435 ko00000,ko00001,ko00002,ko01000,ko01005 - - - DAHP_synth_1 SRD1_k127_3042881_3 1191523.MROS_1536 3.975e-07 53.0 COG1649@1|root,COG1649@2|Bacteria 2|Bacteria F PFAM Uncharacterised BCR, COG1649 - - 3.2.1.11,3.2.1.18,3.2.1.35,4.2.2.23 ko:K01186,ko:K01197,ko:K05988,ko:K11931,ko:K18197 ko00500,ko00511,ko00531,ko00600,ko01100,ko02026,ko04142,map00500,map00511,map00531,map00600,map01100,map02026,map04142 M00076,M00077 R04018,R07824,R07825,R10905,R11309 RC00028,RC00077 ko00000,ko00001,ko00002,ko00536,ko00537,ko01000,ko02042 - GH33,GH66,PL11 - DUF1349,GHL10,Glyco_hydro_20b,Laminin_G_3,NAGidase,fn3 SRD1_k127_30451_7 880073.Calab_1112 1.17e-28 119.0 COG1132@1|root,COG1132@2|Bacteria,2NNN4@2323|unclassified Bacteria 2|Bacteria V ABC transporter transmembrane region mdlA - - ko:K06147,ko:K18889 ko02010,map02010 M00707 - - ko00000,ko00001,ko00002,ko02000 3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran SRD1_k127_30451_0 1089550.ATTH01000001_gene588 1.75e-155 502.0 COG0172@1|root,COG0172@2|Bacteria,4NED6@976|Bacteroidetes,1FIKA@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) serS - 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Seryl_tRNA_N,tRNA-synt_2b SRD1_k127_30451_2 517418.Ctha_2695 7.89e-94 320.0 COG1091@1|root,COG1091@2|Bacteria,1FD6G@1090|Chlorobi 1090|Chlorobi C Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose - - 1.1.1.133 ko:K00067 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R02777 RC00182 ko00000,ko00001,ko00002,ko01000 - - - RmlD_sub_bind SRD1_k127_30451_1 518766.Rmar_1660 2.725e-102 340.0 COG2171@1|root,COG2171@2|Bacteria,4NEWD@976|Bacteroidetes,1FJ1Z@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes E Tetrahydrodipicolinate N-succinyltransferase N-terminal dapD - 2.3.1.117 ko:K00674 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R04365 RC00004,RC01136 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,Hexapep_2,THDPS_N_2 SRD1_k127_30451_3 518766.Rmar_1658 6.841e-91 308.0 COG0329@1|root,COG0329@2|Bacteria,4NFP9@976|Bacteroidetes,1FIQT@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) dapA - 3.5.4.22,4.3.3.7 ko:K01714,ko:K21062 ko00261,ko00300,ko00330,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map00330,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R02280,R10147 RC00679,RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 - - - DHDPS SRD1_k127_30451_5 760011.Spico_0780 3.883e-63 226.0 COG0289@1|root,COG0289@2|Bacteria,2J647@203691|Spirochaetes 203691|Spirochaetes E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate dapB - 1.17.1.8 ko:K00215 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R04198,R04199 RC00478 ko00000,ko00001,ko00002,ko01000 - - - DapB_C,DapB_N SRD1_k127_30451_8 1191523.MROS_0375 1.239e-10 72.0 COG0524@1|root,COG0524@2|Bacteria 2|Bacteria G Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway rbsK - 2.7.1.15,2.7.1.184,2.7.1.4 ko:K00847,ko:K00852,ko:K18478 ko00030,ko00051,ko00500,ko00520,ko01100,map00030,map00051,map00500,map00520,map01100 - R00760,R00867,R01051,R02750,R03920,R10970 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PfkB SRD1_k127_30451_6 1304885.AUEY01000014_gene3336 5.55e-45 168.0 COG0041@1|root,COG0663@1|root,COG0041@2|Bacteria,COG0663@2|Bacteria,1RCWJ@1224|Proteobacteria,42QTK@68525|delta/epsilon subdivisions,2WNXM@28221|Deltaproteobacteria,2MPUJ@213118|Desulfobacterales 28221|Deltaproteobacteria F AIR carboxylase purE - 5.4.99.18 ko:K01588 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07405 RC01947 ko00000,ko00001,ko00002,ko01000 - - - AIRC SRD1_k127_30451_4 331678.Cphamn1_0475 1.006e-69 248.0 COG0106@1|root,COG0106@2|Bacteria,1FDFF@1090|Chlorobi 1090|Chlorobi F 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase hisA - 5.3.1.16 ko:K01814 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04640 RC00945 ko00000,ko00001,ko00002,ko01000 - - - His_biosynth SRD1_k127_30451_9 1006004.GBAG_0137 1.422e-07 54.0 COG1974@1|root,COG1974@2|Bacteria,1MW80@1224|Proteobacteria,1RMXF@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair lexA GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006282,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0009991,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031668,GO:0032774,GO:0032991,GO:0032993,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0046483,GO:0048519,GO:0048523,GO:0048583,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0065007,GO:0071496,GO:0071704,GO:0080090,GO:0080134,GO:0080135,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001020,GO:2001141 3.4.21.88 ko:K01356 - M00729 - - ko00000,ko00002,ko01000,ko01002,ko03400 - - - LexA_DNA_bind,Peptidase_S24 SRD1_k127_3048889_1 880073.Calab_0292 7.714e-104 352.0 COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,2NNNP@2323|unclassified Bacteria 2|Bacteria D CobQ CobB MinD ParA nucleotide binding domain - - - ko:K16554,ko:K16692 ko05111,map05111 - - - ko00000,ko00001,ko01000,ko01001,ko02000 8.A.3.1 - - AAA_31,CbiA,GNVR,ParA,Wzz SRD1_k127_3048889_3 880073.Calab_0291 1.325e-25 112.0 COG1596@1|root,COG1596@2|Bacteria 2|Bacteria M polysaccharide export wza - - ko:K01991 ko02026,map02026 - - - ko00000,ko00001,ko02000 1.B.18 - - Poly_export,SLBB SRD1_k127_3048889_4 118161.KB235922_gene4971 1.015e-13 76.0 COG1682@1|root,COG1682@2|Bacteria,1G23R@1117|Cyanobacteria,3VI47@52604|Pleurocapsales 1117|Cyanobacteria U COGs COG1682 ABC-type polysaccharide polyol phosphate export systems permease component - - - ko:K09690 ko02010,map02010 M00250 - - ko00000,ko00001,ko00002,ko02000 3.A.1.103 - - ABC2_membrane SRD1_k127_3048889_2 1173022.Cri9333_2785 4.971e-92 307.0 COG1682@1|root,COG1682@2|Bacteria,1G23R@1117|Cyanobacteria,1H8WK@1150|Oscillatoriales 1117|Cyanobacteria GM COG1682 ABC-type polysaccharide polyol phosphate export systems, permease component - - - ko:K09690 ko02010,map02010 M00250 - - ko00000,ko00001,ko00002,ko02000 3.A.1.103 - - ABC2_membrane SRD1_k127_3048889_0 118168.MC7420_2165 6.032e-113 368.0 COG1134@1|root,COG1134@2|Bacteria,1G28R@1117|Cyanobacteria,1H8CS@1150|Oscillatoriales 1117|Cyanobacteria GM ABC-type polysaccharide polyol phosphate transport system ATPase component - - - ko:K09691 ko02010,map02010 M00250 - - ko00000,ko00001,ko00002,ko02000 3.A.1.103 - - ABC_tran,Wzt_C SRD1_k127_3053097_0 552811.Dehly_0726 1.388e-236 747.0 COG3259@1|root,COG3259@2|Bacteria,2G68W@200795|Chloroflexi,34CQT@301297|Dehalococcoidia 301297|Dehalococcoidia C hydrogenase large subunit - - 1.8.98.5 ko:K14126 ko00680,map00680 - R00019,R11943 RC00011 ko00000,ko00001,ko01000 - - - NiFeSe_Hases SRD1_k127_3053097_1 552811.Dehly_0727 7.063e-130 423.0 COG1941@1|root,COG1941@2|Bacteria,2G6MH@200795|Chloroflexi,34D3J@301297|Dehalococcoidia 301297|Dehalococcoidia C NADH ubiquinone oxidoreductase, 20 Kd subunit - - 1.8.98.5 ko:K14128 ko00680,map00680 - R00019,R11943 RC00011 ko00000,ko00001,ko01000 - - - Oxidored_q6 SRD1_k127_3053097_3 552811.Dehly_0729 1.319e-66 230.0 COG1908@1|root,COG1908@2|Bacteria 2|Bacteria C Methyl-viologen-reducing hydrogenase, delta subunit - - 1.8.98.5,1.8.98.6 ko:K14127 ko00680,map00680 - R00019,R11943,R11944 RC00011 ko00000,ko00001,ko01000 - - - FlpD SRD1_k127_3053097_2 552811.Dehly_0730 1.405e-120 400.0 COG1148@1|root,COG1148@2|Bacteria 2|Bacteria C 4fe-4S ferredoxin, iron-sulfur binding domain protein - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_20,Fer4_7,Pyr_redox_2 SRD1_k127_3069558_2 1123277.KB893206_gene3373 1.061e-08 59.0 COG3250@1|root,COG3250@2|Bacteria,4NEDP@976|Bacteroidetes,47JV2@768503|Cytophagia 976|Bacteroidetes G Belongs to the glycosyl hydrolase 2 family - - 3.1.1.53 ko:K05970 - - - - ko00000,ko01000 - - - Glyco_hydro_2_N,SASA SRD1_k127_3069558_0 1185876.BN8_04115 0.0 1237.0 2DB7A@1|root,2Z7KK@2|Bacteria,4NGC2@976|Bacteroidetes,47KVX@768503|Cytophagia 976|Bacteroidetes S Glycosyl hydrolase family 115 - - - - - - - - - - - - Glyco_hydro_115,Glyco_hydro_67N SRD1_k127_3069558_1 926569.ANT_28570 2.093e-134 476.0 COG3405@1|root,COG3405@2|Bacteria 2|Bacteria G Belongs to the glycosyl hydrolase 8 (cellulase D) family - - 3.2.1.156 ko:K15531 - - - - ko00000,ko01000 - GH8 - CBM_2,Dockerin_1,Glyco_hydro_8,Polysacc_deac_1 SRD1_k127_3071006_0 1121920.AUAU01000004_gene857 1.073e-147 476.0 COG1804@1|root,COG1804@2|Bacteria,3Y4ZM@57723|Acidobacteria 57723|Acidobacteria C CoA-transferase family III - - - - - - - - - - - - CoA_transf_3 SRD1_k127_3071006_1 1121920.AUAU01000004_gene858 6.58e-92 310.0 COG0119@1|root,COG0119@2|Bacteria,3Y2NJ@57723|Acidobacteria 57723|Acidobacteria E HMGL-like - - 4.1.3.4 ko:K01640 ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146 M00036,M00088 R01360,R08090 RC00502,RC00503,RC01118,RC01946 ko00000,ko00001,ko00002,ko01000 - - - HMGL-like SRD1_k127_3076862_5 657309.BXY_19340 4.893e-32 133.0 COG1040@1|root,COG1040@2|Bacteria,4NNI1@976|Bacteroidetes,2FP14@200643|Bacteroidia,4AN3K@815|Bacteroidaceae 976|Bacteroidetes S ComF family comF - 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 - - - Pribosyltran SRD1_k127_3076862_0 1191523.MROS_0907 3.651e-292 910.0 COG0556@1|root,COG0556@2|Bacteria 2|Bacteria L nucleotide-excision repair uvrB GO:0002682,GO:0002684,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006950,GO:0008150,GO:0009314,GO:0009380,GO:0009605,GO:0009607,GO:0009628,GO:0016020,GO:0032991,GO:0035821,GO:0042802,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0044424,GO:0044464,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051409,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052564,GO:0052572,GO:0065007,GO:0071944,GO:0075136,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB SRD1_k127_3076862_2 1121920.AUAU01000007_gene506 4.021e-194 615.0 COG0477@1|root,COG2814@2|Bacteria,3Y6YQ@57723|Acidobacteria 57723|Acidobacteria EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 SRD1_k127_3076862_3 443144.GM21_0857 9.7e-175 566.0 COG2195@1|root,COG2195@2|Bacteria,1MUWK@1224|Proteobacteria,42PS0@68525|delta/epsilon subdivisions,2WJU3@28221|Deltaproteobacteria 28221|Deltaproteobacteria E TIGRFAM aminoacyl-histidine dipeptidase - - - ko:K01270 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - M20_dimer,Peptidase_M20,Peptidase_M28 SRD1_k127_3076862_1 204669.Acid345_4203 3.066e-230 737.0 COG1297@1|root,COG1297@2|Bacteria,3Y2UT@57723|Acidobacteria,2JHIU@204432|Acidobacteriia 204432|Acidobacteriia S Oligopeptide transporter OPT - - - - - - - - - - - - OPT SRD1_k127_3076862_4 869213.JCM21142_104287 2.129e-35 137.0 COG0506@1|root,COG0506@2|Bacteria,4NKZB@976|Bacteroidetes,47TEU@768503|Cytophagia 976|Bacteroidetes E Proline dehydrogenase - - - ko:K00318 ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130 - R10507 RC00083 ko00000,ko00001,ko01000 - - - Pro_dh SRD1_k127_3086694_2 1519464.HY22_00495 1.751e-41 177.0 COG2982@1|root,COG2982@2|Bacteria,1FFR4@1090|Chlorobi 1090|Chlorobi M TamB, inner membrane protein subunit of TAM complex - - - - - - - - - - - - TamB SRD1_k127_3086694_0 517418.Ctha_2627 7.628e-162 537.0 COG0557@1|root,COG0557@2|Bacteria,1FDF5@1090|Chlorobi 1090|Chlorobi J 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs rnr - - ko:K12573 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03016,ko03019 - - - OB_RNB,RNB,S1 SRD1_k127_3086694_3 945713.IALB_1581 1.776e-37 145.0 COG0789@1|root,COG0789@2|Bacteria 2|Bacteria K bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding ycgE - - ko:K19591,ko:K22491 - M00769 - - ko00000,ko00002,ko01504,ko03000 - - - MerR_1 SRD1_k127_3086694_1 1009370.ALO_01789 1.891e-65 227.0 COG1814@1|root,COG1814@2|Bacteria,1UQWP@1239|Firmicutes,4H8S9@909932|Negativicutes 909932|Negativicutes S VIT family - - - - - - - - - - - - VIT1 SRD1_k127_3096445_12 1235457.C404_05730 3.124e-12 74.0 COG5298@1|root,COG5298@2|Bacteria,1MYMJ@1224|Proteobacteria,2VPZF@28216|Betaproteobacteria,1K5UN@119060|Burkholderiaceae 28216|Betaproteobacteria S Uncharacterized protein conserved in bacteria (DUF2334) - - - - - - - - - - - - DUF2334 SRD1_k127_3096445_7 518766.Rmar_1871 7.056e-79 274.0 COG1619@1|root,COG1619@2|Bacteria,4NF5Q@976|Bacteroidetes,1FJBX@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes V LD-carboxypeptidase ldcA - 3.4.17.13 ko:K01297 - - - - ko00000,ko01000,ko01002,ko01011 - - - Peptidase_S66 SRD1_k127_3096445_8 518766.Rmar_1872 8.288e-62 218.0 COG0299@1|root,COG0299@2|Bacteria,4NNZP@976|Bacteroidetes,1FITI@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate purN - 2.1.2.2 ko:K11175 ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130 M00048 R04325,R04326 RC00026,RC00197,RC01128 ko00000,ko00001,ko00002,ko01000 - - - Formyl_trans_N SRD1_k127_3096445_4 517417.Cpar_1716 2.317e-171 552.0 COG0138@1|root,COG0138@2|Bacteria,1FDAA@1090|Chlorobi 1090|Chlorobi F Bifunctional purine biosynthesis protein PurH purH - 2.1.2.3,3.5.4.10 ko:K00602 ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 M00048 R01127,R04560 RC00026,RC00263,RC00456 ko00000,ko00001,ko00002,ko01000,ko04147 - - - AICARFT_IMPCHas,MGS SRD1_k127_3096445_3 1191523.MROS_2820 2.479e-175 554.0 COG1077@1|root,COG1077@2|Bacteria 2|Bacteria D Cell shape determining protein MreB Mrl mreB - - ko:K03569 - - - - ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 - - MreB_Mbl SRD1_k127_3096445_9 215803.DB30_6727 3.942e-33 139.0 COG1792@1|root,COG1792@2|Bacteria,1N8ZS@1224|Proteobacteria,42S9I@68525|delta/epsilon subdivisions,2WNTW@28221|Deltaproteobacteria,2YVI1@29|Myxococcales 28221|Deltaproteobacteria M Involved in formation and maintenance of cell shape mreC - - ko:K03570 - - - - ko00000,ko03036 9.B.157.1 - - MreC SRD1_k127_3096445_11 945713.IALB_1850 5.86e-15 87.0 2DTQV@1|root,33MB6@2|Bacteria 2|Bacteria S rod shape-determining protein MreD - - - ko:K03571 - - - - ko00000,ko03036 9.B.157.1 - - MreD SRD1_k127_3096445_2 517418.Ctha_2424 3.388e-178 580.0 COG0768@1|root,COG0768@2|Bacteria,1FD7D@1090|Chlorobi 1090|Chlorobi M PFAM penicillin-binding protein transpeptidase - - 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - - PBP_dimer,Transpeptidase SRD1_k127_3096445_5 945713.IALB_1848 8.647e-100 340.0 COG0772@1|root,COG0772@2|Bacteria 2|Bacteria D peptidoglycan glycosyltransferase activity rodA - - ko:K05837 - - - - ko00000,ko03036 - - - FTSW_RODA_SPOVE SRD1_k127_3096445_0 690850.Desaf_0617 2.109e-229 737.0 COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,42NJD@68525|delta/epsilon subdivisions,2WJFK@28221|Deltaproteobacteria,2M7U6@213115|Desulfovibrionales 28221|Deltaproteobacteria O Belongs to the peptidase S16 family - - 3.4.21.53 ko:K01338,ko:K04076,ko:K04770 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA_32,Lon_C SRD1_k127_3096445_1 926550.CLDAP_30940 1.726e-189 602.0 COG0076@1|root,COG0076@2|Bacteria,2G7N6@200795|Chloroflexi 200795|Chloroflexi E Pyridoxal-dependent decarboxylase conserved domain - - 4.1.1.105,4.1.1.28,4.1.2.27 ko:K01593,ko:K01634 ko00350,ko00360,ko00380,ko00600,ko00901,ko00950,ko00965,ko01100,ko01110,ko04071,ko04726,ko04728,ko05030,ko05031,ko05034,map00350,map00360,map00380,map00600,map00901,map00950,map00965,map01100,map01110,map04071,map04726,map04728,map05030,map05031,map05034 M00037,M00042,M00100 R00685,R00699,R00736,R02080,R02464,R02701,R04909,R06516 RC00264,RC00299,RC00721,RC01266 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyridoxal_deC SRD1_k127_3096445_6 204669.Acid345_1630 4.033e-85 289.0 COG1187@1|root,COG1187@2|Bacteria,3Y6Y9@57723|Acidobacteria,2JP1I@204432|Acidobacteriia 204432|Acidobacteriia J RNA pseudouridylate synthase - - 5.4.99.22 ko:K06178 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 SRD1_k127_3096445_10 682795.AciX8_3110 2.863e-28 115.0 COG0383@1|root,COG0383@2|Bacteria,3Y3ID@57723|Acidobacteria,2JINT@204432|Acidobacteriia 2|Bacteria G Glycosyl hydrolase 38 domain protein ams1 - 3.2.1.24 ko:K01191 ko00511,map00511 - - - ko00000,ko00001,ko01000,ko04131 - GH38 - Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C SRD1_k127_310014_0 452637.Oter_1312 8.691e-74 256.0 COG0730@1|root,COG0730@2|Bacteria,46V74@74201|Verrucomicrobia,3K8YW@414999|Opitutae 414999|Opitutae S Sulfite exporter TauE/SafE - - - ko:K07090 - - - - ko00000 - - - TauE SRD1_k127_310014_1 1303518.CCALI_01253 5.751e-53 199.0 COG0526@1|root,COG0526@2|Bacteria 2|Bacteria CO cell redox homeostasis - - - - - - - - - - - - AhpC-TSA,Redoxin,Thioredoxin SRD1_k127_310014_2 945713.IALB_0407 7.493e-50 181.0 COG2070@1|root,COG2070@2|Bacteria 2|Bacteria S nitronate monooxygenase activity fabK - 1.3.1.9 ko:K02371 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00083 R04429,R04724,R04955,R04958,R04961,R04966,R04969,R07765 RC00052,RC00076 ko00000,ko00001,ko00002,ko01000,ko01004 - - - NMO SRD1_k127_3105555_1 903818.KI912268_gene2106 5.89e-113 372.0 COG0348@1|root,COG0348@2|Bacteria,3Y3H4@57723|Acidobacteria 57723|Acidobacteria C 4Fe-4S binding domain - - - - - - - - - - - - Fer4_5 SRD1_k127_3105555_2 945713.IALB_0856 7.151e-34 136.0 COG1959@1|root,COG1959@2|Bacteria 2|Bacteria K 2 iron, 2 sulfur cluster binding - - - - - - - - - - - - Rrf2 SRD1_k127_3105555_3 247490.KSU1_C1034 1.284e-17 93.0 COG3861@1|root,COG3861@2|Bacteria,2IZRE@203682|Planctomycetes 203682|Planctomycetes S electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity - - - - - - - - - - - - PRC SRD1_k127_3105555_0 1123371.ATXH01000029_gene45 7.753e-217 696.0 COG0380@1|root,COG1877@1|root,COG0380@2|Bacteria,COG1877@2|Bacteria,2GH2W@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria G Trehalose-phosphatase - - 2.4.1.15,3.1.3.12 ko:K16055 ko00500,ko01100,map00500,map01100 - R02737,R02778 RC00005,RC00017,RC00049,RC02748 ko00000,ko00001,ko01000,ko01003 - GT20 - Glyco_transf_20,Trehalose_PPase SRD1_k127_3116883_3 1191523.MROS_0107 8.232e-18 87.0 COG3420@1|root,COG3420@2|Bacteria 2|Bacteria P alginic acid biosynthetic process algG - 5.1.3.37 ko:K01795 ko00051,map00051 - R08693 RC00509 ko00000,ko00001,ko01000 - - - Beta_helix,DUF1565,NosD SRD1_k127_3116883_1 926550.CLDAP_19560 9.974e-44 170.0 2EB0S@1|root,3351M@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - SRD1_k127_3116883_2 204669.Acid345_2557 1.99e-37 149.0 2B7KW@1|root,320RZ@2|Bacteria,3Y7ZF@57723|Acidobacteria,2JN97@204432|Acidobacteriia 204432|Acidobacteriia - - - - - - - - - - - - - - - SRD1_k127_3116883_0 945713.IALB_1857 7.115e-100 355.0 COG2208@1|root,COG2208@2|Bacteria 2|Bacteria T phosphoserine phosphatase activity rsbU - 3.1.3.3 ko:K07315 - - - - ko00000,ko01000,ko03021 - - - GAF_2,GAF_3,SpoIIE SRD1_k127_3122872_1 234267.Acid_7808 1.044e-77 274.0 2A6KY@1|root,30VER@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - SRD1_k127_3122872_3 1118054.CAGW01000016_gene4534 3.718e-06 57.0 COG0500@1|root,COG2226@2|Bacteria,1V45D@1239|Firmicutes,4HGZ2@91061|Bacilli,26SJY@186822|Paenibacillaceae 91061|Bacilli Q SAM-dependent methyltransferase ubiE7 - - - - - - - - - - - Methyltransf_11,Methyltransf_25 SRD1_k127_3122872_2 13035.Dacsa_0273 5.072e-69 246.0 COG0500@1|root,COG2226@2|Bacteria 2|Bacteria Q methyltransferase - - - ko:K15256 - - - - ko00000,ko01000,ko03016 - - - Methyltransf_11,Methyltransf_23,Methyltransf_25,Polysacc_synt_C SRD1_k127_3122872_0 65393.PCC7424_2821 7.609e-126 408.0 COG0129@1|root,COG0129@2|Bacteria,1G0KD@1117|Cyanobacteria,3KG5I@43988|Cyanothece 1117|Cyanobacteria H Belongs to the IlvD Edd family ilvD GO:0003674,GO:0003824,GO:0004160,GO:0016829,GO:0016835,GO:0016836 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD SRD1_k127_3148862_5 1463856.JOHY01000009_gene6694 3.405e-12 71.0 COG1175@1|root,COG1175@2|Bacteria,2GX5P@201174|Actinobacteria 201174|Actinobacteria G PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K17330 ko02010,map02010 M00606 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.33 - - BPD_transp_1 SRD1_k127_3148862_3 373903.Hore_20630 2.352e-34 147.0 COG1653@1|root,COG1653@2|Bacteria,1UI64@1239|Firmicutes,25EPF@186801|Clostridia,3WAUS@53433|Halanaerobiales 186801|Clostridia G Extracellular solute-binding protein - - - ko:K02027 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - SBP_bac_8 SRD1_k127_3148862_6 373903.Hore_12950 0.0005927 51.0 COG0407@1|root,COG0407@2|Bacteria,1V7NA@1239|Firmicutes,24MGR@186801|Clostridia 186801|Clostridia H Uroporphyrinogen decarboxylase (URO-D) - - - - - - - - - - - - URO-D SRD1_k127_3148862_0 556261.HMPREF0240_00421 1.005e-244 784.0 COG1882@1|root,COG1882@2|Bacteria,1VTIM@1239|Firmicutes,24EPG@186801|Clostridia,36H8K@31979|Clostridiaceae 186801|Clostridia C Pyruvate formate lyase-like - - - - - - - - - - - - Gly_radical,PFL-like SRD1_k127_3148862_2 697281.Mahau_1338 1.275e-82 285.0 COG1180@1|root,COG1180@2|Bacteria,1TPK2@1239|Firmicutes,24871@186801|Clostridia,42J26@68295|Thermoanaerobacterales 186801|Clostridia C 4Fe-4S single cluster domain yjjW - 1.97.1.4 ko:K04069 - - R04710 - ko00000,ko01000 - - - Fer4_12,Fer4_6,Radical_SAM SRD1_k127_3148862_4 485918.Cpin_6203 6.26e-15 83.0 28PRQ@1|root,2ZCDG@2|Bacteria,4NWY7@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - SRD1_k127_3148862_1 1499683.CCFF01000013_gene325 2.872e-111 369.0 COG2511@1|root,COG2511@2|Bacteria,1UPG0@1239|Firmicutes,25HFT@186801|Clostridia 186801|Clostridia J GatB/GatE catalytic domain - - - - - - - - - - - - GatB_N SRD1_k127_3150429_0 945713.IALB_1370 4.659e-180 589.0 COG1572@1|root,COG1572@2|Bacteria 2|Bacteria NU bacterial-type flagellum-dependent cell motility porU - - - - - - - - - - - Peptidase_C25 SRD1_k127_3150429_1 1191523.MROS_1889 3.687e-121 400.0 COG2067@1|root,COG2067@2|Bacteria 2|Bacteria I long-chain fatty acid transporting porin activity porV - - - - - - - - - - - - SRD1_k127_3153368_2 945713.IALB_2959 4.149e-25 113.0 2DC00@1|root,2ZC4V@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - SRD1_k127_3153368_1 1379698.RBG1_1C00001G0743 1.697e-35 141.0 COG2318@1|root,COG2318@2|Bacteria,2NRHG@2323|unclassified Bacteria 2|Bacteria S DinB superfamily dinB - - ko:K07552 - - - - ko00000,ko02000 2.A.1.2 - - DinB SRD1_k127_3153368_3 545243.BAEV01000170_gene2211 0.0005153 50.0 COG1280@1|root,COG1280@2|Bacteria,1V1Q5@1239|Firmicutes,24CM0@186801|Clostridia,36FF9@31979|Clostridiaceae 186801|Clostridia E LysE type translocator - - - - - - - - - - - - LysE SRD1_k127_3153368_0 945713.IALB_1289 2.199e-179 571.0 COG0249@1|root,COG0249@2|Bacteria 2|Bacteria L mismatched DNA binding mutS GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V SRD1_k127_3156138_2 1247649.D560_3050 1.769e-48 184.0 COG1917@1|root,COG1917@2|Bacteria,1RGXQ@1224|Proteobacteria,2VSZH@28216|Betaproteobacteria,3T4FT@506|Alcaligenaceae 28216|Betaproteobacteria S Cupin 2, conserved barrel domain protein - - - - - - - - - - - - - SRD1_k127_3156138_1 439235.Dalk_1818 1.785e-86 299.0 COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,42M97@68525|delta/epsilon subdivisions,2WJB4@28221|Deltaproteobacteria,2MJB7@213118|Desulfobacterales 28221|Deltaproteobacteria C 4Fe-4S dicluster domain - - - - - - - - - - - - DmsC,Fer4_11,Fer4_4 SRD1_k127_3156138_0 1121396.KB893012_gene4024 1.317e-106 372.0 COG5557@1|root,COG5557@2|Bacteria,1MWYI@1224|Proteobacteria,42PH3@68525|delta/epsilon subdivisions,2WJZH@28221|Deltaproteobacteria,2MIN0@213118|Desulfobacterales 28221|Deltaproteobacteria C Polysulphide reductase, NrfD - - - - - - - - - - - - NrfD SRD1_k127_3159178_0 1303518.CCALI_00158 1.81e-253 787.0 COG0166@1|root,COG0166@2|Bacteria 2|Bacteria G Belongs to the GPI family pgi GO:0003674,GO:0003824,GO:0004347,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0033554,GO:0034404,GO:0034599,GO:0034641,GO:0034654,GO:0034655,GO:0042221,GO:0042802,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0050896,GO:0051186,GO:0051188,GO:0051716,GO:0055086,GO:0070887,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 5.3.1.9 ko:K01810 ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200 M00001,M00004,M00114 R02739,R02740,R03321 RC00376,RC00563 ko00000,ko00001,ko00002,ko01000,ko04147 - - iEcSMS35_1347.EcSMS35_4486 PGI SRD1_k127_3159178_1 518766.Rmar_0472 4.274e-193 615.0 COG0021@1|root,COG0021@2|Bacteria,4P14U@976|Bacteroidetes,1FIXF@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes G Transketolase, thiamine diphosphate binding domain tkt - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C,Transketolase_N SRD1_k127_3166022_3 575540.Isop_1791 3.057e-31 134.0 COG1235@1|root,COG1235@2|Bacteria,2IZQK@203682|Planctomycetes 203682|Planctomycetes S Beta-lactamase superfamily domain - - - - - - - - - - - - Lactamase_B_2 SRD1_k127_3166022_5 1209989.TepiRe1_0542 4.1e-09 66.0 COG0110@1|root,COG0110@2|Bacteria,1V1SM@1239|Firmicutes,25B93@186801|Clostridia,42GXQ@68295|Thermoanaerobacterales 186801|Clostridia S Hexapeptide repeat of succinyl-transferase - - - - - - - - - - - - Hexapep,Hexapep_2 SRD1_k127_3166022_2 583355.Caka_2560 5.118e-66 229.0 COG0225@1|root,COG0225@2|Bacteria,46VCK@74201|Verrucomicrobia,3K83N@414999|Opitutae 414999|Opitutae O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine msrA - 1.8.4.11 ko:K07304 - - - - ko00000,ko01000 - - - PMSR SRD1_k127_3166022_4 749222.Nitsa_1318 4.318e-10 65.0 2EE7S@1|root,3382A@2|Bacteria,1NFK6@1224|Proteobacteria,42XB1@68525|delta/epsilon subdivisions,2YQX5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - SRD1_k127_3166022_0 945713.IALB_2868 1.098e-257 801.0 COG2986@1|root,COG2986@2|Bacteria 2|Bacteria E ammonia-lyase activity hutH - 4.3.1.3 ko:K01745 ko00340,ko01100,map00340,map01100 M00045 R01168 RC00361 ko00000,ko00001,ko00002,ko01000 - - - Lyase_aromatic SRD1_k127_3166022_1 376733.IT41_13410 4.401e-67 240.0 COG0124@1|root,COG0124@2|Bacteria,1MV2K@1224|Proteobacteria,2TSTH@28211|Alphaproteobacteria,2PVHD@265|Paracoccus 28211|Alphaproteobacteria J Histidyl-tRNA synthetase hisS - 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_His SRD1_k127_3186632_1 1121287.AUMU01000003_gene2927 2.56e-09 72.0 COG3291@1|root,COG4733@1|root,COG3291@2|Bacteria,COG4733@2|Bacteria,4NJHV@976|Bacteroidetes,1IKPD@117743|Flavobacteriia,3ZUS4@59732|Chryseobacterium 976|Bacteroidetes S Fibronectin type 3 domain - - - - - - - - - - - - fn3 SRD1_k127_3186632_0 1499967.BAYZ01000105_gene3503 5.585e-14 87.0 COG3420@1|root,COG3420@2|Bacteria 2|Bacteria P alginic acid biosynthetic process - - - - - - - - - - - - Beta_helix,DUF5011 SRD1_k127_3187553_4 1123073.KB899241_gene1843 4.151e-12 68.0 COG5316@1|root,COG5316@2|Bacteria,1QCVP@1224|Proteobacteria,1RQFF@1236|Gammaproteobacteria,1X3Q3@135614|Xanthomonadales 135614|Xanthomonadales S Domain of unknown function (DUF4139) - - - - - - - - - - - - DUF4139 SRD1_k127_3187553_1 247490.KSU1_B0100 2.791e-127 419.0 COG3385@1|root,COG3385@2|Bacteria 2|Bacteria L transposase activity - - - - - - - - - - - - DDE_Tnp_1,DUF4372 SRD1_k127_3187553_0 1122927.KB895413_gene2086 2.843e-289 910.0 COG3250@1|root,COG3250@2|Bacteria,1TPK7@1239|Firmicutes,4HE4D@91061|Bacilli,27499@186822|Paenibacillaceae 91061|Bacilli G Belongs to the glycosyl hydrolase 2 family - - 3.2.1.23 ko:K01190 ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100 - R01105,R01678,R03355,R04783,R06114 RC00049,RC00452 ko00000,ko00001,ko01000 - - - DUF4982,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N SRD1_k127_3187553_2 1173026.Glo7428_1703 1.107e-119 394.0 COG0350@1|root,COG2169@1|root,COG0350@2|Bacteria,COG2169@2|Bacteria,1G0MX@1117|Cyanobacteria 1117|Cyanobacteria L Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated - - 2.1.1.63 ko:K00567,ko:K10778 - - - - ko00000,ko01000,ko03000,ko03400 - - - Ada_Zn_binding,DNA_binding_1,HTH_18,Methyltransf_1N SRD1_k127_3187553_3 1191523.MROS_1655 1.377e-61 219.0 COG1807@1|root,COG1807@2|Bacteria 2|Bacteria M 4-amino-4-deoxy-L-arabinose transferase activity - - - - - - - - - - - - GAF,HATPase_c,HisKA,HisKA_7TM,Hpt,PMT_2,Response_reg SRD1_k127_3189392_1 1144275.COCOR_02230 6.647e-150 489.0 COG0493@1|root,COG0543@1|root,COG0493@2|Bacteria,COG0543@2|Bacteria,1Q2ZJ@1224|Proteobacteria,438P5@68525|delta/epsilon subdivisions,2X8TH@28221|Deltaproteobacteria,2YXE6@29|Myxococcales 28221|Deltaproteobacteria CEH Pyridine nucleotide-disulphide oxidoreductase - - - - - - - - - - - - Pyr_redox_2 SRD1_k127_3189392_7 1191523.MROS_1773 7.279e-13 76.0 COG0789@1|root,COG0789@2|Bacteria 2|Bacteria K bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding - - 2.1.1.37 ko:K00558,ko:K13639,ko:K13640 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03000,ko03032,ko03036 - - - DNA_methylase,MerR,MerR_1 SRD1_k127_3189392_5 497964.CfE428DRAFT_3727 9.915e-28 120.0 2FH6M@1|root,34912@2|Bacteria 2|Bacteria S Domain of unknown function (DUF4203) - - - - - - - - - - - - DUF4203 SRD1_k127_3189392_6 398767.Glov_0553 9.416e-14 76.0 COG0530@1|root,COG0530@2|Bacteria 2|Bacteria P calcium, potassium:sodium antiporter activity - - - ko:K07301 - - - - ko00000,ko02000 2.A.19.5 - - Na_Ca_ex SRD1_k127_3189392_4 211165.AJLN01000113_gene5974 2.673e-31 131.0 COG0454@1|root,COG0456@2|Bacteria,1G7IH@1117|Cyanobacteria 1117|Cyanobacteria K PFAM Acetyltransferase (GNAT) family - - - - - - - - - - - - Acetyltransf_1 SRD1_k127_3189392_3 1442599.JAAN01000024_gene1823 8.45e-60 219.0 COG5483@1|root,COG5483@2|Bacteria,1RDGV@1224|Proteobacteria,1SBHQ@1236|Gammaproteobacteria,1X6JD@135614|Xanthomonadales 135614|Xanthomonadales S Protein of unknown function, DUF488 - - - - - - - - - - - - DUF488 SRD1_k127_3189392_2 56110.Oscil6304_0589 2.057e-91 312.0 COG1801@1|root,COG1801@2|Bacteria,1G2CT@1117|Cyanobacteria,1H914@1150|Oscillatoriales 1117|Cyanobacteria S Protein of unknown function DUF72 - - - - - - - - - - - - DUF72 SRD1_k127_3189392_0 1519464.HY22_09345 3.658e-152 494.0 COG1236@1|root,COG1236@2|Bacteria,1FER3@1090|Chlorobi 1090|Chlorobi J PFAM beta-lactamase domain protein - - - ko:K07576 - - - - ko00000 - - - Beta-Casp,Lactamase_B,RMMBL SRD1_k127_319530_1 477641.MODMU_0871 3.744e-09 63.0 COG0438@1|root,COG0438@2|Bacteria,2IA6I@201174|Actinobacteria 201174|Actinobacteria M Glycosyl transferase - - - - - - - - - - - - Glyco_trans_4_4,Glycos_transf_1 SRD1_k127_319530_0 435591.BDI_3232 3.72e-76 266.0 COG1216@1|root,COG1216@2|Bacteria,4NKAZ@976|Bacteroidetes,2FRDA@200643|Bacteroidia,22XTK@171551|Porphyromonadaceae 976|Bacteroidetes S Glycosyltransferase like family 2 - - - - - - - - - - - - Glycos_transf_2 SRD1_k127_32208_0 1191523.MROS_0601 6.046e-237 744.0 COG0173@1|root,COG0173@2|Bacteria 2|Bacteria J aspartate-tRNA(Asn) ligase activity aspS GO:0003674,GO:0003824,GO:0004812,GO:0004815,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006422,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - iJN678.aspS,iSFV_1184.SFV_1868 GAD,tRNA-synt_2,tRNA_anti-codon SRD1_k127_32208_1 945713.IALB_1492 3.474e-210 662.0 COG3185@1|root,COG3185@2|Bacteria 2|Bacteria E 4-Hydroxyphenylpyruvate dioxygenase - - - - - - - - - - - - AtuA SRD1_k127_32208_3 945713.IALB_1493 8.785e-41 153.0 2CIU6@1|root,32S8H@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - SRD1_k127_32208_2 945713.IALB_1495 3.791e-152 487.0 COG1186@1|root,COG1186@2|Bacteria 2|Bacteria J translation release factor activity prfB GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016149,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02836 - - - - ko00000,ko03012 - - - PCRF,RF-1 SRD1_k127_32208_4 1191523.MROS_2649 6.787e-40 159.0 COG4591@1|root,COG4591@2|Bacteria 2|Bacteria M lipoprotein localization to outer membrane - - - ko:K09808 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko02000 3.A.1.125 - - FtsX,MacB_PCD SRD1_k127_3233318_1 1379270.AUXF01000004_gene3069 4.198e-30 137.0 28M0D@1|root,2ZAFE@2|Bacteria,1ZUP5@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Putative ATP-binding cassette - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran_2 SRD1_k127_3233318_0 1499967.BAYZ01000152_gene1432 8.368e-70 244.0 COG1131@1|root,COG1131@2|Bacteria,2NPDQ@2323|unclassified Bacteria 2|Bacteria V ATPases associated with a variety of cellular activities natA2 - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran SRD1_k127_3233318_2 1121405.dsmv_0796 3.078e-25 110.0 COG0287@1|root,COG0287@2|Bacteria,1QA4K@1224|Proteobacteria,42V3B@68525|delta/epsilon subdivisions,2WRIN@28221|Deltaproteobacteria 28221|Deltaproteobacteria E Prephenate dehydrogenase - - 1.3.1.12 ko:K00210 ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 M00025 R01728 RC00125 ko00000,ko00001,ko00002,ko01000 - - - CM_2,PDH SRD1_k127_324041_5 1408226.T233_01516 3.242e-05 49.0 COG1609@1|root,COG1609@2|Bacteria,1TQSQ@1239|Firmicutes,4HBNR@91061|Bacilli,4B66I@81852|Enterococcaceae 91061|Bacilli K helix_turn _helix lactose operon repressor ccpB - - - - - - - - - - - LacI,Peripla_BP_1 SRD1_k127_324041_0 1121022.ABENE_07165 1.883e-226 737.0 COG1501@1|root,COG1501@2|Bacteria,1MWNJ@1224|Proteobacteria 1224|Proteobacteria G Belongs to the glycosyl hydrolase 31 family - - 3.2.1.177 ko:K01811 - - - - ko00000,ko01000 - GH31 - DUF4968,DUF5110,Glyco_hydro_31,PA14 SRD1_k127_324041_2 234267.Acid_6968 3.591e-75 259.0 COG5012@1|root,COG5012@2|Bacteria,3Y88D@57723|Acidobacteria 57723|Acidobacteria S B12 binding domain - - - - - - - - - - - - B12-binding,B12-binding_2 SRD1_k127_324041_3 234267.Acid_2673 1.919e-60 221.0 COG0646@1|root,COG0646@2|Bacteria,3Y7SY@57723|Acidobacteria 57723|Acidobacteria E Homocysteine S-methyltransferase - - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - S-methyl_trans SRD1_k127_324041_4 755731.Clo1100_3854 1.404e-41 162.0 COG0145@1|root,COG0145@2|Bacteria,1V3GN@1239|Firmicutes,24FHU@186801|Clostridia,36W2B@31979|Clostridiaceae 186801|Clostridia EQ Protein of unknown function (DUF1638) - - - - - - - - - - - - DUF1638 SRD1_k127_324041_1 742725.HMPREF9450_01261 3.109e-98 332.0 COG2871@1|root,COG3894@1|root,COG2871@2|Bacteria,COG3894@2|Bacteria,4PAMG@976|Bacteroidetes,2FXAJ@200643|Bacteroidia 976|Bacteroidetes C Domain of unknown function (DUF4445) - - - - - - - - - - - - DUF4445,Fer2 SRD1_k127_325357_0 234267.Acid_1102 2.616e-45 183.0 COG0642@1|root,COG2205@2|Bacteria,3Y4AU@57723|Acidobacteria 57723|Acidobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA SRD1_k127_3260533_0 404589.Anae109_3957 2.001e-104 353.0 COG0312@1|root,COG0312@2|Bacteria,1RBJZ@1224|Proteobacteria,42YBE@68525|delta/epsilon subdivisions,2WUP7@28221|Deltaproteobacteria,2YZ4Y@29|Myxococcales 28221|Deltaproteobacteria L Putative modulator of DNA gyrase - - - ko:K03592 - - - - ko00000,ko01002 - - - PmbA_TldD SRD1_k127_3260533_2 641491.DND132_3180 1.18e-21 106.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,42NB6@68525|delta/epsilon subdivisions,2WIWE@28221|Deltaproteobacteria,2M7YQ@213115|Desulfovibrionales 28221|Deltaproteobacteria M Belongs to the peptidase S1C family degP - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 SRD1_k127_3260533_1 1499967.BAYZ01000195_gene3106 3.979e-60 226.0 COG1807@1|root,COG1807@2|Bacteria,2NPZC@2323|unclassified Bacteria 2|Bacteria M Dolichyl-phosphate-mannose-protein mannosyltransferase MA20_19960 - - - - - - - - - - - PMT_2 SRD1_k127_3261934_2 309807.SRU_2340 2.685e-10 64.0 COG1158@1|root,COG1158@2|Bacteria,4NZWZ@976|Bacteroidetes,1FIJE@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template - - - ko:K03628 ko03018,map03018 - - - ko00000,ko00001,ko03019,ko03021 - - - ATP-synt_ab,Rho_RNA_bind SRD1_k127_3261934_0 1459636.NTE_00013 9.183e-59 211.0 COG2085@1|root,arCOG00457@2157|Archaea 2157|Archaea S NADPH-dependent F420 reductase - - 1.5.1.40 ko:K06988 - - - - ko00000,ko01000 - - - F420_oxidored,HTH_10 SRD1_k127_3261934_1 909663.KI867150_gene2235 8.624e-49 181.0 COG2733@1|root,COG2733@2|Bacteria,1MX3G@1224|Proteobacteria,42UZD@68525|delta/epsilon subdivisions,2WQX5@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Protein of unknown function (DUF445) - - - - - - - - - - - - DUF445 SRD1_k127_3265351_0 1124780.ANNU01000032_gene1226 7.957e-271 848.0 COG3250@1|root,COG3250@2|Bacteria,4NEDP@976|Bacteroidetes,47JV2@768503|Cytophagia 976|Bacteroidetes G Belongs to the glycosyl hydrolase 2 family - - 3.1.1.53 ko:K05970 - - - - ko00000,ko01000 - - - Glyco_hydro_2_N,SASA SRD1_k127_3265351_4 1121859.KB890739_gene2172 1.109e-84 291.0 COG1028@1|root,COG1028@2|Bacteria,4NIH6@976|Bacteroidetes,47MQG@768503|Cytophagia 976|Bacteroidetes IQ PFAM Short-chain dehydrogenase reductase SDR - - 1.1.1.69 ko:K00046 - - - - ko00000,ko01000 - - - adh_short_C2 SRD1_k127_3265351_1 1163408.UU9_13433 7.91e-170 544.0 COG2271@1|root,COG2271@2|Bacteria,1MV04@1224|Proteobacteria,1RP70@1236|Gammaproteobacteria,1X56Y@135614|Xanthomonadales 135614|Xanthomonadales G Major facilitator superfamily - - - ko:K08191 - - - - ko00000,ko02000 2.A.1.14.2 - - MFS_1 SRD1_k127_3265351_6 1191523.MROS_2080 2.16e-20 106.0 COG0737@1|root,COG3693@1|root,COG0737@2|Bacteria,COG3693@2|Bacteria 2|Bacteria G endo-1,4-beta-xylanase activity xynX5 - 3.2.1.202,3.2.1.8 ko:K01181,ko:K21606 - - - - ko00000,ko01000 - CBM5,GH18 - 5_nucleotid_C,CBM_4_9,LRR_5,Metallophos,Phytase-like,SLH SRD1_k127_3265351_5 1304880.JAGB01000002_gene1695 5.011e-48 192.0 COG3693@1|root,COG3693@2|Bacteria,1V0MH@1239|Firmicutes,25B99@186801|Clostridia 186801|Clostridia G Glycosyl hydrolase family 10 - - 3.2.1.8 ko:K01181 - - - - ko00000,ko01000 - - - CBM_4_9,Glyco_hydro_10 SRD1_k127_3265351_2 1191523.MROS_2090 7.603e-156 516.0 COG5520@1|root,COG5520@2|Bacteria 2|Bacteria M Belongs to the glycosyl hydrolase 30 family - - 3.2.1.136 ko:K15924 - - - - ko00000,ko01000 - GH5 - CBM_2,Glyco_hydr_30_2,Glyco_hydro_30,Glyco_hydro_30C SRD1_k127_3265351_3 714943.Mucpa_3303 1.869e-101 340.0 COG1874@1|root,COG1874@2|Bacteria,4NDX1@976|Bacteroidetes,1IX44@117747|Sphingobacteriia 976|Bacteroidetes G Beta-galactosidase - - - - - - - - - - - - Glyco_hydro_35,Glyco_hydro_42 SRD1_k127_3267544_1 1157943.KB892705_gene335 2.74e-07 56.0 COG1175@1|root,COG1175@2|Bacteria,2GM6N@201174|Actinobacteria,234RG@1762|Mycobacteriaceae 201174|Actinobacteria P ABC transporter sugA GO:0008150,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044403,GO:0044419,GO:0051704 - ko:K02025 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - iNJ661.Rv1236 BPD_transp_1 SRD1_k127_3267544_0 671143.DAMO_0102 7.164e-84 293.0 COG4772@1|root,COG4772@2|Bacteria,2NRIP@2323|unclassified Bacteria 2|Bacteria P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec SRD1_k127_3276803_0 1279009.ADICEAN_02346 6.198e-81 276.0 COG0604@1|root,COG0604@2|Bacteria,4NKEF@976|Bacteroidetes,47RHN@768503|Cytophagia 976|Bacteroidetes C Alcohol dehydrogenase GroES-like domain - - - - - - - - - - - - ADH_N,ADH_zinc_N SRD1_k127_3276803_1 945713.IALB_2746 1.611e-71 246.0 COG2353@1|root,COG2353@2|Bacteria 2|Bacteria O YceI-like domain - - - - - - - - - - - - YceI SRD1_k127_3276803_2 1124780.ANNU01000054_gene3516 7.294e-61 215.0 COG0664@1|root,COG0664@2|Bacteria,4NM4K@976|Bacteroidetes,47PUR@768503|Cytophagia 976|Bacteroidetes K Cyclic nucleotide-monophosphate binding domain - - - - - - - - - - - - Crp,cNMP_binding SRD1_k127_3276803_4 379066.GAU_3295 1.697e-33 138.0 COG2259@1|root,COG2259@2|Bacteria 2|Bacteria S methylamine metabolic process doxD - - ko:K15977 - - - - ko00000 - - - DoxX SRD1_k127_3276803_3 1173023.KE650771_gene3455 3.411e-41 155.0 COG0662@1|root,COG0662@2|Bacteria,1GKNW@1117|Cyanobacteria,1JMH2@1189|Stigonemataceae 1117|Cyanobacteria G Cupin domain - - - - - - - - - - - - Cupin_2 SRD1_k127_3296038_0 1313265.JNIE01000002_gene889 2.124e-85 289.0 COG0367@1|root,COG0367@2|Bacteria 2|Bacteria E asparagine synthase asnB - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 SRD1_k127_3296038_1 143224.JQMD01000002_gene3412 3.011e-72 265.0 COG0438@1|root,COG0438@2|Bacteria,4NW2W@976|Bacteroidetes 976|Bacteroidetes M Glycosyltransferase, group 1 family protein - - - - - - - - - - - - Glyco_trans_1_4,Glycos_transf_1 SRD1_k127_3296038_2 1173024.KI912149_gene6087 2.053e-25 118.0 COG1216@1|root,COG1216@2|Bacteria,1G8NN@1117|Cyanobacteria 1117|Cyanobacteria S Glycosyltransferase like family 2 - - - - - - - - - - - - Glycos_transf_2 SRD1_k127_3296038_3 497964.CfE428DRAFT_3074 0.0005206 47.0 COG1216@1|root,COG1216@2|Bacteria 2|Bacteria V Glycosyl transferase, family 2 - GO:0003674,GO:0003824,GO:0016740,GO:0016757 - - - - - - - - - - Glycos_transf_2 SRD1_k127_3299494_0 880073.Calab_3441 2.427e-49 179.0 COG0235@1|root,COG0235@2|Bacteria,2NQFY@2323|unclassified Bacteria 2|Bacteria G Class II Aldolase and Adducin N-terminal domain - - 2.2.1.8,4.1.2.17 ko:K01628,ko:K18847 ko00051,ko01120,map00051,map01120 - R02262 RC00603,RC00604 ko00000,ko00001,ko01000 - - - Aldolase_II SRD1_k127_3299494_1 56110.Oscil6304_1395 1.29e-46 183.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD SRD1_k127_3299494_2 903818.KI912269_gene253 1.145e-19 96.0 COG1136@1|root,COG1136@2|Bacteria,3Y7RH@57723|Acidobacteria 57723|Acidobacteria V ABC transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran SRD1_k127_3304360_7 130081.XP_005709311.1 1.531e-11 74.0 COG0169@1|root,KOG0692@2759|Eukaryota 2759|Eukaryota E shikimate 3-dehydrogenase (NADP+) activity - GO:0000003,GO:0003006,GO:0003674,GO:0003824,GO:0004764,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0007275,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009790,GO:0009791,GO:0009793,GO:0009987,GO:0010154,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0022414,GO:0032501,GO:0032502,GO:0032787,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0046417,GO:0048316,GO:0048608,GO:0048731,GO:0048856,GO:0055114,GO:0061458,GO:0071704,GO:1901576,GO:1901615 1.1.1.25,4.2.1.10 ko:K13832 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02413,R03084 RC00206,RC00848 ko00000,ko00001,ko00002,ko01000 - - - DHquinase_I,Shikimate_DH,Shikimate_dh_N SRD1_k127_3304360_4 398767.Glov_1592 3.269e-86 297.0 COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,42MW5@68525|delta/epsilon subdivisions,2WJKR@28221|Deltaproteobacteria,43TT5@69541|Desulfuromonadales 28221|Deltaproteobacteria F Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) aroB - 2.7.1.71,4.2.3.4 ko:K01735,ko:K13829 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412,R03083 RC00002,RC00078,RC00847 ko00000,ko00001,ko00002,ko01000 - - - DHQ_synthase,SKI SRD1_k127_3304360_6 1089550.ATTH01000001_gene1686 2.427e-73 254.0 COG0500@1|root,COG2226@2|Bacteria,4NEDR@976|Bacteroidetes,1FJ8B@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes H Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) menG - 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 - - - Ubie_methyltran SRD1_k127_3304360_5 436114.SYO3AOP1_1029 9.892e-79 272.0 COG2107@1|root,COG2107@2|Bacteria,2G4EE@200783|Aquificae 200783|Aquificae S Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) mqnD - - ko:K11785 ko00130,ko01110,map00130,map01110 - R08589 RC02330 ko00000,ko00001,ko01000 - - - VitK2_biosynth SRD1_k127_3304360_3 1095769.CAHF01000006_gene1870 2.313e-89 302.0 2DB86@1|root,2Z7QD@2|Bacteria,1MX4S@1224|Proteobacteria,2VKPI@28216|Betaproteobacteria 28216|Betaproteobacteria S Nucleotidyl transferase of unknown function (DUF2204) - - - - - - - - - - - - NTP_transf_5 SRD1_k127_3304360_2 1128421.JAGA01000004_gene2491 1.078e-95 319.0 COG2129@1|root,COG2129@2|Bacteria 2|Bacteria L metallophosphoesterase - - - ko:K07096 - - - - ko00000 - - - Metallophos,Metallophos_2 SRD1_k127_3304360_1 1229831.M832_06230 7.153e-105 355.0 COG1060@1|root,COG1060@2|Bacteria 2|Bacteria H 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase activity mqnC GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016765,GO:0044237,GO:0044249,GO:0044689,GO:0051186,GO:0051188 1.21.98.1,2.5.1.120,2.5.1.77 ko:K11779,ko:K11780,ko:K11781,ko:K11784,ko:K18285 ko00130,ko00680,ko01110,ko01120,map00130,map00680,map01110,map01120 M00378 R08588,R09396,R10667 RC00021,RC01381,RC02329,RC03002,RC03007,RC03234 ko00000,ko00001,ko00002,ko01000 - - - Radical_SAM SRD1_k127_3304360_0 1158338.JNLJ01000005_gene1769 1.274e-106 366.0 COG1060@1|root,COG1060@2|Bacteria,2G3M7@200783|Aquificae 200783|Aquificae H Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate mqnE - 2.5.1.120 ko:K18285 ko00130,ko01110,map00130,map01110 - R10667 RC00021,RC03234 ko00000,ko00001,ko01000 - - - Fer4_14,Radical_SAM SRD1_k127_3333770_2 309807.SRU_1850 3.791e-34 149.0 COG0457@1|root,COG1729@1|root,COG0457@2|Bacteria,COG1729@2|Bacteria,4NE2V@976|Bacteroidetes,1FIZ4@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_19,TPR_6,TPR_8 SRD1_k127_3333770_0 518766.Rmar_1962 3.845e-128 421.0 COG0743@1|root,COG0743@2|Bacteria,4NG0S@976|Bacteroidetes,1FIKG@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes I Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) dxr GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576 1.1.1.267 ko:K00099 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05688 RC01452 ko00000,ko00001,ko00002,ko01000 - - - DXPR_C,DXP_redisom_C,DXP_reductoisom SRD1_k127_3333770_1 945713.IALB_0309 1.541e-114 383.0 COG0750@1|root,COG0750@2|Bacteria 2|Bacteria M metalloendopeptidase activity rseP - - ko:K11749 ko02024,ko04112,map02024,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_M50 SRD1_k127_3345793_3 1191523.MROS_0982 8.798e-26 109.0 COG4677@1|root,COG4677@2|Bacteria 2|Bacteria G pectinesterase activity - - 3.2.1.51,4.2.2.23 ko:K10297,ko:K15923,ko:K18197 ko00511,map00511 - - - ko00000,ko00001,ko01000,ko04121 - GH95,PL11 - Beta_helix,CBM_35,Glyco_hydro_98M SRD1_k127_3345793_1 1519464.HY22_10700 3.919e-115 382.0 COG1609@1|root,COG1609@2|Bacteria 2|Bacteria K purine nucleotide biosynthetic process - - - ko:K02529 - - - - ko00000,ko03000 - - - GntR,LacI,Peripla_BP_1,Peripla_BP_3 SRD1_k127_3345793_0 1121124.JNIX01000010_gene748 1.091e-162 534.0 COG3250@1|root,COG3250@2|Bacteria,1MVBN@1224|Proteobacteria,2V27E@28211|Alphaproteobacteria,2KJ2P@204458|Caulobacterales 204458|Caulobacterales G Glycosyl hydrolases family 2, TIM barrel domain - - - - - - - - - - - - Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N SRD1_k127_3345793_2 382464.ABSI01000010_gene3488 3.446e-94 329.0 COG0591@1|root,COG0591@2|Bacteria 2|Bacteria E symporter activity - - - ko:K03307 - - - - ko00000 2.A.21 - - SSF SRD1_k127_3362167_0 945713.IALB_0387 5.577e-81 289.0 COG2204@1|root,COG2204@2|Bacteria 2|Bacteria T phosphorelay signal transduction system - - - ko:K07713 ko02020,map02020 M00499 - - ko00000,ko00001,ko00002,ko02022 - - - GAF,HTH_8,Sigma54_activat SRD1_k127_3362167_1 1173027.Mic7113_1477 7.175e-16 91.0 COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,1G135@1117|Cyanobacteria,1H7GW@1150|Oscillatoriales 1117|Cyanobacteria O Tetratricopeptide repeat - - - - - - - - - - - - CHAT,TPR_12,TPR_7,TPR_8 SRD1_k127_3364768_1 880073.Calab_0041 6.73e-20 100.0 COG4447@1|root,COG4447@2|Bacteria 2|Bacteria S cellulose binding - - 1.14.18.1 ko:K00505 ko00350,ko00950,ko00965,ko01100,ko01110,ko04916,map00350,map00950,map00965,map01100,map01110,map04916 M00042 R00731,R02078,R02363,R02383,R04693,R04884 RC00046,RC00150,RC00180 ko00000,ko00001,ko00002,ko01000 - - - BNR,FlgD_ig,Peptidase_S74,Tyrosinase SRD1_k127_3364768_0 697281.Mahau_0634 6.72e-55 204.0 COG3537@1|root,COG3537@2|Bacteria,1TQAG@1239|Firmicutes,24H3B@186801|Clostridia 186801|Clostridia G Glycosyl hydrolase family 92 - - - - - - - - - - - - Glyco_hydro_92 SRD1_k127_3368910_1 382464.ABSI01000010_gene3823 8.32e-53 192.0 COG0673@1|root,COG0673@2|Bacteria,46U83@74201|Verrucomicrobia,2IWIQ@203494|Verrucomicrobiae 203494|Verrucomicrobiae S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA SRD1_k127_3368910_0 234267.Acid_0577 2.639e-197 624.0 COG2081@1|root,COG2081@2|Bacteria 2|Bacteria N HI0933 family - - - ko:K07007 - - - - ko00000 - - - FAD_oxidored,HI0933_like SRD1_k127_3375387_1 477228.YO5_19727 7.787e-27 126.0 COG3523@1|root,COG3523@2|Bacteria,1MV3D@1224|Proteobacteria,1RPQ2@1236|Gammaproteobacteria,1Z2CB@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria S type VI secretion protein icmF2 - - ko:K11891 ko02025,ko03070,map02025,map03070 M00334 - - ko00000,ko00001,ko00002,ko02044 3.A.23.1 - - IcmF-related,IcmF_C,ImcF-related_N SRD1_k127_3375387_0 330214.NIDE1974 2.043e-33 141.0 COG3913@1|root,COG3913@2|Bacteria 2|Bacteria T Uncharacterized protein conserved in bacteria (DUF2094) - - - ko:K11890,ko:K11910 ko02025,map02025 M00334 - - ko00000,ko00001,ko00002,ko02044 3.A.23.1 - - DUF2094 SRD1_k127_3376253_1 868864.Dester_0028 2.402e-48 175.0 COG0347@1|root,COG0347@2|Bacteria,2G43N@200783|Aquificae 200783|Aquificae K Belongs to the P(II) protein family - - - ko:K04751 ko02020,map02020 - - - ko00000,ko00001 - - - P-II SRD1_k127_3376253_0 945713.IALB_2283 0.0 1303.0 COG0653@1|root,COG0653@2|Bacteria 2|Bacteria U protein targeting secA GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW SRD1_k127_3384383_0 521045.Kole_0692 2.499e-86 296.0 COG1175@1|root,COG1175@2|Bacteria,2GC8J@200918|Thermotogae 200918|Thermotogae P PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02025,ko:K17242 ko02010,map02010 M00207,M00600 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.39 - - BPD_transp_1 SRD1_k127_3384383_1 697281.Mahau_0771 1.513e-81 280.0 COG0395@1|root,COG0395@2|Bacteria,1TSAB@1239|Firmicutes,25C5T@186801|Clostridia,42JEU@68295|Thermoanaerobacterales 186801|Clostridia P COGs COG0395 ABC-type sugar transport system permease component - - - ko:K02026 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 SRD1_k127_3384383_2 1944.JOAZ01000008_gene862 4.836e-07 61.0 COG1196@1|root,COG1196@2|Bacteria,2GNKF@201174|Actinobacteria 201174|Actinobacteria DG Ricin-type beta-trefoil - - - - - - - - - - - - F5_F8_type_C,He_PIG,RicinB_lectin_2,Ricin_B_lectin SRD1_k127_3420245_4 1382356.JQMP01000001_gene699 9.89e-16 89.0 COG5012@1|root,COG5012@2|Bacteria,2G6R8@200795|Chloroflexi 200795|Chloroflexi K PFAM regulatory protein, MerR - - - - - - - - - - - - B12-binding,B12-binding_2,MerR_1 SRD1_k127_3420245_3 690850.Desaf_0357 6.503e-17 90.0 COG2155@1|root,COG2155@2|Bacteria,1N77I@1224|Proteobacteria 1224|Proteobacteria S Domain of unknown function (DUF378) - - - ko:K09779 - - - - ko00000 - - - DUF378 SRD1_k127_3420245_2 639030.JHVA01000001_gene547 2.884e-39 155.0 COG4276@1|root,COG4276@2|Bacteria,3Y57N@57723|Acidobacteria,2JNAU@204432|Acidobacteriia 204432|Acidobacteriia S Pfam Polyketide cyclase dehydrase and lipid transport - - - - - - - - - - - - - SRD1_k127_3420245_0 945713.IALB_0332 5.396e-257 818.0 COG1629@1|root,COG4771@2|Bacteria 2|Bacteria P TonB-dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_C,TonB_dep_Rec SRD1_k127_3420245_1 1408473.JHXO01000001_gene1962 2.715e-61 216.0 COG0667@1|root,COG0667@2|Bacteria,4PPAM@976|Bacteroidetes,2G14T@200643|Bacteroidia 976|Bacteroidetes C Aldo/keto reductase family - - - - - - - - - - - - Aldo_ket_red SRD1_k127_3453019_1 153721.MYP_1181 1.477e-116 383.0 COG0498@1|root,COG0498@2|Bacteria,4NEAA@976|Bacteroidetes,47KUN@768503|Cytophagia 976|Bacteroidetes E Threonine synthase thrC - 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 - - - PALP,Thr_synth_N SRD1_k127_3453019_2 1185876.BN8_06700 1.217e-69 245.0 COG2085@1|root,COG2085@2|Bacteria,4NEC7@976|Bacteroidetes,47QUG@768503|Cytophagia 976|Bacteroidetes S NADP oxidoreductase coenzyme F420-dependent - - 1.5.1.40 ko:K06988 - - - - ko00000,ko01000 - - - F420_oxidored SRD1_k127_3453019_0 1192034.CAP_6731 4.815e-141 461.0 COG0312@1|root,COG0312@2|Bacteria,1MUSK@1224|Proteobacteria,42Y66@68525|delta/epsilon subdivisions,2WU83@28221|Deltaproteobacteria,2YX71@29|Myxococcales 28221|Deltaproteobacteria S Putative modulator of DNA gyrase - - - ko:K03568 - - - - ko00000,ko01002 - - - PmbA_TldD SRD1_k127_3455579_3 1231190.NA8A_02200 7.278e-21 96.0 COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,2TWBA@28211|Alphaproteobacteria,43HY8@69277|Phyllobacteriaceae 28211|Alphaproteobacteria C Transketolase, pyrimidine binding domain - - 1.2.4.4 ko:K11381 ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130 M00036 R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997 RC00027,RC00627,RC02743,RC02883,RC02949,RC02953 br01601,ko00000,ko00001,ko00002,ko01000 - - - E1_dh,Transket_pyr,Transketolase_C SRD1_k127_3455579_1 1265490.JHVY01000003_gene3054 6.934e-51 190.0 COG1028@1|root,COG1028@2|Bacteria,1MU6X@1224|Proteobacteria,1RMBB@1236|Gammaproteobacteria 1236|Gammaproteobacteria IQ reductase - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 SRD1_k127_3455579_0 696369.KI912183_gene1371 1.214e-87 306.0 COG3875@1|root,COG3875@2|Bacteria,1TQ1C@1239|Firmicutes,247PH@186801|Clostridia,261WJ@186807|Peptococcaceae 186801|Clostridia S conserved protein (DUF2088) - - - - - - - - - - - - DUF2088 SRD1_k127_3455579_2 134676.ACPL_4175 4.81e-38 143.0 COG1028@1|root,COG1028@2|Bacteria,2IAK8@201174|Actinobacteria 201174|Actinobacteria IQ Dehydrogenases with different specificities (Related to short-chain alcohol dehydrogenases) - - - - - - - - - - - - adh_short_C2 SRD1_k127_3478021_1 945713.IALB_1538 1.82e-36 144.0 COG1610@1|root,COG1610@2|Bacteria 2|Bacteria S carbon-nitrogen ligase activity, with glutamine as amido-N-donor yqeY - - ko:K09117 - - - - ko00000 - - - YqeY SRD1_k127_3478021_0 326427.Cagg_1922 8.421e-41 160.0 COG1028@1|root,COG1028@2|Bacteria,2G8JD@200795|Chloroflexi,3765Q@32061|Chloroflexia 32061|Chloroflexia IQ short-chain dehydrogenase reductase SDR - - - - - - - - - - - - adh_short SRD1_k127_348169_3 744979.R2A130_0264 1.386e-13 78.0 COG2928@1|root,COG2928@2|Bacteria,1MWT5@1224|Proteobacteria,2TZPK@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function (DUF502) MA20_12960 - - - - - - - - - - - DUF502 SRD1_k127_348169_0 269799.Gmet_1275 3.908e-74 257.0 COG1212@1|root,COG1212@2|Bacteria,1MUUU@1224|Proteobacteria,42PTX@68525|delta/epsilon subdivisions,2WMQW@28221|Deltaproteobacteria,43T2I@69541|Desulfuromonadales 28221|Deltaproteobacteria F Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria kdsB - 2.7.7.38 ko:K00979 ko00540,ko01100,map00540,map01100 M00063 R03351,R11396 RC00152,RC00910 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CTP_transf_3 SRD1_k127_348169_2 945713.IALB_2044 1.207e-25 109.0 COG0721@1|root,COG0721@2|Bacteria 2|Bacteria J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatC - 6.3.5.6,6.3.5.7 ko:K02435 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - iAF987.Gmet_0076 Glu-tRNAGln SRD1_k127_348169_1 96561.Dole_0983 6.807e-42 164.0 COG0204@1|root,COG0204@2|Bacteria,1MY51@1224|Proteobacteria,42S1J@68525|delta/epsilon subdivisions,2WP2S@28221|Deltaproteobacteria,2MJG9@213118|Desulfobacterales 28221|Deltaproteobacteria I Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family - - 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase SRD1_k127_348169_4 880073.Calab_0342 1.661e-05 47.0 COG0501@1|root,COG0501@2|Bacteria,2NP9X@2323|unclassified Bacteria 2|Bacteria O CAAX prenyl protease N-terminal, five membrane helices agmM - 3.4.24.84 ko:K06013 ko00900,ko01130,map00900,map01130 - R09845 RC00141 ko00000,ko00001,ko01000,ko01002,ko04147 - - - Peptidase_M48,Peptidase_M48_N SRD1_k127_3485997_3 234267.Acid_0393 1.811e-34 138.0 COG1913@1|root,COG1913@2|Bacteria 2|Bacteria S metallopeptidase activity - - - ko:K06974 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M54 SRD1_k127_3485997_0 945713.IALB_2429 1.244e-173 555.0 COG2204@1|root,COG2204@2|Bacteria 2|Bacteria T phosphorelay signal transduction system - - - ko:K02481,ko:K07713,ko:K07714 ko02020,map02020 M00499,M00500 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat SRD1_k127_3485997_2 204669.Acid345_2603 3.318e-118 400.0 COG4191@1|root,COG4191@2|Bacteria,3Y42C@57723|Acidobacteria,2JP3M@204432|Acidobacteriia 57723|Acidobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HAMP,HATPase_c,HisKA SRD1_k127_3485997_1 234267.Acid_4205 1.631e-120 398.0 COG5557@1|root,COG5557@2|Bacteria,3Y3RF@57723|Acidobacteria 57723|Acidobacteria C Polysulphide reductase, NrfD - - - - - - - - - - - - NrfD SRD1_k127_3485997_4 1121920.AUAU01000012_gene2649 8.336e-27 111.0 COG0437@1|root,COG0437@2|Bacteria,3Y5RE@57723|Acidobacteria 57723|Acidobacteria C 4Fe-4S dicluster domain - - - - - - - - - - - - Fer4_11 SRD1_k127_349397_7 485918.Cpin_2576 8.864e-35 134.0 COG1523@1|root,COG1523@2|Bacteria,4NIH2@976|Bacteroidetes,1IR47@117747|Sphingobacteriia 976|Bacteroidetes G glycogen debranching enzyme GlgX glgX - 3.2.1.68 ko:K01214 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R09995,R11261 - ko00000,ko00001,ko00002,ko01000 - CBM48,GH13 - Alpha-amylase,CBM_48 SRD1_k127_349397_0 479434.Sthe_2691 9.303e-258 808.0 COG1523@1|root,COG1523@2|Bacteria,2G86B@200795|Chloroflexi 200795|Chloroflexi G Belongs to the glycosyl hydrolase 13 family - - 3.2.1.68 ko:K01214 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R09995,R11261 - ko00000,ko00001,ko00002,ko01000 - CBM48,GH13 - Alpha-amylase,CBM_48 SRD1_k127_349397_6 861299.J421_0494 3.325e-91 314.0 COG1879@1|root,COG1879@2|Bacteria,1ZV3Z@142182|Gemmatimonadetes 2|Bacteria G Periplasmic binding proteins and sugar binding domain of LacI family rbsB - - ko:K10439 ko02010,ko02030,map02010,map02030 M00212 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 - - Peripla_BP_4 SRD1_k127_349397_5 861299.J421_0493 2.533e-98 332.0 COG1172@1|root,COG1172@2|Bacteria,1ZUX9@142182|Gemmatimonadetes 2|Bacteria U Branched-chain amino acid transport system / permease component rbsC GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008643,GO:0015144,GO:0015145,GO:0015146,GO:0015591,GO:0015749,GO:0015750,GO:0015752,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0032991,GO:0034219,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - ko:K10439,ko:K10440 ko02010,ko02030,map02010,map02030 M00212 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 - - BPD_transp_2,Peripla_BP_4 SRD1_k127_349397_2 1009370.ALO_16172 1.201e-161 523.0 COG1129@1|root,COG1129@2|Bacteria,1TP6I@1239|Firmicutes,4H2EG@909932|Negativicutes 909932|Negativicutes G ABC transporter - - - ko:K17215 ko02010,map02010 M00593 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2 - - ABC_tran SRD1_k127_349397_4 575540.Isop_2355 4.001e-117 388.0 COG3509@1|root,COG3509@2|Bacteria,2IYD5@203682|Planctomycetes 203682|Planctomycetes Q Carbohydrate family 9 binding domain-like - - - - - - - - - - - - CBM9_1 SRD1_k127_349397_1 1191523.MROS_1490 1.825e-209 672.0 COG4948@1|root,COG4948@2|Bacteria 2|Bacteria M carboxylic acid catabolic process - - 3.2.1.20 ko:K01187 ko00052,ko00500,ko01100,map00052,map00500,map01100 - R00028,R00801,R00802,R06087,R06088 RC00028,RC00049,RC00077 ko00000,ko00001,ko01000 - GH31 - GH97_C,GH97_N,Glyco_hydro_97 SRD1_k127_349397_8 1191523.MROS_1582 2.602e-09 65.0 COG1361@1|root,COG1361@2|Bacteria 2|Bacteria M extracellular matrix structural constituent - - - - - - - - - - - - FlgD_ig,Fn3-like,Glyco_hydro_3_C,SLH SRD1_k127_349397_3 667632.KB890217_gene4870 1.681e-117 396.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2VH16@28216|Betaproteobacteria,1K3N3@119060|Burkholderiaceae 28216|Betaproteobacteria JKL DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA rhlE GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008026,GO:0008104,GO:0008150,GO:0008186,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033036,GO:0035770,GO:0036464,GO:0042623,GO:0043186,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044444,GO:0044464,GO:0045495,GO:0051179,GO:0060293,GO:0070035,GO:0140098,GO:1990904 3.6.4.13 ko:K11927 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DEAD,Helicase_C SRD1_k127_3494346_0 1121422.AUMW01000009_gene3340 0.0 1181.0 COG1882@1|root,COG1882@2|Bacteria,1TPTF@1239|Firmicutes,247YY@186801|Clostridia,2618A@186807|Peptococcaceae 186801|Clostridia C Glycine radical enzyme that catalyzes the cleavage of a C-N bond in choline, producing trimethylamine (TMA) and acetaldehyde - - 2.3.1.54,4.3.99.4 ko:K00656,ko:K20038 ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120 - R00212,R06987 RC00004,RC01181,RC02742,RC02833 ko00000,ko00001,ko01000 - - - Gly_radical,PFL-like SRD1_k127_3494346_1 768704.Desmer_3088 5.227e-92 318.0 COG1180@1|root,COG1180@2|Bacteria,1TPK2@1239|Firmicutes,24871@186801|Clostridia,261PP@186807|Peptococcaceae 186801|Clostridia C TIGRFAM glycyl-radical enzyme activating protein family csdA - 1.97.1.4 ko:K04069 - - R04710 - ko00000,ko01000 - - - Fer4,Fer4_12,Radical_SAM SRD1_k127_3527766_2 1237149.C900_01886 1.322e-57 205.0 COG1649@1|root,COG1649@2|Bacteria,4NGFW@976|Bacteroidetes,47T3X@768503|Cytophagia 976|Bacteroidetes S PFAM Uncharacterised BCR, COG1649 - - - - - - - - - - - - CBM9_1,GHL10 SRD1_k127_3527766_0 326427.Cagg_2725 3.625e-152 503.0 COG1807@1|root,COG1807@2|Bacteria,2G8IK@200795|Chloroflexi,375EI@32061|Chloroflexia 32061|Chloroflexia M 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - - - - - - - - - - - SRD1_k127_3527766_1 700598.Niako_4032 6.91e-107 351.0 COG0841@1|root,COG0841@2|Bacteria,4NDZG@976|Bacteroidetes,1IPE6@117747|Sphingobacteriia 976|Bacteroidetes V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran SRD1_k127_3529215_5 443144.GM21_4001 1.62e-25 112.0 COG0839@1|root,COG0839@2|Bacteria,1MWJV@1224|Proteobacteria,42V5H@68525|delta/epsilon subdivisions,2WQF4@28221|Deltaproteobacteria,43USM@69541|Desulfuromonadales 28221|Deltaproteobacteria C NADH-ubiquinone/plastoquinone oxidoreductase chain 6 nuoJ-1 - 1.6.5.3 ko:K00339 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q3 SRD1_k127_3529215_4 945713.IALB_1870 9.934e-36 138.0 COG0713@1|root,COG0713@2|Bacteria 2|Bacteria C ATP synthesis coupled electron transport nuoK GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:0098797,GO:0098803,GO:1901135,GO:1901360,GO:1901564,GO:1902494,GO:1990204 1.6.5.3 ko:K00340,ko:K05576 ko00190,ko01100,map00190,map01100 M00144,M00145 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q2 SRD1_k127_3529215_3 945713.IALB_1869 1.976e-37 144.0 COG1009@1|root,COG1009@2|Bacteria 2|Bacteria CP NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit nuoL - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_C,Proton_antipo_M,Proton_antipo_N SRD1_k127_3529215_0 945713.IALB_1869 1.673e-203 645.0 COG1009@1|root,COG1009@2|Bacteria 2|Bacteria CP NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit nuoL - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_C,Proton_antipo_M,Proton_antipo_N SRD1_k127_3529215_1 247490.KSU1_D0316 1.169e-176 567.0 COG1008@1|root,COG1008@2|Bacteria,2IX79@203682|Planctomycetes 203682|Planctomycetes C proton-translocating NADH-quinone oxidoreductase, chain M - - 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q5_N,Proton_antipo_M SRD1_k127_3529215_2 452637.Oter_3299 8.897e-83 285.0 COG1055@1|root,COG1055@2|Bacteria,46S6A@74201|Verrucomicrobia,3K7TN@414999|Opitutae 414999|Opitutae P Putative citrate transport - - - - - - - - - - - - CitMHS_2 SRD1_k127_3529467_1 556261.HMPREF0240_02336 6.548e-25 115.0 COG0407@1|root,COG0407@2|Bacteria,1VPBU@1239|Firmicutes,24IYJ@186801|Clostridia 186801|Clostridia H Uroporphyrinogen decarboxylase (URO-D) - - 4.1.1.37 ko:K01599 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000 - - - URO-D SRD1_k127_3529467_0 545695.TREAZ_2233 1.92e-26 121.0 2ESWM@1|root,33KEZ@2|Bacteria 2|Bacteria S Uroporphyrinogen decarboxylase (URO-D) - - - - - - - - - - - - URO-D SRD1_k127_3556144_5 1408433.JHXV01000001_gene841 4.1e-12 78.0 COG1874@1|root,COG1874@2|Bacteria,4NKTY@976|Bacteroidetes,1IBEY@117743|Flavobacteriia 976|Bacteroidetes G Beta-galactosidase - - - - - - - - - - - - Glyco_hydro_42 SRD1_k127_3556144_1 665571.STHERM_c04320 1.517e-117 390.0 COG0524@1|root,COG0524@2|Bacteria,2J70H@203691|Spirochaetes 203691|Spirochaetes G pfkB family carbohydrate kinase - - 2.7.1.45 ko:K00874 ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200 M00061,M00308,M00631 R01541 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - PfkB SRD1_k127_3556144_4 1191523.MROS_0081 4.195e-21 110.0 COG0737@1|root,COG3291@1|root,COG0737@2|Bacteria,COG3291@2|Bacteria 2|Bacteria S metallopeptidase activity xynX5 - 3.2.1.4,3.2.1.8 ko:K01179,ko:K01181 ko00500,ko01100,map00500,map01100 - R06200,R11307,R11308 - ko00000,ko00001,ko01000 - GH5,GH9 - Beta_helix,IgGFc_binding,Metallophos,PKD,SLH SRD1_k127_3556144_3 452637.Oter_3105 1.833e-50 185.0 COG2020@1|root,COG2020@2|Bacteria,46WMG@74201|Verrucomicrobia 74201|Verrucomicrobia O Isoprenylcysteine carboxyl methyltransferase (ICMT) family - - - - - - - - - - - - PEMT SRD1_k127_3556144_2 1121912.AUHD01000002_gene3308 3.082e-95 315.0 COG2367@1|root,COG2367@2|Bacteria 2|Bacteria V Beta-lactamase - - 3.5.2.6 ko:K17836 ko00311,ko01130,ko01501,map00311,map01130,map01501 M00627,M00628 R06363 RC01499 ko00000,ko00001,ko00002,ko01000,ko01504 - - - Beta-lactamase2 SRD1_k127_3561798_1 945713.IALB_1080 3.11e-124 405.0 COG0436@1|root,COG0436@2|Bacteria 2|Bacteria E Aminotransferase - - 2.6.1.1 ko:K00812 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 SRD1_k127_3561798_0 945713.IALB_1079 3.509e-239 750.0 COG1866@1|root,COG1866@2|Bacteria 2|Bacteria H phosphoenolpyruvate carboxykinase (ATP) activity pckA GO:0003674,GO:0003824,GO:0004611,GO:0004612,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0008150,GO:0008152,GO:0009058,GO:0016051,GO:0016829,GO:0016830,GO:0016831,GO:0019318,GO:0019319,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0071704,GO:1901576 4.1.1.49 ko:K01610 ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200 M00003,M00170 R00341 RC00002,RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPCK_ATP SRD1_k127_3561798_2 335543.Sfum_0937 3.426e-85 292.0 COG0204@1|root,COG0204@2|Bacteria,1MY51@1224|Proteobacteria,42QIX@68525|delta/epsilon subdivisions,2WJHE@28221|Deltaproteobacteria 28221|Deltaproteobacteria I Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family - - 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase SRD1_k127_3561798_3 1121930.AQXG01000001_gene1271 9.978e-40 153.0 COG3118@1|root,COG3118@2|Bacteria,4NQ5B@976|Bacteroidetes,1ISZS@117747|Sphingobacteriia 976|Bacteroidetes O Belongs to the thioredoxin family trxA - - ko:K03671 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko03110 - - - Thioredoxin SRD1_k127_3567756_3 86416.Clopa_2015 1.436e-05 49.0 COG1007@1|root,COG1007@2|Bacteria,1TR55@1239|Firmicutes,25ED8@186801|Clostridia,36HX0@31979|Clostridiaceae 186801|Clostridia C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoN - 1.6.5.3 ko:K00343 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M SRD1_k127_3567756_0 429009.Adeg_1759 5.307e-112 380.0 COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1TNZE@1239|Firmicutes,2480H@186801|Clostridia,42EWB@68295|Thermoanaerobacterales 186801|Clostridia H Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration nnrD - 4.2.1.136,5.1.99.6 ko:K17758,ko:K17759 - - - - ko00000,ko01000 - - - ACPS,Carb_kinase,YjeF_N SRD1_k127_3567756_2 1121920.AUAU01000005_gene1088 4.201e-11 71.0 COG2908@1|root,COG5652@1|root,COG2908@2|Bacteria,COG5652@2|Bacteria 2|Bacteria M Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell - - 3.6.1.54 ko:K03269 ko00540,ko01100,map00540,map01100 M00060 R04549 RC00002 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Metallophos,Metallophos_2,VanZ SRD1_k127_3567756_1 1519464.HY22_01855 1.314e-73 252.0 COG0343@1|root,COG0343@2|Bacteria,1FDBR@1090|Chlorobi 1090|Chlorobi J Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) tgt - 2.4.2.29 ko:K00773 - - R03789,R10209 RC00063 ko00000,ko01000,ko03016 - - - TGT SRD1_k127_3569278_1 1380355.JNIJ01000023_gene2432 9.76e-17 79.0 2DP0W@1|root,3302Q@2|Bacteria,1N8JI@1224|Proteobacteria,2UFZ5@28211|Alphaproteobacteria,3K0KH@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Protein of unknown function (DUF2945) - - - - - - - - - - - - DUF2945 SRD1_k127_3569278_0 1443665.JACA01000065_gene4015 1.27e-26 117.0 COG1040@1|root,COG1040@2|Bacteria 2|Bacteria K competence protein comFC - - ko:K02242 - M00429 - - ko00000,ko00002,ko02044 - - - DZR,Pribosyltran SRD1_k127_3576677_2 1191523.MROS_2370 3.885e-207 658.0 COG1008@1|root,COG1008@2|Bacteria 2|Bacteria C NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoM2 - 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q5_N,Proton_antipo_M SRD1_k127_3576677_3 1191523.MROS_2369 3.58e-140 461.0 COG1007@1|root,COG1007@2|Bacteria 2|Bacteria C ATP synthesis coupled electron transport nuoN GO:0003674,GO:0003824,GO:0003954,GO:0008137,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 ko:K00343 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M SRD1_k127_3576677_4 671143.DAMO_0664 3.494e-69 243.0 COG1521@1|root,COG1521@2|Bacteria,2NP3Z@2323|unclassified Bacteria 2|Bacteria K Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis coaX GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.7.1.33 ko:K03525 ko00770,ko01100,map00770,map01100 M00120 R02971,R03018,R04391 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_1986 Pan_kinase SRD1_k127_3576677_5 1297581.H919_01775 8.329e-54 199.0 COG0340@1|root,COG1654@1|root,COG0340@2|Bacteria,COG1654@2|Bacteria,1TQCU@1239|Firmicutes,4HB60@91061|Bacilli,21WEF@150247|Anoxybacillus 91061|Bacilli HK Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor birA - 6.3.4.15 ko:K03524 ko00780,ko01100,map00780,map01100 - R01074,R05145 RC00043,RC00070,RC00096,RC02896 ko00000,ko00001,ko01000,ko03000 - - - BPL_C,BPL_LplA_LipB,HTH_11 SRD1_k127_3576677_1 945713.IALB_1911 1.416e-306 951.0 COG0443@1|root,COG0443@2|Bacteria 2|Bacteria O unfolded protein binding dnaK GO:0000166,GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008144,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010556,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0016989,GO:0017076,GO:0017111,GO:0018995,GO:0019219,GO:0019222,GO:0020003,GO:0022607,GO:0030430,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0033643,GO:0033646,GO:0033655,GO:0034620,GO:0035639,GO:0035966,GO:0035967,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043230,GO:0043531,GO:0043656,GO:0043657,GO:0043933,GO:0044085,GO:0044183,GO:0044215,GO:0044216,GO:0044217,GO:0044421,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0065010,GO:0070887,GO:0071310,GO:0071840,GO:0071944,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1903506,GO:2001141 - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 SRD1_k127_3576677_0 880073.Calab_2983 0.0 1111.0 COG0542@1|root,COG0542@2|Bacteria,2NNNE@2323|unclassified Bacteria 2|Bacteria O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006508,GO:0006807,GO:0006950,GO:0006986,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009266,GO:0009408,GO:0009628,GO:0010033,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030312,GO:0030554,GO:0031249,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0035966,GO:0036094,GO:0040007,GO:0042221,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564 - ko:K03694,ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N SRD1_k127_3576677_6 1122137.AQXF01000002_gene393 1.153e-05 49.0 COG0144@1|root,COG0144@2|Bacteria,1MV2Q@1224|Proteobacteria,2TS6U@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family sun1 - 2.1.1.176 ko:K03500 - - - - ko00000,ko01000,ko03009 - - - Methyltr_RsmB-F SRD1_k127_3589903_5 29760.VIT_19s0015g00650.t01 1.499e-32 129.0 COG0144@1|root,KOG1122@2759|Eukaryota,37M5F@33090|Viridiplantae,3GFZD@35493|Streptophyta 35493|Streptophyta A Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family - GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009383,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.176 ko:K03500 - - - - ko00000,ko01000,ko03009 - - - Methyltr_RsmB-F,NusB SRD1_k127_3589903_0 1379698.RBG1_1C00001G0727 5.527e-165 528.0 COG0156@1|root,COG0156@2|Bacteria,2NNQ7@2323|unclassified Bacteria 2|Bacteria H Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA kbl GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008710,GO:0008890,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0016874,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.3.1.29,2.3.1.47 ko:K00639,ko:K00652 ko00260,ko00780,ko01100,map00260,map00780,map01100 M00123,M00573,M00577 R00371,R03210,R10124 RC00004,RC00039,RC00394,RC02725 ko00000,ko00001,ko00002,ko01000,ko01007 - - iECW_1372.ECW_m3896,iEKO11_1354.EKO11_0103,iPC815.YPO0059,iWFL_1372.ECW_m3896 Aminotran_1_2 SRD1_k127_3589903_1 1382356.JQMP01000003_gene1909 6.153e-121 398.0 COG0489@1|root,COG0489@2|Bacteria,2G60P@200795|Chloroflexi,27XJW@189775|Thermomicrobia 189775|Thermomicrobia D Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP - - - ko:K03593 - - - - ko00000,ko03029,ko03036 - - - FeS_assembly_P,ParA SRD1_k127_3589903_6 1191523.MROS_1844 1.089e-22 99.0 COG0694@1|root,COG0694@2|Bacteria 2|Bacteria O iron-sulfur cluster assembly nfuA - - - - - - - - - - - NifU SRD1_k127_3589903_2 76114.ebA2553 4.38e-76 263.0 2CCV8@1|root,2Z7KX@2|Bacteria,1MY2J@1224|Proteobacteria,2VQKP@28216|Betaproteobacteria,2KY0X@206389|Rhodocyclales 206389|Rhodocyclales S EcsC protein family - - - - - - - - - - - - EcsC SRD1_k127_3589903_4 290512.Paes_0717 1.435e-63 226.0 COG2884@1|root,COG2884@2|Bacteria,1FDYV@1090|Chlorobi 1090|Chlorobi D PFAM ABC transporter related - - - ko:K09812 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - ABC_tran SRD1_k127_3589903_3 518766.Rmar_1652 1.925e-73 260.0 COG1995@1|root,COG1995@2|Bacteria,4NEUR@976|Bacteroidetes,1FIZN@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes H Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) pdxA - 1.1.1.262 ko:K00097 ko00750,ko01100,map00750,map01100 M00124 R05681,R05837,R07406 RC00089,RC00675,RC01475 ko00000,ko00001,ko00002,ko01000 - - - PdxA SRD1_k127_3595097_0 395493.BegalDRAFT_2888 1.17e-222 694.0 COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,1RMYX@1236|Gammaproteobacteria,45ZSW@72273|Thiotrichales 72273|Thiotrichales J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis tuf - - ko:K02358 - - - - ko00000,ko03012,ko03029,ko04147 - - - GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 SRD1_k127_3595097_1 765910.MARPU_09040 8.489e-81 276.0 COG1187@1|root,COG1187@2|Bacteria,1MUCE@1224|Proteobacteria,1RQU0@1236|Gammaproteobacteria,1WW93@135613|Chromatiales 135613|Chromatiales J Belongs to the pseudouridine synthase RsuA family - - 5.4.99.22 ko:K06178 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 SRD1_k127_3595097_2 1384056.N787_04070 4.786e-77 259.0 COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,1RN6J@1236|Gammaproteobacteria,1X393@135614|Xanthomonadales 135614|Xanthomonadales E Belongs to the cysteine synthase cystathionine beta- synthase family - - 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - - PALP SRD1_k127_3602875_3 1123248.KB893338_gene2306 6.257e-23 102.0 COG0577@1|root,COG0577@2|Bacteria,4NDUK@976|Bacteroidetes,1IRGG@117747|Sphingobacteriia 976|Bacteroidetes V MacB-like periplasmic core domain - - - - - - - - - - - - FtsX,MacB_PCD SRD1_k127_3602875_0 1047013.AQSP01000095_gene2303 1.826e-167 557.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD SRD1_k127_3602875_1 1121930.AQXG01000008_gene207 1.405e-111 368.0 COG1136@1|root,COG1136@2|Bacteria,4NFDW@976|Bacteroidetes,1INQS@117747|Sphingobacteriia 976|Bacteroidetes V ABC transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran SRD1_k127_3602875_2 1047013.AQSP01000134_gene1347 1.579e-57 213.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD SRD1_k127_3604859_1 880073.Calab_3803 1.26e-06 54.0 COG2067@1|root,COG2067@2|Bacteria 2|Bacteria I long-chain fatty acid transporting porin activity - - - - - - - - - - - - - SRD1_k127_3604859_0 880073.Calab_1777 1.588e-32 145.0 COG1404@1|root,COG1404@2|Bacteria 2|Bacteria O Belongs to the peptidase S8 family - - 3.2.1.99 ko:K06113,ko:K12685 - - - - ko00000,ko01000,ko02000,ko02044 1.B.12.5.1,1.B.12.5.3 GH43 - Cu_amine_oxidN1,Peptidase_S8,SLH SRD1_k127_3610200_2 1191523.MROS_1693 6.513e-41 163.0 COG2730@1|root,COG2730@2|Bacteria 2|Bacteria G polysaccharide catabolic process - - 3.2.1.4 ko:K01179 ko00500,ko01100,map00500,map01100 - R06200,R11307,R11308 - ko00000,ko00001,ko01000 - GH5,GH9 - CBM60,CBM_4_9,CBM_6,Cellulase,F5_F8_type_C SRD1_k127_3610200_3 1519464.HY22_04650 2.036e-19 99.0 COG3210@1|root,COG4447@1|root,COG3210@2|Bacteria,COG4447@2|Bacteria 2|Bacteria S cellulose binding - - 3.2.1.4 ko:K01179,ko:K21449 ko00500,ko01100,map00500,map01100 - R06200,R11307,R11308 - ko00000,ko00001,ko01000,ko02000 1.B.40.2 GH5,GH9 - Autotransporter,Haemagg_act,PATR,fn3 SRD1_k127_3610200_1 525897.Dbac_1192 1.13e-78 273.0 COG1226@1|root,COG1226@2|Bacteria,1R97G@1224|Proteobacteria,42Y5Z@68525|delta/epsilon subdivisions,2WUMH@28221|Deltaproteobacteria,2METD@213115|Desulfovibrionales 28221|Deltaproteobacteria P Ion transport protein - - - ko:K10716 - - - - ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 - - Ion_trans SRD1_k127_3610200_0 511051.CSE_06690 7.35e-91 302.0 COG0438@1|root,COG0438@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups treT - 2.4.1.245 ko:K13057 ko00500,ko01100,map00500,map01100 - R08946,R10525,R11306 RC00005,RC00049,RC02748 ko00000,ko00001,ko01000 - GT4 - Glycos_transf_1 SRD1_k127_3622193_1 391615.ABSJ01000054_gene1462 1.283e-11 68.0 COG1562@1|root,COG1562@2|Bacteria,1N6J2@1224|Proteobacteria,1S3EY@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Squalene/phytoene synthase - - - - - - - - - - - - SQS_PSY SRD1_k127_3622193_0 880526.KE386488_gene86 3.959e-60 221.0 COG0037@1|root,COG0037@2|Bacteria,4NEJS@976|Bacteroidetes,2FP2A@200643|Bacteroidia,22UBX@171550|Rikenellaceae 976|Bacteroidetes D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine tilS - 6.3.4.19 ko:K04075 - - R09597 RC02633,RC02634 ko00000,ko01000,ko03016 - - - ATP_bind_3,TilS_C SRD1_k127_3644831_0 153721.MYP_4436 4.799e-197 626.0 COG0841@1|root,COG0841@2|Bacteria,4NDZG@976|Bacteroidetes,47K8C@768503|Cytophagia 976|Bacteroidetes V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family bepE_4 - - ko:K03296,ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran SRD1_k127_3644831_1 1185876.BN8_04701 2.393e-188 599.0 COG0500@1|root,COG1215@1|root,COG1215@2|Bacteria,COG2226@2|Bacteria,4NJWI@976|Bacteroidetes,47KMN@768503|Cytophagia 976|Bacteroidetes MQ Glycosyltransferase like family 2 - - - - - - - - - - - - Glycos_transf_2,Methyltransf_23 SRD1_k127_3708581_0 273075.Ta0342 5.515e-06 58.0 COG3387@1|root,arCOG03285@2157|Archaea,2XUZ8@28890|Euryarchaeota,2422X@183967|Thermoplasmata 183967|Thermoplasmata G Glycosyl hydrolases family 15 - - - - - - - - - - - - Glyco_hydro_15 SRD1_k127_3720029_1 1519464.HY22_14260 1.058e-73 254.0 COG1428@1|root,COG1428@2|Bacteria,1FF6T@1090|Chlorobi 1090|Chlorobi F Deoxynucleoside kinase - - - - - - - - - - - - dNK SRD1_k127_3720029_2 1089553.Tph_c26740 5.497e-39 152.0 COG0801@1|root,COG0801@2|Bacteria,1V6PR@1239|Firmicutes,249YP@186801|Clostridia,42GWU@68295|Thermoanaerobacterales 186801|Clostridia H PFAM 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK folK - 2.7.6.3,4.1.2.25 ko:K00950,ko:K13940 ko00790,ko01100,map00790,map01100 M00126,M00841 R03503,R03504 RC00002,RC00017,RC00721,RC00943 ko00000,ko00001,ko00002,ko01000 - - - FolB,HPPK SRD1_k127_3720029_3 1191523.MROS_0144 7.886e-30 122.0 COG1539@1|root,COG1539@2|Bacteria 2|Bacteria H Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin folB - 1.13.11.81,4.1.2.25,5.1.99.8 ko:K01633 ko00790,ko01100,map00790,map01100 M00126,M00840 R03504,R11037,R11073 RC00721,RC00943,RC01479,RC03333,RC03334 ko00000,ko00001,ko00002,ko01000 - - - FolB SRD1_k127_3720029_0 1125863.JAFN01000001_gene1578 1.201e-88 296.0 COG0008@1|root,COG0008@2|Bacteria,1MUC8@1224|Proteobacteria,42MAX@68525|delta/epsilon subdivisions,2WJ5B@28221|Deltaproteobacteria 28221|Deltaproteobacteria J PFAM Glutamyl glutaminyl-tRNA synthetase, class Ic, catalytic glnS - 6.1.1.18 ko:K01886 ko00970,ko01100,map00970,map01100 M00359,M00360 R03652 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - GatB_Yqey,tRNA-synt_1c,tRNA-synt_1c_C SRD1_k127_3737019_2 1191523.MROS_1459 2.608e-85 288.0 COG0484@1|root,COG0484@2|Bacteria 2|Bacteria O heat shock protein binding dnaJ GO:0000988,GO:0000989,GO:0003674,GO:0003756,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006457,GO:0006458,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010556,GO:0015035,GO:0015036,GO:0016020,GO:0016032,GO:0016043,GO:0016491,GO:0016667,GO:0016853,GO:0016860,GO:0016864,GO:0016989,GO:0019219,GO:0019222,GO:0022607,GO:0031323,GO:0031326,GO:0032991,GO:0034641,GO:0034645,GO:0042026,GO:0043167,GO:0043169,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051704,GO:0055114,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0140096,GO:0140110,GO:1901360,GO:1901576,GO:1903506,GO:2001141 - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG SRD1_k127_3737019_3 945713.IALB_1090 4.43e-37 149.0 COG0576@1|root,COG0576@2|Bacteria 2|Bacteria O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ grpE GO:0000166,GO:0000774,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0017076,GO:0030234,GO:0030312,GO:0030554,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0036094,GO:0040007,GO:0042594,GO:0044464,GO:0050790,GO:0050896,GO:0051082,GO:0051716,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0071496,GO:0071944,GO:0097159,GO:0098772,GO:1901265,GO:1901363 - ko:K02652,ko:K03687 - - - - ko00000,ko02035,ko02044,ko03029,ko03110 3.A.15.2 - - GrpE SRD1_k127_3737019_1 1519464.HY22_12070 2.064e-103 347.0 COG1420@1|root,COG1420@2|Bacteria,1FDKF@1090|Chlorobi 1090|Chlorobi K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons hrcA - - ko:K03705 - - - - ko00000,ko03000 - - - HrcA,HrcA_DNA-bdg SRD1_k127_3737019_0 1191523.MROS_1725 5.256e-173 561.0 COG1530@1|root,COG1530@2|Bacteria 2|Bacteria J ribonuclease E activity rng - 3.1.26.12 ko:K08300,ko:K08301 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 SRD1_k127_3798118_3 439235.Dalk_2440 4.906e-42 158.0 COG0179@1|root,COG0179@2|Bacteria,1MUPF@1224|Proteobacteria,42NS5@68525|delta/epsilon subdivisions,2WNQ5@28221|Deltaproteobacteria,2MJ7B@213118|Desulfobacterales 28221|Deltaproteobacteria Q PFAM fumarylacetoacetate (FAA) hydrolase - - - - - - - - - - - - FAA_hydrolase SRD1_k127_3798118_0 1267535.KB906767_gene335 1.643e-209 657.0 COG3508@1|root,COG3508@2|Bacteria,3Y38R@57723|Acidobacteria 57723|Acidobacteria Q Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate hmgA - 1.13.11.5 ko:K00451 ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120 M00044 R02519 RC00737 ko00000,ko00001,ko00002,ko01000 - - - HgmA SRD1_k127_3798118_2 240015.ACP_1626 4.719e-70 242.0 COG1853@1|root,COG1853@2|Bacteria,3Y51K@57723|Acidobacteria,2JMFE@204432|Acidobacteriia 204432|Acidobacteriia S Flavin reductase like domain - - - - - - - - - - - - Flavin_Reduct SRD1_k127_3798118_1 1121930.AQXG01000009_gene293 5.473e-148 482.0 COG0318@1|root,COG0318@2|Bacteria,4NFPF@976|Bacteroidetes,1IXIF@117747|Sphingobacteriia 976|Bacteroidetes IQ AMP-binding enzyme C-terminal domain - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C SRD1_k127_3798638_12 648996.Theam_0711 4.555e-10 64.0 COG1917@1|root,COG1917@2|Bacteria,2G56Q@200783|Aquificae 200783|Aquificae S Cupin domain - - - - - - - - - - - - Cupin_2 SRD1_k127_3798638_2 945713.IALB_2711 1.782e-158 508.0 COG0438@1|root,COG0438@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups bshA GO:0003674,GO:0003824,GO:0016740,GO:0016757 - ko:K00754 - - - - ko00000,ko01000 - GT4 - Glyco_transf_4,Glycos_transf_1 SRD1_k127_3798638_7 518766.Rmar_1989 6.119e-45 172.0 COG1739@1|root,COG1739@2|Bacteria,4NF0D@976|Bacteroidetes,1FJ9B@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S Domain of unknown function (DUF1949) yigZ - - - - - - - - - - - UPF0029 SRD1_k127_3798638_1 945713.IALB_1277 7.843e-178 575.0 COG0282@1|root,COG0282@2|Bacteria 2|Bacteria F acetate kinase activity ackA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.7.2.1 ko:K00925 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00315,R01353 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - iNJ661.Rv0409 Acetate_kinase SRD1_k127_3798638_4 1191523.MROS_1925 1.049e-119 392.0 COG1250@1|root,COG1250@2|Bacteria 2|Bacteria I 3-hydroxyacyl-CoA dehydrogenase hbd2 - 1.1.1.157 ko:K00074 ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120 - R01976,R05576,R06941 RC00029,RC00117 ko00000,ko00001,ko01000 - - - 3HCDH,3HCDH_N SRD1_k127_3798638_10 1123508.JH636441_gene3157 2.136e-13 82.0 COG1277@1|root,COG1277@2|Bacteria,2J0UA@203682|Planctomycetes 203682|Planctomycetes S ABC-2 family transporter protein - - - - - - - - - - - - ABC2_membrane_2 SRD1_k127_3798638_6 1267535.KB906767_gene1462 4.398e-75 263.0 COG1131@1|root,COG1131@2|Bacteria,3Y7J3@57723|Acidobacteria,2JMS8@204432|Acidobacteriia 204432|Acidobacteriia V ABC transporter - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran SRD1_k127_3798638_8 204669.Acid345_0485 2.798e-26 113.0 COG1959@1|root,COG1959@2|Bacteria,3Y4X0@57723|Acidobacteria,2JJEV@204432|Acidobacteriia 204432|Acidobacteriia K Transcriptional regulator - - - - - - - - - - - - Rrf2 SRD1_k127_3798638_5 1210884.HG799464_gene11188 9.807e-117 389.0 COG1104@1|root,COG1104@2|Bacteria,2IXJC@203682|Planctomycetes 203682|Planctomycetes E COG1104 Cysteine sulfinate desulfinase cysteine desulfurase - - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 SRD1_k127_3798638_0 1267535.KB906767_gene4695 1.569e-267 828.0 COG0719@1|root,COG0719@2|Bacteria,3Y2IX@57723|Acidobacteria 57723|Acidobacteria O Uncharacterized protein family (UPF0051) - - - ko:K09014 - - - - ko00000 - - - UPF0051 SRD1_k127_3798638_3 945713.IALB_2894 1.147e-120 391.0 COG0396@1|root,COG0396@2|Bacteria 2|Bacteria O ATPase activity sufC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0044085,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051186,GO:0071840 - ko:K09013 - - - - ko00000,ko02000 - - iECH74115_1262.ECH74115_2396,iECIAI1_1343.ECIAI1_1734,iECIAI39_1322.ECIAI39_1376,iECSP_1301.ECSP_2249,iECs_1301.ECs2389,iEcSMS35_1347.EcSMS35_1514,iG2583_1286.G2583_2077,iSFV_1184.SFV_1705,iSFxv_1172.SFxv_1919,iSSON_1240.SSON_1474,iS_1188.S1844,iZ_1308.Z2710 ABC_tran SRD1_k127_3798638_11 388051.AUFE01000065_gene3874 3.757e-11 67.0 COG0719@1|root,COG0719@2|Bacteria,1MVK0@1224|Proteobacteria,2VMJ9@28216|Betaproteobacteria,1K26K@119060|Burkholderiaceae 28216|Betaproteobacteria O Uncharacterized protein family (UPF0051) sufD - - ko:K09015 - - - - ko00000 - - - UPF0051 SRD1_k127_3803070_6 1267533.KB906733_gene3448 2.945e-10 62.0 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria 2|Bacteria S cAMP biosynthetic process - - - - - - - - - - - - TPR_16,TPR_8 SRD1_k127_3803070_3 697281.Mahau_1339 5.314e-68 244.0 COG0407@1|root,COG0407@2|Bacteria,1V4YU@1239|Firmicutes,24FCZ@186801|Clostridia,42HY1@68295|Thermoanaerobacterales 186801|Clostridia H PFAM Uroporphyrinogen decarboxylase (URO-D) - - 4.1.1.37 ko:K01599 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000 - - - URO-D SRD1_k127_3803070_2 234267.Acid_6173 3.79e-167 529.0 COG1741@1|root,COG1741@2|Bacteria,3Y367@57723|Acidobacteria 57723|Acidobacteria S Pirin C-terminal cupin domain - - - ko:K06911 - - - - ko00000 - - - Pirin,Pirin_C SRD1_k127_3803070_5 75379.Tint_0595 7.223e-15 80.0 2DPTK@1|root,333BS@2|Bacteria,1QVH8@1224|Proteobacteria,2VWD4@28216|Betaproteobacteria,1KP2T@119065|unclassified Burkholderiales 28216|Betaproteobacteria - - - - - - - - - - - - - - YXWGXW SRD1_k127_3803070_4 234267.Acid_2646 1.69e-60 218.0 COG2834@1|root,COG2834@2|Bacteria,3Y7NW@57723|Acidobacteria 57723|Acidobacteria M Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - - - - - - - - - - - SRD1_k127_3803070_0 234267.Acid_2647 0.0 1269.0 COG4409@1|root,COG4447@1|root,COG4409@2|Bacteria,COG4447@2|Bacteria,3Y6ZR@57723|Acidobacteria 57723|Acidobacteria M Sortilin, neurotensin receptor 3, - - - - - - - - - - - - Sortilin-Vps10 SRD1_k127_3803070_1 1173027.Mic7113_5835 2.607e-167 535.0 COG0467@1|root,COG0467@2|Bacteria,1G2R3@1117|Cyanobacteria,1HA0C@1150|Oscillatoriales 1117|Cyanobacteria T in signal transduction - - - ko:K08482 - - - - ko00000 - - - ATPase SRD1_k127_3807080_0 292459.STH2612 2.823e-63 236.0 COG0642@1|root,COG2205@2|Bacteria,1TRAB@1239|Firmicutes,24DV3@186801|Clostridia 186801|Clostridia T Psort location CytoplasmicMembrane, score - - - - - - - - - - - - DUF4173 SRD1_k127_3807080_2 742767.HMPREF9456_01236 1.069e-26 121.0 COG1695@1|root,COG1695@2|Bacteria,4PKEM@976|Bacteroidetes,2G11D@200643|Bacteroidia,23289@171551|Porphyromonadaceae 976|Bacteroidetes K Winged helix DNA-binding domain - - - - - - - - - - - - HTH_34 SRD1_k127_3807080_1 1356852.N008_12735 2.098e-40 157.0 COG3127@1|root,COG3127@2|Bacteria,4NN8S@976|Bacteroidetes,47P7G@768503|Cytophagia 976|Bacteroidetes Q membrane - - - - - - - - - - - - - SRD1_k127_3807080_3 742726.HMPREF9448_02631 1.869e-13 82.0 2DZCE@1|root,32V76@2|Bacteria,4NTEW@976|Bacteroidetes,2FYXA@200643|Bacteroidia,230VF@171551|Porphyromonadaceae 976|Bacteroidetes - - - - - - - - - - - - - - - SRD1_k127_3807080_4 1166018.FAES_3152 6.714e-11 64.0 COG0477@1|root,COG2814@2|Bacteria,4NFRE@976|Bacteroidetes,47M1S@768503|Cytophagia 976|Bacteroidetes EGP Transmembrane secretion effector - - - - - - - - - - - - MFS_1,MFS_3 SRD1_k127_3826061_0 706587.Desti_3021 6.845e-113 384.0 COG2202@1|root,COG2204@1|root,COG3850@1|root,COG4191@1|root,COG2202@2|Bacteria,COG2204@2|Bacteria,COG3850@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIU5@28221|Deltaproteobacteria,2MQZQ@213462|Syntrophobacterales 28221|Deltaproteobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg SRD1_k127_3835425_0 502025.Hoch_5363 2.711e-38 147.0 COG3411@1|root,COG3411@2|Bacteria,1RM68@1224|Proteobacteria,42TUK@68525|delta/epsilon subdivisions,2WQGU@28221|Deltaproteobacteria,2YVQK@29|Myxococcales 28221|Deltaproteobacteria C Ferredoxin - - - - - - - - - - - - - SRD1_k127_3835425_2 1540257.JQMW01000014_gene73 7.971e-06 50.0 COG0633@1|root,COG3894@1|root,COG0633@2|Bacteria,COG3894@2|Bacteria,1TP0H@1239|Firmicutes,247S0@186801|Clostridia,36DDZ@31979|Clostridiaceae 186801|Clostridia C PFAM ferredoxin - - - - - - - - - - - - DUF4445,Fer2 SRD1_k127_3839874_2 1499967.BAYZ01000148_gene1752 9.322e-98 331.0 COG0463@1|root,COG0463@2|Bacteria,2NQWR@2323|unclassified Bacteria 2|Bacteria M Glycosyltransferase like family 2 ykcC - 2.4.1.83 ko:K00721,ko:K20534 ko00510,ko01100,map00510,map01100 - R01009 RC00005 ko00000,ko00001,ko01000,ko01003,ko01005,ko02000 4.D.2.1.9 GT2 - Glycos_transf_2 SRD1_k127_3839874_7 1499967.BAYZ01000061_gene5938 3.606e-41 175.0 COG2755@1|root,COG5617@1|root,COG2755@2|Bacteria,COG5617@2|Bacteria,2NS5H@2323|unclassified Bacteria 2|Bacteria E Bacterial membrane protein YfhO - - - - - - - - - - - - Lipase_GDSL_2,YfhO,cNMP_binding SRD1_k127_3839874_0 1519464.HY22_06390 1.242e-129 424.0 COG0859@1|root,COG0859@2|Bacteria,1FF11@1090|Chlorobi 1090|Chlorobi M Glycosyltransferase family 9 (heptosyltransferase) - - - ko:K02843 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT9 - Glyco_transf_9 SRD1_k127_3839874_1 1191523.MROS_1306 4.138e-118 390.0 COG0463@1|root,COG0463@2|Bacteria 2|Bacteria M Glycosyl transferase, family 2 arnC - 2.4.1.83 ko:K00721 ko00510,ko01100,map00510,map01100 - R01009 RC00005 ko00000,ko00001,ko01000,ko01003 - GT2 - Glycos_transf_2 SRD1_k127_3839874_3 517418.Ctha_1952 2.861e-87 320.0 COG2982@1|root,COG2982@2|Bacteria 2|Bacteria M Protein involved in outer membrane biogenesis - - - ko:K07289,ko:K09800 - - - - ko00000,ko02000 - - - AsmA,AsmA_1,AsmA_2,DUF3971,DctA-YdbH SRD1_k127_3839874_6 1500890.JQNL01000001_gene1295 5.847e-57 217.0 COG0030@1|root,COG0030@2|Bacteria,1MVNU@1224|Proteobacteria,1RMHW@1236|Gammaproteobacteria,1X38K@135614|Xanthomonadales 135614|Xanthomonadales J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits ksgA GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.182 ko:K02528 - - R10716 RC00003,RC03257 ko00000,ko01000,ko03009 - - - RrnaAD SRD1_k127_3839874_4 945713.IALB_2351 9.248e-80 286.0 COG0671@1|root,COG0671@2|Bacteria 2|Bacteria I phosphatidate phosphatase activity - - - - - - - - - - - - PAP2_3 SRD1_k127_3839874_5 688270.Celal_1646 2.212e-59 217.0 COG0657@1|root,COG0657@2|Bacteria,4NGAF@976|Bacteroidetes,1HZ5F@117743|Flavobacteriia,1F8X2@104264|Cellulophaga 976|Bacteroidetes I Protein of unknown function (DUF1460) - - - - - - - - - - - - DUF1460 SRD1_k127_3845780_0 1191523.MROS_1562 1.241e-59 220.0 COG0484@1|root,COG0484@2|Bacteria 2|Bacteria O heat shock protein binding - - - - - - - - - - - - GSu_C4xC__C2xCH SRD1_k127_3845780_1 1191523.MROS_0623 4.237e-18 90.0 COG1138@1|root,COG1138@2|Bacteria 2|Bacteria O Cytochrome C-type biogenesis protein ccmF - - ko:K02198 - - - - ko00000,ko02000 9.B.14.1 - - CcmF_C,Cytochrom_C_asm SRD1_k127_3894504_0 547042.BACCOPRO_00212 1.511e-211 684.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,4NDVA@976|Bacteroidetes,2FM8X@200643|Bacteroidia,4AKN4@815|Bacteroidaceae 976|Bacteroidetes L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 SRD1_k127_3894504_5 880073.Calab_0003 1.435e-39 156.0 COG1983@1|root,COG1983@2|Bacteria,2NQ85@2323|unclassified Bacteria 2|Bacteria KT PspC domain pspC - - - - - - - - - - - PspC SRD1_k127_3894504_4 945713.IALB_0701 2.544e-58 208.0 COG0233@1|root,COG0233@2|Bacteria 2|Bacteria J cytoplasmic translational termination frr GO:0002181,GO:0002184,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0030312,GO:0032984,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02838 - - - - ko00000,ko03012 - - - RRF SRD1_k127_3894504_2 517418.Ctha_0527 1.354e-100 333.0 COG0528@1|root,COG0528@2|Bacteria,1FD6T@1090|Chlorobi 1090|Chlorobi F Catalyzes the reversible phosphorylation of UMP to UDP pyrH - 2.7.4.22 ko:K09903 ko00240,ko01100,map00240,map01100 - R00158 RC00002 ko00000,ko00001,ko01000 - - - AA_kinase SRD1_k127_3894504_3 518766.Rmar_0008 1.867e-84 288.0 COG0264@1|root,COG0264@2|Bacteria,4NF03@976|Bacteroidetes,1FIR9@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome tsf GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02357 - - - - ko00000,ko03012,ko03029 - - - EF_TS SRD1_k127_3894504_1 945713.IALB_0698 7.883e-101 334.0 COG0052@1|root,COG0052@2|Bacteria 2|Bacteria J Belongs to the universal ribosomal protein uS2 family rpsB GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02967 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S2 SRD1_k127_3905804_1 945713.IALB_3151 4.568e-132 452.0 COG2091@1|root,COG2091@2|Bacteria 2|Bacteria H lysine biosynthetic process via aminoadipic acid - - - - - - - - - - - - ACPS,CBM9_1 SRD1_k127_3905804_0 234267.Acid_4487 9.396e-214 693.0 COG1132@1|root,COG1132@2|Bacteria 2|Bacteria V (ABC) transporter - - - ko:K06147,ko:K06148 - - - - ko00000,ko02000 3.A.1,3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran SRD1_k127_3905804_2 1349785.BAUG01000018_gene1287 3.308e-15 79.0 COG1073@1|root,COG1073@2|Bacteria,4NFCA@976|Bacteroidetes,1HXRJ@117743|Flavobacteriia 976|Bacteroidetes S PS-10 peptidase S37 - - - - - - - - - - - - Peptidase_S37 SRD1_k127_3911062_0 338963.Pcar_1282 3.322e-50 183.0 COG0615@1|root,COG2870@1|root,COG0615@2|Bacteria,COG2870@2|Bacteria,1MV3Z@1224|Proteobacteria,42MBC@68525|delta/epsilon subdivisions,2WIKU@28221|Deltaproteobacteria,43TN4@69541|Desulfuromonadales 28221|Deltaproteobacteria F Catalyzes the phosphorylation of D-glycero-D-manno- heptose 7-phosphate at the C-1 position to selectively form D- glycero-beta-D-manno-heptose-1,7-bisphosphate hldE GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008713,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016757,GO:0016772,GO:0019200,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0046835,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.7.1.167,2.7.7.70 ko:K03272 ko00540,ko01100,map00540,map01100 M00064 R05644,R05646 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko01005 - - iAF987.Gmet_0922 CTP_transf_like,PfkB SRD1_k127_3911062_1 927658.AJUM01000040_gene898 1.874e-11 76.0 COG2911@1|root,COG2911@2|Bacteria,4NSGX@976|Bacteroidetes,2FWBM@200643|Bacteroidia,3XJUG@558415|Marinilabiliaceae 976|Bacteroidetes S TamB, inner membrane protein subunit of TAM complex - - - ko:K09800 - - - - ko00000,ko02000 - - - AsmA,TamB SRD1_k127_3925552_6 1236514.BAKL01000011_gene1292 2.303e-09 67.0 COG3408@1|root,COG3408@2|Bacteria,4NF09@976|Bacteroidetes,2FQZM@200643|Bacteroidia,4AMWC@815|Bacteroidaceae 976|Bacteroidetes G Amylo-alpha-1,6-glucosidase - - - - - - - - - - - - GDE_C,GDE_N SRD1_k127_3925552_5 1121015.N789_13515 4.576e-16 87.0 COG0745@1|root,COG0745@2|Bacteria,1N0YI@1224|Proteobacteria,1RMWT@1236|Gammaproteobacteria,1X2XT@135614|Xanthomonadales 135614|Xanthomonadales KT Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain phoP - - ko:K07660 ko01503,ko02020,map01503,map02020 M00444,M00709,M00721,M00723,M00724,M00744 - - ko00000,ko00001,ko00002,ko01504,ko02022 - - - Response_reg,Trans_reg_C SRD1_k127_3925552_0 1191523.MROS_1971 1.169e-68 237.0 COG0432@1|root,COG0432@2|Bacteria 2|Bacteria S Uncharacterised protein family UPF0047 - - - - - - - - - - - - UPF0047 SRD1_k127_3925552_2 1191523.MROS_0283 3.014e-63 235.0 COG4219@1|root,COG4219@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - Amidase_6,DUF4309,DUF5301 SRD1_k127_3925552_3 945713.IALB_0761 1.115e-45 177.0 COG1560@1|root,COG1560@2|Bacteria 2|Bacteria M Kdo2-lipid A biosynthetic process htrB - 2.3.1.241 ko:K02517 ko00540,ko01100,map00540,map01100 M00060 R05146 RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Lip_A_acyltrans SRD1_k127_3925552_1 1379698.RBG1_1C00001G1513 2.17e-68 246.0 COG0859@1|root,COG0859@2|Bacteria,2NP5P@2323|unclassified Bacteria 2|Bacteria M Glycosyl transferase, family 9 - - - ko:K02843 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT9 - Glyco_transf_9 SRD1_k127_3925552_4 671143.DAMO_1393 3.836e-30 126.0 COG0009@1|root,COG0009@2|Bacteria,2NPMH@2323|unclassified Bacteria 2|Bacteria J Belongs to the SUA5 family prmC - 2.7.7.87 ko:K07566 - - R10463 RC00745 ko00000,ko01000,ko03009,ko03016 - - - SUA5,Sua5_yciO_yrdC SRD1_k127_3935579_1 748449.Halha_1324 8.289e-43 172.0 COG0477@1|root,COG2814@2|Bacteria,1UMZ7@1239|Firmicutes,25GST@186801|Clostridia 186801|Clostridia EGP Arabinose efflux permease family protein - - - - - - - - - - - - MFS_1 SRD1_k127_3935579_0 1536775.H70737_15025 4.611e-135 456.0 COG1874@1|root,COG1874@2|Bacteria,1U3F2@1239|Firmicutes,4IC6E@91061|Bacilli,271AT@186822|Paenibacillaceae 91061|Bacilli G Glycosyl hydrolases family 35 - - 3.2.1.23 ko:K12308 ko00052,map00052 - R01105 RC00452 ko00000,ko00001,ko01000 - - - Glyco_hydro_42,Glyco_hydro_42M SRD1_k127_396175_1 1123508.JH636449_gene7331 5.313e-63 225.0 COG2120@1|root,COG2120@2|Bacteria,2IYPC@203682|Planctomycetes 203682|Planctomycetes S LmbE homologs - - - - - - - - - - - - PIG-L SRD1_k127_396175_0 1122605.KB893625_gene1710 4.216e-72 267.0 COG1572@1|root,COG1572@2|Bacteria,4NT56@976|Bacteroidetes,1IZ9N@117747|Sphingobacteriia 976|Bacteroidetes S Domain of unknown function (DUF4091) - - - - - - - - - - - - DUF4091 SRD1_k127_396175_3 1303518.CCALI_02545 8.839e-15 85.0 COG5434@1|root,COG5434@2|Bacteria 2|Bacteria M polygalacturonase activity - - - - - - - - - - - - Glyco_hydro_28,Pectate_lyase_3 SRD1_k127_3967931_2 517418.Ctha_1205 6.127e-84 284.0 COG0075@1|root,COG0075@2|Bacteria,1FEKT@1090|Chlorobi 1090|Chlorobi H PFAM aminotransferase class V - - - - - - - - - - - - Aminotran_5 SRD1_k127_3967931_4 1395587.P364_0130455 8.541e-54 198.0 COG0218@1|root,COG0218@2|Bacteria,1TSPW@1239|Firmicutes,4HBXZ@91061|Bacilli,26RHP@186822|Paenibacillaceae 91061|Bacilli D Necessary for normal cell division and for the maintenance of normal septation engB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K03978 - - - - ko00000,ko03036 - - - MMR_HSR1 SRD1_k127_3967931_6 1191523.MROS_0188 1.696e-33 135.0 COG0203@1|root,COG0203@2|Bacteria 2|Bacteria J mitochondrial genome maintenance rplQ GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02879,ko:K16193 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L17 SRD1_k127_3967931_0 945713.IALB_0939 7.929e-131 426.0 COG0202@1|root,COG0202@2|Bacteria 2|Bacteria K RNA polymerase activity rpoA GO:0003674,GO:0003824,GO:0003899,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 ko:K03040 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L SRD1_k127_3967931_1 945713.IALB_0938 1.297e-93 311.0 COG0522@1|root,COG0522@2|Bacteria 2|Bacteria J rRNA binding rpsD GO:0000028,GO:0000900,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006355,GO:0006412,GO:0006417,GO:0006446,GO:0006450,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010608,GO:0010628,GO:0010629,GO:0015935,GO:0016043,GO:0017148,GO:0019219,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030371,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031554,GO:0031564,GO:0032268,GO:0032269,GO:0032270,GO:0032991,GO:0034248,GO:0034249,GO:0034250,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043244,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045182,GO:0045727,GO:0045903,GO:0045947,GO:0048027,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051172,GO:0051173,GO:0051246,GO:0051247,GO:0051248,GO:0051252,GO:0060255,GO:0065003,GO:0065007,GO:0065008,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0090079,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:1990145,GO:1990904,GO:2000112,GO:2000113,GO:2001141 - ko:K02986 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S4,S4 SRD1_k127_3967931_3 945713.IALB_0937 7.041e-57 204.0 COG0100@1|root,COG0100@2|Bacteria 2|Bacteria J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome rpsK GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02948 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S11 SRD1_k127_3967931_5 1191523.MROS_0192 8.4e-53 188.0 COG0099@1|root,COG0099@2|Bacteria 2|Bacteria J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits rpsM GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02952 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S13 SRD1_k127_3971004_2 1321778.HMPREF1982_00035 6.386e-75 269.0 COG2511@1|root,COG2511@2|Bacteria,1UPG0@1239|Firmicutes,25HFT@186801|Clostridia 186801|Clostridia J GatB/GatE catalytic domain - - - - - - - - - - - - GatB_N SRD1_k127_3971004_0 1499683.CCFF01000013_gene324 8.066e-218 688.0 COG0252@1|root,COG0252@2|Bacteria,1TPP9@1239|Firmicutes,248F3@186801|Clostridia,36EB6@31979|Clostridiaceae 186801|Clostridia EJ L-asparaginase - - 3.5.1.1 ko:K01424 ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110 - R00485 RC00010,RC02798 ko00000,ko00001,ko01000 - - - Asparaginase SRD1_k127_3971004_1 351160.RCIX1913 1.219e-90 312.0 COG1852@1|root,arCOG02078@2157|Archaea,2XXPW@28890|Euryarchaeota 28890|Euryarchaeota S Protein of unknown function DUF116 - - - - - - - - - - - - DUF116 SRD1_k127_3971004_3 880073.Calab_3730 1.084e-66 243.0 COG1940@1|root,COG1940@2|Bacteria,2NPF7@2323|unclassified Bacteria 2|Bacteria GK Sugar kinase of the NBD HSP70 family, may containing an N-terminal HTH domain - - 2.7.1.2 ko:K00845 ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R01600,R01786 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - HTH_24,MarR_2,ROK SRD1_k127_3971004_4 414996.IL38_23285 1.267e-26 115.0 COG3324@1|root,COG3324@2|Bacteria,2GPAS@201174|Actinobacteria 201174|Actinobacteria E translation initiation factor activity - - - ko:K06996 - - - - ko00000 - - - Glyoxalase SRD1_k127_3978028_1 493475.GARC_5358 3.917e-167 548.0 COG3345@1|root,COG3345@2|Bacteria,1MW78@1224|Proteobacteria,1RRKC@1236|Gammaproteobacteria 1236|Gammaproteobacteria G enterotoxin ast - - - - - - - - - - - - SRD1_k127_3978028_0 1499967.BAYZ01000036_gene2415 9.227e-208 656.0 COG0557@1|root,COG0557@2|Bacteria,2NNV2@2323|unclassified Bacteria 2|Bacteria J 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs rnb - 3.1.13.1 ko:K01147,ko:K12573 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03016,ko03019 - - - OB_RNB,RNB,S1 SRD1_k127_3978028_2 1356852.N008_09960 2.011e-14 75.0 2EHJH@1|root,336RS@2|Bacteria,4NX01@976|Bacteroidetes,47SDR@768503|Cytophagia 976|Bacteroidetes - - - - - - - - - - - - - - - SRD1_k127_3985310_4 204536.SULAZ_1122 6.439e-13 77.0 COG2801@1|root,COG2801@2|Bacteria,2G3YF@200783|Aquificae 200783|Aquificae L PFAM Integrase core domain - - - - - - - - - - - - HTH_28,HTH_32,HTH_Tnp_Tc3_2,rve,rve_3 SRD1_k127_3985310_0 1242864.D187_006059 3.247e-91 317.0 COG2271@1|root,COG2271@2|Bacteria,1MX4V@1224|Proteobacteria,42QEQ@68525|delta/epsilon subdivisions,2WQEB@28221|Deltaproteobacteria,2YTVI@29|Myxococcales 28221|Deltaproteobacteria G Major Facilitator Superfamily glp - - ko:K02445 - - - - ko00000,ko02000 2.A.1.4.3 - - MFS_1 SRD1_k127_3985310_3 511051.CSE_10050 2.343e-18 94.0 2BVWN@1|root,33U5I@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - SRD1_k127_3985310_1 459349.CLOAM1796 2.974e-64 243.0 COG0737@1|root,COG0737@2|Bacteria,2NQR9@2323|unclassified Bacteria 2|Bacteria F Belongs to the 5'-nucleotidase family soxB - 3.1.3.5,3.6.1.45 ko:K01081,ko:K11751,ko:K17224 ko00230,ko00240,ko00760,ko00920,ko01100,ko01110,ko01120,map00230,map00240,map00760,map00920,map01100,map01110,map01120 M00595 R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346,R10151 RC00017,RC03151,RC03152 ko00000,ko00001,ko00002,ko01000 - - - 5_nucleotid_C,Metallophos SRD1_k127_3985310_2 207559.Dde_0193 3.311e-63 227.0 COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,42N2G@68525|delta/epsilon subdivisions,2WIXB@28221|Deltaproteobacteria,2M8RR@213115|Desulfovibrionales 28221|Deltaproteobacteria I PFAM AMP-dependent synthetase and ligase - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C,Acyltransferase,PP-binding SRD1_k127_3997358_2 1303518.CCALI_00184 1.812e-26 118.0 COG3420@1|root,COG3420@2|Bacteria 2|Bacteria P alginic acid biosynthetic process galA - - - - - - - - - - - Beta_helix,CBM_4_9,CBM_6,DUF1565 SRD1_k127_3997358_0 665956.HMPREF1032_00853 2.733e-117 387.0 COG0407@1|root,COG0407@2|Bacteria,1V4YU@1239|Firmicutes,24KSS@186801|Clostridia,3WPW7@541000|Ruminococcaceae 186801|Clostridia H Uroporphyrinogen decarboxylase (URO-D) - - - - - - - - - - - - URO-D SRD1_k127_3997358_1 1191523.MROS_2845 4.293e-75 258.0 COG1312@1|root,COG1312@2|Bacteria 2|Bacteria G mannonate dehydratase activity uxuA - 4.2.1.8 ko:K01686 ko00040,ko01100,map00040,map01100 M00061 R05606 RC00543 ko00000,ko00001,ko00002,ko01000 - - - UxuA SRD1_k127_4012112_2 945713.IALB_2294 2.012e-22 101.0 COG1314@1|root,COG1314@2|Bacteria 2|Bacteria U P-P-bond-hydrolysis-driven protein transmembrane transporter activity secG GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0022857,GO:0022884,GO:0031522,GO:0032978,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0042886,GO:0042887,GO:0043952,GO:0044464,GO:0045047,GO:0045184,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680 - ko:K03075 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - SecG SRD1_k127_4012112_1 1519464.HY22_06975 8.749e-56 201.0 COG0307@1|root,COG0307@2|Bacteria,1FDVH@1090|Chlorobi 1090|Chlorobi H TIGRFAM riboflavin synthase, alpha subunit - - 2.5.1.9 ko:K00793 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00066 RC00958,RC00960 ko00000,ko00001,ko00002,ko01000 - - - Lum_binding SRD1_k127_4012112_0 56780.SYN_00578 6.452e-80 281.0 COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1MUWT@1224|Proteobacteria,42NBS@68525|delta/epsilon subdivisions,2WIP2@28221|Deltaproteobacteria,2MQ7J@213462|Syntrophobacterales 28221|Deltaproteobacteria H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate ribD - 1.1.1.193,3.5.4.26 ko:K11752 ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024 M00125 R03458,R03459 RC00204,RC00933 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_1624 RibD_C,dCMP_cyt_deam_1 SRD1_k127_4025257_1 861299.J421_0763 1.7e-79 273.0 COG0612@1|root,COG0612@2|Bacteria 2|Bacteria L Peptidase, M16 - - - - - - - - - - - - Peptidase_M16,Peptidase_M16_C SRD1_k127_4025257_0 234267.Acid_0504 1.861e-185 591.0 COG0612@1|root,COG0612@2|Bacteria 2|Bacteria L Peptidase, M16 - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C SRD1_k127_4025257_2 404589.Anae109_4101 1.043e-53 194.0 COG2227@1|root,COG2227@2|Bacteria,1RIMR@1224|Proteobacteria,43CQM@68525|delta/epsilon subdivisions,2X7Y3@28221|Deltaproteobacteria 28221|Deltaproteobacteria H Mycolic acid cyclopropane synthetase - - - - - - - - - - - - - SRD1_k127_4029409_1 1408473.JHXO01000008_gene2723 7.79e-64 228.0 COG1566@1|root,COG1566@2|Bacteria,4NEQJ@976|Bacteroidetes,2FMKF@200643|Bacteroidia 976|Bacteroidetes V Auxiliary transport protein, membrane fusion protein (MFP) family protein - - - ko:K03543 - M00701 - - ko00000,ko00002,ko02000 8.A.1.1 - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 SRD1_k127_4029409_0 1408473.JHXO01000008_gene2724 6.446e-210 664.0 COG0477@1|root,COG2814@2|Bacteria,4NG27@976|Bacteroidetes,2FNG3@200643|Bacteroidia 976|Bacteroidetes P major facilitator superfamily - - - ko:K03446 - M00701 - - ko00000,ko00002,ko02000 2.A.1.3 - - MFS_1 SRD1_k127_4031077_1 243275.TDE_2472 2.682e-70 254.0 COG2801@1|root,COG2801@2|Bacteria,2JAQ6@203691|Spirochaetes 203691|Spirochaetes L similarity to SP Q54513 - - - - - - - - - - - - HTH_23,rve SRD1_k127_4031077_4 1123278.KB893600_gene2763 1.271e-09 66.0 2CKDD@1|root,339I4@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - SRD1_k127_4031077_5 574375.BAGA_11340 1.184e-05 51.0 COG2076@1|root,COG2076@2|Bacteria,1VEUF@1239|Firmicutes,4HM1T@91061|Bacilli,1ZI26@1386|Bacillus 91061|Bacilli U Small Multidrug Resistance protein ebrA GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944 - ko:K11814 - M00710 - - ko00000,ko00002,ko02000 2.A.7.1.6 - - Multi_Drug_Res SRD1_k127_4031077_2 518766.Rmar_0069 1.433e-67 236.0 COG0564@1|root,COG0564@2|Bacteria,4NHKH@976|Bacteroidetes 976|Bacteroidetes J Pseudouridine synthase - - 5.4.99.23,5.4.99.24 ko:K06179,ko:K06180 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2 SRD1_k127_4031077_3 582744.Msip34_2411 2.372e-45 175.0 COG2905@1|root,COG2905@2|Bacteria,1QTTR@1224|Proteobacteria,2WGT1@28216|Betaproteobacteria,2KMWZ@206350|Nitrosomonadales 206350|Nitrosomonadales T PFAM CBS domain containing protein - - - - - - - - - - - - CBS SRD1_k127_4031077_0 945713.IALB_2620 3.323e-205 666.0 COG1198@1|root,COG1198@2|Bacteria 2|Bacteria L DNA replication, synthesis of RNA primer priA GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 - ko:K04066 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,ResIII SRD1_k127_4032910_3 714943.Mucpa_2551 0.0001164 46.0 2EIUI@1|root,33CJV@2|Bacteria,4NYR6@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - SRD1_k127_4032910_2 1519464.HY22_02950 2.341e-14 83.0 COG0457@1|root,COG0457@2|Bacteria,1FF81@1090|Chlorobi 1090|Chlorobi S Tetratricopeptide repeat - - - - - - - - - - - - - SRD1_k127_4032910_1 1191523.MROS_0324 5.21e-32 129.0 COG0776@1|root,COG0776@2|Bacteria 2|Bacteria L regulation of translation hup_1 - - ko:K03530,ko:K05788 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding SRD1_k127_4032910_0 1379698.RBG1_1C00001G1142 1.057e-67 243.0 COG0616@1|root,COG0616@2|Bacteria,2NPIE@2323|unclassified Bacteria 2|Bacteria OU Peptidase family S49 sppA - - ko:K04773 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S49 SRD1_k127_4035409_3 1283300.ATXB01000001_gene1756 7.244e-13 73.0 COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,1RN3S@1236|Gammaproteobacteria,1XDRB@135618|Methylococcales 135618|Methylococcales E PFAM Aminotransferase - - - - - - - - - - - - Aminotran_5 SRD1_k127_4035409_1 1122176.KB903540_gene40 4.749e-114 384.0 COG0531@1|root,COG0531@2|Bacteria,4NH7J@976|Bacteroidetes,1IPW4@117747|Sphingobacteriia 976|Bacteroidetes E amino acid - - - ko:K03294 - - - - ko00000 2.A.3.2 - - AA_permease_2 SRD1_k127_4035409_2 926549.KI421517_gene665 4.579e-61 222.0 COG4430@1|root,COG4430@2|Bacteria,4NNH0@976|Bacteroidetes,47PYG@768503|Cytophagia 976|Bacteroidetes S Bacteriocin-protection, YdeI or OmpD-Associated - - - - - - - - - - - - DUF1801,OmdA SRD1_k127_4035409_0 1235803.C825_03152 2.586e-306 960.0 COG0383@1|root,COG0383@2|Bacteria,4NGF5@976|Bacteroidetes,2FRK9@200643|Bacteroidia,22Z81@171551|Porphyromonadaceae 976|Bacteroidetes G Glycosyl hydrolases family 38 C-terminal domain - - - - - - - - - - - - Glyco_hydro_38,Glyco_hydro_38C SRD1_k127_4035504_0 517418.Ctha_0233 1.224e-148 498.0 COG4232@1|root,COG4233@1|root,COG4232@2|Bacteria,COG4233@2|Bacteria,1FDRS@1090|Chlorobi 1090|Chlorobi C Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps dsbD - 1.8.1.8 ko:K04084 - - - - ko00000,ko01000,ko03110 5.A.1.1 - - DsbC,DsbD,Thioredoxin_7 SRD1_k127_4035504_2 945713.IALB_1267 9.281e-43 170.0 COG4447@1|root,COG4447@2|Bacteria 2|Bacteria S cellulose binding - - - - - - - - - - - - Cu_amine_oxidN1,PSII_BNR SRD1_k127_4035504_1 1123277.KB893174_gene6067 5.507e-103 346.0 28M5E@1|root,2ZAJ7@2|Bacteria,4NZ10@976|Bacteroidetes,47TH9@768503|Cytophagia 976|Bacteroidetes - - - - - - - - - - - - - - - SRD1_k127_4035672_3 756499.Desde_3729 3.498e-21 94.0 COG1027@1|root,COG1027@2|Bacteria,1TP3U@1239|Firmicutes,2483Z@186801|Clostridia,260SP@186807|Peptococcaceae 186801|Clostridia E Aspartate ammonia-lyase aspA - 4.3.1.1 ko:K01744 ko00250,ko01100,map00250,map01100 - R00490 RC00316,RC02799 ko00000,ko00001,ko01000 - - - FumaraseC_C,Lyase_1 SRD1_k127_4035672_0 1191523.MROS_2214 3.194e-103 364.0 COG1629@1|root,COG1629@2|Bacteria 2|Bacteria P transport - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec SRD1_k127_4035672_1 1519464.HY22_00560 5.559e-64 246.0 COG3292@1|root,COG4447@1|root,COG3292@2|Bacteria,COG4447@2|Bacteria 2|Bacteria S cellulose binding - - - - - - - - - - - - BNR,Reprolysin_5 SRD1_k127_4035672_4 368407.Memar_0884 1.507e-10 66.0 COG0642@1|root,COG2202@1|root,arCOG06192@2157|Archaea,arCOG06918@2157|Archaea 2157|Archaea T Pas domain - - - - - - - - - - - - GAF_2,HATPase_c,PAS,PAS_3,PAS_4,PAS_9,Response_reg SRD1_k127_4035672_2 338963.Pcar_2565 3.565e-45 178.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,42M0W@68525|delta/epsilon subdivisions,2WUAW@28221|Deltaproteobacteria,43U3F@69541|Desulfuromonadales 28221|Deltaproteobacteria T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,PAS_3,Response_reg SRD1_k127_4039730_17 1121930.AQXG01000005_gene601 6.023e-09 57.0 COG1404@1|root,COG1404@2|Bacteria,4NVH2@976|Bacteroidetes,1IURU@117747|Sphingobacteriia 976|Bacteroidetes O Belongs to the peptidase S8 family - - - - - - - - - - - - - SRD1_k127_4039730_14 765952.PUV_26370 5.751e-30 123.0 2E3V1@1|root,32YSA@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - SRD1_k127_4039730_15 1123248.KB893316_gene4621 2.359e-25 115.0 COG1231@1|root,COG1231@2|Bacteria,4NP86@976|Bacteroidetes,1IU73@117747|Sphingobacteriia 976|Bacteroidetes E PFAM amine oxidase - - - - - - - - - - - - Amino_oxidase SRD1_k127_4039730_7 525904.Tter_1596 3.09e-88 295.0 COG3880@1|root,COG3880@2|Bacteria,2NPCX@2323|unclassified Bacteria 2|Bacteria S Cytochrome c7 and related cytochrome c mcsA GO:0003674,GO:0005488,GO:0005507,GO:0006950,GO:0008150,GO:0008270,GO:0010035,GO:0010038,GO:0042221,GO:0043167,GO:0043169,GO:0046686,GO:0046688,GO:0046870,GO:0046872,GO:0046914,GO:0050896,GO:0050897,GO:0097501,GO:1990169,GO:1990170 2.7.14.1 ko:K19405,ko:K19411 - - R11090 RC00002,RC00203 ko00000,ko01000 - - - Cytochrom_CIII,Cytochrome_C7,GSu_C4xC__C2xCH,UVR SRD1_k127_4039730_0 1128421.JAGA01000003_gene2870 0.0 1131.0 COG0243@1|root,COG0437@1|root,COG0243@2|Bacteria,COG0437@2|Bacteria,2NNV6@2323|unclassified Bacteria 2|Bacteria C 4Fe-4S dicluster domain hmeA - - ko:K00184 - - - - ko00000 5.A.3 - - Fer4_7,Molydop_binding SRD1_k127_4039730_3 1128421.JAGA01000003_gene2871 1.935e-214 674.0 COG5557@1|root,COG5557@2|Bacteria,2NNNQ@2323|unclassified Bacteria 2|Bacteria C Polysulphide reductase, NrfD nrfD - - ko:K00185 - - - - ko00000 5.A.3 - - DUF3341,NrfD SRD1_k127_4039730_10 1128421.JAGA01000003_gene2872 2.194e-60 214.0 COG2010@1|root,COG2010@2|Bacteria,2NPSE@2323|unclassified Bacteria 2|Bacteria C Protein of unknown function (DUF3341) - - - - - - - - - - - - DUF3341 SRD1_k127_4039730_12 472759.Nhal_2606 1.226e-54 198.0 COG2010@1|root,COG2010@2|Bacteria,1RHGQ@1224|Proteobacteria,1SP2C@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Cytochrome C oxidase, cbb3-type, subunit III - - - - - - - - - - - - Cytochrome_CBB3 SRD1_k127_4039730_6 1128421.JAGA01000003_gene2874 1.908e-100 342.0 COG4531@1|root,COG4531@2|Bacteria,2NP5Y@2323|unclassified Bacteria 2|Bacteria P ABC-type Zn2 transport system, periplasmic component surface adhesin actF - - - - - - - - - - - - SRD1_k127_4039730_18 1382359.JIAL01000001_gene972 9.989e-07 58.0 2EJZ3@1|root,33DPP@2|Bacteria,3Y5X0@57723|Acidobacteria,2JK3F@204432|Acidobacteriia 204432|Acidobacteriia - - - - - - - - - - - - - - - SRD1_k127_4039730_8 234267.Acid_0496 3.268e-77 267.0 COG1999@1|root,COG1999@2|Bacteria,3Y3XH@57723|Acidobacteria 57723|Acidobacteria S signal sequence binding - - - ko:K07152 - - - - ko00000,ko03029 - - - SCO1-SenC SRD1_k127_4039730_5 1128421.JAGA01000003_gene2877 4.288e-109 362.0 COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,2NNSH@2323|unclassified Bacteria 2|Bacteria C Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) coxB GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009319,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016310,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0034641,GO:0042773,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0055086,GO:0055114,GO:0070069,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:1901135,GO:1901360,GO:1901564,GO:1902494 1.9.3.1 ko:K02275,ko:K17223 ko00190,ko00920,ko01100,ko01120,map00190,map00920,map01100,map01120 M00155,M00595 R00081,R10151 RC00016,RC03151,RC03152 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - COX2,COX2_TM,Cytochrom_C,Cytochrome_CBB3 SRD1_k127_4039730_1 234267.Acid_0498 4.306e-265 825.0 COG0843@1|root,COG0843@2|Bacteria,3Y2X6@57723|Acidobacteria 57723|Acidobacteria C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B - - 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 - - COX1 SRD1_k127_4039730_9 1128421.JAGA01000003_gene2879 4.823e-72 249.0 COG1845@1|root,COG1845@2|Bacteria,2NPIG@2323|unclassified Bacteria 2|Bacteria C cytochrome c oxidase subunit III coxC - 1.9.3.1 ko:K02276 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.4,3.D.4.6 - - COX3 SRD1_k127_4039730_16 1128421.JAGA01000003_gene2880 1.319e-19 95.0 2ASAK@1|root,31HPU@2|Bacteria,2NQ6K@2323|unclassified Bacteria 2|Bacteria S Prokaryotic Cytochrome C oxidase subunit IV - - 1.9.3.1 ko:K02277 ko00190,ko01100,map00190,map01100 M00155 - - ko00000,ko00001,ko00002,ko01000 3.D.4.4 - - COX4_pro SRD1_k127_4039730_11 886293.Sinac_3333 6.685e-57 203.0 COG2193@1|root,COG2193@2|Bacteria,2J19B@203682|Planctomycetes 203682|Planctomycetes P Ferritin-like domain - - 1.16.3.1 ko:K03594 ko00860,map00860 - R00078 RC02758 ko00000,ko00001,ko01000 - - - Ferritin SRD1_k127_4039730_13 1267533.KB906733_gene3450 2.144e-47 177.0 COG3685@1|root,COG3685@2|Bacteria,3Y534@57723|Acidobacteria,2JJHZ@204432|Acidobacteriia 204432|Acidobacteriia S Domain of unknown function (DUF892) - - - - - - - - - - - - DUF892 SRD1_k127_4039730_2 321332.CYB_2529 2.472e-221 702.0 COG0296@1|root,COG0296@2|Bacteria,1G0N3@1117|Cyanobacteria,1GZZS@1129|Synechococcus 1117|Cyanobacteria G 4-alpha-D-((1- 4)-alpha-D-glucano)trehalose trehalohydrolase treZ - 3.2.1.141 ko:K01236 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R09995,R11256 RC00049 ko00000,ko00001,ko00002,ko01000 - CBM48,GH13 - Alpha-amylase,CBM_48,DUF3459 SRD1_k127_4039730_4 118168.MC7420_4022 9.326e-143 465.0 COG3280@1|root,COG3280@2|Bacteria,1G3IR@1117|Cyanobacteria,1H9QJ@1150|Oscillatoriales 1117|Cyanobacteria G Maltooligosyl trehalose synthase treY - 5.4.99.15 ko:K06044 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R01824,R09995 - ko00000,ko00001,ko00002,ko01000 - GH13 - Alpha-amylase SRD1_k127_4046733_0 1519464.HY22_03430 2.151e-169 542.0 COG0297@1|root,COG0297@2|Bacteria,1FDT0@1090|Chlorobi 1090|Chlorobi F Synthesizes alpha-1,4-glucan chains using ADP-glucose glgA - 2.4.1.21 ko:K00703 ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026 M00565 R02421 RC00005 ko00000,ko00001,ko00002,ko01000,ko01003 - GT5 - Glyco_transf_5,Glycos_transf_1 SRD1_k127_4046733_1 404380.Gbem_2506 1.384e-50 190.0 COG0241@1|root,COG0241@2|Bacteria,1RDGR@1224|Proteobacteria,42SCB@68525|delta/epsilon subdivisions,2WPEA@28221|Deltaproteobacteria,43UQ7@69541|Desulfuromonadales 28221|Deltaproteobacteria E TIGRFAM D,D-heptose 1,7-bisphosphate phosphatase gmhB - 3.1.3.82,3.1.3.83 ko:K03273 ko00540,ko01100,map00540,map01100 M00064 R05647,R09771 RC00017 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hydrolase_like SRD1_k127_4048671_1 706587.Desti_1948 2.369e-08 57.0 COG0784@1|root,COG2198@1|root,COG2202@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2202@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria,43BU6@68525|delta/epsilon subdivisions,2X756@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c,HisKA,Hpt,PAS,PAS_4,PAS_8,PAS_9,PocR,Response_reg SRD1_k127_4048671_0 1121033.AUCF01000014_gene1299 3.013e-96 338.0 COG0642@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2TXJ2@28211|Alphaproteobacteria,2JPEA@204441|Rhodospirillales 204441|Rhodospirillales T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,Hpt,PAS,PAS_4,PAS_7,Response_reg SRD1_k127_4048671_3 1254432.SCE1572_05770 1.684e-06 57.0 2A4VM@1|root,30TH8@2|Bacteria,1PDC0@1224|Proteobacteria,435FP@68525|delta/epsilon subdivisions,2WZT7@28221|Deltaproteobacteria,2Z2PV@29|Myxococcales 28221|Deltaproteobacteria S Domain of unknown function (DUF4154) - - - - - - - - - - - - DUF4154 SRD1_k127_4048671_2 980584.AFPB01000059_gene3279 6.065e-08 59.0 COG1629@1|root,COG4771@2|Bacteria,4NF4B@976|Bacteroidetes 976|Bacteroidetes P TonB-dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec SRD1_k127_4051982_5 868131.MSWAN_0473 0.0003525 44.0 COG1011@1|root,arCOG02291@2157|Archaea,2XTX3@28890|Euryarchaeota,23NYH@183925|Methanobacteria 183925|Methanobacteria S PFAM Haloacid dehalogenase-like hydrolase - - - ko:K07025 - - - - ko00000 - - - HAD_2 SRD1_k127_4051982_0 1191523.MROS_0448 5.072e-43 167.0 COG1595@1|root,COG1595@2|Bacteria 2|Bacteria K DNA-templated transcription, initiation sigH GO:0000988,GO:0000990,GO:0003674,GO:0005575,GO:0005618,GO:0005623,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0016987,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0033554,GO:0034605,GO:0043254,GO:0044087,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0051409,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2000142,GO:2001141 - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 SRD1_k127_4051982_1 1191523.MROS_0656 4.96e-29 132.0 28P4Q@1|root,2ZBZV@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - SRD1_k127_4051982_4 1123242.JH636436_gene182 7.289e-14 79.0 COG2319@1|root,COG2319@2|Bacteria,2IWR9@203682|Planctomycetes 203682|Planctomycetes C Planctomycete cytochrome C - - - - - - - - - - - - PD40,PSCyt1,WD40 SRD1_k127_4051982_2 1121405.dsmv_2755 1.239e-25 115.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,42MGZ@68525|delta/epsilon subdivisions,2WIY6@28221|Deltaproteobacteria,2MHSH@213118|Desulfobacterales 28221|Deltaproteobacteria L DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA rhlB - 3.6.4.13 ko:K03732 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03019 - - - DEAD,Helicase_C,R3H SRD1_k127_4053275_1 1191523.MROS_2451 4.254e-82 276.0 COG0332@1|root,COG0332@2|Bacteria 2|Bacteria I beta-ketoacyl-acyl-carrier-protein synthase III activity fabH GO:0003674,GO:0003824,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0033818,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0071704 2.3.1.180 ko:K00648 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00082,M00083 R10707 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACP_syn_III,ACP_syn_III_C SRD1_k127_4053275_0 945713.IALB_1992 3.306e-108 358.0 COG0331@1|root,COG0331@2|Bacteria 2|Bacteria I [acyl-carrier-protein] S-malonyltransferase activity fabD - 2.3.1.39 ko:K00645,ko:K15327,ko:K15329,ko:K15355,ko:K15469 ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212 M00082 R01626,R11671 RC00004,RC00039,RC02727 ko00000,ko00001,ko00002,ko01000,ko01004,ko01008 - - - Acyl_transf_1 SRD1_k127_4053275_4 1191523.MROS_2453 1.237e-39 154.0 COG0727@1|root,COG0727@2|Bacteria 2|Bacteria S metal cluster binding - - - ko:K06940,ko:K18475 - - - - ko00000,ko01000,ko02035 - - - CxxCxxCC SRD1_k127_4053275_2 1519464.HY22_06445 2.509e-78 271.0 COG1028@1|root,COG1028@2|Bacteria,1FDUA@1090|Chlorobi 1090|Chlorobi IQ Short-chain dehydrogenase reductase SDR - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 SRD1_k127_4053275_5 945713.IALB_1989 1.036e-30 123.0 COG0236@1|root,COG0236@2|Bacteria 2|Bacteria IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis acpP GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 - ko:K02078 - - - - ko00000,ko00001 - - - PP-binding SRD1_k127_4053275_3 518766.Rmar_2690 2.168e-41 156.0 COG0304@1|root,COG0304@2|Bacteria,4NEKC@976|Bacteroidetes,1FIY5@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP fabF - 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt SRD1_k127_4064426_0 1280390.CBQR020000151_gene4031 6.775e-06 59.0 COG1807@1|root,COG1807@2|Bacteria,1UYMG@1239|Firmicutes,4HB8M@91061|Bacilli,26ZKF@186822|Paenibacillaceae 91061|Bacilli M Dolichyl-phosphate-mannose-protein mannosyltransferase - - - - - - - - - - - - PMT_2 SRD1_k127_4065052_0 1242864.D187_006073 5.216e-118 383.0 COG0312@1|root,COG0312@2|Bacteria,1MUSK@1224|Proteobacteria,42Y66@68525|delta/epsilon subdivisions,2WU83@28221|Deltaproteobacteria,2YX71@29|Myxococcales 28221|Deltaproteobacteria S Putative modulator of DNA gyrase - - - ko:K03568 - - - - ko00000,ko01002 - - - PmbA_TldD SRD1_k127_4065052_1 1192034.CAP_6732 7.279e-109 367.0 COG0312@1|root,COG0312@2|Bacteria,1RBJZ@1224|Proteobacteria,42YBE@68525|delta/epsilon subdivisions,2WUP7@28221|Deltaproteobacteria,2YZ4Y@29|Myxococcales 28221|Deltaproteobacteria L Putative modulator of DNA gyrase - - - ko:K03592 - - - - ko00000,ko01002 - - - PmbA_TldD SRD1_k127_4065052_3 379066.GAU_0150 7.405e-07 59.0 2FK3G@1|root,34BRK@2|Bacteria,1ZU1V@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Outer membrane protein beta-barrel domain - - - - - - - - - - - - OMP_b-brl SRD1_k127_4065052_2 886377.Murru_3346 4.557e-71 246.0 COG0477@1|root,COG2814@2|Bacteria,4NE09@976|Bacteroidetes,1HY74@117743|Flavobacteriia 976|Bacteroidetes EGP Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family araE - - ko:K02100 - - - - ko00000,ko02000 2.A.1.1.2 - - Sugar_tr SRD1_k127_4067882_2 1227739.Hsw_2707 1.893e-96 323.0 COG1085@1|root,COG1085@2|Bacteria,4NEY9@976|Bacteroidetes,47MHS@768503|Cytophagia 976|Bacteroidetes G Galactose-1-phosphate uridyl transferase, C-terminal domain galT - 2.7.7.12 ko:K00965 ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917 M00362,M00554,M00632 R00955 RC00002 ko00000,ko00001,ko00002,ko01000 - - - GalP_UDP_tr_C,GalP_UDP_transf SRD1_k127_4067882_1 1047013.AQSP01000134_gene1344 2.169e-135 441.0 COG0153@1|root,COG0153@2|Bacteria,2NNYM@2323|unclassified Bacteria 2|Bacteria G Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) galK - 2.7.1.6 ko:K00849 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00554,M00632 R01092 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko04147 - - - GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg SRD1_k127_4067882_3 1191523.MROS_0469 3.197e-13 72.0 2DGR5@1|root,2ZWZN@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - SRD1_k127_4067882_0 1191523.MROS_0470 5.78e-174 550.0 COG0591@1|root,COG0591@2|Bacteria 2|Bacteria E symporter activity sglT - - ko:K03307 - - - - ko00000 2.A.21 - - SSF SRD1_k127_4070448_2 1122605.KB893645_gene1191 8.18e-29 122.0 COG3391@1|root,COG3391@2|Bacteria,4NER2@976|Bacteroidetes,1IQ4S@117747|Sphingobacteriia 976|Bacteroidetes M 40-residue YVTN family beta-propeller repeat - - - - - - - - - - - - Lactonase,Phosphoesterase SRD1_k127_4070448_1 1237149.C900_03160 1.82e-44 167.0 COG1714@1|root,COG1714@2|Bacteria,4NW7J@976|Bacteroidetes,47X24@768503|Cytophagia 976|Bacteroidetes S RDD family - - - - - - - - - - - - RDD SRD1_k127_4070448_0 1191523.MROS_0601 1.938e-61 216.0 COG0173@1|root,COG0173@2|Bacteria 2|Bacteria J aspartate-tRNA(Asn) ligase activity aspS GO:0003674,GO:0003824,GO:0004812,GO:0004815,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006422,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - iJN678.aspS,iSFV_1184.SFV_1868 GAD,tRNA-synt_2,tRNA_anti-codon SRD1_k127_4076443_0 204669.Acid345_1623 7.306e-205 643.0 COG0205@1|root,COG0205@2|Bacteria,3Y4A9@57723|Acidobacteria,2JKQ8@204432|Acidobacteriia 204432|Acidobacteriia G Phosphofructokinase - - 2.7.1.11,2.7.1.90 ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130 - R00756,R00764,R02073,R03236,R04779 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PFK SRD1_k127_4076443_3 517418.Ctha_1666 8.669e-16 83.0 COG1366@1|root,COG1366@2|Bacteria 2|Bacteria T antisigma factor binding rsbV - - ko:K04749 - - - - ko00000,ko03021 - - - STAS,STAS_2 SRD1_k127_4076443_2 929703.KE386491_gene3004 3.851e-97 327.0 COG2367@1|root,COG2367@2|Bacteria,4NDYP@976|Bacteroidetes,47MZ5@768503|Cytophagia 976|Bacteroidetes V Beta-lactamase enzyme family - - 3.5.2.6 ko:K17836 ko00311,ko01130,ko01501,map00311,map01130,map01501 M00627,M00628 R06363 RC01499 ko00000,ko00001,ko00002,ko01000,ko01504 - - - Beta-lactamase2 SRD1_k127_4076443_1 1191523.MROS_1496 1.986e-123 404.0 COG0612@1|root,COG0612@2|Bacteria 2|Bacteria L Peptidase, M16 - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C SRD1_k127_4083371_0 335543.Sfum_2246 0.0 1119.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,42NCZ@68525|delta/epsilon subdivisions,2WK3X@28221|Deltaproteobacteria,2MRHY@213462|Syntrophobacterales 28221|Deltaproteobacteria P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K07787 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4 - iAF987.Gmet_1547 ACR_tran SRD1_k127_4083371_1 335543.Sfum_2247 5.067e-45 170.0 COG0845@1|root,COG3350@1|root,COG0845@2|Bacteria,COG3350@2|Bacteria,1MVAS@1224|Proteobacteria,42PKU@68525|delta/epsilon subdivisions,2WM5K@28221|Deltaproteobacteria,2MRTA@213462|Syntrophobacterales 28221|Deltaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K07798 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4,8.A.1 - - DUF3347,HlyD_D23 SRD1_k127_4110555_1 330214.NIDE1971 2.396e-24 109.0 COG3522@1|root,COG3522@2|Bacteria,3J17B@40117|Nitrospirae 40117|Nitrospirae S Bacterial Type VI secretion, VC_A0110, EvfL, ImpJ, VasE - - - ko:K11893 ko02025,map02025 M00334 - - ko00000,ko00001,ko00002,ko02044 3.A.23.1 - - T6SS_VasE SRD1_k127_4110555_2 1173028.ANKO01000065_gene5619 5.084e-12 78.0 COG0842@1|root,COG1131@1|root,COG1716@1|root,COG0842@2|Bacteria,COG1131@2|Bacteria,COG1716@2|Bacteria,1G102@1117|Cyanobacteria,1H919@1150|Oscillatoriales 1117|Cyanobacteria V Inner membrane component of T3SS, cytoplasmic domain - - - - - - - - - - - - ABC2_membrane,ABC_tran,FHA SRD1_k127_4110555_0 880073.Calab_0428 6.346e-69 249.0 COG0515@1|root,COG0515@2|Bacteria,2NPFQ@2323|unclassified Bacteria 2|Bacteria KLT Serine threonine protein kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase SRD1_k127_4112361_0 1089547.KB913013_gene2908 3.322e-174 576.0 COG4953@1|root,COG4953@2|Bacteria,4NEG5@976|Bacteroidetes,47KYC@768503|Cytophagia 976|Bacteroidetes M penicillin-binding protein 1C - - 2.4.1.129 ko:K05367 ko00550,map00550 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - BiPBP_C,Transgly,Transpeptidase SRD1_k127_4112361_1 661478.OP10G_0240 2.456e-53 205.0 COG1626@1|root,COG1626@2|Bacteria 2|Bacteria G alpha,alpha-trehalase activity ygjK GO:0003674,GO:0003824,GO:0004553,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0015926,GO:0016787,GO:0016798,GO:0033554,GO:0050896,GO:0051716 3.2.1.28 ko:K01194,ko:K03931 ko00500,ko01100,map00500,map01100 - R00010 RC00049 ko00000,ko00001,ko00537,ko01000 - GH37,GH63 - Glyco_hydro_63,Trehalase SRD1_k127_4113272_1 1006004.GBAG_2788 4.52e-65 228.0 COG1312@1|root,COG1312@2|Bacteria,1MWYD@1224|Proteobacteria,1RR0Q@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Catalyzes the dehydration of D-mannonate uxuA GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005975,GO:0005996,GO:0006063,GO:0006064,GO:0006082,GO:0008150,GO:0008152,GO:0008198,GO:0008927,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0019585,GO:0019752,GO:0030145,GO:0032787,GO:0042839,GO:0042840,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046365,GO:0046395,GO:0046872,GO:0046914,GO:0071704,GO:0072329,GO:1901575 4.2.1.8 ko:K01686 ko00040,ko01100,map00040,map01100 M00061 R05606 RC00543 ko00000,ko00001,ko00002,ko01000 - - - UxuA SRD1_k127_4113272_0 1191523.MROS_2076 7.07e-322 1002.0 COG1472@1|root,COG1472@2|Bacteria 2|Bacteria G Belongs to the glycosyl hydrolase 3 family - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C SRD1_k127_4113272_2 234267.Acid_2680 3.582e-21 94.0 COG2211@1|root,COG2211@2|Bacteria,3Y7MD@57723|Acidobacteria 57723|Acidobacteria G MFS/sugar transport protein - - - - - - - - - - - - MFS_2 SRD1_k127_4116279_3 1191523.MROS_0941 2.145e-105 350.0 COG1131@1|root,COG1131@2|Bacteria 2|Bacteria V ATPase activity - - - ko:K01990,ko:K13926 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran,DUF4162 SRD1_k127_4116279_7 518766.Rmar_1779 3.65e-51 199.0 COG1538@1|root,COG1538@2|Bacteria,4NDZ6@976|Bacteroidetes 976|Bacteroidetes MU Outer membrane efflux protein - - - - - - - - - - - - OEP SRD1_k127_4116279_2 945713.IALB_2917 1.609e-117 385.0 COG1131@1|root,COG1131@2|Bacteria 2|Bacteria V ATPase activity ybhF-C - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran,DUF4162 SRD1_k127_4116279_6 518766.Rmar_1781 7.879e-92 321.0 COG0842@1|root,COG0842@2|Bacteria,4NDU0@976|Bacteroidetes 976|Bacteroidetes V transport, permease protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 SRD1_k127_4116279_5 1191523.MROS_0938 2.396e-99 345.0 COG0842@1|root,COG0842@2|Bacteria 2|Bacteria V Transport permease protein ybhR GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006855,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0015562,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0033554,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0071944 - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 SRD1_k127_4116279_10 1233951.IO90_08055 1.098e-06 61.0 COG4775@1|root,COG4775@2|Bacteria,4NF9N@976|Bacteroidetes,1HYFE@117743|Flavobacteriia,3HIPJ@358033|Chryseobacterium 976|Bacteroidetes M Calcineurin-like phosphoesterase - - - - - - - - - - - - Bac_surface_Ag,Metallophos,ShlB SRD1_k127_4116279_8 234267.Acid_7882 9.094e-45 171.0 COG5587@1|root,COG5587@2|Bacteria,3Y4D4@57723|Acidobacteria 57723|Acidobacteria S Conserved hypothetical protein (DUF2461) - - - - - - - - - - - - DUF2461 SRD1_k127_4116279_1 909663.KI867150_gene1011 1.056e-117 392.0 COG0577@1|root,COG0577@2|Bacteria,1MX7X@1224|Proteobacteria,42NT4@68525|delta/epsilon subdivisions,2WJFM@28221|Deltaproteobacteria,2MQ5K@213462|Syntrophobacterales 28221|Deltaproteobacteria V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD SRD1_k127_4116279_0 1379698.RBG1_1C00001G1667 1.529e-123 407.0 COG0577@1|root,COG0577@2|Bacteria,2NQPT@2323|unclassified Bacteria 2|Bacteria V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD SRD1_k127_4116279_4 1379698.RBG1_1C00001G1666 2.857e-103 340.0 COG1136@1|root,COG1136@2|Bacteria,2NPA8@2323|unclassified Bacteria 2|Bacteria V ABC transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran SRD1_k127_4116279_9 264198.Reut_B5856 1.831e-07 55.0 COG0845@1|root,COG0845@2|Bacteria,1MUMV@1224|Proteobacteria,2VIYG@28216|Betaproteobacteria,1K520@119060|Burkholderiaceae 28216|Betaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - HlyD_D23 SRD1_k127_4119898_0 880073.Calab_0292 4.404e-173 571.0 COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,2NNNP@2323|unclassified Bacteria 2|Bacteria D CobQ CobB MinD ParA nucleotide binding domain - - - ko:K16554,ko:K16692 ko05111,map05111 - - - ko00000,ko00001,ko01000,ko01001,ko02000 8.A.3.1 - - AAA_31,CbiA,GNVR,ParA,Wzz SRD1_k127_4119898_3 1089553.Tph_c02710 1.505e-90 317.0 COG2244@1|root,COG2244@2|Bacteria,1V929@1239|Firmicutes 1239|Firmicutes S Polysaccharide biosynthesis protein - - - - - - - - - - - - Polysacc_synt,Polysacc_synt_3,Polysacc_synt_C SRD1_k127_4119898_4 272134.KB731324_gene4066 6.437e-63 226.0 COG0463@1|root,COG0463@2|Bacteria 2|Bacteria M Glycosyl transferase, family 2 - - - - - - - - - - - - Glycos_transf_2 SRD1_k127_4119898_6 1267533.KB906734_gene3921 7.738e-07 57.0 2E0ZH@1|root,32WFR@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - O_anti_polymase SRD1_k127_4119898_5 1267533.KB906734_gene3921 3.898e-19 98.0 2E0ZH@1|root,32WFR@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - O_anti_polymase SRD1_k127_4119898_1 760568.Desku_1745 6.772e-102 343.0 COG0438@1|root,COG0438@2|Bacteria,1V5W1@1239|Firmicutes,24HV6@186801|Clostridia,263ZC@186807|Peptococcaceae 186801|Clostridia M Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_trans_1_4 SRD1_k127_4119898_2 1173022.Cri9333_3495 3.897e-98 334.0 COG0438@1|root,COG0438@2|Bacteria,1G06H@1117|Cyanobacteria,1H9J8@1150|Oscillatoriales 1117|Cyanobacteria M PFAM Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1 SRD1_k127_4128945_1 1499967.BAYZ01000171_gene5567 9.93e-100 335.0 COG1148@1|root,COG4231@1|root,COG1148@2|Bacteria,COG4231@2|Bacteria 2|Bacteria C indolepyruvate ferredoxin oxidoreductase activity bamE - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - FAD_oxidored,Fer4,Fer4_20,Fer4_7,Pyr_redox_2 SRD1_k127_4128945_0 1125863.JAFN01000001_gene3361 3.553e-102 336.0 COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,42N6N@68525|delta/epsilon subdivisions,2WJ1W@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Respiratory-chain NADH dehydrogenase domain 51 kDa subunit bamH - 1.6.5.3 ko:K00124,ko:K00335 ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200 M00144 R00519,R11945 RC00061,RC02796 ko00000,ko00001,ko00002,ko01000 3.D.1 - iAF987.Gmet_2080 2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB SRD1_k127_4144949_7 945713.IALB_2051 1.838e-17 85.0 COG0457@1|root,COG0457@2|Bacteria 945713.IALB_2051|- S peptidyl-tyrosine sulfation - - - - - - - - - - - - - SRD1_k127_4144949_2 945713.IALB_2052 4.711e-119 407.0 COG0457@1|root,COG0457@2|Bacteria 945713.IALB_2052|- S peptidyl-tyrosine sulfation - - - - - - - - - - - - - SRD1_k127_4144949_5 1191523.MROS_0395 9.978e-44 169.0 COG1729@1|root,COG1729@2|Bacteria 2|Bacteria S protein trimerization - - - - - - - - - - - - TPR_16,TPR_2,TPR_6,TPR_8 SRD1_k127_4144949_4 1191523.MROS_0396 4.031e-105 353.0 COG2304@1|root,COG2304@2|Bacteria 2|Bacteria IU oxidoreductase activity batB - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - BatA,VWA,VWA_2 SRD1_k127_4144949_1 1191523.MROS_0397 9.874e-129 419.0 COG2304@1|root,COG2304@2|Bacteria 2|Bacteria IU oxidoreductase activity batA - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - BatA,VWA SRD1_k127_4144949_6 1191523.MROS_0398 1.33e-41 166.0 COG3088@1|root,COG3088@2|Bacteria 2|Bacteria O cytochrome complex assembly ccmH GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009897,GO:0009986,GO:0009987,GO:0015035,GO:0015036,GO:0016020,GO:0016043,GO:0016491,GO:0016667,GO:0017003,GO:0017004,GO:0017006,GO:0018063,GO:0018193,GO:0018198,GO:0018378,GO:0019538,GO:0022607,GO:0031224,GO:0031226,GO:0031233,GO:0031237,GO:0034622,GO:0036211,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:0098552,GO:0098567,GO:1901564 - ko:K02198,ko:K02200,ko:K04016,ko:K04017,ko:K04018 - - R05712 RC00176 ko00000,ko02000 9.B.14.1 - - CcmH SRD1_k127_4144949_3 1121100.JCM6294_2473 2.976e-107 354.0 COG1721@1|root,COG1721@2|Bacteria,4NE2N@976|Bacteroidetes,2FNSY@200643|Bacteroidia,4AKQH@815|Bacteroidaceae 976|Bacteroidetes S protein (some members contain a von Willebrand factor type A (vWA) domain) - - - - - - - - - - - - DUF58 SRD1_k127_4144949_0 945713.IALB_2058 1.392e-160 511.0 COG0714@1|root,COG0714@2|Bacteria 2|Bacteria KLT Associated with various cellular activities moxR - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 SRD1_k127_4183563_14 1519464.HY22_02940 1.399e-10 70.0 COG4783@1|root,COG4783@2|Bacteria 2|Bacteria L chaperone-mediated protein folding - - - ko:K02660 ko02020,ko02025,map02020,map02025 - - - ko00000,ko00001,ko02035,ko02044 - - - MCPsignal,PQQ_2,TPR_8 SRD1_k127_4183563_1 1191523.MROS_2277 3.554e-164 526.0 COG0766@1|root,COG0766@2|Bacteria 2|Bacteria M UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity murA GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008760,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016740,GO:0016765,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.5.1.7 ko:K00790 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R00660 RC00350 ko00000,ko00001,ko01000,ko01011 - - - EPSP_synthase SRD1_k127_4183563_9 269799.Gmet_1931 6.679e-33 132.0 COG1959@1|root,COG1959@2|Bacteria,1MZ1C@1224|Proteobacteria,42SPF@68525|delta/epsilon subdivisions,2WPVC@28221|Deltaproteobacteria,43UWZ@69541|Desulfuromonadales 28221|Deltaproteobacteria K transcriptional regulator, Rrf2 family - - - - - - - - - - - - Rrf2 SRD1_k127_4183563_0 1191523.MROS_0843 3.361e-193 612.0 COG1271@1|root,COG1271@2|Bacteria 2|Bacteria C aerobic electron transport chain cydA GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016679,GO:0016682,GO:0019646,GO:0020037,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046906,GO:0048037,GO:0055114,GO:0070069,GO:0071944,GO:0097159,GO:1901363 1.10.3.14 ko:K00425 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 - iPC815.YPO1117,iSBO_1134.SBO_2253,iSFxv_1172.SFxv_0621,iS_1188.S0577,iSbBS512_1146.SbBS512_E2337 Cyt_bd_oxida_I SRD1_k127_4183563_5 1191523.MROS_0842 1.907e-119 393.0 COG1294@1|root,COG1294@2|Bacteria 2|Bacteria C oxidative phosphorylation cydB GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016679,GO:0016682,GO:0019646,GO:0020037,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046906,GO:0048037,GO:0055114,GO:0070069,GO:0071944,GO:0097159,GO:1901363 1.10.3.14 ko:K00426 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 - iECABU_c1320.ECABU_c10120,iLF82_1304.LF82_0101,iNRG857_1313.NRG857_04455,iPC815.YPO1118,ic_1306.c1120 Cyt_bd_oxida_II SRD1_k127_4183563_6 518766.Rmar_2346 5.098e-77 265.0 COG1428@1|root,COG1428@2|Bacteria,4NFA8@976|Bacteroidetes,1FINM@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes F Deoxynucleoside kinase dck - - - - - - - - - - - dNK SRD1_k127_4183563_10 1124983.PFLCHA0_c58510 4.237e-24 113.0 COG0730@1|root,COG0730@2|Bacteria,1R3V4@1224|Proteobacteria,1RVNC@1236|Gammaproteobacteria,1YPV8@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria S membrane transporter protein - - - ko:K07090 - - - - ko00000 - - - TauE SRD1_k127_4183563_2 517418.Ctha_0607 1.626e-145 481.0 COG0793@1|root,COG0793@2|Bacteria,1FDHB@1090|Chlorobi 1090|Chlorobi M Belongs to the peptidase S41A family - - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_S41 SRD1_k127_4183563_8 1410638.JHXJ01000006_gene2548 3.058e-52 192.0 COG0125@1|root,COG0125@2|Bacteria,1V1HE@1239|Firmicutes,24HHC@186801|Clostridia,3WJF4@541000|Ruminococcaceae 186801|Clostridia F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis tmk - 2.7.4.9 ko:K00943 ko00240,ko01100,map00240,map01100 M00053 R02094,R02098 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Thymidylate_kin SRD1_k127_4183563_7 517418.Ctha_1196 2.273e-66 232.0 COG1595@1|root,COG1595@2|Bacteria,1FESW@1090|Chlorobi 1090|Chlorobi K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 SRD1_k127_4183563_13 926569.ANT_13170 2.7e-16 89.0 COG4758@1|root,COG4758@2|Bacteria,2G93M@200795|Chloroflexi 200795|Chloroflexi S membrane - - - - - - - - - - - - - SRD1_k127_4183563_4 1121440.AUMA01000005_gene2707 1.546e-137 449.0 COG2957@1|root,COG2957@2|Bacteria,1MX65@1224|Proteobacteria,42NAS@68525|delta/epsilon subdivisions,2WNAF@28221|Deltaproteobacteria,2M9I9@213115|Desulfovibrionales 28221|Deltaproteobacteria E Belongs to the agmatine deiminase family aguA - 3.5.3.12 ko:K10536 ko00330,ko01100,map00330,map01100 - R01416 RC00177 ko00000,ko00001,ko01000 - - - PAD_porph SRD1_k127_4183563_3 945713.IALB_1038 1.451e-138 445.0 COG0388@1|root,COG0388@2|Bacteria 2|Bacteria S hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds aguB - 3.5.1.53 ko:K12251 ko00330,ko01100,map00330,map01100 - R01152 RC00096 ko00000,ko00001,ko01000 - - - CN_hydrolase SRD1_k127_4183563_12 579137.Metvu_1421 2.039e-17 89.0 COG3815@1|root,arCOG03949@2157|Archaea,2XYKM@28890|Euryarchaeota,23R0V@183939|Methanococci 183939|Methanococci S Predicted membrane protein (DUF2085) - - - - - - - - - - - - DUF2085 SRD1_k127_4183563_11 1121930.AQXG01000003_gene2488 1.065e-18 90.0 COG2010@1|root,COG4447@1|root,COG2010@2|Bacteria,COG4447@2|Bacteria 2|Bacteria S cellulose binding - - - - - - - - - - - - Cu_amine_oxidN1,FlgD_ig,PSCyt1,PSCyt3,PSD2 SRD1_k127_4184221_1 504472.Slin_3630 0.0003464 51.0 2C08E@1|root,2ZBCG@2|Bacteria,4NGBR@976|Bacteroidetes,47MV3@768503|Cytophagia 976|Bacteroidetes - - - - - - - - - - - - - - - SRD1_k127_4184221_0 504472.Slin_6044 2.902e-150 490.0 COG0308@1|root,COG0308@2|Bacteria,4NEXH@976|Bacteroidetes,47JGQ@768503|Cytophagia 976|Bacteroidetes E PFAM Peptidase M1, membrane alanine aminopeptidase - - 3.4.11.2 ko:K01256 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M1 SRD1_k127_4218081_2 518766.Rmar_2397 3.69e-75 258.0 28KE7@1|root,2ZA0G@2|Bacteria,4P0D4@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - SRD1_k127_4218081_0 518766.Rmar_2396 4.371e-126 414.0 COG2067@1|root,COG2067@2|Bacteria 2|Bacteria I long-chain fatty acid transporting porin activity - - - - - - - - - - - - - SRD1_k127_4218081_1 518766.Rmar_2395 2.942e-75 269.0 COG2067@1|root,COG2067@2|Bacteria 2|Bacteria I long-chain fatty acid transporting porin activity - - - - - - - - - - - - DUF3187,DUF3570,OprB,Toluene_X SRD1_k127_4228363_1 426114.THI_2275 4.364e-142 484.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2W8XA@28216|Betaproteobacteria,1KPEJ@119065|unclassified Burkholderiales 28216|Betaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran SRD1_k127_4228363_4 926566.Terro_3363 2.8e-16 92.0 COG0845@1|root,COG0845@2|Bacteria,3Y6F8@57723|Acidobacteria,2JKV9@204432|Acidobacteriia 204432|Acidobacteriia M HlyD family secretion protein - - - ko:K15727 - - - - ko00000,ko02000 8.A.1.2.1 - - HlyD_D23 SRD1_k127_4228363_5 220664.PFL_5374 0.0002433 53.0 COG1538@1|root,COG1538@2|Bacteria,1Q498@1224|Proteobacteria,1RS7N@1236|Gammaproteobacteria,1YSZN@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria MU Outer membrane efflux protein hasF - - ko:K12538 - M00328 - - ko00000,ko00002,ko02000,ko02044 1.B.17.1 - - OEP SRD1_k127_4228363_0 204669.Acid345_3252 1.927e-182 581.0 COG1271@1|root,COG1271@2|Bacteria,3Y44V@57723|Acidobacteria,2JJ96@204432|Acidobacteriia 204432|Acidobacteriia C Cytochrome bd terminal oxidase subunit I - - 1.10.3.14 ko:K00425 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - Cyt_bd_oxida_I SRD1_k127_4228363_2 1382306.JNIM01000001_gene3592 2.093e-114 381.0 COG1294@1|root,COG1294@2|Bacteria,2G67G@200795|Chloroflexi 200795|Chloroflexi C PFAM cytochrome bd ubiquinol oxidase subunit II - - 1.10.3.14 ko:K00426 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - Cyt_bd_oxida_II SRD1_k127_4228363_3 1519464.HY22_08830 3.387e-103 366.0 COG0642@1|root,COG2208@1|root,COG2205@2|Bacteria,COG2208@2|Bacteria 2|Bacteria T phosphoserine phosphatase activity rsbU - 3.1.3.3 ko:K07315 - - - - ko00000,ko01000,ko03021 - - - GAF_2,GAF_3,SpoIIE SRD1_k127_4232456_3 518766.Rmar_0006 1.387e-42 159.0 COG0103@1|root,COG0103@2|Bacteria,4NNN1@976|Bacteroidetes,1FJFJ@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes J Belongs to the universal ribosomal protein uS9 family rpsI GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02996 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S9 SRD1_k127_4232456_2 1191523.MROS_1684 1.146e-54 196.0 COG0102@1|root,COG0102@2|Bacteria 2|Bacteria J mRNA binding rplM GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0017148,GO:0019222,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0070180,GO:0071704,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113 - ko:K02871 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L13 SRD1_k127_4232456_0 518766.Rmar_2195 4.699e-120 392.0 COG0320@1|root,COG0320@2|Bacteria,4NEB5@976|Bacteroidetes,1FIV9@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes H Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives lipA - 2.8.1.8 ko:K03644 ko00785,ko01100,map00785,map01100 - R07767,R07768 RC01978 ko00000,ko00001,ko01000 - - - LIAS_N,Radical_SAM SRD1_k127_4232456_1 880073.Calab_0664 9.618e-89 304.0 COG0508@1|root,COG0508@2|Bacteria,2NNZ8@2323|unclassified Bacteria 2|Bacteria C e3 binding domain bfmBB - 2.3.1.168,2.3.1.61 ko:K00658,ko:K09699 ko00020,ko00280,ko00310,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00280,map00310,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032,M00036 R02570,R02571,R02662,R03174,R04097,R08549,R10998 RC00004,RC02727,RC02833,RC02870 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding SRD1_k127_4235047_4 323848.Nmul_A2692 1.022e-13 73.0 COG0621@1|root,COG0621@2|Bacteria,1MURS@1224|Proteobacteria,2VHQM@28216|Betaproteobacteria,371SR@32003|Nitrosomonadales 28216|Betaproteobacteria J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine miaB - 2.8.4.3 ko:K06168 - - R10645,R10646,R10647 RC00003,RC00980,RC03221,RC03222 ko00000,ko01000,ko03016 - - - Radical_SAM,TRAM,UPF0004 SRD1_k127_4235047_3 945713.IALB_0611 3.577e-14 83.0 COG1729@1|root,COG3147@1|root,COG1729@2|Bacteria,COG3147@2|Bacteria 2|Bacteria S peptidoglycan binding - - 3.1.26.12 ko:K03749,ko:K07114,ko:K08300,ko:K09859 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko02000,ko03009,ko03019 1.A.13.2.2,1.A.13.2.3 - - DUF3108,Rib,SPOR,TPR_6 SRD1_k127_4235047_1 880073.Calab_3385 1.266e-110 369.0 COG2204@1|root,COG2204@2|Bacteria,2NQDH@2323|unclassified Bacteria 2|Bacteria T Sigma-54 interaction domain fhlA - - ko:K03413,ko:K13589 ko02020,ko02030,ko04112,map02020,map02030,map04112 M00506,M00512 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - HTH_8,Response_reg,Sigma54_activat SRD1_k127_4235047_0 1191523.MROS_1614 8.303e-219 689.0 COG1215@1|root,COG1215@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups - - 2.4.1.12 ko:K00694,ko:K00786 ko00500,ko01100,ko02026,map00500,map01100,map02026 - R02889 RC00005 ko00000,ko00001,ko01000,ko01003,ko02000 4.D.3.1.2,4.D.3.1.5,4.D.3.1.6 GT2 - Glyco_tranf_2_3 SRD1_k127_4235402_4 1191523.MROS_0274 1.59e-13 74.0 COG0711@1|root,COG0711@2|Bacteria 2|Bacteria C ATP synthesis coupled proton transport atpF - - ko:K02109 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_B SRD1_k127_4235402_2 215803.DB30_3939 4.647e-24 103.0 COG0636@1|root,COG0636@2|Bacteria 2|Bacteria C ATP hydrolysis coupled proton transport atpE GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - ko:K02110 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - iHN637.CLJU_RS01165 ATP-synt_C SRD1_k127_4235402_0 378806.STAUR_8067 1.508e-75 265.0 COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,42NR9@68525|delta/epsilon subdivisions,2WKX1@28221|Deltaproteobacteria,2YVR0@29|Myxococcales 28221|Deltaproteobacteria C it plays a direct role in the translocation of protons across the membrane atpB - - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - - ATP-synt_A SRD1_k127_4235402_6 517417.Cpar_2053 9.148e-09 62.0 2E2P0@1|root,32XRZ@2|Bacteria,1FE9C@1090|Chlorobi 1090|Chlorobi - - - - - - - - - - - - - - - SRD1_k127_4235402_5 1157490.EL26_09205 3.385e-09 61.0 COG5336@1|root,COG5336@2|Bacteria,1VF5M@1239|Firmicutes,4I9VP@91061|Bacilli,278Q1@186823|Alicyclobacillaceae 91061|Bacilli S Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter - - - - - - - - - - - - ATPase_gene1 SRD1_k127_4235402_3 1235800.C819_01221 1.413e-17 88.0 COG1664@1|root,COG1664@2|Bacteria,1VEVU@1239|Firmicutes,24QT5@186801|Clostridia,27NRD@186928|unclassified Lachnospiraceae 186801|Clostridia M Polymer-forming cytoskeletal - - - - - - - - - - - - Bactofilin SRD1_k127_4235402_1 880073.Calab_0241 1.287e-31 136.0 COG0739@1|root,COG0739@2|Bacteria 2|Bacteria M heme binding nlpD_2 - - ko:K06194,ko:K19304 - - - - ko00000,ko01000,ko01002,ko01011 1.A.34.1.2 - - Peptidase_M23 SRD1_k127_4240958_6 929703.KE386491_gene3154 1.926e-10 70.0 COG0584@1|root,COG0584@2|Bacteria,4NGI1@976|Bacteroidetes,47MFN@768503|Cytophagia 976|Bacteroidetes C PFAM Glycerophosphoryl diester phosphodiesterase glpQ - 3.1.4.46 ko:K01126 ko00564,map00564 - R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 - - - GDPD,Phytase-like SRD1_k127_4240958_2 1121104.AQXH01000006_gene2283 1.431e-52 202.0 COG0767@1|root,COG0767@2|Bacteria,4NEZ8@976|Bacteroidetes,1IQDU@117747|Sphingobacteriia 976|Bacteroidetes Q ABC-type transport system involved in resistance to organic solvents permease component mlaE - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE SRD1_k127_4240958_1 1047013.AQSP01000138_gene1010 2.677e-71 249.0 COG1127@1|root,COG1127@2|Bacteria,2NP3U@2323|unclassified Bacteria 2|Bacteria Q ABC-type transport system involved in resistance to organic solvents, ATPase component mkl - - ko:K02065 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - ABC_tran SRD1_k127_4240958_5 313603.FB2170_09896 9.908e-34 141.0 COG1463@1|root,COG1463@2|Bacteria,4NHT9@976|Bacteroidetes,1HXN5@117743|Flavobacteriia,2PG7R@252356|Maribacter 976|Bacteroidetes Q MlaD protein - - - ko:K02067 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaD SRD1_k127_4240958_4 1122605.KB893647_gene321 5.31e-43 171.0 28H8Z@1|root,30SVU@2|Bacteria,4NY56@976|Bacteroidetes 976|Bacteroidetes S Yip1 domain - - - - - - - - - - - - Yip1 SRD1_k127_4240958_0 945713.IALB_0790 6.575e-163 527.0 COG0624@1|root,COG0624@2|Bacteria 2|Bacteria E succinyl-diaminopimelate desuccinylase activity dapE - 3.5.1.16,3.5.1.18 ko:K01436,ko:K01438,ko:K01439 ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00028,M00845 R00669,R02734,R09107 RC00064,RC00090,RC00300 ko00000,ko00001,ko00002,ko01000,ko01002 - - - M20_dimer,Peptidase_M20 SRD1_k127_4240958_3 1191523.MROS_1603 4.577e-51 189.0 COG2267@1|root,COG2267@2|Bacteria 2|Bacteria I carboxylic ester hydrolase activity mhpC - - - - - - - - - - - Abhydrolase_1,Abhydrolase_4,Abhydrolase_6 SRD1_k127_4242979_0 861299.J421_1580 1.888e-128 447.0 COG1629@1|root,COG4771@2|Bacteria,1ZUP3@142182|Gemmatimonadetes 142182|Gemmatimonadetes P Carboxypeptidase regulatory-like domain - - - - - - - - - - - - CarboxypepD_reg SRD1_k127_4242979_1 883126.HMPREF9710_03795 9.109e-86 295.0 COG2234@1|root,COG2234@2|Bacteria,1MWBX@1224|Proteobacteria,2WCZI@28216|Betaproteobacteria,476J7@75682|Oxalobacteraceae 28216|Betaproteobacteria S Peptidase family M28 - - - - - - - - - - - - Peptidase_M28 SRD1_k127_4254824_1 395964.KE386496_gene1674 5.611e-75 256.0 COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,2TQUE@28211|Alphaproteobacteria,3NAN3@45404|Beijerinckiaceae 28211|Alphaproteobacteria F Adenylosuccinate lyase C-terminus purB GO:0003674,GO:0003824,GO:0004018,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016840,GO:0016842,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046033,GO:0046390,GO:0046483,GO:0055086,GO:0070626,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 - - - ADSL_C,Lyase_1 SRD1_k127_4254824_0 518766.Rmar_1303 6.708e-212 668.0 COG1012@1|root,COG1012@2|Bacteria,4NEB7@976|Bacteroidetes,1FINT@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes C Belongs to the aldehyde dehydrogenase family mmsA - 1.2.1.18,1.2.1.27 ko:K00140,ko:K22187 ko00040,ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00040,map00280,map00410,map00562,map00640,map01100,map01200 M00013 R00705,R00706,R00922,R00935,R11768 RC00004,RC00080,RC02723,RC02817 ko00000,ko00001,ko00002,ko01000 - - - Aldedh SRD1_k127_4254824_2 443218.AS9A_4565 1.322e-09 63.0 COG0160@1|root,COG0160@2|Bacteria,2GJNQ@201174|Actinobacteria,233JV@1762|Mycobacteriaceae 201174|Actinobacteria E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family lat - 2.6.1.36 ko:K03918 ko01100,map01100 - R00457 RC00006,RC00062 ko00000,ko01000,ko01007 - - iNJ661.Rv3290c Aminotran_3 SRD1_k127_4268851_0 945713.IALB_1305 5.965e-149 486.0 COG3005@1|root,COG3005@2|Bacteria 2|Bacteria C denitrification pathway - GO:0003674,GO:0003824,GO:0005575,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0022900,GO:0031224,GO:0044237,GO:0044425,GO:0045333,GO:0055114 - ko:K15876 ko00910,ko01120,map00910,map01120 M00530 R05712 RC00176 ko00000,ko00001,ko00002 - - - Cytochrom_NNT,Cytochrom_c3_2 SRD1_k127_4268851_4 945713.IALB_1840 3.133e-33 136.0 COG3391@1|root,COG3391@2|Bacteria 2|Bacteria CO amine dehydrogenase activity - - - ko:K21449 - - - - ko00000,ko02000 1.B.40.2 - - Cytochrome_C554,DUF11,SLH SRD1_k127_4268851_1 1379698.RBG1_1C00001G0777 6.915e-102 339.0 COG2864@1|root,COG2864@2|Bacteria,2NQFM@2323|unclassified Bacteria 2|Bacteria P Prokaryotic cytochrome b561 cbcY - - - - - - - - - - - Cytochrom_c3_2,Cytochrome_C7,Ni_hydr_CYTB,Paired_CXXCH_1,Rhodanese SRD1_k127_4268851_2 1379698.RBG1_1C00001G0777 2.748e-84 284.0 COG2864@1|root,COG2864@2|Bacteria,2NQFM@2323|unclassified Bacteria 2|Bacteria P Prokaryotic cytochrome b561 cbcY - - - - - - - - - - - Cytochrom_c3_2,Cytochrome_C7,Ni_hydr_CYTB,Paired_CXXCH_1,Rhodanese SRD1_k127_4300084_6 194439.CT1585 7.089e-18 84.0 COG0848@1|root,COG0848@2|Bacteria,1FDZ1@1090|Chlorobi 1090|Chlorobi U Outer membrane transport energization protein ExbD - - - - - - - - - - - - ExbD SRD1_k127_4300084_4 517418.Ctha_2332 1.102e-66 235.0 COG0811@1|root,COG0811@2|Bacteria,1FDN2@1090|Chlorobi 1090|Chlorobi U PFAM MotA TolQ ExbB proton channel - - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB SRD1_k127_4300084_9 56110.Oscil6304_4158 0.000737 48.0 COG1366@1|root,COG1366@2|Bacteria,1G7ZR@1117|Cyanobacteria,1HD6H@1150|Oscillatoriales 1117|Cyanobacteria T COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) - - - - - - - - - - - - STAS,STAS_2 SRD1_k127_4300084_0 690850.Desaf_3186 4.236e-122 408.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42P8Q@68525|delta/epsilon subdivisions,2WK2B@28221|Deltaproteobacteria,2MABU@213115|Desulfovibrionales 28221|Deltaproteobacteria T two component, sigma54 specific, transcriptional regulator, Fis family - - - ko:K11384 ko02020,map02020 M00505 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat SRD1_k127_4300084_1 926561.KB900617_gene2339 7.464e-120 407.0 COG5002@1|root,COG5002@2|Bacteria,1TQV5@1239|Firmicutes,248PK@186801|Clostridia,3WAZH@53433|Halanaerobiales 186801|Clostridia T histidine kinase HAMP region domain protein - - - - - - - - - - - - 4HB_MCP_1,HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_9 SRD1_k127_4300084_8 517418.Ctha_0767 7.082e-05 53.0 2F7NH@1|root,3402Z@2|Bacteria,1FFE9@1090|Chlorobi 1090|Chlorobi - - - - - - - - - - - - - - - SRD1_k127_4300084_3 562970.Btus_0302 1.673e-92 324.0 COG1253@1|root,COG1253@2|Bacteria,1TPN0@1239|Firmicutes,4H9SB@91061|Bacilli,277VB@186823|Alicyclobacillaceae 91061|Bacilli S Transporter associated domain corC1 - - - - - - - - - - - CBS,CorC_HlyC,DUF21 SRD1_k127_4300084_2 888055.HMPREF9015_01179 2.816e-109 359.0 COG0207@1|root,COG0207@2|Bacteria,378NE@32066|Fusobacteria 32066|Fusobacteria F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis thyA - 2.1.1.45 ko:K00560 ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523 M00053 R02101 RC00219,RC00332 ko00000,ko00001,ko00002,ko01000 - - - Thymidylat_synt SRD1_k127_4300084_5 1123354.AUDR01000014_gene909 7.471e-40 153.0 COG0262@1|root,COG0262@2|Bacteria,1RH0P@1224|Proteobacteria,2VSH8@28216|Betaproteobacteria,1KRS3@119069|Hydrogenophilales 119069|Hydrogenophilales H Dihydrofolate reductase - - 1.5.1.3 ko:K00287 ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523 M00126,M00840 R00936,R00937,R00939,R00940,R02235,R02236,R11765 RC00109,RC00110,RC00158 ko00000,ko00001,ko00002,ko01000 - - - DHFR_1 SRD1_k127_4300084_7 1131813.AQVT01000001_gene2358 2.261e-09 70.0 COG4715@1|root,COG4715@2|Bacteria,1R60K@1224|Proteobacteria,2U4S9@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Zinc finger, swim domain protein - - - - - - - - - - - - SWIM SRD1_k127_4319275_0 1121129.KB903367_gene2718 1.5e-96 327.0 COG0079@1|root,COG0079@2|Bacteria,4NEW8@976|Bacteroidetes,2FMKS@200643|Bacteroidia,22XH3@171551|Porphyromonadaceae 976|Bacteroidetes E Aminotransferase class I and II - - 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 SRD1_k127_4319275_1 742817.HMPREF9449_01416 2.021e-42 171.0 COG1213@1|root,COG1213@2|Bacteria,4NH70@976|Bacteroidetes,2FP2J@200643|Bacteroidia,22XH9@171551|Porphyromonadaceae 976|Bacteroidetes M Nucleotidyl transferase - - - - - - - - - - - - NTP_transf_3,NTP_transferase SRD1_k127_4319275_2 869210.Marky_0727 3.677e-14 84.0 COG0558@1|root,COG0558@2|Bacteria,1WIUS@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus I Belongs to the CDP-alcohol phosphatidyltransferase class-I family - - - - - - - - - - - - CDP-OH_P_transf SRD1_k127_4337686_8 1191523.MROS_0179 1.067e-30 130.0 COG0791@1|root,COG0791@2|Bacteria 2|Bacteria M cysteine-type peptidase activity spr GO:0000270,GO:0003674,GO:0003824,GO:0004175,GO:0006022,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009254,GO:0016787,GO:0019538,GO:0030203,GO:0043170,GO:0044238,GO:0070011,GO:0071704,GO:0140096,GO:1901135,GO:1901564 3.4.17.13 ko:K13694,ko:K13695 - - - - ko00000,ko01000,ko01002,ko01011 - - - NLPC_P60 SRD1_k127_4337686_7 517418.Ctha_1509 2.936e-47 176.0 COG0242@1|root,COG0242@2|Bacteria,1FE2I@1090|Chlorobi 1090|Chlorobi J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions def - 3.5.1.88 ko:K01462 - - - - ko00000,ko01000 - - - Pep_deformylase SRD1_k127_4337686_4 518766.Rmar_2549 2.216e-108 359.0 COG0223@1|root,COG0223@2|Bacteria,4NE8U@976|Bacteroidetes,1FJ62@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus fmt - 2.1.2.9 ko:K00604 ko00670,ko00970,map00670,map00970 - R03940 RC00026,RC00165 ko00000,ko00001,ko01000 - - - Formyl_trans_C,Formyl_trans_N SRD1_k127_4337686_5 945713.IALB_2816 2.455e-108 363.0 COG3203@1|root,COG3203@2|Bacteria 2|Bacteria M Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane - - - - - - - - - - - - Alginate_exp,OprD,Porin_4 SRD1_k127_4337686_0 1191523.MROS_2640 6.41e-140 453.0 COG0226@1|root,COG0226@2|Bacteria 2|Bacteria P phosphate ion binding pstS GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0006950,GO:0006974,GO:0008150,GO:0009314,GO:0009628,GO:0009987,GO:0010921,GO:0015698,GO:0019220,GO:0019222,GO:0030288,GO:0030313,GO:0031323,GO:0031975,GO:0033554,GO:0035303,GO:0042301,GO:0042597,GO:0043167,GO:0043168,GO:0044464,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051174,GO:0051179,GO:0051234,GO:0051336,GO:0051716,GO:0065007,GO:0065009 - ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - iECH74115_1262.ECH74115_5157,iECSP_1301.ECSP_4770,iECs_1301.ECs4664,iG2583_1286.G2583_4518,iZ_1308.Z5219 PBP_like_2 SRD1_k127_4337686_1 1191523.MROS_2639 2.294e-124 406.0 COG0573@1|root,COG0573@2|Bacteria 2|Bacteria P inorganic phosphate transmembrane transporter activity pstC GO:0008150,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044403,GO:0044419,GO:0051704 - ko:K02037,ko:K02038 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - iAF987.Gmet_2702 BPD_transp_1 SRD1_k127_4337686_2 1191523.MROS_2638 3.493e-116 390.0 COG0581@1|root,COG0581@2|Bacteria 2|Bacteria P inorganic phosphate transmembrane transporter activity pstA GO:0008150,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044403,GO:0044419,GO:0051704 - ko:K02037,ko:K02038 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1 SRD1_k127_4337686_3 1191523.MROS_2637 8.194e-109 359.0 COG1117@1|root,COG1117@2|Bacteria 2|Bacteria P ATPase-coupled phosphate ion transmembrane transporter activity pstB - 3.6.3.27 ko:K02036 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.7 - - ABC_tran SRD1_k127_4337686_6 247490.KSU1_B0729 3.098e-55 203.0 COG0704@1|root,COG0704@2|Bacteria,2IYX4@203682|Planctomycetes 203682|Planctomycetes P Plays a role in the regulation of phosphate uptake - - - ko:K02039 - - - - ko00000 - - - PhoU SRD1_k127_4341343_1 1191523.MROS_1603 9.722e-65 231.0 COG2267@1|root,COG2267@2|Bacteria 2|Bacteria I carboxylic ester hydrolase activity mhpC - - - - - - - - - - - Abhydrolase_1,Abhydrolase_4,Abhydrolase_6 SRD1_k127_4341343_2 1499967.BAYZ01000074_gene2111 3.219e-16 81.0 2EGPU@1|root,31UHW@2|Bacteria,2NRWE@2323|unclassified Bacteria 2|Bacteria - - - - - - - - - - - - - - - SRD1_k127_4341343_0 224325.AF_1274 4.35e-275 864.0 COG0458@1|root,arCOG01594@2157|Archaea,2XTVE@28890|Euryarchaeota,245PG@183980|Archaeoglobi 183980|Archaeoglobi F Belongs to the CarB family carB - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS SRD1_k127_4345415_1 517418.Ctha_0342 1.097e-24 105.0 COG0737@1|root,COG3391@1|root,COG0737@2|Bacteria,COG3391@2|Bacteria,1FDAF@1090|Chlorobi 1090|Chlorobi P Belongs to the alkaline phosphatase family - - 3.1.3.1 ko:K01077 ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020 M00126 R02135,R04620 RC00017 ko00000,ko00001,ko00002,ko00537,ko01000,ko04147 - - - Alk_phosphatase,SWM_repeat SRD1_k127_4345415_0 1379698.RBG1_1C00001G0607 9.195e-160 532.0 COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2NQNE@2323|unclassified Bacteria 2|Bacteria T Serine threonine protein kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PASTA,Pkinase,TPR_2,TPR_8 SRD1_k127_4345415_2 1123075.AUDP01000025_gene372 2.234e-07 52.0 COG0407@1|root,COG0407@2|Bacteria,1VUB8@1239|Firmicutes,24JGI@186801|Clostridia 186801|Clostridia H Uroporphyrinogen decarboxylase (URO-D) - - - - - - - - - - - - URO-D SRD1_k127_4390436_1 945713.IALB_0558 2.073e-20 102.0 COG3166@1|root,COG3166@2|Bacteria 2|Bacteria NU PFAM Fimbrial assembly family protein - - - ko:K02663 - - - - ko00000,ko02035,ko02044 - - - PilN SRD1_k127_4390436_0 1121930.AQXG01000003_gene2650 3.021e-149 481.0 COG2805@1|root,COG2805@2|Bacteria 2|Bacteria NU Type II/IV secretion system protein pilT - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE SRD1_k127_4399685_4 1191523.MROS_0104 3.579e-24 104.0 COG4576@1|root,COG4576@2|Bacteria 2|Bacteria CQ ethanolamine utilization protein EutN carboxysome structural protein Ccml - - - ko:K04028,ko:K08697 - - - - ko00000 - - - EutN_CcmL SRD1_k127_4399685_2 1191523.MROS_0105 1.421e-84 286.0 COG4869@1|root,COG4869@2|Bacteria 2|Bacteria Q propanediol catabolic process - - 2.3.1.8 ko:K15024 ko00430,ko00620,ko00640,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00720,map01100,map01120,map01200 M00579 R00230,R00921 RC00004,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000 - - - PTAC SRD1_k127_4399685_3 926550.CLDAP_34840 3.844e-41 161.0 COG1349@1|root,COG1349@2|Bacteria,2G8SX@200795|Chloroflexi 200795|Chloroflexi K DeoR C terminal sensor domain - - - ko:K02081 - - - - ko00000,ko03000 - - - DeoRC,HTH_DeoR SRD1_k127_4399685_0 1328313.DS2_07733 1.114e-198 629.0 COG2407@1|root,COG2407@2|Bacteria,1R5ZQ@1224|Proteobacteria,1RNGR@1236|Gammaproteobacteria,469P5@72275|Alteromonadaceae 1236|Gammaproteobacteria G L-fucose isomerase, C-terminal domain - - 5.3.1.4 ko:K01804 ko00040,ko01100,map00040,map01100 - R01761 RC00516 ko00000,ko00001,ko01000 - - - Arabinose_Isome,Fucose_iso_C SRD1_k127_4399685_1 234267.Acid_5934 1.013e-109 359.0 COG0697@1|root,2Z7ID@2|Bacteria,3Y46C@57723|Acidobacteria 57723|Acidobacteria EG PFAM RhaT l-rhamnose-proton symport 2 - - - ko:K02856 - - - - ko00000,ko02000 2.A.7.6 - - RhaT SRD1_k127_4403707_1 857087.Metme_1173 1.377e-09 66.0 29GAR@1|root,3038K@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - SRD1_k127_4403707_0 945713.IALB_0410 1.68e-142 461.0 COG0216@1|root,COG0216@2|Bacteria 2|Bacteria J translation release factor activity prfA - - ko:K02835 - - - - ko00000,ko03012 - - - PCRF,RF-1 SRD1_k127_4410429_3 1128421.JAGA01000002_gene1496 8.012e-06 50.0 COG3875@1|root,COG3875@2|Bacteria 2|Bacteria S lactate racemase activity - - 5.1.2.1 ko:K22373 ko00620,map00620 - R01450 RC00519 ko00000,ko00001,ko01000 - - - DUF2088 SRD1_k127_4410429_0 1100721.ALKO01000032_gene137 6.554e-194 614.0 COG0362@1|root,COG0362@2|Bacteria,1MVV8@1224|Proteobacteria,2VI62@28216|Betaproteobacteria,4AD2I@80864|Comamonadaceae 28216|Betaproteobacteria H Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH gnd - 1.1.1.343,1.1.1.44 ko:K00033 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200 M00004,M00006 R01528,R10221 RC00001,RC00539 ko00000,ko00001,ko00002,ko01000 - - - 6PGD,NAD_binding_2 SRD1_k127_4410429_2 485913.Krac_2662 6.041e-83 289.0 COG1028@1|root,COG1028@2|Bacteria,2G5R0@200795|Chloroflexi 200795|Chloroflexi IQ Short-chain dehydrogenase reductase SDR - - - - - - - - - - - - adh_short,adh_short_C2 SRD1_k127_4410429_1 1442599.JAAN01000043_gene450 2.79e-147 475.0 COG2271@1|root,COG2271@2|Bacteria,1MV04@1224|Proteobacteria,1RP70@1236|Gammaproteobacteria,1X56Y@135614|Xanthomonadales 135614|Xanthomonadales G Major facilitator superfamily - - - ko:K08191 - - - - ko00000,ko02000 2.A.1.14.2 - - MFS_1 SRD1_k127_4419744_2 1123277.KB893172_gene473 4.4e-15 82.0 COG3525@1|root,COG3525@2|Bacteria,4NH2R@976|Bacteroidetes,47UPM@768503|Cytophagia 976|Bacteroidetes G Glycosyl hydrolase family 20, domain 2 - - - - - - - - - - - - Glyco_hydro_20,Glyco_hydro_20b SRD1_k127_4419744_1 649638.Trad_1840 2.519e-33 143.0 COG0823@1|root,COG0823@2|Bacteria,1WMXQ@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus U Oligogalacturonate lyase - - 4.2.2.6 ko:K01730 ko00040,map00040 - R04382 RC02124,RC02427 ko00000,ko00001,ko01000 - - - PD40,Pectate_lyase22 SRD1_k127_4419744_0 880073.Calab_3080 4.9e-145 471.0 COG0738@1|root,COG0738@2|Bacteria,2NQUK@2323|unclassified Bacteria 2|Bacteria G Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 SRD1_k127_4447472_1 880073.Calab_0291 1.899e-22 107.0 COG1596@1|root,COG1596@2|Bacteria 2|Bacteria M polysaccharide export wza - - ko:K01991 ko02026,map02026 - - - ko00000,ko00001,ko02000 1.B.18 - - Poly_export,SLBB SRD1_k127_4447472_0 880073.Calab_0292 5.875e-136 449.0 COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,2NNNP@2323|unclassified Bacteria 2|Bacteria D CobQ CobB MinD ParA nucleotide binding domain - - - ko:K16554,ko:K16692 ko05111,map05111 - - - ko00000,ko00001,ko01000,ko01001,ko02000 8.A.3.1 - - AAA_31,CbiA,GNVR,ParA,Wzz SRD1_k127_4448899_1 926550.CLDAP_34490 5.235e-20 92.0 COG1210@1|root,COG1210@2|Bacteria,2G6XV@200795|Chloroflexi 200795|Chloroflexi M PFAM Nucleotidyl transferase - - 2.7.7.9 ko:K00963 ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130 M00129,M00361,M00362,M00549 R00289 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase SRD1_k127_4448899_0 926550.CLDAP_27180 0.0 1090.0 COG4284@1|root,COG4284@2|Bacteria 2|Bacteria G Utp--glucose-1-phosphate uridylyltransferase - - 2.7.7.9 ko:K00963 ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130 M00129,M00361,M00362,M00549 R00289 RC00002 ko00000,ko00001,ko00002,ko01000 - - - UDPGP SRD1_k127_4457073_1 1235279.C772_01025 8.45e-42 161.0 COG3375@1|root,COG3375@2|Bacteria,1V21D@1239|Firmicutes,4HG3H@91061|Bacilli,26EU3@186818|Planococcaceae 91061|Bacilli S Acetyltransferase (GNAT) family - - - - - - - - - - - - Acetyltransf_1 SRD1_k127_4488353_4 945713.IALB_2247 1.368e-08 58.0 COG2208@1|root,COG2208@2|Bacteria 2|Bacteria T phosphoserine phosphatase activity - - 3.1.3.3 ko:K07315 - - - - ko00000,ko01000,ko03021 - - - SpoIIE SRD1_k127_4488353_3 1408254.T458_13475 2.192e-18 91.0 2DPKD@1|root,332HI@2|Bacteria,1VHUB@1239|Firmicutes,4IS0E@91061|Bacilli,276ZK@186822|Paenibacillaceae 91061|Bacilli - - - - - - - - - - - - - - - SRD1_k127_4488353_1 1191523.MROS_1933 9.216e-39 160.0 COG3358@1|root,COG3358@2|Bacteria 2|Bacteria S Protein of unknown function (DUF1684) - - - ko:K09164 - - - - ko00000 - - - DUF1684 SRD1_k127_4488353_2 880073.Calab_2957 4.744e-31 138.0 COG0438@1|root,COG0438@2|Bacteria,2NPA0@2323|unclassified Bacteria 2|Bacteria M glycosyl transferase group 1 - - - ko:K00754 - - - - ko00000,ko01000 - GT4 - Glyco_transf_4,Glycos_transf_1 SRD1_k127_4488353_0 518766.Rmar_2274 1.212e-53 195.0 COG1216@1|root,COG1216@2|Bacteria,4P2TY@976|Bacteroidetes 976|Bacteroidetes S Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 SRD1_k127_4492260_5 1163617.SCD_n01964 0.0001746 44.0 COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,2VJ1F@28216|Betaproteobacteria 28216|Betaproteobacteria H Belongs to the anaerobic coproporphyrinogen-III oxidase family hemN GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0051989,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 - - - - - - - - - - HemN_C,Radical_SAM SRD1_k127_4492260_4 648996.Theam_0751 1.839e-10 71.0 COG1652@1|root,COG2433@1|root,COG1652@2|Bacteria,COG2433@2|Bacteria,2G4TM@200783|Aquificae 200783|Aquificae S PFAM Peptidoglycan-binding lysin domain - - - - - - - - - - - - LysM SRD1_k127_4492260_2 517418.Ctha_1263 1.044e-80 273.0 COG1595@1|root,COG1595@2|Bacteria,1FDU7@1090|Chlorobi 1090|Chlorobi K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 SRD1_k127_4492260_3 1123399.AQVE01000024_gene2813 1.621e-35 154.0 COG4775@1|root,COG4775@2|Bacteria,1PT0R@1224|Proteobacteria,1RPWY@1236|Gammaproteobacteria 1236|Gammaproteobacteria M COG4775 Outer membrane protein protective antigen OMA87 - - - - - - - - - - - - Bac_surface_Ag,ShlB SRD1_k127_4492260_1 316067.Geob_0336 1.285e-100 342.0 COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria,1MVWY@1224|Proteobacteria,4378Y@68525|delta/epsilon subdivisions,2X2C1@28221|Deltaproteobacteria,43UD2@69541|Desulfuromonadales 28221|Deltaproteobacteria L ATP dependent DNA ligase C terminal region - - 6.5.1.1 ko:K01971 ko03450,map03450 - R00381 RC00005 ko00000,ko00001,ko01000,ko03400 - - - DNA_ligase_A_C,DNA_ligase_A_M,LigD_N SRD1_k127_4492260_0 497964.CfE428DRAFT_1168 2.232e-108 361.0 COG0661@1|root,COG0661@2|Bacteria 2|Bacteria I Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis - - - - - - - - - - - - ABC1 SRD1_k127_4499239_3 945713.IALB_2387 7.678e-22 101.0 2EKPU@1|root,33EDK@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - SRD1_k127_4499239_2 1191523.MROS_2301 5.164e-30 126.0 COG1316@1|root,COG1316@2|Bacteria 2|Bacteria K TRANSCRIPTIONal - - - - - - - - - - - - LytR_C,LytR_cpsA_psr SRD1_k127_4499239_1 517418.Ctha_0064 6.156e-36 143.0 COG0799@1|root,COG0799@2|Bacteria,1FE3F@1090|Chlorobi 1090|Chlorobi J Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation rsfS - - ko:K09710 - - - - ko00000,ko03009 - - - RsfS SRD1_k127_4499239_0 880073.Calab_1738 1.515e-202 645.0 COG0018@1|root,COG0018@2|Bacteria,2NNSE@2323|unclassified Bacteria 2|Bacteria J Arginyl tRNA synthetase N terminal dom argS GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - iAF987.Gmet_1434 Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d SRD1_k127_4499239_4 1121930.AQXG01000001_gene1460 5.366e-15 90.0 COG2911@1|root,COG3534@1|root,COG4412@1|root,COG2911@2|Bacteria,COG3534@2|Bacteria,COG4412@2|Bacteria,4NXBA@976|Bacteroidetes,1IZ5A@117747|Sphingobacteriia 976|Bacteroidetes Q alpha-L-arabinofuranosidase - - - - - - - - - - - - Invasin_D3 SRD1_k127_4533610_4 1340493.JNIF01000003_gene3054 1.255e-09 62.0 COG0823@1|root,COG0823@2|Bacteria,3Y2RC@57723|Acidobacteria 57723|Acidobacteria U WD40-like Beta Propeller - - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40,TolB_N SRD1_k127_4533610_2 880073.Calab_3071 5.808e-17 94.0 COG1361@1|root,COG1361@2|Bacteria 2|Bacteria M extracellular matrix structural constituent - - - - - - - - - - - - CHU_C,DUF11,Flg_new,SLH SRD1_k127_4533610_0 1267533.KB906738_gene2404 2.095e-138 455.0 COG4191@1|root,COG4191@2|Bacteria,3Y9CT@57723|Acidobacteria,2JP6N@204432|Acidobacteriia 204432|Acidobacteriia T Histidine kinase-like ATPases - - - - - - - - - - - - HATPase_c,cNMP_binding SRD1_k127_4533610_1 1487953.JMKF01000028_gene1369 2.894e-126 412.0 COG0492@1|root,COG3437@1|root,COG0492@2|Bacteria,COG3437@2|Bacteria,1FZX5@1117|Cyanobacteria,1HH7U@1150|Oscillatoriales 1117|Cyanobacteria KOT PFAM Pyridine nucleotide-disulphide oxidoreductase - - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2,Response_reg SRD1_k127_4536168_0 880073.Calab_0645 1.847e-133 445.0 COG3537@1|root,COG3537@2|Bacteria,2NQQ0@2323|unclassified Bacteria 2|Bacteria G Glycosyl hydrolase family 92 - - - - - - - - - - - - CHB_HEX_C_1,F5_F8_type_C,Fn3_assoc,Glyco_hydro_92 SRD1_k127_4536168_1 742725.HMPREF9450_01515 7.838e-122 405.0 COG1940@1|root,COG1940@2|Bacteria,4NFZ1@976|Bacteroidetes,2FNGN@200643|Bacteroidia,22UWS@171550|Rikenellaceae 976|Bacteroidetes GK Glucokinase glk - 2.7.1.2 ko:K00845 ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R01600,R01786 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - ROK SRD1_k127_4536168_2 945713.IALB_2729 1.029e-15 89.0 COG0760@1|root,COG0760@2|Bacteria 2|Bacteria O peptidyl-prolyl cis-trans isomerase activity - - 5.2.1.8 ko:K01802,ko:K03770 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_2,SurA_N_3 SRD1_k127_4540659_0 1382306.JNIM01000001_gene1402 4.134e-39 152.0 COG1985@1|root,COG1985@2|Bacteria,2G97Y@200795|Chloroflexi 200795|Chloroflexi H RibD C-terminal domain - - - - - - - - - - - - RibD_C SRD1_k127_4540659_1 945713.IALB_0361 1.555e-25 121.0 COG3307@1|root,COG3307@2|Bacteria 2|Bacteria M -O-antigen - - - - - - - - - - - - Wzy_C SRD1_k127_4540659_2 269799.Gmet_2651 2.285e-25 119.0 COG1408@1|root,COG1408@2|Bacteria,1MUH5@1224|Proteobacteria,42Q51@68525|delta/epsilon subdivisions,2WR0S@28221|Deltaproteobacteria,43UC0@69541|Desulfuromonadales 28221|Deltaproteobacteria S Calcineurin-like phosphoesterase superfamily domain - - - ko:K07098 - - - - ko00000 - - - Metallophos,Metallophos_2 SRD1_k127_4540659_3 1123368.AUIS01000014_gene2311 3.459e-14 74.0 COG5513@1|root,COG5513@2|Bacteria 2|Bacteria G serine-type aminopeptidase activity - - - - - - - - - - - - DUF3298,DUF4163,WG_beta_rep SRD1_k127_4546939_2 1519464.HY22_09070 6.48e-33 139.0 COG0308@1|root,COG0308@2|Bacteria 2|Bacteria E peptide catabolic process pepN1 - - - - - - - - - - - Peptidase_M1 SRD1_k127_4546939_1 945713.IALB_2378 7.827e-71 252.0 COG0697@1|root,COG0697@2|Bacteria 2|Bacteria EG spore germination pagO - - ko:K07790 ko02020,map02020 - - - ko00000,ko00001 2.A.7 - - EamA SRD1_k127_4546939_0 518766.Rmar_0251 1.242e-78 275.0 COG1159@1|root,COG1159@2|Bacteria,4NES2@976|Bacteroidetes,1FIQK@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism era - - ko:K03595 - - - - ko00000,ko03009,ko03029 - - - KH_2,MMR_HSR1 SRD1_k127_4548050_0 1047013.AQSP01000133_gene2107 8.299e-97 332.0 COG2309@1|root,COG2309@2|Bacteria 2|Bacteria E aminopeptidase activity - - - ko:K19689 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M29 SRD1_k127_4548050_3 198467.NP92_10545 1.28e-10 69.0 COG2846@1|root,COG2846@2|Bacteria,1V6W5@1239|Firmicutes,4HIWD@91061|Bacilli,21WT0@150247|Anoxybacillus 91061|Bacilli D Hemerythrin HHE cation binding domain - - - - - - - - - - - - Hemerythrin SRD1_k127_4548050_1 1150399.AQYK01000002_gene2475 6.122e-21 100.0 COG3824@1|root,COG3824@2|Bacteria,2IKXW@201174|Actinobacteria,4FTI5@85023|Microbacteriaceae 201174|Actinobacteria S Zincin-like metallopeptidase - - - - - - - - - - - - Zincin_1 SRD1_k127_4566303_0 1267535.KB906767_gene2119 2.537e-94 321.0 COG0527@1|root,COG0527@2|Bacteria,3Y34W@57723|Acidobacteria,2JHV2@204432|Acidobacteriia 204432|Acidobacteriia E Belongs to the aspartokinase family - - 2.7.2.4 ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,ACT SRD1_k127_4584283_2 926561.KB900617_gene1386 1.366e-37 145.0 COG1869@1|root,COG1869@2|Bacteria,1VA2V@1239|Firmicutes,24MPJ@186801|Clostridia,3WBVQ@53433|Halanaerobiales 186801|Clostridia G RbsD / FucU transport protein family rbsD - 5.4.99.62 ko:K06726 ko02010,map02010 - R08247 RC02247 ko00000,ko00001,ko01000 - - - RbsD_FucU SRD1_k127_4584283_4 867845.KI911784_gene3417 1.369e-24 119.0 COG2723@1|root,COG2723@2|Bacteria,2GBIH@200795|Chloroflexi,3771Z@32061|Chloroflexia 32061|Chloroflexia G 6-phospho-beta-galactosidase activity - - - - - - - - - - - - FlaA,Glyco_hydro_42,Glyco_hydro_cc SRD1_k127_4584283_5 1122925.KB895401_gene99 2.873e-13 79.0 2CAWZ@1|root,32RS9@2|Bacteria,1UPY8@1239|Firmicutes 1239|Firmicutes S Ureidoglycolate lyase - - - - - - - - - - - - Ureidogly_lyase SRD1_k127_4584283_3 1536769.P40081_32880 7.526e-32 142.0 COG1649@1|root,COG1649@2|Bacteria 2|Bacteria F PFAM Uncharacterised BCR, COG1649 - - 3.2.1.11 ko:K05988 ko00500,map00500 - R11309 - ko00000,ko00001,ko01000 - GH66 - CBM_35,CBM_6,GHL10,Glyco_hydro_66,Polysacc_deac_1,Ricin_B_lectin,SLH SRD1_k127_4584283_0 861299.J421_5643 4.593e-159 510.0 COG0673@1|root,COG0673@2|Bacteria,1ZU84@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C SRD1_k127_4584283_1 273068.TTE1948 3.364e-111 367.0 COG1082@1|root,COG1082@2|Bacteria,1TPJT@1239|Firmicutes,24A6G@186801|Clostridia,42FEK@68295|Thermoanaerobacterales 186801|Clostridia G PFAM Xylose isomerase - - - - - - - - - - - - AP_endonuc_2,AP_endonuc_2_N SRD1_k127_4584283_6 1536775.H70737_15025 1.078e-11 66.0 COG1874@1|root,COG1874@2|Bacteria,1U3F2@1239|Firmicutes,4IC6E@91061|Bacilli,271AT@186822|Paenibacillaceae 91061|Bacilli G Glycosyl hydrolases family 35 - - 3.2.1.23 ko:K12308 ko00052,map00052 - R01105 RC00452 ko00000,ko00001,ko01000 - - - Glyco_hydro_42,Glyco_hydro_42M SRD1_k127_4593139_5 714943.Mucpa_2698 8.118e-22 97.0 COG0439@1|root,COG0439@2|Bacteria,4NFEQ@976|Bacteroidetes,1INM0@117747|Sphingobacteriia 976|Bacteroidetes I acetyl-CoA carboxylase, biotin carboxylase accC - 6.3.4.14,6.4.1.2 ko:K01961 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 SRD1_k127_4593139_4 945713.IALB_0807 4.47e-41 157.0 COG0511@1|root,COG0511@2|Bacteria 2|Bacteria I ligase activity, forming carbon-carbon bonds accB - 2.3.1.12,4.1.1.3 ko:K00627,ko:K01571,ko:K02160 ko00010,ko00020,ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00010,map00020,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00307,M00376 R00209,R00217,R00742,R02569 RC00004,RC00040,RC00367,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000,ko02000 3.B.1.1.1 - iHN637.CLJU_RS20755 Biotin_lipoyl SRD1_k127_4593139_2 945713.IALB_0806 5.874e-67 232.0 COG0231@1|root,COG0231@2|Bacteria 2|Bacteria J translation elongation factor activity efp GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02356 - - - - ko00000,ko03012 - - - EFP,EFP_N,Elong-fact-P_C SRD1_k127_4593139_0 1519464.HY22_02910 3.345e-123 405.0 COG0150@1|root,COG0150@2|Bacteria,1FDK2@1090|Chlorobi 1090|Chlorobi F AIR synthase related protein domain protein purM - 6.3.3.1 ko:K01933 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04208 RC01100 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C SRD1_k127_4593139_1 243231.GSU0585 2.411e-70 246.0 COG0179@1|root,COG0179@2|Bacteria,1MVFA@1224|Proteobacteria,42S7E@68525|delta/epsilon subdivisions,2WKJ0@28221|Deltaproteobacteria,43SDP@69541|Desulfuromonadales 28221|Deltaproteobacteria Q Fumarylacetoacetate (FAA) hydrolase family ycgM - 3.7.1.20 ko:K16165 ko00350,ko01100,ko01120,map00350,map01100,map01120 - R01085 RC00326,RC00446 ko00000,ko00001,ko01000 - - - FAA_hydrolase SRD1_k127_4593139_3 509635.N824_06225 1.929e-52 203.0 COG0739@1|root,COG0739@2|Bacteria,4NED7@976|Bacteroidetes,1INUW@117747|Sphingobacteriia 976|Bacteroidetes M Peptidase, M23 - - - - - - - - - - - - Peptidase_M23 SRD1_k127_461599_2 313628.LNTAR_08634 2.506e-44 164.0 COG1028@1|root,COG1028@2|Bacteria 313628.LNTAR_08634|- IQ oxidoreductase activity, acting on CH-OH group of donors - - - - - - - - - - - - - SRD1_k127_461599_0 452637.Oter_2883 3.496e-201 635.0 COG4225@1|root,COG4225@2|Bacteria,46SGW@74201|Verrucomicrobia,3K7PS@414999|Opitutae 414999|Opitutae S Glycosyl Hydrolase Family 88 - - - - - - - - - - - - Glyco_hydro_88 SRD1_k127_461599_1 1047013.AQSP01000131_gene1828 4.881e-47 181.0 COG1595@1|root,COG1595@2|Bacteria,2NPVV@2323|unclassified Bacteria 2|Bacteria K GxGYxYP putative glycoside hydrolase C-terminal domain - - - ko:K03088 - - - - ko00000,ko03021 - - - GxGYxYP_C,GxGYxYP_N,Inovirus_Gp2,Sigma70_r4_2 SRD1_k127_4616120_0 211165.AJLN01000109_gene152 1.316e-143 464.0 COG3259@1|root,COG3259@2|Bacteria,1G1C8@1117|Cyanobacteria,1JK5U@1189|Stigonemataceae 1117|Cyanobacteria C Nickel-dependent hydrogenase hoxH - 1.12.1.2 ko:K00436 - - R00700 - ko00000,ko01000 - - iJN678.hoxH NiFeSe_Hases SRD1_k127_4616120_2 1173025.GEI7407_1929 1.404e-22 104.0 COG0680@1|root,COG0680@2|Bacteria,1G7PP@1117|Cyanobacteria,1HC58@1150|Oscillatoriales 1117|Cyanobacteria C hydrogenase maturation protease - - - - - - - - - - - - - SRD1_k127_4616120_1 1121930.AQXG01000001_gene1216 2.994e-24 105.0 COG4409@1|root,COG4409@2|Bacteria 2|Bacteria G exo-alpha-(2->6)-sialidase activity - - 3.2.1.18 ko:K01186 ko00511,ko00600,ko04142,map00511,map00600,map04142 - R04018 RC00028,RC00077 ko00000,ko00001,ko01000,ko02042 - GH33 - BNR_2,Beta_helix,F5_F8_type_C SRD1_k127_4622608_0 1519464.HY22_09955 7.94e-62 218.0 COG0823@1|root,COG4775@1|root,COG0823@2|Bacteria,COG4775@2|Bacteria,1FEV1@1090|Chlorobi 1090|Chlorobi MU WD40-like Beta Propeller Repeat - - - - - - - - - - - - PD40 SRD1_k127_4622608_1 945713.IALB_1372 2.927e-35 150.0 COG1520@1|root,COG4412@1|root,COG1520@2|Bacteria,COG4412@2|Bacteria 2|Bacteria S peptidase activity, acting on L-amino acid peptides - - - - - - - - - - - - Big_2,HATPase_c,PQQ_2,PQQ_3,Peptidase_C25,SLH,Y_Y_Y SRD1_k127_4624210_0 765420.OSCT_3169 1.734e-118 394.0 COG0260@1|root,COG0260@2|Bacteria,2G617@200795|Chloroflexi,37528@32061|Chloroflexia 32061|Chloroflexia E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides pepA - 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M17,Peptidase_M17_N SRD1_k127_4624210_1 1121930.AQXG01000003_gene2634 2.224e-33 145.0 COG4219@1|root,COG4219@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - Amidase_6,DUF4309,DUF5301 SRD1_k127_4639560_0 518766.Rmar_0001 1.057e-152 496.0 COG0593@1|root,COG0593@2|Bacteria,4NE6Q@976|Bacteroidetes,1FITM@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids dnaA GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837 - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C,DnaA_N SRD1_k127_4639560_3 1313301.AUGC01000001_gene1635 1.139e-13 76.0 COG0230@1|root,COG0230@2|Bacteria,4NUTV@976|Bacteroidetes 976|Bacteroidetes J Belongs to the bacterial ribosomal protein bL34 family rpmH - - ko:K02914 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L34 SRD1_k127_4639560_4 1157490.EL26_22050 8.19e-06 53.0 COG0594@1|root,COG0594@2|Bacteria,1VA78@1239|Firmicutes,4HKG6@91061|Bacilli,278N4@186823|Alicyclobacillaceae 91061|Bacilli J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme rnpA GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0031123,GO:0031404,GO:0032991,GO:0033204,GO:0034414,GO:0034470,GO:0034641,GO:0034660,GO:0042301,GO:0042779,GO:0042780,GO:0042781,GO:0043167,GO:0043168,GO:0043170,GO:0043199,GO:0043628,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901681,GO:1902494,GO:1902555,GO:1905267,GO:1905348,GO:1990904 3.1.26.5 ko:K03536 - - - - ko00000,ko01000,ko03016 - - - Ribonuclease_P SRD1_k127_4639560_2 313612.L8106_03439 1.899e-22 107.0 COG0759@1|root,COG0759@2|Bacteria,1G90B@1117|Cyanobacteria,1HCVK@1150|Oscillatoriales 1117|Cyanobacteria S Could be involved in insertion of integral membrane proteins into the membrane - - - ko:K08998 - - - - ko00000 - - - Haemolytic SRD1_k127_4639560_1 194439.CT0006 1.478e-42 168.0 COG0706@1|root,COG0706@2|Bacteria,1FDGH@1090|Chlorobi 1090|Chlorobi U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins yidC - - ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 - - 60KD_IMP,YidC_periplas SRD1_k127_4639995_1 1123248.KB893343_gene13 8.417e-41 154.0 COG3795@1|root,COG3795@2|Bacteria,4NV45@976|Bacteroidetes 976|Bacteroidetes S YCII-related domain - - - - - - - - - - - - YCII SRD1_k127_4639995_3 521011.Mpal_2556 2.079e-32 133.0 arCOG06069@1|root,arCOG06069@2157|Archaea,2Y06E@28890|Euryarchaeota,2NB1K@224756|Methanomicrobia 224756|Methanomicrobia S Putative redox-active protein (C_GCAxxG_C_C) - - - - - - - - - - - - C_GCAxxG_C_C SRD1_k127_4639995_5 575540.Isop_3669 8.929e-10 70.0 COG0863@1|root,COG1475@1|root,COG0863@2|Bacteria,COG1475@2|Bacteria,2J1FN@203682|Planctomycetes 203682|Planctomycetes KL Belongs to the N(4) N(6)-methyltransferase family - - - - - - - - - - - - N6_N4_Mtase,ParBc SRD1_k127_4639995_0 1121904.ARBP01000009_gene4139 4.81e-48 189.0 COG2304@1|root,COG2304@2|Bacteria,4NIM2@976|Bacteroidetes,47UJI@768503|Cytophagia 976|Bacteroidetes S von Willebrand factor type A domain - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - VWA SRD1_k127_4639995_4 926560.KE387026_gene4250 1.205e-30 128.0 2DEWP@1|root,2ZPJE@2|Bacteria 2|Bacteria S DinB family - - - - - - - - - - - - DinB SRD1_k127_4639995_2 1047013.AQSP01000122_gene2224 5.465e-35 152.0 COG3291@1|root,COG5434@1|root,COG3291@2|Bacteria,COG5434@2|Bacteria,2NQ6Y@2323|unclassified Bacteria 2|Bacteria M PKD domain - - 3.2.1.157,3.2.1.91 ko:K19668,ko:K20850 ko00500,ko01100,ko02020,map00500,map01100,map02020 - R02886,R11308 RC00799 ko00000,ko00001,ko01000 - GH6,GH82 - Beta_helix,CHU_C,Cadherin-like,FlgD_ig,PKD,Pectate_lyase_3 SRD1_k127_4650924_2 945713.IALB_1970 3.115e-15 83.0 COG1216@1|root,COG1216@2|Bacteria 2|Bacteria V Glycosyl transferase, family 2 wgeF - - - - - - - - - - - GT87 SRD1_k127_4650924_0 1123253.AUBD01000008_gene420 9.954e-42 158.0 COG0599@1|root,COG0599@2|Bacteria,1N38Z@1224|Proteobacteria,1S5G6@1236|Gammaproteobacteria,1X6C8@135614|Xanthomonadales 135614|Xanthomonadales S Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - - - - - - - - - - CMD SRD1_k127_4650924_1 706587.Desti_0559 6.453e-41 160.0 COG1225@1|root,COG1225@2|Bacteria,1NZF4@1224|Proteobacteria,42ZRX@68525|delta/epsilon subdivisions 1224|Proteobacteria O Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - - - - - - - - - - - SRD1_k127_4656855_3 867903.ThesuDRAFT_01825 3.523e-71 246.0 COG1840@1|root,COG1840@2|Bacteria,1TQC3@1239|Firmicutes,24JZS@186801|Clostridia 186801|Clostridia P solute-binding protein - - - ko:K02012 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko02000 3.A.1.10 - - SBP_bac_6 SRD1_k127_4656855_2 644966.Tmar_0709 9.374e-84 299.0 COG3842@1|root,COG3842@2|Bacteria,1TP2M@1239|Firmicutes,247JR@186801|Clostridia,3WCDT@538999|Clostridiales incertae sedis 186801|Clostridia P Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system potA - 3.6.3.30,3.6.3.31 ko:K02010,ko:K11072 ko02010,map02010 M00190,M00299 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.10,3.A.1.11.1 - - ABC_tran,TOBE_2 SRD1_k127_4656855_0 997346.HMPREF9374_2151 2.302e-122 413.0 COG1178@1|root,COG1178@2|Bacteria,1TPMX@1239|Firmicutes,4HA2U@91061|Bacilli,27CKY@186824|Thermoactinomycetaceae 91061|Bacilli P Binding-protein-dependent transport system inner membrane component - - - ko:K02011 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko02000 3.A.1.10 - - BPD_transp_1 SRD1_k127_4656855_5 1150469.RSPPHO_02781 0.0004631 45.0 COG2165@1|root,COG2165@2|Bacteria,1PJ5F@1224|Proteobacteria,2VC7I@28211|Alphaproteobacteria,2JY2W@204441|Rhodospirillales 204441|Rhodospirillales NU general secretion pathway protein - - - - - - - - - - - - - SRD1_k127_4656855_4 643867.Ftrac_2509 6.561e-15 83.0 COG1729@1|root,COG1729@2|Bacteria,4NEM2@976|Bacteroidetes,47PPQ@768503|Cytophagia 976|Bacteroidetes S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_21,TPR_6,TPR_7,TPR_8 SRD1_k127_4656855_1 1191523.MROS_1857 7.209e-106 370.0 COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria 2|Bacteria T phosphoserine phosphatase activity rsbU - 3.1.3.3 ko:K07315 - - - - ko00000,ko01000,ko03021 - - - GAF_2,GAF_3,SpoIIE SRD1_k127_468294_0 1122947.FR7_0621 1.253e-280 897.0 COG0841@1|root,COG0841@2|Bacteria,1TQ03@1239|Firmicutes,4H20U@909932|Negativicutes 909932|Negativicutes V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran SRD1_k127_468294_2 385682.AFSL01000084_gene1102 2.389e-10 66.0 COG0347@1|root,COG0347@2|Bacteria,4NSBG@976|Bacteroidetes,2FT39@200643|Bacteroidia,3XK9K@558415|Marinilabiliaceae 976|Bacteroidetes E COG NOG19114 non supervised orthologous group - - - - - - - - - - - - - SRD1_k127_468294_1 1131462.DCF50_p1700 6.593e-13 71.0 COG1832@1|root,COG1832@2|Bacteria,1V7C7@1239|Firmicutes,24P0N@186801|Clostridia,2632C@186807|Peptococcaceae 186801|Clostridia S CoA-binding protein - - - ko:K06929 - - - - ko00000 - - - CoA_binding_2 SRD1_k127_4684463_1 515635.Dtur_1544 7.232e-92 316.0 COG1641@1|root,COG1641@2|Bacteria 2|Bacteria H Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes larC - 4.99.1.12 ko:K06898,ko:K09121 - - - - ko00000,ko01000 - - - DUF111 SRD1_k127_4684463_0 234267.Acid_1539 3.682e-178 574.0 COG0457@1|root,COG0457@2|Bacteria,3Y3PD@57723|Acidobacteria 57723|Acidobacteria S Peptidase family M49 - - - - - - - - - - - - Peptidase_M49 SRD1_k127_4684463_2 317936.Nos7107_4497 1.096e-54 196.0 COG4221@1|root,COG4221@2|Bacteria,1G182@1117|Cyanobacteria,1HICK@1161|Nostocales 1117|Cyanobacteria S Belongs to the short-chain dehydrogenases reductases (SDR) family - - 1.1.1.276 ko:K05886 - - - - ko00000,ko01000 - - - adh_short SRD1_k127_4690999_5 945713.IALB_0639 5.452e-11 72.0 COG0532@1|root,COG0532@2|Bacteria 2|Bacteria J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N SRD1_k127_4690999_0 755732.Fluta_1866 5.106e-120 401.0 COG0195@1|root,COG0195@2|Bacteria,4NFGA@976|Bacteroidetes,1HY37@117743|Flavobacteriia,2PAGI@246874|Cryomorphaceae 976|Bacteroidetes K Participates in both transcription termination and antitermination nusA - - ko:K02600 - - - - ko00000,ko03009,ko03021 - - - KH_5,NusA_N,S1 SRD1_k127_4690999_3 309807.SRU_1779 4.981e-26 113.0 COG0779@1|root,COG0779@2|Bacteria,4PERI@976|Bacteroidetes,1FJH2@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes J Required for maturation of 30S ribosomal subunits rimP - - ko:K09748 - - - - ko00000,ko03009 - - - DUF150,DUF150_C SRD1_k127_4690999_4 330214.NIDE4308 7.198e-15 83.0 COG0824@1|root,COG0824@2|Bacteria,3J1EV@40117|Nitrospirae 40117|Nitrospirae S Thioesterase-like superfamily - - - ko:K07107 - - - - ko00000,ko01000 - - - 4HBT SRD1_k127_4690999_1 518766.Rmar_1115 3.939e-113 377.0 COG2008@1|root,COG2008@2|Bacteria,4NEIH@976|Bacteroidetes,1FIQX@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes E Beta-eliminating lyase - - 4.1.2.48 ko:K01620 ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230 - R00751,R06171 RC00312,RC00372 ko00000,ko00001,ko01000 - - - Beta_elim_lyase SRD1_k127_4690999_2 945713.IALB_2260 2.999e-81 288.0 COG0815@1|root,COG0815@2|Bacteria 2|Bacteria M Transfers the fatty acyl group on membrane lipoproteins lnt - - ko:K03820 - - - - ko00000,ko01000 - GT2 - CN_hydrolase SRD1_k127_4711071_0 661478.OP10G_1273 9.938e-145 474.0 COG3250@1|root,COG3250@2|Bacteria 2|Bacteria G beta-galactosidase activity - - 3.2.1.40 ko:K05989 - - - - ko00000,ko01000 - - - Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N,Lyase_8,Lyase_8_C,Lyase_8_N,NPCBM_assoc SRD1_k127_4711071_1 742725.HMPREF9450_00783 8.861e-106 359.0 COG2152@1|root,COG2152@2|Bacteria,4P1IV@976|Bacteroidetes 976|Bacteroidetes G Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose - - - - - - - - - - - - - SRD1_k127_4711071_2 1270196.JCKI01000006_gene2535 6.251e-38 149.0 COG3667@1|root,COG3667@2|Bacteria,4NICY@976|Bacteroidetes,1IWVR@117747|Sphingobacteriia 976|Bacteroidetes P copper resistance - - - - - - - - - - - - - SRD1_k127_473519_0 945713.IALB_0844 8.884e-303 942.0 COG0046@1|root,COG0046@2|Bacteria 2|Bacteria F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purL GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004642,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C SRD1_k127_473519_3 483219.LILAB_11185 4.492e-36 154.0 COG2067@1|root,COG2067@2|Bacteria,1MUU4@1224|Proteobacteria,42N9J@68525|delta/epsilon subdivisions,2WK7H@28221|Deltaproteobacteria,2YXMU@29|Myxococcales 28221|Deltaproteobacteria I Long-chain fatty acid transport protein - - - ko:K06076 - - - - ko00000,ko02000 1.B.9 - - Toluene_X SRD1_k127_473519_5 926550.CLDAP_21640 5.587e-13 76.0 COG4770@1|root,COG4770@2|Bacteria 2|Bacteria I CoA carboxylase activity pccA - 6.4.1.3 ko:K01965,ko:K02160 ko00061,ko00280,ko00620,ko00630,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00620,map00630,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00373,M00376,M00741 R00742,R01859 RC00040,RC00097,RC00367,RC00609 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2 SRD1_k127_473519_4 1089550.ATTH01000001_gene1605 1.431e-13 74.0 COG0439@1|root,COG0439@2|Bacteria,4NFEQ@976|Bacteroidetes,1FJSH@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes I Pfam:CPSase_L_chain accC - 6.3.4.14,6.4.1.2,6.4.1.3 ko:K01961,ko:K01965 ko00061,ko00280,ko00620,ko00630,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00620,map00630,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00373,M00376,M00741 R00742,R01859,R04385 RC00040,RC00097,RC00253,RC00367,RC00609 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 SRD1_k127_473519_1 880073.Calab_2210 1.563e-156 504.0 COG0439@1|root,COG0439@2|Bacteria,2NNKD@2323|unclassified Bacteria 2|Bacteria I carboxylase, biotin carboxylase pccA - 6.3.4.14,6.4.1.2,6.4.1.3,6.4.1.4 ko:K01961,ko:K01968,ko:K11263 ko00061,ko00280,ko00620,ko00630,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00620,map00630,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00036,M00082,M00376,M00741 R00742,R01859,R04138,R04385 RC00040,RC00097,RC00253,RC00367,RC00609,RC00942 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2 SRD1_k127_473519_2 1519464.HY22_12205 2.775e-130 434.0 COG1193@1|root,COG1193@2|Bacteria,1FDBB@1090|Chlorobi 1090|Chlorobi L Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity mutS2 - - ko:K07456 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_V,Smr SRD1_k127_4740315_1 945713.IALB_2662 1.256e-55 205.0 COG1807@1|root,COG1807@2|Bacteria 2|Bacteria M 4-amino-4-deoxy-L-arabinose transferase activity - - - - - - - - - - - - DUF2723,PMT,PMT_2,TPR_19 SRD1_k127_4740315_0 877418.ATWV01000005_gene2633 1.094e-73 255.0 COG0800@1|root,COG0800@2|Bacteria,2J6B8@203691|Spirochaetes 203691|Spirochaetes G PFAM KDPG and KHG aldolase - - 4.1.2.14,4.1.3.42 ko:K01625 ko00030,ko00630,ko01100,ko01120,ko01200,map00030,map00630,map01100,map01120,map01200 M00008,M00061,M00308,M00631 R00470,R05605 RC00307,RC00308,RC00435 ko00000,ko00001,ko00002,ko01000 - - - Aldolase SRD1_k127_4761109_0 1089550.ATTH01000001_gene1513 5.186e-125 410.0 COG0482@1|root,COG0482@2|Bacteria,4NFXZ@976|Bacteroidetes,1FISU@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 mnmA - 2.8.1.13 ko:K00566 ko04122,map04122 - R08700 RC02313,RC02315 ko00000,ko00001,ko01000,ko03016 - - - tRNA_Me_trans SRD1_k127_4761109_1 1089547.KB913013_gene4784 4.442e-50 186.0 COG1670@1|root,COG1670@2|Bacteria,4NR1U@976|Bacteroidetes,47UC9@768503|Cytophagia 976|Bacteroidetes J Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_3 SRD1_k127_4772521_2 1267535.KB906767_gene5166 1.256e-23 104.0 COG4299@1|root,COG4299@2|Bacteria,3Y2J9@57723|Acidobacteria 57723|Acidobacteria S COGs COG4299 conserved - - - - - - - - - - - - DUF1624,DUF5009 SRD1_k127_4772521_0 1408473.JHXO01000001_gene2492 1.081e-147 480.0 COG2385@1|root,COG2385@2|Bacteria,4NG21@976|Bacteroidetes,2FP4W@200643|Bacteroidia 976|Bacteroidetes D SpoIID LytB domain protein lytB - - ko:K06381 - - - - ko00000 - - - DUF4922,Glycos_transf_2,SpoIID SRD1_k127_4772521_1 234267.Acid_1664 1.083e-27 114.0 COG0577@1|root,COG0577@2|Bacteria,3Y2YA@57723|Acidobacteria 57723|Acidobacteria V MacB-like periplasmic core domain - - - - - - - - - - - - FtsX,MacB_PCD SRD1_k127_4813198_1 518766.Rmar_2608 1.699e-130 450.0 COG2812@1|root,COG5512@1|root,COG2812@2|Bacteria,COG5512@2|Bacteria,4NE8A@976|Bacteroidetes,1FJ3G@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity dnaX - 2.7.7.7 ko:K02343 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2,DNA_pol3_gamma3 SRD1_k127_4813198_0 370438.PTH_0807 2.291e-253 805.0 COG0466@1|root,COG0466@2|Bacteria,1TNYG@1239|Firmicutes,247SH@186801|Clostridia,260BY@186807|Peptococcaceae 186801|Clostridia O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C SRD1_k127_4813198_2 351607.Acel_0539 1.523e-05 56.0 COG5662@1|root,COG5662@2|Bacteria,2IM2X@201174|Actinobacteria,4ETFE@85013|Frankiales 201174|Actinobacteria K anti-sigma factor rsrA GO:0000988,GO:0000989,GO:0003674,GO:0005488,GO:0006950,GO:0006979,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009593,GO:0009628,GO:0009889,GO:0010556,GO:0016989,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0032502,GO:0042221,GO:0043167,GO:0043169,GO:0043934,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051606,GO:0051775,GO:0051776,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2001141 - - - - - - - - - - zf-HC2 SRD1_k127_4821445_5 927658.AJUM01000034_gene567 4.129e-37 160.0 29X8I@1|root,30IXV@2|Bacteria,4P0MB@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - SRD1_k127_4821445_3 903818.KI912268_gene1661 4.215e-39 164.0 COG0535@1|root,COG0535@2|Bacteria,3Y40T@57723|Acidobacteria 57723|Acidobacteria S Iron-sulfur cluster-binding domain pqqE - - ko:K06139 - - - - ko00000 - - - Fer4_12,Radical_SAM,SPASM SRD1_k127_4821445_0 96561.Dole_2461 2.484e-122 405.0 COG0535@1|root,COG0535@2|Bacteria,1PNW8@1224|Proteobacteria,42YG5@68525|delta/epsilon subdivisions,2WTXF@28221|Deltaproteobacteria 28221|Deltaproteobacteria M PFAM Radical SAM - - - - - - - - - - - - Fer4_12,Fer4_14,Radical_SAM SRD1_k127_4821445_1 96561.Dole_2461 4.729e-121 402.0 COG0535@1|root,COG0535@2|Bacteria,1PNW8@1224|Proteobacteria,42YG5@68525|delta/epsilon subdivisions,2WTXF@28221|Deltaproteobacteria 28221|Deltaproteobacteria M PFAM Radical SAM - - - - - - - - - - - - Fer4_12,Fer4_14,Radical_SAM SRD1_k127_4821445_2 1047013.AQSP01000115_gene352 4.537e-109 368.0 COG0454@1|root,COG0456@2|Bacteria,2NNUP@2323|unclassified Bacteria 2|Bacteria K acetyltransferase - - - - - - - - - - - - - SRD1_k127_4821445_4 1191523.MROS_0749 2.2e-37 147.0 COG0535@1|root,COG0535@2|Bacteria 2|Bacteria I radical SAM domain protein - - - - - - - - - - - - Fer4_12,Fer4_14,Radical_SAM,SPASM SRD1_k127_4861473_1 1047013.AQSP01000139_gene2343 2.247e-65 228.0 COG2080@1|root,COG2080@2|Bacteria,2NPPX@2323|unclassified Bacteria 2|Bacteria C PFAM 2Fe-2S -binding - - 1.2.5.3,1.3.99.16 ko:K03518,ko:K07302,ko:K13483 ko00230,ko01100,ko01120,map00230,map01100,map01120 M00546 R01768,R02103,R11168 RC00143,RC02800 ko00000,ko00001,ko00002,ko01000 - - - Fer2,Fer2_2 SRD1_k127_4861473_0 1047013.AQSP01000139_gene2342 1.412e-176 567.0 COG1529@1|root,COG1529@2|Bacteria,2NPHP@2323|unclassified Bacteria 2|Bacteria C Aldehyde oxidase and xanthine dehydrogenase, a b hammerhead - - 1.17.1.4 ko:K11177 ko00230,ko01100,ko01120,map00230,map01100,map01120 M00546 R01768,R02103 RC00143 ko00000,ko00001,ko00002,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 SRD1_k127_491745_0 1191523.MROS_2549 1.393e-134 437.0 COG1190@1|root,COG1190@2|Bacteria 2|Bacteria J Belongs to the class-II aminoacyl-tRNA synthetase family lysS - 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DUF4332,tRNA-synt_2,tRNA_anti-codon SRD1_k127_491745_6 1121004.ATVC01000013_gene2055 4.137e-47 173.0 COG0824@1|root,COG0824@2|Bacteria,1RF7Q@1224|Proteobacteria,2VR5T@28216|Betaproteobacteria,2KRGT@206351|Neisseriales 206351|Neisseriales S thioesterase K01075 - - - - - - - - - - - - 4HBT_2 SRD1_k127_491745_10 344747.PM8797T_23736 4.414e-32 131.0 COG0597@1|root,COG0597@2|Bacteria,2J3XC@203682|Planctomycetes 203682|Planctomycetes M Signal peptidase (SPase) II - - - - - - - - - - - - Peptidase_A8 SRD1_k127_491745_3 1237149.C900_02736 1.398e-65 237.0 COG1512@1|root,COG1512@2|Bacteria,4NF4P@976|Bacteroidetes,47NDD@768503|Cytophagia 976|Bacteroidetes S Beta-propeller domains of methanol dehydrogenase type - - - ko:K06872 - - - - ko00000 - - - TPM_phosphatase SRD1_k127_491745_7 1237149.C900_03153 9.757e-42 162.0 COG3762@1|root,COG3762@2|Bacteria 2|Bacteria S Membrane - - - ko:K08988 - - - - ko00000 - - - TPM_phosphatase SRD1_k127_491745_8 1173025.GEI7407_0976 7.634e-35 136.0 COG0662@1|root,COG0662@2|Bacteria,1GQC8@1117|Cyanobacteria,1HI5D@1150|Oscillatoriales 1117|Cyanobacteria G PFAM Cupin 2, conserved barrel - - - ko:K11312 - - - - ko00000 - - - Cupin_2,Nif11 SRD1_k127_491745_5 1192034.CAP_7231 3.843e-48 184.0 COG0454@1|root,COG0456@2|Bacteria,1RKSW@1224|Proteobacteria,438AQ@68525|delta/epsilon subdivisions,2X3K1@28221|Deltaproteobacteria,2YWDB@29|Myxococcales 28221|Deltaproteobacteria K acetyltransferase - - - - - - - - - - - - - SRD1_k127_491745_1 945713.IALB_2753 4.875e-73 259.0 COG0265@1|root,COG0265@2|Bacteria 2|Bacteria O serine-type endopeptidase activity - - - ko:K09973 - - - - ko00000 - - - TPR_11,TPR_16,TPR_8,Trypsin_2 SRD1_k127_491745_2 385682.AFSL01000005_gene973 7.342e-66 234.0 COG1187@1|root,COG1187@2|Bacteria,4NEE1@976|Bacteroidetes,2FP7M@200643|Bacteroidia,3XIPU@558415|Marinilabiliaceae 976|Bacteroidetes J S4 RNA-binding domain rluB - 5.4.99.22 ko:K06178 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 SRD1_k127_491745_4 945713.IALB_1558 7.574e-49 184.0 COG1386@1|root,COG1386@2|Bacteria 2|Bacteria D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves scpB GO:0003674,GO:0005488,GO:0005515,GO:0042802 - ko:K06024 - - - - ko00000,ko03036 - - - SMC_ScpB SRD1_k127_491745_9 204669.Acid345_4495 2.786e-33 130.0 COG2027@1|root,COG2027@2|Bacteria,3Y3WF@57723|Acidobacteria,2JIBN@204432|Acidobacteriia 204432|Acidobacteriia M PFAM Peptidase S13, D-Ala-D-Ala carboxypeptidase C - - 3.4.16.4 ko:K07259 ko00550,map00550 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - Peptidase_S13 SRD1_k127_4923192_2 933262.AXAM01000213_gene1883 5.799e-22 95.0 2DN2Z@1|root,32V89@2|Bacteria,1N3VG@1224|Proteobacteria,42TI7@68525|delta/epsilon subdivisions,2WQNX@28221|Deltaproteobacteria,2MKM9@213118|Desulfobacterales 28221|Deltaproteobacteria S zinc-ribbon domain - - - - - - - - - - - - zf-ribbon_3 SRD1_k127_4923192_1 398767.Glov_1586 1.097e-49 185.0 COG0727@1|root,COG0727@2|Bacteria,1RCAS@1224|Proteobacteria,432RR@68525|delta/epsilon subdivisions,2WX9R@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Putative zinc- or iron-chelating domain - - - - - - - - - - - - CxxCxxCC SRD1_k127_4923192_0 316067.Geob_0567 1.722e-152 490.0 COG0500@1|root,COG0500@2|Bacteria,1QW86@1224|Proteobacteria,42N1Q@68525|delta/epsilon subdivisions,2WJJS@28221|Deltaproteobacteria,43TSG@69541|Desulfuromonadales 28221|Deltaproteobacteria Q Dimerisation domain - - - - - - - - - - - - Dimerisation2,Methyltransf_2 SRD1_k127_4923192_3 269799.Gmet_2807 4.399e-06 49.0 COG1661@1|root,COG1661@2|Bacteria,1RIUJ@1224|Proteobacteria,42SC0@68525|delta/epsilon subdivisions,2WPPG@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Domain of unknown function (DUF296) - - - - - - - - - - - - DUF296 SRD1_k127_4923342_4 1210884.HG799462_gene8906 5.499e-15 85.0 COG4447@1|root,COG4447@2|Bacteria,2IXMV@203682|Planctomycetes 203682|Planctomycetes S to plant photosystem II stability assembly factor - - - - - - - - - - - - PSII_BNR SRD1_k127_4923342_2 1379698.RBG1_1C00001G0290 2.815e-145 489.0 COG0308@1|root,COG0308@2|Bacteria,2NPGQ@2323|unclassified Bacteria 2|Bacteria E aminopeptidase - - - - - - - - - - - - BPD_transp_1,PD40,Peptidase_M1 SRD1_k127_4923342_0 1191523.MROS_2396 7.684e-211 685.0 COG1452@1|root,COG1452@2|Bacteria 2|Bacteria M lipopolysaccharide transport - - - - - - - - - - - - - SRD1_k127_4923342_1 517417.Cpar_1316 2.427e-152 494.0 COG2256@1|root,COG2256@2|Bacteria,1FDKB@1090|Chlorobi 1090|Chlorobi L PFAM AAA ATPase central domain protein - - - ko:K07478 - - - - ko00000 - - - AAA,AAA_assoc_2,MgsA_C SRD1_k127_4923342_5 316067.Geob_2927 0.0001851 48.0 COG2919@1|root,COG2919@2|Bacteria,1NM5U@1224|Proteobacteria,42X2K@68525|delta/epsilon subdivisions,2WSPM@28221|Deltaproteobacteria,43VHG@69541|Desulfuromonadales 28221|Deltaproteobacteria D Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic divIC - - ko:K05589,ko:K13052 - - - - ko00000,ko03036 - - - DivIC SRD1_k127_4923342_3 1121430.JMLG01000013_gene1877 1.418e-71 246.0 COG1181@1|root,COG1181@2|Bacteria,1TP2Y@1239|Firmicutes,248CR@186801|Clostridia,26106@186807|Peptococcaceae 186801|Clostridia F Belongs to the D-alanine--D-alanine ligase family ddl - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C,Dala_Dala_lig_N SRD1_k127_4927851_0 56110.Oscil6304_0196 1.756e-42 165.0 COG0500@1|root,COG2226@2|Bacteria,1G681@1117|Cyanobacteria,1HBRE@1150|Oscillatoriales 1117|Cyanobacteria Q Methyltransferase domain - - - - - - - - - - - - Methyltransf_11,Methyltransf_23,TPR_11,TPR_2 SRD1_k127_4927851_1 673860.AciM339_0792 1.829e-17 91.0 COG0438@1|root,arCOG01411@2157|Archaea,2Y3MP@28890|Euryarchaeota 28890|Euryarchaeota M Glycosyltransferase Family 4 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 SRD1_k127_4928543_1 518766.Rmar_2818 2.262e-48 186.0 2DBB2@1|root,2Z858@2|Bacteria,4P25P@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - SRD1_k127_4928543_0 945713.IALB_1303 1.083e-83 289.0 COG2067@1|root,COG2067@2|Bacteria 2|Bacteria I long-chain fatty acid transporting porin activity - - - - - - - - - - - - UPF0164 SRD1_k127_4946617_1 263820.PTO0135 1.636e-28 133.0 COG0515@1|root,arCOG03682@2157|Archaea,2XWZP@28890|Euryarchaeota 28890|Euryarchaeota T serine threonine protein kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - NosD,Pkinase SRD1_k127_4946617_0 457398.HMPREF0326_01446 4.444e-54 206.0 COG1173@1|root,COG1173@2|Bacteria,1MU26@1224|Proteobacteria,42MFP@68525|delta/epsilon subdivisions,2WJ47@28221|Deltaproteobacteria,2M8HR@213115|Desulfovibrionales 28221|Deltaproteobacteria EP PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1,OppC_N SRD1_k127_4946617_2 1122135.KB893146_gene1770 5.209e-10 61.0 COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TRH6@28211|Alphaproteobacteria 28211|Alphaproteobacteria P COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components - - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 SRD1_k127_4950721_11 10181.XP_004872037.1 2.83e-05 51.0 KOG3529@1|root,KOG3529@2759|Eukaryota,39S2J@33154|Opisthokonta,3BFG4@33208|Metazoa,3CVUP@33213|Bilateria,48AB4@7711|Chordata,490UQ@7742|Vertebrata,3JEF0@40674|Mammalia,35HAU@314146|Euarchontoglires,4PZ8G@9989|Rodentia 33208|Metazoa S Coiled-coil domain-containing protein 120 CCDC120 GO:0000226,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005814,GO:0005815,GO:0005856,GO:0005929,GO:0006996,GO:0007010,GO:0007017,GO:0008104,GO:0008150,GO:0009987,GO:0015630,GO:0016043,GO:0032991,GO:0033036,GO:0034453,GO:0034454,GO:0042995,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044422,GO:0044424,GO:0044430,GO:0044441,GO:0044444,GO:0044446,GO:0044450,GO:0044463,GO:0044464,GO:0051179,GO:0071840,GO:0072393,GO:0120025,GO:0120038,GO:0120103 - - - - - - - - - - DUF3338 SRD1_k127_4950721_2 426355.Mrad2831_2033 3.295e-117 392.0 COG1914@1|root,COG1914@2|Bacteria,1MW6X@1224|Proteobacteria,2TRNM@28211|Alphaproteobacteria,1JRCJ@119045|Methylobacteriaceae 28211|Alphaproteobacteria P PFAM natural resistance-associated macrophage protein - - - - - - - - - - - - Nramp SRD1_k127_4950721_1 714943.Mucpa_2816 3.661e-119 397.0 COG3659@1|root,COG3659@2|Bacteria,4NHN1@976|Bacteroidetes,1IVAB@117747|Sphingobacteriia 976|Bacteroidetes M Belongs to the OprB family - - - ko:K16080 - - - - ko00000,ko02000 1.B.4.2.2 - - OprB SRD1_k127_4950721_6 517418.Ctha_1404 1.774e-60 216.0 COG1136@1|root,COG1136@2|Bacteria,1FENG@1090|Chlorobi 1090|Chlorobi V ATPases associated with a variety of cellular activities - - - - - - - - - - - - ABC_tran SRD1_k127_4950721_7 1519464.HY22_12335 4.952e-60 228.0 COG4591@1|root,COG4591@2|Bacteria,1FECJ@1090|Chlorobi 1090|Chlorobi M MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD SRD1_k127_4950721_0 933262.AXAM01000026_gene3074 1.004e-130 428.0 COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,42MAR@68525|delta/epsilon subdivisions,2WJEU@28221|Deltaproteobacteria,2MICK@213118|Desulfobacterales 28221|Deltaproteobacteria V FtsX-like permease family - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD SRD1_k127_4950721_3 1304284.L21TH_0519 1.812e-96 327.0 COG1136@1|root,COG1136@2|Bacteria,1TPBJ@1239|Firmicutes,248EZ@186801|Clostridia,36DXW@31979|Clostridiaceae 186801|Clostridia V ABC transporter macB - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran SRD1_k127_4950721_4 443143.GM18_2043 3.074e-81 289.0 COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,42NVA@68525|delta/epsilon subdivisions,2WMQK@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K02005 - - - - ko00000 - - - HlyD_D23 SRD1_k127_4950721_9 309807.SRU_0928 2.676e-17 90.0 COG1309@1|root,COG1309@2|Bacteria,4PES2@976|Bacteroidetes,1FJHY@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N SRD1_k127_4950721_5 945713.IALB_2853 1.471e-76 278.0 COG1538@1|root,COG1538@2|Bacteria 2|Bacteria MU efflux transmembrane transporter activity - - - - - - - - - - - - OEP SRD1_k127_4950721_8 880073.Calab_0506 5.52e-35 150.0 COG0845@1|root,COG0845@2|Bacteria,2NQN5@2323|unclassified Bacteria 2|Bacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - HlyD_3,HlyD_D23 SRD1_k127_4950721_10 1009370.ALO_04968 4.556e-13 71.0 COG0841@1|root,COG0841@2|Bacteria,1TQ03@1239|Firmicutes,4H20U@909932|Negativicutes 909932|Negativicutes V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran SRD1_k127_4958261_2 1552758.NC00_18900 2.748e-38 150.0 COG0500@1|root,COG2226@2|Bacteria,1R8N9@1224|Proteobacteria,1SYVC@1236|Gammaproteobacteria,1X2Z5@135614|Xanthomonadales 135614|Xanthomonadales Q Methyltransferase - - - - - - - - - - - - Methyltransf_25 SRD1_k127_4958261_0 309807.SRU_2836 1.926e-66 248.0 COG1132@1|root,COG1132@2|Bacteria,4PKCT@976|Bacteroidetes,1FJV9@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes V ABC transporter - - - ko:K06147,ko:K11085 ko02010,map02010 - - - ko00000,ko00001,ko01000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran SRD1_k127_4958261_1 1237149.C900_03820 2.026e-40 161.0 COG0859@1|root,COG0859@2|Bacteria,4P2TG@976|Bacteroidetes 976|Bacteroidetes M Glycosyltransferase family 9 (heptosyltransferase) - - - - - - - - - - - - Glyco_transf_9 SRD1_k127_4968810_2 1313421.JHBV01000030_gene2312 4.85e-72 251.0 COG0600@1|root,COG0600@2|Bacteria,4NPPC@976|Bacteroidetes,1IXWZ@117747|Sphingobacteriia 976|Bacteroidetes P Binding-protein-dependent transport system inner membrane component - - - ko:K02050,ko:K15577 ko00910,ko02010,map00910,map02010 M00188,M00438 - - ko00000,ko00001,ko00002,ko02000 3.A.1.16,3.A.1.16.1,3.A.1.16.2,3.A.1.17 - - BPD_transp_1 SRD1_k127_4968810_1 1296415.JACC01000008_gene2344 2.656e-95 320.0 COG1116@1|root,COG1116@2|Bacteria,4PKJ3@976|Bacteroidetes,1HZNX@117743|Flavobacteriia,2YKDU@290174|Aquimarina 976|Bacteroidetes P ATPases associated with a variety of cellular activities - - - ko:K02049 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - ABC_tran SRD1_k127_4968810_0 452637.Oter_2894 4.173e-200 646.0 2C0ZI@1|root,2ZAKK@2|Bacteria,46Z56@74201|Verrucomicrobia,3K95T@414999|Opitutae 414999|Opitutae S Heparinase II/III-like protein - - - - - - - - - - - - Hepar_II_III SRD1_k127_4968810_3 1461694.ATO9_02910 8.791e-05 55.0 COG2159@1|root,COG2159@2|Bacteria,1MUUR@1224|Proteobacteria,2TSQB@28211|Alphaproteobacteria,2PDNC@252301|Oceanicola 28211|Alphaproteobacteria S Amidohydrolase MA20_05990 - - ko:K07045 - - - - ko00000 - - - Amidohydro_2 SRD1_k127_4973798_0 945713.IALB_2125 2.592e-60 230.0 2EUGM@1|root,33MYV@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - SRD1_k127_4973798_1 517418.Ctha_1614 9.569e-23 107.0 COG2172@1|root,COG2172@2|Bacteria,1FE8I@1090|Chlorobi 1090|Chlorobi T Histidine kinase-like ATPase domain - - 2.7.11.1 ko:K04757 - - - - ko00000,ko01000,ko01001,ko03021 - - - HATPase_c_2 SRD1_k127_4980163_2 880071.Fleli_1487 3.949e-63 224.0 COG2911@1|root,COG2911@2|Bacteria,4NF7F@976|Bacteroidetes,47JE0@768503|Cytophagia 976|Bacteroidetes M PFAM Family of - - - - - - - - - - - - TamB SRD1_k127_4980163_0 468059.AUHA01000006_gene2854 6.147e-202 653.0 COG4775@1|root,COG4775@2|Bacteria,4NE80@976|Bacteroidetes,1IPP9@117747|Sphingobacteriia 976|Bacteroidetes M Outer membrane protein protective antigen OMA87 - - - - - - - - - - - - Bac_surface_Ag SRD1_k127_4980163_3 1122179.KB890417_gene3276 1.263e-41 165.0 COG1073@1|root,COG1073@2|Bacteria 2|Bacteria S thiolester hydrolase activity - - - - - - - - - - - - Hydrolase_4 SRD1_k127_4980163_1 518766.Rmar_0624 2.005e-132 453.0 COG2091@1|root,COG2091@2|Bacteria,4NFQ6@976|Bacteroidetes 976|Bacteroidetes H lysine biosynthetic process via aminoadipic acid - - - - - - - - - - - - CBM9_1 SRD1_k127_498449_1 247490.KSU1_C0699 6.353e-79 285.0 COG0845@1|root,COG0845@2|Bacteria,2IZ3N@203682|Planctomycetes 203682|Planctomycetes M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K02005 - - - - ko00000 - - - HlyD_D23 SRD1_k127_498449_0 234267.Acid_3645 3.534e-112 371.0 COG0329@1|root,COG0329@2|Bacteria,3Y80Z@57723|Acidobacteria 57723|Acidobacteria EM Dihydrodipicolinate synthetase family - - 4.3.3.7 ko:K01714 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 - - - DHDPS SRD1_k127_498449_2 309801.trd_A0087 5.855e-08 57.0 COG1028@1|root,COG1028@2|Bacteria,2G8II@200795|Chloroflexi,27XKN@189775|Thermomicrobia 189775|Thermomicrobia IQ Dehydrogenase reductase sdr - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 SRD1_k127_4990275_1 518766.Rmar_2301 1.746e-89 317.0 COG0457@1|root,COG0457@2|Bacteria 518766.Rmar_2301|- S peptidyl-tyrosine sulfation - - - - - - - - - - - - - SRD1_k127_4990275_2 237368.SCABRO_02413 2.201e-74 263.0 29MQ2@1|root,308MT@2|Bacteria,2J179@203682|Planctomycetes 203682|Planctomycetes - - - - - - - - - - - - - - - SRD1_k127_4990275_3 746697.Aeqsu_1810 5.527e-71 249.0 COG0500@1|root,COG2226@2|Bacteria,4NG68@976|Bacteroidetes,1I0VV@117743|Flavobacteriia 976|Bacteroidetes Q Methyltransferase - - - - - - - - - - - - Methyltransf_11 SRD1_k127_4990275_0 697281.Mahau_1296 2.499e-99 335.0 COG0407@1|root,COG0407@2|Bacteria,1V4YU@1239|Firmicutes,24FCZ@186801|Clostridia,42HY1@68295|Thermoanaerobacterales 186801|Clostridia H PFAM Uroporphyrinogen decarboxylase (URO-D) - - 4.1.1.37 ko:K01599 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000 - - - URO-D SRD1_k127_4990275_5 517417.Cpar_1354 4.746e-47 186.0 COG2340@1|root,COG2340@2|Bacteria 2|Bacteria S peptidase inhibitor activity - - - - - - - - - - - - CAP SRD1_k127_4990275_4 290512.Paes_2197 2.331e-62 218.0 COG1592@1|root,COG1592@2|Bacteria,1FE9N@1090|Chlorobi 1090|Chlorobi C PFAM Rubrerythrin - - - - - - - - - - - - Rubrerythrin SRD1_k127_4990275_6 1410613.JNKF01000012_gene1411 1.509e-20 102.0 COG4372@1|root,COG4372@2|Bacteria,4NMT7@976|Bacteroidetes,2FNI1@200643|Bacteroidia 976|Bacteroidetes S Transposase - - - - - - - - - - - - - SRD1_k127_4990275_7 1089547.KB913013_gene3602 3.166e-09 59.0 COG0702@1|root,COG0702@2|Bacteria,4NGMR@976|Bacteroidetes,47NYS@768503|Cytophagia 976|Bacteroidetes GM epimerase - - - - - - - - - - - - Epimerase SRD1_k127_4997882_1 880073.Calab_0218 1.627e-157 505.0 COG0183@1|root,COG0183@2|Bacteria,2NNU9@2323|unclassified Bacteria 2|Bacteria I Belongs to the thiolase family atoB - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - iJN746.PP_2215 Thiolase_C,Thiolase_N SRD1_k127_4997882_2 1379270.AUXF01000005_gene596 8.583e-120 391.0 COG1250@1|root,COG1250@2|Bacteria,1ZSRN@142182|Gemmatimonadetes 142182|Gemmatimonadetes I 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain - - 1.1.1.157 ko:K00074 ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120 - R01976,R05576,R06941 RC00029,RC00117 ko00000,ko00001,ko01000 - - - 3HCDH,3HCDH_N SRD1_k127_4997882_0 945713.IALB_2277 1.6e-159 512.0 COG1960@1|root,COG1960@2|Bacteria 2|Bacteria I acyl-CoA dehydrogenase activity bcd - 1.3.8.1 ko:K00248 ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212 - R01175,R01178,R02661,R03172,R04751 RC00052,RC00068,RC00076,RC00120,RC00148 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N SRD1_k127_4997882_3 1235803.C825_02858 8.047e-10 68.0 COG3637@1|root,COG3637@2|Bacteria,4NR9K@976|Bacteroidetes,2FU82@200643|Bacteroidia,231DZ@171551|Porphyromonadaceae 976|Bacteroidetes M Outer membrane protein beta-barrel domain - - - - - - - - - - - - OMP_b-brl,OMP_b-brl_2 SRD1_k127_4997882_4 104623.Ser39006_02109 4.838e-07 58.0 COG1566@1|root,COG1566@2|Bacteria,1MU7I@1224|Proteobacteria,1RMAD@1236|Gammaproteobacteria,404YH@613|Serratia 1236|Gammaproteobacteria V Biotin-lipoyl like emrA - - ko:K03543 - M00701 - - ko00000,ko00002,ko02000 8.A.1.1 - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 SRD1_k127_5015552_2 1191523.MROS_0139 7.909e-63 216.0 COG0017@1|root,COG0017@2|Bacteria 2|Bacteria J Asparaginyl-tRNA synthetase asnS GO:0003674,GO:0003824,GO:0004812,GO:0004816,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006421,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.22 ko:K01893 ko00970,map00970 M00359,M00360 R03648 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon SRD1_k127_5015552_1 945713.IALB_1997 4.587e-89 303.0 COG4152@1|root,COG4152@2|Bacteria 2|Bacteria S ATPase activity natA - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran,DUF4162 SRD1_k127_5015552_0 945713.IALB_1998 3.503e-90 313.0 COG1668@1|root,COG1668@2|Bacteria 2|Bacteria CP transmembrane transport - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 SRD1_k127_5016469_7 717605.Theco_1234 7.978e-31 134.0 COG0451@1|root,COG0451@2|Bacteria,1TPHV@1239|Firmicutes,4HCJR@91061|Bacilli,26SNR@186822|Paenibacillaceae 91061|Bacilli GM epimerase - - - - - - - - - - - - Epimerase SRD1_k127_5016469_5 997346.HMPREF9374_3654 1.745e-47 184.0 COG0329@1|root,COG0329@2|Bacteria,1UNIU@1239|Firmicutes,4HAWE@91061|Bacilli,27CTM@186824|Thermoactinomycetaceae 91061|Bacilli EM Dihydrodipicolinate synthetase family - - - - - - - - - - - - DHDPS SRD1_k127_5016469_9 1304878.AUGD01000005_gene3460 1.419e-11 72.0 COG3663@1|root,COG3663@2|Bacteria,1RAVZ@1224|Proteobacteria,2UDH2@28211|Alphaproteobacteria,3JVC8@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L Uracil DNA glycosylase superfamily mug - 3.2.2.28 ko:K03649 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG SRD1_k127_5016469_3 1304880.JAGB01000001_gene487 2.583e-87 289.0 COG4030@1|root,COG4030@2|Bacteria,1TRZY@1239|Firmicutes,249GP@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - DUF2961 SRD1_k127_5016469_2 357808.RoseRS_2835 2.265e-102 340.0 COG4030@1|root,COG4030@2|Bacteria,2G67Q@200795|Chloroflexi 200795|Chloroflexi S Protein of unknown function (DUF2961) - - - - - - - - - - - - DUF2961 SRD1_k127_5016469_1 1128421.JAGA01000001_gene2190 1.463e-135 442.0 COG0346@1|root,COG0346@2|Bacteria,2NR6J@2323|unclassified Bacteria 2|Bacteria E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - ko:K15975 - - - - ko00000 - - - Glyoxalase SRD1_k127_5016469_4 449447.MAE_10360 8.269e-83 298.0 COG0591@1|root,COG0591@2|Bacteria,1G1JV@1117|Cyanobacteria 1117|Cyanobacteria E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - - - - - - - - - - SSF SRD1_k127_5016469_0 1121920.AUAU01000020_gene2550 4.996e-222 698.0 COG0433@1|root,COG0433@2|Bacteria,3Y69X@57723|Acidobacteria 57723|Acidobacteria S Bacterial protein of unknown function (DUF853) - - - - - - - - - - - - DUF853 SRD1_k127_5016469_8 880073.Calab_3510 1.92e-22 105.0 COG1404@1|root,COG1404@2|Bacteria 2|Bacteria O Belongs to the peptidase S8 family - - 3.4.21.96 ko:K01361,ko:K20276 ko02024,map02024 - - - ko00000,ko00001,ko01000,ko01002,ko03110 - - - B_lectin,DUF11,Gram_pos_anchor,Peptidase_S8,SLH,SdrD_B,fn3_5 SRD1_k127_5022960_1 886293.Sinac_7544 2.128e-90 313.0 COG0784@1|root,COG2198@1|root,COG2202@1|root,COG2203@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG5002@2|Bacteria,2J4YH@203682|Planctomycetes 203682|Planctomycetes T His Kinase A (phosphoacceptor - - - - - - - - - - - - HATPase_c,HisKA,Hpt,PAS_4,Response_reg SRD1_k127_5022960_0 1173024.KI912151_gene2355 3.123e-107 365.0 COG0784@1|root,COG3437@1|root,COG5000@1|root,COG0784@2|Bacteria,COG3437@2|Bacteria,COG5000@2|Bacteria,1GHJE@1117|Cyanobacteria,1JI33@1189|Stigonemataceae 1117|Cyanobacteria T Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - - - - - - - - - - CBS,HATPase_c,HisKA,PAS,PAS_9,Response_reg SRD1_k127_5025784_1 1239962.C943_01005 4.346e-168 549.0 COG1262@1|root,COG1262@2|Bacteria,4NJRT@976|Bacteroidetes,47TU9@768503|Cytophagia 976|Bacteroidetes S Sulfatase-modifying factor enzyme 1 - - - - - - - - - - - - FGE-sulfatase SRD1_k127_5025784_0 880073.Calab_0034 1.405e-259 816.0 COG3408@1|root,COG3408@2|Bacteria,2NPVQ@2323|unclassified Bacteria 2|Bacteria G Trehalase - - - ko:K03931 - - - - ko00000 - GH63 - Glyco_hydro_63,Trehalase SRD1_k127_503258_0 945713.IALB_1644 6.136e-251 793.0 COG1629@1|root,COG4771@2|Bacteria 2|Bacteria P TonB-dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_dep_Rec SRD1_k127_5047572_1 1191523.MROS_1178 6.369e-42 158.0 COG0313@1|root,COG0313@2|Bacteria 2|Bacteria H rRNA processing rsmI_1 - 2.1.1.198 ko:K07056 - - - - ko00000,ko01000,ko03009 - - - TP_methylase SRD1_k127_5047572_0 880073.Calab_2536 6.584e-97 327.0 COG1045@1|root,COG1045@2|Bacteria,2NPQG@2323|unclassified Bacteria 2|Bacteria E Bacterial transferase hexapeptide (six repeats) cysE - 2.3.1.30 ko:K00640 ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111 M00021 R00586 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,SATase_N SRD1_k127_5047572_2 290397.Adeh_1548 1.935e-38 156.0 COG3115@1|root,COG3115@2|Bacteria,1QW35@1224|Proteobacteria,42UFZ@68525|delta/epsilon subdivisions,2WR5D@28221|Deltaproteobacteria 28221|Deltaproteobacteria D cell septum assembly - - - - - - - - - - - - - SRD1_k127_5047572_3 1150621.SMUL_1954 1.422e-09 62.0 COG0730@1|root,COG0730@2|Bacteria,1MXNM@1224|Proteobacteria,42KZF@68525|delta/epsilon subdivisions,2YMND@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S membrane transporter protein - - - ko:K07090 - - - - ko00000 - - - TauE SRD1_k127_5050100_0 861299.J421_5610 5.826e-64 227.0 COG1129@1|root,COG1129@2|Bacteria,1ZVAU@142182|Gemmatimonadetes 2|Bacteria G ABC transporter - - 3.6.3.17 ko:K10441 ko02010,map02010 M00212 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 - - ABC_tran SRD1_k127_5055086_0 1267535.KB906767_gene4770 0.0 1157.0 COG0841@1|root,COG0841@2|Bacteria,3Y2RX@57723|Acidobacteria,2JIU0@204432|Acidobacteriia 204432|Acidobacteriia V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran SRD1_k127_5055086_1 234267.Acid_7567 1.29e-39 153.0 COG1538@1|root,COG1538@2|Bacteria,3Y3JU@57723|Acidobacteria 57723|Acidobacteria MU Outer membrane efflux protein - - - ko:K12340 ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133 M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko02044 1.B.17,2.A.6.2 - - OEP SRD1_k127_5067818_2 411902.CLOBOL_05283 1.148e-05 48.0 COG0163@1|root,COG0163@2|Bacteria,1V3JV@1239|Firmicutes,24HE5@186801|Clostridia,220IG@1506553|Lachnoclostridium 186801|Clostridia H Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN ubiX - 2.5.1.129 ko:K03186 ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220 M00117 R01238,R02952,R03367,R04985,R04986,R11225 RC00391,RC00814,RC03392 ko00000,ko00001,ko00002,ko01000 - - - Flavoprotein SRD1_k127_5067818_0 237368.SCABRO_01870 1.056e-233 739.0 COG0043@1|root,COG0043@2|Bacteria,2IYCA@203682|Planctomycetes 203682|Planctomycetes H COG0043 3-polyprenyl-4-hydroxybenzoate decarboxylase and - - 4.1.1.98 ko:K03182 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04985,R04986 RC00391 ko00000,ko00001,ko00002,ko01000 - - - UbiD SRD1_k127_5067818_1 1158318.ATXC01000001_gene1035 3.251e-42 160.0 COG1060@1|root,COG1060@2|Bacteria,2G3M7@200783|Aquificae 200783|Aquificae H Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate mqnE - 2.5.1.120 ko:K18285 ko00130,ko01110,map00130,map01110 - R10667 RC00021,RC03234 ko00000,ko00001,ko01000 - - - Fer4_14,Radical_SAM SRD1_k127_5072702_0 671143.DAMO_2498 9.422e-145 466.0 COG1180@1|root,COG1180@2|Bacteria,2NP82@2323|unclassified Bacteria 2|Bacteria O Radical SAM superfamily pflA - 1.97.1.4 ko:K04069 - - R04710 - ko00000,ko01000 - - - Fer4_12,Radical_SAM SRD1_k127_5072702_2 1124780.ANNU01000006_gene2818 2.422e-59 215.0 COG1215@1|root,COG1215@2|Bacteria,4NFUA@976|Bacteroidetes,47RJC@768503|Cytophagia 976|Bacteroidetes M N-terminal domain of galactosyltransferase - - - - - - - - - - - - Glyco_transf_7C,Glycos_transf_2 SRD1_k127_5072702_3 411471.SUBVAR_06123 8.733e-29 119.0 COG0640@1|root,COG0640@2|Bacteria,1VA6G@1239|Firmicutes,24JCN@186801|Clostridia,3WK18@541000|Ruminococcaceae 186801|Clostridia K regulatory protein, arsR ziaR - - ko:K21903 - - - - ko00000,ko03000 - - - HTH_5 SRD1_k127_5072702_1 1121428.DESHY_10209___1 1.955e-122 413.0 COG2217@1|root,COG2217@2|Bacteria,1TQ07@1239|Firmicutes,248EH@186801|Clostridia,260Y1@186807|Peptococcaceae 186801|Clostridia P ATPase, P-type (transporting), HAD superfamily, subfamily IC cadA - 3.6.3.3,3.6.3.5 ko:K01534 - - - - ko00000,ko01000 3.A.3.6 - - E1-E2_ATPase,HMA,Hydrolase SRD1_k127_508518_4 204669.Acid345_2910 2.265e-41 155.0 COG2271@1|root,COG2271@2|Bacteria,3Y2VG@57723|Acidobacteria,2JIWZ@204432|Acidobacteriia 204432|Acidobacteriia G Major Facilitator Superfamily - - - ko:K08191 - - - - ko00000,ko02000 2.A.1.14.2 - - MFS_1 SRD1_k127_508518_2 483216.BACEGG_01442 4.315e-87 303.0 COG1082@1|root,COG1082@2|Bacteria 2|Bacteria G myo-inosose-2 dehydratase activity - - - - - - - - - - - - AP_endonuc_2,AP_endonuc_2_N SRD1_k127_508518_5 1123487.KB892834_gene2740 1.032e-18 91.0 COG0346@1|root,COG0346@2|Bacteria 2|Bacteria E lactoylglutathione lyase activity - - 4.4.1.5 ko:K01759,ko:K08234 ko00620,map00620 - R02530 RC00004,RC00740 ko00000,ko00001,ko01000 - - - Glyoxalase,Glyoxalase_4 SRD1_k127_508518_3 1223410.KN050846_gene205 8.723e-81 279.0 2DCFR@1|root,2ZDYQ@2|Bacteria,4NPNX@976|Bacteroidetes,1I27F@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - DUF4440 SRD1_k127_508518_1 1120949.KB903303_gene6761 6.914e-88 299.0 COG0500@1|root,COG2226@2|Bacteria,2GNTH@201174|Actinobacteria,4D8MM@85008|Micromonosporales 201174|Actinobacteria Q Methyltransferase domain - - - - - - - - - - - - Methyltransf_11,Methyltransf_25 SRD1_k127_508518_0 1047013.AQSP01000125_gene2621 7.961e-104 356.0 COG0591@1|root,COG0591@2|Bacteria 2|Bacteria E symporter activity - - - ko:K03307 - - - - ko00000 2.A.21 - - SSF SRD1_k127_508518_6 595460.RRSWK_06077 2.386e-09 57.0 COG5426@1|root,COG5426@2|Bacteria,2J31F@203682|Planctomycetes 203682|Planctomycetes S Putative glutamine amidotransferase - - - - - - - - - - - - GATase1_like SRD1_k127_5088426_4 586416.GZ22_08505 5.932e-16 79.0 COG0492@1|root,COG0492@2|Bacteria,1TQGS@1239|Firmicutes,4HBIS@91061|Bacilli 91061|Bacilli O Thioredoxin reductase ypdA - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_3 SRD1_k127_5088426_0 1191523.MROS_2362 4.597e-241 756.0 COG0055@1|root,COG0055@2|Bacteria 2|Bacteria C proton-transporting ATP synthase activity, rotational mechanism atpD GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - e_coli_core.b3732,iAF1260.b3732,iAPECO1_1312.APECO1_2729,iB21_1397.B21_03560,iBWG_1329.BWG_3423,iE2348C_1286.E2348C_4042,iEC042_1314.EC042_4119,iEC55989_1330.EC55989_4207,iECABU_c1320.ECABU_c42160,iECBD_1354.ECBD_4300,iECB_1328.ECB_03616,iECDH10B_1368.ECDH10B_3919,iECDH1ME8569_1439.ECDH1ME8569_3620,iECD_1391.ECD_03616,iECED1_1282.ECED1_4422,iECH74115_1262.ECH74115_5168,iECIAI1_1343.ECIAI1_3916,iECIAI39_1322.ECIAI39_4336,iECNA114_1301.ECNA114_3881,iECO103_1326.ECO103_4426,iECO111_1330.ECO111_4566,iECO26_1355.ECO26_4846,iECOK1_1307.ECOK1_4181,iECP_1309.ECP_3931,iECS88_1305.ECS88_4154,iECSE_1348.ECSE_4022,iECSF_1327.ECSF_3580,iECSP_1301.ECSP_4782,iECUMN_1333.ECUMN_4262,iECW_1372.ECW_m4035,iECs_1301.ECs4674,iEKO11_1354.EKO11_4613,iETEC_1333.ETEC_4023,iEcDH1_1363.EcDH1_4235,iEcE24377_1341.EcE24377A_4247,iEcSMS35_1347.EcSMS35_4100,iEcolC_1368.EcolC_4262,iG2583_1286.G2583_4528,iJO1366.b3732,iJR904.b3732,iLF82_1304.LF82_0194,iNRG857_1313.NRG857_18585,iPC815.YPO4121,iSFV_1184.SFV_3758,iSF_1195.SF3812,iSFxv_1172.SFxv_4154,iSSON_1240.SSON_3887,iS_1188.S3956,iSbBS512_1146.SbBS512_E4189,iUMN146_1321.UM146_18850,iUMNK88_1353.UMNK88_4544,iUTI89_1310.UTI89_C4285,iWFL_1372.ECW_m4035,iY75_1357.Y75_RS18410,iZ_1308.Z5230,ic_1306.c4658 ATP-synt_ab,ATP-synt_ab_N SRD1_k127_5088426_5 1236976.JCM16418_4385 2.187e-15 81.0 COG0355@1|root,COG0355@2|Bacteria,1VA89@1239|Firmicutes,4HKHS@91061|Bacilli,26Y3T@186822|Paenibacillaceae 91061|Bacilli C Produces ATP from ADP in the presence of a proton gradient across the membrane atpC GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - ko:K02114 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_DE,ATP-synt_DE_N SRD1_k127_5088426_1 1191523.MROS_0017 1.449e-118 392.0 COG0836@1|root,COG0836@2|Bacteria 2|Bacteria M mannose-1-phosphate guanylyltransferase activity manC - 2.7.7.13,5.3.1.8,5.4.2.8 ko:K00971,ko:K01840,ko:K16011 ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025 M00114,M00361,M00362 R00885,R01818,R01819 RC00002,RC00376,RC00408 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS00940 MannoseP_isomer,NTP_transferase SRD1_k127_5088426_2 882.DVU_0397 2.383e-33 133.0 COG0797@1|root,COG3087@1|root,COG0797@2|Bacteria,COG3087@2|Bacteria,1MZ8S@1224|Proteobacteria,42PQF@68525|delta/epsilon subdivisions,2WMCA@28221|Deltaproteobacteria,2MBVF@213115|Desulfovibrionales 28221|Deltaproteobacteria M Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides rlpA - - ko:K03642 - - - - ko00000 - - - DPBB_1,SPOR SRD1_k127_5088426_3 880073.Calab_1788 3.597e-30 131.0 COG4623@1|root,COG4623@2|Bacteria 2|Bacteria M carbon-oxygen lyase activity, acting on polysaccharides mltF - - ko:K18691 - - - - ko00000,ko01000,ko01011 - - - SBP_bac_3,SLT SRD1_k127_5092692_2 665956.HMPREF1032_00835 6.26e-68 250.0 COG1940@1|root,COG1940@2|Bacteria,1TRGJ@1239|Firmicutes,248TJ@186801|Clostridia,3WNES@541000|Ruminococcaceae 186801|Clostridia GK ROK family - - 2.7.1.2 ko:K00845 ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R01600,R01786 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - ROK SRD1_k127_5092692_3 357808.RoseRS_2960 3.249e-48 179.0 COG0251@1|root,COG0251@2|Bacteria,2G6XT@200795|Chloroflexi,375RE@32061|Chloroflexia 32061|Chloroflexia J PFAM Endoribonuclease L-PSP - - 3.5.99.10 ko:K09022 - - R11098,R11099 RC03275,RC03354 ko00000,ko01000 - - - Ribonuc_L-PSP SRD1_k127_5092692_0 1288963.ADIS_1304 2.476e-188 597.0 COG0673@1|root,COG0673@2|Bacteria,4NKJ1@976|Bacteroidetes,47JK9@768503|Cytophagia 976|Bacteroidetes S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C SRD1_k127_5092692_1 234267.Acid_7125 1.512e-74 254.0 COG0662@1|root,COG0662@2|Bacteria,3Y6AM@57723|Acidobacteria 57723|Acidobacteria G Mannose-6-phosphate isomerase - - - - - - - - - - - - Cupin_2 SRD1_k127_5092692_4 880073.Calab_2959 1.588e-12 73.0 COG1629@1|root,COG4771@2|Bacteria,2NP6Z@2323|unclassified Bacteria 2|Bacteria P COGs COG1629 Outer membrane receptor protein mostly Fe transport - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_dep_Rec SRD1_k127_5099594_4 880073.Calab_2081 1.567e-20 101.0 COG3291@1|root,COG5276@1|root,COG3291@2|Bacteria,COG5276@2|Bacteria,2NQ2P@2323|unclassified Bacteria 2|Bacteria P LVIVD repeat - - 3.2.1.4 ko:K01179 ko00500,ko01100,map00500,map01100 - R06200,R11307,R11308 - ko00000,ko00001,ko01000 - GH5,GH9 - LVIVD SRD1_k127_5099594_1 251229.Chro_4970 2.563e-62 220.0 COG0259@1|root,COG0259@2|Bacteria,1G0HC@1117|Cyanobacteria,3VJ47@52604|Pleurocapsales 1117|Cyanobacteria H Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) pdxH - 1.4.3.5 ko:K00275 ko00750,ko01100,ko01120,map00750,map01100,map01120 M00124 R00277,R00278,R01710,R01711 RC00048,RC00116 ko00000,ko00001,ko00002,ko01000 - - iJN678.pdxH PNP_phzG_C,Putative_PNPOx SRD1_k127_5099594_5 1184267.A11Q_1746 1.105e-13 78.0 2E1HF@1|root,32WVJ@2|Bacteria,1NHTX@1224|Proteobacteria,42X6V@68525|delta/epsilon subdivisions,2MUCB@213481|Bdellovibrionales,2WSSD@28221|Deltaproteobacteria 213481|Bdellovibrionales - - - - - - - - - - - - - - - SRD1_k127_5099594_2 1449126.JQKL01000073_gene3042 1.455e-34 138.0 COG0295@1|root,COG0295@2|Bacteria,1V6IP@1239|Firmicutes,24JEM@186801|Clostridia,268ZJ@186813|unclassified Clostridiales 186801|Clostridia F This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis cdd - 3.5.4.5 ko:K01489 ko00240,ko00983,ko01100,map00240,map00983,map01100 - R01878,R02485,R08221 RC00074,RC00514 ko00000,ko00001,ko01000 - - - dCMP_cyt_deam_1 SRD1_k127_5099594_0 714943.Mucpa_1212 4.176e-111 373.0 COG0531@1|root,COG0531@2|Bacteria 2|Bacteria E amino acid - - - - - - - - - - - - AA_permease_2 SRD1_k127_5099594_3 1121920.AUAU01000014_gene2790 4.307e-22 98.0 2EK70@1|root,33DXD@2|Bacteria,3Y5QD@57723|Acidobacteria 57723|Acidobacteria - - - - - - - - - - - - - - - SRD1_k127_5103027_1 1121468.AUBR01000030_gene1238 2.369e-101 351.0 COG0182@1|root,COG0182@2|Bacteria,1TPDK@1239|Firmicutes,249C5@186801|Clostridia,42F9M@68295|Thermoanaerobacterales 186801|Clostridia J Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) mtnA - 5.3.1.23 ko:K08963 ko00270,ko01100,map00270,map01100 M00034 R04420 RC01151 ko00000,ko00001,ko00002,ko01000 - - - IF-2B SRD1_k127_5103027_0 945713.IALB_1760 2.035e-107 351.0 COG0524@1|root,COG0524@2|Bacteria 2|Bacteria G Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway adoK GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0004001,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005975,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019200,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032549,GO:0032550,GO:0032552,GO:0032553,GO:0032554,GO:0032555,GO:0032559,GO:0032560,GO:0032561,GO:0032567,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046390,GO:0046483,GO:0046835,GO:0046872,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.1.15,2.7.1.20 ko:K00852,ko:K00856 ko00030,ko00230,ko01100,map00030,map00230,map01100 - R00185,R01051,R02750 RC00002,RC00017 ko00000,ko00001,ko01000 - - iAF987.Gmet_2683 PfkB SRD1_k127_5126806_1 880073.Calab_1563 3.11e-67 257.0 COG1629@1|root,COG1629@2|Bacteria,2NS4U@2323|unclassified Bacteria 2|Bacteria P PFAM TonB-dependent Receptor Plug Domain - - - - - - - - - - - - CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_dep_Rec SRD1_k127_5126806_0 1121904.ARBP01000010_gene2343 1.83e-78 274.0 COG1609@1|root,COG1609@2|Bacteria,4NESN@976|Bacteroidetes,47NJN@768503|Cytophagia 976|Bacteroidetes K helix_turn _helix lactose operon repressor - - - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_1,Peripla_BP_3,Peripla_BP_4 SRD1_k127_5126806_2 1519464.HY22_13055 1.705e-23 117.0 COG0265@1|root,COG0366@1|root,COG0265@2|Bacteria,COG0366@2|Bacteria 2|Bacteria G hydrolase activity, hydrolyzing O-glycosyl compounds - - 3.4.21.50 ko:K01337 - - - - ko00000,ko01000,ko01002 - - - Alpha-amylase SRD1_k127_5126806_3 234267.Acid_1455 5.059e-18 90.0 COG0265@1|root,COG2234@1|root,COG0265@2|Bacteria,COG2234@2|Bacteria,3Y46R@57723|Acidobacteria 57723|Acidobacteria O PA domain - - - - - - - - - - - - PA,PDZ_2,Peptidase_M28 SRD1_k127_5136761_1 479434.Sthe_3260 6.672e-72 253.0 COG1194@1|root,COG1194@2|Bacteria,2G62P@200795|Chloroflexi,27XJQ@189775|Thermomicrobia 189775|Thermomicrobia L FES - - - ko:K03575 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - HhH-GPD SRD1_k127_5136761_3 1278306.KB906926_gene1685 4.385e-37 147.0 COG1059@1|root,COG1059@2|Bacteria,37905@32066|Fusobacteria 32066|Fusobacteria L Psort location Cytoplasmic, score 8.96 ogg - 4.2.99.18 ko:K03653 - - - - ko00000,ko01000 - - - - SRD1_k127_5136761_2 1121346.KB899818_gene2556 8.982e-61 213.0 COG1666@1|root,COG1666@2|Bacteria,1V3UR@1239|Firmicutes,4HHVD@91061|Bacilli,26WQF@186822|Paenibacillaceae 91061|Bacilli S Belongs to the UPF0234 family yitK - - ko:K09767 - - - - ko00000 - - - DUF520 SRD1_k127_5136761_0 1191523.MROS_0673 1.516e-106 364.0 COG0860@1|root,COG0860@2|Bacteria 2|Bacteria M N-Acetylmuramoyl-L-alanine amidase amiA - 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - Amidase_3 SRD1_k127_51407_0 945713.IALB_2321 3.518e-146 486.0 COG0308@1|root,COG0308@2|Bacteria 2|Bacteria E peptide catabolic process pepN1 - - - - - - - - - - - Peptidase_M1 SRD1_k127_51407_1 1111479.AXAR01000008_gene2386 1.568e-11 64.0 COG1066@1|root,COG1066@2|Bacteria,1TQ7Y@1239|Firmicutes,4H9YC@91061|Bacilli,2786D@186823|Alicyclobacillaceae 91061|Bacilli O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function radA - - ko:K04485 - - - - ko00000,ko03400 - - - AAA_25,ATPase,ChlI SRD1_k127_5157412_1 204669.Acid345_0767 8.941e-31 130.0 COG0509@1|root,COG0509@2|Bacteria,3Y7RS@57723|Acidobacteria 57723|Acidobacteria E Glycine cleavage H-protein - - - - - - - - - - - - GCV_H SRD1_k127_5157412_2 234267.Acid_4203 3.639e-17 90.0 COG0509@1|root,COG0509@2|Bacteria,3Y7RS@57723|Acidobacteria 57723|Acidobacteria E Glycine cleavage H-protein - - - - - - - - - - - - GCV_H SRD1_k127_5157412_0 1121920.AUAU01000012_gene2649 7.943e-74 255.0 COG0437@1|root,COG0437@2|Bacteria,3Y5RE@57723|Acidobacteria 57723|Acidobacteria C 4Fe-4S dicluster domain - - - - - - - - - - - - Fer4_11 SRD1_k127_5185541_0 234267.Acid_5307 0.0 1024.0 COG0508@1|root,COG0567@1|root,COG0508@2|Bacteria,COG0567@2|Bacteria,3Y3EF@57723|Acidobacteria 57723|Acidobacteria C 2-oxoglutarate dehydrogenase, E1 - - 1.2.4.2 ko:K00164 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,E1_dh,OxoGdeHyase_C,Transket_pyr SRD1_k127_5185541_3 889378.Spiaf_0750 7.815e-66 251.0 COG4206@1|root,COG4206@2|Bacteria,2J7XW@203691|Spirochaetes 203691|Spirochaetes H TonB-dependent receptor - - - ko:K16092 - - - - ko00000,ko02000 1.B.14.3 - - Plug,TonB_dep_Rec SRD1_k127_5185541_6 945713.IALB_2301 1.654e-09 69.0 COG3391@1|root,COG3391@2|Bacteria 2|Bacteria CO amine dehydrogenase activity - - - - - - - - - - - - - SRD1_k127_5185541_4 378806.STAUR_8302 3.887e-25 110.0 COG3279@1|root,COG3279@2|Bacteria,1MUE8@1224|Proteobacteria,42RCM@68525|delta/epsilon subdivisions,2WN89@28221|Deltaproteobacteria,2YVX5@29|Myxococcales 28221|Deltaproteobacteria K LytTr DNA-binding domain - - - ko:K02477 - - - - ko00000,ko02022 - - - LytTR,Response_reg SRD1_k127_5185541_5 1185876.BN8_02959 3.476e-24 113.0 COG4319@1|root,COG4319@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - Abhydrolase_1,DUF4440,SnoaL_2,SnoaL_3,YkuD SRD1_k127_5185541_2 1254432.SCE1572_50535 2.424e-108 361.0 COG1879@1|root,COG1879@2|Bacteria,1MU95@1224|Proteobacteria 1224|Proteobacteria G Periplasmic binding protein LacI transcriptional regulator alsB - - ko:K10439 ko02010,ko02030,map02010,map02030 M00212 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 - - Peripla_BP_4 SRD1_k127_5185541_1 794903.OPIT5_17290 1.064e-166 538.0 COG1129@1|root,COG1129@2|Bacteria,46UQP@74201|Verrucomicrobia,3K90Q@414999|Opitutae 414999|Opitutae G ATPases associated with a variety of cellular activities - - 3.6.3.17 ko:K10441 ko02010,map02010 M00212 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 - - ABC_tran SRD1_k127_5189036_1 515635.Dtur_1733 4.941e-197 621.0 COG2407@1|root,COG2407@2|Bacteria 2|Bacteria G Converts the aldose L-fucose into the corresponding ketose L-fuculose - - - - - - - - - - - - Fucose_iso_C SRD1_k127_5189036_2 926550.CLDAP_13620 1.383e-121 399.0 COG1063@1|root,COG1063@2|Bacteria,2G7MF@200795|Chloroflexi 200795|Chloroflexi C PFAM Alcohol dehydrogenase GroES domain protein - - 1.1.1.14 ko:K00008 ko00040,ko00051,ko01100,map00040,map00051,map01100 M00014 R00875,R01896 RC00085,RC00102 ko00000,ko00001,ko00002,ko01000 - - - ADH_N,ADH_N_assoc,ADH_zinc_N SRD1_k127_5189036_0 1123248.KB893318_gene4215 2.719e-229 720.0 COG3534@1|root,COG3534@2|Bacteria,4NECK@976|Bacteroidetes,1IP52@117747|Sphingobacteriia 976|Bacteroidetes G Alpha-L-arabinofuranosidase domain protein - - 3.2.1.55 ko:K01209 ko00520,map00520 - R01762 - ko00000,ko00001,ko01000 - GH51 - Alpha-L-AF_C SRD1_k127_5201263_0 1191523.MROS_0285 5.88e-211 673.0 2E09V@1|root,32VXB@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - SRD1_k127_5203281_2 1123278.KB893581_gene976 1.686e-115 389.0 COG0577@1|root,COG0577@2|Bacteria,4NDUK@976|Bacteroidetes,47JJN@768503|Cytophagia 976|Bacteroidetes V FtsX-like permease family - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD SRD1_k127_5203281_0 471854.Dfer_1539 4.117e-189 618.0 COG0577@1|root,COG0577@2|Bacteria,4NDUK@976|Bacteroidetes,47MUE@768503|Cytophagia 976|Bacteroidetes V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD SRD1_k127_5203281_5 1121904.ARBP01000010_gene2430 3.16e-14 75.0 2E1JK@1|root,32WX8@2|Bacteria,4NTME@976|Bacteroidetes,47RMM@768503|Cytophagia 976|Bacteroidetes - - - - - - - - - - - - - - - SRD1_k127_5203281_3 926549.KI421517_gene187 1.529e-104 344.0 COG1136@1|root,COG1136@2|Bacteria,4NEC5@976|Bacteroidetes,47N33@768503|Cytophagia 976|Bacteroidetes V ABC transporter - - - - - - - - - - - - ABC_tran SRD1_k127_5203281_1 1047013.AQSP01000104_gene1418 7.246e-134 442.0 COG0845@1|root,COG0845@2|Bacteria 2|Bacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K02005 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 SRD1_k127_5203281_4 761193.Runsl_1952 1.076e-47 183.0 COG0577@1|root,COG0577@2|Bacteria,4NDUK@976|Bacteroidetes,47N0R@768503|Cytophagia 976|Bacteroidetes V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD SRD1_k127_5230257_4 745411.B3C1_09363 6.456e-45 170.0 COG0366@1|root,COG0366@2|Bacteria,1MU90@1224|Proteobacteria,1RQ1S@1236|Gammaproteobacteria,1J4CE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Alpha-amylase domain - - 3.2.1.135 ko:K21575 - - - - ko00000,ko01000 - GH13 - Alpha-amylase,Cyc-maltodext_C,Cyc-maltodext_N SRD1_k127_5230257_0 1121930.AQXG01000002_gene2395 1.792e-282 880.0 COG0488@1|root,COG0488@2|Bacteria,4NES5@976|Bacteroidetes,1IQQ4@117747|Sphingobacteriia 976|Bacteroidetes S ABC transporter - - - - - - - - - - - - ABC_tran,ABC_tran_Xtn SRD1_k127_5230257_3 945713.IALB_0353 1.257e-91 310.0 COG0101@1|root,COG0101@2|Bacteria 2|Bacteria J tRNA pseudouridine synthase activity truA GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 5.4.99.12 ko:K06173 - - - - ko00000,ko01000,ko03016 - - - PseudoU_synth_1 SRD1_k127_5230257_1 1356852.N008_07175 3.233e-178 575.0 COG5267@1|root,COG5267@2|Bacteria,4NHSB@976|Bacteroidetes,47MD4@768503|Cytophagia 976|Bacteroidetes S Protein of unknown function (DUF1800) - - - - - - - - - - - - DUF1800 SRD1_k127_5230257_2 1121957.ATVL01000008_gene4603 1.507e-167 542.0 COG4102@1|root,COG4102@2|Bacteria,4NFFC@976|Bacteroidetes,47MU2@768503|Cytophagia 976|Bacteroidetes S Protein of unknown function (DUF1501) - - - - - - - - - - - - DUF1501 SRD1_k127_525449_0 1191523.MROS_0470 8.761e-127 409.0 COG0591@1|root,COG0591@2|Bacteria 2|Bacteria E symporter activity sglT - - ko:K03307 - - - - ko00000 2.A.21 - - SSF SRD1_k127_525449_1 234267.Acid_0403 2.505e-65 234.0 COG0509@1|root,COG0509@2|Bacteria 2|Bacteria E glycine decarboxylation via glycine cleavage system gcvH - - ko:K02437 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221 RC00022,RC02834 ko00000,ko00001,ko00002 - - - GCV_H,Response_reg SRD1_k127_525449_3 207559.Dde_2932 3.588e-05 48.0 COG3474@1|root,COG3474@2|Bacteria,1QUNA@1224|Proteobacteria,42PVG@68525|delta/epsilon subdivisions,2WJ7N@28221|Deltaproteobacteria,2M95U@213115|Desulfovibrionales 28221|Deltaproteobacteria C PFAM cytochrome c class III - - - - - - - - - - - - Cytochrom_CIII,Cytochrome_C7 SRD1_k127_526051_3 1191523.MROS_0518 4.242e-26 126.0 COG1404@1|root,COG4677@1|root,COG1404@2|Bacteria,COG4677@2|Bacteria 2|Bacteria G pectinesterase activity - - - - - - - - - - - - Beta_helix,NosD,Pectate_lyase_3,fn3 SRD1_k127_526051_0 278957.ABEA03000005_gene4380 7.4e-169 543.0 COG0407@1|root,COG0407@2|Bacteria,46WW7@74201|Verrucomicrobia 74201|Verrucomicrobia H Uroporphyrinogen decarboxylase (URO-D) - - 4.1.1.37 ko:K01599 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000 - - - URO-D SRD1_k127_526051_2 543913.D521_2029 1.329e-43 162.0 2DM6D@1|root,31WQ8@2|Bacteria,1MZ7P@1224|Proteobacteria,2VUHB@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - SRD1_k127_526051_1 997346.HMPREF9374_1821 4.71e-81 296.0 COG5373@1|root,COG5373@2|Bacteria,1UUGX@1239|Firmicutes,4IRFV@91061|Bacilli,27BU9@186824|Thermoactinomycetaceae 91061|Bacilli S Predicted membrane protein (DUF2339) - - - - - - - - - - - - DUF2339 SRD1_k127_5262201_0 867900.Celly_0996 4.019e-87 292.0 COG4805@1|root,COG4805@2|Bacteria,4NJ6P@976|Bacteroidetes 976|Bacteroidetes S Protein conserved in bacteria - - - - - - - - - - - - - SRD1_k127_5262201_2 1121904.ARBP01000033_gene3215 1.91e-75 261.0 COG0745@1|root,COG0745@2|Bacteria,4NF1I@976|Bacteroidetes,47KCE@768503|Cytophagia 976|Bacteroidetes T PFAM response regulator receiver rprY - - - - - - - - - - - Response_reg,Trans_reg_C SRD1_k127_5262201_1 1123277.KB893185_gene3015 5.368e-84 301.0 COG5002@1|root,COG5002@2|Bacteria,4PKBV@976|Bacteroidetes,47MII@768503|Cytophagia 976|Bacteroidetes T PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - 2.7.13.3 ko:K07636 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA SRD1_k127_5262201_4 1229172.JQFA01000004_gene384 0.0003158 49.0 COG0265@1|root,COG0265@2|Bacteria,1G17C@1117|Cyanobacteria,1H723@1150|Oscillatoriales 1117|Cyanobacteria O PDZ domain (Also known as DHR or GLGF) hhoA GO:0003674,GO:0005488,GO:0005515,GO:0042802 - - - - - - - - - - PDZ_2,Trypsin_2 SRD1_k127_5262201_3 1235803.C825_05280 1.594e-10 68.0 COG1470@1|root,COG1470@2|Bacteria 2|Bacteria S cell adhesion involved in biofilm formation - - - - - - - - - - - - DUF4384,DUF4625,NPCBM_assoc,PEGA SRD1_k127_5277612_4 797302.Halru_2437 1.207e-12 75.0 COG1361@1|root,COG1520@1|root,COG3291@1|root,COG3979@1|root,arCOG02088@1|root,arCOG07560@1|root,arCOG10954@1|root,arCOG02088@2157|Archaea,arCOG02492@2157|Archaea,arCOG02508@2157|Archaea,arCOG04400@2157|Archaea,arCOG07560@2157|Archaea,arCOG07581@2157|Archaea,arCOG10954@2157|Archaea,2Y7Q0@28890|Euryarchaeota,23SYZ@183963|Halobacteria 183963|Halobacteria M COG1520 FOG WD40-like repeat - - - - - - - - - - - - CARDB,CarboxypepD_reg,PKD,PQQ_2,PQQ_3 SRD1_k127_5277612_1 945713.IALB_2344 2.641e-75 263.0 COG0664@1|root,COG0664@2|Bacteria 2|Bacteria T cyclic nucleotide binding - - - ko:K01420,ko:K10914 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 - - - ko00000,ko00001,ko03000 - - - HTH_Crp_2,cNMP_binding SRD1_k127_5277612_0 1191523.MROS_1918 4.401e-83 284.0 COG0613@1|root,COG0613@2|Bacteria 2|Bacteria Q PHP domain protein - - 3.1.3.97,4.1.2.13 ko:K01624,ko:K07053 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167,M00344,M00345 R00188,R01068,R01070,R01829,R02568,R11188 RC00078,RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 - - - PHP SRD1_k127_5277612_2 1123325.JHUV01000002_gene125 2.837e-58 207.0 COG0054@1|root,COG0054@2|Bacteria,2G3YV@200783|Aquificae 200783|Aquificae H Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin ribH GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 ko:K00794 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R04457 RC00960 ko00000,ko00001,ko00002,ko01000 - - - DMRL_synthase SRD1_k127_5277612_3 1519464.HY22_08800 4.301e-34 149.0 COG3292@1|root,COG3292@2|Bacteria,1FETN@1090|Chlorobi 1090|Chlorobi T Two component regulator propeller - - - - - - - - - - - - - SRD1_k127_5285760_1 864051.BurJ1DRAFT_4139 9.576e-17 83.0 COG1086@1|root,COG2148@1|root,COG1086@2|Bacteria,COG2148@2|Bacteria,1MV6W@1224|Proteobacteria,2VQBN@28216|Betaproteobacteria,1KKM2@119065|unclassified Burkholderiales 28216|Betaproteobacteria M Sugar transferase bplG - - - - - - - - - - - Bac_transf SRD1_k127_5285760_0 945713.IALB_2578 3e-175 567.0 COG2730@1|root,COG2730@2|Bacteria 2|Bacteria G polysaccharide catabolic process - - 3.2.1.4 ko:K01179 ko00500,ko01100,map00500,map01100 - R06200,R11307,R11308 - ko00000,ko00001,ko01000 - GH5,GH9 - CBM_6,Cellulase SRD1_k127_5294534_0 761193.Runsl_4744 4.268e-158 522.0 COG0383@1|root,COG0383@2|Bacteria,4NEC3@976|Bacteroidetes,47NE0@768503|Cytophagia 976|Bacteroidetes G Glycosyl hydrolases family 38 C-terminal domain - - 3.2.1.24 ko:K01191 ko00511,map00511 - - - ko00000,ko00001,ko01000,ko04131 - GH38 - Glyco_hydro_38,Glyco_hydro_38C SRD1_k127_5294534_1 272134.KB731324_gene4071 1.3e-107 364.0 COG0726@1|root,COG0726@2|Bacteria,1G3JU@1117|Cyanobacteria,1HABD@1150|Oscillatoriales 1117|Cyanobacteria G Polysaccharide deacetylase - - - - - - - - - - - - Polysacc_deac_1 SRD1_k127_5294534_5 497965.Cyan7822_2775 2.241e-05 57.0 COG3463@1|root,COG3463@2|Bacteria,1G0WX@1117|Cyanobacteria,3KFY9@43988|Cyanothece 1117|Cyanobacteria S Predicted membrane protein (DUF2079) - - - - - - - - - - - - DUF2079 SRD1_k127_5294534_2 926550.CLDAP_40310 7.299e-56 208.0 COG0438@1|root,COG0438@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups - - - ko:K16703 - - - - ko00000,ko01000,ko01003 - GT4 - Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 SRD1_k127_5294534_3 944435.AXAJ01000006_gene3680 1.289e-41 169.0 COG0438@1|root,COG0438@2|Bacteria,1MVA7@1224|Proteobacteria,2VM0Z@28216|Betaproteobacteria,1K0MP@119060|Burkholderiaceae 28216|Betaproteobacteria M PFAM glycosyl transferase group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 SRD1_k127_5294534_4 585529.HMPREF0291_11236 1.63e-21 102.0 COG0438@1|root,COG0438@2|Bacteria,2GM6D@201174|Actinobacteria,22KCT@1653|Corynebacteriaceae 201174|Actinobacteria M Glycosyltransferase, group 1 family protein pimB GO:0000009,GO:0000030,GO:0003674,GO:0003824,GO:0004376,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0033164,GO:0040007,GO:0043750,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0070085,GO:0071704,GO:0071944,GO:0097502,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.4.1.346 ko:K13668 - - R11703,R11704 - ko00000,ko01000,ko01003 - GT4 - Glyco_transf_4,Glycos_transf_1 SRD1_k127_5306770_0 1047013.AQSP01000106_gene1756 5.671e-186 606.0 2DBZP@1|root,2ZC2R@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - SRD1_k127_5306770_1 697281.Mahau_0032 2.721e-59 211.0 COG0407@1|root,COG0407@2|Bacteria,1V5KX@1239|Firmicutes,24IAR@186801|Clostridia 186801|Clostridia H Uroporphyrinogen decarboxylase (URO-D) - - - - - - - - - - - - URO-D SRD1_k127_5320694_2 1068978.AMETH_6131 5.054e-21 97.0 COG0673@1|root,COG0673@2|Bacteria 2|Bacteria S inositol 2-dehydrogenase activity - - - - - - - - - - - - GFO_IDH_MocA SRD1_k127_5320694_0 1385511.N783_16840 2.066e-41 169.0 COG1653@1|root,COG1653@2|Bacteria,1UZ1W@1239|Firmicutes,4HD9Q@91061|Bacilli,2YBVS@289201|Pontibacillus 91061|Bacilli G ABC transporter substrate-binding protein - - - ko:K02027 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - SBP_bac_1,SBP_bac_8 SRD1_k127_5320694_1 1267535.KB906767_gene2278 4.259e-22 106.0 COG0388@1|root,COG0388@2|Bacteria 2|Bacteria S hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds - - - - - - - - - - - - CN_hydrolase SRD1_k127_5320694_3 1457250.BBMO01000002_gene2072 4.389e-12 77.0 COG1520@1|root,arCOG02556@2157|Archaea,2XW47@28890|Euryarchaeota,23U0N@183963|Halobacteria 183963|Halobacteria S COG1520 FOG WD40-like repeat - - - - - - - - - - - - PQQ_2 SRD1_k127_5338653_3 204669.Acid345_2910 1.262e-103 344.0 COG2271@1|root,COG2271@2|Bacteria,3Y2VG@57723|Acidobacteria,2JIWZ@204432|Acidobacteriia 204432|Acidobacteriia G Major Facilitator Superfamily - - - ko:K08191 - - - - ko00000,ko02000 2.A.1.14.2 - - MFS_1 SRD1_k127_5338653_5 589865.DaAHT2_2624 3.575e-59 212.0 COG3040@1|root,COG3040@2|Bacteria,1RDAI@1224|Proteobacteria,43B7V@68525|delta/epsilon subdivisions,2X6MA@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Lipocalin / cytosolic fatty-acid binding protein family - - - ko:K03098 - - - - ko00000,ko04147 - - - Lipocalin_2 SRD1_k127_5338653_0 1121468.AUBR01000001_gene579 4.994e-197 623.0 COG1115@1|root,COG1115@2|Bacteria,1TNZP@1239|Firmicutes,247S6@186801|Clostridia,42FA0@68295|Thermoanaerobacterales 186801|Clostridia E amino acid carrier protein - - - ko:K03310 - - - - ko00000 2.A.25 - - Na_Ala_symp SRD1_k127_5338653_4 1230343.CANP01000008_gene939 2.136e-73 252.0 COG0431@1|root,COG0431@2|Bacteria,1RAFI@1224|Proteobacteria,1S3MG@1236|Gammaproteobacteria,1JDG0@118969|Legionellales 118969|Legionellales S Flavodoxin-like fold yieF - - ko:K19784 - - - - ko00000 - - - FMN_red SRD1_k127_5338653_2 1122931.AUAE01000004_gene3058 2.76e-134 436.0 COG0407@1|root,COG0407@2|Bacteria 2|Bacteria H Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III - - 4.1.1.37 ko:K01599 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000 - - - URO-D SRD1_k127_5338653_6 1173027.Mic7113_6108 2.346e-55 209.0 COG4632@1|root,COG4632@2|Bacteria,1G30P@1117|Cyanobacteria,1HDHM@1150|Oscillatoriales 1117|Cyanobacteria G Exopolysaccharide biosynthesis protein - - - - - - - - - - - - NAGPA SRD1_k127_5338653_8 1286171.EAL2_c15250 4.184e-20 96.0 COG1371@1|root,COG1371@2|Bacteria,1VX66@1239|Firmicutes,252E3@186801|Clostridia 186801|Clostridia S Archease protein family (MTH1598/TM1083) - - - - - - - - - - - - Archease SRD1_k127_5338653_7 694430.Natoc_0424 2.514e-20 96.0 COG0529@1|root,arCOG01040@2157|Archaea,2XY3W@28890|Euryarchaeota,23W77@183963|Halobacteria 183963|Halobacteria P Catalyzes the synthesis of activated sulfate - - - - - - - - - - - - AAA_33 SRD1_k127_5338653_1 517417.Cpar_0618 5.038e-178 573.0 COG1690@1|root,COG1690@2|Bacteria,1FFHX@1090|Chlorobi 1090|Chlorobi S tRNA-splicing ligase RtcB rtcB - 6.5.1.3 ko:K14415 - - - - ko00000,ko01000,ko03016 - - - RtcB SRD1_k127_5355680_0 1121904.ARBP01000026_gene677 8.057e-114 388.0 COG4249@1|root,COG4249@2|Bacteria,4PM92@976|Bacteroidetes,47YMY@768503|Cytophagia 976|Bacteroidetes S Caspase domain - - - - - - - - - - - - Peptidase_C14 SRD1_k127_5355680_4 768670.Calni_0858 8.163e-09 66.0 COG1470@1|root,COG1470@2|Bacteria 2|Bacteria S cell adhesion involved in biofilm formation - - - - - - - - - - - - CHU_C,CarbopepD_reg_2,DUF4384,NPCBM,Plug,SBBP SRD1_k127_5355680_1 880073.Calab_2906 9.55e-91 317.0 COG1305@1|root,COG1305@2|Bacteria 2|Bacteria E Transglutaminase-like superfamily MA20_22505 - - - - - - - - - - - Transglut_core SRD1_k127_5355680_3 1244869.H261_05674 1.079e-17 94.0 2EKD8@1|root,33E3I@2|Bacteria,1NJY6@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - LPP20 SRD1_k127_535916_1 1191523.MROS_2033 1.303e-75 259.0 COG1005@1|root,COG1005@2|Bacteria 2|Bacteria C quinone binding nuoH - 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADHdh SRD1_k127_535916_0 945713.IALB_0893 2.635e-133 436.0 COG1034@1|root,COG3383@1|root,COG1034@2|Bacteria,COG3383@2|Bacteria 2|Bacteria C formate dehydrogenase (NAD+) activity nuoG - 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer2_4,Fer4,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 SRD1_k127_5385876_1 1500893.JQNB01000001_gene2143 1.106e-35 148.0 COG0500@1|root,COG2226@2|Bacteria,1R8N9@1224|Proteobacteria,1SYVC@1236|Gammaproteobacteria,1X2Z5@135614|Xanthomonadales 135614|Xanthomonadales Q Methyltransferase - - - - - - - - - - - - Methyltransf_25 SRD1_k127_5385876_0 479434.Sthe_3413 1.894e-179 574.0 COG1032@1|root,COG1032@2|Bacteria,2G6ZI@200795|Chloroflexi 200795|Chloroflexi C SMART Elongator protein 3 MiaB NifB - - - - - - - - - - - - B12-binding,Radical_SAM SRD1_k127_5385876_2 945713.IALB_2767 8.137e-22 101.0 COG1708@1|root,COG1708@2|Bacteria 2|Bacteria S nucleotidyltransferase activity - - - - - - - - - - - - KNTase_C,NTP_transf_2 SRD1_k127_5395249_0 945713.IALB_2273 1.207e-58 206.0 COG1704@1|root,COG1704@2|Bacteria 2|Bacteria S LemA family lemA - - ko:K03744 - - - - ko00000 - - - LemA SRD1_k127_5395249_1 1121918.ARWE01000001_gene3055 5.533e-48 183.0 COG1512@1|root,COG1512@2|Bacteria,1PB41@1224|Proteobacteria,42R0Q@68525|delta/epsilon subdivisions,2WN87@28221|Deltaproteobacteria,43S55@69541|Desulfuromonadales 28221|Deltaproteobacteria S TPM domain - - - ko:K06872 - - - - ko00000 - - - TPM_phosphatase SRD1_k127_5395249_2 1123487.KB892835_gene3710 9.869e-05 55.0 COG0642@1|root,COG5002@1|root,COG0642@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,2WGK9@28216|Betaproteobacteria 28216|Betaproteobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,Response_reg SRD1_k127_5398207_0 1234364.AMSF01000013_gene633 8.434e-60 216.0 COG3975@1|root,COG3975@2|Bacteria,1MUHZ@1224|Proteobacteria,1RR50@1236|Gammaproteobacteria,1X5B4@135614|Xanthomonadales 135614|Xanthomonadales S M61 glycyl aminopeptidase - - - - - - - - - - - - PDZ_2,Peptidase_M61 SRD1_k127_5411001_3 204669.Acid345_4390 2.696e-32 128.0 COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y69R@57723|Acidobacteria,2JKIQ@204432|Acidobacteriia 204432|Acidobacteriia KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PD40,Pkinase SRD1_k127_5411001_0 1047013.AQSP01000073_gene1093 2.759e-132 437.0 COG0520@1|root,COG0520@2|Bacteria 2|Bacteria E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine cefD - - - - - - - - - - - Aminotran_5 SRD1_k127_5411001_1 485913.Krac_10225 1.425e-64 229.0 COG5662@1|root,COG5662@2|Bacteria 2|Bacteria K AntiSigma factor - - - - - - - - - - - - zf-HC2 SRD1_k127_5411001_2 485913.Krac_10224 7.731e-54 194.0 COG1595@1|root,COG1595@2|Bacteria 2|Bacteria K DNA-templated transcription, initiation - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 SRD1_k127_5411001_4 700598.Niako_0641 2.124e-31 127.0 COG1409@1|root,COG1409@2|Bacteria 2|Bacteria S acid phosphatase activity - - - - - - - - - - - - Metallophos SRD1_k127_5433082_4 290512.Paes_0829 5.864e-13 70.0 COG2259@1|root,COG2259@2|Bacteria,1FF61@1090|Chlorobi 1090|Chlorobi S PFAM DoxX family protein - - - ko:K15977 - - - - ko00000 - - - DoxX SRD1_k127_5433082_2 880073.Calab_0097 5.957e-78 267.0 COG4099@1|root,COG4099@2|Bacteria,2NQ8A@2323|unclassified Bacteria 2|Bacteria S Phospholipase/Carboxylesterase - - - - - - - - - - - - Abhydrolase_2,Esterase,Esterase_phd,Peptidase_S9 SRD1_k127_5433082_3 1047013.AQSP01000095_gene2301 3.359e-22 111.0 2DS9E@1|root,32VU1@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - SRD1_k127_5433082_0 761193.Runsl_4000 2.027e-217 707.0 COG4206@1|root,COG4206@2|Bacteria,4PKFW@976|Bacteroidetes,47Y2Y@768503|Cytophagia 976|Bacteroidetes H Outer membrane protein beta-barrel family - - - - - - - - - - - - CarbopepD_reg_2,CarboxypepD_reg,OMP_b-brl_3 SRD1_k127_5433082_1 1121904.ARBP01000005_gene4611 1.269e-84 286.0 COG0135@1|root,COG0135@2|Bacteria,4NK5D@976|Bacteroidetes,47NUD@768503|Cytophagia 976|Bacteroidetes E N-(5'phosphoribosyl)anthranilate (PRA) isomerase - - 5.3.1.24 ko:K01817 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03509 RC00945 ko00000,ko00001,ko00002,ko01000 - - - PRAI SRD1_k127_5449537_1 1237149.C900_02536 1.546e-78 273.0 COG0745@1|root,COG0745@2|Bacteria,4NIQC@976|Bacteroidetes,47PG7@768503|Cytophagia 976|Bacteroidetes K COGs COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - ko:K07667 ko02020,ko02024,map02020,map02024 M00454 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C SRD1_k127_5449537_0 694427.Palpr_2667 1.339e-241 776.0 COG0642@1|root,COG2205@2|Bacteria,4NEZM@976|Bacteroidetes,2FN1Z@200643|Bacteroidia,22X0P@171551|Porphyromonadaceae 976|Bacteroidetes T Osmosensitive K+ channel His kinase sensor domain - - 2.7.13.3 ko:K07646 ko02020,map02020 M00454 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - DUF4118,HATPase_c,HisKA,KdpD SRD1_k127_5449537_2 1254432.SCE1572_09220 6.175e-69 239.0 COG2156@1|root,COG2156@2|Bacteria,1RABG@1224|Proteobacteria,42SC9@68525|delta/epsilon subdivisions,2WPDZ@28221|Deltaproteobacteria,2YZWX@29|Myxococcales 28221|Deltaproteobacteria P Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex kdpC GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044425,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132 3.6.3.12 ko:K01548 ko02020,map02020 - - - ko00000,ko00001,ko01000 3.A.3.7 - - KdpC SRD1_k127_5449537_3 926566.Terro_2622 2.239e-21 97.0 COG2060@1|root,COG2060@2|Bacteria,3Y2YP@57723|Acidobacteria,2JIFM@204432|Acidobacteriia 204432|Acidobacteriia P Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane kdpA - 3.6.3.12 ko:K01546 ko02020,map02020 - - - ko00000,ko00001,ko01000 3.A.3.7 - - KdpA SRD1_k127_5455343_0 1313301.AUGC01000001_gene1464 9.488e-185 592.0 COG0606@1|root,COG0606@2|Bacteria,4NE0G@976|Bacteroidetes 976|Bacteroidetes O magnesium chelatase comM - - ko:K07391 - - - - ko00000 - - - ChlI,Mg_chelatase,Mg_chelatase_C SRD1_k127_5455343_2 706587.Desti_2948 1.191e-85 302.0 COG0069@1|root,COG0069@2|Bacteria 2|Bacteria E glutamate synthase activity - - - - - - - - - - - - Fer4,Glu_synthase SRD1_k127_5455343_1 706587.Desti_2949 1.049e-109 366.0 COG0069@1|root,COG1145@1|root,COG0069@2|Bacteria,COG1145@2|Bacteria,1MU7B@1224|Proteobacteria,42MF7@68525|delta/epsilon subdivisions,2WJBR@28221|Deltaproteobacteria 28221|Deltaproteobacteria E Glutamate synthase - - - - - - - - - - - - Fer4,Glu_synthase SRD1_k127_5463306_1 1191523.MROS_0430 2.487e-41 172.0 COG0457@1|root,COG1729@1|root,COG0457@2|Bacteria,COG1729@2|Bacteria 2|Bacteria S protein trimerization - - - - - - - - - - - - TPR_16,TPR_19,TPR_2,TPR_6,TPR_8 SRD1_k127_5463306_2 290512.Paes_1146 7.655e-09 64.0 COG3678@1|root,COG3678@2|Bacteria,1FFH3@1090|Chlorobi 1090|Chlorobi NPTU LTXXQ motif family protein - - - - - - - - - - - - Metal_resist SRD1_k127_5463306_0 880073.Calab_0511 2.067e-52 193.0 COG4221@1|root,COG4221@2|Bacteria,2NPJV@2323|unclassified Bacteria 2|Bacteria S Belongs to the short-chain dehydrogenases reductases (SDR) family - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short SRD1_k127_5473746_3 1289387.AUKW01000011_gene740 5.852e-29 122.0 COG4608@1|root,COG4608@2|Bacteria,2H4BW@201174|Actinobacteria 201174|Actinobacteria E Belongs to the ABC transporter superfamily - - - ko:K02032 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY SRD1_k127_5473746_1 644966.Tmar_0688 3.601e-55 206.0 COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,247NN@186801|Clostridia 186801|Clostridia P Belongs to the ABC transporter superfamily - - - ko:K02031,ko:K02032,ko:K15583 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - ABC_tran,oligo_HPY SRD1_k127_5473746_0 517418.Ctha_1641 7.676e-132 440.0 COG0747@1|root,COG0747@2|Bacteria,1FD6U@1090|Chlorobi 1090|Chlorobi E PFAM extracellular solute-binding protein, family 5 - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 SRD1_k127_5473746_2 340177.Cag_1766 6.443e-43 171.0 COG0601@1|root,COG0601@2|Bacteria,1FDDB@1090|Chlorobi 1090|Chlorobi P PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 SRD1_k127_5484511_0 1191523.MROS_0617 2.431e-110 366.0 COG1313@1|root,COG1313@2|Bacteria 2|Bacteria C radical SAM domain protein - - 1.97.1.4 ko:K04070 - - - - ko00000,ko01000 - - - Fer4_12,Fer4_14,Radical_SAM SRD1_k127_5484511_3 926554.KI912636_gene3089 3.112e-47 177.0 COG2318@1|root,COG2318@2|Bacteria 2|Bacteria S DinB family yfiT - - - - - - - - - - - DinB_2 SRD1_k127_5484511_1 1121423.JONT01000013_gene348 2.492e-60 214.0 COG0461@1|root,COG0461@2|Bacteria,1V1BZ@1239|Firmicutes,25CGM@186801|Clostridia,261GR@186807|Peptococcaceae 186801|Clostridia F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) pyrE - 2.4.2.10 ko:K00762 ko00240,ko01100,map00240,map01100 M00051 R01870 RC00611 ko00000,ko00001,ko00002,ko01000 - - - Pribosyltran SRD1_k127_5484511_2 945713.IALB_2972 1.395e-51 192.0 COG0494@1|root,COG0494@2|Bacteria 2|Bacteria L nUDIX hydrolase nudF - 3.6.1.13 ko:K01515 ko00230,map00230 - R01054 RC00002 ko00000,ko00001,ko01000 - - iHN637.CLJU_RS05505,iSB619.SA_RS07540,iYO844.BSU23610 NUDIX SRD1_k127_5490961_3 517418.Ctha_0103 7.763e-54 205.0 COG0535@1|root,COG0535@2|Bacteria 2|Bacteria I radical SAM domain protein - - - - - - - - - - - - Fer4_12,Fer4_14,Radical_SAM,SPASM SRD1_k127_5490961_6 1242864.D187_002906 1.609e-07 63.0 COG0671@1|root,COG0671@2|Bacteria,1QFZ7@1224|Proteobacteria 1224|Proteobacteria I PAP2 superfamily - - - - - - - - - - - - PAP2_3 SRD1_k127_5490961_4 706587.Desti_1825 1.863e-47 185.0 COG1748@1|root,COG1748@2|Bacteria,1NIU2@1224|Proteobacteria,42MHS@68525|delta/epsilon subdivisions,2WJQW@28221|Deltaproteobacteria 28221|Deltaproteobacteria E PFAM Saccharopine dehydrogenase - - - - - - - - - - - - Sacchrp_dh_C,Sacchrp_dh_NADP SRD1_k127_5490961_2 485913.Krac_0275 3.583e-76 265.0 COG1028@1|root,COG1028@2|Bacteria,2G660@200795|Chloroflexi 200795|Chloroflexi IQ COGs COG1028 Dehydrogenase with different specificities (related to short-chain alcohol dehydrogenase) - - - - - - - - - - - - adh_short SRD1_k127_5490961_0 309799.DICTH_0538 6.048e-140 456.0 COG0156@1|root,COG0156@2|Bacteria 2|Bacteria E 8-amino-7-oxononanoate synthase activity bioF GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 2.3.1.29,2.3.1.47 ko:K00639,ko:K00652 ko00260,ko00780,ko01100,map00260,map00780,map01100 M00123,M00573,M00577 R00371,R03210,R10124 RC00004,RC00039,RC00394,RC02725 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 SRD1_k127_5490961_1 452637.Oter_2906 1.807e-126 426.0 2CC7E@1|root,32M7R@2|Bacteria,46UM2@74201|Verrucomicrobia,3K8H5@414999|Opitutae 414999|Opitutae - - - - - - - - - - - - - - - SRD1_k127_5490961_5 357808.RoseRS_1547 3.513e-27 117.0 COG4447@1|root,COG4447@2|Bacteria,2G66V@200795|Chloroflexi,3767C@32061|Chloroflexia 32061|Chloroflexia G glycosyl hydrolase, BNR repeat-containing protein - - - - - - - - - - - - - SRD1_k127_5497880_0 945713.IALB_0304 2.837e-256 800.0 COG0574@1|root,COG0784@1|root,COG0574@2|Bacteria,COG0784@2|Bacteria 2|Bacteria T Response regulator, receiver - - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PPDK_N,Response_reg,SpoIIE SRD1_k127_5497880_2 395493.BegalDRAFT_0294 7.644e-29 119.0 COG3695@1|root,COG3695@2|Bacteria,1N7J2@1224|Proteobacteria,1SCIZ@1236|Gammaproteobacteria,463F1@72273|Thiotrichales 72273|Thiotrichales L PFAM 6-O-methylguanine DNA methyltransferase, DNA binding domain - - - ko:K07443 - - - - ko00000 - - - DNA_binding_1 SRD1_k127_5497880_1 945713.IALB_1143 1.757e-158 502.0 COG0365@1|root,COG0365@2|Bacteria 2|Bacteria I Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA acs - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C SRD1_k127_5530374_2 1121104.AQXH01000005_gene164 2.044e-21 98.0 COG1404@1|root,COG5276@1|root,COG1404@2|Bacteria,COG5276@2|Bacteria,4PPJ4@976|Bacteroidetes,1IZ3E@117747|Sphingobacteriia 2|Bacteria O Protein conserved in bacteria - - - ko:K20276 ko02024,map02024 - - - ko00000,ko00001 - - - FG-GAP,LVIVD,Peptidase_S8,Phytase-like,SLH,TSP_3 SRD1_k127_5530374_0 1304880.JAGB01000002_gene1886 4.726e-185 606.0 COG3250@1|root,COG3250@2|Bacteria,1TS96@1239|Firmicutes,248B9@186801|Clostridia 186801|Clostridia G Belongs to the glycosyl hydrolase 2 family - - 3.2.1.25 ko:K01192 ko00511,ko04142,map00511,map04142 - - - ko00000,ko00001,ko01000 - - - Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N SRD1_k127_5530374_1 518766.Rmar_2615 1.379e-87 300.0 COG2152@1|root,COG2152@2|Bacteria,4NG7B@976|Bacteroidetes 976|Bacteroidetes G PFAM glycosidase, PH1107-related - - 2.4.1.339,2.4.1.340 ko:K20885 - - R11397,R11398 RC00049,RC02748 ko00000,ko01000 - GH130 - Glyco_hydro_130 SRD1_k127_5539003_0 1205753.A989_08619 3.668e-161 522.0 COG1680@1|root,COG1680@2|Bacteria,1MVZN@1224|Proteobacteria,1RP0R@1236|Gammaproteobacteria,1X55T@135614|Xanthomonadales 135614|Xanthomonadales V Beta-lactamase ampC2 - - - - - - - - - - - Beta-lactamase,DUF3471 SRD1_k127_5562603_1 278963.ATWD01000002_gene451 2.175e-44 172.0 COG1595@1|root,COG1595@2|Bacteria,3Y4KQ@57723|Acidobacteria,2JJAR@204432|Acidobacteriia 204432|Acidobacteriia K RNA polymerase sigma factor - - - - - - - - - - - - Sigma70_r2,Sigma70_r4_2 SRD1_k127_5562603_2 1185876.BN8_00342 7.202e-19 92.0 2E5Q2@1|root,330EP@2|Bacteria,4NUMS@976|Bacteroidetes,47SBQ@768503|Cytophagia 976|Bacteroidetes - - - - - - - - - - - - - - - SRD1_k127_5562603_0 1121918.ARWE01000001_gene3110 6.979e-219 692.0 COG3387@1|root,COG3387@2|Bacteria,1MYVI@1224|Proteobacteria,42YST@68525|delta/epsilon subdivisions,2WURK@28221|Deltaproteobacteria 28221|Deltaproteobacteria G Glucodextranase, domain N - - 3.2.1.3 ko:K01178 ko00500,ko01100,map00500,map01100 - R01790,R01791,R06199 - ko00000,ko00001,ko01000 - GH15 - Glucodextran_N,Glyco_hydro_15 SRD1_k127_5563533_5 1329516.JPST01000014_gene581 6.48e-07 62.0 COG0515@1|root,COG0515@2|Bacteria,1TP3F@1239|Firmicutes,4H9KD@91061|Bacilli,27B9F@186824|Thermoactinomycetaceae 91061|Bacilli KLT Serine/Threonine protein kinases, catalytic domain prkC GO:0002237,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005539,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009617,GO:0009719,GO:0009847,GO:0009987,GO:0010033,GO:0010243,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0023052,GO:0032494,GO:0032502,GO:0036211,GO:0042221,GO:0042834,GO:0043170,GO:0043207,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051704,GO:0051707,GO:0051716,GO:0065007,GO:0070887,GO:0071216,GO:0071219,GO:0071224,GO:0071310,GO:0071417,GO:0071495,GO:0071704,GO:0071944,GO:0097367,GO:0140096,GO:1901564,GO:1901698,GO:1901699,GO:1901700,GO:1901701 2.7.11.1 ko:K08884,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PASTA,Pkinase SRD1_k127_5563533_0 861299.J421_1664 3.586e-60 232.0 2E0UX@1|root,32WC9@2|Bacteria,1ZUE1@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - SRD1_k127_5563533_3 1121930.AQXG01000007_gene491 3.619e-31 139.0 COG1523@1|root,COG1649@1|root,COG4733@1|root,COG1523@2|Bacteria,COG1649@2|Bacteria,COG4733@2|Bacteria,4NHA4@976|Bacteroidetes,1IQ6P@117747|Sphingobacteriia 976|Bacteroidetes G Belongs to the glycosyl hydrolase 13 family - - - - - - - - - - - - Alpha-amylase,CBM_48,FlgD_ig SRD1_k127_5563533_1 485913.Krac_7826 1.505e-49 186.0 COG0631@1|root,COG0631@2|Bacteria,2G6R4@200795|Chloroflexi 200795|Chloroflexi T SMART protein phosphatase 2C domain protein - - 3.1.3.16 ko:K20074 - - - - ko00000,ko01000,ko01009 - - - PP2C,PP2C_2 SRD1_k127_5563533_2 1385935.N836_01540 1.797e-33 132.0 COG0662@1|root,COG0662@2|Bacteria,1GEZS@1117|Cyanobacteria 1117|Cyanobacteria G Cupin domain - - - - - - - - - - - - Cupin_2 SRD1_k127_5563533_4 1123511.KB905839_gene447 1.755e-13 78.0 29GAR@1|root,3038K@2|Bacteria,1VIKG@1239|Firmicutes,4H88K@909932|Negativicutes 909932|Negativicutes - - - - - - - - - - - - - - - SRD1_k127_5584375_0 485917.Phep_2886 1.161e-158 525.0 COG1501@1|root,COG1501@2|Bacteria 2|Bacteria G Belongs to the glycosyl hydrolase 31 family - - 3.2.1.1,3.2.1.22 ko:K01176,ko:K07407 ko00052,ko00500,ko00561,ko00600,ko00603,ko01100,ko04973,map00052,map00500,map00561,map00600,map00603,map01100,map04973 - R01101,R01103,R01104,R01194,R01329,R02108,R02112,R02926,R03634,R04019,R04470,R05549,R05961,R06091,R11262 RC00049,RC00059,RC00451 ko00000,ko00001,ko01000 - GH13 - Alpha-amylase,CBM26,CHB_HEX_C_1,Glyco_hydro_31,Melibiase SRD1_k127_5584375_1 693986.MOC_4734 4.584e-26 111.0 COG1136@1|root,COG1136@2|Bacteria,1QT8W@1224|Proteobacteria,2VF20@28211|Alphaproteobacteria,1JXIN@119045|Methylobacteriaceae 28211|Alphaproteobacteria V ATPases associated with a variety of cellular activities - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran SRD1_k127_5693846_0 595494.Tola_1907 1.676e-136 453.0 COG1080@1|root,COG1762@1|root,COG1925@1|root,COG1080@2|Bacteria,COG1762@2|Bacteria,COG1925@2|Bacteria,1MUT8@1224|Proteobacteria,1RN6R@1236|Gammaproteobacteria,1Y46S@135624|Aeromonadales 135624|Aeromonadales G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) - - 2.7.1.202,2.7.3.9 ko:K02768,ko:K08483,ko:K11183,ko:K11189,ko:K11201 ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060 M00273,M00306 R03232 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.2.1,8.A.7 - - PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C,PTS-HPr,PTS_EIIA_2 SRD1_k127_5693846_1 485913.Krac_8547 4.581e-15 81.0 2E3KN@1|root,32YIY@2|Bacteria 2|Bacteria S Protein of unknown function (DUF2630) - - - - - - - - - - - - DUF2630 SRD1_k127_5701666_2 648996.Theam_0631 2.471e-66 234.0 COG0019@1|root,COG0019@2|Bacteria,2G3J8@200783|Aquificae 200783|Aquificae E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine lysA - 4.1.1.20 ko:K01586 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R00451 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC SRD1_k127_5701666_0 648996.Theam_0349 2.801e-124 407.0 COG0136@1|root,COG0136@2|Bacteria,2G3QW@200783|Aquificae 200783|Aquificae E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate asd - 1.2.1.11 ko:K00133 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R02291 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC SRD1_k127_5701666_1 240015.ACP_2209 1.016e-69 243.0 COG1181@1|root,COG1181@2|Bacteria,3Y3HW@57723|Acidobacteria,2JI4N@204432|Acidobacteriia 204432|Acidobacteriia M Belongs to the D-alanine--D-alanine ligase family ddl - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C,Dala_Dala_lig_N SRD1_k127_5710411_0 517418.Ctha_1907 1.068e-176 568.0 COG0612@1|root,COG0612@2|Bacteria 2|Bacteria L Peptidase, M16 pqqL GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C SRD1_k127_5712738_0 1191523.MROS_1555 1.168e-241 761.0 COG1132@1|root,COG1132@2|Bacteria 2|Bacteria V (ABC) transporter MdlB - - ko:K06147,ko:K18890 ko02010,map02010 M00707 - - ko00000,ko00001,ko00002,ko02000 3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran SRD1_k127_5712738_1 945713.IALB_2639 1.171e-176 566.0 COG1132@1|root,COG1132@2|Bacteria 2|Bacteria V (ABC) transporter mdlA - - ko:K06147,ko:K18889 ko02010,map02010 M00707 - - ko00000,ko00001,ko00002,ko02000 3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran SRD1_k127_5734097_0 215803.DB30_4199 0.0 1071.0 COG3256@1|root,COG3256@2|Bacteria,1MVT1@1224|Proteobacteria,42NBM@68525|delta/epsilon subdivisions,2WKTG@28221|Deltaproteobacteria,2YWJW@29|Myxococcales 28221|Deltaproteobacteria P Cytochrome C and Quinol oxidase polypeptide I norZ - 1.7.2.5 ko:K04561 ko00910,ko01120,map00910,map01120 M00529 R00294 RC02794 ko00000,ko00001,ko00002,ko01000 3.D.4.10 - - COX1 SRD1_k127_5734097_2 935863.AWZR01000010_gene756 3.323e-21 100.0 COG2050@1|root,COG2050@2|Bacteria,1QN1J@1224|Proteobacteria,1SGAA@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q protein possibly involved in aromatic compounds catabolism - - - - - - - - - - - - 4HBT SRD1_k127_5734097_1 1408473.JHXO01000001_gene1962 7.538e-82 281.0 COG0667@1|root,COG0667@2|Bacteria,4PPAM@976|Bacteroidetes,2G14T@200643|Bacteroidia 976|Bacteroidetes C Aldo/keto reductase family - - - - - - - - - - - - Aldo_ket_red SRD1_k127_5741662_1 1521187.JPIM01000041_gene543 2.947e-06 60.0 COG2244@1|root,COG2244@2|Bacteria,2G8GU@200795|Chloroflexi 200795|Chloroflexi S virulence factor MVIN family protein - - - - - - - - - - - - Polysacc_synt,Polysacc_synt_C SRD1_k127_5741662_0 439481.Aboo_0277 7.295e-37 145.0 COG0438@1|root,arCOG01403@2157|Archaea 2157|Archaea M PFAM Glycosyl transferase, group 1 - GO:0003674,GO:0003824,GO:0016740,GO:0016757 - ko:K12996 - - - - ko00000,ko01000,ko01003,ko01005 - GT4 - DUF1972,Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1 SRD1_k127_5744959_1 452637.Oter_0946 4.864e-86 306.0 COG4251@1|root,COG5278@1|root,COG4251@2|Bacteria,COG5278@2|Bacteria,46U7H@74201|Verrucomicrobia 74201|Verrucomicrobia T PFAM ATP-binding region ATPase domain protein - - - - - - - - - - - - CHASE3,HATPase_c,HisKA SRD1_k127_5744959_0 926569.ANT_00850 1.823e-170 544.0 COG1350@1|root,COG1350@2|Bacteria,2G5YY@200795|Chloroflexi 200795|Chloroflexi E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine - - 4.2.1.20 ko:K06001 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - PALP SRD1_k127_5750864_1 997346.HMPREF9374_1243 1.126e-09 71.0 COG3387@1|root,COG3387@2|Bacteria,1TR12@1239|Firmicutes,4HD33@91061|Bacilli,27CHM@186824|Thermoactinomycetaceae 91061|Bacilli G Glycosyl hydrolases family 15 - - - - - - - - - - - - Glyco_hydro_15 SRD1_k127_5750864_0 1047013.AQSP01000142_gene205 1.86e-162 521.0 COG3408@1|root,COG3408@2|Bacteria 2|Bacteria G Glycogen debranching enzyme - - - - - - - - - - - - Bac_rhamnosid6H,Bac_rhamnosid_C,Big_4,CBM_6,Crystall,Glyco_hydro_64,RicinB_lectin_2,SLH,Trehalase SRD1_k127_5757685_6 671143.DAMO_2996 5.377e-41 163.0 COG1032@1|root,COG1032@2|Bacteria,2NQU0@2323|unclassified Bacteria 2|Bacteria C Elongator protein 3, MiaB family, Radical SAM - - - - - - - - - - - - B12-binding,Radical_SAM SRD1_k127_5757685_7 1161401.ASJA01000015_gene940 3.869e-29 128.0 COG3832@1|root,COG3832@2|Bacteria,1Q020@1224|Proteobacteria,2US81@28211|Alphaproteobacteria,43ZYV@69657|Hyphomonadaceae 28211|Alphaproteobacteria J glyoxalase III activity - - - - - - - - - - - - - SRD1_k127_5757685_5 1123229.AUBC01000024_gene4531 1.902e-47 182.0 COG0500@1|root,COG2226@2|Bacteria,1NKPP@1224|Proteobacteria 1224|Proteobacteria Q Methyltransferase domain - - - - - - - - - - - - Methyltransf_11 SRD1_k127_5757685_4 1235803.C825_00442 1.239e-57 207.0 COG2140@1|root,COG2140@2|Bacteria,4P00D@976|Bacteroidetes,2FS49@200643|Bacteroidia 976|Bacteroidetes G Glucose-6-phosphate isomerase (GPI) - - 5.3.1.9 ko:K06859 ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200 M00001,M00004,M00114 R02739,R02740,R03321 RC00376,RC00563 ko00000,ko00001,ko00002,ko01000 - - - GPI SRD1_k127_5757685_3 1166018.FAES_3605 7.549e-94 319.0 COG1940@1|root,COG1940@2|Bacteria,4NKSF@976|Bacteroidetes,47TDB@768503|Cytophagia 976|Bacteroidetes GK ROK family - - 2.7.1.2 ko:K00845 ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R01600,R01786 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - ROK SRD1_k127_5757685_0 997884.HMPREF1068_03449 1.147e-232 736.0 COG1482@1|root,COG1482@2|Bacteria,4NF9A@976|Bacteroidetes,2FNY1@200643|Bacteroidia,4AMYT@815|Bacteroidaceae 976|Bacteroidetes G Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - ROK SRD1_k127_5757685_2 268407.PWYN_04680 4.128e-104 346.0 COG2140@1|root,COG2140@2|Bacteria,1V13Z@1239|Firmicutes 1239|Firmicutes G Glucose-6-phosphate isomerase (GPI) - - 5.3.1.9 ko:K06859 ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200 M00001,M00004,M00114 R02739,R02740,R03321 RC00376,RC00563 ko00000,ko00001,ko00002,ko01000 - - - GPI SRD1_k127_5757685_1 1121930.AQXG01000002_gene2362 1.064e-135 440.0 2DBJC@1|root,2Z9K5@2|Bacteria,4P1C2@976|Bacteroidetes,1IWD2@117747|Sphingobacteriia 976|Bacteroidetes G Glycosyl hydrolase family 47 - - - - - - - - - - - - Glyco_hydro_47 SRD1_k127_5757765_2 1123248.KB893385_gene4781 5.701e-21 93.0 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,4NEP3@976|Bacteroidetes,1IYHV@117747|Sphingobacteriia 976|Bacteroidetes C PFAM Pyruvate flavodoxin ferredoxin oxidoreductase porA - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR,POR_N SRD1_k127_5757765_0 518766.Rmar_0336 1.158e-137 448.0 COG1013@1|root,COG1013@2|Bacteria,4NIE0@976|Bacteroidetes,1FIT9@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes C Thiamine pyrophosphate enzyme, C-terminal TPP binding domain oorB - 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C SRD1_k127_5757765_1 1191523.MROS_1979 4.63e-76 269.0 COG0618@1|root,COG0618@2|Bacteria 2|Bacteria S phosphoesterase RecJ domain protein nrnA GO:0008150,GO:0040007 3.1.13.3,3.1.3.7 ko:K06881 ko00920,ko01100,ko01120,map00920,map01100,map01120 - R00188,R00508 RC00078 ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1 SRD1_k127_5757765_3 350688.Clos_0278 0.0005267 51.0 COG0260@1|root,COG0260@2|Bacteria,1TPJZ@1239|Firmicutes,248KF@186801|Clostridia,36F3M@31979|Clostridiaceae 186801|Clostridia E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides pepA - 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M17,Peptidase_M17_N SRD1_k127_5760076_3 1123277.KB893179_gene3164 3.048e-41 158.0 COG2866@1|root,COG2866@2|Bacteria,4NDXH@976|Bacteroidetes,47MSA@768503|Cytophagia 976|Bacteroidetes E Zinc carboxypeptidase - - - - - - - - - - - - Peptidase_M14 SRD1_k127_5760076_0 945713.IALB_0415 9.188e-206 681.0 COG1196@1|root,COG1196@2|Bacteria 2|Bacteria D nuclear chromosome segregation - - - - - - - - - - - - - SRD1_k127_5760076_1 1191523.MROS_1087 1.11e-86 292.0 2DBN7@1|root,2ZA2Y@2|Bacteria 2|Bacteria S Domain of unknown function (DUF4159) - - - - - - - - - - - - DUF4159 SRD1_k127_5760076_2 1379698.RBG1_1C00001G0400 5.998e-55 201.0 COG0206@1|root,COG0206@2|Bacteria,2NNSU@2323|unclassified Bacteria 2|Bacteria D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity ftsZ GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0022607,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034622,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043933,GO:0044085,GO:0044424,GO:0044464,GO:0051258,GO:0051301,GO:0065003,GO:0071840,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - ko:K03531 ko04112,map04112 - - - ko00000,ko00001,ko02048,ko03036,ko04812 - - - FtsZ_C,Tubulin SRD1_k127_576188_1 945713.IALB_2662 1.216e-52 195.0 COG1807@1|root,COG1807@2|Bacteria 2|Bacteria M 4-amino-4-deoxy-L-arabinose transferase activity - - - - - - - - - - - - DUF2723,PMT,PMT_2,TPR_19 SRD1_k127_576188_0 1379698.RBG1_1C00001G1319 1.119e-103 349.0 COG0438@1|root,COG0438@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups - - - - - - - - - - - - Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 SRD1_k127_576188_3 1121920.AUAU01000026_gene1478 8.03e-45 168.0 COG2318@1|root,COG2318@2|Bacteria 2|Bacteria S DinB family - - - - - - - - - - - - DinB_2 SRD1_k127_576188_2 1191523.MROS_1414 5.668e-49 198.0 COG4206@1|root,COG4206@2|Bacteria 2|Bacteria H cobalamin-transporting ATPase activity - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Porin_10 SRD1_k127_576188_4 518766.Rmar_2623 1.683e-15 81.0 COG1947@1|root,COG1947@2|Bacteria,4NGFC@976|Bacteroidetes,1FJ7G@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes F Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol ispE GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0050515 2.7.1.148 ko:K00919 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05634 RC00002,RC01439 ko00000,ko00001,ko00002,ko01000 - - - GHMP_kinases_C,GHMP_kinases_N SRD1_k127_5765802_1 572477.Alvin_0712 2.688e-33 129.0 COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,1RPIU@1236|Gammaproteobacteria,1WVW8@135613|Chromatiales 135613|Chromatiales EF Belongs to the CarB family carB - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS SRD1_k127_5765802_0 269799.Gmet_2696 4.618e-137 446.0 COG1966@1|root,COG1966@2|Bacteria,1MWF9@1224|Proteobacteria,42NBI@68525|delta/epsilon subdivisions,2WM33@28221|Deltaproteobacteria,43TTR@69541|Desulfuromonadales 28221|Deltaproteobacteria T 5TM C-terminal transporter carbon starvation CstA cstA-2 - - ko:K06200 - - - - ko00000 - - - CstA,CstA_5TM SRD1_k127_5778141_0 102129.Lepto7375DRAFT_5349 2.342e-74 252.0 COG3676@1|root,COG3677@1|root,COG3676@2|Bacteria,COG3677@2|Bacteria,1GBBG@1117|Cyanobacteria,1HG5G@1150|Oscillatoriales 1117|Cyanobacteria L Transposase zinc-ribbon domain - - - - - - - - - - - - DDE_Tnp_IS1595,Zn_Tnp_IS1595 SRD1_k127_5778141_1 1249627.D779_0358 6.321e-63 220.0 COG3676@1|root,COG3677@1|root,COG3676@2|Bacteria,COG3677@2|Bacteria,1R7ZF@1224|Proteobacteria,1S6YQ@1236|Gammaproteobacteria,1WYGX@135613|Chromatiales 135613|Chromatiales L ISXO2-like transposase domain - - - - - - - - - - - - DDE_Tnp_IS1595,Zn_Tnp_IS1595 SRD1_k127_5790334_2 671143.DAMO_1393 1.907e-22 101.0 COG0009@1|root,COG0009@2|Bacteria,2NPMH@2323|unclassified Bacteria 2|Bacteria J Belongs to the SUA5 family prmC - 2.7.7.87 ko:K07566 - - R10463 RC00745 ko00000,ko01000,ko03009,ko03016 - - - SUA5,Sua5_yciO_yrdC SRD1_k127_5790334_1 1122915.AUGY01000077_gene1544 2.072e-95 341.0 COG1361@1|root,COG2120@1|root,COG1361@2|Bacteria,COG2120@2|Bacteria,1UYPV@1239|Firmicutes,4HCT3@91061|Bacilli,26UC7@186822|Paenibacillaceae 91061|Bacilli M NPCBM-associated, NEW3 domain of alpha-galactosidase - - - - - - - - - - - - NPCBM_assoc,PIG-L SRD1_k127_5790334_0 1329516.JPST01000003_gene1164 7.22e-98 328.0 COG1840@1|root,COG1840@2|Bacteria,1TQC3@1239|Firmicutes,4HABY@91061|Bacilli,27CM5@186824|Thermoactinomycetaceae 91061|Bacilli P Bacterial extracellular solute-binding protein - - - ko:K02012 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko02000 3.A.1.10 - - SBP_bac_6 SRD1_k127_580548_5 373903.Hore_07370 2.539e-33 134.0 COG0164@1|root,COG0164@2|Bacteria,1V1D6@1239|Firmicutes,248IT@186801|Clostridia,3WAMH@53433|Halanaerobiales 186801|Clostridia L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhB - 3.1.26.4 ko:K03470 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_HII SRD1_k127_580548_1 945713.IALB_0628 5.658e-105 363.0 COG4775@1|root,COG4775@2|Bacteria 2|Bacteria M membrane organization - - - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA SRD1_k127_580548_2 945713.IALB_0624 1.247e-75 269.0 COG4219@1|root,COG4219@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - Amidase_6,DUF4309,DUF5301 SRD1_k127_580548_0 945713.IALB_0623 2.772e-155 501.0 COG0621@1|root,COG0621@2|Bacteria 2|Bacteria J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine rimO GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016782,GO:0018193,GO:0018197,GO:0018198,GO:0018339,GO:0019538,GO:0035596,GO:0035599,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050497,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901564 2.8.4.4 ko:K14441 - - R10652 RC00003,RC03217 ko00000,ko01000,ko03009 - - - Radical_SAM,TRAM,UPF0004 SRD1_k127_580548_3 945713.IALB_0622 5.739e-61 222.0 COG4589@1|root,COG4589@2|Bacteria 2|Bacteria S phosphatidate cytidylyltransferase activity cdsA - 2.7.7.41 ko:K00981 ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070 M00093 R01799 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_1 SRD1_k127_580548_6 1191523.MROS_1630 1.3e-32 139.0 COG1266@1|root,COG1266@2|Bacteria 2|Bacteria V CAAX protease self-immunity - - - ko:K07052 - - - - ko00000 - - - Abi SRD1_k127_580548_4 497964.CfE428DRAFT_4472 3.315e-49 178.0 COG1899@1|root,COG1899@2|Bacteria 2|Bacteria O peptidyl-lysine modification to peptidyl-hypusine - - - - - - - - - - - - - SRD1_k127_5810348_2 247490.KSU1_A0077 2.734e-104 346.0 COG3259@1|root,COG3259@2|Bacteria,2IYS2@203682|Planctomycetes 203682|Planctomycetes C Nickel-dependent hydrogenase - - - - - - - - - - - - NiFeSe_Hases SRD1_k127_5810348_1 272134.KB731324_gene5863 4.27e-108 358.0 COG1941@1|root,COG1941@2|Bacteria 2|Bacteria C coenzyme F420 hydrogenase activity hoxY - - - - - - - - - - - Oxidored_q6 SRD1_k127_5810348_3 1122221.JHVI01000016_gene1615 2.527e-99 333.0 COG0543@1|root,COG0543@2|Bacteria,1WKS1@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus C PFAM Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulphur cluster binding domain - - - ko:K02823 ko00240,ko01100,map00240,map01100 - - - ko00000,ko00001 - - - DHODB_Fe-S_bind SRD1_k127_5810348_5 518766.Rmar_2587 3.244e-47 174.0 COG0664@1|root,COG0664@2|Bacteria 2|Bacteria T cyclic nucleotide binding crp - - ko:K10914 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 - - - ko00000,ko00001,ko03000 - - - cNMP_binding SRD1_k127_5810348_0 518766.Rmar_2586 1.173e-123 407.0 COG0479@1|root,COG0479@2|Bacteria 2|Bacteria C Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family asrA - - ko:K16950 ko00920,ko01120,map00920,map01120 - R00858,R10146 RC00065 ko00000,ko00001 - - - Fer4_22 SRD1_k127_5810348_4 266117.Rxyl_2676 1.203e-58 208.0 COG0177@1|root,COG0177@2|Bacteria,2GJ01@201174|Actinobacteria,4CTQB@84995|Rubrobacteria 84995|Rubrobacteria L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate nth - 4.2.99.18 ko:K10773 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,HhH-GPD SRD1_k127_5821557_0 671143.DAMO_2764 3.3e-114 375.0 COG0501@1|root,COG0501@2|Bacteria,2NP1V@2323|unclassified Bacteria 2|Bacteria O Belongs to the peptidase M48B family htpX GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - ko:K03799 - M00743 - - ko00000,ko00002,ko01000,ko01002 - - - Peptidase_M48 SRD1_k127_5821557_1 467200.ACFA01000395_gene991 5.365e-11 65.0 COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria 201174|Actinobacteria V ABC transporter - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran SRD1_k127_5829693_2 945713.IALB_3094 2.87e-76 260.0 COG0240@1|root,COG0240@2|Bacteria 2|Bacteria I glycerol-3-phosphate dehydrogenase [NAD(P)+] activity gpsA GO:0003674,GO:0003824,GO:0004367,GO:0006072,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0019637,GO:0044237,GO:0046167,GO:0047952,GO:0052646,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901576 1.1.1.94 ko:K00057 ko00564,ko01110,map00564,map01110 - R00842,R00844 RC00029 ko00000,ko00001,ko01000 - - - NAD_Gly3P_dh_C,NAD_Gly3P_dh_N SRD1_k127_5829693_0 1519464.HY22_06785 3.023e-301 941.0 COG3808@1|root,COG3808@2|Bacteria,1FD6P@1090|Chlorobi 1090|Chlorobi C Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na( ) movement across the membrane hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase SRD1_k127_5829693_1 1519464.HY22_09440 5.816e-81 273.0 COG0531@1|root,COG0531@2|Bacteria 2|Bacteria E amino acid - - - ko:K03294 - - - - ko00000 2.A.3.2 - - AA_permease_2 SRD1_k127_5853433_2 1191523.MROS_2048 1.833e-21 108.0 COG0737@1|root,COG3303@1|root,COG0737@2|Bacteria,COG3303@2|Bacteria 2|Bacteria C Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process - - 1.7.2.2 ko:K03385 ko00910,ko01120,ko05132,map00910,map01120,map05132 M00530 R05712 RC00176 ko00000,ko00001,ko00002,ko01000 - - - 5_nucleotid_C,Cytochrom_C552,Cytochrome_C554,Paired_CXXCH_1,SBP_bac_8,SLH SRD1_k127_5853433_0 237368.SCABRO_01358 1.351e-119 390.0 COG1682@1|root,COG1682@2|Bacteria,2IYXC@203682|Planctomycetes 203682|Planctomycetes U COG1682 ABC-type polysaccharide polyol phosphate export systems, permease component - - - ko:K09690 ko02010,map02010 M00250 - - ko00000,ko00001,ko00002,ko02000 3.A.1.103 - - ABC2_membrane SRD1_k127_5853433_1 107635.AZUO01000001_gene2087 2.43e-97 332.0 COG1134@1|root,COG1134@2|Bacteria,1MWWC@1224|Proteobacteria,2TU3M@28211|Alphaproteobacteria,37190@31993|Methylocystaceae 28211|Alphaproteobacteria GM ATPases associated with a variety of cellular activities - - - ko:K09691 ko02010,map02010 M00250 - - ko00000,ko00001,ko00002,ko02000 3.A.1.103 - - ABC_tran,Wzt_C SRD1_k127_5864413_2 1096546.WYO_4385 5.395e-05 56.0 COG2244@1|root,COG2244@2|Bacteria 2|Bacteria S polysaccharide biosynthetic process - - - - - - - - - - - - Polysacc_synt,Polysacc_synt_3,Polysacc_synt_C SRD1_k127_5864413_0 1038869.AXAN01000001_gene3833 7.479e-35 148.0 COG1215@1|root,COG1215@2|Bacteria,1QTZ1@1224|Proteobacteria,2VWJU@28216|Betaproteobacteria,1K0FJ@119060|Burkholderiaceae 28216|Betaproteobacteria M Pfam Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 SRD1_k127_5864413_1 1128421.JAGA01000002_gene751 2.749e-20 96.0 COG1216@1|root,COG1216@2|Bacteria,2NP9Z@2323|unclassified Bacteria 2|Bacteria GM Glycosyltransferase like family 2 - - - ko:K07011 - - - - ko00000 - - - Glyco_tranf_2_3,Glycos_transf_2 SRD1_k127_5865134_0 945713.IALB_1702 1.035e-164 530.0 COG0617@1|root,COG0617@2|Bacteria 2|Bacteria J CTP:tRNA cytidylyltransferase activity cca - 2.7.7.19,2.7.7.72 ko:K00970,ko:K00974 ko03013,ko03018,map03013,map03018 - R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016,ko03019 - - - HD,PolyA_pol,PolyA_pol_RNAbd SRD1_k127_5865134_1 945713.IALB_1051 6.985e-74 253.0 COG0673@1|root,COG0673@2|Bacteria 2|Bacteria S inositol 2-dehydrogenase activity gnnA - - ko:K09949 - - - - ko00000 - - iAF987.Gmet_2352 GFO_IDH_MocA SRD1_k127_5872562_1 357808.RoseRS_1474 2.413e-09 61.0 COG0758@1|root,COG0758@2|Bacteria 2|Bacteria LU DNA mediated transformation dprA - - ko:K04096 - - - - ko00000 - - - DNA_processg_A SRD1_k127_5872562_0 289376.THEYE_A1137 7.009e-110 378.0 COG1074@1|root,COG1074@2|Bacteria,3J16M@40117|Nitrospirae 40117|Nitrospirae L PD-(D/E)XK nuclease superfamily - - - - - - - - - - - - PDDEXK_1,UvrD-helicase,UvrD_C SRD1_k127_5880939_2 945713.IALB_1257 2.391e-89 308.0 COG4447@1|root,COG4447@2|Bacteria 2|Bacteria S cellulose binding - - - - - - - - - - - - BNR,PSII_BNR,Sortilin-Vps10 SRD1_k127_5880939_4 945713.IALB_1258 7.913e-63 228.0 COG2067@1|root,COG2067@2|Bacteria 2|Bacteria I long-chain fatty acid transporting porin activity - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - MtrB_PioB SRD1_k127_5880939_5 945713.IALB_1259 2.742e-39 158.0 COG2067@1|root,COG2067@2|Bacteria 2|Bacteria I long-chain fatty acid transporting porin activity - - - - - - - - - - - - - SRD1_k127_5880939_6 945713.IALB_2100 2.744e-39 152.0 COG0454@1|root,COG0456@2|Bacteria 2|Bacteria K acetyltransferase - - 2.3.1.57 ko:K22441 - - - - ko00000,ko01000 - - - Acetyltransf_1 SRD1_k127_5880939_1 452637.Oter_2529 8.346e-111 367.0 COG3940@1|root,COG3940@2|Bacteria,46V96@74201|Verrucomicrobia 74201|Verrucomicrobia G Glycosyl hydrolases family 43 - - - - - - - - - - - - Glyco_hydro_43 SRD1_k127_5880939_0 1191523.MROS_2492 5.894e-150 482.0 COG0859@1|root,COG0859@2|Bacteria 2|Bacteria M ADP-heptose-lipopolysaccharide heptosyltransferase activity - - - ko:K02843 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT9 - Glyco_transf_9 SRD1_k127_5880939_3 1191523.MROS_2494 1.002e-76 272.0 COG0859@1|root,COG0859@2|Bacteria 2|Bacteria M ADP-heptose-lipopolysaccharide heptosyltransferase activity - - - - - - - - - - - - Glyco_transf_9 SRD1_k127_5880939_7 321327.CYA_0846 1.973e-28 117.0 COG0177@1|root,COG0177@2|Bacteria,1GRH4@1117|Cyanobacteria,1H188@1129|Synechococcus 1117|Cyanobacteria L Base excision DNA repair protein, HhH-GPD family - - 4.2.99.18 ko:K10773 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - HhH-GPD SRD1_k127_5883160_1 1121094.KB894662_gene1023 3.488e-71 255.0 COG3408@1|root,COG3408@2|Bacteria,4NF09@976|Bacteroidetes,2FQZM@200643|Bacteroidia,4AMWC@815|Bacteroidaceae 976|Bacteroidetes G Amylo-alpha-1,6-glucosidase - - - - - - - - - - - - GDE_C,GDE_N SRD1_k127_5883160_0 880073.Calab_1017 2.032e-80 287.0 COG3408@1|root,COG4945@1|root,COG3408@2|Bacteria,COG4945@2|Bacteria 2|Bacteria G C-terminal binding-module, SLH-like, of glucodextranase VVA0055 - 3.2.1.3,3.2.1.41 ko:K01178,ko:K01200 ko00500,ko01100,ko01110,map00500,map01100,map01110 - R01790,R01791,R02111,R06199 - ko00000,ko00001,ko01000 - CBM48,GH13,GH15 - Alpha-amylase,Cu_amine_oxidN1,GDE_C,GDE_N,Glucodextran_B,Glucodextran_C,Glucodextran_N,Glyco_hydro_15,Glyco_hydro_49,Glyco_hydro_49N SRD1_k127_5883160_2 926549.KI421517_gene3819 1.916e-29 122.0 COG1028@1|root,COG1028@2|Bacteria,4NKY7@976|Bacteroidetes,47MF4@768503|Cytophagia 976|Bacteroidetes IQ KR domain - - 1.1.1.206 ko:K08081 ko00960,ko01100,ko01110,map00960,map01100,map01110 - R02832 RC00144 ko00000,ko00001,ko01000 - - - adh_short_C2 SRD1_k127_5908064_0 880073.Calab_1570 1.036e-58 220.0 COG0860@1|root,COG0860@2|Bacteria 2|Bacteria M N-Acetylmuramoyl-L-alanine amidase sap GO:0003674,GO:0005198,GO:0005199,GO:0005575,GO:0005623,GO:0008150,GO:0009273,GO:0009987,GO:0030115,GO:0030312,GO:0042546,GO:0044085,GO:0044464,GO:0071554,GO:0071840,GO:0071944 3.2.1.1,3.5.1.28 ko:K01176,ko:K01448 ko00500,ko01100,ko01503,ko04973,map00500,map01100,map01503,map04973 M00727 R02108,R02112,R04112,R11262 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - GH13 - Amidase_3,Big_2,Big_5,LysM,Peptidase_M23,SLH SRD1_k127_5908064_1 880073.Calab_1569 3.738e-45 175.0 COG0823@1|root,COG0823@2|Bacteria 2|Bacteria U Involved in the tonB-independent uptake of proteins - - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - Cu_amine_oxidN1,PD40,eIF2A SRD1_k127_5950690_3 864069.MicloDRAFT_00025890 1.486e-36 144.0 COG1215@1|root,COG1215@2|Bacteria,1NDPE@1224|Proteobacteria,2TSCT@28211|Alphaproteobacteria,1JUA4@119045|Methylobacteriaceae 28211|Alphaproteobacteria M PFAM Glycosyl transferase family 2 exoA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K16557 - - - - ko00000,ko01000,ko01003 - GT2 - Glycos_transf_2 SRD1_k127_5950690_1 530564.Psta_1439 5.317e-78 280.0 COG1232@1|root,COG1232@2|Bacteria,2IX1A@203682|Planctomycetes 203682|Planctomycetes H Flavin containing amine oxidoreductase - - - - - - - - - - - - Amino_oxidase SRD1_k127_5950690_0 926550.CLDAP_40290 2.893e-144 467.0 COG0399@1|root,COG0399@2|Bacteria,2G7XI@200795|Chloroflexi 200795|Chloroflexi E DegT/DnrJ/EryC1/StrS aminotransferase family - - - - - - - - - - - - DegT_DnrJ_EryC1 SRD1_k127_5950690_2 111780.Sta7437_4159 3.223e-43 168.0 COG1086@1|root,COG2200@1|root,COG1086@2|Bacteria,COG2200@2|Bacteria,1G18C@1117|Cyanobacteria,3VI4Z@52604|Pleurocapsales 1117|Cyanobacteria GM PFAM polysaccharide biosynthesis protein - - - - - - - - - - - - CoA_binding_3,EAL,Polysacc_synt_2 SRD1_k127_595762_1 880073.Calab_0781 3.416e-44 166.0 COG1595@1|root,COG1595@2|Bacteria,2NR5T@2323|unclassified Bacteria 2|Bacteria K TIGRFAM RNA polymerase sigma factor, sigma-70 family sigG - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 SRD1_k127_595762_0 518766.Rmar_2629 5.197e-54 201.0 COG1466@1|root,COG1466@2|Bacteria,4NEIB@976|Bacteroidetes,1FIXI@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes L DNA polymerase III, delta subunit holA - 2.7.7.7 ko:K02340 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta SRD1_k127_595762_2 945713.IALB_0654 2.529e-41 163.0 COG0652@1|root,COG0652@2|Bacteria 2|Bacteria O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides ppiB GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:0140096,GO:1901564 5.2.1.8 ko:K01802,ko:K03767,ko:K03768 ko01503,ko04217,map01503,map04217 - - - ko00000,ko00001,ko01000,ko03110,ko04147 - - - Hydrolase_3,Pro_isomerase SRD1_k127_5965556_0 1191523.MROS_0090 1.725e-167 537.0 COG1070@1|root,COG1070@2|Bacteria 2|Bacteria G xylulokinase activity rhaB GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005975,GO:0005996,GO:0006793,GO:0006796,GO:0008144,GO:0008150,GO:0008152,GO:0008993,GO:0009056,GO:0009987,GO:0016052,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0019200,GO:0019299,GO:0019301,GO:0019318,GO:0019320,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0046365,GO:0046835,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901575 2.7.1.17,2.7.1.5 ko:K00848,ko:K00854 ko00040,ko00051,ko01100,ko01120,map00040,map00051,map01100,map01120 M00014 R01639,R01902,R03014 RC00002,RC00017,RC00538 ko00000,ko00001,ko00002,ko01000 - - iEcE24377_1341.EcE24377A_4435 FGGY_C,FGGY_N SRD1_k127_5965556_1 485915.Dret_0454 1.141e-165 536.0 COG1271@1|root,COG2010@1|root,COG1271@2|Bacteria,COG2010@2|Bacteria,1NTJT@1224|Proteobacteria,42NK8@68525|delta/epsilon subdivisions,2WIM0@28221|Deltaproteobacteria,2M8SV@213115|Desulfovibrionales 28221|Deltaproteobacteria C PFAM Cytochrome c, class I - - - - - - - - - - - - Cyt_bd_oxida_I,Cytochrome_CBB3 SRD1_k127_5997470_3 880072.Desac_2171 1.656e-07 58.0 COG0417@1|root,COG0417@2|Bacteria 2|Bacteria L DNA replication proofreading polB - 2.7.7.7 ko:K02336,ko:K06877 - - - - ko00000,ko01000,ko03400 - - - CarbopepD_reg_2,DNA_pol_B,DNA_pol_B_exo1,RNase_H_2 SRD1_k127_5997470_1 509635.N824_07835 1.662e-34 145.0 2B9NZ@1|root,3231D@2|Bacteria,4NR0T@976|Bacteroidetes,1IUNH@117747|Sphingobacteriia 976|Bacteroidetes S Protein of unknown function (DUF1579) - - - - - - - - - - - - DUF1579 SRD1_k127_5997470_0 1047013.AQSP01000134_gene1374 3.893e-55 213.0 COG1277@1|root,COG1277@2|Bacteria 2|Bacteria - - - - - ko:K01992,ko:K16919 ko02010,map02010 M00254,M00584 - - ko00000,ko00001,ko00002,ko02000 3.A.1 - - ABC2_membrane_2,ABC2_membrane_4,ABC_transp_aux SRD1_k127_5997470_2 1047013.AQSP01000134_gene1374 1.489e-20 101.0 COG1277@1|root,COG1277@2|Bacteria 2|Bacteria - - - - - ko:K01992,ko:K16919 ko02010,map02010 M00254,M00584 - - ko00000,ko00001,ko00002,ko02000 3.A.1 - - ABC2_membrane_2,ABC2_membrane_4,ABC_transp_aux SRD1_k127_5998067_0 1303518.CCALI_00702 7.437e-84 286.0 COG5285@1|root,COG5285@2|Bacteria 2|Bacteria Q dioxygenase activity - - - - - - - - - - - - PhyH SRD1_k127_5998067_1 118168.MC7420_1817 2.785e-38 160.0 COG0784@1|root,COG3829@1|root,COG4191@1|root,COG4251@1|root,COG0784@2|Bacteria,COG3829@2|Bacteria,COG4191@2|Bacteria,COG4251@2|Bacteria,1GPYK@1117|Cyanobacteria,1HHZI@1150|Oscillatoriales 1117|Cyanobacteria T COG0642 Signal transduction histidine kinase - - - - - - - - - - - - GAF,HATPase_c,HisKA,PAS_3,PAS_9,Response_reg SRD1_k127_5998067_2 765911.Thivi_0288 4.432e-35 136.0 COG4251@1|root,COG4251@2|Bacteria,1N44A@1224|Proteobacteria,1SECK@1236|Gammaproteobacteria,1X14T@135613|Chromatiales 135613|Chromatiales T KaiB - - - ko:K08481 - - - - ko00000 - - - KaiB SRD1_k127_5998067_3 504472.Slin_1883 1.719e-05 46.0 COG4251@1|root,COG4251@2|Bacteria,4NSP2@976|Bacteroidetes,47RIP@768503|Cytophagia 976|Bacteroidetes T KaiB - - - ko:K08481 - - - - ko00000 - - - KaiB SRD1_k127_6021199_2 945713.IALB_1382 1.034e-07 55.0 COG4856@1|root,COG4856@2|Bacteria 2|Bacteria O YbbR-like protein ybbR GO:0008150,GO:0031279,GO:0031281,GO:0043085,GO:0044093,GO:0045761,GO:0045762,GO:0050790,GO:0051339,GO:0051349,GO:0065007,GO:0065009 - - - - - - - - - - YbbR SRD1_k127_6021199_0 945713.IALB_2176 9.265e-86 291.0 COG0854@1|root,COG0854@2|Bacteria 2|Bacteria H Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate pdxJ GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 2.6.99.2 ko:K03474 ko00750,ko01100,map00750,map01100 M00124 R05838 RC01476 ko00000,ko00001,ko00002,ko01000 - - - PdxJ SRD1_k127_6021199_1 1163408.UU9_12233 1.246e-20 101.0 COG2152@1|root,COG2152@2|Bacteria 2|Bacteria G transferase activity, transferring glycosyl groups - - - - - - - - - - - - Glyco_hydro_130,Glyco_hydro_32N,Glyco_hydro_43 SRD1_k127_6024551_0 945713.IALB_1501 2.917e-262 821.0 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria 2|Bacteria C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin korA GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0030312,GO:0044464,GO:0050896,GO:0055114,GO:0071944 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR,POR_N SRD1_k127_6036819_1 713586.KB900536_gene627 1.975e-66 233.0 COG0346@1|root,COG0346@2|Bacteria,1RJF9@1224|Proteobacteria,1SAAC@1236|Gammaproteobacteria,1WZ56@135613|Chromatiales 135613|Chromatiales E Glyoxalase-like domain - - - - - - - - - - - - Glyoxalase SRD1_k127_6036819_2 504472.Slin_4884 5.855e-28 124.0 2CKSA@1|root,2ZC1U@2|Bacteria,4NMGH@976|Bacteroidetes,47P79@768503|Cytophagia 976|Bacteroidetes - - - - - - - - - - - - - - - SRD1_k127_6036819_0 1236902.ANAS01000007_gene3846 7.399e-70 244.0 COG0546@1|root,COG0546@2|Bacteria,2GIU8@201174|Actinobacteria,4EI12@85012|Streptosporangiales 201174|Actinobacteria S HAD-hyrolase-like - - 3.1.3.18 ko:K01091 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 - R01334 RC00017 ko00000,ko00001,ko01000 - - - HAD_2 SRD1_k127_6036819_4 313606.M23134_02638 3.198e-20 98.0 2EIBB@1|root,33C2R@2|Bacteria,4NYRT@976|Bacteroidetes,47SNM@768503|Cytophagia 976|Bacteroidetes - - - - - - - - - - - - - - - SRD1_k127_6036819_5 768710.DesyoDRAFT_1947 6.857e-07 53.0 2DPAF@1|root,33188@2|Bacteria,1TZCQ@1239|Firmicutes,24VKM@186801|Clostridia 186801|Clostridia S Domain of unknown function (DUF4177) - - - - - - - - - - - - DUF4177 SRD1_k127_6036819_3 194439.CT0485 5.691e-24 102.0 2C530@1|root,2ZRHX@2|Bacteria 2|Bacteria S Domain of unknown function (DUF4177) - - - - - - - - - - - - DUF4177 SRD1_k127_6043107_4 880073.Calab_1714 3.026e-50 185.0 COG2866@1|root,COG2866@2|Bacteria,2NQT6@2323|unclassified Bacteria 2|Bacteria E Zn_pept - - - - - - - - - - - - Peptidase_M14 SRD1_k127_6043107_1 1191523.MROS_0714 1.536e-87 303.0 COG0438@1|root,COG0438@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups pimB_1 - - ko:K00754 - - - - ko00000,ko01000 - GT4 - Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1 SRD1_k127_6043107_0 469383.Cwoe_1088 1.74e-198 627.0 COG0372@1|root,COG0372@2|Bacteria,2GJ7E@201174|Actinobacteria,4CPID@84995|Rubrobacteria 84995|Rubrobacteria C Belongs to the citrate synthase family - - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt SRD1_k127_6043107_3 706587.Desti_5099 3.488e-53 199.0 COG0697@1|root,COG0697@2|Bacteria,1MUQ7@1224|Proteobacteria,42R74@68525|delta/epsilon subdivisions,2WMRT@28221|Deltaproteobacteria,2MRGD@213462|Syntrophobacterales 28221|Deltaproteobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA SRD1_k127_6043107_2 309801.trd_0014 1.957e-65 233.0 COG0566@1|root,COG0566@2|Bacteria,2GA03@200795|Chloroflexi,27Y5B@189775|Thermomicrobia 189775|Thermomicrobia J Catalyzes the 2'-O methylation of guanosine at position 18 in tRNA trmH - 2.1.1.34 ko:K00556 - - - - ko00000,ko01000,ko03016 - - - SpoU_methylase SRD1_k127_6055830_8 426716.JOAJ01000009_gene5889 1.47e-11 70.0 COG5512@1|root,COG5512@2|Bacteria,2GNQ4@201174|Actinobacteria,4FUXM@85025|Nocardiaceae 201174|Actinobacteria S Belongs to the UPF0232 family - - - - - - - - - - - - DUF721 SRD1_k127_6055830_1 1191523.MROS_1039 3.255e-289 902.0 COG0187@1|root,COG0187@2|Bacteria 2|Bacteria L DNA topoisomerase II activity gyrB GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006351,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009295,GO:0009330,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0032991,GO:0034335,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097367,GO:0097659,GO:0140097,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim SRD1_k127_6055830_0 945713.IALB_0006 0.0 1176.0 COG0188@1|root,COG0188@2|Bacteria 2|Bacteria L DNA topoisomerase II activity gyrA - 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV SRD1_k127_6055830_7 530564.Psta_0723 6.637e-14 79.0 2EJ52@1|root,33CW9@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - SRD1_k127_6055830_4 309807.SRU_1400 2.235e-113 392.0 COG2304@1|root,COG2304@2|Bacteria,4NER3@976|Bacteroidetes,1FIZK@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S von Willebrand factor (vWF) type A domain - - - - - - - - - - - - - SRD1_k127_6055830_2 945713.IALB_0465 3.381e-143 462.0 COG0714@1|root,COG0714@2|Bacteria 2|Bacteria KLT Associated with various cellular activities moxR - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 SRD1_k127_6055830_3 945713.IALB_0464 2.765e-120 400.0 COG0760@1|root,COG0760@2|Bacteria 2|Bacteria O peptidyl-prolyl cis-trans isomerase activity surA - 5.2.1.8 ko:K03771 - - - - ko00000,ko01000,ko03110 - - - Rotamase,SurA_N_3 SRD1_k127_6055830_6 518766.Rmar_1287 2.238e-17 93.0 COG0760@1|root,COG0760@2|Bacteria,4PEMF@976|Bacteroidetes,1FJAP@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes O PPIC-type PPIASE domain - - - - - - - - - - - - Rotamase_2 SRD1_k127_6055830_5 1519464.HY22_03695 1.993e-87 316.0 COG0760@1|root,COG0760@2|Bacteria,1FEUV@1090|Chlorobi 1090|Chlorobi O PPIC-type PPIASE domain - - 5.2.1.8 ko:K03771 - - - - ko00000,ko01000,ko03110 - - - - SRD1_k127_6059852_0 1267535.KB906767_gene5352 6.045e-280 873.0 COG0841@1|root,COG0841@2|Bacteria,3Y3F4@57723|Acidobacteria,2JIHS@204432|Acidobacteriia 204432|Acidobacteriia V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran SRD1_k127_6059852_1 1267535.KB906767_gene5351 3.652e-124 409.0 COG0845@1|root,COG0845@2|Bacteria,3Y3C9@57723|Acidobacteria,2JIN9@204432|Acidobacteriia 204432|Acidobacteriia M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_D23 SRD1_k127_6085654_0 1191523.MROS_0369 2.608e-115 379.0 COG1086@1|root,COG1086@2|Bacteria 2|Bacteria GM Polysaccharide biosynthesis protein - - 2.7.8.33,2.7.8.35 ko:K02851 - - R08856 RC00002 ko00000,ko01000,ko01003,ko01005 - - - Bac_transf,CoA_binding_3,Glycos_transf_4,HTH_45,LicD SRD1_k127_6085654_1 1191523.MROS_0628 2.151e-16 82.0 COG0790@1|root,COG0790@2|Bacteria 2|Bacteria S beta-lactamase activity - - - ko:K07126 - - - - ko00000 - - - Sel1,WG_beta_rep SRD1_k127_6090238_4 755178.Cyan10605_0680 5.85e-14 72.0 COG0463@1|root,COG0463@2|Bacteria,1G03Y@1117|Cyanobacteria 1117|Cyanobacteria M PFAM Glycosyl transferase family 2 - - - ko:K20534 - - - - ko00000,ko01000,ko01005,ko02000 4.D.2.1.9 GT2 - Glycos_transf_2 SRD1_k127_6090238_3 1499967.BAYZ01000014_gene6406 1.414e-47 179.0 COG0500@1|root,COG2226@2|Bacteria 2|Bacteria Q methyltransferase - - 2.1.1.95 ko:K05928 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00112 R07236,R07504,R10491,R10492 RC00003,RC01662 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_11,Methyltransf_23,Methyltransf_25 SRD1_k127_6090238_1 290397.Adeh_4297 3.986e-88 298.0 COG1208@1|root,COG1208@2|Bacteria,1MUYJ@1224|Proteobacteria,42MCW@68525|delta/epsilon subdivisions,2WIYK@28221|Deltaproteobacteria,2YZY8@29|Myxococcales 28221|Deltaproteobacteria JM Nucleotidyl transferase ddhA - 2.7.7.33 ko:K00978 ko00500,ko00520,ko01100,map00500,map00520,map01100 - R00956 RC00002 ko00000,ko00001,ko01000 - - - NTP_transferase SRD1_k127_6090238_0 517418.Ctha_0432 2.072e-113 377.0 COG0438@1|root,COG0438@2|Bacteria,1FDVR@1090|Chlorobi 1090|Chlorobi M PFAM glycosyl transferase group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 SRD1_k127_6090238_2 324925.Ppha_0256 1.845e-63 227.0 COG1216@1|root,COG1216@2|Bacteria,1FEN2@1090|Chlorobi 1090|Chlorobi M PFAM glycosyl transferase family 2 - - - ko:K07011 - - - - ko00000 - - - Glyco_tranf_2_3,Glycos_transf_2 SRD1_k127_6090238_5 1237149.C900_02527 0.0001315 52.0 COG2244@1|root,COG2244@2|Bacteria,4NINR@976|Bacteroidetes,47K6C@768503|Cytophagia 976|Bacteroidetes S Polysaccharide biosynthesis protein - - - - - - - - - - - - Polysacc_synt_3,Polysacc_synt_C SRD1_k127_6118863_2 742725.HMPREF9450_00181 0.0006895 47.0 COG0591@1|root,COG0591@2|Bacteria,4NEN8@976|Bacteroidetes,2FPDT@200643|Bacteroidia 976|Bacteroidetes E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - ko:K03307 - - - - ko00000 2.A.21 - - Kelch_1,Kelch_5,SSF SRD1_k127_6118863_0 595460.RRSWK_06077 5.314e-120 390.0 COG5426@1|root,COG5426@2|Bacteria,2J31F@203682|Planctomycetes 203682|Planctomycetes S Putative glutamine amidotransferase - - - - - - - - - - - - GATase1_like SRD1_k127_6118863_1 1168034.FH5T_07600 2.557e-84 287.0 COG3533@1|root,COG3533@2|Bacteria,4NFW3@976|Bacteroidetes,2FM1I@200643|Bacteroidia 976|Bacteroidetes S cog cog3533 - - - ko:K09955 - - - - ko00000 - - - F5_F8_type_C,Glyco_hydro_127 SRD1_k127_6123389_1 1519464.HY22_00560 3.87e-14 87.0 COG3292@1|root,COG4447@1|root,COG3292@2|Bacteria,COG4447@2|Bacteria 2|Bacteria S cellulose binding - - - - - - - - - - - - BNR,Reprolysin_5 SRD1_k127_6123389_0 1150600.ADIARSV_0400 2.835e-111 378.0 COG1629@1|root,COG4771@2|Bacteria,4NF66@976|Bacteroidetes,1IP8M@117747|Sphingobacteriia 976|Bacteroidetes P PFAM TonB-dependent Receptor Plug - - - - - - - - - - - - CarboxypepD_reg,Plug,TonB_dep_Rec SRD1_k127_6143875_1 518766.Rmar_0352 2.995e-49 180.0 COG1609@1|root,COG1609@2|Bacteria 2|Bacteria K purine nucleotide biosynthetic process - - - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_3 SRD1_k127_6143875_0 448385.sce8790 7.009e-80 277.0 COG0492@1|root,COG0492@2|Bacteria,1MVWS@1224|Proteobacteria,42YY5@68525|delta/epsilon subdivisions,2WPYC@28221|Deltaproteobacteria,2YUGH@29|Myxococcales 28221|Deltaproteobacteria C Pyridine nucleotide-disulphide oxidoreductase - - - - - - - - - - - - Pyr_redox_2 SRD1_k127_6143875_2 1124780.ANNU01000042_gene612 3.985e-14 79.0 COG0484@1|root,COG0484@2|Bacteria,4NE4X@976|Bacteroidetes,47JWI@768503|Cytophagia 976|Bacteroidetes O DnaJ molecular chaperone homology domain dnaJ2 - - ko:K03686,ko:K05516 - - - - ko00000,ko03029,ko03036,ko03110 - - - DnaJ,DnaJ_C SRD1_k127_6145319_1 313606.M23134_01805 1.782e-12 75.0 COG3225@1|root,COG3225@2|Bacteria,4NF62@976|Bacteroidetes,47UYK@768503|Cytophagia 976|Bacteroidetes N transport system involved in gliding motility, auxiliary component - - - - - - - - - - - - ABC_transp_aux SRD1_k127_6145319_2 518766.Rmar_1767 3.537e-12 77.0 2DT74@1|root,33IZF@2|Bacteria 2|Bacteria S Domain of unknown function (DUF4340) - - - - - - - - - - - - DUF4340 SRD1_k127_6145319_0 497965.Cyan7822_3120 5.916e-101 342.0 COG2133@1|root,COG2133@2|Bacteria,1G2QD@1117|Cyanobacteria,3KFRR@43988|Cyanothece 1117|Cyanobacteria G Glucose / Sorbosone dehydrogenase - - - ko:K21430 - - - - ko00000,ko01000 - - - GSDH SRD1_k127_6151194_1 945713.IALB_2070 2.756e-67 247.0 COG2067@1|root,COG2067@2|Bacteria 2|Bacteria I long-chain fatty acid transporting porin activity - - - - - - - - - - - - TraF_2 SRD1_k127_6151194_0 1191523.MROS_1780 3.008e-124 415.0 COG2366@1|root,COG2366@2|Bacteria 2|Bacteria D antibiotic biosynthetic process acyII - 3.5.1.11,3.5.1.97 ko:K01434,ko:K07116 ko00311,ko01130,map00311,map01130 - R02170 RC00166,RC00328 ko00000,ko00001,ko01000,ko01002 - - - Penicil_amidase SRD1_k127_6157021_2 1047013.AQSP01000134_gene1374 1.146e-47 182.0 COG1277@1|root,COG1277@2|Bacteria 2|Bacteria - - - - - ko:K01992,ko:K16919 ko02010,map02010 M00254,M00584 - - ko00000,ko00001,ko00002,ko02000 3.A.1 - - ABC2_membrane_2,ABC2_membrane_4,ABC_transp_aux SRD1_k127_6157021_0 1047013.AQSP01000134_gene1373 1.904e-92 309.0 COG1131@1|root,COG1131@2|Bacteria,2NR18@2323|unclassified Bacteria 2|Bacteria V AAA domain, putative AbiEii toxin, Type IV TA system - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran SRD1_k127_6157021_1 1122931.AUAE01000013_gene2071 2.699e-65 237.0 COG1470@1|root,COG1470@2|Bacteria 2|Bacteria S cell adhesion involved in biofilm formation - - - - - - - - - - - - DUF4384,DUF4625,NPCBM_assoc,PEGA SRD1_k127_6169635_3 1382315.JPOI01000001_gene2675 7.732e-07 52.0 COG2084@1|root,COG2084@2|Bacteria,1TR4F@1239|Firmicutes,4H9MA@91061|Bacilli,1WF8D@129337|Geobacillus 91061|Bacilli I NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - 1.1.1.31 ko:K00020 ko00280,ko01100,map00280,map01100 - R05066 RC00099 ko00000,ko00001,ko01000 - - - NAD_binding_11,NAD_binding_2 SRD1_k127_6169635_0 1191523.MROS_0741 1.287e-42 164.0 COG1595@1|root,COG1595@2|Bacteria 2|Bacteria K DNA-templated transcription, initiation - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 SRD1_k127_6169635_4 518766.Rmar_0213 1.008e-05 57.0 29X1Z@1|root,30IQD@2|Bacteria,4P76S@976|Bacteroidetes 976|Bacteroidetes S Gas vesicle synthesis protein GvpL/GvpF - - - - - - - - - - - - GvpL_GvpF SRD1_k127_6169635_1 1337936.IJ00_07375 1.808e-15 78.0 2DNT7@1|root,32Z0Z@2|Bacteria,1G93V@1117|Cyanobacteria 1117|Cyanobacteria S Cysteine-rich CPXCG - - - - - - - - - - - - Cys_rich_CPXG SRD1_k127_6170464_0 1382359.JIAL01000001_gene568 1.088e-213 692.0 COG3250@1|root,COG3250@2|Bacteria,3Y8MH@57723|Acidobacteria,2JNGQ@204432|Acidobacteriia 204432|Acidobacteriia G beta-galactosidase activity - - - - - - - - - - - - - SRD1_k127_6170464_1 118161.KB235922_gene853 1.095e-11 79.0 COG2133@1|root,COG3210@1|root,COG3291@1|root,COG5306@1|root,COG2133@2|Bacteria,COG3210@2|Bacteria,COG3291@2|Bacteria,COG5306@2|Bacteria 2|Bacteria S metallopeptidase activity exbB2 - 3.2.1.14,3.4.14.5 ko:K01183,ko:K01278,ko:K03561,ko:K12287 ko00520,ko01100,ko04974,map00520,map01100,map04974 - R01206,R02334 RC00467 ko00000,ko00001,ko01000,ko01002,ko02000,ko02044,ko04090,ko04147 1.A.30.2.1 GH18 - CHRD,DUF2341,Laminin_G_3,MotA_ExbB,PKD SRD1_k127_6180080_0 497964.CfE428DRAFT_4597 1.643e-227 716.0 COG4108@1|root,COG4108@2|Bacteria,46SF9@74201|Verrucomicrobia 74201|Verrucomicrobia J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP prfC - - ko:K02837 - - - - ko00000,ko03012 - - - GTP_EFTU,GTP_EFTU_D2,RF3_C SRD1_k127_6180080_1 1123242.JH636435_gene2322 5.045e-199 629.0 COG0364@1|root,COG0364@2|Bacteria,2IYER@203682|Planctomycetes 203682|Planctomycetes G Glucose-6-phosphate dehydrogenase, NAD binding domain - - 1.1.1.363,1.1.1.49 ko:K00036 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230 M00004,M00006,M00008 R00835,R02736,R10907 RC00001,RC00066 ko00000,ko00001,ko00002,ko01000,ko04147 - - - G6PD_C,G6PD_N SRD1_k127_6180080_2 661478.OP10G_1466 1.312e-97 326.0 COG0546@1|root,COG0546@2|Bacteria 2|Bacteria S glycolate biosynthetic process - - 3.1.3.18 ko:K01091,ko:K05967,ko:K07025 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 - R01334 RC00017 ko00000,ko00001,ko01000 - - - HAD_2,NT5C SRD1_k127_6180080_3 485913.Krac_11704 5.418e-28 118.0 COG1985@1|root,COG1985@2|Bacteria,2G97Y@200795|Chloroflexi 200795|Chloroflexi H RibD C-terminal domain - - - - - - - - - - - - RibD_C SRD1_k127_6186469_8 1042376.AFPK01000071_gene720 5.806e-41 152.0 COG3118@1|root,COG3118@2|Bacteria,4NQNX@976|Bacteroidetes,1I3D1@117743|Flavobacteriia 976|Bacteroidetes O Belongs to the thioredoxin family - - - - - - - - - - - - Thioredoxin SRD1_k127_6186469_3 945713.IALB_2867 1.033e-98 336.0 COG1322@1|root,COG1322@2|Bacteria 2|Bacteria S DNA recombination rmuC - - ko:K09760 - - - - ko00000 - - - RmuC SRD1_k127_6186469_6 357804.Ping_2264 3.367e-58 209.0 COG3417@1|root,COG3417@2|Bacteria,1RA6V@1224|Proteobacteria,1S4SE@1236|Gammaproteobacteria,2QHZ3@267894|Psychromonadaceae 1236|Gammaproteobacteria M Peptidoglycan-synthase activator LpoB - - - ko:K07337 - - - - ko00000 - - - LpoB SRD1_k127_6186469_2 517418.Ctha_1249 2.157e-122 407.0 COG3014@1|root,COG3014@2|Bacteria,1FFNE@1090|Chlorobi 1090|Chlorobi S protein conserved in bacteria - - - ko:K09859 - - - - ko00000 - - - - SRD1_k127_6186469_0 1173021.ALWA01000035_gene3830 3.389e-286 896.0 COG0296@1|root,COG0296@2|Bacteria,1G1IW@1117|Cyanobacteria 1117|Cyanobacteria G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position glgB - 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 iJN678.glgB Alpha-amylase,Alpha-amylase_C,CBM_48 SRD1_k127_6186469_9 518766.Rmar_1602 6.286e-20 104.0 COG5012@1|root,COG5012@2|Bacteria 2|Bacteria T cobalamin binding - - - ko:K22491 - - - - ko00000,ko03000 - - - B12-binding,B12-binding_2,HTH_3 SRD1_k127_6186469_5 867903.ThesuDRAFT_01424 4.331e-77 271.0 COG1090@1|root,COG1090@2|Bacteria,1TRCE@1239|Firmicutes,24GWH@186801|Clostridia 186801|Clostridia S PFAM NAD dependent epimerase dehydratase family - - - ko:K07071 - - - - ko00000 - - - DUF1731,Epimerase SRD1_k127_6186469_1 1191523.MROS_0642 1.261e-246 778.0 COG1884@1|root,COG1884@2|Bacteria 2|Bacteria I Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly bhbA - 5.4.99.2 ko:K01848 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00375,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - - MM_CoA_mutase SRD1_k127_6186469_7 886379.AEWI01000013_gene2111 7.807e-57 205.0 COG0346@1|root,COG0346@2|Bacteria,4NNGG@976|Bacteroidetes,2FRZS@200643|Bacteroidia,3XJZG@558415|Marinilabiliaceae 976|Bacteroidetes E Glyoxalase-like domain mce - 5.1.99.1 ko:K05606 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00375,M00376,M00741 R02765,R09979 RC00780,RC02739 ko00000,ko00001,ko00002,ko01000 - - - Glyoxalase_4 SRD1_k127_6186469_4 945713.IALB_0653 6.362e-80 276.0 COG1968@1|root,COG1968@2|Bacteria 2|Bacteria V undecaprenyl-diphosphatase activity uppP GO:0006950,GO:0008150,GO:0050896,GO:0051409 3.6.1.27 ko:K06153 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - BacA SRD1_k127_6186469_10 402626.Rpic_1673 2.708e-13 79.0 COG2197@1|root,COG2197@2|Bacteria,1R9ZF@1224|Proteobacteria,2VUG4@28216|Betaproteobacteria,1K7MW@119060|Burkholderiaceae 28216|Betaproteobacteria K Transcriptional regulator - - - - - - - - - - - - GerE,Response_reg SRD1_k127_6187790_4 468059.AUHA01000002_gene74 8.145e-05 53.0 COG1404@1|root,COG1404@2|Bacteria,4NF1M@976|Bacteroidetes,1ITAS@117747|Sphingobacteriia 976|Bacteroidetes O Serine protease, subtilase family - - 3.4.21.66 ko:K08651 - - - - ko00000,ko01000,ko01002,ko03110 - - - Peptidase_S8 SRD1_k127_6187790_1 96561.Dole_1727 4.494e-62 221.0 COG0484@1|root,COG0705@1|root,COG0484@2|Bacteria,COG0705@2|Bacteria,1MYFP@1224|Proteobacteria,42P0V@68525|delta/epsilon subdivisions,2WJGR@28221|Deltaproteobacteria,2MI6P@213118|Desulfobacterales 28221|Deltaproteobacteria O Rhomboid family - - - ko:K07059 - - - - ko00000 - - - DnaJ_C,Rhomboid SRD1_k127_6187790_0 234267.Acid_4166 3.517e-139 456.0 COG0079@1|root,COG0079@2|Bacteria,3Y4H9@57723|Acidobacteria 57723|Acidobacteria E Aminotransferase class I and II - - 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 SRD1_k127_6187790_3 234267.Acid_4167 1.003e-40 153.0 COG3185@1|root,COG3185@2|Bacteria,3Y2ST@57723|Acidobacteria 57723|Acidobacteria E Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal - - 1.13.11.27 ko:K00457 ko00130,ko00350,ko00360,ko01100,map00130,map00350,map00360,map01100 M00044 R01372,R02521 RC00505,RC00738 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Glyoxalase SRD1_k127_619249_2 1237149.C900_05550 7.277e-51 188.0 COG1506@1|root,COG1506@2|Bacteria,4NETS@976|Bacteroidetes,47KF8@768503|Cytophagia 976|Bacteroidetes EU Dipeptidyl peptidase IV (DPP IV) N-terminal region - - 3.4.14.5 ko:K01278 ko04974,map04974 - - - ko00000,ko00001,ko01000,ko01002,ko04090,ko04147 - - - DPPIV_N,Peptidase_S9 SRD1_k127_619249_0 1123248.KB893338_gene2306 3.828e-199 647.0 COG0577@1|root,COG0577@2|Bacteria,4NDUK@976|Bacteroidetes,1IRGG@117747|Sphingobacteriia 976|Bacteroidetes V MacB-like periplasmic core domain - - - - - - - - - - - - FtsX,MacB_PCD SRD1_k127_619249_1 1047013.AQSP01000142_gene184 5.047e-84 295.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD SRD1_k127_6199437_1 493475.GARC_5358 1.663e-27 123.0 COG3345@1|root,COG3345@2|Bacteria,1MW78@1224|Proteobacteria,1RRKC@1236|Gammaproteobacteria 1236|Gammaproteobacteria G enterotoxin ast - - - - - - - - - - - - SRD1_k127_6199437_0 234267.Acid_6591 3.125e-301 933.0 COG0591@1|root,COG0591@2|Bacteria,3Y4WN@57723|Acidobacteria 57723|Acidobacteria E Sodium:solute symporter family - - - - - - - - - - - - SSF SRD1_k127_6199437_2 1379270.AUXF01000001_gene2135 3.225e-11 67.0 COG3871@1|root,COG3871@2|Bacteria 2|Bacteria S Pyridoxamine 5'-phosphate oxidase ydaG - 1.4.3.5 ko:K00275 ko00750,ko01100,ko01120,map00750,map01100,map01120 M00124 R00277,R00278,R01710,R01711 RC00048,RC00116 ko00000,ko00001,ko00002,ko01000 - - - Putative_PNPOx,Pyrid_ox_like SRD1_k127_6207775_2 215803.DB30_2841 1.401e-09 63.0 COG0477@1|root,COG2814@2|Bacteria,1QTX0@1224|Proteobacteria,42PT2@68525|delta/epsilon subdivisions,2WJ6Q@28221|Deltaproteobacteria,2YWF8@29|Myxococcales 28221|Deltaproteobacteria EGP Transmembrane secretion effector - - - - - - - - - - - - MFS_3 SRD1_k127_6207775_0 1123277.KB893172_gene474 1.615e-141 467.0 COG5434@1|root,COG5434@2|Bacteria,4NFSC@976|Bacteroidetes,47Q1K@768503|Cytophagia 976|Bacteroidetes M Pectate lyase superfamily protein - - - - - - - - - - - - Glyco_hydro_28,Pectate_lyase_3 SRD1_k127_6207775_1 1122621.ATZA01000005_gene595 5.251e-64 224.0 COG0363@1|root,COG0363@2|Bacteria,4NGGK@976|Bacteroidetes,1IRST@117747|Sphingobacteriia 976|Bacteroidetes G Glucosamine-6-phosphate - - 3.5.99.6 ko:K02564 ko00520,ko01100,map00520,map01100 - R00765 RC00163 ko00000,ko00001,ko01000 - - - Glucosamine_iso SRD1_k127_622277_5 1316936.K678_10691 5.857e-12 70.0 2C7CG@1|root,33AMC@2|Bacteria,1NQDB@1224|Proteobacteria,2UKNG@28211|Alphaproteobacteria,2JY58@204441|Rhodospirillales 204441|Rhodospirillales - - - - - - - - - - - - - - - SRD1_k127_622277_3 111781.Lepto7376_2455 6.587e-19 90.0 COG2197@1|root,COG2197@2|Bacteria,1GHEX@1117|Cyanobacteria 1117|Cyanobacteria K COGs COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain - - - - - - - - - - - - GerE,Response_reg SRD1_k127_622277_0 1166018.FAES_4252 2.566e-119 409.0 COG0358@1|root,COG0358@2|Bacteria,4NENT@976|Bacteroidetes,47K9B@768503|Cytophagia 976|Bacteroidetes L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG - - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2 SRD1_k127_622277_2 1379698.RBG1_1C00001G1038 9.926e-63 229.0 COG0859@1|root,COG0859@2|Bacteria,2NPXQ@2323|unclassified Bacteria 2|Bacteria M Glycosyltransferase family 9 (heptosyltransferase) - - - ko:K02843 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT9 - Glyco_transf_9 SRD1_k127_622277_1 945713.IALB_0619 6.167e-87 304.0 COG3170@1|root,COG3170@2|Bacteria 2|Bacteria NU translation initiation factor activity - - - - - - - - - - - - DUF3108 SRD1_k127_622277_4 1047013.AQSP01000128_gene426 1.284e-17 86.0 COG1899@1|root,COG1899@2|Bacteria,2NP1S@2323|unclassified Bacteria 2|Bacteria O peptidyl-lysine modification to peptidyl-hypusine - - - - - - - - - - - - - SRD1_k127_6225092_1 382464.ABSI01000010_gene3491 9.978e-22 105.0 COG4447@1|root,COG4447@2|Bacteria,46VN1@74201|Verrucomicrobia 74201|Verrucomicrobia S cellulose binding - - - - - - - - - - - - - SRD1_k127_6225092_0 452637.Oter_2906 1.189e-105 359.0 2CC7E@1|root,32M7R@2|Bacteria,46UM2@74201|Verrucomicrobia,3K8H5@414999|Opitutae 414999|Opitutae - - - - - - - - - - - - - - - SRD1_k127_6228250_0 1121104.AQXH01000001_gene1459 2.145e-88 321.0 COG3292@1|root,COG4585@1|root,COG3292@2|Bacteria,COG4585@2|Bacteria,4NRVM@976|Bacteroidetes,1IQDC@117747|Sphingobacteriia 976|Bacteroidetes T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA_3,Reg_prop,Y_Y_Y SRD1_k127_6230873_0 864563.HMPREF9166_2087 0.0002052 55.0 COG2911@1|root,COG2911@2|Bacteria,1TQZZ@1239|Firmicutes,4H2F1@909932|Negativicutes 909932|Negativicutes S TamB, inner membrane protein subunit of TAM complex - - - ko:K09800 - - - - ko00000,ko02000 - - - AsmA_2,TamB SRD1_k127_6230873_1 281687.CJA03235 0.0002089 49.0 COG0457@1|root,KOG1124@2759|Eukaryota,38CY4@33154|Opisthokonta,3BDZ9@33208|Metazoa,3CW1H@33213|Bilateria,40FNS@6231|Nematoda,1M3F1@119089|Chromadorea,4107D@6236|Rhabditida 33208|Metazoa S Domain of unknown function (DUF1736) TMTC2 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005789,GO:0008150,GO:0012505,GO:0016020,GO:0031984,GO:0042175,GO:0042592,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0048878,GO:0050801,GO:0055065,GO:0055074,GO:0055080,GO:0065007,GO:0065008,GO:0072507,GO:0098771,GO:0098827 - - - - - - - - - - DUF1736,TPR_1,TPR_16,TPR_2,TPR_8 SRD1_k127_6239323_0 247490.KSU1_B0016 1.017e-134 437.0 COG0158@1|root,COG0158@2|Bacteria,2IWT3@203682|Planctomycetes 203682|Planctomycetes G D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 fbp - 3.1.3.11 ko:K03841 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko04152,ko04910,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map04152,map04910 M00003,M00165,M00167,M00344 R00762,R04780 RC00017 ko00000,ko00001,ko00002,ko01000,ko04147 - - - FBPase SRD1_k127_6239323_3 945713.IALB_2065 4.759e-93 315.0 COG0189@1|root,COG0189@2|Bacteria 2|Bacteria HJ Glutathione synthase Ribosomal protein S6 modification enzyme (Glutaminyl transferase) - - 6.3.2.43 ko:K05827,ko:K05844 ko00300,ko01100,ko01210,ko01230,map00300,map01100,map01210,map01230 M00031 R09775 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000,ko03009 - - - RimK SRD1_k127_6239323_2 1191523.MROS_2055 3.435e-109 375.0 COG0457@1|root,COG0457@2|Bacteria 1191523.MROS_2055|- S peptidyl-tyrosine sulfation - - - - - - - - - - - - - SRD1_k127_6239323_4 945713.IALB_2062 1.525e-62 230.0 COG4942@1|root,COG4942@2|Bacteria 2|Bacteria D peptidase envC - - - - - - - - - - - Peptidase_M23 SRD1_k127_6239323_1 1191523.MROS_1604 8.493e-112 393.0 COG3829@1|root,COG4252@1|root,COG3829@2|Bacteria,COG4252@2|Bacteria 2|Bacteria T Chase2 domain - - - - - - - - - - - - CHASE2,DUF928,HTH_8,Sigma54_activat SRD1_k127_6239323_5 1191523.MROS_1607 9.523e-60 230.0 COG1305@1|root,COG1305@2|Bacteria 2|Bacteria E Transglutaminase-like superfamily - - - - - - - - - - - - DUF3857,DUF3858,Transglut_core SRD1_k127_6242499_0 1379698.RBG1_1C00001G0518 1.226e-139 465.0 COG0515@1|root,COG0515@2|Bacteria,2NQNE@2323|unclassified Bacteria 2|Bacteria T Serine threonine protein kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PASTA,Pkinase,TPR_2,TPR_8 SRD1_k127_6258680_0 945713.IALB_1289 1.44e-129 424.0 COG0249@1|root,COG0249@2|Bacteria 2|Bacteria L mismatched DNA binding mutS GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V SRD1_k127_6258680_1 1519464.HY22_00560 1.991e-62 241.0 COG3292@1|root,COG4447@1|root,COG3292@2|Bacteria,COG4447@2|Bacteria 2|Bacteria S cellulose binding - - - - - - - - - - - - BNR,Reprolysin_5 SRD1_k127_6305772_2 518766.Rmar_1010 1.398e-65 238.0 COG0778@1|root,COG0778@2|Bacteria,4NQ04@976|Bacteroidetes 976|Bacteroidetes C Nitroreductase - - - - - - - - - - - - Nitroreductase SRD1_k127_6305772_1 1191523.MROS_2426 2.846e-150 499.0 COG0626@1|root,COG0626@2|Bacteria 2|Bacteria E cystathionine gamma-synthase activity megL - 4.4.1.1,4.4.1.11,4.4.1.8 ko:K01758,ko:K01760,ko:K01761 ko00260,ko00270,ko00450,ko01100,ko01110,ko01130,ko01230,map00260,map00270,map00450,map01100,map01110,map01130,map01230 M00017,M00338 R00654,R00782,R01001,R01286,R02408,R04770,R04930,R04941,R09366 RC00056,RC00069,RC00196,RC00348,RC00382,RC00488,RC00710,RC01209,RC01210,RC01245,RC02303 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Cys_Met_Meta_PP SRD1_k127_6305772_0 1379698.RBG1_1C00001G0700 1.18e-158 509.0 COG0427@1|root,COG0427@2|Bacteria,2NQDP@2323|unclassified Bacteria 2|Bacteria C Acetyl-CoA hydrolase/transferase N-terminal domain - - 3.1.2.1 ko:K01067 ko00620,map00620 - R00227 RC00004,RC00012 ko00000,ko00001,ko01000 - - - AcetylCoA_hyd_C,AcetylCoA_hydro SRD1_k127_631971_0 479434.Sthe_3260 1.001e-69 247.0 COG1194@1|root,COG1194@2|Bacteria,2G62P@200795|Chloroflexi,27XJQ@189775|Thermomicrobia 189775|Thermomicrobia L FES - - - ko:K03575 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - HhH-GPD SRD1_k127_631971_1 944481.JAFP01000001_gene495 1.788e-23 106.0 COG1059@1|root,COG1059@2|Bacteria,1NIK9@1224|Proteobacteria,42SB1@68525|delta/epsilon subdivisions,2WQ7E@28221|Deltaproteobacteria,2M743@213113|Desulfurellales 28221|Deltaproteobacteria L endonuclease III - - 4.2.99.18 ko:K03653 - - - - ko00000,ko01000 - - - HhH-GPD SRD1_k127_6326354_4 518766.Rmar_0338 2.449e-31 125.0 COG2967@1|root,COG2967@2|Bacteria,4NNRA@976|Bacteroidetes,1FJHH@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes P ApaG domain apaG - - ko:K06195 - - - - ko00000 - - - DUF525 SRD1_k127_6326354_3 868595.Desca_0490 5.437e-93 319.0 COG0787@1|root,COG0787@2|Bacteria,1TNYY@1239|Firmicutes,2480T@186801|Clostridia,260IY@186807|Peptococcaceae 186801|Clostridia M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids alr - 5.1.1.1 ko:K01775 ko00473,ko01100,ko01502,map00473,map01100,map01502 - R00401 RC00285 ko00000,ko00001,ko01000,ko01011 - - - Ala_racemase_C,Ala_racemase_N SRD1_k127_6326354_5 926569.ANT_31220 2.509e-16 86.0 COG3437@1|root,COG3437@2|Bacteria,2G6QF@200795|Chloroflexi 200795|Chloroflexi T metal-dependent phosphohydrolase, HD sub domain - - - ko:K07814 - - - - ko00000,ko02022 - - - HD,HD_5,Response_reg SRD1_k127_6326354_1 926569.ANT_16550 2.496e-141 456.0 COG0451@1|root,COG0451@2|Bacteria,2G8B1@200795|Chloroflexi 200795|Chloroflexi GM Polysaccharide biosynthesis protein - - - - - - - - - - - - Epimerase SRD1_k127_6326354_2 1166018.FAES_3521 1.058e-135 448.0 COG2234@1|root,COG2234@2|Bacteria,4NE66@976|Bacteroidetes,47MBT@768503|Cytophagia 976|Bacteroidetes S Peptidase family M28 - - - - - - - - - - - - PA,Peptidase_M28 SRD1_k127_6326354_0 1232683.ADIMK_0377 8.612e-148 479.0 COG0247@1|root,COG0277@1|root,COG0479@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,COG0479@2|Bacteria,1MU6Y@1224|Proteobacteria,1RM7Z@1236|Gammaproteobacteria,465SS@72275|Alteromonadaceae 1236|Gammaproteobacteria C COG0277 FAD FMN-containing dehydrogenases lldE - - ko:K18930 - - - - ko00000 - - - CCG,FAD-oxidase_C,FAD_binding_4,Fer4_7,Fer4_8 SRD1_k127_6336361_2 32057.KB217478_gene963 1.169e-50 187.0 COG0463@1|root,COG0463@2|Bacteria,1GEJY@1117|Cyanobacteria,1HTJE@1161|Nostocales 1117|Cyanobacteria M Glycosyl transferase family 2 - - 2.4.1.83 ko:K00721 ko00510,ko01100,map00510,map01100 - R01009 RC00005 ko00000,ko00001,ko01000,ko01003 - GT2 - Glycos_transf_2 SRD1_k127_6336361_0 118166.JH976537_gene12 7.384e-132 439.0 COG0399@1|root,COG0399@2|Bacteria,1G3H0@1117|Cyanobacteria,1H8TM@1150|Oscillatoriales 1117|Cyanobacteria M Cys/Met metabolism PLP-dependent enzyme - - - - - - - - - - - - DegT_DnrJ_EryC1 SRD1_k127_6336361_1 530564.Psta_1437 1.293e-90 310.0 COG0673@1|root,COG0673@2|Bacteria,2IXZN@203682|Planctomycetes 203682|Planctomycetes S Oxidoreductase family, C-terminal alpha/beta domain - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C SRD1_k127_6336361_3 1123508.JH636439_gene1507 1.07e-25 108.0 COG0110@1|root,COG0110@2|Bacteria,2IZ7A@203682|Planctomycetes 203682|Planctomycetes S Hexapeptide repeat of succinyl-transferase - - 2.3.1.201 ko:K13018 ko00520,map00520 - R10100 RC00004,RC00166 ko00000,ko00001,ko01000,ko01005 - - - GFO_IDH_MocA,Hexapep SRD1_k127_6337571_1 1124780.ANNU01000071_gene1021 2.436e-87 293.0 COG2271@1|root,COG2271@2|Bacteria,4NE7R@976|Bacteroidetes,47JBJ@768503|Cytophagia 976|Bacteroidetes G PFAM Major Facilitator Superfamily - - - ko:K08191 - - - - ko00000,ko02000 2.A.1.14.2 - - MFS_1,Sugar_tr SRD1_k127_6337571_0 717605.Theco_0518 5.415e-98 330.0 COG3717@1|root,COG3717@2|Bacteria,1TP4X@1239|Firmicutes,4HBJH@91061|Bacilli,26R50@186822|Paenibacillaceae 91061|Bacilli G Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate kduI - 5.3.1.17 ko:K01815 ko00040,map00040 - R04383 RC00541 ko00000,ko00001,ko01000 - - - KduI SRD1_k127_6337571_2 518766.Rmar_2469 3.836e-69 249.0 COG4677@1|root,COG4677@2|Bacteria,4NF12@976|Bacteroidetes 976|Bacteroidetes G Domain of unknown function (DUF4861) - - 3.1.1.11 ko:K01051 ko00040,ko01100,map00040,map01100 M00081 R02362 RC00460,RC00461 ko00000,ko00001,ko00002,ko01000 - - - DUF4861 SRD1_k127_6343380_1 63737.Npun_F5429 1.522e-45 177.0 COG1232@1|root,COG1232@2|Bacteria,1G465@1117|Cyanobacteria 1117|Cyanobacteria H Flavin containing amine oxidoreductase - - - - - - - - - - - - Amino_oxidase SRD1_k127_6343380_0 864069.MicloDRAFT_00025890 8.495e-105 351.0 COG1215@1|root,COG1215@2|Bacteria,1NDPE@1224|Proteobacteria,2TSCT@28211|Alphaproteobacteria,1JUA4@119045|Methylobacteriaceae 28211|Alphaproteobacteria M PFAM Glycosyl transferase family 2 exoA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K16557 - - - - ko00000,ko01000,ko01003 - GT2 - Glycos_transf_2 SRD1_k127_6343380_2 1123508.JH636439_gene1507 7.852e-39 150.0 COG0110@1|root,COG0110@2|Bacteria,2IZ7A@203682|Planctomycetes 203682|Planctomycetes S Hexapeptide repeat of succinyl-transferase - - 2.3.1.201 ko:K13018 ko00520,map00520 - R10100 RC00004,RC00166 ko00000,ko00001,ko01000,ko01005 - - - GFO_IDH_MocA,Hexapep SRD1_k127_6361360_0 1192124.LIG30_4691 1.193e-09 71.0 COG3408@1|root,COG3408@2|Bacteria,1MUYU@1224|Proteobacteria,2VIMW@28216|Betaproteobacteria,1K1QU@119060|Burkholderiaceae 28216|Betaproteobacteria G Amylo-alpha-1,6-glucosidase - - - - - - - - - - - - GDE_C,GDE_N_bis SRD1_k127_6363859_0 443144.GM21_1635 5.179e-107 359.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,43UCF@69541|Desulfuromonadales 28221|Deltaproteobacteria T response regulator pilR - - ko:K02667 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - HTH_8,Response_reg,Sigma54_activat SRD1_k127_6363859_1 316067.Geob_1632 4.104e-54 213.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MRH@68525|delta/epsilon subdivisions,2WM8D@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Histidine kinase HAMP - - 2.7.13.3 ko:K02482 - - - - ko00000,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,sCache_3_3 SRD1_k127_6363859_3 497964.CfE428DRAFT_4796 1.199e-10 74.0 28IVM@1|root,2Z8U0@2|Bacteria,46S57@74201|Verrucomicrobia 74201|Verrucomicrobia - - - - - - - - - - - - - - - SRD1_k127_6363859_2 1403819.BATR01000130_gene4660 2.98e-31 134.0 COG3794@1|root,COG3794@2|Bacteria,46SUG@74201|Verrucomicrobia 74201|Verrucomicrobia C Carboxypeptidase regulatory-like domain - - - - - - - - - - - - CarboxypepD_reg SRD1_k127_6363859_4 485917.Phep_2975 0.0002163 54.0 COG5373@1|root,COG5373@2|Bacteria,4NGKV@976|Bacteroidetes,1IP94@117747|Sphingobacteriia 976|Bacteroidetes S membrane protein (DUF2339) - - - - - - - - - - - - DUF2339 SRD1_k127_6390960_1 1206739.BAGJ01000259_gene5289 6.74e-115 379.0 COG0309@1|root,COG0309@2|Bacteria,2GJ7N@201174|Actinobacteria,4FTY3@85025|Nocardiaceae 201174|Actinobacteria O AIR synthase related protein, C-terminal domain hypE - - ko:K04655 - - - - ko00000 - - - AIRS,AIRS_C SRD1_k127_6390960_0 926569.ANT_17880 1.623e-157 502.0 COG0409@1|root,COG0409@2|Bacteria,2G5MS@200795|Chloroflexi 200795|Chloroflexi O hydrogenase expression formation protein HypD hypD - - ko:K04654 - - - - ko00000 - - - HypD SRD1_k127_6403058_0 945713.IALB_3001 1.03e-176 575.0 COG1220@1|root,COG1220@2|Bacteria 2|Bacteria O peptidase activity, acting on L-amino acid peptides hslU GO:0000166,GO:0000287,GO:0000502,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009266,GO:0009376,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019904,GO:0022607,GO:0030554,GO:0031597,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034214,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043335,GO:0043933,GO:0044085,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051259,GO:0065003,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1902494,GO:1904949,GO:1905368,GO:1905369 - ko:K03667 - - - - ko00000,ko03110 - - - AAA_2,ClpB_D2-small SRD1_k127_6403058_2 1191523.MROS_1123 4.248e-68 249.0 COG5405@1|root,COG5405@2|Bacteria 2|Bacteria O Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery hslV GO:0000166,GO:0000287,GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009266,GO:0009376,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016787,GO:0017076,GO:0019538,GO:0019904,GO:0022607,GO:0030163,GO:0030554,GO:0031597,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034214,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051259,GO:0051603,GO:0065003,GO:0070003,GO:0070011,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1904949,GO:1905368,GO:1905369 3.4.25.2 ko:K01419 - - - - ko00000,ko01000,ko01002 - - - Proteasome SRD1_k127_6403058_1 518766.Rmar_2654 6.224e-127 417.0 COG1508@1|root,COG1508@2|Bacteria,4NE5B@976|Bacteroidetes,1FIQH@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes K Sigma-54 factor, Activator interacting domain (AID) rpoN - - ko:K03092 ko02020,ko05111,map02020,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma54_AID,Sigma54_CBD,Sigma54_DBD SRD1_k127_6404014_1 945713.IALB_0123 7.264e-87 293.0 COG3279@1|root,COG3279@2|Bacteria 2|Bacteria KT phosphorelay signal transduction system lytT - - ko:K02477,ko:K07705,ko:K11641 ko02020,map02020 M00492,M00494 - - ko00000,ko00001,ko00002,ko02022 - - - LytTR,Response_reg SRD1_k127_6404014_2 945713.IALB_0122 5.126e-48 186.0 COG2972@1|root,COG2972@2|Bacteria 2|Bacteria T Histidine kinase - - - - - - - - - - - - His_kinase SRD1_k127_6404014_0 1047013.AQSP01000144_gene927 3.431e-155 499.0 COG3533@1|root,COG3533@2|Bacteria,2NNW0@2323|unclassified Bacteria 2|Bacteria S Beta-L-arabinofuranosidase, GH127 - - - ko:K09955 - - - - ko00000 - - - F5_F8_type_C,Glyco_hydro_127 SRD1_k127_6419294_6 880073.Calab_0198 4.849e-12 70.0 COG1593@1|root,COG1593@2|Bacteria,2NQTB@2323|unclassified Bacteria 2|Bacteria G Tripartite ATP-independent periplasmic transporter, DctM component - - - ko:K11690 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.56.1 - - DctM,DctQ SRD1_k127_6419294_5 880073.Calab_0199 6.576e-29 122.0 COG3090@1|root,COG3090@2|Bacteria 2|Bacteria G Trap-type c4-dicarboxylate transport system, small permease component - - - ko:K11689 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.56.1 - - DctQ SRD1_k127_6419294_1 880073.Calab_1130 1.335e-101 343.0 COG1638@1|root,COG1638@2|Bacteria,2NS33@2323|unclassified Bacteria 2|Bacteria G Bacterial extracellular solute-binding protein, family 7 - - - ko:K11688,ko:K21395 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.56.1 - - DctP SRD1_k127_6419294_4 880073.Calab_1131 8.546e-61 237.0 COG0457@1|root,COG0457@2|Bacteria 880073.Calab_1131|- S peptidyl-tyrosine sulfation - - - - - - - - - - - - - SRD1_k127_6419294_2 1131269.AQVV01000029_gene68 3.154e-81 291.0 COG0745@1|root,COG0745@2|Bacteria 1131269.AQVV01000029_gene68|- T phosphorelay signal transduction system - - - - - - - - - - - - - SRD1_k127_6419294_3 330214.NIDE0304 4.225e-81 288.0 COG5000@1|root,COG5002@1|root,COG5000@2|Bacteria,COG5002@2|Bacteria,3J11K@40117|Nitrospirae 40117|Nitrospirae T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - - - - - - - - - - HATPase_c,HisKA SRD1_k127_6419294_0 945713.IALB_0586 3.334e-125 419.0 COG0823@1|root,COG4775@1|root,COG0823@2|Bacteria,COG4775@2|Bacteria 2|Bacteria M membrane organization - - - ko:K03641,ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33,2.C.1.2 - - Bac_surface_Ag,PD40,POTRA,Peptidase_MA_2 SRD1_k127_6426577_1 1121920.AUAU01000004_gene857 1.004e-39 150.0 COG1804@1|root,COG1804@2|Bacteria,3Y4ZM@57723|Acidobacteria 57723|Acidobacteria C CoA-transferase family III - - - - - - - - - - - - CoA_transf_3 SRD1_k127_6426577_0 1121920.AUAU01000004_gene856 5.326e-200 629.0 COG0065@1|root,COG0065@2|Bacteria 2|Bacteria E 3-isopropylmalate dehydratase activity hacA - 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase SRD1_k127_6449295_5 1499967.BAYZ01000057_gene4710 1.321e-103 342.0 COG0501@1|root,COG0501@2|Bacteria,2NS4G@2323|unclassified Bacteria 2|Bacteria O Peptidase family M48 - - - - - - - - - - - - Peptidase_M48 SRD1_k127_6449295_7 1452718.JBOY01000023_gene331 2.092e-49 181.0 COG1970@1|root,COG1970@2|Bacteria,1RHG8@1224|Proteobacteria,1S3PD@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell mscL GO:0003674,GO:0005215,GO:0005216,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015075,GO:0015267,GO:0015318,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022838,GO:0022857,GO:0030104,GO:0031224,GO:0031226,GO:0032535,GO:0034220,GO:0042592,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0071944,GO:0090066 - ko:K03282 - - - - ko00000,ko02000 1.A.22.1 - - MscL SRD1_k127_6449295_6 880073.Calab_2949 1.095e-57 212.0 COG3137@1|root,COG3137@2|Bacteria 2|Bacteria - - ydiY - - ko:K07283 - - - - ko00000 - - - DUF3078,DUF481 SRD1_k127_6449295_1 575540.Isop_3575 6.93e-183 584.0 COG0531@1|root,COG0531@2|Bacteria,2IXT5@203682|Planctomycetes 203682|Planctomycetes E PFAM Amino acid permease - - - ko:K03294 - - - - ko00000 2.A.3.2 - - AA_permease_2 SRD1_k127_6449295_3 886293.Sinac_0940 6.869e-147 483.0 COG2234@1|root,COG2234@2|Bacteria,2IZHS@203682|Planctomycetes 203682|Planctomycetes S Peptidase family M28 - - - - - - - - - - - - Peptidase_M28 SRD1_k127_6449295_9 694427.Palpr_2248 5.394e-21 99.0 2C5N5@1|root,32Y15@2|Bacteria,4NZ8K@976|Bacteroidetes,2FS1I@200643|Bacteroidia 976|Bacteroidetes S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - - SRD1_k127_6449295_8 314278.NB231_00999 1.287e-29 119.0 COG1522@1|root,COG1522@2|Bacteria,1NC1H@1224|Proteobacteria,1SE9N@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Transcriptional - - - - - - - - - - - - AsnC_trans_reg SRD1_k127_6449295_2 945713.IALB_1605 2.943e-155 503.0 COG3579@1|root,COG3579@2|Bacteria 2|Bacteria E homocysteine catabolic process - - 3.4.22.40 ko:K01372,ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko01002,ko03032 - - - Peptidase_C1,Peptidase_C1_2 SRD1_k127_6449295_0 880073.Calab_3738 2.717e-206 662.0 COG0322@1|root,COG0322@2|Bacteria,2NNQ4@2323|unclassified Bacteria 2|Bacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision uvrC GO:0005575,GO:0005622,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0032991,GO:0033554,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N SRD1_k127_6449295_4 1519464.HY22_09070 7.029e-128 426.0 COG0308@1|root,COG0308@2|Bacteria 2|Bacteria E peptide catabolic process pepN1 - - - - - - - - - - - Peptidase_M1 SRD1_k127_6455516_3 1191523.MROS_0100 4.232e-82 276.0 COG1012@1|root,COG1012@2|Bacteria 2|Bacteria C belongs to the aldehyde dehydrogenase family eutE GO:0003674,GO:0003824,GO:0004029,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114 1.2.1.87 ko:K04021,ko:K13922 ko00620,ko00640,ko01100,ko01120,map00620,map00640,map01100,map01120 - R00228,R09097 RC00004,RC00184,RC01195 ko00000,ko00001,ko01000 - - - Aldedh SRD1_k127_6455516_5 1191523.MROS_0099 1.806e-36 139.0 COG4577@1|root,COG4577@2|Bacteria 2|Bacteria CQ ethanolamine catabolic process ccmO - - ko:K04027,ko:K08696,ko:K08700 - - - - ko00000 - - - BMC SRD1_k127_6455516_6 1191523.MROS_0098 2.772e-36 139.0 COG4576@1|root,COG4576@2|Bacteria 2|Bacteria CQ ethanolamine utilization protein EutN carboxysome structural protein Ccml - - - ko:K04028,ko:K08697 - - - - ko00000 - - - EutN_CcmL SRD1_k127_6455516_9 1191523.MROS_0097 3.017e-28 120.0 COG4576@1|root,COG4576@2|Bacteria 2|Bacteria CQ ethanolamine utilization protein EutN carboxysome structural protein Ccml eutN - - ko:K04028 - - - - ko00000 - - - EutN_CcmL SRD1_k127_6455516_8 1191523.MROS_0096 2.601e-29 125.0 COG4576@1|root,COG4576@2|Bacteria 2|Bacteria CQ ethanolamine utilization protein EutN carboxysome structural protein Ccml eutN GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0050896,GO:0051716 - ko:K04028 - - - - ko00000 - - - EutN_CcmL SRD1_k127_6455516_1 1121403.AUCV01000053_gene2639 6.001e-118 395.0 COG4656@1|root,COG4656@2|Bacteria,1PJE1@1224|Proteobacteria,42P69@68525|delta/epsilon subdivisions,2WIM9@28221|Deltaproteobacteria,2MI2H@213118|Desulfobacterales 28221|Deltaproteobacteria C Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily - - - - - - - - - - - - Complex1_51K,Fer4_17,RnfC_N,SLBB SRD1_k127_6455516_4 880073.Calab_1627 1.126e-39 155.0 COG4577@1|root,COG4577@2|Bacteria,2NRES@2323|unclassified Bacteria 2|Bacteria CQ BMC - - - ko:K04025 - - - - ko00000 - - - BMC SRD1_k127_6455516_2 1191523.MROS_0095 1.803e-114 374.0 COG0235@1|root,COG0235@2|Bacteria 2|Bacteria G Class ii aldolase fucA - 2.7.1.189,4.1.2.17,5.1.3.4 ko:K01628,ko:K03077,ko:K11216 ko00040,ko00051,ko00053,ko01100,ko01120,ko02024,map00040,map00051,map00053,map01100,map01120,map02024 M00550 R02262,R05850,R11183 RC00002,RC00017,RC00603,RC00604,RC01479 ko00000,ko00001,ko00002,ko01000 - - - Aldolase_II SRD1_k127_6455516_0 1191523.MROS_0094 3.377e-167 535.0 COG0282@1|root,COG0282@2|Bacteria 2|Bacteria F acetate kinase activity ackA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.7.2.1,2.7.2.15 ko:K00925,ko:K19697 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00315,R01353 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - iNJ661.Rv0409 Acetate_kinase SRD1_k127_6455516_11 32264.tetur16g00850.1 0.0003423 53.0 KOG2649@1|root,KOG2649@2759|Eukaryota,38DE0@33154|Opisthokonta,3B9RU@33208|Metazoa 33208|Metazoa J metallocarboxypeptidase activity - - 3.4.17.22 ko:K07752 - - - - ko00000,ko01000,ko01002 - - - CarboxypepD_reg,Peptidase_M14 SRD1_k127_6455516_7 1047013.AQSP01000137_gene558 3.136e-36 155.0 COG2866@1|root,COG2866@2|Bacteria,2NPI7@2323|unclassified Bacteria 2|Bacteria E Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - 3.4.17.18,3.4.17.22 ko:K05996,ko:K07752 - - - - ko00000,ko01000,ko01002 - - - CarboxypepD_reg,Peptidase_M14,Peptidase_M6,fn3 SRD1_k127_6455516_10 1379698.RBG1_1C00001G1616 5.037e-12 67.0 COG0515@1|root,COG0515@2|Bacteria,2NQWH@2323|unclassified Bacteria 2|Bacteria KLT Protein tyrosine kinase - - - - - - - - - - - - Pkinase,TPR_8 SRD1_k127_6461725_0 945713.IALB_1764 4.218e-206 672.0 COG5448@1|root,COG5448@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - DUF2460 SRD1_k127_6465904_1 945713.IALB_1382 8.356e-31 135.0 COG4856@1|root,COG4856@2|Bacteria 2|Bacteria O YbbR-like protein ybbR GO:0008150,GO:0031279,GO:0031281,GO:0043085,GO:0044093,GO:0045761,GO:0045762,GO:0050790,GO:0051339,GO:0051349,GO:0065007,GO:0065009 - - - - - - - - - - YbbR SRD1_k127_6465904_0 517418.Ctha_0038 9.973e-77 280.0 COG5617@1|root,COG5617@2|Bacteria,1FDV6@1090|Chlorobi 1090|Chlorobi S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - YfhO SRD1_k127_6486250_3 62928.azo1111 1.852e-27 117.0 COG2703@1|root,COG2703@2|Bacteria,1RK9A@1224|Proteobacteria,2VT8G@28216|Betaproteobacteria,2KWR8@206389|Rhodocyclales 206389|Rhodocyclales P Hemerythrin-like metal-binding protein - - - ko:K07216 - - - - ko00000 - - - Hemerythrin SRD1_k127_6486250_1 1408473.JHXO01000005_gene1751 2.007e-126 427.0 COG1180@1|root,COG1180@2|Bacteria,4NJ18@976|Bacteroidetes,2FQZB@200643|Bacteroidia 976|Bacteroidetes O radical SAM domain protein - - 1.97.1.4 ko:K04069 - - R04710 - ko00000,ko01000 - - - Fer4_12,Radical_SAM SRD1_k127_6486250_2 713587.THITH_12510 4.357e-69 262.0 COG0421@1|root,COG0421@2|Bacteria,1MVV5@1224|Proteobacteria 1224|Proteobacteria E Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine speE - 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - Spermine_synth SRD1_k127_6486250_0 385682.AFSL01000083_gene1154 5.224e-136 451.0 COG1355@1|root,COG2078@1|root,COG1355@2|Bacteria,COG2078@2|Bacteria,4NKA5@976|Bacteroidetes,2FRBU@200643|Bacteroidia,3XJT2@558415|Marinilabiliaceae 976|Bacteroidetes S Memo-like protein - - - ko:K06990 - - - - ko00000,ko04812 - - - AMMECR1,Memo SRD1_k127_6486250_4 378806.STAUR_4879 1.508e-05 53.0 COG2010@1|root,COG2010@2|Bacteria 2|Bacteria C Cytochrome c adhB - - - - - - - - - - - Cytochrom_C,Cytochrome_CBB3 SRD1_k127_6505496_2 869213.JCM21142_466 1.66e-63 229.0 COG0348@1|root,COG0437@1|root,COG0348@2|Bacteria,COG0437@2|Bacteria,4NHSX@976|Bacteroidetes 976|Bacteroidetes C 4Fe-4S binding domain protein yccM_2 - - - - - - - - - - - Fer4,Fer4_5,Fer4_7,Fer4_9 SRD1_k127_6505496_0 879212.DespoDRAFT_02025 5.124e-126 412.0 COG2006@1|root,COG2006@2|Bacteria,1QMGX@1224|Proteobacteria,42PRJ@68525|delta/epsilon subdivisions,2WMFN@28221|Deltaproteobacteria,2MIED@213118|Desulfobacterales 28221|Deltaproteobacteria S Domain of unknown function (DUF362) - - - - - - - - - - - - DUF362 SRD1_k127_6505496_1 880073.Calab_1337 7.137e-118 394.0 COG1123@1|root,COG4172@2|Bacteria 2|Bacteria P Belongs to the ABC transporter superfamily - - - ko:K02031,ko:K02032 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY SRD1_k127_6520126_0 945713.IALB_0785 1.555e-169 539.0 COG1816@1|root,COG1816@2|Bacteria 2|Bacteria F deaminase activity add GO:0003674,GO:0003824,GO:0004000,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006144,GO:0006152,GO:0006154,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009113,GO:0009116,GO:0009119,GO:0009163,GO:0009164,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017144,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042278,GO:0042440,GO:0042451,GO:0042454,GO:0042455,GO:0042737,GO:0043094,GO:0043096,GO:0043101,GO:0043103,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046085,GO:0046100,GO:0046101,GO:0046102,GO:0046103,GO:0046112,GO:0046128,GO:0046129,GO:0046130,GO:0046148,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0072523,GO:1901135,GO:1901136,GO:1901137,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901658,GO:1901659 3.5.4.4 ko:K01488 ko00230,ko01100,ko05340,map00230,map01100,map05340 - R01560,R02556 RC00477 ko00000,ko00001,ko01000 - - iNJ661.Rv3313c A_deaminase SRD1_k127_6520126_1 247490.KSU1_D0366 1.161e-121 405.0 COG2204@1|root,COG2204@2|Bacteria,2IXMN@203682|Planctomycetes 203682|Planctomycetes T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains - - - ko:K02481 - - - - ko00000,ko02022 - - - HTH_8,Response_reg,Sigma54_activat SRD1_k127_6520126_2 880073.Calab_1153 8.829e-25 110.0 COG0591@1|root,COG0591@2|Bacteria,2NRJT@2323|unclassified Bacteria 2|Bacteria E Sodium:solute symporter family - - - ko:K03307 - - - - ko00000 2.A.21 - - SSF SRD1_k127_6523821_0 29581.BW37_03920 9.457e-72 254.0 COG2972@1|root,COG2972@2|Bacteria,1MXVQ@1224|Proteobacteria,2W9CU@28216|Betaproteobacteria,4769K@75682|Oxalobacteraceae 28216|Betaproteobacteria T Histidine kinase - - - - - - - - - - - - His_kinase SRD1_k127_6523821_1 883126.HMPREF9710_04256 7.063e-54 199.0 COG4758@1|root,COG4758@2|Bacteria,1RFX6@1224|Proteobacteria,2WCSU@28216|Betaproteobacteria,4772Z@75682|Oxalobacteraceae 28216|Betaproteobacteria S membrane - - - - - - - - - - - - - SRD1_k127_6523821_2 1191523.MROS_1591 3.16e-38 154.0 COG3525@1|root,COG3525@2|Bacteria 2|Bacteria G beta-N-acetylhexosaminidase activity - - 3.2.1.52 ko:K12373 ko00511,ko00513,ko00520,ko00531,ko00603,ko00604,ko01100,ko04142,map00511,map00513,map00520,map00531,map00603,map00604,map01100,map04142 M00079 R00022,R06004,R11316 RC00049 ko00000,ko00001,ko00002,ko01000,ko03110 - GH20 - CHB_HEX_C_1,F5_F8_type_C,Fn3_assoc,Glyco_hydro_20,Glyco_hydro_20b SRD1_k127_6533134_0 330214.NIDE0254 3.322e-123 407.0 COG0006@1|root,COG0006@2|Bacteria 2|Bacteria E proline dipeptidase activity - - 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M24 SRD1_k127_6533134_3 1191523.MROS_0851 1.005e-65 233.0 COG1277@1|root,COG1277@2|Bacteria 2|Bacteria - - - - - ko:K01992,ko:K19341 ko02010,map02010 M00254,M00762 - - ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.132.2 - - ABC2_membrane_2 SRD1_k127_6533134_1 526227.Mesil_0791 1.826e-72 255.0 COG1131@1|root,COG1131@2|Bacteria,1WMG4@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus V COGs COG1131 ABC-type multidrug transport system ATPase component - - - ko:K01990,ko:K20459 ko02010,map02010 M00254,M00813 - - ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.124.3,3.A.1.124.4,3.A.1.124.5 - - ABC_tran SRD1_k127_6533134_2 1191523.MROS_2275 5.725e-67 245.0 COG0544@1|root,COG0544@2|Bacteria 2|Bacteria D peptidyl-prolyl cis-trans isomerase activity tig GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006464,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0036211,GO:0042802,GO:0043021,GO:0043022,GO:0043170,GO:0043335,GO:0043412,GO:0044183,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0050896,GO:0051083,GO:0061077,GO:0071704,GO:0140096,GO:1901564 - ko:K03545 - - - - ko00000 - - - FKBP_C,Trigger_C,Trigger_N SRD1_k127_6533134_4 391009.Tmel_0984 3.807e-23 105.0 COG0740@1|root,COG0740@2|Bacteria,2GC7E@200918|Thermotogae 200918|Thermotogae O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins clpP - 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 - - - ko00000,ko00001,ko01000,ko01002 - - - CLP_protease SRD1_k127_6556512_1 1121920.AUAU01000004_gene855 9.275e-58 204.0 COG0066@1|root,COG0066@2|Bacteria 2|Bacteria E 3-isopropylmalate dehydratase activity leuD - 4.2.1.33,4.2.1.35 ko:K01704 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R10170 RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase_C SRD1_k127_6556512_2 330214.NIDE3895 1.449e-31 131.0 COG1764@1|root,COG1764@2|Bacteria 2|Bacteria O response to oxidative stress ymaD - - ko:K04063 - - - - ko00000 - - - OsmC SRD1_k127_6556512_0 945713.IALB_0538 1.3e-90 304.0 COG0635@1|root,COG0635@2|Bacteria 2|Bacteria H coproporphyrinogen oxidase activity hemN GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0051989,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.98.3 ko:K02495 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R06895 RC00884 ko00000,ko00001,ko00002,ko01000 - - iECIAI39_1322.ECIAI39_3134,iZ_1308.Z5403 HemN_C,Radical_SAM SRD1_k127_6558104_4 517418.Ctha_1210 6.768e-41 158.0 COG0845@1|root,COG0845@2|Bacteria,1FE89@1090|Chlorobi 1090|Chlorobi M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - HlyD_D23 SRD1_k127_6558104_1 517418.Ctha_1209 3.405e-272 872.0 COG0841@1|root,COG0841@2|Bacteria,1FDQI@1090|Chlorobi 1090|Chlorobi V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran SRD1_k127_6558104_3 945713.IALB_2677 2.069e-41 177.0 2D6MI@1|root,32TMJ@2|Bacteria 2|Bacteria S PAP2 superfamily C-terminal - - - - - - - - - - - - PAP2_C SRD1_k127_6558104_0 204669.Acid345_1956 3.291e-286 915.0 COG1501@1|root,COG1501@2|Bacteria 2|Bacteria G Belongs to the glycosyl hydrolase 31 family xylS - 3.2.1.20 ko:K01187 ko00052,ko00500,ko01100,map00052,map00500,map01100 - R00028,R00801,R00802,R06087,R06088 RC00028,RC00049,RC00077 ko00000,ko00001,ko01000 - GH31 - DUF4968,DUF5110,Glyco_hydro_31 SRD1_k127_6558104_2 243231.GSU0479 8.38e-146 472.0 COG1027@1|root,COG1027@2|Bacteria,1R9JY@1224|Proteobacteria,42MFS@68525|delta/epsilon subdivisions,2X6YF@28221|Deltaproteobacteria,43TQ6@69541|Desulfuromonadales 28221|Deltaproteobacteria E Fumarase C C-terminus aspA - 4.3.1.1 ko:K01744 ko00250,ko01100,map00250,map01100 - R00490 RC00316,RC02799 ko00000,ko00001,ko01000 - - - FumaraseC_C,Lyase_1,cNMP_binding SRD1_k127_6560821_1 880073.Calab_0292 3.63e-32 142.0 COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,2NNNP@2323|unclassified Bacteria 2|Bacteria D CobQ CobB MinD ParA nucleotide binding domain - - - ko:K16554,ko:K16692 ko05111,map05111 - - - ko00000,ko00001,ko01000,ko01001,ko02000 8.A.3.1 - - AAA_31,CbiA,GNVR,ParA,Wzz SRD1_k127_6560821_0 1267535.KB906767_gene4368 3.358e-129 424.0 COG0399@1|root,COG0399@2|Bacteria,3Y2QT@57723|Acidobacteria 57723|Acidobacteria E DegT/DnrJ/EryC1/StrS aminotransferase family - - 2.6.1.102 ko:K13010 ko00520,map00520 - R10460 RC00006,RC00781 ko00000,ko00001,ko01000,ko01005,ko01007 - - - DegT_DnrJ_EryC1 SRD1_k127_6560821_2 497964.CfE428DRAFT_4629 2.029e-20 92.0 COG1052@1|root,COG1052@2|Bacteria,46SSP@74201|Verrucomicrobia 74201|Verrucomicrobia CH D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain - - - - - - - - - - - - 2-Hacid_dh,2-Hacid_dh_C SRD1_k127_656116_10 1168034.FH5T_17615 7.805e-50 188.0 28H5M@1|root,2Z7I7@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - SRD1_k127_656116_13 1382359.JIAL01000001_gene1809 0.000408 43.0 COG3391@1|root,COG3391@2|Bacteria,3Y48Y@57723|Acidobacteria,2JJ87@204432|Acidobacteriia 204432|Acidobacteriia S YVTN family beta-propeller repeat - - - - - - - - - - - - SGL SRD1_k127_656116_11 319225.Plut_0973 8.732e-38 155.0 COG0392@1|root,COG0392@2|Bacteria,1FDR1@1090|Chlorobi 1090|Chlorobi S Lysylphosphatidylglycerol synthase TM region - - - - - - - - - - - - LPG_synthase_TM SRD1_k127_656116_2 517418.Ctha_2087 3.661e-142 462.0 COG1887@1|root,COG1887@2|Bacteria,1FDQ2@1090|Chlorobi 1090|Chlorobi M Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC - - - - - - - - - - - - - SRD1_k127_656116_7 1519464.HY22_10750 1.337e-104 347.0 COG1861@1|root,COG1861@2|Bacteria,1FEGX@1090|Chlorobi 1090|Chlorobi M Cytidylyltransferase - - - - - - - - - - - - CTP_transf_3 SRD1_k127_656116_4 517418.Ctha_2089 1.475e-125 410.0 COG3959@1|root,COG3959@2|Bacteria,1FEZ6@1090|Chlorobi 1090|Chlorobi G XFP N-terminal domain - - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transketolase_N SRD1_k127_656116_6 517418.Ctha_2090 5.883e-112 369.0 COG3958@1|root,COG3958@2|Bacteria,1FDB9@1090|Chlorobi 2|Bacteria G PFAM Transketolase central region - - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C SRD1_k127_656116_0 945713.IALB_1521 2.627e-217 689.0 COG0001@1|root,COG0001@2|Bacteria 2|Bacteria H glutamate-1-semialdehyde 2,1-aminomutase activity hemL - 5.4.3.8 ko:K01845,ko:K07257 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Amidohydro_2,Aminotran_3,CTP_transf_3 SRD1_k127_656116_5 517418.Ctha_2576 3.11e-115 376.0 COG1028@1|root,COG1028@2|Bacteria,1FEX2@1090|Chlorobi 1090|Chlorobi IQ Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short_C2 SRD1_k127_656116_9 331678.Cphamn1_1194 1.811e-54 206.0 COG1778@1|root,COG1778@2|Bacteria,1FDY4@1090|Chlorobi 1090|Chlorobi C TIGRFAM 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family - - 3.1.3.45 ko:K03270 ko00540,ko01100,map00540,map01100 M00063 R03350 RC00017 ko00000,ko00001,ko00002,ko01000,ko01005 - - - - SRD1_k127_656116_3 517418.Ctha_2574 2.612e-140 452.0 COG2089@1|root,COG2089@2|Bacteria,1FD73@1090|Chlorobi 1090|Chlorobi H PFAM N-acetylneuraminic acid synthase - - 2.5.1.56 ko:K01654 ko00520,ko01100,map00520,map01100 - R01804,R04435 RC00159 ko00000,ko00001,ko01000 - - - NeuB SRD1_k127_656116_8 517418.Ctha_2573 3.005e-92 312.0 COG3000@1|root,COG3000@2|Bacteria 2|Bacteria I iron ion binding - - - - - - - - - - - - FA_hydroxylase SRD1_k127_656116_1 935948.KE386494_gene961 2.389e-165 532.0 arCOG03330@1|root,2Z82Q@2|Bacteria,1U584@1239|Firmicutes,24B07@186801|Clostridia,42FIS@68295|Thermoanaerobacterales 186801|Clostridia H Methanol-cobalamin methyltransferase B subunit - - 2.1.1.90 ko:K04480 ko00680,ko01120,ko01200,map00680,map01120,map01200 M00356 R04384,R09098 RC00035,RC01144,RC01145,RC02440 ko00000,ko00001,ko00002,ko01000 - - - MtaB SRD1_k127_656116_12 404589.Anae109_3494 4.235e-19 93.0 COG1832@1|root,COG1832@2|Bacteria,1NJW8@1224|Proteobacteria,42WY1@68525|delta/epsilon subdivisions,2WT3S@28221|Deltaproteobacteria,2Z10K@29|Myxococcales 28221|Deltaproteobacteria S CoA binding domain - - - - - - - - - - - - CoA_binding_2 SRD1_k127_6568498_1 945713.IALB_0983 4.097e-86 295.0 COG4299@1|root,COG4299@2|Bacteria 2|Bacteria G COGs COG4299 conserved - - - - - - - - - - - - DUF1624,DUF5009 SRD1_k127_6568498_0 945713.IALB_1298 8.228e-285 893.0 COG0363@1|root,COG0363@2|Bacteria 2|Bacteria G glucosamine-6-phosphate deaminase activity nagB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 3.1.1.31,3.5.99.6 ko:K01057,ko:K02564 ko00030,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00520,map01100,map01110,map01120,map01130,map01200 M00004,M00006,M00008 R00765,R02035 RC00163,RC00537 ko00000,ko00001,ko00002,ko01000 - - - Glucosamine_iso,PIG-L SRD1_k127_6577850_1 880073.Calab_3508 1.938e-29 123.0 COG1446@1|root,COG1446@2|Bacteria,2NPFC@2323|unclassified Bacteria 2|Bacteria E Asparaginase asnA2 GO:0005575,GO:0005623,GO:0042597,GO:0044464 3.4.19.5,3.5.1.1,3.5.1.26 ko:K01424,ko:K01444,ko:K13051 ko00250,ko00460,ko00511,ko01100,ko01110,ko04142,map00250,map00460,map00511,map01100,map01110,map04142 - R00485 RC00010,RC02798 ko00000,ko00001,ko01000,ko01002 - - - Asparaginase_2 SRD1_k127_6577850_0 1173028.ANKO01000021_gene3778 2.88e-66 233.0 COG1187@1|root,COG1187@2|Bacteria,1G56K@1117|Cyanobacteria,1H75S@1150|Oscillatoriales 1117|Cyanobacteria J Belongs to the pseudouridine synthase RsuA family - GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.20 ko:K06181 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2 SRD1_k127_6577850_2 309807.SRU_2847 2.097e-22 102.0 COG4206@1|root,COG4206@2|Bacteria,4PF18@976|Bacteroidetes,1FJZF@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes H CarboxypepD_reg-like domain - - - - - - - - - - - - CarbopepD_reg_2 SRD1_k127_6595903_0 929556.Solca_3158 2.397e-266 832.0 COG0841@1|root,COG0841@2|Bacteria,4NDZG@976|Bacteroidetes,1IP63@117747|Sphingobacteriia 976|Bacteroidetes V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family bepE_4 - - ko:K03296,ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran SRD1_k127_6595903_2 237368.SCABRO_02567 3.379e-125 409.0 COG0845@1|root,COG0845@2|Bacteria,2J0I9@203682|Planctomycetes 203682|Planctomycetes M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K18306 ko02024,map02024 M00644 - - ko00000,ko00001,ko00002,ko02000 2.A.6.2.20,2.A.6.2.32,8.A.1 - - HlyD_D23 SRD1_k127_6595903_1 700598.Niako_6291 1.346e-125 427.0 COG3087@1|root,COG3087@2|Bacteria,4PNV5@976|Bacteroidetes 976|Bacteroidetes D Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides - - - - - - - - - - - - - SRD1_k127_6631478_1 1191523.MROS_0752 1.303e-194 635.0 COG3934@1|root,COG3934@2|Bacteria 2|Bacteria G Belongs to the glycosyl hydrolase 5 (cellulase A) family - - - - - - - - - - - - CBM_4_9,Cellulase,Glyco_hydro_2_C,Glycos_transf_2 SRD1_k127_6631478_5 518766.Rmar_2616 6.66e-10 63.0 COG1472@1|root,COG1472@2|Bacteria,4NE90@976|Bacteroidetes,1FIS9@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes G PFAM glycoside hydrolase family 3 domain protein - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C SRD1_k127_6631478_0 945713.IALB_2594 1.146e-267 849.0 COG1472@1|root,COG1472@2|Bacteria 2|Bacteria G Belongs to the glycosyl hydrolase 3 family - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C,PA14 SRD1_k127_6631478_4 1216967.L100_09774 1.71e-22 101.0 COG4272@1|root,COG4272@2|Bacteria,4NSD4@976|Bacteroidetes,1IIF2@117743|Flavobacteriia,34RJI@308865|Elizabethkingia 976|Bacteroidetes S Protein of unknown function (DUF1634) - - - - - - - - - - - - DUF1634 SRD1_k127_6631478_3 517417.Cpar_1018 5.59e-104 345.0 COG0730@1|root,COG0730@2|Bacteria 2|Bacteria S response to heat yxaA - - ko:K07090 - - - - ko00000 - - - TauE SRD1_k127_6631478_2 1499967.BAYZ01000195_gene3087 1.171e-126 422.0 COG0265@1|root,COG0265@2|Bacteria,2NNVS@2323|unclassified Bacteria 2|Bacteria O smart pdz dhr glgf htrA GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.107 ko:K04771,ko:K04772 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ,PDZ_2,Trypsin_2 SRD1_k127_6631478_6 1009370.ALO_17551 1.492e-09 58.0 COG5002@1|root,COG5002@2|Bacteria,1TS83@1239|Firmicutes,4H2Z6@909932|Negativicutes 909932|Negativicutes T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA SRD1_k127_6636899_0 290315.Clim_1096 7.334e-79 274.0 COG1092@1|root,COG1092@2|Bacteria,1FDS5@1090|Chlorobi 1090|Chlorobi J SMART PUA domain containing protein - - 2.1.1.191 ko:K06969 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_SAM SRD1_k127_6638946_3 1122223.KB890697_gene1094 5.31e-27 110.0 COG0274@1|root,COG0274@2|Bacteria,1WI7Y@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate deoC GO:0003674,GO:0003824,GO:0004139,GO:0005975,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009262,GO:0009264,GO:0009987,GO:0016052,GO:0016829,GO:0016830,GO:0016832,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 4.1.2.4 ko:K01619 ko00030,map00030 - R01066 RC00436,RC00437 ko00000,ko00001,ko01000 - - - DeoC SRD1_k127_6638946_0 1122221.JHVI01000001_gene1847 8.01e-278 875.0 COG1012@1|root,COG1012@2|Bacteria,1WIGH@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus C Belongs to the aldehyde dehydrogenase family - - 1.2.1.3 ko:K00128 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh SRD1_k127_6638946_2 204669.Acid345_3867 3.997e-51 190.0 COG1280@1|root,COG1280@2|Bacteria 2|Bacteria E homoserine transmembrane transporter activity chpE - - ko:K06600,ko:K06895 - - - - ko00000,ko02000,ko02035 2.A.75.1,2.A.76 - - LysE SRD1_k127_6638946_1 644966.Tmar_0252 6.966e-72 260.0 COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,1TPE2@1239|Firmicutes,25CRT@186801|Clostridia 186801|Clostridia P Rhodanese Homology Domain - - - - - - - - - - - - Lactamase_B,Rhodanese SRD1_k127_6648934_0 518766.Rmar_0629 2.772e-142 479.0 COG0823@1|root,COG4775@1|root,COG0823@2|Bacteria,COG4775@2|Bacteria,4NERT@976|Bacteroidetes,1FJ3R@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes MU WD40-like Beta Propeller Repeat - - - - - - - - - - - - BSP,Bac_surface_Ag,PD40 SRD1_k127_6651782_0 1303518.CCALI_00294 1.91e-254 811.0 COG4354@1|root,COG4354@2|Bacteria 2|Bacteria G intracellular protein transport - - - - - - - - - - - - DUF608,Glyco_hydr_116N SRD1_k127_6677368_1 357808.RoseRS_1474 8.018e-25 111.0 COG0758@1|root,COG0758@2|Bacteria 2|Bacteria LU DNA mediated transformation dprA - - ko:K04096 - - - - ko00000 - - - DNA_processg_A SRD1_k127_6677368_2 945713.IALB_1563 9.133e-24 111.0 2ETT1@1|root,33MAE@2|Bacteria 2|Bacteria S Protein of unknown function (DUF3108) - - - - - - - - - - - - DUF3108 SRD1_k127_6677368_0 1191523.MROS_1651 3.41e-91 307.0 COG0348@1|root,COG0437@1|root,COG0348@2|Bacteria,COG0437@2|Bacteria 2|Bacteria C 4 iron, 4 sulfur cluster binding yccM_2 - - ko:K02573 - - - - ko00000 - - - Fer4,Fer4_4,Fer4_5,Fer4_6,Fer4_7,Fer4_8 SRD1_k127_6696130_0 309807.SRU_1916 5.669e-39 160.0 COG2356@1|root,COG2374@1|root,COG2356@2|Bacteria,COG2374@2|Bacteria,4PM65@976|Bacteroidetes,1FKEM@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes L Endonuclease I - - - - - - - - - - - - Endonuclease_1 SRD1_k127_6698119_3 1191523.MROS_0090 8.757e-24 102.0 COG1070@1|root,COG1070@2|Bacteria 2|Bacteria G xylulokinase activity rhaB GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005975,GO:0005996,GO:0006793,GO:0006796,GO:0008144,GO:0008150,GO:0008152,GO:0008993,GO:0009056,GO:0009987,GO:0016052,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0019200,GO:0019299,GO:0019301,GO:0019318,GO:0019320,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0046365,GO:0046835,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901575 2.7.1.17,2.7.1.5 ko:K00848,ko:K00854 ko00040,ko00051,ko01100,ko01120,map00040,map00051,map01100,map01120 M00014 R01639,R01902,R03014 RC00002,RC00017,RC00538 ko00000,ko00001,ko00002,ko01000 - - iEcE24377_1341.EcE24377A_4435 FGGY_C,FGGY_N SRD1_k127_6698119_0 65497.JODV01000016_gene3232 2.33e-75 268.0 COG4952@1|root,COG4952@2|Bacteria,2GK1Z@201174|Actinobacteria,4DZ7P@85010|Pseudonocardiales 201174|Actinobacteria M Isomerase rhaA - 5.3.1.14 ko:K01820 ko00040,ko00051,ko01120,map00040,map00051,map01120 - R01906,R02437,R06589 RC00376,RC00434,RC00516 ko00000,ko00001,ko01000 - - - RhaA SRD1_k127_6698119_2 670307.HYPDE_24563 4.016e-39 153.0 COG2259@1|root,COG2259@2|Bacteria,1N072@1224|Proteobacteria,2UCXT@28211|Alphaproteobacteria,3N8UB@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria S DoxX family - - - ko:K15977 - - - - ko00000 - - - DoxX SRD1_k127_6698119_4 1382315.JPOI01000001_gene2020 9.93e-23 101.0 COG4994@1|root,COG4994@2|Bacteria,1VC72@1239|Firmicutes,4HMHY@91061|Bacilli,1WGRP@129337|Geobacillus 91061|Bacilli S Domain of unknown function (DUF4440) - - - - - - - - - - - - DUF4440 SRD1_k127_6698119_1 443143.GM18_1262 1.345e-45 170.0 COG4832@1|root,COG4832@2|Bacteria,1RBGY@1224|Proteobacteria,42VX0@68525|delta/epsilon subdivisions,2WRUN@28221|Deltaproteobacteria 28221|Deltaproteobacteria S GyrI-like small molecule binding domain - - - - - - - - - - - - GyrI-like SRD1_k127_6699286_2 706587.Desti_0382 3.105e-39 152.0 COG0531@1|root,COG0531@2|Bacteria,1R829@1224|Proteobacteria,42MS5@68525|delta/epsilon subdivisions,2WINQ@28221|Deltaproteobacteria,2MSEM@213462|Syntrophobacterales 28221|Deltaproteobacteria E Amino acid permease - - - - - - - - - - - - AA_permease_2 SRD1_k127_6699286_1 1341151.ASZU01000021_gene1268 1.526e-51 191.0 COG1211@1|root,COG1211@2|Bacteria,1V3M7@1239|Firmicutes,4HH2N@91061|Bacilli,27BZE@186824|Thermoactinomycetaceae 91061|Bacilli I 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase ispD GO:0003674,GO:0003824,GO:0016740,GO:0016772,GO:0016779,GO:0050518,GO:0070567 2.7.7.60 ko:K00991 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05633 RC00002 ko00000,ko00001,ko00002,ko01000 - - - IspD SRD1_k127_6699286_0 945713.IALB_3095 4.66e-79 270.0 COG0344@1|root,COG0344@2|Bacteria 2|Bacteria I acyl-phosphate glycerol-3-phosphate acyltransferase activity plsY - 2.3.1.15 ko:K08591 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - G3P_acyltransf SRD1_k127_6699286_3 517417.Cpar_2000 1.816e-13 70.0 COG0240@1|root,COG0240@2|Bacteria,1FDCM@1090|Chlorobi 1090|Chlorobi I NAD-dependent glycerol-3-phosphate dehydrogenase domain protein gpsA - 1.1.1.94 ko:K00057 ko00564,ko01110,map00564,map01110 - R00842,R00844 RC00029 ko00000,ko00001,ko01000 - - - NAD_Gly3P_dh_C,NAD_Gly3P_dh_N SRD1_k127_670542_4 1321786.HMPREF1992_00252 2.998e-35 144.0 COG0163@1|root,COG0163@2|Bacteria,1V3JV@1239|Firmicutes,4H44P@909932|Negativicutes 909932|Negativicutes H Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN ubiX - 2.5.1.129 ko:K03186 ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220 M00117 R01238,R02952,R03367,R04985,R04986,R11225 RC00391,RC00814,RC03392 ko00000,ko00001,ko00002,ko01000 - - - Flavoprotein SRD1_k127_670542_2 572546.Arcpr_1251 3.474e-51 194.0 COG0382@1|root,arCOG00477@2157|Archaea,2XW9S@28890|Euryarchaeota,24617@183980|Archaeoglobi 183980|Archaeoglobi H 4-hydroxybenzoate polyprenyltransferase - - 2.5.1.39 ko:K03179 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R05000,R05615 RC00209,RC02895 ko00000,ko00001,ko00002,ko01000,ko01006 - - - UbiA SRD1_k127_670542_0 290397.Adeh_2348 1.43e-214 681.0 COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,42M0I@68525|delta/epsilon subdivisions,2WJ6D@28221|Deltaproteobacteria,2YTZV@29|Myxococcales 28221|Deltaproteobacteria F Catalyzes the synthesis of GMP from XMP guaA GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase,GMP_synt_C,NAD_synthase,tRNA_Me_trans SRD1_k127_670542_1 1191523.MROS_0152 5.202e-188 597.0 COG2403@1|root,COG2403@2|Bacteria 2|Bacteria S cyclic 2,3-diphosphoglycerate synthetase activity cpgS - - ko:K05716 - - R03298 RC00900 ko00000,ko01000 - - - cobW SRD1_k127_670542_3 375286.mma_3569 1.143e-35 139.0 COG0549@1|root,COG0549@2|Bacteria,1MWXC@1224|Proteobacteria,2VM5W@28216|Betaproteobacteria 28216|Betaproteobacteria E Belongs to the carbamate kinase family - - 2.7.2.2 ko:K00926 ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200 - R00150,R01395 RC00002,RC00043,RC02803,RC02804 ko00000,ko00001,ko01000 - - - AA_kinase SRD1_k127_6719086_0 234267.Acid_0399 2.466e-109 357.0 COG5557@1|root,COG5557@2|Bacteria,3Y3RF@57723|Acidobacteria 2|Bacteria C Polysulphide reductase, NrfD qrcD - - ko:K00185 - - - - ko00000 5.A.3 - - NrfD SRD1_k127_6719086_1 234267.Acid_0400 8.464e-100 331.0 COG0437@1|root,COG0437@2|Bacteria,3Y2Z0@57723|Acidobacteria 57723|Acidobacteria C 4Fe-4S dicluster domain - - - ko:K00184 - - - - ko00000 5.A.3 - - - SRD1_k127_674413_2 344747.PM8797T_29143 8.518e-06 54.0 COG0591@1|root,COG0591@2|Bacteria 2|Bacteria E symporter activity - - - ko:K03307 - - - - ko00000 2.A.21 - - SSF SRD1_k127_674413_0 485917.Phep_3108 3.664e-96 329.0 COG4225@1|root,COG4225@2|Bacteria,4NH7G@976|Bacteroidetes,1IRFG@117747|Sphingobacteriia 976|Bacteroidetes S Glycosyl Hydrolase Family 88 - - - - - - - - - - - - Glyco_hydro_88 SRD1_k127_674413_1 1341151.ASZU01000009_gene929 2.301e-13 72.0 COG0363@1|root,COG0363@2|Bacteria,1V1UT@1239|Firmicutes,4HFPX@91061|Bacilli,27CHK@186824|Thermoactinomycetaceae 91061|Bacilli G Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase - - 3.5.99.6 ko:K02564 ko00520,ko01100,map00520,map01100 - R00765 RC00163 ko00000,ko00001,ko01000 - - - Glucosamine_iso SRD1_k127_6760144_1 351160.LRC339 6.16e-76 282.0 COG3920@1|root,arCOG02335@2157|Archaea,2Y7UT@28890|Euryarchaeota,2NBMR@224756|Methanomicrobia 224756|Methanomicrobia T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA_2 SRD1_k127_6760144_3 1173029.JH980292_gene3313 2.027e-32 146.0 COG5001@1|root,COG5001@2|Bacteria,1G0SY@1117|Cyanobacteria,1H7V4@1150|Oscillatoriales 1117|Cyanobacteria T signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - - - - - - - - - - - EAL,GAF_2,GGDEF,PAS,PAS_3,PAS_4,PAS_9,Response_reg SRD1_k127_6760144_4 290315.Clim_0438 6.238e-12 76.0 COG1583@1|root,COG1583@2|Bacteria,1FDSA@1090|Chlorobi 1090|Chlorobi L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA) - - - ko:K19091 - - - - ko00000,ko01000,ko02048 - - - Cas_Cas6 SRD1_k127_6760144_0 1089550.ATTH01000001_gene1511 1.539e-82 292.0 COG0111@1|root,COG0111@2|Bacteria,4NGEB@976|Bacteroidetes,1FIM2@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes H Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate pdxB - 1.1.1.290 ko:K03473 ko00750,ko01100,map00750,map01100 M00124 R04210 RC00084 ko00000,ko00001,ko00002,ko01000 - - - 2-Hacid_dh,2-Hacid_dh_C,DUF3410 SRD1_k127_6760144_2 1500894.JQNN01000001_gene362 2.012e-54 202.0 COG2374@1|root,COG4935@1|root,COG2374@2|Bacteria,COG4935@2|Bacteria,1MX52@1224|Proteobacteria,2VK7U@28216|Betaproteobacteria 28216|Betaproteobacteria O endonuclease exonuclease phosphatase - - - ko:K07004 - - - - ko00000 - - - Exo_endo_phos,LTD SRD1_k127_6760653_4 1193181.BN10_50002 2.169e-05 57.0 COG4412@1|root,COG4412@2|Bacteria,2GMKQ@201174|Actinobacteria 201174|Actinobacteria M PFAM peptidase M6, immune inhibitor A - - - - - - - - - - - - Peptidase_M6 SRD1_k127_6760653_3 443144.GM21_3071 4.674e-06 53.0 COG3170@1|root,COG3170@2|Bacteria 2|Bacteria NU translation initiation factor activity - - 2.4.1.12 ko:K00694 ko00500,ko01100,ko02026,map00500,map01100,map02026 - R02889 RC00005 ko00000,ko00001,ko01000,ko01003,ko02000 4.D.3.1.2,4.D.3.1.5,4.D.3.1.6 GT2 - Beta_helix,Cellulose_synt,DUF3131,Glycos_transf_2 SRD1_k127_6760653_1 1191523.MROS_2067 2.396e-28 126.0 28PUG@1|root,2ZCFG@2|Bacteria 2|Bacteria S Protein of unknown function (DUF1207) - - - - - - - - - - - - DUF1207 SRD1_k127_6760653_0 204669.Acid345_1412 5.748e-51 184.0 COG2316@1|root,COG2316@2|Bacteria,3Y4GI@57723|Acidobacteria,2JJBG@204432|Acidobacteriia 204432|Acidobacteriia S Metal dependent phosphohydrolases with conserved 'HD' motif. - - - - - - - - - - - - HD SRD1_k127_681373_0 768710.DesyoDRAFT_3085 8.11e-81 278.0 COG1167@1|root,COG1167@2|Bacteria,1TPS5@1239|Firmicutes,248ZB@186801|Clostridia 186801|Clostridia K aminotransferase class I and II - - - - - - - - - - - - Aminotran_1_2,GntR SRD1_k127_681373_1 1519464.HY22_04545 7.716e-41 174.0 COG4447@1|root,COG4447@2|Bacteria 2|Bacteria S cellulose binding - - - - - - - - - - - - Big_2,PSII_BNR,fn3 SRD1_k127_682942_5 555088.DealDRAFT_0941 4.237e-32 132.0 COG1449@1|root,COG1449@2|Bacteria 2|Bacteria G Belongs to the glycosyl hydrolase 57 family amyA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.4.1.25 ko:K22451 ko00500,map00500 - R05196 RC00049 ko00000,ko00001,ko01000 - GH57 - DUF1925,DUF1926,Glyco_hydro_57 SRD1_k127_682942_3 258533.BN977_02710 6.795e-43 166.0 COG1215@1|root,COG1215@2|Bacteria,2HNME@201174|Actinobacteria,2351N@1762|Mycobacteriaceae 201174|Actinobacteria M Glycosyltransferase like family 2 - - - - - - - - - - - - Glycos_transf_2 SRD1_k127_682942_0 945713.IALB_1562 1.748e-176 568.0 COG0793@1|root,COG0793@2|Bacteria 2|Bacteria M Belongs to the peptidase S41A family ctp - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ_2,Peptidase_S41 SRD1_k127_682942_2 945713.IALB_1563 6.582e-46 176.0 2ETT1@1|root,33MAE@2|Bacteria 2|Bacteria S Protein of unknown function (DUF3108) - - - - - - - - - - - - DUF3108 SRD1_k127_682942_1 1087481.AGFX01000011_gene4111 6.802e-48 177.0 COG0663@1|root,COG0663@2|Bacteria,1V6CZ@1239|Firmicutes,4HFPC@91061|Bacilli,26X34@186822|Paenibacillaceae 91061|Bacilli S COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily ytoA - - - - - - - - - - - Hexapep SRD1_k127_682942_4 292564.Cyagr_2281 4.003e-41 156.0 COG1235@1|root,COG2199@1|root,COG2203@1|root,COG1235@2|Bacteria,COG2203@2|Bacteria,COG3706@2|Bacteria,1G1UR@1117|Cyanobacteria,22TIW@167375|Cyanobium 1117|Cyanobacteria T Beta-lactamase superfamily domain - - 3.1.26.11 ko:K00784 ko03013,map03013 - - - ko00000,ko00001,ko01000,ko03016 - - - Lactamase_B_2 SRD1_k127_6836427_2 1239962.C943_01339 0.00017 55.0 COG3866@1|root,COG4254@1|root,COG5492@1|root,COG3866@2|Bacteria,COG4254@2|Bacteria,COG5492@2|Bacteria 2|Bacteria N domain, Protein pel3 - - - - - - - - - - - FecR,Pectinesterase SRD1_k127_6836427_1 1519464.HY22_00625 3.598e-06 61.0 COG3210@1|root,COG3210@2|Bacteria 2|Bacteria U domain, Protein - - - ko:K15125 ko05133,map05133 - - - ko00000,ko00001,ko00536 - - - Beta_helix,DUF11,HemolysinCabind,PT-VENN SRD1_k127_6836427_0 864702.OsccyDRAFT_1188 1.673e-162 518.0 COG2183@1|root,COG2183@2|Bacteria,1G12X@1117|Cyanobacteria,1H7FA@1150|Oscillatoriales 1117|Cyanobacteria K Transcriptional accessory protein - - - ko:K06959 - - - - ko00000 - - - HHH_3,S1,Tex_N,Tex_YqgF SRD1_k127_6839134_0 869213.JCM21142_62446 4.463e-117 392.0 COG4677@1|root,COG4733@1|root,COG4677@2|Bacteria,COG4733@2|Bacteria,4NEEI@976|Bacteroidetes,47M0T@768503|Cytophagia 976|Bacteroidetes G Pectinesterase - - 3.1.1.11 ko:K01051 ko00040,ko01100,map00040,map01100 M00081 R02362 RC00460,RC00461 ko00000,ko00001,ko00002,ko01000 - - - Pectinesterase SRD1_k127_6839134_1 450851.PHZ_c2461 1.424e-11 68.0 COG5434@1|root,COG5434@2|Bacteria,1MXP8@1224|Proteobacteria,2TVCM@28211|Alphaproteobacteria,2KHU2@204458|Caulobacterales 204458|Caulobacterales G Belongs to the glycosyl hydrolase 28 family - - - - - - - - - - - - Glyco_hydro_28 SRD1_k127_6851614_1 1095769.CAHF01000005_gene1456 3.606e-118 392.0 COG0154@1|root,COG0154@2|Bacteria,1MW3Z@1224|Proteobacteria,2VJFS@28216|Betaproteobacteria 28216|Betaproteobacteria J Amidase - - 3.5.1.4 ko:K01426 ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120 - R02540,R03096,R03180,R03909,R05551,R05590 RC00010,RC00100,RC00950,RC01025 ko00000,ko00001,ko01000 - - - Amidase SRD1_k127_6851614_0 1237149.C900_05550 3.275e-254 799.0 COG1506@1|root,COG1506@2|Bacteria,4NETS@976|Bacteroidetes,47KF8@768503|Cytophagia 976|Bacteroidetes EU Dipeptidyl peptidase IV (DPP IV) N-terminal region - - 3.4.14.5 ko:K01278 ko04974,map04974 - - - ko00000,ko00001,ko01000,ko01002,ko04090,ko04147 - - - DPPIV_N,Peptidase_S9 SRD1_k127_6854284_1 661478.OP10G_0240 1.453e-67 244.0 COG1626@1|root,COG1626@2|Bacteria 2|Bacteria G alpha,alpha-trehalase activity ygjK GO:0003674,GO:0003824,GO:0004553,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0015926,GO:0016787,GO:0016798,GO:0033554,GO:0050896,GO:0051716 3.2.1.28 ko:K01194,ko:K03931 ko00500,ko01100,map00500,map01100 - R00010 RC00049 ko00000,ko00001,ko00537,ko01000 - GH37,GH63 - Glyco_hydro_63,Trehalase SRD1_k127_6854284_0 945713.IALB_0605 7.267e-75 266.0 COG0520@1|root,COG0520@2|Bacteria 2|Bacteria E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine - - - - - - - - - - - - Aminotran_5 SRD1_k127_687101_0 1191523.MROS_0092 4.421e-262 827.0 COG0247@1|root,COG1139@1|root,COG0247@2|Bacteria,COG1139@2|Bacteria 2|Bacteria C lactate oxidation lutB - - ko:K00782,ko:K18929 - - - - ko00000 - - - CCG,DUF3390,Fer4_8,LUD_dom SRD1_k127_6882777_1 443143.GM18_3447 7.636e-70 248.0 COG2027@1|root,COG2027@2|Bacteria,1MW40@1224|Proteobacteria,42R96@68525|delta/epsilon subdivisions,2WMVV@28221|Deltaproteobacteria 28221|Deltaproteobacteria M D-alanyl-D-alanine carboxypeptidase dacB - 3.4.16.4 ko:K07259 ko00550,map00550 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - Peptidase_S13 SRD1_k127_6882777_0 573370.DMR_25740 2.054e-172 558.0 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,42M4Z@68525|delta/epsilon subdivisions,2WJ0D@28221|Deltaproteobacteria,2M88M@213115|Desulfovibrionales 28221|Deltaproteobacteria O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 SRD1_k127_6904986_2 269799.Gmet_2862 9.014e-63 220.0 COG0171@1|root,COG0171@2|Bacteria,1MU9U@1224|Proteobacteria,42N86@68525|delta/epsilon subdivisions,2WIV4@28221|Deltaproteobacteria,43VVZ@69541|Desulfuromonadales 28221|Deltaproteobacteria H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source nadE - 6.3.1.5 ko:K01916 ko00760,ko01100,map00760,map01100 M00115 R00189 RC00100 ko00000,ko00001,ko00002,ko01000 - - - NAD_synthase SRD1_k127_6904986_1 945713.IALB_0461 1.116e-103 360.0 COG1404@1|root,COG1404@2|Bacteria 2|Bacteria O Belongs to the peptidase S8 family aprN - - - - - - - - - - - Peptidase_S8 SRD1_k127_6904986_4 1191523.MROS_0520 3.577e-08 66.0 COG2911@1|root,COG2911@2|Bacteria 2|Bacteria S protein secretion - - - ko:K15125 ko05133,map05133 - - - ko00000,ko00001,ko00536 - - - Porin_2 SRD1_k127_6904986_0 1121930.AQXG01000002_gene2256 1.405e-163 528.0 COG0160@1|root,COG0160@2|Bacteria,4NGPB@976|Bacteroidetes,1IP2R@117747|Sphingobacteriia 976|Bacteroidetes E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family lat - 2.6.1.36 ko:K03918 ko01100,map01100 - R00457 RC00006,RC00062 ko00000,ko01000,ko01007 - - - Aminotran_3 SRD1_k127_6904986_3 1089550.ATTH01000001_gene676 5.286e-28 113.0 COG1012@1|root,COG1012@2|Bacteria,4NEB7@976|Bacteroidetes,1FINT@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes C Belongs to the aldehyde dehydrogenase family mmsA - 1.2.1.18,1.2.1.27 ko:K00140,ko:K22187 ko00040,ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00040,map00280,map00410,map00562,map00640,map01100,map01200 M00013 R00705,R00706,R00922,R00935,R11768 RC00004,RC00080,RC02723,RC02817 ko00000,ko00001,ko00002,ko01000 - - - Aldedh SRD1_k127_6908217_1 247490.KSU1_C0017 2.679e-77 268.0 COG2890@1|root,COG2890@2|Bacteria 2|Bacteria J protein-(glutamine-N5) methyltransferase activity - - - - - - - - - - - - Methyltransf_12,Methyltransf_25,Methyltransf_31,rRNA_methylase SRD1_k127_6908217_3 401526.TcarDRAFT_1413 8.371e-60 215.0 COG1207@1|root,COG1207@2|Bacteria,1TP88@1239|Firmicutes,4H30V@909932|Negativicutes 909932|Negativicutes M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain glmU - 2.3.1.157,2.7.7.23 ko:K04042 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00362 R00416,R05332 RC00002,RC00004,RC00166 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transf_3,NTP_transferase SRD1_k127_6908217_0 517418.Ctha_0033 6.484e-85 290.0 COG0414@1|root,COG0414@2|Bacteria,1FDVQ@1090|Chlorobi 1090|Chlorobi H Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate panC - 6.3.2.1 ko:K01918 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R02473 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_ligase SRD1_k127_6908217_2 1121904.ARBP01000006_gene4014 8.086e-62 215.0 COG0777@1|root,COG0777@2|Bacteria,4NFMH@976|Bacteroidetes,47JX2@768503|Cytophagia 976|Bacteroidetes I Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA accD - 2.1.3.15,6.4.1.2 ko:K01963 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans SRD1_k127_6944158_2 247490.KSU1_A0047 3.082e-38 153.0 COG1331@1|root,COG1331@2|Bacteria 2|Bacteria O Highly conserved protein containing a thioredoxin domain - - - - - - - - - - - - DUF4861,Glyco_hydro_76 SRD1_k127_6944158_0 247490.KSU1_A0037 1.901e-241 768.0 COG0367@1|root,COG0367@2|Bacteria,2IXAI@203682|Planctomycetes 203682|Planctomycetes E Asparagine synthase, glutamine-hydrolyzing - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 SRD1_k127_6944158_1 479434.Sthe_1134 4.799e-63 221.0 COG1004@1|root,COG1004@2|Bacteria,2G62F@200795|Chloroflexi,27XRP@189775|Thermomicrobia 2|Bacteria C Belongs to the UDP-glucose GDP-mannose dehydrogenase family algD - 1.1.1.132,1.1.1.22 ko:K00012,ko:K00066 ko00040,ko00051,ko00053,ko00520,ko01100,ko02020,map00040,map00051,map00053,map00520,map01100,map02020 M00014,M00129,M00361,M00362 R00286,R00880 RC00291 ko00000,ko00001,ko00002,ko01000 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N SRD1_k127_696055_1 945713.IALB_1599 2.178e-103 351.0 COG2885@1|root,COG3637@1|root,COG2885@2|Bacteria,COG3637@2|Bacteria 2|Bacteria M Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - ko:K03286 - - - - ko00000,ko02000 1.B.6 - - OMP_b-brl,OmpA,TSP_3 SRD1_k127_696055_2 945713.IALB_2094 1.274e-60 216.0 COG0688@1|root,COG0688@2|Bacteria 2|Bacteria I phosphatidylethanolamine metabolic process psd - 4.1.1.65 ko:K01613 ko00564,ko01100,ko01110,map00564,map01100,map01110 M00093 R02055 RC00299 ko00000,ko00001,ko00002,ko01000 - - - PS_Dcarbxylase SRD1_k127_696055_3 945713.IALB_2095 1.882e-57 209.0 COG1183@1|root,COG1183@2|Bacteria 2|Bacteria I phosphatidylcholine synthase activity pssA - 2.7.8.8 ko:K17103 ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110 M00093 R01800 RC00002,RC00017,RC02795 ko00000,ko00001,ko00002,ko01000 - - - CDP-OH_P_transf SRD1_k127_696055_5 1519464.HY22_12795 1.84e-21 96.0 COG1828@1|root,COG1828@2|Bacteria 2|Bacteria F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purS - 6.3.2.6,6.3.5.3 ko:K01923,ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463,R04591 RC00010,RC00064,RC00162,RC01160 ko00000,ko00001,ko00002,ko01000 - - iYO844.BSU06460 PurS SRD1_k127_696055_0 518766.Rmar_2306 1.047e-103 343.0 COG0047@1|root,COG0047@2|Bacteria,4NFER@976|Bacteroidetes,1FIWZ@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purQ - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - GATase_5 SRD1_k127_696055_6 518766.Rmar_2500 1.108e-13 72.0 COG1826@1|root,COG1826@2|Bacteria,4PETH@976|Bacteroidetes,1FJKH@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system tatA - - ko:K03116 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - MttA_Hcf106 SRD1_k127_696055_7 1121377.KB906398_gene2025 8.448e-12 66.0 COG1826@1|root,COG1826@2|Bacteria,1WKBC@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system - - - ko:K03116 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - MttA_Hcf106 SRD1_k127_696055_4 518766.Rmar_2499 7.037e-45 167.0 COG0154@1|root,COG0154@2|Bacteria,4NF8C@976|Bacteroidetes,1FJ4U@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) gatA - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase SRD1_k127_6960997_1 497965.Cyan7822_4946 2.361e-101 337.0 COG2321@1|root,COG2321@2|Bacteria,1G9J1@1117|Cyanobacteria,3KJ07@43988|Cyanothece 1117|Cyanobacteria S Putative neutral zinc metallopeptidase - - - ko:K07054 - - - - ko00000 - - - Zn_peptidase SRD1_k127_6960997_0 365046.Rta_05130 2.878e-283 888.0 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,2VHEV@28216|Betaproteobacteria,4AAU8@80864|Comamonadaceae 1224|Proteobacteria O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins - - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 SRD1_k127_6972965_2 290317.Cpha266_0490 2.809e-83 282.0 COG0543@1|root,COG0543@2|Bacteria,1FDJ4@1090|Chlorobi 1090|Chlorobi C PFAM oxidoreductase FAD NAD(P)-binding domain protein - - 1.18.1.2,1.19.1.1 ko:K00528 - - R10159 - ko00000,ko01000 - - - DHODB_Fe-S_bind,NAD_binding_1 SRD1_k127_6972965_1 880073.Calab_2036 5.776e-166 536.0 COG0493@1|root,COG0493@2|Bacteria,2NNXN@2323|unclassified Bacteria 2|Bacteria E Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster gltA - 1.4.1.13,1.4.1.14 ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - DHODB_Fe-S_bind,Fer4_20,NAD_binding_1,Pyr_redox_2 SRD1_k127_6972965_5 1379698.RBG1_1C00001G0157 8.957e-52 200.0 COG0642@1|root,COG2205@2|Bacteria 1379698.RBG1_1C00001G0157|- T PhoQ Sensor - - - - - - - - - - - - - SRD1_k127_6972965_6 945713.IALB_2520 1.411e-51 194.0 COG1639@1|root,COG1639@2|Bacteria 2|Bacteria T HDOD domain - - - - - - - - - - - - HDOD SRD1_k127_6972965_8 645991.Sgly_0607 8.401e-09 60.0 COG1987@1|root,COG1987@2|Bacteria,1VEHF@1239|Firmicutes,24QJR@186801|Clostridia,262CY@186807|Peptococcaceae 186801|Clostridia N Role in flagellar biosynthesis fliQ - - ko:K02420 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - Bac_export_3 SRD1_k127_6972965_4 583355.Caka_1913 3.465e-52 191.0 COG2199@1|root,COG3706@2|Bacteria,46ST0@74201|Verrucomicrobia,3K80V@414999|Opitutae 414999|Opitutae T cheY-homologous receiver domain - - - - - - - - - - - - Response_reg SRD1_k127_6972965_7 1306174.JODP01000013_gene7620 6.722e-39 157.0 COG5002@1|root,COG5002@2|Bacteria,2I2TP@201174|Actinobacteria 201174|Actinobacteria T Histidine kinase - - - - - - - - - - - - CHASE3,GAF_2,HATPase_c,HisKA,Hpt,PAS,PAS_4,PAS_9,Response_reg,dCache_1 SRD1_k127_6972965_3 583355.Caka_1913 3.986e-55 198.0 COG2199@1|root,COG3706@2|Bacteria,46ST0@74201|Verrucomicrobia,3K80V@414999|Opitutae 414999|Opitutae T cheY-homologous receiver domain - - - - - - - - - - - - Response_reg SRD1_k127_6972965_0 497964.CfE428DRAFT_0230 3.108e-166 543.0 COG0642@1|root,COG5002@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,46TGZ@74201|Verrucomicrobia 74201|Verrucomicrobia T histidine kinase A domain protein - - - - - - - - - - - - HATPase_c,HisKA,Response_reg SRD1_k127_697666_2 243231.GSU2261 3.247e-92 317.0 COG0763@1|root,COG0763@2|Bacteria,1MVBI@1224|Proteobacteria,42P35@68525|delta/epsilon subdivisions,2WJFA@28221|Deltaproteobacteria,43SZS@69541|Desulfuromonadales 28221|Deltaproteobacteria M Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxB GO:0003674,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0019637,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.4.1.182 ko:K00748 ko00540,ko01100,map00540,map01100 M00060 R04606 RC00005,RC00059 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT19 - LpxB SRD1_k127_697666_6 1151292.QEW_0306 0.0007723 51.0 COG1729@1|root,COG1729@2|Bacteria,1VDE3@1239|Firmicutes,25EWU@186801|Clostridia,25QQS@186804|Peptostreptococcaceae 186801|Clostridia S Tetratricopeptide repeat - - - - - - - - - - - - TPR_6,TPR_8 SRD1_k127_697666_3 290397.Adeh_2613 1.623e-57 213.0 COG1663@1|root,COG1663@2|Bacteria,1MU8G@1224|Proteobacteria,42PA2@68525|delta/epsilon subdivisions,2WNJ4@28221|Deltaproteobacteria 28221|Deltaproteobacteria F Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) lpxK - 2.7.1.130 ko:K00912 ko00540,ko01100,map00540,map01100 M00060 R04657 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko01005 - - - LpxK SRD1_k127_697666_5 743722.Sph21_0664 4.198e-45 177.0 COG2071@1|root,COG2071@2|Bacteria,4NNEJ@976|Bacteroidetes,1IS4X@117747|Sphingobacteriia 976|Bacteroidetes S Peptidase C26 - - - ko:K07010 - - - - ko00000,ko01002 - - - Peptidase_C26 SRD1_k127_697666_0 1499967.BAYZ01000088_gene5125 0.0 1317.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2NNNY@2323|unclassified Bacteria 2|Bacteria G Belongs to the PEP-utilizing enzyme family ppdK - 2.7.9.1 ko:K01006 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N SRD1_k127_697666_1 1191523.MROS_1834 2.476e-157 504.0 COG0809@1|root,COG0809@2|Bacteria 2|Bacteria J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) queA - 2.4.99.17 ko:K07568 - - - - ko00000,ko01000,ko03016 - - - Queuosine_synth SRD1_k127_697666_4 706587.Desti_0382 1.883e-54 195.0 COG0531@1|root,COG0531@2|Bacteria,1R829@1224|Proteobacteria,42MS5@68525|delta/epsilon subdivisions,2WINQ@28221|Deltaproteobacteria,2MSEM@213462|Syntrophobacterales 28221|Deltaproteobacteria E Amino acid permease - - - - - - - - - - - - AA_permease_2 SRD1_k127_6988782_1 502025.Hoch_6665 1.38e-147 482.0 COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,42NYP@68525|delta/epsilon subdivisions,2WIPJ@28221|Deltaproteobacteria,2YXKT@29|Myxococcales 28221|Deltaproteobacteria S Insulinase (Peptidase family M16) - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C SRD1_k127_6988782_0 234267.Acid_4726 2.468e-148 479.0 COG0308@1|root,COG0308@2|Bacteria,3Y3ZS@57723|Acidobacteria 57723|Acidobacteria E Phospholipase B - - - - - - - - - - - - Phospholip_B SRD1_k127_6989176_2 1267535.KB906767_gene3348 8.14e-117 381.0 COG1012@1|root,COG1012@2|Bacteria,3Y37W@57723|Acidobacteria,2JHJP@204432|Acidobacteriia 204432|Acidobacteriia C Delta-1-pyrroline-5-carboxylate dehydrogenase - - 1.2.1.88 ko:K00294 ko00250,ko00330,ko01100,map00250,map00330,map01100 - R00245,R00707,R00708,R04444,R04445,R05051 RC00080,RC00216,RC00242,RC00255 ko00000,ko00001,ko01000 - - - Aldedh SRD1_k127_6989176_0 880073.Calab_0629 6.214e-172 551.0 COG0045@1|root,COG0045@2|Bacteria,2NNQA@2323|unclassified Bacteria 2|Bacteria F Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit sucC - 6.2.1.5 ko:K01903 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_2,Ligase_CoA SRD1_k127_6989176_1 1191523.MROS_1702 5.55e-169 539.0 COG0064@1|root,COG0064@2|Bacteria 2|Bacteria J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatB GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.1.1.12,6.3.5.6,6.3.5.7 ko:K01876,ko:K02434 ko00970,ko01100,map00970,map01100 M00359,M00360 R03905,R04212,R05577 RC00010,RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - GatB_N,GatB_Yqey SRD1_k127_6995927_0 526218.Sterm_0793 2.223e-175 566.0 COG0493@1|root,COG0543@1|root,COG0493@2|Bacteria,COG0543@2|Bacteria,37934@32066|Fusobacteria 32066|Fusobacteria C FAD-dependent pyridine nucleotide-disulphide oxidoreductase gltA - 1.4.1.13,1.4.1.14 ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - DHODB_Fe-S_bind,Fer4_20,NAD_binding_1,Pyr_redox_2 SRD1_k127_701852_1 1210884.HG799462_gene7872 1.768e-46 178.0 COG0095@1|root,COG0095@2|Bacteria,2J0D8@203682|Planctomycetes 203682|Planctomycetes H PFAM Biotin lipoate A B protein ligase - - 6.3.1.20 ko:K03800 ko00785,ko01100,map00785,map01100 - R07770,R07771,R11143 RC00043,RC00070,RC00090,RC00992,RC02896 ko00000,ko00001,ko01000 - - - BPL_LplA_LipB SRD1_k127_701852_0 314230.DSM3645_06639 0.0 1092.0 COG2609@1|root,COG2609@2|Bacteria,2IXXY@203682|Planctomycetes 203682|Planctomycetes C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) aceE - 1.2.4.1 ko:K00163 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transketolase_N SRD1_k127_7018813_0 289376.THEYE_A1135 1.614e-105 368.0 COG2887@1|root,COG2887@2|Bacteria 2|Bacteria L Belongs to the helicase family. UvrD subfamily - - - - - - - - - - - - AAA_24,PDDEXK_1 SRD1_k127_7018813_1 289376.THEYE_A1137 3.678e-48 188.0 COG1074@1|root,COG1074@2|Bacteria,3J16M@40117|Nitrospirae 40117|Nitrospirae L PD-(D/E)XK nuclease superfamily - - - - - - - - - - - - PDDEXK_1,UvrD-helicase,UvrD_C SRD1_k127_703035_2 945713.IALB_2347 3.364e-47 177.0 COG3292@1|root,COG3292@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - Reg_prop SRD1_k127_703035_4 1313301.AUGC01000007_gene619 3.887e-24 106.0 2ASD9@1|root,31HSR@2|Bacteria,4NQ71@976|Bacteroidetes 976|Bacteroidetes S DNA-binding protein - - - - - - - - - - - - DUF3276 SRD1_k127_703035_3 1191523.MROS_2448 3.967e-29 127.0 COG1399@1|root,COG1399@2|Bacteria 2|Bacteria K metal-binding, possibly nucleic acid-binding protein yceD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 - ko:K07040 - - - - ko00000 - - - DUF177 SRD1_k127_703035_5 1382359.JIAL01000001_gene525 6.893e-19 89.0 COG0333@1|root,COG0333@2|Bacteria,3Y5HY@57723|Acidobacteria,2JJZ9@204432|Acidobacteriia 204432|Acidobacteriia J Ribosomal L32p protein family rpmF - - ko:K02911 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_L32p SRD1_k127_703035_0 945713.IALB_1994 5.561e-94 320.0 COG0416@1|root,COG0416@2|Bacteria 2|Bacteria I fatty acid biosynthetic process plsX - 2.3.1.15 ko:K03621 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FA_synthesis SRD1_k127_703035_1 1191523.MROS_2451 5.215e-74 257.0 COG0332@1|root,COG0332@2|Bacteria 2|Bacteria I beta-ketoacyl-acyl-carrier-protein synthase III activity fabH GO:0003674,GO:0003824,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0033818,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0071704 2.3.1.180 ko:K00648 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00082,M00083 R10707 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACP_syn_III,ACP_syn_III_C SRD1_k127_70341_2 1140.Synpcc7942_2573 1.722e-17 93.0 COG1108@1|root,COG1108@2|Bacteria,1G17S@1117|Cyanobacteria,1GZDW@1129|Synechococcus 1117|Cyanobacteria P COG1108 ABC-type Mn2 Zn2 transport systems, permease components mntB - - ko:K09819,ko:K11602 ko02010,ko02020,map02010,map02020 M00243,M00316 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15,3.A.1.15.1 - - ABC-3 SRD1_k127_70341_0 237368.SCABRO_03161 9.909e-63 224.0 COG1121@1|root,COG1121@2|Bacteria,2IYC3@203682|Planctomycetes 203682|Planctomycetes P COG1121 ABC-type Mn Zn transport systems ATPase component - - - ko:K11607,ko:K11710 ko02010,map02010 M00317,M00319 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15,3.A.1.15.7,3.A.1.15.9 - - ABC_tran SRD1_k127_70341_1 1379698.RBG1_1C00001G0108 1.654e-46 173.0 COG0803@1|root,COG0803@2|Bacteria,2NPH3@2323|unclassified Bacteria 2|Bacteria P Belongs to the bacterial solute-binding protein 9 family znuA - - ko:K02077,ko:K09815,ko:K09818 ko02010,map02010 M00242,M00243,M00244 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15,3.A.1.15.3,3.A.1.15.5 - - ZnuA SRD1_k127_7046394_3 1267533.KB906734_gene4312 5.329e-05 50.0 COG0673@1|root,COG0673@2|Bacteria,3Y33K@57723|Acidobacteria,2JHRX@204432|Acidobacteriia 204432|Acidobacteriia S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C SRD1_k127_7046394_1 1128421.JAGA01000003_gene2817 2.75e-73 254.0 COG0596@1|root,COG0596@2|Bacteria,2NQV9@2323|unclassified Bacteria 2|Bacteria S Alpha/beta hydrolase family ybfF GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016787,GO:0016788,GO:0016790,GO:0044424,GO:0044444,GO:0044464,GO:0052689 - ko:K01175 - - - - ko00000,ko01000 - - - Abhydrolase_1,Abhydrolase_6 SRD1_k127_7046394_0 1121904.ARBP01000004_gene812 1.462e-99 344.0 COG0642@1|root,COG2205@2|Bacteria,4NUBB@976|Bacteroidetes 976|Bacteroidetes T GHKL domain - - - - - - - - - - - - HATPase_c,HisKA SRD1_k127_7046394_2 945713.IALB_2695 3.73e-16 80.0 COG0745@1|root,COG0745@2|Bacteria 945713.IALB_2695|- T phosphorelay signal transduction system - - - - - - - - - - - - - SRD1_k127_705377_6 1242864.D187_010298 0.0005459 48.0 COG2374@1|root,COG5434@1|root,COG2374@2|Bacteria,COG5434@2|Bacteria 2|Bacteria M polygalacturonase activity - - - - - - - - - - - - Amidohydro_1,Beta_helix,Big_2,Big_5,CBM_35,DUF4215,Exo_endo_phos,Flg_new,Glyco_hydro_43,LTD,Laminin_G_3,RicinB_lectin_2,SLH,TSP_3,fn3 SRD1_k127_705377_5 745718.JADT01000001_gene1556 8.409e-26 112.0 COG1652@1|root,COG1652@2|Bacteria,4NNRS@976|Bacteroidetes,1I1Y9@117743|Flavobacteriia 976|Bacteroidetes S LysM domain - - - - - - - - - - - - LysM SRD1_k127_705377_4 1158292.JPOE01000002_gene3200 9.296e-29 119.0 COG3753@1|root,COG3753@2|Bacteria,1N7FF@1224|Proteobacteria,2VVTK@28216|Betaproteobacteria,1KMJG@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Bacterial protein of unknown function (DUF937) - - - - - - - - - - - - DUF937 SRD1_k127_705377_3 56110.Oscil6304_1399 1.114e-41 168.0 COG0642@1|root,COG0745@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,1G3R6@1117|Cyanobacteria,1HAGB@1150|Oscillatoriales 1117|Cyanobacteria T Response regulator receiver domain - - - - - - - - - - - - HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg SRD1_k127_705377_2 580332.Slit_1329 3.44e-51 186.0 COG0784@1|root,COG0784@2|Bacteria,1QUN7@1224|Proteobacteria,2WGQ0@28216|Betaproteobacteria 28216|Betaproteobacteria T response regulator - - - ko:K02485 - - - - ko00000,ko02022 - - - Response_reg SRD1_k127_705377_1 580332.Slit_1327 1.556e-78 275.0 COG2203@1|root,COG3829@1|root,COG4251@1|root,COG2203@2|Bacteria,COG3829@2|Bacteria,COG4251@2|Bacteria,1RGKE@1224|Proteobacteria,2WHFM@28216|Betaproteobacteria,44WPK@713636|Nitrosomonadales 28216|Betaproteobacteria T SMART ATP-binding region ATPase domain protein - - - - - - - - - - - - HATPase_c,HisKA,PAS_4 SRD1_k127_705377_0 296591.Bpro_3508 3.334e-84 289.0 COG3290@1|root,COG3290@2|Bacteria,1QXG8@1224|Proteobacteria 1224|Proteobacteria T PAS domain - - 3.1.3.3 ko:K07315 - - - - ko00000,ko01000,ko03021 - - - HD_5,MASE3,PAS,PAS_9 SRD1_k127_7059779_4 768670.Calni_0136 5.643e-32 126.0 COG0171@1|root,COG0171@2|Bacteria,2GEZC@200930|Deferribacteres 200930|Deferribacteres H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source nadE - 6.3.1.5 ko:K01916 ko00760,ko01100,map00760,map01100 M00115 R00189 RC00100 ko00000,ko00001,ko00002,ko01000 - - - NAD_synthase SRD1_k127_7059779_1 880073.Calab_1179 4.246e-70 248.0 COG0313@1|root,COG0313@2|Bacteria,2NP98@2323|unclassified Bacteria 2|Bacteria H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA rsmI GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0070677,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.198 ko:K07056 - - - - ko00000,ko01000,ko03009 - - - TP_methylase SRD1_k127_7059779_0 886293.Sinac_7048 6.491e-151 501.0 COG0366@1|root,COG0366@2|Bacteria,2J24X@203682|Planctomycetes 203682|Planctomycetes G PFAM Alpha amylase, catalytic - - - - - - - - - - - - Alpha-amylase SRD1_k127_7059779_2 945713.IALB_2178 3.688e-40 151.0 COG0234@1|root,COG0234@2|Bacteria 2|Bacteria O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter groS GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0010033,GO:0016032,GO:0016465,GO:0019058,GO:0019068,GO:0032991,GO:0035966,GO:0042221,GO:0042802,GO:0043167,GO:0043169,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051704,GO:0061077,GO:0101031,GO:1990220 - ko:K04078 - - - - ko00000,ko03029,ko03110 - - - Cpn10 SRD1_k127_7059779_3 861299.J421_3164 3.811e-38 145.0 COG0459@1|root,COG0459@2|Bacteria,1ZTC5@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions - - - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 SRD1_k127_7065309_0 744872.Spica_0291 2.273e-296 918.0 COG3459@1|root,COG3459@2|Bacteria,2J6AR@203691|Spirochaetes 203691|Spirochaetes G InterPro IPR009342 IPR010383 IPR010403 - - 2.4.1.280 ko:K18675 ko00520,map00520 - R09942 RC00049 ko00000,ko00001,ko01000 - GH94 - Glyco_hydro_36,Glyco_transf_36 SRD1_k127_7065309_2 159749.K0TD96 2.562e-68 247.0 COG3325@1|root,KOG2806@2759|Eukaryota,2XDZU@2836|Bacillariophyta 2836|Bacillariophyta G Glyco_18 - - - - - - - - - - - - Glyco_hydro_18 SRD1_k127_7065309_1 1349822.NSB1T_09395 3.069e-185 590.0 COG0477@1|root,COG2814@2|Bacteria,4NG5F@976|Bacteroidetes,2FP47@200643|Bacteroidia,231CE@171551|Porphyromonadaceae 976|Bacteroidetes EGP Major Facilitator Superfamily ampG - - ko:K08218 ko01501,map01501 M00628 - - ko00000,ko00001,ko00002,ko02000 2.A.1.25 - - MFS_1 SRD1_k127_7065309_3 1191523.MROS_0111 8.877e-37 148.0 COG0708@1|root,COG0708@2|Bacteria 2|Bacteria L double-stranded DNA 3'-5' exodeoxyribonuclease activity - - 3.1.11.2 ko:K01142 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Exo_endo_phos SRD1_k127_706544_0 404589.Anae109_0240 1.335e-239 756.0 COG0493@1|root,COG1145@1|root,COG0493@2|Bacteria,COG1145@2|Bacteria,1MU2H@1224|Proteobacteria,42MGY@68525|delta/epsilon subdivisions,2WKB4@28221|Deltaproteobacteria,2YTUD@29|Myxococcales 28221|Deltaproteobacteria C Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - 1.4.1.13,1.4.1.14 ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - Fer4,Fer4_20,Pyr_redox_2 SRD1_k127_706544_2 485918.Cpin_4401 2.113e-50 187.0 COG2755@1|root,COG2755@2|Bacteria,4NJGD@976|Bacteroidetes,1IU06@117747|Sphingobacteriia 976|Bacteroidetes E GDSL-like Lipase/Acylhydrolase family - - - - - - - - - - - - Lipase_GDSL_2 SRD1_k127_706544_3 290402.Cbei_4352 8.359e-19 98.0 COG0388@1|root,COG0388@2|Bacteria,1TQDK@1239|Firmicutes,24AWV@186801|Clostridia,36KEG@31979|Clostridiaceae 186801|Clostridia S PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase - - - - - - - - - - - - CN_hydrolase SRD1_k127_706544_1 452637.Oter_2893 2.626e-137 459.0 COG0591@1|root,COG0591@2|Bacteria,46UT3@74201|Verrucomicrobia,3K9PJ@414999|Opitutae 414999|Opitutae E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - - - - - - - - - - SSF SRD1_k127_7084095_0 247490.KSU1_C1626 1.373e-99 334.0 COG1966@1|root,COG1966@2|Bacteria,2IWZE@203682|Planctomycetes 203682|Planctomycetes T Carbon starvation protein cstA - - ko:K06200 - - - - ko00000 - - - CstA,CstA_5TM SRD1_k127_7084095_2 610130.Closa_2101 2.181e-25 109.0 COG0792@1|root,COG0792@2|Bacteria,1VFHQ@1239|Firmicutes,24QNK@186801|Clostridia,220VX@1506553|Lachnoclostridium 186801|Clostridia L Belongs to the UPF0102 family - - - ko:K07460 - - - - ko00000 - - - UPF0102 SRD1_k127_7084095_1 411474.COPEUT_00154 2.524e-55 199.0 COG0164@1|root,COG0164@2|Bacteria,1V1D6@1239|Firmicutes,248IT@186801|Clostridia 186801|Clostridia L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhB - 3.1.26.4 ko:K03470 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_HII SRD1_k127_7099034_5 696747.NIES39_K02130 7.684e-21 105.0 COG0457@1|root,COG0457@2|Bacteria,1G4DA@1117|Cyanobacteria,1HI8X@1150|Oscillatoriales 1117|Cyanobacteria S Tetratricopeptide repeat - - - - - - - - - - - - - SRD1_k127_7099034_3 760192.Halhy_0781 8.42e-35 138.0 COG0454@1|root,COG0456@2|Bacteria,4NURB@976|Bacteroidetes,1IU7H@117747|Sphingobacteriia 976|Bacteroidetes K DinB superfamily - - - - - - - - - - - - DinB_2 SRD1_k127_7099034_1 596151.DesfrDRAFT_0488 1.59e-48 186.0 COG0702@1|root,COG0702@2|Bacteria,1MW44@1224|Proteobacteria 1224|Proteobacteria GM NmrA family yesF - - - - - - - - - - - NAD_binding_10,NmrA SRD1_k127_7099034_6 240016.ABIZ01000001_gene2393 7.709e-11 66.0 2C4M3@1|root,2ZD1R@2|Bacteria,46WTA@74201|Verrucomicrobia 74201|Verrucomicrobia - - - - - ko:K13640 - - - - ko00000,ko03000 - - - MerR_2 SRD1_k127_7099034_0 1396418.BATQ01000125_gene5090 7.295e-114 376.0 COG0484@1|root,COG0484@2|Bacteria,46S6P@74201|Verrucomicrobia,2IV3Z@203494|Verrucomicrobiae 203494|Verrucomicrobiae O DnaJ molecular chaperone homology domain - - - - - - - - - - - - DnaJ,DnaJ_C SRD1_k127_7099034_4 292459.STH503 7.624e-27 118.0 COG0576@1|root,COG0576@2|Bacteria,1V6G2@1239|Firmicutes,24MQK@186801|Clostridia 186801|Clostridia O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ grpE - - ko:K03687 - - - - ko00000,ko03029,ko03110 - - - GrpE SRD1_k127_7099034_2 945713.IALB_0312 8.119e-47 171.0 COG1219@1|root,COG1219@2|Bacteria 2|Bacteria O unfolded protein binding clpX GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044238,GO:0051301,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 - ko:K03544 ko04112,map04112 - - - ko00000,ko00001,ko03110 - - - AAA_2,ClpB_D2-small,zf-C4_ClpX SRD1_k127_7100261_2 880073.Calab_3201 6.062e-153 511.0 COG4198@1|root,COG4198@2|Bacteria,2NNV0@2323|unclassified Bacteria 2|Bacteria S Protein of unknown function (DUF1015) gdh - 1.4.1.4 ko:K00262 ko00220,ko00250,ko00910,ko01100,map00220,map00250,map00910,map01100 - R00248 RC00006,RC02799 ko00000,ko00001,ko01000 - - - DUF1015 SRD1_k127_7100261_1 1304284.L21TH_0118 1.22e-153 493.0 COG0075@1|root,COG0075@2|Bacteria,1TPS0@1239|Firmicutes,24919@186801|Clostridia,36E72@31979|Clostridiaceae 186801|Clostridia E Aminotransferase - - - - - - - - - - - - Aminotran_5 SRD1_k127_7100261_0 926556.Echvi_0838 9.345e-165 543.0 COG1629@1|root,COG4771@2|Bacteria,4NF66@976|Bacteroidetes,47JMC@768503|Cytophagia 976|Bacteroidetes P Carboxypeptidase regulatory-like domain - - - - - - - - - - - - CarboxypepD_reg,Plug SRD1_k127_7116645_4 1379698.RBG1_1C00001G0607 3.336e-13 70.0 COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2NQNE@2323|unclassified Bacteria 2|Bacteria T Serine threonine protein kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PASTA,Pkinase,TPR_2,TPR_8 SRD1_k127_7116645_2 485913.Krac_5920 8.312e-151 490.0 COG0641@1|root,COG0641@2|Bacteria,2G74V@200795|Chloroflexi 200795|Chloroflexi C Iron-sulfur cluster-binding domain - - - ko:K06871 - - - - ko00000 - - - Radical_SAM,SPASM SRD1_k127_7116645_0 246200.SPO3286 1.296e-172 560.0 COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,2TTXG@28211|Alphaproteobacteria,4NBYM@97050|Ruegeria 28211|Alphaproteobacteria P Sulfatase atsA - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase SRD1_k127_7116645_3 1089551.KE386572_gene2551 1.893e-72 266.0 COG3119@1|root,COG3119@2|Bacteria,1MV0B@1224|Proteobacteria,2TRI6@28211|Alphaproteobacteria,4BRA8@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria P Sulfatase - - - - - - - - - - - - DUF4976,Sulfatase SRD1_k127_7116645_1 867845.KI911784_gene1189 4.512e-153 501.0 COG1086@1|root,COG1086@2|Bacteria,2G5M8@200795|Chloroflexi,376PG@32061|Chloroflexia 32061|Chloroflexia GM short-chain dehydrogenase reductase SDR - - - - - - - - - - - - CoA_binding_3,Polysacc_synt_2 SRD1_k127_7122384_2 383381.EH30_14475 0.0009424 46.0 2EDJ0@1|root,337EV@2|Bacteria,1N9QM@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - SRD1_k127_7122384_1 1536769.P40081_10840 9.139e-28 119.0 COG2363@1|root,COG2363@2|Bacteria,1VA79@1239|Firmicutes,4HKHG@91061|Bacilli,26Z1H@186822|Paenibacillaceae 91061|Bacilli S membrane ywdK - - - - - - - - - - - DUF423 SRD1_k127_7122384_0 290397.Adeh_3396 1.498e-202 653.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,42MHP@68525|delta/epsilon subdivisions,2WIQG@28221|Deltaproteobacteria,2YUFQ@29|Myxococcales 28221|Deltaproteobacteria H Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA acsA - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C SRD1_k127_7136884_0 717606.PaecuDRAFT_1824 9.203e-96 338.0 COG1470@1|root,COG3693@1|root,COG5434@1|root,COG1470@2|Bacteria,COG3693@2|Bacteria,COG5434@2|Bacteria,1UIPP@1239|Firmicutes,4ISP9@91061|Bacilli,2775K@186822|Paenibacillaceae 91061|Bacilli G PFAM glycoside hydrolase family 10 - - - - - - - - - - - - Cadherin-like,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N,Lipase_GDSL_2,Polysacc_deac_1,SLH SRD1_k127_7136884_1 2850.Phatr47966 1.337e-49 192.0 2CNWF@1|root,2QYCA@2759|Eukaryota,2XFZH@2836|Bacillariophyta 2836|Bacillariophyta S Glycosyltransferase WbsX - - - - - - - - - - - - Glyco_hydro_99 SRD1_k127_7136884_2 945713.IALB_3128 1.31e-07 54.0 COG3386@1|root,COG3386@2|Bacteria 2|Bacteria G gluconolactonase activity - - - - - - - - - - - - SGL SRD1_k127_7141186_1 1379698.RBG1_1C00001G0402 5.34e-198 642.0 COG1200@1|root,COG1200@2|Bacteria,2NNS3@2323|unclassified Bacteria 2|Bacteria L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) recG GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016020,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,RecG_wedge SRD1_k127_7141186_2 1379270.AUXF01000003_gene3811 2.906e-63 223.0 COG0586@1|root,COG0586@2|Bacteria,1ZTJB@142182|Gemmatimonadetes 142182|Gemmatimonadetes S SNARE associated Golgi protein - - - ko:K03975 - - - - ko00000 - - - SNARE_assoc SRD1_k127_7141186_0 194439.CT0923 9.181e-236 737.0 COG0531@1|root,COG0531@2|Bacteria,1FECX@1090|Chlorobi 1090|Chlorobi E C-terminus of AA_permease - - - ko:K03294 - - - - ko00000 2.A.3.2 - - AA_permease_2 SRD1_k127_7141186_3 485917.Phep_1002 2.194e-09 59.0 COG0531@1|root,COG0531@2|Bacteria,4NH7J@976|Bacteroidetes,1IPW4@117747|Sphingobacteriia 976|Bacteroidetes E amino acid - - - ko:K03294 - - - - ko00000 2.A.3.2 - - AA_permease_2 SRD1_k127_7150739_6 1121104.AQXH01000002_gene719 4.955e-05 49.0 COG0468@1|root,COG0468@2|Bacteria,4NEXT@976|Bacteroidetes,1INW2@117747|Sphingobacteriia 976|Bacteroidetes L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage recA - - ko:K03553 ko03440,map03440 M00729 - - ko00000,ko00001,ko00002,ko03400 - - - RecA SRD1_k127_7150739_3 1379698.RBG1_1C00001G1887 1.324e-35 143.0 COG1514@1|root,COG1514@2|Bacteria,2NPRT@2323|unclassified Bacteria 2|Bacteria J Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester ligT GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008104,GO:0008150,GO:0009966,GO:0010646,GO:0010738,GO:0023051,GO:0033036,GO:0034237,GO:0044424,GO:0044444,GO:0044464,GO:0048583,GO:0050789,GO:0050794,GO:0051018,GO:0051179,GO:0065007,GO:1902531 3.1.4.58 ko:K01975 - - - - ko00000,ko01000,ko03016 - - - LigT_PEase SRD1_k127_7150739_0 945713.IALB_1329 5.711e-111 373.0 COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria 2|Bacteria S nicotinamide-nucleotide amidase activity cinA - 3.5.1.42 ko:K03742,ko:K03743 ko00760,map00760 - R02322 RC00100 ko00000,ko00001,ko01000 - - - CinA,MoCF_biosynth SRD1_k127_7150739_4 290318.Cvib_0497 8.503e-27 117.0 COG1267@1|root,COG1267@2|Bacteria,1FE6P@1090|Chlorobi 1090|Chlorobi I PFAM phosphatidylglycerophosphatase A - - 3.1.3.27 ko:K01095 ko00564,ko01100,map00564,map01100 - R02029 RC00017 ko00000,ko00001,ko01000 - - - PgpA SRD1_k127_7150739_2 1191523.MROS_2432 4.608e-54 196.0 COG0558@1|root,COG0558@2|Bacteria 2|Bacteria I Belongs to the CDP-alcohol phosphatidyltransferase class-I family pgsA GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008444,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0030312,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0071944,GO:0090407,GO:1901576 2.7.8.41,2.7.8.5 ko:K00995,ko:K08744 ko00564,ko01100,map00564,map01100 - R01801,R02030 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 - - iIT341.HP1016,iJN678.pgsA,iSB619.SA_RS06365 CDP-OH_P_transf SRD1_k127_7150739_5 469371.Tbis_2786 8.093e-19 90.0 COG0227@1|root,COG0227@2|Bacteria,2GQNU@201174|Actinobacteria,4E758@85010|Pseudonocardiales 201174|Actinobacteria J Belongs to the bacterial ribosomal protein bL28 family rpmB GO:0003674,GO:0003735,GO:0005198 - ko:K02902 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L28 SRD1_k127_7150739_1 518766.Rmar_2266 5.619e-83 282.0 COG0533@1|root,COG0533@2|Bacteria,4NE8E@976|Bacteroidetes,1FIMF@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction tsaD GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360 2.3.1.234 ko:K01409 - - R10648 RC00070,RC00416 ko00000,ko01000,ko03016 - - - Peptidase_M22 SRD1_k127_71514_0 1519464.HY22_13125 1.759e-151 500.0 COG0737@1|root,COG1520@1|root,COG0737@2|Bacteria,COG1520@2|Bacteria 2|Bacteria S amino acid activation for nonribosomal peptide biosynthetic process - - 3.4.17.18 ko:K05996 - - - - ko00000,ko01000,ko01002 - - - 5_nucleotid_C,Cytochrome_C554,SBP_bac_8,SLH SRD1_k127_71514_1 1245471.PCA10_04950 2.183e-59 220.0 COG0702@1|root,COG0702@2|Bacteria,1PHX2@1224|Proteobacteria,1TBJ2@1236|Gammaproteobacteria,1YHTW@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria GM NmrA-like family - - - - - - - - - - - - NmrA SRD1_k127_7156334_3 945713.IALB_1799 4.96e-43 174.0 COG1196@1|root,COG1196@2|Bacteria 2|Bacteria D nuclear chromosome segregation - - - - - - - - - - - - Ead_Ea22 SRD1_k127_7156334_2 290318.Cvib_0880 3.713e-81 281.0 COG0078@1|root,COG0078@2|Bacteria,1FDDG@1090|Chlorobi 1090|Chlorobi E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline argF - 2.1.3.3 ko:K00611 ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230 M00029,M00844 R01398 RC00096 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N SRD1_k127_7156334_5 556267.HWAG_00992 7.933e-08 60.0 COG1734@1|root,COG1734@2|Bacteria,1RD08@1224|Proteobacteria,42RVK@68525|delta/epsilon subdivisions,2YT6X@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T DnaK suppressor protein dksA - - ko:K06204 ko02026,map02026 - - - ko00000,ko00001,ko03000,ko03009,ko03021 - - - zf-dskA_traR SRD1_k127_7156334_0 1123242.JH636434_gene3888 1.528e-148 485.0 COG1249@1|root,COG1249@2|Bacteria,2IX5H@203682|Planctomycetes 203682|Planctomycetes C COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase (E3) - - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyr_redox_2,Pyr_redox_dim SRD1_k127_7156334_1 1489678.RDMS_05355 7.841e-99 340.0 COG0508@1|root,COG0508@2|Bacteria,1WI1G@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus C Component of pyruvate dehydrogenase complex - - 2.3.1.12 ko:K00627 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00209,R02569 RC00004,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding SRD1_k127_7156334_4 945713.IALB_2978 2.706e-37 143.0 COG2609@1|root,COG2609@2|Bacteria 2|Bacteria C pyruvate dehydrogenase (acetyl-transferring) activity aceE - 1.2.4.1 ko:K00163 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transketolase_N SRD1_k127_7161527_0 945713.IALB_0288 8.056e-127 437.0 COG2844@1|root,COG2844@2|Bacteria 2|Bacteria O Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen glnD - 1.1.1.3,1.4.1.2,2.7.7.19,2.7.7.42,2.7.7.59,2.7.7.72,2.7.7.89 ko:K00003,ko:K00970,ko:K00974,ko:K00982,ko:K00990,ko:K06950,ko:K15371 ko00220,ko00250,ko00260,ko00270,ko00300,ko00430,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,ko02020,ko03013,ko03018,map00220,map00250,map00260,map00270,map00300,map00430,map00910,map01100,map01110,map01120,map01130,map01230,map02020,map03013,map03018 M00017,M00018 R00243,R01773,R01775,R09382,R09383,R09384,R09386 RC00006,RC00078,RC00087,RC02799 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - ACT,GlnD_UR_UTase,HD,NTP_transf_2,PolyA_pol,PolyA_pol_RNAbd SRD1_k127_7172002_3 583355.Caka_0158 0.0001422 45.0 COG1538@1|root,COG1538@2|Bacteria,46T0P@74201|Verrucomicrobia,3K73I@414999|Opitutae 414999|Opitutae MU PFAM outer membrane efflux protein - - - - - - - - - - - - OEP SRD1_k127_7172002_0 1191523.MROS_2281 2.647e-115 385.0 COG0845@1|root,COG0845@2|Bacteria 2|Bacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family macA - - ko:K02005 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23,OEP SRD1_k127_7172002_1 945713.IALB_1699 5.48e-106 348.0 COG1136@1|root,COG1136@2|Bacteria 2|Bacteria V lipoprotein transporter activity macB - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran SRD1_k127_7172002_2 517418.Ctha_0585 4.213e-80 278.0 COG0577@1|root,COG0577@2|Bacteria,1FDSK@1090|Chlorobi 1090|Chlorobi V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD SRD1_k127_717761_1 1201290.M902_0944 6.492e-07 53.0 COG0803@1|root,COG0803@2|Bacteria,1MVW9@1224|Proteobacteria,42MBX@68525|delta/epsilon subdivisions,2MTWE@213481|Bdellovibrionales,2WQ7S@28221|Deltaproteobacteria 213481|Bdellovibrionales P Belongs to the bacterial solute-binding protein 9 family - - - ko:K02077 - M00244 - - ko00000,ko00002,ko02000 3.A.1.15 - - ZnuA SRD1_k127_717761_0 404589.Anae109_1534 5.948e-27 124.0 COG3170@1|root,COG3170@2|Bacteria,1QX7F@1224|Proteobacteria,42NQR@68525|delta/epsilon subdivisions,2WRZ7@28221|Deltaproteobacteria,2YYH9@29|Myxococcales 28221|Deltaproteobacteria NU Tfp pilus assembly protein FimV - - - - - - - - - - - - - SRD1_k127_7183754_1 945713.IALB_1682 2.184e-31 127.0 COG4980@1|root,COG4980@2|Bacteria 2|Bacteria D gas vesicle protein XK27_07760 - - - - - - - - - - - YtxH SRD1_k127_7183754_0 945713.IALB_1680 1.368e-269 847.0 COG0480@1|root,COG0480@2|Bacteria 2|Bacteria J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA2 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0030312,GO:0044237,GO:0044464,GO:0071944 - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 SRD1_k127_7193487_2 1349822.NSB1T_13275 3.86e-06 51.0 COG3250@1|root,COG3250@2|Bacteria,4P0A0@976|Bacteroidetes,2FPPP@200643|Bacteroidia 976|Bacteroidetes G Belongs to the glycosyl hydrolase 2 family - - - - - - - - - - - - Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N,PA14 SRD1_k127_7193487_0 160799.PBOR_30720 1.984e-137 467.0 COG0383@1|root,COG0383@2|Bacteria,1TQEH@1239|Firmicutes,4HF4F@91061|Bacilli,26VTM@186822|Paenibacillaceae 91061|Bacilli G Alpha mannosidase, middle domain - - 3.2.1.24 ko:K01191 ko00511,map00511 - - - ko00000,ko00001,ko01000,ko04131 - GH38 - Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C SRD1_k127_7193487_1 1168289.AJKI01000053_gene789 2.477e-40 164.0 COG0591@1|root,COG0591@2|Bacteria,4PKHI@976|Bacteroidetes,2FQHR@200643|Bacteroidia,3XJ59@558415|Marinilabiliaceae 976|Bacteroidetes E Sodium:solute symporter family - - - - - - - - - - - - SSF SRD1_k127_7195151_0 1519464.HY22_04465 2.212e-50 184.0 COG1595@1|root,COG1595@2|Bacteria,1FE7H@1090|Chlorobi 1090|Chlorobi K PFAM sigma-70 region 2 domain protein - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 SRD1_k127_7195151_1 2754.EH55_10330 8.268e-46 170.0 COG0537@1|root,COG0537@2|Bacteria,3TB29@508458|Synergistetes 508458|Synergistetes FG PFAM histidine triad (HIT) protein - - 2.7.7.53 ko:K19710 ko00230,map00230 - R00126,R01618 RC00002,RC02753,RC02795 ko00000,ko00001,ko01000 - - - HIT SRD1_k127_7206609_1 1519464.HY22_13055 1.965e-22 113.0 COG0265@1|root,COG0366@1|root,COG0265@2|Bacteria,COG0366@2|Bacteria 2|Bacteria G hydrolase activity, hydrolyzing O-glycosyl compounds - - 3.4.21.50 ko:K01337 - - - - ko00000,ko01000,ko01002 - - - Alpha-amylase SRD1_k127_7206609_2 1408303.JNJJ01000091_gene2454 1.635e-16 94.0 COG3266@1|root,COG4676@1|root,COG3266@2|Bacteria,COG4676@2|Bacteria,1VDA3@1239|Firmicutes,4ITGR@91061|Bacilli,1ZDHT@1386|Bacillus 91061|Bacilli S domain, Protein - - - - - - - - - - - - Flg_new,TPR_19 SRD1_k127_7206609_0 935845.JADQ01000018_gene3826 1.49e-72 248.0 COG3537@1|root,COG3537@2|Bacteria,1TQAG@1239|Firmicutes,4HBMP@91061|Bacilli,26VY4@186822|Paenibacillaceae 91061|Bacilli G Glycosyl hydrolase family 92 - - - - - - - - - - - - CBM_6,F5_F8_type_C,Glyco_hydro_92 SRD1_k127_7209676_3 714943.Mucpa_2476 1.298e-18 88.0 COG3533@1|root,COG3533@2|Bacteria,4NF8W@976|Bacteroidetes,1IP7E@117747|Sphingobacteriia 976|Bacteroidetes S COGs COG3533 conserved - - - ko:K09955 - - - - ko00000 - - - DUF4986,Glyco_hydro_127 SRD1_k127_7209676_2 1519464.HY22_00560 9.955e-60 233.0 COG3292@1|root,COG4447@1|root,COG3292@2|Bacteria,COG4447@2|Bacteria 2|Bacteria S cellulose binding - - - - - - - - - - - - BNR,Reprolysin_5 SRD1_k127_7209676_0 1519464.HY22_03865 2.548e-152 494.0 COG0738@1|root,COG0738@2|Bacteria 2|Bacteria G Major facilitator superfamily gluP - - ko:K02429 - - - - ko00000,ko02000 2.A.1.7 - - MFS_1 SRD1_k127_7209676_1 880073.Calab_0637 9.254e-128 430.0 COG0760@1|root,COG0760@2|Bacteria,2NPQV@2323|unclassified Bacteria 2|Bacteria O PPIC-type PPIASE domain - - 5.2.1.8 ko:K03769 - - - - ko00000,ko01000,ko03110 - - - Cu_amine_oxidN1,Rotamase,Rotamase_2,Rotamase_3,SurA_N_3 SRD1_k127_7214103_2 240015.ACP_2429 7.15e-06 56.0 COG3250@1|root,COG3250@2|Bacteria,3Y2PR@57723|Acidobacteria,2JI9N@204432|Acidobacteriia 204432|Acidobacteriia G Belongs to the glycosyl hydrolase 2 family - - - - - - - - - - - - Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N,Laminin_G_3 SRD1_k127_7214103_0 452637.Oter_1126 1.11e-238 758.0 COG4733@1|root,COG5368@1|root,COG4733@2|Bacteria,COG5368@2|Bacteria 2|Bacteria S Putative glucoamylase - - 3.2.1.14 ko:K01183 ko00520,ko01100,map00520,map01100 - R01206,R02334 RC00467 ko00000,ko00001,ko01000 - GH18 - Glycoamylase,fn3 SRD1_k127_7214103_1 945713.IALB_1183 1.661e-57 207.0 COG3387@1|root,COG3387@2|Bacteria 2|Bacteria G glucan 1,4-alpha-glucosidase activity - - 3.2.1.3 ko:K01178 ko00500,ko01100,map00500,map01100 - R01790,R01791,R06199 - ko00000,ko00001,ko01000 - GH15 - Glyco_hydro_15 SRD1_k127_7217195_1 1041138.KB890255_gene2989 1.298e-118 393.0 COG2195@1|root,COG2195@2|Bacteria,1MV7D@1224|Proteobacteria,2TRNW@28211|Alphaproteobacteria,4B80H@82115|Rhizobiaceae 28211|Alphaproteobacteria E Cleaves the N-terminal amino acid of tripeptides pepT - 3.4.11.4 ko:K01258 - - - - ko00000,ko01000,ko01002 - - - M20_dimer,Peptidase_M20 SRD1_k127_7217195_3 240016.ABIZ01000001_gene5808 1.583e-16 86.0 COG2010@1|root,COG2010@2|Bacteria,46TBB@74201|Verrucomicrobia 74201|Verrucomicrobia C Cytochrome c - - - - - - - - - - - - Cytochrom_C SRD1_k127_7217195_2 945713.IALB_3168 1.522e-57 203.0 COG2872@1|root,COG2872@2|Bacteria 2|Bacteria S Ser-tRNA(Ala) hydrolase activity amyA - - - - - - - - - - - Alpha-amylase,tRNA_SAD SRD1_k127_7217195_0 945713.IALB_0982 3.959e-124 420.0 COG1305@1|root,COG1305@2|Bacteria 2|Bacteria E Transglutaminase-like superfamily - - - - - - - - - - - - Transglut_core SRD1_k127_7219132_0 880073.Calab_0243 1.996e-104 346.0 COG1192@1|root,COG1192@2|Bacteria,2NP2C@2323|unclassified Bacteria 2|Bacteria D Cobyrinic acid ac-diamide synthase soj GO:0008150,GO:0022603,GO:0042173,GO:0042174,GO:0043937,GO:0043939,GO:0045595,GO:0045596,GO:0048519,GO:0048523,GO:0050789,GO:0050793,GO:0050794,GO:0051093,GO:0065007 - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 SRD1_k127_7219132_2 517418.Ctha_2650 8.931e-79 274.0 COG1475@1|root,COG1475@2|Bacteria,1FDJC@1090|Chlorobi 1090|Chlorobi K Belongs to the ParB family - - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc SRD1_k127_7219132_4 515635.Dtur_1336 1.138e-40 154.0 COG0251@1|root,COG0251@2|Bacteria 2|Bacteria J oxidation-reduction process - - 3.5.99.10 ko:K09022 - - R11098,R11099 RC03275,RC03354 ko00000,ko01000 - - - Ribonuc_L-PSP SRD1_k127_7219132_1 1191523.MROS_2404 2.656e-79 275.0 COG0700@1|root,COG2715@1|root,COG0700@2|Bacteria,COG2715@2|Bacteria 2|Bacteria S Nucleoside recognition spmB - - ko:K06373,ko:K06374 - - - - ko00000 - - - Gate SRD1_k127_7219132_3 1191523.MROS_2404 5.597e-66 229.0 COG0700@1|root,COG2715@1|root,COG0700@2|Bacteria,COG2715@2|Bacteria 2|Bacteria S Nucleoside recognition spmB - - ko:K06373,ko:K06374 - - - - ko00000 - - - Gate SRD1_k127_7226686_1 1403819.BATR01000051_gene1500 1.115e-44 169.0 COG3616@1|root,COG3616@2|Bacteria,46TAP@74201|Verrucomicrobia 74201|Verrucomicrobia E Putative serine dehydratase domain - - - - - - - - - - - - Ala_racemase_N,D-ser_dehydrat SRD1_k127_7226686_3 1191523.MROS_2080 1.992e-25 124.0 COG0737@1|root,COG3693@1|root,COG0737@2|Bacteria,COG3693@2|Bacteria 2|Bacteria G endo-1,4-beta-xylanase activity xynX5 - 3.2.1.202,3.2.1.8 ko:K01181,ko:K21606 - - - - ko00000,ko01000 - CBM5,GH18 - 5_nucleotid_C,CBM_4_9,LRR_5,Metallophos,Phytase-like,SLH SRD1_k127_7226686_2 945713.IALB_0188 1.031e-31 143.0 COG1649@1|root,COG4733@1|root,COG1649@2|Bacteria,COG4733@2|Bacteria 2|Bacteria S cellulase activity J - 3.2.1.11,3.2.1.18,3.2.1.35 ko:K01186,ko:K01197,ko:K05988,ko:K11931,ko:K21449 ko00500,ko00511,ko00531,ko00600,ko01100,ko02026,ko04142,map00500,map00511,map00531,map00600,map01100,map02026,map04142 M00076,M00077 R04018,R07824,R07825,R10905,R11309 RC00028,RC00077 ko00000,ko00001,ko00002,ko00536,ko00537,ko01000,ko02000,ko02042 1.B.40.2 GH33,GH66 - DUF1983,DUF3672,Phage-tail_3 SRD1_k127_7226686_0 247490.KSU1_C0449 3.254e-84 304.0 COG2931@1|root,COG2931@2|Bacteria 2|Bacteria Q calcium- and calmodulin-responsive adenylate cyclase activity - - - - - - - - - - - - Cadherin_3,DUF4347,Peptidase_S8 SRD1_k127_7264771_3 204669.Acid345_3551 2.607e-25 108.0 COG0454@1|root,COG0456@2|Bacteria,3Y5G1@57723|Acidobacteria,2JJWU@204432|Acidobacteriia 204432|Acidobacteriia K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1 SRD1_k127_7264771_1 945713.IALB_0515 1.748e-65 230.0 COG1225@1|root,COG1225@2|Bacteria 2|Bacteria O peroxiredoxin activity - - - - - - - - - - - - AhpC-TSA SRD1_k127_7264771_0 1379698.RBG1_1C00001G0558 1.539e-98 334.0 COG3391@1|root,COG3391@2|Bacteria 2|Bacteria CO amine dehydrogenase activity - - - - - - - - - - - - Big_3_5,Calx-beta,FG-GAP,VCBS SRD1_k127_7264771_2 1185876.BN8_02295 4.763e-63 219.0 COG0702@1|root,COG0702@2|Bacteria,4NGMR@976|Bacteroidetes,47NYS@768503|Cytophagia 976|Bacteroidetes GM epimerase - - - - - - - - - - - - Epimerase SRD1_k127_7280564_2 945713.IALB_2192 8.869e-134 432.0 COG0540@1|root,COG0540@2|Bacteria 2|Bacteria F Belongs to the ATCase OTCase family pyrB GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.3.2 ko:K00608,ko:K00609 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002,ko01000 - - iYO844.BSU15490 OTCace,OTCace_N SRD1_k127_7280564_1 945713.IALB_2191 2.953e-144 469.0 COG0044@1|root,COG0044@2|Bacteria 2|Bacteria F hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides pyrC GO:0003674,GO:0003824,GO:0004038,GO:0004151,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046390,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1 SRD1_k127_7280564_5 945713.IALB_2190 4.58e-85 289.0 COG4733@1|root,COG4733@2|Bacteria 2|Bacteria S cellulase activity - - - ko:K06882 - - - - ko00000 - - - fn3 SRD1_k127_7280564_3 1089550.ATTH01000001_gene694 1.094e-107 391.0 COG5000@1|root,COG5000@2|Bacteria,4NE49@976|Bacteroidetes,1FJ03@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain zraS_1 - - - - - - - - - - - HATPase_c,HisKA SRD1_k127_7280564_6 504472.Slin_3530 1.658e-45 180.0 COG1496@1|root,COG1496@2|Bacteria,4NM9H@976|Bacteroidetes,47JW0@768503|Cytophagia 976|Bacteroidetes S Belongs to the multicopper oxidase YfiH RL5 family - GO:0003674,GO:0003824,GO:0005488,GO:0005507,GO:0005515,GO:0008150,GO:0008152,GO:0016491,GO:0016679,GO:0016682,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0046983,GO:0055114 - ko:K05810 - - - - ko00000,ko01000 - - - Cu-oxidase_4 SRD1_k127_7280564_0 1519464.HY22_02080 6.35e-255 799.0 COG0449@1|root,COG0449@2|Bacteria,1FDCR@1090|Chlorobi 1090|Chlorobi M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source glmS - 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - - GATase_6,SIS SRD1_k127_7280564_4 1191523.MROS_0289 1.003e-106 353.0 COG0623@1|root,COG0623@2|Bacteria 2|Bacteria I enoyl-[acyl-carrier-protein] reductase (NADH) activity - - 1.3.1.104 ko:K10780 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00083 R01404,R04430,R04725,R04956,R04959,R04962,R04967,R04970 RC00052,RC00076,RC00120 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 SRD1_k127_7323054_3 709986.Deima_2139 2.701e-77 269.0 COG0395@1|root,COG0395@2|Bacteria 2|Bacteria P glycerophosphodiester transmembrane transport irk - - ko:K02026,ko:K08715 - M00207 - - ko00000,ko00002,ko02000 1.A.2.2,3.A.1.1 - - IRK SRD1_k127_7323054_2 880073.Calab_3770 6.162e-124 420.0 COG1305@1|root,COG1305@2|Bacteria 2|Bacteria E Transglutaminase-like superfamily - - - - - - - - - - - - DUF3857,DUF3858,Transglut_core SRD1_k127_7323054_8 760192.Halhy_3720 4.525e-40 168.0 COG0457@1|root,COG0457@2|Bacteria,4NTC7@976|Bacteroidetes 976|Bacteroidetes S Tetratricopeptide repeat - - - - - - - - - - - - - SRD1_k127_7323054_9 483219.LILAB_17690 5.03e-33 141.0 COG2887@1|root,COG2887@2|Bacteria,1QXTW@1224|Proteobacteria,43C6C@68525|delta/epsilon subdivisions,2X7GI@28221|Deltaproteobacteria,2YZ5R@29|Myxococcales 28221|Deltaproteobacteria L PD-(D/E)XK nuclease superfamily - - - - - - - - - - - - PDDEXK_1 SRD1_k127_7323054_11 1304284.L21TH_1366 3.096e-20 107.0 COG0419@1|root,COG0419@2|Bacteria,1UQNY@1239|Firmicutes,24UHC@186801|Clostridia 186801|Clostridia L AAA domain - - - ko:K03546 - - - - ko00000,ko03400 - - - AAA_27 SRD1_k127_7323054_12 1403819.BATR01000086_gene2524 9.566e-08 66.0 COG0419@1|root,COG0419@2|Bacteria,46ZK9@74201|Verrucomicrobia,2IVGA@203494|Verrucomicrobiae 203494|Verrucomicrobiae L AAA domain - - - - - - - - - - - - AAA_23 SRD1_k127_7323054_4 1304284.L21TH_2026 4.599e-71 254.0 COG0420@1|root,COG0420@2|Bacteria,1V3MP@1239|Firmicutes,24J4M@186801|Clostridia 186801|Clostridia L Calcineurin-like phosphoesterase superfamily domain - - - - - - - - - - - - Metallophos SRD1_k127_7323054_0 234267.Acid_0394 1.005e-221 702.0 COG2204@1|root,COG2204@2|Bacteria 2|Bacteria T phosphorelay signal transduction system - - - ko:K02481,ko:K07713,ko:K07714 ko02020,map02020 M00499,M00500 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat SRD1_k127_7323054_7 234267.Acid_0393 1.05e-44 168.0 COG1913@1|root,COG1913@2|Bacteria 2|Bacteria S metallopeptidase activity - - - ko:K06974 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M54 SRD1_k127_7323054_1 234267.Acid_0392 1.577e-181 585.0 COG4191@1|root,COG4191@2|Bacteria,3Y42C@57723|Acidobacteria 57723|Acidobacteria T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - 2.7.13.3 ko:K02482 - - - - ko00000,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA SRD1_k127_7323054_10 1219045.BV98_002485 5.482e-21 97.0 COG3668@1|root,32ZH9@2|Bacteria,1N7YH@1224|Proteobacteria,2UC0X@28211|Alphaproteobacteria,2K645@204457|Sphingomonadales 204457|Sphingomonadales S Plasmid stabilization - - - - - - - - - - - - - SRD1_k127_7323054_6 649638.Trad_2541 1.606e-47 174.0 COG1764@1|root,COG1764@2|Bacteria,1WJVD@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus O redox protein regulator of disulfide bond formation osmC - - ko:K04063 - - - - ko00000 - - - OsmC SRD1_k127_7323054_5 1121918.ARWE01000001_gene1147 7.704e-57 216.0 COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,42MMA@68525|delta/epsilon subdivisions,2WIZB@28221|Deltaproteobacteria,43S72@69541|Desulfuromonadales 28221|Deltaproteobacteria M Surface antigen bamA - - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA SRD1_k127_7335135_0 945713.IALB_1137 3.122e-190 609.0 COG1574@1|root,COG1574@2|Bacteria 2|Bacteria G metal-dependent hydrolase with the TIM-barrel fold - - - - - - - - - - - - Amidohydro_3 SRD1_k127_7335135_2 215803.DB30_2898 1.782e-67 255.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,43BYI@68525|delta/epsilon subdivisions,2X79E@28221|Deltaproteobacteria 28221|Deltaproteobacteria T GHKL domain - - - - - - - - - - - - HATPase_c,HisKA,PAS_4 SRD1_k127_7335135_1 1379698.RBG1_1C00001G0607 2.25e-102 349.0 COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2NQNE@2323|unclassified Bacteria 2|Bacteria T Serine threonine protein kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PASTA,Pkinase,TPR_2,TPR_8 SRD1_k127_7344429_1 1191523.MROS_2599 7.456e-84 287.0 COG0265@1|root,COG0265@2|Bacteria 2|Bacteria O serine-type endopeptidase activity htrA - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_1,PDZ_2,Trypsin_2 SRD1_k127_7344429_2 1519464.HY22_04640 1.295e-66 235.0 COG1403@1|root,COG1403@2|Bacteria,1FDXZ@1090|Chlorobi 1090|Chlorobi L PFAM HNH endonuclease - - - - - - - - - - - - HNH,HNH_5 SRD1_k127_7344429_0 1191523.MROS_2554 1.017e-133 430.0 COG0180@1|root,COG0180@2|Bacteria 2|Bacteria J Tryptophanyl-tRNA synthetase trpS GO:0003674,GO:0003824,GO:0004812,GO:0004830,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006436,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.2 ko:K01867 ko00970,map00970 M00359,M00360 R03664 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1b SRD1_k127_7376239_1 880073.Calab_1320 7.028e-06 58.0 COG0739@1|root,COG0739@2|Bacteria,2NR6F@2323|unclassified Bacteria 2|Bacteria M Peptidase family M23 - - - - - - - - - - - - Peptidase_M23 SRD1_k127_7376239_0 635013.TherJR_2557 1.244e-285 902.0 COG0525@1|root,COG0525@2|Bacteria,1TPN4@1239|Firmicutes,248VC@186801|Clostridia,25ZYN@186807|Peptococcaceae 186801|Clostridia J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS - 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 SRD1_k127_7383095_0 1379698.RBG1_1C00001G0961 1.443e-185 594.0 COG0550@1|root,COG0550@2|Bacteria,2NNS8@2323|unclassified Bacteria 2|Bacteria L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone topA - 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topoisom_bac,Toprim,zf-C4_Topoisom SRD1_k127_7383095_1 626939.HMPREF9443_00223 7.94e-68 243.0 COG4974@1|root,COG4974@2|Bacteria,1TPQB@1239|Firmicutes,4H2GY@909932|Negativicutes 909932|Negativicutes D tyrosine recombinase XerC xerC - - ko:K03733 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase SRD1_k127_7383095_2 945713.IALB_1567 1.169e-14 80.0 COG1544@1|root,COG1544@2|Bacteria 2|Bacteria J regulation of translation raiA - - ko:K03733,ko:K05808,ko:K05809 - - - - ko00000,ko03009,ko03036 - - - Ribosom_S30AE_C,Ribosomal_S30AE SRD1_k127_739007_9 118166.JH976537_gene2203 2.889e-07 54.0 COG3693@1|root,COG3693@2|Bacteria,1GI7D@1117|Cyanobacteria,1HE3X@1150|Oscillatoriales 1117|Cyanobacteria G Glycosyl hydrolase family 10 - - - - - - - - - - - - Glyco_hydro_10 SRD1_k127_739007_7 1229172.JQFA01000002_gene4789 3.353e-70 261.0 COG3693@1|root,COG3693@2|Bacteria,1GI7D@1117|Cyanobacteria,1HE3X@1150|Oscillatoriales 1117|Cyanobacteria G Glycosyl hydrolase family 10 - - - - - - - - - - - - Glyco_hydro_10 SRD1_k127_739007_5 497965.Cyan7822_4979 2.218e-85 303.0 COG3693@1|root,COG3693@2|Bacteria,1GK4C@1117|Cyanobacteria,3KJ14@43988|Cyanothece 1117|Cyanobacteria G PFAM glycoside hydrolase family 10 - - 3.2.1.8 ko:K01181 - - - - ko00000,ko01000 - - - Glyco_hydro_10 SRD1_k127_739007_3 697281.Mahau_2859 6.41e-88 303.0 COG0407@1|root,COG0407@2|Bacteria 697281.Mahau_2859|- H Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III - - - - - - - - - - - - - SRD1_k127_739007_2 1189612.A33Q_4576 4.434e-99 352.0 COG0366@1|root,COG0366@2|Bacteria,4NEXF@976|Bacteroidetes,47MR6@768503|Cytophagia 976|Bacteroidetes G PFAM Alpha amylase, catalytic - GO:0000272,GO:0000287,GO:0001871,GO:0003674,GO:0003824,GO:0004553,GO:0004556,GO:0005488,GO:0005509,GO:0005575,GO:0005975,GO:0005976,GO:0005982,GO:0005983,GO:0006073,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009251,GO:0009987,GO:0016020,GO:0016052,GO:0016160,GO:0016787,GO:0016798,GO:0019867,GO:0030246,GO:0030247,GO:0043167,GO:0043169,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0046872,GO:0071704,GO:1901575,GO:2001070 3.2.1.1,3.2.1.133,3.2.1.135,3.2.1.54 ko:K01176,ko:K01208 ko00500,ko01100,ko04973,map00500,map01100,map04973 - R02108,R02112,R03122,R11262 - ko00000,ko00001,ko01000 - GH13 - Alpha-amylase,BACON,Malt_amylase_C SRD1_k127_739007_8 1191523.MROS_0081 1.368e-22 114.0 COG0737@1|root,COG3291@1|root,COG0737@2|Bacteria,COG3291@2|Bacteria 2|Bacteria S metallopeptidase activity xynX5 - 3.2.1.4,3.2.1.8 ko:K01179,ko:K01181 ko00500,ko01100,map00500,map01100 - R06200,R11307,R11308 - ko00000,ko00001,ko01000 - GH5,GH9 - Beta_helix,IgGFc_binding,Metallophos,PKD,SLH SRD1_k127_739007_10 1273538.G159_02435 3.421e-05 49.0 COG0451@1|root,COG0451@2|Bacteria,1TR3K@1239|Firmicutes,4HD3P@91061|Bacilli,26DWX@186818|Planococcaceae 91061|Bacilli GM NAD dependent epimerase/dehydratase family - - 1.3.1.45 ko:K05281 ko00943,ko01110,map00943,map01110 - R06562,R06563,R07747,R07751 RC00805 ko00000,ko00001,ko01000 - - - Epimerase SRD1_k127_739007_0 1502724.FF80_01231 1.48e-160 541.0 COG3250@1|root,COG3250@2|Bacteria,1MVBN@1224|Proteobacteria,2U0KF@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Belongs to the glycosyl hydrolase 2 family - - 3.2.1.31 ko:K01195 ko00040,ko00531,ko00860,ko00944,ko00983,ko01100,ko01110,ko04142,map00040,map00531,map00860,map00944,map00983,map01100,map01110,map04142 M00014,M00076,M00077,M00078,M00129 R01478,R04979,R07818,R08127,R08260,R10830 RC00055,RC00171,RC00529,RC00530,RC00714,RC01251 ko00000,ko00001,ko00002,ko01000 - - - Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N SRD1_k127_739007_6 1303518.CCALI_02848 1.521e-78 277.0 COG5285@1|root,COG5285@2|Bacteria 2|Bacteria Q dioxygenase activity - - - - - - - - - - - - PhyH SRD1_k127_739007_4 1173023.KE650771_gene2605 1.429e-87 301.0 COG3386@1|root,COG3386@2|Bacteria,1G05C@1117|Cyanobacteria 1117|Cyanobacteria G PFAM SMP-30 Gluconolaconase LRE-like region - - - - - - - - - - - - SGL SRD1_k127_739007_1 1304880.JAGB01000003_gene1239 1.158e-112 370.0 COG1957@1|root,COG1957@2|Bacteria,1TSSS@1239|Firmicutes,24A4D@186801|Clostridia 186801|Clostridia F Psort location Cytoplasmic, score - - 3.2.2.1 ko:K01239 ko00230,ko00760,ko01100,map00230,map00760,map01100 - R01245,R01273,R01677,R01770,R02143 RC00033,RC00063,RC00122,RC00318,RC00485 ko00000,ko00001,ko01000 - - - IU_nuc_hydro SRD1_k127_7414342_0 945713.IALB_3204 1.454e-102 343.0 COG0706@1|root,COG0706@2|Bacteria 2|Bacteria U membrane insertase activity yidC GO:0002790,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006457,GO:0006810,GO:0008104,GO:0008150,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0022607,GO:0031224,GO:0031226,GO:0032940,GO:0032977,GO:0033036,GO:0034613,GO:0042886,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051205,GO:0051234,GO:0051259,GO:0051260,GO:0051641,GO:0061024,GO:0065003,GO:0070727,GO:0071702,GO:0071705,GO:0071840,GO:0071944,GO:0072657,GO:0090150 - ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 - - 60KD_IMP,YidC_periplas SRD1_k127_7414342_1 1191523.MROS_1001 5.078e-71 248.0 COG0486@1|root,COG0486@2|Bacteria 2|Bacteria S GTPase activity mnmE GO:0003674,GO:0005488,GO:0005515,GO:0042802 - ko:K03650 - - R08701 RC00053,RC00209,RC00870 ko00000,ko01000,ko03016 - - - MMR_HSR1,MnmE_helical,TrmE_N SRD1_k127_7427566_3 205922.Pfl01_3435 2.299e-11 76.0 COG3540@1|root,COG3540@2|Bacteria,1R6R7@1224|Proteobacteria,1RYX6@1236|Gammaproteobacteria,1YRXW@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria P PhoD-like phosphatase - - - - - - - - - - - - PhoD SRD1_k127_7427566_1 1519464.HY22_13055 8.594e-26 123.0 COG0265@1|root,COG0366@1|root,COG0265@2|Bacteria,COG0366@2|Bacteria 2|Bacteria G hydrolase activity, hydrolyzing O-glycosyl compounds - - 3.4.21.50 ko:K01337 - - - - ko00000,ko01000,ko01002 - - - Alpha-amylase SRD1_k127_7427566_0 1183438.GKIL_2649 1.41e-127 423.0 COG3503@1|root,COG3503@2|Bacteria 2|Bacteria J Membrane - - - - - - - - - - - - DUF1624,DUF418 SRD1_k127_7427566_2 289376.THEYE_A1537 1.767e-18 86.0 COG2876@1|root,COG2876@2|Bacteria,3J0A5@40117|Nitrospirae 40117|Nitrospirae E NeuB family - - 2.5.1.54 ko:K03856 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 - - - DAHP_synth_1 SRD1_k127_7434621_3 1123257.AUFV01000001_gene1707 7.964e-23 104.0 COG3795@1|root,COG3795@2|Bacteria,1RCZT@1224|Proteobacteria,1S8E3@1236|Gammaproteobacteria,1XACI@135614|Xanthomonadales 135614|Xanthomonadales S YCII-related domain - - - - - - - - - - - - YCII SRD1_k127_7434621_1 1459636.NTE_01132 7.013e-75 256.0 COG3865@1|root,arCOG09469@2157|Archaea 2157|Archaea S PFAM 3-demethylubiquinone-9 - - - ko:K04750 - - - - ko00000 - - - 3-dmu-9_3-mt SRD1_k127_7434621_4 469382.Hbor_22220 1.549e-09 64.0 arCOG08914@1|root,arCOG08914@2157|Archaea,2XZSA@28890|Euryarchaeota,23XNV@183963|Halobacteria 183963|Halobacteria - - - - - - - - - - - - - - - SRD1_k127_7434621_0 880072.Desac_1035 2.383e-270 864.0 COG0067@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0070@2|Bacteria,1NZ4D@1224|Proteobacteria,43B3T@68525|delta/epsilon subdivisions,2X6HR@28221|Deltaproteobacteria 28221|Deltaproteobacteria E GXGXG motif - - - - - - - - - - - - GATase_6,GXGXG SRD1_k127_7434621_2 880072.Desac_1036 2.021e-61 214.0 COG0069@1|root,COG1145@1|root,COG0069@2|Bacteria,COG1145@2|Bacteria,1MU7B@1224|Proteobacteria,42MF7@68525|delta/epsilon subdivisions,2WJBR@28221|Deltaproteobacteria 28221|Deltaproteobacteria E Glutamate synthase - - - - - - - - - - - - Fer4,Glu_synthase SRD1_k127_7443972_0 234267.Acid_3443 2.634e-169 547.0 COG3975@1|root,COG3975@2|Bacteria,3Y411@57723|Acidobacteria 57723|Acidobacteria S PFAM peptidase M61 - - - - - - - - - - - - Peptidase_M61 SRD1_k127_7451349_1 1122931.AUAE01000013_gene2070 7.423e-07 60.0 COG1538@1|root,COG1538@2|Bacteria,4P2W9@976|Bacteroidetes,2FXFX@200643|Bacteroidia,23040@171551|Porphyromonadaceae 976|Bacteroidetes MU Outer membrane efflux protein - - - - - - - - - - - - OEP SRD1_k127_7451349_0 1288963.ADIS_1550 6.7e-103 351.0 COG0577@1|root,COG0577@2|Bacteria,4NEBD@976|Bacteroidetes,47XCU@768503|Cytophagia 976|Bacteroidetes V ABC-type antimicrobial peptide transport system, permease component - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD SRD1_k127_7451349_2 1340493.JNIF01000003_gene2326 4.319e-05 48.0 COG1566@1|root,COG1566@2|Bacteria 2|Bacteria V PFAM secretion protein HlyD family protein - - - ko:K02005,ko:K02022 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD_3 SRD1_k127_74685_2 316067.Geob_1640 6.474e-67 235.0 COG3861@1|root,COG3861@2|Bacteria,1QYWN@1224|Proteobacteria,43E8W@68525|delta/epsilon subdivisions 1224|Proteobacteria S Protein of unknown function (DUF3341) - - - - - - - - - - - - DUF3341 SRD1_k127_74685_1 194439.CT0103 7.859e-80 269.0 COG0229@1|root,COG0229@2|Bacteria,1FDWG@1090|Chlorobi 1090|Chlorobi C PFAM Methionine sulfoxide reductase B msrB - 1.8.4.12 ko:K07305 - - - - ko00000,ko01000 - - - SelR SRD1_k127_74685_0 880073.Calab_3330 1.911e-112 382.0 COG0492@1|root,COG1145@1|root,COG0492@2|Bacteria,COG1145@2|Bacteria,2NS2I@2323|unclassified Bacteria 2|Bacteria O Pyridine nucleotide-disulphide oxidoreductase trxB_2 - 1.18.1.2,1.19.1.1,1.8.1.9 ko:K00384,ko:K21567 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Fer4,Fer4_10,Pyr_redox_3 SRD1_k127_7475474_1 945713.IALB_0199 4.039e-28 130.0 COG0497@1|root,COG0497@2|Bacteria 2|Bacteria L DNA recombination recN - - ko:K03546,ko:K03631 - - - - ko00000,ko03400 - - - SMC_N SRD1_k127_7475474_2 945713.IALB_0200 2.194e-24 108.0 2FCWF@1|root,344ZB@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - SRD1_k127_7475474_4 220664.PFL_5826 5.475e-08 61.0 COG0745@1|root,COG0745@2|Bacteria,1RI9T@1224|Proteobacteria,1S4NE@1236|Gammaproteobacteria,1YQB1@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria KT Response regulator receiver domain pilH - - ko:K02658 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko02022,ko02035,ko02044 - - - Response_reg SRD1_k127_7475474_3 880072.Desac_0134 9.979e-15 83.0 COG1881@1|root,COG1881@2|Bacteria,1N0Y4@1224|Proteobacteria,42WMA@68525|delta/epsilon subdivisions,2WRGN@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Phosphatidylethanolamine-binding protein - - - ko:K06910 - - - - ko00000 - - - PBP SRD1_k127_7475474_0 1203611.KB894542_gene577 1.144e-34 135.0 COG1297@1|root,COG1297@2|Bacteria,4NEIY@976|Bacteroidetes,2FN5W@200643|Bacteroidia,22U4B@171550|Rikenellaceae 976|Bacteroidetes S OPT oligopeptide transporter protein - - - - - - - - - - - - OPT SRD1_k127_7488856_0 945713.IALB_1483 2.106e-179 571.0 COG0015@1|root,COG0015@2|Bacteria 2|Bacteria F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily purB GO:0003674,GO:0003824,GO:0004018,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016840,GO:0016842,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046033,GO:0046390,GO:0046483,GO:0055086,GO:0070626,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 - - iLJ478.TM1095,iSB619.SA_RS09895 ADSL_C,Lyase_1 SRD1_k127_7488856_2 945713.IALB_1484 5.775e-120 408.0 COG0265@1|root,COG0265@2|Bacteria 2|Bacteria O serine-type endopeptidase activity - - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 SRD1_k127_7488856_5 1191523.MROS_2697 4.531e-28 123.0 COG0344@1|root,COG0344@2|Bacteria 2|Bacteria I acyl-phosphate glycerol-3-phosphate acyltransferase activity plsY - 2.3.1.15 ko:K08591 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - G3P_acyltransf SRD1_k127_7488856_4 635013.TherJR_3000 2.999e-78 271.0 COG1691@1|root,COG1691@2|Bacteria,1TP0Z@1239|Firmicutes,24815@186801|Clostridia,260TX@186807|Peptococcaceae 186801|Clostridia S (AIR) carboxylase - - - ko:K06898 - - - - ko00000 - - - AIRC SRD1_k127_7488856_3 1128421.JAGA01000004_gene2595 5.687e-117 386.0 COG0039@1|root,COG0039@2|Bacteria,2NPA4@2323|unclassified Bacteria 2|Bacteria C lactate/malate dehydrogenase, alpha/beta C-terminal domain ldh - 1.1.1.27,1.1.1.37 ko:K00016,ko:K00024 ko00010,ko00020,ko00270,ko00620,ko00630,ko00640,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04922,map00010,map00020,map00270,map00620,map00630,map00640,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200,map04922 M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740 R00342,R00703,R01000,R03104,R07136 RC00031,RC00044 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Ldh_1_C,Ldh_1_N SRD1_k127_7488856_1 861299.J421_0897 6.534e-149 485.0 COG0031@1|root,COG0031@2|Bacteria,1ZTA6@142182|Gemmatimonadetes 142182|Gemmatimonadetes EK Domain in cystathionine beta-synthase and other proteins. - - 4.2.1.22 ko:K01697 ko00260,ko00270,ko01100,ko01130,ko01230,map00260,map00270,map01100,map01130,map01230 M00035,M00338 R00891,R01290,R04942 RC00056,RC00069,RC00256,RC00489,RC01246 ko00000,ko00001,ko00002,ko01000 - - - CBS,PALP SRD1_k127_751088_0 926569.ANT_01870 8.335e-132 430.0 COG2876@1|root,COG2876@2|Bacteria,2G643@200795|Chloroflexi 200795|Chloroflexi E PFAM DAHP synthetase I KDSA - - 2.5.1.54 ko:K03856 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 - - - DAHP_synth_1 SRD1_k127_751088_1 927658.AJUM01000043_gene703 1.268e-111 383.0 COG1408@1|root,COG1408@2|Bacteria,4NFCH@976|Bacteroidetes,2FQ9F@200643|Bacteroidia,3XJ9R@558415|Marinilabiliaceae 976|Bacteroidetes S Calcineurin-like phosphoesterase - - - ko:K07098 - - - - ko00000 - - - Metallophos SRD1_k127_751088_3 518766.Rmar_0338 1.571e-41 157.0 COG2967@1|root,COG2967@2|Bacteria,4NNRA@976|Bacteroidetes,1FJHH@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes P ApaG domain apaG - - ko:K06195 - - - - ko00000 - - - DUF525 SRD1_k127_751088_2 696281.Desru_0782 8.851e-46 175.0 COG0787@1|root,COG0787@2|Bacteria,1TNYY@1239|Firmicutes,2480T@186801|Clostridia,260IY@186807|Peptococcaceae 186801|Clostridia M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids alr - 5.1.1.1 ko:K01775 ko00473,ko01100,ko01502,map00473,map01100,map01502 - R00401 RC00285 ko00000,ko00001,ko01000,ko01011 - - - Ala_racemase_C,Ala_racemase_N SRD1_k127_75397_2 1191523.MROS_0727 1.256e-80 277.0 COG0436@1|root,COG0436@2|Bacteria 2|Bacteria E Aminotransferase - - - ko:K21572 - - - - ko00000,ko02000 8.A.46.1,8.A.46.3 - - SusD-like_3,SusD_RagB SRD1_k127_75397_1 945713.IALB_0269 2.042e-137 447.0 COG3239@1|root,COG3239@2|Bacteria 2|Bacteria I unsaturated fatty acid biosynthetic process - - 1.14.18.5,1.14.19.17 ko:K04712 ko00600,ko01100,ko04071,map00600,map01100,map04071 M00094,M00099 R06519 RC00824 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FA_desaturase,Lipid_DES SRD1_k127_75397_0 313606.M23134_04351 9.129e-215 691.0 COG0460@1|root,COG0527@1|root,COG0460@2|Bacteria,COG0527@2|Bacteria,4NFGR@976|Bacteroidetes,47KEQ@768503|Cytophagia 976|Bacteroidetes E TIGRFAM Aspartate kinase thrA - 1.1.1.3,2.7.2.4 ko:K12524 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00017,M00018,M00526,M00527 R00480,R01773,R01775 RC00002,RC00043,RC00087 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,ACT,ACT_7,Homoserine_dh,NAD_binding_3 SRD1_k127_754549_2 1321778.HMPREF1982_00297 6.727e-48 179.0 COG0280@1|root,COG0280@2|Bacteria,1TRQU@1239|Firmicutes,24857@186801|Clostridia,26A91@186813|unclassified Clostridiales 186801|Clostridia C Phosphate acetyl/butaryl transferase ptb GO:0003674,GO:0003824,GO:0016740,GO:0016746,GO:0016747,GO:0050182 2.3.1.19 ko:K00634 ko00650,ko01100,map00650,map01100 - R01174 RC00004,RC02816 ko00000,ko00001,ko01000 - - - PTA_PTB SRD1_k127_754549_1 1408422.JHYF01000003_gene655 9.81e-107 359.0 COG3426@1|root,COG3426@2|Bacteria,1TPKE@1239|Firmicutes,24993@186801|Clostridia,36EWW@31979|Clostridiaceae 186801|Clostridia C Belongs to the acetokinase family buk2 - 2.7.2.7 ko:K00929 ko00650,ko01100,map00650,map01100 - R01688 RC00002,RC00043 ko00000,ko00001,ko01000 - - - Acetate_kinase SRD1_k127_754549_4 945713.IALB_2041 3.611e-31 126.0 COG0537@1|root,COG0537@2|Bacteria 945713.IALB_2041|- FG bis(5'-adenosyl)-triphosphatase activity - - - ko:K02503 - - - - ko00000,ko04147 - - - - SRD1_k127_754549_0 1519464.HY22_01095 2.288e-204 646.0 COG0538@1|root,COG0538@2|Bacteria 2|Bacteria C isocitrate dehydrogenase activity icd GO:0003674,GO:0003824,GO:0003862,GO:0004448,GO:0004450,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006520,GO:0006551,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0022900,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0050896,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - e_coli_core.b1136,iAF1260.b1136,iECDH1ME8569_1439.ECDH1ME8569_1071,iEcDH1_1363.EcDH1_2511,iJN746.PP_4011,iJO1366.b1136,iJR904.b1136,iY75_1357.Y75_RS05930,iYL1228.KPN_01144 Iso_dh SRD1_k127_754549_3 324057.Pjdr2_5145 1.266e-45 170.0 28NYH@1|root,2ZBVN@2|Bacteria,1V1T3@1239|Firmicutes,4HHZS@91061|Bacilli,26WPV@186822|Paenibacillaceae 91061|Bacilli S Belongs to the UPF0403 family yphP - - - - - - - - - - - Disulph_isomer SRD1_k127_7555360_0 1185876.BN8_04086 5.237e-31 140.0 COG4447@1|root,COG4447@2|Bacteria,4NTT3@976|Bacteroidetes,47T1M@768503|Cytophagia 976|Bacteroidetes S cellulose binding - - - - - - - - - - - - - SRD1_k127_7557092_2 1146883.BLASA_0343 4.624e-26 114.0 COG0438@1|root,COG0438@2|Bacteria,2GNR8@201174|Actinobacteria,4EW89@85013|Frankiales 201174|Actinobacteria M Glycosyl transferases group 1 - - - ko:K19424 - - - - ko00000,ko01000,ko01003 - GT4 - Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 SRD1_k127_7557092_1 756883.Halar_0599 4.7e-37 153.0 COG1216@1|root,arCOG01383@2157|Archaea 2157|Archaea M PFAM Glycosyl transferase family 2 - - - ko:K07011 - - - - ko00000 - - - Glycos_transf_2 SRD1_k127_7557092_0 697282.Mettu_3899 1.021e-56 211.0 COG1216@1|root,COG1216@2|Bacteria,1NM61@1224|Proteobacteria,1RRUD@1236|Gammaproteobacteria,1XFCW@135618|Methylococcales 135618|Methylococcales S Glycosyl transferase - - - ko:K07011 - - - - ko00000 - - - Glycos_transf_2 SRD1_k127_7557092_3 585425.KR52_10525 9.326e-12 71.0 COG1216@1|root,COG1216@2|Bacteria,1G1PB@1117|Cyanobacteria,1GYWI@1129|Synechococcus 1117|Cyanobacteria S glycosyl transferase wcaA - - - - - - - - - - - Glycos_transf_2 SRD1_k127_7571742_6 333138.LQ50_05755 3.571e-16 81.0 COG1983@1|root,COG1983@2|Bacteria,1VKBQ@1239|Firmicutes,4HRGW@91061|Bacilli,1ZJCV@1386|Bacillus 91061|Bacilli KT PspC domain yvlC - - ko:K03973 - - - - ko00000,ko02048,ko03000 - - - DUF4097,PspC SRD1_k127_7571742_2 1089547.KB913013_gene1586 4.735e-36 141.0 COG0234@1|root,COG0234@2|Bacteria,4NRE1@976|Bacteroidetes,47Q9W@768503|Cytophagia 976|Bacteroidetes O Chaperonin 10 Kd subunit - - - - - - - - - - - - Cpn10 SRD1_k127_7571742_0 945713.IALB_0026 4.962e-182 575.0 COG1830@1|root,COG1830@2|Bacteria 2|Bacteria G lyase activity fbaB GO:0003674,GO:0003824,GO:0004332,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016829,GO:0016830,GO:0016832,GO:0042802,GO:0044424,GO:0044444,GO:0044464 4.1.2.13 ko:K11645 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 - - iETEC_1333.ETEC_2236,iSBO_1134.SBO_0918,iUMNK88_1353.UMNK88_2640 DeoC SRD1_k127_7571742_5 1122243.KB903793_gene1839 1.097e-24 105.0 COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,1SCA7@1236|Gammaproteobacteria,3NPC2@468|Moraxellaceae 1236|Gammaproteobacteria K 'Cold-shock' DNA-binding domain capB - - ko:K03704 - - - - ko00000,ko03000 - - - CSD SRD1_k127_7571742_3 717605.Theco_1796 8.433e-34 141.0 COG0388@1|root,COG0388@2|Bacteria,1TQDK@1239|Firmicutes,4HC44@91061|Bacilli,26QCB@186822|Paenibacillaceae 91061|Bacilli S Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase mtnU - 3.5.1.3 ko:K13566 ko00250,map00250 - R00269,R00348 RC00010 ko00000,ko00001,ko01000 - - - CN_hydrolase SRD1_k127_7571742_1 1196324.A374_09663 1.38e-36 153.0 COG0780@1|root,COG0780@2|Bacteria,1TPYC@1239|Firmicutes,4HB14@91061|Bacilli 91061|Bacilli S Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily queF - 1.7.1.13 ko:K09457 ko00790,ko01100,map00790,map01100 - R07605 RC01875 ko00000,ko00001,ko01000,ko03016 - - - QueF SRD1_k127_7571742_4 318167.Sfri_0463 1.946e-27 122.0 COG0526@1|root,COG0526@2|Bacteria,1NAHI@1224|Proteobacteria,1SCND@1236|Gammaproteobacteria,2QB1H@267890|Shewanellaceae 1236|Gammaproteobacteria CO Thioredoxin - - - - - - - - - - - - Thioredoxin,Thioredoxin_9 SRD1_k127_7571742_7 1122603.ATVI01000005_gene3498 4.245e-14 87.0 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1SZ6C@1236|Gammaproteobacteria,1XCCV@135614|Xanthomonadales 1236|Gammaproteobacteria T Tetratricopeptide repeat - - - - - - - - - - - - Guanylate_cyc,TPR_19,TPR_2,TPR_8 SRD1_k127_7571742_8 869210.Marky_0727 1.43e-13 79.0 COG0558@1|root,COG0558@2|Bacteria,1WIUS@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus I Belongs to the CDP-alcohol phosphatidyltransferase class-I family - - - - - - - - - - - - CDP-OH_P_transf SRD1_k127_7579403_5 1173028.ANKO01000075_gene2953 1.142e-10 68.0 COG2062@1|root,COG2062@2|Bacteria,1G6QD@1117|Cyanobacteria,1HBRK@1150|Oscillatoriales 1117|Cyanobacteria T Phosphohistidine phosphatase, SixA sixA - - ko:K08296 - - - - ko00000,ko01000 - - - His_Phos_1 SRD1_k127_7579403_2 926569.ANT_03540 5.655e-68 235.0 COG1839@1|root,COG1839@2|Bacteria,2G6BH@200795|Chloroflexi 200795|Chloroflexi S Adenosine specific kinase - - - ko:K09129 - - - - ko00000 - - - Adenosine_kin SRD1_k127_7579403_1 502025.Hoch_5836 3.799e-125 415.0 COG2355@1|root,COG2355@2|Bacteria,1MWEW@1224|Proteobacteria,42NXB@68525|delta/epsilon subdivisions,2WMBF@28221|Deltaproteobacteria,2YXC1@29|Myxococcales 28221|Deltaproteobacteria E Membrane dipeptidase (Peptidase family M19) - - 3.4.13.19 ko:K01273 - - - - ko00000,ko00537,ko01000,ko01002,ko04147 - - - Peptidase_M19 SRD1_k127_7579403_0 945713.IALB_0783 8.677e-278 864.0 COG2987@1|root,COG2987@2|Bacteria 2|Bacteria E urocanate hydratase activity hutU GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006547,GO:0006548,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009987,GO:0016054,GO:0016153,GO:0016829,GO:0016835,GO:0016836,GO:0019439,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046395,GO:0046483,GO:0046700,GO:0052803,GO:0052805,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 4.2.1.49 ko:K01712 ko00340,ko01100,map00340,map01100 M00045 R02914 RC00804 ko00000,ko00001,ko00002,ko01000 - - iECIAI39_1322.ECIAI39_0688 Urocanase,Urocanase_C,Urocanase_N SRD1_k127_7579403_3 1385521.N803_10245 1.485e-17 89.0 COG3324@1|root,COG3324@2|Bacteria,2IRXF@201174|Actinobacteria,4FH0J@85021|Intrasporangiaceae 201174|Actinobacteria S glyoxalase bleomycin resistance protein dioxygenase - - - ko:K06996 - - - - ko00000 - - - Glyoxalase SRD1_k127_7579403_4 479433.Caci_1944 1.505e-11 67.0 2DG6U@1|root,2ZURF@2|Bacteria,2HCGM@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - SRD1_k127_7595937_6 331869.BAL199_10435 4.176e-09 60.0 COG0756@1|root,COG0756@2|Bacteria,1RA7P@1224|Proteobacteria,2U7B5@28211|Alphaproteobacteria,4BQCP@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA dut GO:0000287,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.6.1.23 ko:K01520 ko00240,ko00983,ko01100,map00240,map00983,map01100 M00053 R02100,R11896 RC00002 ko00000,ko00001,ko00002,ko01000,ko03400 - - - dUTPase SRD1_k127_7595937_0 518766.Rmar_2160 5.078e-187 592.0 COG1894@1|root,COG1894@2|Bacteria,4NFB5@976|Bacteroidetes,1FJ3D@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes C NADH-ubiquinone oxidoreductase-F iron-sulfur binding region hndC - 1.12.1.3,1.6.5.3 ko:K00335,ko:K18331 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB SRD1_k127_7595937_5 9031.ENSGALP00000023091 7.834e-45 168.0 COG1905@1|root,KOG3196@2759|Eukaryota,38G5A@33154|Opisthokonta,3BI24@33208|Metazoa,3CSRY@33213|Bilateria,48532@7711|Chordata,48WTW@7742|Vertebrata,4GPG6@8782|Aves 33208|Metazoa C NADH dehydrogenase (ubiquinone) flavoprotein 2 NDUFV2 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005746,GO:0005747,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006996,GO:0007005,GO:0007275,GO:0007399,GO:0007507,GO:0008137,GO:0008150,GO:0008152,GO:0009055,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009888,GO:0009987,GO:0010257,GO:0014706,GO:0015980,GO:0016020,GO:0016043,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0019866,GO:0022607,GO:0022900,GO:0022904,GO:0030964,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0032501,GO:0032502,GO:0032981,GO:0032991,GO:0033108,GO:0034622,GO:0034641,GO:0042773,GO:0042775,GO:0043209,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044281,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0045271,GO:0045333,GO:0046034,GO:0046483,GO:0048513,GO:0048731,GO:0048738,GO:0048856,GO:0050136,GO:0055086,GO:0055114,GO:0060537,GO:0065003,GO:0070469,GO:0071704,GO:0071840,GO:0072359,GO:0072521,GO:0098796,GO:0098798,GO:0098800,GO:0098803,GO:1901135,GO:1901360,GO:1901564,GO:1902494,GO:1990204 1.6.5.3,1.6.99.3 ko:K03943 ko00190,ko01100,ko04714,ko04723,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04714,map04723,map04932,map05010,map05012,map05016 M00143 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1.6 - - 2Fe-2S_thioredx SRD1_k127_7595937_1 945713.IALB_2121 3.213e-181 575.0 COG0649@1|root,COG0649@2|Bacteria 2|Bacteria C NAD binding nuoD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0016020,GO:0044424,GO:0044464,GO:0071944 1.6.5.3 ko:K00333,ko:K13378 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_30kDa,Complex1_49kDa SRD1_k127_7595937_4 518766.Rmar_2154 7.722e-48 177.0 COG0852@1|root,COG0852@2|Bacteria,4NPZH@976|Bacteroidetes,1FIYC@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoC - 1.6.5.3 ko:K00332 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_30kDa SRD1_k127_7595937_3 945713.IALB_2123 1.054e-75 259.0 COG0377@1|root,COG0377@2|Bacteria 2|Bacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoB - 1.6.5.3 ko:K00331 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q6 SRD1_k127_7595937_2 1519464.HY22_10785 1.132e-86 293.0 COG1022@1|root,COG1022@2|Bacteria,1FDU1@1090|Chlorobi 1090|Chlorobi I PFAM AMP-dependent synthetase and ligase - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding SRD1_k127_7616704_2 945713.IALB_1147 7.078e-55 198.0 COG2301@1|root,COG3052@1|root,COG2301@2|Bacteria,COG3052@2|Bacteria 2|Bacteria C prosthetic group binding citD GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006091,GO:0006113,GO:0008150,GO:0008152,GO:0008815,GO:0009346,GO:0009987,GO:0015980,GO:0016829,GO:0016830,GO:0016833,GO:0032991,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0055114 4.1.3.25,4.1.3.34 ko:K01644,ko:K01646,ko:K18292 ko00660,ko01100,ko02020,map00660,map01100,map02020 - R00237,R00362 RC00067,RC00502,RC01118,RC01205 ko00000,ko00001,ko01000 - - - ACP,HpcH_HpaI SRD1_k127_7616704_1 373903.Hore_04650 2.753e-122 404.0 COG1397@1|root,COG1397@2|Bacteria,1TQXG@1239|Firmicutes,24C2X@186801|Clostridia,3WBZS@53433|Halanaerobiales 186801|Clostridia O ADP-ribosylation Crystallin J1 - - - - - - - - - - - - ADP_ribosyl_GH SRD1_k127_7616704_0 373903.Hore_04640 9.87e-153 499.0 COG1397@1|root,COG1397@2|Bacteria,1TSKF@1239|Firmicutes,25DA4@186801|Clostridia 186801|Clostridia O ADP-ribosylglycohydrolase - - - - - - - - - - - - ADP_ribosyl_GH SRD1_k127_7616704_3 373903.Hore_04630 6.128e-21 96.0 COG1397@1|root,COG1397@2|Bacteria,1UZ68@1239|Firmicutes,24CKK@186801|Clostridia 186801|Clostridia O ADP-ribosylglycohydrolase - - - - - - - - - - - - ADP_ribosyl_GH SRD1_k127_7627264_2 1032480.MLP_44770 1.003e-27 119.0 COG0248@1|root,COG0248@2|Bacteria,2GJBN@201174|Actinobacteria,4DQ85@85009|Propionibacteriales 201174|Actinobacteria FP Ppx/GppA phosphatase family ppx - 3.6.1.11,3.6.1.40 ko:K01524 ko00230,map00230 - R03409 RC00002 ko00000,ko00001,ko01000 - - - Ppx-GppA SRD1_k127_7627264_1 518766.Rmar_2327 3.139e-66 237.0 COG2264@1|root,COG2264@2|Bacteria,4NFRW@976|Bacteroidetes,1FJAA@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes J Ribosomal protein L11 methyltransferase (PrmA) prmA - - ko:K02687 - - - - ko00000,ko01000,ko03009 - - - PrmA SRD1_k127_7627264_0 880073.Calab_0186 3.539e-82 284.0 COG2234@1|root,COG2234@2|Bacteria,2NP7A@2323|unclassified Bacteria 2|Bacteria S Peptidase M28 ywaD - - - - - - - - - - - Peptidase_M28 SRD1_k127_7664377_0 1123248.KB893314_gene3562 2.563e-137 450.0 COG1030@1|root,COG1030@2|Bacteria,4NGGV@976|Bacteroidetes,1IPJY@117747|Sphingobacteriia 976|Bacteroidetes O NfeD-like C-terminal, partner-binding - - - ko:K07403 - - - - ko00000 - - - CLP_protease,NfeD SRD1_k127_7664377_1 700598.Niako_6329 1.475e-70 242.0 COG0330@1|root,COG0330@2|Bacteria,4NFPK@976|Bacteroidetes,1IRDU@117747|Sphingobacteriia 976|Bacteroidetes O PFAM SPFH domain Band 7 family - - - - - - - - - - - - Band_7 SRD1_k127_7673143_1 945713.IALB_1569 1.018e-53 199.0 COG0739@1|root,COG0739@2|Bacteria 2|Bacteria M heme binding - - - ko:K21471 - - - - ko00000,ko01000,ko01002,ko01011 - - - LysM,Peptidase_M23,SH3_3 SRD1_k127_7673143_3 1191523.MROS_2539 1.357e-33 130.0 2C8VT@1|root,32RN1@2|Bacteria 2|Bacteria S Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - DUF2795 SRD1_k127_7673143_0 1191523.MROS_1692 1.693e-71 268.0 COG4775@1|root,COG4775@2|Bacteria 2|Bacteria M membrane organization - - - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA,POTRA_2 SRD1_k127_7673143_2 518766.Rmar_2254 5.782e-47 181.0 COG2812@1|root,COG2812@2|Bacteria,4PKEA@976|Bacteroidetes,1FJ1I@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes L DNA polymerase III, delta subunit - - 2.7.7.7 ko:K02341 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2 SRD1_k127_7676240_0 1173024.KI912148_gene4055 2.716e-73 259.0 COG3975@1|root,COG3975@2|Bacteria,1G0YP@1117|Cyanobacteria,1JJDG@1189|Stigonemataceae 1117|Cyanobacteria S M61 glycyl aminopeptidase - - - - - - - - - - - - PDZ_2,Peptidase_M61 SRD1_k127_7676240_1 880073.Calab_0674 4.289e-20 105.0 COG1520@1|root,COG2911@1|root,COG3420@1|root,COG1520@2|Bacteria,COG2911@2|Bacteria,COG3420@2|Bacteria 2|Bacteria P alginic acid biosynthetic process - - 4.2.2.3 ko:K01729,ko:K17713 ko00051,map00051 - R03706 - ko00000,ko00001,ko01000,ko02000 1.B.33.1 - - Beta_helix,Big_4,CHU_C,CarboxypepD_reg,DUF5050,HYR,Peptidase_S8,SprB SRD1_k127_7679908_1 215803.DB30_7421 5.773e-24 109.0 COG1164@1|root,COG1164@2|Bacteria,1Q3C4@1224|Proteobacteria,4393F@68525|delta/epsilon subdivisions,2X49B@28221|Deltaproteobacteria,2YYJ7@29|Myxococcales 28221|Deltaproteobacteria E Oligoendopeptidase f - - - - - - - - - - - - - SRD1_k127_7679908_0 204669.Acid345_0515 0.0 1307.0 COG4447@1|root,COG4447@2|Bacteria,3Y487@57723|Acidobacteria 57723|Acidobacteria S cellulose binding - - - - - - - - - - - - Sortilin-Vps10 SRD1_k127_7685683_3 556261.HMPREF0240_01243 1.642e-08 58.0 COG0407@1|root,COG0407@2|Bacteria,1TSSK@1239|Firmicutes,24CHA@186801|Clostridia,36VVK@31979|Clostridiaceae 186801|Clostridia H Uroporphyrinogen decarboxylase (URO-D) - - - - - - - - - - - - URO-D SRD1_k127_7685683_0 1124780.ANNU01000077_gene789 3.272e-134 445.0 COG0477@1|root,COG0477@2|Bacteria,4PKTJ@976|Bacteroidetes,47YD9@768503|Cytophagia 976|Bacteroidetes EGP Sugar (and other) transporter - - - ko:K08138 - - - - ko00000,ko02000 2.A.1.1.3 - - Sugar_tr SRD1_k127_7685683_2 1487953.JMKF01000080_gene4215 5.462e-12 75.0 2DZFE@1|root,32V9B@2|Bacteria,1G8M5@1117|Cyanobacteria,1HGB8@1150|Oscillatoriales 1117|Cyanobacteria - - - - - - - - - - - - - - - SRD1_k127_7685683_1 1121106.JQKB01000008_gene1471 5.606e-23 98.0 COG2261@1|root,COG2261@2|Bacteria,1N72W@1224|Proteobacteria,2UBU4@28211|Alphaproteobacteria,2JTUG@204441|Rhodospirillales 204441|Rhodospirillales S Transglycosylase associated protein - - - - - - - - - - - - Transgly_assoc SRD1_k127_7695195_3 1121899.Q764_03275 1.052e-11 77.0 COG1452@1|root,COG1452@2|Bacteria,4NDU3@976|Bacteroidetes,1HWTD@117743|Flavobacteriia,2NUFT@237|Flavobacterium 976|Bacteroidetes M OstA-like protein - - - - - - - - - - - - OstA,OstA_2 SRD1_k127_7695195_0 945713.IALB_1891 2.128e-112 367.0 COG1137@1|root,COG1137@2|Bacteria 2|Bacteria S lipopolysaccharide-transporting ATPase activity lptB GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015221,GO:0015399,GO:0015405,GO:0015437,GO:0015920,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0032991,GO:0033036,GO:0034040,GO:0042623,GO:0042626,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1901264,GO:1901505,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - ko:K01990,ko:K06861 ko02010,map02010 M00254,M00320 - - ko00000,ko00001,ko00002,ko01000,ko02000 1.B.42.1,3.A.1 - - ABC_tran,BCA_ABC_TP_C SRD1_k127_7695195_4 1382359.JIAL01000001_gene378 4.577e-05 51.0 2EQAC@1|root,33HWH@2|Bacteria,3Y5W6@57723|Acidobacteria 57723|Acidobacteria - - - - - - - - - - - - - - - SRD1_k127_7695195_2 452637.Oter_3821 2.261e-18 89.0 COG2331@1|root,COG2331@2|Bacteria,46T2S@74201|Verrucomicrobia 74201|Verrucomicrobia S Putative regulatory protein - - - - - - - - - - - - Zn-ribbon_8 SRD1_k127_7695195_1 498761.HM1_1327 1.841e-31 127.0 COG0436@1|root,COG0436@2|Bacteria,1TP0J@1239|Firmicutes,247NQ@186801|Clostridia 186801|Clostridia E PFAM aminotransferase class I and II aspB - 2.6.1.1 ko:K00812,ko:K10907 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 - - iHN637.CLJU_RS06550 Aminotran_1_2 SRD1_k127_7700012_0 880073.Calab_3803 2.199e-91 316.0 COG2067@1|root,COG2067@2|Bacteria 2|Bacteria I long-chain fatty acid transporting porin activity - - - - - - - - - - - - - SRD1_k127_7700012_1 945713.IALB_1002 7.903e-40 163.0 COG3292@1|root,COG3292@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - GAF_2,GGDEF,HATPase_c,HisKA,HisKA_3,Hpt,Reg_prop,Response_reg,Y_Y_Y SRD1_k127_7708231_2 945713.IALB_2875 4.397e-31 135.0 COG4726@1|root,COG4726@2|Bacteria 2|Bacteria NU Pilus assembly protein PilX - - - ko:K02673 - - - - ko00000,ko02035,ko02044 - - - DUF4900,PilX_N SRD1_k127_7708231_4 945713.IALB_2874 3.347e-25 113.0 2DGVS@1|root,2ZXFY@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - SRD1_k127_7708231_0 234267.Acid_7115 6.89e-213 679.0 COG0646@1|root,COG0685@1|root,COG0646@2|Bacteria,COG0685@2|Bacteria,3Y3YD@57723|Acidobacteria 57723|Acidobacteria E homocysteine S-methyltransferase - - 1.5.1.20,2.1.1.10 ko:K00297,ko:K00547 ko00270,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01523,map00270,map00670,map00720,map01100,map01110,map01120,map01200,map01523 M00377 R00650,R01224,R07168 RC00003,RC00035,RC00081 ko00000,ko00001,ko00002,ko01000 - - - MTHFR,S-methyl_trans SRD1_k127_7708231_1 215803.DB30_7234 4.093e-145 468.0 COG0667@1|root,COG0667@2|Bacteria,1MVEH@1224|Proteobacteria,42MDR@68525|delta/epsilon subdivisions,2WKUR@28221|Deltaproteobacteria,2YU5C@29|Myxococcales 28221|Deltaproteobacteria C Aldo/keto reductase family - - - - - - - - - - - - Aldo_ket_red SRD1_k127_7708231_5 323848.Nmul_A1650 2.893e-24 112.0 COG0730@1|root,COG0730@2|Bacteria,1RBHH@1224|Proteobacteria,2VU9J@28216|Betaproteobacteria 28216|Betaproteobacteria S Sulfite exporter TauE/SafE - - - ko:K07090 - - - - ko00000 - - - TauE SRD1_k127_7708231_3 1550091.JROE01000002_gene587 4.56e-28 126.0 COG1164@1|root,COG1164@2|Bacteria,4NFYH@976|Bacteroidetes 976|Bacteroidetes E TIGRFAM oligoendopeptidase, M3 family pepF - - ko:K08602 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M3,Peptidase_M3_N SRD1_k127_7736399_6 373903.Hore_04630 2.494e-23 102.0 COG1397@1|root,COG1397@2|Bacteria,1UZ68@1239|Firmicutes,24CKK@186801|Clostridia 186801|Clostridia O ADP-ribosylglycohydrolase - - - - - - - - - - - - ADP_ribosyl_GH SRD1_k127_7736399_2 373903.Hore_04620 2.021e-93 318.0 COG1397@1|root,COG1397@2|Bacteria,1TQXG@1239|Firmicutes,24C2X@186801|Clostridia,3WBZS@53433|Halanaerobiales 186801|Clostridia O ADP-ribosylation Crystallin J1 - - - - - - - - - - - - ADP_ribosyl_GH SRD1_k127_7736399_0 373903.Hore_04610 1.906e-150 487.0 COG1653@1|root,COG1653@2|Bacteria 2|Bacteria G carbohydrate transport - - - ko:K02027,ko:K17311 ko02010,map02010 M00207,M00604 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.15 - - SBP_bac_1 SRD1_k127_7736399_3 373903.Hore_04600 1.302e-88 308.0 COG0395@1|root,COG0395@2|Bacteria,1TRXW@1239|Firmicutes,24JR6@186801|Clostridia 186801|Clostridia P Binding-protein-dependent transport system inner membrane component - - - ko:K02026 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 SRD1_k127_7736399_1 373903.Hore_04590 6.926e-109 361.0 COG1175@1|root,COG1175@2|Bacteria,1TTAF@1239|Firmicutes,24E6U@186801|Clostridia 186801|Clostridia P Binding-protein-dependent transport system inner membrane component - - - ko:K02025 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 SRD1_k127_7736399_5 1123508.JH636439_gene1115 2.438e-57 222.0 COG1680@1|root,COG1680@2|Bacteria 2|Bacteria V peptidase activity - - - - - - - - - - - - Beta-lactamase SRD1_k127_7736399_7 665571.STHERM_c14610 5.099e-19 101.0 COG4099@1|root,COG4099@2|Bacteria 2|Bacteria F phospholipase Carboxylesterase - - - - - - - - - - - - Abhydrolase_2,Esterase_phd,Peptidase_S9 SRD1_k127_7736399_4 1268622.AVS7_02480 4.274e-74 267.0 COG2374@1|root,COG3055@1|root,COG3391@1|root,COG2374@2|Bacteria,COG3055@2|Bacteria,COG3391@2|Bacteria 2|Bacteria CO amine dehydrogenase activity - - - ko:K07004 - - - - ko00000 - - - DUF3616,Exo_endo_phos,NHL SRD1_k127_776573_4 309801.trd_1666 2.339e-53 190.0 COG0648@1|root,COG0648@2|Bacteria,2G5XZ@200795|Chloroflexi,27XEG@189775|Thermomicrobia 189775|Thermomicrobia L Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin nfo - 3.1.21.2 ko:K01151 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - AP_endonuc_2 SRD1_k127_776573_1 1337936.IJ00_10605 1.065e-107 364.0 COG1162@1|root,COG1162@2|Bacteria,1G18W@1117|Cyanobacteria,1HMV7@1161|Nostocales 1117|Cyanobacteria S One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit - - 3.1.3.100 ko:K06949 ko00730,ko01100,map00730,map01100 - R00615,R02135 RC00002,RC00017 ko00000,ko00001,ko01000,ko03009 - - - RsgA_GTPase SRD1_k127_776573_0 1379698.RBG1_1C00001G0798 2.611e-152 512.0 COG0308@1|root,COG1413@1|root,COG0308@2|Bacteria,COG1413@2|Bacteria,2NPGQ@2323|unclassified Bacteria 2|Bacteria E aminopeptidase pepN - 3.4.11.2 ko:K01256 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - HEAT_2,Peptidase_M1 SRD1_k127_776573_5 1191523.MROS_2812 1.791e-49 183.0 COG1259@1|root,COG3880@1|root,COG1259@2|Bacteria,COG3880@2|Bacteria 2|Bacteria E PFAM UvrB UvrC protein yqdE GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - ko:K03617,ko:K08999 - - - - ko00000 - - - DNase-RNase,UVR SRD1_k127_776573_2 945713.IALB_1844 3.805e-97 331.0 COG2025@1|root,COG2025@2|Bacteria 2|Bacteria C fatty acid beta-oxidation using acyl-CoA dehydrogenase etfA GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006091,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009055,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0019395,GO:0019752,GO:0022900,GO:0030258,GO:0032787,GO:0033539,GO:0034440,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071704,GO:0072329,GO:0097159,GO:1901265,GO:1901363,GO:1901575 - ko:K03522 - - - - ko00000,ko04147 - - - ETF,ETF_alpha SRD1_k127_776573_3 1191523.MROS_2810 2.248e-81 280.0 COG2086@1|root,COG2086@2|Bacteria 2|Bacteria C electron transfer activity etfB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016491,GO:0022900,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0055114 - ko:K03521 - - - - ko00000 - - - ETF SRD1_k127_776573_6 509635.N824_06610 6.017e-14 78.0 COG0268@1|root,COG0268@2|Bacteria,4NSB1@976|Bacteroidetes,1IYFW@117747|Sphingobacteriia 976|Bacteroidetes J Binds directly to 16S ribosomal RNA rpsT - - ko:K02968 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S20p SRD1_k127_7778287_3 1303518.CCALI_02706 3.508e-14 81.0 COG0383@1|root,COG0383@2|Bacteria 2|Bacteria G mannose metabolic process - - 3.2.1.24 ko:K01191 ko00511,map00511 - - - ko00000,ko00001,ko01000,ko04131 - GH38 - Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C SRD1_k127_7778287_0 661478.OP10G_1743 5.363e-134 437.0 COG3533@1|root,COG3533@2|Bacteria 2|Bacteria S Beta-L-arabinofuranosidase, GH127 - - - - - - - - - - - - Glyco_hydro_127,RicinB_lectin_2 SRD1_k127_7778287_1 661478.OP10G_1743 4.911e-86 294.0 COG3533@1|root,COG3533@2|Bacteria 2|Bacteria S Beta-L-arabinofuranosidase, GH127 - - - - - - - - - - - - Glyco_hydro_127,RicinB_lectin_2 SRD1_k127_7778287_2 1239962.C943_01006 3.153e-37 145.0 COG3408@1|root,COG3408@2|Bacteria,4NIK8@976|Bacteroidetes 976|Bacteroidetes G Trehalase - - - - - - - - - - - - Glyco_hydro_63,Trehalase SRD1_k127_7797787_5 1191523.MROS_2749 7.775e-15 77.0 COG0454@1|root,COG0456@2|Bacteria 2|Bacteria K acetyltransferase - - - - - - - - - - - - Acetyltransf_1 SRD1_k127_7797787_1 765420.OSCT_2753 3.545e-124 405.0 COG0115@1|root,COG0115@2|Bacteria,2G6AX@200795|Chloroflexi,3753Z@32061|Chloroflexia 32061|Chloroflexia E Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family - - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 SRD1_k127_7797787_4 1191523.MROS_2770 2.73e-39 156.0 COG0589@1|root,COG0589@2|Bacteria 2|Bacteria T AMP binding usp-3 - - - - - - - - - - - Usp SRD1_k127_7797787_2 1191523.MROS_0046 1.663e-119 392.0 COG0142@1|root,COG0142@2|Bacteria 2|Bacteria H isoprenoid biosynthetic process ispB GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009108,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0042180,GO:0042181,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901615,GO:1901617,GO:1901661,GO:1901663 2.5.1.30,2.5.1.90 ko:K00805,ko:K02523 ko00900,ko01110,map00900,map01110 - R09247,R09248 RC00279 ko00000,ko00001,ko01000,ko01006 - - iYL1228.KPN_03597,ic_1306.c3945 polyprenyl_synt SRD1_k127_7797787_3 945713.IALB_1458 5.239e-93 312.0 COG0805@1|root,COG0805@2|Bacteria 2|Bacteria U protein transport tatC GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0022804,GO:0022857,GO:0022884,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0042886,GO:0042887,GO:0043953,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680 - ko:K03118 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - TatC SRD1_k127_7797787_0 383372.Rcas_1155 8.667e-194 615.0 COG0112@1|root,COG0112@2|Bacteria,2G624@200795|Chloroflexi,3755R@32061|Chloroflexia 32061|Chloroflexia E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism glyA - 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 - - - SHMT SRD1_k127_7797787_6 1121094.KB894643_gene1780 9.039e-05 52.0 COG2067@1|root,COG2067@2|Bacteria,4NEP1@976|Bacteroidetes,2FN33@200643|Bacteroidia,4AKD6@815|Bacteroidaceae 976|Bacteroidetes I Psort location OuterMembrane, score - - - - - - - - - - - - Toluene_X SRD1_k127_7800777_1 880073.Calab_0661 6.736e-11 65.0 COG0042@1|root,COG0042@2|Bacteria,2NP3E@2323|unclassified Bacteria 2|Bacteria J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines dus - - ko:K05540 - - - - ko00000,ko01000,ko03016 - - - Dus SRD1_k127_7800777_0 1379698.RBG1_1C00001G1662 1.81e-105 353.0 COG3424@1|root,COG3424@2|Bacteria,2NPHJ@2323|unclassified Bacteria 2|Bacteria Q Chalcone and stilbene synthases, C-terminal domain bcsA GO:0003674,GO:0003824,GO:0016740,GO:0016746,GO:0016747 2.3.1.246 ko:K16424 ko01055,ko01130,map01055,map01130 - R06625 RC00004,RC02933 ko00000,ko00001,ko01000 - - - ACP_syn_III_C,Chal_sti_synt_C,Chal_sti_synt_N,FAE1_CUT1_RppA SRD1_k127_7800777_4 204669.Acid345_2759 0.000172 49.0 2E5J5@1|root,330AF@2|Bacteria,3Y5HZ@57723|Acidobacteria,2JJVY@204432|Acidobacteriia 204432|Acidobacteriia - - - - - - - - - - - - - - zinc_ribbon_2 SRD1_k127_7800777_2 717605.Theco_2704 5.713e-07 53.0 COG4758@1|root,COG4758@2|Bacteria,1VG3U@1239|Firmicutes,4HMA7@91061|Bacilli,26SC0@186822|Paenibacillaceae 91061|Bacilli S Cell wall-active antibiotics response 4TMS YvqF - - - ko:K11622 ko02020,map02020 - - - ko00000,ko00001 - - - DUF2154 SRD1_k127_7800777_3 871968.DESME_07340 0.000105 50.0 COG0633@1|root,COG3894@1|root,COG0633@2|Bacteria,COG3894@2|Bacteria,1TP0H@1239|Firmicutes,247S0@186801|Clostridia,260DA@186807|Peptococcaceae 186801|Clostridia C PFAM 2Fe-2S iron-sulfur cluster binding domain - - - - - - - - - - - - DUF4445,Fer2 SRD1_k127_7805561_3 880073.Calab_2433 3.026e-12 70.0 COG4775@1|root,COG4775@2|Bacteria 880073.Calab_2433|- M membrane organization - - - - - - - - - - - - - SRD1_k127_7805561_2 518766.Rmar_1925 7.785e-33 137.0 COG1385@1|root,COG1385@2|Bacteria,4NE2S@976|Bacteroidetes,1FJC7@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit rsmE - 2.1.1.193 ko:K09761 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_RNA SRD1_k127_7805561_1 460265.Mnod_7115 1.458e-48 182.0 COG3404@1|root,COG3404@2|Bacteria,1R781@1224|Proteobacteria,2TTRX@28211|Alphaproteobacteria,1JRH1@119045|Methylobacteriaceae 28211|Alphaproteobacteria E PFAM Formiminotransferase-cyclodeaminase - - - - - - - - - - - - FTCD_C SRD1_k127_7805561_0 1191523.MROS_0055 1.828e-118 390.0 COG3643@1|root,COG3643@2|Bacteria 2|Bacteria E Formiminotransferase domain ftcD - 2.1.2.5,4.3.1.4 ko:K00603,ko:K13990 ko00340,ko00670,ko01100,map00340,map00670,map01100 - R02287,R02302,R03189 RC00165,RC00221,RC00223,RC00688,RC00870 ko00000,ko00001,ko01000,ko03036,ko04147 - - - FTCD,FTCD_C,FTCD_N SRD1_k127_7809043_5 1121472.AQWN01000002_gene2269 1.544e-85 293.0 COG0151@1|root,COG0151@2|Bacteria,1UHN9@1239|Firmicutes,25E76@186801|Clostridia,2609N@186807|Peptococcaceae 186801|Clostridia F Belongs to the GARS family purD - 6.3.4.13 ko:K01945 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144 RC00090,RC00166 ko00000,ko00001,ko00002,ko01000 - - - GARS_A,GARS_C,GARS_N SRD1_k127_7809043_3 518766.Rmar_1322 3.349e-105 357.0 COG0438@1|root,COG0438@2|Bacteria,4NE6S@976|Bacteroidetes,1FIXH@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes M Glycosyltransferase Family 4 - - - - - - - - - - - - Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1 SRD1_k127_7809043_4 518766.Rmar_1321 1.019e-88 306.0 COG0006@1|root,COG0006@2|Bacteria,4NJI0@976|Bacteroidetes,1FIUI@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes E Creatinase/Prolidase N-terminal domain pepQ - 3.4.11.9,3.4.13.9 ko:K01262,ko:K01271 - - - - ko00000,ko01000,ko01002 - - - Creatinase_N,Peptidase_M24 SRD1_k127_7809043_0 945713.IALB_1778 6.847e-211 667.0 COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria 2|Bacteria S IMP dehydrogenase activity guaB GO:0003674,GO:0003824,GO:0003938,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0050896,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - iAPECO1_1312.APECO1_4018,iECABU_c1320.ECABU_c28100,iECP_1309.ECP_2510,iECSF_1327.ECSF_2349,iUTI89_1310.UTI89_C2826,ic_1306.c3027 CBS,IMPDH,NMO SRD1_k127_7809043_1 945713.IALB_1779 5.903e-189 598.0 COG1960@1|root,COG1960@2|Bacteria 2|Bacteria I acyl-CoA dehydrogenase activity gcdH GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 1.3.8.6 ko:K00252 ko00071,ko00310,ko00362,ko00380,ko01100,ko01120,ko01130,map00071,map00310,map00362,map00380,map01100,map01120,map01130 M00032 R02487,R02488,R10074 RC00052,RC00156 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N SRD1_k127_7809043_2 945713.IALB_0568 1.518e-131 433.0 COG2204@1|root,COG2204@2|Bacteria 2|Bacteria T phosphorelay signal transduction system - - - ko:K02481 - - - - ko00000,ko02022 - - - HTH_8,Response_reg,Sigma54_activat SRD1_k127_7809043_6 945713.IALB_0561 7.941e-27 117.0 COG2204@1|root,COG2204@2|Bacteria 2|Bacteria T phosphorelay signal transduction system - - - - - - - - - - - - HATPase_c,HTH_18,HisKA,Response_reg SRD1_k127_7820420_1 1205680.CAKO01000040_gene575 4.812e-142 456.0 COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria,1MVWY@1224|Proteobacteria,2TRSZ@28211|Alphaproteobacteria,2JQRY@204441|Rhodospirillales 204441|Rhodospirillales L DNA ligase - - 6.5.1.1 ko:K01971 ko03450,map03450 - R00381 RC00005 ko00000,ko00001,ko01000,ko03400 - - - DNA_ligase_A_C,DNA_ligase_A_M,LigD_N SRD1_k127_7820420_2 1205680.CAKO01000040_gene576 1.872e-92 312.0 COG1273@1|root,COG1273@2|Bacteria,1N4UX@1224|Proteobacteria,2TRTI@28211|Alphaproteobacteria,2JSVX@204441|Rhodospirillales 204441|Rhodospirillales L With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD ku - - ko:K10979 ko03450,map03450 - - - ko00000,ko00001,ko03400 - - - Ku SRD1_k127_7820420_3 357808.RoseRS_4263 1.382e-90 316.0 COG0438@1|root,COG0438@2|Bacteria,2G8JS@200795|Chloroflexi,3769Z@32061|Chloroflexia 32061|Chloroflexia H PFAM glycosyl transferase group 1 - - - - - - - - - - - - Glyco_trans_4_4,Glycos_transf_1 SRD1_k127_7820420_0 1123354.AUDR01000016_gene1414 5.122e-164 531.0 COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,2VHBY@28216|Betaproteobacteria,1KSJ0@119069|Hydrogenophilales 119069|Hydrogenophilales E Asparagine synthase - - - - - - - - - - - - Asn_synthase,GATase_7 SRD1_k127_7835320_0 1173023.KE650771_gene2046 2.501e-213 679.0 COG3280@1|root,COG3280@2|Bacteria,1G3IR@1117|Cyanobacteria,1JH6I@1189|Stigonemataceae 1117|Cyanobacteria G Alpha amylase, catalytic domain treY - 5.4.99.15 ko:K06044 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R01824,R09995 - ko00000,ko00001,ko00002,ko01000 - GH13 - Alpha-amylase SRD1_k127_7835320_1 118168.MC7420_6216 2.62e-98 335.0 COG0668@1|root,COG0668@2|Bacteria,1G08V@1117|Cyanobacteria,1H971@1150|Oscillatoriales 1117|Cyanobacteria M mechanosensitive ion channel mscS - - - - - - - - - - - MS_channel SRD1_k127_7839400_0 1121028.ARQE01000010_gene1033 3.971e-68 242.0 COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2TR49@28211|Alphaproteobacteria,2PJJY@255475|Aurantimonadaceae 28211|Alphaproteobacteria E Gamma-glutamyltranspeptidase ggt GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0006082,GO:0006508,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0008242,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016787,GO:0019538,GO:0019752,GO:0030288,GO:0030313,GO:0031975,GO:0034722,GO:0036374,GO:0042597,GO:0043094,GO:0043102,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0070011,GO:0071704,GO:0097264,GO:0140096,GO:1901564,GO:1901566,GO:1901576 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept SRD1_k127_7839400_1 204669.Acid345_2223 8.788e-44 165.0 COG0629@1|root,COG0629@2|Bacteria,3Y4D2@57723|Acidobacteria,2JJ18@204432|Acidobacteriia 204432|Acidobacteriia L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism - - - ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 - - - ko00000,ko00001,ko03029,ko03032,ko03400 - - - SSB SRD1_k127_7839400_2 945713.IALB_1364 2.321e-35 145.0 COG3391@1|root,COG3391@2|Bacteria 2|Bacteria CO amine dehydrogenase activity - - - - - - - - - - - - Cu_amine_oxidN1,DUF5128,NHL SRD1_k127_7880122_4 1519464.HY22_05725 1.307e-78 269.0 COG0497@1|root,COG0497@2|Bacteria,1FDSV@1090|Chlorobi 1090|Chlorobi L May be involved in recombinational repair of damaged DNA - - - ko:K03631 - - - - ko00000,ko03400 - - - SMC_N SRD1_k127_7880122_6 880073.Calab_0467 1.486e-36 153.0 COG1427@1|root,COG1427@2|Bacteria,2NRPR@2323|unclassified Bacteria 2|Bacteria S Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) mqnA - 1.21.98.1,4.2.1.151 ko:K07081,ko:K11782,ko:K11784 ko00130,ko01110,map00130,map01110 - R08588,R10666 RC02329,RC03232 ko00000,ko00001,ko01000 - - - VitK2_biosynth SRD1_k127_7880122_5 518766.Rmar_1031 8.764e-39 148.0 COG0335@1|root,COG0335@2|Bacteria,4NNPW@976|Bacteroidetes,1FJIG@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site rplS GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02884 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L19 SRD1_k127_7880122_2 1048983.EL17_19270 5.014e-88 296.0 COG0336@1|root,COG0336@2|Bacteria,4NF2Q@976|Bacteroidetes,47MGG@768503|Cytophagia 976|Bacteroidetes J Belongs to the RNA methyltransferase TrmD family trmD GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.228 ko:K00554 - - R00597 RC00003,RC00334 ko00000,ko01000,ko03016 - - - tRNA_m1G_MT SRD1_k127_7880122_8 1123288.SOV_1c11150 5.462e-30 127.0 COG0806@1|root,COG0806@2|Bacteria,1V6HD@1239|Firmicutes,4H56U@909932|Negativicutes 909932|Negativicutes J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes rimM - - ko:K02860 - - - - ko00000,ko03009 - - - PRC,RimM SRD1_k127_7880122_9 945713.IALB_0776 1.348e-20 94.0 COG1837@1|root,COG1837@2|Bacteria 2|Bacteria L Belongs to the UPF0109 family ylqC - - ko:K06960 - - - - ko00000 - - - KH_4 SRD1_k127_7880122_7 880073.Calab_2051 1.472e-31 130.0 COG0228@1|root,COG0228@2|Bacteria,2NPWN@2323|unclassified Bacteria 2|Bacteria J Belongs to the bacterial ribosomal protein bS16 family rpsP GO:0000028,GO:0000217,GO:0000400,GO:0003674,GO:0003676,GO:0003677,GO:0003735,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006259,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016787,GO:0016788,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02959 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_S16 SRD1_k127_7880122_1 880073.Calab_2050 6.159e-167 535.0 COG0541@1|root,COG0541@2|Bacteria,2NNT9@2323|unclassified Bacteria 2|Bacteria U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY ffh GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006605,GO:0006612,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0030312,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032991,GO:0033036,GO:0034613,GO:0035639,GO:0036094,GO:0040007,GO:0042886,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045184,GO:0046907,GO:0048500,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0070727,GO:0071702,GO:0071705,GO:0071944,GO:0072657,GO:0090150,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1990904 3.6.5.4 ko:K03106 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko01000,ko02044 3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9 - - SRP54,SRP54_N,SRP_SPB SRD1_k127_7880122_3 945713.IALB_0773 1.037e-80 278.0 COG0224@1|root,COG0224@2|Bacteria 2|Bacteria C proton-transporting ATP synthase activity, rotational mechanism atpG GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030312,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0040007,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - iLJ478.TM1611,iSSON_1240.SSON_3886,iYL1228.KPN_04138 ATP-synt SRD1_k127_7880122_0 1191523.MROS_0272 3.282e-222 697.0 COG0056@1|root,COG0056@2|Bacteria 2|Bacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0016469,GO:0030312,GO:0032991,GO:0040007,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045259,GO:0045260,GO:0071944,GO:0098796,GO:0098797 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - iSB619.SA_RS10975 ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N SRD1_k127_788282_2 234267.Acid_0398 4.098e-86 292.0 COG0509@1|root,COG0509@2|Bacteria 2|Bacteria E glycine decarboxylation via glycine cleavage system gcvH - - ko:K02437 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221 RC00022,RC02834 ko00000,ko00001,ko00002 - - - GCV_H,Response_reg SRD1_k127_788282_0 234267.Acid_0399 1.317e-190 607.0 COG5557@1|root,COG5557@2|Bacteria,3Y3RF@57723|Acidobacteria 2|Bacteria C Polysulphide reductase, NrfD qrcD - - ko:K00185 - - - - ko00000 5.A.3 - - NrfD SRD1_k127_788282_1 234267.Acid_0400 7.411e-99 330.0 COG0437@1|root,COG0437@2|Bacteria,3Y2Z0@57723|Acidobacteria 57723|Acidobacteria C 4Fe-4S dicluster domain - - - ko:K00184 - - - - ko00000 5.A.3 - - - SRD1_k127_788282_3 644282.Deba_2217 3.544e-30 136.0 COG0243@1|root,COG0243@2|Bacteria,1R4RR@1224|Proteobacteria,42PA5@68525|delta/epsilon subdivisions,2WM0K@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family qrcB - - ko:K08357 ko00920,ko01120,ko02020,map00920,map01120,map02020 - R10150 RC03109 ko00000,ko00001,ko02000 5.A.3.10 - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding SRD1_k127_7887781_1 518766.Rmar_0689 4.854e-129 428.0 COG3408@1|root,COG3408@2|Bacteria,4NESP@976|Bacteroidetes 976|Bacteroidetes G Alpha-L-rhamnosidase N-terminal domain - - 3.2.1.40 ko:K05989 - - - - ko00000,ko01000 - - - Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N SRD1_k127_7887781_0 63737.Npun_R2950 2.602e-175 558.0 COG2942@1|root,COG2942@2|Bacteria,1G04P@1117|Cyanobacteria,1HKN1@1161|Nostocales 1117|Cyanobacteria G PFAM N-acylglucosamine 2-epimerase - - 5.1.3.8 ko:K01787 ko00520,map00520 - R01207 RC00290 ko00000,ko00001,ko01000 - - - GlcNAc_2-epim SRD1_k127_7887781_2 886377.Murru_3346 2.057e-97 327.0 COG0477@1|root,COG2814@2|Bacteria,4NE09@976|Bacteroidetes,1HY74@117743|Flavobacteriia 976|Bacteroidetes EGP Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family araE - - ko:K02100 - - - - ko00000,ko02000 2.A.1.1.2 - - Sugar_tr SRD1_k127_7888712_1 1303518.CCALI_00534 2.49e-122 400.0 COG0031@1|root,COG0031@2|Bacteria 2|Bacteria E Belongs to the cysteine synthase cystathionine beta- synthase family cysM GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004124,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0019344,GO:0019752,GO:0019842,GO:0030170,GO:0032991,GO:0033847,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0080146,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.113,2.5.1.47 ko:K12339,ko:K21148 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04122,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230,map04122 M00021 R00897,R03132,R03601,R04859,R10610 RC00020,RC02814,RC02821,RC02876,RC03225 ko00000,ko00001,ko00002,ko01000 - - - PALP SRD1_k127_7888712_3 1040989.AWZU01000008_gene3647 1.027e-07 58.0 COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,3JTQ7@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Adenylate and Guanylate cyclase catalytic domain - - - - - - - - - - - - AAA_16,DZR,Guanylate_cyc,SAM_1 SRD1_k127_7888712_0 1267535.KB906767_gene451 3.424e-133 430.0 COG2897@1|root,COG2897@2|Bacteria 2|Bacteria P thiosulfate sulfurtransferase activity cysA2 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 2.8.1.1,2.8.1.2 ko:K01011 ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122 - R01931,R03105,R03106 RC00214 ko00000,ko00001,ko01000 - - - Rhodanese SRD1_k127_7888712_2 945713.IALB_1146 2.042e-70 240.0 COG3051@1|root,COG3051@2|Bacteria 2|Bacteria C citrate CoA-transferase activity citF - 2.8.3.10 ko:K01643 ko02020,map02020 - R00362 RC00067,RC01118 ko00000,ko00001,ko01000 - - - CitF SRD1_k127_7895872_2 518766.Rmar_2254 5.357e-26 115.0 COG2812@1|root,COG2812@2|Bacteria,4PKEA@976|Bacteroidetes,1FJ1I@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes L DNA polymerase III, delta subunit - - 2.7.7.7 ko:K02341 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2 SRD1_k127_7895872_0 945713.IALB_0460 1.133e-270 852.0 COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria 2|Bacteria J methionyl-tRNA aminoacylation metG GO:0003674,GO:0003824,GO:0004812,GO:0004825,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006431,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.10,6.1.1.20 ko:K01874,ko:K01890,ko:K06878 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R03660,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iEC042_1314.EC042_2346,iECUMN_1333.ECUMN_2446 Anticodon_1,tRNA-synt_1g,tRNA_bind SRD1_k127_7895872_1 1191523.MROS_1455 6.751e-138 453.0 COG0084@1|root,COG0535@1|root,COG0084@2|Bacteria,COG0535@2|Bacteria 2|Bacteria I radical SAM domain protein tatD - - ko:K03424 - - - - ko00000,ko01000 - - - Fer4_14,Radical_SAM,TatD_DNase SRD1_k127_7895872_3 1408813.AYMG01000010_gene553 2.305e-17 89.0 2C311@1|root,32RXX@2|Bacteria,4NUB7@976|Bacteroidetes,1ITSU@117747|Sphingobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - OMP_b-brl SRD1_k127_7895872_4 1408813.AYMG01000010_gene553 3.49e-12 71.0 2C311@1|root,32RXX@2|Bacteria,4NUB7@976|Bacteroidetes,1ITSU@117747|Sphingobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - OMP_b-brl SRD1_k127_7899557_4 1033732.CAHI01000029_gene1401 1.117e-24 112.0 COG0037@1|root,COG0037@2|Bacteria,4NEJS@976|Bacteroidetes,2FP2A@200643|Bacteroidia,22UBX@171550|Rikenellaceae 976|Bacteroidetes D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine tilS - 6.3.4.19 ko:K04075 - - R09597 RC02633,RC02634 ko00000,ko01000,ko03016 - - - ATP_bind_3,TilS_C SRD1_k127_7899557_2 945713.IALB_2403 2.276e-68 237.0 COG0634@1|root,COG0634@2|Bacteria 2|Bacteria F Belongs to the purine pyrimidine phosphoribosyltransferase family hpt GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.4.2.8,2.7.4.3,6.3.4.19 ko:K00760,ko:K00939,ko:K15780 ko00230,ko00730,ko00983,ko01100,ko01110,ko01130,map00230,map00730,map00983,map01100,map01110,map01130 M00049 R00127,R00190,R01132,R01229,R01547,R02142,R08237,R08238,R08245,R11319 RC00002,RC00063,RC00122 ko00000,ko00001,ko00002,ko01000,ko03016,ko04147 - - iHN637.CLJU_RS16720 ADK,Pribosyltran SRD1_k127_7899557_0 945713.IALB_2402 2.949e-289 904.0 COG0465@1|root,COG0465@2|Bacteria 2|Bacteria O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH GO:0000166,GO:0003674,GO:0003824,GO:0004175,GO:0004176,GO:0004222,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0008270,GO:0009056,GO:0009057,GO:0010468,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019222,GO:0019538,GO:0030145,GO:0030163,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043273,GO:0044238,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0098796,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 SRD1_k127_7899557_3 945713.IALB_2401 7.758e-52 197.0 COG0170@1|root,COG0170@2|Bacteria 2|Bacteria I dolichyl monophosphate biosynthetic process sec59 - 2.3.1.15 ko:K08591 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - G3P_acyltransf SRD1_k127_7899557_1 234267.Acid_4726 1.798e-73 252.0 COG0308@1|root,COG0308@2|Bacteria,3Y3ZS@57723|Acidobacteria 57723|Acidobacteria E Phospholipase B - - - - - - - - - - - - Phospholip_B SRD1_k127_7920534_1 1356852.N008_07175 2.438e-139 458.0 COG5267@1|root,COG5267@2|Bacteria,4NHSB@976|Bacteroidetes,47MD4@768503|Cytophagia 976|Bacteroidetes S Protein of unknown function (DUF1800) - - - - - - - - - - - - DUF1800 SRD1_k127_7920534_0 1356852.N008_07180 1.992e-152 498.0 COG4102@1|root,COG4102@2|Bacteria,4NFFC@976|Bacteroidetes,47MU2@768503|Cytophagia 976|Bacteroidetes S Protein of unknown function (DUF1501) - - - - - - - - - - - - DUF1501 SRD1_k127_7920534_3 1077972.ARGLB_113_00300 4.872e-09 65.0 COG4319@1|root,COG4319@2|Bacteria,2IHRK@201174|Actinobacteria 201174|Actinobacteria S SnoaL-like domain - - - - - - - - - - - - DUF4440,SnoaL_3 SRD1_k127_7920534_2 1408473.JHXO01000010_gene3676 7.996e-20 94.0 COG5434@1|root,COG5434@2|Bacteria,4NG4T@976|Bacteroidetes,2FNB1@200643|Bacteroidia 976|Bacteroidetes G Belongs to the glycosyl hydrolase 28 family - - - - - - - - - - - - Glyco_hydro_28 SRD1_k127_794395_0 1111069.TCCBUS3UF1_p80 2.178e-40 166.0 COG1988@1|root,COG1988@2|Bacteria,1WJBJ@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S membrane-bound metal-dependent - - - ko:K07038 - - - - ko00000 - - - YdjM SRD1_k127_794395_1 479434.Sthe_2631 2.219e-15 76.0 COG0506@1|root,COG0506@2|Bacteria,2G6B6@200795|Chloroflexi,27XF7@189775|Thermomicrobia 189775|Thermomicrobia C Proline dehydrogenase - - - ko:K00318 ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130 - R10507 RC00083 ko00000,ko00001,ko01000 - - - Pro_dh SRD1_k127_803142_1 880073.Calab_2972 8.126e-139 474.0 COG4774@1|root,COG4774@2|Bacteria 2|Bacteria P siderophore transport - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec SRD1_k127_803142_0 861299.J421_6272 5.937e-178 587.0 28MSW@1|root,2ZB15@2|Bacteria,1ZUI9@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - SRD1_k127_804357_0 1123248.KB893316_gene4587 1.57e-172 561.0 COG0457@1|root,COG0457@2|Bacteria,4NIBU@976|Bacteroidetes,1IQKQ@117747|Sphingobacteriia 976|Bacteroidetes S PFAM Tetratricopeptide - - - - - - - - - - - - DUF5107,TPR_16,TPR_8 SRD1_k127_804357_2 1519464.HY22_13130 2.966e-23 115.0 COG4102@1|root,COG4102@2|Bacteria 2|Bacteria S Protein of unknown function (DUF1501) - - - - - - - - - - - - DUF1501 SRD1_k127_804357_1 251221.35213714 2.005e-150 480.0 COG1164@1|root,COG1164@2|Bacteria 2|Bacteria E metalloendopeptidase activity - - 3.4.15.1 ko:K01283 ko04614,ko04924,ko05142,ko05410,map04614,map04924,map05142,map05410 - - - ko00000,ko00001,ko01000,ko01002,ko04090,ko04147 - - - Peptidase_M2,Peptidase_M3 SRD1_k127_820723_0 880073.Calab_0711 1.778e-287 903.0 COG0466@1|root,COG0466@2|Bacteria,2NNNN@2323|unclassified Bacteria 2|Bacteria O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C SRD1_k127_820723_1 1499967.BAYZ01000095_gene4149 2.84e-38 149.0 COG0071@1|root,COG0071@2|Bacteria,2NPWF@2323|unclassified Bacteria 2|Bacteria O Belongs to the small heat shock protein (HSP20) family - - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 SRD1_k127_820723_3 1191523.MROS_2419 5.709e-17 85.0 COG0071@1|root,COG0071@2|Bacteria 2|Bacteria O Belongs to the small heat shock protein (HSP20) family hspC1 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0006457,GO:0006950,GO:0006986,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0010033,GO:0033554,GO:0034605,GO:0034620,GO:0035966,GO:0035967,GO:0042221,GO:0042802,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044464,GO:0050896,GO:0051082,GO:0051716,GO:0051788,GO:0061077,GO:0070887,GO:0071218,GO:0071310 3.6.3.16 ko:K01551,ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko01000,ko02000,ko03110 3.A.19.1,3.A.21.1,3.A.4.1 - - ArsA_ATPase,HSP20 SRD1_k127_820723_2 1121918.ARWE01000001_gene2803 7.394e-24 106.0 COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,42U0T@68525|delta/epsilon subdivisions,2WRBN@28221|Deltaproteobacteria,43VIP@69541|Desulfuromonadales 28221|Deltaproteobacteria O Hsp20/alpha crystallin family hspA-2 - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 SRD1_k127_852557_2 1235803.C825_00983 1.737e-160 514.0 COG0477@1|root,COG2814@2|Bacteria,4NG5F@976|Bacteroidetes,2FPA7@200643|Bacteroidia,22WH2@171551|Porphyromonadaceae 976|Bacteroidetes EGP BT1 family - - - ko:K08218 ko01501,map01501 M00628 - - ko00000,ko00001,ko00002,ko02000 2.A.1.25 - - BT1,MFS_1 SRD1_k127_852557_1 1121129.KB903367_gene2695 1.978e-169 545.0 COG0463@1|root,COG0463@2|Bacteria,4NEQ9@976|Bacteroidetes,2G2IE@200643|Bacteroidia,22WXI@171551|Porphyromonadaceae 976|Bacteroidetes M Glycosyl transferase family 2 - - - - - - - - - - - - DUF4922,Glycos_transf_2,SpoIID SRD1_k127_852557_0 1191523.MROS_1177 1.453e-228 721.0 COG0442@1|root,COG0442@2|Bacteria 2|Bacteria J prolyl-tRNA aminoacylation proS GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iJN678.proS HGTP_anticodon,tRNA-synt_2b,tRNA_edit SRD1_k127_852557_3 330214.NIDE3974 2.673e-152 495.0 COG1012@1|root,COG1012@2|Bacteria,3J0YN@40117|Nitrospirae 40117|Nitrospirae C Aldehyde dehydrogenase family - - - - - - - - - - - - Aldedh SRD1_k127_891060_1 1038859.AXAU01000002_gene322 1.358e-42 169.0 COG0673@1|root,COG0673@2|Bacteria,1MUP0@1224|Proteobacteria,2TT57@28211|Alphaproteobacteria,3JSAU@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Oxidoreductase family, C-terminal alpha/beta domain - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C SRD1_k127_891060_0 517418.Ctha_2091 8.655e-50 183.0 COG0001@1|root,COG0001@2|Bacteria,1FETV@1090|Chlorobi 1090|Chlorobi H Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 SRD1_k127_90287_2 1499967.BAYZ01000185_gene4530 6.163e-87 314.0 COG5002@1|root,COG5002@2|Bacteria 2|Bacteria T protein histidine kinase activity - - 2.7.13.3 ko:K20974 ko02020,ko02025,map02020,map02025 M00820 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - GAF,HAMP,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,dCache_1 SRD1_k127_90287_3 386456.JQKN01000004_gene148 2.626e-71 267.0 COG0784@1|root,arCOG06537@2157|Archaea,2XWYJ@28890|Euryarchaeota 28890|Euryarchaeota T response regulator, receiver - - - - - - - - - - - - PAS,PAS_4,PAS_9,PadR,Response_reg SRD1_k127_90287_5 1390370.O203_01670 7.639e-09 64.0 COG0784@1|root,COG0784@2|Bacteria 2|Bacteria T Response regulator, receiver - - - - - - - - - - - - GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg SRD1_k127_90287_0 1210884.HG799467_gene13197 4.185e-135 458.0 COG4191@1|root,COG4191@2|Bacteria,2J25T@203682|Planctomycetes 203682|Planctomycetes T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,PAS_4,Response_reg SRD1_k127_90287_1 351160.RCIX1290 3.136e-102 357.0 COG2203@1|root,COG3920@1|root,arCOG02335@2157|Archaea,arCOG02357@2157|Archaea,2Y7UU@28890|Euryarchaeota,2NANW@224756|Methanomicrobia 224756|Methanomicrobia T SMART PAS domain containing protein - - - - - - - - - - - - GAF_2 SRD1_k127_90287_4 756067.MicvaDRAFT_2494 8.694e-29 134.0 COG2114@1|root,COG2202@1|root,COG2203@1|root,COG3447@1|root,COG2114@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG3447@2|Bacteria,1FZXP@1117|Cyanobacteria,1H71W@1150|Oscillatoriales 1117|Cyanobacteria T Belongs to the adenylyl cyclase class-4 guanylyl cyclase family - - - - - - - - - - - - GAF,Guanylate_cyc,HAMP,MASE1,PAS_9,dCache_1 SRD1_k127_90507_3 984262.SGRA_1051 3.521e-34 137.0 COG1145@1|root,COG1145@2|Bacteria,4NNF9@976|Bacteroidetes 976|Bacteroidetes C Ferredoxin fdx - - - - - - - - - - - Fer4,Fer4_7 SRD1_k127_90507_1 880073.Calab_0865 1.985e-87 298.0 COG0491@1|root,COG0491@2|Bacteria,2NPRD@2323|unclassified Bacteria 2|Bacteria S Metallo-beta-lactamase superfamily ytnP - - - - - - - - - - - Lactamase_B SRD1_k127_90507_4 945713.IALB_2268 2.503e-19 92.0 COG2146@1|root,COG2146@2|Bacteria 2|Bacteria P nitrite reductase [NAD(P)H] activity tmoC - - ko:K05710,ko:K15762,ko:K22360 ko00360,ko00623,ko00625,ko00920,ko01100,ko01120,ko01220,map00360,map00623,map00625,map00920,map01100,map01120,map01220 M00538,M00545 R02550,R03562,R05444,R05666,R06782,R06783,R09513,R11901 RC00098,RC00269,RC00490,RC01383,RC02556 br01602,ko00000,ko00001,ko00002 - - - Rieske SRD1_k127_90507_0 518766.Rmar_0304 1.898e-98 336.0 COG1600@1|root,COG1600@2|Bacteria,4NFCJ@976|Bacteroidetes,1FJQT@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes C 4Fe-4S double cluster binding domain queG - 1.17.99.6 ko:K18979 - - - - ko00000,ko01000,ko03016 - - - DUF1730,Fer4_16 SRD1_k127_90507_2 404589.Anae109_0473 2.006e-78 265.0 COG0492@1|root,COG0492@2|Bacteria,1MV15@1224|Proteobacteria,42MHR@68525|delta/epsilon subdivisions,2WIY8@28221|Deltaproteobacteria,2YUI6@29|Myxococcales 28221|Deltaproteobacteria C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family trxB - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2,Thioredoxin SRD1_k127_917666_6 760568.Desku_0313 0.0007066 46.0 COG1250@1|root,COG1250@2|Bacteria,1TPJS@1239|Firmicutes,248AE@186801|Clostridia 186801|Clostridia I 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain - - 1.1.1.157 ko:K00074 ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120 - R01976,R05576,R06941 RC00029,RC00117 ko00000,ko00001,ko01000 - - - 3HCDH,3HCDH_N SRD1_k127_917666_4 862908.BMS_2002 5.919e-68 240.0 COG3396@1|root,COG3396@2|Bacteria,1MVQ7@1224|Proteobacteria,43187@68525|delta/epsilon subdivisions,2WWG4@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Phenylacetic acid catabolic protein - - 1.14.13.149 ko:K02609 ko00360,ko01120,map00360,map01120 - R09838 RC02690 ko00000,ko00001,ko01000 - - - PaaA_PaaC SRD1_k127_917666_3 997346.HMPREF9374_3293 6.21e-79 282.0 COG1024@1|root,COG1024@2|Bacteria,1TQ2V@1239|Firmicutes,4HBT0@91061|Bacilli,27B90@186824|Thermoactinomycetaceae 91061|Bacilli I Enoyl-CoA hydratase/isomerase - - 5.3.3.18 ko:K15866 ko00360,ko01120,map00360,map01120 - R09837,R09839 RC00004,RC00326,RC02689,RC03003 ko00000,ko00001,ko01000 - - - ECH_1 SRD1_k127_917666_2 997346.HMPREF9374_3292 3.036e-96 335.0 COG1024@1|root,COG1024@2|Bacteria,1TQ89@1239|Firmicutes,4HB73@91061|Bacilli,27BNS@186824|Thermoactinomycetaceae 91061|Bacilli I Enoyl-CoA hydratase/isomerase - - - - - - - - - - - - ECH_1 SRD1_k127_917666_1 1121090.KB894700_gene3295 4.514e-105 348.0 COG1024@1|root,COG1024@2|Bacteria,1TQ89@1239|Firmicutes,4IU6J@91061|Bacilli 91061|Bacilli I Enoyl-CoA hydratase/isomerase - - - - - - - - - - - - 3HCDH,3HCDH_N,ECH_1,ECH_2 SRD1_k127_917666_5 997346.HMPREF9374_3780 5.02e-32 130.0 COG3224@1|root,COG3224@2|Bacteria,1V83H@1239|Firmicutes,4HJC6@91061|Bacilli,27C4H@186824|Thermoactinomycetaceae 91061|Bacilli S Methylmuconolactone methyl-isomerase ethD - - - - - - - - - - - EthD SRD1_k127_917666_0 671143.DAMO_1057 6.094e-128 444.0 COG1391@1|root,COG1391@2|Bacteria 2|Bacteria H [glutamate-ammonia-ligase] adenylyltransferase activity glnE GO:0000166,GO:0000287,GO:0000820,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006521,GO:0006541,GO:0006542,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0008882,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0010565,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0019222,GO:0019752,GO:0030554,GO:0031323,GO:0032553,GO:0032555,GO:0032559,GO:0033238,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0050789,GO:0050794,GO:0051171,GO:0062012,GO:0065007,GO:0070566,GO:0071704,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.7.42,2.7.7.89 ko:K00982 - - - - ko00000,ko01000 - - - GlnD_UR_UTase,GlnE SRD1_k127_943822_1 247490.KSU1_D0807 2.351e-63 228.0 2BRMQ@1|root,32KM4@2|Bacteria,2J4AR@203682|Planctomycetes 247490.KSU1_D0807|- - - - - - - - - - - - - - - - SRD1_k127_943822_0 909663.KI867150_gene2235 1.643e-67 239.0 COG2733@1|root,COG2733@2|Bacteria,1MX3G@1224|Proteobacteria,42UZD@68525|delta/epsilon subdivisions,2WQX5@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Protein of unknown function (DUF445) - - - - - - - - - - - - DUF445 SRD1_k127_949199_1 926550.CLDAP_22550 2.586e-57 202.0 COG1082@1|root,COG1082@2|Bacteria,2G9TG@200795|Chloroflexi 200795|Chloroflexi G Xylose isomerase-like TIM barrel - - 5.1.3.30,5.1.3.31 ko:K18910 - - R10817,R10818 RC03111,RC03283 ko00000,ko01000 - - - AP_endonuc_2 SRD1_k127_949199_0 1191523.MROS_1888 2.943e-170 570.0 COG1572@1|root,COG1572@2|Bacteria 2|Bacteria NU bacterial-type flagellum-dependent cell motility porU - - - - - - - - - - - Peptidase_C25 SRD1_k127_963903_2 479434.Sthe_0731 2.113e-29 118.0 COG4832@1|root,COG4832@2|Bacteria,2G9F2@200795|Chloroflexi 200795|Chloroflexi S GyrI-like small molecule binding domain - - - - - - - - - - - - GyrI-like SRD1_k127_963903_1 269799.Gmet_2818 3.587e-39 162.0 COG0784@1|root,COG2202@1|root,COG2208@1|root,COG3829@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2208@2|Bacteria,COG3829@2|Bacteria,1NC9X@1224|Proteobacteria,43C4D@68525|delta/epsilon subdivisions,2X7EU@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Domains REC, PAS, PAS, PP2C - - 3.1.3.3 ko:K07315 - - - - ko00000,ko01000,ko03021 - - - PAS_3,PAS_9,Response_reg,SpoIIE SRD1_k127_963903_0 1499967.BAYZ01000195_gene3106 1.654e-126 425.0 COG1807@1|root,COG1807@2|Bacteria,2NPZC@2323|unclassified Bacteria 2|Bacteria M Dolichyl-phosphate-mannose-protein mannosyltransferase MA20_19960 - - - - - - - - - - - PMT_2 SRD1_k127_963903_3 518766.Rmar_2301 2.563e-13 78.0 COG0457@1|root,COG0457@2|Bacteria 518766.Rmar_2301|- S peptidyl-tyrosine sulfation - - - - - - - - - - - - - SRD1_k127_987366_0 945713.IALB_1170 2.738e-111 399.0 2E09V@1|root,32VXB@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - SRD1_k127_987366_1 945713.IALB_2620 1.019e-17 86.0 COG1198@1|root,COG1198@2|Bacteria 2|Bacteria L DNA replication, synthesis of RNA primer priA GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 - ko:K04066 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,ResIII SRD1_k127_99476_0 945713.IALB_0548 3.234e-136 448.0 COG0213@1|root,COG0213@2|Bacteria 2|Bacteria F phosphorylase activity pdp GO:0003674,GO:0003824,GO:0004645,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0009032,GO:0016740,GO:0016757,GO:0016758,GO:0016763,GO:0044424,GO:0044444,GO:0044464 2.4.2.2,2.4.2.4 ko:K00756,ko:K00758 ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219 - R01570,R01876,R02296,R02484,R08222,R08230 RC00063 ko00000,ko00001,ko01000 - - iHN637.CLJU_RS08925 Glycos_trans_3N,Glycos_transf_3,PYNP_C ## 2560 queries scanned ## Total time (seconds): 263.77239656448364 ## Rate: 9.71 q/s